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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:ca71291e1c0dc0fba8a9331e8e2f33b5fd6048942bebb0f3bbe5b3fb355effa8
+size 75542

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3220,
+    "annotations_size": 57,
+    "title": "Average number of proteins per term",
+    "value": 2.508771929824561
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C288/C288_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,5 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Serine carboxypeptidase, serine active site [IPR018202]	0.9664283493938438	1.7825411912754807	0.0746610202450503	0.988000894913337	0.2492940841252635	3	Q9H3G5,P10619	2
+Histidine acid phosphatase active site [IPR033379]	0.9136109384710944	1.0865083004233045	0.2772541706300853	0.9999999908340208	0.5267829241971621	2	Q9NPH0	1
+Ribonucleotide reductase small subunit, acitve site [IPR030475]	0.8660658794282167	0.915217093567991	0.3600776726613151	0.9999999999911028	0.6036596276969106	2	Q7LG56	1
+Peptidase S9, serine active site [IPR002471]	0.4984462399005683	0.0677261646104475	0.9460036207791548	1.0	0.9804037524438516	2	P48147	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "DNA topoisomerase, type IA, active site [IPR023406]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Lipase, GDXG, putative serine active site [IPR033140]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine proteases, trypsin family, histidine active site [IPR018114]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT2", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "BLMH", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK13", "CDK2", "CDK4", "CDK6", "CHEK2", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3A", "GSK3B", "GSR", "HADHB", "HMGCL", "HMGCS1", "LDHA", "LDHB", "LONP1", "LYN", "MAP2K1", "MAP2K2", "MAP3K7", "MAPK1", "MAPK3", "MAPKAPK2", "MDH1", "MDH2", "MTMR2", "NCEH1", "NEK9", "NME1", "NME2", "OXCT1", "PAK1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKMYT1", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA2", "PRKACA", "PRPF4B", "PRSS3", "PTK7", "PTPMT1", "PTPN1", "PTPN11", "PTPN23", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "RRM2B", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TAOK2", "TIGAR", "TOP1", "TOP3A", "TPI1", "TPP2", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "ULK3", "UMPS", "VRK1", "VRK2", "WNK1"], "leading_proteins": ["ACP6", "CPVL", "CTSA", "PREP", "RRM2B"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:093bb5e99a81ef39f0229ef125b944feb87e5247ccb98908f91345a402a7f0d4
+size 73626

interpro_binding_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Peptidase M16, zinc-binding site [IPR001431]	2	5	2.313795026612107	0.0206789683137311	1.730582524271845	5.0	0.6776547957610433	0.4740055886775391	1.2118895823030245	0.0	0.8079860258854747	0.314626832259423	0.0002685484719454	1.0	1.0	0.0055254488719224	0.0010568895936515

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3220,
+    "annotations_size": 32,
+    "title": "Average number of proteins per term",
+    "value": 4.5
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C288/C288_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,4 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Peptidase M16, zinc-binding site [IPR001431]	0.8847662535282672	2.313795026612107	0.0206789683137311	0.4876076873603735	0.1323453972078795	5	Q10713,P22695	2
+Beta tubulin, autoregulation binding site [IPR013838]	0.646147672788906	1.498761826334304	0.1339354310326141	0.9899628896721856	0.3896303448221503	7	P68371,Q13509,P04350,Q9BVA1	4
+EF-Hand 1, calcium-binding site [IPR018247]	0.3890003235353017	0.7193464935681821	0.4719274557636743	0.9999999986628048	0.7634011248249627	39	Q9NWM8,Q02818,Q14257,Q9Y680,P41208,P80303	6

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "APOBEC3C", "ARG2", "BPNT1", "CALM3", "CALU", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDK1", "CDK13", "CDK2", "CDK4", "CDK6", "CETN2", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "FKBP9", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "ILKAP", "IQGAP1", "IQGAP2", "LETM1", "LPCAT2", "LYN", "MACF1", "MAP2K1", "MAP2K2", "MAP3K7", "MAP4K5", "MAPK1", "MAPK14", "MAPK3", "MAPKAPK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH9", "MYO19", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK1", "PAK2", "PC", "PCCA", "PDCD6", "PDHX", "PEF1", "PGD", "PKMYT1", "PKN1", "PKN2", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1F", "PPM1G", "PRKAA2", "PRKACA", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK26", "STK4", "TAOK2", "TKT", "TTK", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "ULK3", "UQCRC2", "VRK1"], "leading_proteins": ["CETN2", "FKBP14", "FKBP7", "NUCB1", "NUCB2", "PMPCA", "RCN2", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "UQCRC2"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]"}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "Intermediate filament protein, conserved site [IPR018039]", "2": "Tubulin, conserved site [IPR017975]", "3": "Guanylate kinase, conserved site [IPR020590]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:05d9378c0de4410d9282704f2fdccb61c3eb607c189a45459340b99d6a64156b
+size 86318

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,3 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Proteasome beta-type subunit, conserved site [IPR016050]	5	8	2.234349168086861	0.0254601075386344	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	0.0028755778106474	0.0479914252810258	0.0938999510605359	0.0229613270793894	5.436360967141595e-05
+Syntaxin/epimorphin, conserved site [IPR006012]	2	8	2.234188050684015	0.0254707023443236	2.592233009708738	5.847087378640777	0.9961908981999794	0.2839139128702306	1.4759357288864456	1.4239341993278547	1.138258151200134	0.2914162845337057	0.0064033235801391	1.0	0.1203280145079081	0.0379575415698398	0.0225979674873623

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3220,
+    "annotations_size": 273,
+    "title": "Average number of proteins per term",
+    "value": 2.58974358974359
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C288/C288_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,33 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteasome beta-type subunit, conserved site [IPR016050]	0.7730992528416881	2.2343491680868612	0.0254601075386344	0.9991244183047322	0.2923526080479657	8	P49721,P28070,P20618,P28074,P28072	5
+Syntaxin/epimorphin, conserved site [IPR006012]	0.7730655198117725	2.234188050684015	0.0254707023443236	0.999127013145608	0.2923526080479657	8	Q9P2W9,O60499	2
+Tetraspanin, conserved site [IPR018503]	0.9459123406900792	1.706464136438597	0.0879216981132899	0.999999999987732	0.486266049431425	3	O43657,O60637	2
+Intermediate filament protein, conserved site [IPR018039]	0.6404541662383724	1.5779954314427866	0.1145666593601864	0.9999999999999962	0.5686672364605615	8	P07196,P07197,Q03252,Q16352,P08670	5
+Mini-chromosome maintenance, conserved site [IPR018525]	0.6694200735605436	1.511801943827527	0.1305842547743065	1.0	0.5954754224672094	6	Q14566,P25205,P49736	3
+Tubulin, conserved site [IPR017975]	0.6273349937733487	1.5107813116900932	0.1308441776533413	1.0	0.5954754224672094	8	Q9BUF5,P68371,P04350,P07437,Q9BVA1,Q13885,Q13509	7
+Thioredoxin, conserved site [IPR017937]	0.5382537124515046	1.3768652094353204	0.1685539252454422	1.0	0.6035171725209099	12	Q9H3N1,Q96JJ7,Q9H1E5	3
+Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]	0.8246583828887826	1.25257523720809	0.2103603314321018	1.0	0.6525951191018614	3	Q8N4Q0	1
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.906774394033561	1.0615888152566837	0.2884223935068983	1.0	0.734863949864907	2	Q9BTY2	1
+Sterol reductase, conserved site [IPR018083]	0.8523927905531207	0.8670110591486583	0.3859359502551789	1.0	0.8296103497611326	2	Q14739	1
+Lysosome-associated membrane glycoprotein, conserved site [IPR018134]	0.7967681789931663	0.6778642529468616	0.4978577670888873	1.0	0.8731492022257699	2	P11279	1
+Methylthiotransferase, conserved site [IPR020612]	0.7563704164076819	0.5498824401949363	0.5824000090088253	1.0	0.92439071197331	2	Q5VV42	1
+ABC transporter-like, conserved site [IPR017871]	0.4111541577629098	0.5070595621835099	0.6121130271979989	1.0	0.9559185943989472	10	O75027,P08183	2
+Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]	0.6821006836544513	0.3444047087538905	0.7305419481625663	1.0	0.9657910906995332	2	Q07820	1
+Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]	0.6821006836544513	0.3444047087538905	0.7305419481625663	1.0	0.9657910906995332	2	Q07820	1
+Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]	0.6821006836544513	0.3444047087538905	0.7305419481625663	1.0	0.9657910906995332	2	Q07820	1
+Mrp, conserved site [IPR000808]	0.6730888750776961	0.322701269845695	0.7469214903596411	1.0	0.9657910906995332	2	Q9Y5Y2	1
+Actin, conserved site [IPR004001]	0.6637663144810526	0.3010781127447693	0.7633549306271492	1.0	0.9662883416316188	2	P61163	1
+3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]	0.6522684897451922	0.2756049852373609	0.7828514802520401	1.0	0.969151424589004	2	Q16836	1
+Oxysterol-binding protein, conserved site [IPR018494]	0.4284825870646682	0.2388936149154728	0.8111880767968862	1.0	0.9808200903469538	4	Q9BXB4,P22059,Q9BZF1	3
+UbiE/COQ5 methyltransferase, conserved site [IPR023576]	0.6196395276569395	0.2108070429503086	0.833037842564105	1.0	0.9880594732118968	2	O43159	1
+HMG box A DNA-binding domain, conserved site [IPR017967]	0.4802611128380571	0.1713422479124139	0.863954662588599	1.0	0.9922042556917896	3	P09429,P26583	2
+Aldehyde dehydrogenase, cysteine active site [IPR016160]	0.354002562798601	0.13919734714711	0.8892942047668415	1.0	0.9936422891736566	7	P30837,P51648,Q02252	3
+Actin/actin-like conserved site [IPR020902]	0.4597451041342927	0.1371244336916003	0.890932439598566	1.0	0.9936422891736566	3	P61160,P61163	2
+Clathrin adaptor, mu subunit, conserved site [IPR018240]	0.4261734535281377	0.0919069537222774	0.926771966577046	1.0	0.9994334820820256	3	Q9BXS5,Q96CW1	2
+Heat shock protein Hsp90, conserved site [IPR019805]	0.4143612060926449	0.0790702144543827	0.9369767747379752	1.0	0.9994334820820256	3	P07900,P14625	2
+Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]	0.481354878806728	0.058303567505583	0.953506825892736	1.0	1.0	2	P06730	1
+Profilin conserved site [IPR027310]	0.4449968924798187	0.0444541761679887	0.9645423779606166	1.0	1.0	2	P35080	1
+Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]	0.4353635798632783	0.0419385785637804	0.9665476621919504	1.0	1.0	2	O60568	1
+Macrophage migration inhibitory factor, conserved site [IPR019829]	0.4322560596644014	0.0412126926328908	0.9671263350125628	1.0	1.0	2	P14174	1
+Guanylate kinase, conserved site [IPR020590]	0.3136278780335957	0.0221093140928971	0.982360756721395	1.0	1.0	6	Q5T2T1,O14936,Q9NZW5,Q14168,Q8N3R9	5
+Zinc finger, RING-type, conserved site [IPR017907]	0.3081936299252925	0.0150130648963117	0.988021757277507	1.0	1.0	9	O60858	1

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bax inhibitor 1, conserved site [IPR006213]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 14-18kDa subunit, conserved site [IPR020708]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Di-trans-poly-cis-decaprenylcistransferase-like, conserved site [IPR018520]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Endonuclease III-like, conserved site-2 [IPR004036]", "Endonuclease III-like, iron-sulphur cluster loop motif [IPR003651]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif [IPR000445]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RIO kinase, conserved site [IPR018935]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinate dehydrogenase, cytochrome b subunit, conserved site [IPR018495]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AAMP", "ABCB1", "ABCB10", "ABCB7", "ABCD1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA6", "ANXA7", "AP1M1", "AP1S1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "APP", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAX", "BAZ1A", "BAZ1B", "BCAT2", "BCS1L", "BOP1", "BPNT1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDK5RAP1", "CDKAL1", "CETN2", "CHAF1B", "CHD1L", "CHD4", "CLGN", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "COQ5", "CORO1B", "CORO1C", "CPOX", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4A", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHDDS", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJB12", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNM3", "DNMT1", "DPY30", "DRG1", "DRG2", "DSG2", "DTYMK", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP2", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GGPS1", "GLA", "GLB1", "GLO1", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUF1", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "ILVBL", "IMPAD1", "IMPDH2", "INA", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDSR", "KIF11", "KIF14", "KIF1A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGST2", "MID1", "MIF", "MPI", "MPP1", "MPP2", "MPP5", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MVK", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFV1", "NEFL", "NEFM", "NES", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NTHL1", "NUBP2", "NUBPL", "NUDT1", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHF8", "PHGDH", "PHIP", "PI4KA", "PIK3C2A", "PIN1", "PLEC", "PLOD1", "PLOD3", "PLRG1", "PLS1", "PLS3", "PNP", "PNPLA6", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2E", "POLR2F", "PPIB", "PPID", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RBBP7", "RCL1", "RDH13", "RDX", "RIDA", "RING1", "RIOK1", "RIOK2", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "RTN4IP1", "S100A10", "S100A11", "SART1", "SBDS", "SCD", "SCP2", "SDHB", "SDHC", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A2", "SLC27A4", "SLC2A1", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SPATA5", "SPATA5L1", "SPTBN1", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX10", "STX12", "STX17", "STX18", "STX4", "STX5", "STX6", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE2", "TAP1", "TAP2", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLE3", "TLN1", "TMBIM6", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM13", "TRIM21", "TRIM25", "TRIM28", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TST", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUBG1", "TUFM", "TXN2", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UHRF1", "USP10", "USP11", "USP14", "USP33", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ABCB1", "ABCB7", "ACTR1A", "ACTR2", "ALDH1B1", "ALDH3A2", "ALDH6A1", "AP1M1", "AP2M1", "CASK", "CDKAL1", "EIF4E", "FUCA2", "HADH", "HMGB1", "HMGB2", "HSP90AA1", "HSP90B1", "INA", "LAMP1", "LBR", "LMNB2", "MCL1", "MCM2", "MCM3", "MCM6", "MIF", "MPP2", "MPP5", "MPP6", "MPP7", "NEFL", "NEFM", "NUBP2", "OSBP", "OSBPL11", "OSBPL8", "PFN2", "PLOD3", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "RRP8", "STX10", "STX18", "TMX1", "TMX3", "TMX4", "TRIM13", "TSPAN3", "TSPAN6", "TUBB", "TUBB2A", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "VIM", "ZADH2"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Cytochrome b5-like heme/steroid binding domain [IPR001199]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Cytochrome b5-like heme/steroid binding domain [IPR001199]", "1": "GOLD domain [IPR009038]", "2": "Intermediate filament, rod domain [IPR039008]", "3": "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "4": "Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]", "5": "Tubulin/FtsZ, GTPase domain [IPR003008]", "6": "EF-hand domain [IPR002048]", "7": "Immunoglobulin-like domain [IPR007110]", "8": "CID domain [IPR006569]", "9": "SH2 domain [IPR000980]", "10": "RNA recognition motif domain [IPR000504]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:1e91595ffa2ffc248728da26e512822baec88488ee6e647f592451c1e092d5ca
+size 182361

interpro_domain/df_merge.tsv

@@ -0,0 +1,6 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Aminopeptidase N-like , N-terminal domain [IPR045357]	3	6	2.3019189181843065	0.0213397451280803	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0014043590152869	1.0	0.0758460972151271	0.0007102815399137	0.0003286021100258
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	3	6	2.3019189181843065	0.0213397451280803	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.0014043590152869	1.0	0.0758460972151271	0.0007102815399137	0.0003286021100258
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	5	6	2.1934801417141827	0.0282728038113517	2.813106796116505	6.104368932038835	1.6405397264547834	0.1100883340733615	1.2852875686886795	0.8042848477475721	1.100790504333474	0.1612592696854457	0.0050382705358123	0.0573151884822011	0.0058956460302812	0.032628233248221	0.0019884945269669
+Peptidase M16, N-terminal [IPR011765]	2	7	2.115168144752169	0.0344156189151507	2.6067961165048543	7.0	0.7914914082442276	0.4366893661235884	1.5075062759483802	0.0	0.8715475629418188	0.3304871916560691	0.0008979538364946	1.0	1.0	0.0112385866308786	0.0034377129995212
+Peptidase M16, C-terminal [IPR007863]	2	7	2.115168144752169	0.0344156189151507	2.6067961165048543	7.0	0.7914914082442276	0.4366893661235884	1.5075062759483802	0.0	0.8715475629418188	0.3304871916560691	0.0008979538364946	1.0	1.0	0.0112385866308786	0.0034377129995212

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3220,
+    "annotations_size": 2549,
+    "title": "Average number of proteins per term",
+    "value": 2.1439780306002354
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C288/C288_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,186 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.843332381192831	2.3019189181843065	0.0213397451280803	1.0	0.4496870741101658	6	Q9NZ08,Q9UIQ6,P55786	3
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.843332381192831	2.3019189181843065	0.0213397451280803	1.0	0.4496870741101658	6	Q9NZ08,Q9UIQ6,P55786	3
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.8186060983198604	2.1934801417141827	0.0282728038113517	1.0	0.4496870741101658	6	O15173,O43169,Q8WUJ1,Q9UMX5,O00264	5
+Peptidase M16, N-terminal [IPR011765]	0.7749507163238163	2.115168144752169	0.0344156189151507	1.0	0.4496870741101658	7	Q10713,P22695	2
+Peptidase M16, C-terminal [IPR007863]	0.7749507163238163	2.115168144752169	0.0344156189151507	1.0	0.4496870741101658	7	Q10713,P22695	2
+ERAP1-like C-terminal domain [IPR024571]	0.8777788596785823	1.9906485767592448	0.0465195357999814	1.0	0.4496870741101658	4	Q9NZ08,P55786	2
+GOLD domain [IPR009038]	0.7619788425637942	1.9400926804479093	0.0523684274072966	1.0	0.4552740288463645	6	Q9Y3B3,Q9BVK6,Q9H3P7,Q15363,P49755	5
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.861315780839336	1.9245937874769516	0.0542801972344906	1.0	0.4552740288463645	4	Q15629,Q96CP7	2
+Reticulon [IPR003388]	0.8550995024875598	1.899548842968218	0.0574923510853835	1.0	0.4557801861391966	4	Q9NQC3,O75298,O95197	3
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.7828926905132111	1.880923714687644	0.0599822967609045	1.0	0.4557801861391966	5	Q9HD20,P05023,P98194,P16615	4
+CBS domain [IPR000644]	0.7653511395368592	1.804428544124092	0.0711641516551075	1.0	0.4781837388700992	5	P51798,Q8NE01	2
+FAD dependent oxidoreductase [IPR006076]	0.8233966560537938	1.7709772870204394	0.0765644787791164	1.0	0.4781837388700992	4	Q96CU9	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.7446143160090188	1.7133162891185607	0.0866543672534532	1.0	0.4886769516129474	5	Q14914,Q8N4Q0	2
+Peptidase M28 [IPR007484]	0.931935155934204	1.654453068978288	0.098035491381951	1.0	0.5103419714106551	3	Q969V3	1
+LEM domain [IPR003887]	0.69212180807193	1.6183096224203657	0.105595888009256	1.0	0.5188524090797302	6	P50402,Q86XL3,P42167	3
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.7826492537313409	1.6038387414013755	0.1087496025698822	1.0	0.5210577762229882	4	P05023,P98194,P16615	3
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.7826492537313409	1.6038387414013755	0.1087496025698822	1.0	0.5210577762229882	4	P05023,P98194,P16615	3
+N-acetylgalactosaminyltransferase [IPR045885]	0.7819694196187692	1.6010342252601455	0.1093693389064629	1.0	0.522064503506693	4	Q8N4A0	1
+Post-SET domain [IPR003616]	0.7771415065138869	1.5811040897724284	0.1138542397820145	1.0	0.5275815439783621	4	Q03164,O96028	2
+Intermediate filament, rod domain [IPR039008]	0.6404541662383724	1.5779954314427866	0.1145666593601864	1.0	0.5275815439783621	8	P07196,P07197,Q03252,Q16352,P08670	5
+Glycosyltransferase 2-like [IPR001173]	0.6782066274547988	1.5531244342715458	0.1203934097075025	1.0	0.534639026732446	6	Q8N4A0	1
+Intermediate filament head, DNA-binding domain [IPR006821]	0.7646144278606937	1.5292855828054406	0.1261936621242054	1.0	0.5379057604591968	4	P07197,P08670,P07196	3
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.569186073838784	1.5167294075894129	0.1293350163652511	1.0	0.5429168963627622	11	Q9NWM8,Q9Y680,P26885,Q96AY3,P62942,Q5T1M5	6
+MCM OB domain [IPR033762]	0.6694200735605436	1.511801943827527	0.1305842547743065	1.0	0.5429168963627622	6	Q14566,P25205,P49736	3
+MCM, AAA-lid domain [IPR041562]	0.6694200735605436	1.511801943827527	0.1305842547743065	1.0	0.5429168963627622	6	Q14566,P25205,P49736	3
+MCM N-terminal domain [IPR027925]	0.6694200735605436	1.511801943827527	0.1305842547743065	1.0	0.5429168963627622	6	Q14566,P25205,P49736	3
+MCM domain [IPR001208]	0.6694200735605436	1.511801943827527	0.1305842547743065	1.0	0.5429168963627622	6	Q14566,P25205,P49736	3
+Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]	0.6273349937733487	1.5107813116900932	0.1308441776533413	1.0	0.5429168963627622	8	Q9BUF5,P68371,P04350,P07437,Q9BVA1,Q13885,Q13509	7
+Tubulin/FtsZ, GTPase domain [IPR003008]	0.6273349937733487	1.5107813116900932	0.1308441776533413	1.0	0.5429168963627622	8	Q9BUF5,P68371,P04350,P07437,Q9BVA1,Q13885,Q13509	7
+Alcohol dehydrogenase, N-terminal [IPR013154]	0.7590887538803055	1.5063835953313225	0.1319687294606235	1.0	0.5437990810208868	4	Q8N4Q0	1
+Ricin B, lectin domain [IPR000772]	0.6888470686125387	1.465040457614741	0.1429098800025148	1.0	0.5604265909637081	5	Q8N4A0	1
+SET domain [IPR001214]	0.6854202451771615	1.4496529232949404	0.1471553297789831	1.0	0.5694977031608193	5	Q03164,O96028	2
+Tim10-like [IPR004217]	0.873484612993471	1.4357782915314543	0.1510654388898209	1.0	0.5694977031608193	3	Q9Y5J9,P62072	2
+Zinc finger, CHHC-type [IPR012996]	0.8675784892757183	1.4136161237079756	0.1574746445226404	1.0	0.570229331226951	3	P31943,P55795	2
+MRH domain [IPR044865]	0.727637607459319	1.375605349090378	0.1689438497299833	1.0	0.5923492062747283	4	Q13438,P20645	2
+Tudor domain [IPR002999]	0.5996511714429553	1.3678652277774763	0.1713542657580919	1.0	0.5947269265585353	8	Q14739	1
+EXPERA domain [IPR033118]	0.9667495338719658	1.2824174401901325	0.1996962494875813	1.0	0.624423230575425	2	Q15125	1
+Phospholipase D/Transphosphatidylase [IPR001736]	0.9608452454940956	1.2605001782324678	0.2074889836363862	1.0	0.6364493613587828	2	Q8IV08	1
+Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]	0.824370531551129	1.2514965264640314	0.2107533801631245	1.0	0.6369620030257631	3	O75431,Q13505	2
+Metaxin, glutathione S-transferase domain [IPR033468]	0.824370531551129	1.2514965264640314	0.2107533801631245	1.0	0.6369620030257631	3	O75431,Q13505	2
+Endoplasmic reticulum vesicle transporter, N-terminal [IPR039542]	0.8238945755225329	1.2497129765507713	0.211404415284345	1.0	0.6369620030257631	3	Q9Y282	1
+Endoplasmic reticulum vesicle transporter, C-terminal [IPR012936]	0.8238945755225329	1.2497129765507713	0.211404415284345	1.0	0.6369620030257631	3	Q9Y282	1
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.8078955548647815	1.1898256210632183	0.2341149372288562	1.0	0.6697631593674013	3	O43823,Q5BKZ1	2
+Prenylcysteine lyase [IPR010795]	0.935985083903041	1.1685791392323468	0.2425732370467184	1.0	0.6717784684390785	2	Q9UHG3	1
+Phospholipid/glycerol acyltransferase [IPR002123]	0.5717700117700497	1.12932668300381	0.2587600487441643	1.0	0.6928354666479779	7	Q8NF37,O15228,Q9NUQ2	3
+GMP phosphodiesterase, delta subunit [IPR008015]	0.9220012430080702	1.1171980630200629	0.2639096486310279	1.0	0.7001892293893385	2	A6NIH7	1
+BRICHOS domain [IPR007084]	0.9123679303915412	1.0819714472087163	0.279265215440386	1.0	0.7147058575878956	2	Q9Y287	1
+Syntaxin 6, N-terminal [IPR015260]	0.910192666252325	1.0740383231016484	0.2828055057239798	1.0	0.7157537846244383	2	O60499	1
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.906774394033561	1.0615888152566837	0.2884223935068983	1.0	0.716334141022957	2	Q9BTY2	1
+Target SNARE coiled-coil homology domain [IPR000727]	0.5074866551283004	1.0491638691750729	0.2941027045939137	1.0	0.7217885424930294	10	O60499	1
+Protein kinase, C-terminal [IPR017892]	0.592904183775347	1.0316996245184724	0.3022128533809449	1.0	0.7242510560785628	5	P31751,Q15418	2
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.897451833436915	1.0277464482562224	0.3040691126066153	1.0	0.7242510560785628	2	O15254	1
+Ras-associating (RA) domain [IPR000159]	0.6433126659937214	1.024290031029358	0.3056983051640949	1.0	0.7242510560785628	4	Q9Y4G8	1
+Zinc finger, RanBP2-type [IPR001876]	0.5293092939528569	1.0006162806793513	0.3170123559988638	1.0	0.737958443325209	8	Q92804,P98175,P35637	3
+ABC transporter type 1, transmembrane domain [IPR011527]	0.5308630612858494	0.9252014890696144	0.3548611090901055	1.0	0.7785428150976204	7	O75027,P08183	2
+Ribosomal S6 kinase, N-terminal catalytic domain [IPR041906]	0.8564325668116795	0.8811951047550342	0.3782122283909155	1.0	0.7960722062917872	2	Q15418	1
+NOPS [IPR012975]	0.7221013366490501	0.8736217257231883	0.3823242906672324	1.0	0.7960722062917872	3	P23246,Q15233	2
+Fatty acid hydroxylase [IPR006694]	0.85425730267245	0.8735512055715008	0.3823627088362555	1.0	0.7960722062917872	2	Q15800	1
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.8440024860161601	0.8377199641222485	0.4021879982907463	1.0	0.8135432990000262	2	Q9NVI7	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.8368551895587333	0.8129579505255952	0.4162421672364691	1.0	0.8269690446498518	2	O43390	1
+FCP1 homology domain [IPR004274]	0.6885296860428982	0.754288291426621	0.4506761313766234	1.0	0.8530575417719954	3	Q05D32,Q8WVY7	2
+GYF domain [IPR003169]	0.811995027967684	0.7283547316849925	0.4663964665101874	1.0	0.8714664252945514	2	O95400	1
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.8107520198881315	0.7241926310338275	0.4689474819388213	1.0	0.8739315202806441	2	Q14011	1
+LEM-like domain [IPR013146]	0.8057799875699216	0.7076144687102374	0.4791847052848232	1.0	0.8800013067514514	2	P42167	1
+CARG-binding factor, N-terminal [IPR012956]	0.8014294592914881	0.6932032699201032	0.4881819964018834	1.0	0.8817341175348952	2	Q14103	1
+Choline/carnitine acyltransferase domain [IPR039551]	0.7952144188937018	0.6727752050775152	0.5010903143306771	1.0	0.8859236988533888	2	P23786	1
+EF-hand domain [IPR002048]	0.3735225351754409	0.6230616551965564	0.5332440064274988	1.0	0.9048822049986868	47	Q9NWM8,O95202,Q02818,Q14257,Q8NF37,Q9Y680,O43852,P41208,Q6NUK1,P80303,Q8IYU8,O75071,P14649,O75340	14
+Acyltransferase, C-terminal domain [IPR032098]	0.7762585456805224	0.6117134733216523	0.5407273460682727	1.0	0.9048822049986868	2	Q9NUQ2	1
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.7719080174021171	0.5979823540065278	0.5498517073989238	1.0	0.906008694172174	2	P10321	1
+MHC class I-like antigen recognition-like [IPR011161]	0.7719080174021171	0.5979823540065278	0.5498517073989238	1.0	0.906008694172174	2	P10321	1
+MHC class I, alpha chain, C-terminal [IPR010579]	0.7719080174021171	0.5979823540065278	0.5498517073989238	1.0	0.906008694172174	2	P10321	1
+Immunoglobulin C1-set [IPR003597]	0.7719080174021171	0.5979823540065278	0.5498517073989238	1.0	0.906008694172174	2	P10321	1
+Phox homology [IPR001683]	0.40873925945016	0.5873730117479483	0.5569532153222849	1.0	0.9063341653562482	12	Q9Y2I1,Q96S38	2
+B-box-type zinc finger [IPR000315]	0.4871044451944176	0.5680956022511214	0.5699700537724857	1.0	0.9063341653562482	5	O60858	1
+Histone-binding protein RBBP4, N-terminal [IPR022052]	0.759788688626476	0.5603339632989133	0.5752516654485693	1.0	0.9071421057366008	2	Q9BQ67	1
+Acyl-CoA oxidase/dehydrogenase, central domain [IPR006091]	0.4322904204317815	0.5582567746132707	0.5766690570116579	1.0	0.907363843409084	9	Q15067,O15254	2
+TRAM domain [IPR002792]	0.7563704164076819	0.5498824401949363	0.5824000090088253	1.0	0.9097996921656076	2	Q5VV42	1
+Methylthiotransferase, N-terminal [IPR013848]	0.7563704164076819	0.5498824401949363	0.5824000090088253	1.0	0.9097996921656076	2	Q5VV42	1
+Cyclic nucleotide-binding domain [IPR000595]	0.519675753615847	0.5342891633495174	0.5931414885010615	1.0	0.9175250000251302	4	Q9Y4G8	1
+Fibronectin type II domain [IPR000562]	0.7470478558110677	0.5217718657587217	0.6018291805933988	1.0	0.9219126089739024	2	Q9UBV2	1
+Tim44-like domain [IPR007379]	0.7433188315724066	0.510694252265409	0.6095651660696935	1.0	0.9249250745686628	2	Q9BRJ2	1
+ABC transporter-like, ATP-binding domain [IPR003439]	0.4111541577629098	0.5070595621835099	0.6121130271979989	1.0	0.9249250745686628	10	O75027,P08183	2
+DZF domain [IPR006561]	0.5111940298507414	0.5034700866489286	0.61463380644153	1.0	0.9264941292841276	4	Q12905,Q12906,Q96SI9	3
+Ovarian carcinoma immunoreactive antigen domain [IPR009764]	0.7402113113735013	0.501537933104526	0.6159925882891271	1.0	0.9279935623811968	2	Q9NX40	1
+Major facilitator superfamily domain [IPR020846]	0.4690520886340404	0.4943485282050239	0.6210600583827752	1.0	0.9317605568235366	5	P11166,P53985,Q9H2V7	3
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.6083484995079672	0.4892438090155521	0.6246690973816864	1.0	0.931951061262357	3	P13674	1
+Far upstream element-binding protein, C-terminal [IPR015096]	0.726538222498452	0.4620919095000848	0.6440154117906569	1.0	0.9354220274443148	2	Q92945	1
+OCRE domain [IPR041591]	0.7246737103791066	0.4568228005982412	0.6477984160199162	1.0	0.9354220274443148	2	P98175	1
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.4578736467398068	0.449993317599216	0.6527152589543979	1.0	0.9354220274443148	5	P13674,Q32P28	2
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.4578736467398068	0.449993317599216	0.6527152589543979	1.0	0.9354220274443148	5	P13674,Q32P28	2
+Immunoglobulin-like domain [IPR007110]	0.3805603871329958	0.4468559750229272	0.6549790528400818	1.0	0.9354220274443148	13	P35613,Q08722,Q9Y639,P10586,P10321	5
+SUN coiled coil domain 2 [IPR040994]	0.7125543816034565	0.4232475545050143	0.672114654209935	1.0	0.9375136458569808	2	Q9UH99	1
+Alcohol dehydrogenase-like, C-terminal [IPR013149]	0.4488391327802891	0.4149801312858506	0.6781564481137632	1.0	0.9394791984511248	5	Q14914	1
+Lamin tail domain [IPR001322]	0.5781507724258742	0.4001261167112441	0.6890636290846668	1.0	0.9394791984511248	3	Q03252	1
+EB1, C-terminal [IPR004953]	0.7026103169670559	0.3966053688864076	0.6916584928013907	1.0	0.9394791984511248	2	Q15555	1
+ELMO domain [IPR006816]	0.6911124922312067	0.3668718171012023	0.713714634543315	1.0	0.9424143192244904	2	Q96JJ3	1
+Ubiquitin system component CUE [IPR003892]	0.4699777972872611	0.3624515918652466	0.7170145917981467	1.0	0.9430333187227836	4	Q9Y679	1
+Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]	0.6855189558732206	0.3528381494863346	0.7242097816687387	1.0	0.946326019301995	2	Q9Y305	1
+RBM1CTR [IPR012604]	0.6839651957737801	0.3489912300083848	0.7270958935871055	1.0	0.946326019301995	2	P38159	1
+Rab-GTPase-TBC domain [IPR000195]	0.4614427860696441	0.3353596210860643	0.7373538237605481	1.0	0.9476108388678204	4	Q8TC07,Q9Y3P9,Q66K14	3
+DDHD domain [IPR004177]	0.6774394033561295	0.3330819175301343	0.7390724485278115	1.0	0.9476108388678204	2	O94830	1
+Zinc finger, CCHC-type [IPR001878]	0.4100145632846486	0.3204878234881682	0.7485985594432825	1.0	0.9511726537674616	6	Q9NUD5	1
+Rhodanese-like domain [IPR001763]	0.4223410057308281	0.3172773739083063	0.7510331441468958	1.0	0.9511726537674616	5	P25325	1
+L27 domain, C-terminal [IPR014775]	0.4211634558019329	0.3131274510075179	0.7541838341473339	1.0	0.9511726537674616	5	Q14168,Q8N3R9	2
+L27 domain [IPR004172]	0.4211634558019329	0.3131274510075179	0.7541838341473339	1.0	0.9511726537674616	5	Q14168,Q8N3R9	2
+Exportin-2, central domain [IPR013713]	0.5414982903326164	0.3026490379765985	0.7621573390628611	1.0	0.9527181262595388	3	P55060,O15397	2
+Glycogen synthase kinase 3, catalytic domain [IPR039192]	0.6643878185208286	0.3024929557369801	0.762276302606208	1.0	0.9527181262595388	2	P49840	1
+1-acyl-sn-glycerol-3-phosphate acyltransferase [IPR004552]	0.6619018023617238	0.2968567177211486	0.7665759016090266	1.0	0.9552982690138594	2	O15120	1
+4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]	0.5363187322946142	0.2899386369178418	0.771863182565967	1.0	0.9573972614540196	3	Q16134	1
+Proteasome activator PA28, N-terminal domain [IPR003185]	0.5304755569460793	0.275937763264859	0.7825958685762759	1.0	0.964470983418943	3	P61289	1
+Proteasome activator PA28, C-terminal domain [IPR003186]	0.5304755569460793	0.275937763264859	0.7825958685762759	1.0	0.964470983418943	3	P61289	1
+3-hydroxyacyl-CoA dehydrogenase, NAD binding [IPR006176]	0.6522684897451922	0.2756049852373609	0.7828514802520401	1.0	0.964470983418943	2	Q16836	1
+3-hydroxyacyl-CoA dehydrogenase, C-terminal [IPR006108]	0.6522684897451922	0.2756049852373609	0.7828514802520401	1.0	0.964470983418943	2	Q16836	1
+STAT transcription factor, protein interaction [IPR013799]	0.6504039776258617	0.2716011224178862	0.7859287363230238	1.0	0.964470983418943	2	P40763	1
+STAT transcription factor, all-alpha domain [IPR013800]	0.6504039776258617	0.2716011224178862	0.7859287363230238	1.0	0.964470983418943	2	P40763	1
+STAT transcription factor, DNA-binding [IPR013801]	0.6504039776258617	0.2716011224178862	0.7859287363230238	1.0	0.964470983418943	2	P40763	1
+BSD domain [IPR005607]	0.648850217526423	0.2682919460532742	0.7884746051679421	1.0	0.964470983418943	2	Q96A49	1
+BAG domain [IPR003103]	0.4340796019900411	0.2542980965057716	0.7992652702482599	1.0	0.964470983418943	4	Q9UL15,O95817,O95429	3
+Fzo/mitofusin HR2 domain [IPR006884]	0.6357986326911085	0.2414886085901738	0.8091764443059013	1.0	0.964470983418943	2	Q8IWA4	1
+CAP Gly-rich domain [IPR000938]	0.5144544606776591	0.239446292385386	0.8107595376480747	1.0	0.964470983418943	3	Q14203,Q99426	2
+Diacylglycerol kinase, catalytic domain [IPR001206]	0.6314481044126884	0.2329534068142933	0.8157975863976583	1.0	0.964470983418943	2	Q53H12	1
+Major sperm protein (MSP) domain [IPR000535]	0.505750699409397	0.220823354262834	0.8252299783588524	1.0	0.964470983418943	3	Q9P0L0,Q8NHP6	2
+GRAM domain [IPR004182]	0.5013544559301417	0.2117466878051619	0.8323046622655037	1.0	0.9667630433566512	3	Q66K14	1
+Glutamine amidotransferase type 2 domain [IPR017932]	0.4973577867578548	0.2036893979068737	0.8385962277567673	1.0	0.9667941133206692	3	Q06210,Q06203	2
+RNA recognition motif domain, eukaryote [IPR003954]	0.336098657031629	0.2003827840493011	0.8411812227765116	1.0	0.9672515559043248	13	Q9UHX1,P38159,Q14011,Q14498	4
+CID domain [IPR006569]	0.3752333540759134	0.1940567490691666	0.8461314470387411	1.0	0.9688424910282756	6	O15042,Q5VT52,O95104,Q8IWX8,Q9NQG5	5
+Sorting nexin Vps5-like, C-terminal [IPR015404]	0.4026741293532272	0.1735183963518598	0.8622439690075487	1.0	0.9712151467080168	4	O60749,Q9UNH7,Q9Y5X3	3
+AGC-kinase, C-terminal [IPR000961]	0.3628902641543295	0.1699316268439357	0.8650639082124953	1.0	0.9718148532541432	7	P31751,Q15418	2
+NOT2/NOT3/NOT5, C-terminal [IPR007282]	0.5929148539465618	0.1662546544089056	0.8679565498720567	1.0	0.9743706528194196	2	Q9NZN8	1
+PUA domain [IPR002478]	0.447932856698798	0.1197055552759923	0.9047163995335123	1.0	0.983250755294118	3	O60832,Q9Y221	2
+SH2 domain [IPR000980]	0.3379009654313324	0.1195152036768953	0.904867195575437	1.0	0.983250755294118	9	Q06124,P42224,P46108,P46109,Q7KZ85,P07948,P40763,P62993	8
+Syntaxin, N-terminal domain [IPR006011]	0.4435809760646617	0.1137049466609317	0.909471691088686	1.0	0.983250755294118	3	Q86Y82,Q12846	2
+RNA recognition motif domain [IPR000504]	0.2780570210782648	0.1136234796169271	0.9095362738447288	1.0	0.983250755294118	117	Q99729,Q01085,P35637,Q15233,P51991,O60506,Q07955,Q01844,Q8WUA2,P22626,P62995,P26368,Q14011,Q92804,P52597,Q8WVV9,Q96PK6,Q9GZT3,P55795,Q13242,P98175,O15047,O14979,Q13151,P31943,Q8IZ69,Q16630,Q14498,P31942,Q9UHX1,Q14103,P98179,P23246,Q9BWF3,P84103,O43390,P38159,Q93062	38
+Immunoglobulin subtype 2 [IPR003598]	0.3354379806226274	0.1100632285198403	0.9123592303253882	1.0	0.983250755294118	9	Q9Y639,P10586	2
+DNA mismatch repair protein MutS, clamp [IPR007861]	0.548166563082673	0.108754837191993	0.9133969459653232	1.0	0.983250755294118	2	P43246	1
+EF-hand, Ca insensitive [IPR014837]	0.3700248756218838	0.105049636564315	0.9163364222927096	1.0	0.983250755294118	4	Q13813,O43707,P12814	3
+SKP1 component, POZ domain [IPR016073]	0.5388440024860264	0.099347661625252	0.920862237061054	1.0	0.9840285752630332	2	P63208	1
+Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]	0.5323182100683792	0.0932582217996978	0.9256984215599656	1.0	0.9840285752630332	2	O94979	1
+F-BAR domain [IPR031160]	0.526103169670617	0.0878266881438973	0.9300144256515864	1.0	0.9856003648969284	2	Q9UKS6	1
+FCH domain [IPR001060]	0.526103169670617	0.0878266881438973	0.9300144256515864	1.0	0.9856003648969284	2	Q9UKS6	1
+Peptidase M41 [IPR000642]	0.5180236171535259	0.0812851277443105	0.935215201190362	1.0	0.9891549991013414	2	Q9Y4W6	1
+Armadillo repeat-containing domain [IPR006911]	0.5031075201988952	0.0706733820956373	0.9436577058611764	1.0	0.9943710178752124	2	Q9UH62	1
+Rpn11/EIF3F, C-terminal [IPR024969]	0.3470149253731289	0.06673222107207	0.9467948827693264	1.0	0.9972645273466996	4	O00487,Q7L5N1,O00303	3
+Glutathione S-transferase, N-terminal [IPR004045]	0.3274312436507892	0.0660443820818814	0.94734249077293	1.0	0.997429165212804	8	P78417	1
+Death domain [IPR000488]	0.3972645321728421	0.0631467763933716	0.949649626420862	1.0	0.9994454573686116	3	Q13546,Q12955	2
+ZU5 domain [IPR000906]	0.4881914232442608	0.0618210765620323	0.9507053189195744	1.0	0.999730964490922	2	Q12955	1
+3'-5' exonuclease domain [IPR002562]	0.4847731510254974	0.0600218606331733	0.9521382238093392	1.0	1.0	2	Q01780	1
+Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain [IPR008333]	0.4841516469857168	0.0597034893841944	0.95239179256828	1.0	1.0	2	P00387	1
+Zinc finger, TFIIB-type [IPR013137]	0.480422622747059	0.0578486955746629	0.9538691496354532	1.0	1.0	2	P29083	1
+Peptidase M20, dimerisation domain [IPR011650]	0.4676817899316511	0.0521951611966051	0.9583731884857724	1.0	1.0	2	Q8IYS1	1
+Potassium channel tetramerisation-type BTB domain [IPR003131]	0.4499689247980265	0.04592088143652	0.9633733107524104	1.0	1.0	2	Q96CX2	1
+p21 activated kinase binding domain [IPR033923]	0.4425108763207075	0.0437649812142079	0.965091741267005	1.0	1.0	2	Q13153	1
+CRIB domain [IPR000095]	0.4425108763207075	0.0437649812142079	0.965091741267005	1.0	1.0	2	Q13153	1
+Arf GTPase activating protein [IPR001164]	0.4390926041019443	0.042863445634055	0.9658103881125712	1.0	1.0	2	Q8N6T3	1
+Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain [IPR044861]	0.4353635798632783	0.0419385785637804	0.9665476621919504	1.0	1.0	2	O60568	1
+Lens epithelium-derived growth factor, integrase-binding domain [IPR021567]	0.4344313238036226	0.041716614398414	0.9667246091159094	1.0	1.0	2	Q7Z4V5	1
+Exosome complex component, N-terminal domain [IPR025721]	0.4139216904910036	0.0376765339721669	0.9699455858869308	1.0	1.0	2	Q9Y3B2	1
+Myotubularin-like phosphatase domain [IPR010569]	0.4095711622125674	0.037004365279324	0.9704815251363456	1.0	1.0	2	Q9C0I1	1
+MIRO domain [IPR020860]	0.4070851460534609	0.0366457239166594	0.9707674855820212	1.0	1.0	2	Q8IXI1	1
+EF hand associated, type-1 [IPR013566]	0.4070851460534609	0.0366457239166594	0.9707674855820212	1.0	1.0	2	Q8IXI1	1
+EF hand associated, type-2 [IPR013567]	0.4070851460534609	0.0366457239166594	0.9707674855820212	1.0	1.0	2	Q8IXI1	1
+NECAP, PHear domain [IPR012466]	0.4067743940335704	0.0366021498148294	0.9708022293761572	1.0	1.0	2	Q9NVZ3	1
+CRK, C-terminal SH3 domain [IPR035458]	0.3993163455562572	0.035635872885903	0.9715727040512304	1.0	1.0	2	P46108	1
+CRK, N-terminal SH3 domain [IPR035457]	0.3993163455562572	0.035635872885903	0.9715727040512304	1.0	1.0	2	P46108	1
+Thioesterase domain [IPR006683]	0.3850217526414036	0.0341641274285969	0.9727462719967672	1.0	1.0	2	O00154	1
+Band 7 domain [IPR001107]	0.3171694106757965	0.0339769487103194	0.972895532350003	1.0	1.0	8	Q99623,O75955,Q9UJZ1,P27105	4
+CTLH/CRA C-terminal to LisH motif domain [IPR024964]	0.37228091982599	0.0331997539479972	0.9735152943366696	1.0	1.0	2	Q96S59	1
+CRA domain [IPR013144]	0.37228091982599	0.0331997539479972	0.9735152943366696	1.0	1.0	2	Q96S59	1
+Thioredoxin-like fold [IPR012336]	0.3707271597265491	0.0331009632419544	0.9735940746161976	1.0	1.0	2	Q6DKJ4	1
+rRNA-processing arch domain [IPR025696]	0.3645121193287854	0.0327416641065847	0.9738805985362408	1.0	1.0	2	Q15477	1
+ATP-dependent RNA helicase Ski2, C-terminal [IPR012961]	0.3645121193287854	0.0327416641065847	0.9738805985362408	1.0	1.0	2	Q15477	1
+NIPSNAP [IPR012577]	0.3620261031696811	0.0326129631007836	0.9739832322705272	1.0	1.0	2	O75323	1
+S1-like RNA binding domain [IPR025223]	0.3433809819763968	0.0318751449708919	0.9745716200050024	1.0	1.0	2	Q8N163	1
+LAIKA domain [IPR045353]	0.3433809819763968	0.0318751449708919	0.9745716200050024	1.0	1.0	2	Q8N163	1
+BURAN domain [IPR045354]	0.3433809819763968	0.0318751449708919	0.9745716200050024	1.0	1.0	2	Q8N163	1
+DBC1/CARP1 catalytically inactive NUDIX hydrolase domain [IPR025954]	0.3433809819763968	0.0318751449708919	0.9745716200050024	1.0	1.0	2	Q8N163	1
+Copine, C-terminal [IPR010734]	0.3380981976382997	0.0317264028292399	0.9746902390690012	1.0	1.0	2	Q99829	1
+Copine, C2B domain [IPR037768]	0.3380981976382997	0.0317264028292399	0.9746902390690012	1.0	1.0	2	Q99829	1
+PTBP1, RNA recognition motif 2-like [IPR021790]	0.3192774381986643	0.0312111369124987	0.9751011582705056	1.0	1.0	4	Q8WVV9	1
+Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]	0.270043505282798	0.0310055746931871	0.9752650938494238	1.0	1.0	2	Q9NVE7	1
+Nuclear transport factor 2, eukaryote [IPR018222]	0.3187189054726297	0.030609970386716	0.9755805906581724	1.0	1.0	4	Q9UBU9,Q9UN86,P61970	3
+Nuclear transport factor 2 domain [IPR002075]	0.3187189054726297	0.030609970386716	0.9755805906581724	1.0	1.0	4	Q9UBU9,Q9UN86,P61970	3
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.3058750388560843	0.0200438879359619	0.984008362077864	1.0	1.0	3	Q9BUJ2,Q1KMD3	2
+Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]	0.3061110469597474	0.0181663572065778	0.9855061412653972	1.0	1.0	4	P10586	1
+Glutathione S-transferase, C-terminal-like [IPR010987]	0.2964497600373406	0.0093440076578642	0.9925446690420106	1.0	1.0	12	Q9Y696,P78417	2