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6,100
Based on recent knowledge, cells may not opt for the germline mutation in an attempt to counteract haploinsufficiency, which, as shown for BRCA1, results in genomic instability and premature senescence in human breast epithelial cells [29].
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6,101
…neurotoxin 1-methyl-4-pheyl-1,2,3,6tetrahydropyridine (MPTP) to mimic the key clinical and pathological features of PD in man and subhuman primate species has provided a useful model in which to study treatment strategies for PD (Ballard et al., 1985; Burns et al., 1983; Crossman et al., 1987).
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6,102
In accordance with previous studies, we used a cut-off score of .85 to assign participants to the high versus low cardiac perception group (e.g. Montoya et al., 1993; Pollatos et al., 2005; Schandry et al., 1986).
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method
6,103
Concentration data were requested for As, Cd, Cu, Fe, Mn, Ni, Pb and Zn, which represent the most common (and most commonly measured) pollutants discharged from abandoned metal mines in England and Wales (Mayes et al., 2009).
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method
6,104
…some extensions of the above factorization methods are proposed, including the TrAnsfer Learning for MUltiple Domains (TALMUD) (Moreno et al., 2012), the extended Cluster-level Latent Factor Model (CLFM) (GAO ET AL., 2013B;A) and the Cross-Domain Triadic Factorization (CDTF) (Hu et al., 2013).
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method
6,105
P-VS plots of SA1 from 11 to 60 GPa are fitted with a fourth order polynomial (R 2 = 0.9933) and P-VS plots of SA2 from 10 to 59 GPa are fitted with a quadratic function (R2 = 0.9957) also observed in SiO2 glass (Murakami and Bass 2010) and MgSiO3 glass (Murakami and Bass 2011).
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6,106
To facilitate detection of metagenomic SSU rRNA sequences matching sequences in the SILVA database (release 126) [12], all bacterial SSU rRNA sequences ≥ 1200 bp deposited in the SILVA database (release 126) [12] were added to the initial data set and a second clustering at 97% and consecutively 85% sequence similarity threshold was performed (version 9.
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method
6,107
quency (2–32 kHz), and the range of BFs mapped in all regions covered the range of pinna-related frequency and ILD cues in the rat (Koka et al., 2008; Tollin and Koka, 2009).
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6,108
The effect of O2 appears to be mediated at least in part by prolyl 4-hydroxylation of Skp1, because elevated O2 levels are required by phyA – and Skp1-overexpression strains, and lower O2 is required by PhyA overexpression and Skp1B cells [10,24].
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6,109
Availability of high biological value of animal proteins, essential amino acids and fatty acids, vitamins and other nutrients are the other reasons to ensure its popularity among masses (Biesalski, 2005).
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6,110
shown to produce similar outcomes to FU-based chemotherapy.(122,123) The next major advance came with the addition of bevaci-
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method
6,111
Another approach is to fit a distribution of selective effects to the SFS (Eyre-Walker et al., 2006; Keightley and Eyre-Walker, 2007; Boyko et al., 2008; Schneider et al., 2011).
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6,112
All of the aforementioned methodologies assign a primary role to observation (Baker, 2006), which is defined as the “systematic recording of observable phenomena or behavior JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY in a natural setting” (Gorman & Clayton, 2005, p. 40).
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6,113
The study results support findings from similar studies using VIA screening, which have demonstrated the effectiveness, safety, and feasibility of a screening program based on VIA testing [2–12,16].
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result
6,114
Hennessy and Milner showed in (Hennessy and Milner, 1985) that, over imagefinite labelled transition systems, strong bisimilarity also coincides with the relation
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6,115
In this section, we evaluate our approach on two challenging datasets, i.e., UCF50 [13] and HMDB51 [14].
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method
6,116
, 2009; Kelly and Simpson, 2001) and to develop practitioner roles (Williamson et al., 2004).
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6,117
Performing routine screening for asymptomatic CAD in all patients with type 2 DM is debatable for several reasons (26-28).
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6,118
In addition, some examined the appropriate monitoring frames to reliably estimate habitual physical behaviour intensities individually [5, 6].
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6,119
This concurs with other data on Myh13 expression (6) and may explain this transcript’s sensitivity to postnatal visual/vestibular deprivation (5, 7).
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result
6,120
The gross distribution of PLCb1-immunohistochemical staining in the rat central nervous system described here is consistent with previous evidences in mice, showing a predominant expression of PLCb1 protein (Gerfen et al., 1988; Hannan et al., 1998; Hozumi et al., 2008; Fukaya et al., 2008) in cerebral cortex, caudate–putamen and hippocampus, along with lower levels in diencephalon, brainstem and cerebellum.
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6,121
The participants completed the Hand10, the DASH-JSSH [9, 10], and the Revised Hasegawa Dementia Scale (HDSR) questionnaires [11] twice, with an average interval of 10 days.
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method
6,122
…2005), wild fires (Gancet et al., 2005; Merino et al., 2006), victims (Kuiper and NadjmTehrani, 2006; Murphy et al., 2008), objects (Stirling et al., 2010) and other targets of interest (Altshuler et al., 2008; Cole et al., 2006; Ruini and Cangelosi, 2009; Sauter et al., 2005; Yang et al., 2005).
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6,123
We adapted our paradigm from a recent study that reported significantly better recall of prices of everyday items in healthy adults when price information was consistent with prior knowledge than when it was inconsistent (Castel, 2005).
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6,124
The small proportion of 50-RACE products containing exon 1c that we previously reported for human and mouse was an underestimate caused by the difficulty of amplification of this 93% GC fragment (Drews et al. 2005).
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6,125
Induction of C1qa in the CNS promotes synapse elimination and synaptic dysfunction during development, neurodegenerative diseases such as glaucoma and AD, and aging [29,30,31,32,74].
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6,126
They are applicable in scenarios such as designing questions for reading comprehension (Du et al., 2017; Zhou et al., 2017a; Yuan et al., 2017), and justifying the visual understanding by generating questions to a given image (video) (Mostafazadeh et al.
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6,127
Previously published data for both fungi and bacteria are in agreement with these results (Moleyar and Narasimham 1986; Carson and Riley 1995; Griffin et al. 1999; Adegoke et al. 2000; Cox et al. 2001; Inouye et al. 2001).
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6,128
Care giving is defined as the process of undertaking the activities and responsibilities of care giving (Stetz & Brown, 1997).
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6,129
These concentrations are similar to those determined in prior tivozanib monotherapy trials [5, 6].
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6,130
Two such factors predicting enhanced Delta REM (and thereby predicting substantial REM rebound) as suggested in several studies include: 1) a lower amount of REM sleep on diagnostic PSG (strong association) and 2) a higher severity of OSA as noted by the AHI during diagnostic PSG (weak association, if any).
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6,131
…procedures for 2-dimensional gel electrophoresis (2DE) were based on those described previously (Cruz-Topete et al. 2011a; Cruz-Topete et al. 2011b; Cruz-Topete et al. 2011c; Christensen et al. 2011; Ding et al. 2011; Ding and Kopchick 2011; Okada et al. 2010; Sackmann-Sala et al. 2009; List et…
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method
6,132
Habitat use was simply defined as the percent of observed pairs associated with a given habitat type over the total number of pairs detected in all habitats (Manly et al. 2002).
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6,133
Communitybased cross-sectional surveys in Philippines,[21] Nigeria,[22] Bangladesh,[15] and India[19] have also reported similar findings [Table 1].
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6,134
The author of case series of human patients stated that as the window width was increased, the foreign bodies were more easily identified and better differentiated from a gas or fluid build up due to the wood’s absorptive characteristics and the duration of the injury.(15)
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6,135
, 1989), numerous inositol trisphosphate receptor genes have been identified and grouped into a family of transient receptor potential (TRP) channels (Vannier et al., 1998; Blondel et al., 1993; Maranto, 1994; Ross et al., 1992; Sudhof et al., 1991).
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6,136
using the Reading Span [40], and the Digit Span, a subtest of the WAIS; Visual-motor processing and attention (VSM), was assessed with the Digit Symbol Test, a subtest of the WAIS, the Trailmaking test, part B (TMT; [41]) and the Color-WordInterference test [42], one of the most widely used paradigms for the evaluation of selective attention; Abstraction and conceptual flexibility (ABS) were assessed by means of the modified Wisconsin Card Sorting Test (number categories and perseverative
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method
6,137
[85], the technique for transforming Overlapping B-trees to a STAM can also be applied to other classical temporal access methods [84], especially to those that are modifications of the B-tree family.
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method
6,138
In the yeast Sac. cerevisiae, mutation in genes BNI1, BUD3, BUD6 and SPA2, which regulate polarity and proper cell development, triggers cellpolarity phenotypes (Amberg et al., 1997; Chant et al., 1995; Sagot et al., 2002; Sheu et al., 1998).
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6,139
Presumably, NusA stimulates formation of the DNA/RNA hybrid that substitutes for the terminator hairpin (126), consistent with previous views of NusA function (41, 138).
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6,140
IKr reduction may be caused by dual mechanisms, acute inhibition of hERG channels and chronic drug-induced disruption of hERG protein trafficking into the cell surface membrane (Ficker et al. 2004; Cordes et al. 2005; Kuryshev et al. 2005; Wible et al. 2005; Rajamani et al. 2006; Thomas et al. 2006; Guo et al. 2007; Takemasa et al. 2007; Wang et al. 2007; Van der Heyden et al. 2008; Obers et al. 2010; Staudacher et al. 2010).
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6,141
It performs three fundamental functions: it binds a spermatozoon—thus preventing interspecies fertilization; it induces the acrosome reaction of the spermatozoon; and, finally, immediately after fertilization, it prevents polyspermy (Baker et al. 2000; Bleil and Wassarman 1990; Herrler and Beier 1999; Serrano and Garcia-Suarez 2001;Thaler and Cardullo 2002; Yanagimachi 1994; Zhao and Dean 2002).
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6,142
Further evidence is provided by Mammucari et al who have discovered that integration of the Notch and NFAT/calcineurin signaling pathways seems to be important for keratinocyte differentiation [6] and Zanotti et al who have identified Notch and NFAT signaling as reciprocally inhibiting pathways that together regulate osteoblast function [7].
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background
6,143
The pCEFLHA-HMGA1, pCEFL-HA-HMGA2, pCEFL-HA-HMGA1 (1–43) and pCEFL-HA-HMGA2 (1–73) vectors were previously described (Fedele et al., 2006; Pierantoni et al., 2001; Pentimalli et al., 2008).
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6,144
The 4-year survival of 73% in the AFB/MEVP cohort compares favorably with the long-term survival reported by other centers of excellence.(29,30) Perhaps more importantly, however, the long-term survival demonstrated with the use of AFB/MEVP equates the long-term survival reported by our group after open repair of standard infrarenal aortic aneurysms.
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result
6,145
Instead of atzA, the functional homolog, trzN gene (Mulbry et al. 2002), may be more commonly observed in the environment (Arbeli and Fuentes 2010).
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6,146
[22, 23, 27] In brief, the technician administered a topical anaesthetic to the participant’s eye to temporarily suppress the corneal blink reflex.
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6,147
1 was expressed with ABI1-HA or mER7 control DNA (Yoo et al., 2007) in 3 mL of protoplasts (6 3 105 cells) under standard conditions.
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method
6,148
method developed in [6,8] and improved in [10,18], where we first discretize in space, using a Finite Difference scheme, then discretize in time, using an implicit multistep scheme, of the BDF family (Backward Differentiation Formula).
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method
6,149
The fastq files were trimmed and filtered with skewer [37] and aligned to the Gy14 reference genome with bwa mem [38].
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method
6,150
Some studies suggest a conservative approach (23, 24), while others support more radical treatment (18, 25, 26); there is, however, a lack of studies distinguishing between different types of oral infections.
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6,151
The impact of additional diagnostic technologies is sensitive to the technology’s ability to improve surgical decision-making and the ability of surgery to produce cost-effective outcomes [41].
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6,152
Differences in genetic background and/or testing conditions could also contribute to the modest differences between our locomotor data and that of Tian and coworkers (Tian et al. 1997).
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6,153
This paper reports on the results of studies we have completed in the Victorian (Australia) public health care sector (Bartram et al., 2007, Leggat et al., 2005, 2006, 2008, 2010; Young et al., 2010; Bonias et al., 2010; Stanton et al., 2010).
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6,154
We previously studied laparoscopic ovarian cystectomy using a single ancillary port and we obtained similar results regarding patient satisfaction with the operation scar (Capar et al. 2009).
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6,155
Traditional, dichotomous approaches to studying teams as either dispersed or collocated mask the configuration-based effects highlighted in this study, resulting in an obvious loss of accuracy (O’Leary and Cummings 2007).
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6,156
Conditional double mutants of trf4 with top1-7 showed ribosomal DNA (rDNA) condensation phenotypes (Sadoff et al, 1995; Castano et al, 1996), and were reported to display defects in mitotic segregation (Wang et al, 2000; Edwards et al, 2003).
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6,157
Human epidermal growth factor receptor type 2 (HER2) is located on chromosome 17q21 and is a transmembrane tyrosine kinase growth factor receptor [12].
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6,158
The same results were obtained by Winther and Nathalang [27] and by Knoll-Köhler [14], who did not determine any difference in the anaesthetic action profiles of a 2 and 4% solution of articaine or a 74-mM (=2.4% solution) and a 148-mM (=4
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6,159
Our results concurred with a previous observation in NIH 3T3 cells during adhesion to FN (31), but contrast with the finding in HeLa cells during adhesion to gelatin (44).
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6,160
ICD indication was defined according to Class I recommendations in current clinical guidelines (4,5): chronic LVEF 30% or chronic LVEF 30% to 35% in patients in New York Heart Association functional class II or III.
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method
6,161
MuTAIL is a recent adaptation of this approach to the analysis of Mu insertion sites (Settles et al., 2004, 2007).
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method
6,162
The efficacy is defined in terms of the ARs of the vaccinated and unvaccinated groups [20],
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6,163
From results reported here, and those in previous works (recent works of particular importance to this report are: Chapple and Krans 2004; Krans and Chapple 2005), we have adopted the following conclusions: (1) The reflex generation of force is profoundly nonlinear and the first phase may act like…
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6,164
Autogenous bone grafts are still the most effective bone substitutes and are therefore considered the gold standard [1,2].
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6,165
[20] have reported postoperative results 2 years after Wxation of 200 proximal humerus fractures with the Humerusblock.
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6,166
Thus, Pro accumulation is widely considered an anti-stress indicator (Verbruggen and Hermans 2008).
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6,167
It is safe, however, to conclude that in humans, reciprocity is considered a major value given the importance attached to norms prescribing it (Gouldner 1960) and the function of gratitude (McCullough et al. 2001; Trivers 1971).
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6,168
Hyper-parameter settings: We kept the hyper-parameter setting for the biLSTM transducer similar to the one reported in [5].
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6,169
…2002); (2) spike-frequency adaptation is elicited by phase 1 high-frequency spiking and acts to reduce spike rate during following depolarization (Krans and Chapple 2005); (3) the dynamics of muscle shortening may change with motoneuron frequency and over time when activated (Chapple 1989b;…
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6,170
Because a7 subunits are glycosylated (Gotti et al., 1992; Chen et al., 1998) and possess several phosphorylation consensus sites (Seguela et al.
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6,171
…animal models have shown the antipsychotic and procognitive effects of asenapine (McLean et al. 2010; Marston et al. 2009; Frånberg et al. 2008), which have now been clinically validated in the treatment of acute schizophrenia (Kane et al. 2010; Potkin et al. 2007; Weber and McCormack 2009).
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The ability of last-return LiDAR to provide within-field vegetation height was tested in a study using the Faringdon data by Davenport et al. (2000).
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While explanatory science takes a solution as given, design science commences earlier in the life cycle of a solution; it seeks to develop new solutions (Holmström et al., 2009).
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This model of practice is common for home intravenous therapy programmes in the UK (Nathwani 1995, , Nathwani and Davey 1996, Kayley 2003), however; recently this model has been revaluated (Laupland et al 2002, Cooper 2003).
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In addition, the reduction in belowground carbon/resource inputs from vegetation can lead to competitive exclusion among closely related taxa that share a similar niche, resulting in less phylogenetic clustering (Lekberg et al. 2013).
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We 1Relations between non-adjacent utterances are constrained by the structure of discourse (Webber 1991), and thus less likely than relations between adjacent utterances. assume that the same event can reoccur in different contexts, we are thus studying relations between types of events.
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Putative novel MLVA profiles were given numerical designations, from MLVA-0027 onwards, to follow on from the known 26 MLVA types (MLVA-A to MLVA-Z) [7].
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Oligonucleotides for human INF2 siRNA were previously described in Korobova et al. (2013).
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Macular fixation was determined using the Rodenstock scanning laser ophthalmoscope (SLO; Rodenstock, Germany) with refined software for microperimetry (Software Aachen) [38].
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This experience of a nearly pain-free treatment for patients has also been reported in other studies on daylight PDT [12–15,32–34].
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Consistent with other reports [12, 25, 27], our patients were predominantly Caucasian (100%), myopic (75%) and female (69%).
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Muscle enzymes (lactic dehydrogenase or LDH and creatine kinase or CK) were measured by enzymatic assays (Olympus 640 kits and equipment, Olympus Diagnostica, Hamburg, Germany) only in the marathon protocol, since they were previously found to be unchanged after short-lived exercise (22).
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In patients with late stages of tumorigenesis, TGFB1 may favor a more aggressive phenotype by promoting tumor growth and resistance to apoptosis or by enhancing tumor cell motility and eventually the outgrowth of distant metastases [17].
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The Intercontinental Chemical Transport Experiment B (INTEX-B) aircraft campaign over the North Pacific and western coast of North America made measurements of OH and HO2 (Mao et al., 2009; Singh et al., 2009).
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The spectroscopic results described above parallel closely those reported earlier for C-phycocyanin and its subunits by Glazer et al. (1973), who showed that the long wavelength absorption band of the trimeric and hexameric forms of the protein arises as a consequence of interactions between the chromophores of different monomers, rather than of interactions between chromophores within the cq~ monomer.
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Studies were included according to the following inclusion criteria: (1) prospective or retrospective cohort studies; (2) inclusion of patients with ESRD undergoing hemodialysis or peritoneal dialysis; (3) baseline serum ALP levels as exposure; and (4) provided multiple adjusted odds ratio (OR) or hazard ratio (HR) and 95% confidence interval (CI) of cardiovascular or all-cause mortality comparing the highest with the reference lower serum ALP levels.
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…N I N G M E M O R Y www.learnmem.org ies that used object-based DNMS tasks (Aggleton et al. 1986; Rothblat and Kromer 1991; Jackson-Smith et al. 1993; Kesner et al. 1993; Rawlins et al. 1993; Shaw and Aggleton 1993; Yee and Rawlins 1994; Glenn and Mumby 1996; Mumby et al. 1996; Cassaday and…
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The mesenchymal type has been reported to present the worst prognostic among GBM subtypes (28, 29).
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OX1 expression can be upregulated on microglia during CNS inflammation (Sedgwick et al., 1991) and there was some overlap of OX1 fluorescence between our FSChigh OX1high and FSClow OX1low populations.
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CVL1 and CVP2 dephosphorylate PtdIns(4,5)P2 and, by acting in opposition to PIP-kinases (Carland and Nelson, 2009; Carland and Nelson, 2004), help tightly regulate the levels of PtdIns(4,5)P2 necessary for initiation of endocytosis during PIN1 trafficking (Rodriguez-Villalon et al., 2015; Tejos et…
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Although this study was not designed to assess efficacy, repeat imaging was performed and evaluated using RECIST every two cycles.
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Dialog Acts are annotated on functional segments (FSs) (Bunt et al., 2010; Bunt et al., 2012): minimal spans of text that express one or more dialog intents.
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In agreement with results from a previous study in this laboratory (17), administration of 2 mg/kg body wt MDP significantly inhibited food intake in the second experiment.
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Moreover, comparable results were obtained in an in vivo imaging study on mice, which was performed with the highly resolving U-SPECT [30]; in this investigation, intraperitoneal application of 2.5 mg/kg amphetamine led to a 27% reduction of [123I]IBZM binding relative to baseline.
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Some investigators have demonstrated only brainstem LBD using histochemical methods [43] while others have demonstrated limbic LBD [41], and still others neocortical LBD [54, 82] in cases of AD caused by mutations in APP.
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Intact, beating hearts from young ( 4 wk, n 37) and old ( 52 wk, n 37) guinea pigs were prepared by the Langendorff method and perfused with Krebs-Ringer (KR) solution as previously described by us in detail (1, 2, 9, 10, 35, 37, 38).
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Several studies previously reported that the abundant proteins or LPS on the surface of outer membrane were suitable as targets for vaccine and diagnosis of leptospirosis such as outer membrane proteins [38,39], LIC11207 [40], OmpL1 [41,42], MPL17 and MPL21 [43], HbpA [44], LigA [45], LP29 and LP49 [46], LipL32 [47-50], LipL21 [50,51], LipL41 [42], flagellin protein [52].
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Moreover, this idea is supported by a recently published meta-analysis that analyzed 11 studies and depicted that long-term and well-described short-term outcomes suggest that colonic stenting as a bridge to surgery could be a promising alternative strategy for patients with MLBO.16 Meanwhile, a Danish nationwide cohort study reported a higher 5-year recurrence risk in the SEMS group (39% vs. 30%), but with similar 5-year overall survival rate.17 Whether the increased recurrence risk of patients with colonic stenting compared to those that performed primary surgery is a result of perforation or other prognostic factors, it is still unknown.
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The ENCODE findings were recently expanded by Xu et al [42] demonstrating a major role of histone modifications in developmentally regulated globin gene expression.
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