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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:5e48ff1763ddc6af8398ca69553d4d9417829634ad8b380695511d381eca8568
+size 81650

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3329,
+    "annotations_size": 57,
+    "title": "Average number of proteins per term",
+    "value": 2.8421052631578947
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C342/C342_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,8 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Serine carboxypeptidase, serine active site [IPR018202]	0.9738424533974744	1.661986942064216	0.0965153926992665	0.9969275614996655	0.2500626083571907	3	Q9H3G5,Q9HB40	2
+Ribonucleotide reductase small subunit, acitve site [IPR030475]	0.780583107905001	1.0561432992818989	0.2909027508669424	0.9999999969080632	0.5527152266471905	2	Q7LG56	1
+Cysteine peptidase, asparagine active site [IPR025661]	0.757439134355258	0.9641998448292228	0.334945742169364	0.9999999999200436	0.5785426455652651	2	P07858	1
+Cysteine peptidase, histidine active site [IPR025660]	0.757439134355258	0.9641998448292228	0.334945742169364	0.9999999999200436	0.5785426455652651	2	P07858	1
+Cysteine peptidase, cysteine active site [IPR000169]	0.4081525884569559	0.2120351138145455	0.8320796402253674	1.0	0.9065163332169984	5	P17655,P07858	2
+Glycosyl hydrolases family 31, active site [IPR030458]	0.4283137962127976	0.0902212948187578	0.9281113625161486	1.0	0.9446847797039368	2	P10253	1
+Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]	0.4107035478051607	0.0576987224443023	0.9539886113444018	1.0	0.9539886113444018	3	Q16881,P09622	2

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP synthase, F0 complex, subunit A, active site [IPR023011]", "ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-CoA lyase, active site [IPR000138]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Peptidase family C14A, His active site [IPR016129]", "Peptidase family C14A, cysteine active site [IPR033139]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]"], "available_proteins": ["AAK1", "ACAA1", "ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADA", "ADSS", "AKT1", "APEH", "ATP5A1", "ATP5B", "ATP6", "ATP6V1A", "ATP6V1B2", "BLMH", "BUB1", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CASP2", "CASP3", "CDC42BPB", "CDK1", "CDK11B", "CDK4", "CDK5", "CDK6", "CHEK1", "CHEK2", "CHUK", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSB", "CTSC", "DLD", "DNMT1", "DUSP3", "EGFR", "EIF2AK2", "EIF2AK4", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSK3A", "GSK3B", "GSR", "GUSB", "HADHB", "HMGCL", "HMGCS1", "IGF1R", "IKBKB", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K3", "MAPK1", "MAPK3", "MARK1", "MARK2", "MDH1", "MDH2", "MTMR2", "NEK9", "NME1", "NME2", "NME3", "OXCT1", "PAK1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKN1", "PKN2", "PLK1", "PREP", "PRKAA1", "PRKAA2", "PRKACA", "PRKCD", "PRPF4B", "PTK7", "PTPN1", "PTPN11", "PTPN23", "PTPN9", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "RRM2", "RRM2B", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SRPK2", "SUCLG1", "TALDO1", "TIGAR", "TOP1", "TPI1", "TPP2", "TRIO", "TTK", "TXNRD1", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2G2", "UBE2K", "UBE2L3", "UBE2M", "UBE2N", "UBE2S", "UBE2T", "UMPS", "VRK1", "VRK2", "WNK1", "WNK2"], "leading_proteins": ["CAPN2", "CPVL", "CTSB", "DLD", "GAA", "RRM2B", "SCPEP1", "TXNRD1"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:2b75b99602228e571ad59aec32ff0c26f188f518a31c30b411205fb6faf3747c
+size 76120

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3329,
+    "annotations_size": 31,
+    "title": "Average number of proteins per term",
+    "value": 4.903225806451613
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C342/C342_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,5 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+EF-Hand 1, calcium-binding site [IPR018247]	0.4667962976562564	1.638589054372743	0.1012988734366666	0.9635184006861652	0.3284429590733821	40	Q9Y680,Q02818,P80303,Q96AY3,Q14257	5
+Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]	0.91794409377818	1.6166708858695076	0.1059493416365748	0.96893824806271	0.3284429590733821	2	P34896	1
+Hexokinase, binding site [IPR019807]	0.7171626089570039	0.8082651094792781	0.4189379833195228	0.9999999509208424	0.6684387730313582	2	P52789	1
+Peptidase M16, zinc-binding site [IPR001431]	0.3038507821901392	0.0208099389752326	0.9833972693009996	1.0	1.0	5	Q10713,P14735,P22695,O75439	4

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "RNA polymerases, subunit N, zinc binding site [IPR020789]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT1", "APEX1", "APOBEC3C", "BPNT1", "BUB1", "CALM3", "CALU", "CAMK1", "CAMK2G", "CAPN1", "CAPN2", "CAPNS1", "CDC42BPB", "CDK1", "CDK4", "CDK5", "CDK6", "CETN2", "CHEK1", "CHUK", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DCTD", "DLAT", "DLST", "DST", "EGFR", "EHD1", "EHD4", "EIF2AK2", "EIF2AK4", "EPS15", "EPS15L1", "FKBP10", "FKBP14", "FKBP7", "GCAT", "GOT1", "GOT2", "GPD2", "GSK3A", "GSK3B", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IMPA1", "IQGAP1", "IQGAP2", "ITSN2", "LETM1", "MACF1", "MAP2K1", "MAP2K3", "MAPK1", "MAPK14", "MAPK3", "MARK1", "MARK2", "MCCC1", "METAP2", "MICU1", "MYH10", "MYH14", "MYH9", "MYO18A", "MYO1B", "MYO1C", "MYO1D", "NFS1", "NRDC", "NUCB1", "NUCB2", "OXCT1", "OXSR1", "PA2G4", "PAK1", "PAK2", "PAK4", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKN1", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "POLR2L", "PPM1G", "PRKAA1", "PRKAA2", "PRKACA", "PRKCD", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "ROCK2", "RPS6KA1", "RPS6KA3", "S100A11", "SDF4", "SDHA", "SDHB", "SHMT1", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "SRPK2", "STK26", "STK4", "TBK1", "TKT", "TTK", "TUBB", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["FKBP10", "FKBP7", "HK2", "IDE", "NUCB1", "NUCB2", "PMPCA", "PMPCB", "RCN2", "SHMT1", "UQCRC2"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "14-3-3 protein, conserved site [IPR023409]"}

interpro_conserved_site/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:d4e3b0f375735683e16d2bb461897d016d22b64c41ac959a34107352175de54b
+size 95599

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,2 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Proteasome beta-type subunit, conserved site [IPR016050]	4	8	2.559950887729327	0.0104686956440109	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	0.002691599026727	1.0	0.0039921150854813	1.8654270901726772e-06	5.5966724052351854e-05

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3329,
+    "annotations_size": 275,
+    "title": "Average number of proteins per term",
+    "value": 2.7854545454545456
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C342/C342_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,33 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteasome beta-type subunit, conserved site [IPR016050]	0.8816010698664067	2.559950887729327	0.0104686956440109	0.9446493248781594	0.1199538042542925	8	P49721,P28070,P28074,P28072	4
+Haem oxygenase conserved site [IPR018207]	0.9843703035767944	1.8880400209766384	0.0590205778978827	0.9999999457331412	0.2687565211881426	2	P30519	1
+Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]	0.8026898677752794	1.7198268020639045	0.0854639291467145	0.999999999978609	0.331022260779528	5	P48735	1
+Sterol reductase, conserved site [IPR018083]	0.9296663660955744	1.664737341611549	0.0959651695802898	0.9999999999991068	0.3566273193862124	2	Q14739	1
+Syntaxin/epimorphin, conserved site [IPR006012]	0.7145006016847399	1.359654208135973	0.1739393753166065	1.0	0.4836443998871719	5	Q86Y82,O43752,Q9P2W9,O15400	4
+C-type lectin, conserved site [IPR018378]	0.8452058911932679	1.3181853372386925	0.1874416127352818	1.0	0.4956388798288701	2	Q9UBG0	1
+Intermediate filament protein, conserved site [IPR018039]	0.5836940043204155	1.2160689699134208	0.223958649869659	1.0	0.5227691725917821	8	P08670,P07196	2
+Methylthiotransferase, conserved site [IPR020612]	0.8151487826870957	1.1955907587819083	0.2318562994889956	1.0	0.5323999203569962	2	Q5VV42	1
+Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]	0.8103396453261168	1.1760713510050298	0.2395663650537396	1.0	0.5385020741473621	2	P04439	1
+Tetraspanin, conserved site [IPR018503]	0.839278149833835	1.1621857678919758	0.2451600144400165	1.0	0.5393520317680365	3	O43657	1
+Guanylate kinase, conserved site [IPR020590]	0.6354123378081854	1.033455954719826	0.3013905725268491	1.0	0.5900549796881295	5	Q14168	1
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.7598437030357483	0.9736853915185676	0.3302127728982911	1.0	0.6053900836468671	2	Q9BTY2	1
+Dynamin, GTPase region, conserved site [IPR019762]	0.7081454764051706	0.7742663452670719	0.4387733014047337	1.0	0.6802467830117492	2	O00429	1
+Homeobox, conserved site [IPR017970]	0.6762849413886243	0.6575793676567618	0.51080845594598	1.0	0.7496259326038072	2	P35453	1
+Clathrin adaptor complex, small chain [IPR000804]	0.6696723775172831	0.6341309949488735	0.5259953365179979	1.0	0.7573231284944996	2	P61923	1
+Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]	0.4904307861052397	0.5418993256364207	0.5878878613598084	1.0	0.7965264303583869	6	P42356	1
+Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]	0.6083558761647112	0.4329541800099243	0.665048057744136	1.0	0.83131007218017	2	Q07812	1
+Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]	0.6083558761647112	0.4329541800099243	0.665048057744136	1.0	0.83131007218017	2	Q07812	1
+Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]	0.6083558761647112	0.4329541800099243	0.665048057744136	1.0	0.83131007218017	2	Q07812	1
+RNA polymerase, beta subunit, conserved site [IPR007121]	0.60414788097384	0.4204063293832003	0.6741886451188714	1.0	0.8389225222067406	2	P30876	1
+ABC transporter-like, conserved site [IPR017871]	0.4012703803566901	0.4115558702285614	0.680664982620439	1.0	0.8396579239260222	9	Q03518	1
+14-3-3 protein, conserved site [IPR023409]	0.4363526933493882	0.3443635797575755	0.7305728749219027	1.0	0.8585792333483899	6	P61981,P27348,P63104,P62258,Q04917	5
+Dynein light chain, type 1/2, conserved site [IPR019763]	0.5716862037872026	0.3300877929867153	0.7413336265801576	1.0	0.863842149616709	2	Q96FJ2	1
+Heat shock protein Hsp90, conserved site [IPR019805]	0.5505111244738319	0.2473463292112794	0.8046402068741205	1.0	0.903167579144421	3	P14625,P07900	2
+Chromo domain, conserved site [IPR023779]	0.4763909774436118	0.2342593344446463	0.8147836540059661	1.0	0.9068695481817992	4	Q13185,P83916,P45973	3
+HMG box A DNA-binding domain, conserved site [IPR017967]	0.5336740829825575	0.2129917806653934	0.8313333736761817	1.0	0.9144667110437998	3	P26583,O15347	2
+IMP dehydrogenase / GMP reductase, conserved site [IPR015875]	0.508265704839207	0.1910077773588506	0.8485194998911771	1.0	0.92596373996061	2	P12268	1
+DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]	0.4959422903516644	0.1701561649840887	0.8648873241983186	1.0	0.9324734836793014	2	O15160	1
+Thioredoxin, conserved site [IPR017937]	0.3229886211710366	0.1444116574294752	0.8851754120026056	1.0	0.9362432242335252	13	O43396,Q9H1E5,O95881	3
+Glycosyl hydrolases family 31, conserved site [IPR030459]	0.4283137962127976	0.0902212948187578	0.9281113625161486	1.0	0.9653588858024892	2	P10253	1
+Histidine triad, conserved site [IPR019808]	0.4186955214908319	0.083108430754849	0.9337653222671348	1.0	0.9653588858024892	2	Q96C86	1
+Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]	0.361329264957037	0.0351463194130999	0.9719630666580276	1.0	0.9864272122915236	3	P28482	1

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Aminotransferase, class IV, conserved site [IPR018300]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Band 7/stomatin-like, conserved site [IPR018080]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Clusterin, conserved site [IPR033986]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA mismatch repair, conserved site [IPR014762]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "Dihydroorotate dehydrogenase, conserved site [IPR001295]", "DnaJ domain, conserved site [IPR018253]", "Dpy-30 motif [IPR007858]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "Ependymin, conserved site [IPR018224]", "Eukaryotic translation initiation factor 4E (eIF-4E), conserved site [IPR019770]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "FHF complex subunit HOOK interacting protein, KELAA motif [IPR045668]", "FLAP/GST2/LTC4S, conserved site [IPR018295]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "GoLoco motif [IPR003109]", "Golgin subfamily A member 2, C-terminal binding motif [IPR043937]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Helix-turn-helix motif [IPR000047]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Homeobox, conserved site [IPR017970]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysophospholipase patatin, conserved site [IPR001423]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Mrp, conserved site [IPR000808]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site [IPR001949]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site [IPR023058]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosyl pyrophosphate synthetase, conserved site [IPR000842]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Pseudouridine synthase, RluC/RluD, conserved site [IPR006224]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Pyridoxamine 5'-phosphate oxidase, conserved site [IPR019740]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Rel homology domain, conserved site [IPR030492]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S21e, conserved site [IPR018279]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Transcription factor TFIIB, conserved site [IPR023486]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AACS", "AAMP", "ABCB1", "ABCB7", "ABCC4", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA1", "ACAA2", "ACAD9", "ACADM", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACSL6", "ACTL6A", "ACTN1", "ACTN2", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AK4", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1A2", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "APEX1", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAX", "BAZ1A", "BAZ1B", "BCAT2", "BCS1L", "BDH2", "BLM", "BOP1", "BPNT1", "BPTF", "BRCA1", "BRD2", "BRD4", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAP2", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBL", "CBR1", "CBX1", "CBX3", "CBX5", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDK5RAP1", "CDKAL1", "CDX2", "CECR2", "CENPE", "CETN2", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CLGN", "CLU", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1B", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF7", "DCP2", "DCPS", "DCXR", "DDT", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHODH", "DHRS4", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DIS3L2", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC21", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DPY30", "DRG1", "DRG2", "DSC3", "DSG2", "DST", "DTL", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "ECT2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "EIF4E", "EIF4E2", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L5", "EPDR1", "EPN1", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FAM160A2", "FBL", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLO1", "GMPPA", "GMPPB", "GNPDA1", "GNS", "GOLGA2", "GPHN", "GPI", "GPSM1", "GRHPR", "GRWD1", "GSPT1", "GTF2B", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGB1", "HMGB2", "HMGB3", "HMOX1", "HMOX2", "HOXD13", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA6", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IDH3G", "IGF1R", "ILVBL", "IMPA1", "IMPAD1", "IMPDH1", "IMPDH2", "INA", "INTS12", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDSR", "KIF11", "KIF14", "KIF1B", "KIF20A", "KIF20B", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF3A", "KIF4A", "KIF5B", "KIF5C", "KIFC1", "LAMP1", "LAMP2", "LARS", "LARS2", "LBR", "LDLR", "LIG1", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MAPK3", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MGST2", "MID1", "MIF", "MKRN2", "MPI", "MPP1", "MPP2", "MPP6", "MPP7", "MPST", "MRC2", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "MVK", "NDUFS1", "NDUFS2", "NDUFS3", "NDUFS8", "NDUFV1", "NEFL", "NEFM", "NES", "NFKB1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD1", "NSD2", "NSF", "NSUN6", "NUBPL", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL3", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA5", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF2", "PHF3", "PHF8", "PHGDH", "PHIP", "PI4KA", "PI4KB", "PIK3C2A", "PIK3C3", "PIN1", "PLEC", "PLOD1", "PLOD2", "PLOD3", "PLRG1", "PLS1", "PLS3", "PMS1", "PNP", "PNPLA6", "PNPO", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "PPIB", "PPIC", "PPID", "PPIE", "PPIF", "PPIH", "PPIL1", "PPIL3", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKAR2B", "PRKDC", "PRPF19", "PRPF4", "PRPS1", "PRPS2", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PSMD4", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "QDPR", "RACK1", "RAE1", "RANBP2", "RARS", "RARS2", "RBBP7", "RCL1", "RDH13", "RDX", "RECQL5", "RIDA", "RNF14", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS21", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RPUSD2", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTCA", "S100A10", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLIT2", "SMARCA4", "SMS", "SMU1", "SNRNP40", "SNU13", "SORD", "SPATA5", "SPATA5L1", "SPTBN1", "SPTBN2", "SRCAP", "SRM", "STAM", "STMN1", "STOM", "STRN", "STX12", "STX18", "STX4", "STX6", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SYNE1", "SYNE2", "TAP1", "TBL1XR1", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMX1", "TMX3", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM27", "TRIM28", "TRIM33", "TRIM4", "TRIP13", "TRMT11", "TSFM", "TSPAN10", "TSPAN3", "TSPAN6", "TTF2", "TUBB", "TUBB2B", "TUBB3", "TUBB4A", "TUBB4B", "TUBB6", "TUFM", "TXN2", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBA5", "UHRF1", "USP10", "USP11", "USP14", "USP15", "USP24", "USP28", "USP47", "USP48", "USP5", "USP7", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VARS2", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WARS2", "WDHD1", "WDR1", "WDR12", "WDR18", "WDR3", "WDR36", "WDR41", "WDR48", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["BAX", "CBX1", "CBX3", "CBX5", "CDKAL1", "COPZ1", "DCPS", "DNM1L", "DYNLL2", "FUCA2", "GAA", "HLA-A", "HMGB2", "HMGB3", "HMOX2", "HOXD13", "HSP90AA1", "HSP90B1", "IDH2", "IMPDH2", "LBR", "MAPK1", "MPP2", "MRC2", "NEFL", "PI4KA", "POLR1C", "POLR2B", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "STX12", "STX18", "STX6", "STX7", "TAP1", "TMX4", "TSPAN6", "TXNDC12", "TXNL1", "VIM", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]", "1": "EF-hand domain [IPR002048]", "2": "K Homology domain, type 1 [IPR004088]", "3": "K Homology domain [IPR004087]", "4": "RNA recognition motif domain, eukaryote [IPR003954]", "5": "Immunoglobulin-like domain [IPR007110]", "6": "Rab-GTPase-TBC domain [IPR000195]", "7": "RNA recognition motif domain [IPR000504]", "8": "SH3 domain [IPR001452]", "9": "Band 7 domain [IPR001107]", "10": "14-3-3 domain [IPR023410]", "11": "Zinc finger, LIM-type [IPR001781]", "12": "CS domain [IPR007052]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:a77f7a06002041516d75c4ad7bfac3f859f59f7a48d140ab50a4f0fb7a52a633
+size 371884

interpro_domain/df_merge.tsv

@@ -0,0 +1,4 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	6	10	2.7295817213392204	0.0063414729438826	3.1262135922330097	10.111650485436892	0.9686720267359892	0.3700536707457866	1.7316562118191232	1.203619216216406	0.9607394322697528	0.3108814801432357	0.0001304500459516	3.066034551708988e-05	5.5913743904608274e-06	7.014604493490859e-09	8.443744114806333e-07
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	3	5	2.1224466154658232	0.0338002511723951	2.813106796116505	6.104368932038835	1.6405397264547834	0.1100883340733615	1.2852875686886795	0.8042848477475721	1.100790504333474	0.1612592696854457	0.0039071928268104	0.0573151884822011	0.0057815105752346	0.0001450038876457	0.0020333503076747
+Alcohol dehydrogenase, N-terminal [IPR013154]	0	5	1.9744548728715008	0.0483300438814899	1.3762135922330097	5.245145631067961	0.6000738304798152	0.3870290227769069	1.1994000251783288	0.9246362329357484	1.1062357688130569	0.3020782188917261	0.0692945510525022	0.0432957136582515	0.0841007109914387	0.1988473022417859	0.3629223192764827

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 3329,
+    "annotations_size": 2693,
+    "title": "Average number of proteins per term",
+    "value": 2.1927218715187524
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C342/C342_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,213 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+FKBP-type peptidyl-prolyl cis-trans isomerase domain [IPR001179]	0.8834765937961775	2.7295817213392204	0.0063414729438826	0.9999999637187652	0.0954807901344428	10	P62942,P26885,Q9Y680,Q02790,Q96AY3,Q9NWM8	6
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.9042777294053956	2.1224466154658232	0.0338002511723951	1.0	0.1482476814450491	5	O43169,O15173,Q9UMX5	3
+EF-hand domain [IPR002048]	0.4740321508317648	1.9061484977138503	0.0566309420274548	1.0	0.1983103699450978	49	Q9Y680,Q02818,Q66K14,Q0IIM8,Q96D71,O43852,P80303,Q96AY3,Q14257,Q9NWM8,O75340,O75071,P0DP25	13
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8469948171244304	1.897298412488972	0.0577885644030908	1.0	0.1996060411491266	5	P55786,Q9UIQ6,Q9NZ08	3
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8469948171244304	1.897298412488972	0.0577885644030908	1.0	0.1996060411491266	5	P55786,Q9UIQ6,Q9NZ08	3
+EXPERA domain [IPR033118]	0.9705440336639588	1.8317965011957436	0.0669817447227094	1.0	0.2181158869870091	2	Q5BJF2	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.7998876207933959	1.8262175224260544	0.0678175029643983	1.0	0.2195102589941403	6	P49327,Q8N4Q0	2
+Reticulon [IPR003388]	0.9193572784989376	1.8044970511955984	0.0711534210212603	1.0	0.2259624561441675	4	Q16799	1
+Glutathione S-transferase, N-terminal [IPR004045]	0.6797184304204351	1.7709880864012095	0.0765626828767522	1.0	0.2362430324035664	9	O15217	1
+Glutathione S-transferase, C-terminal [IPR004046]	0.6661540318415667	1.7674201917577808	0.0771578838385156	1.0	0.2374699213452829	11	O15217	1
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.9507063420498916	1.7508510435910751	0.0799715715275013	1.0	0.2408987048361981	2	Q15629	1
+Zinc finger, RanBP2-type [IPR001876]	0.6735948006834193	1.7417763447567731	0.0815475874809328	1.0	0.2421253065999471	9	Q01844,Q92804,P35637	3
+Isopropylmalate dehydrogenase-like domain [IPR024084]	0.8026898677752794	1.7198268020639045	0.0854639291467145	1.0	0.2509862172214855	5	P48735	1
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.9392846408175504	1.7041325275201098	0.0883563309887311	1.0	0.2552561655016699	2	P98179	1
+K Homology domain, type 1 [IPR004088]	0.5100141742180068	1.671598365259578	0.0946035473559667	1.0	0.2656593879349515	26	P51116,P61978,O75525,Q92945,Q96AE4,Q96I24,Q06787,P51114,Q9Y2W6	9
+YTH domain [IPR007275]	0.7895276701523062	1.6665954577874065	0.0955948726974802	1.0	0.2673281330989764	5	Q7Z739,Q9H6S0,Q9Y5A9	3
+Prolyl 4-hydroxylase alpha-subunit, N-terminal [IPR013547]	0.9242560865644736	1.6425593235928824	0.1004741425719304	1.0	0.2758173964793156	2	P13674	1
+Glutathione S-transferase, C-terminal-like [IPR010987]	0.602627524913507	1.6366967631730531	0.1016938456430232	1.0	0.2772082252493513	13	O15217	1
+Serine hydroxymethyltransferase-like domain [IPR039429]	0.91794409377818	1.6166708858695076	0.1059493416365748	1.0	0.2858933637548057	2	P34896	1
+Peptidase S9A, N-terminal domain [IPR023302]	0.908926961226326	1.579665935706802	0.1141833905981832	1.0	0.3000758132937635	2	P48147	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.9071235347159602	1.5722625067481373	0.1158896844632548	1.0	0.3026735887845719	2	O60506	1
+Fragile X-related 1 protein, C-terminal region 1 [IPR032172]	0.9047189660354692	1.5623902501382103	0.1181960825419401	1.0	0.3068655543235056	2	P51116	1
+GRAM domain [IPR004182]	0.8524408086204942	1.5486676438358018	0.1214616358073941	1.0	0.3123562586329474	4	Q0IIM8,Q969T9	2
+P-type ATPase, haloacid dehalogenase domain [IPR044492]	0.7539943771241531	1.5218790146467065	0.1280393982865071	1.0	0.3231050199685626	5	Q9NQ11,Q9HD20	2
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.6435135669571694	1.500317435768149	0.1335321950774033	1.0	0.3295663661994017	8	P13674,Q32P28	2
+GMP phosphodiesterase, delta subunit [IPR008015]	0.8893898406973129	1.4994376476561837	0.1337601330322859	1.0	0.3295663661994017	2	A6NIH7	1
+ERAP1-like C-terminal domain [IPR024571]	0.927841250751648	1.4911912070740985	0.1359113015556599	1.0	0.3312299865062372	3	Q9UIQ6,Q9NZ08	2
+Far upstream element-binding protein, C-terminal [IPR015096]	0.8818755635707864	1.4685767718898457	0.1419476189389166	1.0	0.3389385620109603	2	Q96AE4	1
+CARG-binding factor, N-terminal [IPR012956]	0.8785692816351078	1.4549996687837243	0.1456693531933812	1.0	0.345019848856443	2	Q99729	1
+Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]	0.8271899567605905	1.4513077947052793	0.1466941717757355	1.0	0.3468370540755537	4	Q4J6C6,P48147	2
+CTP synthase, N-terminal [IPR017456]	0.8761647129546055	1.445126478636242	0.1484223627154777	1.0	0.3489773589957096	2	P17812	1
+CTP synthase GATase domain [IPR033828]	0.8761647129546055	1.445126478636242	0.1484223627154777	1.0	0.3489773589957096	2	P17812	1
+K Homology domain [IPR004087]	0.4761663750087711	1.3995767854872558	0.161640089688871	1.0	0.3714136190547181	25	P51116,P61978,O75525,Q92945,Q96AE4,Q96I24,Q06787,P51114,Q9Y2W6	9
+RNA recognition motif domain, eukaryote [IPR003954]	0.5402163989836916	1.3941502990198031	0.1632722227760483	1.0	0.3735701749667784	14	Q8TBF4,Q01081,Q14011,P11940,P38159,Q9UHX1,Q01085	7
+Zinc finger, CHHC-type [IPR012996]	0.8995790739627147	1.3860025648887626	0.1657461202970185	1.0	0.3760562407671241	3	P31943,P55795	2
+SH2 domain [IPR000980]	0.5953647413259646	1.3613336659705948	0.1734082684938505	1.0	0.3859408818627598	9	P46108,Q7KZ85	2
+PA domain [IPR003137]	0.8539224526600399	1.3538801892838987	0.1757746048240172	1.0	0.3886766095250415	2	Q8TCT8	1
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.6490163267404275	1.3532721229008873	0.1759687116221822	1.0	0.3886766095250415	7	P13674,Q32P28	2
+GYF domain [IPR003169]	0.8512173128944887	1.3427974854355331	0.1793375578573086	1.0	0.3945571057623834	2	O95400	1
+CD209-like, C-type lectin-like domain [IPR033989]	0.8452058911932679	1.3181853372386925	0.1874416127352818	1.0	0.4010423768317462	2	Q9UBG0	1
+C-type lectin-like [IPR001304]	0.8452058911932679	1.3181853372386925	0.1874416127352818	1.0	0.4010423768317462	2	Q9UBG0	1
+Target SNARE coiled-coil homology domain [IPR000727]	0.6045935474243659	1.3159135851364856	0.1882030485095212	1.0	0.4013684110493573	8	Q86Y82,O43752,O95721	3
+Exportin-2, central domain [IPR013713]	0.8780749404469471	1.306003144690019	0.1915514881651385	1.0	0.406179651676156	3	O95373	1
+Fxr1, tudor domain [IPR041560]	0.8767288033674043	1.3009993750924018	0.1932586686276542	1.0	0.4077172939388809	3	P51116,P51114	2
+Synaptic functional regulator FMRP, KH0 domain [IPR040472]	0.8767288033674043	1.3009993750924018	0.1932586686276542	1.0	0.4077172939388809	3	P51116,P51114	2
+Agenet-like domain [IPR008395]	0.8767288033674043	1.3009993750924018	0.1932586686276542	1.0	0.4077172939388809	3	P51116,P51114	2
+Fragile X-related 1 protein, C-terminal core [IPR022034]	0.8767288033674043	1.3009993750924018	0.1932586686276542	1.0	0.4077172939388809	3	P51116,P51114	2
+Intermediate filament head, DNA-binding domain [IPR006821]	0.785687800638013	1.2908482396415473	0.1967563065926114	1.0	0.4115456903335475	4	P08670,P07196	2
+Dynamin-type guanine nucleotide-binding (G) domain [IPR030381]	0.6326893090690588	1.2801097643531585	0.2005065350618209	1.0	0.4163177323989851	7	O60313	1
+Dynamin, N-terminal [IPR045063]	0.6326893090690588	1.2801097643531585	0.2005065350618209	1.0	0.4163177323989851	7	O60313	1
+GOLD domain [IPR009038]	0.6655566914527764	1.2670771174555462	0.2051277166730005	1.0	0.4216967438322965	6	Q15363	1
+Mad3/Bub1 homology region 1 [IPR013212]	0.8325819056206792	1.2665874329268605	0.2053028483290615	1.0	0.4216967438322965	2	O60566	1
+Small G protein signalling modulator 1/2, Rab-binding domain [IPR021935]	0.8313796212804307	1.2616805931878698	0.2070637428715884	1.0	0.4233515577282893	2	Q8TC07	1
+Peptidase M28 [IPR007484]	0.8541791942272973	1.2173061479460263	0.2234877560395243	1.0	0.4418887863542136	3	Q969V3,Q7Z2K6	2
+Intermediate filament, rod domain [IPR039008]	0.5836940043204155	1.2160689699134208	0.223958649869659	1.0	0.4419119278021088	8	P08670,P07196	2
+L27 domain [IPR004172]	0.762646733812635	1.201799560673226	0.2294411957283308	1.0	0.4477428551423152	4	Q14168	1
+L27 domain, C-terminal [IPR014775]	0.762646733812635	1.201799560673226	0.2294411957283308	1.0	0.4477428551423152	4	Q14168	1
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.762437135595667	1.2009903919304992	0.2297549283789481	1.0	0.4480304287650307	4	P13674,Q32P28	2
+Methylthiotransferase, N-terminal [IPR013848]	0.8151487826870957	1.1955907587819083	0.2318562994889956	1.0	0.4485553265257653	2	Q5VV42	1
+TRAM domain [IPR002792]	0.8151487826870957	1.1955907587819083	0.2318562994889956	1.0	0.4485553265257653	2	Q5VV42	1
+Radical SAM [IPR007197]	0.8151487826870957	1.1955907587819083	0.2318562994889956	1.0	0.4485553265257653	2	Q5VV42	1
+Elp3/MiaB/NifB [IPR006638]	0.8151487826870957	1.1955907587819083	0.2318562994889956	1.0	0.4485553265257653	2	Q5VV42	1
+Immunoglobulin-like domain [IPR007110]	0.5142066004325474	1.1512489224076006	0.2496298437940103	1.0	0.4699165819573803	13	P10321,P10586,P04439,Q9Y639,P35613	5
+Importin-beta, N-terminal domain [IPR001494]	0.5132910006513034	1.1461441474368752	0.2517355133598009	1.0	0.471763213276231	13	O95373,O15397,Q9HAV4,Q92973	4
+Armadillo repeat-containing domain [IPR006911]	0.8019236549443973	1.1419941130155786	0.2534564667091503	1.0	0.4736698576320207	2	Q8N2F6	1
+Pericentrin/AKAP-450 centrosomal targeting domain [IPR019528]	0.8016230838593355	1.1407791371563825	0.2539618445951817	1.0	0.4741019322658008	2	O95613	1
+Glutamine amidotransferase type 2 domain [IPR017932]	0.8245405702071451	1.1078773902197074	0.2679147713692882	1.0	0.4858548682138001	3	Q06210	1
+PABP, RNA recognition motif 2 [IPR045305]	0.7902013826269894	1.0947272592094206	0.2736361425707079	1.0	0.4932410521706267	2	P11940	1
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.8205051112447317	1.0930502789867114	0.2743717247889545	1.0	0.4942361570947522	3	O43823,Q5BKZ1	2
+SUN coiled coil domain 2 [IPR040994]	0.7892996693718056	1.0911019332611975	0.2752280322650224	1.0	0.4944556977249537	2	O94901	1
+Legume-like lectin [IPR005052]	0.7865945296062349	1.080235708831364	0.2800372307453513	1.0	0.4979125069245987	2	P49257	1
+Tim44-like domain [IPR007379]	0.7847911030958854	1.072999892982385	0.2832711641469914	1.0	0.5012150098868908	2	Q9BRJ2	1
+Sam68, tyrosine-rich domain [IPR032335]	0.7835888187556177	1.0681798173558392	0.2854394069860606	1.0	0.5021434496525525	2	O75525	1
+KHDRBS, Qua1 domain [IPR032571]	0.7835888187556177	1.0681798173558392	0.2854394069860606	1.0	0.5021434496525525	2	O75525	1
+GPAT/DHAPAT, acyltransferase domain [IPR041728]	0.7826871055004534	1.064566791975326	0.2870720140885119	1.0	0.5021434496525525	2	O15228	1
+Glycerol-3-phosphate acyltransferase-like, C-terminal domain [IPR045520]	0.7826871055004534	1.064566791975326	0.2870720140885119	1.0	0.5021434496525525	2	O15228	1
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.8126879134094951	1.0643896641822015	0.2871522140605016	1.0	0.5021434496525525	3	Q9BYT8,Q99797	2
+Rab-GTPase-TBC domain [IPR000195]	0.5312892946053379	1.0636311642709708	0.2874958188920247	1.0	0.502418066370034	10	O60343,Q66K14,Q8TC07,Q0IIM8,Q9BXI6	5
+Phox homology [IPR001683]	0.4973308306280906	1.057033631237736	0.2904962388721606	1.0	0.5043369980185521	13	Q96L92,Q9UMY4,Q9Y2I1	3
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.8105832832230833	1.056688171025116	0.2906539253341229	1.0	0.5043369980185521	3	P04439,P10321	2
+MHC class I, alpha chain, C-terminal [IPR010579]	0.8105832832230833	1.056688171025116	0.2906539253341229	1.0	0.5043369980185521	3	P04439,P10321	2
+MHC class I-like antigen recognition-like [IPR011161]	0.8105832832230833	1.056688171025116	0.2906539253341229	1.0	0.5043369980185521	3	P04439,P10321	2
+Immunoglobulin C1-set [IPR003597]	0.8105832832230833	1.056688171025116	0.2906539253341229	1.0	0.5043369980185521	3	P04439,P10321	2
+RNA recognition motif domain [IPR000504]	0.3874866991521339	1.0507594762853112	0.2933690719066462	1.0	0.5069721279697246	120	Q86V81,Q13242,P11940,P55795,Q14103,Q8IZ69,O60506,Q9BWF3,P98175,Q15056,Q8NDT2,O43347,Q8IY67,O43390,P31942,Q9UHX1,Q99729,Q13247,Q13310,Q96PK6,Q01085,P31943,A0AV96,Q07955,P22626,Q14011,P62995,O14979,P52597,P09651,Q13148,P26368,Q93062,Q8TBF4,Q01081,P51991,Q92804,Q01844,P38159,P98179,P23588,P35637	42
+CYRIA/CYRIB, Rac1 binding domain [IPR009828]	0.8024654239326374	1.027046612672476	0.3043985157169673	1.0	0.5165376199280359	3	Q7L576,Q9NUQ9	2
+Fibronectin type II domain [IPR000562]	0.7958508719182146	1.0029756496320632	0.3158726101925211	1.0	0.5271471059981332	3	Q9UBG0,P11717	2
+SPRY domain [IPR003877]	0.4859774049837958	0.9935559714011444	0.3204390882874879	1.0	0.5284399661715891	13	P19474	1
+B30.2/SPRY domain [IPR001870]	0.4859774049837958	0.9935559714011444	0.3204390882874879	1.0	0.5284399661715891	13	P19474	1
+Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]	0.7904389657245894	0.9833405976480414	0.3254398355718244	1.0	0.5289248429026316	3	O95071,P11940	2
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.7598437030357483	0.9736853915185676	0.3302127728982911	1.0	0.5312704832319135	2	Q9BTY2	1
+Peptidase C1A, papain C-terminal [IPR000668]	0.757439134355258	0.9641998448292228	0.334945742169364	1.0	0.5349962919020638	2	P07858	1
+Homeobox domain [IPR001356]	0.700477686802075	0.9635190530015708	0.3352871073108385	1.0	0.5349962919020638	4	Q96G23	1
+MD-2-related lipid-recognition domain [IPR003172]	0.757138563270203	0.963015348887208	0.3355398206545064	1.0	0.5349962919020638	2	P17900	1
+DNA2/NAM7 helicase-like, C-terminal [IPR041679]	0.6999096171283062	0.9613659827595432	0.3363681820509372	1.0	0.5359997125817597	4	P51530	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.7781923142520087	0.9391265838323924	0.3476657569323294	1.0	0.5484849932154441	3	Q9BUJ2	1
+OCRE domain [IPR041591]	0.7397054403366192	0.894806317313646	0.3708906327383388	1.0	0.5675048147524695	2	P98175	1
+Phospholipid/glycerol acyltransferase [IPR002123]	0.6816242111963634	0.892415481194858	0.3721702762402419	1.0	0.5684346634189137	4	O15228,Q9HCL2	2
+EB1, C-terminal [IPR004953]	0.7388037270814363	0.8913064237680492	0.372764803415448	1.0	0.5684346634189137	2	Q15555	1
+PTB/PI domain [IPR006020]	0.6770311221536602	0.8752160143540325	0.3814563812436127	1.0	0.5775102434669152	4	O60343	1
+Cold shock domain [IPR011129]	0.5891307461829052	0.844965893609257	0.398129881962461	1.0	0.5920285875896784	5	P16989	1
+Cold-shock protein, DNA-binding [IPR002059]	0.5891307461829052	0.844965893609257	0.398129881962461	1.0	0.5920285875896784	5	P16989	1
+Hexokinase, N-terminal [IPR022672]	0.7171626089570039	0.8082651094792781	0.4189379833195228	1.0	0.6065591339136962	2	P52789	1
+Hexokinase, C-terminal [IPR022673]	0.7171626089570039	0.8082651094792781	0.4189379833195228	1.0	0.6065591339136962	2	P52789	1
+LEM domain [IPR003887]	0.5497517726172032	0.7796704469000352	0.4355848783710894	1.0	0.6193277710537687	6	Q86XL3	1
+Major facilitator superfamily domain [IPR020846]	0.651155424736652	0.7794294563991248	0.4357267775929241	1.0	0.6193277710537687	4	Q6NT16	1
+GTPase effector domain [IPR020850]	0.7081454764051706	0.7742663452670719	0.4387733014047337	1.0	0.6193277710537687	2	O00429	1
+Dynamin GTPase effector [IPR003130]	0.7081454764051706	0.7742663452670719	0.4387733014047337	1.0	0.6193277710537687	2	O00429	1
+Dynamin stalk domain [IPR000375]	0.7081454764051706	0.7742663452670719	0.4387733014047337	1.0	0.6193277710537687	2	O00429	1
+ATPase family AAA domain-containing protein 3, N-terminal [IPR021911]	0.7003306281935697	0.7451237197495527	0.4561969310210139	1.0	0.6348869650420814	2	Q5T9A4	1
+Nucleotidyl transferase domain [IPR005835]	0.7221888153938527	0.7420742844567905	0.4580423293667484	1.0	0.6359138243788932	3	Q96IJ6,Q9Y5P6	2
+Survival motor neuron [IPR010304]	0.6991283438533207	0.7406683432058885	0.4588945582940122	1.0	0.6359138243788932	2	O75940	1
+SUN domain [IPR012919]	0.7201113773652703	0.7349697460498815	0.4623579195927552	1.0	0.6375473002884228	3	O94901	1
+Immunoglobulin subtype [IPR003599]	0.4682067343751429	0.7288184924038705	0.4661126981861931	1.0	0.6407562512585084	9	Q9Y639	1
+Immunoglobulin subtype 2 [IPR003598]	0.4682067343751429	0.7288184924038705	0.4661126981861931	1.0	0.6407562512585084	9	Q9Y639	1
+Syntaxin, N-terminal domain [IPR006011]	0.7140709561034183	0.7144132945972261	0.4749716535670969	1.0	0.6499485076505042	3	Q86Y82,O15400	2
+Proteasome alpha-subunit, N-terminal domain [IPR000426]	0.5048896297438696	0.7087329033403902	0.4784902422247099	1.0	0.6527731622650171	7	P25786	1
+Exosome complex component, N-terminal domain [IPR025721]	0.6874060715359183	0.6976458831460186	0.4853986795753848	1.0	0.65769483190654	2	Q13868	1
+Dynamin, GTPase domain [IPR001401]	0.7083583884545824	0.6951163969372178	0.4869823597555294	1.0	0.65769483190654	3	O00429,O60313	2
+Phosphoinositide 3-kinase, accessory (PIK) domain [IPR001263]	0.6273335116662428	0.6932993625895307	0.4881217029813354	1.0	0.6587201692877293	4	P42356	1
+Diacylglycerol kinase, catalytic domain [IPR001206]	0.6795912233243011	0.669410599809264	0.5032335918260855	1.0	0.6692385495247646	2	Q9NRA0	1
+Zinc finger, UBR-type [IPR003126]	0.6952070975589235	0.6512617603068821	0.5148775285492071	1.0	0.6767935402197568	3	Q8IWV7	1
+ABC transporter type 1, transmembrane domain [IPR011527]	0.5347320263376567	0.630981527554579	0.5280526027815833	1.0	0.6862937314481394	5	Q03518	1
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.4814023161272779	0.6074894615461711	0.543526134273911	1.0	0.6937708955540152	7	Q14168	1
+Guanylate kinase-like domain [IPR008144]	0.4814023161272779	0.6074894615461711	0.543526134273911	1.0	0.6937708955540152	7	Q14168	1
+SH3 domain [IPR001452]	0.3543598507315651	0.5883787032465624	0.5562781292143313	1.0	0.7021735249124722	33	P62993,Q9UQB8,Q92783,P46108,Q14168,Q9NZW5	6
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.6707757065544068	0.5721631655865278	0.5672114392862828	1.0	0.7069645171502856	3	P16615,P05023	2
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.6707757065544068	0.5721631655865278	0.5672114392862828	1.0	0.7069645171502856	3	P16615,P05023	2
+HDGF-related, PWWP domain [IPR035496]	0.6702754362583389	0.5705789474971847	0.5682850925533456	1.0	0.7069645171502856	3	P51858	1
+Cold-shock (CSD) domain [IPR019844]	0.5899146877974333	0.563362076848973	0.5731883551750578	1.0	0.7096994209133015	4	P16989	1
+Glutamine amidotransferase [IPR017926]	0.5875171571863147	0.5553065146284332	0.5786850236349088	1.0	0.7128997111842678	4	P17812	1
+NudC N-terminal domain [IPR025934]	0.6278929966937106	0.4935079246769616	0.6216537417932599	1.0	0.7390226473979638	2	Q8IVD9	1
+Band 7 domain [IPR001107]	0.4284853959650767	0.4855894758295176	0.6272582596353	1.0	0.7419125976348222	8	O94905,P35232,Q99623,O75477,O75955,Q9UJZ1,P27105	7
+Zinc finger, CCHC-type [IPR001878]	0.4157059179530634	0.4774311223815416	0.6330551567737592	1.0	0.7444618066339448	9	Q8TBF4,Q9NUD5	2
+Post-SET domain [IPR003616]	0.6324105240944986	0.4554546112883145	0.6487822142242394	1.0	0.7521181674153581	3	O96028	1
+p21 activated kinase binding domain [IPR033923]	0.6253758268189908	0.4352123743836871	0.6634082813730646	1.0	0.7647938791685202	3	Q13177,Q13153	2
+DNA-directed RNA polymerase, subunit 2, hybrid-binding domain [IPR007120]	0.60414788097384	0.4204063293832003	0.6741886451188714	1.0	0.7714496218754491	2	P30876	1
+RNA polymerase Rpb2, domain 2 [IPR007642]	0.60414788097384	0.4204063293832003	0.6741886451188714	1.0	0.7714496218754491	2	P30876	1
+RNA polymerase, beta subunit, protrusion [IPR007644]	0.60414788097384	0.4204063293832003	0.6741886451188714	1.0	0.7714496218754491	2	P30876	1
+RNA polymerase Rpb2, domain 3 [IPR007645]	0.60414788097384	0.4204063293832003	0.6741886451188714	1.0	0.7714496218754491	2	P30876	1
+RNA polymerase Rpb2, domain 7 [IPR007641]	0.60414788097384	0.4204063293832003	0.6741886451188714	1.0	0.7714496218754491	2	P30876	1
+Phosphatidylinositol 3-/4-kinase, catalytic domain [IPR000403]	0.4358200485677166	0.4202017652473448	0.6743380653155615	1.0	0.7714496218754491	7	P42356	1
+CRIB domain [IPR000095]	0.4742845401369182	0.4120927136027575	0.6802714691115008	1.0	0.7758474232711965	5	Q9Y5S2	1
+ABC transporter-like, ATP-binding domain [IPR003439]	0.4012703803566901	0.4115558702285614	0.680664982620439	1.0	0.7758474232711965	9	Q03518	1
+BAG domain [IPR003103]	0.5407414367715864	0.4063509678510131	0.684484741133907	1.0	0.7771110631567604	4	O95429,Q9UL15	2
+Ubiquitin system component CUE [IPR003892]	0.540451127819552	0.4054813512410884	0.6851237236502394	1.0	0.7771110631567604	4	Q9H1I8,Q9H4L7,Q9Y679	3
+Glycosyltransferase 2-like [IPR001173]	0.4660048134777331	0.3843960323301021	0.7006849408081743	1.0	0.7894796221673963	5	Q10471,O60762,Q10472,Q9Y673	4
+Heat shock protein DnaJ, cysteine-rich domain [IPR001305]	0.5923030667468328	0.3456251747601633	0.7296244239449428	1.0	0.8122689432342831	3	O60884,P31689	2
+14-3-3 domain [IPR023410]	0.4363526933493882	0.3443635797575755	0.7305728749219027	1.0	0.812988740563919	6	P61981,P27348,P63104,P62258,Q04917	5
+Alpha-ketoglutarate-dependent dioxygenase AlkB-like [IPR027450]	0.5728884881274502	0.3332173867900494	0.7389701946159715	1.0	0.8189492732925149	2	Q6P6C2	1
+NUC153 [IPR012580]	0.5713856327021393	0.3293080992778094	0.7419228228882553	1.0	0.8208702391282134	2	Q9BSC4	1
+Tim10-like [IPR004217]	0.585387853277199	0.328149659886454	0.7427985077552739	1.0	0.8215015939979271	3	Q9Y5J9,O60220	2
+Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]	0.5704839194469524	0.3269755281669845	0.7436863944695427	1.0	0.822145919666042	2	Q9H993	1
+FKBP3, basic tilted helix bundle domain [IPR041200]	0.5680793507664645	0.3208032809614817	0.7483594728646439	1.0	0.826972531975579	2	Q00688	1
+EF-hand, Ca insensitive [IPR014837]	0.5091729323308305	0.3164590793867615	0.7516540802656648	1.0	0.8302725341080539	4	Q13813,P12814,O43707	3
+MRH domain [IPR044865]	0.5782946962176396	0.310707794007214	0.7560227715757175	1.0	0.8336155772628934	3	P20645	1
+LEM-like domain [IPR013146]	0.5626690712353516	0.3071732242286506	0.7587115249215142	1.0	0.835995925326405	2	P42167	1
+Amine oxidase [IPR002937]	0.5765859940852004	0.3065808077765676	0.7591624637687324	1.0	0.835995925326405	3	Q8NB78	1
+Sterile alpha motif domain [IPR001660]	0.4336340545080198	0.2829890122104582	0.7771852598704037	1.0	0.848382612416294	5	Q9Y6Y8	1
+AMPK, C-terminal adenylate sensor domain [IPR032270]	0.5524496543432542	0.2824189545982453	0.7776222826380255	1.0	0.8485157241265002	2	P54646	1
+Ricin B, lectin domain [IPR000772]	0.4310070504322283	0.2752883493808228	0.7830947146566181	1.0	0.8524147399233114	5	Q9UBG0	1
+LsmAD domain [IPR009604]	0.5422302374511628	0.2589923864702873	0.795641114846213	1.0	0.8628165285215537	2	Q99700	1
+Ataxin 2, SM domain [IPR025852]	0.5422302374511628	0.2589923864702873	0.795641114846213	1.0	0.8628165285215537	2	Q99700	1
+Heat shock protein Hsp90, N-terminal [IPR020575]	0.4769924812030113	0.2356555207535914	0.8136999871484265	1.0	0.8786263293467171	4	P08238,P14625,P07900	3
+JAB1/MPN/MOV34 metalloenzyme domain [IPR000555]	0.3647355056095712	0.2251695997447675	0.8218473380877815	1.0	0.8831743341861116	8	O95630	1
+Hotdog acyl-CoA thioesterase (ACOT)-type domain [IPR033120]	0.5220919747520364	0.2168268611676998	0.8283432777153892	1.0	0.8883824957736133	2	O00154	1
+NECAP, PHear domain [IPR012466]	0.5202885482416645	0.2133137856710872	0.8310822215892155	1.0	0.8906105940070662	2	Q9NVZ3	1
+Cysteine-rich flanking region, C-terminal [IPR000483]	0.5124737000300634	0.1985941866663079	0.8425802014049295	1.0	0.9018555176404908	2	Q13641	1
+Leucine-rich repeat N-terminal domain [IPR000372]	0.5124737000300634	0.1985941866663079	0.8425802014049295	1.0	0.9018555176404908	2	Q13641	1
+IMP dehydrogenase/GMP reductase [IPR001093]	0.508265704839207	0.1910077773588506	0.8485194998911771	1.0	0.9039015083888212	2	P12268	1
+Alpha-D-phosphohexomutase, C-terminal [IPR005843]	0.5070634204989469	0.188883896383885	0.8501838152107271	1.0	0.9053163362445584	2	O95394	1
+JmjC domain [IPR003347]	0.36751424547723	0.1778488350715698	0.858841693816967	1.0	0.9120113097196736	7	Q9H6W3	1
+Chromo shadow domain [IPR008251]	0.5132291040288572	0.1755625515122462	0.8606376248785399	1.0	0.9131982363269928	3	Q13185,P45973	2
+Chromo domain subgroup [IPR017984]	0.5132291040288572	0.1755625515122462	0.8606376248785399	1.0	0.9131982363269928	3	Q13185,P45973	2
+DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]	0.4959422903516644	0.1701561649840887	0.8648873241983186	1.0	0.9155430676360344	2	O15160	1
+DNA-directed RNA polymerase, insert domain [IPR011262]	0.4959422903516644	0.1701561649840887	0.8648873241983186	1.0	0.9155430676360344	2	O15160	1
+HTH CenpB-type DNA-binding domain [IPR006600]	0.4950405770964909	0.1687101183338281	0.8660246595923073	1.0	0.9160268689246204	2	Q7Z3K3	1
+DDE superfamily endonuclease domain [IPR004875]	0.4950405770964909	0.1687101183338281	0.8660246595923073	1.0	0.9160268689246204	2	Q7Z3K3	1
+SET domain [IPR001214]	0.3883865503155594	0.1631315474094617	0.8704148612504394	1.0	0.9199478890688514	5	O96028	1
+Zinc finger, LIM-type [IPR001781]	0.3372513562387143	0.1536340860789716	0.877898259194543	1.0	0.9249306825626976	11	Q9UHB6,Q53GG5,Q16527,Q96HC4,Q8N3F8,Q9UGI8,Q14847,Q9NR12,Q15942,Q13642	10
+Peroxiredoxin, C-terminal [IPR019479]	0.4301322558726993	0.1404265663657539	0.8883229688911054	1.0	0.9335061365232284	4	P30048	1
+Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]	0.4301322558726993	0.1404265663657539	0.8883229688911054	1.0	0.9335061365232284	4	P30048	1
+EF hand associated, type-2 [IPR013567]	0.4676886083558834	0.129915351607464	0.8966333983992543	1.0	0.9399119275551544	2	Q8IXI2	1
+MIRO domain [IPR020860]	0.4676886083558834	0.129915351607464	0.8966333983992543	1.0	0.9399119275551544	2	Q8IXI2	1
+EF hand associated, type-1 [IPR013566]	0.4676886083558834	0.129915351607464	0.8966333983992543	1.0	0.9399119275551544	2	Q8IXI2	1
+BAT2, N-terminal [IPR009738]	0.4780517137702758	0.1223514454766719	0.9026206904108574	1.0	0.9439835026316268	3	Q5JSZ5,P48634	2
+Kinesin-like [IPR022164]	0.4595731890592231	0.1202410844909098	0.9042921731307204	1.0	0.9453644496277288	2	O60333	1
+R3H domain [IPR001374]	0.4759470835838696	0.1196130697196465	0.9047896659219774	1.0	0.945517489455912	3	Q9H6S0,O95453	2
+Sec63 domain [IPR004179]	0.474443776307868	0.117687331755869	0.906315404813924	1.0	0.9467445248890214	3	Q9UGP8,Q8N3C0	2
+Rhodanese-like domain [IPR001763]	0.4132330827067707	0.1130219290844471	0.9100131697110564	1.0	0.9495023115195176	4	P25325,Q99956,Q8NCN5	3
+N-acetylgalactosaminyltransferase [IPR045885]	0.4657245941070276	0.1070107575886526	0.9147804454415568	1.0	0.9530566015748696	3	Q10471,Q10472	2
+Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain [IPR019564]	0.46452194828623	0.1056034977711625	0.9158969494525668	1.0	0.9530566015748696	3	Q13505,O75431	2
+Metaxin, glutathione S-transferase domain [IPR033468]	0.46452194828623	0.1056034977711625	0.9158969494525668	1.0	0.9530566015748696	3	Q13505,O75431	2
+SCP2 sterol-binding domain [IPR003033]	0.4530968129885582	0.0930095813536375	0.9258959494014936	1.0	0.959383528948912	3	P51659,Q6YN16	2
+v-SNARE, coiled-coil homology domain [IPR042855]	0.4515935057125729	0.0914553508159898	0.9271307823860122	1.0	0.9599243356268862	3	O15498,O75396	2
+Longin domain [IPR010908]	0.4515935057125729	0.0914553508159898	0.9271307823860122	1.0	0.9599243356268862	3	O15498,O75396	2
+Glycoside hydrolase family 31, N-terminal domain [IPR025887]	0.4283137962127976	0.0902212948187578	0.9281113625161486	1.0	0.9604649738404136	2	P10253	1
+SAM domain [IPR041418]	0.4253080853621933	0.0878986465545212	0.929957232335216	1.0	0.9610033870601448	2	Q9NZI7	1
+CP2 transcription factor [IPR007604]	0.4253080853621933	0.0878986465545212	0.929957232335216	1.0	0.9610033870601448	2	Q9NZI7	1
+Transcription factor CBF/NF-Y/archaeal histone domain [IPR003958]	0.447553215688742	0.0873944153826197	0.9303580082747908	1.0	0.9610487596026128	3	Q9NR33	1
+CTLH/CRA C-terminal to LisH motif domain [IPR024964]	0.423631990378835	0.0666804465097465	0.946836101085858	1.0	0.9748330901771224	3	Q9H871,Q9NWU2	2
+CRA domain [IPR013144]	0.423631990378835	0.0666804465097465	0.946836101085858	1.0	0.9748330901771224	3	Q9H871,Q9NWU2	2
+GINS subunit, domain A [IPR021151]	0.377817853922444	0.0620312337297699	0.9505379589682944	1.0	0.9777688019486696	2	Q9BRT9	1
+Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain [IPR004099]	0.4107035478051607	0.0576987224443023	0.9539886113444018	1.0	0.9805692100574328	3	Q16881,P09622	2
+Ataxin-2, C-terminal [IPR009818]	0.3294223826714804	0.0523655100104603	0.9582374554192998	1.0	0.9845606514476056	5	Q9BPZ3,Q9H074,Q8WWM7,Q99700	4
+CS domain [IPR007052]	0.3075484212684653	0.0509631657588299	0.9593548718534732	1.0	0.9845818101758396	9	Q9HB71,Q9P035,Q15185,Q96RS6,Q8IVD9	5
+Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type [IPR003617]	0.3971737823211123	0.0497973489013412	0.960283879334197	1.0	0.9847846485327466	3	Q96QC0,P23193	2
+PTBP1, RNA recognition motif 2-like [IPR021790]	0.3536842105263198	0.0449537479890179	0.9641441754133904	1.0	0.9872396442540914	4	Q8WVV9,Q9UKA9,P14866	3
+DZF domain [IPR006561]	0.3518796992481244	0.0435299223444525	0.9652791125440844	1.0	0.9880260927712732	4	Q96SI9,Q96KR1,Q12906	3
+TRIAD supradomain [IPR044066]	0.3728915062048832	0.038987208700974	0.9689005868388638	1.0	0.9901939127347742	3	Q9UBS8	1
+IBR domain [IPR002867]	0.3728915062048832	0.038987208700974	0.9689005868388638	1.0	0.9901939127347742	3	Q9UBS8	1
+Exoribonuclease, phosphorolytic domain 2 [IPR015847]	0.2873044524669121	0.0052616394856671	0.9958018384607964	1.0	1.0	5	Q8TCS8,Q15024,Q9NQT4,Q96B26	4
+Immunoglobulin I-set [IPR013098]	0.2348118531515099	0.0035398720705365	0.9971755966263254	1.0	1.0	4	P10586	1

interpro_family/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome, subunit alpha/beta [IPR001353]"}