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10.1038/s41586-019-1004-y
Cancer most frequently spreads to the liver; here's why
When cancer spreads to another organ, it most commonly moves to the liver, and now researchers at the Abramson Cancer Center of the University of Pennsylvania say they know why. A new study, published today in Nature, shows hepatocytes—the chief functional cells of the liver—are at the center of a chain reaction that m...
Researchers at the University of Pennsylvania's Abramson Cancer Center have discovered why the liver is a common site for cancer to spread, and how to prevent it. The study, published in Nature, found that hepatocytes, the main functional cells of the liver, play a key role in making the liver susceptible to cancer cel...
None
Abstract The liver is the most common site of metastatic disease 1 . Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a ‘pro-metastatic’ niche that supports the spread of tumour cells to the liver ...
None
[]
[]
[]
SciNews
Medicine
Hepatocytes direct the formation of a pro-metastatic niche in the liver, Nature (2019). DOI: 10.1038/s41586-019-1004-y , www.nature.com/articles/s41586-019-1004-y Journal information: Nature
http://dx.doi.org/10.1038/s41586-019-1004-y
https://medicalxpress.com/news/2019-03-cancer-frequently-liver.html
Researchers at the University of Pennsylvania's Abramson Cancer Center have discovered why the liver is a common site for cancer to spread, and how to prevent it. The study, published in Nature, found that hepatocytes, the main functional cells of the liver, play a key role in making the liver susceptible to cancer cel...
Researchers at the University of Pennsylvania's Abramson Cancer Center have discovered why the liver is a common site for cancer to spread, and how to prevent it. The study, published in Nature, found that hepatocytes, the main functional cells of the liver, play a key role in making the liver susceptible to cancer cel...
{ "reasons": "The press release provides a detailed explanation of how inflammation in the liver creates an environment conducive to cancer spread, mentioning the role of proteins like STAT3 and SAA, and the impact of blocking IL-6. It also discusses potential broader societal implications through conditions like obe...
{ "reasons": "The press release mentions previous research related to the seed-and-soil hypothesis but does not provide details on how this study differs or builds upon the existing work. It highlights the study's findings but lacks specific comparisons to other studies on cancer spread to the liver. Therefore, while...
{ "reasons": "The press release effectively simplifies complex scientific concepts through clear explanations and analogies. It avoids overly technical language where possible and provides sufficient background information to make the study's findings accessible to the public.", "score": 5 }
2.5
Abstract The liver is the most common site of metastatic disease 1 . Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a ‘pro-metastatic’ niche that supports the spread of tumour cells to the liver ...
[SCIENTIFIC-PAPER]: Abstract The liver is the most common site of metastatic disease 1 . Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a ‘pro-metastatic’ niche that supports the spread of tumour...
[SCIENTIFIC-PAPER]: Abstract The liver is the most common site of metastatic disease 1 . Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a ‘pro-metastatic’ niche that supports the spread of tumour...
</think> ### Main Questions Answered in the [JOURNALISTIC-REPORT]: 1. Why is the liver the most common site for cancer metastasis? 2. What role do hepatocytes play in creating a pro-metastatic niche in the liver? 3. How does the IL-6–STAT3–SAA signaling pathway contribute to liver metastasis? 4. What are the implicati...
[ { "author": "Journalist", "text": " Dr. Beatty, the study reveals that hepatocytes are central to creating a pro-metastatic niche in the liver. Can you explain why the liver is the most common site for cancer metastasis?" }, { "author": "Researcher", "text": " Thank you for the question. The liv...
10.1038/s41586-022-05448-9
New genomic variants associated with CHIP identified
"A team of researchers at Regeneron Pharmaceuticals has identified new genomic variants associated w(...TRUNCATED)
"A team of researchers at Regeneron Pharmaceuticals has identified new genomic variants associated w(...TRUNCATED)
None
"Abstract Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been a(...TRUNCATED)
None
[]
[]
[]
SciNews
Medicine
"Michael D. Kessler et al, Common and rare variant associations with clonal haematopoiesis phenotype(...TRUNCATED)
https://dx.doi.org/10.1038/s41586-022-05448-9
https://medicalxpress.com/news/2022-12-genomic-variants-chip.html
"A team of researchers at Regeneron Pharmaceuticals has identified new genomic variants associated w(...TRUNCATED)
"A team of researchers at Regeneron Pharmaceuticals has identified new genomic variants associated w(...TRUNCATED)
{"reasons":"The press release discusses the societal impact of the research by highlighting the pote(...TRUNCATED)
{"reasons":"The press release provides a detailed explanation of the research's context by mentionin(...TRUNCATED)
{"reasons":"The press release explains complex terms like 'genomic variants' and 'clonal hematopoies(...TRUNCATED)
2.5
"Abstract Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been a(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract Clonal haematopoiesis involves the expansion of certain blood cell li(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract Clonal haematopoiesis involves the expansion of certain blood cell li(...TRUNCATED)
"</think>\n\n### Main Questions Answered in the [JOURNALISTIC-REPORT]:\n\n1. What is clonal hematopo(...TRUNCATED)
[{"author":"Journalist","text":" \nDr. [Researcher's Name], thank you for joining us. Your study on(...TRUNCATED)
10.1038/s41598-020-72798-7
Surgical, N95 masks block most particles, homemade cloth masks release their own
"Laboratory tests of surgical and N95 masks by researchers at the University of California, Davis, s(...TRUNCATED)
"Researchers at the University of California, Davis, have conducted laboratory tests to compare the (...TRUNCATED)
None
"Abstract The COVID-19 pandemic triggered a surge in demand for facemasks to protect against disease(...TRUNCATED)
None
[]
[]
[]
SciNews
Medicine
"Sima Asadi et al. Efficacy of masks and face coverings in controlling outward aerosol particle emis(...TRUNCATED)
http://dx.doi.org/10.1038/s41598-020-72798-7
https://medicalxpress.com/news/2020-09-surgical-n95-masks-block-particles.html
"Researchers at the University of California, Davis, have conducted laboratory tests to compare the (...TRUNCATED)
"Researchers at the University of California, Davis, have conducted laboratory tests to compare the (...TRUNCATED)
{"reasons":"The press release provides a detailed explanation of the societal impact by discussing h(...TRUNCATED)
{"reasons":"The press release provides specific information about previous studies on particle emiss(...TRUNCATED)
{"reasons":"The press release uses straightforward language to explain the study, avoiding overly te(...TRUNCATED)
3
"Abstract The COVID-19 pandemic triggered a surge in demand for facemasks to protect against disease(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract The COVID-19 pandemic triggered a surge in demand for facemasks to pr(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract The COVID-19 pandemic triggered a surge in demand for facemasks to pr(...TRUNCATED)
"</think>\n\n### Main Questions Answered in the [JOURNALISTIC-REPORT]:\n\n1. How effective are surgi(...TRUNCATED)
[{"author":"Journalist","text":" Dr. Ristenpart, your study shows that surgical masks and N95 respir(...TRUNCATED)
10.1038/nnano.2015.106
Varying the sliding properties of atoms on a surface
"It's possible to vary (even dramatically) the sliding properties of atoms on a surface by changing (...TRUNCATED)
"Researchers have discovered that the sliding properties of atoms on a surface can be dramatically v(...TRUNCATED)
None
"Abstract The inertial sliding of physisorbed submonolayer islands on crystal surfaces contains unex(...TRUNCATED)
None
[]
[]
[]
SciNews
Nano
"\"Frictional transition from superlubric islands to pinned monolayers.\" Nature Nanotechnology (201(...TRUNCATED)
http://dx.doi.org/10.1038/nnano.2015.106
https://phys.org/news/2015-06-varying-properties-atoms-surface.html
"Researchers have discovered that the sliding properties of atoms on a surface can be dramatically v(...TRUNCATED)
"Researchers have discovered that the sliding properties of atoms on a surface can be dramatically v(...TRUNCATED)
{"reasons":"The press release provides a detailed explanation of how varying the size and compressio(...TRUNCATED)
{"reasons":"The press release provides some context regarding previous research by explaining the co(...TRUNCATED)
{"reasons":"The press release effectively explains complex concepts using analogies, such as compari(...TRUNCATED)
2.5
"Abstract The inertial sliding of physisorbed submonolayer islands on crystal surfaces contains unex(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract The inertial sliding of physisorbed submonolayer islands on crystal s(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract The inertial sliding of physisorbed submonolayer islands on crystal s(...TRUNCATED)
"</think>\n\n### Main Questions Answered in the [JOURNALISTIC-REPORT]:\n1. What is the relationship (...TRUNCATED)
[{"author":"Journalist","text":" Dr. Mistura, the study shows that the sliding properties of xenon i(...TRUNCATED)
10.1038/s41467-020-15707-w
Whole genome sequencing reveals genetic structural secrets of schizophrenia
"Most research about the genetics of schizophrenia has sought to understand the role that genes play(...TRUNCATED)
"A recent study published in Nature Communications has shed new light on the genetics of schizophren(...TRUNCATED)
None
"Abstract Despite considerable progress in schizophrenia genetics, most findings have been for large(...TRUNCATED)
None
[]
[]
[]
SciNews
Medicine
"Matthew Halvorsen et al, Increased burden of ultra-rare structural variants localizing to boundarie(...TRUNCATED)
http://dx.doi.org/10.1038/s41467-020-15707-w
https://medicalxpress.com/news/2020-04-genome-sequencing-reveals-genetic-secrets.html
"A recent study published in Nature Communications has shed new light on the genetics of schizophren(...TRUNCATED)
"A recent study published in Nature Communications has shed new light on the genetics of schizophren(...TRUNCATED)
{"reasons":"The press release highlights the potential for new treatments and precision medicine app(...TRUNCATED)
{"reasons":"The press release provides a detailed explanation of prior research on schizophrenia gen(...TRUNCATED)
{"reasons":"The press release explains complex concepts like structural variants and TADs with basic(...TRUNCATED)
2.5
"Abstract Despite considerable progress in schizophrenia genetics, most findings have been for large(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract Despite considerable progress in schizophrenia genetics, most finding(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract Despite considerable progress in schizophrenia genetics, most finding(...TRUNCATED)
"</think>\n\n**Extracted Main Questions Answered in the [JOURNALISTIC-REPORT]:**\n\n1. What is the r(...TRUNCATED)
[{"author":"Journalist","text":" Dr. Szatkiewicz, your study suggests that rare structural variants (...TRUNCATED)
10.1007/s11109-016-9332-1
Divided parties rarely win presidential elections, study shows
"Divided political parties rarely win presidential elections, according to a study by political scie(...TRUNCATED)
"A study by political science researchers at the University of Georgia found that divided political (...TRUNCATED)
None
"Abstract In presidential nomination campaigns, individual state primaries and a national competitio(...TRUNCATED)
None
[]
[]
[]
SciNews
Other
"Paul-Henri Gurian et al. National Party Division and Divisive State Primaries in U.S. Presidential (...TRUNCATED)
http://dx.doi.org/10.1007/s11109-016-9332-1
https://phys.org/news/2016-03-parties-rarely-presidential-elections.html
"A study by political science researchers at the University of Georgia found that divided political (...TRUNCATED)
"A study by political science researchers at the University of Georgia found that divided political (...TRUNCATED)
{"reasons":"The press release provides specific data and examples about how party division affects e(...TRUNCATED)
{"reasons":"The press release does mention related research when discussing previous findings about (...TRUNCATED)
{"reasons":"The press release effectively communicates the study's findings using accessible languag(...TRUNCATED)
3
"Abstract In presidential nomination campaigns, individual state primaries and a national competitio(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract In presidential nomination campaigns, individual state primaries and (...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract In presidential nomination campaigns, individual state primaries and (...TRUNCATED)
"</think>\n\n### Main Questions Answered in the [JOURNALISTIC-REPORT]:\n\n1. **What is the relations(...TRUNCATED)
[{"author":"Journalist","text":" Dr. Gurian, your study suggests that divided political parties rare(...TRUNCATED)
10.1038/s43247-021-00248-x
New study findings could help improve flood projections
"Climate change will lead to more and stronger floods, mainly due to the increase of more intense he(...TRUNCATED)
"A team of scientists led by Dr. Manuela Brunner and Prof. Dr. Ralf Ludwig has shed light on how cli(...TRUNCATED)
None
"Abstract Precipitation extremes will increase in a warming climate, but the response of flood magni(...TRUNCATED)
None
[]
[]
[]
SciNews
Earth
"Manuela I. Brunner et al, An extremeness threshold determines the regional response of floods to ch(...TRUNCATED)
http://dx.doi.org/10.1038/s43247-021-00248-x
https://phys.org/news/2021-08-new-study-findings-could-help.html
"A team of scientists led by Dr. Manuela Brunner and Prof. Dr. Ralf Ludwig has shed light on how cli(...TRUNCATED)
"A team of scientists led by Dr. Manuela Brunner and Prof. Dr. Ralf Ludwig has shed light on how cli(...TRUNCATED)
{"reasons":"The press release primarily focuses on explaining the scientific findings of the study, (...TRUNCATED)
{"reasons":"The press release provides context by mentioning that the study addresses an aspect of e(...TRUNCATED)
{"reasons":"The press release effectively explains complex climate concepts through examples and ana(...TRUNCATED)
2.5
"Abstract Precipitation extremes will increase in a warming climate, but the response of flood magni(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract Precipitation extremes will increase in a warming climate, but the re(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract Precipitation extremes will increase in a warming climate, but the re(...TRUNCATED)
"</think>\n\n### Extracted Main Questions Answered in the [JOURNALISTIC-REPORT]:\n\n1. How do weaker(...TRUNCATED)
[{"author":"Journalist","text":" Dr. Brunner, the study highlights a distinction between weaker, mor(...TRUNCATED)
10.1038/s41586-019-1579-3
How sleepless nights compromise the health of your gut
"It is well known that individuals who work night shifts or travel often across different time zones(...TRUNCATED)
"Researchers at the Champalimaud Centre for the Unknown in Lisbon, Portugal, have discovered that th(...TRUNCATED)
None
"Abstract Group 3 innate lymphoid cells (ILC3s) are major regulators of inflammation, infection, mic(...TRUNCATED)
None
[]
[]
[]
SciNews
Medicine
"Light-entrained and brain-tuned circadian circuits regulate ILC3 and gut homeostasis, Nature (2019)(...TRUNCATED)
http://dx.doi.org/10.1038/s41586-019-1579-3
https://medicalxpress.com/news/2019-09-sleepless-nights-compromise-health-gut.html
"Researchers at the Champalimaud Centre for the Unknown in Lisbon, Portugal, have discovered that th(...TRUNCATED)
"Researchers at the Champalimaud Centre for the Unknown in Lisbon, Portugal, have discovered that th(...TRUNCATED)
{"reasons":"The press release explains the societal impact by discussing how disruptions in the circ(...TRUNCATED)
{"reasons":"The press release adequately places the study within the broader scientific context by m(...TRUNCATED)
{"reasons":"The press release effectively communicates the research by avoiding overly technical lan(...TRUNCATED)
3
"Abstract Group 3 innate lymphoid cells (ILC3s) are major regulators of inflammation, infection, mic(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract Group 3 innate lymphoid cells (ILC3s) are major regulators of inflamm(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract Group 3 innate lymphoid cells (ILC3s) are major regulators of inflamm(...TRUNCATED)
"</think>\n\n### Extracted Main Questions from the [JOURNALISTIC-REPORT]:\n\n1. What is the relation(...TRUNCATED)
[{"author":"Journalist","text":" Dr. Veiga-Fernandes, the study reveals a fascinating link between t(...TRUNCATED)
www.nature.com/articles/s41598-020-59797-4
"First genetic evidence of resistance in some bats to white-nose syndrome, a devastating fungal dise(...TRUNCATED)
"A new study from University of Michigan biologists presents the first genetic evidence of resistanc(...TRUNCATED)
"A new study by University of Michigan biologists has found genetic evidence of resistance in some b(...TRUNCATED)
None
"Abstract The degree to which species can rapidly adapt is key to survival in the face of climatic a(...TRUNCATED)
None
[]
[]
[]
SciNews
Biology
"Giorgia G. Auteri et al. Decimated little brown bats show potential for adaptive change, Scientific(...TRUNCATED)
https://www.nature.com/articles/s41598-020-59797-4
https://phys.org/news/2020-02-genetic-evidence-resistance-white-nose-syndrome.html
"A new study by University of Michigan biologists has found genetic evidence of resistance in some b(...TRUNCATED)
"A new study by University of Michigan biologists has found genetic evidence of resistance in some b(...TRUNCATED)
{"reasons":"The press release explains how the research contributes to understanding genetic resista(...TRUNCATED)
{"reasons":"The press release provides detailed scientific context by mentioning prior research on w(...TRUNCATED)
{"reasons":"The press release effectively communicates the study's findings without using overly tec(...TRUNCATED)
2.5
"Abstract The degree to which species can rapidly adapt is key to survival in the face of climatic a(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract The degree to which species can rapidly adapt is key to survival in t(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract The degree to which species can rapidly adapt is key to survival in t(...TRUNCATED)
"</think>\n\n### Extracted Main Questions from the [JOURNALISTIC-REPORT]:\n\n1. What evidence did th(...TRUNCATED)
[{"author":"Journalist","text":" Dr. Auteri, your study found genetic evidence of resistance in some(...TRUNCATED)
10.1038/s42003-020-01308-2
Taking the itch out of cancer immunotherapy
"Using the body's immune system to fight cancer has great potential, but can also bring serious side(...TRUNCATED)
"Researchers from Japan have discovered the mechanism behind a common side effect of immunotherapy w(...TRUNCATED)
None
"Abstract Use of immune checkpoint inhibitors that target programmed cell death-1 (PD-1) can lead to(...TRUNCATED)
None
[]
[]
[]
SciNews
Medicine
"Ryota Tanaka et al. Activation of CD8 T cells accelerates anti-PD-1 antibody-induced psoriasis-like(...TRUNCATED)
http://dx.doi.org/10.1038/s42003-020-01308-2
https://medicalxpress.com/news/2020-10-cancer-immunotherapy.html
"Researchers from Japan have discovered the mechanism behind a common side effect of immunotherapy w(...TRUNCATED)
"Researchers from Japan have discovered the mechanism behind a common side effect of immunotherapy w(...TRUNCATED)
{"reasons":"The press release effectively discusses the societal impact of the research by detailing(...TRUNCATED)
{"reasons":"The press release provides context by explaining that PD-1 inhibitors can cause immune-r(...TRUNCATED)
{"reasons":"The press release effectively communicates complex scientific concepts using clear expla(...TRUNCATED)
2.5
"Abstract Use of immune checkpoint inhibitors that target programmed cell death-1 (PD-1) can lead to(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract Use of immune checkpoint inhibitors that target programmed cell death(...TRUNCATED)
"[SCIENTIFIC-PAPER]:\nAbstract Use of immune checkpoint inhibitors that target programmed cell death(...TRUNCATED)
"</think>\n\n### Main Questions Answered in the [JOURNALISTIC-REPORT]:\n1. What causes the skin reac(...TRUNCATED)
[{"author":"Journalist","text":" \nDr. Okiyama, the study identifies that anti-PD-1 antibody-induce(...TRUNCATED)
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