instruction stringlengths 201 5.88k | input stringclasses 1
value | output stringlengths 1 3.34k |
|---|---|---|
You are a helpful medical assistant. Write down a conclusion for the following article:
Title: Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia.
Background: Chronic rhinosinusitis (CRS) is a heterogeneous disease with an uncertain pathogenesis. Group 2 inn... | As ILC2s are elevated in patients with CRSwNP, they may drive nasal polyp formation in CRS. ILC2s are also linked with high tissue and blood eosinophilia and have a potential role in the activation and survival of eosinophils during the Th2 immune response. The association of innate lymphoid cells in CRS provides insig... | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: Vagus nerve contributes to the development of steatohepatitis and obesity in phosphatidylethanolamine N-methyltransferase deficient mice.
Objective: Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enz... | Neuronal signals via the hepatic vagus nerve contribute to the development of steatohepatitis and protection against obesity in HFD fed Pemt(-/-) mice. | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts.
Background: Psammaplin A (PsA) is a natural product isolated from marine sponges, whic... | PsA significantly inhibited MCF-7/adr cells proliferation in a concentration-dependent manner, with accumulation of cells in G2/M phase of the cell cycle. PsA significantly decreased SIRT1 enzyme activity and reduced expression of SIRT1 protein in the cultured cells with greater potency than sirtinol or salermide. Acet... | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: Methylation of the FGFR2 gene is associated with high birth weight centile in humans.
Objective: This study examined links between DNA methylation and birth weight centile (BWC), and explored the impact of genetic variation. M... | We identified a novel biologically plausible candidate (FGFR2) for with BWC that merits further study. | |
You are a helpful medical assistant. Conclude the following study:
Title: Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer.
Background: Tumor microenvironment immunity is associated with breast cancer outcome. A high lymphocytic inf... | Breast cancer immune cell subpopulation profiles, determined by immunohistochemistry-based computerized analysis, identify groups of patients characterized by high response (in the pre-treatment setting) and poor prognosis (in the post-treatment setting). Further understanding of the mechanisms underlying the distribut... | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: a chart-verified case-control analysis.
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving intertrigin... | Control subjects were not validated for absence of HS and comorbidity validation was not performed for either group. | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: Reference ranges for serum and salivary testosterone in young men of Mediterranean region.
Objective: The interassay variability found in the measurement of testosterone (T) levels warrants the need for laboratories to val... | In men from the Mediterranean region, values of TT>9.7 nmol/L, CFT>0.22 nmol/L, and/or CBT>4.9 nmol/L make the presence of biochemical hypogonadism unlikely. According to the correlation between serum and ST, the clinical value of ST remains to be established. | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: Secretory phospholipases A2 are secreted from ciliated cells and increase mucin and eicosanoid secretion from goblet cells.
Background: Secretory phospholipases A2 (sPLA2) initiate the biosynthesis of eicosanoids, are increase... | sPLA2 are secreted from ciliated cells and appear to induce mucin and cysLT secretion from goblet cells, strongly suggesting that airway goblet cells are proinflammatory effector cells. | |
You are a helpful medical assistant. Write down a conclusion for the following article:
Title: Admission hyperglycemia is associated with failed reperfusion following fibrinolytic therapy in patients with STEMI: results of a retrospective study.
Background: Hyperglycemia on admission is associated with increased morta... | In patients with STEMI who undergo FT, admission hyperglycemia is an independent predictor of the failure of fibrinolysis. | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: Systematic Reviews Published in Emergency Medicine Journals Do Not Routinely Search Clinical Trials Registries: A Cross-Sectional Analysis.
Objective: Publication bias compromises the validity of systematic reviews. This ... | Systematic reviews published in emergency medicine journals do not routinely include searches of clinical trials registries. By helping authors identify unpublished trial data, the addition of registry searches may improve the validity of systematic reviews. | |
You are a helpful medical assistant. Write a conclusion for the following study:
Title: Obese patients with idiopathic pulmonary fibrosis have a higher 90-day mortality risk with bilateral lung transplantation.
Background: Obese patients with idiopathic pulmonary fibrosis (IPF) have higher 90-day mortality after lung ... | Our results suggest that obese patients who receive a BLT may be at higher risk of 90-day mortality compared with patients of normal weight. Further study is needed to obtain more detailed information about comorbidities and other risk factors for early death that are not included in the OPTN database. | |
You are a helpful medical assistant. Conclude the following study:
Title: Promoter variant rs2301228 on the neural cell adhesion molecule 1 gene confers risk of schizophrenia in Han Chinese.
Background: Schizophrenia is recognized as a disorder of the brain and neuronal connectivity. The neural cell adhesion molecule ... | Our results provide direct evidence for NCAM1 as a susceptibility gene for schizophrenia, which offers support to a neurodevelopmental model and neuronal connectivity hypothesis in the onset of schizophrenia. | |
You are a helpful medical assistant. Write a conclusion for the following study:
Title: [Higher nitric oxide levels are associated with disease activity in Egyptian rheumatoid arthritis patients].
Background: Oxidative stress generated within inflammatory joints can produce autoimmune phenomena and joint destruction. ... | There are increased levels of nitric oxide in the serum of patients with rheumatoid arthritis. Nitric oxide correlates significantly with disease activity, inflammatory markers and radiological joint status. | |
You are a helpful medical assistant. Write a conclusion for the following article:
Title: Increased Syk phosphorylation leads to overexpression of TRAF6 in peripheral B cells of patients with systemic lupus erythematosus.
Objective: Activation of B cells is a hallmark of systemic lupus erythematosus (SLE). Syk and TRA... | Our results suggest that the activated Syk-mediated TRAF6 pathway leads to aberrant activation of B cells in SLE, and also highlight Syk as a potential target for B-cell-mediated processes in SLE. | |
You are a helpful medical assistant. Write a conclusion for the following study:
Title: Reasons why erupted third molars are extracted in a public university in Mexico.
Objective: The aim of this study was to determine the reasons for which erupted third molars (3M) are extracted in a sample of Mexican patients. Metho... | Women and patients 18 to 34 years of age had erupted 3M extracted more frequently, primarily for prosthetic reasons. The age profile indicated a trend in demand for services that differ from those of overall tooth extractions, but not for the trend across gender. | |
You are a helpful medical assistant. Generate a conclusion for the following study:
Title: The Boston keratoprosthesis provides a wide depth of focus.
Objective: To measure the through-focus curve for eyes implanted with a type 1 Boston keratoprosthesis (KPro) and compare it to that of pseudophakic controls with fixed... | The KPro's wide depth-of-focus makes the visual acuity less dependent on an exact refractive correction at distance and explains the 'pseudoaccomodation' experienced by these patients. This is primarily due to the small pupil diameter of the KPro. The current manufacturing steps in 0.50 dioptre increments appears to be... | |
You are a helpful medical assistant. Generate a conclusion for the following research study:
Title: Large portion sizes increase bite size and eating rate in overweight women.
Objective: Larger food portions lead to increased intake but the mechanism behind this effect is unclear. We investigated the effect of portion... | Increasing portion size led to a larger bite size and faster eating rate, but a slower reduction in eating speed during the meal. These changes may underlie greater energy intakes with exposure to large portions. Interventions to reduce bite size and slow eating rate may provide individuals with strategies to reduce th... | |
You are a helpful medical assistant. Conclude the following study:
Title: Routine preoperative restaging CTs after neoadjuvant chemoradiation for locally advanced rectal cancer are low yield: a retrospective case study.
Background: Pre-operative restaging CT scans are often performed routinely following neoadjuvant ch... | Because of the financial costs and established risks of intravenous contrast and cumulative radiation exposure, it may be advisable to take a more selective approach to preoperative imaging. Larger, prospective studies may enable identification of an at-risk cohort who would benefit most from restaging CT. | |
You are a helpful medical assistant. Conclude the following article:
Title: Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.
Background: Plasma levels of pancreatic polypeptide (PP) rise upon food intake. Although other pancreatic islet hormones, such ... | Glucose stimulates PP secretion and PP inhibits glucagon release in mouse pancreatic islets. PP receptors are present in alpha-cells of mouse and human pancreatic islets. | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: Two decades of British newspaper coverage regarding do not attempt cardiopulmonary resuscitation decisions: Lessons for clinicians.
Objective: To review UK newspaper reports relating to Do Not Attempt Cardiopulmonary Resuscita... | Regarding DNACPR decision-making, the predominant theme was perceived lack of patient involvement, and, more recently, lack of surrogate involvement. Negative language was common, especially when decisions were presumed unilateral. Increased dialogue, and shared decision-making, is recommended. | |
You are a helpful medical assistant. Write a conclusion for the following article:
Title: Increased time from neoadjuvant chemoradiation to surgery is associated with higher pathologic complete response rates in esophageal cancer.
Background: The interval between neoadjuvant chemoradiation treatment and surgery has be... | A longer interval between completion of neoadjuvant chemoradiation and surgery was associated with higher pathologic complete response rates without an impact on surgical morbidity. | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: Epileptic focus localization based on resting state interictal MEG recordings is feasible irrespective of the presence or absence of spikes.
Objective: To investigate whether epileptogenic focus localization is possible ba... | Our preliminary results suggest that accurate localization of the epileptogenic focus may be accomplished using noninvasive spontaneous "resting-state" recordings of relatively brief duration and without the need to capture definite interictal and/or ictal abnormalities. | |
You are a helpful medical assistant. Write down a conclusion for the following article:
Title: Seminal Helicobacter pylori treatment improves sperm motility in infertile asthenozoospermic men.
Objective: To assess the effect of treatment of seminal Helicobacter pylori in infertile asthenozoospermic men. Methods: In al... | H pylori treatment significantly improves sperm motility in infertile asthenozoospermic men with elevated seminal H pylori IgA. | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids.
Background: In most cells, the cilium is formed within a compartment separated from the cytoplasm. Entry into the ciliary compar... | Our findings demonstrate that the ciliary gate can migrate away from the base of the cilium, thereby functioning independently of the centriole and of a static interaction with the axoneme to compartmentalize the site of axoneme assembly. | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: Individual Public Transportation Accessibility is Positively Associated with Self-Reported Active Commuting.
Background: Active commuters have lower risk of chronic disease. Understanding which of the, to some extent, modifiab... | This study extends the knowledge about the driving forces of using public transportation for commuting by examining the individual public transportation accessibility. Findings suggest that transportation accessibility supports active commuting and planning of improved public transit accessibility has thus a potential ... | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: Congenital penile pathology is associated with abnormal development of the dartos muscle: a prospective study of primary penile surgery at a tertiary referral center.
Objective: Pathophysiological mechanisms leading to ch... | Congenital penile pathology (hypospadias, buried penis) is associated with structural anomalies in dartos tissue. Further research is needed to unveil the pathophysiology of the condition. | |
You are a helpful medical assistant. Write a conclusion for the following article:
Title: ΔNp63 expression is a protective factor of progression in clinical high grade T1 bladder cancer.
Objective: Several risk factors have been claimed to predict the progression of clinically high grade T1 bladder tumors. However, th... | ΔNp63 expression is a favorable prognostic factor in clinically high grade T1 bladder cancer. This marker identifies patients at low risk for progression who could benefit from conservative therapy with transurethral bladder tumor resection and bacillus Calmette-Guérin, avoiding over treatment with immediate radical cy... | |
You are a helpful medical assistant. Generate a conclusion for the following study:
Title: High levels of procalcitonin in the early phase after pediatric liver transplantation indicate poor postoperative outcome.
Objective: To date, no data is available about procalcitonin (PCT) levels and its relevance to morbidity ... | High levels of PCT after pLTx are an early indicator of poor postoperative outcome and may reflect ischemia induced liver cell injury within the context of an ischemia- reperfusion injury. | |
You are a helpful medical assistant. Generate a conclusion for the following study:
Title: Decreased expression of liver-type fatty acid-binding protein is associated with poor prognosis in hepatocellular carcinoma.
Objective: The purpose of this study was to assess liver-type fatty acid-binding protein (L-FABP) expre... | L-FABP was downregulated in HCC and could be served as a promising prognostic marker for HCC patients. | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: Ephrin type-B receptor 4 activation reduces neointimal hyperplasia in human saphenous vein in vitro.
Background: Vein bypass is an essential therapy for patients with advanced peripheral and coronary artery disease despit... | Eph-B4 is present and functional in adult human saphenous veins, with intact downstream signaling pathways capable of NO release and prevention of neointimal hyperplasia in vitro. Adventitial delivery of ephrin-B2/Fc activates endothelial Eph-B4 in saphenous veins treated with arterial shear stress in vitro. These resu... | |
You are a helpful medical assistant. Generate a conclusion for the following study:
Title: Low serum levels of vitamin D are associated with post-stroke depression.
Objective: Low serum levels of vitamin D have been associated with depression in non-stroke subjects. Our aim was to examine the possible association betw... | Serum vitamin D levels within 24 h after admission are found to be associated with PSD and may predict its development at 1 month post-stroke. | |
You are a helpful medical assistant. Generate a conclusion for the following study:
Title: Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.
Objective: Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associat... | We identified 2 loci associated with risk of BE and provided data to support a further locus. The genes we found to be associated with risk for BE encode transcription factors involved in thoracic, diaphragmatic, and esophageal development or proteins involved in the inflammatory response. | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase.
Background: Danzhi Xiaoyao San (DXS) is a canonical Chinese medicine ... | DXS exhibited antidepressant-like effects on rats exposed to CUMS. DXS reduced IDO activity to shift the balance of the Kyn/5-HT pathway toward the 5-HT pathway. | |
You are a helpful medical assistant. Write a conclusion for the following article:
Title: p63 is more sensitive and specific than 34βE12 to differentiate adenocarcinoma of prostate from cancer mimickers.
Objective: Prostate cancer is the world's leading cause of cancer and the second cause of cancer-related death in m... | Basal cell markers can help to distinguish prostate adenocarcinoma from cancer mimickers. | |
You are a helpful medical assistant. Conclude the following article:
Title: Poor sleep predicts symptoms of depression and disability retirement due to depression.
Background: Disturbed sleep is associated with mood disorders. Both depression and insomnia may increase the risk of disability retirement. The longitudina... | Lack of baseline diagnostic interviews; sleep quality based on self-report. | |
You are a helpful medical assistant. Conclude the following study:
Title: Phospholipase C epsilon 1 (PLCE1) haplotypes are associated with increased risk of gastric cancer in Kashmir Valley.
Objective: Phospholipase C epsilon 1 (PLCE1) plays a crucial role in carcinogenesis and progression of several types of cancers.... | These results suggest that variation in PLCE1 may be associated with GC risk in Kashmir Valley. | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: TGFBI Expression in Cancer Stromal Cells is Associated with Poor Prognosis and Hematogenous Recurrence in Esophageal Squamous Cell Carcinoma.
Background: Esophageal squamous cell carcinoma (ESCC) is an important cause of c... | High TGFBI expression in ESCC tissues could be a powerful biomarker of poor prognosis and hematogenous recurrence. TGFBI in stromal cells might be a promising molecular target for ESCC treatment. | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: Autoimmune features are associated with chronic antibiotic-refractory pouchitis.
Background: Chronic antibiotic-refractory pouchitis (CARP) occurs more frequently in patients with ileal pouch-anal anastomosis (IPAA) with ... | There is marked overlap of certain immune markers in patients with pouch dysfunction, especially those with CARP. Microsomal antibody expression and elevated IgG4-positive plasma cell infiltration were independent risk factors for CARP. | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: Identical ATP1A3 mutation causes alternating hemiplegia of childhood and rapid-onset dystonia parkinsonism phenotypes.
Background: Alternating hemiplegia of childhood and rapid-onset dystonia parkinsonism are two separate... | The discordance of these phenotypes suggests that there are other undiscovered environmental, genetic, or epigenetic factors influencing the development of alternating hemiplegia of childhood or rapid-onset dystonia parkinsonism. | |
You are a helpful medical assistant. Write a conclusion for the following medical study:
Title: Metabolic control analysis of the Trypanosoma cruzi peroxide detoxification pathway identifies tryparedoxin as a suitable drug target.
Background: The principal oxidative-stress defense in the human parasite Trypanosoma cru... | These quantitative kinetic and metabolic analyses pointed out to TXN as a convenient drug target due to its low catalytic efficiency, high control on the flux of peroxide detoxification and role as provider of reducing equivalents to the two main peroxidases in the parasite. | |
You are a helpful medical assistant. Conclude the following article:
Title: Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis.
Background: The role of Kdr (VEGFR-2/Flk-1) in vascular formation has been well described, but the role of ... | Flt1-tyrosine kinase (TK) activity contributed significantly in endothelial cells survival and vascular development during embryo angiogenesis in zebrafish by engaging PI3K/Akt pathway. | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: Immunizations with hepatitis B viral antigens and a TLR7/8 agonist adjuvant induce antigen-specific immune responses in HBV-transgenic mice.
Background: The capacity of toll-like receptor (TLR) 7/8 agonist-conjugated hepatitis... | Immunization with CL097-conjugated HBV-Ag reversed immune tolerance in HBV-Tg mice and induced antigen-specific immune responses. TLR7/8 agonists appear to be potent adjuvants for the induction of antigen-specific Th1 responses in an immune tolerant state. | |
You are a helpful medical assistant. Write a conclusion for the following medical study:
Title: Lobar microbleeds are associated with a decline in executive functioning in older adults.
Background: Normal aging is associated with a decline in cognitive abilities, particularly in the domains of psychomotor speed and ex... | Lobar microbleeds, a marker of cerebral amyloid angiopathy, are associated with an accelerated rate of executive function decline. The presence of cerebral amyloid angiopathy may be an important source of cognitive decline in aging. Future work should examine how cerebral amyloid angiopathy interacts with neurodegenera... | |
You are a helpful medical assistant. Generate a conclusion for the following research study:
Title: cannot get document summary
Background: In recent years, the relationship between physical activity (PA) and smoking cessation has been increasingly studied. However, very few studies have investigated the possible prot... | Previous quit attempts and professional activity were positive predictors of smoking abstinence, with alcohol use disorder a negative predictor. PA was not found to be a significant predictor of smoking relapse, with only a positive interaction term seen for persons on antidepressant treatment. (Am J Addict 2014;XX:1-7... | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: Breathlessness at rest is not the dominant presentation of patients admitted with heart failure.
Objective: Many assume that most patients hospitalized with heart failure (HF) are short of breath at rest (SOBAR). The Natio... | Many patients admitted with HF are CARBOSE. Shortness of breath at rest may be more alarming, but those who are CARBOSE have a worse prognosis, perhaps reflecting more severe right heart dysfunction. Clinical trials of hospitalized HF may inappropriately exclude patients if they focus on shortness of breath at rest rat... | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: Delayed duodenal stump blow-out following total gastrectomy for cancer: Heightened awareness for the continued presence of the surgical past in the present is the key to a successful duodenal stump disruption management. A... | Several strategies have been proposed for the successful management post-gastrectomy duodenal stump disruption however; its treatment planning is absolutely determined by the presence or not of generalized peritonitis and hemodynamic instability with hostile abdomen. In such scenario, urgent reoperation is mandatory an... | |
You are a helpful medical assistant. Write down a conclusion for the following article:
Title: Lipoprotein phospholipase A2 mass and activity are not associated with the diagnosis of acute brain ischemia.
Background: Elevated lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with both coronary ar... | The results of our study do not support the early measurement of Lp-PLA2 mass or activity levels for confirming an ischemic etiology in patients experiencing minor or transient focal neurological events. | |
You are a helpful medical assistant. Write down a conclusion for the following article:
Title: Osteoprotegerin is associated with subclinical left ventricular systolic dysfunction in diabetic hypertensive patients: a speckle tracking study.
Background: Recently, the role of osteoprotegerin (OPG) in the pathogenesis of... | Plasma OPG values could predict subclinical LV systolic dysfunction in diabetic hypertensive patients. | |
You are a helpful medical assistant. Generate a conclusion for the following study:
Title: A new model for the standardization of experimental burn wounds.
Background: Burns are common and recurrent events treated by physicians on a daily basis at most emergency rooms around the world. There is a constant need to unde... | This is a safe, reliable, easy to construct and use model that has the ability to produce a regular and uniform reproducible burn due to precise temperature control associated with standardized animal positioning. | |
You are a helpful medical assistant. Generate a conclusion for the following research study:
Title: Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with stroke in whites.
Background: The goal of this study was to identify genetic determinants of plasma N-term... | This is the first large-scale genetic association study of circulating NT-proANP levels performed with replication and functional assessment that identified genetic variants in the MTHFR-CLCN6-NPPA-NPPB cluster to be significantly associated with NT-proANP levels. The clinical significance of this variation is related ... | |
You are a helpful medical assistant. Write a conclusion for the following article:
Title: Whole-genome sequencing and epidemiological analysis do not provide evidence for cross-transmission of mycobacterium abscessus in a cohort of pediatric cystic fibrosis patients.
Background: Mycobacterium abscessus has emerged as ... | We have not demonstrated cross-transmission of M. abscessus within our hospital, except between 1 sibling pair. Alternative routes of acquisition of M. abscessus infection, in particular the environment, require further investigation. | |
You are a helpful medical assistant. Conclude the following study:
Title: High Atopobium vaginae and Gardnerella vaginalis vaginal loads are associated with preterm birth.
Background: Bacterial vaginosis is a risk factor for preterm birth. The various conventional methods for its diagnosis are laborious and not easily... | High vaginal loads of A. vaginae and G. vaginalis are associated with late miscarriage and prematurity in high-risk pregnancies. A high vaginal load of A. vaginae (DNA level ≥10(8) copies/mL) identifies a population at high risk of preterm birth. Further studies that both screen for and then treat A. vaginae are needed... | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: CD30 expression is a novel prognostic indicator in extranodal natural killer/T-cell lymphoma, nasal type.
Background: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL), is an aggressive type of lymphoma whose ... | Our results showed that expression of CD30 was not related to response to treatment but was an independent prognostic factor for both OS and PFS in ENKTL, nasal type, which suggests a role for CD30 in the pathogenesis of this disease and may support the incorporation of anti-CD30-targeted therapy into the treatment par... | |
You are a helpful medical assistant. Write a conclusion for the following study:
Title: [Clinical study on continuous plasma filtration absorption treatment for burn sepsis].
Objective: To observe the therapeutic effects of continuous plasma filtration absorption (CPFA) treatment on burn sepsis. Methods: Thirty burn p... | CPFA, which combines hemoabsorption and hemofiltration, can facilitate the treatment of burn sepsis by decreasing the level of pro-inflammatory cytokines efficiently, alleviating systemic inflammatory response, and improving the immune status. | |
You are a helpful medical assistant. Write a conclusion for the following medical study:
Title: [Perinatal variables from newborns of Aymara mothers suggest a genetic adaptation to high altitude].
Background: Studies performed in Andean populations living in high altitude, indicate that the reduced availability of oxy... | Altitude of residence is related to a decrease in perinatal variables that proved to be less pronounced in newborns of mothers with a higher degree of Aymara ancestry. RESULTS suggest a genetic adaptation to hypoxia that could be related to candidate genes linked to the capture, transport or utilization of oxygen. | |
You are a helpful medical assistant. Write a conclusion for the following medical study:
Title: 25-hydroxyvitamin D status is associated with chronic cerebral small vessel disease.
Objective: The aim of this study was to determine the association between 25-hydroxyvitamin D (25(OH)D) and neuroimaging correlates of cer... | 25(OH)D is inversely associated with lacunes, white matter hyperintensity, and deep CMB. Our findings suggest that 25(OH)D is linked to small vessel disease, and in future trials it should be tested whether 25(OH)D supplementation can prevent small vessel disease. | |
You are a helpful medical assistant. Conclude the following article:
Title: CD133-positive tumor cell content is a predictor of early recurrence in colorectal cancer.
Background: The aims of this study were to demonstrate the tumorigenicity of CD133+ colon cancer cells in vitro, analyze the correlations between sphero... | These findings indicate that CD133 is a valid marker for identifying cancer stem cells from fresh surgically resected colorectal cancer tissues. Furthermore, we successfully established a living tumor tissue bank using surgically resected colorectal tissues with a viability of >70%. | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: Traumatic brain injury induces neuroinflammation and neuronal degeneration that is associated with escalated alcohol self-administration in rats.
Background: Traumatic brain injury (TBI) affects millions of people each yea... | These results show an association between post-TBI escalation of alcohol drinking and marked localized neuroinflammation at the site of injury. Moreover, these results highlight the relevance of baseline alcohol preference in determining post-TBI alcohol drinking. Further investigation to determine the contribution of ... | |
You are a helpful medical assistant. Generate a conclusion for the following study:
Title: Maternal undernutrition induces premature reproductive senescence in adult female rat offspring.
Objective: To determine the effects of maternal undernutrition (MUN) on the reproductive axis of aging offspring. Methods: Animal (... | Our data indicate that the maternal nutritional environment programs the reproductive potential of the offspring through alteration of the hypothalamic-pituitary-gonadal axis. The premature reproductive senescence in LBW offspring could be secondary to the development of obesity and hyperleptinemia in these animals in ... | |
You are a helpful medical assistant. Conclude the following study:
Title: Granulocyte colony-stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy.
Objective: To determine whether granulocyte colony-stimulating factor (G-CSF) could prevent loss of spermatogenesis induced by busulf... | These results demonstrate that G-CSF protects spermatogenesis from gonadotoxic insult (busulfan) in rodents, and this may occur via direct action on CSF3R+ undifferentiated spermatogonia. G-CSF treatment might be an effective adjuvant therapy to preserve male fertility in cancer patients receiving sterilizing treatment... | |
You are a helpful medical assistant. Write a conclusion for the following article:
Title: Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.
Objective: A vaccine against hepatitis C virus (HCV) is unavailable and cost-effective antivirals that prevent HCV infection an... | Due to its potency, SSb2 may be of value for development as an antagonist of HCV entry and could be explored as prophylactic treatment during the course of liver transplantation. | |
You are a helpful medical assistant. Write a conclusion for the following article:
Title: Autotaxin activity has a high accuracy to diagnose intrahepatic cholestasis of pregnancy.
Objective: Intrahepatic cholestasis of pregnancy (ICP) is defined by pruritus, elevated total fasting serum bile salts (TBS) and transamina... | Increased serum autotaxin activity represents a highly sensitive, specific and robust diagnostic marker of ICP, distinguishing ICP from other pruritic disorders of pregnancy and pregnancy-related liver diseases. Pregnancy and oral contraception increase serum autotaxin to a much lesser extent than ICP. | |
You are a helpful medical assistant. Conclude the following study:
Title: A dedicated research program increases the quantity and quality of orthopaedic resident publications.
Background: Programs seek to expose trainees to research during residency. However, little is known in any formal sense regarding how to do thi... | Currently in the United States, there are no standard policies or requirements that dictate how research should be incorporated in orthopaedic surgery residency training programs. The results of our study suggest that implementation of a dedicated resident research program improves the quantity and to some extent quali... | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: Cationic Nanogel-mediated Runx2 and Osterix siRNA Delivery Decreases Mineralization in MC3T3 Cells.
Background: Heterotopic ossification (HO) may occur after musculoskeletal trauma, traumatic brain injury, and total joint ... | Although mRNA and protein knockdown were confirmed as a result of RNAi treatments against Runx2 and Osx, complete elimination of mineralization processes was not achieved. RNAi targeting mid- and late-stage osteoblast differentiation markers such as ALP, osteocalcin, osteopontin, and bone sialoprotein) may produce the ... | |
You are a helpful medical assistant. Conclude the following article:
Title: No sex differences exist in posterior condylar offsets of the knee.
Background: Restoration of posterior condylar offset during TKA is believed to be important to improving knee kinematics, maximizing ROM, and minimizing flexion instability. H... | Results of our study showed that knees in males exhibited greater posterior condylar offset and greater total condylar height at the medial and lateral femoral condyles, however, there were no sex differences in the ratio of posterior condylar offset to condylar height at either condyle. | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: Gene polymorphisms of stress hormone and cytokine receptors associate with immunomodulatory profile and psychological measurement.
Objective: We sought to identify whether stable single nucleotide polymorphisms (SNPs) of v... | The data support the notion that gene polymorphisms from various components of the psychoneuroendocrine-immune network may be useful as biomarkers to categorize individual stress-associated immune responses. | |
You are a helpful medical assistant. Generate a conclusion for the following research study:
Title: Housing temperature influences the pattern of heat shock protein induction in mice following mild whole body hyperthermia.
Objective: Researchers studying the murine response to stress generally use mice housed under st... | Taken together, these data show that housing temperature significantly influences the expression of HSPs in mice after whole body heating and thus should be considered when stress responses are studied in mice. | |
You are a helpful medical assistant. Write a conclusion for the following medical study:
Title: Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model.
Background: The important functions of the meniscus are shock absorption, passive stabilizatio... | An intra-articular injection of ds miR-210 was effective in the healing of the damaged white zone meniscus through promotion of the collagen type 2 production from meniscus cells and through upregulated of VEGF and FGF2 from synovial cells. | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: PRMT5 enhances generation of induced pluripotent stem cells from dairy goat embryonic fibroblasts via down-regulation of p53.
Objective: Protein arginine methyltransferase 5 (PRMT5), is thought to play a role in epigeneti... | This study provides an efficient model for future studies on mechanisms underlying goat somatic cell reprogramming and differentiation. | |
You are a helpful medical assistant. Write a conclusion for the following study:
Title: Minimally invasive retroperitoneoscopic surgery for psoas abscess with thoracolumbar tuberculosis.
Objective: Minimally invasive retroperitoneoscopic surgery (MIS) for psoas abscess (PA) in patients with thoracolumbar tuberculosis ... | The retroperitoneoscopic technique for PA gain advantages in terms of shorter hospital stay, minimal invasiveness, absence of radiation, quicker recovery to daily life compared with percutaneous drainage, and anterior or posterior debridement surgery. Despite the technique not been fully clinically proved, it seems to ... | |
You are a helpful medical assistant. Conclude the following article:
Title: Cartilage thickness at the posterior medial femoral condyle is increased in femorotibial knee osteoarthritis: a cross-sectional CT arthrography study (Part 2).
Objective: To evaluate the thickness of cartilage at the posterior aspect of the me... | Cartilage thickness at the non-weight-bearing posterior aspect of the medial condyle, but not of the lateral condyle, was increased in OA knees compared to non-OA knees. Furthermore, cartilage thickness at the posterior aspect of the medial condyle increased with increasing K/L grade. | |
You are a helpful medical assistant. Write a conclusion for the following article:
Title: Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis.
Objective: To investigate the specific role of Frizzled-related protein (FRZB) and Secreted frizzled-related protein 1 (SFRP1)... | Using the DMM model, we demonstrated that FRZB and SFRP1 differentially modulate joint homeostasis in two distinct compartments of the joint. These data highlight the fine-tuning of Wnt signaling in joint homeostasis and disease, show differential regulation of the cascade in cartilage and subchondral bone, and provide... | |
You are a helpful medical assistant. Write a conclusion for the following medical study:
Title: Tetraploid complementation proves pluripotency of induced pluripotent stem cells derived from adipose tissue.
Objective: Recently, pluripotency of induced pluripotent stem (iPS) cells has been displayed after producing adul... | We also directed differentiation of iPS cells into chondrocytes, thus adipose-derived iPS cells can be used as models to study chondrogenic differentiation and cartilage regeneration. | |
You are a helpful medical assistant. Write a conclusion for the following study:
Title: Implementation of the acute care surgery model provides benefits in the surgical treatment of the acute appendicitis.
Background: Several reports have indicated the benefits of the acute care surgery (ACS) model in surgical outcome... | The ACS model may improve abdominal surgical efficiency and quality. Our study results echoed the benefits of the implementation of the ACS model shown in North America. | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: Radiofrequency ablation plus devascularization is the preferred treatment of hepatocellular carcinoma with esophageal varices.
Background: Most hepatocellular carcinomas (HCCs) are associated with cirrhosis. Portal hypertensio... | RFA plus devascularization is the preferred treatment of HCC with EVB. RFA plus devascularization should be considered in Child-Pugh class A patients below 50 years of age. | |
You are a helpful medical assistant. Write a conclusion for the following medical study:
Title: Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy.
Objective: Assessment of the activity of thioridazine towards Mycobacterium tuber... | Thioridazine is bactericidal towards Mtb in vitro, irrespective the mycobacterial growth rate and results in enhanced activity of the standard regimen. The in vitro activity of thioridazine in potentiating isoniazid and rifampicin is not reflected by improved therapeutic efficacy in a murine TB-model. | |
You are a helpful medical assistant. Write a conclusion for the following study:
Title: Youth walking and biking rates vary by environments around 5 Louisiana schools.
Background: The prevalence of obesity in children is high, and many do not meet physical activity recommendations. The Safe Routes to School (SRTS) pro... | There is a role and a need for the SRTS program. The environment and other factors influence biking and walking to school. | |
You are a helpful medical assistant. Conclude the following study:
Title: Blockade of Central Angiotensin II AT1 Receptor Protects the Brain from Ischemia/Reperfusion Injury in Normotensive Rats.
Background: Stroke is the third leading cause of invalidism and death in industrialized countries. There are conflicting re... | Angiotensin II by stimulating AT1 receptors, participates in ischemia-reperfusion injuries and edema formation. AT1 receptor blockade with candesartan decreased ischemic brain injury and edema and improved neurological outcome. | |
You are a helpful medical assistant. Generate a conclusion for the following study:
Title: Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly.
Background: Genetic haploinsufficiency of SYNGAP1/Syngap1 commonly occurs in development... | Pathogenic Syngap1 mutations have a profound impact on the dynamics and structural integrity of pyramidal cell postsynaptic structures known to guide the de novo wiring of nascent cortical circuits. These findings support the idea that disrupted critical periods of dendritic growth and spine plasticity may be a common ... | |
You are a helpful medical assistant. Write a conclusion for the following article:
Title: Pentraxin 3 is reduced in bipolar disorder.
Objective: Immunologic abnormalities have been found in bipolar disorder but pentraxin 3, a marker of innate immunity, has not been studied in this population. Methods: Levels of pentra... | Individuals with bipolar disorder have low levels of pentraxin 3 which may reflect impaired innate immunity. An increased understanding of the role of innate immunity in the etiopathogenesis of bipolar disorder might lead to new modalities for the diagnosis and treatment of this disorder. | |
You are a helpful medical assistant. Conclude the following article:
Title: Human enteroviruses are not the cause of neurological impairments in children at the Korle-Bu Teaching Hospital.
Background: Convulsions associated with fever and acute onset of unknown aetiology with case fatalities have become a long observe... | Non-polio enteroviruses and chikugunya virus were found not to be the etiologic agent responsible for the convulsion with neurologic morbidity observed in the Ghanaian children. Investigation for other viral agents is recommended. | |
You are a helpful medical assistant. Conclude the following article:
Title: A whole blood-based perfusate provides superior preservation of myocardial function during ex vivo heart perfusion.
Background: Ex vivo heart perfusion (EVHP) provides the opportunity to resuscitate unused donor organs and facilitates assessme... | A whole blood-based perfusate (RBC+Plasma) minimizes injury and provides superior preservation of myocardial function during EVHP. The beneficial effect of plasma on the preservation of myocardial function requires further investigation. | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: Elevated immune monitoring early after cardiac transplantation is associated with increased plaque progression by intravascular ultrasound.
Background: Immune monitoring (IM) has not been shown to be associated with cardiac al... | Elevated early IM scores are associated with progression of CAV by IVUS. These findings suggest the potential of IM for tailoring of immunosuppressive regimens to minimize the progression of CAV in high-risk patients. | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: Successional changes in the chicken cecal microbiome during 42 days of growth are independent of organic acid feed additives.
Background: Poultry remains a major source of foodborne bacterial infections. A variety of addi... | Over the 42 d experiment, the cecal bacterial community changed significantly as measured by a variety of ecological metrics and increases in the complexity of co-occurrence networks. Management of poultry to improve animal health, nutrition, or food safety may need to consider the interactive effects of any treatments... | |
You are a helpful medical assistant. Conclude the following article:
Title: Resveratrol enhances palmitate-induced ER stress and apoptosis in cancer cells.
Background: Palmitate, a saturated fatty acid (FA), is known to induce toxicity and cell death in various types of cells. Resveratrol (RSV) is able to prevent path... | Our results suggest that RSV exerts its cytotoxic role in cancer cells exposed to a saturated FA context primarily by triglyceride accumulation inhibition, probably leading to an intracellular palmitate accumulation that triggers a lipid-mediated cell death. Additionally, this cell death is promoted by ER stress throug... | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: CDK1 and CDK2 activity is a strong predictor of renal cell carcinoma recurrence.
Background: In renal cell carcinoma (RCC), the prediction of metastasis via tumor prognostic markers remains a major problem. The objective o... | CDK1SA of tumors and the CDK2SA are both associated with recurrence and prognosis. | |
You are a helpful medical assistant. Generate a conclusion for the following study:
Title: Torsion of the optic nerve head is a prominent feature of normal-tension glaucoma.
Objective: To compare optic nerve head (ONH) morphology between eyes with normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG). M... | Normal-tension glaucoma eyes had a greater ONH torsion compared to POAG eyes with matched axial length. The direction of the ONH tilt and torsion was related to the location of the visual field defect only in NTG eyes. | |
You are a helpful medical assistant. Generate a conclusion for the following research study:
Title: Endo first is not appropriate in some patients with critical limb ischemia because "bridges are burned".
Background: The aims of this study were to determine the effect of failed prior endovascular treatment (EV) on ear... | Previous failed EV should be predictive of poor outcome in patients undergoing distal OS for CLI. | |
You are a helpful medical assistant. Write a conclusion for the following research study:
Title: Unrecognized arteriosclerosis is associated with wound complications after below-knee amputation.
Background: Guillotine below-knee amputation (BKA) for wet gangrene is an unfortunate complication of poorly controlled diab... | After formalization of lower extremity amputation for wet gangrene, traditional markers of PAD were not predictive of wound complications. Although formalization of guillotine BKA can safely be performed without significant delay, more thorough assessment of microvascular disease in the perioperative period may be usef... | |
You are a helpful medical assistant. Write a conclusion for the following study:
Title: Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats.
Background: Remote renal ischemia-reperfusion injury (IRI) following infra-renal aortic occlusion leads to acute kidney injury and systemic inflamm... | Hydrogen sulfide has systemic and renal anti-inflammatory effects in remote IRI following aortic occlusion in rats. | |
You are a helpful medical assistant. Write a conclusion for the following article:
Title: Seed bank dynamics govern persistence of Brassica hybrids in crop and natural habitats.
Objective: Gene flow from crops to their wild relatives has the potential to alter population growth rates and demography of hybrid populatio... | Hybrid persistence was found to be highly dependent on the seed bank, suggesting that targeting hybrid seed survival could be an important management option in controlling hybrid persistence. For local risk mitigation, an increased focus on the wild parent is suggested. Management actions, such as control of B. rapa, c... | |
You are a helpful medical assistant. Write down a conclusion for the following article:
Title: Actinic keratosis with atypical basal cells (AK I) is the most common lesion associated with invasive squamous cell carcinoma of the skin.
Background: Progression from actinic keratosis (AK) to invasive squamous cell carcino... | Direct invasion from proliferating basaloid atypical keratinocytes limited to the epidermal basal layer (AK I), known as the differentiated pathway, was the most common form of progression to cutaneous iSCC in our series. On the other hand, stepwise progression from AK I to AK II and AK III (classic pathway) was seen t... | |
You are a helpful medical assistant. Conclude the following study:
Title: High-intensity intermittent exercise increases pulmonary interstitial edema at altitude but not at simulated altitude.
Objective: Ascent to high altitude leads to a reduction in ambient pressure and a subsequent fall in available oxygen. The res... | HIIE led to an increase in B-lines at altitude after subacute exposure but not during acute exposure at equivalent simulated altitude. This may indicate pulmonary interstitial edema. | |
You are a helpful medical assistant. Generate a conclusion for the following study:
Title: Mild cognitive dysfunction does not affect diabetes mellitus control in minority elderly adults.
Objective: To determine whether older adults with type 2 diabetes mellitus and cognitive dysfunction have poorer metabolic control ... | Cognitive dysfunction in the mild range did not seem to affect diabetes mellitus control parameters in this multiethnic cohort of older adults with diabetes mellitus, although it cannot be excluded that cognitive impairment was overcome through assistance from formal or informal caregivers. It is possible that more-sev... | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: Anti-high mobility group box 1 (anti-HMGB1) antibodies are not related to the occurrence of cutaneous lesions in systemic lupus erythematosus.
Objective: To investigate whether serum anti-high mobility group box 1 (anti-H... | Based on the findings of the current study, it is unlikely that anti-HMGB1 antibodies play a role in the development of SLE cutaneous lesions. | |
You are a helpful medical assistant. Write a conclusion for the following study:
Title: Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.
Objective: Excessive consumption of ethanol is one of the most common causes of acute and chron... | Based on studies of human, mouse, and guinea pig pancreata, alcohol disrupts expression and localization of the CFTR. This appears to contribute to development of pancreatitis. Strategies to increase CFTR levels or function might be used to treat alcohol-associated pancreatitis. | |
You are a helpful medical assistant. Conclude the following study:
Title: Blood viscosity but not shear stress associates with delayed flow-mediated dilation.
Objective: Flow-mediated dilation (FMD) is a complex mechanism involving several mediators, and different hemodynamic forces. Temporally distinct FMD patterns c... | The present study demonstrates that age and blood viscosity but not the magnitude of SS explain the different timing of the dilatory response to ischemia. | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: Hypercholesterolemia increases the production of leukotriene B4 in neutrophils by enhancing the nuclear localization of 5-lipoxygenase.
Objective: Neutrophils can synthesize leukotriene B4 (LTB4) by activating the 5-lipoxygena... | Hypercholesterolemia increases LTB4 production in neutrophils by increasing the nuclear localization of 5-LO, which is the result of its phosphorylation by activated ERK1/2. | |
You are a helpful medical assistant. Write a conclusion for the following medical article:
Title: Molecular signatures of mood stabilisers highlight the role of the transcription factor REST/NRSF.
Background: The purpose of this study was to address the affects of mood modifying drugs on the transcriptome, in a tissue... | Cell line models offer a window of what might happen in vivo but have the benefit of being human derived and homogenous with regard to cell type. | |
You are a helpful medical assistant. Generate a conclusion for the following article:
Title: Preconditioning of skeletal myoblast-based engineered tissue constructs enables functional coupling to myocardium in vivo.
Objective: Skeletal myoblasts fuse to form functional syncytial myotubes as an integral part of the ske... | Although untreated skeletal myoblasts cannot couple to cardiomyocytes, we confirm that mechanical preconditioning enables transplanted skeletal myoblasts to functionally interact with cardiomyocytes in vivo and, thus, reinvigorate the concept of skeletal myoblast-based cardiac cell therapy. |
End of preview. Expand in Data Studio
No dataset card yet
- Downloads last month
- 9