| term overlap setsize score pval | |
| Metabolism of rna 380 568 8.34274352089459 7.258648547158942e-17 | |
| Regulation of expression of slits and robos 110 136 6.7307594949128005 1.6877974873761193e-11 | |
| Eukaryotic translation initiation 93 106 6.570030710182439 5.030488574549042e-11 | |
| Influenza infection 107 137 6.514815517537175 7.277904906005434e-11 | |
| Rrna processing 133 187 6.427195364850753 1.2997972835867952e-10 | |
| Eukaryotic translation elongation 69 81 6.344806471643134 2.2270522544900943e-10 | |
| Translation 183 261 6.331458795283256 2.428540293394917e-10 | |
| Srp dependent cotranslational protein targeting to membrane 78 98 6.274866056746988 3.4993541019842166e-10 | |
| Selenoamino acid metabolism 71 97 6.21557073042207 5.113843141919415e-10 | |
| Metabolism of amino acids and derivatives 160 229 6.206924609618644 5.403150190666102e-10 | |
| Response of eif2ak4 gcn2 to amino acid deficiency 68 83 6.013604006718923 1.814434249882329e-09 | |
| Nonsense mediated decay nmd 73 96 5.998863277754008 1.987035682013449e-09 | |
| Signaling by robo receptors 111 162 5.9281240783754345 3.06414937374348e-09 | |
| Processing of capped intron containing pre mrna 161 220 5.63038240572381 1.7981050240399505e-08 | |
| Auf1 hnrnp d0 binds and destabilizes mrna 36 43 5.6097628145568645 2.0260409874723148e-08 | |
| Host interactions of hiv factors 80 106 5.6070344603902775 2.05822692893408e-08 | |
| Degradation of axin 32 38 5.500340739271608 3.7905800058635344e-08 | |
| Cross presentation of soluble exogenous antigens endosomes 32 39 5.495952844509319 3.886063493350509e-08 | |
| Scf skp2 mediated degradation of p27 p21 35 43 5.475371117316507 4.3659563133354344e-08 | |
| Stabilization of p53 33 42 5.466013482301559 4.602693451841812e-08 | |
| G1 s dna damage checkpoints 33 45 5.283664267471123 1.2662521713254742e-07 | |
| Negative regulation of notch4 signaling 35 43 5.28292675222222 1.2713623311042046e-07 | |
| Mrna splicing 125 170 5.253006940748148 1.4963589517200594e-07 | |
| Metabolism of polyamines 33 42 5.240677961581973 1.599877104046918e-07 | |
| Asymmetric localization of pcp proteins 33 41 5.23869143315147 1.617191692204568e-07 | |
| Degradation of dvl 33 41 5.222135177141432 1.7687177598356045e-07 | |
| Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 45 54 5.2218221350366685 1.7717109994554934e-07 | |
| Regulation of runx3 expression and activity 32 41 5.207564346847383 1.913354967873651e-07 | |
| Cellular response to starvation 74 106 5.206155957308376 1.927926314134197e-07 | |
| Cytosolic trna aminoacylation 21 23 5.131615541441036 2.872657983299728e-07 | |
| Rrna modification in the nucleus and cytosol 47 60 5.129573832309437 2.903988576630216e-07 | |
| Regulation of mrna stability by proteins that bind au rich elements 44 71 4.992104555153194 5.972490708661127e-07 | |
| Defective cftr causes cystic fibrosis 34 46 4.987418248806876 6.119149897898524e-07 | |
| Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 38 55 4.936082831301075 7.970726541017825e-07 | |
| Hedgehog ligand biogenesis 34 46 4.871954312122943 1.1049972539201036e-06 | |
| Tnfr2 non canonical nf kb pathway 35 47 4.860382316363649 1.1715927357158762e-06 | |
| Dectin 1 mediated noncanonical nf kb signaling 35 47 4.826695043501563 1.388174374339357e-06 | |
| The role of gtse1 in g2 m progression after g2 checkpoint 41 55 4.825382846670698 1.3973458441451925e-06 | |
| Regulation of hmox1 expression and activity 40 52 4.782641682448687 1.7300636181438731e-06 | |
| Regulation of ras by gaps 33 44 4.759060963607555 1.944956895982841e-06 | |
| Disorders of transmembrane transporters 63 91 4.739253427898774 2.1450708462822377e-06 | |
| Apc c mediated degradation of cell cycle proteins 43 65 4.72460066993092 2.3056797655574e-06 | |
| Orc1 removal from chromatin 40 59 4.6879881136597055 2.7590403932631347e-06 | |
| Pcp ce pathway 38 56 4.645107932593078 3.398987049818558e-06 | |
| Regulation of runx2 expression and activity 34 48 4.618878946845184 3.858188490024617e-06 | |
| Glucose metabolism 53 68 4.557255906164385 5.1826265319299125e-06 | |
| Degradation of gli1 by the proteasome 34 47 4.5056216932962005 6.617889885207617e-06 | |
| Trna aminoacylation 27 41 4.476076905415015 7.602710836440707e-06 | |
| Cellular responses to stimuli 232 447 4.457500909542242 8.292068545578957e-06 | |
| Fceri mediated nf kb activation 34 55 4.429937584814176 9.426036529314176e-06 | |
| Antigen processing cross presentation 41 63 4.423799145670462 9.698018869963576e-06 | |
| Cdt1 association with the cdc6 orc origin complex 32 47 4.414380975703066 1.0129943022407772e-05 | |
| Signaling by notch4 36 51 4.411132236893562 1.0283149074030716e-05 | |
| Cellular response to hypoxia 34 48 4.384147638094604 1.1644078735884024e-05 | |
| Abc family proteins mediated transport 39 63 4.373192750828742 1.2244252620252638e-05 | |
| The retinoid cycle in cones daylight vision 1 1 -4.35665445295537 1.3206551106037525e-05 | |
| Regulation of pten stability and activity 36 50 4.342591280797941 1.4081194976256484e-05 | |
| Recycling of bile acids and salts 1 1 -4.339698161588158 1.4267855561467258e-05 | |
| Infectious disease 217 480 4.335169253630654 1.4564801378069704e-05 | |
| Cyclin a cdk2 associated events at s phase entry 35 53 4.304775768791202 1.6715495512631406e-05 | |
| Interactions of rev with host cellular proteins 28 37 4.300357808316916 1.7052255718130738e-05 | |
| Histidine catabolism 1 1 -4.29374584460607 1.7568357764563558e-05 | |
| Glycolysis 43 56 4.292397871330312 1.7675385683313394e-05 | |
| Switching of origins to a post replicative state 43 70 4.286897599217434 1.8118576254000374e-05 | |
| Tnfr1 mediated ceramide production 0 1 4.2856681420597456 1.821907875498852e-05 | |
| Degradation of beta catenin by the destruction complex 37 58 4.241618560869664 2.2191360999901377e-05 | |
| Nuclear envelope breakdown 35 47 4.219451063989823 2.4489787087356163e-05 | |
| Adenylate cyclase activating pathway 1 1 -4.20022119684327 2.666543409990396e-05 | |
| Gene and protein expression by jak stat signaling after interleukin 12 stimulation 20 26 4.188151773921201 2.8123542110014554e-05 | |
| Interactions of vpr with host cellular proteins 30 37 4.173412141198905 3.000714085787948e-05 | |
| Runx1 regulates transcription of genes involved in differentiation of hscs 33 49 4.167997876848897 3.0728679627278765e-05 | |
| Flt3 signaling through src family kinases 1 1 -4.156969647326634 3.2249681781948425e-05 | |
| Nervous system development 144 290 4.15015649211882 3.322480406753314e-05 | |
| Diseases associated with surfactant metabolism 1 1 -4.146556013865944 3.375136383532151e-05 | |
| Synthesis of dna 54 101 4.140754979341216 3.461645743496611e-05 | |
| Transport of fatty acids 0 1 4.08578576117633 4.392789799823049e-05 | |
| Uch proteinases 38 58 4.076950637235705 4.563017504954914e-05 | |
| Abc transporter disorders 34 52 4.054566491321949 5.022736258553096e-05 | |
| Cgmp effects 1 1 -4.043458937188616 5.266838387507633e-05 | |
| Nitric oxide stimulates guanylate cyclase 1 1 -4.043458937188616 5.266838387507633e-05 | |
| Dna replication pre initiation 43 76 4.040518109400926 5.333324635570236e-05 | |
| Hdl remodeling 1 1 -4.016161548939355 5.915371413989234e-05 | |
| Mitotic prophase 54 72 4.013858638423233 5.973412909354714e-05 | |
| Nuclear import of rev protein 25 34 4.006942938646804 6.150971578455788e-05 | |
| Synthesis of bile acids and bile salts via 27 hydroxycholesterol 1 1 -4.005570745409294 6.186791303264272e-05 | |
| Downstream signaling events of b cell receptor bcr 34 57 4.004957720977576 6.202857429116193e-05 | |
| Rhobtb gtpase cycle 24 31 3.962613837065861 7.413363928909789e-05 | |
| Phosphate bond hydrolysis by ntpdase proteins 1 1 -3.961296624187705 7.454385932614827e-05 | |
| Programmed cell death 64 136 3.958803281754294 7.532624620365524e-05 | |
| Sodium calcium exchangers 0 1 3.9345043887376 8.336854554436002e-05 | |
| Ns1 mediated effects on host pathways 29 38 3.927977029122145 8.566339064275397e-05 | |
| Hedgehog on state 34 52 3.908461538750978 9.28857307800346e-05 | |
| Transport of mature transcript to cytoplasm 56 76 3.881984295725577 0.0001036075697733 | |
| Tcr signaling 36 63 3.873249568937585 0.0001073937538573 | |
| Activated ntrk2 signals through pi3k 0 1 3.873047492188788 0.0001074828727856 | |
| Transcriptional regulation by runx3 35 54 3.8634839286902896 0.0001117812507942 | |
| Apoptosis 58 120 3.862886395606865 0.0001120551263937 | |
| Mapk6 mapk4 signaling 39 60 3.8573427111134273 0.0001146263937041 | |
| Antiviral mechanism by ifn stimulated genes 44 59 3.8545559263060265 0.0001159398793111 | |
| Nuclear pore complex npc disassembly 26 34 3.851574904645599 0.0001173606203388 | |
| Irs activation 1 1 -3.818009132909217 0.0001345329464621 | |
| Interleukin 1 signaling 35 61 3.8034392036668097 0.0001427010270156 | |
| Fibronectin matrix formation 0 1 3.784080670564552 0.0001542777809282 | |
| Export of viral ribonucleoproteins from nucleus 23 32 3.78018069902773 0.0001567145800782 | |
| Androgen biosynthesis 0 1 3.7578407186081058 0.0001713859146956 | |
| Dna replication 62 111 3.742785895620183 0.0001819912876499 | |
| Interleukin 12 family signaling 26 33 3.695679110773992 0.0002192998129126 | |
| Sumoylation of dna replication proteins 26 41 3.673347500138991 0.0002393935717368 | |
| Slc transporter disorders 26 39 3.667934109666669 0.0002445181734058 | |
| Negative regulation of activity of tfap2 ap 2 family transcription factors 1 1 -3.6639091323877766 0.0002483949379405 | |
| Irak4 deficiency tlr2 4 0 1 3.648382710654559 0.0002638963302747 | |
| Initiation of nuclear envelope ne reformation 14 19 3.648118089032717 0.0002641682207813 | |
| Rhobtb2 gtpase cycle 17 21 3.64107790098189 0.0002714989639782 | |
| Biosynthesis of epa derived spms 0 1 3.618030054418399 0.0002968539310792 | |
| Cellular response to chemical stress 55 100 3.611948825359654 0.0003039045472987 | |
| Dopamine clearance from the synaptic cleft 0 1 3.603274021679474 0.0003142339473392 | |
| Hiv infection 93 180 3.5729189521231874 0.0003530240488203 | |
| Transcriptional regulation by runx2 36 67 3.563067853311186 0.0003665458853701 | |
| Acyl chain remodeling of dag and tag 1 1 -3.562962054763152 0.000366693700585 | |
| S phase 59 123 3.5620177009592333 0.0003680155646423 | |
| Ampk inhibits chrebp transcriptional activation activity 1 2 -3.556742453580671 0.000375481940817 | |
| Termination of o glycan biosynthesis 1 1 -3.5517721479031543 0.0003826460574396 | |
| Cytoprotection by hmox1 51 86 3.548668928759088 0.0003871835549609 | |
| Regulation of glucokinase by glucokinase regulatory protein 21 30 3.545702939008301 0.000391567350608 | |
| Citric acid cycle tca cycle 17 21 3.543227591458277 0.00039526142744 | |
| Mitotic g1 phase and g1 s transition 50 100 3.519026507291357 0.0004331334292091 | |
| G2 m checkpoints 55 115 3.5092268342846555 0.0004494114409994 | |
| Gluconeogenesis 16 22 3.5088370713939243 0.0004500705243168 | |
| Folding of actin by cct tric 7 8 3.4980000605550843 0.0004687610261941 | |
| Clec7a dectin 1 signaling 34 65 3.479937721410538 0.0005015303523325 | |
| Nr1h2 nr1h3 regulate gene expression linked to gluconeogenesis 1 1 -3.4758367545600364 0.0005092621751425 | |
| Nr1h2 nr1h3 regulate gene expression linked to triglyceride lipolysis in adipose 1 1 -3.4758367545600364 0.0005092621751425 | |
| Nr1h2 nr1h3 regulate gene expression to limit cholesterol uptake 1 1 -3.4758367545600364 0.0005092621751425 | |
| Cytokine signaling in immune system 124 243 3.4741282181649678 0.0005125160635943 | |
| Ptk6 promotes hif1a stabilization 1 1 -3.4730107245315947 0.0005146547897902 | |
| Erbb2 activates ptk6 signaling 1 1 -3.4730107245315947 0.0005146547897902 | |
| Tfap2 ap 2 family regulates transcription of cell cycle factors 2 2 -3.472776200465592 0.000515104690836 | |
| Interleukin 12 signaling 21 30 3.470937116059664 0.0005186454423569 | |
| Activation of ras in b cells 1 1 -3.465469855796633 0.0005293058597897 | |
| Apoptotic execution phase 23 39 3.446900667453833 0.0005670570331142 | |
| Snrnp assembly 35 48 3.435888700664739 0.0005906135521236 | |
| Transport of mature mrnas derived from intronless transcripts 33 43 3.4356135019102454 0.0005912137531995 | |
| Defensins 1 1 -3.43523647760679 0.0005920369548677 | |
| Alpha defensins 1 1 -3.43523647760679 0.0005920369548677 | |
| Purine ribonucleoside monophosphate biosynthesis 8 10 3.402138632257333 0.0006686071235895 | |
| Regulation of signaling by nodal 1 1 -3.374431275192746 0.0007396838285651 | |
| Reelin signalling pathway 2 2 -3.3609527889692767 0.0007767410111036 | |
| Oxidative stress induced senescence 23 41 -3.3602489505583137 0.0007787226783952 | |
| Signaling by the b cell receptor bcr 34 65 3.354397363219167 0.0007953805380349 | |
| Butyrophilin btn family interactions 1 1 -3.3390701420953213 0.0008405933624335 | |
| Viral messenger rna synthesis 30 41 3.329977885501562 0.0008685288185263 | |
| Beta catenin independent wnt signaling 38 73 3.328850175765125 0.0008720530217016 | |
| Sumoylation of sumoylation proteins 21 32 3.321766433292796 0.0008944953685987 | |
| Transport of the slbp dependant mature mrna 28 36 3.32057494849716 0.0008983223540215 | |
| G alpha 12 13 signalling events 11 24 -3.3051754437511867 0.000949169642892 | |
| Ub specific processing proteases 53 102 3.2860812325968234 0.0010159170771508 | |
| Mitotic metaphase and anaphase 91 188 3.2806406467601086 0.0010357161122547 | |
| Pyruvate metabolism and citric acid tca cycle 28 41 3.275866887314512 0.0010533819629898 | |
| Signaling by membrane tethered fusions of pdgfra or pdgfrb 1 1 -3.2717476915005523 0.0010688491631976 | |
| Chylomicron remodeling 2 2 -3.267438153347437 0.001085255755556 | |
| Rhobtb1 gtpase cycle 16 21 3.261612215096206 0.001107805760927 | |
| Postmitotic nuclear pore complex npc reformation 19 25 3.258638289995727 0.0011194830027743 | |
| Sodium proton exchangers 1 1 -3.249505378929946 0.0011560589187284 | |
| Intrinsic pathway of fibrin clot formation 1 2 3.237520930672827 0.0012057309457262 | |
| Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation 2 3 3.2314869548121403 0.0012314794501002 | |
| Cs ds degradation 1 2 3.221168365159216 0.0012766912301271 | |
| Tcf dependent signaling in response to wnt 41 83 3.220464854886214 0.0012798288405617 | |
| Sumoylation of rna binding proteins 24 41 3.2020432047851424 0.0013645653014564 | |
| Signaling by interleukins 70 154 3.178726734453214 0.0014792347573422 | |
| Neutrophil degranulation 115 242 3.1579780724109257 0.0015886750727502 | |
| Metabolism of carbohydrates 72 135 3.133872177404524 0.0017251598783365 | |
| Neurotransmitter clearance 1 2 3.133708041036556 0.0017261250841011 | |
| Regulation of hsf1 mediated heat shock response 41 67 3.1243029996982266 0.0017822682189878 | |
| Erythropoietin activates stat5 1 2 -3.074772721194165 0.0021066302147043 | |
| Abacavir metabolism 0 1 3.0697733128230893 0.0021422129853059 | |
| Blood group systems biosynthesis 2 2 -3.0682710282044985 0.0021530125216804 | |
| Rmts methylate histone arginines 17 23 3.064254813358436 0.0021821296121151 | |
| Abacavir transmembrane transport 0 1 3.0530380317571986 0.0022653722567409 | |
| Interleukin 1 family signaling 34 69 3.0380327461106096 0.0023812807666858 | |
| Aspartate and asparagine metabolism 4 5 3.030296391113725 0.002443138536968 | |
| Chemokine receptors bind chemokines 2 2 -3.030154435315646 0.0024442871915799 | |
| Activated ntrk3 signals through pi3k 1 1 -3.0186958495164826 0.0025386525534485 | |
| Signaling by notch1 13 26 -3.0181699028344986 0.0025430628417835 | |
| Notch1 intracellular domain regulates transcription 10 19 -3.012526882937691 0.0025908248761132 | |
| Ncam1 interactions 1 1 -3.011719426600543 0.0025977257972371 | |
| Il 6 type cytokine receptor ligand interactions 2 2 -3.010583519447056 0.0026074622742493 | |
| Fertilization 1 1 -3.009725067552216 0.0026148426540761 | |
| Defective b4galt1 causes b4galt1 cdg cdg 2d 1 1 -3.009725067552216 0.0026148426540761 | |
| Interaction with cumulus cells and the zona pellucida 1 1 -3.009725067552216 0.0026148426540761 | |
| Vldl clearance 3 3 -2.9889970283001355 0.0027989485395409 | |
| Transcriptional regulation of white adipocyte differentiation 15 33 -2.964527632001228 0.0030314801680189 | |
| Golgi to er retrograde transport 65 93 2.9471593050987948 0.0032070793669847 | |
| Signaling by notch1 pest domain mutants in cancer 11 21 -2.935999566947152 0.0033247478661924 | |
| Terminal pathway of complement 1 1 -2.918463065766788 0.0035176154398288 | |
| Inositol phosphate metabolism 9 18 -2.917495483486102 0.0035285475886666 | |
| Signaling by gpcr 36 94 -2.9099755286453632 0.0036145705632739 | |
| Association of tric cct with target proteins during biosynthesis 12 22 2.909839844053622 0.0036161400682934 | |
| Beta oxidation of octanoyl coa to hexanoyl coa 4 5 2.9002892600973817 0.003728184384562 | |
| Dna strand elongation 21 34 2.900159343232388 0.0037297300474907 | |
| Signaling by alk in cancer 29 41 2.8875189854230614 0.003882931717942 | |
| Digestion 0 1 2.885865103543042 0.0039033942285593 | |
| Digestion and absorption 0 1 2.885865103543042 0.0039033942285593 | |
| Creatine metabolism 1 3 2.8760197008052124 0.0040272457531178 | |
| Sumoylation of ubiquitinylation proteins 21 35 2.866079917346972 0.0041558931719392 | |
| Metabolism of nucleotides 36 62 2.859716182623358 0.0042402030362374 | |
| Nuclear envelope ne reassembly 44 62 2.851578652071101 0.0043502722454946 | |
| Trna processing in the nucleus 34 53 2.846055688282244 0.0044264453141196 | |
| Norepinephrine neurotransmitter release cycle 2 3 -2.8368711068824912 0.0045557999584697 | |
| Serotonin neurotransmitter release cycle 2 3 -2.8368711068824912 0.0045557999584697 | |
| Acetylcholine neurotransmitter release cycle 2 3 -2.8368711068824912 0.0045557999584697 | |
| Passive transport by aquaporins 0 1 2.836487204095518 0.0045612806086319 | |
| Defects of contact activation system cas and kallikrein kinin system kks 0 1 2.8344657826352258 0.004590237337563 | |
| Gamma carboxylation transport and amino terminal cleavage of proteins 0 1 2.8344657826352258 0.004590237337563 | |
| Defective factor ix causes hemophilia b 0 1 2.8344657826352258 0.004590237337563 | |
| M phase 141 277 2.8183727099060274 0.0048267745106822 | |
| Acyl chain remodeling of cl 1 3 2.8129410263053387 0.0049090653493033 | |
| Metabolism of angiotensinogen to angiotensins 2 3 -2.8062925224315363 0.0050115174379989 | |
| Cellular response to heat stress 47 79 2.8039323674914693 0.0050483493585526 | |
| Activation of the phototransduction cascade 1 1 -2.7975666055570025 0.0051489149907486 | |
| Sensory perception of taste 1 1 -2.7975666055570025 0.0051489149907486 | |
| Activation of the tfap2 ap 2 family of transcription factors 2 3 -2.789880430811208 0.0052727510212997 | |
| Pou5f1 oct4 sox2 nanog activate genes related to proliferation 0 1 2.78174308434231 0.0054067822932033 | |
| Release of hh np from the secreting cell 1 1 -2.7729674761055185 0.0055547672128808 | |
| Signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant 1 1 -2.7729674761055185 0.0055547672128808 | |
| Runx3 regulates yap1 mediated transcription 3 3 -2.7727629795212585 0.0055582588445211 | |
| Yap1 and wwtr1 taz stimulated gene expression 3 3 -2.7727629795212585 0.0055582588445211 | |
| Developmental biology 161 388 2.772245513511669 0.0055671030514865 | |
| Mitochondrial calcium ion transport 13 19 2.767786172801406 0.0056438471508304 | |
| Hydrolysis of lpc 0 1 2.767493843957189 0.0056489112304658 | |
| Transcriptional regulation by small rnas 24 47 2.7669400642701203 0.005658515721717 | |
| Regulation of lipid metabolism by pparalpha 18 48 -2.764359301678221 0.0057034698060418 | |
| Pre notch expression and processing 12 27 -2.7460847663685035 0.0060311178478968 | |
| Mrna decay by 3 to 5 exoribonuclease 12 16 2.74602466687601 0.0060322227997831 | |
| Interleukin 2 signaling 3 3 -2.740041597336768 0.0061431408910854 | |
| Defective ext2 causes exostoses 2 1 1 -2.739023663770474 0.0061621937915856 | |
| Runx1 regulates transcription of genes involved in differentiation of keratinocytes 1 2 -2.7359137038340737 0.0062207337159829 | |
| Josephin domain dubs 1 3 2.728819377804211 0.0063561507750415 | |
| Ticam1 dependent activation of irf3 irf7 1 1 -2.725613553529977 0.0064182094990967 | |
| Condensation of prometaphase chromosomes 8 11 2.7219396521286616 0.0064899992840321 | |
| Beta oxidation of lauroyl coa to decanoyl coa coa 3 4 2.7087132519292525 0.0067544688958331 | |
| O glycosylation of tsr domain containing proteins 2 2 -2.706617630587745 0.0067972496831125 | |
| Foxo mediated transcription of cell death genes 4 4 -2.7040535434518698 0.0068499250466376 | |
| Cellular hexose transport 2 3 -2.6987000172409794 0.0069610892747584 | |
| Nucleotide biosynthesis 10 15 2.698228587054765 0.0069709555749994 | |
| Zinc influx into cells by the slc39 gene family 2 3 -2.694304372021294 0.0070535719433353 | |
| Estrogen biosynthesis 0 1 2.6876787857436963 0.0071950573199655 | |
| Apoptotic cleavage of cellular proteins 11 27 2.686353908832828 0.0072236529958522 | |
| Common pathway of fibrin clot formation 1 1 -2.6842152366410805 0.007270028605042 | |
| Protein repair 0 1 2.683566166027465 0.0072841559972478 | |
| Separation of sister chromatids 67 146 2.6762708223995197 0.0074446461124142 | |
| Retinoid cycle disease events 2 2 -2.664914740342992 0.0077007843881209 | |
| Hedgehog off state 37 71 2.6647352622522167 0.0077048951798932 | |
| Loss of function of smad2 3 in cancer 2 2 -2.6556188106889063 0.007916304187399 | |
| Runx3 regulates bcl2l11 bim transcription 2 2 -2.6556188106889063 0.007916304187399 | |
| Foxo mediated transcription of cell cycle genes 2 2 -2.6556188106889063 0.007916304187399 | |
| Regulation of foxo transcriptional activity by acetylation 4 5 -2.6369967728257686 0.0083643627335203 | |
| Unfolded protein response upr 31 53 2.6286897718406563 0.0085714515538559 | |
| Cholesterol biosynthesis 9 23 2.628681236241274 0.0085716666781057 | |
| Hdl clearance 1 2 2.6245705616597568 0.0086758313905734 | |
| Interconversion of nucleotide di and triphosphates 13 23 2.6216744764986726 0.008749896161043 | |
| Ca2 pathway 9 18 -2.6210493862908235 0.0087659562223703 | |
| Cross presentation of particulate exogenous antigens phagosomes 1 1 -2.6175469765055834 0.008856429694489 | |
| Abacavir transport and metabolism 1 2 2.616261326645718 0.0088898490412916 | |
| Vitamin c ascorbate metabolism 1 3 2.615471039382035 0.0089104477287873 | |
| Dectin 2 family 2 3 -2.6042473333106195 0.0092076283473889 | |
| Protein methylation 5 7 2.5997082860746272 0.009330303735894 | |
| Resolution of abasic sites ap sites 24 32 2.598507903055639 0.0093629889731734 | |
| Acyl chain remodelling of pi 0 1 2.586368970351089 0.0096993040306692 | |
| The citric acid tca cycle and respiratory electron transport 72 133 2.5843324248414605 0.0097567704513279 | |
| Negative regulation of tcf dependent signaling by dvl interacting proteins 1 1 -2.5808619330382263 0.00985539882556 | |
| Cell death signalling via nrage nrif and nade 10 25 -2.5782596111610587 0.0099299363520231 | |
| Nrage signals death through jnk 9 19 -2.569474780490872 0.010185280513669 | |
| Apoptosis induced dna fragmentation 8 11 2.563766108962187 0.0103543293422083 | |
| Rna polymerase ii transcription termination 38 58 2.559690257321808 0.0104765492384861 | |
| Beta oxidation of decanoyl coa to octanoyl coa coa 4 6 2.5574337747542453 0.0105447634226976 | |
| Elevation of cytosolic ca2 levels 2 2 -2.5517298345639783 0.0107189600174768 | |
| Synthesis of 5 eicosatetraenoic acids 0 1 2.546776229577532 0.0108723125843634 | |
| Polymerase switching 10 15 2.5437434660065064 0.0109671597158151 | |
| Mrna editing c to u conversion 1 1 -2.5419059521919616 0.0110249834556368 | |
| Ras signaling downstream of nf1 loss of function variants 1 2 -2.5418632235012386 0.0110263312785412 | |
| Translesion synthesis by polh 11 13 2.535698781522656 0.0112223216782629 | |
| Deadenylation dependent mrna decay 27 52 2.527302478277297 0.0114942459494453 | |
| Defective lfng causes scdo3 1 1 -2.522889265693391 0.0116395046957014 | |
| Synthesis of lipoxins lx 0 1 2.5195867988587186 0.0117492668145007 | |
| Mrna splicing minor pathway 28 42 2.5143624241215914 0.0119247818162779 | |
| Sumoylation 45 112 2.513748809720706 0.0119455482439319 | |
| Phase 2 plateau phase 1 1 -2.5080689659008764 0.0121392971595111 | |
| Phase 3 rapid repolarisation 1 1 -2.5080689659008764 0.0121392971595111 | |
| Pou5f1 oct4 sox2 nanog repress genes related to differentiation 2 2 -2.504508024657632 0.0122621823624449 | |
| Cristae formation 16 25 2.491784353683097 0.0127103181128327 | |
| Beta oxidation of hexanoyl coa to butanoyl coa 3 5 2.4900367708257893 0.0127729879635902 | |
| Post translational protein modification 221 642 2.482061098393937 0.0130624875784992 | |
| Mitochondrial protein import 24 48 2.476076432206553 0.0132835137674682 | |
| Pten regulation 44 95 2.463052411487753 0.0137759776610906 | |
| Gene silencing by rna 41 60 2.458186259958842 0.0139640729217269 | |
| Diseases of signal transduction by growth factor receptors and second messengers 102 211 2.45745811908648 0.0139924124711887 | |
| C type lectin receptors clrs 36 77 2.4517575184055618 0.0142160423839776 | |
| Pyrimidine catabolism 1 2 -2.4451670679744173 0.0144785055788645 | |
| Lagging strand synthesis 15 22 2.443276704418005 0.0145545732627163 | |
| Signaling by wnt 65 125 2.436552601936026 0.0148280126440538 | |
| Apoptotic cleavage of cell adhesion proteins 3 7 2.429794201166112 0.0151073983202101 | |
| Lysine catabolism 5 7 2.421871011377528 0.015440830225379 | |
| Interferon signaling 58 84 2.412437490832508 0.0158462544176345 | |
| Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 8 13 -2.409788993493314 0.0159617490709522 | |
| Irf3 mediated induction of type i ifn 4 6 2.4095494287828654 0.0159722323275577 | |
| Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis 1 2 -2.403892625195549 0.0162215371316167 | |
| Ptk6 regulates proteins involved in rna processing 1 3 2.394239226665082 0.0166548819529803 | |
| Cell cycle checkpoints 74 207 2.391700263942873 0.0167705319907631 | |
| Resolution of ap sites via the multiple nucleotide patch replacement pathway 21 26 2.391507073951303 0.0167793606107631 | |
| Synthesis of wybutosine at g37 of trna phe 2 2 -2.391048444055207 0.0168003359533761 | |
| Cell cycle mitotic 180 374 2.3875690043427653 0.0169602185045489 | |
| Trail signaling 2 2 -2.3795229890441907 0.0173350616911549 | |
| Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway 1 1 -2.3778217001862725 0.0174152445323749 | |
| Golgi cisternae pericentriolar stack reorganization 10 12 2.3770367353295945 0.017452349945759 | |
| Chondroitin sulfate biosynthesis 3 3 -2.3721700593201254 0.0176839493137006 | |
| Lgi adam interactions 0 1 2.371793707334185 0.0177019711560402 | |
| Scavenging of heme from plasma 1 1 -2.368134960193136 0.017878013015987 | |
| Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 31 38 2.363547779600198 0.01810089242282 | |
| Copi dependent golgi to er retrograde traffic 42 65 2.3556479595740583 0.0184904317109309 | |
| Olfactory signaling pathway 2 2 -2.355461962645954 0.0184996909254926 | |
| Sumo is transferred from e1 to e2 ube2i ubc9 1 3 2.354860773320941 0.0185296468189815 | |
| Sumo is conjugated to e1 uba2 sae1 1 3 2.354860773320941 0.0185296468189815 | |
| Phospholipase c mediated cascade fgfr2 0 1 2.351556444432455 0.0186950529757574 | |
| Phospholipase c mediated cascade fgfr4 0 1 2.351556444432455 0.0186950529757574 | |
| Deubiquitination 62 141 2.3407659410164614 0.0192442273662305 | |
| Translesion synthesis by y family dna polymerases bypasses lesions on dna template 15 26 2.3375429545724984 0.0194109701641909 | |
| Signaling by notch1 hd domain mutants in cancer 2 2 -2.3323001924938733 0.0196849044161777 | |
| Zinc transporters 3 6 -2.326036432035739 0.0200166072083689 | |
| Metal ion slc transporters 3 6 -2.326036432035739 0.0200166072083689 | |
| Base excision repair 27 37 2.3212995775412875 0.0202706810266146 | |
| Sumoylation of chromatin organization proteins 25 49 2.3202088364141087 0.0203295828176068 | |
| Activation of the ap 1 family of transcription factors 3 6 -2.3184403370280844 0.020425401972361 | |
| Defects in biotin btn metabolism 5 7 2.3177092359224094 0.0204651287376256 | |
| Innate immune system 168 440 2.314921054979349 0.0206172528635111 | |
| Death receptor signalling 25 56 -2.306425604762367 0.0210868626498426 | |
| Cell cycle 246 454 2.2985278070746498 0.0215317671095018 | |
| Mitotic telophase cytokinesis 10 13 2.2920363166809943 0.0219035476360851 | |
| Wnt5a dependent internalization of fzd2 fzd5 and ror2 6 8 2.291234658939316 0.021949845411719 | |
| Nef mediated cd4 down regulation 5 6 2.2835483995800074 0.0223980853098928 | |
| Nef mediated cd8 down regulation 5 6 2.2835483995800074 0.0223980853098928 | |
| Electric transmission across gap junctions 2 2 -2.2819038553317843 0.0224950171844344 | |
| Interleukin 17 signaling 18 36 -2.2636469242371757 0.023595839328709 | |
| Fc epsilon receptor fceri signaling 34 78 2.262668343394611 0.0236561416727743 | |
| Pd 1 signaling 1 2 2.2623268190327126 0.0236772186228366 | |
| Pi 3k cascade fgfr3 1 2 2.262326819032702 0.0236772186228373 | |
| Pi 3k cascade fgfr2 1 2 2.262326819032702 0.0236772186228373 | |
| Pi 3k cascade fgfr4 1 2 2.262326819032702 0.0236772186228373 | |
| Pi 3k cascade fgfr1 1 2 2.262326819032702 0.0236772186228373 | |
| Glycosphingolipid metabolism 13 21 2.2474765635547143 0.0246095867361884 | |
| Mitochondrial trna aminoacylation 11 22 2.245255311186597 0.0247517471311979 | |
| Runx1 and foxp3 control the development of regulatory t lymphocytes tregs 1 1 -2.2412255157674994 0.0250114708610178 | |
| Runx1 regulates transcription of genes involved in wnt signaling 1 1 -2.2412255157674994 0.0250114708610178 | |
| Runx1 regulates transcription of genes involved in interleukin signaling 1 1 -2.2412255157674994 0.0250114708610178 | |
| Runx2 regulates chondrocyte maturation 1 1 -2.2412255157674994 0.0250114708610178 | |
| Runx3 regulates immune response and cell migration 1 1 -2.2412255157674994 0.0250114708610178 | |
| Mapk family signaling cascades 56 132 2.2401447085215827 0.0250815298402671 | |
| Pcna dependent long patch base excision repair 15 22 2.235903265602454 0.0253581083634157 | |
| Synthesis of bile acids and bile salts via 24 hydroxycholesterol 1 1 -2.2335748644993934 0.0255110593153333 | |
| Defective chst14 causes eds musculocontractural type 0 1 2.2314019173915454 0.0256545179685305 | |
| Rrna modification in the mitochondrion 3 6 -2.217382234843841 0.0265969826470264 | |
| Gap filling dna repair synthesis and ligation in gg ner 15 22 2.2165684534813863 0.0266525952946428 | |
| Trp channels 1 2 -2.215726066217947 0.0267102685910409 | |
| G alpha q signalling events 12 30 -2.214122073848675 0.0268203825454964 | |
| Pexophagy 2 5 -2.212416722616527 0.0269378844773731 | |
| Negative regulation of flt3 0 2 2.210567001593684 0.0270658359641058 | |
| Hcmv late events 24 50 2.2078579593285435 0.0272541762552269 | |
| Cd209 dc sign signaling 7 14 -2.205119151456503 0.0274457345177774 | |
| P75 ntr receptor mediated signalling 13 37 -2.202107925583377 0.0276576857755861 | |
| Class i mhc mediated antigen processing presentation 77 176 2.198480809205701 0.0279148606571979 | |
| Erythropoietin activates phosphoinositide 3 kinase pi3k 1 1 -2.194125854608868 0.0282263630344545 | |
| Cd22 mediated bcr regulation 1 1 -2.194125854608868 0.0282263630344545 | |
| Hats acetylate histones 26 53 -2.192811879157677 0.0283209357110014 | |
| Beta oxidation of butanoyl coa to acetyl coa 2 4 2.188929668937682 0.0286019522637284 | |
| Rho gtpases activate rhotekin and rhophilins 2 3 -2.187870665479278 0.0286790246290451 | |
| Hdr through mmej alt nhej 6 8 2.1827407899490456 0.0290549042368679 | |
| Cohesin loading onto chromatin 7 10 2.1763130463981364 0.029531860664691 | |
| Signaling by hedgehog 39 87 2.175501179197567 0.0295925798459335 | |
| Deposition of new cenpa containing nucleosomes at the centromere 10 23 -2.1749976679502723 0.0296302911431141 | |
| Glycosaminoglycan metabolism 17 33 -2.172971407072891 0.0297824693642401 | |
| Regulation of gene expression by hypoxia inducible factor 2 3 -2.1719263263774424 0.0298612203786721 | |
| Sumoylation of dna damage response and repair proteins 29 64 2.1713927166175773 0.0299014990039381 | |
| Toll like receptor cascades 28 61 -2.1698900485816788 0.0300151763898444 | |
| Apobec3g mediated resistance to hiv 1 infection 2 3 2.16370238187641 0.0304871980957401 | |
| Regulation of beta cell development 5 10 -2.160652890206731 0.0307221625387752 | |
| Rhog gtpase cycle 22 49 2.1568110622973267 0.0310203888333293 | |
| Inhibition of replication initiation of damaged dna by rb1 e2f1 4 7 2.1514564683290143 0.0314401882483426 | |
| Chylomicron clearance 2 3 -2.1467066540360555 0.0318166427034061 | |
| Met receptor activation 0 1 2.139247257758458 0.0324156487072651 | |
| Na cl dependent neurotransmitter transporters 1 1 -2.130208141265165 0.0331544332285678 | |
| Smad2 smad3 smad4 heterotrimer regulates transcription 8 13 -2.115575099669645 0.0343809614712851 | |
| Copi mediated anterograde transport 49 73 2.1147047583880747 0.0344551185634134 | |
| Plasma lipoprotein assembly 4 8 -2.110315992855678 0.0348311469547488 | |
| Fructose catabolism 1 1 -2.1069561818790747 0.0351213779636427 | |
| Ubiquinol biosynthesis 5 6 -2.0968546782400885 0.036006441582328 | |
| Synthesis of ip2 ip and ins in the cytosol 3 7 -2.0937647185967645 0.0362809445135692 | |
| Pp2a mediated dephosphorylation of key metabolic factors 2 3 2.092061307421841 0.0364330318152406 | |
| Dap12 signaling 6 10 -2.0915802523242992 0.036476080574253 | |
| Dermatan sulfate biosynthesis 2 3 -2.0903175456406515 0.0365892841869868 | |
| Heme degradation 2 5 2.0855334835976103 0.0370209020576468 | |
| Mastl facilitates mitotic progression 3 6 2.078619215409236 0.0376523634079624 | |
| Activation of nima kinases nek9 nek6 nek7 3 5 2.077657875454586 0.0377408815004045 | |
| Presynaptic function of kainate receptors 4 6 -2.0723660743650703 0.0382313147061612 | |
| N glycan antennae elongation 4 4 -2.066956439112513 0.0387382588060183 | |
| Ca dependent events 8 17 -2.0657767803715688 0.0388495615405577 | |
| Rap1 signalling 4 8 -2.0575342991214947 0.039634859150107 | |
| Protein localization 43 111 2.0533977311716014 0.0400340191753736 | |
| Signaling by notch2 4 7 -2.053379811414964 0.0400357557416364 | |
| Transcriptional regulation by runx1 47 99 2.0482016536082788 0.0405402444969742 | |
| Signaling by mapk mutants 1 2 2.046322530333462 0.0407246484382017 | |
| Transport of small molecules 88 234 2.0384411268713176 0.0415058368458391 | |
| Reduction of cytosolic ca levels 2 4 2.0382299349251265 0.0415269431168894 | |
| Nr1h2 and nr1h3 mediated signaling 8 15 -2.029036467543357 0.0424545760748042 | |
| Fgfr2 alternative splicing 9 21 2.0289591291007785 0.0424624533634485 | |
| Sting mediated induction of host immune responses 4 7 2.018152522056799 0.0435753790784514 | |
| Synthesis of pyrophosphates in the cytosol 3 5 -2.016725543186332 0.0437241627813793 | |
| Neurofascin interactions 0 1 2.016593649713573 0.0437379362648735 | |
| Telomere maintenance 32 56 2.0162483252447982 0.0437740154578549 | |
| G protein mediated events 11 25 -2.016082043225477 0.0437913974178107 | |
| Collagen biosynthesis and modifying enzymes 10 12 2.015508379506512 0.0438514089586745 | |
| Fatty acids bound to gpr40 ffar1 regulate insulin secretion 2 3 -2.0141186020494137 0.043997082937458 | |
| Depolymerisation of the nuclear lamina 7 11 2.0103627407697564 0.0443928109294551 | |
| Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 14 43 -2.009276117583652 0.0445078592133316 | |
| Transport of bile salts and organic acids metal ions and amine compounds 5 12 -1.999798580963637 0.0455220178944812 | |
| Diseases of base excision repair 1 1 -1.998807765877308 0.0456291572209788 | |
| Antigen processing ubiquitination proteasome degradation 55 140 1.9929840653779152 0.0462631919774756 | |
| N glycan antennae elongation in the medial trans golgi 6 8 -1.9928750076210784 0.0462751356566759 | |
| Transcription coupled nucleotide excision repair tc ner 37 63 1.992501075532455 0.0463161072937587 | |
| Activated ntrk2 signals through cdk5 1 2 1.9923963708320451 0.0463275852311202 | |
| Iron uptake and transport 13 23 1.9884125622151083 0.0467660805845866 | |
| Glucuronidation 2 3 1.9878933861073649 0.0468234823869604 | |
| Rab regulation of trafficking 20 71 -1.9856879800568352 0.0470679804914524 | |
| Assembly of active lpl and lipc lipase complexes 0 1 1.973569860719132 0.048430673608 | |
| Fceri mediated mapk activation 8 18 -1.963627647683946 0.0495732887251085 | |
| P75ntr signals via nf kb 5 6 -1.9621273657901792 0.049747657623437 | |
| Er to golgi anterograde transport 65 106 1.959018323382424 0.050110640950971 | |
| Toll like receptor tlr1 tlr2 cascade 19 41 -1.9555814788697767 0.0505144764545817 | |
| Toxicity of botulinum toxin type d botd 1 1 -1.9516048949879936 0.050985131642899 | |
| Neurotoxicity of clostridium toxins 1 1 -1.9516048949879936 0.050985131642899 | |
| Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 7 10 -1.9505351990422368 0.0511123622623916 | |
| Hcmv early events 29 62 1.94844104259856 0.0513622129004531 | |
| Gap junction assembly 4 10 -1.947970789885668 0.051418458385064 | |
| Interleukin 1 processing 3 3 -1.94720777955756 0.0515098293969462 | |
| Extension of telomeres 24 41 1.9452012130135028 0.0517507659172946 | |
| Formation of xylulose 5 phosphate 1 3 1.9448355671567776 0.0517947719026015 | |
| Mitochondrial fatty acid beta oxidation of saturated fatty acids 4 8 1.9446996103147012 0.0518111424799605 | |
| Glucagon signaling in metabolic regulation 6 13 -1.9342056206974645 0.0530878516037736 | |
| Vasopressin regulates renal water homeostasis via aquaporins 6 13 -1.9342056206974645 0.0530878516037736 | |
| Sumoylation of dna methylation proteins 4 9 -1.933749306823902 0.0531439582988879 | |
| Aryl hydrocarbon receptor signalling 2 3 1.9336357967325144 0.053157922778714 | |
| Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 3 5 1.929620317684626 0.0536538994740303 | |
| Calcineurin activates nfat 1 3 -1.9288682756348576 0.0537472171154793 | |
| Hsf1 activation 10 18 1.928811043991953 0.0537543242871887 | |
| Tp53 regulates transcription of cell death genes 13 17 -1.9280778455582308 0.053845444176074 | |
| Signaling by rho gtpases miro gtpases and rhobtb3 188 400 1.9219158660404323 0.0546163450796925 | |
| Keratan sulfate biosynthesis 5 6 -1.9214196205736065 0.0546788269171765 | |
| Polymerase switching on the c strand of the telomere 10 19 1.9209053886793983 0.0547436362949862 | |
| Notch4 intracellular domain regulates transcription 3 6 -1.919140947503194 0.0549664985339397 | |
| Termination of translesion dna synthesis 11 23 1.916652637505619 0.0552820760448329 | |
| Maturation of sars cov 1 nucleoprotein 2 4 -1.910332155995247 0.0560904600291582 | |
| Fcgr3a mediated il10 synthesis 9 17 -1.9071470745376464 0.0565015447999868 | |
| Runx3 regulates notch signaling 3 5 -1.9068388741161 0.0565414556352048 | |
| Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells 3 5 -1.9068388741161 0.0565414556352048 | |
| Neddylation 48 114 1.9039695322239416 0.0569141523297946 | |
| Dopamine neurotransmitter release cycle 3 5 -1.9027904744701631 0.0570678906542716 | |
| Dag and ip3 signaling 9 19 -1.90213091240888 0.0571540420721474 | |
| Receptor type tyrosine protein phosphatases 2 4 -1.9005945810606435 0.0573551358527004 | |
| Signaling by wnt in cancer 6 11 1.8982249470580237 0.0576664558534525 | |
| Attachment and entry 2 3 -1.8932436710671852 0.0583254722426658 | |
| Myd88 independent tlr4 cascade 20 46 -1.890729146450721 0.0586605096156878 | |
| Pi metabolism 18 39 -1.8889117827814403 0.0589036503680682 | |
| Pi5p regulates tp53 acetylation 5 8 -1.8866494019204525 0.0592074974113661 | |
| Regulation of tnfr1 signaling 11 16 -1.8851330344679689 0.0594118790387312 | |
| Ptk6 regulates cell cycle 1 2 1.884820613068798 0.0594540610037113 | |
| G protein activation 5 7 -1.883306218364764 0.0596588812027856 | |
| Alk mutants bind tkis 4 7 1.878650196040852 0.0602922723871177 | |
| Signaling by nuclear receptors 30 106 -1.8743393948590188 0.0608836609662932 | |
| Energy dependent regulation of mtor by lkb1 ampk 6 16 -1.8685605273821573 0.0616839817724474 | |
| Sealing of the nuclear envelope ne by escrt iii 5 20 -1.8667042024120584 0.0619429065716716 | |
| Carnitine metabolism 4 6 1.860356391334527 0.0628351201446628 | |
| Cellular senescence 28 83 -1.8590408144357269 0.0630213533969443 | |
| Keratan sulfate degradation 3 5 1.8579338907423524 0.063178402914191 | |
| Insulin receptor recycling 8 11 1.8547938864824705 0.0636256654024536 | |
| Regulation of fzd by ubiquitination 1 1 -1.8531239083338031 0.0638646007384435 | |
| Toll like receptor 9 tlr9 cascade 20 44 -1.837013959404716 0.0662078346478027 | |
| Flt3 signaling by cbl mutants 1 1 -1.8349114327285976 0.0665188134199015 | |
| Signaling by notch3 7 14 -1.83463955756886 0.0665591134044374 | |
| Runx1 regulates transcription of genes involved in bcr signaling 2 2 -1.8337730371311216 0.0666876917030023 | |
| Heme signaling 10 16 -1.8314958442285028 0.067026567425795 | |
| Ire1alpha activates chaperones 16 33 1.8288069020541216 0.067428540650984 | |
| Ptk6 regulates rtks and their effectors akt1 and dok1 2 3 -1.8247353830730857 0.0680409710371989 | |
| Chrebp activates metabolic gene expression 4 5 1.8192432913762104 0.0688743208133535 | |
| Sumo is proteolytically processed 2 2 -1.8164348880752144 0.0693036875025354 | |
| Killing mechanisms 2 4 -1.811867924301877 0.0700066066377615 | |
| Formation of fibrin clot clotting cascade 1 3 1.8110137152397352 0.0701387286409405 | |
| Ntrk2 activates rac1 1 2 -1.8109628746401925 0.0701465986922684 | |
| Scavenging by class f receptors 3 5 1.8107298335762447 0.0701826823861972 | |
| Synthesis of prostaglandins pg and thromboxanes tx 3 4 1.8090158700181345 0.0704485378770489 | |
| Cdc6 association with the orc origin complex 5 10 -1.8088718084927975 0.0704709210665885 | |
| Resolution of d loop structures through synthesis dependent strand annealing sdsa 12 19 -1.8078374815028933 0.0706317983292286 | |
| Resolution of d loop structures 12 19 -1.8078374815028933 0.0706317983292286 | |
| Adaptive immune system 106 301 1.8011789280449853 0.0716746825327225 | |
| Tnf signaling 13 20 -1.800656300202096 0.0717570694106477 | |
| A tetrasaccharide linker sequence is required for gag synthesis 2 3 -1.7986556717530595 0.0720731650492136 | |
| Tysnd1 cleaves peroxisomal proteins 3 6 1.7971508519570654 0.0723116745682499 | |
| Phosphorylation of the apc c 9 14 1.79117909515684 0.0732645597379955 | |
| Flt3 signaling 6 12 -1.7882801789007905 0.073730816080122 | |
| Unwinding of dna 6 12 1.7833287263238176 0.0745328078730183 | |
| Mhc class ii antigen presentation 48 76 1.7794866392958246 0.0751600134198375 | |
| Copi independent golgi to er retrograde traffic 27 36 1.7733945739635657 0.0761633474912888 | |
| Vldl assembly 2 3 -1.7682231462187443 0.0770236061471889 | |
| Met interacts with tns proteins 1 2 1.7673979291675757 0.0771616095169094 | |
| Met activates pi3k akt signaling 1 2 1.7673979291675666 0.0771616095169109 | |
| Zinc efflux and compartmentalization by the slc30 family 3 3 -1.7639858596002886 0.0777343599279998 | |
| Recycling pathway of l1 17 28 1.7628917811381637 0.077918743499739 | |
| Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 9 13 1.7588138954581929 0.0786091238383699 | |
| Sphingolipid metabolism 22 39 1.758336706617828 0.0786902355553822 | |
| Pka mediated phosphorylation of creb 5 9 -1.757622641726261 0.0788117382289395 | |
| Opioid signalling 12 36 -1.753845824897647 0.0794569285606188 | |
| Gdp fucose biosynthesis 2 4 -1.7519610815359368 0.0797805002319014 | |
| Rho gtpases activate ktn1 7 9 1.7453144446891726 0.0809301489247391 | |
| Mitotic g2 g2 m phases 49 135 1.7445406982439269 0.0810648511782772 | |
| Class b 2 secretin family receptors 4 8 -1.7431478136273415 0.0813077984806931 | |
| Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 7 13 1.741658768234032 0.0815681713559723 | |
| Tyrosine catabolism 1 2 1.7414042068537992 0.081612751327015 | |
| Uptake and function of diphtheria toxin 3 4 1.74010431702608 0.0818407023699689 | |
| P75ntr regulates axonogenesis 1 3 1.7396205052005702 0.0819256762659461 | |
| Chondroitin sulfate dermatan sulfate metabolism 7 11 -1.7332315861814624 0.0830545150223052 | |
| Dual incision in gg ner 18 31 1.7327107553041894 0.0831470919091121 | |
| Diseases associated with n glycosylation of proteins 11 17 -1.7323024176984294 0.0832197317411813 | |
| Notch2 intracellular domain regulates transcription 2 4 -1.7317110404806717 0.0833250239162781 | |
| Wnt ligand biogenesis and trafficking 4 6 1.7311126489060005 0.0834316747791945 | |
| Transport of nucleotide sugars 1 2 -1.728995397713351 0.0838099187742495 | |
| Clec7a inflammasome pathway 4 4 -1.7267612446594856 0.0842105513760331 | |
| Sumoylation of immune response proteins 4 4 -1.7267612446594856 0.0842105513760331 | |
| Advanced glycosylation endproduct receptor signaling 7 9 1.7246256063608114 0.084594965713133 | |
| Signaling by tgfb family members 17 42 -1.722886417412397 0.0849090670502421 | |
| Ethanol oxidation 2 4 1.721726248292392 0.0851191201326451 | |
| Cooperation of prefoldin and tric cct in actin and tubulin folding 11 22 1.712337326967731 0.0868345215826782 | |
| Nuclear events stimulated by alk signaling in cancer 10 13 1.7074383006187204 0.0877406165883307 | |
| P75ntr recruits signalling complexes 2 4 -1.705240969350991 0.0881494919620333 | |
| Telomere c strand lagging strand synthesis 16 28 1.7051079649701557 0.0881742904016702 | |
| Met activates rap1 and rac1 4 6 1.7007161901324193 0.0889962934616963 | |
| Binding of tcf lef ctnnb1 to target gene promoters 1 2 -1.69981627512324 0.0891654892245925 | |
| Runx3 regulates wnt signaling 1 2 -1.69981627512324 0.0891654892245925 | |
| Aquaporin mediated transport 6 14 -1.6940699791733054 0.0902519861703285 | |
| G alpha i signalling events 17 47 -1.6913322746158868 0.0907733591997157 | |
| Dap12 interactions 6 12 -1.6902841156801929 0.0909736124998001 | |
| Er quality control compartment erqc 7 10 -1.6870938305800816 0.091585311158489 | |
| Signaling by notch 41 94 1.6856112846055824 0.091870694257252 | |
| Glucagon like peptide 1 glp1 regulates insulin secretion 7 15 -1.6808746580232763 0.0927872632846382 | |
| Regulation of gene expression in early pancreatic precursor cells 1 1 -1.677746099310563 0.0933966758088187 | |
| Regulation of tp53 activity through acetylation 15 29 -1.6747891307743696 0.0939756122090929 | |
| Cdc42 gtpase cycle 23 66 -1.674021989339511 0.0941262778203564 | |
| Assembly of the hiv virion 5 7 -1.6735618057342896 0.0942167501954709 | |
| Organic anion transporters 1 2 1.6732385130883576 0.0942803514086956 | |
| Triglyceride biosynthesis 0 1 1.669528430300755 0.0950127008591197 | |
| Meiotic synapsis 13 20 1.66839445122145 0.0952374490520977 | |
| Adp signalling through p2y purinoceptor 1 6 9 -1.6678264665407945 0.0953501803246492 | |
| Ros and rns production in phagocytes 7 10 1.6676245471243374 0.0953902822022705 | |
| Synthesis of ip3 and ip4 in the cytosol 4 8 -1.6669975432168571 0.0955148933896252 | |
| Processing of smdt1 8 14 1.6640921097262258 0.0960940236153899 | |
| Phosphorylation of emi1 2 4 1.6638373110280331 0.0961449455205623 | |
| Stimuli sensing channels 8 19 -1.662953544810795 0.0963217349035752 | |
| G alpha s signalling events 9 15 -1.6613105198853666 0.0966510982993882 | |
| Runx2 regulates osteoblast differentiation 5 10 -1.6584108703411502 0.0972345639957128 | |
| Collagen degradation 4 4 -1.6536695563871924 0.0981946715050465 | |
| Complement cascade 3 5 -1.6523322563446885 0.0984668371160197 | |
| Rho gtpase cycle 85 247 1.647109609805544 0.099535518245206 | |
| Visual phototransduction 7 19 -1.6456709637835334 0.0998315201810751 | |
| Synthesis of dolichyl phosphate 3 5 -1.643228331937968 0.1003357000620404 | |
| Nectin necl trans heterodimerization 2 3 -1.642200217160795 0.100548517716984 | |
| Competing endogenous rnas cernas regulate pten translation 3 4 -1.6373914042137343 0.1015487131254921 | |
| Regulation of pten mrna translation 3 4 -1.6373914042137343 0.1015487131254921 | |
| Signaling by mst1 1 1 -1.637262167377966 0.1015757022989909 | |
| Activated tak1 mediates p38 mapk activation 7 11 -1.6354283676589196 0.1019592796920196 | |
| Signaling by tgf beta receptor complex in cancer 2 3 -1.6291569453031842 0.1032797987652693 | |
| Arms mediated activation 0 3 1.625308673189591 0.1040968043098216 | |
| Branched chain amino acid catabolism 9 19 1.6229644931779474 0.1045969953703385 | |
| Ikba variant leads to eda id 5 6 -1.6215980063706037 0.1048894498117292 | |
| Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet 1 1 -1.6210332109056054 0.105010516335088 | |
| Biosynthesis of maresins 1 1 -1.6210332109056054 0.105010516335088 | |
| Transcriptional activation of mitochondrial biogenesis 9 25 -1.6209165778615646 0.1050355309806172 | |
| Acyl chain remodelling of pe 3 3 -1.618634718984063 0.1055258803378131 | |
| Glycogen metabolism 6 13 1.618547598506592 0.1055446376176965 | |
| The role of nef in hiv 1 replication and disease pathogenesis 11 16 1.616986864957288 0.1058811162398605 | |
| Erythrocytes take up carbon dioxide and release oxygen 1 1 -1.6152323707658316 0.1062603829165129 | |
| Esr mediated signaling 23 80 -1.614961360769084 0.1063190627090597 | |
| Late endosomal microautophagy 9 21 -1.61386773321931 0.1065561188606336 | |
| Maturation of sars cov 1 spike protein 3 5 1.6135673717656425 0.1066212988870534 | |
| Glutamate and glutamine metabolism 6 9 1.60681153352454 0.1080957174171635 | |
| Synthesis of glycosylphosphatidylinositol gpi 4 4 -1.6031454254577295 0.1089025510373078 | |
| Nf kb is activated and signals survival 4 5 -1.6012494772896266 0.1093216742290479 | |
| Regulated necrosis 8 28 1.6010534570092494 0.109365079625026 | |
| Antigen presentation folding assembly and peptide loading of class i mhc 10 22 1.6008232122121566 0.1094160808653905 | |
| Rhob gtpase cycle 15 46 -1.5976436588797738 0.1101223041941454 | |
| Perk regulates gene expression 10 18 1.5958357485315957 0.1105254696230326 | |
| Potassium channels 3 5 -1.5927474417684415 0.1112168600361431 | |
| Prostacyclin signalling through prostacyclin receptor 3 5 -1.5927474417684415 0.1112168600361431 | |
| Inwardly rectifying k channels 3 5 -1.5927474417684415 0.1112168600361431 | |
| Glucagon type ligand receptors 3 5 -1.5927474417684415 0.1112168600361431 | |
| Hiv transcription initiation 12 30 -1.5890446897684412 0.1120503035931426 | |
| Pyruvate metabolism 10 20 1.5887627760944651 0.1121139601299869 | |
| Adora2b mediated anti inflammatory cytokines production 7 18 -1.5865699290389903 0.1126100825606795 | |
| Dna damage bypass 17 34 1.584399179764787 0.1131029084682564 | |
| Met activates ptpn11 2 3 1.5739265962834088 0.1155044203873165 | |
| G beta gamma signalling through pi3kgamma 5 9 -1.5676812001066518 0.1169555512670645 | |
| Synthesis of very long chain fatty acyl coas 5 10 1.567031678090425 0.1171072872873084 | |
| Fceri mediated ca 2 mobilization 5 10 -1.5630712094625456 0.1180358465651989 | |
| Sumoylation of intracellular receptors 4 5 -1.5627808488018418 0.118104150240347 | |
| Synthesis of pips at the plasma membrane 8 23 -1.5607855295128756 0.1185743628165476 | |
| Neurotransmitter receptors and postsynaptic signal transmission 18 65 -1.5545610544828496 0.120050645184258 | |
| Gpcr ligand binding 8 19 -1.5471089533567133 0.1218369753290524 | |
| Akt phosphorylates targets in the nucleus 3 5 -1.5448116720981675 0.1223918231890155 | |
| Ngf stimulated transcription 4 7 -1.5424376431137148 0.1229672800202776 | |
| Fcgr activation 2 4 -1.5420346884621907 0.1230651643516569 | |
| Apc c cdc20 mediated degradation of cyclin b 8 14 1.5397172415396247 0.1236292922407031 | |
| Recycling of eif2 gdp 5 8 1.5357148017602371 0.1246083431823708 | |
| Retrograde neurotrophin signalling 7 10 1.5338614041221577 0.1250637528470004 | |
| Synthesis of pips at the early endosome membrane 7 12 -1.53368517012928 0.1251071238471295 | |
| Interleukin 10 signaling 2 3 -1.5324544748882811 0.1254103235632508 | |
| Transferrin endocytosis and recycling 9 13 1.5294338210474718 0.1261569334110999 | |
| Transport of connexons to the plasma membrane 3 9 -1.5286586997279474 0.1263490758576513 | |
| Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 8 15 1.5286572538097356 0.126349434494704 | |
| Apc cdc20 mediated degradation of nek2a 8 15 1.5286572538097356 0.126349434494704 | |
| Slc mediated transmembrane transport 12 45 -1.5277431043199854 0.126576333478654 | |
| P38mapk events 5 7 -1.5164755900969724 0.1293991380470385 | |
| Activation of caspases through apoptosome mediated cleavage 3 4 -1.5098223061595244 0.1310887716700224 | |
| Transcriptional regulation by e2f6 12 22 -1.5028598754611644 0.1328751818521452 | |
| Tp53 regulates transcription of genes involved in cytochrome c release 7 8 -1.4986726616811343 0.1339585722806666 | |
| Ksrp khsrp binds and destabilizes mrna 8 16 1.4980531534113448 0.1341194410629858 | |
| Hiv life cycle 37 117 1.4944817763713016 0.1350497415780023 | |
| Extra nuclear estrogen signaling 14 28 -1.4855555903336015 0.1373967090747641 | |
| Alpha oxidation of phytanate 3 5 1.483168871207589 0.1380295494813861 | |
| Intra golgi and retrograde golgi to er traffic 79 141 1.4798078754107995 0.1389245263624623 | |
| Shc1 events in egfr signaling 3 4 -1.4712576165952176 0.1412214607164439 | |
| N glycan trimming and elongation in the cis golgi 4 4 -1.4689557683699552 0.1418447867532792 | |
| Caspase activation via dependence receptors in the absence of ligand 2 4 -1.4686092808093392 0.141938796128977 | |
| Insertion of tail anchored proteins into the endoplasmic reticulum membrane 7 14 1.4685065243305158 0.1419666853256243 | |
| L1cam interactions 29 59 1.466078326439491 0.1426269495219472 | |
| G2 phase 1 3 -1.465595426542281 0.1427585379607903 | |
| Formation of tubulin folding intermediates by cct tric 6 16 1.4649516027789986 0.1429341224698195 | |
| Circadian clock 12 23 -1.4612990686985532 0.1439333853443676 | |
| Estrogen stimulated signaling through prkcz 2 3 -1.4605847138130443 0.1441294438169118 | |
| Dna replication initiation 6 8 1.4596982057463694 0.1443730352501964 | |
| Runx2 regulates bone development 6 12 -1.4593021710191063 0.1444819581354719 | |
| Synthesis of substrates in n glycan biosythesis 11 30 -1.4588305592640582 0.1446117493896923 | |
| Activation of rac1 downstream of nmdars 2 5 -1.4571680225078645 0.1450700052578271 | |
| Trna processing 40 88 1.4551843276145238 0.1456182384869948 | |
| Arachidonic acid metabolism 6 10 1.450452346207174 0.1469324188070835 | |
| Rho gtpases activate pkns 10 26 1.447024916897424 0.1478899450809219 | |
| Surfactant metabolism 3 5 -1.4469639265304324 0.1479070271300377 | |
| Role of second messengers in netrin 1 signaling 0 2 1.4441562823100875 0.148695019220614 | |
| Prolonged erk activation events 4 8 1.4440836026829424 0.1487154599317652 | |
| Fatty acyl coa biosynthesis 9 21 1.4437593214466231 0.1488066882367333 | |
| Anti inflammatory response favouring leishmania parasite infection 10 29 -1.438105300622645 0.1504041788970054 | |
| Shc1 events in erbb2 signaling 3 6 -1.4316450099061004 0.1522454413506007 | |
| Synthesis of active ubiquitin roles of e1 and e2 enzymes 6 13 1.42744685912276 0.1534511322497631 | |
| Endosomal sorting complex required for transport escrt 21 22 -1.4243416983891783 0.1543475822994036 | |
| Ripk1 mediated regulated necrosis 6 15 1.422974907410416 0.1547434294548009 | |
| Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 47 96 1.422848613225156 0.1547800453960339 | |
| Rab gefs exchange gtp for gdp on rabs 15 53 -1.4221372329656066 0.1549864158184728 | |
| Regulation of insulin secretion 9 25 -1.4203981109543655 0.1554918124610531 | |
| Myoclonic epilepsy of lafora 1 2 1.420008568050469 0.1556051866666417 | |
| Fructose metabolism 1 3 1.417815830722051 0.1562445410553339 | |
| Integration of provirus 5 8 1.4169731921796025 0.1564907654189387 | |
| Nade modulates death signalling 0 3 1.415058498092215 0.157051345164088 | |
| Rhod gtpase cycle 23 41 1.4115707782865383 0.158076381633146 | |
| Glutathione conjugation 14 18 1.4076371656395312 0.1592385364202277 | |
| Dual incision in tc ner 26 49 1.4031070674521633 0.1605849139872512 | |
| Pka activation in glucagon signalling 3 8 -1.402292793557856 0.1608278314959825 | |
| Potential therapeutics for sars 21 54 1.401439687408128 0.1610826313067672 | |
| Metabolism of fat soluble vitamins 6 12 -1.397370342021522 0.1623022329199313 | |
| Hiv elongation arrest and recovery 18 27 1.3954552624937138 0.162878596608381 | |
| Infection with mycobacterium tuberculosis 9 16 1.3941737952546585 0.1632651290912024 | |
| Response of mtb to phagocytosis 9 16 1.3941737952546585 0.1632651290912024 | |
| Hcmv infection 31 80 1.393555618566731 0.1634518385236414 | |
| Glycogen breakdown glycogenolysis 4 9 1.3831273743458925 0.1666258134109575 | |
| Signaling by nodal 4 6 -1.3786100148181288 0.1680150270925988 | |
| Notch3 intracellular domain regulates transcription 3 7 -1.3783637674031035 0.1680910042228904 | |
| Signalling to ras 6 9 -1.3768596804841242 0.1685556349689936 | |
| Rho gtpase effectors 99 182 1.3758978372662474 0.1688532649082073 | |
| Protein folding 22 53 1.372196413781518 0.1700023015332759 | |
| Abortive elongation of hiv 1 transcript in the absence of tat 13 19 1.371405161693091 0.170248689300051 | |
| O linked glycosylation 7 12 -1.371290256310075 0.1702844918962991 | |
| Vldlr internalisation and degradation 6 8 1.369876948180006 0.1707253166629727 | |
| N glycan trimming in the er and calnexin calreticulin cycle 10 22 1.3684025966534104 0.1711860919131902 | |
| Vegfr2 mediated cell proliferation 7 10 -1.3670823143193782 0.17159950606544 | |
| Degradation of the extracellular matrix 6 19 -1.3665624690618687 0.1717624877968839 | |
| Signaling by ctnnb1 phospho site mutants 4 9 1.3636776135381712 0.1726690527520018 | |
| Beta catenin phosphorylation cascade 4 9 1.3636776135381712 0.1726690527520018 | |
| Aberrant regulation of mitotic exit in cancer due to rb1 defects 7 13 1.3615706391622355 0.1733334264592689 | |
| Sensory perception 9 44 -1.3592216771292642 0.1740763542180143 | |
| Diseases of glycosylation 23 42 -1.3563627501672797 0.1749837790493518 | |
| Robo receptors bind akap5 2 5 -1.3502455732678125 0.1769372242159104 | |
| Oncogene induced senescence 5 13 -1.349956112254885 0.1770300610170316 | |
| Recognition of dna damage by pcna containing replication complex 11 26 1.349222308633857 0.1772655713039876 | |
| Transcriptional regulation by the ap 2 tfap2 family of transcription factors 6 13 -1.3474865836415646 0.1778235715269362 | |
| Notch3 activation and transmission of signal to the nucleus 4 7 -1.3451793704819686 0.1785673165281756 | |
| Fatty acid metabolism 48 85 1.3435336325523386 0.1790992432234066 | |
| Rsk activation 3 4 1.3429289019245767 0.1792949968098942 | |
| Transcriptional activity of smad2 smad3 smad4 heterotrimer 8 19 -1.34254424793833 0.1794195935060796 | |
| Transport to the golgi and subsequent modification 66 118 1.340265616488804 0.180159005690013 | |
| Deadenylation of mrna 12 22 1.3389386068329223 0.1805906600207656 | |
| Chylomicron assembly 2 4 -1.3382515569312687 0.1808144475771751 | |
| Nuclear receptor transcription pathway 5 8 -1.3362817156125208 0.181457210541601 | |
| Positive epigenetic regulation of rrna expression 17 42 1.3345693228264128 0.1820173439843122 | |
| Synthesis of pi 1 2 1.332011610678555 0.1828563732358403 | |
| Glyoxylate metabolism and glycine degradation 11 17 1.3302292748912423 0.183442741457027 | |
| Signaling by tgf beta receptor complex 14 38 -1.3262205560715774 0.1847666523315116 | |
| Regulation of tp53 activity 43 101 -1.322939418278907 0.185855525275387 | |
| Mrna editing 0 2 1.3228324343952569 0.1858911084628378 | |
| Signaling by erythropoietin 4 8 -1.321057443119576 0.1864822114856674 | |
| Synthesis of pips at the late endosome membrane 5 8 -1.3206318290206716 0.1866241546095408 | |
| Rhoh gtpase cycle 19 30 1.319642906159222 0.186954270466664 | |
| Platelet adhesion to exposed collagen 2 4 -1.3154400717962933 0.1883620456124557 | |
| Collagen formation 12 17 1.3132330631918203 0.1891044260223893 | |
| Formyl peptide receptors bind formyl peptides and many other ligands 2 3 1.3132163967987285 0.1891100403585424 | |
| Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 11 27 1.3107873371130911 0.1899296218847099 | |
| Cooperation of pdcl phlp1 and tric cct in g protein beta folding 6 19 1.3104849800259688 0.1900318221022752 | |
| Antigen activates b cell receptor bcr leading to generation of second messengers 5 8 -1.309078417618274 0.1905077891645412 | |
| Translesion synthesis by polk 8 11 1.307268412365672 0.1911215681647571 | |
| Creb1 phosphorylation through the activation of adenylate cyclase 4 8 -1.3047219958981748 0.1919875287936088 | |
| Tp53 regulates transcription of death receptors and ligands 1 3 1.3025196577199616 0.1927388025004699 | |
| Atf4 activates genes in response to endoplasmic reticulum stress 8 15 1.2972956271758591 0.1945294884009323 | |
| Processing of intronless pre mrnas 12 21 1.2966386017414304 0.1947555640203155 | |
| Hdl assembly 1 3 -1.2965904198375338 0.1947721504946709 | |
| Pka mediated phosphorylation of key metabolic factors 1 3 -1.2965904198375338 0.1947721504946709 | |
| Foxo mediated transcription 7 21 -1.295168519401128 0.1952621020384706 | |
| Tnfr1 induced proapoptotic signaling 3 6 -1.2946261400811867 0.19544923038328 | |
| Activated ntrk2 signals through ras 2 3 -1.294211892955142 0.1955922398852756 | |
| Activated ntrk3 signals through ras 2 3 -1.294211892955142 0.1955922398852756 | |
| Shc1 events in erbb4 signaling 2 3 -1.294211892955142 0.1955922398852756 | |
| Shc mediated cascade fgfr4 2 3 -1.294211892955142 0.1955922398852756 | |
| Shc mediated cascade fgfr1 2 3 -1.294211892955142 0.1955922398852756 | |
| Shc mediated cascade fgfr3 2 3 -1.294211892955142 0.1955922398852756 | |
| Processive synthesis on the lagging strand 9 16 1.2922943226101544 0.196255237351401 | |
| Interferon gamma signaling 8 25 -1.2846591729112655 0.1989114110592766 | |
| Nucleotide excision repair 42 82 1.2832220062778594 0.1994143082831581 | |
| Gpvi mediated activation cascade 4 11 -1.282898478099437 0.1995276461208666 | |
| Estrogen dependent gene expression 14 51 -1.280931571319459 0.200217702367448 | |
| Piwi interacting rna pirna biogenesis 7 12 1.2799237675752848 0.2005719477689371 | |
| Nrif signals cell death from the nucleus 2 4 -1.2718002873721774 0.2034440868479179 | |
| Activation of kainate receptors upon glutamate binding 6 9 -1.267964823751489 0.2048105127357238 | |
| Defective intrinsic pathway for apoptosis 12 19 1.2646468707140144 0.2059979432164058 | |
| Biotin transport and metabolism 6 10 1.2625782713227205 0.2067407807986798 | |
| Sars cov infections 33 95 1.2597153785628792 0.2077720556536095 | |
| Response to elevated platelet cytosolic ca2 19 49 1.2576266506584493 0.2085268104273796 | |
| Oas antiviral response 2 4 1.2550831025658575 0.2094485938416936 | |
| Rho gtpases activate wasps and waves 12 26 1.251638518666004 0.2107016122687977 | |
| Adherens junctions interactions 4 9 1.2457286791951547 0.2128640210239527 | |
| Copii mediated vesicle transport 28 44 1.2455368118909786 0.2129344927928766 | |
| Urea cycle 1 3 -1.2452735803190125 0.213031203656937 | |
| G protein beta gamma signalling 7 13 -1.245061850378599 0.2131090159109481 | |
| Grb2 events in erbb2 signaling 2 3 -1.2445923841911906 0.2132816212401493 | |
| Activation of nmda receptors and postsynaptic events 12 44 -1.243646963278632 0.2136295236555425 | |
| Rna polymerase ii transcribes snrna genes 24 54 -1.2420274347948816 0.2142264399430737 | |
| Transport of vitamins nucleosides and related molecules 5 11 1.2396000325993717 0.2151233686039622 | |
| Mitochondrial translation 34 82 1.2393170097347377 0.215228121858138 | |
| Runx1 regulates estrogen receptor mediated transcription 2 2 -1.2342125749306088 0.2171237028391386 | |
| Cobalamin cbl vitamin b12 transport and metabolism 8 12 -1.229134374019752 0.2190214291222969 | |
| Intraflagellar transport 10 25 -1.226879642341152 0.2198678311055086 | |
| Hsf1 dependent transactivation 9 21 1.226109543227181 0.2201574550657588 | |
| Regulation of runx1 expression and activity 4 9 -1.2254001919760726 0.2204244746437871 | |
| Thrombin signalling through proteinase activated receptors pars 7 13 -1.223279093793746 0.2212243006441028 | |
| Arachidonate production from dag 2 3 1.2212758360160254 0.2219815992631111 | |
| Runx1 regulates expression of components of tight junctions 0 3 1.2197960993701502 0.2225421804485892 | |
| Metabolism of steroids 30 70 1.219412797281488 0.22268755515142 | |
| Regulation of cholesterol biosynthesis by srebp srebf 13 36 1.2183506749608162 0.2230907406303575 | |
| Trif mediated programmed cell death 2 3 -1.2178474221997349 0.223281959475341 | |
| Tlr3 mediated ticam1 dependent programmed cell death 2 3 -1.2178474221997349 0.223281959475341 | |
| Golgi associated vesicle biogenesis 25 44 1.2172430184966174 0.2235117671656803 | |
| Formation of tc ner pre incision complex 22 39 1.2156436241567952 0.2241207084321261 | |
| Diseases of dna repair 12 23 -1.2077035529796456 0.2271613108942065 | |
| Protein ubiquitination 18 37 1.2003551694268115 0.2300014319372485 | |
| Rac1 gtpase cycle 16 81 -1.1972303653029737 0.2312167774104994 | |
| Phosphate bond hydrolysis by nudt proteins 1 4 1.1961155048434655 0.231651487844557 | |
| Mapk targets nuclear events mediated by map kinases 7 17 -1.1937789099529343 0.2325644635804773 | |
| Attachment of gpi anchor to upar 4 5 1.1927865994454885 0.2329529595783475 | |
| Peptide hormone metabolism 11 30 -1.1911009842257292 0.2336139435477036 | |
| Tgf beta receptor signaling in emt epithelial to mesenchymal transition 3 7 -1.187938170906122 0.2348577698176068 | |
| Cargo concentration in the er 13 20 1.184997490350583 0.2360184391782549 | |
| Trafficking and processing of endosomal tlr 2 5 -1.1847381558928471 0.2361209913170681 | |
| Establishment of sister chromatid cohesion 6 10 1.1831379597157778 0.236754475821515 | |
| Respiratory electron transport 38 82 1.1821178572446116 0.2371589397847355 | |
| Transmission across chemical synapses 21 78 -1.180730594204338 0.2377097636684495 | |
| Biosynthesis of specialized proresolving mediators spms 1 3 1.1793182853166055 0.2382714597895672 | |
| Diseases of mitotic cell cycle 10 19 1.1786009503775916 0.2385571130320849 | |
| Antimicrobial peptides 5 7 -1.1629042825309426 0.2448683397030953 | |
| Hur elavl1 binds and stabilizes mrna 3 7 1.1622654993065953 0.2451276361510443 | |
| Telomere c strand synthesis initiation 3 6 1.162057331900563 0.2452121775770415 | |
| Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 3 5 -1.161303746289524 0.2455183965511267 | |
| Neuronal system 24 95 -1.1605494590016092 0.2458251691280017 | |
| Downregulation of smad2 3 smad4 transcriptional activity 4 8 1.1602242816336543 0.2459575033338747 | |
| Signaling by fgfr2 11 32 1.157098089053431 0.2472322873328267 | |
| Signaling by fgfr 11 32 1.157098089053431 0.2472322873328267 | |
| Erk mapk targets 6 11 1.1555650165661806 0.2478591243164973 | |
| Caspase mediated cleavage of cytoskeletal proteins 4 9 1.152930600370054 0.2489388708709203 | |
| Laminin interactions 4 7 -1.1515240069827195 0.2495167246257827 | |
| Endogenous sterols 2 4 -1.1489347536649637 0.2505828857510781 | |
| Repression of wnt target genes 3 7 -1.1465451181054147 0.2515696699680672 | |
| Ecm proteoglycans 5 9 -1.1462790672578076 0.2516797013650398 | |
| Diseases of immune system 5 8 -1.1440291383490433 0.2526115530372614 | |
| Prolactin receptor signaling 3 6 -1.143243774168036 0.2529373922405638 | |
| Displacement of dna glycosylase by apex1 0 4 1.1322056201804456 0.2575479978375368 | |
| Akt phosphorylates targets in the cytosol 8 8 -1.1318258093408504 0.2577076747055231 | |
| Biological oxidations 34 66 1.131334612993527 0.2579142811405752 | |
| Tristetraprolin ttp zfp36 binds and destabilizes mrna 7 16 1.1302742345490548 0.2583606878693967 | |
| 2 ltr circle formation 4 7 1.129917040884888 0.2585111826924056 | |
| Sulfide oxidation to sulfate 2 4 -1.1258173045762343 0.2602428579811269 | |
| Rho gtpases activate paks 8 15 1.1235790201975873 0.261191660490883 | |
| Apex1 independent resolution of ap sites via the single nucleotide replacement pathway 1 3 1.1232856317002295 0.261316204135432 | |
| Camk iv mediated phosphorylation of creb 3 6 -1.12135276689813 0.2621377329644148 | |
| Pentose phosphate pathway 5 11 1.1161633191680305 0.26435223249277 | |
| Formation of the beta catenin tcf transactivating complex 8 20 -1.1156703271520765 0.2645632764523093 | |
| Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 2 6 -1.1105214887783776 0.2667743734952825 | |
| Attenuation phase 8 16 1.1089921386598551 0.2674335733394106 | |
| Amino acid transport across the plasma membrane 3 10 -1.107308916018308 0.2681603907945 | |
| Synthesis of diphthamide eef2 2 6 -1.1070450589359089 0.268274447507737 | |
| Nicotinate metabolism 3 8 -1.1011691711304152 0.2708230364911617 | |
| Disassembly of the destruction complex and recruitment of axin to the membrane 4 10 1.1005064893396352 0.2711115037547436 | |
| Scavenging by class b receptors 1 2 -1.0969474345025685 0.2726643713803796 | |
| Dna double strand break repair 19 92 1.0917504098742647 0.2749428213250651 | |
| Metabolism of folate and pterines 6 11 1.0894458107285925 0.275957339022951 | |
| Traf3 dependent irf activation pathway 5 7 -1.0885949004392053 0.2763325665912344 | |
| Constitutive signaling by akt1 e17k in cancer 4 12 -1.0868501509490698 0.277103039728253 | |
| Phenylalanine metabolism 2 3 1.0817291099524051 0.2793729143017949 | |
| Resolution of sister chromatid cohesion 40 99 1.0809887976419312 0.2797020967648844 | |
| Conversion from apc c cdc20 to apc c cdh1 in late anaphase 6 12 1.0805675819547742 0.2798895094250349 | |
| Interleukin 15 signaling 3 5 -1.076399027909141 0.2817488369376413 | |
| Plasma lipoprotein remodeling 2 4 -1.0742442767174636 0.2827132125799978 | |
| Sema3a plexin repulsion signaling by inhibiting integrin adhesion 2 7 -1.0738894877231924 0.2828722154170004 | |
| Interaction between l1 and ankyrins 2 4 1.0737873772453723 0.2829179886505928 | |
| Phenylalanine and tyrosine metabolism 4 5 1.0724558044753951 0.2835153545010653 | |
| Activated notch1 transmits signal to the nucleus 5 7 -1.0722339150358626 0.2836149807961117 | |
| Immunoregulatory interactions between a lymphoid and a non lymphoid cell 5 12 -1.0696543997103507 0.2847748990327066 | |
| Wnt5a dependent internalization of fzd4 6 12 1.068605344721294 0.2852475391935063 | |
| Muscle contraction 15 40 1.0684300348113656 0.2853265748376534 | |
| Crmps in sema3a signaling 5 11 -1.064911177121692 0.2869161265659448 | |
| Formation of atp by chemiosmotic coupling 8 14 1.0626469218459096 0.287942099791767 | |
| Sumoylation of transcription cofactors 8 25 -1.0555174143287138 0.2911887493055549 | |
| Processive synthesis on the c strand of the telomere 4 16 1.05502708770749 0.2914129363289968 | |
| Ldl remodeling 1 2 -1.0550189577713054 0.2914166544741614 | |
| Notch hlh transcription pathway 4 11 -1.0541768505408518 0.2918019565499818 | |
| Bicarbonate transporters 2 2 -1.052959343184835 0.2923596261562895 | |
| Rrna processing in the mitochondrion 3 10 -1.0493491715262602 0.2940174426810698 | |
| Sensory processing of sound 15 24 1.038027195481713 0.2992573941246887 | |
| Clathrin mediated endocytosis 38 90 1.037288144430635 0.2996015893214709 | |
| Ddx58 ifih1 mediated induction of interferon alpha beta 15 32 -1.0372591308391488 0.2996151070863835 | |
| Oncogenic mapk signaling 21 43 1.0342543653676073 0.3010172646581259 | |
| Ion homeostasis 9 15 1.0318054466835045 0.3021632672093255 | |
| Nod1 2 signaling pathway 14 14 -1.0305462400303316 0.302753657603354 | |
| Dna damage recognition in gg ner 11 27 1.0304722771199328 0.3027883596177871 | |
| Role of lat2 ntal lab on calcium mobilization 2 5 -1.0259616097358568 0.3049096801255482 | |
| Processing of capped intronless pre mrna 14 25 1.025742601914971 0.3050129277079874 | |
| Signaling by braf and raf1 fusions 18 35 1.0250113605153437 0.3053578272903268 | |
| Epigenetic regulation of gene expression 34 68 1.022977130070708 0.3063186591358386 | |
| Factors involved in megakaryocyte development and platelet production 37 69 1.0167640772958275 0.3092656749003779 | |
| Regulation of gene expression in beta cells 3 5 -1.016006064675005 0.3096264985657959 | |
| Synthesis of pe 4 6 -1.015707798965026 0.3097685530574399 | |
| Rhof gtpase cycle 9 33 -1.0153297133065595 0.309948685118629 | |
| Defects in cobalamin b12 metabolism 7 10 -1.0138162087198406 0.3106704595459493 | |
| Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 2 4 1.011349344833136 0.3118492564862576 | |
| Suppression of phagosomal maturation 5 8 1.0095723014231266 0.3127002456281498 | |
| Pi3k akt activation 2 2 -1.0085133155995314 0.3132080985655783 | |
| Serine biosynthesis 2 5 -1.0084428034885509 0.3132419330026161 | |
| Mitotic spindle checkpoint 38 90 1.0081206293988076 0.3133965551973852 | |
| Tfap2 ap 2 family regulates transcription of growth factors and their receptors 2 3 -1.0046763946811383 0.3150526982026305 | |
| Uptake and function of anthrax toxins 4 7 -1.0042309556518374 0.3152673045555212 | |
| Molecules associated with elastic fibres 0 3 0.9974438123933954 0.3185491340552659 | |
| Elastic fibre formation 0 3 0.9974438123933954 0.3185491340552659 | |
| Tight junction interactions 4 5 -0.994970779613376 0.3197504762180205 | |
| Signaling by insulin receptor 15 22 0.9908826728113452 0.3217428740897596 | |
| Homologous dna pairing and strand exchange 15 32 -0.9905366575952056 0.3219118808268 | |
| Global genome nucleotide excision repair gg ner 32 62 0.9891028937967744 0.3226128019384688 | |
| Activation of puma and translocation to mitochondria 0 2 0.9879249664930564 0.3231893971045503 | |
| Regulation of tp53 activity through methylation 3 9 -0.98409542829941 0.3250685945510603 | |
| Traf6 mediated irf7 activation in tlr7 8 or 9 signaling 2 3 -0.9808721106588172 0.3266558122459502 | |
| Molybdenum cofactor biosynthesis 6 6 -0.978858286411056 0.3276500054332345 | |
| Wax and plasmalogen biosynthesis 3 5 0.9773930132048096 0.3283746206243334 | |
| Activation of anterior hox genes in hindbrain development during early embryogenesis 14 34 -0.9758567389280858 0.329135462865614 | |
| Meiosis 20 36 0.9738376414046452 0.3301371600620617 | |
| Runx1 regulates transcription of genes involved in differentiation of myeloid cells 4 4 -0.969757530217454 0.3321673666893097 | |
| Interleukin 20 family signaling 3 6 -0.9684100814544798 0.3328396065481773 | |
| The canonical retinoid cycle in rods twilight vision 2 3 -0.9665695335056672 0.3337592710936594 | |
| G2 m dna replication checkpoint 1 4 0.9657835625053852 0.3341524953127122 | |
| Traf6 mediated irf7 activation 5 8 -0.9653846519406816 0.3343521859900504 | |
| Phospholipid metabolism 33 89 -0.9650235352791836 0.3345330237443151 | |
| Polb dependent long patch base excision repair 2 8 0.9631745567803446 0.3354599312243691 | |
| Purine catabolism 5 10 0.9615879314914432 0.3362566361587356 | |
| Ret signaling 4 12 -0.9604374145153536 0.3368351153807982 | |
| B wich complex positively regulates rrna expression 11 27 0.9595694489683432 0.3372719511769215 | |
| Cargo trafficking to the periciliary membrane 13 28 0.9591405082100608 0.3374879658801961 | |
| Transcriptional regulation of pluripotent stem cells 3 4 -0.948583192555514 0.342832642602966 | |
| Phase ii conjugation of compounds 19 42 0.9475659421013384 0.3433504713501685 | |
| Dcc mediated attractive signaling 6 9 -0.942601371827534 0.3458848378921135 | |
| Trans golgi network vesicle budding 29 56 0.9422012181652822 0.3460896303724066 | |
| Detoxification of reactive oxygen species 7 14 0.942165730861935 0.3461077959557335 | |
| Sensory processing of sound by outer hair cells of the cochlea 11 17 0.941614843371052 0.3463898674563186 | |
| Translation of replicase and assembly of the replication transcription complex 10 10 -0.9405555655345996 0.346932661866369 | |
| Inla mediated entry of listeria monocytogenes into host cells 1 3 0.9371411068065656 0.3486859789544334 | |
| Propionyl coa catabolism 2 5 -0.9339120817416128 0.3503492461249187 | |
| Mitochondrial fatty acid beta oxidation of unsaturated fatty acids 3 5 0.9336143206512486 0.3505028755303043 | |
| Caspase activation via extrinsic apoptotic signalling pathway 2 9 -0.9287420850879708 0.3530227648323789 | |
| G2 m dna damage checkpoint 21 54 0.9267817694556462 0.3540398522048946 | |
| Regulation of tp53 activity through association with co factors 4 6 -0.9267015386894136 0.3540815184220702 | |
| Hiv transcription elongation 21 34 0.9251339206251962 0.3548962505659827 | |
| Egfr interacts with phospholipase c gamma 1 2 -0.9207858868749365 0.3571622247508712 | |
| Bbsome mediated cargo targeting to cilium 5 11 0.9192760877390148 0.3579511819105301 | |
| Lrr flii interacting protein 1 lrrfip1 activates type i ifn production 3 4 -0.9178812380423949 0.3586810451685569 | |
| Smooth muscle contraction 6 17 0.9154379237305544 0.3599617769978038 | |
| Maturation of protein 3a 1 2 -0.9131467304793116 0.3611653758763629 | |
| Chromatin modifying enzymes 38 132 -0.9085935446578342 0.3635647153135688 | |
| Translocation of slc2a4 glut4 to the plasma membrane 29 53 0.905407883766484 0.3652493406608919 | |
| Ephrin signaling 6 11 -0.905245493709952 0.3653353453344166 | |
| Acetylcholine regulates insulin secretion 4 5 -0.9051605626082556 0.3653803313980934 | |
| Miscellaneous transport and binding events 4 12 -0.904290301528082 0.3658414880742171 | |
| Activated ntrk2 signals through fyn 2 3 -0.8974829898726746 0.3694612461269633 | |
| Ptk6 regulates rho gtpases ras gtpase and map kinases 4 9 -0.8970707834584305 0.3696811476821187 | |
| Irf3 mediated activation of type 1 ifn 0 2 0.8944232827143082 0.3710954598260696 | |
| Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 6 21 -0.8860197298914095 0.3756068955408593 | |
| Trna modification in the nucleus and cytosol 11 29 -0.8847335534963522 0.3763003543169367 | |
| Cd28 dependent pi3k akt signaling 5 7 -0.8775103519479086 0.3802094985968578 | |
| Transcriptional regulation of granulopoiesis 5 14 -0.8743097593186128 0.3819495859667237 | |
| Constitutive signaling by overexpressed erbb2 2 6 0.8722286156530261 0.3830836715235972 | |
| Reproduction 20 37 0.8665719717071967 0.3861765761578206 | |
| Cell junction organization 10 27 0.8658848492425506 0.3865533124111249 | |
| Phase i functionalization of compounds 9 22 0.863050227646611 0.3881098517004111 | |
| Glutamate neurotransmitter release cycle 2 6 -0.8630342892318085 0.3881186145390507 | |
| Creb phosphorylation 3 5 -0.8614038399653355 0.3890156618827263 | |
| Runx3 regulates cdkn1a transcription 0 2 0.8599660415543573 0.3898077619114832 | |
| Formation of rna pol ii elongation complex 22 45 0.8579176683437879 0.3909379272832571 | |
| Nicotinamide salvaging 2 5 -0.8552894320184421 0.3923909365644111 | |
| Metabolism of nitric oxide nos3 activation and regulation 4 9 0.8527782683942094 0.3937822773951609 | |
| Thromboxane signalling through tp receptor 3 9 -0.8489888369095954 0.3958875039238332 | |
| Ldl clearance 10 16 0.8484425472744428 0.3961915559371736 | |
| Signaling by fgfr2 iiia tm 8 13 0.8484346648499309 0.3961959441416878 | |
| Fgfr2 mutant receptor activation 8 13 0.8484346648499309 0.3961959441416878 | |
| Endosomal vacuolar pathway 3 7 -0.8483096886380862 0.396265523252201 | |
| Pink1 prkn mediated mitophagy 7 12 0.8470229094976576 0.3969823521210418 | |
| Rho gtpases activate rocks 10 13 0.8461441280822535 0.3974723460512444 | |
| Dna damage reversal 3 6 0.8408299267630921 0.4004432190732454 | |
| Hyaluronan metabolism 2 6 0.8348329670209101 0.4038117612599359 | |
| Hyaluronan uptake and degradation 2 6 0.8348329670209094 0.4038117612599363 | |
| Processing and activation of sumo 1 4 0.8324642900320977 0.4051469265872016 | |
| Interleukin 23 signaling 1 3 -0.8283622759402558 0.4074653639644263 | |
| Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members 1 2 -0.8236075432780291 0.4101625884731175 | |
| Activation of gene expression by srebf srebp 9 27 0.8229016075418368 0.4105639484814047 | |
| G1 s specific transcription 8 15 0.819038530861633 0.4127644305331153 | |
| Regulation of pten gene transcription 9 39 -0.8172094717939689 0.4138087305539288 | |
| Fcgamma receptor fcgr dependent phagocytosis 19 52 0.8160001151947874 0.4145000698282661 | |
| Clec7a dectin 1 induces nfat activation 2 4 -0.8117845930241099 0.4169152441877641 | |
| Estrogen dependent nuclear events downstream of esr membrane signaling 6 10 -0.8073125887614786 0.4194864130062516 | |
| Pi3k akt signaling in cancer 6 22 -0.8058159524353572 0.42034897849346 | |
| Condensation of prophase chromosomes 7 15 0.8037758879301777 0.4215264175362447 | |
| Other interleukin signaling 2 7 -0.8001094177697469 0.4236474051342109 | |
| Heparan sulfate heparin hs gag metabolism 5 11 -0.7979546194244508 0.4248968253769889 | |
| Regulation of mecp2 expression and activity 6 20 -0.7975694730722526 0.4251203719787966 | |
| Grb2 sos provides linkage to mapk signaling for integrins 1 4 0.7938609069410419 0.4272764102840432 | |
| Signaling by erbb2 6 22 -0.7937910369621503 0.4273170914356974 | |
| Glutathione synthesis and recycling 5 7 0.7935487654459877 0.4274581692701189 | |
| Early phase of hiv life cycle 6 11 0.7922819477230824 0.4281962952732936 | |
| Hdms demethylate histones 5 15 -0.791901132124788 0.4284183268047292 | |
| Negative regulation of met activity 4 13 -0.7917929376366055 0.4284814209643628 | |
| Erks are inactivated 4 8 0.789860330303965 0.4296093409855073 | |
| Notch2 activation and transmission of signal to the nucleus 2 4 -0.7887811973571596 0.4302399008922841 | |
| Retrograde transport at the trans golgi network 19 37 -0.788765197862988 0.4302492537709645 | |
| Regulated proteolysis of p75ntr 4 5 -0.7859941310749067 0.4318709254630117 | |
| Ikk complex recruitment mediated by rip1 7 7 -0.7841566094740995 0.4329482219311251 | |
| Shc related events triggered by igf1r 3 4 -0.782996347007967 0.433629257203304 | |
| Mecp2 regulates transcription factors 1 2 -0.7813381519708632 0.4346036366101349 | |
| Activation of the pre replicative complex 15 30 0.7802633880610862 0.4352358582350242 | |
| Signaling by alk 4 11 -0.7800496120184568 0.4353616736033543 | |
| Mrna decay by 5 to 3 exoribonuclease 13 14 0.7795707686973903 0.4356435673246674 | |
| Cell cell communication 15 45 0.7770035248776667 0.437156690703637 | |
| Eph ephrin signaling 20 48 0.776671848835607 0.4373523997238306 | |
| Signaling by bmp 2 3 -0.7760154531394058 0.4377398616971204 | |
| Signaling by vegf 18 56 -0.7748228402578792 0.4384443509491369 | |
| Transport and synthesis of paps 1 3 0.7734159307711831 0.4392762648302017 | |
| Irak1 recruits ikk complex 3 6 -0.7731780806756049 0.4394169965162402 | |
| Signaling by egfr 8 23 -0.7726484905983245 0.4397304385483069 | |
| Negative regulation of nmda receptor mediated neuronal transmission 11 11 -0.7708976639066086 0.4407675919285605 | |
| Gaba b receptor activation 3 9 -0.7702430531063901 0.4411557296241817 | |
| Trna processing in the mitochondrion 3 5 0.7682855539050006 0.4423175551982199 | |
| Cytosolic sulfonation of small molecules 2 9 -0.7680229237362932 0.4424735659643903 | |
| Methylation 5 11 0.7674189017092743 0.4428324938910868 | |
| Cardiac conduction 9 17 0.76540908890067 0.4440279824760065 | |
| Erbb2 regulates cell motility 2 4 -0.7650822552653282 0.4442225656024758 | |
| Complex i biogenesis 19 46 0.7579928921337746 0.4484552378890623 | |
| Vitamin b1 thiamin metabolism 1 2 -0.7560968234148373 0.4495911463903459 | |
| Glycerophospholipid catabolism 3 3 -0.7539580414797761 0.450874416805525 | |
| Other semaphorin interactions 0 2 0.7500943959578231 0.4531978544535697 | |
| Chaperone mediated autophagy 5 11 0.7490375432348585 0.4538345774450762 | |
| Signaling by met 8 32 -0.7485126360023788 0.4541510062026948 | |
| Signaling by fgfr2 in disease 8 16 0.7402920923855032 0.4591227780860349 | |
| Activation of ampk downstream of nmdars 4 13 -0.7380178155489487 0.4605036231189121 | |
| Signaling by ntrk3 trkc 4 8 -0.7330789530414734 0.463510276152475 | |
| Erythropoietin activates phospholipase c gamma plcg 1 3 -0.7287815758993053 0.4661352833366678 | |
| Cytochrome p450 arranged by substrate type 2 5 -0.7282154488545546 0.4664817103350407 | |
| Rhoc gtpase cycle 15 54 -0.7281636290401862 0.4665134272850273 | |
| Defective ripk1 mediated regulated necrosis 3 4 -0.7260614374878807 0.4678011079157911 | |
| Tp53 regulates transcription of dna repair genes 21 47 0.7210288428633859 0.4708917690911467 | |
| Sars cov 1 infection 9 27 -0.7208140541673295 0.4710239272680132 | |
| Activation of bad and translocation to mitochondria 4 11 0.720456636133212 0.4712438897631366 | |
| Sirt1 negatively regulates rrna expression 2 7 -0.7197529584223672 0.4716771132072577 | |
| Nucleotide catabolism 6 13 0.7179647725408104 0.4727790079381706 | |
| Coenzyme a biosynthesis 2 5 -0.7171600250414694 0.4732753618970493 | |
| Ticam1 rip1 mediated ikk complex recruitment 6 6 -0.7166494600182656 0.473590417908845 | |
| Diseases of carbohydrate metabolism 4 14 0.7147494664196329 0.4747638656820725 | |
| Parasite infection 14 39 0.7120940814508797 0.4764065190326765 | |
| Formation of apoptosome 5 8 -0.709376289132763 0.4780909977447356 | |
| Trafficking of glur2 containing ampa receptors 5 9 0.708130760814728 0.4788640587041721 | |
| Mitophagy 10 18 0.7080597763823399 0.4789081371005075 | |
| Sema4d induced cell migration and growth cone collapse 3 10 -0.705920876804223 0.4802373438987359 | |
| Rhoa gtpase cycle 22 81 -0.7017316185432684 0.4828465507249049 | |
| Activation of noxa and translocation to mitochondria 1 2 -0.7014719737348362 0.4830085190320785 | |
| Ras processing 3 9 -0.6987227580111726 0.4847253085813476 | |
| Signaling by retinoic acid 3 18 -0.6982154428771299 0.485042470198227 | |
| G beta gamma signalling through cdc42 4 8 -0.6967504388655986 0.4859589872154475 | |
| Vxpx cargo targeting to cilium 5 12 0.6964567194392 0.486142852869877 | |
| Map3k8 tpl2 dependent mapk1 3 activation 5 10 -0.6948305241612022 0.4871615165667902 | |
| Butyrate response factor 1 brf1 binds and destabilizes mrna 7 16 0.6944887395969874 0.4873757600739683 | |
| Glycogen synthesis 3 7 0.6932683640634131 0.4881411525919203 | |
| E2f enabled inhibition of pre replication complex formation 4 10 -0.6924263547148725 0.488669619937939 | |
| Diseases of metabolism 35 83 -0.6882382025568952 0.4913027902486764 | |
| Sensing of dna double strand breaks 3 6 0.687348991600693 0.4918628329971259 | |
| Integration of energy metabolism 10 38 -0.6865635587477172 0.4923577990314363 | |
| Ercc6 csb and ehmt2 g9a positively regulate rrna expression 10 19 0.6856706609366434 0.4929208118671189 | |
| Dna double strand break response 6 33 0.6842838430215374 0.4937959474436719 | |
| Myogenesis 3 8 0.682477103254444 0.4949373161100054 | |
| Senescence associated secretory phenotype sasp 16 31 0.6821985704089288 0.4951133985287017 | |
| Signaling by fgfr in disease 18 29 0.6800201354810741 0.4964917114934226 | |
| Telomere extension by telomerase 8 15 0.6793606206808896 0.496909394816875 | |
| Chl1 interactions 1 4 0.6765428699136983 0.4986960372995745 | |
| Ticam1 traf6 dependent induction of tak1 complex 1 2 0.672949676700934 0.5009793067130321 | |
| Irak2 mediated activation of tak1 complex 1 2 0.672949676700934 0.5009793067130321 | |
| Alpha protein kinase 1 signaling pathway 1 2 0.672949676700934 0.5009793067130321 | |
| Plasma lipoprotein assembly remodeling and clearance 6 27 -0.6718464990914165 0.5016814230100706 | |
| Nef mediated downregulation of mhc class i complex cell surface expression 3 7 0.6716177596461691 0.5018270691792399 | |
| Reactions specific to the complex n glycan synthesis pathway 2 4 -0.6713723766100367 0.5019833377657474 | |
| Formation of the early elongation complex 15 25 0.6710472084887401 0.5021904559765613 | |
| Pkmts methylate histone lysines 13 30 -0.6708123613041893 0.502340071717783 | |
| Rab geranylgeranylation 9 39 -0.6706818727690738 0.5024232131507147 | |
| Costimulation by the cd28 family 9 23 0.6688335190133686 0.5036016822991789 | |
| Gaba receptor activation 3 10 -0.6664686830088962 0.5051115744103032 | |
| Signaling by activin 3 5 -0.6537196720294527 0.5132924269089381 | |
| G alpha z signalling events 6 12 -0.6526003403761897 0.5140139660805025 | |
| Activation of smo 3 5 -0.6519833860279315 0.5144118901998314 | |
| Autophagy 28 93 -0.6513683531008444 0.5148087343858694 | |
| Rho gtpases activate cit 9 13 0.6499787353413959 0.5157059575005909 | |
| Linoleic acid la metabolism 2 4 -0.6494520035905874 0.5160462600309725 | |
| Cytochrome c mediated apoptotic response 6 10 -0.6484863987721065 0.5166704050681523 | |
| Interleukin receptor shc signaling 4 5 -0.6483741601607966 0.5167429789277675 | |
| Keratan sulfate keratin metabolism 6 11 -0.6471647589108208 0.5175253167594023 | |
| Tbc rabgaps 6 28 -0.6467924797852277 0.5177662601199939 | |
| Mapk1 erk2 activation 2 5 -0.6450383813928732 0.5189023133643849 | |
| Ras activation upon ca2 influx through nmda receptor 9 9 -0.6407231371604104 0.5217025789944167 | |
| Long term potentiation 9 9 -0.6407231371604104 0.5217025789944167 | |
| Regulation of signaling by cbl 1 8 0.6382525413660962 0.523309300036717 | |
| Nostrin mediated enos trafficking 0 2 0.6363150279439944 0.524571111872679 | |
| Regulation of tp53 expression and degradation 4 17 0.634624137427806 0.525673581858126 | |
| Ptk6 expression 0 2 0.6296066104486108 0.5289519975116088 | |
| Anchoring of the basal body to the plasma membrane 14 58 -0.6292026948705731 0.529216364812044 | |
| Metabolic disorders of biological oxidation enzymes 3 9 -0.6269051289797307 0.5307214250313443 | |
| Downregulation of erbb2 erbb3 signaling 2 4 -0.625606583467752 0.5315730195411392 | |
| Cell extracellular matrix interactions 4 10 0.622072054589239 0.5338944895243367 | |
| Abc transporters in lipid homeostasis 2 5 -0.618800550486218 0.5360477595305531 | |
| Kinesins 16 31 0.6176798992465552 0.5367863646151503 | |
| Rac3 gtpase cycle 11 59 -0.6147975995493132 0.5386883947657028 | |
| Binding and uptake of ligands by scavenger receptors 5 11 0.613781937252709 0.5393594348333115 | |
| Fasl cd95l signaling 1 3 -0.6126807891438969 0.54008742745506 | |
| Transport of inorganic cations anions and amino acids oligopeptides 8 20 -0.612189420556054 0.5404124403299146 | |
| Mtor signalling 6 25 -0.6062297359549562 0.5443622094317493 | |
| The activation of arylsulfatases 0 3 0.6057615802603817 0.5446730854551318 | |
| Nef and signal transduction 1 3 -0.6044534083010357 0.5455422366115716 | |
| Runx2 regulates genes involved in cell migration 4 4 -0.5964485990171086 0.5508755823404341 | |
| Mecp2 regulates neuronal receptors and channels 6 9 0.5961067422264705 0.5511039203484662 | |
| Gap junction trafficking and regulation 4 19 -0.5951345496483654 0.5517535357874477 | |
| Egfr transactivation by gastrin 2 4 -0.5924740619972088 0.5535331847149463 | |
| Vegfr2 mediated vascular permeability 6 15 0.5903350159124516 0.5549660681953805 | |
| Regulation of commissural axon pathfinding by slit and robo 2 3 -0.5898339844878611 0.5553019561395018 | |
| Rora activates gene expression 4 7 -0.5830611633424795 0.5598521267442158 | |
| Defects in vitamin and cofactor metabolism 8 17 0.5803974781842809 0.561646605355119 | |
| Traf6 mediated induction of tak1 complex within tlr4 complex 2 3 0.577895306468607 0.5633348042925639 | |
| Assembly and cell surface presentation of nmda receptors 17 18 -0.5775182706305485 0.5635893998713741 | |
| Netrin 1 signaling 10 20 -0.5762066605574806 0.5644755037359261 | |
| Metabolism of porphyrins 6 13 0.5753320607214095 0.565066742478316 | |
| Unblocking of nmda receptors glutamate binding and activation 8 8 -0.5733277668047391 0.5664227882552324 | |
| Tp53 regulates transcription of genes involved in g1 cell cycle arrest 1 3 0.5720140711718026 0.5673124418312518 | |
| Maturation of sars cov 2 spike protein 7 17 0.5713630270964921 0.5677535861524172 | |
| Platelet homeostasis 9 21 -0.5689756940914493 0.5693726348978443 | |
| Diseases of mismatch repair mmr 2 5 -0.5647391088559293 0.5722512291231843 | |
| Organelle biogenesis and maintenance 36 159 -0.5630590952135429 0.5733946441046962 | |
| Pi3k events in erbb2 signaling 1 2 -0.5541952127791818 0.5794452542252286 | |
| Gastrin creb signalling pathway via pkc and mapk 4 10 -0.553902933020053 0.579645277729322 | |
| Trafficking of ampa receptors 8 15 0.5499186126249664 0.5823751974263327 | |
| Sars cov 2 infection 8 42 -0.5489240641289193 0.5830575630207482 | |
| Negative regulation of mapk pathway 4 19 0.548271692585879 0.5835053613932835 | |
| Dna damage telomere stress induced senescence 10 26 0.5480434732144627 0.5836620526888943 | |
| Mismatch repair 9 16 0.5476588328576704 0.5839261841557228 | |
| Runx3 regulates p14 arf 1 4 -0.547653756923776 0.5839296701575292 | |
| Apoptotic factor mediated response 9 15 -0.5451892181453856 0.5856233861558429 | |
| Tp53 regulates transcription of cell cycle genes 8 26 0.5414880448540174 0.5881712356965241 | |
| Adrenaline noradrenaline inhibits insulin secretion 3 7 -0.5392548772135468 0.5897109992784808 | |
| Response of eif2ak1 hri to heme deficiency 2 5 0.5376321331830335 0.5908310415506475 | |
| Sos mediated signalling 1 2 -0.5337922294489403 0.5934852905070618 | |
| Signaling by fgfr3 fusions in cancer 1 2 -0.5337922294489403 0.5934852905070618 | |
| Inhibition of dna recombination at telomere 8 17 0.533734974381558 0.5935249080889831 | |
| Scavenging by class a receptors 3 6 -0.5337023979748359 0.5935474498387614 | |
| Signaling by leptin 1 3 -0.5332598476257459 0.5938537182347394 | |
| Free fatty acids regulate insulin secretion 1 5 0.5308043563661763 0.5955543609296083 | |
| Nucleotide salvage 4 12 0.5298538340597182 0.5962132767417816 | |
| Basigin interactions 3 10 0.5286744529912129 0.597031302152411 | |
| Platelet calcium homeostasis 2 6 0.5259429981189582 0.5989278125495079 | |
| Acyl chain remodelling of pc 2 5 -0.5246190601865837 0.5998480340212309 | |
| Interferon alpha beta signaling 3 15 -0.5234925450647553 0.6006315375380418 | |
| Signaling by kit in disease 4 10 -0.5221554515069785 0.6015621004429947 | |
| Integrin signaling 3 9 0.5200747824670039 0.6030114538477309 | |
| Platelet aggregation plug formation 3 9 0.5200747824670039 0.6030114538477309 | |
| Rhot1 gtpase cycle 1 3 -0.5169889886453519 0.6051638455423101 | |
| Ion transport by p type atpases 5 17 0.5169757492591848 0.6051730876452428 | |
| Interleukin 21 signaling 2 4 -0.5115761076701147 0.6089477104841674 | |
| Interleukin 9 signaling 2 4 -0.5115761076701147 0.6089477104841674 | |
| Post translational modification synthesis of gpi anchored proteins 12 12 -0.5085515312884109 0.6110666100007436 | |
| Ephb mediated forward signaling 3 24 0.5072378383117857 0.611987948593578 | |
| Ncam signaling for neurite out growth 7 13 -0.5072350870537508 0.6119898787914213 | |
| Aggrephagy 15 24 0.5051907122889312 0.6134248930309967 | |
| Fbxw7 mutants and notch1 in cancer 1 3 -0.5045271961814388 0.6138909558742878 | |
| Regulation of tlr by endogenous ligand 2 3 -0.5032222814037857 0.6148080010460037 | |
| Tp53 regulates transcription of caspase activators and caspases 4 5 -0.5018299917828237 0.6157871141914215 | |
| Rhoq gtpase cycle 12 41 -0.497571988022861 0.6187857516061486 | |
| Mrna capping 12 22 0.4952000937170067 0.6204588844793646 | |
| Tryptophan catabolism 1 3 -0.4927833269969002 0.6221656927861423 | |
| Interleukin 3 interleukin 5 and gm csf signaling 4 16 -0.4920077856546382 0.6227138396375564 | |
| Met receptor recycling 1 7 0.4896680973350838 0.6243687804669189 | |
| Metalloprotease dubs 4 11 -0.4874133246580582 0.6259654527373113 | |
| Cyclin a b1 b2 associated events during g2 m transition 8 16 0.4869390232113956 0.6263015435539177 | |
| Tgf beta receptor signaling activates smads 6 15 0.4830498776555214 0.6290603215839607 | |
| Downregulation of tgf beta receptor signaling 5 11 0.4794236025655717 0.6316373057871458 | |
| Suppression of apoptosis 5 6 0.4782851748339549 0.6324472466608675 | |
| Recruitment of mitotic centrosome proteins and complexes 16 58 -0.476458169197508 0.6337480018959192 | |
| Signaling by flt3 itd and tkd mutants 2 4 -0.476235826439332 0.6339063784674666 | |
| Stat5 activation downstream of flt3 itd mutants 1 3 -0.4759393490827084 0.6341175878119449 | |
| Stat5 activation 1 3 -0.4759393490827084 0.6341175878119449 | |
| Enos activation 2 6 0.4735876368576746 0.6357939933673897 | |
| Regulation of pyruvate dehydrogenase pdh complex 3 11 0.4726019023841992 0.6364972249844618 | |
| Inactivation of csf3 g csf signaling 3 9 -0.4675598747992873 0.6400993649403195 | |
| Interleukin 37 signaling 5 7 -0.4671407104907391 0.6403992092826716 | |
| Alpha linolenic omega3 and linoleic omega6 acid metabolism 3 9 0.4650291414983103 0.6419105878491647 | |
| Metabolism of steroid hormones 3 8 0.4605249309867535 0.6451394807359585 | |
| Signaling by csf3 g csf 4 12 -0.4583814800065339 0.6466783947932324 | |
| Tp53 regulates transcription of genes involved in g2 cell cycle arrest 5 13 0.452982792277934 0.6505611324688658 | |
| Degradation of cysteine and homocysteine 4 9 -0.4526989055028778 0.6507655678021389 | |
| Maturation of sars cov 2 nucleoprotein 2 8 -0.4518361482238962 0.651387026257932 | |
| Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 2 13 0.4482020550826325 0.6540073797065995 | |
| Assembly of the orc complex at the origin of replication 4 14 -0.4476723342506287 0.6543896908958546 | |
| Dna methylation 2 7 -0.4475426012258457 0.65448333590244 | |
| Met promotes cell motility 4 12 0.4465833154632107 0.6551759444565524 | |
| Amyloid fiber formation 3 13 -0.4450424545211619 0.6562890738448419 | |
| Cilium assembly 22 106 -0.4410435173254584 0.6591814928929953 | |
| Ra biosynthesis pathway 1 6 -0.4404106045744669 0.6596397457133345 | |
| Ovarian tumor domain proteases 4 15 0.4403063095705928 0.6597152715134298 | |
| Interleukin 2 family signaling 3 8 -0.431892259876566 0.6658197205568848 | |
| Formation of senescence associated heterochromatin foci sahf 6 14 0.4313734160696267 0.6661968762467525 | |
| Beta oxidation of very long chain fatty acids 3 9 -0.4308056061256397 0.6666097229354351 | |
| Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 1 5 -0.4299840977645955 0.6672072089490506 | |
| P130cas linkage to mapk signaling for integrins 0 4 0.4291313745449638 0.6678276209123977 | |
| Metabolism of ingested semet sec mesec into h2se 0 3 0.4263947653834917 0.6698202150810308 | |
| Ionotropic activity of kainate receptors 3 3 -0.4217912408554393 0.6731773996518493 | |
| Nrcam interactions 3 3 -0.4217912408554393 0.6731773996518493 | |
| Downregulation of erbb4 signaling 3 3 -0.4103834281362469 0.6815247008404097 | |
| Microrna mirna biogenesis 4 17 0.4092130923187171 0.6823832872292812 | |
| Mucopolysaccharidoses 2 6 0.4076008111456486 0.6835667686980433 | |
| Formation of the cornified envelope 3 10 0.4014929177216614 0.6880572514053374 | |
| Keratinization 3 10 0.4014929177216614 0.6880572514053374 | |
| Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 5 9 -0.3977692099360879 0.6908003154408051 | |
| Incretin synthesis secretion and inactivation 5 9 -0.3977692099360879 0.6908003154408051 | |
| Leishmania infection 18 73 -0.396219085847082 0.6919434125846415 | |
| Signal attenuation 2 5 -0.3943614832307345 0.6933141763287156 | |
| Bmal1 clock npas2 activates circadian gene expression 4 7 -0.3943438899010947 0.6933271636222509 | |
| Ketone body metabolism 5 6 0.3924640968067809 0.6947153343906209 | |
| Atf6 atf6 alpha activates chaperones 1 3 -0.3914860391245139 0.6954380060877119 | |
| Atf6 atf6 alpha activates chaperone genes 1 3 -0.3914860391245139 0.6954380060877119 | |
| Signaling by erbb4 5 15 -0.389834541478484 0.6966589000670398 | |
| Proton coupled monocarboxylate transport 1 3 -0.3890463792283208 0.6972418379650205 | |
| Regulation of plk1 activity at g2 m transition 14 62 -0.3852103035318405 0.7000816101708995 | |
| Notch4 activation and transmission of signal to the nucleus 1 3 0.3844500688339687 0.7006448968453154 | |
| Cell cell junction organization 4 14 0.3803940292662596 0.7036529460741439 | |
| Negative feedback regulation of mapk pathway 1 5 -0.37828236511814 0.7052208444159453 | |
| Eph ephrin mediated repulsion of cells 6 20 -0.3743730889838959 0.7081267615423585 | |
| Purine salvage 3 9 0.3733250581887017 0.7089065286477381 | |
| Methionine salvage pathway 1 6 0.3725126737591681 0.7095111776008858 | |
| Platelet sensitization by ldl 3 8 0.369718050028122 0.7115925813307586 | |
| Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 2 5 0.3665702086308778 0.7139396336009272 | |
| Rho gtpases activate nadph oxidases 11 11 -0.3665081069347748 0.7139859643779669 | |
| Small interfering rna sirna biogenesis 6 6 -0.3636314704350366 0.7161332232872524 | |
| Pre notch processing in the endoplasmic reticulum 3 3 -0.3620925292378756 0.7172828862135683 | |
| Map2k and mapk activation 9 20 -0.3588472447789067 0.7197093670757855 | |
| Rna polymerase i transcription termination 19 19 -0.358368793181102 0.7200673423205004 | |
| Cd28 dependent vav1 pathway 3 7 0.3559558889429496 0.7218735998958357 | |
| Hs gag degradation 2 5 -0.3540406800295318 0.723308396833922 | |
| Uptake and actions of bacterial toxins 3 12 0.3516372534322997 0.7251103230924769 | |
| Sulfur amino acid metabolism 7 18 -0.3515715929416719 0.7251595722960453 | |
| Regulation of bach1 activity 3 6 -0.3514000345604271 0.725288256469125 | |
| Synaptic adhesion like molecules 4 9 0.3479384412166135 0.7278864149259157 | |
| Regulation of kit signaling 5 7 -0.3478369858137025 0.7279626113884445 | |
| Trafficking of myristoylated proteins to the cilium 1 4 -0.3465798726653442 0.7289069690393923 | |
| Interleukin 4 and interleukin 13 signaling 6 19 -0.3460158338698299 0.7293308152038007 | |
| Hs gag biosynthesis 3 3 -0.3435245106962971 0.7312039045939276 | |
| Carboxyterminal post translational modifications of tubulin 4 11 -0.3430377002344059 0.7315700983318698 | |
| Gap junction degradation 4 8 0.3411335128062441 0.7330030731896746 | |
| Cation coupled chloride cotransporters 2 2 -0.340768301387566 0.7332780155005618 | |
| Acyl chain remodelling of ps 1 3 -0.3400790011113669 0.7337970350184988 | |
| Purinergic signaling in leishmaniasis infection 2 7 0.3399380055099774 0.7339032148785938 | |
| Rhobtb3 atpase cycle 1 6 0.3386952433504717 0.7348393243571296 | |
| Growth hormone receptor signaling 3 8 0.3364222467191596 0.7365524757020905 | |
| Effects of pip2 hydrolysis 2 6 -0.3355598378169916 0.7372028143033529 | |
| Signaling by hippo 3 11 0.3344717026912183 0.73802364053832 | |
| Disinhibition of snare formation 3 4 0.3343306780880075 0.7381300432364091 | |
| Signaling by erbb2 in cancer 3 8 -0.3333263032170381 0.7388879864657014 | |
| Signaling by erbb2 ecd mutants 3 8 -0.3333263032170381 0.7388879864657014 | |
| Interleukin 7 signaling 2 5 -0.3333076586778872 0.7389020588151318 | |
| Pecam1 interactions 7 7 -0.3321671270167715 0.7397630646789926 | |
| G0 and early g1 1 11 0.3312719698272134 0.7404390619383863 | |
| Smac xiap regulated apoptotic response 3 5 -0.3262310052411957 0.7442495846812993 | |
| Miro gtpase cycle 4 6 0.3260844235099006 0.7443604817414422 | |
| Cd163 mediating an anti inflammatory response 2 3 0.3250000650394887 0.7451810224689677 | |
| Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain 5 7 -0.3237578859549149 0.7461213424028337 | |
| Vitamin b2 riboflavin metabolism 2 3 -0.3235632883767924 0.7462686855620002 | |
| Phase 0 rapid depolarisation 3 3 -0.3218957145166612 0.7475316998673176 | |
| Flt3 signaling in disease 2 10 0.3214107920749165 0.7478991057539701 | |
| Signaling by scf kit 4 16 -0.3208449184504949 0.7483279174392661 | |
| Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 2 5 -0.3205551025573436 0.7485475663180874 | |
| Listeria monocytogenes entry into host cells 3 12 0.3181200015255462 0.7503939121071896 | |
| Mecp2 regulates transcription of neuronal ligands 2 4 0.317774680655604 0.7506558578593854 | |
| Constitutive signaling by ligand responsive egfr cancer variants 3 8 -0.3171693597887948 0.7511150979137557 | |
| Signaling by egfr in cancer 3 8 -0.3171693597887948 0.7511150979137557 | |
| Constitutive signaling by egfrviii 3 8 -0.3171693597887943 0.7511150979137562 | |
| Diseases associated with glycosaminoglycan metabolism 7 8 0.3138075677371322 0.7536671963028108 | |
| Signaling by pdgf 6 14 -0.3123128113994185 0.7548028045761104 | |
| Downstream signal transduction 6 14 -0.3123128113994173 0.7548028045761113 | |
| Cell surface interactions at the vascular wall 10 30 -0.3108678558260513 0.7559010818931662 | |
| Tak1 activates nfkb by phosphorylation and activation of ikks complex 8 13 -0.3107591625121864 0.7559837171485773 | |
| Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3 1 6 0.3102752279298977 0.7563516674620423 | |
| Intra golgi traffic 16 29 -0.3089630796915251 0.757349611820767 | |
| Downregulation of erbb2 signaling 3 10 0.3087319522819826 0.7575254359739982 | |
| Dscam interactions 1 5 -0.3078309501200586 0.7582109695973929 | |
| Spry regulation of fgf signaling 3 8 0.3037166851441292 0.7613437452192056 | |
| Negative regulation of fgfr1 signaling 3 8 0.3037166851441292 0.7613437452192056 | |
| Negative regulation of fgfr4 signaling 3 8 0.3037166851441292 0.7613437452192056 | |
| Negative regulation of fgfr3 signaling 3 8 0.3037166851441292 0.7613437452192056 | |
| Negative regulation of fgfr2 signaling 3 8 0.3037166851441292 0.7613437452192056 | |
| Netrin mediated repulsion signals 2 2 -0.3030808761702943 0.7618282277548931 | |
| Erythropoietin activates ras 2 5 -0.3025160035187648 0.7622587355788899 | |
| Recruitment of numa to mitotic centrosomes 17 63 -0.3022436905489307 0.7624663004427683 | |
| Diseases associated with o glycosylation of proteins 3 4 -0.2995994719054617 0.7644826870396588 | |
| Sialic acid metabolism 4 9 -0.2981502796676798 0.7655884679546785 | |
| Synthesis of ketone bodies 4 5 0.2945082851281911 0.7683695333872245 | |
| Heme biosynthesis 2 8 -0.2894346863110694 0.7722487544778807 | |
| The nlrp3 inflammasome 2 8 0.2892011926176912 0.7724274192516698 | |
| Inflammasomes 2 8 0.2892011926176912 0.7724274192516698 | |
| Cytosolic iron sulfur cluster assembly 5 11 -0.2836916690318352 0.7766466796995037 | |
| Calnexin calreticulin cycle 4 15 -0.2831944888930497 0.7770277527388554 | |
| Choline catabolism 2 3 -0.2820313242730233 0.7779194915332024 | |
| Interleukin 6 signaling 2 6 -0.2794469448091924 0.7799018486241007 | |
| Interleukin 6 family signaling 2 6 -0.2794469448091924 0.7799018486241007 | |
| Regulation of localization of foxo transcription factors 3 10 -0.2758891500448908 0.7826332076390945 | |
| Slbp dependent processing of replication dependent histone pre mrnas 2 6 -0.2756038706597754 0.7828523364148119 | |
| Signaling by pdgfr in disease 8 9 0.2753140719202632 0.7830749542375972 | |
| Nuclear events kinase and transcription factor activation 6 19 -0.2697173215294837 0.7873777336058239 | |
| Synthesis of pa 3 16 -0.2691848629400107 0.7877874281300583 | |
| Transcriptional regulation by tp53 48 222 -0.262141049261617 0.7932127002688973 | |
| Rhoj gtpase cycle 11 42 -0.260549809591741 0.7944396990978837 | |
| Hdr through single strand annealing ssa 13 29 -0.2578132900586048 0.796551007155617 | |
| Trna modification in the mitochondrion 5 9 0.2561982749182823 0.7977977406060415 | |
| Synthesis of pips at the er membrane 2 5 -0.2545756666168922 0.7990508553028222 | |
| Signal regulatory protein family interactions 4 5 0.2532675831264784 0.8000614445425989 | |
| Sumoylation of transcription factors 7 8 0.2530628327107102 0.800219659419237 | |
| Beta oxidation of pristanoyl coa 1 6 0.2528583233184053 0.8003776962356695 | |
| Metabolism of vitamins and cofactors 32 86 -0.2512415628075342 0.8016273523701083 | |
| Galactose catabolism 1 4 0.2471501124456182 0.8047920522592229 | |
| Mitochondrial biogenesis 13 53 -0.2456817813099495 0.8059285764251527 | |
| Syndecan interactions 1 8 0.2397550158782497 0.8105201820179635 | |
| Triglyceride catabolism 3 11 -0.2363651936093297 0.8131493025214394 | |
| Loss of mecp2 binding ability to the ncor smrt complex 2 4 -0.2344721282023338 0.8146184686157174 | |
| Met activates ptk2 signaling 3 7 -0.233398717030421 0.8154518093294707 | |
| Stat3 nuclear events downstream of alk signaling 2 6 -0.2301278603076142 0.8179924164082799 | |
| Adenylate cyclase inhibitory pathway 1 4 -0.2300945995354376 0.818018261268445 | |
| Irs mediated signalling 6 7 0.2294616914482627 0.8185100921118411 | |
| Release of apoptotic factors from the mitochondria 4 4 -0.2294345697830458 0.8185311698682964 | |
| Activated ntrk2 signals through frs2 and frs3 1 3 0.2289585463074591 0.8189011355609475 | |
| Frs mediated fgfr4 signaling 1 3 0.2289585463074591 0.8189011355609475 | |
| Frs mediated fgfr3 signaling 1 3 0.2289585463074591 0.8189011355609475 | |
| Frs mediated fgfr2 signaling 1 3 0.2289585463074591 0.8189011355609475 | |
| Frs mediated fgfr1 signaling 1 3 0.2289585463074591 0.8189011355609475 | |
| Lipophagy 2 6 -0.2264439797420633 0.8208561252394011 | |
| Budding and maturation of hiv virion 17 19 -0.2248405076937031 0.8221033521844494 | |
| Tie2 signaling 2 5 -0.2194400588815676 0.8263072678944647 | |
| Mtorc1 mediated signalling 4 16 -0.2152510335051944 0.8295716043329688 | |
| Prevention of phagosomal lysosomal fusion 3 5 0.2144908167424151 0.8301643275110497 | |
| Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 4 9 -0.2107634771981926 0.8330718393087435 | |
| Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 1 3 0.2074809711445648 0.8356342521664089 | |
| Glycogen storage diseases 4 5 0.2066146264987693 0.8363108364487195 | |
| Mitochondrial iron sulfur cluster biogenesis 6 6 -0.2037215447325009 0.8385711049920166 | |
| Type i hemidesmosome assembly 2 3 0.1995501661109187 0.8418324054475976 | |
| Vitamin b5 pantothenate metabolism 4 10 -0.1971380039532527 0.8437195440833829 | |
| Peroxisomal lipid metabolism 5 20 -0.1958935608208608 0.8446934773480979 | |
| Pyrimidine salvage 3 4 0.1952471315850576 0.845199483327032 | |
| Triglyceride metabolism 3 12 -0.1899283236356405 0.8493652973679118 | |
| Activation of irf3 irf7 mediated by tbk1 ikk epsilon 3 3 -0.1887115436882393 0.8503189035987087 | |
| Semaphorin interactions 6 33 -0.1829643242073025 0.854826011206324 | |
| Regulation of pten localization 1 4 -0.1828585376056064 0.8549090164866782 | |
| Negative regulation of the pi3k akt network 10 25 -0.181926208909131 0.8556406359753312 | |
| Rnd1 gtpase cycle 9 27 -0.1798218458875618 0.8572924326359737 | |
| Dissolution of fibrin clot 1 4 -0.1763722154292912 0.8600015313530414 | |
| Activation of ppargc1a pgc 1alpha by phosphorylation 4 4 -0.1758338906521222 0.8604244435334092 | |
| Signaling by mras complex mutants 3 6 -0.1755867610424918 0.8606186039136747 | |
| Synthesis of leukotrienes lt and eoxins ex 3 4 0.1737936371921071 0.8620276450829343 | |
| O linked glycosylation of mucins 2 7 -0.1731000255292557 0.8625728048850285 | |
| Regulation of ifng signaling 3 7 -0.172198260054667 0.8632816657254989 | |
| Foxo mediated transcription of oxidative stress metabolic and neuronal genes 4 8 -0.1709946154166707 0.8642279995162694 | |
| Sema3a pak dependent axon repulsion 2 11 -0.1693376545307538 0.865531059604441 | |
| Receptor mediated mitophagy 4 7 -0.166736292454751 0.8675775479955241 | |
| Loss of function of mecp2 in rett syndrome 9 9 -0.1574581167462766 0.8748838140764319 | |
| Class a 1 rhodopsin like receptors 4 11 -0.1517199280111247 0.8794078388507636 | |
| Peptide ligand binding receptors 4 11 -0.1517199280111247 0.8794078388507636 | |
| Regulation of ifna signaling 2 5 -0.1511341009655099 0.8798699327728763 | |
| Sema4d in semaphorin signaling 3 13 -0.1509746347467514 0.8799957250610952 | |
| Transcriptional regulation by mecp2 8 27 -0.148327877480363 0.8820840156482148 | |
| Synthesis of pips at the golgi membrane 2 12 -0.1475526894664593 0.8826957946185188 | |
| Egfr downregulation 3 13 -0.1462587819964284 0.88371710308768 | |
| Prc2 methylates histones and dna 2 12 -0.1435712784899653 0.8858390220876624 | |
| Diseases associated with glycosylation precursor biosynthesis 6 14 -0.1428482606469696 0.8864100214014794 | |
| Mitochondrial fatty acid beta oxidation 10 27 -0.1424287397940368 0.886741362715072 | |
| Interleukin 35 signalling 2 5 -0.1423656968386783 0.8867911563164026 | |
| Interleukin 27 signaling 2 5 -0.1423656968386783 0.8867911563164026 | |
| Pregnenolone biosynthesis 1 6 -0.1414988070912544 0.8874759023650982 | |
| Formation of incision complex in gg ner 6 26 -0.140809263724213 0.8880206245916595 | |
| Meiotic recombination 5 20 -0.1381572307965728 0.8901161557559323 | |
| Zbp1 dai mediated induction of type i ifns 5 10 -0.1370366030712281 0.8910018629511873 | |
| Signaling by ntrk2 trkb 4 9 -0.1362823333801871 0.8915980894959152 | |
| Acyl chain remodelling of pg 1 3 -0.1360719898937883 0.8917643703714655 | |
| Neurotransmitter release cycle 3 11 -0.1277901686679081 0.8983150305385224 | |
| Runx1 interacts with co factors whose precise effect on runx1 targets is not known 6 25 -0.1273552226857247 0.8986592547035777 | |
| Mapk3 erk1 activation 2 6 -0.1248006935591137 0.9006813383053385 | |
| Caspase activation via death receptors in the presence of ligand 1 5 -0.1219366255519725 0.9029492090469732 | |
| Regulation by c flip 1 5 -0.1219366255519725 0.9029492090469732 | |
| Synthesis of udp n acetyl glucosamine 1 6 -0.1199913500023372 0.904490000148201 | |
| Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 14 14 -0.119326526759141 0.9050166683246664 | |
| Amino acids regulate mtorc1 7 23 -0.1162986999327237 0.9074158159254546 | |
| Gp1b ix v activation signalling 1 4 -0.116044883412355 0.9076169702399588 | |
| Polo like kinase mediated events 9 9 -0.112363236585972 0.9105354036401884 | |
| Tnfr1 induced nfkappab signaling pathway 7 12 -0.1114458990474837 0.9112627645496802 | |
| Gaba synthesis release reuptake and degradation 1 4 -0.1091742491861196 0.9130642843774426 | |
| P75ntr negatively regulates cell cycle via sc1 1 3 -0.1086687857766698 0.9134652005419266 | |
| Rna polymerase iii transcription initiation from type 3 promoter 11 12 -0.0966622552578059 0.9229946153568482 | |
| Downstream signaling of activated fgfr3 2 5 -0.0931950288296368 0.9257486236222444 | |
| Downstream signaling of activated fgfr4 2 5 -0.0931950288296368 0.9257486236222444 | |
| Downstream signaling of activated fgfr1 2 5 -0.0931950288296368 0.9257486236222444 | |
| Downstream signaling of activated fgfr2 2 5 -0.0931950288296368 0.9257486236222444 | |
| Non integrin membrane ecm interactions 6 12 -0.0910987946708697 0.927414090375336 | |
| Rnd3 gtpase cycle 9 28 -0.0887452360059471 0.9292843812041784 | |
| Pre notch processing in golgi 3 8 -0.0878986875896298 0.929957199720175 | |
| Fanconi anemia pathway 8 14 -0.0718366493202586 0.9427319062111564 | |
| Sema4d mediated inhibition of cell attachment and migration 4 4 -0.0700579219847749 0.9441475577633625 | |
| Dex h box helicases activate type i ifn and inflammatory cytokines production 2 5 -0.069530535090068 0.9445673279737364 | |
| Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 2 4 -0.0552712262225341 0.9559223852617365 | |
| Translation of sars cov 2 structural proteins 7 26 -0.0523942077504205 0.958214589325457 | |
| Adp signalling through p2y purinoceptor 12 2 8 -0.0490549058871379 0.9608755400010104 | |
| Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 19 22 -0.0460309630597403 0.9632855711052736 | |
| Nuclear signaling by erbb4 4 8 -0.041501983208406 0.9668957118462608 | |
| Rhov gtpase cycle 9 28 -0.0404942771467637 0.9676990694764184 | |
| Egr2 and sox10 mediated initiation of schwann cell myelination 3 12 -0.0391870482515251 0.9687412597038916 | |
| Synthesis of bile acids and bile salts 2 12 -0.0307242984110861 0.9754894129778716 | |
| Bile acid and bile salt metabolism 2 12 -0.0307242984110861 0.9754894129778716 | |
| Tp53 regulates metabolic genes 13 59 -0.0300072941598482 0.976061235893249 | |
| Signalling to erks 6 17 -0.0262351661029867 0.9790697670344026 | |
| Regulation of tp53 activity through phosphorylation 22 58 -0.0120409308155939 0.9903929593496572 | |
| Class i peroxisomal membrane protein import 2 16 -0.0081281181580793 0.993514771422547 | |
| Synthesis of pc 5 10 -0.0059937070837155 0.9952177422893348 | |
| Noncanonical activation of notch3 3 3 -0.0011248959590767 0.9991024630710325 | |
| Aflatoxin activation and detoxification 3 6 -0.0002700514051645 0.999784530155815 | |
| Membrane trafficking 51 405 0.0 1.0 | |
| Assembly of collagen fibrils and other multimeric structures 3 5 0.0 1.0 | |
| Wnt mediated activation of dvl 1 5 0.0 1.0 | |
| Role of phospholipids in phagocytosis 2 7 0.0 1.0 | |
| Generation of second messenger molecules 8 8 0.0 1.0 | |
| Intracellular signaling by second messengers 30 141 0.0 1.0 | |
| Vitamin d calciferol metabolism 2 6 0.0 1.0 | |
| Hemostasis 43 200 0.0 1.0 | |
| Intrinsic pathway for apoptosis 13 35 0.0 1.0 | |
| Recognition and association of dna glycosylase with site containing an affected purine 1 6 0.0 1.0 | |
| Raf independent mapk1 3 activation 1 9 0.0 1.0 | |
| E2f mediated regulation of dna replication 4 17 0.0 1.0 | |
| Activation of bh3 only proteins 4 17 0.0 1.0 | |
| Transcription of e2f targets under negative control by dream complex 5 8 0.0 1.0 | |
| Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 4 6 0.0 1.0 | |
| Extracellular matrix organization 14 50 0.0 1.0 | |
| Synthesis of pg 1 5 0.0 1.0 | |
| Glycerophospholipid biosynthesis 15 51 0.0 1.0 | |
| Gamma carboxylation hypusine formation and arylsulfatase activation 2 15 0.0 1.0 | |
| Sphingolipid de novo biosynthesis 3 18 0.0 1.0 | |
| Signaling by ntrks 11 51 0.0 1.0 | |
| Transcription of the hiv genome 19 50 0.0 1.0 | |
| Signaling by flt3 fusion proteins 3 8 0.0 1.0 | |
| Activation of atr in response to replication stress 8 34 0.0 1.0 | |
| Darpp 32 events 2 13 0.0 1.0 | |
| Gab1 signalosome 3 6 0.0 1.0 | |
| Rnd2 gtpase cycle 7 27 0.0 1.0 | |
| Rip mediated nfkb activation via zbp1 4 9 0.0 1.0 | |
| Cytosolic sensors of pathogen associated dna 14 34 0.0 1.0 | |
| Signaling by cytosolic fgfr1 fusion mutants 2 12 0.0 1.0 | |
| Fgfr1 mutant receptor activation 13 14 0.0 1.0 | |
| Translation of sars cov 1 structural proteins 3 11 0.0 1.0 | |
| Metabolism of water soluble vitamins and cofactors 22 64 0.0 1.0 | |
| Integrin cell surface interactions 3 8 0.0 1.0 | |
| Synthesis secretion and deacylation of ghrelin 1 4 0.0 1.0 | |
| Signaling by type 1 insulin like growth factor 1 receptor igf1r 4 10 0.0 1.0 | |
| Rna polymerase i transcription 6 40 0.0 1.0 | |
| Rna polymerase ii transcription 101 520 0.0 1.0 | |
| Rna polymerase iii chain elongation 10 11 0.0 1.0 | |
| Rna polymerase i promoter escape 5 24 0.0 1.0 | |
| Rna polymerase i transcription initiation 32 34 0.0 1.0 | |
| Cyclin d associated events in g1 4 17 0.0 1.0 | |
| Chromosome maintenance 13 75 0.0 1.0 | |
| Mitotic prometaphase 31 153 0.0 1.0 | |
| Protein protein interactions at synapses 4 22 0.0 1.0 | |
| Neurexins and neuroligins 3 13 0.0 1.0 | |
| Peroxisomal protein import 7 36 0.0 1.0 | |
| Processing of dna double strand break ends 12 48 0.0 1.0 | |
| Nonhomologous end joining nhej 9 29 0.0 1.0 | |
| Homology directed repair 17 70 0.0 1.0 | |
| Signaling by moderate kinase activity braf mutants 8 22 0.0 1.0 | |
| Dna repair 47 186 0.0 1.0 | |
| Base excision repair ap site formation 1 8 0.0 1.0 | |
| Rna polymerase iii transcription termination 10 12 0.0 1.0 | |
| Metabolism of cofactors 6 11 0.0 1.0 | |
| Rac2 gtpase cycle 9 57 0.0 1.0 | |
| Plasma lipoprotein clearance 4 20 0.0 1.0 | |
| Rhou gtpase cycle 9 30 0.0 1.0 | |
| Inlb mediated entry of listeria monocytogenes into host cell 1 9 0.0 1.0 | |
| E3 ubiquitin ligases ubiquitinate target proteins 8 26 0.0 1.0 | |
| Cargo recognition for clathrin mediated endocytosis 11 57 0.0 1.0 | |
| Aurka activation by tpx2 11 54 0.0 1.0 | |
| Transcriptional regulation by ventx 5 22 0.0 1.0 | |
| Met activates ras signaling 2 6 0.0 1.0 | |
| Signaling by ptk6 8 22 0.0 1.0 | |
| Rna polymerase iii transcription initiation from type 1 promoter 18 18 0.0 1.0 | |
| Platelet activation signaling and aggregation 9 93 0.0 1.0 | |
| Insulin receptor signalling cascade 3 11 0.0 1.0 | |
| Rna polymerase iii transcription 5 20 0.0 1.0 | |
| Hdr through homologous recombination hrr 17 44 0.0 1.0 | |
| Raf activation 9 21 0.0 1.0 | |
| Rho gtpases activate formins 13 101 0.0 1.0 | |
| Signaling by fgfr1 in disease 15 16 0.0 1.0 | |
| Epha mediated growth cone collapse 4 14 0.0 1.0 | |
| Signal amplification 13 14 0.0 1.0 | |
| Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 1 6 0.0 1.0 | |
| Striated muscle contraction 3 9 0.0 1.0 | |
| Post chaperonin tubulin folding pathway 2 14 0.0 1.0 | |
| Ctla4 inhibitory signaling 5 13 0.0 1.0 | |
| Cd28 co stimulation 6 16 0.0 1.0 | |
| Deactivation of the beta catenin transactivating complex 16 16 0.0 1.0 | |
| Diseases of programmed cell death 5 39 0.0 1.0 | |
| Nephrin family interactions 6 14 0.0 1.0 | |
| Hdacs deacetylate histones 9 24 0.0 1.0 | |
| Regulation of innate immune responses to cytosolic dna 3 6 0.0 1.0 | |
| Insulin processing 5 18 0.0 1.0 | |
| The phototransduction cascade 1 8 0.0 1.0 | |
| Selective autophagy 12 52 0.0 1.0 | |
| Signaling by receptor tyrosine kinases 35 187 0.0 1.0 | |
| Constitutive signaling by aberrant pi3k in cancer 9 10 0.0 1.0 | |
| Activation of rac1 9 9 0.0 1.0 | |
| Role of abl in robo slit signaling 2 6 0.0 1.0 | |
| Signaling by fgfr4 in disease 1 3 0.0 1.0 | |
| Signaling by fgfr4 4 11 0.0 1.0 | |
| Signaling by fgfr3 4 11 0.0 1.0 | |
| Signaling by fgfr1 4 11 0.0 1.0 | |
| Traf6 mediated nf kb activation 7 12 0.0 1.0 | |
| Negative regulators of ddx58 ifih1 signaling 6 13 0.0 1.0 | |
| Vesicle mediated transport 51 413 0.0 1.0 | |
| Rho gtpases activate iqgaps 2 17 0.0 1.0 | |
| Pyroptosis 1 13 0.0 1.0 | |
| Metabolism of lipids 99 320 0.0 1.0 | |
| Negative epigenetic regulation of rrna expression 8 40 0.0 1.0 | |
| Synthesis of gdp mannose 1 4 0.0 1.0 | |
| Asparagine n linked glycosylation 36 188 0.0 1.0 | |
| Signal transduction by l1 15 16 0.0 1.0 | |
| Lysosome vesicle biogenesis 6 24 0.0 1.0 | |
| Inactivation of cdc42 and rac1 2 5 0.0 1.0 | |
| Ion channel transport 13 46 0.0 1.0 | |