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"protocol_version": 1,
"frozen_on": "2026-07-20",
"purpose": "Prospective temporal and homology-cold absolute enzyme kinetics benchmark",
"development_corpus": {
"name": "UniKP/DLKcat kcat development corpus",
"sha256": "13643b0b36374f8d3f64d8b014882cf1b3b58946eeaae2b9dcd59e8b2c2d6719",
"size_bytes": 12132719,
"rows": 17010,
"record_level_citations_available": false
},
"temporal_gate": {
"primary_measurement_article_published_on_or_after": "2023-01-01",
"deposit_date_alone_is_not_sufficient": true,
"preprints_require_a_stable_doi_and_explicit_dataset_license": true
},
"license_gate": {
"accepted": [
"CC0-1.0",
"CC-BY-4.0"
],
"deposit_license_must_cover_the_measurement_table": true,
"third_party_database_compilations_require_source_level_redistribution_rights": true
},
"record_inclusion": {
"direct_experimental_measurement": true,
"accepted_endpoints": [
"kcat_s-1",
"km_molar",
"kcat_per_km_M-1_s-1"
],
"primary_endpoint": "log10_kcat_s-1",
"full_protein_sequence_or_unambiguous_accession_and_variant": true,
"single_defined_substrate_with_structure_identifier": true,
"required_provenance": [
"measurement_article_doi",
"dataset_doi_or_stable_record_url",
"source_file",
"source_row_or_table_cell",
"organism",
"enzyme_identity",
"substrate_name",
"endpoint",
"value",
"unit",
"assay_temperature_if_reported",
"assay_pH_if_reported"
],
"derived_kcat_requires_enzyme_concentration_and_documented_formula": true,
"model_predictions_pseudolabels_and_relative_activity_are_excluded": true,
"bulk_environmental_or_community_apparent_kinetics_are_excluded": true
},
"leakage_gates": {
"exact_sequence_substrate_overlap_with_development": 0,
"mmseqs_min_identity": 0.3,
"mmseqs_coverage": 0.8,
"mmseqs_coverage_mode": 0,
"exclude_all_sequences_with_development_hit": true,
"publication_overlap": "exclude_when_known; report unavailable when development citations are absent",
"substrate_exact_and_murcko_scaffold_overlap": "report_and_stratify"
},
"diversity_and_size_gate": {
"minimum_records": 300,
"minimum_mmseqs_families": 30,
"minimum_unique_substrates": 50,
"maximum_records_per_family": 20,
"minimum_records_per_reported_family_metric": 3
},
"freeze_policy": {
"candidate_metadata_and_homology_may_be_audited_before_freeze": true,
"model_predictions_are_prohibited_before_final_selection_freeze": true,
"labels_may_not_drive_record_caps_or_family_selection": true,
"primary_model_checkpoint_and_metrics_must_be_frozen_before_evaluation": true,
"one_final_evaluation_only": true,
"failed_readiness_gate_means_no_model_evaluation": true
},
"planned_comparators": [
"train_mean",
"morgan_mlp",
"late_concat",
"task_query",
"DLKcat_when_training_overlap_is_reported_as_unavailable"
],
"claim_boundary": "Until every readiness gate passes, collected records are a curation pool and not an external benchmark. No model may be selected or tuned from this pool."
}
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