title stringlengths 3 364 | abstract stringlengths 36 3.48k | claims stringlengths 67 94.4k | main_ipcr_label stringclasses 500
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METHODS AND COMPOSITIONS FOR TARGETED MUTAGENESIS IN BACTERIA | This disclosure provides methods and compositions for targeted mutagenesis of specific genes in a bacterial strain. By inducibly over-expressing error-prone polymerases such as Pol IV or Pol V in conjunction with nickase in a bacterial strain, and housing the targeted gene(s) on an episome or plasmid which contains one... | 1. A method of generating mutations within a target DNA comprising: providing a host bacterial strain, which comprises a nucleic acid coding for an error-prone DNA polymerase under control of an inducible transcriptional regulatory region, a nucleic acid coding for a nicking enzyme, and a plasmid vector comprising said... | C12N | 20120914 | 2,012 | 2012:175871 |
Compositions, Kits and Methods for Synthesis and/or Detection of Nucleic Acids | A composition comprising a thermostable DNA polymerase; and a PCR inhibitor blocking agent, wherein the PCR inhibitor blocking agent is present in an amount effective to enhance tolerance of an assembled PCR to a PCR inhibitor. | 1. A polymerase chain reaction (PCR) composition, comprising: a thermostable DNA polymerase; and a PCR inhibitor blocking agent, wherein the PCR inhibitor blocking agent is present in an amount effective to enhance tolerance of an assembled PCR to a PCR inhibitor. 2. The composition of claim 1, wherein the PCR inhibito... | C12N | 20110621 | 2,011 | 2011:104669 |
GENES THAT INCREASE PLANT OIL AND METHOD FOR USING THE SAME | This invention is intended to be used to search for a transcription factor having novel functions of increasing the weight of an individual plant, increasing the weight of a given tissue per individual plant, or improving the productivity of a given substance per individual plant and to improve such properties in the p... | 1. A plant which expresses a chimeric protein, said chimeric protein comprising a transcription factor fused to a repressor domain sequence that converts said transcription factor into a transcription repressor, wherein said transcription factor is selected from the group consisting of (a) and (b): (a) a protein compri... | C12N | 20140321 | 2,014 | 2014:48947 |
REGULATORY SEQUENCES TO CONTROL GENE EXPRESSION IN PLANTS | The present invention discloses regulatory sequences, promoters and terminators, and their use in plants. The regulatory sequences can be used to make gene constructs that include a gene not natively associated with the regulatory sequences. Methods to use the regulatory sequences with antisense constructs or functiona... | 1. A nucleic acid construct comprising a nucleic acid having promoter activity in a plant operably linked to a heterologous DNA of interest, wherein the nucleic acid having promoter activity in a plant is selected from the group consisting of: (a) a nucleic acid comprising nucleotides 1-1493 of SEQ ID NO:1; (b) a nucle... | C12N | 20131029 | 2,013 | 2013:226358 |
GLUCOAMYLASE VARIANTS | The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (SBD) of a glucoamylase. The invention also relates to variants having altered properties (e.g., improved thermostability and/or increased specific activity) as compared to a correspondi... | 1-22. (canceled) 23. An isolated glucoamylase variant comprising a catalytic domain and a starch binding domain (SBD), a) said catalytic domain comprising at least 85% sequence identity to the amino acid sequence of SEQ ID NO:3 and b) said SBD comprising one or more amino acid substitutions at a position corresponding ... | C12N | 20130830 | 2,013 | 2013:168809 |
A Soluble and Stable Human 5-Lipoxygenase | A soluble and stable form of 5-lipoxygenase (5-LOX) has been made, 5-Lox is the enzyme which initiates leukotriene biosynthesis by catalyzing the two-step transformation of arachidomc acid to leukotriene A4 (LTA4). The soluble and stable 5-LOX is suitable for a number of applications, including, but not limited to, hig... | 1. An isolated 5-Lipoxygenase polypeptide comprising an amino acid sequence, numbered from the N-terminus, as set forth in SEQ ID NO:1 with one or more of the following modifications selected from the group comprising the following: (a) a replacement of amino acids Tryptophan and Phenylalanine at about residues 13-14 w... | C12N | 20130227 | 2,013 | 2013:2725 |
GENERAL COMPOSITION FRAMEWORK FOR LIGAND-CONTROLLED RNA REGULATORY SYSTEMS | The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of... | 1-21. (canceled) 22. A method for regulating expression of a recombinant gene, comprising: (i) providing a cell of claim 21, (ii) contacting the cell with said molecule in an amount that alters the activity of said modular actuator domain. 23-25. (canceled) 26. A method for rendering expression of a target gene in a ce... | C12N | 20120815 | 2,012 | 2012:146089 |
METHODS FOR MANUFACTURING PLANT CELL WALLS COMPRISING CHITIN | Methods and means are provided for the modification of the reactivity of plant secondary cell walls, particularly in cotton cell walls found in cotton fibers. This can be conveniently achieved by expressing a chimeric gene encoding a Saprolegnia monoica chitin synthase in cotton plants. | 1. An isolated nucleic acid molecule comprising a nucleotide sequence which encodes a chitin synthase polypeptide wherein said nucleotide sequence is at least 97% identical to SEQ ID NO: 1 or a complementary sequence thereof. 2. An isolated nucleic acid molecule comprising a nucleotide sequence which encodes a chitin s... | C12N | 20121109 | 2,012 | 2012:107848 |
REGULATING ALKALOIDS | MPO1 and MPO2 can be regulated for either decreasing or increasing alkaloid levels in plants, in particular in Nicotiana plants. In particular, suppressing or overexpressing one or more of MPO1 and MPO2 may be used to decrease or increase nicotine and nicotinic alkaloid levels in tobacco plants. Suppression or overexpr... | 1.-16. (canceled) 17. An N-methylputrescine oxidase-1 (MPO1) polypeptide having the amino acid sequence of SEQ ID NO: 2 18. An N-methylputrescine oxidase-2 (MPO2) polypeptide having the amino acid sequence of SEQ ID NO: 4 19. (canceled) 20. A method of producing an N-methylputrescine oxidase (MPO) enzyme, comprising: (... | C12N | 20150810 | 2,015 | 2015:136437 |
Interleukin-1 Alpha Antibodies and Methods of Use | Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors. | 1. A method of inhibiting migration of a cell through a basement membrane matrix, the method comprising the step of adding a purified mAb that specifically binds to human IL-1a to a mixture comprising the basement membrane matrix and the cell. 2. The method of claim 1, wherein the purified mAb is a human IgG1 mAb compr... | C12N | 20110902 | 2,011 | 2011:139120 |
HYDROXYNITRILE LYASE | An improved hydroxynitrile lyase characterized by having a mutation of substitution of at least one amino acid residue in the amino acid sequence of a wild-type hydroxynitrile lyase with another amino acid and by its hydroxynitrile lyase activity per transformant being higher than the hydroxynitrile lyase activity per ... | 1-12. (canceled) 13. An isolated or purified modified hydroxynitrile lyase that is at least 90% homologous to the wild-type hydroxynitrile lyase of Manihot escuela of SEQ ID NO: 1 or at least 90% homologous to the wild-type hydroxynitrile lyase of Hevea brasiliensis of SEQ ID NO: 102, and that has a substitution of at ... | C12N | 20110816 | 2,011 | 2011:130206 |
DNA PROMOTERS AND ANTRHAX VACCINES | The invention is related to intracellularly induced bacterial DNA promoters and vaccines against Bacillus anthracis. | 1. An attenuated bacterium for the expression of a heterologous protein, the expression of the heterologous protein being under the control of a promoter, wherein the promoter is selected from the group consisting of the promoters of SEQ ID NOs: 1-8 and functional fractions thereof. 2. The attenuated bacterium of claim... | C12N | 20120717 | 2,012 | 2012:125306 |
NUCLEIC ACID/POLYSACCHARIDE COMPLEX | An object of the present invention is to provide a highly stable nucleic acid-polysaccharide complex of an siRNA and schizophyllan. A nucleic acid-polysaccharide complex is formed by adding polydeoxyadenine in which at least part of the phosphodiester link portion is phosphorothioated to an siRNA and allowing the siRNA... | 1. A pharmaceutical preparation for suppressing rejection occurring in transplantation therapy, comprising a nucleic acid-polysaccharide complex of schizophyllan and a polynucleotide containing an siRNA to which polydeoxyadenine is added, against a costimulatory factor. 2. The pharmaceutical preparation according to cl... | C12N | 20131028 | 2,013 | 2013:160674 |
PON POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME AND COMPOSITIONS AND METHODS UTILIZING SAME | Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes. | 1. An isolated polypeptide comprising an amino acid sequence of a mutated serum paraoxonase (PON1) enzyme at least 95% identical to SEQ ID NO: 56, said mutated PON1 enzyme being characterized by: (i) a phosphotriester hydrolytic activity and phosphotriesterase substrate specificity; and (ii) no substantial formation of... | C12N | 20131021 | 2,013 | 2013:193744 |
DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION | Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells... | 1. A DNA polymerase having increased 3′-mismatch discrimination activity compared with a control DNA polymerase, wherein the amino acid of the DNA polymerase corresponding to position 752 of SEQ ID NO:1 is any amino acid other than N, and wherein the control DNA polymerase has the same amino acid sequence as the DNA po... | C12N | 20110711 | 2,011 | 2011:113516 |
Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same | The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 1-48. (canceled) 49. An isolated polypeptide having cellobiohydrolase activity, selected from the group consisting of: (a) a polypeptide having at least 68% sequence identity to the mature polypeptide of SEQ ID NO: 2, or a polypeptide having at least 68% sequence identity to the mature polypeptide of SEQ ID NO: 4, or a... | C12N | 20130624 | 2,013 | 2013:117096 |
MODULATION OF DYSTROPHIA MYOTONICA-PROTEIN KINASE (DMPK) EXPRESSION | Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compo... | 1. A method of treating an animal having type 1 myotonic dystrophy comprising administering to the animal a therapeutically effective amount of a compound comprising an oligonucleotide consisting of 10 to 30 linked nucleosides targeted to a DMPK nucleic acid, wherein the oligonucleotide has a nucleobase sequence that i... | C12N | 20150730 | 2,015 | 2015:132710 |
Hepatic Lobule-Like Bioreactor | The present invention provides a hepatic lobule-like bioreactor. The bioreactor includes a nanofiber scaffold enclosed within a housing. An intrahepatic fibrous vascular network, a bile capillary network, upper hepatic bile ducts, lower hepatic bile ducts, a common bile duct connecting the upper and the lower hepatic b... | 1. A hepatic lobule-like bioreactor, comprising: a closed-housing; a nanofiber scaffold enclosed within the housing; an intrahepatic fibrous vascular network where metabolism and material exchange take place, the intrahepatic fibrous vascular network provided with a liquid inlet port and a liquid outlet port; a bile ca... | C12N | 20131206 | 2,013 | 2013:163027 |
CELL CULTURING METHOD, CELL CULTURING APPARATUS AND KIT | The present invention relates to a cell culturing method as well as a cell culturing apparatus and kit for use in said culturing method. This cell culturing method comprises applying cells on a porous polyimide film and culturing. One embodiment of the method according to the present invention comprises a process for s... | 1. A cell culturing method that includes applying cells to a porous polyimide film and culturing them. 2. The method according to claim 1, including a step of seeding cells on the surface of a porous polyimide film. 3. The method according to claim 1, including a step of: placing a cell suspension on the dried surface ... | C12N | 20160125 | 2,016 | 2016:2178 |
METHODS FOR TREATING NIEMANN-PICK TYPE C DISEASE | The present invention includes methods for treating Niemann-Pick Type C disease through administration of inhibitors of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT inhibitors are used to treat symptoms of Niemann-Pick Type C disease and prolong survival of patients with the disease, either alone or in c... | 1. A method for treating Niemann-Pick Type C disease comprising administering to a patient diagnosed with Niemann-Pick Type C disease an effective amount of an Acyl-CoA:Cholesterol Acyltransferase (ACAT) inhibitor in a pharmaceutically acceptable vehicle. 2. The method of claim 1, wherein the ACAT inhibitor is administ... | C12N | 20140326 | 2,014 | 2014:56806 |
Manufacturing Method of Immune Killer Cells | The present invention relates to a manufacturing method of immune killer cells characterized in that an immune killer cell is induced in a culture medium containing concanavalin A (ConA), and the immune killer cell is maintained or expanded in a culture procedure. Antibody proteins are not used as a stimulant in the cu... | 1. A manufacturing method of immune killer cells, comprising steps of having an immune killer cell is induced in a culture medium containing concanavalin A (ConA), and the immune killer cell is maintained or expanded a culture procedure. 2. The manufacturing method of immune killer cells according to claim 1, wherein t... | C12N | 20110209 | 2,011 | 2011:24047 |
Compositions and Methods for Reducing Background DNA Amplification | Compositions are provided that include a plurality of small molecules selected from the group consisting of an amide, urea or acetone having a molecular weight less than 300 g/mol; and dNTPs and a polymerase in a buffer suitable for use as an amplification buffer. Methods of use of the compositions are also described f... | 1. A composition comprising a plurality of small molecules selected from the group consisting of an amide, urea or acetone having a molecular weight less than 300 g/mol; and dNTPs and a polymerase in a buffer suitable for use as a DNA amplification buffer. 2. A composition according to claim 1 wherein the plurality of ... | C12N | 20130313 | 2,013 | 2013:44102 |
DOUBLE STRANDED RNA CONSTRUCTS FOR APHID CONTROL | Disclosed are specific aphid dsRNA constructs that target either Chloride Intracellular Channel (CLIC) gene expression or Sucrase gene expression. Also disclosed is the use of dsRNA constructs of a CLIC gene to interfere with critical functions of CLIC gene peptide products. A novel method to develop nucleic acid contr... | 1. A double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a chloride intracellular channel protein (CLIC) in a cell, wherein said dsRNA comprises a sense strand comprising a first sequence and an antisense stand comprising a second sequence complementary to SEQ ID NO: 5, wherein said first sequence... | C12N | 20150813 | 2,015 | 2015:138066 |
Oligomers | Certain disclosed oligomers induce exon skipping during processing of myostatin pre-mRNA. The oligomers may be in a vector or encoded by the vector. The vector is used for inducing exon skipping during processing of myostatin pre-mRNA. A therapeutically effective amount of the oligomer may be administered to a subject ... | 1. An oligomer for inducing exon skipping during processing of myostatin pre-mRNA, the oligomer comprising at least 20 contiguous bases of a base sequence selected from the group consisting of: (SEQ ID NO. 1) 1) XCXCGACGGGXCXCAAAXAXAXCCAXAGXX; (SEQ ID NO. 2) 2) XGXACCGXCXXXCAXAGGXXXGAXGAGXCX; (SEQ ID NO. 3) 3) CCXGGGXX... | C12N | 20141002 | 2,014 | 2014:191168 |
BACULOVIRUS SYSTEM FOR THE EXPRESSION OF A GENE THERAPY VECTOR | The invention concerns a recombinant baculovirus genome useful for the expression of gene therapy vectors by means of a single infection. | 1. A recombinant baculovirus genome comprising one or more expression cassettes for the protein components required for the production of a heterologous viral vector, and a recombinant genome of a heterologous viral vector, said expression cassettes and said recombinant genome of a heterologous viral vector being inser... | C12N | 20140623 | 2,014 | 2014:56498 |
FLOW CYTOMETER METHOD AND APPARATUS | A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electro... | 1-80. (canceled) 81. A nozzle for use in flow cytometry apparatus for analyzing particles in a fluid stream, said fluid stream comprising a sheath stream surrounding a core stream containing said particles, said nozzle comprising: a nozzle having an interior surface defining a flow path for said fluid stream, and an or... | C12N | 20130301 | 2,013 | 2013:33907 |
METHOD FOR PRODUCING HEMATOPOIETIC STEM CELLS USING PYRAZOLE COMPOUNDS | An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided. A method of producing hematopoietic stem cells and/or hem... | 1: A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, the method comprising expanding hematopoietic stem cells and/or hematopoietic progenitor cells by culturing hematopoietic stem cells ex vivo in the presence of a pyrazole compound represented by the formula (1): wherein: R1 is a hy... | C12N | 20131104 | 2,013 | 2013:155351 |
METHODS FOR RAPIDLY TRANSFORMING MONOCOTS | The present invention provides methods for transforming monocot plants via a simple and rapid protocol, to obtain regenerated plants capable of being planted to soil in as little as 4-8 weeks. Associated cell culture media and growth conditions are also provided, as well as plants and plant parts obtained by the method... | 1. A method for producing a transgenic corn plant comprising: a) transforming an explant with at least a first selected DNA via bacterially mediated transformation of the explant; b) culturing the explant in a first culture medium comprising an effective ratio of cytokinin and auxin to promote development of regenerabl... | C12N | 20140911 | 2,014 | 2014:179662 |
MUTATED REP ENCODING SEQUENCES FOR USE IN AAV PRODUCTION | The invention relates to a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein, wherein a nuclear localization signal (NLS) in said Parvoviral Rep protein is mutated as compared with a corresponding wild type sequence. The invention also relates to a nucleic acid comprising a nucleotide sequ... | 1. A nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein, wherein a nuclear localization signal (NLS) in said Parvoviral Rep protein is mutated as compared with a corresponding wild type sequence. 2. The nucleic acid according to claim 1, wherein the NLS is at least partially truncated and/o... | C12N | 20120910 | 2,012 | 2012:144885 |
Stabilization Of Perhydrolases | Disclosed herein are enzyme powders comprising a spray-dried formulation of at least one CE-7 esterase, at least one oligosaccharide excipient, and optionally at least one surfactant. Also disclosed herein is a process for producing peroxycarboxylic acids from carboxylic acid esters using the aforementioned enzyme powd... | 1. A process to stabilize the perhydrolysis activity of an enzyme when present in a formulation comprised of said enzyme and a carboxylic acid ester, the process comprising: (a) providing an aqueous formulation comprising: (i) at least one enzyme structurally classified as a CE-7 enzyme and having perhydrolysis activit... | C12N | 20120712 | 2,012 | 2012:123089 |
METHOD OF ISOLATING NUCLEIC ACID FROM SPECIMENS IN LIQUID-BASED CYTOLOGY PRESERVATIVES CONTAINING FORMALDEHYDE | Method, composition, kit and system for isolating amplifiable nucleic acid from specimens preserved in a liquid-based cytology preservative that contains formaldehyde. The technique relies on the use of 2-imidazolidone and a protease enzyme, such as proteinase K, at elevated temperatures. Advantageously, RNA can be iso... | 1. A method of processing a specimen that includes a clinical sample disposed in a liquid-based cytology preservative that comprises formaldehyde, the method comprising the steps of: (a) combining the specimen with a protease enzyme and formaldehyde scavenger to create a reaction mixture; (b) incubating the reaction mi... | C12N | 20150302 | 2,015 | 2015:44188 |
CULTURE MEDIUM | A culture medium is used for culturing neural cells. Each neural cell includes a neural cell body and at least one neurite branched from the neural cell body. The culture medium includes a substrate and a carbon nanotube structure located on the substrate. The carbon nanotube structure includes a number of carbon nanot... | 1. A culture medium for culturing neural cells, each neural cell comprising a neural cell body and at least one neurite branched from the neural cell body, the culture medium comprising: a substrate; and a carbon nanotube structure located on the substrate, the carbon nanotube structure comprising a plurality of carbon... | C12N | 20120801 | 2,012 | 2012:133193 |
MESENCHYMAL-LIKE STEM CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS, METHODS AND USES THEREOF | The present invention relates to methods of generating and expanding hitman embryonic stem eel! derived mesenchymal-like stem/siromal cells. These hES-MSCs are characterized at least in part by the low level of expression of IL-6. These cells are useful for the prevention and treatment of T cell related autoimmune dise... | 1. A method for producing human embryonic stem cell-derived mesenchymal stem cells, comprising: a. culturing human embryonic stem cells with serum free media with or without GSK3 inhibitors; b. culturing human embryonic stem cells in serum-free media comprising vascular endothelial growth and bone morphogenic protein 4... | C12N | 20150107 | 2,015 | 2015:1476 |
SEPARATONE-BASED PROTEIN EXPRESSION AND PURIFICATION PLATFORM | Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome, s... | 1-91. (canceled) 92. A host cell for expression of a target recombinant peptide, polypeptide, or protein, wherein the chromatographic separation efficiency of said target recombinant peptide, polypeptide, or protein expressed in said host cell is improved in an amount in the range of from about 5% to about 35%, wherein... | C12N | 20141023 | 2,014 | 2014:200779 |
SHORT INTERFERING RIBONUCLEIC ACID (siRNA) FOR ORAL ADMINISTRATION | Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification. | 1. Short interfering ribonucleic acid (siRNA), comprising two strands that are complementary to each other over at least 15 nucleotides, wherein each strand comprises 49 nucleotides or less, and wherein the first two base-pairing nucleotides at the 3′ end of each strand are 2′-methoxyethyl ribonucleotide residues. 2. T... | C12N | 20140211 | 2,014 | 2014:24441 |
MODIFICATIONS OF PEPTIDE COMPOSITIONS TO INCREASE STABILITY AND DELIVERY EFFICIENCY | The disclosed invention relates to methods of modifying peptide compositions to increase stability and delivery efficiency. Specifically, the disclosed invention relates to methods to increase the stability and delivery efficiency of protein kinase C (PKC) modulatory peptide compositions. A “therapeutic peptide composi... | 1. A protein kinase C (PKC) modulatory peptide composition, comprising: a PKC modulatory peptide covalently linked to an intracellular carrier peptide, wherein the intracellular carrier peptide, the modulatory peptide, or both are modified at the N-terminus. 2. The composition of claim 1, wherein the PKC modulatory pep... | C12N | 20111128 | 2,011 | 2011:186569 |
METHOD FOR REGULATING ACID RESISTANCE OF MICROBES | Provided are a method for regulating acid resistance of a microorganism by suppressing the expression of the fadD gene therein and a screening method for a microorganism having acid resistance by using the expression level of the fadD gene as an index. A method for regulating acid resistance of a microorganism, includi... | 1: A method for regulating acid resistance of a microorganism, the method comprising controlling the expression of fadD gene present in the microorganism. 2: The method for regulating acid resistance according to claim 1, wherein the acid resistance is acid resistance which maintains a function in a low temperature sta... | C12N | 20160527 | 2,016 | 2016:24541 |
NOROVIRUS AND SAPOVIRUS ANTIGENS | Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such ... | 1. A multiple epitope fusion protein comprising two or more epitopes from more than one isolate of a Norovirus and/or a Sapovirus. 2. The multiple epitope fusion protein of claim 1, wherein the two or more epitopes are encoded by ORF1, ORF2 and/or ORF3 of a Norovirus and/or Sapovirus isolate. 3. The multiple epitope fu... | C12N | 20121127 | 2,012 | 2012:206278 |
IMMORTALIZED MESENCHYMAL STROMAL CELL FROM ADIPOSE TISSUE | The present invention relates to a composition for diagnosing a Parkinson's disease comprising mesenchymal stromal cells derived from adipose tissue, a method of providing information for diagnosing Parkinson's disease and/or the extent of the disease progression, a biomarker for diagnosing a Parkinson's disease, a met... | 1. An immortalized mesenchymal stromal cell, which is prepared by immortalizing a mesenchymal stromal cell separated from human adipose tissue using human telomerase reverse transcriptase. 2. The immortalized mesenchymal stromal cell of claim 1, which is prepared by immortalizing a mesenchymal stromal cell separated fr... | C12N | 20150223 | 2,015 | 2015:40512 |
APTAMER CAPABLE OF BINDING TO VIRAL HEMORRHAGIC SEPTICEMIA VIRUS | A pharmaceutical and a method for preventing and treating VHSV infection in fish with a VHSV-binding aptamer is provided. Also provided are a method for removing VHSV from an area of water and a method and kit for detecting VHSV with high sensitivity using a VHSV-binding aptamer. | 1. A viral hemorrhagic septicemia virus (VHSV)-binding aptamer having an activity of binding to a VHSV and/or a polypeptide expressed by the VHSV and suppressing the VHSV infection of a host. 2. The VHSV-binding aptamer according to claim 1, wherein the VHSV has a genotype of type I. 3. The VHSV-binding aptamer accordi... | C12N | 20120628 | 2,012 | 2012:96140 |
METHODS AND COMPOSITIONS FOR PRODUCING INDUCED AIRWAY TISSUE PROGENITOR CELLS | A method of generating an induced progenitor population (iPP) of cells and/or induced population of cells from somatic cells, comprising the steps: a) obtaining a starting cell population, wherein cells of the starting cell population comprise, or are contacted with, a nucleic acid molecule encoding four reprogramming ... | 1. A method of producing an induced progenitor population (iPP) or induced population of cells from airway tissue somatic cells, comprising the steps: a. obtaining a starting cell population of airway tissue somatic cells, the cells of the starting cell population comprising one or more exogenous reprogramming factors;... | C12N | 20140603 | 2,014 | 2014:90900 |
PHOTOSYNTHETIC RESOURCE USE EFFICIENCY IN PLANTS EXPRESSING REGULATORY PROTEINS | Polynucleotides and polypeptides incorporated into expression vectors are introduced into plants and were ectopically expressed. These polypeptides may confer at least one regulatory activity and increased photosynthetic resource use efficiency, increased yield, greater vigor, greater biomass as compared to a control p... | 1. A transgenic plant having greater photosynthetic resource use efficiency than a control plant; wherein the transgenic plant comprises one or more exogenous recombinant polynucleotides comprising a photosynthetic tissue-enhanced promoter and a nucleic acid sequence that encodes a polypeptide comprising any of SEQ ID ... | C12N | 20150203 | 2,015 | 2015:4863 |
FUSION PROTEINS OF COLLAGEN-BINDING DOMAIN AND PARATHYROID HORMONE | Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to prom... | 1-60. (canceled) 61. A method of attaining an outcome comprising administering to a mammal an effective amount of a composition comprising a ColH or ColG bacterial collagen-binding polypeptide segment linked to a PTH/PTHrP receptor agonist, wherein the PTH/PTHrP receptor agonist comprises residues 1-14 of SEQ ID NO: 1,... | C12N | 20130520 | 2,013 | 2013:101488 |
BGL6 BETA-GLUCOSIDASE AND NUCLEIC ACIDS ENCODING THE SAME | The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding BGL6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL6, recombinant BGL6 proteins and methods for producing the same. | 1.-17. (canceled) 18. A substantially purified BGL6 polypeptide with the biological activity of a β-glucosidase, comprising a sequence selected from the group consisting of: (a) an amino acid sequence having at least 85% sequence identity to the amino acid sequence presented in FIG. 2 (SEQ ID NO:2); (b) an amino acid s... | C12N | 20120425 | 2,012 | 2012:68306 |
CYTOCHROME P450 OXYGENASES | Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cyt... | 1-67. (canceled) 68. An isolated polypeptide having activity of a cytochrome P450 variant, wherein the variant is characterized as comprising a higher capability than the corresponding wild-type cytochrome P450 to oxidize at least one substrate selected from an alkane comprising a carbon-chain of no more than 8 carbons... | C12N | 20111212 | 2,011 | 2011:196385 |
PORTABLE NIPPLE BASED POULTRY WATERER | A portable poultry waterer is provided having a manifold with a connector placed on the back surface to attach the manifold to a water storage vessel. The connector extends outward in a substantially perpendicular fashion to the manifold. Holes are placed into the manifold to accept a plurality of longitudinally spaced... | 1. A portable nipple based poultry waterer, comprising: a manifold; a connector disposed on a back surface of the manifold and extending out in a direction substantially perpendicular to the back surface of the manifold; a first clean-out plug hole disposed on the manifold; a first nipple hole disposed on a lower surfa... | A01K | 20130312 | 2,013 | 2013:42856 |
Interchangeable Flow Directing Orifice Inserts And Recirculating Pet Fountain With Flow Directing Orifice Inserts | A recirculating pet fountain having a cover mounted on a basin in a manner that removably seats the cover on the basin. An inclined spillway of the cover has an intake-defining edge below water in the basin producing a spillway that also is a debris and detritus blocking barrier. The fountain includes at least one remo... | 1. A recirculating pet fountain comprising: a basin having a bottom and sidewall extending upwardly therefrom; a pump; and a cover removably carried by the basin. 2. The pet fountain of claim 1 further comprising one of a plurality of different interchangeable flow directing discharge orifice inserts. 3. The pet founta... | A01K | 20130909 | 2,013 | 2013:172177 |
Collapsible Wire Crate And Method Of Assembly | The present invention provides a wire crate for housing an animal. The wire crate includes a top panel, a bottom panel, a front panel, a back panel, and a pair of side panels oppositely disposed from one another. The crate also includes a front opening defined in the front panel. The front opening is configured to prov... | 1. A wire crate for housing an animal, comprising: a top panel, a bottom panel, a front panel, a back panel, and a pair of side panels oppositely disposed from one another; an opening defined in the front panel or one of the side panels, the opening configured to provide access to the interior of the crate; a plurality... | A01K | 20110923 | 2,011 | 2011:150053 |
Method of Establishing Mouse Strain | A method of producing a chimera animal, characterized by transplanting, into a host animal, an aggregate of a first pluripotent stem cell that is of interest to strain establishment, a second pluripotent stem cell in which the ability to form germ cells is absent or decreased, and embryo. | 1. A method for producing a chimeric animal, comprising the step of transferring an aggregate of a first pluripotent stem cell that is of interest to strain establishment, a second pluripotent stem cell associated with lack or low ability to form germ cells and an embryo into a host animal. 2. The method according to c... | A01K | 20130429 | 2,013 | 2013:54692 |
Animal Pen Door | An animal pen according to the invention comprises an access wall spanning the width of the pen between two side walls. An access door in the access wall is hinged to a vertical hanging post and closes against a vertical slam post. A first of the posts, which may be the hanging post or the slam post, is supported at it... | 1. An animal pen comprising an access wall spanning the width of the pen between two side walls, the access wall having an access door therein hinged to a vertical hanging post and closing against a vertical slam post, wherein a first of the posts is supported at its top end not by a door lintel extending between the h... | A01K | 20111222 | 2,011 | 2011:203313 |
Loader Mounted Blower for Cleaning Chicken Houses | A blower apparatus is supported on a frame detachably mounted on the implement mounting plate for a skid steer loader. The blower is powered by a hydraulic motor operatively connected to the auxiliary hydraulic system of the skid steer loader. The blower is mounted on the frame in a manner that orients the discharge sp... | 1. A blower apparatus comprising: a frame including a rear plate adapted to connection with a mounting plate on a prime mover and a support frame extending forwardly from said rear plate; a blower mounted on said frame, said blower being operatively powered by a hydraulic motor and having a discharge spout directing a ... | A01K | 20140624 | 2,014 | 2014:101229 |
AUTOMATIC FEEDING SYSTEM FOR UNDERWATER FISH FARM | Disclosed is an automatic feeding system for an underwater fish farm, which includes a marine base facility standing vertically in the sea; an underwater fish farm installed on an outer surface of the marine base facility; a storage tank installed inside the marine base facility to store feed to be supplied to the unde... | 1-26. (canceled) 27. An automatic feeding system for an underwater fish farm, comprising: a marine base facility standing vertically in the sea, in which a lower portion is fixed on the seabed and an upper portion is exposed above the sea surface; an underwater fish farm for cultivating various types of fish; a storage... | A01K | 20130715 | 2,013 | 2013:149308 |
LIGHTED FISHING FLOAT WITH IMPROVED LINE CLAMP | A fishing float with an improved line arrestor to releasably clamp the fishing float to the fishing line. The line arrestor includes a lock clamp and a slip clamp so that the line may be secured to the fishing line at a desired position, or alternatively may be secured to the fishing line yet allow the fishing float to... | 1. A fishing float comprising: a housing having top, a base, a tube extending downwardly from said base and having an open end; a cap removably engaged with said open end of said tube, said cap having lock tab and a slip tab; and a line arrestor received within said open end of said tube and secured by said cap, said l... | A01K | 20141223 | 2,014 | 2014:232513 |
FISHING LINE REEL WITH RAPID LINE PAYOUT | A reel for fishing line or the like provides for extremely rapid payout by releasing the line to unwind by sliding rapidly around a guide surrounding the line spool and by rotation of the line spool itself. A lever controls a line guide preventing sliding of the fishing line around the guide and providing controllable ... | 1. A fishing line reel providing rapid line payout comprising: a housing supporting: a crank mechanism operable by a user for rotating a first shaft extending along an axis with respect to the housing; a line spool rotatable about the first shaft; a winder attached to rotate with the first shaft and having a line guide... | A01K | 20140506 | 2,014 | 2014:77292 |
DUAL-BEARING REEL | A dual-bearing reel includes a reel unit, a handle, a spool shaft, a spool, and a casting control mechanism. The handle is rotatably supported by the reel unit. The spool shaft is rotatably supported at an end thereof by the shaft support part. The spool is mounted onto the spool shaft, where the spool is configured to... | 1. A dual-bearing reel, comprising: a reel unit including a frame, a first cover having a recess, the first cover covering a first side of the frame, a second cover covering a second side of the frame, and a shaft support part attached to the frame on a first cover side; a handle rotatably supported by the reel unit on... | A01K | 20120808 | 2,012 | 2012:136766 |
MILKING PARLOUR AND METHOD FOR OPERATING THE SAME | An apparatus for milking an animal and provides a milking parlour includes first and second robotic manipulation devices and a plurality of milking stalls provided on a platform moveable relative to the robotic manipulation devices. The robotic manipulation devices are positioned so that each of the robotic manipulatio... | 1. A milking parlour (1), comprising: a rotatable platform (3) comprised of plural milking stalls (5), each milking stall having a set of teat cups (23); a first robotic manipulation device with a first arm and a first rearward-facing sensing unit that senses in a rearward direction relative to the first arm; a second ... | A01K | 20140521 | 2,014 | 2014:84281 |
Non-Choking Dog Harness | A pet harness device is disclosed that enables users to control animals without placing unnecessary pressure or stress on the animal's trachea, neck, and/or leg pits. The pet harness device comprises an X-shaped component secured around an animal's front legs and chest and then secured on top of an animal's back via a ... | 1. A pet harness device for use with an animal, comprising: an X-shaped component comprising a top end, a bottom end, a first pair of extending portions, a second pair of extending portions, a front surface, and a back surface; a cord component comprising a first end and a second end, and that secures the first pair of... | A01K | 20140411 | 2,014 | 2014:65671 |
DOG TOY | A dog toy having a center portion and two opposedly positioned free ends. Each of the free ends of the elongated member includes a plurality of extension members [tines] having a first end connected to the elongated member and a free end spaced apart from the connected portion. The extension members are manufactured by... | 1. A dog toy used for purposes of play and retrieval, the dog toy comprising: an elongated member having a first end and a second end, an elongated portion extending between the first end and the second end, the elongated member further including a holding portion; and a plurality of tines positioned on at least one of... | A01K | 20130111 | 2,013 | 2013:7883 |
BAIT BRIDLE | A bait bridle is uniquely designed to connect a hook to bait while allowing the entire hook to be exposed for enhanced hooking capabilities and free movement of the bait. The addition of a small elastic band to the hook end of the bridle holds the hook firmly in place, yet allows easy removal when desired. The re-usabl... | 1. A bait bridle comprising: a loop section having a locking bend and a wire extending therefrom, the locking bend formed from a lock slot top wire and a lock slot bottom wire; a bait loop formed by the wire, where the end of the bait loop removably fits into the locking bend of the loop section; and an elastic band fi... | A01K | 20130709 | 2,013 | 2013:124866 |
APPARATUS FOR SUPPORTING A PET | A pet bed having a pet cushion for supporting a pet has a lower cushion for improving comfort when held on one's lap. Between the pet cushion and the lower cushion is an intermediate planar layer made of a stiff material. The pet cushion rests on or is affixed to a top surface of the intermediate planar layer and the t... | 1. A pet bed comprising: a pet cushion, the pet cushion having a pet surface and a bottom surface, the pet surface of the pet cushion providing a surface for supporting a pet; a lower cushion, the lower cushion having a top surface and a bottom surface, the bottom surface of the lower cushion providing a surface for su... | A01K | 20110822 | 2,011 | 2011:132454 |
KIT FOR ASSEMBLING AN AQUARIUM AQUAPONIC ASSEMBLY AND AQUARIUM AQUAPONIC ASSEMBLIES THEREOF | A kit for an aquarium aquaponic assembly is disclosed. The kit comprises generally an aquarium module, a garden module, a reservoir module, drain conduits fluidly connecting the modules and a pump. The reservoir module has a top opening adapted to receive and maintained both the aquarium module and at least one garden ... | 1) An kit for assembling an aquarium aquaponic assembly, the kit comprising: a reservoir module configured to receive water and having side walls extending from a bottom wall, the side walls having top ends defining a top opening; an aquarium module comprising a transparent tank adapted to hold water for housing aquati... | A01K | 20161223 | 2,016 | 2016:114524 |
SYSTEM FOR DEVELOPMENT OF THERAPEUTIC DRUGS AND PROCEDURES | The present invention relates to a device and method for delivering drugs or sending or receiving information to or from a lab test animal over a long period of time without having the cords attached to the animal tangle as it moves around in its enclosure. | 1. An animal test system for use with a moving tethered test animal comprising: a. an animal chamber having a bottom surface for containing the test animal; b. a rotating platform positioned above the animal chamber bottom; c. a motor for rotating the platform clockwise and counterclockwise; d. at least one connector f... | A01K | 20120824 | 2,012 | 2012:150860 |
Cinch Grip Leash with Locking Positionable Hand Grip | Provided is an animal leash with leash strap retractable through an ergonomic hand grip which is releasably fixed to said leash at any length position along the leash strap, and is quickly adjusted by simple push button release and manual repositioning. Leash is fixed against being pulled through handle in either direc... | 1. An animal control leash device comprising: a leash strap with an animal attachment end and an animal handler end; a grip handle with passageway through its body for the leash strap; a stop mechanism within said body which stops travel of the leash strap in both longitudinal directions until disengaged; and means for... | A01K | 20150915 | 2,015 | 2015:151778 |
ANIMAL HARNESS | A harness for restraining an animal, particularly a dog, includes: a body loop to encircle a rear abdominal area of the animal, wherein the body loop comprises a connector to a leash to be held by a person; and at least one rear-leg loop to encircle a top area of a rear leg of the animal; wherein the body loop comprise... | 1. A harness for restraining an animal, the harness comprising: a body loop to encircle a rear abdominal area of the animal, wherein the body loop comprises a connector to a leash to be held by a person; at least one rear-leg loop to encircle a top area of a rear leg of the animal, wherein the body loop comprises a las... | A01K | 20130403 | 2,013 | 2013:76050 |
Bird feeder | A bird feeder comprising a feed container having a side wall and a plurality of feed openings therein, a shroud extending about the feed container, the shroud having feed openings therein, the feed openings being spaced from the top of the shroud by a distance equal to between 20% and 80% of the total height thereof, a... | 1. A bird feeder comprising: a feed container having a side wall, a plurality of feed openings in said side wall; a shroud extending about said feed container, said shroud having feed openings therein, said feed openings being located between a bottom of said shroud and a top of said shroud, said feed openings being sp... | A01K | 20120829 | 2,012 | 2012:138702 |
Collapsible and Portable Pet Crate | Present invention provides a pet house or a pet crate that is easily collapsible, foldable and portable, having four side walls, connected to a roof plate, with a frame support built to the edges of the left and right side walls, when two first zippers zip up along the left and right side walls' edges to form the compl... | 1. A collapsible and portable pet crate, comprising: a generally rectangular base plate; a generally rectangular front side wall; a generally rectangular back side wall; a generally rectangular top plate; a left side wall and a right side wall, both walls are connected to the base plate at the bottom, said left side wa... | A01K | 20150519 | 2,015 | 2015:18464 |
FISHING POLE HOLDER AND ALERT SYSTEM FOR ICE FISHING | The present invention generally relates to fishing pole holder for ice fishing. Specifically, embodiments of the present invention provide a fishing rod holder with an alert system to notify a fisherman that a fish has been hooked. | 1. An indicator system for a fishing rod holder, the indicator system comprising: a flag assembly comprising, a flag staff with a first end attached to an indicator signal and a second end attached to a first end of a spring element, wherein said spring element is configured to move said flag staff between a first posi... | A01K | 20140623 | 2,014 | 2014:100833 |
REVERSIBLE FISH LURE AND METHOD OF MAKING | A reversible lure and method of making in which a cam lever from a nail clipper is removed and suitable hook and line are attached to opposing ends thereof. The elongate body has opposing first and second ends and a central section with the first end having an angled section extending from the central section, an openi... | 1. A device, comprising: an elongate body having a central section and opposing first and second ends, the body having a generally planar shape with mutually opposing parallel first and second sides, the first end having an angled section extending from the central section, the angled section having an opening formed t... | A01K | 20130717 | 2,013 | 2013:128681 |
PORTABLE SYSTEM FOR DISPENSING FLUIDS FOR ANIMALS | A portable dispensing device for administering fluids intended for animals comprising a backpack with a main compartment delimited by a rear wall configured to come into contact with the back of the user, an outer wall arranged opposite the rear wall and a side wall linking the rear and outer walls, in addition to a fl... | 1. A portable dispensing device for administering fluids intended for animals comprising: a backpack with a main compartment delimited by a back wall configured to be in contact with the back of a user, an outer wall laid out oppositely to the back wall and a side wall connecting the back and outer walls; and a flexibl... | A01K | 20160107 | 2,016 | 2016:690 |
ANIMAL LITTER HAVING LIGHT-WEIGHT COMPOSITION AND A PROPERTY OF DETECTING ANIMAL HEALTH CONDITIONS FROM CONTACT WITH ANIMAL URINE | Disclosed are compositions of matter and a method of manufacturing that may be used to create animal litter that detects health conditions with feline animals. For example, feline urine detection may be performed by color generation when a feline animal urinates on the litter composition. The color generation propertie... | 1. A composition of matter comprising: 70-90 percent by weight light weight aggregate; 7-10 percent by weight polymer; 1.0-2.0 percent by weight process water; and 8-10 percent by weight oil. 2. The composition of matter of claim 1, further comprising: 0.01-0.09 percent by weight color reagent. 3. The composition of ma... | A01K | 20130220 | 2,013 | 2013:27242 |
Pet Animal Collar for Health & Vital Signs Monitoring, Alert and Diagnosis | A system for monitoring vital signs of a pet animal comprises an annular band, an accelerometer configured to measure at least one of resting patterns, activity patterns, movement patterns, position patterns relating to, for example the pet animal relieving itself, lameness and scratching, and a non-accelerometer senso... | 1. A system for monitoring vital signs of a pet animal, comprising: an annular band having a working surface configured to wrap around a portion of a pet animal; a sensor array comprising at least two sensor elements situated along a circumference of the band, the at least two sensor elements including an accelerometer... | A01K | 20140116 | 2,014 | 2014:12180 |
Robotic Pet Waste Treatment or Collection | A method and apparatus for the detection, treatment or collection of a quantity of solid animal excrement from a surface, particularly a grassy surface. The method includes the steps of autonomously or semi-autonomously detecting the presence of the excrement on the surface, moving a collection/treatment device into po... | 1. A method for locating and treatment of solid or semi-solid animal excrement disposed on a surface, (a) providing a robotically operated vehicle adapted to traverse an area of the surface, (b) detecting at least one selected attribute of a quantity of the excrement disposed on said area of the surface, (c) selecting ... | A01K | 20110617 | 2,011 | 2011:103244 |
PET TOY TREAT DISPENSER | A treat dispenser is provided for an animal to dispense treats by moving the dispenser. The dispenser includes a central spherical body, and a plurality of peripherally spaced spheres or balls connected to the body by respective branches. Each of the balls has a treat dispensing opening. The body has an opening for cha... | 1. A dispenser for dispensing treats, said dispenser comprising: a body having a central cavity and a top central opening for loading treats in said central cavity and for dispensing treats from said central cavity; a plurality of branches connected to said body; and a plurality of ball shaped elements spaced from said... | A01K | 20130313 | 2,013 | 2013:45225 |
HIGH EFFICACY SIGNAL FORMAT & THIN-PROFILE ANKLE-MOUNTING FOR ELECTRONIC SHARK DETERRENT | A device operable as an electronic shark deterrent has a high-voltage pulse signal waveform generator for pulses to be applied to electrodes immersed in water to deter sharks and other aquatic creatures. A preferred output waveform has a train of pulse bursts of alternating-polarity pulses in a series. Preferably, the ... | 1. A device operable as an electronic shark deterrent comprising a high-voltage pulse signal waveform generator for generating an output pulse waveform to be applied to spaced-apart electrodes immersed in water to deter sharks and other aquatic creatures, wherein the output waveform comprises a train of pulse bursts, a... | A01K | 20110329 | 2,011 | 2011:53593 |
Dynamic Canine Tracking Method for Hazardous and Illicit Substances | Vapor wake detection is a highly advantageous method and system for detecting explosives and other illicit substances. With vapor wake detection, a canine and a handler are used; however, unlike other detection schemes, the canine leads the handler. After the handler positions the canine in a desired location, the cani... | 1-6. (canceled) 7. A method of training a canine for detection, the method comprising: choosing a detector canine that demonstrates a high level of independent search behavior; teaching the detector canine that the source of a target odor is not limited to stationary objects; teaching the detector canine to follow it v... | A01K | 20131226 | 2,013 | 2013:237520 |
ANIMAL LITTER | Provided is an animal toilet sand that is less liable to scatter and in which the depth of the solids is less liable to increase when a liquid such as urine has been absorbed. An animal toilet sand composed of a plurality of particulates having water absorbency, wherein the particulates contain: long grains having a gr... | 1. An animal litter composed of a plurality of particulates having a water absorbing property, wherein the particulates include long particles of at least 4 mm and less than 10 mm in grain size that have length greater than diameter, and short particles of at least 4 mm and less than 10 mm in grain size that have lengt... | A01K | 20141126 | 2,014 | 2014:152686 |
RETRIEVING TOOL FOR TRAINING DOGS | A retrieving tool including a retrieving dummy and/or a kit incorporating the same is provided that facilitates training a dog or puppy to find and/or retrieve antlers that were shed by antler bearing animals. The retrieving dummy is shaped to resemble a naturally grown antler and emits an antler scent. A scent carrier... | 1. A retrieving dummy comprising: a dummy body configured to resemble an antler, wherein the dummy body is formed of a material other than natural antler material, and wherein the dummy body comprises a base and a main beam extending from the base; a scent carrier carried by the dummy body and formed of a material diff... | A01K | 20130710 | 2,013 | 2013:125277 |
Interchangeable blade and lure fishing assembly | A fishing lure combination is disclosed which comprises a frame and an oscillating blade which may be affixed to the frame and then replaced without removing or untying a fishing line affixed to the frame. Also, the frame comprises a clip for replacing an associated weighted fishing lure, also without removing or untyi... | 1. A method for providing and using a combination frame and oscillating blade assembly in conjunction with a weighted fishing lure wherein said frame remains securely affixed to a fishing line while one oscillating blade is replaced by another oscillating blade, said method comprising the steps of: (a) providing a wire... | A01K | 20111004 | 2,011 | 2011:124778 |
System for providing an interface for interacting with a laboratory animal | A system for providing an interface for interacting with a laboratory animal and the method of using the system are disclosed. | 1. A system for providing an interface for interacting with a laboratory animal, comprising: a support member having a body and an opening in the body, the support member configured to attach to an animal cage; a first rotating member attached to the support member, the rotating member comprising a first rotation axis ... | A01K | 20130116 | 2,013 | 2013:9796 |
CIRCULATION TYPE AQUACULTURE METHOD AND CIRCULATION TYPE AQUACULTURE DEVICE | A circulation type aquaculture method and a circulation type aquaculture apparatus which treat and remove ammonia harmful to fishes/shellfishes. The method includes a first step of finding an ammonia decomposition rate upon preliminarily treating cultivation water by using ozone or hypochloric acid so as to set a targe... | 1. A circulation type aquaculture method, which is a method for treating cultivation water in a circulation type aquaculture tank in which aquatic organisms are kept by an aquaculture apparatus main body, comprising: a first step of finding an ammonia decomposition rate upon preliminarily treating the cultivation water... | A01K | 20160404 | 2,016 | 2016:20593 |
MICE THAT MAKE VL BINDING PROTEINS | Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice... | 1.-21. (canceled) 22. A mouse whose genome comprises (a) a sequence that includes an unrearranged human light chain variable (VL) gene segment and an unrearranged human light chain joining (JL) gene segment operably linked with a heavy chain constant (CH) region; and (b) a sequence that includes an unrearranged human l... | A01K | 20131219 | 2,013 | 2013:234216 |
ANTIBODY PRODUCING NON-HUMAN MAMMALS | Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodim... | 1. A mouse comprising in its genome a rearranged human variable light chain sequence encoding human variable light chains, wherein the mouse has variety in specificity of antibodies having variable regions consisting of heavy chains and said human variable light chains, and wherein the variety in specificity consists e... | A01K | 20130125 | 2,013 | 2013:14761 |
HUMANIZED IL-4 AND IL-4Ra ANIMALS | Non-human animals comprising a human or humanized IL-4 and/or IL-4Rα nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4Rα gene with a human IL-4 gene and/or IL-4Rα gene in whole or in part, and methods for making and using the non-human animals, are... | 1. A rodent, comprising a humanization of an endogenous rodent IL-4 gene, wherein the humanization comprises a replacement at the endogenous rodent IL-4 locus of a rodent nucleic acid comprising an exon of an IL-4 gene with a nucleic acid sequence comprising at least one exon of a human IL-4 gene to form a modified IL-... | A01K | 20150507 | 2,015 | 2015:80679 |
SYSTEM AND METHOD FOR GROOMING-RELATED FARM DECISION SUPPORT | A method and system providing farm decision support relating to individual animals in a herd in a farm environment includes a brush station having a reader configured to remotely register, via identification devices, an identity of each animal visiting the brush station responsive to a detection unit detecting a reposi... | 1-18. (canceled) 19. A method of providing farm decision support relating to individual animals in a herd in a farm environment, comprising the steps of: associating each animal (A1, A2, A3) with a respective identification device (T1, T2; T3) for automatic remote identifying of each animal; operating a processing devi... | A01K | 20140818 | 2,014 | 2014:139812 |
SYSTEM AND METHOD FOR TRANSPORTING SAND | A conveyor system for transporting sand that is moved outwardly, from a lower end of an enclosure region in at least one animal stall toward a gutter, to a discharge location. The conveyor system includes a conveyor assembly having a transportation element for moving the sand, a drive subassembly for moving the transpo... | 1. A conveyor system for transporting sand that is moved outwardly, from a lower end of an enclosure region in at least one animal stall toward a gutter, to a discharge location, the conveyor system comprising: a conveyor assembly comprising: a transportation element for moving the sand; a drive subassembly for moving ... | A01K | 20150311 | 2,015 | 2015:9313 |
Portable Aquarium Filter Structure | An improved portable aquarium filter structure has a box body, wherein its inside has a submersible pump externally connected to an air pipe. Air enters the submersible pump through the air pipe to mix with water flow pumped by the submersible pump so as to produce bubbles. Accordingly, water flow can be treated with b... | 1. An improved portable aquarium filter structure having a box body, at least one suspension portion capable of being suspended to an aquarium disposed at an outside of the box body, a submersible pump disposed inside the box body, an air pipe externally connected to the submersible pump, air enter the submersible pump... | A01K | 20120525 | 2,012 | 2012:83419 |
NECTAR FEEDER HAVING A FLOAT WITH FLUSH STOPPER | A nectar feeder for hummingbirds is disclosed. The feeder includes a container configured and arranged to store nectar feed. The container has a top end and a bottom end. A spout depends from the bottom end of the container with an exit port defined thereon. A base tray positioned below the container. The base tray is ... | 1. A nectar feeder, comprising: a container configured and arranged to store nectar feed, the container having a top end and a bottom end, the container further having a spout depending from the bottom end of the container with an exit port defined thereon, a base tray positioned below the container, the base tray furt... | A01K | 20130626 | 2,013 | 2013:118664 |
BALLAST WEIGHT FOR A FISHING LINE | A ballast weight for a fishing line, comprising a main body (1) destined to be associated to a fishing line, which comprises a through-channel (10) provided with an inlet opening (11) and an outlet opening (12) located on the external surface of the main body (1), said through-channel (10) being overall orientated in a... | 1. A ballast weight for a fishing line, comprising a main body (1) destined to be associated to a fishing line, characterised in that it comprises a through-channel (10) provided with an inlet opening (11) and an outlet opening (12) located on the external surface of the main body (1), said through-channel (10) being o... | A01K | 20120510 | 2,012 | 2012:76022 |
Animal Kennel for Scientific Examination | An animal kennel comprises front, rear, top, bottom, and opposite side walls that collectively define a cavity. At least a portion of the cavity has a horizontal cross-section that is bordered by the front, rear, and opposite side walls. The cross-section has a front portion and a rear portion. The front portion is nar... | 1. An animal kennel comprising front, rear, top, bottom, and opposite side walls that collectively define a cavity, at least a portion of the cavity having a horizontal cross-section that is bordered by the front, rear, and opposite side walls, the cross-section having a front portion and a rear portion, the front port... | A01K | 20130415 | 2,013 | 2013:80419 |
SPILL-PREVENTIVE PET TRAINING APPARATUS AND METHOD | A spill-preventive pet-training apparatus and method for use in containing the lateral flow of liquid, such as urine, being applied to an absorbent pad at a volume and rate exceeding the absorption rate of the pad, by containing much of the liquid within an inner flexible ridge, and by slowing and containing any liquid... | 1. A spill-preventive pet-training apparatus for use in containing the lateral flow of a volume of liquid during the time required for the liquid to be absorbed, the spill-preventive pet-training apparatus comprising: (i) an impermeable base, defining a horizontal coverage area and having a center portion and a perimet... | A01K | 20160107 | 2,016 | 2016:7506 |
Methods of Detecting Target Nucleic Acids | The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating the modified coded m... | 1-73. (canceled) 74. A method of detecting a target polynucleotide, comprising: a) contacting a coded molecule with a target polynucleotide, wherein the coded molecule comprises (i) one or more block polymer regions, and (ii) a target probe capable of hybridizing to the target polynucleotide; b) modifying the coded mol... | C12Q | 20150702 | 2,015 | 2015:120949 |
ANALYSIS OF DIRECT FACTOR Xa INHIBITORS | The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substa... | 1. Method for detecting at least one direct factor Xa inhibitor in a sample, comprising the steps of: (a) providing a sample containing at least one direct factor Xa inhibitor; (b) providing a composition containing factor Xa; (c) providing a composition containing a chromogenic substrate conjugated to a detectable sub... | C12Q | 20130723 | 2,013 | 2013:94084 |
NOVEL GLUCOSE DEHYDROGENASE | Provided is a flavin adenine dinucleotide-dependent glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 78% or more identity to the amino acid sequence of SEQ ID NO: 3, and having glucose dehydrogenase activity. | 1. A flavin adenine dinucleotide-dependent glucose dehydrogenase comprising a polypeptide having an amino acid sequence with 78% or more identity to the amino acid sequence of SEQ ID NO: 3, and having glucose dehydrogenase activity, wherein the polypeptide does not comprise the amino acid sequence of SEQ ID NO: 3. 2. T... | C12Q | 20160421 | 2,016 | 2016:54856 |
METHODS FOR DIAGNOSING AND TREATING ONCOGENIC KRAS-ASSOCIATED CANCER | Methods for diagnosing and treating cancer associated with an oncogenic Kras mutation in a subject are provided. | 1. A method for diagnosing a cancer associated with an oncogenic Kras mutation in a subject, the method comprising assaying a sample obtained from a subject suspected of having or being at risk of developing said cancer for: (1) an elevated level of expression or activity of one or more polypeptides mediating a functio... | C12Q | 20140620 | 2,014 | 2014:132716 |
USE OF KNOWN COMPOUNDS AS D-AMINO ACID OXIDASE INHIBITORS | The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a p... | 1. A method for selection of a DAAO inhibitor, comprising selecting a drug database; removing compounds containing metal atoms and compounds with molecular weights outside the 100-700 g/mol range; selecting the compound candidates with interaction with more than three residues of Leu51, Gln53, Leu215, His217, Tyr 224, ... | C12Q | 20160913 | 2,016 | 2016:52438 |
HIGH THROUGHPUT DETECTION OF MOLECULAR MARKERS BASED ON AFLP AND HIGH THROUGH-PUT SEQUENCING | The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising (sample-specific) identifiers are ligated. The adapter-ligated restriction fragments may be selectively amplified with adaptor ... | 1. A method for identifying one or more molecular markers in a plurality of samples, comprising: (a) providing a plurality of sample nucleic acids; (b) digesting each sample nucleic acid with at least one restriction endonuclease to obtain a set of restriction fragments; (c) providing at least one double stranded synth... | C12Q | 20140522 | 2,014 | 2014:85539 |
Method Of Making An Electrochemical Sensor Strip | A method of making an electrochemical sensor strip that includes: depositing a first electrode on a base; depositing a second electrode on the base; applying a first layer onto the first electrode; and applying a second layer onto the second electrode. The first layer includes an oxidoreductase and a mediator. The seco... | 1. A method of making an electrochemical sensor strip, comprising: depositing a first electrode on a base; depositing a second electrode on the base; applying a first layer onto the first electrode, the first layer comprising an oxidoreductase and a mediator; and applying a second layer onto the second electrode, the s... | C12Q | 20140221 | 2,014 | 2014:29916 |
STERILISATION INDICATOR | A sterilization indicator having a compound that is of the heating type when put into contact with atoms of oxygen O and/or nitrogen N; and a thermochromic dye, in thermal contact with the compound. | 1. A sterilization indicator comprising: a first portion comprising a compound having at least one metal that is of the heating type when put into contact with atoms of oxygen O and/or nitrogen N, and a first thermochromic dye in thermal contact with the compound, wherein the thermochromic dye changes color due to a ri... | C12Q | 20130222 | 2,013 | 2013:29015 |
Quantification of Human Mitochondrial DNA Using Synthesized DNA Standards | A real-time quantitative PCR assay that utilizes a duplex, synthetic DNA standard to ensure optimal quality assurance and quality control. One embodiment of the invention facilitates amplification of mtDNA by focusing on a 105-base pair target sequence that is minimally homologous to non-human mtDNA. The present invent... | 1. A process for quantifying human mitochondrial DNA, said process comprising: amplifying a region of human mitochondrial DNA by contacting a biological sample containing human mitochondrial DNA with an oligonucleotide primer pair having a nucleotide sequence complementary to a target sequence located within the NADH d... | C12Q | 20120330 | 2,012 | 2012:56325 |
ALL MINI-STR MULTIPLEX WITH INCREASED C.E. THROUGH-PUT BY STR PROLONGATION TEMPLATE FUSION | A longstanding challenge in forensics is maximizing the number of “mini”-short tandem repeat amplicons within the limited confines of fluorescent channels and run length afforded by capillary electrophoresis. The instant disclosure overcomes this longstanding challenge by fusing mini-STR amplicons in a locus specific m... | 1. A method comprising: a. combining DNA, a DNA ligase, a DNA polymerase, ATP, CTP, GTP, TTP, a first primer, a second primer and a prolongation template in a reaction vessel, the first primer and the prolongation template are the reverse complement of a same chromosomal strand, the first primer flanking one side of a ... | C12Q | 20150313 | 2,015 | 2015:55279 |
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