input stringlengths 24 527 | output unknown | schema unknown |
|---|---|---|
OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "induced",
"start": 162,
"end": 169
},
"arguments": [
{
"role": "Treatment",
"text": "insulin",
"start": 154,
"end": 161
},
... | {
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{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "develop",
"start": 160,
"end": 167
},
"arguments": [
{
"role": "Subject",
"text": "women of reproductive age",
"start": 72,
"end": 97
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Phenobarbital hepatotoxicity in an 8-month-old infant. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "in",
"start": 29,
"end": 31
},
"arguments": [
{
"role": "Subject",
"text": "an 8-month-old infant",
"start": 32,
"end": 53
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "following",
"start": 100,
"end": 109
},
"arguments": [
{
"role": "Treatment",
"text": "intrathecal methotrexate and cytarabine",
"start": 110,
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
According to the Naranjo probability scale, flecainide was the probable cause of the patient's delirium; the Horn Drug Interaction Probability Scale indicates a possible pharmacokinetic drug interaction between flecainide and paroxetine. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "cause",
"start": 72,
"end": 77
},
"arguments": [
{
"role": "Treatment",
"text": "flecainide",
"start": 44,
"end": 54
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Contact dermatitis due to budesonide: report of five cases and review of the Japanese literature. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "due",
"start": 19,
"end": 22
},
"arguments": [
{
"role": "Effect",
"text": "Contact dermatitis",
"start": 0,
"end": 18
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "following",
"start": 82,
"end": 91
},
"arguments": [
{
"role": "Subject",
"text": "a Japanese patient with vivax malaria",
"start": 44,
"en... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "related",
"start": 47,
"end": 54
},
"arguments": [
{
"role": "Subject",
"text": "three cases",
"start": 10,
"end": 21
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "symptoms of",
"start": 29,
"end": 40
},
"arguments": [
{
"role": "Subject",
"text": "Four patients",
"start": 0,
"end": 13
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Minocycline as a cause of drug-induced autoimmune hepatitis. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "induced",
"start": 31,
"end": 38
},
"arguments": [
{
"role": "Effect",
"text": "autoimmune hepatitis",
"start": 39,
"end": 59
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "after",
"start": 33,
"end": 38
},
"arguments": [
{
"role": "Effect",
"text": "Secondary acute myeloid leukemia",
"start": 0,
"end": 32
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Allergic contact angioedema to benzoyl peroxide. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "to",
"start": 28,
"end": 30
},
"arguments": [
{
"role": "Effect",
"text": "Allergic contact angioedema",
"start": 0,
"end": 27
},... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "develop",
"start": 61,
"end": 68
},
"arguments": [
{
"role": "Subject",
"text": "A 60-year-old white man with chronic bronchitis",
"start": 0,
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "induced",
"start": 7,
"end": 14
},
"arguments": [
{
"role": "Treatment",
"text": "L-DOPA",
"start": 0,
"end": 6
},
{
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "contributed",
"start": 43,
"end": 54
},
"arguments": [
{
"role": "Treatment",
"text": "foscarnet",
"start": 33,
"end": 42
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Acute drug induced hepatitis due to erlotinib. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "due",
"start": 29,
"end": 32
},
"arguments": [
{
"role": "Effect",
"text": "Acute drug induced hepatitis",
"start": 0,
"end": 28
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "after",
"start": 103,
"end": 108
},
"arguments": [
{
"role": "Subject",
"text": "3 diabetic patients",
"start": 12,
"end": 31
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account... | {
"events": {
"adverse event": [
{
"trigger": {
"text": "induced",
"start": 30,
"end": 37
},
"arguments": [
{
"role": "Treatment",
"text": "MTX",
"start": 26,
"end": 29
},
{
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Acute esmolol toxicity may be self-limiting because of its extremely short half-life. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "be",
"start": 27,
"end": 29
},
"arguments": [
{
"role": "Treatment",
"text": "esmolol",
"start": 6,
"end": 13
},
{
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "with",
"start": 16,
"end": 20
},
"arguments": [
{
"role": "Effect",
"text": "development of ovarian endometrioid carcinoma",
"start": 110,
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
The other woman had rheumatoid arthritis and developed acute tubular necrosis after treatment with gentamicin and cefoxitin. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "developed",
"start": 45,
"end": 54
},
"arguments": [
{
"role": "Effect",
"text": "acute tubular necrosis",
"start": 55,
"end": 77
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia). | {
"events": {
"adverse event": [
{
"trigger": {
"text": "had",
"start": 37,
"end": 40
},
"arguments": [
{
"role": "Treatment",
"text": "clindamycin",
"start": 25,
"end": 36
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
A MEDLINE search (1966-January 2009) revealed one in vivo pharmacokinetic study on the interaction between flecainide, a CYP2D6 substrate, and paroxetine, a CYP2D6 inhibitor, as well as 3 case reports of flecainide-induced delirium. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "induced",
"start": 215,
"end": 222
},
"arguments": [
{
"role": "Treatment",
"text": "flecainide",
"start": 204,
"end": 214
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "develops",
"start": 184,
"end": 192
},
"arguments": [
{
"role": "Treatment",
"text": "spironolactone",
"start": 89,
"end": 103
},... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
When these cells are exposed to nicotinic acid, an exaggerated immune response is produced that may lead to pain, redness, and swelling at the injection site. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "produced",
"start": 82,
"end": 90
},
"arguments": [
{
"role": "Treatment",
"text": "nicotinic acid",
"start": 32,
"end": 46
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "reported",
"start": 24,
"end": 32
},
"arguments": [
{
"role": "Effect",
"text": "heatstroke",
"start": 10,
"end": 20
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Paraplegia following intrathecal cytosine arabinoside. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "following",
"start": 11,
"end": 20
},
"arguments": [
{
"role": "Effect",
"text": "Paraplegia",
"start": 0,
"end": 10
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Cimetidine-induced fever. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "induced",
"start": 11,
"end": 18
},
"arguments": [
{
"role": "Treatment",
"text": "Cimetidine",
"start": 0,
"end": 10
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
This case report illustrates the neurotoxicity unique to HDARAC. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "to",
"start": 54,
"end": 56
},
"arguments": [
{
"role": "Treatment",
"text": "HDARAC",
"start": 57,
"end": 63
},
{
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Agranulocytosis associated with ticlopidine: a possible benefit with filgastim. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "associated",
"start": 16,
"end": 26
},
"arguments": [
{
"role": "Treatment",
"text": "ticlopidine",
"start": 32,
"end": 43
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Since SS is a clinical diagnosis, heightened clinician awareness of the possibility of SS among patients receiving SSRI or mirtazapine in combination with opioids may lead to earlier detection and avoidance of potentially lethal consequences. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "lead to",
"start": 167,
"end": 174
},
"arguments": [
{
"role": "Effect",
"text": "potentially lethal consequences",
"start": 210,
"end": 24... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
The mechanism by which sunitinib induces gynaecomastia is thought to be associated with an unknown direct action on breast hormonal receptors. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "induces",
"start": 33,
"end": 40
},
"arguments": [
{
"role": "Treatment",
"text": "sunitinib",
"start": 23,
"end": 32
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Some patients develop hypersensitivity rash in response to HCQ. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "develop",
"start": 14,
"end": 21
},
"arguments": [
{
"role": "Subject",
"text": "Some patients",
"start": 0,
"end": 13
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
To report a case of serotonin toxicity, presenting in the postoperative period, caused by an interaction between paroxetine (a selective serotonin reuptake inhibitor, SSRI) and fentanyl (a phenylpiperidine opioid). | {
"events": {
"adverse event": [
{
"trigger": {
"text": "caused",
"start": 80,
"end": 86
},
"arguments": [
{
"role": "Effect",
"text": "serotonin toxicity",
"start": 20,
"end": 38
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
However, to our knowledge, in newborns there have been no reported cases to date of thrombocytosis induced by enoxaparin. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "induced",
"start": 99,
"end": 106
},
"arguments": [
{
"role": "Subject",
"text": "newborns",
"start": 30,
"end": 38
},
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
The case presented here documents adverse cardiac effects in a 28-year-old man who intentionally ingested 24 mg of risperidone--4 times the recommended dose. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "ingested",
"start": 97,
"end": 105
},
"arguments": [
{
"role": "Effect",
"text": "adverse cardiac effects",
"start": 34,
"end": 57
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
Anaphylaxis to cisplatin following nine previous uncomplicated cycles. | {
"events": {
"adverse event": [
{
"trigger": {
"text": "to",
"start": 12,
"end": 14
},
"arguments": [
{
"role": "Effect",
"text": "Anaphylaxis",
"start": 0,
"end": 11
},
{
... | {
"events": [
{
"label": "adverse event",
"description": "The use of a drug or combination of drugs causes a harmful effect on the human patient.",
"description_source": "official",
"roles": [
{
"label": "Subject",
"description": "The patients involved in the me... |
End of preview. Expand in Data Studio
PHEE
PHEE (event extraction), rebuilt for MNEB from the original release with character-level offsets.
Source: https://github.com/ZhaoyueSun/PHEE (data/json)
| config | split | records |
|---|---|---|
| default | train | 2898 |
| default | validation | 961 |
| default | test | 968 |
Labels
events: adverse event, potential therapeutic event
Format
Each record has input (the text), output (gold annotations grouped by label) and schema (the label set with descriptions). Offsets are character offsets into input, half-open [start, end).
"output": {
"entities": {"<label>": [{"text", "start", "end"}]},
"relations": {"<label>": [{"head": {"text", "start", "end"},
"tail": {"text", "start", "end"}}]},
"events": {"<label>": [{"trigger": {"text", "start", "end"},
"arguments": [{"role", "text", "start", "end"}]}]}
}
Each schema item has a description and a description_source: official when adapted from the dataset's paper or guideline, mneb when written for MNEB. Relation datasets also give setting (end_to_end or gold_entity) and negative_label; relation items give symmetric. Event items list the roles valid for that event type.
Within a record, identical annotations are kept once and outer whitespace is trimmed from spans; source annotations are otherwise kept as annotated.
Notes
- All events of a sentence are kept; the previous version kept only the first.
- Sub-arguments are flattened to
Main.Subroles; Severity, Speculated, Negated and Combination annotations are not included. - Descriptions are adapted from Appendix A of the paper.
Build
Built by scripts/datasets/phee.py in the MNEB repository.
Citation
Sun et al. (2022), PHEE: A Dataset for Pharmacovigilance Event Extraction from Text. EMNLP.
License: mit
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