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- interpro_active_site/advanced/idx2term.json +1 -0
- interpro_active_site/advanced/plot_0.png +3 -0
- interpro_active_site/basic/idx2term.json +1 -0
- interpro_active_site/basic/plot_0.png +3 -0
- interpro_active_site/consensus.joblib +3 -0
- interpro_active_site/df_merge.tsv +3 -0
- interpro_active_site/metrics.json +7 -0
- interpro_active_site/paths.json +1 -0
- interpro_active_site/result.tsv +10 -0
- interpro_active_site/selections.json +1 -0
- interpro_binding_site/advanced/idx2term.json +1 -0
- interpro_binding_site/advanced/plot_0.png +3 -0
- interpro_binding_site/basic/idx2term.json +1 -0
- interpro_binding_site/basic/plot_0.png +3 -0
- interpro_binding_site/basic/plot_1.png +3 -0
- interpro_binding_site/basic/plot_2.png +3 -0
- interpro_binding_site/consensus.joblib +3 -0
- interpro_binding_site/df_merge.tsv +2 -0
- interpro_binding_site/metrics.json +7 -0
- interpro_binding_site/paths.json +1 -0
- interpro_binding_site/result.tsv +9 -0
- interpro_binding_site/selections.json +1 -0
- interpro_conserved_site/advanced/idx2term.json +1 -0
- interpro_conserved_site/basic/idx2term.json +1 -0
- interpro_conserved_site/basic/plot_0.png +3 -0
- interpro_conserved_site/basic/plot_1.png +3 -0
- interpro_conserved_site/basic/plot_2.png +3 -0
- interpro_conserved_site/basic/plot_3.png +3 -0
- interpro_conserved_site/basic/plot_4.png +3 -0
- interpro_conserved_site/basic/plot_5.png +3 -0
- interpro_conserved_site/basic/plot_6.png +3 -0
- interpro_conserved_site/basic/plot_7.png +3 -0
- interpro_conserved_site/basic/plot_8.png +3 -0
- interpro_conserved_site/consensus.joblib +3 -0
- interpro_conserved_site/df_merge.tsv +1 -0
- interpro_conserved_site/metrics.json +7 -0
- interpro_conserved_site/paths.json +1 -0
- interpro_conserved_site/result.tsv +43 -0
- interpro_conserved_site/selections.json +1 -0
- interpro_domain/advanced/idx2term.json +1 -0
- interpro_domain/advanced/plot_0.png +3 -0
- interpro_domain/advanced/plot_1.png +3 -0
- interpro_domain/advanced/plot_2.png +3 -0
- interpro_domain/advanced/plot_3.png +3 -0
- interpro_domain/advanced/plot_4.png +3 -0
- interpro_domain/advanced/plot_5.png +3 -0
- interpro_domain/advanced/plot_6.png +3 -0
- interpro_domain/advanced/plot_7.png +3 -0
- interpro_domain/advanced/plot_8.png +3 -0
- interpro_domain/advanced/plot_9.png +3 -0
interpro_active_site/advanced/idx2term.json
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{"0": "Serine/threonine-protein kinase, active site [IPR008271]"}
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interpro_active_site/advanced/plot_0.png
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interpro_active_site/basic/idx2term.json
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{"0": "Serine/threonine-protein kinase, active site [IPR008271]"}
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interpro_active_site/basic/plot_0.png
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interpro_active_site/consensus.joblib
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version https://git-lfs.github.com/spec/v1
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oid sha256:4547d9923410abf923b0672a98d08048e586c4b1b2b0fb4424f960c538de8206
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size 79596
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interpro_active_site/df_merge.tsv
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term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500
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Serine/threonine-protein kinase, active site [IPR008271] 33 59 3.575388513998969 0.0003497081781946 14.96359223300971 48.092233009708735 -0.2514056606840174 0.5845564538757478 7.386430402173519 10.05983255009733 0.9463339478376924 0.3271131887386243 0.6634464974625899 0.3764355050375718 0.6634020320082967 0.4591779800392646
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Ubiquitin-conjugating enzyme, active site [IPR023313] 4 5 2.153950234147777 0.0312440748698281 2.941747572815534 5.601941747572815 -0.2752660098412252 0.4763282738496994 1.5568529541181904 0.8795387783526502 0.970372159321031 0.2983809723869815 0.0967463289884207 0.1880666528119386 0.4147125777305785 0.088385561156941
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interpro_active_site/metrics.json
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{
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"type_of_task": "ranksum",
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"signature_size": 3352,
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"annotations_size": 54,
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"title": "Average number of proteins per term",
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"value": 2.962962962962963
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}
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interpro_active_site/paths.json
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{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C097/C097_val_log2fc"}
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interpro_active_site/result.tsv
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Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
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Serine/threonine-protein kinase, active site [IPR008271] 0.4937430841958833 3.575388513998969 0.0003497081781946 0.0187102924187359 0.018884241622513 59 P49761,Q00535,P33981,P53350,Q8TD19,P52564,Q99570,Q96KB5,O75116,Q16512,O96017,O15111,P36507,P11802,O43318,Q96SB4,P19784,P78362,O43683,Q13555,Q13464,O14965,P31751,P28482,Q16513,Q14012,Q13153,P45985,Q99986,Q9NYV4,Q9H2G2,Q00534,P17612 33
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Peptidase family C14A, His active site [IPR016129] 0.8473715651134954 2.198746487402937 0.0278959534446994 0.7829856002486778 0.1687180042970721 4 P55212,P42574,Q14790 3
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Peptidase family C14A, cysteine active site [IPR033139] 0.8473715651134954 2.198746487402937 0.0278959534446994 0.7829856002486778 0.1687180042970721 4 P55212,P42574,Q14790 3
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Ubiquitin-conjugating enzyme, active site [IPR023313] 0.7965342097400587 2.153950234147777 0.0312440748698281 0.8198741366788258 0.1687180042970721 5 P68036,P49427,P61086,Q16763 4
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Protein-tyrosine phosphatase, active site [IPR016130] 0.5757757406545003 1.4147196411491854 0.157150713263813 0.9999021646335806 0.3815795494487377 7 Q8NCE2,O60942,Q06124 3
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Ubiquitin-activating enzyme E1, Cys active site [IPR033127] 0.7503732457449978 1.206534486279664 0.2276114701971925 0.9999991227284392 0.4727315150249383 3 P22314,Q9UBT2 2
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Adenosine/AMP deaminase active site [IPR006650] 0.9373134328358216 1.0351854276152583 0.300582322890798 0.9999999958716488 0.5410481812034363 2 P00813 1
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Nucleoside diphosphate kinase, active site [IPR023005] 0.8023880597014958 0.5989861469133185 0.5491821225229754 1.0 0.6896705724707133 2 P15531 1
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L-lactate dehydrogenase, active site [IPR018177] 0.6322388059701547 0.1959549435302278 0.8446454320786476 1.0 0.9065788327772358 2 P00338 1
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interpro_active_site/selections.json
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{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase, active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, cysteine active site [IPR000169]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "AMPD2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "AURKA", "BLMH", "BUB1", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CASP3", "CASP6", "CASP7", "CASP8", "CDC34", "CDC42BPB", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK4", "CDK5", "CDK6", "CDK9", "CHEK2", "CHUK", "CKB", "CKMT1A*", "CLK3", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CTSA", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3A", "GSK3B", "GSR", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K2", "MAP2K3", "MAP2K4", "MAP2K6", "MAP3K7", "MAPK1", "MAPK3", "MARK2", "MASTL", "MDH1", "MDH2", "MTMR14", "MTMR2", "MTMR6", "NCEH1", "NEK9", "NME1", "NME2", "OXCT1", "OXSM", "PAK1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA1", "PRKAA2", "PRKACA", "PRKCB", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "RIPK1", "RNASET2", "RNGTT", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2S", "UMPS", "VRK1", "WNK1", "YES1"], "leading_proteins": ["ADA", "AKT2", "AURKA", "BUB1", "CAMK1", "CAMK2G", "CASP3", "CASP6", "CASP8", "CDC34", "CDK12", "CDK4", "CDK5", "CDK6", "CHEK2", "CHUK", "CLK3", "CSNK2A2", "LDHA", "MAP2K2", "MAP2K4", "MAP2K6", "MAP3K7", "MAPK1", "MTMR14", "NEK9", "NME1", "PAK1", "PBK", "PIK3R4", "PKN1", "PKN2", "PLK1", "PRKACA", "PTPN11", "RNGTT", "ROCK1", "ROCK2", "SLK", "SRPK1", "SRPK2", "TTK", "UBA1", "UBA2", "UBE2K", "UBE2L3", "UBE2S", "VRK1"]}
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interpro_binding_site/advanced/idx2term.json
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{"0": "Protein kinase, ATP binding site [IPR017441]"}
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interpro_binding_site/advanced/plot_0.png
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interpro_binding_site/basic/idx2term.json
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{"0": "Protein kinase, ATP binding site [IPR017441]", "1": "Beta tubulin, autoregulation binding site [IPR013838]", "2": "EF-Hand 1, calcium-binding site [IPR018247]"}
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interpro_binding_site/basic/plot_0.png
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interpro_binding_site/basic/plot_1.png
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interpro_binding_site/basic/plot_2.png
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interpro_binding_site/consensus.joblib
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version https://git-lfs.github.com/spec/v1
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oid sha256:c11bb2860d90f0dd36c79de9039fa9b1aa011a3416981a66dc0fe586c2dfd73b
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size 76717
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interpro_binding_site/df_merge.tsv
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term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500
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Protein kinase, ATP binding site [IPR017441] 32 56 3.587005924520518 0.0003344967265612 13.985436893203884 45.86407766990291 -0.192126652758297 0.6147860592683837 6.814446501353132 9.80766348241306 0.8651595242963739 0.3198537516496491 0.7148624146480367 0.4645465512342815 0.7766024211207183 0.5423224058995517
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interpro_binding_site/metrics.json
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{
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"type_of_task": "ranksum",
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"signature_size": 3352,
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"annotations_size": 31,
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"title": "Average number of proteins per term",
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"value": 5.032258064516129
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}
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interpro_binding_site/paths.json
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{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C097/C097_val_log2fc"}
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interpro_binding_site/result.tsv
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Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
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Protein kinase, ATP binding site [IPR017441] 0.5072813620200225 3.587005924520518 0.0003344967265612 0.0103175384129876 0.0103693985233994 56 P49761,Q00535,P33981,P53350,P41240,Q16539,O75116,Q16512,O15111,P36507,P11802,O43318,Q96SB4,P19784,P78362,O43683,Q13555,Q13464,Q13043,O14965,P31751,P28482,Q16513,Q14012,Q13153,P45985,Q99986,Q9NYV4,Q9UHD2,Q9H2G2,Q00534,P17612 32
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Beta tubulin, autoregulation binding site [IPR013838] 0.6511003442627634 1.785667923297136 0.0741530419824463 0.9082269166035885 0.2554160334950928 7 P68371,P04350,P07437,Q9BUF5,Q13885 5
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Peptidase M16, zinc-binding site [IPR001431] 0.5138414720916775 0.8744827537102834 0.3818554082673786 0.9999996659647572 0.6963245680169846 5 O43847 1
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EF-Hand 1, calcium-binding site [IPR018247] 0.3053593962361765 0.379500564438764 0.704316185210627 1.0 0.8806515928505666 35 Q9H4M9,P19174,P17655,Q14257,Q96D71,Q96AY3,Q15293 7
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PPM-type phosphatase, divalent cation binding [IPR000222] 0.4034725683324822 0.3401112568082449 0.7337727448671485 1.0 0.8806515928505666 4 O15355 1
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Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349] 0.7023880597014961 0.3336932901216952 0.7386110133585397 1.0 0.8806515928505666 2 P50579 1
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IQ motif, EF-hand binding site [IPR000048] 0.2306367383675482 0.1345681701356472 0.8929533092011304 1.0 0.968641690432158 11 Q15386 1
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Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578] 0.5746268656716489 0.1178977473609794 0.9061486781462122 1.0 0.968641690432158 2 Q9Y617 1
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interpro_binding_site/selections.json
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{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "ARG2", "AURKA", "BPNT1", "BUB1", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CDC42BPB", "CDK1", "CDK12", "CDK13", "CDK4", "CDK5", "CDK6", "CDK9", "CHUK", "CLK3", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "EPS15L1", "FKBP10", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "IQSEC1", "ITSN2", "LETM1", "MACF1", "MAP2K1", "MAP2K2", "MAP2K3", "MAP2K4", "MAP2K6", "MAP3K7", "MAPK1", "MAPK14", "MAPK3", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK1", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1F", "PPM1G", "PPM1L", "PRKAA1", "PRKAA2", "PRKACA", "PRKCB", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK4", "TBK1", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1", "YES1"], "leading_proteins": ["AKT2", "AURKA", "BUB1", "CAMK1", "CAMK2G", "CAPN2", "CDK12", "CDK4", "CDK5", "CDK6", "CHUK", "CLK3", "CSK", "CSNK2A2", "EHD1", "FKBP10", "MAP2K2", "MAP2K4", "MAP3K7", "MAPK1", "MAPK14", "METAP2", "NRDC", "PAK1", "PKN1", "PKN2", "PLCG1", "PLK1", "PPM1G", "PRKACA", "PSAT1", "RCN1", "RCN2", "REPS1", "ROCK1", "ROCK2", "SLK", "SRPK1", "SRPK2", "STK4", "TBK1", "TTK", "TUBB", "TUBB2A", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "VRK1"]}
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interpro_conserved_site/advanced/idx2term.json
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{}
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interpro_conserved_site/basic/idx2term.json
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{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "2": "Tubulin, conserved site [IPR017975]", "3": "Chaperonin TCP-1, conserved site [IPR002194]", "4": "Ubiquitin specific protease, conserved site [IPR018200]", "5": "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "6": "Kinesin motor domain, conserved site [IPR019821]", "7": "Zinc finger, RING-type, conserved site [IPR017907]", "8": "Actinin-type actin-binding domain, conserved site [IPR001589]"}
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interpro_conserved_site/basic/plot_0.png
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Git LFS Details
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interpro_conserved_site/basic/plot_1.png
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interpro_conserved_site/basic/plot_2.png
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Git LFS Details
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interpro_conserved_site/basic/plot_3.png
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interpro_conserved_site/basic/plot_4.png
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Git LFS Details
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interpro_conserved_site/basic/plot_5.png
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Git LFS Details
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interpro_conserved_site/basic/plot_6.png
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Git LFS Details
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interpro_conserved_site/basic/plot_7.png
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Git LFS Details
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interpro_conserved_site/basic/plot_8.png
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Git LFS Details
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interpro_conserved_site/consensus.joblib
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version https://git-lfs.github.com/spec/v1
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oid sha256:21e70278c9d5a13bb3f7a3ffacd2b6c5c7ad461cf10b8b70e79f5253309a64ee
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size 85146
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interpro_conserved_site/df_merge.tsv
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term overlap setsize score pval overlap_mean setsize_mean score_mean pval_mean overlap_std setsize_std score_std pval_std pval_50 pval_100 pval_250 pval_500
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interpro_conserved_site/metrics.json
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{
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"type_of_task": "ranksum",
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| 3 |
+
"signature_size": 3352,
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| 4 |
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"annotations_size": 279,
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| 5 |
+
"title": "Average number of proteins per term",
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| 6 |
+
"value": 2.824372759856631
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| 7 |
+
}
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interpro_conserved_site/paths.json
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{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C097/C097_val_log2fc"}
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interpro_conserved_site/result.tsv
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Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
|
| 2 |
+
Proteasome beta-type subunit, conserved site [IPR016050] 0.6465547742034614 1.8952492006595416 0.0580593947101548 0.9999999434331782 0.4190762032145759 8 P49720,P28074,P20618,P28070,P49721 5
|
| 3 |
+
DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464] 0.5764101106317628 1.8247061883945856 0.0680453789095987 0.9999999971083898 0.4190762032145759 16 Q7Z478,Q86WJ1,Q6P158,Q8IX18,P18074,O60231 6
|
| 4 |
+
Tubulin, conserved site [IPR017975] 0.6511003442627634 1.785667923297136 0.0741530419824463 0.999999999538217 0.4401850790021813 7 P68371,P04350,P07437,Q9BUF5,Q13885 5
|
| 5 |
+
Chaperonin TCP-1, conserved site [IPR002194] 0.5730108939582609 1.520044051847889 0.1284999044896051 1.0 0.5248659626258442 8 P49368,Q99832,P50991,P40227,P17987,P48643 6
|
| 6 |
+
Ubiquitin specific protease, conserved site [IPR018200] 0.5211742935029549 1.500179003068911 0.1335680406682255 1.0 0.5248659626258442 16 Q86UV5,Q9UPT9,O94966,Q96K76,Q93008,P45974,P51784,Q96RU2,P40818 9
|
| 7 |
+
Cullin, conserved site [IPR016157] 0.6064008586020968 1.4517029119599465 0.1465842292949273 1.0 0.5526621618011449 6 Q13617,Q13618,Q13619,Q93034 4
|
| 8 |
+
Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331] 0.7897236534050314 1.358815819266995 0.1742049592165053 1.0 0.5927217514805487 3 Q14155 1
|
| 9 |
+
Clathrin adaptor, mu subunit, conserved site [IPR018240] 0.7832833013467517 1.3338662554742216 0.1822476923515132 1.0 0.612615736940629 3 Q9Y2T2 1
|
| 10 |
+
Phosphofructokinase, conserved site [IPR015912] 0.7739623768288929 1.2977667876500976 0.1943674855744994 1.0 0.6233164192561534 3 P17858,P08237 2
|
| 11 |
+
IMP dehydrogenase / GMP reductase, conserved site [IPR015875] 0.756345177664961 1.2296062767997211 0.2188445784100006 1.0 0.6623432469712385 3 Q9P2T1,P20839 2
|
| 12 |
+
Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412] 0.4713572044460673 1.2050984170177577 0.2281653108470873 1.0 0.6674296489888435 14 Q9P2J5,P26640,P07814,P47897,P41252,P23381,P54136 7
|
| 13 |
+
Mrp, conserved site [IPR000808] 0.7301034508729122 1.128422032583512 0.259141727229212 1.0 0.6951975182399053 3 Q9Y5Y2 1
|
| 14 |
+
14-3-3 protein, conserved site [IPR023409] 0.4968568382531855 1.0227204740233795 0.3064400281565951 1.0 0.7682280755779253 7 P31946,P27348 2
|
| 15 |
+
HMG box A DNA-binding domain, conserved site [IPR017967] 0.6884986990031459 0.9696740553549288 0.3322089866479358 1.0 0.792301349644149 3 P09429 1
|
| 16 |
+
Kinesin motor domain, conserved site [IPR019821] 0.4210467622236042 0.9153255041483546 0.3600207739005858 1.0 0.8064140481181525 14 Q99661,Q15058,P33176,Q96Q89,P52732,O60333 6
|
| 17 |
+
Oxysterol-binding protein, conserved site [IPR018494] 0.4613954580566096 0.7660459873250592 0.4436489395376237 1.0 0.8279050390757784 6 P22059,Q96SU4,Q9BZF3 3
|
| 18 |
+
Mitogen-activated protein (MAP) kinase, conserved site [IPR003527] 0.6290758967998564 0.7499379847854124 0.4532920558272821 1.0 0.8320294972092876 3 P28482 1
|
| 19 |
+
Phosphatidylinositol 3/4-kinase, conserved site [IPR018936] 0.4337644315296222 0.7193945943615955 0.4718978265646212 1.0 0.8530889607213245 7 Q13535 1
|
| 20 |
+
Dynamin, GTPase region, conserved site [IPR019762] 0.8173134328358231 0.6438836476654733 0.5196508863232758 1.0 0.8963986382922134 2 O00429 1
|
| 21 |
+
Ubiquitin conserved site [IPR019954] 0.5878653535772396 0.6058854342460944 0.5445908323679414 1.0 0.9125730961268518 3 P46379 1
|
| 22 |
+
Ras GTPase-activating protein, conserved site [IPR023152] 0.586443714541647 0.6010827033852744 0.5477849031519446 1.0 0.9125730961268518 3 P46940,P21359 2
|
| 23 |
+
Ubiquitin-activating enzyme E1, conserved site [IPR018074] 0.8020895522388085 0.5980997164773257 0.5497733994361262 1.0 0.9125730961268518 2 Q9UBT2 1
|
| 24 |
+
Zinc finger, RING-type, conserved site [IPR017907] 0.3631587784192616 0.5881392510370853 0.5564388290399722 1.0 0.9125730961268518 19 O15344,Q14258,Q5VTR2,O95376,P19474,Q14527,Q9UPN9,P22681 8
|
| 25 |
+
Fructose-bisphosphate aldolase class-I active site [IPR029768] 0.7982089552238816 0.5866189161788037 0.5574596754556114 1.0 0.9125730961268518 2 P09972 1
|
| 26 |
+
Helix-hairpin-helix motif, class 2 [IPR008918] 0.793432835820901 0.5725998452534589 0.5669156645179687 1.0 0.9142743953786896 2 Q9UQ84 1
|
| 27 |
+
XPG conserved site [IPR019974] 0.793432835820901 0.5725998452534589 0.5669156645179687 1.0 0.9142743953786896 2 Q9UQ84 1
|
| 28 |
+
Purine phosphorylase, family 2, conserved site [IPR018099] 0.7800000000000056 0.5338587902352129 0.593439235364994 1.0 0.9407360606070077 2 Q13126 1
|
| 29 |
+
Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770] 0.7364179104477637 0.4160177804228269 0.6773969924784313 1.0 0.9807269104065692 2 P06730 1
|
| 30 |
+
Profilin conserved site [IPR027310] 0.734925373134331 0.412216966164904 0.6801804026918581 1.0 0.9807269104065692 2 P35080 1
|
| 31 |
+
Alcohol dehydrogenase, zinc-type, conserved site [IPR002328] 0.7179104477612002 0.3700948594479744 0.7113118121835174 1.0 0.9807269104065692 2 Q00796 1
|
| 32 |
+
Rel homology domain, conserved site [IPR030492] 0.703283582089556 0.3357387741112904 0.7370678637739252 1.0 0.9807269104065692 2 Q00653 1
|
| 33 |
+
Actin/actin-like conserved site [IPR020902] 0.4911534125165862 0.3155187983944882 0.7523677803812925 1.0 0.9825332543775562 3 P61163 1
|
| 34 |
+
GTP1/OBG, conserved site [IPR006074] 0.6725373134328403 0.2695233565473214 0.7875269710646449 1.0 0.9964110071300216 2 Q9Y295 1
|
| 35 |
+
tRNA-dihydrouridine synthase, conserved site [IPR018517] 0.6382089552238859 0.2058732267266906 0.8368899394344851 1.0 0.9964110071300216 2 Q6P1R4 1
|
| 36 |
+
DnaJ domain, conserved site [IPR018253] 0.2424845897724784 0.1588848981236496 0.8737595590988045 1.0 1.0 11 O60884,P31689 2
|
| 37 |
+
Alpha-D-phosphohexomutase, conserved site [IPR016066] 0.4122939343036108 0.1533303443970814 0.8781377722335437 1.0 1.0 3 O95394 1
|
| 38 |
+
Actinin-type actin-binding domain, conserved site [IPR001589] 0.2297783103654937 0.1226259088023625 0.9024033370208672 1.0 1.0 14 P46939,O15020,Q9UPN3,Q15149,Q03001,Q14651,O75369,Q14315,O43707,P21333,P12814,Q01082,P13797 13
|
| 39 |
+
Tr-type G domain, conserved site [IPR031157] 0.2671114121118708 0.112611364243914 0.9103386750012306 1.0 1.0 6 Q05639 1
|
| 40 |
+
Procollagen-lysine 5-dioxygenase, conserved site [IPR001006] 0.3159151985667253 0.0592836997672978 0.9527261439796642 1.0 1.0 3 O00469,O60568 2
|
| 41 |
+
Polyprenyl synthetase, conserved site [IPR033749] 0.4594029850746369 0.0447490433138045 0.964307341913662 1.0 1.0 2 O95749 1
|
| 42 |
+
Homeobox, conserved site [IPR017970] 0.3916417910447846 0.0335830696411578 0.9732096231221844 1.0 1.0 2 P31260 1
|
| 43 |
+
Polyamine biosynthesis domain, conserved site [IPR030373] 0.3680597014925459 0.0321362998207217 0.9743633552799372 1.0 1.0 2 P19623 1
|
interpro_conserved_site/selections.json
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{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "Arrestin, conserved site [IPR017864]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAMSAP, spectrin and Ca2+/calmodulin-binding region [IPR031372]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Carbonic anhydrase, alpha-class, conserved site [IPR018338]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific, conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "FeS cluster insertion, C-terminal, conserved site [IPR017870]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MoaA/NifB/PqqE, iron-sulphur binding, conserved site [IPR000385]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Pyridoxamine 5'-phosphate oxidase, conserved site [IPR019740]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P, conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium/solute symporter, conserved site [IPR018212]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Transcription factor, T-box, conserved site [IPR018186]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Uncharacterised protein family UPF0029, Impact, conserved site [IPR020569]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AACS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACIN1", "ACLY", "ACSF2", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP1S2", "AP2M1", "AP2S1", "AP3M1", "APEX1", "ARHGEF7", "ARIH2", "ARRB1", "ARSA", "ATAD1", "ATAD2", "ATAD2B", "ATM", "ATP5C1", "ATP5O", "ATR", "BAG6", "BAZ1A", "BAZ1B", "BAZ2A", "BCAT2", "BCS1L", "BDH2", "BLM", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BUD31", "CA8", "CAD", "CALR", "CAMSAP3", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX3", "CBX4", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CD320", "CDC40", "CDH2", "CDKAL1", "CHAF1B", "CHD1", "CHD1L", "CHD3", "CHD4", "CIAO1", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1A", "CORO1B", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX31", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG1", "DLG3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC21", "DNAJC9", "DNM1L", "DNM2", "DNMBP", "DNMT1", "DRG1", "DRG2", "DSC2", "DSC3", "DSG2", "DST", "DTYMK", "DUS1L", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EED", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EHHADH", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP1", "FARP2", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXC1", "FOXK1", "FOXK2", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GGPS1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPR2", "GNB1", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HOXA10", "HOXD11", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "ILVBL", "IMPACT", "IMPDH1", "IMPDH2", "IQGAP1", "IQGAP2", "ISCA2", "IVD", "KATNA1", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF1A", "KIF1B", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LIG4", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME1", "ME2", "MGA", "MGST2", "MID1", "MIF", "MKRN2", "MOCS1", "MPI", "MPP1", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFM", "NES", "NF1", "NFKB2", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NSUN6", "NUBP1", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL3", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PEX1", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF2", "PHF3", "PHF8", "PHGDH", "PHIP", "PHRF1", "PI4KA", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMS1", "PNP", "PNPLA6", "PNPO", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR3B", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIG", "PPIH", "PPIL1", "PPIL2", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP4", "RBBP7", "RCL1", "RDH13", "RDX", "RELA", "RIDA", "RNF169", "RNF2", "RNF20", "RNF31", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RTCA", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SFN", "SLC1A5", "SLC27A2", "SLC27A4", "SLC2A1", "SLC5A6", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STRN", "STX12", "STX18", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP1", "TAP2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLE4", "TLN1", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRAF2", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN3", "TSPAN6", "TST", "TTF2", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBFD1", "UHRF1", "USP10", "USP11", "USP14", "USP19", "USP22", "USP24", "USP28", "USP33", "USP34", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR47", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2"], "leading_proteins": ["ACTN1", "ACTN4", "ACTR1A", "ALDOC", "AP3M1", "ARHGEF7", "ARIH2", "ATR", "BAG6", "CBL", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CHD1L", "CUL2", "CUL3", "CUL4A", "CUL5", "DHX16", "DHX29", "DHX40", "DHX57", "DNAJA1", "DNAJA2", "DNM1L", "DRG1", "DST", "DUS1L", "EEF1A2", "EIF4E", "EPRS", "ERCC2", "EXO1", "FLNA", "FLNB", "FLNC", "GGPS1", "GMPR2", "HLTF", "HMGB1", "HOXA10", "IARS", "IMPDH1", "IQGAP1", "KIF11", "KIF14", "KIF1B", "KIF20B", "KIF2C", "KIF5B", "LARS", "MACF1", "MAPK1", "MID1", "MTAP", "NF1", "NFKB2", "NUBP2", "OSBP", "OSBPL6", "OSBPL9", "PFKL", "PFKM", "PFN2", "PGM3", "PLEC", "PLOD2", "PLOD3", "PLS1", "PLS3", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "QARS", "RARS", "RNF20", "SORD", "SPTBN1", "SPTBN2", "SRM", "TCP1", "TRIM21", "TRIM25", "TRIM33", "TUBB", "TUBB2A", "TUBB4A", "TUBB4B", "TUBB6", "UBA2", "USP11", "USP19", "USP22", "USP28", "USP47", "USP48", "USP5", "USP8", "USP9X", "UTRN", "VARS1", "WARS", "YWHAB", "YWHAQ"]}
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{"0": "Protein kinase domain [IPR000719]", "1": "HECT domain [IPR000569]", "2": "Glutathione S-transferase, C-terminal-like [IPR010987]", "3": "Ubiquitin-conjugating enzyme E2 [IPR000608]", "4": "Phosphoribosyltransferase domain [IPR000836]", "5": "Ubiquitin-associated domain [IPR015940]", "6": "Importin-beta, N-terminal domain [IPR001494]", "7": "SH2 domain [IPR000980]", "8": "Domain of unknown function DUF1605 [IPR011709]", "9": "Helicase-associated domain [IPR007502]"}
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