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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:7f166defb09d8533f0671a7fd9eb960a371627d439135926c626413bc41bdd8d
+size 86200

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Cysteine peptidase, cysteine active site [IPR000169]	3	5	2.3995143899469378	0.0164168345457844	1.9927184466019416	4.106796116504855	-0.4055096631049736	0.4078826502023353	1.2157723137108922	1.0442874781746152	1.1544656254210668	0.3023405414752508	0.0031158708456652	0.0526645480715484	0.0047533286028597	0.0020298329670106	9.569573614901708e-05

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3391,
+    "annotations_size": 59,
+    "title": "Average number of proteins per term",
+    "value": 2.7457627118644066
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C281/C281_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,11 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Cysteine peptidase, asparagine active site [IPR025661]	0.983475951608142	2.9059924759417184	0.0036609025190548	0.1945785364156051	0.020672404734601	2	P07858	1
+Cysteine peptidase, histidine active site [IPR025660]	0.983475951608142	2.9059924759417184	0.0036609025190548	0.1945785364156051	0.020672404734601	2	P07858	1
+Serine carboxypeptidase, serine active site [IPR018202]	0.9802243211334112	2.88985650263711	0.0038541771539086	0.2037450013833707	0.020672404734601	3	Q9HB40,Q9H3G5	2
+Cysteine peptidase, cysteine active site [IPR000169]	0.8656617656628145	2.3995143899469378	0.0164168345457844	0.6234227062436161	0.0484296619100641	5	P53634,P07858,P17655	3
+Ribonucleotide reductase small subunit, acitve site [IPR030475]	0.8017114192977288	2.1335491302584386	0.032879705869266	0.8608928981326678	0.0843435933168128	2	Q7LG56	1
+Nucleoside diphosphate kinase, active site [IPR023005]	0.7390687253029664	1.8441856109907555	0.0651560946276488	0.981223832051501	0.1423781327048622	3	O75414	1
+Tyrosine-protein kinase, active site [IPR008266]	0.5953230385847836	1.1525824474857698	0.2490818110984025	0.9999999542948838	0.3194744968436032	5	Q15375	1
+Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]	0.4405429330185889	0.4825018744006128	0.6294494671934632	1.0	0.687731825266932	2	P18669	1
+Ubiquitin-activating enzyme E1, Cys active site [IPR033127]	0.4117473435655258	0.3596396317286583	0.7191166420768127	1.0	0.7714160342278537	3	Q9UBT2,P22314	2
+Ubiquitin-conjugating enzyme, active site [IPR023313]	0.3546575392146016	0.1462878663972326	0.8836941440265229	1.0	0.8989302499580146	6	P68036,P60604	2

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "DNA topoisomerase, type IA, active site [IPR023406]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 18 (GH18) active site [IPR001579]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ACVR1B", "ADA", "ADSS", "AKT1", "AKT2", "APEH", "ARAF", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "AURKB", "BLMH", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CASP2", "CASP3", "CASP7", "CDC42BPB", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CHEK1", "CHEK2", "CHUK", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTBS", "CTSA", "CTSB", "CTSC", "DAPK3", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "EPHA7", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3A", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IGF1R", "LDHA", "LDHB", "LONP1", "LONP2", "MAP2K1", "MAP2K2", "MAPK1", "MAPK3", "MDH1", "MDH2", "MTMR2", "MTMR6", "NCEH1", "NEK9", "NME1", "NME2", "NME6", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN2", "PLK1", "PREP", "PRKAA2", "PRKACA", "PRKCD", "PRPF4B", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "RNASET2", "RNGTT", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "RRM2B", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TOP3A", "TP53RK", "TPI1", "TPP2", "TTK", "TXNRD1", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UMPS", "UNG", "VRK1", "WNK1"], "leading_proteins": ["CAPN2", "CPVL", "CTSB", "CTSC", "EPHA7", "NME6", "PGAM1", "RRM2B", "SCPEP1", "UBA1", "UBA2", "UBE2G2", "UBE2L3"]}

interpro_binding_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:df09c042b49f12b859d9a730b1cbc133574f26c35a3a908cf5a10451b9a96bd7
+size 77005

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3391,
+    "annotations_size": 31,
+    "title": "Average number of proteins per term",
+    "value": 4.741935483870968
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C281/C281_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,4 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]	0.7409265269991161	1.859989145464012	0.0628870616853012	0.8664788835267917	0.2708293603380316	2	P50579	1
+Beta tubulin, autoregulation binding site [IPR013838]	0.6535735380980442	1.4298436710501838	0.1527618919201394	0.9941363244170692	0.338258474966023	5	Q13885,P04350,P68371,Q9BUF5	4
+Peptidase M16, zinc-binding site [IPR001431]	0.5690146715451876	1.0275701868298903	0.304152054153763	0.9999868796676726	0.4621716714050567	5	P22695	1

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Legume lectin, beta chain, Mn/Ca-binding site [IPR019825]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ACVR1B", "ADSS", "AKT1", "AKT2", "APEX1", "APOBEC3C", "ARAF", "AURKB", "BPNT1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDC42BPB", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CDK9", "CETN2", "CHEK1", "CHUK", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DAPK3", "DBT", "DLAT", "DLST", "DST", "EHD1", "EHD4", "EIF2AK2", "EPHA7", "EPS15", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IQCB1", "IQGAP1", "IQGAP2", "LETM1", "LRP2", "MACF1", "MAP2K1", "MAP2K2", "MAP4K5", "MAPK1", "MAPK14", "MAPK3", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "PA2G4", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKAA2", "PRKACA", "PRKCD", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["METAP2", "TUBB2A", "TUBB4A", "TUBB4B", "TUBB6", "UQCRC2"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"}

interpro_conserved_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:333d280d80804df84bea2fee972949c874ace73f480fa054bab9408f44f275b6
+size 126000

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,3 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Syntaxin/epimorphin, conserved site [IPR006012]	4	7	2.2172642791732105	0.0266050373514232	2.592233009708738	5.847087378640777	0.9961908981999794	0.2839139128702306	1.4759357288864456	1.4239341993278547	1.138258151200134	0.2914162845337057	1.0	1.0	1.0	0.0033939033653995	0.0002457979454447
+Proteasome beta-type subunit, conserved site [IPR016050]	6	8	2.038113821304093	0.0415385512449792	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	0.0748668240169799	1.0	0.0921025797166938	6.393058955734768e-05	5.436360967141595e-05

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3391,
+    "annotations_size": 290,
+    "title": "Average number of proteins per term",
+    "value": 2.720689655172414
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C281/C281_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,42 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]	0.9949837710239008	2.9526119307308445	0.0031509781139551	0.5995740168139485	0.0542659977417915	2	P05067	1
+Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]	0.9949837710239008	2.9526119307308445	0.0031509781139551	0.5995740168139485	0.0542659977417915	2	P05067	1
+Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]	0.9949837710239008	2.9526119307308445	0.0031509781139551	0.5995740168139485	0.0542659977417915	2	P05067	1
+Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]	0.991147831218648	2.9371013021284593	0.0033129586355289	0.6180070033113748	0.0542659977417915	2	P98164	1
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.9864266745352608	2.917971256658083	0.0035231682474297	0.6406731553819924	0.0542659977417915	2	P04066	1
+C-type lectin, conserved site [IPR018378]	0.9852463853644136	2.913181824584142	0.0035776621955889	0.6463269665424509	0.0542659977417915	2	Q5KU26	1
+Sulfatase, conserved site [IPR024607]	0.9843611684862776	2.909587930744343	0.0036190556700452	0.6505622642838453	0.0542659977417915	2	P34059	1
+EGF-like calcium-binding, conserved site [IPR018097]	0.9822904368358906	2.8982953765737274	0.0037519704859774	0.6638230991719871	0.0542659977417915	3	P98164,Q07954	2
+Lysosome-associated membrane glycoprotein, conserved site [IPR018134]	0.979049867217468	2.887991751559385	0.003877100394259	0.6758485360522248	0.0542659977417915	2	P13473	1
+Tetraspanin, conserved site [IPR018503]	0.961345529654761	2.8155958390688927	0.0048686872846679	0.757163671137872	0.0542659977417915	2	O60637	1
+Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]	0.934493951018	2.7045819002676157	0.00683904083361	0.8633230179496518	0.0561948934527885	2	P01889	1
+Heavy-metal-associated, conserved site [IPR017969]	0.9215107701386782	2.6503740404427516	0.0080402701790021	0.9037785105628016	0.0561948934527885	2	P35670	1
+Integrin alpha chain, C-terminal cytoplasmic region, conserved site [IPR018184]	0.8940690469164958	2.5346466424951988	0.0112560804098573	0.96247597027158	0.0572259443430667	2	P23229	1
+Cadherin conserved site [IPR020894]	0.8937426210153407	2.528804101724171	0.0114451888686133	0.9645007902636286	0.0572259443430667	3	Q14126,Q14574	2
+Ras GTPase-activating protein, conserved site [IPR023152]	0.8598795291684758	2.383179295958476	0.0171638324082079	0.9934002476324942	0.0711073056911472	3	P21359	1
+Sterol reductase, conserved site [IPR018083]	0.8436116848627789	2.317736282944104	0.0204636578498489	0.9975113688620348	0.072371472883612	2	Q9UBM7	1
+Syntaxin/epimorphin, conserved site [IPR006012]	0.8260573096944847	2.2172642791732105	0.0266050373514232	0.999598359607136	0.0845890000957934	7	O43752,Q13277,O15400,Q13190	4
+Proteasome beta-type subunit, conserved site [IPR016050]	0.7872809077831159	2.0381138213040932	0.0415385512449792	0.9999954642582746	0.1098698139088841	8	P28070,P49721,P49720,P20618,P28074,P28072	6
+Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]	0.7716140454411362	1.9990114997876371	0.045607109624919	0.9999986790490796	0.1140177740622977	2	O60573	1
+Histidine triad, conserved site [IPR019808]	0.7671879610504525	1.9790730423751943	0.0478077830954026	0.999999323696067	0.1180876473842712	2	Q9BX68	1
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.7696176891809451	1.9769307667905005	0.0480494565218758	0.999999371692879	0.1180876473842712	4	Q8N4Q0	1
+Tubulin, conserved site [IPR017975]	0.6943209065199312	1.6151929971341814	0.1062689066034392	0.9999999999999928	0.2054532194333158	6	P23258,Q13885,Q9BUF5	3
+Ubiquitin interacting motif [IPR003903]	0.6792675723567475	1.5513962212937784	0.120806760228842	1.0	0.2255769245973565	5	O14964,Q92783,P42566,Q9Y6I3	4
+14-3-3 protein, conserved site [IPR023409]	0.6515615639859479	1.4124563950241285	0.1578156212857457	1.0	0.2660844777492225	6	P31946,P62258,Q04917	3
+Phosphorylase pyridoxal-phosphate attachment site [IPR035090]	0.6400118028917113	1.3917275581506592	0.1640049138925383	1.0	0.2714556287886196	2	P11216	1
+DNA-directed DNA polymerase, family B, conserved site [IPR017964]	0.6358807907937473	1.372293427121995	0.1699721109794996	1.0	0.2753738110841054	2	P28340	1
+Cullin, conserved site [IPR016157]	0.6039269850572064	1.1848846972188567	0.2360630386224949	1.0	0.3440114633192136	6	Q13619,Q13620	2
+Ubiquitin-activating enzyme E1, conserved site [IPR018074]	0.5101799940985541	0.784516729360972	0.4327369695294853	1.0	0.5060230692078659	2	Q9UBT2	1
+Phosphofructokinase, conserved site [IPR015912]	0.4973435655253804	0.7156396588689532	0.4742138786639414	1.0	0.5522972884037871	3	P08237,Q01813	2
+Aldo/keto reductase, conserved site [IPR018170]	0.4791974033638324	0.6460738908538882	0.5182315032712097	1.0	0.598304540967408	2	P14550	1
+IMP dehydrogenase / GMP reductase, conserved site [IPR015875]	0.4786072587784054	0.6434902875601908	0.5199060149096097	1.0	0.598304540967408	2	P12268	1
+Dynein light chain, type 1/2, conserved site [IPR019763]	0.4762466804367167	0.6331789606256825	0.5266167833734925	1.0	0.6036318860802878	2	Q96FJ2	1
+Ribosomal protein L3, conserved site [IPR019926]	0.4668043670699419	0.5923226654511534	0.5536345411397807	1.0	0.6321024288603796	2	P39023	1
+GTP1/OBG, conserved site [IPR006074]	0.4547064030687548	0.5409771307590003	0.5885233457389152	1.0	0.6666866025948649	2	P55039	1
+Heat shock protein Hsp90, conserved site [IPR019805]	0.4510035419126305	0.5145823820315548	0.6068448789784309	1.0	0.6818904247221975	3	P08238,P07900	2
+S100/Calbindin-D9k, conserved site [IPR001751]	0.4476246680436708	0.5115032837024763	0.6089986896656867	1.0	0.6818904247221975	2	P60903	1
+4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]	0.4386068476977546	0.4638062365109973	0.642786574759256	1.0	0.7142073052880623	3	P21912,O00217	2
+Guanylate kinase, conserved site [IPR020590]	0.4324830966463481	0.4084478410859581	0.6829449163140724	1.0	0.7473736820040792	6	Q8N3R9,Q14168	2
+DnaJ domain, conserved site [IPR018253]	0.4176503935851051	0.3160975512261646	0.7519284653656282	1.0	0.8076268702075265	10	Q99543,O60884,Q9UBS4	3
+Profilin conserved site [IPR027310]	0.3502508114488002	0.1701337181734154	0.8649049767887156	1.0	0.8960951888449695	2	P35080	1
+Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]	0.3023467883291554	0.0197306019516567	0.9842582787006224	1.0	0.9910934056360434	8	Q9UNP9	1

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Anion exchange, conserved site [IPR018241]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bax inhibitor 1, conserved site [IPR006213]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site [IPR020611]", "Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site [IPR014783]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family A, conserved site [IPR019760]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Ephrin, conserved site [IPR019765]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Fork head domain conserved site 2 [IPR030456]", "Fork head domain conserved site1 [IPR018122]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Heavy-metal-associated, conserved site [IPR017969]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Integrin alpha chain, C-terminal cytoplasmic region, conserved site [IPR018184]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "MnmG-related, conserved site [IPR020595]", "MoaA/NifB/PqqE, iron-sulphur binding, conserved site [IPR000385]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S14, conserved site [IPR018271]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinate dehydrogenase, cytochrome b subunit, conserved site [IPR018495]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "Tyrosine-protein kinase, receptor class V, conserved site [IPR001426]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]", "tRNA-dihydrouridine synthase, conserved site [IPR018517]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADS", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSS1", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR1B", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APLP2", "APP", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "ATP7A", "ATP7B", "BAG6", "BAX", "BAZ1A", "BAZ1B", "BCAT1", "BCAT2", "BCS1L", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD1", "BRD2", "BRD4", "BTRC", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBR4", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDK5RAP1", "CDKAL1", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CORO7", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CUX1", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DLG1", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC16", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNM3", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC3", "DSG2", "DST", "DTYMK", "DUS2", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EFNB1", "EIF3I", "EIF4A1", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPDR1", "EPHA7", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP1", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FOXK1", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GALNS", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "GUSB", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HOXD11", "HOXD13", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IGF1R", "ILVBL", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "ITGA6", "ITGAV", "IVD", "KDM5A", "KDSR", "KIF11", "KIF18A", "KIF18B", "KIF1A", "KIF1B", "KIF20A", "KIF20B", "KIF22", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIF5C", "KIF7", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRP2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MID1", "MIF", "MOCS1", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPST", "MRC2", "MRPL13", "MRPL24", "MRPL3", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTO1", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL2", "OSBPL8", "OSBPL9", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PAM", "PATZ1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PDSS1", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF14", "PHF2", "PHF3", "PHGDH", "PHIP", "PHRF1", "PI4KA", "PI4KB", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMS1", "PNP", "PNPLA6", "POLA1", "POLD1", "POLG", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKAR2B", "PRKDC", "PRPF19", "PRPF4", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAD18", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP4", "RBBP7", "RCL1", "RDH13", "RDX", "RIDA", "RING1", "RIOK2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS29", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RSF1", "RTCA", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SDHC", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLC2A1", "SLC4A2", "SLIT2", "SMARCA4", "SMG1", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX12", "STX18", "STX3", "STX4", "STX5", "STX6", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAP1", "TAP2", "TBL1XR1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMBIM6", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM27", "TRIM28", "TRIM32", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TST", "TTF2", "TUBB", "TUBB2A", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUFM", "TXN2", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP19", "USP24", "USP28", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WARS2", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["AKR1A1", "APP", "ATP7B", "COLEC12", "CUL4A", "CUL4B", "DHCR7", "DNAJA2", "DNAJB11", "DNAJC2", "DRG2", "DSC3", "DSG2", "DYNLL2", "EIF4E2", "EPN1", "EPS15", "FUCA1", "GALNS", "HGS", "HINT2", "HLA-B", "HSP90AA1", "HSP90AB1", "IMPDH2", "ITGA6", "LAMP2", "LRP1", "LRP2", "MPP2", "MPP5", "NDUFS8", "NF1", "PFKM", "PFKP", "PFN2", "POLD1", "PPIE", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PYGB", "RPL3", "S100A10", "SDHB", "STAM", "STX3", "STX5", "STX6", "STX7", "TSPAN3", "TUBB2A", "TUBB6", "TUBG1", "UBA2", "YWHAB", "YWHAE", "YWHAH", "ZADH2"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Immunoglobulin-like domain [IPR007110]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Immunoglobulin-like domain [IPR007110]", "1": "Target SNARE coiled-coil homology domain [IPR000727]", "2": "LIS1 homology motif [IPR006594]", "3": "EF-hand domain [IPR002048]", "4": "von Willebrand factor, type A [IPR002035]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:a47682a3365f9acc8295d3c1668a0357e0b89760bdaa53d65a41cf529ba5100f
+size 502797

interpro_domain/df_merge.tsv

@@ -0,0 +1,9 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+EGF-like domain [IPR000742]	3	5	2.875378173992592	0.0040354384043617	1.812807881773399	3.940886699507389	-0.2515571357977262	0.397990648527913	1.5407225921455587	2.4527963737747185	1.3250723622342764	0.3076599741691995	0.0209998346349405	0.0060673937801388	0.0060698672163979	0.1135382716428265	0.5077964068323771
+Ricin B, lectin domain [IPR000772]	3	5	2.649326682357421	0.0080652328516972	1.4174757281553398	4.121359223300971	0.4009585995426035	0.4855340701643459	1.119329478938434	0.8894364404712861	0.9609441077042546	0.3172385378622441	0.1101969479300293	1.0	0.1349531130589082	0.0003774704498572	0.0048822579474643
+Aminopeptidase N-like , N-terminal domain [IPR045357]	3	6	2.48325259861364	0.0130188732853997	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0603501083335805	0.0385773062479974	0.0743799864466655	0.014977467250991	0.0003286021100258
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	3	6	2.48325259861364	0.0130188732853997	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0603501083335805	0.0385773062479974	0.0743799864466655	0.014977467250991	0.0003286021100258
+Immunoglobulin subtype 2 [IPR003598]	4	10	2.268579068740088	0.0232939356731132	2.8106796116504853	8.04126213592233	0.1764352420775828	0.5005828106358552	2.0581551085254395	2.677802743524345	1.0491539805619012	0.3137632145774063	0.0156421300540138	0.2849410889163232	0.0275216398495969	0.0246198078338957	0.1114390039799233
+Fibronectin type III [IPR003961]	3	7	2.130791912907537	0.0331062888974305	2.2257281553398056	5.589805825242719	-0.3209057323720775	0.5133796044193292	1.3812257831232946	2.0501463270450144	0.914078257814304	0.3019356379166223	0.425452185951316	0.295480255529908	0.497470817800254	0.5185914106235352	0.4545916116320574
+Immunoglobulin-like domain [IPR007110]	8	15	2.036116462428891	0.0417386620312951	4.480582524271845	12.427184466019416	0.4075261998509777	0.4433674298264088	2.6479725987944898	3.173316973839475	1.1756568118942026	0.3233613924696422	0.0571855146636762	0.4279811411777856	0.0948939281427919	0.0017059946057754	0.0476335979538943
+Immunoglobulin V-set domain [IPR013106]	3	5	2.015755057831676	0.0438255951852522	1.8814814814814815	3.639506172839506	-0.1240957684542258	0.411362008796823	1.3951513136318474	1.5958030613003984	1.3078070990153907	0.3212718057023477	0.0283352543336475	1.0	0.0420348553288257	0.0089321887950908	0.0807266025333323

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3391,
+    "annotations_size": 2702,
+    "title": "Average number of proteins per term",
+    "value": 2.2005921539600295
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C281/C281_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,257 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Amyloidogenic glycoprotein, E2 domain [IPR024329]	0.9949837710239008	2.9526119307308445	0.0031509781139551	0.9998020279565302	0.0666092070819174	2	P05067	1
+Amyloidogenic glycoprotein, heparin-binding [IPR015849]	0.9949837710239008	2.9526119307308445	0.0031509781139551	0.9998020279565302	0.0666092070819174	2	P05067	1
+Beta-amyloid precursor protein C-terminal [IPR019543]	0.9949837710239008	2.9526119307308445	0.0031509781139551	0.9998020279565302	0.0666092070819174	2	P05067	1
+Amyloidogenic glycoprotein, extracellular [IPR008154]	0.9949837710239008	2.9526119307308445	0.0031509781139551	0.9998020279565302	0.0666092070819174	2	P05067	1
+Amyloidogenic glycoprotein, copper-binding [IPR011178]	0.9949837710239008	2.9526119307308445	0.0031509781139551	0.9998020279565302	0.0666092070819174	2	P05067	1
+Pancreatic trypsin inhibitor Kunitz domain [IPR002223]	0.9949837710239008	2.9526119307308445	0.0031509781139551	0.9998020279565302	0.0666092070819174	2	P05067	1
+Complement Clr-like EGF domain [IPR026823]	0.991147831218648	2.9371013021284593	0.0033129586355289	0.9998723827781508	0.0666092070819174	2	P98164	1
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.9864266745352608	2.917971256658083	0.0035231682474297	0.9999278244833572	0.0666092070819174	2	P04066	1
+CD209-like, C-type lectin-like domain [IPR033989]	0.9852463853644136	2.913181824584142	0.0035776621955889	0.9999377391012372	0.0666092070819174	2	Q5KU26	1
+C-type lectin-like [IPR001304]	0.9852463853644136	2.913181824584142	0.0035776621955889	0.9999377391012372	0.0666092070819174	2	Q5KU26	1
+Sulfatase, N-terminal [IPR000917]	0.9843611684862776	2.909587930744343	0.0036190556700452	0.9999443498640832	0.0666092070819174	2	P34059	1
+Peptidase C1A, papain C-terminal [IPR000668]	0.983475951608142	2.9059924759417184	0.0036609025190548	0.9999503200586374	0.0666092070819174	2	P07858	1
+Cysteine-rich flanking region, C-terminal [IPR000483]	0.9820005901445836	2.899996579669356	0.0037316673202281	0.9999589953535332	0.0666092070819174	2	Q13641	1
+Leucine-rich repeat N-terminal domain [IPR000372]	0.9820005901445836	2.899996579669356	0.0037316673202281	0.9999589953535332	0.0666092070819174	2	Q13641	1
+EGF-like calcium-binding domain [IPR001881]	0.9822904368358906	2.8982953765737274	0.0037519704859774	0.9999611922413872	0.0666092070819174	3	P98164,Q07954	2
+Beta-hexosaminidase, eukaryotic type, N-terminal [IPR029019]	0.9772794334611968	2.880780499273083	0.0039669179765118	0.9999783375171076	0.0666092070819174	2	P06865	1
+Glycoside hydrolase family 20, catalytic domain [IPR015883]	0.9772794334611968	2.880780499273083	0.0039669179765118	0.9999783375171076	0.0666092070819174	2	P06865	1
+MD-2-related lipid-recognition domain [IPR003172]	0.9763942165830602	2.877172519967533	0.0040125615525274	0.9999808604112096	0.0666092070819174	2	P17900	1
+EGF-like domain [IPR000742]	0.9778148558230344	2.875378173992592	0.0040354384043617	0.999982012161218	0.0666092070819174	5	P98164,Q08431,Q07954	3
+PA domain [IPR003137]	0.9760920897284522	2.872953040858597	0.0040665455687758	0.9999834679243774	0.0666092070819174	3	Q8TCT8,P02786	2
+Fibronectin type II domain [IPR000562]	0.9632885237538558	2.820359613326383	0.0047969857951211	0.9999977229808386	0.0666092070819174	3	P11717	1
+Glycoside hydrolase family 2, catalytic domain [IPR006103]	0.9501327825317176	2.769417336574836	0.005615665233053	0.9999997535957512	0.0666092070819174	2	O00462	1
+Immunoglobulin [IPR013151]	0.9465919150191762	2.7547814667411172	0.0058731348946525	0.9999998776028514	0.0666092070819174	2	P43121	1
+Protein Kinase B, pleckstrin homology domain [IPR039026]	0.942165830628501	2.7364505867759807	0.0062105921497752	0.9999999510930728	0.0666092070819174	2	P31749	1
+Galactosyltransferase, C-terminal [IPR027791]	0.938920035408676	2.7229824322331795	0.0064695498035527	0.9999999758145556	0.0666092070819174	2	O60512	1
+Galactosyltransferase, N-terminal [IPR027995]	0.938920035408676	2.7229824322331795	0.0064695498035527	0.9999999758145556	0.0666092070819174	2	O60512	1
+MHC class I-like antigen recognition-like [IPR011161]	0.9347697756788644	2.7020121015996605	0.0068921253812443	0.9999999923380058	0.0668452728696975	3	P10321,P01889	2
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.9347697756788644	2.7020121015996605	0.0068921253812443	0.9999999923380058	0.0668452728696975	3	P10321,P01889	2
+Immunoglobulin C1-set [IPR003597]	0.9347697756788644	2.7020121015996605	0.0068921253812443	0.9999999923380058	0.0668452728696975	3	P10321,P01889	2
+MHC class I, alpha chain, C-terminal [IPR010579]	0.9347697756788644	2.7020121015996605	0.0068921253812443	0.9999999923380058	0.0668452728696975	3	P10321,P01889	2
+N-acetylgalactosaminyltransferase [IPR045885]	0.9285714285714268	2.6760687406309196	0.0074491364986466	0.99999999831737	0.0668452728696975	3	Q86SF2,Q10472	2
+Heavy metal-associated domain, HMA [IPR006121]	0.9215107701386782	2.6503740404427516	0.0080402701790021	0.9999999996635656	0.0668452728696975	2	P35670	1
+Heavy metal-associated domain, copper ion-binding [IPR006122]	0.9215107701386782	2.6503740404427516	0.0080402701790021	0.9999999996635656	0.0668452728696975	2	P35670	1
+Ricin B, lectin domain [IPR000772]	0.9237635318709896	2.6493266823574215	0.0080652328516972	0.9999999996856817	0.0668452728696975	5	Q86SF2,Q10472,Q9UBG0	3
+Glycoside hydrolase family 38, central domain [IPR015341]	0.9203304809678312	2.6454287673210186	0.0081587462875902	0.999999999756366	0.0668452728696975	2	O00754	1
+Glycoside hydrolase family 38, N-terminal domain [IPR000602]	0.9203304809678312	2.6454287673210186	0.0081587462875902	0.999999999756366	0.0668452728696975	2	O00754	1
+Glycosyl hydrolase family 38, C-terminal [IPR011682]	0.9203304809678312	2.6454287673210186	0.0081587462875902	0.999999999756366	0.0668452728696975	2	O00754	1
+Peptidase C2, calpain, domain III [IPR022683]	0.9161994688698668	2.628097555756389	0.0085863887379842	0.9999999999240238	0.0668452728696975	2	P17655	1
+Calpain subdomain III [IPR033883]	0.9161994688698668	2.628097555756389	0.0085863887379842	0.9999999999240238	0.0668452728696975	2	P17655	1
+Peptidase C2, calpain, catalytic domain [IPR001300]	0.9161994688698668	2.628097555756389	0.0085863887379842	0.9999999999240238	0.0668452728696975	2	P17655	1
+Peptidase C2, calpain, large subunit, domain III [IPR022682]	0.9161994688698668	2.628097555756389	0.0085863887379842	0.9999999999240238	0.0668452728696975	2	P17655	1
+Glycosyl transferase 64 domain [IPR015338]	0.9126586013573256	2.613214019669035	0.0089695114549768	0.9999999999732628	0.0668452728696975	2	Q93063	1
+Exostosin, GT47 domain [IPR040911]	0.9126586013573256	2.613214019669035	0.0089695114549768	0.9999999999732628	0.0668452728696975	2	Q93063	1
+ERAP1-like C-terminal domain [IPR024571]	0.9096545615589108	2.5926826621178605	0.0095230595725133	0.9999999999940914	0.0668452728696975	4	Q9UIQ6,Q6P179,Q9NZ08	3
+EXPERA domain [IPR033118]	0.8973148421363148	2.5484167917419267	0.0108213098361538	0.9999999999998292	0.0697832438598749	2	Q5BJF2	1
+Domain of unknown function DUF5600 [IPR040990]	0.894364119209208	2.535899385868316	0.0112158953412879	0.999999999999942	0.0704542855183163	2	Q9H223	1
+EH domain-containing protein, N-terminal [IPR031692]	0.894364119209208	2.535899385868316	0.0112158953412879	0.999999999999942	0.0704542855183163	2	Q9H223	1
+Integrin alpha-2 [IPR013649]	0.8940690469164958	2.5346466424951988	0.0112560804098573	0.999999999999948	0.0704542855183163	2	P23229	1
+Cadherin prodomain [IPR014868]	0.8934789023310592	2.532140608558323	0.0113368519850785	0.9999999999999584	0.0705810462296823	2	Q14574	1
+Cadherin, cytoplasmic domain [IPR000233]	0.8934789023310592	2.532140608558323	0.0113368519850785	0.9999999999999584	0.0705810462296823	2	Q14574	1
+Cadherin-like [IPR002126]	0.8937426210153407	2.528804101724171	0.0114451888686133	0.9999999999999688	0.0709286704655808	3	Q14126,Q14574	2
+HDGF-related, PWWP domain [IPR035496]	0.8910170919940108	2.5171726994714367	0.0118300826747201	0.9999999999999892	0.0719659018114675	3	Q7Z4V5	1
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8857290110049938	2.48325259861364	0.0130188732853997	0.9999999999999996	0.0731802814506346	6	Q9UIQ6,Q6P179,Q9NZ08	3
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8857290110049938	2.48325259861364	0.0130188732853997	0.9999999999999996	0.0731802814506346	6	Q9UIQ6,Q6P179,Q9NZ08	3
+Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]	0.8772499262319238	2.462938325151771	0.0137803617904346	1.0	0.0740882915558188	2	O15460	1
+Glycosyl hydrolase, family 13, catalytic domain [IPR006047]	0.8474476246680297	2.3344147666499637	0.0195740143142382	1.0	0.0845877054119034	2	P08195	1
+Immunoglobulin subtype 2 [IPR003598]	0.8390258243174702	2.268579068740088	0.0232939356731132	1.0	0.0918487013110857	10	P43121,Q9BY67,Q9Y624,Q92859	4
+NECAP, PHear domain [IPR012466]	0.8303334316907529	2.2597642646419995	0.0238358853822768	1.0	0.0933363011028908	2	Q9NVZ3	1
+Syntaxin, N-terminal domain [IPR006011]	0.8196902885194698	2.2018236140940024	0.0276777703577708	1.0	0.1010612641982389	4	O15400,Q13277	2
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.8166395100256003	2.1937131521989595	0.0282560377114833	1.0	0.1020692699150106	3	Q9Y282	1
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.8166395100256003	2.1937131521989595	0.0282560377114833	1.0	0.1020692699150106	3	Q9Y282	1
+CYRIA/CYRIB, Rac1 binding domain [IPR009828]	0.8114488049572166	2.1766794194523604	0.0295044948983009	1.0	0.1046209254792772	2	Q7L576	1
+Peptidase M20, dimerisation domain [IPR011650]	0.8067276482738276	2.155792249979711	0.0310998909163167	1.0	0.1071835526223058	2	Q8IYS1	1
+GINS subunit, domain A [IPR021151]	0.805904530926056	2.1460681241157205	0.0318675439712294	1.0	0.1076226376129801	3	Q9BRX5	1
+JmjC domain [IPR003347]	0.8026854563225105	2.1317343293913695	0.0330286929783425	1.0	0.1104338617586319	3	Q7LBC6	1
+Fibronectin type III [IPR003961]	0.806859033388942	2.130791912907537	0.0331062888974305	1.0	0.1104338617586319	7	Q15375,Q92859,P08069	3
+Cold-shock (CSD) domain [IPR019844]	0.7971773690037369	2.1013468251297676	0.0356105321241784	1.0	0.1140487557072499	4	P67809	1
+Immunoglobulin I-set [IPR013098]	0.7922347255800573	2.079147117356766	0.037603830521613	1.0	0.1160947507651065	4	Q92859	1
+Immunoglobulin-like domain [IPR007110]	0.7896658231008764	2.036116462428891	0.0417386620312951	1.0	0.1235244959568012	15	Q08722,Q9BY67,P10321,Q92859,P43121,P01889,P78310,Q9Y624	8
+Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]	0.7786957804662071	2.030832037144408	0.0422720359320329	1.0	0.1245572967157613	2	O15027	1
+Immunoglobulin V-set domain [IPR013106]	0.7794660131737572	2.015755057831676	0.0438255951852522	1.0	0.126245481290326	5	P43121,Q9BY67,Q9Y624	3
+Ras GTPase-activating domain [IPR001936]	0.7774428257163695	2.0124124427692855	0.0441764779366744	1.0	0.1263564929769534	4	P21359	1
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.7759740259740138	2.011975894918629	0.0442224780554134	1.0	0.1263564929769534	3	Q9BYT8,P52888	2
+Zinc finger, C3HC4 RING-type [IPR018957]	0.7772905418911539	2.0117231056591787	0.0442491335585129	1.0	0.1263564929769534	4	Q5VTR2	1
+Plasma membrane calcium transporting P-type ATPase, C-terminal [IPR022141]	0.7710239008557143	1.9963552793482344	0.0458952649240824	1.0	0.1290069177051319	2	P23634	1
+GYF domain [IPR003169]	0.7683682502213041	1.9843937503575368	0.0472119621909474	1.0	0.1305020169508629	2	O95400	1
+BRO1 domain [IPR004328]	0.7651097313848506	1.9628557840233103	0.0496629337433749	1.0	0.133654628460756	3	Q5VW32	1
+Tyrosine-protein kinase, catalytic domain [IPR020635]	0.7539490946372019	1.9121547964850865	0.0558563421491893	1.0	0.1435621618605934	3	Q15375	1
+CBS domain [IPR000644]	0.7558606323365643	1.893060188889507	0.0583498656785361	1.0	0.1460226879497551	8	P51798,P51797,P51790	3
+ROCK, Rho binding domain [IPR015008]	0.7459427559752159	1.8828370672236316	0.0597224520026844	1.0	0.1485912203602701	2	Q13464	1
+NIPSNAP [IPR012577]	0.7456476836825057	1.8814943763729648	0.0599046995500214	1.0	0.1489075420277441	2	Q9BPW8	1
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.7450778016670386	1.864882023138977	0.0621979427694938	1.0	0.1517706974782358	4	P13674,O15460	2
+Zinc finger, GRF-type [IPR010666]	0.7412215992918061	1.861334440203405	0.0626969624770676	1.0	0.1517706974782358	2	Q13472	1
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.7470509888544541	1.8565522852424756	0.0633748777587972	1.0	0.1527784702484018	7	Q9BV79,Q8N4Q0	2
+Coatomer, gamma subunit, appendage, Ig-like subdomain [IPR013040]	0.7400413101209835	1.8559522920521156	0.0634603584665562	1.0	0.1527784702484018	2	Q9UBF2	1
+Coatomer subunit gamma, C-terminal [IPR032154]	0.7400413101209835	1.8559522920521156	0.0634603584665562	1.0	0.1527784702484018	2	Q9UBF2	1
+Nucleoside diphosphate kinase-like domain [IPR034907]	0.7390687253029664	1.8441856109907555	0.0651560946276488	1.0	0.1554825830401409	3	O75414	1
+CD80-like, immunoglobulin C2-set [IPR013162]	0.738483304883891	1.8415031281970449	0.0655478625935011	1.0	0.156181944204268	3	Q9BY67	1
+MRH domain [IPR044865]	0.7378610192113669	1.831712696813559	0.0669942360113431	1.0	0.1580946949368114	4	P11717	1
+Chaperone DnaJ, C-terminal [IPR002939]	0.7363958583851304	1.8183301380417844	0.069013689101316	1.0	0.1614502060188362	5	O60884	1
+Immunoglobulin subtype [IPR003599]	0.7415922572245947	1.8152796176630135	0.0694809496529025	1.0	0.1622623387745398	11	P43121,Q9BY67,Q9Y624,Q92859	4
+Pre-PUA domain [IPR041366]	0.7300088521687809	1.8101008042362348	0.0702801562981552	1.0	0.1632820140306237	2	P41214	1
+Fatty acid desaturase domain [IPR005804]	0.7270581292416657	1.7965804378726018	0.072402252279101	1.0	0.1660703613396697	2	O15121	1
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.7257358893302078	1.752202916117579	0.0797389224085507	1.0	0.1753088432448365	8	Q9H223,Q9UQ16,Q9H4M9	3
+Dynamin, N-terminal [IPR045063]	0.7257358893302078	1.752202916117579	0.0797389224085507	1.0	0.1753088432448365	8	Q9H223,Q9UQ16,Q9H4M9	3
+RUN domain [IPR004012]	0.7123045146060774	1.728750154407007	0.0838538207321997	1.0	0.1793927344563765	2	Q7L099	1
+Target SNARE coiled-coil homology domain [IPR000727]	0.7223707268544387	1.723891599757476	0.0847274140754998	1.0	0.1801484179447018	11	Q13277,O15400,Q13190,Q5SQN1,O43752	5
+Glycosyltransferase 2-like [IPR001173]	0.7138233575387611	1.713490031341952	0.0866224257510164	1.0	0.1820618224995388	5	Q86SF2,Q10472	2
+CTP synthase GATase domain [IPR033828]	0.699026261434052	1.667391428386488	0.0954365971676423	1.0	0.1940177557303783	2	P17812	1
+CTP synthase, N-terminal [IPR017456]	0.699026261434052	1.667391428386488	0.0954365971676423	1.0	0.1940177557303783	2	P17812	1
+PWI domain [IPR002483]	0.701493035701237	1.655858399258815	0.0977504979404693	1.0	0.1965245066436869	5	O43395	1
+Dynamin, GTPase domain [IPR001401]	0.6966083757128174	1.640355415165983	0.1009312897827439	1.0	0.2018625795654878	4	Q9UQ16	1
+Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]	0.6943209065199312	1.6151929971341814	0.1062689066034392	1.0	0.2094099585803859	6	P23258,Q13885,Q9BUF5	3
+Tubulin/FtsZ, GTPase domain [IPR003008]	0.6943209065199312	1.6151929971341814	0.1062689066034392	1.0	0.2094099585803859	6	P23258,Q13885,Q9BUF5	3
+DNA mismatch repair protein MutS, clamp [IPR007861]	0.6792564178223673	1.5755333975520978	0.1151333758073565	1.0	0.219982027425684	2	P52701	1
+DNA mismatch repair protein MutS, core [IPR007696]	0.6794569067296322	1.5680381170984052	0.1168722369890513	1.0	0.2206769981442465	3	P52701,P20585	2
+DNA mismatch repair protein MutS-like, N-terminal [IPR007695]	0.6794569067296322	1.5680381170984052	0.1168722369890513	1.0	0.2206769981442465	3	P52701,P20585	2
+DNA mismatch repair protein MutS, C-terminal [IPR000432]	0.6794569067296322	1.5680381170984052	0.1168722369890513	1.0	0.2206769981442465	3	P52701,P20585	2
+DNA mismatch repair protein MutS, connector domain [IPR007860]	0.6794569067296322	1.5680381170984052	0.1168722369890513	1.0	0.2206769981442465	3	P52701,P20585	2
+EF-hand, Ca insensitive [IPR014837]	0.676713385964681	1.555198212167495	0.1198988699807568	1.0	0.2241984406145363	3	P12814	1
+PTB/PI domain [IPR006020]	0.6771395190610066	1.5491169936870637	0.1213535984882936	1.0	0.2258246715670588	4	O60343,Q9Y3P9	2
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.6820134862686268	1.5346190563626263	0.1248774289329683	1.0	0.2303200088579389	10	P35670,Q04656,Q9NQ11,Q8NB49	4
+EF-hand domain, type 2 [IPR015154]	0.6686338152847257	1.5259533188103394	0.1270214905366007	1.0	0.23127497805249	2	Q9Y4J8	1
+EF-hand domain, type 1 [IPR015153]	0.6686338152847257	1.5259533188103394	0.1270214905366007	1.0	0.23127497805249	2	Q9Y4J8	1
+Zinc finger, ZZ-type [IPR000433]	0.6686338152847257	1.5259533188103394	0.1270214905366007	1.0	0.23127497805249	2	Q9Y4J8	1
+Exosome complex component, N-terminal domain [IPR025721]	0.6665683092357653	1.5162962901199992	0.1294444493149624	1.0	0.2344228566012256	2	Q9Y3B2	1
+Beta-adaptin appendage, C-terminal subdomain [IPR015151]	0.6664168072811129	1.5069240532196138	0.1318301252437246	1.0	0.2379458907204702	3	Q10567	1
+Nucleotidyl transferase domain [IPR005835]	0.6653743949970214	1.502029694162643	0.1330894402228786	1.0	0.2391008427408364	3	Q9NR50	1
+HR1 rho-binding domain [IPR011072]	0.6634189548272935	1.4845186080155433	0.137671390305794	1.0	0.2435413826448496	4	Q5T0N5,O75116,Q13464	3
+LEM-like domain [IPR013146]	0.6568309235762793	1.470703906518813	0.1413712092858539	1.0	0.2452785045686787	2	P42166	1
+Tim44-like domain [IPR007379]	0.6550604898200079	1.4624032782572247	0.1436307316270331	1.0	0.2479809820167689	2	Q9BRJ2	1
+ERM family, FERM domain C-lobe [IPR041789]	0.6519069355790504	1.438690337008073	0.1502382783386799	1.0	0.2548297728004478	3	P15311	1
+14-3-3 domain [IPR023410]	0.6515615639859479	1.4124563950241285	0.1578156212857457	1.0	0.2622920992905737	6	P31946,P62258,Q04917	3
+PUA domain [IPR002478]	0.6451073230003905	1.397989388211245	0.1621162538668157	1.0	0.2670964133830097	4	P41214,Q9Y221	2
+Beta-Casp domain [IPR022712]	0.6384487596265436	1.3752238124713052	0.1690620680224328	1.0	0.2732187031527128	3	Q5TA45	1
+Cold shock domain [IPR011129]	0.6312021672717889	1.3235088918774558	0.1856662012441563	1.0	0.2884435462484148	5	P67809	1
+Cold-shock protein, DNA-binding [IPR002059]	0.6312021672717889	1.3235088918774558	0.1856662012441563	1.0	0.2884435462484148	5	P67809	1
+PWWP domain [IPR000313]	0.6361446550057254	1.3187585649958211	0.1872498406455762	1.0	0.2904414864663301	9	P51858,Q7Z4V5	2
+BTB/POZ domain [IPR000210]	0.6301574887649583	1.303092110858716	0.1925433166600698	1.0	0.2961024710389919	7	Q08380	1
+Cullin protein, neddylation domain [IPR019559]	0.6039269850572064	1.1848846972188567	0.2360630386224949	1.0	0.3362373908054724	6	Q13619,Q13620	2
+Far upstream element-binding protein, C-terminal [IPR015096]	0.5848332841546233	1.131663732560081	0.257775834557628	1.0	0.3582871939170323	2	Q92945	1
+Ras-associating (RA) domain [IPR000159]	0.5828166519043548	1.1024578365851423	0.2702626792033915	1.0	0.3686336406248111	4	Q15036,Q9Y4G8,P55196	3
+Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]	0.5793058066221064	1.0858274786910496	0.2775553267517976	1.0	0.3772406905851897	4	P10586	1
+CARP motif [IPR006599]	0.5718501032753109	1.070569650509598	0.2843629758408099	1.0	0.3824533403294517	2	O75695	1
+C-CAP/cofactor C-like domain [IPR017901]	0.5718501032753109	1.070569650509598	0.2843629758408099	1.0	0.3824533403294517	2	O75695	1
+Fzo/mitofusin HR2 domain [IPR006884]	0.5694895249336112	1.0594788803846895	0.2893817425831804	1.0	0.3857981273222296	2	O95140	1
+VHS domain [IPR002014]	0.5701572616412385	1.042551332834916	0.297156139178429	1.0	0.3932007287267948	4	O60784	1
+ATPase, dynein-related, AAA domain [IPR011704]	0.5656535851283628	1.0414705292250956	0.2976572239983177	1.0	0.3932545685625564	2	A3KMH1	1
+Band 7 domain [IPR001107]	0.5752037330624021	1.0396036379947893	0.2985240860298641	1.0	0.3932774648721077	7	P27105	1
+SGNH hydrolase-type esterase domain [IPR013830]	0.5654976992369898	1.0304694687952436	0.3027896772833354	1.0	0.3963845484590951	3	P68402	1
+DNA-directed DNA polymerase, family B, multifunctional domain [IPR006134]	0.5628689492325756	1.0181062245965071	0.3086274775383559	1.0	0.4013048336422704	3	P28340,P09884	2
+DNA-directed DNA polymerase, family B, exonuclease domain [IPR006133]	0.5628689492325756	1.0181062245965071	0.3086274775383559	1.0	0.4013048336422704	3	P28340,P09884	2
+CLASP N-terminal domain [IPR024395]	0.5503098259073514	0.9696551869483842	0.3322183947648724	1.0	0.4218299354580288	2	Q7Z460	1
+Peptidase M16, middle/third domain [IPR032632]	0.5461788138093886	0.9503933903181728	0.3419124012226384	1.0	0.429696422373753	2	P14735	1
+Sterile alpha motif domain [IPR001660]	0.5599913760987443	0.9439817062944506	0.3451789966865544	1.0	0.4323939031279879	10	Q15375,Q6UWE0	2
+Cullin homology domain [IPR016158]	0.5527816902692853	0.9329121307021886	0.3508653385558637	1.0	0.4364816504502504	7	Q13619,Q13620	2
+MOSC, N-terminal beta barrel [IPR005303]	0.5402773679551535	0.922941916097768	0.3560374753017252	1.0	0.4402806673982891	2	Q969Z3	1
+Molybdenum cofactor sulfurase, C-terminal [IPR005302]	0.5402773679551535	0.922941916097768	0.3560374753017252	1.0	0.4402806673982891	2	Q969Z3	1
+Serine-threonine/tyrosine-protein kinase, catalytic domain [IPR001245]	0.5472897127395182	0.9069374150490408	0.3644398940555986	1.0	0.4441860281638632	7	Q15375,P08069	2
+NudC N-terminal domain [IPR025934]	0.5326054883446555	0.8873853220040536	0.3748714832060114	1.0	0.4517056863714478	2	Q8IVD9	1
+Protein kinase C-like, phorbol ester/diacylglycerol-binding domain [IPR002219]	0.541876092311204	0.8814104205908524	0.3780957195309664	1.0	0.4517056863714478	7	O75116,Q05655,Q13464,P10398	4
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.5302449100029551	0.8764777548643657	0.3807703644187779	1.0	0.4517056863714478	2	O43390	1
+Uncharacterised domain CHP00451 [IPR004521]	0.5299498377102503	0.8751154713932285	0.3815110797397074	1.0	0.4517056863714478	2	Q9ULC4	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.5392778824677502	0.8608246356916243	0.3893346344165258	1.0	0.4547210560934764	8	Q9BV79,Q8N4Q0	2
+WHEP-TRS domain [IPR000738]	0.5234720992028282	0.824146320238153	0.4098564236096751	1.0	0.4690383063253142	4	P23381,P56192,P07814	3
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.5314146682305521	0.8238620565176505	0.4100179420948897	1.0	0.4690383063253142	8	Q8N3R9,Q9UDY2,Q14168	3
+Guanylate kinase-like domain [IPR008144]	0.5314146682305521	0.8238620565176505	0.4100179420948897	1.0	0.4690383063253142	8	Q8N3R9,Q9UDY2,Q14168	3
+Major facilitator superfamily domain [IPR020846]	0.5258981433668162	0.815465478639469	0.4148059170878282	1.0	0.4723158819938103	6	Q7L0J3,Q14728	2
+Diaphanous autoregulatory (DAD) domain [IPR014767]	0.5168240850058948	0.8040202832415461	0.4213852609770452	1.0	0.4769932866191773	3	O60879,O60610	2
+Bicarbonate transporter, C-terminal [IPR011531]	0.5113602832694024	0.7898841322132609	0.4295954390875227	1.0	0.4842581879075872	2	Q9Y6M7	1
+Band 3 cytoplasmic domain [IPR013769]	0.5113602832694024	0.7898841322132609	0.4295954390875227	1.0	0.4842581879075872	2	Q9Y6M7	1
+Ubiquitin-activating enzyme E1, FCCH domain [IPR032418]	0.5101799940985653	0.7845167293610228	0.4327369695294556	1.0	0.4863790730734563	2	A0AVT1	1
+Ubiquitin-activating enzyme E1, C-terminal [IPR018965]	0.5101799940985653	0.7845167293610228	0.4327369695294556	1.0	0.4863790730734563	2	A0AVT1	1
+Ubiquitin-activating enzyme E1, four-helix bundle [IPR032420]	0.5101799940985653	0.7845167293610228	0.4327369695294556	1.0	0.4863790730734563	2	A0AVT1	1
+Ubiquitin-activating enzyme, SCCH domain [IPR019572]	0.5101799940985653	0.7845167293610228	0.4327369695294556	1.0	0.4863790730734563	2	A0AVT1	1
+ZU5 domain [IPR000906]	0.5098849218058532	0.7831757936486184	0.4335238875529608	1.0	0.4868584971604738	2	Q12955	1
+L27 domain, C-terminal [IPR014775]	0.5095866390440169	0.7604686331106931	0.4469745117535582	1.0	0.4981389253264222	4	Q14168	1
+Zinc finger, UBP-type [IPR001607]	0.5064935064935012	0.7569344406228468	0.449089140482682	1.0	0.4997688869786684	3	Q7Z569,P45974	2
+NLE [IPR012972]	0.5019179699026284	0.7471158120716286	0.4549936563579577	1.0	0.50467687170739	2	Q9NVX2	1
+HECT domain [IPR000569]	0.5115539194733625	0.7402748487371484	0.4591332389672713	1.0	0.5088507020875993	7	P46934,Q15386,O95071	3
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.5113952935892705	0.739546563043915	0.4595751763119826	1.0	0.5089230026208922	7	P13674,O15460	2
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.5113952935892705	0.739546563043915	0.4595751763119826	1.0	0.5089230026208922	7	P13674,O15460	2
+Methyltransferase type 11 [IPR013216]	0.499528016118387	0.7254602868138141	0.4681696997289788	1.0	0.5178037366629966	3	O43709	1
+Diacylglycerol/phorbol-ester binding [IPR020454]	0.4988165571983258	0.7222590643990768	0.4701352156588247	1.0	0.5193575714576321	3	P10398	1
+Metastasis-associated protein MTA1, R1 domain [IPR035170]	0.4963115963411121	0.7219203630996343	0.4703434409166638	1.0	0.5193575714576321	2	Q13330	1
+Phosphofructokinase domain [IPR000023]	0.4973435655253804	0.7156396588689532	0.4742138786639414	1.0	0.5230398322487553	3	P08237,Q01813	2
+Histone deacetylase domain [IPR023801]	0.4918855119504265	0.702143832649703	0.4825894692008967	1.0	0.5313597171070998	2	Q13547	1
+Putative WW-binding domain and destruction box [IPR033461]	0.4912953673650106	0.6995149910383724	0.484230247768912	1.0	0.5329491362409776	2	Q9ULX3	1
+Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]	0.4892298613160342	0.6903294138807042	0.4899870545887217	1.0	0.5384078981288029	2	P49588	1
+Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]	0.4892298613160342	0.6903294138807042	0.4899870545887217	1.0	0.5384078981288029	2	P49588	1
+S100/CaBP-9k-type, calcium binding, subdomain [IPR013787]	0.488332665852887	0.6754043376302628	0.499418910410172	1.0	0.5476582369838818	3	Q99584	1
+Domain of unknown function DUF4749 [IPR031847]	0.4824431985836587	0.6603239066923513	0.5090459916959502	1.0	0.5577624775192447	2	Q96HC4	1
+Kinesin-like [IPR022164]	0.4828660146887082	0.6512274540861813	0.5148996705341495	1.0	0.5632627165114461	3	O60333	1
+Signal recognition particle SRP54, helical bundle [IPR013822]	0.4794924756565359	0.6473665464303371	0.5173947417960045	1.0	0.5653055367298035	2	P61011	1
+Signal recognition particle, SRP54 subunit, GTPase domain [IPR000897]	0.4794924756565359	0.6473665464303371	0.5173947417960045	1.0	0.5653055367298035	2	P61011	1
+IMP dehydrogenase/GMP reductase [IPR001093]	0.4786072587784054	0.6434902875601908	0.5199060149096097	1.0	0.5675903241558649	2	P12268	1
+PurM-like, N-terminal domain [IPR016188]	0.4780171141929917	0.6409089756785704	0.5215818239397665	1.0	0.5691898579504238	2	P49903	1
+CTLH/CRA C-terminal to LisH motif domain [IPR024964]	0.4811636166412137	0.6330795047346219	0.5266817255040626	1.0	0.5738282348032165	4	Q96S59,Q9NWU2	2
+CRA domain [IPR013144]	0.4811636166412137	0.6330795047346219	0.5266817255040626	1.0	0.5738282348032165	4	Q96S59,Q9NWU2	2
+SET domain [IPR001214]	0.4793060599377886	0.6044087421829544	0.5455719249823958	1.0	0.593213417023112	6	O96028,Q9H9B1	2
+THIF-type NAD/FAD binding fold [IPR000594]	0.4787823710278919	0.5838760288313214	0.5593037218440409	1.0	0.6069231551897986	8	Q13564	1
+Domain of unknown function DUF3517 [IPR021905]	0.4603127766302779	0.5646227230944748	0.5723304061809418	1.0	0.6195660086141445	2	Q9UPU5	1
+Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]	0.4624909758837553	0.5629172963329335	0.5734912017810676	1.0	0.6203255513260387	3	Q14241	1
+Stromalin conservative domain [IPR020839]	0.4591324874594386	0.5596227391599229	0.5757367913174833	1.0	0.622256324055936	2	Q8WVM7	1
+STAG [IPR013721]	0.4591324874594386	0.5596227391599229	0.5757367913174833	1.0	0.622256324055936	2	Q8WVM7	1
+Sec24-like, trunk domain [IPR041742]	0.4613101530708106	0.557896425306048	0.5769151126682803	1.0	0.6232805415552553	3	O95486	1
+Cullin, N-terminal [IPR001373]	0.4727101803608886	0.5573233074656554	0.5773065539835618	1.0	0.6234541602172597	8	Q13619,Q13620	2
+GTP binding protein, second domain [IPR031662]	0.4547064030687548	0.5409771307590003	0.5885233457389152	1.0	0.6342877389479337	2	P55039	1
+TOG domain [IPR034085]	0.4644265152369915	0.5399398982642748	0.5892384814247713	1.0	0.6342877389479337	6	O00410	1
+ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]	0.4496901740926691	0.5200525842847628	0.6030269251359694	1.0	0.6465788697291228	2	Q15477	1
+rRNA-processing arch domain [IPR025696]	0.4496901740926691	0.5200525842847628	0.6030269251359694	1.0	0.6465788697291228	2	Q15477	1
+Heat shock protein Hsp90, N-terminal [IPR020575]	0.4511366991437895	0.5044929690522713	0.6139150017144583	1.0	0.6579463623153124	4	P08238,Q12931,P07900	3
+Thioredoxin-like fold [IPR012336]	0.4458542342874028	0.5042072608517378	0.6141157386229525	1.0	0.6579463623153124	2	Q8NBF2	1
+CTLH, C-terminal LisH motif [IPR006595]	0.4531224641789297	0.5023540337820555	0.615418506734116	1.0	0.6590807789122399	5	Q96S59,Q9NWU2	2
+Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain [IPR020059]	0.437297137798774	0.4693772097826031	0.6388000355400001	1.0	0.6827680759608704	2	P07814	1
+4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]	0.4387363448479504	0.4537498451909429	0.6500088863003306	1.0	0.6941992137484163	4	Q16134,O00217,P21912	3
+Glutaredoxin, PICOT-like [IPR033658]	0.4269696075538661	0.4283677027560882	0.6683834348786704	1.0	0.7129775132420716	2	O76003	1
+LIS1 homology motif [IPR006594]	0.4486418013738457	0.4140197991086786	0.6788596069082131	1.0	0.7238668736645587	13	Q9BZK7,Q96S59,Q9NWU2,Q7Z3E5,Q7L5Y9	5
+SAM-dependent methyltransferase RsmB/NOP2-type [IPR001678]	0.4203069657615119	0.3918815831840747	0.6951457113347601	1.0	0.7383190691928152	3	Q08J23,Q96P11	2
+SANT/Myb domain [IPR001005]	0.4384816065241295	0.3804126137324375	0.7036391527959802	1.0	0.745581565041074	12	Q96L91	1
+L27 domain [IPR004172]	0.4224679866748974	0.3795246290105851	0.7042983185855469	1.0	0.7459874781725393	5	Q14168	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.414994096812286	0.3717569363463098	0.7100738291107289	1.0	0.7515156624587503	3	Q9BUJ2,Q1KMD3	2
+Exportin-2, central domain [IPR013713]	0.4142710354629201	0.3690462870991476	0.7120932239601203	1.0	0.7533578273845908	3	O95373	1
+Transcription factor IIS, N-terminal [IPR017923]	0.4165730134242542	0.3673310499169421	0.7133720959906784	1.0	0.7544154220613749	4	Q14241,P23193	2
+mRNA splicing factor Cwf21 domain [IPR013170]	0.4066096193567456	0.351241339090421	0.7254072992125042	1.0	0.7656447353406979	2	O15042	1
+Sec23/Sec24, helical domain [IPR006900]	0.4116997267024505	0.3491575788018771	0.7269710116327379	1.0	0.7660981565646091	4	O95486	1
+Sec23/Sec24, trunk domain [IPR006896]	0.4116997267024505	0.3491575788018771	0.7269710116327379	1.0	0.7660981565646091	4	O95486	1
+Zinc finger, Sec23/Sec24-type [IPR006895]	0.4116997267024505	0.3491575788018771	0.7269710116327379	1.0	0.7660981565646091	4	O95486	1
+Sec23/Sec24 beta-sandwich [IPR012990]	0.4116997267024505	0.3491575788018771	0.7269710116327379	1.0	0.7660981565646091	4	O95486	1
+Peptidase M16, N-terminal [IPR011765]	0.4182205539433438	0.3443011179089323	0.7306198436590183	1.0	0.7693432648350225	7	Q10713,P22695	2
+Peptidase M16, C-terminal [IPR007863]	0.4182205539433438	0.3443011179089323	0.7306198436590183	1.0	0.7693432648350225	7	Q10713,P22695	2
+FAD/NAD(P)-binding domain [IPR023753]	0.4094100055669736	0.330679687073574	0.7408864472777863	1.0	0.778939758966762	5	P00390,O95831	2
+Zinc finger, CCHC-type [IPR001878]	0.4115239906411832	0.3194843259367252	0.7493592752142031	1.0	0.7872351328261185	7	Q9NUD5,Q9BWF3	2
+Ubiquitin-conjugating enzyme E2 [IPR000608]	0.4092931836433575	0.29388302002359	0.768847293532603	1.0	0.8061410116899856	9	Q9C0C9,P68036,P60604	3
+Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]	0.3897904986721827	0.2917857311176837	0.7704504556584386	1.0	0.806921039152173	2	O00154	1
+Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]	0.3956669688967146	0.291737741070292	0.7704871506338291	1.0	0.806921039152173	4	Q9NRF9	1
+Proteasome activator PA28, N-terminal domain [IPR003185]	0.3904958677685988	0.2839995554531266	0.7764107213201381	1.0	0.8118660096776367	3	P61289,Q06323	2
+Proteasome activator PA28, C-terminal domain [IPR003186]	0.3904958677685988	0.2839995554531266	0.7764107213201381	1.0	0.8118660096776367	3	P61289,Q06323	2
+Histone-binding protein RBBP4, N-terminal [IPR022052]	0.3902007083825327	0.2829966909929236	0.7771793735730239	1.0	0.8123553839049558	3	Q09028,Q9BQ67	2
+Gelsolin-like domain [IPR007123]	0.3931406876516926	0.2732494451444667	0.7846614738809641	1.0	0.8192253873363079	5	O95486	1
+R3H domain [IPR001374]	0.3866587957497025	0.2710702197985814	0.7863370255147417	1.0	0.8206576450138402	3	O95453,Q9H6S0	2
+Rab-GTPase-TBC domain [IPR000195]	0.3905246116894547	0.2643980147763102	0.791473241095497	1.0	0.8250619974691484	5	O60343,Q9Y3P9	2
+Ribose-phosphate pyrophosphokinase, N-terminal domain [IPR029099]	0.3842975206611587	0.263231381682151	0.7923722443719807	1.0	0.8256806032753922	3	Q14558,P11908	2
+EH domain [IPR000261]	0.3808498700749177	0.2233171761901332	0.8232886601257423	1.0	0.8539447062033612	6	P42566,Q9H223,Q9H4M9	3
+G-patch domain [IPR000467]	0.4013762242480393	0.2191196008264488	0.8265568825163183	1.0	0.8570056395084774	15	Q92917,Q8N1G2	2
+Homeobox domain [IPR001356]	0.3667133119129012	0.1891694382105096	0.8499600199487118	1.0	0.8770476790844606	5	Q96G23	1
+Clp ATPase, C-terminal [IPR019489]	0.3514311006196497	0.1733584683606604	0.8623696682212652	1.0	0.8876658451557556	2	Q9H078	1
+Metallo-beta-lactamase [IPR001279]	0.3575435488633095	0.1719138137425614	0.8635052864740815	1.0	0.8881580830045559	4	Q9UKF6,Q9NV88,Q5TA45	3
+EF-hand domain [IPR002048]	0.4154760461044348	0.1647980143183803	0.8691029670176698	1.0	0.8928958999550356	47	P80303,P60660,Q9H4M9,Q9Y680,O43852,Q14257,Q9H223,P14649,P17655,Q9BRK5,O75071,P07384	12
+NOSIC [IPR012976]	0.3491735537190044	0.1580721598701921	0.8743999379810459	1.0	0.8973143305829039	3	Q9Y2X3,Q8WWY3	2
+Nop domain [IPR002687]	0.3491735537190044	0.1580721598701921	0.8743999379810459	1.0	0.8973143305829039	3	Q9Y2X3,Q8WWY3	2
+Glutamine amidotransferase [IPR017926]	0.348686152937712	0.1478484145300924	0.8824623998977299	1.0	0.905244268991521	4	P27708,P17812,Q9NRF8	3
+Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]	0.3413986426674515	0.1467998533290995	0.883290000456469	1.0	0.9054057591932396	2	Q9H993	1
+Transcription elongation factor S-II, central domain [IPR003618]	0.3423848878394395	0.1403929756673826	0.8883495074941021	1.0	0.9092122610791908	3	P23193,Q9BTC0	2
+Pleckstrin homology domain [IPR001849]	0.3881078365441616	0.1137387419115828	0.9094449001801104	1.0	0.9259637470700158	25	O60333,P31751,P31749,Q9UQ16	4
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.3482658403947912	0.0986082340415447	0.9214493320683668	1.0	0.93740816839184	10	Q9Y680	1
+DnaJ domain [IPR001623]	0.3592574675687746	0.084397857816252	0.9327401104262768	1.0	0.9467557394334336	16	Q99543,O60884,Q8IXB1	3
+Forkhead-associated (FHA) domain [IPR000253]	0.3372209837661696	0.0654907070904053	0.9477833051205198	1.0	0.9595018697773114	11	Q5SW79,O60934	2
+von Willebrand factor, type A [IPR002035]	0.315898345153677	0.0499159100808083	0.9601893986971256	1.0	0.9716972866215856	7	Q9NU22,P55036,P13010,Q99829,A3KMH1,O75131	6
+W2 domain [IPR003307]	0.3127365702435029	0.0440749810288295	0.9648446356460394	1.0	0.97604275758727	7	P55010	1
+Ribosomal protein L7Ae/L30e/S12e/Gadd45 [IPR004038]	0.2971245180355668	0.0317113126566583	0.974702273229501	1.0	0.9852770453670452	5	Q9NX24	1
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.289259097704569	0.0200132745399511	0.9840327831352216	1.0	0.9939650766472408	5	P23634	1
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.289259097704569	0.0200132745399511	0.9840327831352216	1.0	0.9939650766472408	5	P23634	1
+B-box, C-terminal [IPR003649]	0.282433131881774	0.0174517808263163	0.9860762003066268	1.0	0.995656910772984	4	O15164	1
+Tudor domain [IPR002999]	0.2904728738303118	0.0023693983107175	0.9981094954383836	1.0	1.0	8	Q9Y2W6	1
+E3 ligase, CCCH-type zinc finger [IPR041367]	0.2629870129870194	0.0014108082732101	0.9988743382339684	1.0	1.0	3	Q9UPT8,Q86VM9	2

interpro_family/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome B-type subunit [IPR023333]"}

interpro_family/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome B-type subunit [IPR023333]"}

interpro_family/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:c4f2186897f4297ef7a49a22cbb0907dcf4b8dc08b2d4bbd8965a53bbbe977a7
+size 568498

interpro_family/df_merge.tsv

@@ -0,0 +1,4 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]	3	6	2.48325259861364	0.0130188732853997	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0603501083335805	0.0385773062479974	0.0743799864466655	0.014977467250991	0.0003286021100258
+Syntaxin [IPR045242]	4	7	2.335041660609379	0.0195412444864651	2.674757281553398	5.815533980582524	0.7134969984167514	0.3462495636510407	1.4434464182805606	1.4295601388514203	1.142372356309129	0.3001529293380739	1.0	1.0	1.0	0.0042425564235442	0.0003671727016274
+Proteasome B-type subunit [IPR023333]	6	7	2.1342527995170304	0.0328220927389082	3.699029126213592	6.970873786407767	1.6670727234653664	0.1509307531330224	1.4503762582219135	0.1681602725795027	0.9611878160538336	0.233503072382129	0.0676363609296167	1.0	0.0832836732680532	3.9104524570814734e-05	2.8311070051942505e-05

interpro_family/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3391,
+    "annotations_size": 2600,
+    "title": "Average number of proteins per term",
+    "value": 1.2873076923076923
+}

interpro_family/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_family/fragment/C281/C281_val_log2fc"}

interpro_family/result.tsv

@@ -0,0 +1,134 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Amyloidogenic glycoprotein [IPR008155]	0.9949837710239008	2.9526119307308445	0.0031509781139551	0.9997268467421376	0.0515133963185733	2	P05067	1
+Glycoside hydrolase, family 29 [IPR000933]	0.9864266745352608	2.917971256658083	0.0035231682474297	0.99989654894687	0.0515133963185733	2	P04066	1
+Alpha-L-fucosidase, metazoa-type [IPR016286]	0.9864266745352608	2.917971256658083	0.0035231682474297	0.99989654894687	0.0515133963185733	2	P04066	1
+Palmitoyl protein thioesterase [IPR002472]	0.9846562407789898	2.910786068746985	0.0036052076969694	0.9999164844330112	0.0515133963185733	2	Q9UMR5	1
+Peptidase S10, serine carboxypeptidase [IPR001563]	0.9802243211334112	2.88985650263711	0.0038541771539086	0.9999563898854285	0.0515133963185733	3	Q9HB40,Q9H3G5	2
+Lysosome-associated membrane glycoprotein [IPR002000]	0.979049867217468	2.887991751559385	0.003877100394259	0.9999589226285728	0.0515133963185733	2	P13473	1
+Beta-hexosaminidase [IPR025705]	0.9772794334611968	2.880780499273083	0.0039669179765118	0.9999675074060128	0.0515133963185733	2	P06865	1
+Transmembrane protein GPR107/GPR108-like [IPR009637]	0.9737308146399046	2.863278494795097	0.0041928185899309	0.9999819839235438	0.0515133963185733	3	Q8NBN3,Q9NPR9	2
+Tetraspanin/Peripherin [IPR018499]	0.961345529654761	2.8155958390688927	0.0048686872846679	0.999996916677096	0.0515133963185733	2	O60637	1
+Carbohydrate sulfotransferase 8-10 [IPR018011]	0.9578046621422216	2.8010407442855954	0.0050938087246266	0.9999982878293784	0.0515133963185733	2	Q8NCH0	1
+Sulfotransferase [IPR005331]	0.9580873671782744	2.798899811311701	0.0051277044922419	0.9999984329729592	0.0515133963185733	3	Q7LGA3,Q8NCH0	2
+CD36 family [IPR002159]	0.9492475656535804	2.7657607685099466	0.0056790179678092	0.9999996291739488	0.0515133963185733	2	Q14108	1
+Desmosomal cadherin [IPR009122]	0.945706698141039	2.7511184974004985	0.0059392154752901	0.999999812220828	0.0515133963185733	2	Q14574	1
+Nonaspanin (TM9SF) [IPR004240]	0.9456906729633996	2.7475288475338147	0.0060046226388694	0.9999998417483712	0.0515133963185733	3	Q99805,Q92544	2
+Beta-1,4-galactosyltransferase [IPR003859]	0.938920035408676	2.7229824322331795	0.0064695498035527	0.9999999531107272	0.0515133963185733	2	O60512	1
+P-type ATPase, subfamily IB [IPR027256]	0.9215107701386782	2.6503740404427516	0.0080402701790021	0.9999999992335068	0.0516692669288985	2	P35670	1
+Peptidase C2, calpain family [IPR022684]	0.9161994688698668	2.628097555756389	0.0085863887379842	0.9999999998169034	0.0516692669288985	2	P17655	1
+Exostosin-like [IPR004263]	0.9126586013573256	2.613214019669035	0.0089695114549768	0.9999999999329744	0.0516694094713659	2	Q93063	1
+Aminopeptidase N-type [IPR034016]	0.9096545615589108	2.5926826621178605	0.0095230595725133	0.9999999999843197	0.0516694094713659	4	Q9UIQ6,Q6P179,Q9NZ08	3
+Mitochondrial inner membrane translocase complex, subunit Tim17 [IPR005678]	0.9067571555030924	2.588350140946572	0.0096436898619223	0.9999999999885756	0.0518770192989541	2	O60830	1
+ATPase, V0 complex, subunit 116kDa, eukaryotic [IPR026028]	0.9035113602832644	2.574644058560498	0.0100343290443101	0.999999999995904	0.0521588821268782	2	Q93050	1
+V-type  ATPase, V0 complex, 116kDa subunit family [IPR002490]	0.9035113602832644	2.574644058560498	0.0100343290443101	0.999999999995904	0.0521588821268782	2	Q93050	1
+Nucleosome assembly protein (NAP) [IPR002164]	0.898435193386481	2.5448728597086787	0.010931753296318	0.9999999999996124	0.0533256258356976	4	Q9H0U9,Q99733,Q01105	3
+Integrin alpha chain [IPR000413]	0.8940690469164958	2.5346466424951988	0.0112560804098573	0.9999999999998348	0.0538369273673728	2	P23229	1
+Chloride channel, voltage gated [IPR001807]	0.8919716646989307	2.521248189040821	0.0116939339469988	0.9999999999999478	0.0542788059847354	3	P51797,P51790	2
+Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase [IPR001930]	0.8857290110049938	2.48325259861364	0.0130188732853997	0.9999999999999984	0.0557266805210261	6	Q9UIQ6,Q6P179,Q9NZ08	3
+Nucleobindin [IPR040250]	0.880790793744457	2.4780841875287347	0.0132089974072806	0.999999999999999	0.0557266805210261	2	P80303	1
+Prolyl 4-hydroxylase [IPR045054]	0.8772499262319238	2.462938325151771	0.0137803617904346	0.9999999999999998	0.0566913617960918	2	O15460	1
+Peptidase T1A, proteasome beta-subunit [IPR000243]	0.8730171756676008	2.439963732221234	0.0146887365045584	1.0	0.0578647195634122	3	P28074	1
+SCAMP [IPR007273]	0.8548244319858392	2.3664017219739253	0.0179619424408217	1.0	0.0629510235162953	2	O15126	1
+Syntaxin [IPR045242]	0.8524900586568954	2.335041660609379	0.0195412444864651	1.0	0.0656424233395468	7	O43752,Q13277,O15400,Q13190	4
+Ergosterol biosynthesis ERG4/ERG24 [IPR001171]	0.8436116848627789	2.317736282944104	0.0204636578498489	1.0	0.0670278658317174	2	Q9UBM7	1
+Zinc transporter Msc2-like [IPR045316]	0.8191206845677113	2.2105223591058833	0.0270689305088538	1.0	0.0771974335187967	2	Q8TAD4	1
+Cation efflux protein [IPR002524]	0.8191206845677113	2.2105223591058833	0.0270689305088538	1.0	0.0771974335187967	2	Q8TAD4	1
+Ras-related protein Ral [IPR028412]	0.8164650339333165	2.1988213546570754	0.027890627447918	1.0	0.0783175720887433	2	P11234	1
+Endoplasmic reticulum vesicle transporter [IPR045888]	0.8166395100256003	2.1937131521989595	0.0282560377114833	1.0	0.0786742365020628	3	Q9Y282	1
+Acidic leucine-rich nuclear phosphoprotein 32 [IPR045081]	0.8143995278843361	2.1897104219831935	0.0285452447618708	1.0	0.0790390163800469	2	Q9BTT0	1
+Mpv17/PMP22 [IPR007248]	0.8111537326644886	2.1753753248724705	0.0296020020396838	1.0	0.0809308152504501	2	Q567V2	1
+Flotillin family [IPR027705]	0.8090882266155134	2.1662416068629864	0.0302927292527859	1.0	0.0820428083929618	2	O75955	1
+Peptidase M20 [IPR002933]	0.8067276482738276	2.155792249979711	0.0310998909163167	1.0	0.0831035111844023	2	Q8IYS1	1
+ER lumen protein retaining receptor [IPR000133]	0.8028917084685574	2.1387874760805117	0.0324528842142362	1.0	0.0855755567515356	2	O43731	1
+Proteasome B-type subunit [IPR023333]	0.8076241134751982	2.1342527995170304	0.0328220927389082	1.0	0.0861631067240123	7	P28070,P49721,P49720,P20618,P28074,P28072	6
+Ribonucleotide reductase small subunit [IPR033909]	0.8017114192977288	2.1335491302584386	0.032879705869266	1.0	0.0861631067240123	2	Q7LG56	1
+Ribonucleotide reductase small subunit family [IPR000358]	0.8017114192977288	2.1335491302584386	0.032879705869266	1.0	0.0861631067240123	2	Q7LG56	1
+Tropomyosin [IPR000533]	0.8027401479636511	2.131978037439098	0.0330086520971701	1.0	0.0862351520959014	3	P09493	1
+Sodium/potassium-transporting ATPase subunit beta [IPR000402]	0.7964001180289203	2.109941111480081	0.0348634285434488	1.0	0.0889744549643089	2	P54709	1
+H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote [IPR002415]	0.7913838890528202	2.08759155896952	0.0368346940813428	1.0	0.0912966678851205	2	Q9NX24	1
+Peptidase M3A/M3B [IPR045090]	0.7759740259740138	2.011975894918629	0.0442224780554134	1.0	0.1010922638984633	3	Q9BYT8,P52888	2
+Translation Initiation factor eIF- 4e [IPR001040]	0.7716140454411362	1.9990114997876371	0.045607109624919	1.0	0.1031117261085127	2	O60573	1
+P-type ATPase, subfamily IIB [IPR006408]	0.7710239008557143	1.9963552793482344	0.0458952649240824	1.0	0.103493225327506	2	P23634	1
+Rho-associated protein kinase 1/2 [IPR020684]	0.7459427559752159	1.8828370672236316	0.0597224520026844	1.0	0.1232561135816692	2	Q13464	1
+Small GTPase, Ras-type [IPR020849]	0.7447075693026417	1.8631827390641416	0.0624365605185155	1.0	0.1274215520786031	4	P11234,P11233	2
+Coatomer gamma subunit [IPR017106]	0.7400413101209835	1.8559522920521156	0.0634603584665562	1.0	0.1288927371802736	2	Q9UBF2	1
+Nucleoside diphosphate kinase [IPR001564]	0.7390687253029664	1.8441856109907555	0.0651560946276488	1.0	0.1305129784529175	3	O75414	1
+ADP-ribosylation factor 1-5 [IPR045872]	0.7370905871938416	1.842485656021252	0.065404142769669	1.0	0.130808285539338	2	P84085	1
+Luc7-related [IPR004882]	0.7260920897284546	1.7845787622991032	0.0743296687826506	1.0	0.140977128463653	3	Q9Y383,Q9NQ29	2
+CTP synthase [IPR004468]	0.699026261434052	1.667391428386488	0.0954365971676423	1.0	0.1641105506850992	2	P17812	1
+THRAP3/BCLAF1 family [IPR029199]	0.6987311891413421	1.6660247029595558	0.095708494313909	1.0	0.1641438556834851	2	Q9Y2W1	1
+Prenylated rab acceptor PRA1 [IPR004895]	0.6980519480519375	1.654787330441743	0.097967644857277	1.0	0.1666988721393457	3	O75915,O60831	2
+Dynamin [IPR022812]	0.6966083757128174	1.640355415165983	0.1009312897827439	1.0	0.1693040989904091	4	Q9UQ16	1
+Tubulin [IPR000217]	0.6943209065199312	1.6151929971341814	0.1062689066034392	1.0	0.1745356984556783	6	P23258,Q13885,Q9BUF5	3
+DNA mismatch repair MutS family [IPR045076]	0.6794569067296322	1.5680381170984052	0.1168722369890513	1.0	0.1864219731113702	3	P52701,P20585	2
+P-type ATPase [IPR001757]	0.6820134862686268	1.5346190563626263	0.1248774289329683	1.0	0.194653066682085	10	P35670,Q04656,Q9NQ11,Q8NB49	4
+Rab GDI protein [IPR000806]	0.6683387429920346	1.5245740589790655	0.1273653717790313	1.0	0.1968786959723432	2	P31150	1
+GDP dissociation inhibitor [IPR018203]	0.6683387429920346	1.5245740589790655	0.1273653717790313	1.0	0.1968786959723432	2	P31150	1
+AP complex subunit beta [IPR026739]	0.6664168072811129	1.5069240532196138	0.1318301252437246	1.0	0.201978977980957	3	Q10567	1
+Ezrin/radixin/moesin [IPR011174]	0.6519069355790504	1.438690337008073	0.1502382783386799	1.0	0.2209340488125296	3	P15311	1
+Graves disease carrier protein [IPR002167]	0.6485688993803435	1.43194087101989	0.15216074408879	1.0	0.2226324899442059	2	Q6KCM7	1
+Beta tubulin [IPR002453]	0.6535735380980442	1.4298436710501838	0.1527618919201394	1.0	0.2228884117545675	5	Q13885,P04350,P68371,Q9BUF5	4
+Proteasome, subunit alpha/beta [IPR001353]	0.6619972167372885	1.4205280533229394	0.1554540074372852	1.0	0.2254003292572067	14	P49721,P28074,P28072	3
+14-3-3 protein [IPR000308]	0.6515615639859479	1.4124563950241285	0.1578156212857457	1.0	0.2278293255652076	6	P31946,P62258,Q04917	3
+Tyrosine-tRNA ligase [IPR002307]	0.6417822366479817	1.4000525382247573	0.1614975862156538	1.0	0.2312190111017069	2	Q9Y2Z4	1
+Glycosyl transferase, family 35 [IPR000811]	0.6400118028917113	1.3917275581506592	0.1640049138925383	1.0	0.2330671800157454	2	P11216	1
+Glycogen/starch/alpha-glucan phosphorylase [IPR011833]	0.6400118028917113	1.3917275581506592	0.1640049138925383	1.0	0.2330671800157454	2	P11216	1
+ClpA/B family [IPR001270]	0.6335202124520366	1.3611828398581818	0.1734559157112822	1.0	0.2418152176135838	2	Q9H078	1
+Importin beta family [IPR040122]	0.6284760108340741	1.310529689207774	0.190016707326396	1.0	0.2582558489538054	5	O00410,O60518,Q8TEX9	3
+KH domain-containing BBP-like [IPR045071]	0.6190112458795707	1.283348310712067	0.1993700742981135	1.0	0.2671970067912861	3	Q15637	1
+Ras GTPase-activating protein-binding protein [IPR039539]	0.6093242844496962	1.2471422216465102	0.2123453539315543	1.0	0.2784257367941565	2	Q9UN86	1
+RNA-binding protein 26/27 [IPR045137]	0.6078489229861379	1.240183263929988	0.2149076171850887	1.0	0.2803611664230963	2	Q9P2N5	1
+Cyclophilin-type peptidyl-prolyl cis-trans isomerase [IPR024936]	0.6013573325464805	1.2095635326425718	0.2264464185054651	1.0	0.2900298956227631	2	Q9Y3C6	1
+Cullin [IPR045093]	0.6039269850572064	1.1848846972188567	0.2360630386224949	1.0	0.2982331877640849	6	Q13619,Q13620	2
+SNX17/27/31 [IPR037831]	0.582472705812932	1.12054571970899	0.262481281085593	1.0	0.3223671850838648	2	Q15036	1
+Mitofusin family [IPR027094]	0.5694895249336112	1.0594788803846895	0.2893817425831804	1.0	0.3443444076504663	2	O95140	1
+CPSF6/7 family [IPR034772]	0.568899380348193	1.0567071879891845	0.2906452434802913	1.0	0.3453736896932163	2	Q16630	1
+Sister chromatid cohesion protein Pds5 [IPR039776]	0.5624077899085358	1.0262478021073675	0.3047747944696559	1.0	0.355502227734906	2	Q9NTI5	1
+DNA-directed DNA polymerase, family B [IPR006172]	0.5628689492325756	1.0181062245965071	0.3086274775383559	1.0	0.3582283221427346	3	P28340,P09884	2
+Ribosomal protein L7Ae/L8/Nhp2 family [IPR018492]	0.5561957248722673	0.9867704490316151	0.3237551846528088	1.0	0.3701198046542581	3	Q9NX24	1
+Small GTPase superfamily, ARF/SAR type [IPR006689]	0.5663953606005666	0.9747640078246156	0.3296773343846975	1.0	0.3738164279983486	10	Q96BM9,Q9Y6B6	2
+Transmembrane protein 126 [IPR009801]	0.5479492475656591	0.9586440884711656	0.33773807398491	1.0	0.380962686490571	2	Q9H061	1
+NudC family [IPR037898]	0.5326054883446555	0.8873853220040536	0.3748714832060114	1.0	0.4103876440860472	2	Q8IVD9	1
+HnRNP R/Q splicing factor [IPR006535]	0.5302449100029551	0.8764777548643657	0.3807703644187779	1.0	0.4137078760922785	2	O43390	1
+Histidine phosphatase superfamily, clade-1 [IPR013078]	0.5221418941104098	0.828426647400144	0.4074289205663002	1.0	0.4313172611858227	3	Q96HS1	1
+Bicarbonate transporter, eukaryotic [IPR003020]	0.5113602832694024	0.7898841322132609	0.4295954390875227	1.0	0.4462161238511163	2	Q9Y6M7	1
+Ubiquitin-activating enzyme E1 [IPR018075]	0.5101799940985653	0.7845167293610228	0.4327369695294556	1.0	0.448432092776638	2	A0AVT1	1
+Ribosomal protein S8e/ribosomal biogenesis NSA2 [IPR022309]	0.5092947772204303	0.7804950320848948	0.4350995505658637	1.0	0.4504704620571895	2	O95478	1
+Ubiquitin/SUMO-activating enzyme E1 [IPR000011]	0.5103305785123946	0.7743698827190693	0.4387120885153219	1.0	0.4531789551608411	3	A0AVT1,Q9UBE0	2
+Ribosomal protein L25/L23 [IPR013025]	0.5066391265860163	0.7684502564607987	0.4422197326423567	1.0	0.4566208518149831	2	P62750	1
+Actin-related protein 2/3 complex subunit 1 [IPR017383]	0.4986721746828009	0.7325098298208093	0.4638574451889878	1.0	0.4776353891054924	2	Q92747	1
+Mesoderm induction early response protein/metastasis-associated protein [IPR040138]	0.4963115963411121	0.7219203630996343	0.4703434409166638	1.0	0.4837392984111257	2	Q13330	1
+ATP-dependent 6-phosphofructokinase, eukaryotic-type [IPR009161]	0.4973435655253804	0.7156396588689532	0.4742138786639414	1.0	0.4871418745658821	3	P08237,Q01813	2
+ATP-dependent 6-phosphofructokinase, vertebrate-type [IPR041914]	0.4973435655253804	0.7156396588689532	0.4742138786639414	1.0	0.4871418745658821	3	P08237,Q01813	2
+ATP-dependent 6-phosphofructokinase [IPR022953]	0.4973435655253804	0.7156396588689532	0.4742138786639414	1.0	0.4871418745658821	3	P08237,Q01813	2
+ADP-ribosylation factor-like protein 2/3 [IPR044612]	0.4930658011212873	0.7074072686089102	0.4793134212081398	1.0	0.4921859775439035	2	P36404	1
+Histone deacetylase [IPR003084]	0.4918855119504265	0.702143832649703	0.4825894692008967	1.0	0.4951588871043139	2	Q13547	1
+Histone deacetylase family [IPR000286]	0.4918855119504265	0.702143832649703	0.4825894692008967	1.0	0.4951588871043139	2	Q13547	1
+Alanine-tRNA ligase, class IIc [IPR002318]	0.4892298613160342	0.6903294138807042	0.4899870545887217	1.0	0.5023526584900143	2	P49588	1
+Alanine-tRNA ligase, eukaryota/bacteria [IPR023033]	0.4892298613160342	0.6903294138807042	0.4899870545887217	1.0	0.5023526584900143	2	P49588	1
+Aldo-keto reductase [IPR020471]	0.4791974033638324	0.6460738908538882	0.5182315032712097	1.0	0.5308912169051005	2	P14550	1
+Inosine-5'-monophosphate dehydrogenase [IPR005990]	0.4786072587784054	0.6434902875601908	0.5199060149096097	1.0	0.5323968644210261	2	P12268	1
+Dynein light chain, type 1/2 [IPR001372]	0.4762466804367167	0.6331789606256825	0.5266167833734925	1.0	0.5388444064427708	2	Q96FJ2	1
+Ribosomal protein L3 [IPR000597]	0.4668043670699419	0.5923226654511534	0.5536345411397807	1.0	0.5660439665605308	2	P39023	1
+ThiF/MoeB/HesA family [IPR045886]	0.4787823710278919	0.5838760288313214	0.5593037218440409	1.0	0.5711664087959569	8	Q13564	1
+Cohesin subunit Scc3/SA [IPR039662]	0.4591324874594386	0.5596227391599229	0.5757367913174833	1.0	0.5877171799864376	2	Q8WVM7	1
+Developmentally regulated GTP-binding protein [IPR045001]	0.4547064030687548	0.5409771307590003	0.5885233457389152	1.0	0.6000630191847763	2	P55039	1
+Major facilitator superfamily [IPR011701]	0.4628683002218449	0.5332940815440047	0.5938300239610754	1.0	0.6052364023123465	6	Q7L0J3,Q14728	2
+Adenylate kinase 3/4, mitochondrial [IPR028586]	0.4499852463853669	0.5212771423068495	0.6021737217872734	1.0	0.613019450527373	2	Q9UIJ7	1
+ATP-dependent RNA helicase Ski2-like [IPR016438]	0.4496901740926691	0.5200525842847628	0.6030269251359694	1.0	0.6136477516060747	2	Q15477	1
+Heat shock protein Hsp90 family [IPR001404]	0.4511366991437895	0.5044929690522713	0.6139150017144583	1.0	0.6244831785827824	4	P08238,Q12931,P07900	3
+G-protein alpha subunit, group I [IPR001408]	0.4346414871643547	0.4587206995567638	0.6464347475070258	1.0	0.656278931479214	2	P08754	1
+Pre-mRNA-splicing factor Syf1-like [IPR045075]	0.4356552538370762	0.4519489485174134	0.6513057605484118	1.0	0.6609660333434312	3	Q9HCS7,Q9BZJ0	2
+Monothiol glutaredoxin-related [IPR004480]	0.4269696075538661	0.4283677027560882	0.6683834348786704	1.0	0.6777679136835191	2	O76003	1
+Basigin-like [IPR043204]	0.4216583062850362	0.4077494639858219	0.6834576187296526	1.0	0.6925135653535062	2	P35613	1
+RNA (C5-cytosine) methyltransferase [IPR023267]	0.4203069657615119	0.3918815831840747	0.6951457113347601	1.0	0.7038079631893989	3	Q08J23,Q96P11	2
+Paraneoplastic encephalomyelitis antigen [IPR002343]	0.4104455591619919	0.3653644100300396	0.7148394042755071	1.0	0.7226214817715079	2	O95319	1
+TAF15/EWS/TLS family [IPR034870]	0.412337662337666	0.3618323329901504	0.7174773286940939	1.0	0.7250062396442457	3	Q01844,P35637	2
+Proteasome activator PA28 [IPR009077]	0.3904958677685988	0.2839995554531266	0.7764107213201381	1.0	0.7824294090823097	3	P61289,Q06323	2
+Ribose-phosphate pyrophosphokinase [IPR005946]	0.3842975206611587	0.263231381682151	0.7923722443719807	1.0	0.7982052829783611	3	Q14558,P11908	2
+Profilin [IPR005455]	0.3502508114488002	0.1701337181734154	0.8649049767887156	1.0	0.868915355351878	2	P35080	1
+Profilin1/2/3, vertebrate [IPR005454]	0.3502508114488002	0.1701337181734154	0.8649049767887156	1.0	0.868915355351878	2	P35080	1
+Cyclin [IPR039361]	0.3363824136913529	0.1342543808352893	0.8932014254025513	1.0	0.8959582199253987	2	P14635	1
+Guanine nucleotide binding protein (G-protein), alpha subunit [IPR001019]	0.337271116361498	0.1106929028382559	0.9118598741082032	1.0	0.9139690334160868	5	Q14344,P04899,P29992,P08754	4
+UDPGP family [IPR002618]	0.317497786957801	0.091517892715297	0.927081089565446	1.0	0.9277947778561044	2	Q16222	1
+Small GTPase Rho [IPR003578]	0.2950796685248739	0.0216435286400698	0.9827323108200824	1.0	0.9831104302163196	6	P63000,P60953,P61586	3