input_text stringlengths 97 2.51k | output_text dict |
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Title : Convalescent plasma in the management of moderate covid - 19 in adults in India : open label phase II multicentre randomised controlled trial ( PLACID Trial ) . METHODS : Open label , parallel arm , phase II , multicentre , randomised controlled trial . 39 public and private hospitals across India . 464 adults ... | {
"P": [
"adults in India",
"464 adults ( ?18 years ) admitted to hospital ( screened 22 April to 14 July 2020 ) with confirmed moderate covid - 19 ( partial pressure of oxygen in arterial blood / fraction of inspired oxygen ( PaO2 / FiO2 ) ratio between 200 mm Hg and 300 mm Hg or a respiratory rate of more t... |
Title : A 6 - month , randomized , double - blind , placebo - controlled pilot discontinuation trial following response to haloperidol treatment of psychosis and agitation in Alzheimer ' s disease . METHODS : In outpatients with AD with symptoms of psychosis or agitation , responders to 20 weeks of haloperidol ( 0 . 5 ... | {
"P": [
"outpatients with AD with symptoms of psychosis or agitation , responders to 20 weeks of haloperidol ( 0 . 5 - 5 mg daily )"
],
"I": [
"haloperidol treatment",
"continuation haloperidol"
],
"C": [
"placebo"
],
"O": [
"three target symptoms",
"the Clinical Global Impression... |
Title : A single - dose pilot trial of intranasal rapid - acting insulin in apolipoprotein E4 carriers with mild - moderate Alzheimer ' s disease . METHODS : We performed a double - blinded , randomized , cross - over study of RA insulin glulisine in nine mild - moderate AD subjects to better understand the relationshi... | {
"P": [
"apolipoprotein E4 carriers with mild - moderate Alzheimer ' s disease",
"nine mild - moderate AD subjects"
],
"I": [
"intranasal rapid - acting insulin",
"RA insulin glulisine"
],
"C": [],
"O": [
"RA insulin",
"ApoE4 carrier status",
"memory performance"
]
} |
Title : Early versus deferred anti - SARS - CoV - 2 convalescent plasma in patients admitted for COVID - 19 : A randomized phase II clinical trial . | {
"P": [
"patients admitted for COVID - 19"
],
"I": [
"Early",
"deferred anti - SARS - CoV - 2 convalescent plasma"
],
"C": [],
"O": []
} |
Title : A multicenter double - blind study of controlled - release physostigmine for the treatment of symptoms secondary to Alzheimer ' s disease . Physostigmine Study Group . METHODS : During dose titration , subjects received 18 , 24 , or 30 mg of physostigmine or placebo daily . After a 2 - week washout period , 366... | {
"P": [
"366 subjects with putative improvement"
],
"I": [
"controlled - release physostigmine",
"18",
"24",
"30 mg of physostigmine",
"their best dose of physostigmine",
"their highest tolerated dose of physostigmine"
],
"C": [
"placebo"
],
"O": [
"the cognitive subsc... |
Title : Tofacitinib in Patients Hospitalized with Covid - 19 Pneumonia . METHODS : We randomly assigned , in a 1 : 1 ratio , hospitalized adults with Covid - 19 pneumonia to receive either tofacitinib at a dose of 10 mg or placebo twice daily for up to 14 days or until hospital discharge . The primary outcome was the o... | {
"P": [
"Patients Hospitalized with Covid - 19 Pneumonia",
"hospitalized adults with Covid - 19 pneumonia"
],
"I": [
"Tofacitinib",
"tofacitinib"
],
"C": [
"placebo"
],
"O": [
"the occurrence of death",
"respiratory failure",
"the use of an eight - level ordinal scale",
... |
Title : Probiotic and selenium co - supplementation , and the effects on clinical , metabolic and genetic status in Alzheimer ' s disease : A randomized , double - blind , controlled trial . METHODS : This randomized , double - blind , controlled clinical trial was conducted among 79 patients with AD . Patients were ra... | {
"P": [
"79 patients with AD"
],
"I": [
"Probiotic",
"selenium co - supplementation",
"selenium",
"probiotic",
"Lactobacillus acidophilus",
"Bifidobacterium bifidum",
"Bifidobacterium longum"
],
"C": [
"placebo"
],
"O": []
} |
Title : The Humanoid Robot Sil - Bot in a Cognitive Training Program for Community - Dwelling Elderly People with Mild Cognitive Impairment during the COVID - 19 Pandemic : A Randomized Controlled Trial . METHODS : A randomized controlled trial was conducted with 135 volunteers without cognitive impairment aged 60 year... | {
"P": [
"Community - Dwelling Elderly People with Mild Cognitive Impairment during the COVID - 19 Pandemic",
"135 volunteers without cognitive impairment aged 60 years old or older"
],
"I": [
"The Humanoid Robot Sil - Bot in a Cognitive Training Program",
"cognitive training",
"The cognitive ... |
Title : Efficacy of donepezil in early - stage Alzheimer disease : a randomized placebo - controlled trial . METHODS : Multicenter , randomized , double - blind , 24 - week , placebo - controlled study that enrolled patients with early - stage Alzheimer disease . Patients were randomized in an approximately 2 : 1 ratio... | {
"P": [
"patients with early - stage Alzheimer disease"
],
"I": [
"donepezil"
],
"C": [
"placebo"
],
"O": [
"the modified Alzheimer Disease Assessment Scale - cognitive subscale",
"the Mini - Mental State Examination",
"the Computerized Memory Battery Test",
"the Clinical Deme... |
Title : Oseltamivir for coronavirus illness : post - hoc exploratory analysis of an open - label , pragmatic , randomised controlled trial in European primary care from 2016 to 2018 . METHODS : Exploratory analysis of data from an open - label , pragmatic , randomised controlled trial during three influenza seasons , f... | {
"P": [
"Patients aged ?1 year presenting to primary care with influenza - like illness ( ILI ) , and who tested positive for coronavirus ( not including SARS - CoV - 2 )"
],
"I": [
"Oseltamivir",
"usual care",
"oseltamivir"
],
"C": [
"usual care"
],
"O": [
"time to recovery",
... |
Title : Exploring an Integrative Therapy for Treating COVID - 19 : A Randomized Controlled Trial . METHODS : A putative ARDS - suppressing drug Keguan - 1 was first developed and then evaluated by a randomized , controlled two - arm trial . The two arms of the trial consist of a control therapy ( alpha interferon inhal... | {
"P": [
"newly diagnosed COVID - 19 patients"
],
"I": [
"A putative ARDS - suppressing drug Keguan - 1",
"Keguan - 1"
],
"C": [
"alpha interferon inhalation",
"lopinavir",
"ritonavir"
],
"O": [
"adverse events",
"time to fever resolution",
"ARDS development",
"lung... |
Title : Effect of Ammonium Chloride in addition to standard of care in outpatients and hospitalized COVID - 19 patients : A randomized clinical trial . METHODS : In this double - blind , single - center study , we enrolled patients with positive PCR test and / or CT findings for COVID - 19 . The participants of each gr... | {
"P": [
"outpatients and hospitalized COVID - 19 patients",
"patients with positive PCR test and / or CT findings for COVID - 19"
],
"I": [
"Ammonium Chloride",
"standard of care",
"Diphenhydramine Compound",
"Diphenhydramine"
],
"C": [
"Diphenhydramine alone",
"standard of ca... |
Title : Remdesivir for the Treatment of Covid - 19 - Final Report . METHODS : We conducted a double - blind , randomized , placebo - controlled trial of intravenous remdesivir in adults who were hospitalized with Covid - 19 and had evidence of lower respiratory tract infection . Patients were randomly assigned to recei... | {
"P": [
"adults who were hospitalized with Covid - 19 and had evidence of lower respiratory tract infection"
],
"I": [
"Remdesivir",
"intravenous remdesivir",
"remdesivir"
],
"C": [
"placebo"
],
"O": [
"the time to recovery",
"discharge from the hospital",
"hospitalization... |
Title : Effects of progressive muscle relaxation on anxiety and sleep quality in patients with COVID - 19 . METHODS : In this randomized controlled clinical trial , a total of 51 patients who entered the isolation ward were included in the study and randomly divided into experimental and control groups . The experiment... | {
"P": [
"patients with COVID - 19",
"a total of 51 patients who entered the isolation ward"
],
"I": [
"progressive muscle relaxation",
"progressive muscle relaxation ( PMR ) technology"
],
"C": [
"only routine care",
"treatment"
],
"O": [
"the Spielberger State - Trait Anxiety... |
Title : Cognitive outcomes after sertaline treatment in patients with depression of Alzheimer disease . METHODS : Placebo - controlled , randomized , double - blind trial . Outpatient memory clinics at five academic medical centers in the United States . A total of 131 patients with dAD ( 60 men ) and Mini - Mental Sta... | {
"P": [
"patients with depression of Alzheimer disease",
"A total of 131 patients with dAD ( 60 men ) and Mini - Mental State Examination scores of 10 - 26"
],
"I": [
"sertaline treatment",
"Sertraline"
],
"C": [
"matching placebo"
],
"O": [
"Mini - Mental State Examination",
... |
Title : Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS - CoV - 2 Infected Subjects : A Pilot Clinical Trial in Lebanon . METHODS : A randomized controlled trial was conducted in 100 asymptomatic Lebanese subjects that have tested positive for SARS - CoV2 . Fifty patients rece... | {
"P": [
"Asymptomatic SARS - CoV - 2 Infected Subjects",
"100 asymptomatic Lebanese subjects that have tested positive for SARS - CoV2"
],
"I": [
"a Single Dose of Ivermectin",
"a single dose ( according to body weight ) of ivermectin",
"the same supplements"
],
"C": [
"standard preve... |
Title : Long - Term Extensions of Randomized Vaccination Trials of ACC - 001 and QS - 21 in Mild to Moderate Alzheimer ' s Disease . METHODS : Phase 2 a extension studies of randomized parent trials were conducted in the United States , European Union , and Japan . Four immunizations of ACC - 001 were administered at t... | {
"P": [
"subjects randomized in the parent studies"
],
"I": [
"ACC - 001",
"QS - 21"
],
"C": [],
"O": [
"Safety",
"tolerability",
"immunogenicity"
]
} |
Title : Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID - 19 : A Randomized Clinical Trial . METHODS : This was a multicenter , double - blind , randomized , placebo - controlled trial conducted in 2 sites in Sao Paulo , Brazil . The study included 240 hos... | {
"P": [
"Patients With Moderate to Severe COVID - 19",
"240 hospitalized patients with COVID - 19 who were moderately to severely ill at the time of enrollment from June 2 , 2020 , to August 27 , 2020 . The final follow - up was on October 7 , 2020"
],
"I": [
"a Single High Dose of Vitamin D3",
"... |
Title : Randomized clinical trial " olfactory dysfunction after COVID - 19 : olfactory rehabilitation therapy vs . intervention treatment with Palmitoylethanolamide and Luteolin " : preliminary results . METHODS : We conducted a randomized - controlled pilot study in outpatients with history of confirmed COVID - 19 wit... | {
"P": [
"outpatients with history of confirmed COVID - 19 with post - infection olfactory impairment that persisted ? 90 days after SARS - CoV - 2 negative testing"
],
"I": [
"Palmitoylethanolamide",
"Luteolin",
"weekly olfactory rehabilitation",
"daily oral supplement with PEA"
],
"C": [... |
Title : Effect of timed bright light treatment for rest - activity disruption in institutionalized patients with Alzheimer ' s disease . METHODS : The purpose of this randomized clinical trial was to test the effectiveness of timed bright light therapy in reducing rest - activity ( circadian ) disruption in institution... | {
"P": [
"institutionalized patients with Alzheimer ' s disease",
"institutionalized patients with AD"
],
"I": [
"timed bright light treatment",
"timed bright light therapy",
"morning ( 9 . 30 - 10 . 30 am )",
"afternoon ( 3 . 30 - 4 . 30 pm ) bright light exposure"
],
"C": [
"usua... |
Title : Keep music live : music and the alleviation of apathy in dementia subjects . METHODS : Thirty - two subjects meeting ICD - 10 diagnostic criteria for moderate to severe dementia and fulfilling diagnostic criteria for apathy were exposed to live interactive music , passive pre - recorded music or silence for 30 ... | {
"P": [
"dementia subjects",
"Thirty - two subjects meeting ICD - 10 diagnostic criteria for moderate to severe dementia and fulfilling diagnostic criteria for apathy"
],
"I": [
"music",
"live interactive music",
"passive pre - recorded music",
"silence"
],
"C": [],
"O": [
"deme... |
Title : Brief psychotherapy in Alzheimer ' s disease : randomised controlled trial . METHODS : Individuals were randomised to receive six sessions of psychodynamic interpersonal therapy or treatment as usual ; cognitive function , activities of daily living , a global measure of change , and carer stress and coping wer... | {
"P": [],
"I": [
"Brief psychotherapy",
"psychodynamic interpersonal therapy"
],
"C": [
"treatment as usual"
],
"O": [
"cognitive function",
"activities of daily living",
"a global measure of change",
"carer stress",
"coping"
]
} |
Title : Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients . | {
"P": [
"Alzheimer patients"
],
"I": [
"Different cholinesterase inhibitor"
],
"C": [],
"O": []
} |
Title : Intravenous high - dose vitamin C for the treatment of severe COVID - 19 : study protocol for a multicentre randomised controlled trial . METHODS : The investigators designed a multicentre prospective randomised placebo - controlled trial that is planned to recruit 308 adults diagnosed with COVID - 19 and trans... | {
"P": [
"308 adults diagnosed with COVID - 19 and transferred into the intensive care unit"
],
"I": [
"Intravenous high - dose vitamin C",
"HIVC"
],
"C": [
"placebo"
],
"O": [
"ventilation - free days"
]
} |
Title : Effect of Discontinuing vs Continuing Angiotensin - Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID - 19 : A Randomized Clinical Trial . METHODS : A randomized clinical trial of 659 patients hospitalized in Brazil with mild ... | {
"P": [
"Patients Admitted With COVID - 19",
"659 patients hospitalized in Brazil with mild to moderate COVID - 19 who were taking ACEIs or ARBs prior to hospitalization ( enrolled : April 9 - June 26 , 2020 ; final follow - up : July 26 , 2020 )"
],
"I": [
"Discontinuing",
"Continuing Angiotensi... |
Title : Effect of Oral Azithromycin vs Placebo on COVID - 19 Symptoms in Outpatients With SARS - CoV - 2 Infection : A Randomized Clinical Trial . METHODS : Randomized clinical trial of azithromycin vs matching placebo conducted from May 2020 through March 2021 . Outpatients from the US were enrolled remotely via inter... | {
"P": [
"Outpatients With SARS - CoV - 2 Infection",
"Outpatients from the US"
],
"I": [
"Oral Azithromycin",
"azithromycin",
"a single oral 1 . 2 - g dose of azithromycin"
],
"C": [
"Placebo",
"matching placebo"
],
"O": [
"absence of self - reported COVID - 19 symptoms",
... |
Title : A double - blind , placebo - controlled , multicenter study of Cerebrolysin for Alzheimer ' s disease . METHODS : A 4 - week randomized , double - blind , placebo - controlled , multicenter clinical trial . An unequal ( Cerebrolysin : placebo = 2 : 1 ) randomization was used to assign more patients to the treat... | {
"P": [
"Fifty - three men and women at least 50 years of age admitted to hospitals with mild to moderate AD and otherwise in good health"
],
"I": [
"Cerebrolysin",
"30 mL Cerebrolysin"
],
"C": [
"placebo"
],
"O": [
"the Alzheimer ' s Disease Assessment Scale - Cognitive subscale ( AD... |
Title : 11 C - PiB PET assessment of change in fibrillar amyloid - beta load in patients with Alzheimer ' s disease treated with bapineuzumab : a phase 2 , double - blind , placebo - controlled , ascending - dose study . METHODS : Patients with mild - to - moderate Alzheimer ' s disease were randomly assigned to receiv... | {
"P": [
"patients with Alzheimer ' s disease",
"Patients with mild - to - moderate Alzheimer ' s disease"
],
"I": [
"bapineuzumab",
"intravenous bapineuzumab",
"the pooled bapineuzumab"
],
"C": [
"placebo",
"the pooled placebo"
],
"O": [
"( 11 ) C - PiB cortical to cerebel... |
Title : A randomized , double - blind , placebo - controlled trial of simvastatin to treat Alzheimer disease . METHODS : This randomized , double - blind , placebo - controlled trial of simvastatin was conducted in individuals with mild to moderate AD and normal lipid levels . Participants were randomly assigned to rec... | {
"P": [
"individuals with mild to moderate AD and normal lipid levels"
],
"I": [
"simvastatin"
],
"C": [
"identical placebo"
],
"O": [
"the Alzheimer ' s Disease Assessment Scale - cognitive portion ( ADAS - Cog )",
"clinical global change",
"cognition",
"function",
"behav... |
Title : Home - Based Exercise Program Improves Balance and Fear of Falling in Community - Dwelling Older Adults with Mild Alzheimer ' s Disease : A Pilot Study . METHODS : A prospective randomized controlled parallel - group trial ( Wii - Fit versus walking ) was conducted in thirty community - dwelling older adults ( ... | {
"P": [
"Community - Dwelling Older Adults with Mild Alzheimer ' s Disease",
"thirty community - dwelling older adults ( 736 . 2 years ) with mild AD"
],
"I": [
"Home - Based Exercise Program",
"Wii - Fit",
"walking",
"Home - based exercises"
],
"C": [],
"O": [
"Berg Balance Sca... |
Title : Efficacy of Hearing Aids on the Cognitive Status of Patients with Alzheimer ' s Disease and Hearing Loss : A Multicenter Controlled Randomized Trial . METHODS : A multicenter double - blind randomized placebo - controlled trial was conducted in patients aged more than 65 years . A group was equipped with active... | {
"P": [
"Patients with Alzheimer ' s Disease and Hearing Loss",
"patients aged more than 65 years"
],
"I": [
"Hearing Aids",
"active HA",
"HA"
],
"C": [
"placebo HA"
],
"O": [
"the Alzheimer ' s Disease Assessment Scale - Cognitive subscale ( ADAS Cog )",
"ADAS Cog score"
... |
Title : Itraconazole for COVID - 19 : preclinical studies and a proof - of - concept randomized clinical trial . METHODS : Due to the initial absence of preclinical models , the effect of itraconazole was explored in a clinical , proof - of - concept , open - label , single - center study , in which hospitalized COVID ... | {
"P": [
"hospitalized COVID - 19 patients"
],
"I": [
"Itraconazole",
"itraconazole",
"standard of care"
],
"C": [],
"O": [
"the cumulative score of the clinical status",
"the 7 - point ordinal scale of the World Health Organization"
]
} |
Title : A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI . METHODS : For a 2 - year , double - blinded , placebo - controlled study MCI patients , presenting with an amnestic syndrome but not necessarily based on presumed prodromal AD were randomized . Patients receiv... | {
"P": [
"subjects with amnestic MCI",
"MCI patients , presenting with an amnestic syndrome but not necessarily based on presumed prodromal AD"
],
"I": [
"galantamine",
"memantine",
"16 mg galantamine",
"20 mg memantine"
],
"C": [
"placebo"
],
"O": [
"the progression to dem... |
Title : Music therapy in moderate and severe dementia of Alzheimer ' s type : a case - control study . METHODS : This case - control study was carried out by qualified music therapists in two nursing homes and two psychogeriatric wards . The participants were 38 patients with moderate or severe Alzheimer ' s disease ( ... | {
"P": [
"38 patients with moderate or severe Alzheimer ' s disease ( AD )"
],
"I": [
"Music therapy",
"a music therapy"
],
"C": [],
"O": []
} |
Title : [ Effect of Xuebijing injection on inflammatory markers and disease outcome of coronavirus disease 2019 ] . METHODS : Sixty severe COVID - 19 patients admitted to Changsha Public Health Treatment Center ( North Hospital of the First Hospital of Changsha City ) from January to March in 2020 were randomly divided... | {
"P": [
"Sixty severe COVID - 19 patients admitted to Changsha Public Health Treatment Center ( North Hospital of the First Hospital of Changsha City ) from January to March in 2020"
],
"I": [
"Xuebijing injection",
"Xuebijing"
],
"C": [
"routine treatment"
],
"O": [
"The blood routin... |
Title : The value of high - flow nasal cannula oxygen therapy in treating novel coronavirus pneumonia . METHODS : The clinical data of 22 patients with severe COVID - 19 were collected . The heart rate ( HR ) , respiratory rate ( RR ) and oxygenation index ( PO2 / FiO2 ) at 0 , 6 , 24 and 72 hours after treatment were ... | {
"P": [
"22 patients with severe COVID - 19"
],
"I": [
"high - flow nasal cannula oxygen therapy",
"the HFNC oxygen therapy"
],
"C": [
"the conventional oxygen therapy ( COT )"
],
"O": [
"The heart rate ( HR )",
"respiratory rate ( RR )",
"oxygenation index",
"PO2",
"F... |
Title : Dose effects associated with rivastigmine transdermal patch in patients with mild - to - moderate Alzheimer ' s disease . METHODS : This was a retrospective analysis of a large , international , 24 - week , randomised , placebo - and active - controlled trial ( IDEAL , CENA713D2320 ) of rivastigmine in patients... | {
"P": [
"patients with mild - to - moderate Alzheimer ' s disease",
"patients with mild - to - moderate Alzheimer ' s disease ( AD )"
],
"I": [
"rivastigmine transdermal patch",
"rivastigmine",
"the 9 . 5 mg / 24 h rivastigmine patch",
"the 17 . 4 mg / 24 h rivastigmine patch",
"12 mg... |
Title : The Efficacy of Computerized Cognitive Behavioral Therapy for Depressive and Anxiety Symptoms in Patients With COVID - 19 : Randomized Controlled Trial . METHODS : We customized a cCBT program focused on improving depressive and anxiety symptoms among patients with COVID - 19 , and then , we assessed its effect... | {
"P": [
"Patients With COVID - 19",
"patients with COVID - 19",
"A total of 252 patients with COVID - 19 at five sites"
],
"I": [
"Computerized Cognitive Behavioral Therapy",
"a cCBT program",
"cCBT",
"treatment as usual ( TAU",
"The cCBT",
"TAU",
"the cCBT intervention pr... |
Title : Effect of Exercise on Drug - Related Falls Among Persons with Alzheimer ' s Disease : A Secondary Analysis of the FINALEX Study . METHODS : In the FINALEX trial , community - dwelling persons with AD received either home - based or group - based exercise twice weekly for 1 year ( n =129 ) ; the control group re... | {
"P": [
"Persons with Alzheimer ' s Disease",
"community - dwelling persons with AD"
],
"I": [
"Exercise",
"home - based",
"group - based exercise"
],
"C": [
"normal care"
],
"O": [
"the incidence rate ratios ( IRRs ) for falls"
]
} |
Title : CORonavirus - 19 mild to moderate pneumonia Management with blood Ozonization in patients with Respiratory failure ( CORMOR ) multicentric prospective randomized clinical trial . METHODS : The trial ( ClinicalTrial . gov NCT04388514 ) was conducted in four different Italian centers ( April - October 2020 ) . Pa... | {
"P": [
"patients with Respiratory failure"
],
"I": [
"blood Ozonization",
"best available standard of care ( SoC ) therapy",
"with"
],
"C": [
"without O3 - autohemotherapy ( O3 - AHT )"
],
"O": []
} |
Title : Memantine treatment in mild to moderate Alzheimer disease : a 24 - week randomized , controlled trial . METHODS : This was a randomized , double - blind , placebo - controlled clinical trial conducted at 42 U . S . sites . Participants were 403 outpatients with mild to moderate AD and Mini - Mental State Examin... | {
"P": [
"403 outpatients with mild to moderate AD and Mini - Mental State Examination scores of 10 - 22"
],
"I": [
"Memantine treatment",
"memantine"
],
"C": [
"placebo"
],
"O": [
"the Alzheimer ' s Disease Assessment Scale - Cognitive Subscale ( ADAS - cog )",
"cognition",
"t... |
Title : Cytokine adsorption in patients with severe COVID - 19 pneumonia requiring extracorporeal membrane oxygenation ( CYCOV ) : a single centre , open - label , randomised , controlled trial . METHODS : We did a single - centre , open - label , randomised , controlled trial to investigate cytokine adsorption in adul... | {
"P": [
"patients with severe COVID - 19 pneumonia requiring extracorporeal membrane oxygenation",
"adult patients with severe COVID - 19 pneumonia requiring ECMO",
"Patients with COVID - 19 selected for ECMO at the Freiburg University Medical Center ( Freiburg , Germany )"
],
"I": [
"Cytokine ad... |
Title : Escitalopram versus risperidone for the treatment of behavioral and psychotic symptoms associated with Alzheimer ' s disease : a randomized double - blind pilot study . METHODS : Inpatients with AD , who had been hospitalized because of behavioral symptoms , were recruited to a six - week randomized , double - ... | {
"P": [
"Inpatients with AD , who had been hospitalized because of behavioral symptoms"
],
"I": [
"Escitalopram",
"risperidone",
"once daily risperidone",
"escitalopram"
],
"C": [],
"O": []
} |
Title : Metrifonate benefits cognitive , behavioral , and global function in patients with Alzheimer ' s disease . METHODS : A prospective , 36 - week , multicenter , double - blind , randomized , parallel group study of metrifonate in probable AD patients , including a 2 - week screening period , a 26 - week double - ... | {
"P": [
"patients with Alzheimer ' s disease",
"probable AD patients",
"A total of 408 patients"
],
"I": [
"Metrifonate",
"metrifonate",
"the metrifonate"
],
"C": [
"the placebo",
"Placebo"
],
"O": [
"the Alzheimer ' s Disease Assessment Scale - Cognitive Subscale ( AD... |
Title : A family intervention to delay nursing home placement of patients with Alzheimer disease . A randomized controlled trial . METHODS : Randomized controlled intervention study . Outpatient research clinic in the New York City metropolitan area . Referred , volunteer sample of 206 spouse - caregivers of AD patient... | {
"P": [
"patients with Alzheimer disease",
"Referred , volunteer sample of 206 spouse - caregivers of AD patients who enrolled in the study during a 3 1 / 2 - year period"
],
"I": [
"A family intervention",
"6 sessions of individual and family counseling"
],
"C": [],
"O": [
"Time from e... |
Title : Methylprednisolone or dexamethasone , which one is superior corticosteroid in the treatment of hospitalized COVID - 19 patients : a triple - blinded randomized controlled trial . METHODS : In this prospective triple - blinded randomized controlled trial , we enrolled 86 hospitalized COVID - 19 patients from Aug... | {
"P": [
"hospitalized COVID - 19 patients",
"86 hospitalized COVID - 19 patients from August to November 2020 , in Shiraz , Iran"
],
"I": [
"Methylprednisolone",
"methylprednisolone"
],
"C": [
"dexamethasone"
],
"O": [
"a 9 - point WHO ordinal scale"
]
} |
Title : Azithromycin for community treatment of suspected COVID - 19 in people at increased risk of an adverse clinical course in the UK ( PRINCIPLE ) : a randomised , controlled , open - label , adaptive platform trial . METHODS : In this UK - based , primary care , open - label , multi - arm , adaptive platform rando... | {
"P": [
"people at increased risk of an adverse clinical course in the UK",
"people at increased risk of an adverse clinical course",
"people aged 65 years and older , or 50 years and older with at least one comorbidity , who had been unwell for 14 days or less with suspected COVID - 19"
],
"I": [
... |
Title : Sarilumab in patients admitted to hospital with severe or critical COVID - 19 : a randomised , double - blind , placebo - controlled , phase 3 trial . METHODS : We did a 60 - day , randomised , double - blind , placebo - controlled , multinational phase 3 trial at 45 hospitals in Argentina , Brazil , Canada , C... | {
"P": [
"patients admitted to hospital with severe or critical COVID - 19",
"adults ( ?18 years ) admitted to hospital with laboratory - confirmed SARS - CoV - 2 infection and pneumonia , who required oxygen supplementation or intensive care"
],
"I": [
"Sarilumab",
"intravenous sarilumab",
"s... |
Title : COvid - 19 and high - dose VITamin D supplementation TRIAL in high - risk older patients ( COVIT - TRIAL ) : study protocol for a randomized controlled trial . METHODS : The COVIT - TRIAL study is an open - label , multicenter , randomized controlled superiority trial . Patients aged ? 65 years with COVID - 19 ... | {
"P": [
"high - risk older patients",
"Patients aged ? 65 years with COVID - 19 ( diagnosed within the preceding 3 days with RT - PCR and / or chest CT scan ) and at least one worsening risk factor at the time of inclusion ( i . e . , age ? 75 years , or SpO2 ? 94 % in room air , or PaO2 / FiO2 ? 300 mmHg ) ... |
Title : Transcranial direct current stimulation as a memory enhancer in patients with Alzheimer ' s disease : a randomized , placebo - controlled trial . METHODS : We conducted a randomized , placebo - controlled clinical trial in which tDCS was applied in six 30 - minute sessions for 10 days . tDCS was delivered to th... | {
"P": [
"patients with Alzheimer ' s disease",
"A total of 25 patients with Alzheimer ' s disease"
],
"I": [
"Transcranial direct current stimulation",
"tDCS",
"active stimulation"
],
"C": [
"placebo stimulation"
],
"O": [
"two parallel versions of the California Verbal Learni... |
Title : REGN - COV2 , a Neutralizing Antibody Cocktail , in Outpatients with Covid - 19 . METHODS : In this ongoing , double - blind , phase 1 - 3 trial involving nonhospitalized patients with Covid - 19 , we investigated two fully human , neutralizing monoclonal antibodies against severe acute respiratory syndrome cor... | {
"P": [
"Outpatients with Covid - 19",
"nonhospitalized patients with Covid - 19"
],
"I": [
"REGN - COV2",
"a Neutralizing Antibody Cocktail",
"a combined cocktail",
"2 . 4 g of REGN - COV2",
"8 . 0 g of REGN - COV2"
],
"C": [
"placebo"
],
"O": [
"viral load",
"the... |
Title : Does behavioral improvement with haloperidol or trazodone treatment depend on psychosis or mood symptoms in patients with dementia ? . METHODS : Randomized , double - blind , parallel - group , 9 - week treatment trial . Inpatient geropsychiatry unit . Twenty - eight patients with dementia and agitated or aggre... | {
"P": [
"patients with dementia",
"Twenty - eight patients with dementia and agitated or aggressive behaviors"
],
"I": [
"haloperidol",
"trazodone treatment",
"Haloperidol",
"trazodone"
],
"C": [],
"O": [
"Cohen - Mansfield Agitation Inventory ( CMAI )",
"Hamilton Depression... |
Title : Safety , pharmacokinetics and exploratory pro - cognitive effects of HTL0018318 , a selective M 1 receptor agonist , in healthy younger adult and elderly subjects : a multiple ascending dose study . METHODS : This randomised , double blind , placebo - controlled study was performed , investigating oral doses of... | {
"P": [
"healthy younger adult and elderly subjects",
"7 cohorts of healthy younger adult ( n = 36 ; 3 cohorts ) and elderly ( n = 50 ; 4 cohorts ) subjects"
],
"I": [
"HTL0018318",
"a selective M 1 receptor agonist",
"oral doses of 15 - 35 mg / day HTL0018318"
],
"C": [
"placebo"
]... |
Title : Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild - to - moderate Alzheimer ' s disease . METHODS : Subjects with mild ( RCT1 , RCT2 ) or mild - to - moderate AD ( RCT3 ) received active or control product once daily for 12 - 24 weeks or active product during the 24 - ... | {
"P": [
"Subjects with mild ( RCT1 , RCT2 ) or mild - to - moderate AD ( RCT3 )"
],
"I": [
"Souvenaid"
],
"C": [],
"O": [
"plasma levels of B vitamins",
"choline",
"vitamin E",
"selenium",
"uridine",
"homocysteine",
"proportions of DHA",
"EPA",
"total n - 3 long ... |
Title : Effects of the Acetylcholine Release Agent ST101 with Donepezil in Alzheimer ' s Disease : A Randomized Phase 2 Study . METHODS : A phase 2 double blind , placebo - controlled study enrolled 210 AD patients ( MMSE 10 - 20 ) on 10 mg donepezil QD . Patients received ST101 ( 10 , 60 , or 120 mg QD ) or placebo fo... | {
"P": [
"210 AD patients ( MMSE 10 - 20 )"
],
"I": [
"the Acetylcholine Release Agent ST101",
"Donepezil",
"10 mg donepezil QD",
"ST101"
],
"C": [
"placebo"
],
"O": [
"cognitive function",
"ADAS - cog"
]
} |
Title : Discontinuation versus continuation of renin - angiotensin - system inhibitors in COVID - 19 ( ACEI - COVID ) : a prospective , parallel group , randomised , controlled , open - label trial . METHODS : ACEI - COVID was a parallel group , randomised , controlled , open - label trial done at 35 centres in Austria... | {
"P": [
"Patients aged 18 years and older"
],
"I": [
"Discontinuation",
"continuation of renin - angiotensin - system inhibitors",
"discontinuation",
"continuation of RAS inhibition"
],
"C": [],
"O": [
"the maximum sequential organ failure assessment ( SOFA ) score",
"area under... |
Title : Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID - 19 ( DARE - 19 ) : a randomised , double - blind , placebo - controlled , phase 3 trial . METHODS : DARE - 19 was a randomised , double - blind , placebo - controlled trial of patients hospitalised with COVID - 19 and with at ... | {
"P": [
"patients with cardiometabolic risk factors hospitalised with COVID - 19",
"patients hospitalised with COVID - 19 and with at least one cardiometabolic risk factor ( ie , hypertension , type 2 diabetes , atherosclerotic cardiovascular disease , heart failure , and chronic kidney disease )"
],
"I"... |
Title : Nutritional Guidance Improves Nutrient Intake and Quality of Life , and May Prevent Falls in Aged Persons with Alzheimer Disease Living with a Spouse ( NuAD Trial ) . METHODS : Randomised controlled trial . Persons with AD living with a spouse . Tailored nutritional guidance with home visits during one year . T... | {
"P": [
"Aged Persons with Alzheimer Disease Living with a Spouse",
"Persons with AD living with a spouse",
"older adults and all community - provided normal care"
],
"I": [
"Nutritional Guidance",
"Tailored nutritional guidance"
],
"C": [
"a written guide"
],
"O": [
"weight c... |
Title : Progesterone in Addition to Standard of Care vs Standard of Care Alone in the Treatment of Men Hospitalized With Moderate to Severe COVID - 19 : A Randomized , Controlled Pilot Trial . METHODS : We conducted a pilot , randomized , open - label , controlled trial of subcutaneous progesterone in men hospitalized ... | {
"P": [
"Men Hospitalized With Moderate to Severe COVID - 19",
"men hospitalized with confirmed moderate to severe COVID - 19"
],
"I": [
"Progesterone",
"Standard of Care",
"subcutaneous progesterone",
"SOC",
"progesterone"
],
"C": [
"Standard of Care Alone",
"SOC alone"
... |
Title : Effect of nasal corticosteroid in the treatment of anosmia due to COVID - 19 : A randomised double - blind placebo - controlled study . METHODS : The study was designed as a randomised , double - blind , placebo - controlled clinical trial . In total , 276 PCR - confirmed COVID - 19 patients who were presented ... | {
"P": [
"276 PCR - confirmed COVID - 19 patients who were presented to the outpatient clinic with anosmia"
],
"I": [
"nasal corticosteroid",
"the betamethasone",
"nasal drops of betamethasone"
],
"C": [
"Similar dose of 9 % NaCl",
"the placebo"
],
"O": []
} |
Title : Effectiveness of Anti - Dementia Drugs in Extremely Severe Alzheimer ' s Disease : A 12 - Week , Multicenter , Randomized , Single - Blind Study . METHODS : In this randomized and rater - blinded trial , 65 AD patients with a Mini - Mental State Examination score from 0 to 5 and a score of 6 c or worse on Funct... | {
"P": [
"65 AD patients with a Mini - Mental State Examination score from 0 to 5 and a score of 6 c or worse on Functional Assessment Staging"
],
"I": [
"Anti - Dementia Drugs",
"an ADD - continuation",
"an ADD - discontinuation",
"the ADD - continuation",
"the ADD - discontinuation"
],... |
Title : SARS - CoV - 2 clearance in COVID - 19 patients with Novaferon treatment : A randomized , open - label , parallel - group trial . METHODS : In the laboratory , Novaferon ' s inhibition of viral replication in cells infected with SARS - CoV - 2 , and prevention of SARS - CoV - 2 entry into healthy cells was dete... | {
"P": [
"COVID - 19 patients"
],
"I": [
"Novaferon",
"Lopinavir",
"Ritonavir"
],
"C": [],
"O": [
"the SARS - CoV - 2 clearance rates",
"the time to SARS - CoV - 2 clearance"
]
} |
Title : Standard Care Versus Awake Prone Position in Adult Nonintubated Patients With Acute Hypoxemic Respiratory Failure Secondary to COVID - 19 Infection - A Multicenter Feasibility Randomized Controlled Trial . METHODS : 60 patients with acute hypoxic respiratory failure secondary to COVID - 19 pneumonia requiring 4... | {
"P": [
"Adult Nonintubated Patients With Acute Hypoxemic Respiratory Failure Secondary to COVID - 19 Infection",
"60 patients with acute hypoxic respiratory failure secondary to COVID - 19 pneumonia requiring 4 or more liters of oxygen to maintain a saturation of ?92 %"
],
"I": [
"Awake Prone Positi... |
Title : Memantine in severe dementia : results of the 9 M - Best Study ( Benefit and efficacy in severely demented patients during treatment with memantine ) . METHODS : Dementia was defined by DSM - III - R criteria and severity was assessed by the Global Deterioration Scale ( stages 5 - 7 ) and the Mini - Mental Stat... | {
"P": [
"severely demented patients during treatment with memantine"
],
"I": [
"Memantine"
],
"C": [],
"O": [
"the Clinical Global Impression of Change ( CGI - C )",
"the Behavioural Rating Scale for Geriatric Patients ( BGP ) , subscore ' care dependence '",
"the modified D - Scale ( A... |
Title : Standard prophylactic versus intermediate dose enoxaparin in adults with severe COVID - 19 : A multi - center , open - label , randomized controlled trial . METHODS : We conducted a multi - center , open - label , randomized controlled trial comparing standard prophylactic dose versus intermediate dose enoxapar... | {
"P": [
"adults with severe COVID - 19",
"adults who were hospitalized with COVID - 19 and admitted to an intensive care unit ( ICU ) and / or had laboratory evidence of coagulopathy"
],
"I": [
"intermediate dose enoxaparin",
"intermediate weight - adjusted dose enoxaparin"
],
"C": [
"Sta... |
Title : Intravenous immunoglobulin for treatment of mild - to - moderate Alzheimer ' s disease : a phase 2 , randomised , double - blind , placebo - controlled , dose - finding trial . METHODS : We did a multicentre , placebo - controlled phase 2 trial at seven sites in the USA and five in Germany . Participants with p... | {
"P": [
"Participants with probable Alzheimer ' s disease aged 50 - 85 years"
],
"I": [
"Intravenous immunoglobulin",
"02",
"05",
"08 g intravenous immunoglobulin",
"01",
"025",
"04 g / kg"
],
"C": [
"placebo"
],
"O": [
"plasma amyloid ? ( A? ) ( 1 - 40 )"
]
} |
Title : Atomoxetine augmentation of cholinesterase inhibitor therapy in patients with Alzheimer disease : 6 - month , randomized , double - blind , placebo - controlled , parallel - trial study . METHODS : A randomized , double - blind , placebo ( PLA ) - controlled , parallel - groups study , starting with a 5 - 33 - ... | {
"P": [
"patients with Alzheimer disease",
"Male or female patients , aged 55 years and older , with mild - to - moderate Alzheimer disease ( Mini - Mental State Examination score between 10 and 26 ) at baseline"
],
"I": [
"Atomoxetine",
"cholinesterase inhibitor therapy",
"ATX",
"PLA",
... |
Title : Assessing the cost - effectiveness of the rivastigmine transdermal patch for Alzheimer ' s disease in the UK using MMSE - and ADL - based models . METHODS : Incremental costs and Quality Adjusted Life Years ( QALYs ) associated with rivastigmine patch and capsule treatment versus best supportive care ( BSC ) we... | {
"P": [],
"I": [
"the rivastigmine transdermal patch",
"rivastigmine patch",
"capsule treatment",
"capsules"
],
"C": [
"best supportive care ( BSC )",
"placebo"
],
"O": [
"Incremental costs",
"Quality Adjusted Life Years ( QALYs )",
"Mini - Mental State Examination ( MMS... |
Title : Comparison of losartan and amlodipine effects on the outcomes of patient with COVID - 19 and primary hypertension : A randomised clinical trial . METHODS : In this randomised clinical trial , hospitalised patients with COVID - 19 and primary HTN were enrolled in the study . One arm received losartan , 25 mg , t... | {
"P": [
"patient with COVID - 19 and primary hypertension",
"hospitalised patients with COVID - 19 and primary HTN"
],
"I": [
"losartan",
"amlodipine"
],
"C": [],
"O": [
"compare 30 - day mortality rate",
"length of hospital stay"
]
} |
Title : Efficacy of Tocilizumab in Patients Hospitalized with Covid - 19 . METHODS : We performed a randomized , double - blind , placebo - controlled trial involving patients with confirmed severe acute respiratory syndrome coronavirus 2 ( SARS - CoV - 2 ) infection , hyperinflammatory states , and at least two of the... | {
"P": [
"Patients Hospitalized with Covid - 19",
"patients with confirmed severe acute respiratory syndrome coronavirus 2 ( SARS - CoV - 2 ) infection , hyperinflammatory states , and at least two of the following signs : fever ( body temperature > 38 C ) , pulmonary infiltrates , or the need for supplementa... |
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