Dataset Viewer
Auto-converted to Parquet Duplicate
nctId
large_stringlengths
11
11
briefTitle
large_stringlengths
34
291
officialTitle
large_stringlengths
34
277
acronym
large_stringlengths
3
14
organization
large_stringlengths
7
89
overallStatus
large_stringclasses
8 values
studyType
large_stringclasses
2 values
phases
large_stringclasses
9 values
enrollmentCount
int64
0
10k
leadSponsor
large_stringlengths
7
89
sponsorClass
large_stringclasses
4 values
collaborators
large_stringlengths
2
271
conditions
large_stringlengths
12
342
interventions
large_stringlengths
2
149
briefSummary
large_stringlengths
82
3.57k
sex
large_stringclasses
3 values
minimumAge
large_stringclasses
18 values
maximumAge
large_stringclasses
18 values
healthyVolunteers
bool
2 classes
startDate
large_stringlengths
7
10
completionDate
large_stringlengths
7
10
primaryCompletionDate
large_stringlengths
7
10
firstPostedDate
large_stringdate
1999-11-04 00:00:00
2026-05-01 00:00:00
lastUpdatePostedDate
large_stringdate
2006-01-18 00:00:00
2026-05-13 00:00:00
locations
large_stringlengths
2
13.1k
hasResults
bool
2 classes
url
large_stringlengths
44
44
scrapedAt
large_stringlengths
24
24
NCT01213784
Optimized Glycemic Control in Heart Failure Patients With DM2:"Effect on Left Ventricular Function and Skeletal Muscle"
Optimized Glycemic Control in Type 2 Diabetics With Heart Failure:"Effect on Left Ventricular Function and Skeletal Muscle"
HFDM
University of Aarhus
COMPLETED
INTERVENTIONAL
["PHASE2"]
40
University of Aarhus
OTHER
["The Danish Diabetes Association"]
["Type 2 Diabetes", "Heart Failure"]
["OTHER: all antidiabetic drugs will be appliable"]
The investigators wish to investigate wether a more strict diabetic control improves cardiac function, muscle strength, exercise capacity and decreases symptoms. The investigators hypothesis is that improving the glycemic control in suboptimized diabetics with heart failure will improve cardiac performance, muscle str...
ALL
18 Years
90 Years
false
2010-09
2012-11
2012-11
2010-10-04
2015-03-06
[{"facility": "Dept. of cardiology, Aarhus university hospital Skejby", "city": "Aarhus", "state": "Central Jutland", "country": "Denmark"}]
false
https://clinicaltrials.gov/study/NCT01213784
2026-05-14T17:51:03.369Z
NCT03060538
A Multiple Ascending Dose Study to Evaluate Safety and Tolerability of BFKB8488A in Participants With Type 2 Diabetes Mellitus and Participants With Non-Alcoholic Fatty Liver Disease
A Phase Ib, Randomized, Blinded, Placebo-Controlled, Multiple Ascending-Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous BFKB8488A in Patients With Type 2 Diabetes Mellitus and Patients With Non-Alcoholic Fatty Liver Disease
null
Genentech, Inc.
COMPLETED
INTERVENTIONAL
["PHASE1"]
154
Genentech, Inc.
INDUSTRY
[]
["Diabetes Mellitus, Type 2", "Non-Alcoholic Fatty Liver Disease"]
["DRUG: BFKB8488A", "OTHER: Placebo"]
This is a Phase Ib, randomized, blinded, placebo-controlled, multiple ascending-dose study of the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) effects of BFKB8488A in participants with Type 2 diabetes mellitus (T2DM) and participants with non-alcoholic fatty liver disease(NAFLD). A maximum of ap...
ALL
18 Years
75 Years
false
2017-03-05
2019-12-13
2019-12-13
2017-02-23
2020-03-27
[{"facility": "Pinnacle Research Group Cullman", "city": "Anniston", "state": "Alabama", "country": "United States"}, {"facility": "Pinnacle Research Group; Llc, Central", "city": "Anniston", "state": "Alabama", "country": "United States"}, {"facility": "Southern California Research Center, Inc.", "city": "Coronado", "...
false
https://clinicaltrials.gov/study/NCT03060538
2026-05-14T17:51:03.463Z
NCT02675855
GrafixPRIME® for the Treatment of Chronic Diabetic Foot Ulcers
A Multicenter, Randomized, Single-Blind Study Comparing the Efficacy of GrafixPRIME® to Active Comparator for the Treatment of Chronic Diabetic Foot Ulcers
null
Osiris Therapeutics
COMPLETED
INTERVENTIONAL
["PHASE4"]
75
Osiris Therapeutics
INDUSTRY
[]
["Foot Ulcer, Diabetic"]
["OTHER: GrafixPRIME®", "PROCEDURE: Dressing Application", "DEVICE: Off-loading (walking boot)"]
The objective of the study is to compare the efficacy of weekly GrafixPRIME® administration to an Active Comparator in patients with chronic DFUs in a randomized, single-blind study.
ALL
18 Years
80 Years
false
2016-01
2017-07
2017-07
2016-02-05
2017-07-17
[{"facility": null, "city": "Arizona City", "state": "Arizona", "country": "United States"}, {"facility": null, "city": "California City", "state": "California", "country": "United States"}, {"facility": null, "city": "New Mexico", "state": "New Mexico", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT02675855
2026-05-14T17:51:03.504Z
NCT01185743
Antipsychotics and Gene Expression in Soft Tissues
Effect of Atypical Antipsychotics on Gene Expression in Soft Tissues of Healthy Subjects - A Placebo Controlled Randomised Pilot Study
null
Medical University of Vienna
COMPLETED
INTERVENTIONAL
["PHASE4"]
16
Medical University of Vienna
OTHER
[]
["Schizophrenia", "Diabetes"]
["DRUG: olanzapine", "DRUG: ziprasidone", "DRUG: placebo"]
Schizophrenia is a severe chronic and disabling mental disorder and is associated with a significant reduction in life expectancy. Atypical antipsychotic treatment compliance may be jeopardized because of drug induced weight gain and abnormalities in carbohydrate and lipid metabolism. Aim: to gain data on drug related...
MALE
18 Years
45 Years
true
2010-07
2017-01-01
2017-01-01
2010-08-20
2017-03-23
[{"facility": "Medical University of Vienna", "city": "Vienna", "state": "State of Vienna", "country": "Austria"}]
false
https://clinicaltrials.gov/study/NCT01185743
2026-05-14T17:51:03.591Z
NCT01827735
Regulatory T Cells in Type 1 Diabetes Patients Treated With IL-2
Adaptive Study of IL-2 Dose on Regulatory T Cells in Type 1 Diabetes (DILT1D)
DILT1D
Cambridge University Hospitals NHS Foundation Trust
COMPLETED
INTERVENTIONAL
["PHASE1", "PHASE2"]
40
Cambridge University Hospitals NHS Foundation Trust
OTHER
["University of Cambridge", "Juvenile Diabetes Research Foundation", "National Institute for Health Research, United Kingdom", "Wellcome Trust"]
["Type 1 Diabetes"]
["DRUG: Aldesleukin (Proleukin)"]
Type 1 diabetes is the most common severe chronic autoimmune disease worldwide and is caused by the autoimmune (loss of self tolerance) mediated destruction of the insulin producing pancreatic beta cells thus leading to insulin deficiency and development of hyperglycaemia. Currently, medical management of type 1 diabet...
ALL
18 Years
50 Years
false
2013-03
2014-05
2014-05
2013-04-10
2015-06-23
[{"facility": "Wellcome Trust Clinical Research Facility, Addenbrooke's Hospital", "city": "Cambridge", "state": null, "country": "United Kingdom"}]
false
https://clinicaltrials.gov/study/NCT01827735
2026-05-14T17:51:03.641Z
NCT00437008
Effects of Benfotiamine and AGE on Endothelial Function in People With Diabetes
Acute Effects of a Low-AGE vs. High-AGE Meal on Postprandial Endothelial Function in People With Type 2 Diabetes Mellitus. Protective Effects of Benfotiamine
AGE-Benfo
Ruhr University of Bochum
COMPLETED
INTERVENTIONAL
["PHASE4"]
21
Ruhr University of Bochum
OTHER
[]
["Endothelial Dysfunction", "Type 2 Diabetes Mellitus"]
["DRUG: Benfotiamine 1050mg, 3 days", "BEHAVIORAL: high-AGE vs. low-AGE meal"]
The purpose of the study is to determine whether there are differences in postprandial endothelial function following a high-AGE(Advanced Glycation End-products) meal vs. a low-AGE meal. We also intend to investigate if the therapy with 1050mg Benfotiamine for 3 days protects against the postulated deterioration of end...
ALL
35 Years
70 Years
false
2004-11
2006-01
null
2007-02-19
2007-02-19
[{"facility": "Heart and Diabetes Center NRW", "city": "Bad Oeynhausen", "state": null, "country": "Germany"}]
false
https://clinicaltrials.gov/study/NCT00437008
2026-05-14T17:51:03.685Z
NCT05452525
Pharmacokinetics and Safety/Tolerability Profile of CKD-379
A Randomized, Open-label, Single Dose, 3-period, 6-treatment, Crossover Study to Compare the Pharmacokinetics and Safety/Tolerability of CKD-379 and Coadministration of D759, D745 and D150 in Healthy Subjects
null
Chong Kun Dang Pharmaceutical
COMPLETED
INTERVENTIONAL
["PHASE1"]
24
Chong Kun Dang Pharmaceutical
INDUSTRY
[]
["Type II Diabetes Mellitus"]
["DRUG: CKD-379 I", "DRUG: CKD-379 II", "DRUG: D759+D745+D150"]
A study to compare the pharmacokinetics and safety/tolerability between CKD-379 tablet and D759, D745, D150 combination
ALL
19 Years
50 Years
true
2022-07-26
2022-09-21
2022-08-27
2022-07-11
2022-10-18
[{"facility": "Seoul National University Hospital", "city": "Seoul", "state": "Jongno-gu", "country": "South Korea"}]
false
https://clinicaltrials.gov/study/NCT05452525
2026-05-14T17:51:03.718Z
NCT01387425
Efficacy And Safety Of Smoking Cessation With Varenicline Tartrate In Diabetic Smokers: (DIASMOKE)
Efficacy And Safety Of Smoking Cessation With Varenicline Tartrate In Diabetic Smokers: A Double-Blind, Placebo-Controlled, Randomized, Trial
DIASMOKE
Universita degli Studi di Catania
COMPLETED
INTERVENTIONAL
["NA"]
300
Universita degli Studi di Catania
OTHER
[]
["Smoking Cessation", "Diabetes"]
["DRUG: varenicline", "DRUG: placebo tablet is made of lactose"]
Objectives This protocol is intended to provide information regarding the efficacy and safety of the nicotine partial agonist varenicline tartrate, at a dose of 1 mg twice daily, for smoking cessation in diabetic subjects who smoke. Given that a better understanding of predictors of smoking cessation can be useful in ...
ALL
18 Years
75 Years
false
2011-06
null
2015-12
2011-07-04
2015-12-02
[{"facility": "Centro per la Prevenzione e Cura del Tabagimso", "city": "Catania", "state": "Italy", "country": "Italy"}, {"facility": "Centro per la Prevenzione eCura del Tabagimso", "city": "Catania", "state": "Italy", "country": "Italy"}]
false
https://clinicaltrials.gov/study/NCT01387425
2026-05-14T17:51:03.761Z
NCT06069076
Diagnostic Value of Serum Cathepsin S and Chromogranin A in DKD
Diagnostic Value of Serum Cathepsin S and Chromogranin A in Diabetic Kidney Disease
null
Assiut University
NOT_YET_RECRUITING
OBSERVATIONAL
[]
92
Assiut University
OTHER
[]
["Diabetic Kidney Disease"]
["DIAGNOSTIC_TEST: cathepsin S and chromogranin A"]
1. Evulate the diagnostic value of serum cathepsin S and chromogranin A for Diabetic kidney disease. 2. To correlate the levels of serum Cathepsin S and chromogranin A with HbA1c and eGFR in type 2 diabetic patients based on urinary Albumin- Creatinine Ratio.
ALL
20 Years
80 Years
true
2023-11-01
2026-10-01
2025-10-01
2023-10-05
2023-10-13
[]
false
https://clinicaltrials.gov/study/NCT06069076
2026-05-14T17:51:03.813Z
NCT04841668
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly
SmartAge
Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
COMPLETED
OBSERVATIONAL
[]
50
Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
OTHER
[]
["Type 2 Diabetes Mellitus"]
["DRUG: Metformin"]
Cognitive disorders increase with age and in the presence of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). In addition, digestive disorders, changes in dietary pattern and decreased activity negatively influence the microbiome. The hypothesis is that pharmacological intervention with metformin will modif...
ALL
65 Years
80 Years
false
2021-04-10
2024-12-03
2024-12-03
2021-04-12
2026-03-31
[{"facility": "Institut d'Investigació Biomèdica de Girona (IDIBGI)", "city": "Girona", "state": "Girona", "country": "Spain"}]
false
https://clinicaltrials.gov/study/NCT04841668
2026-05-14T17:51:03.861Z
NCT03353376
Group Versus Individual Care in Diabetes Clinic
Group Versus Individual Care in Patients With Long Standing Type 1 and Type 2 Diabetes: Non Inferiority in a One Year Prospective Study in a Tertiary Diabetes Clinic
null
Rabin Medical Center
COMPLETED
INTERVENTIONAL
["NA"]
60
Rabin Medical Center
OTHER
[]
["Diabetes Mellitus", "Group Meetings"]
["BEHAVIORAL: group care with Empowerment model"]
In this prospective, randomized, non blinded, one center (University hospital) trial, 60 patients (28 with type 1 and 32 with type 2 diabetes) with a mean duration of diabetes of 22.5 ± 11.7 years were randomly assigned to group (6 patients per group) or individual usual care for one year. Primary end-point included ch...
ALL
18 Years
null
false
2010-09-13
2014-01-02
2014-01-02
2017-11-27
2017-11-27
[]
false
https://clinicaltrials.gov/study/NCT03353376
2026-05-14T17:51:03.905Z
NCT04978974
Implications of Stress Management Program
Stress, Coping Strategies and Quality of Life Among Patients With Chronic Conditions: Implications of Stress Management Program
null
University of Gujrat
COMPLETED
INTERVENTIONAL
["NA"]
110
University of Gujrat
OTHER
[]
["Chronic Conditions, Multiple"]
["BEHAVIORAL: Stress Management Program"]
Previous studies indicated that patients with diabetes mellitus and hypertension had higher level of perceived stress, used maladaptive coping strategies and poor health-related quality of life. Therefore, stress management program was applied to reduce their perceived stress, improve their coping strategies, improve t...
ALL
31 Years
60 Years
false
2019-05-03
2020-12-29
2020-01-03
2021-07-27
2021-07-27
[{"facility": "Jhelum Poly Clinic", "city": "Jhelum", "state": "Punjab Province", "country": "Pakistan"}]
false
https://clinicaltrials.gov/study/NCT04978974
2026-05-14T17:51:03.953Z
NCT00283218
A Comparison of Pharmacodynamics and Pharmacokinetics of Insulin Aspart, Biphasic Insulin Aspart 30, 50 and 70.
A Comparison of Pharmacodynamics and Pharmacokinetics of Insulin Aspart, Biphasic Insulin Aspart 30, 50 and 70. - A Randomised, Quadruple Cross-Over Trial
null
University of Aarhus
COMPLETED
INTERVENTIONAL
["NA"]
24
University of Aarhus
OTHER
["Novo Nordisk A/S"]
["Type 1 Diabetes"]
["DRUG: NovoRapid, NovoMix 30, Bifasisk Insulin Aspart 50, BIAsp70"]
The hypothesis is that an optimal formulation of fast acting and intermediary acting insulin analogues will improve post prandial glycaemic control in patients with type 1 diabetes. OBJECTIVE: The objective is to describe pharmacodynamic (PD) and pharmacokinetic (PK) profiles of Insulin Aspart (IAsp), Biphasic Insuli...
ALL
18 Years
null
false
2006-01
2006-08
null
2006-01-27
2006-08-08
[{"facility": "Dept of Medicine M, Aarhus University Hospital, Nørrebrogade 44", "city": "Aarhus", "state": "C", "country": "Denmark"}]
false
https://clinicaltrials.gov/study/NCT00283218
2026-05-14T17:51:04.004Z
NCT03819790
The Effect of Soliqua on Glucose Variability in Type 2 Patients Among South Asians
Variability of Glucose Assessed in a Randomized Trial Comparing the Initiation of A Treatment Approach With Biosimilar Basal Insulin Analog Or a Titratable iGlarLixi combinatioN in Type 2 Diabetes Among South Asian Subjects (VARIATION 2 SA Trial)
VARIATION 2 SA
LMC Diabetes & Endocrinology Ltd.
COMPLETED
INTERVENTIONAL
["PHASE4"]
119
LMC Diabetes & Endocrinology Ltd.
OTHER
[]
["Diabetes Mellitus, Type 2"]
["DRUG: Basal insulin glargine and lixisenatide", "DRUG: Basal insulin Basaglar/Lantus + gliclazide MR", "DRUG: Metformin"]
The overall objective of this study is to compare the effects of Soliqua, a titratable combination of insulin and GLP-1 receptor agonist in a single pen versus Glargine U100 insulin (Basaglar or Lantus) and gliclazide MR, both added to metformin, on measures of glucose variability using masked CGM data among people of ...
ALL
18 Years
80 Years
false
2018-10-02
2019-11-19
2019-11-19
2019-01-29
2021-02-25
[{"facility": "LMC Brampton", "city": "Brampton", "state": "Ontario", "country": "Canada"}, {"facility": "LMC Etobicoke", "city": "Etobicoke", "state": "Ontario", "country": "Canada"}, {"facility": "LMC Scarborough", "city": "Toronto", "state": "Ontario", "country": "Canada"}]
false
https://clinicaltrials.gov/study/NCT03819790
2026-05-14T17:51:04.056Z
NCT07442110
This Observational Study Evaluates the Clinical Outcomes of Patients With Diabetes Who Utilize a Specialized Dietary Supplements for Foot Ulcer Healing. The Study Documents the Rate of Complete Wound Closure and the Prevention of Lower Extremity Amputations in a Real-world, At-home Setting.
Observational Study of a Specialized Dietary Supplements on the Healing of Diabetic Foot Ulcers and Prevention of Amputations
null
Amar Zireg
COMPLETED
OBSERVATIONAL
[]
35
Amar h Zireg
OTHER
["Self funded"]
["Limb Salvage", "Diabetes Complication", "Dietary Supplements", "Healed Ulcer", "Wound Closure", "At Home Setting", "Diabetes Mellitus, Type 1, Type 2", "Wound Healing", "Diabetic Foot Ulcer"]
["DIETARY_SUPPLEMENT: Diabetic foot ulcer treatment by dietary supplements"]
This observational study evaluates the clinical outcomes of patients with diabetes who utilize a specialized dietary supplements for foot ulcer healing. The study documents the rate of complete wound closure and the prevention of lower extremity amputations in a real-world, at-home setting.
ALL
25 Years
null
false
2025-07-05
2025-09-30
2025-09-02
2026-03-02
2026-03-04
[{"facility": "Amar hocine Zireg", "city": "Bordj Bou Arreridj", "state": "Wilaya de Bordj Bou Arréridj", "country": "Algeria"}]
false
https://clinicaltrials.gov/study/NCT07442110
2026-05-14T17:51:04.097Z
NCT00643110
Milk as Treatment for Hypoglycemia
Milk as Treatment for Hypoglycemia
null
Creighton University
WITHDRAWN
INTERVENTIONAL
["NA"]
0
Creighton University
OTHER
[]
["Type 1 Diabetes"]
["DRUG: D50 glucose"]
Test hypothesis that milk can raise blood sugars as well as orange juice or glucose tablets without raising blood sugars too much the way that orange juice or glucose tablets sometimes do.
ALL
19 Years
null
true
2008-04
2009-01
2009-01
2008-03-26
2015-03-25
[{"facility": "Creighton Diabetes Center", "city": "Omaha", "state": "Nebraska", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT00643110
2026-05-14T17:51:04.139Z
NCT05626413
Cardiovascular Disease in Patients With Diabetes: The Silesia Diabetes-Heart Project
Cardiovascular Disease and Diabetes in Silesian Patients
null
Medical University of Silesia
UNKNOWN
OBSERVATIONAL
[]
4,000
Medical University of Silesia
OTHER
["Silesian University of Technology", "Liverpool Heart and Chest Hospital NHS Foundation Trust"]
["Diabetes Mellitus"]
[]
The project is an observational one which undertakes different, easy to obtain in everyday clinical practice, demographical, laboratory and clinical parameters of patients with diabetes in Silesian Region in Poland to predict cardiovascular disease, cardiovascular events and neuropathy using machine learning approach.
ALL
18 Years
null
false
2015-01-01
2026-01-31
2025-12-31
2022-11-23
2024-04-10
[{"facility": "Department of Internal Diseases, Diabetology and Nephrology", "city": "Zabrze", "state": null, "country": "Poland"}]
false
https://clinicaltrials.gov/study/NCT05626413
2026-05-14T17:51:04.171Z
NCT04583813
Empagliflozin and Atrial Fibrillation Treatment
Efficacy of Empagliflozin in Patients With Heart Failure and Atrial Fibrillation
EMPA-AF
Miulli General Hospital
UNKNOWN
INTERVENTIONAL
["PHASE4"]
400
Miulli General Hospital
OTHER
[]
["Atrial Fibrillation", "Heart Failure", "Obesity", "Diabetes Mellitus"]
["DRUG: Empagliflozin", "OTHER: Placebo"]
The primary purpose of this trial is to evaluate the impact of empagliflozin, as compared with placebo, in patients with diabetes mellitus or overweight, heart failure and atrial fibrillation.
ALL
18 Years
80 Years
false
2021-09
2024-04
2024-01
2020-10-12
2021-04-02
[{"facility": "Miulli General Hospital", "city": "Acquaviva delle Fonti", "state": "Bari", "country": "Italy"}]
false
https://clinicaltrials.gov/study/NCT04583813
2026-05-14T17:51:04.208Z
NCT03825926
Early Screening of Gestational Diabetes Mellitus and Prospective Cohort Study of Postpartum Follow-up
Early Screening of Gestational Diabetes Mellitus and Prospective Cohort Study of Postpartum Follow-up
null
Fifth Affiliated Hospital, Sun Yat-Sen University
UNKNOWN
OBSERVATIONAL
[]
600
Fifth Affiliated Hospital, Sun Yat-Sen University
OTHER
[]
["Gestational Diabetes Mellitus"]
[]
Extraction of whole blood from 10 to 15ml at 24 weeks before pregnancy test, with a view to early detection of GDM, provides evidence for early intervention to improve maternal pregnancy outcomes and metabolic abnormalities.
FEMALE
18 Years
50 Years
true
2019-06-01
2025-12-01
2025-06-01
2019-02-01
2020-03-31
[{"facility": "the Fifth Affiliated Hospital of Sun Yat-sen University of Gynaecology and Obstetrics", "city": "Zhuhai", "state": "Guangdong", "country": "China"}]
false
https://clinicaltrials.gov/study/NCT03825926
2026-05-14T17:51:04.248Z
NCT01426685
Prognosis of Type 2 Diabetic Patients
Prediction of Cardiovascular Events in Type 2 Diabetic Patients With Coronary Artery Disease- Application of Novel Risk Markers and Technology
ARTEMIS
University of Oulu
UNKNOWN
OBSERVATIONAL
[]
1,880
University of Oulu
OTHER
["The Finnish Funding Agency for Technology and Innovation"]
["Cardiovascular Risk Assessment"]
[]
The study will include 1200 patients with type 2 diabetes and angiographically documented coronary artery disease and 600 matched non-diabetic patients without type 2 diabetes. Extensive traditional and novel risk marker tests are performed for the patients and they will be followed-up for 5 years. Sudden cardiac death...
ALL
18 Years
75 Years
false
2007-08
2019-06
2019-06
2011-08-31
2019-04-19
[{"facility": "University of Oulu", "city": "Oulu", "state": null, "country": "Finland"}]
false
https://clinicaltrials.gov/study/NCT01426685
2026-05-14T17:51:04.291Z
NCT07395050
Autologous CD6-CAR Treg Cells for Patients With Stage 3 Type 1 Diabetes
A Pilot Study to Evaluate the Safety, Tolerability, and Feasibility of Autologous Anti-CD6 Chimeric Antigen Receptor T Regulatory Cells (CD6-CAR Tregs) in Patients With Stage 3 Type 1 Diabetes
null
City of Hope Medical Center
NOT_YET_RECRUITING
INTERVENTIONAL
["EARLY_PHASE1"]
6
City of Hope Medical Center
OTHER
["National Cancer Institute (NCI)"]
["Stage 3 Type 1 Diabetes"]
["DRUG: AutoCD6-CAR Treg cells"]
Type 1 diabetes (T1D) is a persistent and gradually increasing genetic autoimmune disease requiring life-long management. The disease commonly impacts children. However, a quarter of cases are diagnosed in adults. The pancreatic islet beta-cells are responsible for producing insulin, a peptide hormone that is involved ...
ALL
18 Years
35 Years
false
2026-06-01
2026-09-14
2026-09-14
2026-02-09
2026-05-13
[{"facility": "City of Hope Medical Center", "city": "Duarte", "state": "California", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT07395050
2026-05-14T17:51:04.321Z
NCT03457168
Treatment of Hypertension During Sleep
A Prospective, Randomized, Open-label Clinical Trial on the Effects of Intensive Versus Conventional Control of Ambulatory-determined Asleep Systolic Blood Pressure Mean on Cardiovascular, Metabolic, and Renal Disease Risks
THADEUS
University of Vigo
RECRUITING
INTERVENTIONAL
["NA"]
5,320
University of Vigo
OTHER
[]
["Hypertension", "Hypertension, Systolic"]
["PROCEDURE: Treatment of elevated asleep SBP mean"]
On the basis of new evidence on the relationship between achieved office blood pressure (BP) measurements (OBPM) and the risk of cardiovascular disease (CVD) morbidity and mortality documented in the SPRINT trial, the recent 2017 guidelines of the American College of Cardiology (ACC) and the American Heart Association ...
ALL
18 Years
null
false
2019-02-01
2032-12-31
2031-12-31
2018-03-07
2024-12-06
[{"facility": "Complexo Hospitalario Universitario de Ourense", "city": "Ourense", "state": "Orense", "country": "Spain"}, {"facility": "CS A Estrada", "city": "A Estrada", "state": "Pontevedra", "country": "Spain"}, {"facility": "CS Panxón", "city": "Nigrán", "state": "Pontevedra", "country": "Spain"}, {"facility": "C...
false
https://clinicaltrials.gov/study/NCT03457168
2026-05-14T17:51:04.353Z
NCT06683391
Updating Preventive and Treatment Guidelines for Hypoglycemia in Individuals Living With Type 1 Diabetes
Updating pReventive and Treatment guidelinEs for Mild hypOglycemia in Individuals Living With Type 1 Diabetes During the erA of Continuous gLucose Monitoring: The REMODAL Trial
REMODAL
Institut de Recherches Cliniques de Montreal
RECRUITING
INTERVENTIONAL
["NA"]
32
Institut de Recherches Cliniques de Montreal
OTHER
[]
["Type 1 Diabetes"]
["BEHAVIORAL: Oral Carbohydrate (CHO) Administration for Hypoglycemia Prevention and Treatment"]
The REMODAL trial is a randomized crossover study aiming to update treatment guidelines for mild hypoglycemia in people with Type 1 diabetes using continuous glucose monitoring (CGM) technology. The study will assess whether treating mild hypoglycemia proactively (at a glucose threshold of 5.0 mmol/L) with lower doses ...
ALL
18 Years
null
false
2025-02-06
2027-12-31
2026-12-31
2024-11-12
2025-02-25
[{"facility": "Institut de recherches cliniques de Montréal", "city": "Montreal", "state": "Quebec", "country": "Canada"}, {"facility": "Montreal Clinical Research Institute", "city": "Montreal", "state": "Quebec", "country": "Canada"}]
false
https://clinicaltrials.gov/study/NCT06683391
2026-05-14T17:51:04.389Z
NCT03915990
Middle Cerebral and Umbilical Arteries Doppler Indices in the Prediction of Adverse Neonatal Outcome Among Diabetic Pregnant Women
Middle Cerebral and Umbilical Arteries Doppler Indices in Pregestational Diabetic Versus Normal Pregnancies and Their Values in Predicting Adverse Neonatal Outcome
null
Cairo University
UNKNOWN
INTERVENTIONAL
["NA"]
120
Cairo University
OTHER
[]
["Diabetes Mellitus, Type 1"]
["DIAGNOSTIC_TEST: umbilical and middle cerebral artery Doppler"]
120 patients will be included and divided into two groups; Control group that will include 60 healthy pregnant women and Study group that will include 60 pregestational diabetic pregnant patients which furtherly will be subdivided into two groups according to HbA1C levels namely; controlled diabetics ( will include 30 ...
FEMALE
18 Years
40 Years
false
2019-07-01
2020-12
2020-12
2019-04-16
2020-11-10
[{"facility": "kasr elainy hospital (Faculty of Medicine - Cairo University)", "city": "Cairo", "state": null, "country": "Egypt"}]
false
https://clinicaltrials.gov/study/NCT03915990
2026-05-14T17:51:04.424Z
NCT00476710
Effects of Colesevelam HCl On Bile Acid Kinetics
Effects of Colesevelam HCl On Bile Acid Pools And Kinetic Parameters in Normal Subjects, Subjects With Impaired Glucose Tolerance, And Subjects With Type 2 Diabetes Mellitus
null
KineMed
COMPLETED
OBSERVATIONAL
[]
36
KineMed
INDUSTRY
["Daiichi Sankyo", "University Medical Center Groningen", "Diabetes & Glandular Disease Research Associates"]
["Type 2 Diabetes Mellitus", "Impaired Glucose Tolerance"]
["DRUG: Colesevelam HCl"]
This project will compare the amount of bile acids and their kinetics in overweight and obese people with normal glucose metabolism, impaired glucose tolerance and frank type 2 diabetes. We hypothesize that bile acids will behave differently in these groups. We will also explore the effects of Colesevelam HCl, a medici...
ALL
40 Years
60 Years
true
2007-05
2009-04
2009-04
2007-05-22
2015-04-01
[{"facility": "Diabetes & Glandular Disease Research Associates, Inc.", "city": "San Antonio", "state": "Texas", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT00476710
2026-05-14T17:51:04.462Z
NCT01659697
Diabetes Prevention in Prediabetic Patients
Diabetes Prevention in Patients Aged 25-55 From Ethiopian Origin With Prediabetes: Evaluation of Feasibility and Efficacy of Intensive or Less Intensive Lifestyle Intervention
DPEP
Meir Medical Center
UNKNOWN
OBSERVATIONAL
[]
200
Meir Medical Center
OTHER
["Clalit Health Services"]
["Ethnic Group", "Young Adults", "Prediabetes", "Community Health Services"]
["BEHAVIORAL: intensive lifestyle counseling"]
This study will evaluate the feasibility and efficacy of two interventions of lifestyle ( intensive and less intensive) to prevent diabetes in patients from Ethiopian origin, aged 25 to 55 years old with prediabetes living in Israel and insured by Clalit Health Services in the Central district, using resources existing...
ALL
25 Years
55 Years
false
2012-08
2015-07
2014-12
2012-08-08
2012-08-08
[{"facility": "Central district Clalit Health Services", "city": "Rishon LeZiyyon", "state": null, "country": "Israel"}]
false
https://clinicaltrials.gov/study/NCT01659697
2026-05-14T17:51:04.605Z
NCT00974090
Efficacy and Safety Study of MP-513 in Combination With Sulfonylurea in Patients With Type 2 Diabetes
A Phase III Study of MP-513 in Combination With Sulfonylurea in Japanese Patients With Type 2 Diabetes Mellitus
null
Tanabe Pharma Corporation
COMPLETED
INTERVENTIONAL
["PHASE3"]
194
Tanabe Pharma Corporation
INDUSTRY
[]
["Type 2 Diabetes Mellitus"]
["DRUG: Placebo / Teneli (Teneligliptin) + SU (Sulfonylurea)", "DRUG: Teneli / Teneli + SU"]
The purpose of this study is to evaluate the safety and efficacy of MP-513 (Teneligliptin) in combination with Sulfonylurea in patients with type 2 Diabetes for 12 weeks administration and to evaluate the safety and efficacy of MP-513 in combination with Sulfonylurea with an extension treatment for up to 52 weeks.
ALL
20 Years
75 Years
false
2009-09
2011-03
2011-03
2009-09-10
2026-01-05
[{"facility": null, "city": "Sapporo", "state": "Hokkaido", "country": "Japan"}]
true
https://clinicaltrials.gov/study/NCT00974090
2026-05-14T17:51:04.688Z
NCT01583790
Factors Influencing the Positive Outcome of Bariatric Surgery for Morbidly Obese Patients
A Prospective Trial for Laparoscopic Adjustable Gastric Banding in Morbidly Obese Patients: Report on Weight Loss, Metabolic Changes and Quality of Life
null
Assuta Hospital Systems
UNKNOWN
OBSERVATIONAL
[]
2,000
Assuta Hospital Systems
OTHER
[]
["Morbid Obesity", "Diabetes", "Hypertension"]
[]
The purpose of this study is to report data with patients after bariatric surgery.
ALL
14 Years
65 Years
false
2012-01
2020-01
2019-01
2012-04-24
2018-01-25
[{"facility": "Assuta Medical Center", "city": "Tel Aviv", "state": null, "country": "Israel"}]
false
https://clinicaltrials.gov/study/NCT01583790
2026-05-14T17:51:04.712Z
NCT00746460
The Healthy Options Feasibility Study
The Effectiveness of CVD Risk Profiles When Used by Allied Health Care Providers (HCP) Within a "Groupe de Médecine de Famille": The Healthy Options Feasibility Study.
null
McGill University
COMPLETED
INTERVENTIONAL
["NA"]
50
McGill University
OTHER
["Pfizer"]
["Obesity", "Sedentary Lifestyle", "Dyslipidemia", "Hypertension", "Cigarette Smoking", "Diabetes"]
["BEHAVIORAL: CVD risk profile"]
The investigators hypothesize that having health care providers other than physicians within a "Groupe de Médecine de Famille" conduct cardiovascular risk assessments and teach lifestyle interventions to primary prevention patients will increase the likelihood that patients will adopt and maintain healthy lifestyles. T...
ALL
30 Years
79 Years
false
2008-06
2009-10
2009-04
2008-09-04
2014-01-14
[{"facility": "McGill Cardiovascular Health Improvement Program", "city": "Montreal", "state": "Quebec", "country": "Canada"}]
false
https://clinicaltrials.gov/study/NCT00746460
2026-05-14T17:51:04.762Z
NCT05463744
A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy
A Phase 3, Multicenter, Randomized, Parallel-Design, Open-Label Study to Evaluate the Efficacy and Safety of LY3209590 as a Weekly Basal Insulin Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy
QWINT-5
Eli Lilly and Company
COMPLETED
INTERVENTIONAL
["PHASE3"]
692
Eli Lilly and Company
INDUSTRY
[]
["Type 1 Diabetes", "Diabetes"]
["DRUG: Insulin Efsitora Alfa", "DRUG: Insulin Degludec"]
The main purpose of this study is to measure the safety and efficacy of insulin efsitora alfa (LY3209590) compared with insulin degludec in participants with type 1 diabetes treated with multiple daily injection therapy.
ALL
18 Years
null
false
2022-08-12
2024-05-07
2024-05-07
2022-07-19
2025-06-24
[{"facility": "John Muir Physician Network Research Center", "city": "Concord", "state": "California", "country": "United States"}, {"facility": "Valley Research", "city": "Fresno", "state": "California", "country": "United States"}, {"facility": "Catalina Research Institute, LLC", "city": "Montclair", "state": "Califo...
true
https://clinicaltrials.gov/study/NCT05463744
2026-05-14T17:51:04.834Z
NCT03331432
Effects of Dietary Supplement Tauroursodeoxycholic Acid on Vascular Function
Targeting Endoplasmic Reticulum Stress to Correct Vascular Insulin Resistance and Glycemic Dysregulation
null
University of Missouri-Columbia
COMPLETED
INTERVENTIONAL
["NA"]
8
University of Missouri-Columbia
OTHER
[]
["Type 2 Diabetes Mellitus"]
["DIETARY_SUPPLEMENT: Tauroursodeoxycholic acid", "DIETARY_SUPPLEMENT: Placebo"]
The purpose of the present study is to determine if use of dietary supplement tauroursodeoxycholic acid enhances insulin-stimulated leg blood flow and glucose disposal.
ALL
20 Years
65 Years
false
2015-10-28
2018-02-14
2017-08-15
2017-11-06
2018-02-19
[{"facility": "University of Missouri", "city": "Columbia", "state": "Missouri", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT03331432
2026-05-14T17:51:04.875Z
NCT05785832
A Randomized Trial Evaluating Control-IQ+ Technology in Adults With Type 2 Diabetes
A Randomized Trial Evaluating the Efficacy and Safety of Control-IQ+ Technology in Adults With Type 2 Diabetes Using Basal-Bolus Insulin Therapy (2IQP)
2IQP
Tandem Diabetes Care, Inc.
COMPLETED
INTERVENTIONAL
["NA"]
319
Tandem Diabetes Care, Inc.
INDUSTRY
["Jaeb Center for Health Research"]
["Type 2 Diabetes Treated With Insulin"]
["DEVICE: t:slim X2 insulin pump with Control-IQ+ technology and Dexcom G6 CGM", "DEVICE: Standard Therapy plus continuous glucose monitoring (CGM)"]
A randomized controlled trial (RCT) to assess the safety and efficacy of use of Control-IQ+ technology in adults with type 2 diabetes using basal-bolus insulin therapy.
ALL
18 Years
null
false
2023-06-01
2024-09-24
2024-09-24
2023-03-27
2026-02-19
[{"facility": "Hoag Memorial Hospital Presbyterian", "city": "Newport Beach", "state": "California", "country": "United States"}, {"facility": "Emory University School of Medicine", "city": "Atlanta", "state": "Georgia", "country": "United States"}, {"facility": "Rocky Mountain Clinical Research", "city": "Idaho Falls"...
true
https://clinicaltrials.gov/study/NCT05785832
2026-05-14T17:51:04.914Z
NCT03314714
Duality of Lipids: the Athlete's Paradox
The Dual Role of Intramyocellular Lipids in Mediating Insulin Resistance: Assessing the Mechanisms of the Athlete's Paradox
LIDDIA
German Diabetes Center
COMPLETED
INTERVENTIONAL
["NA"]
100
German Diabetes Center
OTHER
["Maastricht University"]
["Insulin Resistance, Diabetes", "Lipid Metabolism Disorders"]
["PROCEDURE: Acute bout of endurance exercise"]
Accumulation of intramyocellular lipids (IMCLs) due to increased supply of fatty acids can induce defects in the insulin signaling cascade, causing skeletal muscle insulin resistance. However, the causes for muscle insulin resistance are not well understood. The association of elevated IMCLs and insulin resistance has ...
ALL
18 Years
69 Years
true
2017-04-03
2023-06-01
2023-06-01
2017-10-19
2023-06-13
[{"facility": "German Diabetes Center", "city": "Düsseldorf", "state": "North Rhine-Westphalia", "country": "Germany"}, {"facility": "Maastricht University", "city": "Maastricht", "state": null, "country": "Netherlands"}]
false
https://clinicaltrials.gov/study/NCT03314714
2026-05-14T17:51:04.940Z
NCT06760416
Online Diabetic Foot Support Program- Care Kit
Effect of Online Diabetic Foot Support Program (DiaFootSuP) and Care Kit on Diabetic Foot Care Outcomes: Randomized Controlled Trial
DiaFootSuP
Dokuz Eylul University
ACTIVE_NOT_RECRUITING
INTERVENTIONAL
["NA"]
62
Merve GÃnbaAY
OTHER
["The Scientific and Technological Research Council of Turkey"]
["Diabetes Mellitus", "Diabetic Foot Ulcer", "Diabetic Foot"]
["OTHER: Nursing Education"]
The aim of this project is to examine the effects of the online diabetic foot support program (DiaFootSuP) and care kit applied to type 2 diabetic individuals who have previously had a diabetic foot ulcer on diabetic foot outcomes (diabetic foot knowledge level, foot care behavior level, foot care self-efficacy level, ...
ALL
18 Years
null
false
2024-11-01
2025-03-31
2024-12-27
2025-01-06
2025-01-06
[{"facility": "Dokuz Eylül University", "city": "Izmir", "state": "Buca", "country": "Turkey (Türkiye)"}]
false
https://clinicaltrials.gov/study/NCT06760416
2026-05-14T17:51:04.983Z
NCT04024306
Steroid-induced Diabetes Mellitus in Systemic Lupus Erythematosus (SLE) Patients
Steroid-induced Diabetes Mellitus in Systemic Lupus Erythematosus (SLE) Patients
null
Assiut University
UNKNOWN
OBSERVATIONAL
[]
120
Assiut University
OTHER
[]
["System; Lupus Erythematosus"]
[]
The aim of the study is to determine the prevalence of steroid-induced diabetes mellitus (SDM) among systemic lupus erythematosus (SLE) patients and identify and assess the associated risk factors .
ALL
18 Years
75 Years
false
2022-09-01
2024-04-20
2024-04-01
2019-07-18
2023-07-19
[{"facility": "Assiut university hospital", "city": "Asyut", "state": null, "country": "Egypt"}]
false
https://clinicaltrials.gov/study/NCT04024306
2026-05-14T17:51:04.999Z
NCT00607906
First-Time-in-Humans Study to Assess Safety, Pharmacokinetics & Pharmacodynamics of SB756050
A Single-blinded, Randomized, Placebo-controlled, Staggered-parallel, Escalating Single Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Orally Administered SB756050 in Healthy Volunteers and in Subjects With Type 2 Diabetes Mellitus
null
GlaxoSmithKline
COMPLETED
INTERVENTIONAL
["PHASE1"]
36
GlaxoSmithKline
INDUSTRY
[]
["Diabetes Mellitus, Type 2"]
["DRUG: SB-756050 immediate release capsule", "DRUG: SB-756050 modified release capsule", "DRUG: Placebo"]
This study will use single escalating doses of SB756050 to assess safety, pharmacokinetics, and pharmacodynamics in healthy volunteers and in subjects with Type 2 Diabetes Mellitus.
ALL
18 Years
60 Years
true
2007-11-16
2008-03-10
2008-03-10
2008-02-06
2017-09-06
[{"facility": "GSK Investigational Site", "city": "Minneapolis", "state": "Minnesota", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT00607906
2026-05-14T17:51:05.053Z
NCT05251506
The Evaluation of Laser Lancing Devices in Adult Type 2 Diabetes Patients
The Evaluation of Laser Lancing Devices in Constructing Self-management Systems for Chronic Diseases in Adult Diabetes Patients
null
Korea University Guro Hospital
UNKNOWN
INTERVENTIONAL
["NA"]
80
Korea University Guro Hospital
OTHER
["Korea Medical Device Development Fund"]
["Type 2 Diabetes"]
["DEVICE: laser lancing device or lancet for blood glucose level measurement"]
Self monitoring of blood glucose level is crucial in diabetes management, but currently available methods, lancet, have shown low compliance of self monitoring of blood glucose because of pain, keratinization of finger tip, secondary infection. The purpose of this study is evaluating laser lancing device which cause mu...
ALL
20 Years
79 Years
false
2021-08-10
2022-12-31
2022-03-31
2022-02-22
2022-02-22
[{"facility": "Korea University medical center", "city": "Seoul", "state": null, "country": "South Korea"}]
false
https://clinicaltrials.gov/study/NCT05251506
2026-05-14T17:51:05.121Z
NCT02898506
Incretin-based Therapy in Late Preclinical Type 1 Diabetes
Incretin-based Therapy in Late Preclinical Type 1 Diabetes
null
University of Oulu
COMPLETED
INTERVENTIONAL
["PHASE2"]
13
University of Oulu
OTHER
["Oulu University Hospital", "Tampere University Hospital", "Turku University Hospital", "Skane University Hospital"]
["Type 1 Diabetes"]
["DRUG: Victoza®", "DRUG: Placebo"]
The objective of the trial is to study whether daily treatment with liraglutide improves endogenous insulin secretion, postpones progression to overt Type 1 diabetes, and is tolerable and safe in subjects aged 10-30 years, who are positive for multiple islet autoantibodies and have dysglycemia.
ALL
10 Years
30 Years
false
2016-03
2021-06
2021-06
2016-09-13
2022-01-25
[{"facility": "University of Oulu and Oulu University Hospital, Dept of Children and Adolescents", "city": "Oulu", "state": null, "country": "Finland"}, {"facility": "University of Tampere and Tampere University Hospital", "city": "Tampere", "state": null, "country": "Finland"}, {"facility": "University of Turku and Tu...
false
https://clinicaltrials.gov/study/NCT02898506
2026-05-14T17:51:05.147Z
NCT04361552
Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)
Tociluzumab for Cytokine Release Syndrome With SARS-CoV-2: An Open-Labeled, Randomized Phase 3 Trial
null
Emory University
WITHDRAWN
INTERVENTIONAL
["PHASE3"]
0
Emory University
OTHER
["National Cancer Institute (NCI)"]
["Cerebrovascular Accident", "Chronic Obstructive Pulmonary Disease", "Chronic Renal Failure", "Coronary Artery Disease", "Diabetes Mellitus", "Malignant Neoplasm", "SARS Coronavirus 2 Infection"]
["OTHER: Best Practice", "BIOLOGICAL: Tocilizumab"]
This phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection. CRS is a potentially serious disorder caused by the release of an excessive amount of substance that is made by cells of the...
ALL
18 Years
null
false
2020-04-07
2020-06-02
2020-06-02
2020-04-24
2020-06-18
[{"facility": "Emory University Hospital/Winship Cancer Institute", "city": "Atlanta", "state": "Georgia", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT04361552
2026-05-14T17:51:05.194Z
NCT05184049
Effects of Epalrestat on Peripheral Neuropathy and Central Nervous System in Diabetic Patients
Effects of Epalrestat on Peripheral Neuropathy and Central Nervous System in Diabetic Patient
null
Xiangya Hospital of Central South University
UNKNOWN
INTERVENTIONAL
["PHASE4"]
72
Xiangya Hospital of Central South University
OTHER
[]
["Diabetes"]
["DRUG: Epalrestat,Mecobalamin", "DRUG: Mecobalamin"]
This study evaluated the efficacy of epalrestat in diabetic peripheral neuropathy and its effects on the central nervous system in diabetic peripheral neuropathy subjects.
ALL
18 Years
65 Years
false
2022-01
2023-10
2023-10
2022-01-11
2022-01-11
[{"facility": "Xiangya Hospital of Central South University", "city": "Changsha", "state": "Hunan", "country": "China"}]
false
https://clinicaltrials.gov/study/NCT05184049
2026-05-14T17:51:05.210Z
NCT00806338
An Ascending Multi-Dose, Tolerance and Pharmacokinetic Study in Obese or Overweight Type 2 Diabetic Volunteers
A Phase I, Double-Blind, Randomized, Placebo-Controlled Ascending IV Multiple Dose Tolerance and Pharmacokinetic Study of Trodusquemine (MSI-1436) in Obese or Overweight Type 2 Diabetic Volunteers
null
Genaera Corporation
COMPLETED
INTERVENTIONAL
["PHASE1"]
22
Genaera Corporation
INDUSTRY
[]
["Diabetes Mellitus", "Obesity"]
["DRUG: Trodusquemine (MSI-1436)", "DRUG: Placebo"]
The purpose of this study is to evaluate the safety and tolerance of multiple intravenous (through a vein) doses of trodusquemine (MSI-1436) in obese or overweight, type 2 diabetics.
ALL
18 Years
65 Years
false
2008-11
2009-04
2009-04
2008-12-10
2009-04-15
[{"facility": "Cetero Research", "city": "Miami Gardens", "state": "Florida", "country": "United States"}, {"facility": "dgd Research", "city": "San Antonio", "state": "Texas", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT00806338
2026-05-14T17:51:05.234Z
NCT07258758
Diabetes Intervention Involving Person-centred Nutritional Education
Diabetes Intervention Involving Person-centred Nutritional Education (DINE) - Exploring the Benefits and Challenges of a Person-centred Education on the Nordic Diet for Adults With Type 1 Diabetes.
DINE
Umeå University
RECRUITING
INTERVENTIONAL
["NA"]
54
Umeå University
OTHER
["Lasarettet i Enköping"]
["Diabetes Type 1"]
["BEHAVIORAL: Dietary intervention"]
The overall objective for this project is to evaluate the effects of a person-centred education intervention to promote a healthy, sustainable Nordic diet compared with the current practice of providing short dietary information on health outcomes of adults with Type 1 diabetes. The study will measure the intervention'...
ALL
18 Years
null
false
2025-09-01
2027-06
2027-06
2025-12-02
2025-12-12
[{"facility": "Hospital of Enköping", "city": "Enköping", "state": "Uppland", "country": "Sweden"}]
false
https://clinicaltrials.gov/study/NCT07258758
2026-05-14T17:51:05.277Z
NCT03574558
Personalized Automated Determination of Insulin Pump Setting for Subjects With Type 1 Diabetes Switching From MDI to Pump Therapy and Vice Versa- Safety and Efficacy Feasibility Study
Personalized Automated Determination of Insulin Pump Setting for Subjects With Type 1 Diabetes Switching From MDI to Pump Therapy and Vice Versa- Safety and Efficacy Feasibility Study
null
Rabin Medical Center
COMPLETED
INTERVENTIONAL
["NA"]
28
Rabin Medical Center
OTHER
["Juvenile Diabetes Research Foundation", "Jaeb Center for Health Research", "DreaMed", "University of Padova"]
["Type1diabetes"]
["DEVICE: MD-Logic Switch Advisor"]
The "MD-Logic Switch Advisor" is a software product that is designed to assist in insulin dosage decision making and has two components: A. MD-Logic Switch Advisor for initiation of pump therapy - this product is designed to assist physicians in decision making when initiating insulin pump therapy. B. MD-Logic Switch...
ALL
6 Years
30 Years
false
2018-08-01
2019-11-25
2019-11-25
2018-07-02
2019-12-27
[{"facility": "Schnider children's medical center", "city": "Petah Tikva", "state": null, "country": "Israel"}]
false
https://clinicaltrials.gov/study/NCT03574558
2026-05-14T17:51:05.316Z
NCT00516958
Pilot Study of the Safety and Clinical Efficacy of Topical Dermacyn™ Wound Care to Treat Mild Diabetic Foot Infections
An Open Label, Three Arm, Pilot Study of the Safety and Clinical Efficacy of Topical Dermacyn™ Wound Care vs. Oral Levofloxacin vs. Combined Therapy for Mild Diabetic Foot Infections
null
Oculus Innovative Sciences, Inc.
COMPLETED
INTERVENTIONAL
["PHASE2"]
65
Oculus Innovative Sciences, Inc.
INDUSTRY
[]
["Foot Ulcer, Diabetic"]
["DRUG: Topical Dermacyn", "DRUG: Topical Dermacyn and Levofloxacin", "DRUG: Topical Saline and Levofloxacin"]
To compare the rates of clinical success of Topical Dermacyn™ vs. Oral Levofloxacin vs. Combined therapy, in subjects with mild diabetic foot infections in non-ischemic ulcers.
ALL
18 Years
null
false
2007-05
2007-12
2007-12
2007-08-16
2008-01-14
[{"facility": null, "city": "Tucson", "state": "Arizona", "country": "United States"}, {"facility": null, "city": "La Jolla", "state": "California", "country": "United States"}, {"facility": null, "city": "Los Angeles", "state": "California", "country": "United States"}, {"facility": null, "city": "San Diego", "state":...
false
https://clinicaltrials.gov/study/NCT00516958
2026-05-14T17:51:05.347Z
NCT03510078
Intensive Versus Conventional Hyperglycemic Control in Hospitalized Non-critically Ill Patients
Intensive Versus Conventional Hyperglycemic Control in Hospitalized Non-critically Ill Patients
null
Rabin Medical Center
COMPLETED
INTERVENTIONAL
["NA"]
600
Rabin Medical Center
OTHER
[]
["Diabetes Mellitus", "Non-critically Ill Patients"]
["DRUG: Insulin"]
Hyperglycemia is a common condition among hospitalized patients. The occurrence of severe hyperglycemia is associated with increased morbidity and mortality in several populations. Several trials assessed the benefits of aggressive versus conventional glucose control. These studies evaluated different patient populatio...
ALL
18 Years
120 Years
false
2018-04-17
2025-12-10
2025-07-01
2018-04-27
2026-04-30
[{"facility": "Rabin Medical Center", "city": "Petah Tikva", "state": "Israel", "country": "Israel"}, {"facility": "Soroka University Medical Center", "city": "Beersheba", "state": null, "country": "Israel"}, {"facility": "Rambam Medical Center", "city": "Haifa", "state": null, "country": "Israel"}, {"facility": "Shami...
false
https://clinicaltrials.gov/study/NCT03510078
2026-05-14T17:51:05.400Z
NCT01293578
Study to Test Use of a Decision Aid in a Clinical Visit to Help Patients Choose a Diabetes Medication
Translating Information on Comparative Effectiveness Into Practice (TRICEP)
TRICEP
Mayo Clinic
COMPLETED
INTERVENTIONAL
["NA"]
550
Mayo Clinic
OTHER
[]
["Type 2 Diabetes Mellitus"]
["OTHER: Diabetes Medication Choice Cards"]
The goal of this study is to test the relative merits of a decision aid for diabetes medications that we have developed - Diabetes Medication Choice Cards- versus usual care in translating comparative effectiveness research (CER) into real world clinics. This study will involve about 20 primary care practice sites affi...
ALL
18 Years
null
true
2011-01
2015-06
2015-06
2011-02-10
2022-09-28
[{"facility": "Albert Lea Medical Center", "city": "Albert Lea", "state": "Minnesota", "country": "United States"}, {"facility": "Mayo Clinic Kasson", "city": "Kasson", "state": "Minnesota", "country": "United States"}, {"facility": "Mayo Clinic Health System- Immanual St. Joseph's", "city": "Mankato", "state": "Minnes...
false
https://clinicaltrials.gov/study/NCT01293578
2026-05-14T17:51:05.417Z
NCT05659043
Glycation of apoA-I and Diabetic Atherogenesis
The Impact of Glycation Modification of apoA-I on HDL Function and Atherogenesis in Type Diabetes Mellitus
null
Ruijin Hospital
UNKNOWN
OBSERVATIONAL
[]
2,000
Ruijin Hospital
OTHER
[]
["Diabetes Mellitus, Type 2"]
["OTHER: overnight fasting"]
The goal of this study is to determine the relationship of apoprotein A-1 (apoA-I) glycation and development of diabetic atherosclerosis. ApoA-I is crucial for reverse cholesterol transport and anti-inflammation/anti-atherosclersis functions of HDL. However, apoA-I is easily subjected to non-enzymatic glycation modifi...
ALL
18 Years
90 Years
false
2017-01
2023-12
2021-12
2022-12-21
2022-12-21
[{"facility": "Ruijin Hospital, Shanghai Jiaotong University School of Medicine", "city": "Shanghai", "state": "Shanghai Municipality", "country": "China"}]
false
https://clinicaltrials.gov/study/NCT05659043
2026-05-14T17:51:05.501Z
NCT05767255
Risk of Hypoglycemia in the Transition From Inpatient to Outpatient Setting. Comparative Study of Basal-bolus Insulin Versus Basal Insulin Plus GLP-1 Analogue
Risk of Hypoglycemia in the Transition From Inpatient to Outpatient Setting. Comparative Study of Basal-bolus Insulin Versus Basal Insulin Plus GLP-1 Analogue
null
Hospital Universitario San Ignacio
UNKNOWN
INTERVENTIONAL
["PHASE3"]
66
Hospital Universitario San Ignacio
OTHER
[]
["Diabetes Mellitus, Type 2 Treated With Insulin"]
["DRUG: insulin degludec + liraglutide", "DRUG: Insulin Glargine - Insulin Aspart"]
The association of insulin degludec with liraglutide in the same device (IDegLira) is a potent but at the same time safe drug that reduces the risk of hypoglycemia when compared to a basal or basal-bolus insulin schedule. The DUAL (Dual Action of Liraglutide and Insulin Degludec) studies are the pivotal studies of thi...
ALL
18 Years
null
false
2022-12-01
2023-08-30
2023-08-30
2023-03-14
2023-03-14
[{"facility": "Hospital Universitario San Ignacio", "city": "Bogotá", "state": null, "country": "Colombia"}]
false
https://clinicaltrials.gov/study/NCT05767255
2026-05-14T17:51:05.540Z
NCT05959135
Gastric Ultrasound in Diabetic and Non-Diabetic Pregnant Women
Ultrasound Evaluation of Gastric Content in Diabetic and Non-Diabetic Term Pregnant Women: An Observational Study
null
Sisli Hamidiye Etfal Training and Research Hospital
COMPLETED
OBSERVATIONAL
[]
80
Sisli Hamidiye Etfal Training and Research Hospital
OTHER
[]
["Gastric Ultrasonography", "Gastric Volume", "Pulmonary Aspiration", "Diabetic Pregnancy", "Fasting"]
["DEVICE: Gastric ultrasonography"]
Perioperative aspiration is particularly concerning in pregnant women due to anatomical changes. To mitigate this risk, pre-anesthetic fasting is recommended, with varying guidelines. Gastric ultrasound can non-invasively assess stomach contents, and mathematical models help estimate stomach volumes using the gastric a...
FEMALE
18 Years
40 Years
true
2023-07-26
2023-12-25
2023-12-10
2023-07-25
2023-12-29
[{"facility": "Sisli Hamidiye Etfal Training and Research Hospital", "city": "Sarıyer", "state": "Istanbul", "country": "Turkey (Türkiye)"}]
false
https://clinicaltrials.gov/study/NCT05959135
2026-05-14T17:51:05.560Z
NCT06912035
Efficacy of Diacerein Supplementation on Interleukin-1β, Hs-CRP, TNF-α Levels and Glycemic Control in Uncontrolled Type 2 Diabetes Mellitus Patients at Dr. Mohammad Hoesin General Hospital Palembang
EFFICACY OF DIACEREIN ADDITION ON INTERLEUKIN-1Β, HS-CRP, TNF-Α LEVELS AND GLYCEMIC CONTROL IN UNCONTROLLED TYPE 2 DIABETES MELLITUS PATIENTS AT DR. MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG
null
Universitas Sriwijaya
COMPLETED
INTERVENTIONAL
["PHASE2", "PHASE3"]
34
Universitas Sriwijaya
OTHER
["Indonesia Endowment Fund for Education (LPDP), Ministry of Finance Republik of Indonesia"]
["Uncontrolled Diabetes", "Diabetes Mellitus Type 2"]
["DRUG: Diacerein 50 mg Capsule", "DRUG: Placebo"]
The goal of this clinical trial is to learn if diacerein supplementation can help improve inflammation and glycemic control in adults with uncontrolled type 2 diabetes. It will also study the safety and tolerability of diacerein. The main questions it aims to answer are: * Does diacerein lower levels of inflammatory m...
ALL
60 Years
60 Years
false
2024-06-21
2024-11-08
2024-11-08
2025-04-04
2025-04-04
[{"facility": "Universitas Sriwijaya", "city": "Palembang", "state": "South Sumatera", "country": "Indonesia"}]
false
https://clinicaltrials.gov/study/NCT06912035
2026-05-14T17:51:05.603Z
NCT01973374
Sugar Text: A Randomized Controlled Trial of a Text Message Intervention for Women With Diabetes in Pregnancy
Sugar Text: A Randomized Controlled Trial of a Text Message Intervention for Women With Diabetes in Pregnancy
Sugar Text
University of Pennsylvania
COMPLETED
INTERVENTIONAL
["NA"]
30
University of Pennsylvania
OTHER
[]
["Diabetes in Pregnancy", "Gestational Diabetes", "Texting Interventions"]
["BEHAVIORAL: Text Message Intervention"]
Maternal diabetes in pregnancy can negatively impact fetal well-being and contribute to adverse pregnancy outcomes. Much of the morbidity associated with diabetes in pregnancy can be minimized with tight glucose control. A number of studies in non-pregnant populations have highlighted the feasibility, acceptability and...
FEMALE
18 Years
50 Years
false
2013-01
2014-04
2014-04
2013-10-31
2015-02-20
[{"facility": "Hospital of the University of Pennsylvania", "city": "Philadelphia", "state": "Pennsylvania", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT01973374
2026-05-14T17:51:05.645Z
NCT02607410
Sitagliptin (DPP-4 Inhibitor) and NPH Insulin in Patients With T2D
Short and Long Term Effects of a Dypeptidil-peptidase-4 Versus Bedtime NPH Insulin as add-on Therapy in Patients With Type 2 Diabetes
null
University of Sao Paulo General Hospital
COMPLETED
INTERVENTIONAL
["PHASE4"]
40
University of Sao Paulo General Hospital
OTHER
["Fundação de Amparo à Pesquisa do Estado de São Paulo"]
["Type 2 Diabetes Mellitus"]
["DRUG: sitagliptin", "DRUG: NPH insulin"]
To compare the short and long term effects of inhibitor of the DPP-IV enzyme, sitagliptin , with bedtime NPH insulin in patients with T2D inadequately controlled with sulphonylurea plus biguanide: effects on beta cell function and on metabolic profile.
ALL
35 Years
70 Years
false
2010-01
2014-07
2012-01
2015-11-18
2015-11-18
[{"facility": "University of Sao Paulo General Hospital", "city": "São Paulo", "state": "São Paulo", "country": "Brazil"}]
false
https://clinicaltrials.gov/study/NCT02607410
2026-05-14T17:51:05.688Z
NCT07147010
Evaluation of Correlations Between Volatile Organic Compounds and Venous Blood Glucose in Subjects With Type 2 Diabetes
Evaluation of Correlations Between Volatile Organic Compounds (VOCs) Spectra Measured With GC-IMS and MOx-sensors and Venous Blood Glucose in Subjects With Type 2 Diabetes
Evo
DCB Research AG
COMPLETED
INTERVENTIONAL
["NA"]
20
DCB Research AG
OTHER
["Insel Gruppe AG, University Hospital Bern", "BOYDSENSE"]
["Type 2 Diabetes"]
["DEVICE: MIB Breath Analyzer"]
The goal of this study is to evaluate correlations between VOCs in the breath and venous blood glucose values in various glycaemic states in people living with Type 2 Diabetes. VOCs are measured with a gold-standard GC-IMS device and a prototype of a novel breath analyzer. Participants will be exposed to different blo...
ALL
45 Years
70 Years
false
2024-10-01
2025-11-27
2025-03-30
2025-08-28
2025-12-09
[{"facility": "Inselspital Bern", "city": "Bern", "state": null, "country": "Switzerland"}]
false
https://clinicaltrials.gov/study/NCT07147010
2026-05-14T17:51:05.735Z
NCT05191160
The Soy Treatment Evaluation for Metabolic Health (STEM) Trial
Role of Soy for Metabolic Health: The Soy Treatment Evaluation for Metabolic Health (STEM) Trial
null
University of Toronto
UNKNOWN
INTERVENTIONAL
["NA"]
186
University of Toronto
OTHER
["United Soybean Board"]
["Metabolic Syndrome", "Overweight and Obesity", "PreDiabetes", "Diabetes", "Healthy Obesity, Metabolically", "Overweight", "Obesity", "Dysglycemia", "Cardiovascular Diseases", "Heart Disease Risk Factors", "Hypertension", "Dyslipidemias"]
["OTHER: Soy Milk", "OTHER: Cow's Milk", "OTHER: Sugar Sweetened Beverages"]
Strategies to reduce sugar-sweetened beverages (SSB) have become one of the leading public health targets to address the epidemics of obesity and diabetes. National food, nutrition, and health policies and programs have positioned low-fat milk as the preferred caloric replacement strategy for SSBs. This strategy derive...
ALL
18 Years
75 Years
true
2021-11-02
2025-03-30
2024-10-30
2022-01-13
2024-04-18
[{"facility": "Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital", "city": "Toronto", "state": "Ontario", "country": "Canada"}]
false
https://clinicaltrials.gov/study/NCT05191160
2026-05-14T17:51:05.781Z
NCT06145360
Evaluating the Efficacy and Safety of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes and Obese Patient
Effectivity of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes
null
SINA Health Education and Welfare Trust
COMPLETED
INTERVENTIONAL
["PHASE4"]
150
SINA Health Education and Welfare Trust
OTHER
["Horizon Pharmaceutical Pvt Ltd"]
["Glucose Metabolism Disorders", "Diabetes Mellitus, Type 2", "Hypoglycemic Agents", "Empagliflozin"]
["DRUG: Empagliflozin 10 MG", "DRUG: Insulin+Metformin+DPP4 inhibitor (DPP4I)"]
The primary aim of this study is to assess the impact of incorporating Empagliflozin, an oral sodium-glucose co-transporter 2 (SGLT2) inhibitor, into the existing therapeutic regimen of Insulin+Metformin+Dipeptidyl peptidase 4 (DPP-4) inhibitors in poorly controlled type 2 diabetes mellitus (T2DM) patients. The study s...
ALL
20 Years
70 Years
false
2023-12-01
2024-03-01
2024-03-01
2023-11-24
2024-04-08
[{"facility": "SINA Shireen Jinnah colony", "city": "Karachi", "state": null, "country": "Pakistan"}]
false
https://clinicaltrials.gov/study/NCT06145360
2026-05-14T17:51:05.821Z
NCT02806960
A Study of Single and Repeated Doses of Glucagon Administered to Participants With Diabetes
A Single Center, Randomized, 4-Period Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of Single or Repeated 3 mg Doses of Intranasally Administered Glucagon in Adults With Type 1 or Type 2 Diabetes
null
Eli Lilly and Company
TERMINATED
INTERVENTIONAL
["PHASE1"]
12
Eli Lilly and Company
INDUSTRY
["Locemia Solutions ULC"]
["Diabetes Mellitus, Type 1", "Diabetes Mellitus, Type 2"]
["DRUG: Nasal Glucagon"]
This study will investigate how the body processes nasal glucagon and the effect of nasal glucagon on the body. After an 8-hour overnight fast and 4 hours after the start of a low-carbohydrate breakfast, the study drug will be delivered into the participant's nostril(s) (intranasally) once or twice in each of four stud...
ALL
18 Years
70 Years
false
2014-06
2014-08
2014-06
2016-06-21
2019-12-13
[{"facility": "For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.", "city": "Mount Royal", "state": "Quebec", "country": "Canada"}]
true
https://clinicaltrials.gov/study/NCT02806960
2026-05-14T17:51:05.866Z
NCT06273124
Investigational Extended Wear Insulin Infusion Set in People With Type 1 Diabetes
Open, Single Arm, Prospective, Multicenter Study of an Investigational Extended Wear Insulin Infusion Set During Home Use in People With Type 1 Diabetes
null
Tandem Diabetes Care, Inc.
COMPLETED
INTERVENTIONAL
["NA"]
260
Tandem Diabetes Care, Inc.
INDUSTRY
["Jaeb Center for Health Research"]
["Type1diabetes"]
["DEVICE: SteadiSet Extended Wear Infusion Set"]
The purpose of this study is to collect clinical data to support a 7-day wear of the Extended Wear Infusion Set (EWIS). Participants will be asked to: 1. Wear the EWIS for up to 7 consecutive days for 12 consecutive wear periods 2. Perform blood glucose and ketone measurements if continuous glucose meter is ≥250mg/dL...
ALL
18 Years
80 Years
false
2024-03-07
2024-12-11
2024-12-11
2024-02-22
2025-09-24
[{"facility": "Hoag Memorial Hospital Presbyterian", "city": "Newport Beach", "state": "California", "country": "United States"}, {"facility": "Stanford University", "city": "Stanford", "state": "California", "country": "United States"}, {"facility": "Barbara Davis Center", "city": "Aurora", "state": "Colorado", "count...
true
https://clinicaltrials.gov/study/NCT06273124
2026-05-14T17:51:05.902Z
NCT07139964
High-Dose Vitamin D3 for Diabetic Foot Ulcer Healing: Randomized Controlled Trial
Effectiveness of High-Dose Vitamin D3 in Improving Diabetic Foot Ulcer Healing by Reducing the MMP-9 to TIMP-1 Ratio: Randomized Double-Blind Placebo-Controlled Trial
DFU
Universitas Sriwijaya
COMPLETED
INTERVENTIONAL
["NA"]
24
Universitas Sriwijaya
OTHER
[]
["Diabetic Foot Ulcer", "Vitamin D Deficiency", "Wound Healing Disorder"]
["DIETARY_SUPPLEMENT: Vitamin D3", "OTHER: Placebo"]
This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effectiveness of high-dose vitamin D3 supplementation in improving diabetic foot ulcer (DFU) healing. DFUs are common, serious complications of diabetes, often associated with delayed wound healing due to persistent inflammation, impa...
ALL
18 Years
null
false
2024-07-01
2025-07-31
2025-01-31
2025-08-24
2025-08-24
[{"facility": "Dr. Mohammad Hoesin General Hospital", "city": "Palembang", "state": "South Sumatra", "country": "Indonesia"}]
false
https://clinicaltrials.gov/study/NCT07139964
2026-05-14T17:51:05.981Z
NCT02776098
Muscle Accrual and Function in Cystic Fibrosis-Impact of Glucose Intolerance
Muscle Accrual and Function in Cystic Fibrosis-Impact of Glucose Intolerance
null
Children's Hospital of Philadelphia
COMPLETED
OBSERVATIONAL
[]
54
Children's Hospital of Philadelphia
OTHER
["National Institutes of Health (NIH)", "University of Pennsylvania", "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)"]
["Cystic Fibrosis"]
[]
This study will investigate the link between glucose abnormalities and elements critical to muscle function including mass, composition and energy metabolism. the primary goal of the study is to determine whether Cystic Fibrosis (CF) disease is associated with muscle dysfunction, especially in the presence of glucose i...
ALL
12 Years
null
true
2016-05
2024-03-04
2024-03-04
2016-05-18
2024-03-07
[{"facility": "Children's Hospital of Philadelphia", "city": "Philadelphia", "state": "Pennsylvania", "country": "United States"}, {"facility": "University of Pennsylvania", "city": "Philadelphia", "state": "Pennsylvania", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT02776098
2026-05-14T17:51:06.023Z
NCT02423798
New Generation Enlite Accuracy Study
Accuracy and Performance Evaluation of the Medtronic New Generation Enlite Glucose Sensor in Conjunction With the Medtronic 640G System Components - in Clinic and at Home
null
Medtronic MiniMed, Inc.
COMPLETED
INTERVENTIONAL
["NA"]
24
Medtronic MiniMed, Inc.
INDUSTRY
["Profil Institut für Stoffwechselforschung GmbH"]
["Diabetes"]
["DEVICE: Glucose sensor (Enlite)"]
The trial will investigate the accuracy and performance of a new sensor for continuous glucose monitoring (CGM), the (new generation) Enlite, CE-marked in 2013, in conjunction with the new Medtronic 640G system components. To evaluate the accuracy and performance of the new generation Enlite sensor. This is a postmark...
ALL
18 Years
74 Years
false
2015-04
2015-09
2015-09
2015-04-22
2018-01-17
[]
true
https://clinicaltrials.gov/study/NCT02423798
2026-05-14T17:51:06.079Z
NCT02589314
Effect of Periodontal Therapy in the Systemic Status of Individuals With Chronic Periodontitis and Diabetes Type 2
Effect of Mechanical Periodontal Therapy in the Microbiological, Immunocellular and Immunoglobulin Profiles and in the Dosage of Pro and Anti-inflammatory Cytokines From Peripheral Blood and Saliva of Subjects With Chronic Periodontitis and Diabetes Type 2
null
University of Brasilia
TERMINATED
OBSERVATIONAL
[]
90
University of Brasilia
OTHER
["Catholic University of Brasília", "Brasilia University Hospital"]
["Chronic Periodontitis", "Diabetes Type 2"]
["DEVICE: Mechanical periodontal therapy", "PROCEDURE: nonsurgical periodontal therapy"]
This study will evaluate if periodontal mechanical treatment is capable to alter immunological and genetical parameters related to systemic health in patients with chronic periodontitis ant diabetes type 2.
ALL
30 Years
65 Years
true
2015-11
2020-08
2019-09
2015-10-28
2020-08-24
[{"facility": "Priscilla Farias Naiff", "city": "Brasília", "state": "Federal District", "country": "Brazil"}]
false
https://clinicaltrials.gov/study/NCT02589314
2026-05-14T17:51:06.094Z
NCT00993304
A Trial to Assess the Effect of Liraglutide on Blood Triglyceride (Fat) Levels After a Meal in Type 2 Diabetics
A Trial to Assess the Effect of Liraglutide on Postprandial Triglyceride Levels in Subjects With Type 2 Diabetes
null
Novo Nordisk A/S
COMPLETED
INTERVENTIONAL
["PHASE1"]
20
Novo Nordisk A/S
INDUSTRY
[]
["Diabetes", "Diabetes Mellitus, Type 2"]
["DRUG: liraglutide", "DRUG: placebo"]
This trial is conducted in Europe. The aim of this trial is to investigate whether a new compound, liraglutide, reduces the level of lipids (fat), including cholesterol, in the blood of type 2 diabetics, following a meal with high fat content.
ALL
18 Years
null
false
2009-10
2010-12
2010-12
2009-10-12
2017-01-26
[{"facility": "Novo Nordisk Investigational Site", "city": "Aarhus C", "state": null, "country": "Denmark"}]
false
https://clinicaltrials.gov/study/NCT00993304
2026-05-14T17:51:06.125Z
NCT00312104
Comparison of Efficacy and Safety of Insulin Detemir and Insulin Glargine in Patients With Type 1 Diabetes
Comparison of Efficacy and Safety of Insulin Detemir and Insulin Glargine in Patients With Type 1 Diabetes.
null
Novo Nordisk A/S
COMPLETED
INTERVENTIONAL
["PHASE3"]
325
Novo Nordisk A/S
INDUSTRY
[]
["Diabetes", "Diabetes Mellitus, Type 1"]
["DRUG: insulin detemir", "DRUG: insulin glargine", "DRUG: insulin aspart"]
The trial is conducted in Europe and Africa. The aim of the trial is to compare the use of insulin detemir twice daily combined with mealtime insulin aspart against that of insulin glargine once daily combined with mealtime insulin aspart. The trial involves patients with Type 1 Diabetes.
ALL
18 Years
null
false
2002-04
2003-03
2003-03
2006-04-07
2017-01-27
[{"facility": "Novo Nordisk Investigational Site", "city": "Graz", "state": null, "country": "Austria"}, {"facility": "Novo Nordisk Investigational Site", "city": "Vienna", "state": null, "country": "Austria"}, {"facility": "Novo Nordisk Investigational Site", "city": "Vienna", "state": null, "country": "Austria"}, {"f...
false
https://clinicaltrials.gov/study/NCT00312104
2026-05-14T17:51:06.174Z
NCT01075347
Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Clinical Study: Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
null
National Taiwan University Hospital
COMPLETED
INTERVENTIONAL
["PHASE1"]
165
National Taiwan University Hospital
OTHER
[]
["Corneal Epithelial Defect", "Diabetic Retinopathy", "Penetrating Keratoplasty"]
["OTHER: autologous serum", "OTHER: Non-autologous serum"]
Ophthalmology ,cornea Autologous serum has long been known to be effective to promote corneal epithelial wound healing in a variety of ocular surface disorders. However, its effectiveness for corneal epithelial defects due to pars plana vitrectomy (PPV) for diabetic retinopathy and penetrating keratoplasty has seldom b...
ALL
20 Years
70 Years
true
2007-03
2008-03
2008-03
2010-02-25
2010-09-14
[{"facility": "National Taiwan University Hospital, department of Ophthalmology", "city": "Taipei", "state": "Taiwan", "country": "Taiwan"}]
true
https://clinicaltrials.gov/study/NCT01075347
2026-05-14T17:51:06.191Z
NCT05874726
Biological Sample Repository for Gastrointestinal Disorders
Biological Sample Repository for Gastrointestinal Disorders
null
Brigham and Women's Hospital
ACTIVE_NOT_RECRUITING
OBSERVATIONAL
[]
500
Pichamol Jirapinyo, MD, MPH
OTHER
["Tufts University", "Boston Children's Hospital", "Mayo Clinic"]
["Obesity", "Obesity, Morbid", "Obesity, Primary", "Gastro-Intestinal Disorder", "Overweight and Obesity", "Overweight", "Overweight or Obesity", "Diabetes Type 2", "Diabetes Mellitus", "Diabetes Mellitus, Type 2", "Hypertension", "Hyperlipidemias", "Sleep Apnea", "GERD", "Gastroesophageal Reflux", "Musculoskeletal Pai...
["DIAGNOSTIC_TEST: Blood Collection", "DIAGNOSTIC_TEST: Urine Collection", "DIAGNOSTIC_TEST: Tissue Sample Collection"]
The goal of this observational study has the purpose of collecting biological samples from obese patients undergoing evaluation for weight loss by means of medical or endoscopic therapies; and of post bariatric surgery patients presenting with short- and long-term surgical complications. The aim is to enhance the overa...
ALL
18 Years
null
false
2023-07-19
2029-04
2028-07
2023-05-25
2025-12-02
[{"facility": "Brigham and Women's Hospital", "city": "Boston", "state": "Massachusetts", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT05874726
2026-05-14T17:51:06.235Z
NCT00741026
A Crossover Study of the Acute Effects of Olanzapine in Healthy Volunteers
A Double-blind, Placebo-controlled, Crossover Study Examining the Acute Effects of Olanzapine on Plasma Leptin, Glucose Tolerance and Free Fatty Acids in Healthy Volunteers
null
Milton S. Hershey Medical Center
COMPLETED
INTERVENTIONAL
["NA"]
15
Milton S. Hershey Medical Center
OTHER
["American Medical Association"]
["Insulin Resistance", "Diabetes Mellitus"]
["DRUG: Olanzapine 10 mg po qhs for 3 days", "DRUG: Placebo"]
The purpose of this clinical research study is to examine the acute hormonal and metabolic effects of the drug olanzapine, as well as appetite effects, in healthy volunteers. The hypotheses to be tested are that: (1) Olanzapine rapidly attenuates plasma leptin and (2) rapidly alters glucose tolerance in healthy volunte...
ALL
18 Years
30 Years
true
2008-08
2011-05
2010-12
2008-08-25
2014-07-14
[{"facility": "Penn State College of Medicine, Penn State Milton S. Hershey Medical Center", "city": "Hershey", "state": "Pennsylvania", "country": "United States"}]
true
https://clinicaltrials.gov/study/NCT00741026
2026-05-14T17:51:06.252Z
NCT04532385
Effect of Green Tea Extract on Lipids in Patients With Type 2 Diabetes
Effect of a 12-week Administration of Green Tea Extract on Lipids in Patients With Type 2 Diabetes
HDL
Centro Universitario de Ciencias de la Salud, Mexico
COMPLETED
INTERVENTIONAL
["NA"]
20
Centro Universitario de Ciencias de la Salud, Mexico
OTHER
[]
["Diabetes Mellitus, Type 2", "Dyslipidemias", "Arterial Stiffness"]
["DIETARY_SUPPLEMENT: Green tea extract", "DIETARY_SUPPLEMENT: Placebo"]
The main objectives of this study were to evaluate the effect of a 12-week supplementation with GTE (400 mg every 12 hours) on serum lipids, arterial stiffness and inflammatory cytokines in patients with T2DM.
ALL
40 Years
65 Years
false
2018-06-12
2019-01-14
2019-01-14
2020-08-31
2020-08-31
[{"facility": "Institute of Experimental and Clinical Therapeutics (INTEC), CUCS, University of Guadalajara", "city": "Guadalajara", "state": "Jalisco", "country": "Mexico"}]
false
https://clinicaltrials.gov/study/NCT04532385
2026-05-14T17:51:06.273Z
NCT00108615
Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance
Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance
null
VA Office of Research and Development
COMPLETED
INTERVENTIONAL
["PHASE4"]
48
US Department of Veterans Affairs
FED
[]
["Glucose Metabolism Disorders", "Diabetes"]
["DRUG: Metformin", "DRUG: Pioglitazone", "DRUG: Metformin", "DRUG: Pioglitazone", "RADIATION: CT scans", "PROCEDURE: Oral glucose tolerance test"]
Subjects with impaired glucose tolerance will be randomized to receive pioglitazone or metformin for 10 weeks. Measurements of insulin sensitivity, body composition, glucose tolerance, and muscle lipid accumulation will be performed. Adipose tissue and muscle biopsies are performed. The goal of the study is to determin...
ALL
35 Years
65 Years
true
2004-01
2007-12
2007-04
2005-04-18
2008-04-25
[{"facility": "Central Arkansas Veterans HCS", "city": "Little Rock", "state": "Arkansas", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT00108615
2026-05-14T17:51:06.318Z
NCT05232708
A Clinical Trial Looking at the Comparability of 2 Different Forms of Semaglutide
A Study to Demonstrate Bioequivalence Between Semaglutide Formulation for the DV3396 Pen-injector and the Formulation for the PDS290 Semaglutide Pen-injector
null
Novo Nordisk A/S
COMPLETED
INTERVENTIONAL
["PHASE1"]
18
Novo Nordisk A/S
INDUSTRY
[]
["Healthy Volunteers (Diabetes Mellitus, Type 2)"]
["DRUG: Semaglutide B, 1.34 mg/mL", "DRUG: Semaglutide D, 1.0 mg/mL", "DRUG: Semaglutide D, 1.0 mg/mL", "DRUG: Semaglutide B, 1.34 mg/mL"]
In this trial, two approved solutions of the medicine semaglutide will be compared in healthy volunteers. The purpose of this trial is to see if semaglutide B and semaglutide D solutions are comparable with regards to moving into, through and out of the body when given in two separate injections. Participants will rece...
ALL
20 Years
55 Years
true
2022-01-19
2022-08-30
2022-08-30
2022-02-10
2024-01-26
[{"facility": "Parexel CPRU, Level 7", "city": "Harrow", "state": "Middlesex", "country": "United Kingdom"}]
false
https://clinicaltrials.gov/study/NCT05232708
2026-05-14T17:51:06.348Z
NCT00641407
Bedtime Insulins and Oral Antihyperglycemic Drugs in Type 2 Diabetes
Bedtime Insulin Glargine or Bedtime Neutral Protamine Lispro Combined With Sulfonylurea and Metformin in Type 2 Diabetes. A Randomized, Controlled Trial
null
University of Campania Luigi Vanvitelli
COMPLETED
INTERVENTIONAL
["PHASE4"]
100
University of Campania Luigi Vanvitelli
OTHER
[]
["Type 2 Diabetes Mellitus", "Hypoglycemia"]
["DRUG: NPL insulin", "DRUG: Insulin glargine"]
The maintenance of nearly normal glycemic levels reduces the risk of diabetic complications, but is difficult to achieve, despite the administration of escalating doses of oral antidiabetic drugs, such as metformin, sulfonylureas, and thiazolidinediones. Most patients eventually require insulin which usually is added w...
ALL
30 Years
70 Years
false
2007-01
2008-03
2007-12
2008-03-24
2008-03-31
[{"facility": "Department of Geriatrics and Metabolic Disease", "city": "Naples", "state": null, "country": "Italy"}]
false
https://clinicaltrials.gov/study/NCT00641407
2026-05-14T17:51:06.386Z
NCT04082000
Phase 2a Study Examining the Safety and Efficacy of BOL-DP-o-04 for Treating Diabetic Neuropathy
A Phase 2a Study Examining the Safety and Efficacy of BOL-DP-o-04 Sublingual Drops for Treating Diabetic Neuropathy
null
Breath of Life International Pharma Ltd
TERMINATED
INTERVENTIONAL
["PHASE1", "PHASE2"]
2
Breath of Life International Pharma Ltd
INDUSTRY
[]
["Diabetic Neuropathy"]
["DRUG: BOL-DP-o-04", "DRUG: Placebo"]
This is a randomized, double-blind, placebo-controlled Phase 2a Study Examining the Safety and Efficacy of BOL-DP-o-04 for Treating Diabetic Neuropathy
ALL
18 Years
80 Years
false
2019-04-15
2020-11-04
2020-11-04
2019-09-09
2021-03-24
[{"facility": "Wolfson Medical Center", "city": "Holon", "state": null, "country": "Israel"}]
false
https://clinicaltrials.gov/study/NCT04082000
2026-05-14T17:51:06.429Z
NCT07515807
Qatar Cardiometabolic Retrospective Cohort-Analysis Using Artificial Intelligence
Qatar Cardiometabolic Retrospective Cohort-Analysis Using Artificial Intelligence
QCRC-AI
Weill Cornell Medical College in Qatar
NOT_YET_RECRUITING
OBSERVATIONAL
[]
10,000
Weill Cornell Medical College in Qatar
OTHER
["Hamad Medical Corporation"]
["Cardio Vascular Disease", "Acute Coronary Syndromes (ACS)", "Type 2 Diabetes", "Pre Diabetes", "Artifical Intelligence"]
[]
Cardiovascular disease is the leading cause of death worldwide, and individuals with diabetes or other cardiometabolic conditions are at increased risk of adverse cardiovascular outcomes. Although advances in prevention and treatment have reduced cardiovascular events globally, cardiometabolic disease continues to repr...
ALL
18 Years
null
false
2026-07-16
2030-07-16
2030-07-16
2026-04-07
2026-04-21
[{"facility": "Hamad Medical Corporation", "city": "Doha", "state": null, "country": "Qatar"}]
false
https://clinicaltrials.gov/study/NCT07515807
2026-05-14T17:51:06.447Z
NCT01847092
A Study in CKD Patients With Type 2 Diabetes Mellitus and Albuminuria
An Exploratory Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel Design Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of AZD1722 in CKD Patients With Type 2 Diabetes Mellitus and Albuminuria
null
Ardelyx
COMPLETED
INTERVENTIONAL
["PHASE2"]
154
Ardelyx
INDUSTRY
["AstraZeneca"]
["Chronic Kidney Disease", "Type 2 Diabetes Mellitus"]
["DRUG: AZD1722", "DRUG: Placebo"]
The purpose of this study is to determine if the study drug is safe, tolerable and active in reducing albuminuria in patients with Chronic Kidney Disease with Type 2 Diabetes.
ALL
18 Years
80 Years
false
2013-05
2015-04
2015-03
2013-05-06
2020-05-27
[{"facility": "Creekside Endocrine Associates PC", "city": "Denver", "state": "Colorado", "country": "United States"}]
true
https://clinicaltrials.gov/study/NCT01847092
2026-05-14T17:51:06.482Z
NCT00958711
The Mechanism of Action of the Unite Biomatrix in Diabetic Foot Ulcer
The Mechanism of Action of the Unite Biomatrix in Diabetic Foot Ulcer
null
Baxter Healthcare Corporation
TERMINATED
INTERVENTIONAL
["NA"]
90
Baxter Healthcare Corporation
INDUSTRY
["Synovis Surgical Innovations"]
["Diabetic Foot Ulcers"]
["DEVICE: Unite Biomatrix", "OTHER: Saline and Gauze"]
The purpose of this study is to assess the mechanism of action of the Unite Biomatrix and compare its performance with the standard of care, saline moistened gauze, for the treatment of diabetic foot ulcers.
ALL
18 Years
null
false
2009-01
2012-05
2012-05
2009-08-13
2019-12-18
[{"facility": "University of California - San Diego", "city": "San Diego", "state": "California", "country": "United States"}, {"facility": "University of Miami, Miller School of Medicine", "city": "Miami", "state": "Florida", "country": "United States"}, {"facility": "Aiyan Diabetes Center", "city": "Evans", "state": ...
true
https://clinicaltrials.gov/study/NCT00958711
2026-05-14T17:51:06.515Z
NCT00198471
Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment
An Open-label Assessment of Intravitreous Injections of Vitrase (Hyaluronidase for Injection) for Inducing Posterior Vitreous Detachment in Subjects With Moderate to Severe Non-proliferative Diabetic Retinopathy
null
Bausch & Lomb Incorporated
COMPLETED
INTERVENTIONAL
["PHASE2"]
10
Bausch & Lomb Incorporated
INDUSTRY
[]
["Vitreous Detachment", "Diabetic Retinopathy"]
["DRUG: Vitrase"]
The purpose of this study is to assess the efficacy of intravitreous injections of Vitrase to induce posterior vitreous detachment(PVD) in subjects with moderate to severe non-proliferative diabetic retinopathy.
ALL
50 Years
null
false
2005-07
2006-11
2006-11
2005-09-20
2013-03-15
[{"facility": "Edgar L. Thomas, MD", "city": "Beverly Hills", "state": "California", "country": "United States"}, {"facility": "Ronni Lieberman, MD", "city": "New York", "state": "New York", "country": "United States"}, {"facility": "Valley Retina Institute, PA", "city": "McAllen", "state": "Texas", "country": "United ...
false
https://clinicaltrials.gov/study/NCT00198471
2026-05-14T17:51:06.551Z
NCT03248271
Effects of Insulin on Hypotension and Sarcopenia
Effects of Insulin on Hypotension and Sarcopenia
null
University of British Columbia
WITHDRAWN
OBSERVATIONAL
[]
0
Kenneth Madden
OTHER
[]
["Diabetes", "Sarcopenia", "Hypotension, Orthostatic"]
["DRUG: Insulin Lispro"]
In this study investigator's aim to determine the impact of insulin therapy on hypotension and sarcopenia
ALL
65 Years
null
null
2017-10-01
2023-01-10
2023-01-10
2017-08-14
2023-01-12
[{"facility": "University of British Columbia - Gerontology Research Lab", "city": "Vancouver", "state": "British Columbia", "country": "Canada"}]
false
https://clinicaltrials.gov/study/NCT03248271
2026-05-14T17:51:06.623Z
NCT01705899
Islet Allotransplantation in Type 1 Diabetes
Islet Allotransplantation in Type 1 Diabetes
null
Ohio State University
SUSPENDED
INTERVENTIONAL
["PHASE1"]
20
Ohio State University
OTHER
[]
["Type 1 Diabetes"]
["DRUG: Human Pancreatic Islets"]
Islet transplantation can provide physiologic insulin replacement to patients with type 1 diabetes without the complications associated with whole pancreas transplantation. The purpose of this study is to achieve insulin-independence in patients with type 1 diabetes, thereby eliminating the need for exogenous insulin i...
ALL
18 Years
65 Years
false
2006-11
2033-10
2033-10
2012-10-12
2025-01-16
[{"facility": "The Ohio State University Medical Center", "city": "Columbus", "state": "Ohio", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT01705899
2026-05-14T17:51:06.662Z
NCT06103799
Application of Information-Motivation-Behavioral Model-based Continuity of Care on the Peri-implantitis Recovery in Diabetic Implant Overdenture Patients
Application of Information-Motivation-Behavioral Model-based Continuity of Care on the Peri-implantitis Recovery in Diabetic Implant Overdenture Patients: A Randomised Controlled Trial
null
The Dental Hospital of Zhejiang University School of Medicine
COMPLETED
INTERVENTIONAL
["NA"]
32
The Dental Hospital of Zhejiang University School of Medicine
OTHER
[]
["Bone Resorption", "Diabetes"]
["BEHAVIORAL: IMB model-based continuity of care"]
The investigators recruited 32 diabetic IOD patients with a total of 110 problematic implants who had completed the treatment for peri-implantitis between January 2021 and March 2023 as research subjects. The patients were randomly assigned to the control group or the experimental group using the random number table. T...
ALL
null
null
false
2023-01-01
2023-09-30
2023-09-20
2023-10-27
2023-10-27
[{"facility": "The Stomatologic Hospital, School of Medicine, Zhejiang University", "city": "Hangzhou", "state": "Zhejiang", "country": "China"}]
false
https://clinicaltrials.gov/study/NCT06103799
2026-05-14T17:51:06.702Z
NCT06474598
An Adaptive Design Study of MTX228
A Open Label, Parallel Group Phase IIA, Adaptive Design Study of MTX228 in Adult Subjects With Type 1 Diabetes and Preserved β-Cell Function
null
University of Alberta
RECRUITING
INTERVENTIONAL
["PHASE2"]
24
University of Alberta
OTHER
[]
["Type 1 Diabetes Mellitus"]
["DRUG: MTX228", "DEVICE: DEXCOM G6"]
MTX228 has been identified as a medication that might allow the re-growth of insulin producing beta cells in people with Type 1 Diabetes. Promoting the re-growth of lost beta cells would be beneficial to people with Type 1 Diabetes because it would allow them to take less insulin by injection and would improve their ov...
ALL
18 Years
65 Years
false
2024-11-14
2027-12
2026-10
2024-06-25
2026-04-13
[{"facility": "University of Alberta", "city": "Edmonton", "state": "Alberta", "country": "Canada"}]
false
https://clinicaltrials.gov/study/NCT06474598
2026-05-14T17:51:06.885Z
NCT05316298
Diabetic Foot Osteomyelitis Treatment Using Gentamicin-loaded Calcium Sulfate-hydroxyapatite Biocomposite
Gentamicin-loaded Calcium Sulfate-hydroxyaPatite Biocomposite to tREat Diabetic Foot Ulcers Complicated by oSteomyElitis: a pRospectiVE Cohort Study
PRESERVE
University Medical Center Groningen
UNKNOWN
OBSERVATIONAL
[]
182
University Medical Center Groningen
OTHER
["Ziekenhuisgroep Twente", "Slingeland Hospital", "Franciscus Gasthuis", "UMC Utrecht", "Rijnstate Hospital", "Jeroen Bosch Ziekenhuis", "Reinier de Graaf Groep", "St. Antonius Hospital", "St Jansdal Hospital", "Maasstad Hospital"]
["Diabetic Foot Ulcer", "Osteomyelitis", "Diabetes Mellitus"]
[]
The amputation risk is high when diabetic foot ulcers, complicated by osteomyelitis, fail to heal after non-surgical standard-of-care treatment. A new treatment regimen has been developed recently and has been proven feasible. This treatment regimen consists of surgical debridement, followed by bone void filling with g...
ALL
18 Years
null
false
2022-12-01
2025-01-01
2025-01-01
2022-04-07
2022-11-16
[{"facility": "Jeroen Bosch Hospital", "city": "'s-Hertogenbosch", "state": null, "country": "Netherlands"}, {"facility": "Hospitalgroup Twente", "city": "Almelo", "state": null, "country": "Netherlands"}, {"facility": "Rijnstate Hospital", "city": "Arnhem", "state": null, "country": "Netherlands"}, {"facility": "Reini...
false
https://clinicaltrials.gov/study/NCT05316298
2026-05-14T17:51:06.927Z
NCT07387393
To Test the Effectiveness and Implementation Approach of a 3-month PILI Pasifika Program Lifestyle Program With Components of Social Determinants of Health Activities in Real-world Settings (Clinical and Non-clinical Settings) Across 3 Years
Peau o le Vasa: Accelerating the Currents of Health Advances for Pasifika People
null
University of Hawaii
NOT_YET_RECRUITING
INTERVENTIONAL
["NA"]
400
University of Hawaii
OTHER
["National Association of Pasifika Organizations", "Papa Ola Lōkahi", "National Heart, Lung, and Blood Institute (NHLBI)"]
["Cardiometabolic Conditions", "Hypertension (HTN)", "Dyslipidemia", "Pre-diabetes", "Type 2 Diabetes Mellitus (T2DM)", "Overweight (BMI > 25)", "Weight Loss Trial"]
["BEHAVIORAL: PILI (Partnership for Improving Lifestyle Intervention) Pasifika Program"]
In this study, the investigators are conducting a Type 3 hybrid effectiveness-implementation trial to evaluate the implementation of the Community Health Workers (CHW)-delivered PILI Pasifika Program (PPP) across 3 regions, the U.S. Affiliated Pacific Islands (USAPI), the continental U.S., and Hawai'i, among 400 Native...
ALL
18 Years
null
false
2026-05-01
2028-10-31
2028-09-15
2026-02-04
2026-04-22
[{"facility": "National Association of Pasifika Organizations", "city": "Fayetteville", "state": "Arkansas", "country": "United States"}, {"facility": "Papa Ola Lokahi", "city": "Honolulu", "state": "Hawaii", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT07387393
2026-05-14T17:51:06.994Z
NCT00408993
Duloxetine Versus Placebo in the Treatment of Patients With Diabetic Peripheral Neuropathic Pain in China
Duloxetine Versus Placebo in the Treatment of Patients With Diabetic Peripheral Neuropathic Pain in China
null
Eli Lilly and Company
COMPLETED
INTERVENTIONAL
["PHASE3"]
215
Eli Lilly and Company
INDUSTRY
["Boehringer Ingelheim"]
["Diabetic Neuropathies"]
["DRUG: Duloxetine Hydrochloride", "DRUG: Placebo"]
To determine if duloxetine 60mg up to 120mg daily can work in treating pain from Diabetic Neuropathy.
ALL
18 Years
null
false
2006-12
2008-02
2008-02
2006-12-08
2011-07-26
[{"facility": "For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.", "city": "Beijing", "state": null, "country": "China"}, {"facility": "...
true
https://clinicaltrials.gov/study/NCT00408993
2026-05-14T17:51:07.038Z
NCT01002521
Wound Healing In Diabetes (WHy) Study
Molecular and Genetic Analysis of Disturbed Wound Healing in Barbadians With Diabetic Foot Ulcers
WHy
The University of The West Indies
UNKNOWN
OBSERVATIONAL
[]
605
The University of The West Indies
OTHER
["Chronic Disease Research Centre", "Barbados Diabetes Foundation"]
["Impaired Wound Healing", "Diabetes Mellitus"]
[]
This observational study aims to identify risk factors and molecular mechanisms of impaired wound healing, to guide better foot care in the diabetic population.
ALL
null
null
false
2009-12
2012-06
2011-06
2009-10-27
2009-10-27
[{"facility": "Chronic Disease Research Centre", "city": "Bridgetown", "state": "Saint Michael", "country": "Barbados"}]
false
https://clinicaltrials.gov/study/NCT01002521
2026-05-14T17:51:07.083Z
NCT00001733
Screening for Studies on Retinovascular Diseases
Screening Study for the Evaluation and Diagnosis of Potential Research Subjects With Retinovascular Diseases
null
National Institutes of Health Clinical Center (CC)
COMPLETED
OBSERVATIONAL
[]
2,000
National Eye Institute (NEI)
NIH
[]
["Diabetic Retinopathy", "Macular Degeneration", "Pathologic Neovascularization", "Retinal Disease"]
[]
This screening protocol is designed to help recruit patients for National Eye Institute (NEI) studies of the retina, such as diabetic retinopathy and macular degeneration. Patients must meet the specific criteria of a research study, and this protocol serves as a first step for admitting patients to a retinal disease s...
ALL
18 Years
null
true
1998-03-06
2008-07-02
null
1999-11-04
2017-07-02
[{"facility": "National Institutes of Health Clinical Center, 9000 Rockville Pike", "city": "Bethesda", "state": "Maryland", "country": "United States"}]
false
https://clinicaltrials.gov/study/NCT00001733
2026-05-14T17:51:07.102Z
End of preview. Expand in Data Studio

ClinicalTrials.gov Scraper

Scrape clinical trials from the official ClinicalTrials.gov API — no login, no API key, no blocking. 585K+ studies with status, phase, sponsor, conditions, interventions, enrollment, eligibility and locations. Filter by condition, sponsor and status. Tens of thousands per run.

What the actor scrapes

🔬 ClinicalTrials.gov Scraper — Clinical Trial Data from the Official API Scrape clinical trials straight from the official ClinicalTrials.gov API — no login, no API key, no blocking. This Apify Actor covers the full ClinicalTrials.gov database of 585,000+ studies worldwide, returning deep structured data: trial status, phase, sponsor, conditions, interventions, enrollment, eligibility, locations, and key dates. One run can return tens of thousands of trials. If you need bulk **clin

Who this is for

This sample is useful for anyone working in gov data, automation, developer tools who wants a quick look at the shape of the data before running the live actor at scale. Treat it as a static snapshot — counts, prices and timestamps reflect the moment the sample was captured and will drift over time.

Source

Live source: This dataset is a static sample. For fresh, customizable extractions, run the live Apify actor: logiover/clinicaltrials-gov-scraper

Fields

  • nctId — identifier
  • briefTitle — field captured by the actor
  • officialTitle — field captured by the actor
  • acronym — field captured by the actor
  • organization — field captured by the actor
  • overallStatus — field captured by the actor
  • studyType — field captured by the actor
  • phases — field captured by the actor
  • enrollmentCount — numeric count
  • leadSponsor — field captured by the actor
  • sponsorClass — field captured by the actor
  • collaborators — field captured by the actor
  • conditions — field captured by the actor
  • interventions — field captured by the actor
  • briefSummary — field captured by the actor
  • sex — field captured by the actor
  • minimumAge — field captured by the actor
  • maximumAge — field captured by the actor
  • healthyVolunteers — field captured by the actor
  • startDate — timestamp
  • completionDate — timestamp
  • primaryCompletionDate — timestamp
  • firstPostedDate — timestamp
  • lastUpdatePostedDate — timestamp
  • locations — field captured by the actor
  • hasResults — boolean flag
  • url — canonical URL of the item
  • scrapedAt — timestamp the row was scraped

Sample preview

[
  {
    "nctId": "NCT01213784",
    "briefTitle": "Optimized Glycemic Control in Heart Failure Patients With DM2:\"Effect on Left Ventricular Function and Skeletal Muscle\"",
    "officialTitle": "Optimized Glycemic Control in Type 2 Diabetics With Heart Failure:\"Effect on Left Ventricular Function and Skeletal Muscle\"",
    "acronym": "HFDM",
    "organization": "University of Aarhus",
    "overallStatus": "COMPLETED",
    "studyType": "INTERVENTIONAL",
    "phases": [
      "PHASE2"
    ],
    "enrollmentCount": 40,
    "leadSponsor": "University of Aarhus",
    "sponsorClass": "OTHER",
    "collaborators": [
      "The Danish Diabetes Association"
    ],
    "conditions": [
      "Type 2 Diabetes",
      "Heart Failure"
    ],
    "interventions": [
      "OTHER: all antidiabetic drugs will be appliable"
    ],
    "briefSummary": "The investigators wish to investigate wether a more strict diabetic control improves cardiac function, muscle strength, exercise capacity and decreases symptoms.\n\nThe investigators hypothesis is that improving the glycemic control in suboptimized diabetics with heart failure will improve cardiac performance, muscle strength, exercise capacity and decrease symptoms.",
    "sex": "ALL",
    "minimumAge": "18 Years",
    "maximumAge": "90 Years",
    "healthyVolunteers": false,
    "startDate": "2010-09",
    "completionDate": "2012-11",
    "primaryCompletionDate": "2012-11",
    "firstPostedDate": "2010-10-04",
    "lastUpdatePostedDate": "2015-03-06",
    "locations": [
      {
        "facility": "Dept. of cardiology, Aarhus university hospital Skejby",
        "city": "Aarhus",
        "state": "Central Jutland",
        "country": "Denmark"
      }
    ],
    "hasResults": false,
    "url": "https://clinicaltrials.gov/study/NCT01213784",
    "scrapedAt": "2026-05-14T17:51:03.369Z"
  },
  {
    "nctId": "NCT03060538",
    "briefTitle": "A Multiple Ascending Dose Study to Evaluate Safety and Tolerability of BFKB8488A in Participants With Type 2 Diabetes Mellitus and Participants With Non-Alcoholic Fatty Liver Disease",
    "officialTitle": "A Phase Ib, Randomized, Blinded, Placebo-Controlled, Multiple Ascending-Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Subcutaneous BFKB8488A in Patients With Type 2 Diabetes Mellitus and Patients With Non-Alcoholic Fatty Liver Disease",
    "acronym": null,
    "organization": "Genentech, Inc.",
    "overallStatus": "COMPLETED",
    "studyType": "INTERVENTIONAL",
    "phases": [
      "PHASE1"
    ],
    "enrollmentCount": 154,
    "leadSponsor": "Genentech, Inc.",
    "sponsorClass": "INDUSTRY",
    "collaborators": [],
    "conditions": [
      "Diabetes Mellitus, Type 2",
      "Non-Alcoholic Fatty Liver Disease"
    ],
    "interventions": [
      "DRUG: BFKB8488A",
      "OTHER: Placebo"
    ],
    "briefSummary": "This is a Phase Ib, randomized, blinded, placebo-controlled, multiple ascending-dose study of the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) effects of BFKB8488A in participants with Type 2 diabetes mellitus (T2DM) and participants with non-alcoholic fatty liver disease(NAFLD). A maximum of approximately 160 participants will be enrolled across multiple sites in the Unite…",
    "sex": "ALL",
    "minimumAge": "18 Years",
    "maximumAge": "75 Years",
    "healthyVolunteers": false,
    "startDate": "2017-03-05",
    "completionDate": "2019-12-13",
    "primaryCompletionDate": "2019-12-13",
    "firstPostedDate": "2017-02-23",
    "lastUpdatePostedDate": "2020-03-27",
    "locations": [
      {
        "facility": "Pinnacle Research Group Cullman",
        "city": "Anniston",
        "state": "Alabama",
        "country": "United States"
      },
      {
        "facility": "Pinnacle Research Group; Llc, Central",
        "city": "Anniston",
        "state": "Alabama",
        "country": "United States"
      },
      {
        "facility": "Southern California Research Center, Inc.",
        "city": "Coronado",
        "state": "California",
        "country": "United States"
      },
      {
        "facility": "Stanford Health Care",
        "city": "Stanford",
        "state": "California",
        "country": "United States"
      },
      {
        "facility": "Diabetes Research Center",
        "city": "Tustin",
        "state": "California",
        "country": "United States"
      }
    ],
    "hasResults": false,
    "url": "https://clinicaltrials.gov/study/NCT03060538",
    "scrapedAt": "2026-05-14T17:51:03.463Z"
  }
]

Snapshot stats

  • Row count in this sample: 100
  • Data quality flag at capture time: EXISTING_USED

License & Attribution

Released under Creative Commons Attribution 4.0 (CC BY 4.0). If you use this data, please credit the source actor and link back to its Apify Store page: logiover/clinicaltrials-gov-scraper.

The sample is provided as-is for evaluation and research. Source websites retain their own terms of service — downstream users are responsible for complying with them when running the live actor or redistributing scraped content.

Downloads last month
32