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Theophylline intoxication mimicking diabetic ketoacidosis in a child.	[ { "ade": "Theophylline intoxication", "drug": "Theophylline" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Theophylline intoxication mimicking diabetic ketoacidosis in a child.", "role": "user" }, { "content": "Drug: Theophylline, ADE: Theophylline intoxication", "role": "assistant" } ]
The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.	[ { "ade": "respiratory failure", "drug": "gold" }, { "ade": "pulmonary toxicity", "drug": "gold" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.", "role": "user" }, { "content": "Drug: gold, ADE: respiratory failure; Drug: gold, ADE: pulmonary ...
In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.	[ { "ade": "pulmonary toxicity", "drug": "gemcitabine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.", "role": "user" }, { "content": "Drug: gemcitabine, ADE: pulmonar...
Methotrexate induced sprue-like syndrome.	[ { "ade": "sprue-like syndrome", "drug": "Methotrexate" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Methotrexate induced sprue-like syndrome.", "role": "user" }, { "content": "Drug: Methotrexate, ADE: sprue-like syndrome", "role": "assistant" } ]
Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature.	[ { "ade": "pancreatitis", "drug": "amiodarone" }, { "ade": "Pancreatitis", "drug": "amiodarone" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature.", "role": "user" }, { "cont...
In this paper, we report a patient with primary anti-phospholipid syndrome treated by corticosteroid, who developed disseminated nocardiosis.	[ { "ade": "disseminated nocardiosis", "drug": "corticosteroid" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: In this paper, we report a patient with primary anti-phospholipid syndrome treated by corticosteroid, who developed disseminated nocardiosis.", "role": "user" }, { "content": "Drug: corticosteroid, ...
CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy.	[ { "ade": "visual field constriction", "drug": "vigabatrin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy.", "role": "user" }, { "content": "Drug: vigabatrin, ADE: visual field constriction", "role": "assis...
The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.	[ { "ade": "migraine headaches", "drug": "methysergide" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.", "role": "user" }, { "content": "Drug: methysergide, ADE: migraine headaches", "role": ...
A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.	[ { "ade": "moderately severe bronchospasm", "drug": "disodium cromoglycate" }, { "ade": "urticarial rash", "drug": "disodium cromoglycate" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.", "role": "user" }, { "content": "Drug: disod...
OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review.	[ { "ade": "priapism", "drug": "zuclopenthixol" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review.", "role": "user" }, { "content": "Drug: zuclopenthixol, ADE: priapism", "role": "assistant" } ]
Refractory hypoglycemia from ciprofloxacin and glyburide interaction.	[ { "ade": "Refractory hypoglycemia", "drug": "ciprofloxacin" }, { "ade": "Refractory hypoglycemia", "drug": "glyburide" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Refractory hypoglycemia from ciprofloxacin and glyburide interaction.", "role": "user" }, { "content": "Drug: ciprofloxacin, ADE: Refractory hypoglycemia; Drug: glyburide, ADE: Refractory hypoglycem...
CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia.	[ { "ade": "leukopenia", "drug": "Cefazolin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia.", "role": "user" }, { "content": "Drug: Cefazolin, ADE: leukopenia", "role": "assistant" } ]
We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.	[ { "ade": "fulminant hepatic failure", "drug": "flucloxacillin" }, { "ade": "aplastic anaemia", "drug": "flucloxacillin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.", "role": "user" }, { "content": "Drug: flucloxacill...
CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.	[ { "ade": "increase of INR", "drug": "levamisole" }, { "ade": "increase of INR", "drug": "5-FU" }, { "ade": "increase of INR", "drug": "warfarin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.", "role"...
An objective causality assessment suggests that the JHR in our patient was probably related to penicillin.	[ { "ade": "JHR", "drug": "penicillin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: An objective causality assessment suggests that the JHR in our patient was probably related to penicillin.", "role": "user" }, { "content": "Drug: penicillin, ADE: JHR", "role": "assistant" } ...
Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.	[ { "ade": "lymphoproliferative disorders", "drug": "MM" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.", "role": "user" }, { "content"...
After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication.	[ { "ade": "gastric-outlet obstruction", "drug": "prostaglandin E1" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication.", "role": "user" }, { "content": ...
A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (1970 to 1973) with human growth hormone processed from pooled cadaveric pituitary glands.	[ { "ade": "Creutzfeldt-Jakob disease", "drug": "human growth hormone" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (19...
The occurrence of acute hepatitis is best known for ketoconazole.	[ { "ade": "hepatitis", "drug": "ketoconazole" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: The occurrence of acute hepatitis is best known for ketoconazole.", "role": "user" }, { "content": "Drug: ketoconazole, ADE: hepatitis", "role": "assistant" } ]
INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.	[ { "ade": "interstitial lung disease", "drug": "gefitinib" }, { "ade": "ILD", "drug": "erlotinib" }, { "ade": "ILD", "drug": "gefitinib" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.", ...
We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.	[ { "ade": "colonic ulcer", "drug": "calcium polystyrene sulfonate" }, { "ade": "sigmoidovesical fistula", "drug": "calcium polystyrene sulfonate" }, { "ade": "sigmoidovesical fistula", "drug": "sorbitol" }, { "ade": "colonic ulcer", "drug": "sorbitol" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.", "role": "user" }, { "content": "Drug: calci...
Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine.	[ { "ade": "tardive OGC", "drug": "clozapine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine.", "role": "user" }, { "content": "Drug: clozapine, ADE: tardive OGC", "role": "assistant" } ]
Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.	[ { "ade": "neurotoxicity", "drug": "methotrexate" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.", "role": "us...
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.	[ { "ade": "Intrahepatic cholestasis", "drug": "glibenclamide" }, { "ade": "cutaneous bullae", "drug": "glibenclamide" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.", "role": "user" }, { "conte...
Methylphenidate-associated enuresis in attention deficit hyperactivity disorder.	[ { "ade": "enuresis", "drug": "Methylphenidate" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Methylphenidate-associated enuresis in attention deficit hyperactivity disorder.", "role": "user" }, { "content": "Drug: Methylphenidate, ADE: enuresis", "role": "assistant" } ]
We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts.	[ { "ade": "necrotizing pancreatitis", "drug": "L-asparaginase" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts.", "role...
Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.	[ { "ade": "altered mental status", "drug": "valproic acid" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.", "role": "user" }...
We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.	[ { "ade": "hepatitis", "drug": "IFN beta" }, { "ade": "liver injury", "drug": "IFN beta" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.", "role": "user" }, { "content": "Drug: IFN beta, A...
Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.	[ { "ade": "fever", "drug": "Amphotericin B" }, { "ade": "malaise", "drug": "AmB" }, { "ade": "anaemia", "drug": "Amphotericin B" }, { "ade": "anaemia", "drug": "AmB" }, { "ade": "malaise", "drug": "Amphotericin B" }, { "ade": "renal impairment", "dr...	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.", "role": "user" }, { "content": "Drug: Amphotericin B,...
Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.	[ { "ade": "severe neutropenia", "drug": "olanzapine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.", "role": "user" }, { "content": "Drug: olanzapine, ADE: severe neutropenia", "role": "...
Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.	[ { "ade": "acute vision loss", "drug": "bevacizumab" }, { "ade": "change of consciousness", "drug": "bevacizumab" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.", "role": "user" }, { "content": "Drug: bevacizumab,...
CONTEXT: Previous investigators have reported discrepancies between hematologic, marrow morphologic, and cytogenetic responses to imatinib mesylate among patients with chronic myeloid leukemia (CML).	[ { "ade": "discrepancies between hematologic, marrow morphologic, and cytogenetic responses", "drug": "imatinib mesylate" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONTEXT: Previous investigators have reported discrepancies between hematologic, marrow morphologic, and cytogenetic responses to imatinib mesylate among patients with chronic myeloid leukemia (CML).", "rol...
Bleomycin induced hyperpigmentation with yolk sac tumor.	[ { "ade": "hyperpigmentation", "drug": "Bleomycin" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Bleomycin induced hyperpigmentation with yolk sac tumor.", "role": "user" }, { "content": "Drug: Bleomycin, ADE: hyperpigmentation", "role": "assistant" } ]
DISCUSSION: Methotrexate-induced papular eruption is rarely reported shortly after beginning methotrexate therapy in patients with acute exacerbation of collagen vascular diseases.	[ { "ade": "papular eruption", "drug": "Methotrexate" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: DISCUSSION: Methotrexate-induced papular eruption is rarely reported shortly after beginning methotrexate therapy in patients with acute exacerbation of collagen vascular diseases.", "role": "user" }, {...
We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.	[ { "ade": "teratogenicity", "drug": "isotretinoin" }, { "ade": "agenesis of the cerebellar vermis", "drug": "isotretinoin" }, { "ade": "multiple leptomeningeal neuroglial heterotopias", "drug": "isotretinoin" }, { "ade": "hydrocephalus", "drug": "isotretinoin" }, { ...	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the c...
Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.	[ { "ade": "anemia", "drug": "enalapril" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.", "role": "user" }, { "content": "Drug: enalapril, ADE: anemia", "role": "assistant" ...
Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation.	[ { "ade": "hemorrhage", "drug": "Pseudoephedrine" }, { "ade": "cerebral vascular malformation", "drug": "Pseudoephedrine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation.", "role": "user" }, { "content": "Drug: Pseudoephedrine, ADE: hemorrhage; Drug: Pseudoephedrine, ADE: cerebral va...
CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.	[ { "ade": "asthma attack", "drug": "verapamil" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustai...
We hypothesize that capecitabine-induced headache is vascular in nature.	[ { "ade": "headache", "drug": "capecitabine" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: We hypothesize that capecitabine-induced headache is vascular in nature.", "role": "user" }, { "content": "Drug: capecitabine, ADE: headache", "role": "assistant" } ]
A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy.	[ { "ade": "aseptic pleuropericarditis", "drug": "methotrexate" } ]	[ { "content": "Extract the drug and adverse effect mentioned in the following clinical text. ### TEXT: A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy.", "role": "user" }, { "content": "Drug: methotrexate, ADE: aseptic pleuropericarditis", ...