File size: 54,173 Bytes
5ffb4e8 | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 | Term es nes pval sidak fdr geneset_size leading_edge leading_edge_size
Neutrophil degranulation 0.6193555322517424 3.907893112201576 9.3104476775574e-05 0.115404061091935 0.0046643048656144 144 O00584,P06280,P61916,Q9BTY2,P10253,P17900,P11717,P16278,P15586,Q99519,P11279,P07686,P10619,Q92820,Q92542,Q13510,P10321,P08236,P67870 19
Innate immune system 0.5672198775061972 3.4772296433077035 0.0005066236948432 0.4869553901441542 0.0104253657204457 229 P05067,O00584,P06280,Q8IV08,Q99538,P61916,Q8TBC4,Q9BTY2,P10253,P17900,Q93050,P11717,P16278,P15586,Q99519,P11279,P60900,P07686,P10619,Q9Y487,Q92820,Q92542,Q13510,P30519,P49721,P10321,Q9UQB8,P01889,O15143,P08236,P28072,O95721,P67870,P49427,P42785,P84095,P17858,Q7Z6Z7 38
Diseases of metabolism 0.7601717901019348 3.035914793055447 0.0023980712239823 0.9576612583138098 0.0303638605844384 33 P06865,Q99519,P07686,P10619,P10253,P54802,O43505,P08236,P16278,P15586 10
Sphingolipid metabolism 0.8340087047588362 3.016574548286228 0.0025564834736029 0.9656515979628107 0.0303638605844384 22 P06865,Q99519,P06280,P07686,P10619,P17900,P04062,P16278,Q13510 9
Transport of small molecules 0.5188221228983062 2.878992729557877 0.003989475312083 0.9948287848188836 0.0343407776863619 129 Q9C0H2,P61916,P02786,Q93050,Q658P3,Q8WTV0,Q15904,P60900,Q9Y487,O15118,P51790,Q9H2J7,P38571,P30519,P55011,P49721,P28072,P08195,Q8N4V1,P35613 20
Trans golgi network vesicle budding 0.7410921815117174 2.75887351426685 0.0058000979731454 0.99952914847721 0.047742056441453 28 P05067,P02786,O75976,P11717,P15586 5
Glycosphingolipid metabolism 0.8847874269567346 2.692479380944878 0.0070922920877267 0.9999150823911196 0.0560625206384571 14 P06865,Q99519,P06280,P07686,P10619,P17900,P16278,Q13510 8
Diseases of glycosylation 0.8840407663267004 2.689334571550167 0.007159462281439 0.9999223211179438 0.0560625206384571 14 P06865,Q99519,P07686,P10619,O43505,P16278 6
Cs ds degradation 0.9832721338229296 2.653654598125777 0.0079625286113813 0.9999732405603732 0.0616861775364073 2 P06865 1
Glycosaminoglycan metabolism 0.9165418351228596 2.6259989946954714 0.0086395072551419 0.9999891100166672 0.0660933145113412 11 P06865,P07686,P54802,O43505,P08236,P16278,P15586 7
Nrif signals cell death from the nucleus 0.974296205630355 2.61690222796692 0.008873175315931 0.9999920164427633 0.0671607579947192 2 Q92542 1
Plasma lipoprotein assembly remodeling and clearance 0.8981958355939018 2.613699473719044 0.0089567782230919 0.999992855887156 0.0674061538274976 12 Q8WTV0,P61916,O15118 3
Cargo recognition for clathrin mediated endocytosis 0.7369752859354463 2.5822788522136984 0.0098150244032213 0.9999977175056686 0.072620152466531 23 Q14108,P11717,Q8NC96,P02786 4
Plasma lipoprotein clearance 0.9186635772467602 2.576388043358673 0.0099838531549092 0.9999981766084414 0.0734566179051143 10 Q8WTV0,P61916,O15118 3
Formation of fibrin clot clotting cascade 0.9547123623011018 2.536210173287817 0.0112059457558419 0.9999996415739631 0.0793453255937844 2 Q07021 1
Intrinsic pathway of fibrin clot formation 0.9547123623011018 2.536210173287817 0.0112059457558419 0.9999996415739631 0.0793453255937844 2 Q07021 1
Metabolism of carbohydrates 0.5326878361872288 2.470426868617285 0.0134951909032903 0.999999983070066 0.0914558997047321 83 P06865,P07686,P10253,P54802,O43505,P08236,P16278,P15586 8
Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.8066556216493433 2.4249248278279167 0.0153115568714572 0.9999999985052336 0.1018450525237838 15 Q9BTY2,P05067,Q06481,O43852 4
Ecm proteoglycans 0.923296613627094 2.4053214150973834 0.016158247296349 0.9999999995185476 0.1060342703184681 2 P05067 1
Metabolism of lipids 0.4752720465029422 2.3995196575013074 0.0164165983433663 0.999999999659326 0.1060342703184681 126 P06280,Q8IV08,Q99538,P17900,P50897,P16278,P06865,Q99519,P07686,P10619,Q13510,P35790,O43772,Q9UBM7,Q14849,Q15392,P04062,O15269,Q14739 19
Ion channel transport 0.6912601882056106 2.3938085202598285 0.0166744512174135 0.9999999997588016 0.1066031662783184 24 P61421,Q9HD20,Q15904,P05026,Q9C0H2,Q9Y487,P54709,P51790,Q93050 9
Synthesis of pe 0.9086087311301536 2.3435190836452153 0.0191027849612508 0.9999999999907072 0.1181144027885791 2 P35790 1
Response to elevated platelet cytosolic ca2 0.678194911001279 2.338471761930298 0.0193627888652754 0.9999999999934458 0.1186083392351987 25 P05067,Q08380,Q06481 3
Diseases of carbohydrate metabolism 0.9135031210481568 2.296392822599005 0.0216534309900513 0.9999999999996988 0.1284575162788181 8 P10253,P54802,P16278,P15586 4
Ldl clearance 0.9024235473880994 2.2543637405123036 0.0241732944199433 0.99999999999999 0.1408682688100236 8 P61916,O15118 2
Iron uptake and transport 0.7259842732529282 2.237072105615798 0.0252816277426344 0.9999999999999978 0.1453969595504346 18 Q15904,Q9Y487,P02786,Q93050,Q658P3 5
Golgi associated vesicle biogenesis 0.6592240538067143 2.2308951831313424 0.0256880728881399 0.9999999999999988 0.1458241034210355 25 Q99523,P51809,P02786,Q8NC96,O75976,P11717 6
Transferrin endocytosis and recycling 0.8131454377709977 2.2066554206656797 0.027338141922002 1.0 0.1532099272820283 11 Q93050,Q15904,P02786,Q658P3 4
Keratan sulfate keratin metabolism 0.9844771241830066 2.190117241878148 0.0285157350936233 1.0 0.1577950551189159 5 P06865,P15586,P16278,O43505 4
Keratan sulfate degradation 0.9840751327072272 2.1740933379332943 0.0296981261955568 1.0 0.1636503439311649 4 P06865,P16278,P15586 3
Receptor mediated mitophagy 0.8616891064871521 2.1435502872005525 0.0320689376873681 1.0 0.1759782955594329 2 P67870 1
Diseases associated with glycosylation precursor biosynthesis 0.8729181343823955 2.1414196668941363 0.0322402103539489 1.0 0.176184054091912 8 Q99519,P16278 2
Mitophagy 0.7934004626708819 2.1240460584606753 0.0336662923794952 1.0 0.1792094486619531 11 Q13501,P67870,Q8IWA4,O96008,Q9NS69,Q8N4H5 6
Hs gag degradation 0.9648979591836732 2.1157358344281443 0.0343672810573909 1.0 0.1796099569546979 3 P54802,P16278 2
Heparan sulfate heparin hs gag metabolism 0.9648979591836732 2.1157358344281443 0.0343672810573909 1.0 0.1796099569546979 3 P54802,P16278 2
Mucopolysaccharidoses 0.9652919559003664 2.1052644049168925 0.0352682987371175 1.0 0.1826581079279256 4 P54802,P16278,P15586 3
Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 0.7500724465608596 2.1039478643315666 0.0353829950881787 1.0 0.1826581079279256 14 Q99519,P16278 2
Tryptophan catabolism 0.8514891880864996 2.099578790991114 0.0357659100903315 1.0 0.1826581079279256 2 P08195 1
Cd28 dependent pi3k akt signaling 0.8510811913504713 2.097816319833804 0.0359213743001767 1.0 0.1826581079279256 2 P31751 1
Synthesis of substrates in n glycan biosythesis 0.7603689882136763 2.090492650881765 0.0365735678760661 1.0 0.1839949419412986 13 Q99519,P16278 2
Amino acid transport across the plasma membrane 0.9558837636311904 2.081848356012594 0.0373563232525964 1.0 0.1863571125896571 3 Q9H2J7 1
Sialic acid metabolism 0.9492976815624994 2.0629188609175837 0.0391203378274847 1.0 0.1915296837130012 5 Q99519,P16278 2
Chondroitin sulfate dermatan sulfate metabolism 0.9497959183673464 2.058901926547481 0.0395036345038768 1.0 0.1919789174967003 3 P06865,P07686 2
Diseases associated with glycosaminoglycan metabolism 0.9497959183673464 2.058901926547481 0.0395036345038768 1.0 0.1919789174967003 3 P06865,P07686 2
Hyaluronan metabolism 0.9466326366024718 2.0364290058251804 0.041707295273476 1.0 0.1997400286369744 4 P06865,P07686 2
Hyaluronan uptake and degradation 0.9466326366024718 2.0364290058251804 0.041707295273476 1.0 0.1997400286369744 4 P06865,P07686 2
Eph ephrin mediated repulsion of cells 0.843420826459577 2.027037547053836 0.0426585729493176 1.0 0.2028207240947701 8 Q15375 1
Toll like receptor cascades 0.6938171154228359 2.02065698039691 0.0433152860325665 1.0 0.2030115007291462 17 P05067 1
Rac3 gtpase cycle 0.6243282267745046 2.015076437642135 0.043896640647939 1.0 0.2050022629490246 24 Q13177,O96013,Q14126,Q9UQB8,P02786,Q9Y2U8,P50402,Q6IAA8,P05556,Q14739 10
Rac2 gtpase cycle 0.6156568402270547 2.011908301480246 0.0442296041551104 1.0 0.2051070023671847 27 Q13177,Q14126,P02786,Q9Y2U8,P50402,Q6IAA8,Q9UH62,P05556,Q14739 9
Extracellular matrix organization 0.6186043094250545 1.981914173733005 0.047488847310356 1.0 0.2138221153381865 24 P05067,Q9Y624,Q92542,P20810,O60568,P35613,P05556,O15460 8
Pink1 prkn mediated mitophagy 0.7830025061498258 1.9807839528421165 0.0476155071568391 1.0 0.2138221153381865 9 Q13501,Q8IWA4,O96008,Q8N4H5 4
Vesicle mediated transport 0.4544964601711099 1.978425852921977 0.0478806856061606 1.0 0.2138221153381865 182 P05067,Q10472,Q9H3P7,Q4KMP7,Q9UIQ6,P02786,Q8NC96,P31751,O75976,Q9BVK6,P11717,Q14108,P15586,Q8WTV0,Q7Z392,Q9UID3,Q9NVZ3,Q99523,O00461,Q9BUF5,Q10471,P24390,Q99747,P27348,P61163,P51809,Q12907,Q9NSK0,P11233,O95721,Q9Y3E7 31
O linked glycosylation 0.9277551020408156 1.9754282823489304 0.0482195658735318 1.0 0.2138221153381865 3 Q10472,O43505 2
O linked glycosylation of mucins 0.9277551020408156 1.9754282823489304 0.0482195658735318 1.0 0.2138221153381865 3 Q10472,O43505 2
Integrin cell surface interactions 0.9236734693877544 1.9599033602562863 0.0500070868020126 1.0 0.2180772626432139 3 Q9Y624,P35613 2
Aryl hydrocarbon receptor signalling 0.9210988223722046 1.9500999010501672 0.0511642130555785 1.0 0.2216554887967002 3 Q15185 1
Lysosome vesicle biogenesis 0.7591399339177225 1.929326274634186 0.0536903698839092 1.0 0.2310791409709429 10 P05067 1
Vitamin d calciferol metabolism 0.9098842878773856 1.9073049569085083 0.0564811086910903 1.0 0.2391820583478006 3 Q99538 1
Rac1 gtpase cycle 0.5840577361942162 1.8791589925162029 0.0602227870660869 1.0 0.2525904795096705 30 Q13177,Q9Y2I1,O96013,Q9UQB8,P02786,Q9Y2U8,P50402,Q6IAA8,P05556,Q14739 10
Membrane trafficking 0.4433188938964474 1.844319643214736 0.0651365704217994 1.0 0.2699564487750818 176 P05067,Q10472,Q9H3P7,Q4KMP7,Q9UIQ6,P02786,Q8NC96,P31751,O75976,Q9BVK6,P11717,Q14108,P15586,Q7Z392,Q9UID3,Q9NVZ3,Q99523,O00461,Q9BUF5,Q10471,P24390,Q99747,P27348,P61163,P51809,Q12907,Q9NSK0,P11233,O95721,Q9Y3E7 30
Clathrin mediated endocytosis 0.5357678828599358 1.8339658247971509 0.0666590673026474 1.0 0.2726397255825675 39 Q14108,P11717,Q8NC96,P02786 4
Insulin receptor recycling 0.745847791030447 1.82682709518901 0.0677257706110441 1.0 0.2744456612146003 9 Q93050,Q15904,Q9Y487 3
Signaling by insulin receptor 0.7235695206199422 1.8254327748471764 0.0679357471766364 1.0 0.2744520829191109 11 Q93050,P31751,Q15904,Q9Y487 4
Cell surface interactions at the vascular wall 0.7318809555171891 1.8137496954064671 0.0697162703734366 1.0 0.2776684557205241 10 P05026,P08195,Q9Y624,Q92896,P35613,P05556 6
Irs mediated signalling 0.7796817625459047 1.78538480182717 0.0741989221290215 1.0 0.2861215091665768 2 P31751 1
Insulin receptor signalling cascade 0.7796817625459047 1.78538480182717 0.0741989221290215 1.0 0.2861215091665768 2 P31751 1
Fceri mediated ca 2 mobilization 0.7796817625459025 1.7853848018271592 0.0741989221290233 1.0 0.2861215091665768 2 O43865 1
Antigen activates b cell receptor bcr leading to generation of second messengers 0.7796817625459025 1.7853848018271592 0.0741989221290233 1.0 0.2861215091665768 2 O43865 1
P75ntr negatively regulates cell cycle via sc1 0.7768257853937219 1.7727359328011207 0.0762724739474052 1.0 0.2907006051161517 2 Q13547 1
Gpcr ligand binding 0.7779344266528601 1.7680343306952395 0.0770551645379522 1.0 0.2917844775855253 8 P05067 1
Endosomal vacuolar pathway 0.8708648709787487 1.7524979592372234 0.0796882204702527 1.0 0.2998553895980652 4 P10321,Q9UIQ6 2
Interleukin 1 signaling 0.5140742435006114 1.746530904717124 0.0807187417347694 1.0 0.3020073376837823 44 Q13501,P05067,P49721,P28072 4
Sumoylation of dna methylation proteins 0.7686658506732016 1.7365402922187594 0.082468346446771 1.0 0.3025370815331405 2 Q8IXK0 1
Selective autophagy 0.5739745234374097 1.7307472215070558 0.0834968589762252 1.0 0.3046131946584174 25 Q13501,P67870,Q9BUF5,Q8IWA4,O96008,Q9NS69,Q8N4H5 7
Signaling by notch3 0.8633274275059692 1.7281179982760662 0.0839670713147842 1.0 0.3054824113855546 3 Q92542 1
Regulation of beta cell development 0.8587515745108246 1.7103846988623417 0.0871947585963108 1.0 0.3119558934915238 3 P31751 1
Metabolism of steroids 0.5404306678728701 1.6950159164165286 0.0900724014557816 1.0 0.3163342739127052 34 Q9UBM7,Q99538,Q14849,Q15392,P04062 5
Synthesis of pc 0.8491238632776557 1.6730095255706448 0.0943254208370683 1.0 0.3197499463796453 3 P35790 1
Intra golgi and retrograde golgi to er traffic 0.4635681092773486 1.6728742215989965 0.0943520595433544 1.0 0.3197499463796453 66 Q10472,P40616,Q9BVK6,P11717,Q9UID3,P49755,O00461,Q9BUF5,Q10471,P24390,Q9UJW0,Q9BW19,Q99747,P48444,P61163,Q14203,Q6NUQ1,Q9NSK0,O95721,Q9Y678,P35606 21
Class a 1 rhodopsin like receptors 0.7998082728182723 1.6699484721811548 0.0949295588720131 1.0 0.3197499463796453 7 P05067 1
Peptide ligand binding receptors 0.7998082728182723 1.6699484721811548 0.0949295588720131 1.0 0.3197499463796453 7 P05067 1
Stimuli sensing channels 0.8444272675273816 1.659259758651045 0.0970634604296938 1.0 0.3261035137395581 6 Q9C0H2 1
Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0.8394076741645097 1.6555469595637844 0.0978135990717121 1.0 0.3277875571945163 5 P10321,Q92692,P05556 3
Rhoc gtpase cycle 0.5614102220426981 1.6440681731379134 0.1001621212516854 1.0 0.3322758531195711 24 O75955,Q9UDY2,Q12802,Q07021,Q9NQW6,P02786,P28288,Q9H2G2,Q14739 9
Translocation of slc2a4 glut4 to the plasma membrane 0.5564406423514573 1.636742247059933 0.1016843375683136 1.0 0.3339607794949353 26 P68371,P35579,Q9UPT5,Q9UIQ6,P61981,P11233,Q9BUF5,P31751,O60343,P27348 10
Activation of rac1 0.8390807686877467 1.6315220870035134 0.1027802032610054 1.0 0.335884684106065 4 O94813,Q13177 2
Cd209 dc sign signaling 0.7417380660954751 1.6165597106334637 0.1059733545992616 1.0 0.3437608571606589 2 Q13177 1
Runx1 regulates expression of components of tight junctions 0.7384740922072635 1.6019671575851897 0.1091628722075155 1.0 0.3470111206628336 2 Q16625 1
Ctla4 inhibitory signaling 0.8275658536063615 1.5890324817840085 0.1120530595839928 1.0 0.3538487431827007 3 Q14738 1
Diseases of dna repair 0.6884619534749946 1.5843738669213054 0.1131086652594448 1.0 0.3546078711876552 9 Q9UQ84,P54132 2
Rnd1 gtpase cycle 0.6586362877051556 1.5821063196744112 0.1136253011702281 1.0 0.3546078711876552 12 P02786 1
Translation of replicase and assembly of the replication transcription complex 0.731538147694826 1.570927448188845 0.1161995020840787 1.0 0.3577762581421499 2 Q9Y3E7 1
Cdc42 gtpase cycle 0.5634492803005786 1.5706219324427515 0.1162704923954747 1.0 0.3577762581421499 22 Q13177,Q9UQB8,P02786,A4D1P6,Q6IAA8,Q14739,Q658P3 7
Dap12 interactions 0.820919981097298 1.561996658023156 0.1182887761571862 1.0 0.3622937632535216 4 P10321 1
Cytosolic sulfonation of small molecules 0.7262341901264862 1.5471653030038257 0.1218233903054688 1.0 0.3679393169856813 2 Q8TB61 1
Transport and synthesis of paps 0.7262341901264862 1.5471653030038257 0.1218233903054688 1.0 0.3679393169856813 2 Q8TB61 1
Tyrosine catabolism 0.7258261933904564 1.545336580807595 0.1222648715783043 1.0 0.3679393169856813 2 P16930 1
Transport of bile salts and organic acids metal ions and amine compounds 0.8160623473117283 1.5440785015484548 0.1225693162852401 1.0 0.3679393169856813 3 Q9H2J7 1
Retrograde transport at the trans golgi network 0.6570619604879634 1.5323065878901254 0.125446796191134 1.0 0.3723054944034548 11 Q99747,Q9UID3,P11717,P40616 4
Cell death signalling via nrage nrif and nade 0.7186826346321518 1.528267143313619 0.1264462241703441 1.0 0.3725496134951749 8 Q13501,Q92542 2
Interleukin 1 family signaling 0.484157219072017 1.5243977336545516 0.1274093859103442 1.0 0.3745494670623289 45 Q13501,P05067,P49721,P28072 4
Amyloid fiber formation 0.7890610148286984 1.464738590394309 0.1429922519755662 1.0 0.4041218795103448 5 P05067 1
Downregulation of erbb2 erbb3 signaling 0.703794369645051 1.446435046174884 0.1480552180131455 1.0 0.4100886997681422 2 P31751 1
Synaptic adhesion like molecules 0.7806054465337128 1.432517115142651 0.1519958835144415 1.0 0.4175501302378025 5 Q15334,O75955 2
Rhoq gtpase cycle 0.606791220249124 1.4318656313982925 0.1521822798133221 1.0 0.4175501302378025 14 Q658P3,Q13177,P02786,Q6IAA8 4
Fcgamma receptor fcgr dependent phagocytosis 0.5595862737415002 1.4264355568296876 0.1537426562291211 1.0 0.4194825918270304 19 Q9UQB8,Q8IV08 2
Transport of inorganic cations anions and amino acids oligopeptides 0.7370533380529285 1.4259046727068136 0.1538958604539981 1.0 0.4194825918270304 7 Q9H2J7,P08195 2
Bmal1 clock npas2 activates circadian gene expression 0.6984904120767028 1.422591771263725 0.1548545308037887 1.0 0.4196366606349583 2 P43490 1
Notch hlh transcription pathway 0.7771428571428556 1.3914552157550326 0.1640874309837627 1.0 0.4401286081580765 3 Q13547,Q13573 2
Constitutive signaling by aberrant pi3k in cancer 0.7743657864096294 1.3805442129998189 0.1674191464250771 1.0 0.4472434398414333 3 P84095 1
Fceri mediated mapk activation 0.7725128868422977 1.3732634414457088 0.1696704634528889 1.0 0.4514262633685954 3 Q13177 1
Tp53 regulates transcription of cell death genes 0.7684739548530295 1.3600494310975737 0.1738142819698538 1.0 0.460590360873838 4 Q658P3 1
Basigin interactions 0.7619604909815593 1.3522857465225455 0.1762839223089485 1.0 0.462481923667102 6 P08195,P35613,P05026,P05556 4
Resolution of d loop structures 0.7576830573880381 1.3362515278977516 0.1814670740255815 1.0 0.4673985200868195 6 Q9UQ84,P54132 2
Resolution of d loop structures through synthesis dependent strand annealing sdsa 0.7576830573880381 1.3362515278977516 0.1814670740255815 1.0 0.4673985200868195 6 Q9UQ84,P54132 2
Interferon gamma signaling 0.6269898575362534 1.3195703070558464 0.1869785220139503 1.0 0.4753874777845032 9 P10321,Q12899 2
Cd28 co stimulation 0.7495375767611838 1.305702221061554 0.1916538423850902 1.0 0.4811458586196833 6 Q13177,P31751,P42345 3
Rhoj gtpase cycle 0.5800149232516663 1.3019827456486666 0.1929222840105784 1.0 0.4811458586196833 14 Q658P3,Q13177,P02786,Q6IAA8 4
Defective intrinsic pathway for apoptosis 0.5886375646170527 1.2999228442832256 0.1936274146305483 1.0 0.4811458586196833 13 P05067 1
Reduction of cytosolic ca levels 0.7506169922334871 1.29107753174323 0.196676794206742 1.0 0.4868859736283443 4 P30626,P20020 2
Platelet calcium homeostasis 0.7506169922334871 1.29107753174323 0.196676794206742 1.0 0.4868859736283443 4 P30626,P20020 2
Negative regulation of the pi3k akt network 0.7436947602766746 1.2837793576782444 0.1992191682193189 1.0 0.4922544925794428 6 Q14738,P84095,P31751 3
Signal transduction by l1 0.7481684850277457 1.2816191088068634 0.1999762935663285 1.0 0.4922780908913171 4 P67870 1
Antigen processing cross presentation 0.4492303538901649 1.2715857668618595 0.2035203364673121 1.0 0.4970109987289584 48 P60900,P49721,Q9UIQ6,P10321,P01889,P28072 6
Intra golgi traffic 0.6947218929697194 1.2596261826853634 0.2078042457304403 1.0 0.5011393641616317 7 Q99747,O00461 2
Slc mediated transmembrane transport 0.5521841168816307 1.2589120868841923 0.2080620875801992 1.0 0.5011393641616317 16 P55011,P08195,Q9H2J7,P35613 4
Costimulation by the cd28 family 0.6127288868148325 1.2576380621853065 0.2085226815190388 1.0 0.5011393641616317 9 Q14738,Q13177,P31751,P42345 4
Autophagy 0.4712711888615632 1.2405801989614489 0.2147608705029349 1.0 0.5123914247325457 35 Q13501,Q5MNZ6,P67870,Q9Y3E7,Q9BUF5,Q8IWA4,O96008,Q96HS1,Q6IAA8,Q9NS69,Q8N4H5 11
Rhob gtpase cycle 0.557630344861826 1.2375429906398052 0.2158855642946862 1.0 0.5141433782569651 15 Q14254,Q9UDY2,O75955,Q12802,Q16513,Q9NQW6,P02786,Q9H2G2,O75116 9
P75 ntr receptor mediated signalling 0.5665292067219597 1.2362636132542872 0.216360591755842 1.0 0.5143445836506207 14 Q13501,Q92542,Q12802 3
Regulation of localization of foxo transcription factors 0.7241710082365626 1.2105008958376944 0.2260867472242442 1.0 0.5284582605619521 6 P31751,P27348,P61981 3
Leishmania infection 0.488091926187299 1.2099185629560976 0.2263101434752779 1.0 0.5284582605619521 26 P05067 1
Regulated necrosis 0.5576491985406107 1.1929129162437062 0.2329034801794889 1.0 0.5390753662502407 14 P09429,Q9Y3E7,O75955,Q13546 4
G alpha i signalling events 0.5217415203636655 1.1751303946741898 0.2399425521765574 1.0 0.5448632522640785 18 P05067,Q9ULM6 2
Signaling by fgfr1 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Signaling by fgfr4 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Negative regulation of fgfr3 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Negative regulation of fgfr1 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Signaling by fgfr3 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Spry regulation of fgf signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Negative regulation of fgfr2 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Negative regulation of fgfr4 signaling 0.6434108527131821 1.1750993691453873 0.2399549630320163 1.0 0.5448632522640785 2 P62993 1
Platelet homeostasis 0.7090943068182012 1.1539382871714388 0.2485254707909328 1.0 0.5550129701427986 6 Q14738,P20020,P30626 3
Protein protein interactions at synapses 0.5789769280153582 1.144351143929864 0.2524780409538372 1.0 0.5588463528339557 10 Q15334,Q14254,O75955,Q96HC4 4
Activation of bh3 only proteins 0.5783507175772333 1.141567662038156 0.2536337722157795 1.0 0.5604625469935933 10 Q9Y3B8,P31751,P27348,P61981 4
Signaling by notch1 pest domain mutants in cancer 0.6624018114803002 1.132416003453803 0.2574595798224859 1.0 0.5656454515250204 7 Q92542,Q13573 2
Signaling by notch1 0.6223812054061385 1.1315220020831926 0.2578354482116904 1.0 0.5656454515250204 8 Q13547,Q96J02,Q92542,Q13573 4
Cd28 dependent vav1 pathway 0.7081155184715742 1.127119406865662 0.2596919991501933 1.0 0.5681301708983466 4 Q13177 1
Signaling by type 1 insulin like growth factor 1 receptor igf1r 0.7089795918367321 1.1239276562461626 0.2610437175886784 1.0 0.5701402588130837 3 P31751,P62993 2
Rhog gtpase cycle 0.467006168598017 1.1172857134028271 0.2638721820296066 1.0 0.5743602911143691 30 Q13177,Q14126,P02786,Q9Y2U8,P84095,P50402,Q6IAA8,P05556,Q14739 9
Downregulation of erbb2 signaling 0.6990568122578804 1.116322218870639 0.2642842341801881 1.0 0.5743602911143691 6 Q93034 1
Activation of bad and translocation to mitochondria 0.6164834112812896 1.107148019949322 0.2682299368936447 1.0 0.5800637551542366 8 P31751,P27348,P61981 3
Methionine salvage pathway 0.7019124820254938 1.1032701906741322 0.2699098477575661 1.0 0.5817860384561613 4 Q13126 1
Rhoa gtpase cycle 0.4509054659932376 1.0955457054372248 0.2732776333449322 1.0 0.5871233982304662 35 Q15904,O75955,Q12802,Q9UDY2,Q07021,Q96CS3,Q9NQW6,P02786,P28288,Q9H2G2,Q14739,P30519 12
Mhc class ii antigen presentation 0.4302104799424325 1.088060095252016 0.2765685786317262 1.0 0.5871527196268513 43 P10619,Q99538,Q9NSK0,Q9BUF5 4
Glycerophospholipid biosynthesis 0.5056420230909109 1.0880220602982027 0.276585368867744 1.0 0.5871527196268513 18 P35790,Q8IV08 2
Hemostasis 0.3836513768203151 1.06669057901942 0.2861115827055678 1.0 0.5990766145528227 92 P05067,Q14738,Q08380,Q9H4M9,O15439,Q06481,Q13547,P05026,Q9BUF5,P54709,Q8IWA4,Q92896,P05556,O43852,Q9Y624,Q9NSK0,Q07021,P08195,P42785,P84095,P35613 21
Ros and rns production in phagocytes 0.6012745663998889 1.0443751406228592 0.2963118604541399 1.0 0.6126259344083238 8 Q93050,Q9Y487 2
Rhoh gtpase cycle 0.5021258682997802 1.0330456020135432 0.3015825584613325 1.0 0.619747562961597 17 Q13177,Q9BZH6,P02786,Q6IAA8 4
Rho gtpases activate ktn1 0.5963659972982689 1.0241513777291738 0.305763780347779 1.0 0.6243269747566279 8 Q9NSK0 1
Death receptor signalling 0.4999353993714289 1.0214827588060136 0.3070257735338897 1.0 0.6259333494491219 17 Q13501,Q92542,Q12802 3
Sphingolipid de novo biosynthesis 0.5942510345616491 1.0154444121527428 0.3098940316234408 1.0 0.6308043889460149 8 O15269 1
Rho gtpases activate paks 0.5533733797200457 0.999596196738604 0.3175059644533977 1.0 0.6413425693023387 9 Q13177,Q14247,P35579 3
Dna damage reversal 0.6030191758465964 0.9954150852144652 0.3195344247240415 1.0 0.6444515120391464 2 Q6P6C2 1
Pyroptosis 0.6688444262964377 0.9768405396198608 0.3286481025875338 1.0 0.6598011449813751 4 P09429,Q9Y3E7,Q8WUX9 3
Fcgr3a mediated il10 synthesis 0.6647721271054721 0.961379943579992 0.3363611649895317 1.0 0.6663395928957575 4 O43865 1
Diseases of programmed cell death 0.4673455199538709 0.9554829418781692 0.3393335276638516 1.0 0.6680153302440845 20 P05067 1
Hdms demethylate histones 0.6550171919580784 0.9539364422019012 0.3401158154793091 1.0 0.6685560134123136 5 Q8NB78 1
Response of eif2ak1 hri to heme deficiency 0.6583803672399746 0.9279159651186684 0.3534511622275811 1.0 0.6845517362554769 3 P20042 1
Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0.6574913347746272 0.9245134034036692 0.3552190762826304 1.0 0.6864022072353549 3 Q14738 1
Cell cell junction organization 0.6091489939076333 0.9240717144345832 0.3554489789935551 1.0 0.6864022072353549 7 Q9Y624 1
Eph ephrin signaling 0.4485232790816377 0.9200789106138356 0.3575315242007528 1.0 0.6881153516260431 23 Q15375,Q92542 2
Signaling by erbb4 0.6076785177977274 0.9183683251299488 0.3584260677414317 1.0 0.6881153516260431 7 Q92542 1
Hdr through single strand annealing ssa 0.5133051026138619 0.9103373266639296 0.3626446390734785 1.0 0.694190391947342 12 Q9UQ84,P54132 2
Synthesis of active ubiquitin roles of e1 and e2 enzymes 0.5313735687516143 0.904595509323432 0.3656797152546094 1.0 0.6987975706640616 9 P49427 1
Adaptive immune system 0.3648108429447423 0.9024470337068756 0.3668194457684659 1.0 0.6987975706640616 153 Q14738,Q9UIQ6,Q92692,Q99538,Q8TBC4,P55786,P60900,P10619,Q9BUF5,Q16763,P05556,P49721,P10321,P61163,P01889,Q03519,P28072,Q9NSK0,P49427,Q93034,Q7Z6Z7 21
Copi independent golgi to er retrograde traffic 0.4491957012053312 0.8970020043048563 0.3697178475149481 1.0 0.6987975706640616 22 Q10472,P61163,Q14203,Q9BUF5,Q10471,Q9UJW0 6
Ion homeostasis 0.509489868372925 0.8927471301007875 0.3719926050049202 1.0 0.6987975706640616 12 P30626,P05026,P54709,O43865,P17612,P23634,P20020 7
Cardiac conduction 0.509489868372925 0.8927471301007875 0.3719926050049202 1.0 0.6987975706640616 12 P30626,P05026,P54709,O43865,P17612,P23634,P20020 7
Gap junction assembly 0.6485009910936244 0.8902121297474309 0.3733519927399427 1.0 0.6987975706640616 3 Q9BUF5 1
Transport of connexons to the plasma membrane 0.6485009910936244 0.8902121297474309 0.3733519927399427 1.0 0.6987975706640616 3 Q9BUF5 1
Activation of ampk downstream of nmdars 0.6485009910936244 0.8902121297474309 0.3733519927399427 1.0 0.6987975706640616 3 Q9BUF5 1
Platelet activation signaling and aggregation 0.4130632368584504 0.8898601302311517 0.3735409944931658 1.0 0.6987975706640616 38 P05067,Q08380,Q06481 3
Ion transport by p type atpases 0.5203327804824983 0.8847145497590582 0.3763106063494827 1.0 0.7003830529191793 10 P30626,Q9HD20,P05026,P54709,P20020 5
Rnd3 gtpase cycle 0.4866628182214282 0.8820484856845352 0.3777505880201492 1.0 0.7003830529191793 15 Q9NYL9,Q14254,Q9Y2I1,O43396,Q9Y2U8,O75976 6
Ripk1 mediated regulated necrosis 0.5189127773779578 0.8784828867193974 0.3796817207576202 1.0 0.7009283455191953 10 O75955,Q13546 2
Homologous dna pairing and strand exchange 0.4991219157222838 0.8743316465945642 0.3819376698031411 1.0 0.703513162420611 13 Q9UQ84,P54132 2
Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.5581545938877641 0.8677850852067218 0.3855119964610694 1.0 0.7081161776000395 8 P27348,P61981 2
Notch1 intracellular domain regulates transcription 0.6309036946997305 0.8637458089746182 0.3877275429564881 1.0 0.7102046927311473 5 Q13547,Q92769,Q13573 3
Maturation of sars cov 2 nucleoprotein 0.6299902893988537 0.8600740118519474 0.3897482457682231 1.0 0.7119257138373783 6 P48729,Q99873 2
Rnd2 gtpase cycle 0.4780718873747089 0.8393685008949546 0.401262554156107 1.0 0.7261094565159071 15 Q9Y2U8,O43396,P02786 3
Cell junction organization 0.4780323312331601 0.839172392055306 0.4013725773299774 1.0 0.7261094565159071 15 Q9Y624,Q92692 2
Mitochondrial protein import 0.4214507077239925 0.837189383773622 0.4024861238934463 1.0 0.7271251374042096 32 Q99595,O14925,O96008,O60830,Q8N4H5 5
Dcc mediated attractive signaling 0.5646674826601435 0.8286155356660241 0.4073219941711723 1.0 0.7294634926395304 2 P60953 1
Phosphorylation of emi1 0.5638514891880915 0.8251266483999692 0.4092996919613125 1.0 0.7294634926395304 2 P06493 1
Signaling by notch4 0.3967999173279871 0.8190263764417456 0.412771364932528 1.0 0.733630077754574 40 P28072,P49721,Q92542 3
Ire1alpha activates chaperones 0.439316797853644 0.8161223135604108 0.4144301830578856 1.0 0.7355856483655462 21 Q13217,P61421,O14773,Q9NWM8 4
Signaling by tgfb family members 0.4690072306471198 0.7945412337100886 0.4268804142502054 1.0 0.7476083850631923 15 Q13547,Q9Y624,Q13573 3
Sealing of the nuclear envelope ne by escrt iii 0.6115878674222227 0.7932001951723152 0.4276611938324584 1.0 0.747750780879214 6 P68371,Q9Y3E7,Q9BUF5 3
Interleukin 3 interleukin 5 and gm csf signaling 0.6160984402963757 0.7794980557477744 0.4356863824394787 1.0 0.7565516886268692 4 P62993 1
Cholesterol biosynthesis 0.4846329878350934 0.7789517318295746 0.436008148570838 1.0 0.7565516886268692 12 Q15392,Q9UBM7 2
Antigen processing ubiquitination proteasome degradation 0.3621830627835462 0.7634709464142889 0.4451825829164977 1.0 0.7654118298969027 80 P55786,P49721,P60900,Q9UIQ6,P49427,Q8TBC4,Q93034,Q16763,P28072 9
Rho gtpase cycle 0.3425207457545949 0.7567091492561974 0.4492241322183314 1.0 0.7668513395471808 128 Q5JTV8,Q13177,O96013,P02786,O43396,P28288,O75976,Q96AC1,Q658P3,Q9NYL9,Q15904,O75955,Q9NQW6,Q6IAA8,P05556,P30519,Q12802,Q14126,Q9UQB8,Q9Y2U8,Q14739,Q9BZH6,Q9UDY2,Q07021,Q9Y2I1,A4D1P6,P84095,P50402,Q9UH62,Q96CS3 30
Degradation of the extracellular matrix 0.5652072215786408 0.7557137551839147 0.4498208351936124 1.0 0.7668513395471808 7 Q92542 1
Interconversion of nucleotide di and triphosphates 0.4596376400448136 0.7484804101952359 0.4541704368722061 1.0 0.7717967294976716 15 Q9Y3D8,P04818,P15531,Q16881,P17812,P23919,Q9NRF8,P33316,P00568 9
Clec7a dectin 1 signaling 0.3862828335014267 0.7426111498675642 0.4577171360850451 1.0 0.7742146331631242 43 P28072,P49721,P49427,Q8TBC4 4
Interferon alpha beta signaling 0.5232381799915181 0.7277517630988763 0.4667655574171734 1.0 0.7820995408631265 8 P10321 1
Metabolism of cofactors 0.6004987097248595 0.7227335051757422 0.4698436267393715 1.0 0.7852589548423252 4 O75874 1
Phospholipid metabolism 0.4093896434475977 0.7124612016064431 0.4761792287181219 1.0 0.7911503404805158 26 P35790,Q8IV08 2
Pka activation in glucagon signalling 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Pka mediated phosphorylation of creb 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Creb1 phosphorylation through the activation of adenylate cyclase 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Glucagon signaling in metabolic regulation 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Vasopressin regulates renal water homeostasis via aquaporins 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Aquaporin mediated transport 0.5980624275727464 0.7024806887498315 0.4823794407030024 1.0 0.7911503404805158 3 P17612 1
Cell cell communication 0.4156721624484004 0.6809238263961561 0.49591969091643 1.0 0.8023880595202925 21 P62993,Q92692,Q9Y5K6,Q9Y624,Q96AC1,P05556 6
Uch proteinases 0.3758752092661932 0.6635878966356096 0.5069541059162912 1.0 0.8153897048762977 44 P28072,Q8NB78,P49721 3
Signaling by tgf beta receptor complex 0.4453119513623891 0.650119480372544 0.5156150468930236 1.0 0.8215292121788241 14 Q9Y624,Q13573 2
Disassembly of the destruction complex and recruitment of axin to the membrane 0.5696472657848175 0.6421097861290016 0.5208019023004065 1.0 0.8215292121788241 5 Q14738 1
Beta catenin phosphorylation cascade 0.5696472657848175 0.6421097861290016 0.5208019023004065 1.0 0.8215292121788241 5 Q14738 1
Signaling by ctnnb1 phospho site mutants 0.5696472657848175 0.6421097861290016 0.5208019023004065 1.0 0.8215292121788241 5 Q14738 1
Rho gtpases activate cit 0.4675341019609638 0.6360350166115959 0.5247535989554404 1.0 0.8237192965724851 9 Q15334,P35579,O43663 3
Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.3961075849073061 0.6301541714161376 0.5285937200215391 1.0 0.8274373194029568 26 Q15185,P61163,Q14203,Q9BUF5,O60884,P68371,Q9UJW0,Q13409,P25685,P63167 10
Cell extracellular matrix interactions 0.5644720917689279 0.626871556958556 0.5307434330565077 1.0 0.8291685662341882 6 Q96AC1,P05556 2
Neurexins and neuroligins 0.5614538727297671 0.616524348311504 0.5375485071612707 1.0 0.8378122886762053 6 Q15334 1
Signaling by erbb2 0.4622928536010144 0.6147493313280656 0.5387202757216518 1.0 0.8386461029851247 9 Q93034,P31751,P62993,P40818 4
C type lectin receptors clrs 0.3682107905379717 0.6060657535096743 0.5444710909697132 1.0 0.8433735633149262 45 P28072,P49721,P49427,Q8TBC4 4
Golgi to er retrograde transport 0.3618684593412153 0.6018582944416468 0.54726846752742 1.0 0.8433735633149262 55 Q10472,Q9BVK6,P49755,Q9BUF5,Q10471,P24390,Q9UJW0,Q9BW19,Q99747,P48444,P61163,Q14203,Q6NUQ1,O95239,P63167,P61923,Q9NSK0,Q9Y678,P35606,P68371,Q02241 21
Unfolded protein response upr 0.382842487936332 0.5995575093547928 0.5488011721798722 1.0 0.8433735633149262 34 P61421,Q9NQT5,Q14203,O14773,Q9NWM8,Q13217,Q9Y2L1,Q15024,O94979,Q9Y3B2 10
Regulation of tp53 activity through phosphorylation 0.4007220208937532 0.5969118756658509 0.5505662180927038 1.0 0.8441013320585019 21 Q9UQ84,P67870,P54132,P38398 4
Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.5659073318495962 0.5886706502216773 0.5560822300241357 1.0 0.846935389651883 3 P00374 1
Signaling by interleukins 0.3355770245783689 0.5672301175969046 0.5705578484557803 1.0 0.8540931160231309 95 Q13501,P05067,Q13126,P49721,P60900,P11233,P28072,O00170,O14979,P05556 10
Metalloprotease dubs 0.5560316546028055 0.5669773258806637 0.5707295866556799 1.0 0.8540931160231309 4 P38398 1
Class i mhc mediated antigen processing presentation 0.3310367979457791 0.5659018183266878 0.5714605254244367 1.0 0.8540931160231309 100 P55786,P49721,P60900,Q9UIQ6,P10321,P49427,P01889,Q8TBC4,Q93034,Q03519,Q16763,P28072 12
Sars cov 1 infection 0.43932621935069 0.5597351493767926 0.5756601034727769 1.0 0.8557564836641043 11 Q10472 1
Hdr through homologous recombination hrr 0.4007987462651214 0.5555418198473028 0.5785241138093928 1.0 0.8580138039267684 19 Q9UQ84,P35251,P54132,P38398 4
Post chaperonin tubulin folding pathway 0.5406546040010191 0.5464878341428556 0.5847306481880241 1.0 0.8617063348030182 6 P68371,O75347,Q9BUF5 3
Regulation of tp53 activity through methylation 0.4953080375356988 0.5461837899148827 0.5849396076794975 1.0 0.8617063348030182 2 P04637 1
Fceri mediated nf kb activation 0.3607870691045787 0.5452186435439765 0.585603150560825 1.0 0.8617199433392252 40 P28072,P49721,P49427 3
Sulfur amino acid metabolism 0.443352546340672 0.5392358907927975 0.589724098330747 1.0 0.8658490942046754 9 Q13126 1
Signaling by hippo 0.533193845139895 0.5182478508631468 0.6042853526867715 1.0 0.8823102100759181 5 Q9UDY2 1
Processing of dna double strand break ends 0.3786300251390002 0.505910274478412 0.6129196392005676 1.0 0.8882127492203707 23 Q9UQ84,P38398,P54132,Q9UNS1 4
Activation of nima kinases nek9 nek6 nek7 0.5346938775510158 0.4844113238998487 0.6280939834870467 1.0 0.9020717298281792 3 P06493,P53350 2
Suppression of phagosomal maturation 0.5182804634994044 0.4739913301189009 0.6355060897564302 1.0 0.905332687775783 6 Q14974,Q9H267,P52294 3
Regulation of pten stability and activity 0.3534209007968443 0.4710071864464045 0.6376356029658214 1.0 0.905332687775783 39 P28072,P67870,P49721 3
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.4223601501635701 0.4586091268614516 0.6465148813480854 1.0 0.9116275147060262 9 Q9H9A5,Q9ULM6 2
Plasma lipoprotein assembly 0.4679722562219503 0.4458389732085483 0.6557135673565189 1.0 0.919674939519207 2 P17612 1
Ptk6 regulates proteins involved in rna processing 0.4663402692778542 0.4401072991962247 0.6598593955921845 1.0 0.9221916014246846 2 Q07666 1
Dectin 1 mediated noncanonical nf kb signaling 0.3459532591988221 0.4359933546483931 0.6628415510447025 1.0 0.9221916014246846 40 P28072,P49721,Q8TBC4 3
Tnfr2 non canonical nf kb pathway 0.3459532591988221 0.4359933546483931 0.6628415510447025 1.0 0.9221916014246846 40 P28072,P49721,Q8TBC4 3
Semaphorin interactions 0.3879357957159468 0.4344752161042663 0.6639433883569372 1.0 0.9223770490148592 16 P35579,Q13177,P05556,O75116 4
Carboxyterminal post translational modifications of tubulin 0.5132397919037379 0.4287221528872899 0.6681254371121574 1.0 0.9257658129881698 4 Q9BUF5 1
Perk regulates gene expression 0.4055493882696147 0.422995540619596 0.6722985146349465 1.0 0.9290840963003404 11 Q9NQT5,P20042,Q9Y2L1,Q15024,Q9Y3B2 5
Endosomal sorting complex required for transport escrt 0.5091228659148943 0.4161830737394071 0.6772760445105439 1.0 0.9300124682272848 4 Q8WUX9,Q9Y3E7 2
Transcriptional regulation by e2f6 0.5006289608734862 0.4150804376161578 0.6780830195960248 1.0 0.9300124682272848 5 Q13185,P38398 2
Signaling by vegf 0.3764402429584792 0.4116766043142673 0.6805764753082761 1.0 0.9300124682272848 18 O43865,Q9UQB8,P31751,P42345 4
Intrinsic pathway for apoptosis 0.391414352878027 0.4088492081978999 0.6826503252023102 1.0 0.9300124682272848 14 P31751,P27348,Q07021 3
Rap1 signalling 0.5097959183673421 0.4067911110921197 0.6841614158596787 1.0 0.9300124682272848 3 P63104,P17612 2
Signaling by wnt in cancer 0.4629207418179922 0.3962403944438581 0.6919276943695045 1.0 0.9300124682272848 7 Q14738 1
Rho gtpases activate iqgaps 0.4331391276294909 0.394291376070744 0.6933659295619996 1.0 0.9300124682272848 8 Q9BUF5 1
Protein ubiquitination 0.3605325072054683 0.3913794701359968 0.6955167649966902 1.0 0.9300124682272848 22 P49427,Q14527 2
Diseases associated with n glycosylation of proteins 0.4508363933088508 0.3872816517774059 0.6985477075211273 1.0 0.9300124682272848 2 O75340 1
Deactivation of the beta catenin transactivating complex 0.4872293149680959 0.3793508294044574 0.7044273589292942 1.0 0.9300124682272848 6 P31751 1
E2f enabled inhibition of pre replication complex formation 0.4483884128927067 0.3792218548720974 0.7045231236678222 1.0 0.9300124682272848 2 P06493 1
Flt3 signaling 0.4956407372162369 0.3652359906543039 0.7149352545956775 1.0 0.9372295595480504 3 P31751 1
Copi dependent golgi to er retrograde traffic 0.3434776065320875 0.3586841833839368 0.7198313619481116 1.0 0.9414279083273714 36 Q9NSK0,Q9BW19,P49755,Q9Y678,Q9BUF5,Q02241,P24390,P35606,Q6NUQ1,P68371,O95239,Q9BVK6,Q99747,P48444,P61923 15
Translation of sars cov 2 structural proteins 0.3678837998390782 0.356692736261595 0.7213218439483233 1.0 0.942044456107304 17 Q99873 1
Sars cov 2 infection 0.3555764924569494 0.355287278324236 0.7223743850282047 1.0 0.942044456107304 21 Q10472,Q9Y3E7,Q99873 3
Prolactin receptor signaling 0.4406364749081971 0.3542334097143715 0.7231639674445591 1.0 0.942044456107304 2 P63208 1
Fbxw7 mutants and notch1 in cancer 0.4406364749081971 0.3542334097143715 0.7231639674445591 1.0 0.942044456107304 2 P63208 1
Kinesins 0.3801486581397119 0.34788418058062 0.7279271661767894 1.0 0.9432692737339036 13 Q9NSK0,Q9BUF5,P68371,O95239,Q9BW19,Q02241 6
Ksrp khsrp binds and destabilizes mrna 0.3915443586310768 0.3477118355857891 0.7280566071757542 1.0 0.9432692737339036 9 Q9Y2L1,Q15024,Q9Y3B2 3
Mrna decay by 3 to 5 exoribonuclease 0.3816514890574796 0.3421749867233443 0.7322192080333751 1.0 0.9432692737339036 12 Q9NQT5,Q9Y2L1,Q15024,Q96C86,Q9Y3B2 5
Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.4171343925459544 0.3418708969415889 0.7324480523174621 1.0 0.9432692737339036 8 Q9Y2L1,Q15024,Q9Y3B2 3
Intraflagellar transport 0.416891540245649 0.3410965792040028 0.7330308763772893 1.0 0.9432692737339036 8 Q9BW83,P68371,A0AVF1,Q9BUF5 4
Anchoring of the basal body to the plasma membrane 0.3458425608917454 0.3356676088418372 0.7371215343672732 1.0 0.9452668556589084 25 P61981,Q15019,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P68371,P17612,P63167,O94927 12
Atf4 activates genes in response to endoplasmic reticulum stress 0.3843987026933519 0.3235084103495307 0.7463102391537126 1.0 0.9514913697632522 9 Q9NQT5,Q9Y2L1,Q15024,Q9Y3B2 4
Butyrate response factor 1 brf1 binds and destabilizes mrna 0.4383590271322634 0.3215650572878117 0.7477822191010861 1.0 0.9524460179459676 7 Q9Y2L1,Q15024,Q9Y3B2 3
Tcr signaling 0.328769840690661 0.3098889873303587 0.7566453776938324 1.0 0.9587586546322164 43 P28072,P49721,P49427 3
Tp53 regulates transcription of death receptors and ligands 0.4247246022031832 0.3056176442235293 0.7598957847293344 1.0 0.9587586546322164 2 P04637 1
Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0.4247246022031796 0.3056176442235185 0.7598957847293426 1.0 0.9587586546322164 2 O00767 1
Antigen presentation folding assembly and peptide loading of class i mhc 0.3585871108724431 0.3054107426859072 0.7600533409263348 1.0 0.9587586546322164 16 P04439,P10321,Q6P179,P01889,Q03519 5
Phosphorylation of the apc c 0.3786787006535645 0.304594508060018 0.7606750033180554 1.0 0.9587586546322164 9 Q16763 1
Recruitment of mitotic centrosome proteins and complexes 0.3401165079532412 0.3044092907263687 0.7608160904779588 1.0 0.9587586546322164 25 P61981,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P68371,P17612,P63167,O94927 11
Fc epsilon receptor fceri signaling 0.3272433495202826 0.2984832624075517 0.7653343489062983 1.0 0.9598370195639792 44 P28072,P49721,P49427 3
Cooperation of prefoldin and tric cct in actin and tubulin folding 0.3562126969239911 0.2801299674406077 0.7793777940469957 1.0 0.9710885097066162 15 Q99471,Q9UHV9,Q9BUF5 3
Tp53 regulates transcription of cell cycle genes 0.3555967387483976 0.2776989097693554 0.7812434975708378 1.0 0.9724930872408254 15 Q9H9A5,Q9ULM6,Q99873 3
G2 m dna damage checkpoint 0.3353775711544534 0.2733265750156938 0.7846021888930359 1.0 0.9751874777487934 30 Q9UQ84,P54132,P27348,P38398 4
Rho gtpases activate wasps and waves 0.3567549976081624 0.2522902041602397 0.8008167592474731 1.0 0.9866002543769148 12 Q9UQB8 1
Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.3858818213621582 0.2480043096741986 0.8041310723168402 1.0 0.9897575908796996 8 Q16763 1
Recruitment of numa to mitotic centrosomes 0.3294233267228629 0.239924096869886 0.8103890997690602 1.0 0.9937452927335684 28 P61981,Q15154,P61163,Q14203,Q7Z460,Q9BUF5,Q15691,P07437,P68371,P17612,P63167,O94927 12
Collagen biosynthesis and modifying enzymes 0.3528748157011913 0.2342008669282475 0.8148290420218083 1.0 0.9973325728092208 11 O60568,P13674,O15460 3
Apc c cdc20 mediated degradation of cyclin b 0.3803676214370223 0.2327450711167051 0.8159593684334199 1.0 0.9977887541567448 8 Q16763 1
Phenylalanine and tyrosine metabolism 0.4430074359403043 0.2301192329599209 0.8179991201601227 1.0 0.9983610440035248 3 P16930 1
The phototransduction cascade 0.4419716658888233 0.2277983909201143 0.8198029776719193 1.0 0.9983610440035248 3 P49356 1
Regulation of bach1 activity 0.4408163265306078 0.2252260002591238 0.8218034637362872 1.0 0.9993676470366484 3 Q13309,P63208 2
Sema4d in semaphorin signaling 0.4011019866448627 0.2209310912582701 0.825146088200639 1.0 1.0 7 P35579,O75116 2
Signaling by receptor tyrosine kinases 0.3065803800516128 0.2196270456438613 0.8261616262695717 1.0 1.0 81 Q13547,Q14738,Q15904,P11233,Q9UQB8,Q9Y487,Q93034,P31751,Q92542,Q93050,Q15334,P05556 12
Regulation of plk1 activity at g2 m transition 0.324536488825431 0.2186937981155082 0.8268885804404837 1.0 1.0 26 P68371,P61981,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P63208,Q13409,P17612,P63167,O94927 13
Vegfr2 mediated vascular permeability 0.348286676406898 0.2116999481082256 0.8323411285860787 1.0 1.0 9 P31751,P42345 2
The role of gtse1 in g2 m progression after g2 checkpoint 0.3139734878930079 0.2056557042991054 0.8370598617046869 1.0 1.0 45 P28072,P60900,P49721 3
Assembly and cell surface presentation of nmda receptors 0.3698388327565067 0.2047891823577618 0.8377368391267692 1.0 1.0 8 Q9BUF5 1
Glucagon like peptide 1 glp1 regulates insulin secretion 0.4238464679461092 0.1959484315184425 0.8446505291113835 1.0 1.0 4 P17612,P10644,P13861 3
Extra nuclear estrogen signaling 0.3904799274177647 0.1954035527768051 0.8450770355085369 1.0 1.0 7 Q99873 1
Rho gtpases activate rocks 0.3887014373872738 0.1912762339720971 0.8483091798612341 1.0 1.0 7 P35579,O75116 2
Negative regulators of ddx58 ifih1 signaling 0.4209881584320214 0.190061708617787 0.84926077520407 1.0 1.0 4 Q96J02,Q14258,P61086 3
Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.3876094393232634 0.1887632395489358 0.8502783844179831 1.0 1.0 7 Q16763 1
Downregulation of smad2 3 smad4 transcriptional activity 0.4101725342468422 0.1844202583377359 0.8536837785223836 1.0 1.0 6 Q13573 1
Transcriptional activity of smad2 smad3 smad4 heterotrimer 0.4101725342468422 0.1844202583377359 0.8536837785223836 1.0 1.0 6 Q13573 1
Parasite infection 0.3307167405360552 0.1772965150083172 0.859275488052744 1.0 1.0 14 Q9UQB8 1
Sema4d induced cell migration and growth cone collapse 0.403537259461147 0.1708256853548497 0.8643608319318308 1.0 1.0 6 P35579,O75116 2
Muscle contraction 0.3139526888649427 0.1677935062926162 0.86674573129838 1.0 1.0 23 Q9NYL9,P30626,Q13177,P05026,P54709,O43865,P17612,P23634,P20020 9
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.308241300000436 0.1671875688763772 0.8672224653537994 1.0 1.0 45 P28072,P60900,P49721 3
Regulation of runx3 expression and activity 0.3126975630426758 0.1606198960111821 0.8723927836114256 1.0 1.0 35 P28072,P49721 2
Josephin domain dubs 0.3647490820073473 0.1588958758320209 0.8737509100247045 1.0 1.0 2 P54727 1
Aurka activation by tpx2 0.3102718056794354 0.1575983587266315 0.8747732969570587 1.0 1.0 24 P61981,Q15154,P61163,Q14203,Q7Z460,Q15691,P07437,P68371,P17612,P63167,O94927 11
Hiv transcription initiation 0.346286249075286 0.1481803378969624 0.8822004485909052 1.0 1.0 8 P29083 1
Signaling by alk in cancer 0.3112575261571239 0.1456344845969564 0.8842099434328499 1.0 1.0 28 Q13501 1
Rhod gtpase cycle 0.3105638402932528 0.145050992677528 0.8846706111429974 1.0 1.0 21 Q9Y2U8,P50402,Q14739,Q658P3 4
Met promotes cell motility 0.3895552770810777 0.1427083415810583 0.8865205285244036 1.0 1.0 5 P05556 1
Diseases of mismatch repair mmr 0.3963265306122401 0.1396936362429354 0.8889020546466575 1.0 1.0 3 P52701,P20585 2
Prevention of phagosomal lysosomal fusion 0.3942857142857078 0.1364133387148274 0.8914945294782697 1.0 1.0 3 P51149,Q9H267 2
Cross presentation of soluble exogenous antigens endosomes 0.3068420786553162 0.1326740565172362 0.894451161349904 1.0 1.0 36 P28072,P49721 2
Degradation of axin 0.3068420786553162 0.1326740565172362 0.894451161349904 1.0 1.0 36 P28072,P49721 2
Runx1 interacts with co factors whose precise effect on runx1 targets is not known 0.3174728586695727 0.1306299351578642 0.8960680608010514 1.0 1.0 11 P67870 1
Transcriptional regulation by runx3 0.3022265947617545 0.1283026872933131 0.8979094385315787 1.0 1.0 39 P28072,P60900,Q13573,P49721 4
Pkmts methylate histone lysines 0.379604962188919 0.1264589680927745 0.8993686269546528 1.0 1.0 6 Q9H7B4 1
Stabilization of p53 0.3036108249254438 0.1203892661960526 0.9041747938938314 1.0 1.0 37 P28072,P49721 2
Negative regulation of notch4 signaling 0.3016744310292215 0.1163970148896906 0.9073379010876732 1.0 1.0 38 P28072,P49721 2
Rna polymerase iii transcription initiation from type 3 promoter 0.3788444829146558 0.1158140840097972 0.907799888204041 1.0 1.0 4 O14802,O15160 2
Rna polymerase iii chain elongation 0.3788444829146558 0.1158140840097972 0.907799888204041 1.0 1.0 4 O14802,O15160 2
Cdt1 association with the cdc6 orc origin complex 0.3023951381450444 0.1134466134389044 0.9096764860368158 1.0 1.0 37 P28072,P49721 2
Interleukin 12 signaling 0.3041315076757106 0.1109847031156765 0.9116284769322428 1.0 1.0 28 P11233,Q13126,O00170,O14979 4
Metabolism of polyamines 0.3011627624154736 0.1064584021249406 0.915218658091427 1.0 1.0 37 P28072,P49721 2
Homology directed repair 0.3021565252430717 0.1020269175538224 0.9187353094473594 1.0 1.0 35 Q9UQ84,P38398,P54132,Q9UNS1 4
Formation of tubulin folding intermediates by cct tric 0.3058968058968059 0.1016676796797262 0.9190204570576176 1.0 1.0 11 P50990,P50991,P17987,P78371,Q9BUF5,Q9BVA1,P68371,P49368,P48643,Q99832 10
Pentose phosphate pathway 0.3627602815447608 0.0996858266923257 0.9205937531496556 1.0 1.0 6 O95336 1
Ras processing 0.3663366970002756 0.098320696835425 0.9216776441068028 1.0 1.0 4 P49356 1
Asymmetric localization of pcp proteins 0.2989918614197332 0.0942723104910253 0.9248928449638928 1.0 1.0 37 P28072,P49721 2
Downstream signaling events of b cell receptor bcr 0.2976381605298093 0.0931436757346356 0.9257894200119696 1.0 1.0 38 P28072,P49721 2
Regulation of hmox1 expression and activity 0.2953124103685024 0.0862368609048021 0.9312781290734872 1.0 1.0 44 P28072,P67870,P49721 3
Sumoylation of transcription factors 0.3542857142857091 0.0833295338490164 0.9335895173371478 1.0 1.0 3 Q12888,P04637 2
Regulation of runx2 expression and activity 0.2933644244064713 0.0818945065206797 0.9347306029284616 1.0 1.0 41 P28072,P49721 2
Degradation of dvl 0.2955919789248261 0.0755137808832646 0.9398059332840438 1.0 1.0 37 P28072,P49721 2
Regulation of ras by gaps 0.2955919789248261 0.0755137808832646 0.9398059332840438 1.0 1.0 37 P28072,P49721 2
Nephrin family interactions 0.3449121373109974 0.0753225686834132 0.9399580652742454 1.0 1.0 6 P12814,Q13813,P46940,Q9Y5K6,O43707 5
Interaction between l1 and ankyrins 0.3444897959183621 0.073443769850901 0.9414529883137496 1.0 1.0 3 Q13813,Q12955 2
Ncam signaling for neurite out growth 0.3444897959183612 0.0734437698509005 0.94145298831375 1.0 1.0 3 Q13813,P62993 2
Wnt5a dependent internalization of fzd2 fzd5 and ror2 0.3406862745098057 0.0718194608427406 0.9427455852993872 1.0 1.0 5 Q00610,O95782,Q96CW1,P63010 4
Wnt5a dependent internalization of fzd4 0.3406862745098057 0.0718194608427406 0.9427455852993872 1.0 1.0 5 Q00610,O95782,Q96CW1,P63010 4
Nef mediated cd8 down regulation 0.3406862745098056 0.0718194608427406 0.9427455852993872 1.0 1.0 5 O95782,Q96CW1,Q9UI12,P63010 4
Vldlr internalisation and degradation 0.3406862745098057 0.0718194608427406 0.9427455852993872 1.0 1.0 5 Q00610,O95782,Q96CW1,P63010 4
Nef mediated cd4 down regulation 0.3406862745098056 0.0718194608427406 0.9427455852993872 1.0 1.0 5 O95782,Q96CW1,Q9UI12,P63010 4
Retrograde neurotrophin signalling 0.3408255006129942 0.0703139247730215 0.9439437995731396 1.0 1.0 6 P63010,P50570,Q00610,O95782,Q96CW1 5
Collagen formation 0.2938631768032457 0.0692797215828344 0.9447669667815152 1.0 1.0 13 O60568,P13674,O15460 3
Rna polymerase iii transcription termination 0.3346806899317542 0.0652325210300963 0.9479888682247388 1.0 1.0 5 O14802,P19388,O15160 3
Signaling by notch 0.2929577236055524 0.0651785045705841 0.9480318755980646 1.0 1.0 51 P60900,P49721,Q92542,Q13573,P28072 5
Sumo is transferred from e1 to e2 ube2i ubc9 0.2774377804977499 0.0527514303751163 0.9579299605248262 1.0 1.0 2 Q9UBT2 1
Processing and activation of sumo 0.2774377804977499 0.0527514303751163 0.9579299605248262 1.0 1.0 2 Q9UBT2 1
Sumo is conjugated to e1 uba2 sae1 0.2774377804977499 0.0527514303751163 0.9579299605248262 1.0 1.0 2 Q9UBT2 1
Biosynthesis of specialized proresolving mediators spms 0.2753977968176189 0.0515608484154753 0.9588786162584692 1.0 1.0 2 P09960 1
Synthesis of leukotrienes lt and eoxins ex 0.2753977968176189 0.0515608484154753 0.9588786162584692 1.0 1.0 2 P09960 1
Aggrephagy 0.2814420319541107 0.0445443035586 0.9644705378706292 1.0 1.0 12 P61088,P08670,Q9BUF5,Q14204,Q9BVA1,P55072,P68371,Q13409,P07900,Q9Y6G9,P63167 11
Trafficking of glur2 containing ampa receptors 0.3092320261437931 0.0420639029661398 0.966447755947671 1.0 1.0 5 O95782,O94973,Q96CW1,P63010 4
Response of mtb to phagocytosis 0.2717969709373735 0.0381788753977883 0.9695450636048204 1.0 1.0 10 P00558,P49840,P51149,Q9UI12,P20339,Q9H267,Q14974,P23246,P52294 9
Infection with mycobacterium tuberculosis 0.2717969709373735 0.0381788753977883 0.9695450636048204 1.0 1.0 10 P00558,P49840,P51149,Q9UI12,P20339,Q9H267,Q14974,P23246,P52294 9
Circadian clock 0.3085410706988165 0.0378355070258407 0.9698188341175646 1.0 1.0 6 Q86X55,P63208,Q9BWF3,Q13616,P43490 5
Initiation of nuclear envelope ne reformation 0.2805215947933772 0.0355124054319476 0.9716711545112452 1.0 1.0 15 Q9Y2U8,Q14739 2
Regulation of tp53 activity 0.2895575735905982 0.0346536091370161 0.9723559532340198 1.0 1.0 33 Q9UQ84,P67870,Q92804,P31751,P54132,P38398 6
Signaling by ntrk2 trkb 0.2653061224489735 0.0292052986439975 0.976700855330904 1.0 1.0 3 P63000,P62993 2
G1 s specific transcription 0.2703476482617513 0.0254583184467974 0.9796893947628074 1.0 1.0 8 Q13547,P06493,P04818,Q9Y619,P12004,P04183,P00374 7
Degradation of gli1 by the proteasome 0.2825967798236318 0.0236945903709991 0.9810962210544658 1.0 1.0 40 P28072,P49721 2
Cytosolic iron sulfur cluster assembly 0.2844527245792713 0.0210718304994208 0.9831883559092822 1.0 1.0 6 Q6FI81 1
Chrebp activates metabolic gene expression 0.2540849673202636 0.013851084830027 0.9889487866321264 1.0 1.0 5 Q99943,P53396,P49327,O00763 4
Protein folding 0.2804902989711575 0.0070825996513248 0.9943489503337056 1.0 1.0 28 P67870,Q15477,Q9UHV9,Q9BUF5,Q99471,P04062,P68371 7
|