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interpro_active_site/advanced/idx2term.json

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+{}

interpro_active_site/basic/idx2term.json

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+{}

interpro_active_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:9ea14ea98e11fdd8a6faeb8c2905d122f7e33c46ccc44296575112d721947fc4
+size 68132

interpro_active_site/df_merge.tsv

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+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_active_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2812,
+    "annotations_size": 55,
+    "title": "Average number of proteins per term",
+    "value": 2.3454545454545452
+}

interpro_active_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_active_site/fragment/C428/C428_val_log2fc"}

interpro_active_site/result.tsv

@@ -0,0 +1,6 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Histidine acid phosphatase active site [IPR033379]	0.8928825622775785	1.5159951898078918	0.1295205687158602	0.9995139082554834	0.2968179699738464	2	P11117	1
+Protein-tyrosine phosphatase, active site [IPR016130]	0.7264643457319988	1.379102104557932	0.1678632750731459	0.999959195514136	0.3419437084823342	5	Q9Y217,Q06124	2
+Serine carboxypeptidase, serine active site [IPR018202]	0.907636865836474	1.335365276180793	0.1817568237829161	0.9999838366428432	0.3515804655167711	3	Q9HB40	1
+Peptidase S9, serine active site [IPR002471]	0.6658362989323828	0.615995171564202	0.5378977065544421	1.0	0.7396093465123579	2	P48147	1
+ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]	0.4330960854092507	0.0707980076245964	0.9435585175327748	1.0	0.9757082046299924	2	P53597	1

interpro_active_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["ATP-citrate lyase/succinyl-CoA ligase, active site [IPR017440]", "ATP:guanido phosphotransferase active site [IPR022415]", "ATPase, alpha/beta subunit, nucleotide-binding domain, active site [IPR020003]", "Adenosine/AMP deaminase active site [IPR006650]", "Adenylosuccinate synthase,  active site [IPR033128]", "Beta-ketoacyl synthase, active site [IPR018201]", "Citrate synthase active site [IPR019810]", "ClpP, Ser active site [IPR018215]", "ClpP, histidine active site [IPR033135]", "Coenzyme A transferase active site [IPR004164]", "Cysteine peptidase, asparagine active site [IPR025661]", "Cysteine peptidase, cysteine active site [IPR000169]", "Cysteine peptidase, histidine active site [IPR025660]", "DNA methylase, C-5 cytosine-specific, active site [IPR018117]", "DNA topoisomerase I, active site [IPR018521]", "Ferrochelatase, active site [IPR019772]", "Glucose-6-phosphate dehydrogenase, active site [IPR019796]", "Glutaredoxin active site [IPR011767]", "Glyceraldehyde 3-phosphate dehydrogenase, active site [IPR020830]", "Glycoside hydrolase, family 2, active site [IPR023232]", "Glycosyl hydrolases family 31, active site [IPR030458]", "Histidine acid phosphatase active site [IPR033379]", "Hydroxymethylglutaryl-coenzyme A synthase, active site [IPR000590]", "L-lactate dehydrogenase, active site [IPR018177]", "Leu/Phe/Val dehydrogenases active site [IPR033524]", "Malate dehydrogenase, active site [IPR001252]", "Nucleoside diphosphate kinase, active site [IPR023005]", "Orotidine 5'-phosphate decarboxylase, active site [IPR018089]", "Peptidase S16, active site [IPR008268]", "Peptidase S26A, signal peptidase I, serine active site [IPR019756]", "Peptidase S8, subtilisin, His-active site [IPR022398]", "Peptidase S8, subtilisin, Ser-active site [IPR023828]", "Peptidase S9, serine active site [IPR002471]", "Phosphoglycerate/bisphosphoglycerate mutase, active site [IPR001345]", "Phosphoribosylglycinamide formyltransferase, active site [IPR001555]", "Protein-tyrosine phosphatase, active site [IPR016130]", "Pyridine nucleotide-disulphide oxidoreductase, class I, active site [IPR012999]", "Pyruvate kinase, active site [IPR018209]", "Ribonuclease T2, His active site 1 [IPR018188]", "Ribonuclease T2, His active site 2 [IPR033130]", "Ribonucleotide reductase small subunit, acitve site [IPR030475]", "Serine carboxypeptidase, serine active site [IPR018202]", "Serine carboxypeptidases, histidine active site [IPR033124]", "Serine proteases, trypsin family, histidine active site [IPR018114]", "Serine/threonine-protein kinase, active site [IPR008271]", "Thermonuclease active site [IPR002071]", "Thiolase, active site [IPR020610]", "Thiolase, acyl-enzyme intermediate active site [IPR020615]", "Thymidylate synthase, active site [IPR020940]", "Transaldolase, active site [IPR018225]", "Triosephosphate isomerase, active site [IPR020861]", "Tyrosine-protein kinase, active site [IPR008266]", "Ubiquitin-activating enzyme E1, Cys active site [IPR033127]", "Ubiquitin-conjugating enzyme, active site [IPR023313]", "Uracil-DNA glycosylase, active site [IPR018085]"], "available_proteins": ["ACAA2", "ACAT1", "ACAT2", "ACLY", "ACP2", "ACP6", "ADSS", "AKT2", "AMPD2", "APEH", "ATP5A1", "ATP5B", "ATP6V1A", "ATP6V1B2", "BLMH", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK11B", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "CHEK2", "CKB", "CKMT1A*", "CLPP", "CPVL", "CS", "CSK", "CSNK1A1", "CSNK2A2", "CTSA", "CTSB", "CTSC", "DLD", "DNMT1", "DUSP3", "EIF2AK2", "FASN", "FECH", "G6PD", "GAA", "GAK", "GANAB", "GAPDH", "GART", "GLRX", "GLUD1", "GSR", "GUSB", "HADHB", "HMGCS1", "IGF1R", "LDHA", "LDHB", "LONP1", "MAP2K1", "MAP2K4", "MAPK1", "MDH1", "MDH2", "MTMR6", "NEK9", "NME1", "OXCT1", "PAK2", "PBK", "PGAM1", "PIK3R4", "PKM", "PKN2", "PLK1", "PREP", "PRKAA1", "PRKACA", "PRKCB", "PRPF4B", "PRSS3", "PTK7", "PTPN1", "PTPN11", "PTPRF", "RIPK1", "RNASET2", "ROCK1", "RPS6KA1", "RPS6KA3", "RRM2", "SCP2", "SCPEP1", "SEC11A", "SLK", "SND1", "SRPK1", "SUCLG1", "TALDO1", "TAOK1", "TIGAR", "TOP1", "TPI1", "TPP2", "TXNRD1", "TXNRD2", "TYMS", "UBA1", "UBA2", "UBA3", "UBE2K", "UBE2L3", "UBE2M", "UBE2S", "UMPS", "UNG", "VRK1", "WNK1"], "leading_proteins": ["ACP2", "MTMR6", "PREP", "PTPN11", "SCPEP1", "SUCLG1"]}

interpro_binding_site/advanced/idx2term.json

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+{}

interpro_binding_site/basic/idx2term.json

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+{"0": "EF-Hand 1, calcium-binding site [IPR018247]"}

interpro_binding_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:1e77922de6d9c59b1775826248b7a7b73d77f41a858e5e802fe89835de5f89fb
+size 65516

interpro_binding_site/df_merge.tsv

@@ -0,0 +1 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500

interpro_binding_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2812,
+    "annotations_size": 31,
+    "title": "Average number of proteins per term",
+    "value": 3.806451612903226
+}

interpro_binding_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_binding_site/fragment/C428/C428_val_log2fc"}

interpro_binding_site/result.tsv

@@ -0,0 +1,3 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Beta tubulin, autoregulation binding site [IPR013838]	0.8063443746058448	1.3035067198458916	0.1924018237166755	0.9986724367670954	0.3599957918437211	4	Q9BVA1,P07437	2
+EF-Hand 1, calcium-binding site [IPR018247]	0.2763703116266652	0.1461982747724726	0.8837648674602605	1.0	0.9447141686644164	32	Q14257,O43852,Q96D71,P80303,Q9H223	5

interpro_binding_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["2-oxo acid dehydrogenase, lipoyl-binding site [IPR003016]", "2Fe-2S ferredoxin, iron-sulphur binding site [IPR006058]", "6-phosphogluconate-binding site [IPR006184]", "AP endonuclease 1, binding site [IPR020847]", "APOBEC/CMP deaminase, zinc-binding [IPR016192]", "Aconitase family, 4Fe-4S cluster binding site [IPR018136]", "Adenylosuccinate synthase, GTP-binding site [IPR018220]", "Aminotransferase class-V, pyridoxal-phosphate binding site [IPR020578]", "Aminotransferase, class-II, pyridoxal-phosphate binding site [IPR001917]", "Aminotransferases, class-I, pyridoxal-phosphate-binding site [IPR004838]", "Beta tubulin, autoregulation binding site [IPR013838]", "Biotin-binding site [IPR001882]", "Coenzyme A transferase binding site [IPR004163]", "Copper centre Cu(A) [IPR001505]", "Cytochrome b5, heme-binding site [IPR018506]", "Cytochrome c oxidase, subunit Vb, zinc binding site [IPR020893]", "EF-Hand 1, calcium-binding site [IPR018247]", "Fumarate reductase/succinate dehydrogenase, FAD-binding site [IPR003952]", "Hexokinase, binding site [IPR019807]", "IQ motif, EF-hand binding site [IPR000048]", "Inositol monophosphatase, metal-binding site [IPR020583]", "Manganese/iron superoxide dismutase, binding site [IPR019833]", "PPM-type phosphatase, divalent cation binding [IPR000222]", "Peptidase M16, zinc-binding site [IPR001431]", "Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site [IPR018349]", "Porphobilinogen deaminase, dipyrromethane cofactor binding site [IPR022419]", "Protein kinase, ATP binding site [IPR017441]", "Serine hydroxymethyltransferase, pyridoxal phosphate binding site [IPR019798]", "Sigma-54 interaction domain, ATP-binding site 1 [IPR025662]", "Transketolase binding site [IPR020826]", "Ureohydrolase, manganese-binding site [IPR020855]"], "available_proteins": ["ACACA", "ACO1", "ACO2", "ACTN1", "ACTN4", "ADSS", "AKT2", "APEX1", "APOBEC3C", "ARG2", "BPNT1", "CALU", "CAMK2G", "CAPN1", "CAPN2", "CDK1", "CDK12", "CDK13", "CDK2", "CDK4", "CDK5", "COX2", "COX5B", "CSK", "CSNK1A1", "CSNK2A2", "CYB5B", "DBT", "DLAT", "DLST", "EHD1", "EHD4", "EIF2AK2", "EPS15", "EPS15L1", "FKBP10", "GCAT", "GOT1", "GOT2", "GPD2", "HK1", "HK2", "HMBS", "IDE", "IGF1R", "ILKAP", "IQGAP1", "IQGAP2", "IQSEC1", "LETM1", "MACF1", "MAP2K1", "MAP2K4", "MAPK1", "MAPK14", "MCCC1", "MICU1", "MYH10", "MYH9", "MYO1B", "MYO1C", "MYO1D", "NRDC", "NUCB1", "NUCB2", "OXCT1", "PA2G4", "PAK2", "PC", "PCCA", "PDCD6", "PEF1", "PGD", "PKN2", "PLCG1", "PLK1", "PLS1", "PLS3", "PMPCA", "PMPCB", "PPM1F", "PPM1G", "PRKAA1", "PRKACA", "PRKCB", "PRKCSH", "PSAT1", "RAB18", "RCN1", "RCN2", "REPS1", "RHOT1", "RHOT2", "ROCK1", "RPS6KA1", "RPS6KA3", "S100A11", "SDHA", "SDHB", "SHMT2", "SLC25A12", "SLC25A24", "SLK", "SOD2", "SPTAN1", "SPTLC2", "SRI", "SRPK1", "TAOK1", "TBK1", "TKT", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "UBE3C", "UQCRC2", "VRK1"], "leading_proteins": ["CALU", "EHD4", "NUCB2", "RCN2", "REPS1", "TUBB", "TUBB2B"]}

interpro_conserved_site/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "Zinc finger, RING-type, conserved site [IPR017907]"}

interpro_conserved_site/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome beta-type subunit, conserved site [IPR016050]", "1": "Zinc finger, RING-type, conserved site [IPR017907]", "2": "14-3-3 protein, conserved site [IPR023409]"}

interpro_conserved_site/consensus.joblib

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+version https://git-lfs.github.com/spec/v1
+oid sha256:224d58dabdfefd28dde5ebf817ffaf891b605c290e5150729130a0df2052b159
+size 87044

interpro_conserved_site/df_merge.tsv

@@ -0,0 +1,3 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+Proteasome beta-type subunit, conserved site [IPR016050]	6	8	2.6144405821107077	0.0089373704314283	3.7135922330097086	7.970873786407767	1.4913184573846054	0.1902243906475925	1.515457478026574	0.1681602725795027	1.0170822776023185	0.2455850375425174	3.5930470170495774e-05	0.0010343090391069	9.839858993160587e-05	3.59582749836129e-08	6.442496475603332e-08
+Zinc finger, RING-type, conserved site [IPR017907]	7	14	1.965327334116363	0.0493763638823894	4.609223300970874	14.776699029126211	-0.045326225777209	0.5577732895844865	3.238903742779499	4.550007017672923	0.8841385018499901	0.2924846286854669	1.0	1.0	1.0	0.9161766745136084	0.8745957259037637

interpro_conserved_site/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2812,
+    "annotations_size": 259,
+    "title": "Average number of proteins per term",
+    "value": 2.6563706563706564
+}

interpro_conserved_site/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_conserved_site/fragment/C428/C428_val_log2fc"}

interpro_conserved_site/result.tsv

@@ -0,0 +1,29 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+Proteasome beta-type subunit, conserved site [IPR016050]	0.8873246927674877	2.6144405821107073	0.0089373704314283	0.9022346450425428	0.0845387370726674	8	P28074,P20618,Q99436,P28072,P28070,P49721	6
+Zinc finger, RING-type, conserved site [IPR017907]	0.6248655100810386	1.965327334116363	0.0493763638823894	0.9999979852110934	0.2131413040923143	14	O15344,Q5VTR2,Q9H000,Q99496,P19474,Q14258,Q9UBS8	7
+Haem oxygenase conserved site [IPR018207]	0.972241992882564	1.841192043332856	0.0655934209443853	0.999999976622671	0.2654483753843095	2	P30519	1
+Glycoside hydrolase, family 35, conserved site [IPR019801]	0.9434163701067636	1.7234980663625985	0.0847984945480808	0.999999999892147	0.3179255134861725	2	Q8IW92	1
+Guanylate kinase, conserved site [IPR020590]	0.8615887284167849	1.515047308890242	0.1297604238773468	0.9999999999999998	0.3819085202753732	4	Q14168,O14936	2
+Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]	0.9401922392310432	1.454826982285097	0.1457171663124929	1.0	0.3964138717367543	3	P55899,P04439	2
+Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]	0.8390366092740751	1.4288214842023483	0.1530555489331098	1.0	0.3964138717367543	4	P48735	1
+Glycoside hydrolase, family 29, conserved site [IPR018526]	0.8594306049822151	1.378332726868318	0.1681005832940041	1.0	0.4234385222086269	2	Q9BTY2	1
+Thioredoxin, conserved site [IPR017937]	0.5797640670401556	1.3652473246497838	0.1721753287319991	1.0	0.4234385222086269	10	O95881	1
+Profilin conserved site [IPR027310]	0.8558718861209968	1.3636977697953243	0.1726627062654804	1.0	0.4234385222086269	2	P35080	1
+Tubulin, conserved site [IPR017975]	0.8063443746058448	1.3035067198458916	0.1924018237166755	1.0	0.4429462349575486	4	Q9BVA1,P07437	2
+Ubiquitin interacting motif [IPR003903]	0.898685211187423	1.3025301025720954	0.1927352344036359	1.0	0.4429462349575486	3	Q92783	1
+DnaJ domain, conserved site [IPR018253]	0.5785541390239369	1.2627219309347624	0.2066891296360524	1.0	0.4589911306384225	9	Q99543,O60884	2
+Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]	0.6969913132754599	0.8874763096982349	0.3748225152468571	1.0	0.655939401682	4	P42356,P42345	2
+Ubiquitin specific protease, conserved site [IPR018200]	0.432751396353463	0.8223687509824515	0.4108670587290803	1.0	0.6777997975212218	14	Q96K76,Q9UPU5,Q8TEY7,Q96RU2	4
+Sugar transporter, conserved site [IPR005829]	0.6885582362252703	0.565748582689084	0.57156470399169	1.0	0.7774724948205761	3	Q5SR56	1
+Annexin repeat, conserved site [IPR018252]	0.4481152811367704	0.5219084417124175	0.601734080403064	1.0	0.7871168021434019	7	P50995,P04083	2
+14-3-3 protein, conserved site [IPR023409]	0.4354953670705573	0.3889432256894514	0.6973181452731891	1.0	0.8282584517582144	6	P31946,P61981,P62258,P63104,Q04917	5
+Phosphorylase pyridoxal-phosphate attachment site [IPR035090]	0.5914590747330902	0.3736200512772922	0.7086870138387349	1.0	0.8329389358276973	2	P06737	1
+Heat shock protein Hsp90, conserved site [IPR019805]	0.573474852456086	0.2499077058366811	0.8026587238781326	1.0	0.889356803448252	3	P14625	1
+Fumarate lyase, conserved site [IPR020557]	0.4765124555160116	0.1212182236464325	0.9035181901715184	1.0	0.9710008765743704	2	P07954	1
+DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]	0.4608540925266834	0.1003337346565336	0.920079376227837	1.0	0.9742297109840388	2	P19387	1
+ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]	0.4330960854092507	0.0707980076245964	0.9435585175327748	1.0	0.9831336931348345	2	P53597	1
+Zinc finger, PHD-type, conserved site [IPR019786]	0.2781690072860034	0.0520406584197719	0.9584962965545178	1.0	0.9890459793132276	15	O96028	1
+HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]	0.3807829181494704	0.0371839121405647	0.9703383659936112	1.0	0.9921212944871114	2	P52926	1
+Intermediate filament protein, conserved site [IPR018039]	0.3250450491084149	0.0263915572335404	0.978945028157653	1.0	0.9943010285993416	5	P08670	1
+Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]	0.290391459074739	0.019850284973368	0.984162804164154	1.0	0.994693267133942	2	P13995	1
+AT hook, DNA-binding motif [IPR017956]	0.3741545033819922	0.0114646256399731	0.9908527525890234	1.0	0.994693267133942	3	P52926,P17096	2

interpro_conserved_site/selections.json

@@ -0,0 +1 @@
+{"all_annotations": ["14-3-3 protein, conserved site [IPR023409]", "3-hydroxyacyl-CoA dehydrogenase, conserved site [IPR006180]", "3-hydroxyisobutyrate dehydrogenase-related, conserved site [IPR002204]", "4Fe-4S ferredoxin, iron-sulphur binding, conserved site [IPR017900]", "ABC transporter-like, conserved site [IPR017871]", "AMP-binding, conserved site [IPR020845]", "AP endonuclease 1, conserved site [IPR020848]", "AT hook, DNA-binding motif [IPR017956]", "ATP synthase, F1 complex, gamma subunit conserved site [IPR023632]", "ATP-citrate lyase/succinyl-CoA ligase, conserved site [IPR033847]", "ATP-dependent RNA helicase DEAD-box, conserved site [IPR000629]", "ATPase, AAA-type, conserved site [IPR003960]", "ATPase, OSCP/delta subunit, conserved site [IPR020781]", "Acin1, RNSP1-SAP18 binding (RSB) motif [IPR032552]", "Actin, conserved site [IPR004001]", "Actin/actin-like conserved site [IPR020902]", "Actinin-type actin-binding domain, conserved site [IPR001589]", "Acyl-CoA dehydrogenase, conserved site [IPR006089]", "Acyl-CoA-binding protein, ACBP, conserved site [IPR022408]", "Adenylate kinase, conserved site [IPR033690]", "Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 [IPR008142]", "Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 [IPR008143]", "Alcohol dehydrogenase, zinc-type, conserved site [IPR002328]", "Aldehyde dehydrogenase, cysteine active site [IPR016160]", "Aldehyde dehydrogenase, glutamic acid active site [IPR029510]", "Aldo/keto reductase, conserved site [IPR018170]", "Aldose 1-epimerase, conserved site [IPR018052]", "Alpha-D-phosphohexomutase, conserved site [IPR016066]", "Aminoacyl-tRNA synthetase, class I, conserved site [IPR001412]", "Amyloidogenic glycoprotein,  copper-binding domain conserved site [IPR019744]", "Amyloidogenic glycoprotein, intracellular domain, conserved site [IPR019745]", "Annexin repeat, conserved site [IPR018252]", "Apoptosis regulator, Bcl-2, BH1 motif, conserved site [IPR020717]", "Apoptosis regulator, Bcl-2, BH2 motif, conserved site [IPR020726]", "Apoptosis regulator, Bcl-2, BH3 motif, conserved site [IPR020728]", "ArgE/DapE/ACY1/CPG2/YscS, conserved site [IPR001261]", "BUD31/G10-related, conserved site [IPR018230]", "Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site [IPR018314]", "Bromodomain, conserved site [IPR018359]", "C-type lectin, conserved site [IPR018378]", "CAP, conserved site, C-terminal [IPR028417]", "CAP, conserved site, N-terminal [IPR018106]", "CBX family C-terminal motif [IPR033773]", "Cadherin conserved site [IPR020894]", "Calreticulin/calnexin, conserved site [IPR018124]", "Carbohydrate/purine kinase, PfkB, conserved site [IPR002173]", "Chaperonin Cpn60, conserved site [IPR018370]", "Chaperonin GroES, conserved site [IPR018369]", "Chaperonin TCP-1, conserved site [IPR002194]", "Chromo domain, conserved site [IPR023779]", "Clathrin adaptor complex, small chain [IPR000804]", "Clathrin adaptor, mu subunit, conserved site [IPR018240]", "Coproporphyrinogen III oxidase, conserved site [IPR018375]", "Cullin, conserved site [IPR016157]", "Cyclic nucleotide-binding, conserved site [IPR018488]", "Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site [IPR020892]", "Cytochrome P450, conserved site [IPR017972]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 [IPR029752]", "D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site [IPR029753]", "DNA ligase, ATP-dependent, conserved site [IPR016059]", "DNA methylase, C-5 cytosine-specific,  conserved site [IPR031303]", "DNA methylase, N-6 adenine-specific, conserved site [IPR002052]", "DNA topoisomerase, type IIA, conserved site [IPR018522]", "DNA-directed DNA polymerase, family B, conserved site [IPR017964]", "DNA-directed RNA polymerase, 30-40kDa subunit, conserved site [IPR001514]", "DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site [IPR002464]", "Dihydrofolate reductase conserved site [IPR017925]", "Dihydroorotase, conserved site [IPR002195]", "DnaJ domain, conserved site [IPR018253]", "Dynamin, GTPase region, conserved site [IPR019762]", "Dynein light chain, type 1/2, conserved site [IPR019763]", "EGF-like calcium-binding, conserved site [IPR018097]", "EGF-like, conserved site [IPR013032]", "Electron transfer flavoprotein subunit alpha, conserved site [IPR018206]", "Electron transfer flavoprotein, beta-subunit, conserved site [IPR000049]", "Enolase, conserved site [IPR020809]", "Enoyl-CoA hydratase/isomerase, conserved site [IPR018376]", "F-actin capping protein, alpha subunit, conserved site [IPR017865]", "F-actin capping protein, beta subunit, conserved site [IPR019771]", "FERM conserved site [IPR019747]", "Fatty acid desaturase type 1, conserved site [IPR001522]", "Fibrillarin, conserved site [IPR020813]", "Formate-tetrahydrofolate ligase, FTHFS, conserved site [IPR020628]", "Fructose-bisphosphate aldolase class-I active site [IPR029768]", "Fumarate lyase, conserved site [IPR020557]", "GHMP kinase, ATP-binding, conserved site [IPR006203]", "GTP1/OBG, conserved site [IPR006074]", "Galactokinase, conserved site [IPR019741]", "Gamma-glutamyl phosphate reductase GPR, conserved site [IPR020593]", "Glucosamine-6-phosphate isomerase, conserved site [IPR018321]", "Glutamate 5-kinase, conserved site [IPR019797]", "Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site [IPR017958]", "Glutathione peroxidase conserved site [IPR029760]", "Glycoside hydrolase family 27/36, conserved site [IPR000111]", "Glycoside hydrolase, family 2, conserved site [IPR023230]", "Glycoside hydrolase, family 29, conserved site [IPR018526]", "Glycoside hydrolase, family 35, conserved site [IPR019801]", "Glycosyl hydrolases family 31, conserved site [IPR030459]", "Glyoxalase I, conserved site [IPR018146]", "Guanine-nucleotide dissociation stimulator, CDC24, conserved site [IPR001331]", "Guanylate kinase, conserved site [IPR020590]", "HIND motif [IPR045347]", "HMG box A DNA-binding domain, conserved site [IPR017967]", "HMG-I/HMG-Y, DNA-binding, conserved site [IPR000637]", "Haem oxygenase conserved site [IPR018207]", "Heat shock protein 70, conserved site [IPR018181]", "Heat shock protein Hsp90, conserved site [IPR019805]", "Helix-hairpin-helix motif, class 2 [IPR008918]", "Hexapeptide transferase, conserved site [IPR018357]", "Histidine triad, conserved site [IPR019808]", "Histone H2A conserved site [IPR032458]", "Histone H4, conserved site [IPR019809]", "Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site [IPR023076]", "IMP dehydrogenase / GMP reductase, conserved site [IPR015875]", "Immunoglobulin/major histocompatibility complex, conserved site [IPR003006]", "Inositol monophosphatase, conserved site [IPR020550]", "Intermediate filament protein, conserved site [IPR018039]", "Isocitrate/isopropylmalate dehydrogenase, conserved site [IPR019818]", "Kinesin motor domain, conserved site [IPR019821]", "Lipocalin family conserved site [IPR022272]", "Low-density lipoprotein (LDL) receptor class A, conserved site [IPR023415]", "Lysosome-associated membrane glycoprotein, conserved site [IPR018134]", "Macrophage migration inhibitory factor, conserved site [IPR019829]", "Malic enzyme, conserved site [IPR015884]", "Methylthiotransferase, conserved site [IPR020612]", "Mini-chromosome maintenance, conserved site [IPR018525]", "Mitogen-activated protein (MAP) kinase, conserved site [IPR003527]", "Molybdenum cofactor biosynthesis, conserved site [IPR008284]", "Myristoyl-CoA:protein N-myristoyltransferase, conserved site [IPR022678]", "NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site [IPR020396]", "NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site [IPR014029]", "NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site [IPR000283]", "NADH:ubiquinone oxidoreductase, subunit 1, conserved site [IPR018086]", "NUDIX hydrolase, conserved site [IPR020084]", "Oxysterol-binding protein, conserved site [IPR018494]", "P-type trefoil, conserved site [IPR017957]", "Peptidase M22, conserved site [IPR017860]", "Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site [IPR001131]", "Peptidase S26A, signal peptidase I, conserved site [IPR019758]", "Phosphatidylethanolamine-binding, conserved site [IPR001858]", "Phosphatidylinositol 3/4-kinase, conserved site [IPR018936]", "Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site [IPR018091]", "Phosphofructokinase, conserved site [IPR015912]", "Phosphoglucose isomerase, conserved site [IPR018189]", "Phosphoglycerate kinase, conserved site [IPR015911]", "Phosphomannose isomerase, type I, conserved site [IPR018050]", "Phosphoribosylglycinamide synthetase, conserved site [IPR020559]", "Phosphorylase pyridoxal-phosphate attachment site [IPR035090]", "Polyamine biosynthesis domain, conserved site [IPR030373]", "Polyprenyl synthetase, conserved site [IPR033749]", "Procollagen-lysine 5-dioxygenase, conserved site [IPR001006]", "Profilin conserved site [IPR027310]", "Proliferating cell nuclear antigen, PCNA, conserved site [IPR022659]", "Proteasome beta-type subunit, conserved site [IPR016050]", "Protein phosphatase 2A regulatory subunit PR55, conserved site [IPR018067]", "Proteinase inhibitor I2, Kunitz, conserved site [IPR020901]", "Proteinase inhibitor I25, cystatin, conserved site [IPR018073]", "Pseudouridine synthase TruD, conserved site [IPR020119]", "Purine phosphorylase, family 2, conserved site [IPR018099]", "Quinone oxidoreductase/zeta-crystallin, conserved site [IPR002364]", "RNA 3'-terminal phosphate cyclase-like, conserved site [IPR020719]", "RNA polymerase, beta subunit, conserved site [IPR007121]", "RNA polymerase, subunit H/Rpb5, conserved site [IPR020608]", "Ras GTPase-activating protein, conserved site [IPR023152]", "Retro-transposon transporting motif [IPR018892]", "Ribonuclease II/R, conserved site [IPR022966]", "Ribosomal RNA adenine methylase transferase, conserved site [IPR020596]", "Ribosomal S11, conserved site [IPR018102]", "Ribosomal S24e conserved site [IPR018098]", "Ribosomal protein L1, conserved site [IPR023673]", "Ribosomal protein L10e, conserved site [IPR018255]", "Ribosomal protein L11, conserved site [IPR020785]", "Ribosomal protein L13, conserved site [IPR023563]", "Ribosomal protein L13e, conserved site [IPR018256]", "Ribosomal protein L14P,  conserved site [IPR019972]", "Ribosomal protein L15, conserved site [IPR001196]", "Ribosomal protein L15e, conserved site [IPR020925]", "Ribosomal protein L18e, conserved site [IPR021132]", "Ribosomal protein L19/L19e conserved site [IPR023638]", "Ribosomal protein L2, conserved site [IPR022671]", "Ribosomal protein L21e, conserved site [IPR018259]", "Ribosomal protein L22/L17, conserved site [IPR018260]", "Ribosomal protein L23/L25, conserved site [IPR001014]", "Ribosomal protein L24/L26, conserved site [IPR005825]", "Ribosomal protein L24e, conserved site [IPR023442]", "Ribosomal protein L27e, conserved site [IPR018262]", "Ribosomal protein L29, conserved site [IPR018254]", "Ribosomal protein L3, conserved site [IPR019926]", "Ribosomal protein L30, conserved site [IPR018038]", "Ribosomal protein L30e, conserved site [IPR022991]", "Ribosomal protein L31e, conserved site [IPR020052]", "Ribosomal protein L32e, conserved site [IPR018263]", "Ribosomal protein L34e, conserved site [IPR018065]", "Ribosomal protein L35Ae, conserved site [IPR018266]", "Ribosomal protein L37e, conserved site [IPR018267]", "Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site [IPR013000]", "Ribosomal protein L5, conserved site [IPR020929]", "Ribosomal protein L6, conserved site-2 [IPR002359]", "Ribosomal protein L7Ae conserved site [IPR004037]", "Ribosomal protein S10, conserved site [IPR018268]", "Ribosomal protein S13, conserved site [IPR018269]", "Ribosomal protein S17, conserved site [IPR019979]", "Ribosomal protein S17e, conserved site [IPR018273]", "Ribosomal protein S19 conserved site [IPR020934]", "Ribosomal protein S19e, conserved site [IPR018277]", "Ribosomal protein S2, conserved site [IPR018130]", "Ribosomal protein S28e conserved site [IPR028626]", "Ribosomal protein S3, conserved site [IPR018280]", "Ribosomal protein S3Ae, conserved site [IPR018281]", "Ribosomal protein S4, conserved site [IPR018079]", "Ribosomal protein S4e, N-terminal, conserved site [IPR018199]", "Ribosomal protein S5, N-terminal, conserved site [IPR018192]", "Ribosomal protein S6e, conserved site [IPR018282]", "Ribosomal protein S7, conserved site [IPR020606]", "Ribosomal protein S8e, conserved site [IPR018283]", "Ribosomal protein S9, conserved site [IPR020574]", "Ribosome maturation protein SBDS, conserved site [IPR018023]", "RidA, conserved site [IPR019897]", "S-adenosyl-L-homocysteine hydrolase, conserved site [IPR020082]", "S-adenosylmethionine synthetase, conserved site [IPR022631]", "S100/Calbindin-D9k, conserved site [IPR001751]", "SAICAR synthetase, conserved site [IPR018236]", "SecY conserved site [IPR030659]", "Serpin, conserved site [IPR023795]", "Short-chain dehydrogenase/reductase, conserved site [IPR020904]", "Sodium:dicarboxylate symporter, conserved site [IPR018107]", "Squalene/phytoene synthase, conserved site [IPR019845]", "Stathmin, conserved site [IPR030514]", "Sterol reductase, conserved site [IPR018083]", "Succinyl-CoA synthetase, beta subunit, conserved site [IPR017866]", "Sugar transporter, conserved site [IPR005829]", "Sulfatase, conserved site [IPR024607]", "Syntaxin/epimorphin, conserved site [IPR006012]", "TPP-binding enzyme, conserved site [IPR000399]", "Terpene synthase, conserved site [IPR002365]", "Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site [IPR020867]", "Tetraspanin, conserved site [IPR018503]", "Thiolase, conserved site [IPR020613]", "Thioredoxin, conserved site [IPR017937]", "Thiosulphate sulfurtransferase, conserved site [IPR001307]", "Thymidine kinase, conserved site [IPR020633]", "Thymidylate kinase, conserved site [IPR018095]", "Tr-type G domain, conserved site [IPR031157]", "Translation elongation factor EF1B, beta/delta chains, conserved site [IPR001326]", "Translation elongation factor Ts, conserved site [IPR018101]", "Translationally controlled tumour protein, conserved site [IPR018103]", "Tubulin, conserved site [IPR017975]", "Tyrosine-protein kinase, receptor class II, conserved site [IPR002011]", "UbiE/COQ5 methyltransferase, conserved site [IPR023576]", "Ubiquitin conserved site [IPR019954]", "Ubiquitin interacting motif [IPR003903]", "Ubiquitin specific protease, conserved site [IPR018200]", "Ubiquitin-activating enzyme E1, conserved site [IPR018074]", "Vinculin, conserved site [IPR000633]", "WD40 repeat, conserved site [IPR019775]", "XPG conserved site [IPR019974]", "YgfZ/GcvT conserved site [IPR017703]", "Zinc finger, PHD-type, conserved site [IPR019786]", "Zinc finger, RING-type, conserved site [IPR017907]"], "available_proteins": ["AAAS", "AACS", "AAMP", "ABCB1", "ABCB7", "ABCC1", "ABCD3", "ABCE1", "ABCF1", "ABCF2", "ABCF3", "ACAA2", "ACAD9", "ACADM", "ACADSB", "ACADVL", "ACAT1", "ACAT2", "ACBD3", "ACBD5", "ACIN1", "ACLY", "ACSF3", "ACSL1", "ACSL3", "ACSL4", "ACTL6A", "ACTN1", "ACTN4", "ACTR1A", "ACTR2", "ACTR3", "ADH5", "ADK", "ADSL", "AFG3L2", "AHCY", "AHCYL1", "AK1", "AK2", "AK3", "AKR1A1", "AKR1B1", "ALDH18A1", "ALDH1B1", "ALDH2", "ALDH3A2", "ALDH4A1", "ALDH5A1", "ALDH6A1", "ALDH7A1", "ALDH9A1", "ALDOA", "ALDOC", "ANXA1", "ANXA11", "ANXA2", "ANXA3", "ANXA4", "ANXA6", "ANXA7", "AP1M1", "AP2M1", "AP2S1", "AP3M1", "AP3S1", "APEX1", "APLP2", "ARHGEF7", "ARIH2", "ATAD1", "ATAD2", "ATP5C1", "ATP5O", "BAG6", "BAZ1A", "BAZ1B", "BCS1L", "BDH2", "BOP1", "BPNT1", "BPTF", "BRD1", "BRD2", "BUD31", "CAD", "CALR", "CANX", "CAP1", "CAPZA1", "CAPZA2", "CAPZB", "CASK", "CBR1", "CBX1", "CBX3", "CBX5", "CBX8", "CCT2", "CCT3", "CCT4", "CCT5", "CCT6A", "CCT7", "CCT8", "CDH2", "CDKAL1", "CHAF1B", "CHD1", "CHD1L", "CHD4", "CMPK1", "CNDP2", "COLEC12", "COPA", "COPZ1", "CORO1C", "CPOX", "CRYZ", "CSTB", "CSTF1", "CTBP1", "CTBP2", "CTNNA1", "CUL1", "CUL2", "CUL3", "CUL4B", "CUL5", "CYP51A1", "DCAF13", "DCAF7", "DCPS", "DCXR", "DDX10", "DDX17", "DDX18", "DDX20", "DDX23", "DDX24", "DDX27", "DDX3X", "DDX42", "DDX46", "DDX47", "DDX49", "DDX5", "DDX51", "DDX54", "DDX55", "DDX6", "DHCR7", "DHFR", "DHRS7", "DHRS7B", "DHX15", "DHX16", "DHX29", "DHX30", "DHX33", "DHX35", "DHX36", "DHX38", "DHX40", "DHX57", "DHX8", "DHX9", "DIDO1", "DIMT1", "DIS3", "DNAJA1", "DNAJA2", "DNAJA3", "DNAJB1", "DNAJB11", "DNAJC1", "DNAJC10", "DNAJC11", "DNAJC2", "DNAJC9", "DNM1L", "DNM2", "DNMT1", "DRG1", "DRG2", "DSG2", "DTYMK", "DYNLL1", "DYNLL2", "EARS2", "ECH1", "ECHDC1", "ECHS1", "ECI1", "ECI2", "EEF1A2", "EEF1B2", "EEF1D", "EEF2", "EIF3I", "EIF4A1", "EIF4A2", "EIF4A3", "ENO1", "ENO2", "EPB41", "EPB41L2", "EPB41L3", "EPB41L5", "EPRS", "EPS15", "ERCC2", "ETFA", "ETFB", "EXO1", "EZR", "FARP2", "FBL", "FCGRT", "FDFT1", "FDPS", "FEN1", "FH", "FLNA", "FLNB", "FLNC", "FUCA1", "FUCA2", "GAA", "GALK1", "GALM", "GANAB", "GART", "GATB", "GCDH", "GEMIN5", "GFM1", "GLA", "GLB1", "GLB1L2", "GLO1", "GMPPA", "GNPDA1", "GNS", "GPHN", "GPI", "GPX8", "GRHPR", "GRWD1", "GSPT1", "GTF3C2", "GUSB", "H2AFX", "H4C1*", "HADH", "HADHA", "HADHB", "HGS", "HIBADH", "HINT2", "HLA-A", "HLA-B", "HLTF", "HMGA1", "HMGA2", "HMGB1", "HMGB2", "HMGB3", "HMGCR", "HMOX1", "HMOX2", "HSD17B10", "HSD17B12", "HSD17B4", "HSDL2", "HSP90AA1", "HSP90AB1", "HSP90B1", "HSPA13", "HSPA14", "HSPA1B", "HSPA2", "HSPA4", "HSPA4L", "HSPA8", "HSPA9", "HSPD1", "HSPE1", "HSPH1", "HYOU1", "IARS", "IARS2", "IBA57", "IDH1", "IDH2", "IDH3A", "IDH3B", "IGF1R", "ILVBL", "IMPAD1", "IMPDH2", "IQGAP1", "IQGAP2", "IVD", "KDM2A", "KDM5A", "KDSR", "KIF11", "KIF14", "KIF18A", "KIF1A", "KIF1B", "KIF20A", "KIF22", "KIF23", "KIF2A", "KIF2C", "KIF4A", "KIF5B", "LAMP1", "LARS", "LARS2", "LBR", "LIG3", "LMNA", "LMNB1", "LMNB2", "LRP1", "LRWD1", "LSS", "MACF1", "MAPK1", "MAPK14", "MARS", "MAT2A", "MCL1", "MCM2", "MCM3", "MCM4", "MCM5", "MCM6", "MCM7", "ME2", "MFSD14B", "MID1", "MIF", "MKRN2", "MPHOSPH8", "MPI", "MPP2", "MPP6", "MPP7", "MPST", "MRPL13", "MRPL24", "MRPL3", "MRPS11", "MRPS2", "MRPS5", "MRPS9", "MSN", "MTAP", "MTHFD1", "MTHFD1L", "MTHFD2", "MTOR", "ND1", "NDUFS1", "NDUFS2", "NDUFS3", "NEFM", "NF1", "NKTR", "NLE1", "NMT1", "NNT", "NOP2", "NSD2", "NSF", "NUDT1", "NUDT12", "NUDT5", "NUP153", "NUP37", "NUP43", "NVL", "OSBP", "OSBPL11", "OSBPL6", "OSBPL8", "OSBPL9", "OSGEP", "P4HB", "PAFAH1B1", "PAICS", "PAK1IP1", "PBRM1", "PCK2", "PCNA", "PDIA3", "PDIA4", "PDIA6", "PEBP1", "PEPD", "PFKL", "PFKM", "PFKP", "PFN1", "PFN2", "PGK1", "PGM1", "PGM2", "PGM3", "PHF3", "PHGDH", "PHIP", "PI4KA", "PIK3C2A", "PLEC", "PLOD1", "PLOD2", "PLRG1", "PLS1", "PLS3", "PNP", "POLA1", "POLD1", "POLR1B", "POLR1C", "POLR2B", "POLR2C", "POLR2E", "POLR3B", "PPIB", "PPIC", "PPID", "PPIF", "PPIH", "PPIL1", "PPP2R2A", "PRKAR1A", "PRKAR2A", "PRKDC", "PRPF19", "PRPF4", "PSMA4", "PSMB1", "PSMB2", "PSMB3", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PSMC1", "PSMC2", "PSMC3", "PSMC4", "PSMC5", "PSMC6", "PUS7", "PWP1", "PWP2", "PYGB", "PYGL", "QARS", "RACK1", "RAE1", "RANBP2", "RARS", "RCL1", "RDH13", "RDX", "RIDA", "RNF14", "RNF2", "RNF20", "RNF40", "RPL10", "RPL10A", "RPL11", "RPL12", "RPL13", "RPL13A", "RPL15", "RPL17", "RPL18", "RPL19", "RPL21", "RPL23", "RPL23A", "RPL24", "RPL26", "RPL27", "RPL27A", "RPL3", "RPL30", "RPL31", "RPL32", "RPL34", "RPL35", "RPL35A", "RPL37", "RPL4", "RPL7", "RPL7A", "RPL7L1", "RPL8", "RPL9", "RPS11", "RPS14", "RPS15", "RPS16", "RPS17", "RPS18", "RPS19", "RPS2", "RPS20", "RPS24", "RPS28", "RPS3", "RPS3A", "RPS4X", "RPS5", "RPS6", "RPS8", "RPS9", "RPSA", "RRP8", "RRP9", "RSF1", "RSL24D1", "RTN4IP1", "S100A11", "SART1", "SBDS", "SCAF11", "SCD", "SCP2", "SDHB", "SEC11A", "SEC61A1", "SERPINB6", "SERPINH1", "SLC1A5", "SLC27A4", "SLC2A1", "SLIT2", "SMARCA4", "SMU1", "SNRNP40", "SNU13", "SORD", "SPTBN1", "SRCAP", "SRM", "STAM", "STMN1", "STX12", "STX18", "STX4", "STX5", "STX7", "SUCLA2", "SUCLG1", "SUCLG2", "SV2A", "SYNE2", "TAF5", "TBL3", "TCP1", "TFB1M", "THOC6", "TK1", "TLN1", "TMX1", "TMX4", "TOP2A", "TOP2B", "TPT1", "TRIM21", "TRIM24", "TRIM25", "TRIM28", "TRIM33", "TRIP13", "TRMT11", "TSFM", "TSPAN6", "TST", "TUBB", "TUBB2B", "TUBB4B", "TUBB6", "TUFM", "TXNDC12", "TXNDC5", "TXNL1", "UBA1", "UBA2", "UBFD1", "UHRF1", "USP10", "USP11", "USP14", "USP19", "USP24", "USP28", "USP33", "USP36", "USP47", "USP48", "USP5", "USP7", "USP8", "USP9X", "UTP15", "UTP18", "UTRN", "VARS1", "VAT1", "VCL", "VCP", "VIM", "VPS4A", "VPS4B", "WARS", "WARS2", "WDHD1", "WDR1", "WDR11", "WDR12", "WDR18", "WDR3", "WDR36", "WDR5", "WDR61", "WDR77", "XPNPEP1", "YARS2", "YME1L1", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAQ", "YWHAZ", "ZADH2", "ZMYND8"], "leading_proteins": ["ANXA1", "ANXA11", "CASK", "DNAJA2", "DNAJC2", "FCGRT", "FH", "FUCA2", "GLB1L2", "HLA-A", "HMGA1", "HMGA2", "HMOX2", "HSP90B1", "IDH2", "MFSD14B", "MID1", "MKRN2", "MPP2", "MTHFD2", "MTOR", "NSD2", "PFN2", "PI4KA", "POLR2C", "PSMB1", "PSMB2", "PSMB4", "PSMB5", "PSMB6", "PSMB7", "PYGL", "RNF14", "RNF2", "RNF20", "STAM", "SUCLG1", "TRIM21", "TRIM25", "TUBB", "TUBB2B", "TXNDC12", "USP24", "USP28", "USP33", "USP47", "VIM", "YWHAB", "YWHAE", "YWHAG", "YWHAH", "YWHAZ"]}

interpro_domain/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "K Homology domain [IPR004087]", "1": "K Homology domain, type 1 [IPR004088]"}

interpro_domain/basic/idx2term.json

@@ -0,0 +1 @@
+{"0": "K Homology domain [IPR004087]", "1": "K Homology domain, type 1 [IPR004088]", "2": "Immunoglobulin-like domain [IPR007110]", "3": "RNA recognition motif domain [IPR000504]", "4": "RNA recognition motif domain, eukaryote [IPR003954]", "5": "DnaJ domain [IPR001623]", "6": "Zinc finger, RING-type [IPR001841]", "7": "14-3-3 domain [IPR023410]", "8": "EF-hand domain [IPR002048]"}

interpro_domain/consensus.joblib

@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:6898378697f02201c3da93b38822823fb9c1ffc60e4cdbd833aa0df0b71b4508
+size 310515

interpro_domain/df_merge.tsv

@@ -0,0 +1,9 @@
+term	overlap	setsize	score	pval	overlap_mean	setsize_mean	score_mean	pval_mean	overlap_std	setsize_std	score_std	pval_std	pval_hit	pval_50	pval_100	pval_250	pval_500
+K Homology domain [IPR004087]	10	24	2.4711187978496074	0.0134691066127679	8.029126213592233	22.796116504854368	0.328818420881894	0.600646587147133	4.351556602822176	1.3994397166034702	0.8923876485619237	0.3352669927506027	0.203636451009126	1.0	0.2732850813359189	0.0010720436073174	2.2380734395490096e-06
+K Homology domain, type 1 [IPR004088]	14	25	2.454455132119253	0.0141098271336326	8.5	23.218446601941743	0.4539576731478794	0.576935027430011	4.690674491420825	1.6401661988255969	0.9187340965418598	0.3398774289684012	0.2091215881148182	1.0	0.2802926639431586	0.0012324742743759	3.03436196363312e-06
+Importin-alpha, importin-beta-binding domain [IPR002652]	3	5	2.148923203572935	0.0316404881232532	1.900485436893204	4.179611650485437	-0.0879924391494337	0.5961199277101574	1.2177090368111774	0.6874547431954602	0.834731806091852	0.3002594480637005	1.6933873035860414e-05	6.108202829893653e-06	4.656667989155393e-05	2.1451255431067108e-05	0.0003286021100258
+Glutathione S-transferase, C-terminal-like [IPR010987]	2	11	2.103588473516944	0.0354143602828445	3.949029126213592	11.37621359223301	-0.0908035435769439	0.5323098181486043	2.6346872162188446	1.2313530457632356	0.9588413776865506	0.2992576122582335	1.0	1.0	0.1432798584585485	0.0061570039439817	0.0397387250697101
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	4	5	2.079564438003141	0.0375655016550349	2.813106796116505	6.104368932038835	1.6405397264547834	0.1100883340733615	1.2852875686886795	0.8042848477475721	1.100790504333474	0.1612592696854457	0.0029333243921292	0.0573151884822011	0.0001778916397324	0.0001405335592956	0.0001575214550341
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	4	6	2.0492681978473724	0.0404358966063769	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.053639682462237	0.0385773062479974	0.0743799864466655	0.1775366954381628	1.3106068439724131e-05
+Aminopeptidase N-like , N-terminal domain [IPR045357]	4	6	2.0492681978473724	0.0404358966063769	2.121359223300971	5.466019417475728	1.4317001483019938	0.1783942022754649	1.021530403905949	0.5881604361499402	0.986353205880356	0.2226891741813114	0.053639682462237	0.0385773062479974	0.0743799864466655	0.1775366954381628	1.3106068439724131e-05
+Major facilitator superfamily domain [IPR020846]	3	6	1.9746318978282709	0.0483099364679044	1.8883495145631068	4.121359223300971	0.8776223597987594	0.2728824130413255	1.233496960525634	1.4580976091979958	1.2936014196902064	0.266909732326598	0.0011017003564739	0.0093923264669034	0.0028960612595367	0.0348798008289802	0.0553856285019619

interpro_domain/metrics.json

@@ -0,0 +1,7 @@
+{
+    "type_of_task": "ranksum",
+    "signature_size": 2812,
+    "annotations_size": 2406,
+    "title": "Average number of proteins per term",
+    "value": 2.117206982543641
+}

interpro_domain/paths.json

@@ -0,0 +1 @@
+{"results_path": "results/proteins/hek293t_core/interpro_domain/fragment/C428/C428_val_log2fc"}

interpro_domain/result.tsv

@@ -0,0 +1,201 @@
+Term	es	nes	pval	sidak	fdr	geneset_size	leading_edge	leading_edge_size
+K Homology domain [IPR004087]	0.5922644896176035	2.4711187978496074	0.0134691066127679	0.9999999999999932	0.1139359320270197	24	O75179,Q06787,Q96PU8,P51116,Q92945,P61978,O75525,Q96I24,P51114,Q07666	10
+K Homology domain, type 1 [IPR004088]	0.5752663539568165	2.454455132119253	0.0141098271336326	0.9999999999999986	0.1158276850884974	25	O75179,Q06787,Q8N9N2,Q96PU8,P51116,O00425,Q92945,P61978,O75525,Q96I24,P51114,Q9Y6M1,Q07666,Q96AE4	14
+Importin-alpha, importin-beta-binding domain [IPR002652]	0.9176634815703018	2.148923203572935	0.0316404881232532	1.0	0.161628480731523	5	O00505,O00629,P52294	3
+Glutathione S-transferase, C-terminal-like [IPR010987]	0.6985700746218859	2.1035884735169437	0.0354143602828445	1.0	0.1710982948604897	11	P78417,Q9H7Z7	2
+Cytochrome b5-like heme/steroid binding domain [IPR001199]	0.899893124332025	2.079564438003141	0.0375655016550349	1.0	0.1752393602139337	5	Q8WUJ1,O15173,Q9UMX5,O43169	4
+Peptidase M1, membrane alanine aminopeptidase [IPR014782]	0.8212779723845033	2.0492681978473724	0.0404358966063769	1.0	0.1814445122781584	6	Q9UIQ6,P55786,P09960,Q6P179	4
+Aminopeptidase N-like , N-terminal domain [IPR045357]	0.8212779723845033	2.0492681978473724	0.0404358966063769	1.0	0.1814445122781584	6	Q9UIQ6,P55786,P09960,Q6P179	4
+Major facilitator superfamily domain [IPR020846]	0.803558260149732	1.9746318978282709	0.0483099364679044	1.0	0.2020789250013052	6	P53985,Q8NHS3,Q5SR56	3
+Glutathione S-transferase, N-terminal [IPR004045]	0.7601347537465126	1.959556471329725	0.05004765330281	1.0	0.2069585805808564	7	P78417,Q9H7Z7	2
+Immunoglobulin-like domain [IPR007110]	0.6897991519066345	1.9304894193940836	0.0535462249515932	1.0	0.2125944178771176	10	P10321,P55899,P01889,P35613,Q9Y624,P04439	6
+Zinc finger, RanBP2-type [IPR001876]	0.6842331572472559	1.788583716006373	0.073681882292935	1.0	0.2525336307646748	9	Q01844,P35637,P98175,Q92804	4
+RNA recognition motif domain [IPR000504]	0.3780943250263766	1.7810638075719618	0.0749020274444776	1.0	0.2548999689270341	112	P52597,O14979,P38159,Q13310,P35637,P23588,P43243,Q9Y6M1,P22626,P31943,P11940,P55795,Q13242,P31483,Q9UHX1,Q92804,O60506,Q4G0J3,P52756,O43390,Q99729,Q9BWF3,P51991,Q14011,Q14103,Q01844,P98175,P31942,P62995,P98179,Q01085,Q96PK6	32
+Fragile X-related 1 protein, C-terminal region 1 [IPR032172]	0.951957295373668	1.758434834126742	0.0786735504549116	1.0	0.2629251317231654	2	P51114	1
+RNA recognition motif domain, eukaryote [IPR003954]	0.5994223252477137	1.7302570267759745	0.0835843636834723	1.0	0.2681386386965792	13	P11940,P38159,Q13310,P31483,Q9UHX1,Q14011	6
+Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain [IPR044862]	0.9441281138790056	1.7264113510662955	0.0842734351160052	1.0	0.2690723829502813	2	Q32P28	1
+Glycoside hydrolase 35, catalytic domain [IPR031330]	0.9434163701067636	1.7234980663625985	0.0847984945480808	1.0	0.2695180685372292	2	Q8IW92	1
+Phospholipase D/Transphosphatidylase [IPR001736]	0.9423487544484016	1.7191275190771442	0.0855911549313568	1.0	0.2700208909992507	2	Q8IV08	1
+Heterogeneous nuclear ribonucleoprotein Q acidic domain [IPR041337]	0.9245551601423484	1.6461843605536597	0.0997258081500418	1.0	0.2874931042767934	2	O60506	1
+Guanylate kinase/L-type calcium channel beta subunit [IPR008145]	0.7913048432684406	1.645369200447852	0.0998936970803821	1.0	0.2874931042767934	5	Q9NZW5,Q14168,O14936	3
+Guanylate kinase-like domain [IPR008144]	0.7913048432684406	1.645369200447852	0.0998936970803821	1.0	0.2874931042767934	5	Q9NZW5,Q14168,O14936	3
+MHC class I-like antigen recognition-like [IPR011161]	0.8871082621082568	1.6122517880371663	0.1069071599367319	1.0	0.2980517112488726	4	P55899,P01889,P04439	3
+Immunoglobulin C1-set [IPR003597]	0.8871082621082568	1.6122517880371663	0.1069071599367319	1.0	0.2980517112488726	4	P55899,P01889,P04439	3
+RBM3/CIRBP, RNA recognition motif [IPR034278]	0.91245551601424	1.5964906931212774	0.1103792820129438	1.0	0.3028193301290114	2	Q14011	1
+Reticulon [IPR003388]	0.9078291814946656	1.577474598436556	0.1146863624278788	1.0	0.311439489843653	2	O95197	1
+B30.2/SPRY domain [IPR001870]	0.6407641220522117	1.5746961365899472	0.1153266000185226	1.0	0.3124727473474837	9	O15344,Q14258,P19474,Q1KMD3	4
+SPRY domain [IPR003877]	0.6407641220522117	1.5746961365899472	0.1153266000185226	1.0	0.3124727473474837	9	O15344,Q14258,P19474,Q1KMD3	4
+Glutathione S-transferase, C-terminal [IPR004046]	0.6322869943079006	1.5325415440562258	0.1253888539969834	1.0	0.3332338347852791	9	P78417	1
+L27 domain [IPR004172]	0.8615887284167849	1.515047308890242	0.1297604238773468	1.0	0.3367891907755087	4	Q14168,O14936	2
+L27 domain, C-terminal [IPR014775]	0.8615887284167849	1.515047308890242	0.1297604238773468	1.0	0.3367891907755087	4	Q14168,O14936	2
+TRAM/LAG1/CLN8 homology domain [IPR006634]	0.8900355871886219	1.5042795358596175	0.132509405974633	1.0	0.3395288932640756	2	Q96G23	1
+Ion transporter-like, CBS domain [IPR044751]	0.8896797153024895	1.5028150005660998	0.1328867566133942	1.0	0.3397720897043852	2	Q8NE01	1
+CNNM, transmembrane domain [IPR002550]	0.8896797153024895	1.5028150005660998	0.1328867566133942	1.0	0.3397720897043852	2	Q8NE01	1
+B-box-type zinc finger [IPR000315]	0.6901625814889605	1.4840857559442124	0.1377861715630246	1.0	0.3456831124662298	6	P19474	1
+SET domain [IPR001214]	0.6881835004112326	1.4753535512316205	0.1401175161626704	1.0	0.3464776401720298	6	Q9BYW2,Q03164,O96028	3
+ERAP1-like C-terminal domain [IPR024571]	0.8486467236467139	1.4655954367685229	0.1427585351731908	1.0	0.3504867710476501	4	Q9UIQ6,P55786,Q6P179	3
+AWS domain [IPR006560]	0.8779359430605049	1.4544799644304398	0.1458132843046899	1.0	0.3568939593459655	2	O96028	1
+Zinc finger, CHHC-type [IPR012996]	0.9394802420790316	1.4522151174934543	0.1464418005062295	1.0	0.3577045401197851	3	P31943,P52597	2
+CARG-binding factor, N-terminal [IPR012956]	0.8750889679715312	1.4427621503463457	0.1490874847589189	1.0	0.3630612230060314	2	Q99729	1
+Damage-control phosphatase ARMT1-like, metal-binding domain [IPR002791]	0.8725978647686944	1.432509497834365	0.1519980619010712	1.0	0.3690285942825201	2	Q9NVE7	1
+Isopropylmalate dehydrogenase-like domain [IPR024084]	0.8390366092740751	1.4288214842023483	0.1530555489331098	1.0	0.3710466953478706	4	P48735	1
+KHDRBS, Qua1 domain [IPR032571]	0.866903914590747	1.409077592325294	0.1588122258421545	1.0	0.3760519656856069	2	Q07666	1
+Sam68, tyrosine-rich domain [IPR032335]	0.866903914590747	1.409077592325294	0.1588122258421545	1.0	0.3760519656856069	2	Q07666	1
+Survival motor neuron [IPR010304]	0.861565836298931	1.3871155581813812	0.1654065286001942	1.0	0.3827651423267089	2	O75940	1
+Alpha-L-fucosidase, C-terminal [IPR031919]	0.8594306049822151	1.378332726868318	0.1681005832940041	1.0	0.3851904794336894	2	Q9BTY2	1
+Post-SET domain [IPR003616]	0.8241829898770809	1.37191478163803	0.1700899682340306	1.0	0.387901861204813	4	Q03164,O96028	2
+MD-2-related lipid-recognition domain [IPR003172]	0.8523131672597872	1.349067305287513	0.1773153486260035	1.0	0.3972260044638402	2	P17900	1
+PABP, RNA recognition motif 2 [IPR045305]	0.8508896797153012	1.3432165420477604	0.1792018667873742	1.0	0.4010787827817883	2	Q13310	1
+Tubulin/FtsZ, 2-layer sandwich domain [IPR018316]	0.8063443746058448	1.3035067198458916	0.1924018237166755	1.0	0.4189310297396574	4	Q9BVA1,P07437	2
+Tubulin/FtsZ, GTPase domain [IPR003008]	0.8063443746058448	1.3035067198458916	0.1924018237166755	1.0	0.4189310297396574	4	Q9BVA1,P07437	2
+Acyl-CoA oxidase, C-terminal [IPR002655]	0.8373665480427062	1.2876854558604762	0.1978554784113486	1.0	0.4254158007664922	2	O15254	1
+Zinc finger C2H2 AKAP95-type [IPR034736]	0.8935564257743009	1.2837262281210593	0.199237763939132	1.0	0.4273189070310756	3	Q9ULX6,O43823	2
+GMP phosphodiesterase, delta subunit [IPR008015]	0.8934073378491953	1.2831797396824145	0.1994291123728846	1.0	0.4273189070310756	3	A6NIH7	1
+OCRE domain [IPR041591]	0.8355871886121061	1.280386972243283	0.200409073463436	1.0	0.4278942738384472	2	P98175	1
+MHC class I alpha chain, alpha1 alpha2 domains [IPR001039]	0.8867924528301944	1.258940457750245	0.208051839158192	1.0	0.4375635708169668	3	P01889,P04439	2
+MHC class I, alpha chain, C-terminal [IPR010579]	0.8867924528301944	1.258940457750245	0.208051839158192	1.0	0.4375635708169668	3	P01889,P04439	2
+Tudor domain [IPR002999]	0.6025885176168068	1.233586325627956	0.2173570910639881	1.0	0.4485898009756484	7	Q12888,O75940,Q14739,Q16637	4
+Phospholipid/glycerol acyltransferase [IPR002123]	0.6897004185932325	1.2268456654060458	0.2198806036074834	1.0	0.4529389831161002	5	Q8NF37	1
+SPRY-associated [IPR006574]	0.7852540319851418	1.2226265063731925	0.221470796945431	1.0	0.4531111713016217	4	O15344,P19474	2
+Butyrophylin-like, SPRY domain [IPR003879]	0.7852540319851418	1.2226265063731925	0.221470796945431	1.0	0.4531111713016217	4	O15344,P19474	2
+Fxr1, tudor domain [IPR041560]	0.8743325026699966	1.2133347167636144	0.2250018748299735	1.0	0.4556856151859565	3	P51116,P51114	2
+Fragile X-related 1 protein, C-terminal core [IPR022034]	0.8743325026699966	1.2133347167636144	0.2250018748299735	1.0	0.4556856151859565	3	P51116,P51114	2
+Synaptic functional regulator FMRP, KH0 domain [IPR040472]	0.8743325026699966	1.2133347167636144	0.2250018748299735	1.0	0.4556856151859565	3	P51116,P51114	2
+Agenet-like domain [IPR008395]	0.8743325026699966	1.2133347167636144	0.2250018748299735	1.0	0.4556856151859565	3	P51116,P51114	2
+PB1 domain [IPR000270]	0.8174377224199298	1.2060901481343207	0.227782733098252	1.0	0.4593841205652929	2	Q13501	1
+Prolyl 4-hydroxylase, alpha subunit [IPR006620]	0.7741515238894369	1.1800895116065315	0.2379646156759509	1.0	0.4696824161741904	4	Q32P28	1
+Oxoglutarate/iron-dependent dioxygenase [IPR005123]	0.7741515238894369	1.1800895116065315	0.2379646156759509	1.0	0.4696824161741904	4	Q32P28	1
+Ataxin-2, C-terminal [IPR009818]	0.770323205893024	1.1654338820811494	0.2438434090798664	1.0	0.4724231477310595	4	Q9BPZ3	1
+ZU5 domain [IPR000906]	0.8049822064056941	1.1553004468402517	0.2479674130458953	1.0	0.4780525607279039	2	Q12955	1
+Zinc finger, PHD-finger [IPR019787]	0.4678858706242527	1.1189003965867304	0.2631826337746838	1.0	0.5001717352779538	17	Q03164,O96028	2
+Cold-shock (CSD) domain [IPR019844]	0.8477368398284326	1.1163305771064922	0.2642806577551226	1.0	0.5005631886600457	3	P16989	1
+Glycoside hydrolase family 2, catalytic domain [IPR006103]	0.7946619217081998	1.113375847217036	0.2655470437013365	1.0	0.5007101780136487	2	P08236	1
+CBS domain [IPR000644]	0.6555509830194992	1.08536223757018	0.2777612505856135	1.0	0.5113187214299817	5	Q8NE01,Q6P4Q7	2
+DnaJ domain [IPR001623]	0.4616724177955711	1.0786304095823454	0.2807525194662277	1.0	0.512511807159138	17	O75937,O60884,O14976,Q9UBS4,Q8WXX5,Q99543	6
+Proteasome alpha-subunit, N-terminal domain [IPR000426]	0.5695943914393442	1.0780240648467938	0.2810230168778727	1.0	0.5126166630842772	7	P60900	1
+Alpha/beta hydrolase fold-1 [IPR000073]	0.743157328548635	1.0617144457035907	0.2883653393355225	1.0	0.5208854051265497	4	P07099	1
+Polyketide synthase, enoylreductase domain [IPR020843]	0.563871220293723	1.051054518261157	0.2932335513245063	1.0	0.5257227455191968	7	Q8N4Q0	1
+EB1, C-terminal [IPR004953]	0.7765124555160293	1.040082592236118	0.2983015304518219	1.0	0.5308531673573104	2	Q15555	1
+FF domain [IPR002713]	0.7736654804270442	1.0286445210539383	0.3036467489014369	1.0	0.5383744125695337	2	O75400	1
+Polyadenylate-binding protein/Hyperplastic disc protein [IPR002004]	0.8108697896180743	0.9831251007023052	0.3255458719224726	1.0	0.5615949825837417	3	Q13310	1
+Cold-shock protein, DNA-binding [IPR002059]	0.7221873829800936	0.982157237560385	0.3260223908800443	1.0	0.5615949825837417	4	P16989	1
+Cold shock domain [IPR011129]	0.7221873829800936	0.982157237560385	0.3260223908800443	1.0	0.5615949825837417	4	P16989	1
+Alanyl-tRNA synthetase, class IIc, N-terminal [IPR018164]	0.7601423487544646	0.9745691334738243	0.329774030785475	1.0	0.56198882804678	2	Q5JTZ9	1
+SKP1 component, POZ domain [IPR016073]	0.7569395017793746	0.961829074965588	0.3361354704491568	1.0	0.5695365788032897	2	Q15369	1
+VHS domain [IPR002014]	0.8006709146435746	0.9466479735147622	0.3438181895697125	1.0	0.5760630669252983	3	Q92783	1
+Zinc finger, C3HC4 RING-type [IPR018957]	0.7998908725510874	0.94386622426822	0.3452380137918398	1.0	0.5776374556211172	3	Q9H000	1
+Far upstream element-binding protein, C-terminal [IPR015096]	0.7505338078291997	0.9364339786563928	0.3490497901731682	1.0	0.5779876801362074	2	Q92945	1
+Immunoglobulin subtype 2 [IPR003598]	0.6179987906740531	0.9307472370638687	0.3519843286470241	1.0	0.5783183715775281	5	P35613,Q9Y624	2
+Immunoglobulin subtype [IPR003599]	0.6179987906740531	0.9307472370638687	0.3519843286470241	1.0	0.5783183715775281	5	P35613,Q9Y624	2
+Tyrosine-specific protein phosphatases domain [IPR000387]	0.7065593968419235	0.923290535634937	0.3558558187111824	1.0	0.5816502036814571	4	Q06124	1
+Protein-tyrosine phosphatase, catalytic [IPR003595]	0.6032661347955754	0.8706700530733326	0.3839343344032975	1.0	0.6105393315098042	5	Q9Y217,Q06124	2
+Elp3/MiaB/NifB [IPR006638]	0.7220640569394998	0.8251615653007712	0.4092798708375746	1.0	0.6300239086597599	2	Q9H9T3	1
+Radical SAM [IPR007197]	0.7220640569394998	0.8251615653007712	0.4092798708375746	1.0	0.6300239086597599	2	Q9H9T3	1
+Tyrosine-specific protein phosphatase, PTPase domain [IPR000242]	0.7637273682891424	0.8164311930840994	0.4142535620767806	1.0	0.6340293068427062	3	Q06124	1
+La-type HTH domain [IPR006630]	0.5845653087203403	0.7951365864499644	0.4265340543995344	1.0	0.6425876218834892	5	Q71RC2,Q92615,Q4G0J3	3
+Alcohol dehydrogenase-like, C-terminal [IPR013149]	0.5081410131614378	0.7905984786532552	0.4291783349029456	1.0	0.6445712071014277	7	Q8N4Q0	1
+GRAM domain [IPR004182]	0.7530800880209885	0.7795890591824987	0.4356327978338581	1.0	0.6502062726974334	3	Q66K14	1
+Zinc finger, PHD-type [IPR001965]	0.3989836817066715	0.737378161595933	0.4608924121306219	1.0	0.6710831276476932	19	Q03164,O96028	2
+Thioredoxin domain [IPR013766]	0.3676610467179695	0.7153815918890511	0.4743732839745016	1.0	0.6842578664524286	23	O95881	1
+Ubiquitin specific protease domain [IPR028889]	0.4115589155064142	0.7129301417991798	0.4758889863511513	1.0	0.6855969729308878	15	Q96K76,Q9UPU5,Q8TEY7,Q96RU2	4
+Peptidase C19, ubiquitin carboxyl-terminal hydrolase [IPR001394]	0.4115589155064142	0.7129301417991798	0.4758889863511513	1.0	0.6855969729308878	15	Q96K76,Q9UPU5,Q8TEY7,Q96RU2	4
+Chaperone DnaJ, C-terminal [IPR002939]	0.5627270498865	0.7082912137046636	0.4787644322608637	1.0	0.6855969729308878	5	O60884	1
+Vicinal oxygen chelate (VOC) domain [IPR037523]	0.6911032028469907	0.707902138901403	0.4790060313785629	1.0	0.6855969729308878	2	Q9HC38	1
+Zinc finger, RING-type [IPR001841]	0.3565241458942679	0.6337514544719741	0.5262430391978095	1.0	0.7140056427440178	23	O15344,Q5VTR2,Q9H000,O96028,P19474,Q14258,Q9UBS8	7
+Ancestral coatomer element 1, Sec16/Sec31 [IPR024298]	0.6683274021352416	0.6248802602571827	0.5320496488578921	1.0	0.7165399491473509	2	O15027	1
+MIT domain [IPR007330]	0.7026295551325513	0.6107504931106372	0.5413647727215791	1.0	0.7208210532197673	3	Q8N0X7	1
+Peptidase M3A/M3B catalytic domain [IPR001567]	0.7009611961552226	0.6053604860685285	0.5449394998182422	1.0	0.7239736852849488	3	P52888,Q9BYT8	2
+EF-hand, Ca insensitive [IPR014837]	0.6996349664793747	0.6010859517247729	0.5477827397079256	1.0	0.7243355869109165	3	O43707	1
+Proteasome activator PA28, N-terminal domain [IPR003185]	0.6986471175756438	0.5979079432511784	0.549901359461868	1.0	0.7253633063954247	3	Q9UL46	1
+Proteasome activator PA28, C-terminal domain [IPR003186]	0.6986471175756438	0.5979079432511784	0.549901359461868	1.0	0.7253633063954247	3	Q9UL46	1
+Peptidase S9A, N-terminal domain [IPR023302]	0.6576512455515993	0.5870980581418421	0.5571378516763432	1.0	0.7256211900403913	2	P48147	1
+CSN8/PSMD8/EIF3K [IPR033464]	0.6882436429582525	0.5647547473288169	0.5722405906902777	1.0	0.7288569937537365	3	Q99627	1
+DNA mismatch repair protein MutS, clamp [IPR007861]	0.6501779359430602	0.5611302099253878	0.5747087751001785	1.0	0.7289735787562879	2	P52701	1
+Myosin tail [IPR002928]	0.6391459074733076	0.5235731805723369	0.6005754392996314	1.0	0.7437788449452045	2	P35580	1
+Heterogeneous nuclear ribonucleoprotein U, SPRY domain [IPR035778]	0.673905304378795	0.5200689913014827	0.6030154900524882	1.0	0.7438577989584768	3	Q1KMD3,Q00839	2
+Exoribonuclease, phosphorolytic domain 1 [IPR001247]	0.4571802115115873	0.4718075414562852	0.6370641674939277	1.0	0.7596780484221531	6	Q96B26	1
+Peptidase S9, prolyl oligopeptidase, catalytic domain [IPR001375]	0.6578853684585282	0.4716597073818241	0.6371697014613071	1.0	0.7596780484221531	3	P13798,P48147	2
+Peptidase M28 [IPR007484]	0.6479174083303755	0.4424203942743796	0.6581850237673159	1.0	0.7691262174052669	3	P02786,Q7Z2K6	2
+High mobility group box domain [IPR009071]	0.3775121293366457	0.3911559626279307	0.6956819569976009	1.0	0.796294380845018	11	O96028	1
+14-3-3 domain [IPR023410]	0.4354953670705573	0.3889432256894514	0.6973181452731891	1.0	0.7977876640643333	6	P31946,P61981,P62258,P63104,Q04917	5
+Chromo domain subgroup [IPR017984]	0.6197935208259199	0.3639868607495716	0.7158678209969831	1.0	0.8105308128558782	3	P83916,P45973	2
+Chromo shadow domain [IPR008251]	0.6197935208259199	0.3639868607495716	0.7158678209969831	1.0	0.8105308128558782	3	P83916,P45973	2
+Pentacotripeptide-repeat region of PRORP [IPR033443]	0.5879003558718799	0.3633429448592051	0.7163487168208023	1.0	0.8106937971170509	2	O75127	1
+Arf GTPase activating protein [IPR001164]	0.6088286344223349	0.3351822953559556	0.7374875766063946	1.0	0.8310984118571361	3	Q8N6H7	1
+4Fe-4S ferredoxin-type, iron-sulphur binding domain [IPR017896]	0.6032495276519393	0.3209368281338575	0.7482582641751945	1.0	0.8410152624842163	3	P21912	1
+Plectin/S10, N-terminal [IPR005326]	0.5725978647686762	0.3207699453849517	0.7483847368988807	1.0	0.8410152624842163	2	P46783	1
+Glutaredoxin, PICOT-like [IPR033658]	0.5701067615658293	0.3140959095354865	0.7534481961618609	1.0	0.8459152403011839	2	Q86SX6	1
+Fibronectin type III [IPR003961]	0.414277736602073	0.3125984658607055	0.7545857438226329	1.0	0.8460080613407525	6	O15344,P15260	2
+PIK-related kinase, FAT [IPR003151]	0.5989768142844951	0.310220186689701	0.7563935205070074	1.0	0.8468510052768077	3	P42345	1
+FATC domain [IPR003152]	0.5989768142844951	0.310220186689701	0.7563935205070074	1.0	0.8468510052768077	3	P42345	1
+PIK-related kinase [IPR014009]	0.5989768142844951	0.310220186689701	0.7563935205070074	1.0	0.8468510052768077	3	P42345	1
+EF-hand domain [IPR002048]	0.2982011830811519	0.3080509542546885	0.7580435603880629	1.0	0.8481788437319886	40	Q14257,O43852,Q8NF37,P60660,Q66K14,Q96D71,P80303,Q9H223	8
+26S proteasome regulatory subunit Rpn7, N-terminal [IPR045135]	0.566192170818498	0.3037575445393421	0.7613126138079509	1.0	0.8499852198709651	2	Q15008	1
+B-box, C-terminal [IPR003649]	0.5195624081296228	0.2958585463240671	0.7673381097647218	1.0	0.8550286140873139	4	O15344,O15164	2
+PTB/PI domain [IPR006020]	0.5753781512308855	0.2541857975247754	0.7993520222896837	1.0	0.8779101816858662	3	Q9UKG1	1
+Nucleoporin, Nup133/Nup155-like, C-terminal [IPR007187]	0.5437722419928737	0.2481860535306156	0.8039904565166489	1.0	0.8818256047198483	2	O75694	1
+AP complex, mu/sigma subunit [IPR022775]	0.3924744427094533	0.2399799345818553	0.8103458120207869	1.0	0.8874337841247216	6	Q92572	1
+Cation-transporting P-type ATPase, C-terminal [IPR006068]	0.568529725881099	0.238966283178691	0.8111317275073899	1.0	0.8874865558812097	3	P05023,P16615	2
+Cation-transporting P-type ATPase, N-terminal [IPR004014]	0.568529725881099	0.238966283178691	0.8111317275073899	1.0	0.8874865558812097	3	P05023,P16615	2
+GTP binding domain [IPR006073]	0.3407844011837203	0.2273571777596639	0.820146015570105	1.0	0.8965339906686383	11	Q9NTK5	1
+Alanyl-tRNA synthetase, class IIc, core domain [IPR018165]	0.5582458022377343	0.2170291606658201	0.8281856195738049	1.0	0.9028611693224172	3	Q5JTZ9	1
+UAS [IPR006577]	0.5291814946619157	0.2154843161184799	0.8293897387828204	1.0	0.9037643620975842	2	Q9UNN5	1
+NUC153 [IPR012580]	0.5252669039145853	0.20718995217928	0.835861514063698	1.0	0.9079380599716738	2	Q9BSC4	1
+EH domain [IPR000261]	0.415508728358317	0.2051320836305624	0.8374689302840732	1.0	0.9092735768337004	5	Q96D71	1
+Sorting nexin Vps5-like, C-terminal [IPR015404]	0.4779183656719624	0.1932821848522684	0.8467379776884598	1.0	0.917680889332628	4	Q9Y5X3	1
+Cyclin, N-terminal [IPR006671]	0.498932384341627	0.156761866877834	0.8754325270320047	1.0	0.9419904561891784	2	P14635	1
+Cyclin, C-terminal domain [IPR004367]	0.498932384341627	0.156761866877834	0.8754325270320047	1.0	0.9419904561891784	2	P14635	1
+Cyclin-like [IPR013763]	0.498932384341627	0.156761866877834	0.8754325270320047	1.0	0.9419904561891784	2	P14635	1
+Acyltransferase, C-terminal domain [IPR032098]	0.4914590747330924	0.1441632332268464	0.8853715732458827	1.0	0.9480213641431214	2	Q6UWP7	1
+EF hand associated, type-2 [IPR013567]	0.4900355871886024	0.1418490469391789	0.8871992418738401	1.0	0.9487117226437596	2	Q8IXI2	1
+EF hand associated, type-1 [IPR013566]	0.4900355871886024	0.1418490469391789	0.8871992418738401	1.0	0.9487117226437596	2	Q8IXI2	1
+MIRO domain [IPR020860]	0.4900355871886024	0.1418490469391789	0.8871992418738401	1.0	0.9487117226437596	2	Q8IXI2	1
+PurM-like, N-terminal domain [IPR016188]	0.4825622775800588	0.1301462325110684	0.8964507328921139	1.0	0.9572618609742553	2	P49903	1
+Diaphanous autoregulatory (DAD) domain [IPR014767]	0.4807829181494624	0.1274699188195953	0.8985684802423217	1.0	0.9572618609742553	2	Q9NSV4	1
+Formin, FH2 domain [IPR015425]	0.4807829181494624	0.1274699188195953	0.8985684802423217	1.0	0.9572618609742553	2	Q9NSV4	1
+Rho GTPase-binding/formin homology 3 (GBD/FH3) domain [IPR014768]	0.4807829181494624	0.1274699188195953	0.8985684802423217	1.0	0.9572618609742553	2	Q9NSV4	1
+Formin, GTPase-binding domain [IPR010473]	0.4807829181494624	0.1274699188195953	0.8985684802423217	1.0	0.9572618609742553	2	Q9NSV4	1
+Formin, FH3 domain [IPR010472]	0.4807829181494624	0.1274699188195953	0.8985684802423217	1.0	0.9572618609742553	2	Q9NSV4	1
+Fumarate lyase, N-terminal [IPR022761]	0.4765124555160116	0.1212182236464325	0.9035181901715184	1.0	0.9614616388998996	2	P07954	1
+Methylglyoxal synthase-like domain [IPR011607]	0.4736654804270333	0.1171841295606635	0.906714143041124	1.0	0.9633303715338728	2	P27708	1
+PDZ domain [IPR001478]	0.2918527568596658	0.1032875428155255	0.9177347621319298	1.0	0.9722896687315822	14	Q14168,O14936	2
+DNA-directed RNA polymerase, RpoA/D/Rpb3-type [IPR011263]	0.4608540925266834	0.1003337346565336	0.920079376227837	1.0	0.9739159609345251	2	P19387	1
+DNA-directed RNA polymerase, insert domain [IPR011262]	0.4608540925266834	0.1003337346565336	0.920079376227837	1.0	0.9739159609345251	2	P19387	1
+Myosin, N-terminal, SH3-like [IPR004009]	0.4855820576717659	0.0949891125708488	0.9243234747263886	1.0	0.9773963328348846	3	P35580,P35579	2
+PurM-like, C-terminal domain [IPR010918]	0.4827340690637214	0.0913947840774877	0.9271789061085948	1.0	0.9786924417320502	3	O15067,P49903	2
+E3 ligase, CCCH-type zinc finger [IPR041367]	0.4824709724599879	0.0910671664384913	0.9274392215914692	1.0	0.9786924417320502	3	Q86VM9	1
+Dynamin, GTPase domain [IPR001401]	0.481310074759695	0.0896304854393414	0.9285808580219956	1.0	0.9789826204654472	3	O00429,P50570	2
+Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [IPR000866]	0.4166666666666684	0.0805848225225785	0.9357721368177392	1.0	0.9836032158949238	4	Q13162,P32119,P30048	3
+Peroxiredoxin, C-terminal [IPR019479]	0.4166666666666684	0.0805848225225785	0.9357721368177392	1.0	0.9836032158949238	4	Q13162,P32119,P30048	3
+PITH domain [IPR010400]	0.4395017793594304	0.0768058271823557	0.9387780150137636	1.0	0.985302885383403	2	Q9GZP4	1
+Tyrosine-protein kinase, catalytic domain [IPR020635]	0.4373665480427027	0.0747513888053096	0.9404125196579728	1.0	0.985302885383403	2	P41240	1
+PTBP1, RNA recognition motif 2-like [IPR021790]	0.4355871886120964	0.0730791295806138	0.9417431494261104	1.0	0.985302885383403	2	P14866	1
+Threonine-tRNA ligase catalytic core domain [IPR033728]	0.4352313167259776	0.0727489833087745	0.9420058687406784	1.0	0.985302885383403	2	Q9BW92	1
+UBX domain [IPR001012]	0.3555397221232547	0.0725841805126126	0.9421370156335338	1.0	0.985302885383403	5	Q9UNZ2,Q9BZE9,Q96CS3,Q9UNN5	4
+CoA-binding [IPR003781]	0.4330960854092507	0.0707980076245964	0.9435585175327748	1.0	0.985302885383403	2	P53597	1
+Sec24-like, trunk domain [IPR041742]	0.4327402135231324	0.0704778020019084	0.9438133680449864	1.0	0.985302885383403	2	O95486	1
+Suppressor of forked [IPR008847]	0.4295373665480415	0.0676589877683259	0.9460570974811102	1.0	0.985302885383403	2	Q12996	1
+RNA polymerase Rpb2, domain 4 [IPR007646]	0.4259786476868291	0.0646581695283873	0.9484461689725524	1.0	0.985302885383403	2	P30876	1
+RNA polymerase Rpb2, domain 5 [IPR007647]	0.4259786476868291	0.0646581695283873	0.9484461689725524	1.0	0.985302885383403	2	P30876	1
+Cyclic nucleotide-binding domain [IPR000595]	0.3988927325394414	0.0567823016644491	0.9547186124146368	1.0	0.9909633224631648	4	Q6P4Q7	1
+Exosome complex component, N-terminal domain [IPR025721]	0.4060498220640572	0.0502608086149217	0.9599145544700176	1.0	0.994640145587796	2	Q13868	1
+ATP-citrate lyase/succinyl-CoA ligase [IPR005811]	0.3888888888888864	0.0450907990835288	0.9640349352324512	1.0	0.9984795756217294	4	P53597,P53396,Q96I99	3
+FCP1 homology domain [IPR004274]	0.393594306049824	0.0431580144626221	0.9655755734879669	1.0	0.9992978915454458	2	Q3ZCQ8	1
+Ricin B, lectin domain [IPR000772]	0.3787641324882675	0.0344624500790233	0.9725083850462262	1.0	1.0	4	Q86SF2	1
+Exportin-2, central domain [IPR013713]	0.4211463154147384	0.033826508090197	0.973015497638507	1.0	1.0	3	O95373,P55060	2
+Translation initiation factor, beta propellor-like domain [IPR013979]	0.3717948717948708	0.0278260703343727	0.97780087289041	1.0	1.0	4	Q9BY44,Q9NV06,P55884	3
+Intermediate filament, rod domain [IPR039008]	0.3250450491084149	0.0263915572335404	0.978945028157653	1.0	1.0	5	P08670	1
+Pseudouridine synthase II, N-terminal [IPR002501]	0.3277580071174438	0.0232540991378444	0.9814475853836372	1.0	1.0	2	Q8WWH5	1
+PUA domain [IPR002478]	0.3277580071174382	0.0232540991378435	0.981447585383638	1.0	1.0	2	Q9Y221	1
+Ribosomal protein S7 domain [IPR023798]	0.3227758007117504	0.0225894229249594	0.9819777809595094	1.0	1.0	2	Q9Y2R9	1
+PPM-type phosphatase domain [IPR001932]	0.3645467173177931	0.0214899558567693	0.982854815679406	1.0	1.0	4	O15355,Q15750	2
+N-acetylgalactosaminyltransferase [IPR045885]	0.3963151656411804	0.0201190999195162	0.9839483636962982	1.0	1.0	3	Q86SF2	1
+Ran binding domain [IPR000156]	0.3596866096866112	0.0175537005267803	0.9859948926063156	1.0	1.0	4	Q9H6Z4,P49792,Q9UKX7	3
+Zinc finger, CCCH-type [IPR000571]	0.2699665572160721	0.0167435481325521	0.9866412056365536	1.0	1.0	13	Q9H000,Q86VM9,Q8IWR0	3
+PWWP domain [IPR000313]	0.2905213678852493	0.0153021684337256	0.9877911125265572	1.0	1.0	9	O96028,Q7Z4V5,P52701	3
+Glutamine amidotransferase type 2 domain [IPR017932]	0.3670345318618778	0.0092866671912947	0.992590418129996	1.0	1.0	3	Q06203,P08243	2
+DNA mismatch repair protein MutS-like, N-terminal [IPR007695]	0.3616945532217912	0.0078224083248476	0.9937586848204608	1.0	1.0	3	P43246,P52701	2
+DNA mismatch repair protein MutS, C-terminal [IPR000432]	0.3616945532217912	0.0078224083248476	0.9937586848204608	1.0	1.0	3	P43246,P52701	2
+DNA mismatch repair protein MutS, core [IPR007696]	0.3616945532217912	0.0078224083248476	0.9937586848204608	1.0	1.0	3	P43246,P52701	2
+DNA mismatch repair protein MutS, connector domain [IPR007860]	0.3616945532217912	0.0078224083248476	0.9937586848204608	1.0	1.0	3	P43246,P52701	2
+Dbl homology (DH) domain [IPR000219]	0.3189747241011074	0.0002623447159112	0.9997906792039672	1.0	1.0	3	O94887,Q14155	2

interpro_family/advanced/idx2term.json

@@ -0,0 +1 @@
+{"0": "Proteasome, subunit alpha/beta [IPR001353]", "1": "Proteasome B-type subunit [IPR023333]"}