Datasets:
question_id stringlengths 24 24 | question stringlengths 13 215 | answer stringlengths 2 3.15k | relevant_passage_ids sequencelengths 1 157 | type stringclasses 4
values | snippets listlengths 1 121 |
|---|---|---|---|---|---|
55031181e9bde69634000014 | Is Hirschsprung disease a mendelian or a multifactorial disorder? | Coding sequence mutations in RET, GDNF, EDNRB, EDN3, and SOX10 are involved in the development of Hirschsprung disease. The majority of these genes was shown to be related to Mendelian syndromic forms of Hirschsprung's disease, whereas the non-Mendelian inheritance of sporadic non-syndromic Hirschsprung disease proved ... | [
"15858239",
"20598273",
"15829955",
"6650562",
"12239580",
"21995290",
"15617541",
"23001136",
"8896569"
] | summary | [
{
"offsetInBeginSection": 131,
"offsetInEndSection": 358,
"text": "Hirschsprung disease (HSCR) is a multifactorial, non-mendelian disorder in which rare high-penetrance coding sequence mutations in the receptor tyrosine kinase RET contribute to risk in combination with mutations at other genes",
"be... |
55046d5ff8aee20f27000007 | List signaling molecules (ligands) that interact with the receptor EGFR? | The 7 known EGFR ligands are: epidermal growth factor (EGF), betacellulin (BTC), epiregulin (EPR), heparin-binding EGF (HB-EGF), transforming growth factor-α [TGF-α], amphiregulin (AREG) and epigen (EPG). | [
"23959273",
"21514161",
"23787814",
"23888072",
"23821377",
"24124521",
"22260327",
"24204699",
"24323361",
"23089711",
"23399900",
"23382875",
"23729230",
"23212918",
"23099994",
"22247333"
] | list | [
{
"offsetInBeginSection": 1085,
"offsetInEndSection": 1199,
"text": "the epidermal growth factor receptor (EGFR) ligands, such as epidermal growth factor (EGF) and amphiregulin (AREG)",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/24323361",
"endSection": "abst... |
54e25eaaae9738404b000017 | Is the protein Papilin secreted? | Yes, papilin is a secreted protein | [
"3320045",
"7515725",
"20805556",
"19297413",
"19724244",
"15094122",
"12666201",
"21784067",
"11076767",
"15094110"
] | yesno | [
{
"offsetInBeginSection": 1085,
"offsetInEndSection": 1307,
"text": "Using expression analysis, we identify three genes that are transcriptionally regulated by HLH-2: the protocadherin cdh-3, and two genes encoding secreted extracellular matrix proteins, mig-6/papilin and him-4/hemicentin. ",
"begin... |
535d292a9a4572de6f000003 | Are long non coding RNAs spliced? | Long non coding RNAs appear to be spliced through the same pathway as the mRNAs | [
"22955988",
"22955974",
"24285305",
"22707570",
"21622663",
"24106460"
] | yesno | [
{
"offsetInBeginSection": 546,
"offsetInEndSection": 739,
"text": "Our analyses indicate that lncRNAs are generated through pathways similar to that of protein-coding genes, with similar histone-modification profiles, splicing signals, and exon/intron lengths.",
"beginSection": "abstract",
"docu... |
55262a9787ecba3764000009 | Is RANKL secreted from the cells? | Receptor activator of nuclear factor κB ligand (RANKL) is a cytokine predominantly secreted by osteoblasts. | [
"22948539",
"23698708",
"23827649",
"22901753",
"21618594",
"23835909",
"23632157",
"24265865",
"24267510",
"22867712"
] | yesno | [
{
"offsetInBeginSection": 114,
"offsetInEndSection": 242,
"text": "Osteoprotegerin (OPG) is a soluble secreted factor that acts as a decoy receptor for receptor activator of NF-κB ligand (RANKL) ",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/24267510",
"endSec... |
51406e6223fec90375000009 | Does metformin interfere thyroxine absorption? | No. There are not reported data indicating that metformin reduce with thyroxine absorption. | [
"26191653"
] | yesno | [
{
"offsetInBeginSection": 1418,
"offsetInEndSection": 1481,
"text": "LT4 absorption is unchanged by concomitant metformin ingestion.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/26191653",
"endSection": "abstract"
},
{
"offsetInBeginSection": 125,
... |
553fa78b1d53b76422000007 | Which miRNAs could be used as potential biomarkers for epithelial ovarian cancer? | miR-200a, miR-100, miR-141, miR-200b, miR-200c, miR-203, miR-510, miR-509-5p, miR-132, miR-26a, let-7b, miR-145, miR-182, miR-152, miR-148a, let-7a, let-7i, miR-21, miR-92 and miR-93 could be used as potential biomarkers for epithelial ovarian cancer. | [
"21345725",
"22246341",
"23888941",
"23836287",
"23542579",
"20035894",
"19074899",
"23978303",
"18954897",
"21571355",
"21971665",
"23918241",
"23272653",
"23621186"
] | list | [
{
"offsetInBeginSection": 1010,
"offsetInEndSection": 1388,
"text": "Finally, five promising differentially miRNAs (miR-200a, miR-100, miR-141, miR-200b, and miR-200c) were reported with the consistent direction in four or more studies. MiR-200a, miR-200b, miR-200c, and miR-141, all of them belong to mi... |
5149199dd24251bc05000040 | Which acetylcholinesterase inhibitors are used for treatment of myasthenia gravis? | Pyridostigmine and neostygmine are acetylcholinesterase inhibitors that are used as first-line therapy for symptomatic treatment of myasthenia gravis. Pyridostigmine is the most widely used acetylcholinesterase inhibitor. Extended release pyridotsygmine and novel acetylcholinesterase inhibitors inhibitors with oral ant... | [
"21815707",
"21845054",
"21328290",
"20663605",
"21133188",
"15610702"
] | list | [
{
"offsetInBeginSection": 1251,
"offsetInEndSection": 1321,
"text": "Pyridostigmine is the most widely used acetylcholinesterase inhibitor.",
"beginSection": "sections.0",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/21133188",
"endSection": "sections.0"
},
{
"offsetInBeginSection... |
52bf1db603868f1b06000011 | Has Denosumab (Prolia) been approved by FDA? | Yes, Denosumab was approved by the FDA in 2010. | [
"24126422",
"22826702",
"23759273",
"24114694",
"21129866",
"23956508",
"22716221",
"23757624",
"23367751",
"22074657",
"21785279",
"21113693",
"21942303",
"22540167",
"24308016",
"21208140",
"23652187",
"21170699",
"21470540",
"24316116",
"20811384"
] | yesno | [
{
"offsetInBeginSection": 12,
"offsetInEndSection": 177,
"text": "Denosumab is a RANK-ligand antibody that was approved by the FDA in 2010 for the prevention of skeletal fractures in patients with bone metastases from solid tumors.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.n... |
5709e4b2cf1c32585100001c | List the human genes encoding for the dishevelled proteins? | DVL-1
DVL-2
DVL-3 | [
"12883684",
"24040443",
"19618470",
"8817329",
"8856345",
"23836490",
"8149913",
"7958461",
"16457155"
] | list | [
{
"offsetInBeginSection": 294,
"offsetInEndSection": 516,
"text": "Dishevelled (Dvl/Dsh) is a multi-module protein and a key regulator of both the canonical Wnt and the PCP pathway. In mouse, all Dvl1(-/-) ; Dvl2(-/-) double mutants display craniorachischisis, a severe form of open NTDs. ",
"beginSe... |
56bc751eac7ad10019000013 | Name synonym of Acrokeratosis paraneoplastica. | Acrokeratosis paraneoplastic (Bazex syndrome) is a rare, but distinctive paraneoplastic dermatosis characterized by erythematosquamous lesions located at the acral sites and is most commonly associated with carcinomas of the upper aerodigestive tract. | [
"3819049",
"18775590",
"22146896",
"6225397",
"18672707",
"7796616",
"16435144",
"7640201",
"22252191",
"17097409",
"17374318",
"22470801",
"8949310",
"1521479",
"1433123"
] | factoid | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 154,
"text": "Acrokeratosis paraneoplastica of Bazex is a rare but important paraneoplastic dermatosis, usually manifesting as psoriasiform rashes over the acral sites.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubme... |
54d4e03a3706e89528000001 | Which are the classes of anti-arrhythmic drugs according to Vaughan-Williams classification? | Antiarrhythmic drugs can be divided into four Vaughan Williams classes (I-IV). Class I antiarrhythmic agents have as a common action, blockade of the sodium channels. Class II agents are antisympathetic drugs, particularly the beta-adrenoceptor blockers. Class-III antiarrhythmics have as a common action the potassium-c... | [
"9803978",
"11564050",
"1290288",
"7875632",
"10810787"
] | list | [
{
"offsetInBeginSection": 491,
"offsetInEndSection": 577,
"text": "Class II agents are antisympathetic drugs, particularly the beta-adrenoceptor blockers",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/9803978",
"endSection": "abstract"
},
{
"offsetInBeg... |
55072c803b8a5dc045000001 | Which are the different isoforms of the mammalian Notch receptor? | Notch signaling is an evolutionarily conserved mechanism, used to regulate cell fate decisions. Four Notch receptors have been identified in man: Notch-1, Notch-2, Notch-3 and Notch-4. | [
"23028706",
"21639801",
"11532344",
"22842086",
"21356309",
"11732008",
"16307184"
] | list | [
{
"offsetInBeginSection": 346,
"offsetInEndSection": 597,
"text": "Here, we investigate protein interactions between NOTCH3 and other vascular Notch isoforms and characterize the effects of elevated NOTCH3 on smooth muscle gene regulation. We demonstrate that NOTCH3 forms heterodimers with NOTCH1, NOTCH... |
53061af558348c0f52000002 | Which are the major characteristics of cellular senescence? | The defining characteristics of cellular senescence are altered morphology, arrested cell-cycle progression, development of aberrant gene expression with proinflammatory behavior, and telomere shortening. | [
"9624027",
"18976161",
"8824885"
] | list | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 272,
"text": "Cellular senescence is recognized as a critical cellular response to prolonged rounds of replication and environmental stresses. Its defining characteristics are arrested cell-cycle progression and the development of aberrant gene expressi... |
56c1f01def6e394741000045 | Orteronel was developed for treatment of which cancer? | Orteronel was developed for treatment of castration-resistant prostate cancer. | [
"24799061",
"24418642",
"25537627",
"25701170",
"25624429",
"25264242",
"21978946",
"26150028",
"24100689"
] | factoid | [
{
"offsetInBeginSection": 225,
"offsetInEndSection": 395,
"text": "Pooled-analysis was also performed, to assess the effectiveness of agents targeting the androgen axis via identical mechanisms of action (abiraterone acetate, orteronel).",
"beginSection": "abstract",
"document": "http://www.ncbi... |
5313b049e3eabad021000013 | Is the monoclonal antibody Trastuzumab (Herceptin) of potential use in the treatment of prostate cancer? | Although is still controversial, Trastuzumab (Herceptin) can be of potential use in the treatment of prostate cancer overexpressing HER2, either alone or in combination with other drugs. | [
"23294030",
"10473102",
"11786427",
"17210707",
"21364123",
"12173324",
"22322558",
"16163160",
"11236029",
"10519379",
"15264245",
"20716957",
"11502465",
"15046685",
"17211467",
"11920466",
"17142577",
"11685722",
"21844010",
"18038879",
"12677892",
"15036648",
"1557196... | yesno | [
{
"offsetInBeginSection": 9,
"offsetInEndSection": 161,
"text": "Herceptin is widely used in treating Her2-overexpressing breast cancer. However, the application of Herceptin in prostate cancer is still controversial.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/... |
53137541e3eabad021000010 | Which are the Yamanaka factors? | The Yamanaka factors are the OCT4, SOX2, MYC, and KLF4 transcription factors | [
"21761058",
"21839145",
"23612755",
"23658991",
"23939864",
"22357549",
"20144262",
"23527808",
"24150221",
"21640101",
"19030024",
"23704989",
"22449255",
"22075965",
"21249204",
"23166588"
] | list | [
{
"offsetInBeginSection": 462,
"offsetInEndSection": 505,
"text": "Yamanaka factors (OCT4, SOX2, MYC, and KLF4",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/23704989",
"endSection": "abstract"
},
{
"offsetInBeginSection": 17,
"offsetInEndSection": ... |
515aa0abd24251bc050000a8 | What is the aim of the Human Chromosome-centric Proteome Project (C-HPP)? | The chromosome-centric human proteome project aims to systematically map all human proteins, chromosome by chromosome, in a gene-centric manner through dedicated efforts from national and international teams | [
"23312004",
"23253012",
"23252913",
"22966780",
"23249167",
"23259496",
"21742803",
"23205526",
"23234512",
"23308364",
"23214983",
"23276153",
"23153008",
"23227862",
"22443261"
] | summary | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 144,
"text": "The Chromosome-Centric Human Proteome Project (C-HPP) is an international effort for creating an annotated proteomic catalog for each chromosome",
"beginSection": "sections.0",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/233120... |
56af9f130a360a5e45000015 | Where is the protein Pannexin1 located? | The protein Pannexin1 is localized to the plasma membranes. | [
"24642372",
"25056878",
"24694658",
"25698922",
"17064878",
"24782784",
"26100513",
"25007779",
"19409451",
"24194896"
] | factoid | [
{
"offsetInBeginSection": 394,
"offsetInEndSection": 620,
"text": "zfPanx1 was identified on the surface of horizontal cell dendrites invaginating deeply into the cone pedicle near the glutamate release sites of the cones, providing in vivo evidence for hemichannel formation at that location.",
"beg... |
5718bbb37de986d80d00000b | Which currently known mitochondrial diseases have been attributed to POLG mutations? | Mutations in the POLG gene have emerged as one of the most common causes of inherited mitochondrial disease in children and adults. They are responsible for a heterogeneous group of at least 6 major phenotypes of neurodegenerative disease that include: 1) childhood Myocerebrohepatopathy Spectrum disorders (MCHS), 2) Al... | [
"18546365",
"12825077",
"22647225",
"15351195",
"20927567"
] | list | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 576,
"text": "Mutations in the POLG gene have emerged as one of the most common causes of inherited mitochondrial disease in children and adults. They are responsible for a heterogeneous group of at least 6 major phenotypes of neurodegenerative disease ... |
532f062ad6d3ac6a34000027 | What is the effect of ivabradine in heart failure after myocardial infarction? | Ιvabradine decreases heart rate and reduces myocardial oxygen demand, increases diastolic perfusion time and improves energetics in ischemic myocardium. Ivabradine protects the myocardium during ischemia, improves left ventricular function in heart failure and reduces remodeling following myocardial infarction. It impr... | [
"21838751",
"19074674",
"18310678",
"23067195",
"18757088",
"20000882",
"19664404",
"14981003",
"23096376",
"21878041",
"19514618",
"22416440",
"19129742",
"23536611",
"18621770",
"19411283",
"20028694",
"23394554"
] | summary | [
{
"offsetInBeginSection": 1290,
"offsetInEndSection": 1515,
"text": "Ivabradine may be important for the improvement of clinical outcomes in patients with LV systolic dysfunction and heart rate ≥ 70 b.p.m., whatever the primary clinical presentation (CAD or HF) or clinical status (NYHA class).",
"be... |
52bf1b0a03868f1b06000009 | What is the mode of inheritance of Wilson's disease? | Wilson's disease (WD) is an autosomal recessive disorder. | [
"838566",
"8615372",
"12152840",
"1940586",
"6109943",
"1248830",
"22610954",
"2724779",
"14580665",
"20662462",
"759736",
"8186659",
"6620327",
"16932613"
] | factoid | [
{
"offsetInBeginSection": 122,
"offsetInEndSection": 272,
"text": "The disease has an autosomal recessive mode of inheritance, and is characterized by excessive copper deposition, predominantly in the liver and brain.",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/... |
517395b98ed59a060a00001a | Are transcription and splicing connected? | Yes. There is strong evidence that splicing and transcription are intimately coupled in metazoans, with genome wide surveys show that most splicing occurs during transcription. Chromatin structure, RNA polymerase dynamics, and recruitment of splicing factors through the transcriptional machinery are factors that expla... | [
"20808788",
"23074139",
"23097425",
"17189193",
"21964334",
"16921380",
"15870275",
"22479188",
"22975042",
"15905409",
"21095588",
"16172632",
"15383674",
"22156210",
"23209445",
"16769980"
] | yesno | [
{
"offsetInBeginSection": 476,
"offsetInEndSection": 791,
"text": ", as splicing is often cotranscriptional, a complex picture emerges in which splicing regulation not only depends on the balance of splicing factor binding to their pre-mRNA target sites but also on transcription-associated features such... |
52bf19c503868f1b06000001 | What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)? | Facioscapulohumeral muscular dystrophy has an autosomal dominant inheritance pattern. | [
"10487912",
"15307599",
"10969520",
"19248726",
"10864616",
"23143600",
"22551571",
"22525183",
"7739631",
"21795275",
"23573591"
] | factoid | [
{
"offsetInBeginSection": 214,
"offsetInEndSection": 238,
"text": "autosomal dominant FSHD1",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/23143600",
"endSection": "abstract"
},
{
"offsetInBeginSection": 0,
"offsetInEndSection": 206,
"text": "Fa... |
54db1d580f63c58e6e000005 | Is Alu hypomethylation associated with breast cancer? | Yes, Alu elements were found to be hypomethylated in breast cancer, especially in the HER2-enriched subtype. Furthermore, Alu hypomethylation was identified as a late event during breast cancer progression, and in invasive breast cancer, tended to be associated with negative estrogen receptor status and poor disease-fr... | [
"20682973",
"24971511"
] | yesno | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 88,
"text": "Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/24971511",
"endSection": "title"
},
{
"offsetInBeginSect... |
54f9d3eedd3fc62544000004 | Which proteins participate in the formation of the ryanodine receptor quaternary macromolecular complex? | Junctin is a major transmembrane protein in cardiac junctional sarcoplasmic reticulum, which forms a quaternary complex with the ryanodine receptor (Ca(2+) release channel), triadin, and calsequestrin. | [
"12909320",
"11069905",
"15205169",
"22298808",
"22025663",
"18620751",
"18206802",
"16289269",
"15731387",
"14638677",
"9287354",
"22427521"
] | list | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 246,
"text": "Calsequestrin (CSQ) is a Ca(2+) storage protein that interacts with triadin (TRN), the ryanodine receptor (RyR), and junctin (JUN) to form a macromolecular tetrameric Ca(2+) signaling complex in the cardiac junctional sarcoplasmic reticulu... |
5505edac8e1671127b000005 | What kind of chromatography is HILIC? | Hydrophilic Interaction Chromatography (HILIC) | [
"21737084",
"23217321",
"22946920",
"23073287",
"21238772",
"21316059"
] | factoid | [
{
"offsetInBeginSection": 2,
"offsetInEndSection": 96,
"text": "hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC LC-MS/MS) method",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/23217321",
"endSection": "abstract"
},
{
"offse... |
5160193d298dcd4e51000039 | What is the effect of TRH on myocardial contractility? | TRH improves myocardial contractility | [
"9225129",
"1979356",
"9088928",
"15096458",
"2848686",
"1611701"
] | summary | [
{
"offsetInBeginSection": 876,
"offsetInEndSection": 1078,
"text": "Acute intravenous administration of TRH to rats with ischemic cardiomyopathy caused a significant increase in heart rate, mean arterial pressure, cardiac output, stroke volume, and cardiac contractility",
"beginSection": "sections.0... |
51593dc8d24251bc05000099 | Proteomic analyses need prior knowledge of the organism complete genome. Is the complete genome of the bacteria of the genus Arthrobacter available? | Yes, the complete genome sequence of Arthrobacter (two strains) is deposited in GenBank. | [
"28904741",
"28450506",
"21677849",
"28315371",
"23039946",
"28642378",
"28138355"
] | yesno | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 80,
"text": "Complete genome sequence of Arthrobacter phenanthrenivorans type strain (Sphe3).",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/21677849",
"endSection": "title"
},
{
"offsetInBeginSection": 0,... |
56e2cec751531f7e33000015 | What is the structural fold of bromodomain proteins? | The structure fold of the bromodomains is an all-alpha-helical fold, which includes a left-handed four-helix bundle topology, with two short additional helices in a long connecting loop. | [
"17498659",
"10365964",
"17848202",
"17694091",
"10827952",
"17582821",
"11090279",
"17274598",
"17148447"
] | factoid | [
{
"offsetInBeginSection": 780,
"offsetInEndSection": 1028,
"text": "These new studies also support the notion that functional diversity of a conserved bromodomain structural fold is achieved by evolutionary changes of structurally flexible amino-acid sequences in the ligand binding site such as the ZA a... |
515deafd298dcd4e51000025 | List the endoscopic diagnoses that have been reported in children with autism | Endoscopic examinations in autistic children have been reported to show : I or II reflux esophagitis, Achalasia, chronic gastritis and chronic duodenitis, mild acute and chronic inflammation of the small bowel and colorectum and Ileo-colonic lymphoid nodular hyperplasia (LNH).
The number of Paneth's cells in the du... | [
"11007230",
"22607127",
"16003132",
"9585670",
"10547242",
"12907332"
] | list | [
{
"offsetInBeginSection": 0,
"offsetInEndSection": 69,
"text": "Autism and esophageal achalasia in childhood: a possible correlation?",
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/22607127",
"endSection": "title"
},
{
"offsetInBeginSection": 801,
"off... |
532624ae600967d132000005 | What are the outcomes of Renal sympathetic denervation? | Significant decreases and progressively higher reductions of systolic and diastolic blood pressure were observed after RSD. The complication rate was minimal.
Renal sympathetic denervation also reduces heart rate, which is a surrogate marker of cardiovascular risk. | [
"21247927",
"22573363",
"23176687",
"23541665",
"23774592",
"24029963",
"23890950",
"23514712",
"23819768"
] | summary | [
{
"offsetInBeginSection": 544,
"offsetInEndSection": 703,
"text": "Significant decreases and progressively higher reductions of systolic and diastolic blood pressure were observed after RSD. The complication rate was minimal. ",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.go... |
5518e7da622b194345000004 | Which MAP kinase phosphorylates the transcription factor c-jun? | c-Jun is phosphorylated by c-Jun NH2-terminal kinase (JNK). | [
"24113186",
"24300195",
"24272171",
"24291243",
"24252081",
"15228586",
"23028407",
"24285252",
"23385061",
"24321566",
"23147205",
"8607977",
"24139673",
"24321066",
"15637069",
"24270002",
"24144051",
"15708845"
] | factoid | [
{
"offsetInBeginSection": 955,
"offsetInEndSection": 987,
"text": " c-Jun NH2-terminal kinase (JNK)",
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/24321566",
"endSection": "abstract"
},
{
"offsetInBeginSection": 213,
"offsetInEndSection": 294,
"... |
530a5117970c65fa6b000007 | What is the meaning of the acronym "TAILS" used in protein N-terminomics? | TAILS stands for "Terminal Amine Isotopic Labeling of Substrates" | [
"20305284",
"21604127",
"22577022",
"21604129",
"23667905",
"22367194"
] | factoid | [
{
"offsetInBeginSection": 127,
"offsetInEndSection": 305,
"text": ". It is important to identify what proteins are substrates of proteases and where their cleavage sites are so as to reveal the molecular mechanisms and specificity of signaling. ",
"beginSection": "abstract",
"document": "http://... |
56bf365eef6e39474100000e | Do mutations of AKT1 occur in meningiomas? | Yes, AKT1 mutation occurs in meningiomas. | [
"25146167",
"23475883",
"23348505",
"23334667",
"24096618",
"25857641"
] | yesno | [
{
"offsetInBeginSection": 921,
"offsetInEndSection": 1122,
"text": "The recent identification of somatic mutations in components of the SHH-GLI1 and AKT1-MTOR signaling pathways indicates the potential for cross talk of these pathways in the development of meningiomas.",
"beginSection": "abstract",
... |
BioASQ 12B RAG Dataset
A processed version of the BioASQ 12B dataset optimized for Retrieval-Augmented Generation (RAG) applications in biomedical question answering.
This dataset contains two distinct subsets specifically designed for RAG applications:
A text corpus of PubMed abstracts ready for indexing and retrieval, containing detailed metadata and full abstract text.
An evaluation dataset consisting of biomedical questions, each paired with an ideal answer and a list of passage IDs that are relevant to answering the question.
This structure makes it ideal for building and evaluating RAG systems that retrieve relevant biomedical information from a corpus and generate accurate, evidence-based answers to complex biomedical questions.
The code to generate this dataset is here: https://github.com/MattMorgis/bioasq-rag
Dataset Structure
The dataset contains three main components:
Corpus (
data/corpus.jsonl): A collection of PubMed abstracts including metadata.- The corpus is accessible through the "train" split of the "text-corpus" config
- Each document contains:
id: PubMed IDtitle: Title of the papertext: Abstract texturl: PubMed URLpublication_date: Publication datejournal: Journal nameauthors: List of authorsdoi: Digital Object Identifier (if available)keywords: Keywordsmesh_terms: MeSH terms
Dev Questions (
data/dev.jsonl): Development set of biomedical questions.- The dev questions are accessible through the "dev" split of the "question-answer-passages" config
- Each question contains:
question_id: Unique identifier for the questionquestion: The question textanswer: Ideal answerrelevant_passage_ids: List of PubMed IDs for relevant abstractstype: Question type (e.g., factoid, list, yes/no, summary)snippets: Relevant snippets from abstracts
Eval Questions (
data/eval.jsonl): Eval set of biomedical questions.- Same structure as dev questions, accessible through the "eval" split
Usage
This dataset is designed for training and evaluating RAG systems for biomedical question answering.
Loading the Dataset
You can load the dataset using the Hugging Face datasets library. Note that you must specify a config name:
from datasets import load_dataset
# Load the corpus of PubMed abstracts
corpus_dataset = load_dataset("mattmorgis/bioasq-12b-rag", "text-corpus")
# Load the question-answer dataset
questions_dataset = load_dataset("mattmorgis/bioasq-12b-rag", "question-answer-passages")
# Access the corpus data (note: the corpus is stored in the "train" split)
corpus_docs = corpus_dataset["train"]
# Access the development questions
dev_questions = questions_dataset["dev"]
# Access the eval questions
eval_questions = questions_dataset["eval"]
Example RAG Application
This dataset can be used to build a biomedical RAG system:
- Index the corpus using a vector database (e.g., FAISS, Chroma)
- Embed questions using a biomedical or general purpose text embedding model
- Retrieve relevant documents from the corpus based on question embeddings
- Generate answers using a large language model (LLM) with the retrieved context
Evaluation
The dataset provides gold standard answers and relevant passage IDs that can be used to evaluate:
- Retrieval accuracy
- Answer quality
- Domain-specific knowledge incorporation
Source
This dataset is derived from the BioASQ Challenge task 12b dataset.
Anastasia Krithara, Anastasios Nentidis, Konstantinos Bougiatiotis, Georgios Paliouras. BioASQ-QA: A manually curated corpus for Biomedical Question Answering. bioRxiv 2022.12.14.520213; doi: https://doi.org/10.1101/2022.12.14.520213
- Downloads last month
- 185