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429fc5c verified
Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
Transport of small molecules 0.4317436649343035 3.2361421483878936 0.001211570334777 0.807473665345089 0.1372103404134992 134 Q9BUN8,Q8WTV0,P35670,Q8N4V1,Q9UL46,Q9C0H2,P21796,P08183,Q9Y277,Q99808,P45880,P10644,Q9Y487,Q99797,P33527,Q93050,Q99436,O00487,Q06323,P28074,P40855,P35611,P30519,Q96TA2,Q70HW3,P63218,P28072,P53985,Q9UI12,O15118,Q10713,P60900,P49721,P02786,Q9Y5K8,Q9UJZ1,Q9HD20,Q9GZP9,Q8N8Q9,P49720,O75832,O00231,P09496,P28070,P35610 45
Cilium assembly 0.5294151358291964 2.946401990412163 0.0032149428497429 0.9874262709439194 0.1646444560974633 52 Q9Y496,P49368,A6NIH7,O75935,P62258,P07437,Q96A65,Q9H6D7,Q96KP1,O75695,P68371,O43924,Q13885,Q15154,Q10713,O94927,Q92973,O95684,P53350 19
Mitochondrial protein import 0.605870918091112 2.9085939036313917 0.0036305812447696 0.992866392561298 0.1646444560974633 35 O60830,Q99595,Q9UJS0,Q15388,Q9Y584,Q9NX63,Q9NS69,Q5JRX3,Q8N4H5,P21796,Q10713 11
Protein localization 0.4745445554607688 2.8225474270967936 0.0047643774546586 0.9984818492504376 0.1660202297661815 67 O43681,O60830,Q99595,Q9UJS0,Q15388,P50542,Q9Y584,Q9NS69,Q9NX63,P46379,O15254,Q8NBU5,Q5JRX3,Q8N4H5,P21796,Q10713,Q13011 17
Cargo recognition for clathrin mediated endocytosis 0.5736920433605102 2.4060789168678136 0.01612478102882 0.999999999745616 0.365226290302775 26 Q14108,P02786,P11717,Q7L5N1,Q9BT78,O43493,P20645,Q99627,P62993,P09496,Q92783,Q8NC96,Q9NVZ3 13
Kinesins 0.6148922785848825 2.396957441726844 0.0165318437213346 0.9999999998550392 0.3683077970048162 19 P33176,O00139,Q9NSK0,Q12756,P04350,P52732,Q9Y496,Q13885,Q9H0H5,Q9H0B6,Q14807,P68371,Q07866,O95235 14
Cargo trafficking to the periciliary membrane 0.6029619326965155 2.3545331227893667 0.0185459907624223 0.9999999999910616 0.400063515017968 20 Q96A65,P49368,A6NIH7,Q96KP1,Q10713,O43924 6
Pink1 prkn mediated mitophagy 0.8067322498218175 2.2683207240445524 0.0233096656919582 0.999999999999988 0.4202031867538676 7 Q9NS69,Q15388,P21796 3
Mitophagy 0.7399147720423125 2.2649862633590496 0.0235135224877209 0.999999999999991 0.4202031867538676 10 Q9NS69,Q15388,P21796 3
Sphingolipid metabolism 0.5599101574938946 2.260939118701579 0.023763027318773 0.9999999999999936 0.4202031867538676 25 O43681,Q96G23,P07602,O15269,P06865,P06280 6
Ras processing 0.8383498359546724 2.24184065219088 0.0249716728276834 0.9999999999999988 0.4202031867538676 6 O60725,P49356,P49354 3
Autophagy 0.4902805736641941 2.195049787093718 0.0281600265571153 1.0 0.4252164010124419 43 O60664,Q15388,P50542,Q9NS69,P49815,Q13885,Q9Y2Q5,Q9Y6G9,Q9Y4P1,Q8N4H5,P21796,P08670,P68371 13
Striated muscle contraction 0.9031791907514372 2.1820958009083196 0.0291024630554055 1.0 0.4346181021131441 5 Q9NYL9,P08670,P35609,P67936 4
Selective autophagy 0.5228448604733449 2.156864565888362 0.0310162185551492 1.0 0.4484153299622109 30 O60664,Q15388,P50542,Q9NS69,Q13885,Q9Y6G9,Q8N4H5,P21796,P08670,P68371 10
Mitochondrial calcium ion transport 0.5911093122323122 2.019272523015623 0.0434589021162454 1.0 0.5538578442236497 15 P45880,Q96TA2,Q9UJZ1,P21796,Q10713 5
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.7759760364475851 1.9730814654275148 0.0484862815866362 1.0 0.5883290774664167 6 Q9UIV1,Q9UKZ1,Q92600 3
Glycerophospholipid biosynthesis 0.5144268894177431 1.89142167399228 0.0585680775819779 1.0 0.617007887084558 24 O95674,Q9NPH0,P40939,Q8IV08,P35790,Q8NCC3 6
Aurka activation by tpx2 0.5079024712632487 1.882817392300592 0.0597251192163099 1.0 0.624357207807425 25 Q9H6D7,P62258,Q15154,O94927,O95684,O75935,P68371,P53350 8
Organelle biogenesis and maintenance 0.3843715706673242 1.8593611823518332 0.0629759600952299 1.0 0.6386890281299817 83 P49368,Q9Y496,A6NIH7,O75947,P00846,O75935,Q13505,P62258,Q96A65,Q9H6D7,Q96KP1,O75695,P68371,O43924,Q9NX63,Q15154,Q10713,Q92973,O94927,O95684,P53350 21
G alpha 12 13 signalling events 0.6952136887543865 1.8499637293858204 0.0643187774411262 1.0 0.6427148422241953 8 Q92974,Q14155,P63218 3
Gpcr ligand binding 0.6754614515900477 1.8443992158139888 0.0651249815234795 1.0 0.6460208021197716 9 P07602,P42892 2
Sphingolipid de novo biosynthesis 0.6527490474752681 1.8266362926918391 0.0677544727933068 1.0 0.6644673328668951 10 Q96G23 1
Abc family proteins mediated transport 0.4183365773246 1.8240749701425436 0.0681407389740011 1.0 0.6644673328668951 52 P28074,P40855,O00231,O75832,Q9GZP9,P28072,P33527,Q9UL46,P49720,Q99436,P08183,P60900,P28070,Q06323,P49721 15
Class a 1 rhodopsin like receptors 0.735305457018979 1.7937477839299507 0.0728534346545963 1.0 0.6652514858193948 6 P42892 1
Peptide ligand binding receptors 0.735305457018979 1.7937477839299507 0.0728534346545963 1.0 0.6652514858193948 6 P42892 1
Initiation of nuclear envelope ne reformation 0.5460569746576162 1.7845682188044905 0.0743313802762191 1.0 0.6652514858193948 16 P30153,Q9Y2U8,Q14739,P20700,P50402,P02545,P06493,P42167,O75531,P63151,Q14974,Q86XL3,P42166 13
Recruitment of mitotic centrosome proteins and complexes 0.4887860848348382 1.780176438766459 0.075047090047277 1.0 0.6652514858193948 26 O75935,Q9H6D7,Q15154,O94927,O95684,P62258,P68371,P53350 8
Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.6434518802785667 1.7787060140485702 0.0752879726923971 1.0 0.6652514858193948 10 P46379 1
P75 ntr receptor mediated signalling 0.5521113701822322 1.777943599488204 0.0754131185090645 1.0 0.6652514858193948 15 P42574,Q92974,Q14155,P42575,P62258,Q14344,Q9NQC3,Q92769 8
E2f mediated regulation of dna replication 0.6430657174162213 1.7767106070001324 0.0756158662151431 1.0 0.6652514858193948 10 P30154,Q9UBD5,Q9Y619,P49642,Q14181,P06493 6
Iron uptake and transport 0.5353310548388622 1.7633293182989729 0.077844963263058 1.0 0.66956522199048 17 Q93050,Q9Y487 2
Anchoring of the basal body to the plasma membrane 0.482834468583859 1.7348898096321437 0.0827603244615757 1.0 0.684844134304833 26 Q9H6D7,P62258,Q15154,O94927,O95684,O75935,P68371,P53350 8
Purine salvage 0.7924235073897393 1.732700889605135 0.0831488463284013 1.0 0.684844134304833 5 P00813 1
Recruitment of numa to mitotic centrosomes 0.4651301460529257 1.7000861826775735 0.0891147159019516 1.0 0.7167477342164504 30 O75935,Q9H6D7,Q15154,O94927,O95684,P62258,P68371,P07437,P53350 9
Transferrin endocytosis and recycling 0.6089470368790544 1.6976518103743377 0.0895734980161802 1.0 0.7167477342164504 11 P02786,Q9Y487,Q9Y5K8,Q93050,Q9UI12 5
Metabolism of porphyrins 0.6457307345310073 1.696083044966011 0.0898701541090463 1.0 0.7167477342164504 9 P33527,P22830 2
Early phase of hiv life cycle 0.6597686844668976 1.678982030305803 0.0931555459544135 1.0 0.7189675252140447 8 O75475 1
Synthesis of pg 0.9307109346806192 1.6727591412793428 0.0943747213536037 1.0 0.7189675252140447 2 Q8IV08 1
Nucleotide salvage 0.6763940991966231 1.6720381751288091 0.0945167945281433 1.0 0.7189675252140447 7 P00813 1
Signaling by insulin receptor 0.5336022738806189 1.661518128267348 0.0966094311348073 1.0 0.7219993589061975 15 Q9Y487,P31751,Q9Y5K8,Q93050,Q9UI12,P62993 6
Glycosphingolipid metabolism 0.533132121467762 1.658546148081872 0.0972072810128459 1.0 0.7219993589061975 15 O43681,P07602,Q9NZD2,Q9NXE4,P06865,P06280,P10619 7
Cell death signalling via nrage nrif and nade 0.6181390028168964 1.6471626088276328 0.0995246270636691 1.0 0.7311025307001426 10 Q92974,Q14155,P42575,P62258,Q14344,P42574 6
Signaling by hippo 0.7000361402240614 1.6358447305932662 0.1018720876978012 1.0 0.7355889251986396 6 Q13043,Q07157,P62258,Q4VCS5,P42574 5
Synthesis of pe 0.9191627571273888 1.6253287159029857 0.1040925358891873 1.0 0.7399460599152184 2 P35790 1
Fgfr1 mutant receptor activation 0.6660514479400123 1.623231901405252 0.1045398406944237 1.0 0.7399460599152184 7 O95429,O95684 2
Negative regulation of nmda receptor mediated neuronal transmission 0.7628305588847079 1.6096161264806284 0.1074816854445255 1.0 0.7452429108117866 5 P35609 1
Endosomal vacuolar pathway 0.8687906205855848 1.5919973947172372 0.1113852899402143 1.0 0.7683888783185344 4 P10321,Q9UIQ6 2
Visual phototransduction 0.6840702411289667 1.5637154590729991 0.1178844056487578 1.0 0.7913856894920174 6 P49354,P09455 2
Ion channel transport 0.4785686748836112 1.5619132141656982 0.118308435075165 1.0 0.7913856894920174 22 P35670,Q93050,Q9C0H2,Q9Y487 4
Rhoa gtpase cycle 0.4235860928111382 1.5337882994703762 0.1250817424019745 1.0 0.8172408073282856 41 Q96HY6,O15173,P30519,Q92974,Q14155,Q9H0H5,O75116,Q8NBN3,Q86UP2,P41440 10
Insulin receptor recycling 0.595837205045974 1.5301019183108455 0.1259915035059078 1.0 0.8192461878685585 10 Q9Y5K8,Q9UI12,Q93050,Q9Y487 4
Muscle contraction 0.4714802160248635 1.5103726707343743 0.1309483580671855 1.0 0.8394283896854015 22 Q9NYL9,P35609,O43865,P06753,Q05682,P08670,P67936 7
Synaptic adhesion like molecules 0.7379002661662768 1.505143979296634 0.1322870641775306 1.0 0.8400846739124493 5 P41440 1
Signaling by fgfr1 in disease 0.6227262646472878 1.49762974602841 0.1342294739119545 1.0 0.8484551397504473 8 O95429,P62993,O95684 3
Egfr downregulation 0.6674108497515125 1.4880772190701057 0.1367305305077835 1.0 0.8523706007343017 6 Q92783 1
Mitotic g2 g2 m phases 0.3568425686330683 1.4691953634360095 0.1417798075405514 1.0 0.8679223353495917 80 Q9UL46,P62258,O75935,P07437,Q99640,Q9H6D7,Q99436,P68371,Q06323,P28074,Q13885,Q15154,P28072,P60900,P49721,P49720,O94927,O95684,O00231,P28070,P53350 21
Miscellaneous transport and binding events 0.8359545426870129 1.4651063464905103 0.1428919054279815 1.0 0.8688256042000195 4 Q8N4V1,Q8N8Q9 2
Metabolism of folate and pterines 0.6158189283580521 1.4635530106654946 0.1433161194518493 1.0 0.8688256042000195 8 Q9H2D1,P41440 2
Ros and rns production in phagocytes 0.5994661592721333 1.4616202623934895 0.1438452987086125 1.0 0.8688256042000195 9 Q9Y5K8,Q9UI12,Q93050,Q9Y487 4
Switching of origins to a post replicative state 0.375535995743376 1.4469337573270828 0.1479154774120856 1.0 0.8720627455903112 54 P28074,Q14566,O00231,Q9UBD5,P28072,Q9Y619,Q9UJX3,Q9UL46,Q9UJX2,Q96DE5,Q99436,P49720,P60900,P28070,Q06323,P49721 16
Ire1alpha activates chaperones 0.4576059528675584 1.4385581972451975 0.1502757374108911 1.0 0.8720627455903112 23 P51858,Q9NWM8,P02545,O14773,P43307 5
Death receptor signalling 0.4571910703017004 1.4354783861274725 0.151150823117196 1.0 0.8720627455903112 23 P42574,Q92974,Q14155,P42575,O95429,Q8TCT8,O15111,P62258,Q9NQC3,Q92769 10
Depolymerisation of the nuclear lamina 0.6085677318163984 1.4277040325533816 0.1533770649965216 1.0 0.8720627455903112 8 P02545,Q9Y2U8,P20700,P42166 4
Tyrosine catabolism 0.8682785997834679 1.4158922201780426 0.1568070631027691 1.0 0.8720627455903112 2 P16930 1
Regulation of plk1 activity at g2 m transition 0.4309088697566262 1.4140956081787297 0.1573338324814956 1.0 0.8720627455903112 29 O75935,Q9H6D7,Q15154,O94927,O95684,P62258,P68371,P53350 8
Polo like kinase mediated events 0.914488912515622 1.3996042509366775 0.1616318603089497 1.0 0.8720627455903112 3 P53350 1
Diseases of carbohydrate metabolism 0.5832435051391036 1.3785428768102437 0.168035739283495 1.0 0.8720627455903112 9 P46976,P13807,P54802,P10253,P08236 5
Activation of bad and translocation to mitochondria 0.580847521759794 1.3662430810761932 0.1718626796620075 1.0 0.8720627455903112 9 P27348,P31946,P31751,Q04917,P62258,P61981 6
Extra nuclear estrogen signaling 0.4873383789420765 1.3660997560534789 0.171907654870381 1.0 0.8720627455903112 15 P31751,P04899,P04792 3
Dap12 interactions 0.7029433765261806 1.357742265727352 0.1745454803532502 1.0 0.8720627455903112 5 P62993,P10321,P01889 3
Inhibition of replication initiation of damaged dna by rb1 e2f1 0.6371243623811852 1.34976427601421 0.1770916073006976 1.0 0.8720627455903112 6 P30153,Q14181,P49642,P30154 4
Mitotic metaphase and anaphase 0.3106684214461442 1.3454017304612194 0.1784955367415426 1.0 0.8720627455903112 125 P37198,Q7Z3B4,Q9UL46,Q8NBT2,Q29RF7,P52948,P02545,Q9Y6G9,Q9UJX3,Q99436,P68371,O00487,Q86XL3,Q06323,P28074,Q9Y2U8,P20700,Q13885,Q9BZD4,P28072,Q9UJX2,Q53HL2,P60900,P49721,Q8N1F7,Q96DE5,P49720,Q92973,O75832,O00231,Q2NKX8,P28070,P53350,P42166 34
Phospholipid metabolism 0.4131431159196504 1.3440999718271545 0.1789160612253937 1.0 0.8720627455903112 36 O95674,Q9UG56,Q9NPH0,P40939,Q8IV08,Q10713,P35790,Q8NCC3 8
Synthesis of dna 0.3476967523865489 1.3414052273314765 0.1797889213249848 1.0 0.8720627455903112 79 Q14566,Q9UL46,Q9UBD5,Q9NR33,Q9UJX3,Q99436,Q06323,P41440,P28074,P28072,P18858,P49642,Q9UJX2,P60900,P49721,Q14691,Q9Y619,Q96DE5,Q9BRT9,P49720,O00231,P28070 22
Long term potentiation 0.8029918649160946 1.337247965943343 0.1811417096523642 1.0 0.8720627455903112 4 P35609 1
Unblocking of nmda receptors glutamate binding and activation 0.8029918649160946 1.337247965943343 0.1811417096523642 1.0 0.8720627455903112 4 P35609 1
Ras activation upon ca2 influx through nmda receptor 0.8029918649160946 1.337247965943343 0.1811417096523642 1.0 0.8720627455903112 4 P35609 1
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.3957324606796455 1.3288951082701814 0.1838825779344761 1.0 0.8720627455903112 44 P28074,P28072,Q96DE5,Q9UJX3,Q9UL46,Q9UJX2,P49720,Q99436,O00231,P60900,P28070,P53350,Q06323,P49721 14
Signaling by alk 0.695104563652327 1.32458741696776 0.1853080316303175 1.0 0.8720627455903112 5 Q96ST3,Q92769 2
The role of gtse1 in g2 m progression after g2 checkpoint 0.3814525399569697 1.318311159357518 0.1873995068055332 1.0 0.8751887559473193 49 P28074,Q13885,P28072,Q9UL46,P49720,Q99436,O00231,P68371,P60900,P28070,P53350,Q06323,P49721 13
Cytoprotection by hmox1 0.3483170826445494 1.3183023671938765 0.1874024488452317 1.0 0.8751887559473193 62 P28074,P30519,P28072,P33527,Q96ST3,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721 13
Dna replication initiation 0.6294667043548737 1.3146678463932198 0.1886215572864578 1.0 0.8778653984667676 6 Q9NR33,P49642 2
Phase i functionalization of compounds 0.5014260087439046 1.3024187049540106 0.1927732917755025 1.0 0.8850638632530673 13 O43169,Q16850 2
Antigen processing cross presentation 0.3759959374101491 1.2936054751448245 0.1958017303074619 1.0 0.8899483327352534 50 P28074,Q06323,P10321,O75832,O15111,P28072,Q9UL46,P49720,P49721,Q99436,O00231,O00487,P60900,P28070,P01889,Q9UIQ6 16
S phase 0.3375606598905507 1.2874430147424196 0.1979399197172004 1.0 0.8933055647597645 89 Q14566,Q9UL46,Q29RF7,P31751,Q9UBD5,Q9NR33,Q9UJX3,Q99436,P41440,Q06323,P28074,P28072,P18858,P49642,Q9UJX2,P60900,P49721,Q14691,Q9Y619,Q96DE5,Q9BRT9,P49720,O00231,P28070 24
Cdt1 association with the cdc6 orc origin complex 0.4001388651799941 1.285262907078342 0.1987004275025128 1.0 0.8933055647597645 39 P28074,O75832,Q9UBD5,P28072,Q9Y619,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 14
Suppression of phagosomal maturation 0.6159042380682587 1.25242852578372 0.2104137573362172 1.0 0.8964021825075839 6 Q9UI12,P20339,P52294,Q14974 4
Response to elevated platelet cytosolic ca2 0.4080739649920089 1.2328107168187543 0.2176463920572364 1.0 0.9073050515514858 30 P07602,O43852,P12814,Q8NBX0,Q9NUQ9,Q9Y6I9,Q9NTK5,P35609 8
Cdc6 association with the orc origin complex 0.8206423673763952 1.220292595404201 0.2223539757781476 1.0 0.920920397623056 2 Q9UBD5 1
Cooperation of prefoldin and tric cct in actin and tubulin folding 0.4528152153789945 1.2130456220944894 0.2251123783819137 1.0 0.920920397623056 17 P61758,O15212,P04350,P49368,Q13885,Q9UHV9,Q99471,P68371 8
Smac xiap regulated apoptotic response 0.8163118007939322 1.202596757673259 0.2291324029976327 1.0 0.920920397623056 2 Q9NR28 1
Heme degradation 0.6655211070730508 1.1993303693460762 0.2303995108107719 1.0 0.920920397623056 5 P33527 1
Trafficking of myristoylated proteins to the cilium 0.8568612873120255 1.186650780550551 0.2353653968845492 1.0 0.9224797998370938 3 A6NIH7 1
Egr2 and sox10 mediated initiation of schwann cell myelination 0.7630845725312898 1.182397597531136 0.2370479760308659 1.0 0.9224797998370938 4 P46939,Q16850 2
Myoclonic epilepsy of lafora 0.8094550703717056 1.174622854940631 0.2401456354502693 1.0 0.9224797998370938 2 P46976 1
Orc1 removal from chromatin 0.3699308362772668 1.1685315735676292 0.2425924111198432 1.0 0.9224797998370938 48 P28074,Q14566,Q9UBD5,P28072,Q9Y619,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721 13
Nrage signals death through jnk 0.5957201075480983 1.1597137782201097 0.2461653585789247 1.0 0.92328932169684 6 Q14155 1
Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 0.8482967853220689 1.1551484534241427 0.2480296391186116 1.0 0.92328932169684 3 Q15404 1
Mastl facilitates mitotic progression 0.6549855570094427 1.1547346562585998 0.2481991029580903 1.0 0.92328932169684 5 P06493,P30154,O43768 3
Clathrin mediated endocytosis 0.3728076486750227 1.146817465751418 0.2514570691460269 1.0 0.9276669404766068 46 Q14108,P02786,P11717,Q7L5N1,P62993,Q9BT78,O43493,P20645,Q99627,Q14C86,Q9NVZ3,Q92783,Q8NC96,P20339 14
Intraflagellar transport 0.523299625688935 1.1441397462370897 0.2525656865168098 1.0 0.9276669404766068 10 Q9Y496,Q13885,P68371,Q92973 4
Mapk family signaling cascades 0.3278989945627075 1.1420646273794397 0.2534271572723872 1.0 0.9283221205745934 88 P49356,P41240,Q9UL46,O60725,Q9Y2Q5,Q96S59,P49354,Q99436,O00487,O43924,Q13813,Q06323,P28074,Q99956,Q14168,P28072,P62993,P60900,P35609,P04792,P49721,P20936,P07196,P49720,O75832,O00231,P28070 27
Sulfur amino acid metabolism 0.5221040691188797 1.1377471968247277 0.2552260594580049 1.0 0.9323984268909372 10 Q9BV57,Q13126 2
Phenylalanine and tyrosine metabolism 0.6505454046398697 1.1359522089465166 0.2559765661824236 1.0 0.9326331191472216 5 P61457,P16930 2
Signaling by the b cell receptor bcr 0.3679088439865423 1.121364944328335 0.2621325515915083 1.0 0.9474418553533503 47 P28074,O95999,O75832,O43865,O15111,P62993,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 16
Abc transporter disorders 0.3770995503768387 1.1111874734799876 0.2664876619870888 1.0 0.9505426053555216 42 P28074,Q9BUN8,O75832,Q9GZP9,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 14
Defective cftr causes cystic fibrosis 0.3770995503768387 1.1111874734799876 0.2664876619870888 1.0 0.9505426053555216 42 P28074,Q9BUN8,O75832,Q9GZP9,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 14
Regulation of pten stability and activity 0.3732410773424209 1.1085914180591707 0.2676064819985257 1.0 0.9520345786282632 44 P28074,P31751,O75832,P28070,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,Q9UNE7,Q06323,P49721 14
Carboxyterminal post translational modifications of tubulin 0.581834563977945 1.0959639928458909 0.2730945323142193 1.0 0.9552795682710872 6 P04350,P68371,Q13885 3
Regulation of ras by gaps 0.3790448263342693 1.0904666561767844 0.2755076335815247 1.0 0.9552795682710872 39 P28074,O75832,P20936,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 13
Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.5118025554226426 1.0826820124055505 0.2789495907619643 1.0 0.9552795682710872 10 P27348,P31946,P06493,Q04917,P62258,P61981 6
M phase 0.3108579850389646 1.0822826732860442 0.2791269426127054 1.0 0.9552795682710872 171 Q9Y6X3,P37198,P42166,P30154,Q7Z3B4,Q9UL46,Q8NFH4,O75935,P62258,P07437,O60763,Q8NBT2,Q29RF7,Q9H6D7,P52948,P02545,Q9Y6G9,Q9UJX3,Q99436,O00487,Q86XL3,P68371,O95235,Q06323,P28074,Q9Y2U8,P20700,Q9BTX1,Q9BSJ2,Q13885,Q9BZD4,Q15154,P28072,Q9UJX2,Q53HL2,P60900,P49721,P20618,Q92973,Q01105,O75832,Q99567,Q8N1F7,Q96DE5,P49720,O94927,O95684,O00231,Q2NKX8,P28070,P53350,P61981 52
Auf1 hnrnp d0 binds and destabilizes mrna 0.3735524132562772 1.0772418453704895 0.2813722353147005 1.0 0.9552795682710872 42 P28074,P28070,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P04792,Q06323,P49721 11
Rhobtb gtpase cycle 0.3936754919163712 1.0731900650136743 0.2831858473526294 1.0 0.9552795682710872 27 P61201,P62995,P78371,Q9NYL9,P12814,Q8N684,O75116,Q12792,Q9BT78,Q16543,P08670 11
Ion transport by p type atpases 0.5371119103553188 1.0719229235424674 0.2837546529807722 1.0 0.9552795682710872 8 P35670 1
Tbc rabgaps 0.4788461019781303 1.0674465880400696 0.2857702204392769 1.0 0.9552795682710872 12 P49815,Q9Y3P9 2
Deubiquitination 0.3243698459235916 1.06000322473262 0.2891431322728388 1.0 0.9552795682710872 84 P28074,P45880,Q96RU2,O00231,Q15388,Q7Z434,P28072,Q96K76,Q9UL46,P21796,Q8NB78,P28070,Q92783,P49721 14
Apc c mediated degradation of cell cycle proteins 0.3540777558338561 1.0599721276623963 0.2891572797359167 1.0 0.9552795682710872 50 P28074,P28072,Q96DE5,Q9UJX3,Q9UL46,Q9UJX2,P49720,Q99436,O00231,P60900,P28070,P53350,Q06323,P49721 14
Regulation of localization of foxo transcription factors 0.5479057057359368 1.0564943294310631 0.2907424301894119 1.0 0.9552795682710872 7 P27348,P31946,P63104,P31751,P61981 5
Gaba receptor activation 0.5730357682743301 1.0556229195986244 0.2911405253759764 1.0 0.9552795682710872 6 P04899,P63218 2
Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.4428697467487617 1.0503380543244607 0.2935627150325917 1.0 0.9552795682710872 14 Q9BTY2,Q07065,Q86UP2,O43852 4
Factors involved in megakaryocyte development and platelet production 0.3739063497949217 1.0429779509175208 0.2969585047917731 1.0 0.9552795682710872 39 P33176,Q9Y496,Q96ST3,Q92769,P20339,O00139,P47756,P10644,Q9H0B6,Q14807,P68371,Q07866,O95235,P04350,Q13885,P45973,Q9NSK0,P52732,Q9H0H5,O95140 20
Nade modulates death signalling 0.8166064981949442 1.0392425342293998 0.2986919533367924 1.0 0.9552795682710872 3 P62258,P42575 2
Ub specific processing proteases 0.3265225101077251 1.0377485063504328 0.2993871558631611 1.0 0.9552795682710872 68 P28074,P45880,Q96RU2,Q96K76,P28072,Q9UL46,P21796,O00231,P28070,P49721 10
Regulation of runx3 expression and activity 0.3748092136108091 1.0335685197046247 0.3013379225619084 1.0 0.9552795682710872 38 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Sensory perception 0.4056620276709347 1.0263595999651762 0.3047221136517009 1.0 0.9552795682710872 22 P49354,P09455 2
Gamma carboxylation hypusine formation and arylsulfatase activation 0.5138133211953216 1.020742127085189 0.3073766298685003 1.0 0.9552795682710872 9 O43681,P38435,O60725 3
G beta gamma signalling through pi3kgamma 0.622662472554357 1.0183269193691724 0.3085226195669279 1.0 0.9552795682710872 5 P31751 1
Signaling by fgfr4 in disease 0.7704799711295538 1.0170119152845205 0.3091477611639106 1.0 0.9552795682710872 2 P62993 1
Cyclin a cdk2 associated events at s phase entry 0.36716986325973 1.0161841518896455 0.3095417017991371 1.0 0.9552795682710872 42 P28074,P20618,P31751,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 14
Signaling by hedgehog 0.3302936732365319 1.0145591375623493 0.3103160260958422 1.0 0.9552795682710872 56 P28074,P10644,Q9Y496,Q13885,Q9GZP9,P28072,Q9UL46,P49720,Q99436,O00231,P68371,P60900,P28070,Q06323,P49721 15
Glycogen storage diseases 0.8097472924187707 1.014331046314792 0.3104248145253809 1.0 0.9552795682710872 3 P46976,P10253 2
Signaling by egfr 0.4830463167973628 1.0044029593638657 0.3151844241700101 1.0 0.9552795682710872 11 P41240,P62993,Q14155,Q92783 4
Translocation of slc2a4 glut4 to the plasma membrane 0.3764988638663834 0.9965246543378296 0.3189952942017446 1.0 0.9552795682710872 34 Q96A65,P31751,Q9Y496,Q96KP1,P62258,P68371,Q9UIQ6 7
Plasma lipoprotein clearance 0.4815662690603202 0.9962194838425498 0.3191435146407899 1.0 0.9552795682710872 11 Q8WTV0 1
Methionine salvage pathway 0.6173530498819384 0.9960223578796712 0.3192392821172072 1.0 0.9552795682710872 5 Q9BV57 1
Copi dependent golgi to er retrograde traffic 0.359690273492137 0.994159849239834 0.3201450518202504 1.0 0.9552795682710872 45 O00139,P54920,Q9NSK0,P48444,O14579,Q6NUQ1,P24390,P35606,P52732,Q9Y496,Q13885,Q9P2W9,Q9H0H5,Q9H0B6,Q14807,P68371,Q07866,O95235 18
Dna replication 0.3192924082549064 0.990710034383573 0.3218271898949343 1.0 0.9552795682710872 84 Q14566,Q9UL46,Q9UBD5,Q9NR33,Q9UJX3,Q99436,Q06323,P41440,P28074,P28072,P18858,P49642,Q9UJX2,P60900,P49721,Q14691,Q9Y619,Q96DE5,Q9BRT9,P49720,O00231,P28070 22
Stat3 nuclear events downstream of alk signaling 0.7133255303784554 0.9906801272644068 0.3218417978584607 1.0 0.9552795682710872 4 Q96ST3 1
Unwinding of dna 0.4805562572335016 0.9906368888880008 0.3218629181645411 1.0 0.9552795682710872 11 Q14566,Q14691 2
Dna replication pre initiation 0.32112897535292 0.9848475391000772 0.3246989653847139 1.0 0.9552795682710872 61 P28074,Q14566,Q9UBD5,P28072,Q9NR33,Q9UL46,P49642,Q9Y619,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721 15
Hedgehog ligand biogenesis 0.3647200061399732 0.9794746559370946 0.3273455052097231 1.0 0.9552795682710872 41 P28074,O75832,Q9GZP9,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 13
Degradation of dvl 0.368737224752957 0.978274941063237 0.3279383602464794 1.0 0.9552795682710872 38 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Rho gtpase cycle 0.2932346939569589 0.9771714219807436 0.3284842935718177 1.0 0.9552795682710872 136 O15173,Q9UQB8,P06753,O75976,Q9UNZ2,Q16543,Q13505,Q96HY6,Q8NBN3,Q07065,Q86XL3,Q13813,P41440,O75489,P20700,P30519,Q9NYL9,P08670,P62993,P67936,Q86UP2,Q92783,Q92974,Q14155,Q9H0H5,P12814,O75116,Q9BT78,P42166 29
Antigen activates b cell receptor bcr leading to generation of second messengers 0.7989560475587023 0.9752982681180024 0.3294123293173787 1.0 0.9552795682710872 3 O43865 1
Neurotransmitter clearance 0.7596535546733985 0.973791091198303 0.3301602773994836 1.0 0.9552795682710872 2 P21964 1
Degradation of axin 0.369657923867354 0.971565630438959 0.3312666879270325 1.0 0.9552795682710872 37 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Cross presentation of soluble exogenous antigens endosomes 0.369657923867354 0.971565630438959 0.3312666879270325 1.0 0.9552795682710872 37 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Rho gtpases activate ktn1 0.5039297982842845 0.969925136261349 0.332083809709649 1.0 0.9552795682710872 9 Q07866,Q86UP2,Q9H0B6 3
Signaling by cytosolic fgfr1 fusion mutants 0.6110249088681894 0.9694918754726378 0.3322998319104338 1.0 0.9552795682710872 5 O95684 1
Activation of bh3 only proteins 0.4763870081759936 0.9676107465824232 0.3332388081419242 1.0 0.9552795682710872 11 P27348,P31946,P31751,Q04917,P62258,P61981 6
Disorders of transmembrane transporters 0.3207621747251518 0.9662788881571802 0.3339046472492257 1.0 0.9552795682710872 73 Q9BUN8,Q7Z3B4,Q9UL46,P52948,Q99436,O00487,Q06323,P28074,Q9BTX1,P28072,P53985,P60900,P49721,P20618,Q9GZP9,Q8N1F7,P49720,O75832,O00231,P28070,P37198 21
Fcgamma receptor fcgr dependent phagocytosis 0.3786495372200461 0.953609733805536 0.3402812267817217 1.0 0.9594236248887132 27 Q9UQB8 1
Cdc42 gtpase cycle 0.3852969472081487 0.9480461167298928 0.3431059774503691 1.0 0.959696610167494 25 Q9UQB8,Q14155 2
Transport of connexons to the plasma membrane 0.6047812149383192 0.9433803748897848 0.3454863776486463 1.0 0.959696610167494 5 P04350,P68371,Q13885 3
Gap junction assembly 0.6047812149383192 0.9433803748897848 0.3454863776486463 1.0 0.959696610167494 5 P04350,P68371,Q13885 3
Nuclear envelope ne reassembly 0.3523563682019314 0.9409438124091444 0.3467336538574241 1.0 0.959696610167494 46 Q14739,Q7Z3B4,Q8NFH4,P06493,P57740,P30153,P52948,Q8NFH5,P02545,Q9BVL2,P68371,Q86XL3,Q9Y2U8,P20700,Q9BTX1,P04350,Q13885,P53990,Q9BVA1,Q14974,Q8N1F7,Q92973,P37198,P42166 24
Smooth muscle contraction 0.4709104163912131 0.9374155485122504 0.348544846027826 1.0 0.9604319507325896 11 P06753,Q05682,P67936 3
Mucopolysaccharidoses 0.6975530366173986 0.930601723492214 0.352059622651617 1.0 0.9604319507325896 4 P08236,P54802 2
Tcr signaling 0.3469410231063541 0.9305474728756012 0.3520876964995496 1.0 0.9604319507325896 48 P28074,P20618,O95999,O75832,P41240,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,P19174,Q06323,P49721 17
Signaling by erbb4 0.5205282798557334 0.9250477953895088 0.3549410463740641 1.0 0.9604319507325896 7 P61201,P62993,P46934,P16949 4
Hedgehog on state 0.3574441255489828 0.9233098290077496 0.3558457671426684 1.0 0.9604319507325896 42 P28074,O75832,Q9Y496,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 13
Asymmetric localization of pcp proteins 0.3615506600102837 0.9129660618135248 0.3612603911290968 1.0 0.9623109060947864 38 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Signaling by ntrk3 trkc 0.6912242686890413 0.9066312647091306 0.3646018227394769 1.0 0.9623109060947864 4 Q8WX92,P62993,P19174 3
Antigen presentation folding assembly and peptide loading of class i mhc 0.4330990615877851 0.8901359917940351 0.3733928690463268 1.0 0.9712074284278646 13 P10321,Q9NZ08 2
Hedgehog off state 0.3380687839841637 0.88945013587664 0.3737612104987293 1.0 0.9712074284278646 50 P28074,P10644,Q9Y496,Q13885,P28072,Q9UL46,P49720,Q99436,O00231,P68371,P60900,P28070,Q06323,P49721 14
Stabilization of p53 0.3561335536171667 0.8880170353943357 0.3745315878657727 1.0 0.9713519616595137 40 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Signaling by ptk6 0.4155613464520847 0.8781855073220997 0.3798430555918761 1.0 0.97950513517174 14 P18031,Q07666,P11802,P31749,P23246,Q96JJ3,Q8IZL8,P20936 8
Transcriptional regulation by runx3 0.3524157955589958 0.8754340936277187 0.3813377558815283 1.0 0.97950513517174 42 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Vegfr2 mediated cell proliferation 0.7707581227436799 0.8744212529533144 0.3818888874883686 1.0 0.97950513517174 3 P20936,O43865 2
Role of phospholipids in phagocytosis 0.7707581227436792 0.8744212529533127 0.3818888874883694 1.0 0.97950513517174 3 Q8IV08,O43865 2
Rac3 gtpase cycle 0.3645508029846798 0.8718402111118057 0.3832955544875189 1.0 0.97950513517174 29 Q9UQB8,Q9H0H5 2
Downstream signaling events of b cell receptor bcr 0.3487299961717887 0.8685973782337915 0.3850673890017408 1.0 0.97950513517174 44 P28074,O95999,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 14
Rhobtb1 gtpase cycle 0.3965058361151227 0.8654008617539432 0.3868188081854571 1.0 0.97950513517174 18 P61201,P62995,P78371,Q8N684,O75116,Q9BT78,P08670 7
G protein beta gamma signalling 0.5308322068720335 0.8635521593141593 0.3878339545482001 1.0 0.9796772197602304 6 P31751 1
Transcriptional regulation by e2f6 0.5299642708574875 0.859640423231339 0.3899872849870145 1.0 0.9804730857633908 6 Q13185 1
Diseases of signal transduction by growth factor receptors and second messengers 0.2847570309207412 0.8585906433848457 0.3905664020489836 1.0 0.9804730857633908 132 Q9P2E9,P41240,O95429,P06753,Q9UL46,Q16543,Q92769,P10644,P31751,P02545,O43815,Q99436,O00487,Q07866,Q06323,P28074,P51114,Q99956,Q6UN15,O15111,P28072,P62993,P67936,P60900,P49721,Q14789,O75832,Q9GZP9,P06748,P49720,Q9NRY5,O95684,O00231,P49815,P28070 35
G alpha s signalling events 0.5295379112538994 0.8577195996748779 0.3910473147178304 1.0 0.9804730857633908 6 P04899 1
Metalloprotease dubs 0.5288687233291758 0.854705806634151 0.3927140351485665 1.0 0.9804730857633908 6 O95630,O00487,Q92783 3
Metabolism of lipids 0.294634877690084 0.8541877222233819 0.3930009849211004 1.0 0.9804730857633908 161 O15254,Q8N8N7,O43772,Q96ST3,Q15392,P38435,P35790,Q8NCC3,Q16850,P06865,P06280,P23786,P20339,Q96G23,P37268,Q9NPH0,P40939,P50897,P33527,Q9UMR5,Q8IV08,O43681,O95674,P07602,O15269,Q15165,Q10713,Q9UG56,Q06520 29
Gaba b receptor activation 0.5808697435002625 0.8441363441109281 0.3985932205712597 1.0 0.9804730857633908 5 P04899 1
G alpha z signalling events 0.5808697435002625 0.8441363441109281 0.3985932205712597 1.0 0.9804730857633908 5 P04899 1
Adp signalling through p2y purinoceptor 12 0.5808697435002625 0.8441363441109281 0.3985932205712597 1.0 0.9804730857633908 5 P04899 1
Regulation of runx2 expression and activity 0.3489717044711322 0.8427218521636006 0.3993840228708967 1.0 0.9804730857633908 42 P28074,O75832,P28070,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,Q9UNE7,Q06323,P49721 13
G1 s dna damage checkpoints 0.350082525295017 0.8417219268712013 0.3999436218107099 1.0 0.9804730857633908 41 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
E2f enabled inhibition of pre replication complex formation 0.6735194539553172 0.8400718680231779 0.4008680922262218 1.0 0.9804730857633908 4 Q9Y619,Q9UBD5 2
Negative regulation of notch4 signaling 0.349878242128814 0.839807360424607 0.4010164058850618 1.0 0.9804730857633908 41 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Metabolism of polyamines 0.3513054966874797 0.8348925793002087 0.4037781932911057 1.0 0.9804730857633908 39 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Fc epsilon receptor fceri signaling 0.3245641525517961 0.8337831770787906 0.4044031768816483 1.0 0.9804730857633908 53 P28074,P20618,O95999,O75832,O43865,O15111,P62993,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,P19174,Q06323,P49721 18
Scf skp2 mediated degradation of p27 p21 0.3499327745579542 0.8305046318315119 0.4062535301423613 1.0 0.9804730857633908 40 P28074,P20618,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 13
Hs gag degradation 0.7577617328519823 0.828590903503616 0.4073359370653922 1.0 0.9804730857633908 3 P08236,P54802 2
Heparan sulfate heparin hs gag metabolism 0.7577617328519823 0.828590903503616 0.4073359370653922 1.0 0.9804730857633908 3 P08236,P54802 2
Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0.4879261245555952 0.828297005195727 0.4075023184697437 1.0 0.9804730857633908 8 P35609 1
Cooperation of pdcl phlp1 and tric cct in g protein beta folding 0.4367667331435709 0.825826874761259 0.4089023066549795 1.0 0.9804730857633908 12 P49368 1
Phosphorylation of the apc c 0.4749744418125619 0.8221718003285011 0.4109791258127715 1.0 0.9807774124363088 9 Q96DE5,Q9UJX3,P53350 3
Rhob gtpase cycle 0.3891987161997547 0.8155268413614828 0.4147708068005893 1.0 0.9807774124363088 18 Q92974,Q9H0H5,P41440 3
Sealing of the nuclear envelope ne by escrt iii 0.4735207465572593 0.8148166142474041 0.415177289336212 1.0 0.9807774124363088 9 P04350,P68371,Q13885,P53990 4
Aryl hydrocarbon receptor signalling 0.7515805195955418 0.8069668134699157 0.4196856032794807 1.0 0.9807774124363088 3 O00170 1
Plasma lipoprotein assembly remodeling and clearance 0.4190924630150635 0.8067283247890307 0.4198230215021872 1.0 0.9807774124363088 13 Q8WTV0 1
Nuclear envelope breakdown 0.3497702779044484 0.8064458890844179 0.4199857963909996 1.0 0.9807774124363088 38 P35658,Q7Z3B4,Q8NFH4,P12270,P06493,P57740,P52948,Q8NFH5,P02545,Q9BVL2,O75531,Q9Y2U8,P20700,Q9BTX1,Q99567,Q8N1F7,P53350,P37198,P42166 19
Assembly and cell surface presentation of nmda receptors 0.4593914117392615 0.804806857773664 0.4209311436817504 1.0 0.9807774124363088 10 Q13885,Q14168,P07196,P68371,P35609 5
Retrograde transport at the trans golgi network 0.3956274544643695 0.800078176467852 0.4236655044584609 1.0 0.9807774124363088 16 O60664,O43493,P11717,P83436,P53365,P20645,Q9UID3 7
Amino acid transport across the plasma membrane 0.7134608444604795 0.7934790648426521 0.4274987618567412 1.0 0.9807774124363088 2 P08195 1
Nuclear signaling by erbb4 0.7476534296028855 0.7932910963553578 0.4276082430771855 1.0 0.9807774124363088 3 P61201,P16949 2
Regulation of hmox1 expression and activity 0.3406477494645241 0.7900478479449532 0.4294998252938717 1.0 0.9807774124363088 44 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Nephrin family interactions 0.4686094473589817 0.7900244483400132 0.4295134904497848 1.0 0.9807774124363088 9 P12814,P35609,Q13813 3
Traf6 mediated nf kb activation 0.658182346033841 0.78311552933125 0.4335592726328965 1.0 0.9807774124363088 4 Q7Z434 1
Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 0.7442704097318975 0.78155081928733 0.4344785995774731 1.0 0.9807774124363088 3 Q7Z434 1
Cyclin a b1 b2 associated events during g2 m transition 0.4549264152544991 0.7814908879339763 0.4345138339120544 1.0 0.9807774124363088 10 P53350 1
Insulin processing 0.4768181017009016 0.7740878100063732 0.4388788656464371 1.0 0.9807774124363088 8 Q96KP1 1
Constitutive signaling by ligand responsive egfr cancer variants 0.6555161457297698 0.7732907043041202 0.4393503558848346 1.0 0.9807774124363088 4 P62993,Q16543 2
Signaling by erbb2 ecd mutants 0.6555161457297698 0.7732907043041202 0.4393503558848346 1.0 0.9807774124363088 4 P62993,Q16543 2
Constitutive signaling by egfrviii 0.6555161457297698 0.7732907043041202 0.4393503558848346 1.0 0.9807774124363088 4 P62993,Q16543 2
Signaling by erbb2 in cancer 0.6555161457297698 0.7732907043041202 0.4393503558848346 1.0 0.9807774124363088 4 P62993,Q16543 2
Signaling by egfr in cancer 0.6555161457297698 0.7732907043041202 0.4393503558848346 1.0 0.9807774124363088 4 P62993,Q16543 2
Rac1 gtpase cycle 0.3506905065619928 0.7688749937019165 0.4419675236067055 1.0 0.9807774124363088 33 Q9UQB8,Q14155 2
The phototransduction cascade 0.7394921381118253 0.7650353290941115 0.4442505074845004 1.0 0.9807774124363088 3 P49354 1
Mitotic prometaphase 0.3044117093458539 0.7637606632912461 0.4450098825241604 1.0 0.9807774124363088 78 Q8NBT2,Q29RF7,Q9H6D7,P62258,Q9BZD4,Q15154,Q9Y6G9,O94927,O95684,O75935,P68371,Q2NKX8,P07437,P53350,Q53HL2 15
Signaling by pdgfr in disease 0.5586644396891991 0.7534102825191136 0.4512034057251706 1.0 0.9807774124363088 5 P62993,O43815 2
Fceri mediated nf kb activation 0.3343178975933114 0.7438235212852097 0.4569832482630422 1.0 0.9807774124363088 45 P28074,P20618,O95999,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 15
Platelet aggregation plug formation 0.503969318753252 0.7435999560267049 0.4571185298488744 1.0 0.9807774124363088 6 P41240,P18031,P62993,P31749 4
Integrin signaling 0.503969318753252 0.7435999560267049 0.4571185298488744 1.0 0.9807774124363088 6 P41240,P18031,P62993,P31749 4
Transcriptional regulation by runx2 0.3190202711350715 0.7417817263433037 0.4582195939414215 1.0 0.9807774124363088 52 P28074,P20618,P31751,O75832,P28070,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,Q9UNE7,Q06323,P49721 15
Tnfr2 non canonical nf kb pathway 0.3380232165272532 0.7393205440240809 0.459712377285467 1.0 0.9807774124363088 42 P28074,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 13
Dectin 1 mediated noncanonical nf kb signaling 0.3380232165272531 0.7393205440240801 0.4597123772854674 1.0 0.9807774124363088 42 P28074,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 13
Formation of the early elongation complex 0.4211285068553096 0.7375869809460672 0.4607654691645129 1.0 0.9807774124363088 12 Q8WX92,Q8IXH7 2
Signaling by vegf 0.3488854152154302 0.7196822063404871 0.4717206842995665 1.0 0.9832669046317036 27 P31751,Q9UQB8,P04792 3
Mitotic g1 phase and g1 s transition 0.3015124015853728 0.7193598850757305 0.471919206739736 1.0 0.9832669046317036 74 Q14566,P11802,Q9UL46,P31751,Q9UBD5,Q9NR33,Q99436,O00487,Q06323,P28074,P28072,P49642,P60900,P49721,P20618,Q9Y619,Q14181,P49720,O75832,O00231,P28070 21
Signaling by notch4 0.3343745865311683 0.716403410393116 0.4737422897209762 1.0 0.9832669046317036 43 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Notch4 activation and transmission of signal to the nucleus 0.6871165644171728 0.6946535785385253 0.4872724264331398 1.0 0.997403001456385 2 Q92542 1
Listeria monocytogenes entry into host cells 0.4710361531248672 0.6921101667177527 0.4888681474989853 1.0 0.9990553570693548 7 Q92783 1
Mitotic telophase cytokinesis 0.4221823167642943 0.6733526812972797 0.5007229447520423 1.0 1.0 11 Q9Y6X3,Q29RF7,P53350 3
Abortive elongation of hiv 1 transcript in the absence of tat 0.421971250936782 0.6722355848095012 0.5014337303417122 1.0 1.0 11 Q8WX92,Q8IXH7 2
Activation of the pre replicative complex 0.3627938954735742 0.667003329321934 0.5047700068064471 1.0 1.0 19 Q14566,Q9UBD5,Q9Y619,Q9NR33,P49642 5
Synthesis of pa 0.5361590230538711 0.663410374395538 0.507067763354035 1.0 1.0 5 Q9NPH0 1
Peptide hormone metabolism 0.4075620704073803 0.6622000141913303 0.5078430451213893 1.0 1.0 12 Q96KP1 1
Ptk6 regulates proteins involved in rna processing 0.6762901479610197 0.6551326299074358 0.5123823652282808 1.0 1.0 2 P23246 1
Rab regulation of trafficking 0.3366000895480556 0.6470044901652178 0.5176290374332326 1.0 1.0 30 Q9UL25,P31751,Q9Y3P9,Q14C86,P49815,P20339 6
Akt phosphorylates targets in the cytosol 0.5311856593249622 0.6438473763844165 0.5196744087318046 1.0 1.0 5 P31751,P49815 2
Intra golgi and retrograde golgi to er traffic 0.2935200013605341 0.6424124085636047 0.520605445035826 1.0 1.0 84 P24390,P35606,Q9Y496,P83436,O75935,Q9UJW0,O00139,P48444,Q10472,Q9Y6G9,Q9H0B6,Q14807,P53365,P20645,P68371,Q07866,O95235,Q9P2W9,Q13885,Q9UID3,P54920,O14579,Q6NUQ1,Q9NSK0,O60664,P52732,Q9H0H5,P11717,O00461,O43493 30
Separation of sister chromatids 0.2881961902494298 0.6406826662011075 0.521728878317639 1.0 1.0 94 Q9UL46,Q8NBT2,Q29RF7,Q9Y6G9,Q9UJX3,Q99436,P68371,Q06323,P28074,Q13885,Q9BZD4,P28072,Q9UJX2,Q53HL2,P60900,P49721,Q96DE5,P49720,O00231,Q2NKX8,P28070,P53350 22
Transport of bile salts and organic acids metal ions and amine compounds 0.7014440433212963 0.636746438299751 0.5242900196825429 1.0 1.0 3 P53985,Q8TAD4 2
Vxpx cargo targeting to cilium 0.4479126218111116 0.6355798452983844 0.5250503094679828 1.0 1.0 8 Q96KP1 1
Pten regulation 0.2923602506787039 0.6327856910008468 0.5268736021730185 1.0 1.0 61 P28074,Q06323,P31751,O75832,Q9Y2Q5,P28070,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,Q9UNE7,Q92769,P49721 16
Clec7a dectin 1 signaling 0.315667925794835 0.631503982794443 0.5277110458937506 1.0 1.0 49 P28074,O95999,O75832,O43865,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 15
Beta catenin independent wnt signaling 0.3058517158509882 0.6278718066857061 0.5300879214670005 1.0 1.0 53 P28074,O75832,P63218,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721 12
Signaling by flt3 fusion proteins 0.698194945848372 0.626093590177032 0.531253556249043 1.0 1.0 3 P62993,Q14789 2
Apoptotic cleavage of cellular proteins 0.3647539182812507 0.6255850694102416 0.5315871344292893 1.0 1.0 17 P35611,P20700,P02545,P49354,P08670,Q13813 6
Class b 2 secretin family receptors 0.6922518800041505 0.6067474803181317 0.5440185070761587 1.0 1.0 3 P63218 1
Activation of ampk downstream of nmdars 0.4517925929537328 0.6045172310468552 0.545499816734945 1.0 1.0 7 P04350,P54619,Q13885,P68371 4
Degradation of beta catenin by the destruction complex 0.3163708832310793 0.600590388199468 0.5481128414570371 1.0 1.0 47 P28074,P20618,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 13
Energy dependent regulation of mtor by lkb1 ampk 0.4497746582846066 0.5954682159849575 0.5515305387965626 1.0 1.0 7 Q9Y2Q5 1
Cellular response to hypoxia 0.3240103780942403 0.5938831648522477 0.5525902597886856 1.0 1.0 40 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 12
Interleukin 1 signaling 0.3168681220490659 0.5894498562641748 0.5555595402369748 1.0 1.0 46 P28074,P20618,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 14
Arachidonic acid metabolism 0.4272631785185358 0.5861006755988957 0.5578078623224438 1.0 1.0 9 Q8N8N7,P33527 2
Cholesterol biosynthesis 0.3582109238840918 0.5838060291582008 0.5593508214222604 1.0 1.0 17 P37268,Q16850,P14324,Q15392 4
Regulation of mrna stability by proteins that bind au rich elements 0.2883199046674123 0.5753519791941839 0.5650532740674368 1.0 1.0 63 P28074,Q01105,P28070,P28072,Q9UL46,P49720,Q92973,Q99436,O00231,P60900,P04792,Q06323,P49721 13
Flt3 signaling 0.5126218614231822 0.5720666719116315 0.5672768069938248 1.0 1.0 5 P31751,P62993 2
Constitutive signaling by overexpressed erbb2 0.6808476615155743 0.5701564136817926 0.5685716154572649 1.0 1.0 3 Q16543 1
Foxo mediated transcription of oxidative stress metabolic and neuronal genes 0.5944657458611907 0.5565861521783686 0.5778102172477064 1.0 1.0 4 Q96ST3 1
Uch proteinases 0.3161266536393706 0.5561032741296332 0.578140256982409 1.0 1.0 44 P28074,O00231,P28072,Q9UL46,P49720,Q99436,Q8NB78,P60900,P28070,Q06323,P49721 11
Downregulation of erbb2 signaling 0.4580742875594136 0.5465559886637786 0.5846838126140808 1.0 1.0 6 P31751,Q16543 2
Cell extracellular matrix interactions 0.4370414156375128 0.5390626085975434 0.5898436548401633 1.0 1.0 7 Q15404 1
Interferon gamma signaling 0.4069874362886456 0.5384596430621799 0.590259759535908 1.0 1.0 10 P10321 1
Inlb mediated entry of listeria monocytogenes into host cell 0.5018840878135744 0.5315566567891334 0.59503309099933 1.0 1.0 5 Q92783 1
Negative regulation of met activity 0.4539429842171268 0.5295021659892867 0.596457142280062 1.0 1.0 6 Q92783 1
Adrenaline noradrenaline inhibits insulin secretion 0.585963665116549 0.5279849962640649 0.5975097496201718 1.0 1.0 4 P04899 1
Arms mediated activation 0.6391194514615599 0.5254073081415573 0.5993000742298502 1.0 1.0 2 P31946 1
Rac2 gtpase cycle 0.3194120290138702 0.5152767888153098 0.6063596163112508 1.0 1.0 29 O15173,Q9H0H5,Q13505,Q86XL3,P42166 5
Deadenylation of mrna 0.3541016289850389 0.5059671881680237 0.6128796840515587 1.0 1.0 14 Q9UIV1,P23588,Q9UKZ1,Q92600 4
Pcp ce pathway 0.3064688347230853 0.5041414605219224 0.6141619736468984 1.0 1.0 47 P28074,O75832,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721 11
Thrombin signalling through proteinase activated receptors pars 0.4907894260922212 0.4905891293362219 0.6237170765305824 1.0 1.0 5 P63218 1
Thromboxane signalling through tp receptor 0.5742905602649389 0.4895026160592975 0.6244859028956267 1.0 1.0 4 P63218 1
Diseases of immune system 0.6279321544568679 0.4884615198367071 0.625222975483827 1.0 1.0 2 O15111 1
G2 m checkpoints 0.2822094345896098 0.4841221405958173 0.6282991890592182 1.0 1.0 81 P28074,Q14566,O96028,P62258,Q9UQ84,Q9UBD5,P28072,Q9Y619,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q99640,Q06323,P49721 17
Condensation of prometaphase chromosomes 0.4055716353111362 0.4840713461531163 0.6283352359557359 1.0 1.0 9 Q15021,P14635,Q9BPX3,P67870,O95347,Q15003,P19784,P06493 8
Tnf signaling 0.4239165924143607 0.4823328194977963 0.6295695364758047 1.0 1.0 7 O95429 1
Signaling by fgfr in disease 0.3494137474666965 0.4792045327429149 0.6317931299424697 1.0 1.0 14 O95684 1
Complex i biogenesis 0.324670167866977 0.4786399055252878 0.6321948241465192 1.0 1.0 24 Q9P0J0,Q7L592,P51970,O75306,Q8TB37,Q16718,O43676,O95168,O75489 9
Alk mutants bind tkis 0.4411834209670666 0.4777358297757492 0.6328382391626959 1.0 1.0 6 O43815,P10644 2
Pyruvate metabolism 0.3604423227837676 0.4723828039354186 0.636653576269135 1.0 1.0 13 P53985,P21796 2
Cell cycle checkpoints 0.2592942628455087 0.4677400477437833 0.6399704983616141 1.0 1.0 127 Q14566,Q9UL46,P62258,Q99640,Q8NBT2,Q9UBD5,Q9Y6G9,Q9UJX3,Q99436,Q06323,P28074,Q9BZD4,P28072,Q9UJX2,Q53HL2,Q9UQ84,P60900,P49721,O96028,Q9Y619,Q96DE5,P49720,O00231,Q2NKX8,P28070,P53350 26
Tp53 regulates transcription of cell cycle genes 0.3467303115412538 0.4640342919979387 0.6426231771415192 1.0 1.0 14 Q9UIV1,Q9UKZ1,Q92600 3
Notch hlh transcription pathway 0.6390912735227834 0.4430704392813143 0.6577147859866455 1.0 1.0 3 Q92769 1
Rho gtpases activate iqgaps 0.3867868977588702 0.4419541156156882 0.6585224096376943 1.0 1.0 10 P04350,P68371,Q13885,P35221 4
Gap filling dna repair synthesis and ligation in gg ner 0.3352831241481875 0.4419151039779277 0.6585506404933896 1.0 1.0 17 P18887,P18858,P41440 3
Apc c cdc20 mediated degradation of cyclin b 0.4049913363602797 0.4405605837608762 0.6595311435427287 1.0 1.0 8 Q96DE5,Q9UJX3,Q9UJX2,Q16763,P06493 5
Regulation of lipid metabolism by pparalpha 0.3378446792524653 0.4404395537565115 0.6596187826191535 1.0 1.0 16 Q06520,P37268,Q96ST3,Q71SY5,P23786 5
Signal amplification 0.4040356499027893 0.4364166914883358 0.6625344307825385 1.0 1.0 8 P04899 1
Runx1 regulates transcription of genes involved in differentiation of hscs 0.3044144755978435 0.4322141485910036 0.6655857770794698 1.0 1.0 42 P28074,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721 10
Regulation of pten localization 0.6088054853843305 0.4279106356967544 0.6687161834568778 1.0 1.0 2 P46934 1
Potential therapeutics for sars 0.308109923917279 0.4273580958156714 0.6691185239288289 1.0 1.0 30 P49356,Q15185,O75116,P21964,P49354,P07437 6
Interleukin 1 family signaling 0.2967598860999216 0.4262063009413349 0.6699575265617685 1.0 1.0 48 P28074,P20618,O75832,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 14
Chaperone mediated autophagy 0.4278491326606558 0.4252630166231135 0.6706449506169807 1.0 1.0 6 P08670 1
Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.3166702326384342 0.4239039942263096 0.6716358310776553 1.0 1.0 24 P20700,P78417,P52597,O00170,Q9UL46,Q13126 6
Tcf dependent signaling in response to wnt 0.2759438806425787 0.421289650201063 0.6735435869047977 1.0 1.0 57 P28074,P31751,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721 11
E3 ubiquitin ligases ubiquitinate target proteins 0.3340109719503855 0.4181478304858552 0.6758390361117013 1.0 1.0 16 Q9BUN8,O95999,P50542,O75150,Q14527 5
Neuronal system 0.2922757214007376 0.4164704150512391 0.6770658117260309 1.0 1.0 50 P10644,P04899,Q14155,P63218,Q9Y639,P07196,P68371,P35609,P21964,O95197,P41440 11
Cell cycle mitotic 0.2853512281500024 0.4150674906763106 0.67809249713712 1.0 1.0 225 Q9Y6X3,P37198,P42166,P11802,Q14566,P30154,Q7Z3B4,Q9UL46,Q8NFH4,O75935,P62258,P07437,Q99640,O60763,Q8NBT2,Q29RF7,Q9H6D7,P52948,P31751,P02545,Q9UBD5,Q9NR33,Q9Y6G9,Q9UJX3,Q99436,O00487,Q86XL3,P68371,O95235,P41440,Q06323,P28074,Q9Y2U8,P20700,Q9BTX1,Q9BSJ2,Q13885,Q9BZD4,Q15154,P28072,P18858,P49642,Q9UJX2,Q53HL2,P60900,P49721,P20618,Q92973,Q01105,O75832,Q99567,Q14691,Q8N1F7,Q9Y619,Q96DE5,Q9BRT9,Q14181,O94927,O95684,O00231,P49720,Q2NKX8,P28070,P53350,P61981 65
Programmed cell death 0.2689317397097804 0.4101831724835216 0.6816715839748224 1.0 1.0 98 Q9UL46,Q16543,P62258,P31751,P02545,Q9NR28,P49354,Q99436,Q13813,Q06323,P41440,P28074,P35611,P20700,P28072,P08670,P60900,P49721,P49720,O75832,O00231,P28070 22
Regulation of innate immune responses to cytosolic dna 0.6267488947889999 0.4078954732132392 0.6833504163030213 1.0 1.0 3 Q9UJV9 1
Mecp2 regulates neuronal receptors and channels 0.4056117349069059 0.4060532375985564 0.6847034838996091 1.0 1.0 7 P18031,Q96ST3,Q92769 3
Cellular response to chemical stress 0.2759896093140276 0.4043591132539722 0.6859486619369599 1.0 1.0 71 P28074,P30519,P28072,P33527,Q96ST3,O00231,P28070,P49721 8
Rhog gtpase cycle 0.3052429587287575 0.4013567433604758 0.6881574920590008 1.0 1.0 33 O15173,Q9Y2U8,P02786,Q86XL3,Q86UP2,P42166,O75489 7
Constitutive signaling by akt1 e17k in cancer 0.4212325937359888 0.3999126203126771 0.6892208765634309 1.0 1.0 6 P31751 1
Glycogen breakdown glycogenolysis 0.4209043886856706 0.3986677791328916 0.6901380123108913 1.0 1.0 6 P10253 1
Inla mediated entry of listeria monocytogenes into host cells 0.5987008300252542 0.3973657389241132 0.6910977765041659 1.0 1.0 2 O60716 1
Signaling by receptor tyrosine kinases 0.2631864471350625 0.396512592848977 0.6917269198041225 1.0 1.0 104 Q9UQB8,P41240,Q96ST3,Q16543,Q9UNE7,Q92769,Q9Y487,P31751,Q01085,Q96S59,Q93050,P36543,P31943,P52597,O43865,Q9UI12,P62993,P04792,Q92783,Q8WX92,P16949,Q9Y5K8,Q14155,O75116,P09496,P20936 26
Vesicle mediated transport 0.2821290307952771 0.3951639836570084 0.6927218710336787 1.0 1.0 215 Q8WTV0,P24390,Q9Y496,O75976,O75935,Q9UIQ6,P20339,Q96A65,P31751,Q96KP1,Q9Y3P9,Q14C86,Q9H0B6,Q14108,P53365,P20645,P68371,Q07866,Q8NC96,Q9P2W9,Q9UL25,Q92783,P55327,Q9NSK0,Q6NUQ1,Q14789,Q9H0H5,Q9H3P7,Q7L5N1,P11717,O00461,P49815,Q99627,Q9NVZ3 34
Mapk6 mapk4 signaling 0.2929700361364995 0.3902058432062888 0.6963843411747408 1.0 1.0 48 P28074,P28070,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P04792,Q06323,P49721 11
Dna strand elongation 0.3024491756032214 0.3898250307095906 0.6966659333229281 1.0 1.0 29 Q14566,Q14691,P18858,P49642,P41440 5
G alpha i signalling events 0.3188072160870848 0.3890086621060428 0.6972697386601783 1.0 1.0 20 P63218,P07602,P10644,P04899 4
Reduction of cytosolic ca levels 0.6167754153727392 0.3803725602122623 0.7036688803972924 1.0 1.0 3 P16615 1
Platelet calcium homeostasis 0.6167754153727392 0.3803725602122623 0.7036688803972924 1.0 1.0 3 P16615 1
Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.4143171756387697 0.3739462610615529 0.7084442977493042 1.0 1.0 6 Q96DE5,Q9UJX3 2
Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.4143171756387697 0.3739462610615529 0.7084442977493042 1.0 1.0 6 Q96DE5,Q9UJX3 2
O linked glycosylation of mucins 0.613718411552342 0.3721049807282383 0.7098146881068792 1.0 1.0 3 Q10472,O43505 2
O linked glycosylation 0.613718411552342 0.3721049807282383 0.7098146881068792 1.0 1.0 3 Q10472,O43505 2
Degradation of gli1 by the proteasome 0.2979486599735557 0.3711291334845098 0.7105413527309365 1.0 1.0 41 P28074,P28072,Q9UL46,P49720,Q99436,O00231,P60900,P28070,Q06323,P49721 10
Rhoh gtpase cycle 0.3279342241653228 0.3711133361547557 0.7105531183787652 1.0 1.0 15 P02786,Q9UNZ2,O75116 3
Signaling by alk in cancer 0.3010851742166066 0.3698547603328889 0.7114907108940829 1.0 1.0 33 P33176,O94979,P49589,P19174,P10644,P49792,O43815,Q9P2E9,P67936,P06753,Q8IWJ2,Q9HC35,P06748,Q14203,Q86WB0,P62993,Q07866,P12270 18
Tp53 regulates transcription of genes involved in cytochrome c release 0.5885961746661775 0.3678934026850911 0.7129527196872276 1.0 1.0 2 Q07812 1
Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0.5846264886322546 0.3566204804362187 0.7213759431609015 1.0 1.0 2 P06493 1
Epha mediated growth cone collapse 0.4516793660010446 0.3548517470412773 0.7227006592134875 1.0 1.0 5 P60660,O75116 2
Sema4d induced cell migration and growth cone collapse 0.4516793660010446 0.3548517470412773 0.7227006592134875 1.0 1.0 5 P60660,O75116 2
Intracellular signaling by second messengers 0.272048335894076 0.3539910394978176 0.7233455984686445 1.0 1.0 79 Q9UL46,Q9UNE7,Q92769,P10644,P31751,O43815,Q9Y2Q5,Q99436,O00487,Q06323,P28074,O43865,O15111,P28072,P62993,P60900,P49721,P20618,P49720,O75832,O00231,P49815,P28070,P19174 24
Golgi associated vesicle biogenesis 0.296117982807655 0.3503852096805375 0.726049624714924 1.0 1.0 28 P55327,P02786,Q14789,P11717,Q9H3P7,O75976,O43493,Q9Y5X3,P09496,Q8NC96 10
Ripk1 mediated regulated necrosis 0.3664687346345015 0.3500610215385367 0.7262929026512464 1.0 1.0 10 P41440,O15294,Q9UNE7,Q16543 4
Formation of tubulin folding intermediates by cct tric 0.3363358095707448 0.347219973340966 0.7284260666467137 1.0 1.0 13 P78371,P04350,P49368,Q13885,P68371 5
Regulated necrosis 0.3185804376295397 0.3442881203852867 0.7306296173883471 1.0 1.0 17 P42574,Q16543,Q07812,O15294,Q9UNE7,P41440 6
Apoptosis 0.2694106269039035 0.3417014683390036 0.7325755669806489 1.0 1.0 87 Q9UL46,P62258,P31751,P02545,Q9NR28,P49354,Q99436,Q13813,Q06323,P28074,P35611,P20700,P28072,P08670,P60900,P49721,P49720,O75832,O00231,P28070 20
Interferon alpha beta signaling 0.3637364325488729 0.3381691454932917 0.7352357259012208 1.0 1.0 10 P10321 1
Neurotransmitter receptors and postsynaptic signal transmission 0.296593520191637 0.3371301505155801 0.7360187896607115 1.0 1.0 35 P10644,P04899,Q14155,P63218,Q9Y639,P07196,P68371,P35609 8
Cytosolic sulfonation of small molecules 0.4040625391711843 0.336508958939841 0.7364870968447699 1.0 1.0 6 Q06520 1
Rhobtb3 atpase cycle 0.5997954811024602 0.3354963626638275 0.7372506880675835 1.0 1.0 3 O60664 1
Neddylation 0.2690252045177809 0.3333421098201032 0.7388760561754069 1.0 1.0 67 P28074,Q9Y5A7,P61201,P20618,O75832,Q7L5N1,P28072,Q9UL46,Q9BT78,P49720,Q99436,O00231,O00487,P60900,P28070,Q99627,Q06323,P49721 18
Telomere c strand synthesis initiation 0.4426407515992336 0.3257359959626541 0.7446241074219526 1.0 1.0 5 P49642 1
Interleukin 12 signaling 0.297118859495102 0.3235464663194317 0.7462814231299277 1.0 1.0 26 P20700,P78417,P52597,O00170,Q9UL46,Q13126 6
Fceri mediated ca 2 mobilization 0.516473648851858 0.315151956988536 0.7526462809385752 1.0 1.0 4 P62993,O43865 2
Class i peroxisomal membrane protein import 0.3966364974094973 0.3102497701518183 0.756371025322389 1.0 1.0 6 Q8NBU5 1
Protein folding 0.2921521303470982 0.3082166954217136 0.7579174493521856 1.0 1.0 37 O95302,P61758,O15212,P04350,P49368,Q13885,Q9BUR4,P63218,Q9UHV9,Q99471,P68371,O75347 12
Acyl chain remodelling of pg 0.5665824612053323 0.3076596387454007 0.7583413345530252 1.0 1.0 2 Q8NF37 1
Mtor signalling 0.3139563859188365 0.3063442230006729 0.7593425715781339 1.0 1.0 16 P31751,P49815,Q9Y2Q5 3
C type lectin receptors clrs 0.2783100252930574 0.298927868313675 0.7649950829206924 1.0 1.0 51 P28074,O95999,O75832,O43865,O15111,P28072,Q9UL46,P49720,Q99436,O00231,O00487,P60900,P28070,Q06323,P49721 15
Trans golgi network vesicle budding 0.2913493753256401 0.2976610831418829 0.765961848841433 1.0 1.0 35 P55327,P54920,P51809,O00203,P02786,Q14789,P11717,Q92538,Q9H3P7,O75976,O43493,P20645,Q9Y5X3,P09496,Q8NC96 15
Acyl chain remodelling of pc 0.5611692529772556 0.2937276638926427 0.7689660135537326 1.0 1.0 2 Q8NF37 1
Intra golgi traffic 0.358340935336572 0.2809953923398668 0.7787139338973605 1.0 1.0 9 O00461,P83436 2
Biological oxidations 0.2860122971247161 0.2803670047300251 0.7791959487141413 1.0 1.0 43 Q06520,Q9NX62,O43169,P07099,Q16850 5
Transmission across chemical synapses 0.2869565125174669 0.2801018485671334 0.7793993665003072 1.0 1.0 41 P10644,P04899,Q14155,P63218,Q9Y639,P07196,P68371,P35609,P21964 9
Intrinsic pathway for apoptosis 0.2993422301990903 0.2795864433390079 0.779794809124903 1.0 1.0 21 P27348,P31946,P42574,P31751,Q9NR28,Q04917,P62258,Q07812,P61981 9
Dap12 signaling 0.5767301034279212 0.27885257115115 0.7803579679777051 1.0 1.0 3 P62993 1
Transcription coupled nucleotide excision repair tc ner 0.2864523391736458 0.2729597866307915 0.784884127718777 1.0 1.0 39 Q7L5N1,P18887,Q9NR33,P18858,Q9BT78,Q99627,P41440 7
Condensation of prophase chromosomes 0.3481250208357611 0.2726358191666316 0.7851331749131563 1.0 1.0 10 Q01105 1
Global genome nucleotide excision repair gg ner 0.2879012930998744 0.2722927661827497 0.7853969179159166 1.0 1.0 34 Q7L5N1,P18887,Q9NR33,P18858,Q99627,P41440 6
Golgi to er retrograde transport 0.2635628204106879 0.2716283690626124 0.7859077839534423 1.0 1.0 67 P24390,P35606,Q9Y496,O75935,Q9UJW0,O00139,P48444,Q10472,Q9Y6G9,Q9H0B6,Q14807,P68371,Q07866,O95235,Q13885,Q9P2W9,P54920,Q9NSK0,O14579,Q6NUQ1,P52732,Q9H0H5 22
Processing of smdt1 0.3476371744736253 0.2706581076578808 0.7866539997334843 1.0 1.0 10 Q96TA2,Q10713,Q9UJZ1 3
Regulation of tp53 activity through methylation 0.4176300578034737 0.2503842938484167 0.8022901745596345 1.0 1.0 5 O14744,Q96KQ7,P04637,Q9H9B1 4
Slc transporter disorders 0.2828448060699485 0.2445324246781184 0.8068184927701072 1.0 1.0 31 P35658,P57740,P37198,P52948,Q7Z3B4,Q9BTX1,Q8NFH5,P35613,Q99567,Q9BVL2,Q8N1F7,P53985,P08195,Q8NFH4,P12270 15
Activation of nmda receptors and postsynaptic events 0.2887334766912717 0.2351646267870775 0.8140809598932917 1.0 1.0 23 P10644,Q14155,P07196,P68371,P35609 5
Caspase mediated cleavage of cytoskeletal proteins 0.3583017033775476 0.2289486700260357 0.8189088118392738 1.0 1.0 7 P08670,P35611,Q13813 3
Dna damage recognition in gg ner 0.3011836509955674 0.2278563311852543 0.8197579323758672 1.0 1.0 14 Q99627,Q7L5N1 2
Post chaperonin tubulin folding pathway 0.3358519982948756 0.2242814668387587 0.8225382962216685 1.0 1.0 10 P68371,Q13885,O75347 3
Unfolded protein response upr 0.2791617931664782 0.2169398782341761 0.8282551992308385 1.0 1.0 39 P02545,P51858,Q9NWM8,P43307 4
Transcriptional regulation by ventx 0.3167276586600681 0.2137922842792705 0.8307090421064096 1.0 1.0 12 Q96DE5,Q9UJX3 2
Diseases of mitotic cell cycle 0.3241825659813007 0.2103299772798485 0.8334101400563083 1.0 1.0 11 Q96DE5,P11802,Q9UJX3,Q9UJX2 4
Insulin receptor signalling cascade 0.4016652585105574 0.2066881846747838 0.8362533854235341 1.0 1.0 5 P31751 1
Signaling by braf and raf1 fusions 0.28756120901233 0.2060071981303498 0.8367852886094371 1.0 1.0 20 P51114,O00203,P02545,Q96PU8,Q6WCQ1,P41240,Q9NRY5 7
Interleukin 12 family signaling 0.27479129150494 0.2030553891043086 0.8390917396245419 1.0 1.0 29 P20700,P78417,P52597,O00170,Q9UL46,Q13126 6
Signaling by erbb2 0.3299837396674011 0.2022406463023901 0.8397285984419338 1.0 1.0 10 P31751,P62993,Q9UNE7,Q16543 4
Hiv infection 0.2391754636794623 0.188120177271418 0.8507824442957792 1.0 1.0 122 P18615,Q7Z3B4,O75475,Q9UL46,Q92804,P29083,P52948,Q14241,Q99436,Q8IXH7,O00487,Q06323,P28074,P43487,Q9BTX1,P28072,P18858,Q9UI12,P60900,P49721,P20618,Q8WX92,Q8N1F7,P06748,P49720,O75832,O00231,P28070,P37198 29
Formation of atp by chemiosmotic coupling 0.3243686193946541 0.1818431255173069 0.8557058394301253 1.0 1.0 10 P00846,O75947 2
Degradation of cysteine and homocysteine 0.4595360267308258 0.1772009920045669 0.8593505164882773 1.0 1.0 4 Q96SZ5 1
Slc mediated transmembrane transport 0.285802172832952 0.1724999399210117 0.8630445085883309 1.0 1.0 17 Q8TB61,Q70HW3,Q8TAD4,P53985,P08195,Q15758,P35613,Q99808 8
Aggrephagy 0.286250768649728 0.1684357103494399 0.866240516607899 1.0 1.0 16 Q13885,P61088,Q9Y6G9,P08670,P68371 5
Leishmania infection 0.2725230395659165 0.1637010995171162 0.8699664519363954 1.0 1.0 36 P10644,Q9UQB8,P04899,O43865,O15143,P63218 6
Sumoylation of rna binding proteins 0.2672917224600274 0.1573579336453973 0.874962764454096 1.0 1.0 29 P35658,P57740,P07910,P37198,P61978,P52948,Q7Z3B4,Q9BTX1,Q8NFH5,Q99567,Q9BVL2,Q8N1F7,Q8NFH4,P12270 14
Membrane trafficking 0.2659448540959931 0.1534930765657359 0.878009449713572 1.0 1.0 209 P24390,P35606,P60520,Q9Y496,P83436,O75976,Q9Y5X3,O75935,Q9UJW0,P62258,O60763,Q9UIQ6,O00139,P20339,P48444,Q96A65,Q10472,P31751,Q96KP1,P54619,Q9Y6G9,Q9Y3P9,Q14C86,Q14807,Q14108,Q9H0B6,P53365,O95235,P20645,P68371,P61201,Q07866,Q8NC96,Q13813,Q15286,Q14247,Q9P2W9,Q13885,Q9UL25,P62993,Q9UID3,Q92783,P55327,P54920,O14579,Q6NUQ1,Q9NSK0,O60664,P02786,Q14789,P52732,Q9H0H5,Q9H3P7,Q7L5N1,P11717,O00461,Q9BT78,O43493,P49815,P09496,Q99627,P61981,Q9NVZ3 63
Irs mediated signalling 0.511828401091412 0.1494312223593291 0.8812133764247001 1.0 1.0 3 P31751 1
Dna damage reversal 0.4431252541509851 0.1448182760992656 0.8848543521015753 1.0 1.0 4 Q9H1I8,Q9C0B1 2
Apc cdc20 mediated degradation of nek2a 0.3312208982849295 0.1442384106433437 0.8853122107537159 1.0 1.0 7 Q96DE5,Q9UJX3 2
Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.3312208982849295 0.1442384106433437 0.8853122107537159 1.0 1.0 7 Q96DE5,Q9UJX3 2
Pi3k akt signaling in cancer 0.2988051743087995 0.144186558010898 0.8853531551816365 1.0 1.0 12 P31751,P49815,P62993,O43815 4
Signaling by wnt in cancer 0.3279103398409144 0.1348544686015984 0.8927269394049975 1.0 1.0 7 P30153,Q13363,P30154,P56545,P48729,P35222 6
Glycogen metabolism 0.3155435831467261 0.1296832261743125 0.8968170540614331 1.0 1.0 9 P46976,P10253 2
Ns1 mediated effects on host pathways 0.2643578545721152 0.1223053799656089 0.902657171392134 1.0 1.0 32 P35658,P57740,P37198,O00505,P52294,P52948,Q7Z3B4,Q9BTX1,Q8NFH5,Q86U42,Q99567,Q9BVL2,Q14974,Q8N1F7,Q8NFH4,P12270 16
Inflammasomes 0.4935018050541458 0.1214155309629497 0.9033619159570904 1.0 1.0 3 Q9Y2Z0,P09601 2
Purinergic signaling in leishmaniasis infection 0.4935018050541458 0.1214155309629497 0.9033619159570904 1.0 1.0 3 Q9Y2Z0,P09601 2
The nlrp3 inflammasome 0.4935018050541458 0.1214155309629497 0.9033619159570904 1.0 1.0 3 Q9Y2Z0,P09601 2
Translation of replicase and assembly of the replication transcription complex 0.4731143991338798 0.1208391227686776 0.9038184616547272 1.0 1.0 2 O43633 1
Amino acids regulate mtorc1 0.291582097166025 0.1185549455083305 0.905627961794881 1.0 1.0 12 Q9Y5K8,Q9Y2Q5,Q9UI12,Q8NFG4,P36543 5
Host interactions of hiv factors 0.248608621414884 0.1097517123176244 0.9126062875943116 1.0 1.0 92 Q7Z3B4,O75475,Q9UL46,P52948,Q99436,O00487,Q06323,P28074,P43487,Q9BTX1,P28072,Q9UI12,P60900,P49721,P20618,Q8N1F7,P06748,P49720,O75832,O00231,P28070,P37198 22
Formation of tc ner pre incision complex 0.2665938905180876 0.1092916206964325 0.9129711924999272 1.0 1.0 22 Q99627,Q9BT78,Q7L5N1 3
Rhod gtpase cycle 0.2623292228694767 0.1073074206712932 0.914545097692977 1.0 1.0 25 O15173,Q9H0H5,P20700,P12814 4
Basigin interactions 0.3569154048209114 0.1047674270642902 0.9165603572066924 1.0 1.0 5 P53985,P08195 2
Interleukin 23 signaling 0.4601226993864932 0.1040613460284261 0.917120665668834 1.0 1.0 2 P07237 1
Rhobtb2 gtpase cycle 0.267687215766099 0.1025491578993269 0.918320796119262 1.0 1.0 19 P62995,P78371,Q9NYL9,P12814,Q12792,Q16543 6
Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain 0.4561530133525683 0.0993611933202829 0.9208514934881112 1.0 1.0 2 P04637 1
Interactions of vpr with host cellular proteins 0.2610862243356482 0.0983033569972011 0.9216914125969906 1.0 1.0 33 Q9BTX1,Q7Z3B4,P52948,Q99567,O75475,Q8N1F7,P37198 7
Dissolution of fibrin clot 0.4760296217846083 0.098217811049924 0.9217593396719412 1.0 1.0 3 P60903 1
Cristae formation 0.2642751242152404 0.0900333445096514 0.9282607173326124 1.0 1.0 20 Q13505,Q9NX63,P56385,O75947,P00846 5
Lipophagy 0.4664392856621071 0.0869081439373098 0.9307445260906106 1.0 1.0 3 O60664 1
Synthesis of bile acids and bile salts 0.3972553268327892 0.0728869707198109 0.9418960622243792 1.0 1.0 4 P51659,P22059,Q96SU4 3
Bile acid and bile salt metabolism 0.3972553268327892 0.0728869707198109 0.9418960622243792 1.0 1.0 4 P51659,P22059,Q96SU4 3
Pyroptosis 0.3033261026753301 0.0722754212636775 0.942382724520518 1.0 1.0 7 P09429,O43633,P04637,Q8WUX9,Q07812,P42574 6
Glycogen synthesis 0.3378828711358288 0.0711462157384961 0.9432813864959432 1.0 1.0 5 P46976 1
Noncanonical activation of notch3 0.4103211836881894 0.0583071743747254 0.9535039529150542 1.0 1.0 2 Q92542 1
Beta catenin phosphorylation cascade 0.3276734104046344 0.0555194136097146 0.9557246639785412 1.0 1.0 5 P35222,P30153,P30154,P48729 4
Disassembly of the destruction complex and recruitment of axin to the membrane 0.3276734104046344 0.0555194136097146 0.9557246639785412 1.0 1.0 5 P35222,P30153,P30154,P48729 4
Signaling by ctnnb1 phospho site mutants 0.3276734104046344 0.0555194136097146 0.9557246639785412 1.0 1.0 5 P35222,P30153,P30154,P48729 4
Enos activation 0.38136511375948 0.0542239905747883 0.9567567070844748 1.0 1.0 4 P31749,O75608,P07900 3
Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.381365113759478 0.0542239905747866 0.9567567070844762 1.0 1.0 4 P00374,P31749,P07900 3
Zbp1 dai mediated induction of type i ifns 0.4315029347081104 0.053743926958151 0.9571391847013802 1.0 1.0 3 O15111 1
Rip mediated nfkb activation via zbp1 0.4315029347081104 0.053743926958151 0.9571391847013802 1.0 1.0 3 O15111 1
Cd28 co stimulation 0.2948653345518491 0.0537146633120696 0.9571625000346952 1.0 1.0 7 P31751 1
Regulation of tp53 expression and degradation 0.2709547041558267 0.0536279703541266 0.9572315714517527 1.0 1.0 12 P31751,P30154,P06493 3
Flt3 signaling in disease 0.3737002934803192 0.0463089620675939 0.9630639962773024 1.0 1.0 4 Q14789 1
Repression of wnt target genes 0.4212996389891635 0.0462610475224556 0.9631021856246348 1.0 1.0 3 Q13547,P56545 2
Gab1 signalosome 0.3722400359900827 0.0448786809214866 0.9642040098801212 1.0 1.0 4 P62993 1
Lysosome vesicle biogenesis 0.2613455688774162 0.0442469255742834 0.9647075774579954 1.0 1.0 13 P15586,P51809,Q10567,P20645,P09496 5
Cohesin loading onto chromatin 0.2886805269612727 0.044097174243388 0.9648269452225412 1.0 1.0 8 Q9Y6X3 1
Map2k and mapk activation 0.2729753009319262 0.0438222487131075 0.9650460922095224 1.0 1.0 11 Q9Y2Q5 1
Hsf1 activation 0.2538597115494149 0.0400561562075341 0.9680483560042624 1.0 1.0 15 O75190,P62258,P04792 3
P130cas linkage to mapk signaling for integrins 0.3720678455431153 0.0394495136397843 0.9685320044326924 1.0 1.0 2 P46108 1
Notch3 activation and transmission of signal to the nucleus 0.4104693140794152 0.0393006449246101 0.9686506924395788 1.0 1.0 3 Q92542,Q9Y6A5 2
Trafficking and processing of endosomal tlr 0.3680981595091955 0.038107353669613 0.9696020881899352 1.0 1.0 2 P07858 1
Defects in cobalamin b12 metabolism 0.3478888487910421 0.0326697226576505 0.9739379688159931 1.0 1.0 2 Q96EY8 1
Response of eif2ak1 hri to heme deficiency 0.3981949458483698 0.0325449303287832 0.9740374857692832 1.0 1.0 3 P08243,P20042 2
Vitamin b5 pantothenate metabolism 0.3560852293246615 0.0306473512155953 0.9755507790585736 1.0 1.0 4 Q9NRN7,Q13057,Q9NVE7 3
Pp2a mediated dephosphorylation of key metabolic factors 0.3912141432773387 0.0291992181354727 0.9767057048065886 1.0 1.0 3 P30154 1
Ncam signaling for neurite out growth 0.2849794104240208 0.0265853190953123 0.9787904827868286 1.0 1.0 6 Q13813 1
Ticam1 rip1 mediated ikk complex recruitment 0.3748849875035659 0.0226394147881458 0.9819379034219397 1.0 1.0 3 O15111 1
Irak1 recruits ikk complex 0.3748849875035659 0.0226394147881458 0.9819379034219397 1.0 1.0 3 O15111 1
Ikk complex recruitment mediated by rip1 0.3748849875035659 0.0226394147881458 0.9819379034219397 1.0 1.0 3 O15111 1
Mhc class ii antigen presentation 0.2451353713175414 0.0222882550697642 0.9822180176530912 1.0 1.0 52 P33176,Q9Y496,O75935,Q9UJW0,O00139,P47756,Q9Y6G9,Q9H0B6,Q14807,P68371,Q07866,P10619,O95235,P04350,Q13885,Q9NSK0,P52732,Q9H0H5,P09496 19
Sialic acid metabolism 0.2974415682353533 0.0186895057612317 0.9850887999835902 1.0 1.0 5 P16278,Q9NR45,P10619 3
Signaling by notch1 pest domain mutants in cancer 0.2785716209908634 0.0173864956558492 0.9861282824340376 1.0 1.0 6 Q92542,Q92769 2
Attenuation phase 0.2567091075203146 0.0162401673771185 0.9870427907497314 1.0 1.0 12 O75190,P04792 2
Signaling by notch3 0.2893786127167663 0.0111021836653916 0.991141921034788 1.0 1.0 5 Q13573,P67809,Q92542,Q9Y6A5 4
Response of mtb to phagocytosis 0.2537371724171504 0.0092191582074493 0.992644280200124 1.0 1.0 12 P23246,P20339 2
Infection with mycobacterium tuberculosis 0.2537371724171504 0.0092191582074493 0.992644280200124 1.0 1.0 12 P23246,P20339 2
Interaction between l1 and ankyrins 0.3174052445800432 0.0071250754736062 0.9943150603860328 1.0 1.0 4 Q13813,Q01082 2
Methylation 0.2693640047316032 0.0070676764594683 0.994360857020072 1.0 1.0 7 P21964,P78417 2
Generation of second messenger molecules 0.2552346570397041 0.0066921624697341 0.994660466742245 1.0 1.0 3 P16333,P19174 2
Met activates ras signaling 0.3146185915024103 0.005923989801131 0.9952733676451412 1.0 1.0 4 P62993 1
Mitotic spindle checkpoint 0.2477396513560285 0.0002546628684204 0.9997968084312738 1.0 1.0 45 Q8NBT2,O00139,P30154,P52948,Q9BZD4,Q9Y6G9,Q9UJX3,Q9UJX2,Q96DE5,Q8NFH4,Q53HL2,Q16763,Q2NKX8,P53350 14
Resolution of abasic sites ap sites 0.2397340948704494 7.136799001519871e-05 0.9999430565826796 1.0 1.0 24 P18887,P18858,P41440 3