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TCGA-BP-5195.25c0b433-5557-4165-922e-2c1eac9c26f0
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Date of Recelpt: Clinical Diagnosis & History: Incidental 3 cm left upper pole renal mass. Specimens Submitted: 1: Kidney, Left Upper Pole; Partial Nephrectomy. DIAGNOSIS: 1. Kidney, Left Upper Pole; Partial Nephrectomy: Tumor Type: Renal cell carcinoma - Conventional (clear cell) type. Fuhrman Nuclear Grade: Nuclear grade II/IV. Tumor Size: Greatest diameter is 2.4 cm. Local Invasion (for renal cortical types): Not Identified. Renal Vein Invasion: Not identified. Surgical Margins: Free of tumor. Non-Neoplastic Kidney: shows focal chronic inflammation and focal superficial glomerulosclerosis. Adrenal Gland: Not identified. Lymph Nodes: Not identified. Staging for renal cell carcinoma/oncocytoma: pT1 Tumor <= 7.0 cm in greatest dimension limited to the kidney. JATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT IHAVE. REVIEWED AND APPROVED THIS REPORT. Gross Description: 1). The specimen Is received fresh for frozen section consultation, labeled "left upper pole renal tumor stitch marks deep margin". It consists of a 6.6 X 3.7 x 2.9 cm wedge shaped portion of kidney with a suture marking the deep margin and attached 12.2 x 8,5 x. 2.7 cm of perirenal. Also received in the same container Is a separate 11.6 x 8.4 x 4.6 cm aggregate of unremarkable. fibroadipose tissue. The margin is inked black and the specimen is serially sectioned to reveal a well-circumscribed cortically. based yellow focally hemorrhagic 2.4 x 2.0 x 1.9 cm tumor. The tumor appears grossly confined to the renal parenchyma, no. extension into perirenal fat is identified. The clearance from the resection margin is 1.1 cm. A representative section of the. nearest margin is submilted for frozen section diagnosis. Representatively submitted. A photograph Is taken. Portions of the. tumor are submitted for TPS. Summary of sections: FSC - frozen section control. T tumor. M margin. RS - representative sections. Summary of Sections: Part 1: Kidney, Left Upper Pole; Partial Nephrectomy. Block. Sect. Site. PCs. 1. fsc. 1. 2. m. 2. 1. rs. 1. 2. t. 2. Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the. tissue sample examined at the time of the intraoperative. consultation. 1). FROZEN SECTION DIAGNOSIS: LEFT UPPER POLE RENAL TUMOR. RENAL CORTICAL NEOPLASM. WITH BENIGN MARGIN. PERMANENT DIAGNOSIS: SAME.
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TCGA-D7-8573.b7306a47-697d-4ed3-bbe1-81d49674a8f8
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Material: 1) Material: stomach, Method of collection: Lesion resection. Histopathological diagnosis: (including test No. G-3155/12): Adenocarcinoma tubuläre ventriculi. G3, pT3, pNO. Tubular adenocarcinoma of the. stomach. Typus intestinalis sec Lauren. Intestinal type Lauren. Macroscopic description: Adenocarcinoma tubuläre G3. Cancerous proliferation reaches the periteneal surface of the stomach. Surgical incision lines free of. neoplastic lesions. Mucosa outside the tumour showing features of chronic inflammation with focal intestinal metaplasia. Adjacent part of the omentum free of cancerous lesions. 3 - (lesser curvature): Lymphonodulitis reactivaNo VIII. 4 - (greater curvature) :Lymphonodulitis reactiva No VII. 5 - (peripyloric): Lymphonodulitis reactivaNo IV. Microscopic description: The specimen containing the stomach, after being incised along the greater curvature sized 18.5 X 16cm with the. omentum sized 30 X 16cm. Cauliflower-shaped tumour on the greater curvature sized 5.5 X 4.5 X 2.4 cm. Distance from. the proximal end: 8.0cm, from distal end: 5.0cm.
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TCGA-EI-7004.13591eed-30e5-47a3-91be-7a370663d2d4
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page 1 / 1. copy No. 3. Examination: Histopathological examination. Cost of diagnostic procedure. Material: 1. Total organ resection - rectum and sigmoid colon. Material collected. Expected time of examination: Clinical diagnosis: Cancer of the rectosigmoid junction. Macroscopic description: A 26 cm length of the large intestine with a piece of mesentery and periintestinal tissue sized 20 X 11.7 cm. A tumour. sized 1.6 X 1 X 1.8 cm found in the mesentery. A flat tumour sized 7.8 X 2 X 0.6 cm found in the mesentery infiltrating. the whole thickness of the intestine. The lesion surrounds 100% of the intestine circumference and narrows its. lumen, is located 14.5 cm away from one of the excision lines and 4.3 cm from the other one. Minimum side margin. is 3 cm. Neighbouring lymph nodes are metastatic in gross appearance forming concretions. Microscopic description: Adenocarcinoma mucocellulare et mucinosum (G3). Infiltratio carcinomatosa profunda tunicae. muscularis priopriae et serosae flexure coli (sigmoideo - rectalis) et telae adiposae mesenterii et. mesorecti. Intestine ends clear of neoplastic lesions. Metastases carcinomatosae in lymphonodis (NO XXX/XXX). Infiltratio carcinomatosa capsulae lymphonodorum et telae adiposae perinodalis. The number of lymph nodes difficult to assess due to the concretions. Histopathology diagnosis: Adenocarcinoma mucocellulare et mucinosum flexure sigmoideo - rectalis. Mucocellular and mucinous. adenocarcinoma of sigmoid rectal junction. Metastases carcinomatosae in lymphonodis. Cancer metastases in the lymph nodes (No XXX/XXX). (G3, Dukes C, Atler - Coller C2, pT4, pN2b).
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TCGA-EB-A82B.23E186C6-739C-4EF1-8788-79AA89C6E87A
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Patient ID: Gross Description: A mass is located in right feet skin, with 5x4x2cm, firm, brown, black-gray surface. Microscopic Description: Epidermis is necrotic, ulcerated. Tumor is composed of spindle or oval tumor. cells with quitely scant cytoplasm. Sometime the cytoplasm contains finely divided melanin pigment. granulaes. Tumor cells have a quite low nucleo-cytoplasmic ratio. Nucleus varies in shape and size with. large esinophilic nucleoli. Mitotic figures are present. Tumor cells invade into fat tissue. Diagnosis Details: Malignant melanoma. Breslow tumor thickness: 20mm. Comments: Formatted Path Reports: SKIN TISSUE CHECKLIST. Specimen type: Surgical resection. Tumor site: Skin, foot. Tumor size: 5x4x2cm. Tumor features: Ulcerated, Pigmented, Necrotic. Satellite nodules: Not specified. Histologic type: Malignant melanoma. Histologic grade: Poorly differentiated. Lymph nodes: 2/9 positive for metastasis (Right inguinal and pelvic lymph node 2/9). Lymphatic invasion: Not specified. Venous invasion: Not specified. Margins: Not specified. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Right foot, Breslow tumor thickness: 20mm. Comments: None.
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TCGA-A6-3808.e1505f65-72ef-438d-a5e1-93ed8bf6635d
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SPECIMEN. Right colon. CLINICAL NOTES. PRE-OP DIAGNOSIS: Carcinoma right colon. GROSS DESCRIPTION. Received fresh for tissue procurement labeled "right. colon". is a previously unopened 15 cm. segment of proximal right. colon with attached 15 cm. distal ileum surfaced by smooth to. scabrous tan pink serosa with a copious amount of attached. mesocolon. and mesentery. No appendix is present. The proximal and distal. margins measure 3.2 and 5.2 cm. in circumference respectively. On. opening there is a well circumscribed, 4.4 x 4.0 cm. rubbery tan. white-red tumor mass within the cecal pouch, 1 cm. distal to the. ileocecal valve. A portion of tumor and a portion of normal are. submitted for tissue procurement as requested. On sectioning, the. tumor has a maximal thickness of 1.1 cm., grossly extending through. the muscularis to within 0.1 cm. of the inked free serosal surface. The ileal mucosa and remaining colonic mucosa is unremarkable. glistening tan pink with irregular folds and the walls average 0.5. cm. in thickness. Multiple soft pale tan to tan pink tissues in. keeping with lymph nodes measuring up to 1.4 cm. in greatest. dimension are recovered from the attached mesocolon and mesentery. Representative sections are submitted in 13 blocks as labeled. RS13. BLOCK SUMMARY: 1 - Proximal and distal margins; 2-4 - tumor full. thickness to inked free radial serosal surface; 5 - tumor to. normal;. 6 - ileum; 7 - ICB; 8 - colon; 9 and 10 - eight whole lymph nodes. per cassette; 11 - six whole lymph nodes; 12 and 13 - one bisected. lymph node per cassette. MICROSCOPIC DESCRIPTION. Histologic type: Adenocarcinoma with mucinous differentiation. Histologic grade Moderately-differentiated. Primary tumor (pT) : Tumor invades through the muscularis propria. into the pericolonic fat (pT3). Proximal margin: Negative. Distal margin: Negative. Circumferential (radial) margin: Negative. Vascular invasion: Negative. Regional lymph nodes (pN) : 24 lymph nodes are negative for. metastatic carcinoma (pN0). Non-lymph node pericolonic tumor: Absent. Distant metastasis (pM) : Cannot be assessed (pMx) . DIAGNOSIS. Colon, right and terminal ileum, resection: Invasive moderately-differentiated colonic adenocarcinoma with. mucinous differentiation extending through the wall of the colon. into the pericolonic fat. The proximal, distal and radial margins of resection are free of. tumor. Twenty four mesenteric lymph nodes are negative for. metastatic carcinoma (0/24).
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TCGA-29-1761.63defa27-e729-4514-bdd2-d887c4100854
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CLINICAL HISTORY: Pelvic organ prolapse, bilateral adnexal masses. GROSS EXAMINATION: A. "Omentum", received fresh. A 25 x 17 x 7 cm aggregate of firm, matted. adipose and fibrous tissue with scabrous yellow tan cut surfaces. Representative sections are submitted as Blocks A1-A2. B. "Right tube and ovary", received fresh. A 59.4 gram, 8.5 x 5.2 x 3.5 cm. friable tan-pink mass with an identifiable 6.5 cm length of tube and focally. adherent fat. One nodule is adjacent to the fimbriated end of the tube,. Sectioning reveals predominantly compact yellow gray cut surfaces and. peripheral cyst like formation lined by granular friable surfaces (B3). Representative sections to include fallopian tubes are submitted as Blocks. B1-B3. c. "Left tube and ovary and uterus", received fresh. A 62.2 gram portion of. tissue composed of 5.4 x 4.5 x 3.5 cm uterine body with attached 6.5 cm length. of fallopian tube and adjacent 3.5 x 2.5 x 1.0 cm ovary. No cervix is. identified. The serosa is markedly nodule with a friable tan-gray mass. extending onto the fallopian tube and ovarian serosa. The endometrium is. granular tan-pink and less than 0.1 cm in thickness. The myometrium is 1.5 cm. in thickness and contains a 1.9 cm circumscribed firm yellow intramural nodule. and a focally calcified 1.5 cm diameter subserosal nodule. Sectioning the. ovary reveals a compact whorled cut surface adjacent to the friable external. nodules. BLOCK SUMMARY: C1- posterior endomyometrium toward lower uterine segment. C2- anterior lower uterine segment. C3- anterior endomyometrium with intramural fibroids and serosal nodules. C4- left fallopian tube. C5- left ovary. D. "Sigmoid colon", received fresh. An 8 cm segment of unoriented bowel with. two stapled ends and multiple adherent friable red-tan nodules and matted. adipose. The bowel segment is opened to reveal a tan velvety mucosa with no. lesions identified. Sectioning reveals the friable external mass to encase the. segment of bowel. Representative sections are submitted as Blocks D1-D2. DIAGNOSIS: A. "OMENTUM" (BIOPSY) : METASTATIC ADENOCARCINOMA INVOLVING OMENTAL TISSUE. B. "RIGHT TUBE AND OVARY" (SALPINGO-OOPHORECTOMY) : 1. ORLY-DIFFERENTIATED SEROUS ADENOCARCINOMA OF OVARY. - TUMOR SIZE 8. .CM;. - TUMOR INVOLVES OVARIAN SURFACE. TUMOR IMPLANTS EXTENSIVELY INVOLVE FALLOPIAN TUBE. C. "LEFT TUBE AND OVARY AND UTERUS" (HYSTERECTOMY AND SALPINGO-OOPHORECTOMY) : 1. POORLY-DIFFERENTIATED SEROUS ADENOCARCINOMA INVOLVING OVARIAN HILUM. AND UTERINE SEROSA. 2. ENDOMETRIUM WITH CYSTIC ATROPHY. 3. MYOMETRIUM WITH LEIOMYOMA (1.3 CM). 4. NO CERVIX IDENTIFIED. 5. FALLOPIAN TUBE, NEGATIVE FOR CARCINOMA. D. "SIGMOID COLON" (SEGMENTAL RESECTION) : SEGMENT OF COLON (8 CM), WITH SEROSAL IMPLANT OF METASTATIC. ADENOCARCINOMA. I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es).
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TCGA-24-1616.d8c764d9-0fe8-488e-8aa1-da73a8c10b01
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Address: : Physician (s) : Other Related Clinical Data: DIAGNOSIS: UTERUS, TOTAL ABDOMINAL HYSTERECTOMY. - METASTATIC ADENOCARCINOMA INVOLVING SEROSA AND SUB ENDOMETRIAL MYOMETRIUM. - ENDOMETRIAL POLYPS. - INTRAMURAL LEIOMYOMA. - CERVIX WITH NO HISTOPATHOLOGIC ABNORMALITY. OVARY, LEFT, SALPINGO-OOPHORECTOMY. PAPILLARY SEROUS ADENOCARCINOMA, MODERATELY DIFFERENTIATED (FIGO GRADE II/III),. INVOLVING PERI-OVARIAN SOFT TISSUE. FALLOPIAN TUBE, LEFT, SALPINGO-OOPHORECTOMY. - METASTATIC ADENOCARCINOMA, INVOLVING TUBAL EPITHELIUM AND PARATUBAL SOFT TISSUE. OVARY, RIGHT, SALPINGO-OOPHORECTOMY. - METASTATIC ADENOCARCINOMA, INVOLVING OVARIAN PARENCHYMA AND PERI-OVARIAN SOFT TISSUE. FALLOPIAN TUBE, RIGHT, SALPINGO-OOPHORECTOMY. - METASTATIC ADENOCARCINOMA, INVOLVING PERITUBAL SOFT TISSUE. SOFT TISSUE, "LARGE BOWEL TUMOR," EXCISION. - METASTATIC ADENOCARCINOMA. OMENTUM, EXCISION. - METASTATIC ADENOCARCINOMA. - ONE LYMPH NODE WITH NO EVIDENCE OF MALIGNANCY. By this signature, I attest that the above diagnosis is based upon my. personal. examination of the slides (and/or other material indicated in the diagnosis). is smooth, but there is a solid area with exophytic, tan, polypoid tumor. Attached to the. external surface of the mass is soft tissue measuring 3.0 x 1.5 x 1.5 cm, but cut surfaces. do not show any identifiable fallopian tube. Also present in the container is a cassette. labeled "FS2" that holds a piece of tumor measuring 2.0 x 1.5 x 0.3 cm. Labeled B1 - FS2. remnant; B2 and B3 - tumor present on inked ovarian surface; B4 to B5 - tumor; B6 - necrotic. tumor; B7 - tumor nodule within cyst; B8 to B9 - attached soft tissue (possible fallopian. tube) B10-B14: additional tumor. The third container is labeled "#3, right adnexa" and contains a single piece of tan,. friable, partially necrotic tumor measuring 8.5 x 7.3 x 4.0 cm. One surface is smooth and. white, suggesting the possibility that someone opened the specimen prior to receipt in. pathology. A portion of fallopian tube measuring 2.6 cm in length and 0.5 cm in diameter. includes fimbria and is adhesed to the outer surface of the mass. Although adhesed to the. mass, the fallopian tube is mobile and does not appear to be involved by the tumor. Labeled. C1 to C4 - tumor; C5 - fallopian tube. C6-C10 : additional tumor. The fourth container is labeled "#4, omentum" and contains two pieces of lymphoid tissue. together measuring 16 x 14 x 2 cm. Approximately one-fourth of the tissue is involved by. a firm white tumor, the largest single implant measuring 9.5 cm in maximum dimension. The. specimen is sectioned at 0.3-0.4 cm intervals and every tumor nodule is sampled at least. once, All the tumor implants have a similar gross appearance. Labeled D1 to D13. Synopsis-. SYNOPTIC.REPORTING FORM FOR MALIGNANT OVARIAN NEOPLASMS. 1. A neoplasm is PRESENT. 2. The HISTOLOGIC DIAGNOSIS is: Serous adenocarcinoma in ovaries. : Poorly-differentiated carcinoma in omentum. 3. The LOCATION (S) OF THE PRIMARY TUMOR (S) is/are: :- Right and left ovary (synchronous primary tumors). 4. The FIGO GRADE of the tumor is: Not applicable. 5. The NUCLEAR (BRODERS') GRADE of the tumor is: G3 Poorly-differentiated). 6. Tumor IS identified on both ovarian surfaces. 7. Tumor DOES NOT invade the mesovarium,. 8. Tumor DOES NOT invade the adjacent fallopian tube, but is present in the paratubal soft. tissue. 9. Tumor invasion of non-adnexal pelvic soft tissue CANNOT BE EVALUATED. 10. Tumor involvement of the non-adnexal pelvic peritoneum CANNOT BE EVALUATED. 11. Metastatic involvement of the EXTRAPELVIC PERITONEUM is PRESENT (omentum). 12. Metastatic involvement of the omentum is PRESENT. 13. The maximum dimension of tumor implants outside the true pelvis is 9.5 cm. 14. Metastatic involvement of the uterine serosa CANNOT BE EVALUATED. 15. Metastatic involvement of the endometrium CANNOT BE EVALUATED. 16. Regional lymph node metastases are present. 17. The total number of regional lymph nodes examined is 1. 18. The total number of metastatically-involved regional lymph nodes is 1. 19. DETAILED STAGING INFORMATION: Based on the above information, the PRIMARY TUMOR is classified as: TNM Scheme. FIGO Scheme. Definition. T3c. IIIC. Peritoneal metastasis beyond. true pelvis measuring > 2 cm in greatest dimension or regional lymph node metastasis. diffusely infiltrate/involved by numerous tan-grey, separate or confluent nodular lesions. with areas of necrosis and hemorrhage. Synopsis. SYNOPTIC REPORTING FORM FOR MALIGNANT OVARIAN NEOPLASMS. 1. A neoplasm is PRESENT. 2. The HISTOLOGIC DIAGNOSIS is: Serous adenocarcinoma. 3. The LOCATION (S) OF THE PRIMARY TUMOR (S) is/are: Left and right ovary. 4. The FIGO GRADE of the tumor is: II. 5. The NUCLEAR (BRODERS') GRADE of the tumor is: G3. 6. Tumor IS identified on the ovarian surface (s) . 7. Tumor DOES invade the mesovarium. 8. Tumor DOES invade the adjacent fallopian tube. 9. Tumor DOES invade the pelvic soft tissue. 10. Tumor involvement of the pelvic peritoneum CANNOT BE EVALUATED. 11. Metastatic involvement of the EXTRAPELVIC peritoneum CANNOT BE EVALUATED. 12. Metastatic involvement of the omentum is PRESENT. 13. The maximum dimension of tumor implants outside the true pelvis is 10 cm. 14. Metastatic involvement of the uterine serosa is PRESENT. 15. Metastatic involvement of the endometrium is PRESENT. 16. Regional lymph node metastases CANNOT BE EVALUATED. 17. The total number of regional lymph nodes examined is 0. 18. The total number of metastatically-involved regional lymph nodes CANNOT BE EVALUATED. 19. DETAILED STAGING INFORMATION: Based on the above information, the PRIMARY TUMOR is. classified as: TNM Scheme. FIGO Scheme. Definition. T3c. IIIC. Macroscopic peritoneal. metastasis beyond true pelvis measuring > 2 cm in. greatest dimension,. THE REGIONAL LYMPH NODES are classified as: NX (Nodal status cannot be assessed). THE STATUS OF DISTANT TUMOR SITES is classified as: MX (Status cannot be assessed). 20. The FINAL AJCC/UICC/FIGO STAGE IS: AJCC/UICC/FIGO. X. Insufficient data to assign stage. The pathologic stage assigned here should be regarded as provisional, and may change after. integration of clinical data not provided with this specimen.
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TCGA-IN-A6RO.C0E5F045-3F12-45CF-A6A4-034D99F2A719
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FINAL DIAGNOSIS: PART 1: ESOPHAGUS, ESOPHAGECTOMY -. A. ADENOCARCINOMA, MODERATELY DIFFERENTIATED, SCM, INVASIVE INTO THE SUBMUCOSA (pT1b). B. NEGATIVE FOR ANGIOLYMPHATIC AND PERINEURAL INVASION. C. SURGICAL RESECTION MARGINS (PROXIMAL ESOPHAGUS, DISTAL STOMACH AND ADVENTITIAL MARGIN). ARE NEGATIVE FOR NEOPLASTIC INVOLVEMENT. D. THE TUMOR COMES WITHIN 0.2CM OF THE RADIAL/ADVENTITIAL SURGICAL RESECTION MARGIN. E. 1.6CM DISTALLY FROM THE MAIN TUMOR IS A 0.9CM FOCUS OF HIGH GRADE DYSPLASIA. F. BACKGROUND GASTROESOPHAGEAL MUCOSA WITH BARRETT'S MUCOSA. G. THERE IS NO EVIDENCE OF MALIGNANCY IN NINE LYMPH NODES (0/9). H. AJCC STAGING: pT1b NO. PART 2: LYMPH NODE, SUBCARINAL NEAR LEFT MAIN BRONCHUS, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 3: LYMPH NODE, SUBCARINAL NEAR RIGHT MAIN BRONCHUS, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 4: LYMPH NODE, SUBCARINAL NEAR PERICARDIUM, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 5: LYMPH NODE, SUBCARINAL NEAR THORACIC DUCT, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 6: LYMPH NODE, PARAESOPHAGEAL NEAR LEFT VEIN, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 7: LYMPH NODE, PARAESOPHAGEAL NEAR RIGHT CRUS, EXCISION -. A. FIBROADIPOSE TISSUE, NO LYMPH NODES IDENTIFIED. B. THERE IS NO EVIDENCE OF MALIGNANCY. PART 8: LYMPH NODE, NEAR VAGUS, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 9: LYMPH NODE, SUBCARINAL NEAR ATRIUM, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 10: LYMPH NODE, LESSER CURVE, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 11: LYMPH NODE, NEAR LEFT GASTRIC ARTERY, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 12: LYMPH NODE, GASTRIC FAT, EXCISION -. A. SKELETAL MUSCLE AND FIBROADIPOSE TISSUE, NO LYMPH NODE IDENTIFIED. B. THERE IS NO EVIDENCE OF MALIGNANCY. PART 13: LYMPH NODE, NEAR AZYGOUS, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 14: LYMPH NODE, FAT PAD, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1). PART 15: LYMPH NODE, PERIESOPHAGEAL AND FAT PAD NEAR DIAPHRAGM, EXCISION -. THERE IS NO EVIDENCE OF MALIGNANCY IN TWO LYMPH NODES (0/2). PART 16: ANASTOMOTIC RINGS, EXCISION -. A. RING OF STOMACH WITH OXYNTIC MUCOSA. B. RING OF ESOPHAGUS WITH SKELETAL MUSCLE. C. THERE IS NO EVIDENCE OF MALIGNANCY. PART 17: FINAL GASTRIC MARGIN, EXCISION -. A. STOMACH WITH OXYNTIC MUCOSA. B. THERE IS NO EVIDENCE OF MALIGNANCY. COMMENT: Part one. Esophagus, esophagectomy: The 5.0cm present at the gastroesophageal junction is similar to previous blopsy. by report as siides are not available for review. The tumor. comes to within 2mm of the adventitial surgical resection margin. There is a separate 0.9cm lesion with high grade. dysplasia located 1.6 cm distally to the main 5cm adenocarcinoma. No anglolymphatic invasion Is seen using double. immunohistochemical stain D240/AE1/3. CASE SYNOPSIS: SYNOPTIC DATA - PRIMARY ESOPHAGEAL TUMORS. MACROSCOPIC. SPECIMEN TYPE: Esophagogastrectomy. TUMOR SITE: Esophagogastric junction (EGJ) region (tumor involves EGJ and epicenter within 5cm. of EGJ). TUMOR SIZE: Greatest dimension: 5 cm. Additional dimensions: 2.3 cm. MICROSCOPIC. HISTOLOGIC TYPE: Adenocarcinoma. HISTOLOGIC GRADE: G2. PATHOLOGIC STAGING (PTNM). pT1b. pNO. Number of lymph nodes examined: 22. Number of lymph nodes Involved: 0. pM Not applicable. PRIOR TREATMENT: No prior treatment. MARGINS. Proximal margin uninvolved by invasive carcinoma. Proximal margin uninvolved by dysplasia. Proximal margin uninvolved by intestinal metaplasia. Distal margin uninvolved by invasive carcinoma. Distal margin uninvolved by dysplasia. Distal margin uninvolved by intestinal metaplasia. Circumferential (adventitial) margin uninvolved by invasive carcinoma. Distance of invasive carcinoma from closest margin: 4 mm. Specify margin: adventitial margin. ANGIOLYMPHATIC INVASION: Absent. ADDITIONAL PATHOLOGIC FINDINGS: Intestinal metaplasia (Barrett's esophagus). High grade dysplasia.
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TCGA-44-8119.c40ea4c8-8cbe-4a44-96d4-ae524a916449
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Final Surgical Pathology Report. Procedure: Diagnosis. A. Lung, right upper lobe with adjacent chest wall, en bloc resection: Invasive poorly differentiated adenocarcinoma extending into the soft. tissues of the chest wall. The radial, vascular and bronchial margins of resection are free of. tumor. Apical emphysematous changes. Benign pleural plaque. 4 hilar lymph nodes negative for metastatic carcinoma (0/4) . Nonnecrotizing granulomatous lymphadenitis; special stains for. acid-fast and fungal organisms. are both negative. B. Rib, third, medial margin: Negative for malignancy. C. Lymph nodes, part of 4R, resection: Nonnecrotizing granulomatous lymphadenitis; negative for malignancy. D. Lymph node, level X, resection: Nonnecrotizing granulomatous lymphadenitis; negative for malignancy. E. Lymph node, level XI, resection: Nonnecrotizing granulomatous lymphadenitis; negative for malignancy. F. Rib, fourth, medial margin: Negative for malignancy. G. Lymph node, 2R, resection: Nonnecrotizing granulomatous lymphadenitis; negative for malignancy. H. Lymph node, level IX, resection: Nonnecrotizing granulomatous lymphadenitis; negative for malignancy. I. Lymph node, level VII, resection: Nonnecrotizing granulomatous lymphadenitis; negative for malignancy. Microscopic Description: Sections of the lung tumor reveals a poorly differentiated. non-small cell carcinoma. The tumor does not have any well formed. glands or areas of keratinization. Immunohistochemistry reveals. positive staining for both CEA and TTF-1 with a negative result for CK. 5/6 and P63. This pattern of staining is indicative of a. adenocarcinoma. Results of the resection as summarized in the. following template -. Histologic type: Adenocarcinoma. Histologic grade: Poorly differentiated. Primary tumor (pT) : Tumor has extended from the lung through the chest. wall into the soft tissue adjacent to ribs (pT3) . Margins of resection: Negative. Direct extension of tumor: Direct extension into the chest wall is. present. Venous (large vessel) invasion: Positive. Arterial (large vessel) invasion: Negative. Lymphatic (small vessel) invasion: Negative. Regional lymph nodes (pN) : All of the hilar lymph nodes and sampled. mediastinal lymph nodes are negative for metastatic carcinoma (pNO). Distant metastasis (pM) : pMx. Other findings: All the lymph nodes containing non-necrotizing. granulomatous lymphadenitis. Special stains for acid-fast and fungal. organisms are both negative. Specimen. A. Right upper lobe with chest wall. B. 3rd rib margin medial. C. Part of 4R. D. level X nodes. E. Level XI. F. 4th rib medial margin. G. 2R. H. Level 9. I. Level 7. Clinical Information. Lung mass. Intraoperative Consultation. lobe - Poorly differentiated non-small carcinoma. Gross Description. A. Received fresh labeled "right upper lobe with chest wall" is a 308. g, 18.0 X 11.0 X 4.5 cm lobectomy specimen with attached 1.5 cm in. length, 1.5 X 1.5 cm in diameter bronchial stump. Several soft. gray-black perihilar lymph nodes measuring up to 2.4 cm are recovered. A 19 cm staple line traverses the pleura (subsequently removed) . Three. ribs spanning an area of 9.8 X 5.8 cm are present along one aspect. The pleura is smooth to scaberous tan red with a subjacent induration. adjacent to the adherent ribs. The pleura overlying the induration is. inked orange. The external surface of the ribs is inked blue. On. sectioning, there is a 5.5 X 4.7 X 3.5 cm rubbery tan-white to. gray-black tumor mass subjacent to the adherent ribs. The tumor. appears to extend into the intercostal muscles and to within 0.1 cm of. the inked pleural surface. A portion of tumor and a portion of normal. parenchyma are submitted for tissue procurement as requested. The. remaining parenchyma is spongy form tan-red without additional mass. lesion. Diffuse crepitance is present in the vicinity of the tumor. mass. In addition, a rubbery 1.4 cm greatest imension tan-white. nodule is noted within the adherent pleura. Summary: 1 - bronchial margin, 2 - vascular gins, 3 and 4 - tumor. to. inked pleural surface, 5 and 6 - tumor to intercostal muscle, 7 and 8 -. random tumor, 9 - random parenchyma, 10 - bisected pleural nodule,. early 11 - 4 hilar lymph nodes, 12 and 13 - bisected largest hilar. lymph node, 14 through 18 - tumor to rib following fixation and. alcification. B. Received fresh labeled "3rd rib margin medial" is an irregular, 1.9. X 1.4 X 1.0 cm portion of focally fragmented hard tan-white bone with a. scant amount of associated soft tissue. The specimen is inked,. sectioned, and entirely submitted in one block following fixation and. decalcification. C. Received fresh labeled "part of 4R" is slightly fragmented 0.6 cm. greatest dimension soft tan-gray tissue. D. Received fresh labeled "level X nodes" are 4 ft tan-gray tissues. ranging from 0.4-0.8 cm in greatest dimension. E. Received fresh labeled "level XI" is a 0.7 X 0.5 X 0.4 cm soft. tan-gray tissue which is bisected and entirely submitted in one block. F. Received fresh labeled "4th rib medial margin" is an irregular,. slightly fragmented, 1.5 X 1.3 X 0.5 cm hard tan-white portion of bone. The specimen is inked, sectioned, and entirely submitted in one block. following fixation and decalcification. G. Received fresh labeled "2R" are 3 so an-gray tissues ranging. from 0.3-1.2 cm in greatest dimension. Summary: 1 - 2 tissues, 2 - bisected lary. tissue. H. Received fresh labeled "level IX" is an irregular 1.3 X 0.3 X 0.2. cm soft tan-gray tissue which is submitted in toto in one block. I. Received fresh labeled "level VII" are 2 soft tan-gray tissues. averaging 1. cm in greatest dimension. The specimens are bisected and. irely submitted independently in 2 blocks.
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TCGA-KK-A6E8.3716A52E-E0B7-4FE0-AC2B-07F2F3A0D6AD
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MODIFIED REPORT - REVIEW ADDENDUM SECTION. DIAGNOSIS. (A) PERIPROSTATIC LYMPH NODE: Adipose tissue, no tumor present. No lymph nodes present. (B) ANTERIOR APEX: Prostatic tissue, no tumor present. Normal glands present focally at the inked surface. (C) PROSTATE AND SEMINAL VESICLES: Supplemental report to follow. (D) LEFT PELVIC LYMPH NODES: Seven lymph nodes, no tumor present. (E) RIGHT PELVIC LYMPH NODES: Seven lymph nodes, no tumor present. Entire report and diagnosis completed by. GROSS DESCRIPTION. (A). PERIPROSTATIC. LYMPH NODE - Received is a portion of yellow-tan fibrofatty adipose tissue that is focally hemorrhagic. measuring 2.5 X 2.0 x 0.6 cm. Tissue is dissected revealing no definite lymph node tissue. Tissue is submitted entirely. in. cassettes A1-A4. (B). ANTERIOR APEX - A fragment of tan grey tissue (0.5 x 0.4 x 0.2 cm). The surface previously inked is reinked. Submitted in. toto for frozen section. FS/DX: PROSTATIC GLANDS AT THE MARGIN. TUMOR NOT IDENTIFIED. (C) PROSTATE AND SEMINAL VESICLES - Supplemental report to follow. (D). LEFT PELVIC LYMPH NODE - Received is a portion of yellow-tan fibrofatty adipose tissue measuring 5.8 x 3.8 x 1.0 cm. Tissue is dissected revealing seven possible lymph nodes that range from 0.5 x 0.4 x 0.3 cm up to 2.0 x 0.8 x 0.5 cm. Possible. lymph nodes are submitted in cassettes D1-D7. SECTION CODE: D1, three possible lymph nodes; D2, single possible lymph node, bisected; D3, single possible lymph. node, trisected; D4, single possible lymph node, bisected; D5-D7, single possible lymph node, sectioned. (E) RIGHT PELVIC LYMPH NODE - Received is a portion of yellow-tan fibrofatty adipose tissue measuring 6.5 x 3.5 x 0.8 cm. Tissue is dissected revealing seven possible lymph nodes that range from 0.3 x 0.3 X 0.2 cm up to 1.2 x 0.5 X 0.4 cm. Possible. lymph nodes are submitted in cassettes E1-E3. SECTION CODE: E1, four possible lymph nodes; E2, two possible lymph nodes; E3, single possible lymph node. sectioned. CLINICAL HISTORY. Prostate cancer. CONSULTANT(S). SNOMED CODES. Page: 2. "Some tests reported here may have been developed and performance characteristics determined by. These tests have not been. specifically cleared or approved by the U.S. Food and Drug Administration.". Released by: Start of ADDENDUM. Page: 3. ADDENDUM. This modified report is being issued to provide additional information/results. Addendum completed by. DIAGNOSIS. (C) PROSTATE AND SEMINAL VESICLES: PROSTATIC ADENOCARCINOMA, GLEASON SCORE 9 (4 + 5), (SEE COMMENT). FOCAL EXTENSION OF TUMOR TO THE LEFT APICAL MARGIN OF RESECTION CANNOT BE EXCLUDED. No extraprostatic extension present. PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN), HIGH GRADE. Right and left seminal vesicles, no tumor present. Segments of right and left vasa deferentia, no tumor present. Entire report and diagnosis completed by. COMMENT. The prostate gland contains a single focus of prostatic adenocarcinoma. The tumor is located in the transition zone and occupies. practically the entire anterior half of the prostate. The tumor focus measures 3.5 x 1.5 cm in the largest cross-sectional dimension,. and it is present in the two cross sections of the prostate, extensively in the apex and focally in the base region. Focal extension of. tumor (less than 1.0 mm) to the left apical margin cannot be excluded. GROSS DESCRIPTION. (C) PROSTATE AND SEMINAL VESICLES - A specimen consisting of a prostate, attached right and left seminal vesicles and. attached segments of right and left vasa deferentia. The prostate gland (4.5 x 4.5 X 3.9 cm, 42 grams, post fixation) has the usual shape. The soft tissue present along the. right. and. left posterolateral aspects of the prostate appears symmetrical. A nodule is palpated on the left anterior surface of the. prostate. Serial cross sections after fixation demonstrate a firm area consistent with tumor in the anterior portion of the prostate. of. both cross sections. The seminal vesicles and segments of vasa deferentia are grossly free of tumor. SECTION CODE: C1-C3, right seminal vesicle and segment of right vas deferens; C4-C6, left seminal vesicle and. segment of left vas deferens; C7, C8, prostatic base, right border; C9, C10, prostatic base, right posterior border; C11-C18,. prostatic. base,. central portion; C19, prostatic base, left border; C20, prostatic base, left posterior border; C21, C22, apex anterior;. C23-C25, apex left; C26-C29, apex posterior; C30, C31, apex right; C32-C41, sections of the two cross sections of the prostate. according to specimen radiograph. The anterior aspect of the prostate is inked in green, left surface in red, right surface in yellow and posterior surface in. black. Blue ink (C21 and C22) denotes surfaces that do not representative the true margin of resection. SNOMED CODES. Page: 4. Released by: END OF REPORT-.
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TCGA-CR-7390.3dfbab9d-ed2c-49dd-a7d5-b67fa8fb921b
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DIAGNOSIS: 1) TONGUE, RIGHT, BIOPSY: MODERATELY-DIFFERENTIATED INVASIVE SQUAMOUS CELL. CARCINOMA. 2) MOUTH, PALATAL MARGIN, EXCISION: NEGATIVE FOR MALIGNANCY. 3) MOUTH, FLOOR, MARGIN, EXCISION: NEGATIVE FOR MALIGNANCY. 4) BUCCAL MARGIN, EXCISION: NEGATIVE FOR MALIGNANCY. 5) LYMPH NODES, RIGHT NECK LEVEL 2 AND 3, EXCISION: 13 LYMPH NODES,. NEGATIVE FOR MALIGNANCY (0/13). 6) LYMPH NODES, RIGHT NECK LEVEL 1B, EXCISION: 2 LYMPH NODES, NEGATIVE FOR. MALIGNANCY (0/2). 7) TEETH: FOR MACROSCOPIC EVALUATION ONLY [SEE GROSS DESCRIPTION]. 8) ORAL CAVITY, "RIGHT TONGUE CANCER LEVEL 1B", RESECTION: MODERATELY-DIFFERENTIATED - INVASIVE SQUAMOUS CELL CARCINOMA INVOLVING RIGHT. TONGUE AND MOUTH FLOOR, WITH INVASION INTO THE DEEP TONGUE MUSCLES AND NO. INVASION INTO MANDIBLE, 5.0 CM IN GREATEST DIMENSION, ALL MARGINS NEGATIVE. [CLOSEST MARGIN (POSTERIOR) 0.6 CM]. 9) LYMPH NODE, PREHYOID, EXCISION: 1 LYMPH NODE, NEGATIVE FOR MALIGNANCY. (0/1). COMMENT: These findings correspond with AJCC pathologic Stage IVA (pT4a,. pNo). Upper Aerodigestive Tract and Minor Salivary Glands Carcinoma. Summary of Findings: Specimen Type: En-bloc resection: right tongue, mandible, floor of mouth. and other associated tissues. Tumor Site: Right lateral tongue. Tumor Size: 5 cm X 4.8 cm. Histologic Type: squamous cell carcinoma. Histologic Grade: Moderately differentiated. 4) SOURCE: Buccal Margin. Received fresh for frozen section diagnosis in a container labeled "buccal. margin" is 1 fragment of soft tissue that measures 8.3 X 0.2 X 0.3 cm. The. specimen is entirely submitted for frozen section diagnosis. Summary of sections: 4AFSC, frozen section control, 3/1. 5) SOURCE: Right Neck Level 2 and 3. Received fresh in a container labeled "right neck level 2, 3" are multiple. fragments of fibrofatty tissue that in aggregate measure 9.0 X 6.0 X 2.3. cm. The specimen is searched for lymph nodes and 12 possible lymph nodes. are identified. Two possible lymph nodes are submitted entirely in cassette. 5A. Two possible lymph nodes are submitted entirely in cassette 5B. One. possible lymph node is bisected and submitted in cassette 5C. One possible. lymph node is bisected and submitted in cassette 5D. One possible lymph. node is bisected and submitted in cassette 5E. One possible lymph node is. bisected and half in submitted in cassette 5F and half is submitted in. cassette 5G. One possible lymph node is bisected and half is submitted in. cassette 5A and half is submitted in cassette 5H. One possible lymph node. is bisected and submitted in cassette 5J. One possible lymph node is. bisected and submitted in cassette 5K and one possible lymph node is. bisected and submitted in cassette 5L. Summary of sections: 5A-5E, 2/1 each; 5F-5I, 1/1 each; 5J-5L, 2/1 each. 6) SOURCE: Right Neck Level 1B. Received fresh in a container labeled "right neck level 1B," is one. fragment of fibrofatty tissue that measure 6.3 cm X 3.5 X 0.8 cm. The. specimen is searched for lymph nodes and 2 possible lymph nodes are. identified. One possible lymph node is bisected and submitted in cassette. 6A. A second possible lymph node is bisected and submitted in cassette 6B. Summary of sections: 6A, 2/1 each. 7) SOURCE: Teeth. Received fresh in a container labeled "teeth for gross only" are 6 incisors. that in aggregate measure 5.0 X 4.0 X 0.7 cm. There do not grossly appear. to be any cavities or fillings. A photograph is taken and the specimen is. submitted for gross only pathologic diagnosis. 8) SOURCE: Right Tongue Cancer Level 1B. Received in formalin in a container labeled "right tongue cancer level 1B". is a portion of right tongue with attached mandible and soft tissue that. measures 11 X 10 X 7.5 cm. The tongue measures 10 cm from anterior to. posterior, 4.5 cm from right to left, and 3.3 cm from superior to inferior. The attached mandible measures 5.6 cm from anterior to posterior, 0.6 cm. from right to left, and 3.2 cm from superior to inferior. The specimen is. inked as follows: anterior orange, lateral read, medial yellow, posterior. black and inferior green. There is an ulcerated tumor at the right floor of. the mouth that measures 5.0 X 4.8 cm. A portion of the tumor is given to. research is placed in glutaraldehyde and also submitted in - -80 degree. The. medial soft tissue margin closest to the tumor is submitted in cassette 8A. and 8B. This margin appears grossly to be 1.8 cm away from the tumor. The. inferior margin to tumor is submitted in cassette 8C. This margin appears. to be 0.3 cm from tumor. There is a submandibular gland inferior to the. specimen that measures 4.3 X 2.5 X 2.3 cm. The tumor does not appear. grossly to extend into this gland. Representative sections of the gland are. submitted in cassette 8D and 8E. Posterior soft tissue margins to tumor is. submitted in cassette 8F. This margin grossly appears to be 0.4 cm away. from tumor. The anterior tongue margin is submitted in cassette 8G. The. anterior soft tissue margin is submitted in cassette 8H and this margin. appears grossly to be 1.5 cm away from tumor. Another posterior soft tissue. margin that appears grossly to the 0.4 cm away from tumor is submitted in. cassette 8I. A representative section of superior tongue tumor is submitted. in cassette 8J. The superior portion of the tongue appears to be grossly. involved by tumor. The lateral margin is composed of the mandible. The. anterior mandibular margin is submitted in cassette 8K. The posterior. mandible margin is submitted in cassette 8L. The lateral mandibular margin. to tumor is submitted in cassette 8M. Grossly, the mandible does not appear. to be involved by tumor. Representative sections of tumor are submitted in. cassette 8N-8R. Summary of sections: 8A-8Q, 1/1 each; 8R, 2/1; cassettes 8K, 8L and 8M are. submitted following decalcification. 9) SOURCE: Prehyoid Lymph Node. Received fresh in a container labeled "prehyoid lymph node" is one fragment. of fibrofatty tissue that measures 1.0 X 1.0 cm X 0.4 cm. The fragment is. entirely submitted in cassette 9A. Summary of sections: 9A, 1/1. Source 1 only. Slides and report reviewed by Attending Pathologist. SURGICAL PATHOLOGY INTRAOPERATIVE CONSULTATION. 1) SOURCE: Right Tongue. FROZEN SECTION DIAGNOSIS: SQUAMOUS CELL CARCINOMA. 2) SOURCE: Palatal Margin. FROZEN SECTION DIAGNOSIS: BENIGN. 3) SOURCE: Floor of Mouth Margin. FROZEN SECTION DIAGNOSIS: BENIGN. 4) SOURCE: Buccal Margin. FROZEN SECTION DIAGNOSIS: Attending Pathologist. The following special studies were performed on this case and the. interpretation is incorporated in the diagnostic report above: 3xDECALCIFICATION OF BLOCK. In some tests, analyte specific reagents (ASRs) are used. In the case of. an ASR, this test was developed and its performance characteristics. determined by this laboratory. It has not been cleared or approved by the. US Food and Drug Administration. The FDA has determined that such. clearance or approval is not necessary. This test is used for clinical. purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement. Amendments of. (CLIA. as qualified to perform high complexity. clinical laboratory testing.
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TCGA-C4-A0F1.8410F811-09E4-40B9-B3CF-5A6F3DE628BD
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Diagnosis. 1. Cystoprostatectomy preparation with a moderately differentiated, solid urothelial. carcinoma of squamous epithelial differentiation mainly in the right trigone, with penetration. of all parietal layers and macroscopic infiltration of the perivesical fatty tissue. Three tumor-. free lymph nodes. Deep resection margins, including urethra, ureters and vas deferens, are. tumor-free (compare frozen section, admission no.---). Foci of moderate dysplasia of the. remaining bladder urothelium. Comment: Tumor classification of the bladder carcinoma: pT3b, pNO (0/9), L0, V0, R0, G2; maximum. tumor size 2.5 cm.
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TCGA-HU-8249.508931ee-5e93-4e0b-bb41-0e6f85df5570
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Stomach, total gastrectomy: Advanced gastric carcinoma. Muc2(-)/Muc5AC(-)/Muc6(-)/CD10(++)/cERB2(-), type). 1. Location : middle third, Center at mid-body, lesser curvature. 2. Gross type : Borrmann type 2. 3. Histologic type : Adenocarcinoma, tubular moderately differentiated. 4. Histologic type by Lauren : intestinal. 5. Growth pattern: mixed expanding and infiltrative growth pattern. 6. Size : 7.4x6.5cm. 7. Depth of invasion : Tumor invades subserosa (pT3). 8. Resection margin : free from carcinoma. safety margins: distal 8.2cm, proximal 1.9cm. 9. Lymph node metastasis : metastasis to 5 out of 99 regional lymph nodes (pN2). (lesser curvature 5/47, greater curvature 0/52, #11 LN 0/0, #12 LN 0/0). 10. Lymphatic invasion : present, mild. 11. Venous invasion : present, moderate. 12. Perineural invasion : present, mild. 13. Additional findings : - Spleen, no tumor. - Accessory spleen is identified, 0.5x0.4cm in size. - Pit dysplasia in adjacent mucosa. Specimen labeled as "anvil ring", biopsy: No tumor. Small intestine, jejunum, biopsy: No tumor. # Immunohistochemistry : CD10, MUC2, MUC5ac, MUC6, C-erb B2.
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TCGA-BR-6801.975674c1-7cb6-4e9e-b9e4-32ff2504e260
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STOMACH TISSUE CHECKLIST. Specimen type: Subtotal gastrectomy. Tumor site: Stomach. Tumor size: 9x7x1cm. Tumor features: Ulcerated. Histologic type: Adenocarcinoma. Histologic grade: Moderately. differentiated. Tumor extent: Adjacent structures. (specify) - greater omentum. Lymph nodes: 0/8 positive for. metastasis (Regional 0/8). Lymphatic invasion: Not specified. Venous invasion: Not specified. Perineural invasion: Not specified. Margins: Uninvolved. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not. specified. Comments: None.
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TCGA-SX-A7SL.C495D1B8-5AAE-425D-B11B-77C84F928280
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DIAGNOSIS: A. Left kidney: Papillary renal cell carcinoma, grade 1/4, 4 cm,. confined to the kidney. Procedure/laterality: Left robotic nephrectomy. Histologic type Papillary renal cell carcinoma, type I. Nuclear grade (Fuhrman, 1-4) : Grade 1/4. Tumor size: 4 X 3.7 X 3.7 cm. Tumor site: Upper pole left kidney. Tumor focality: A single circumscribed lesion in the cortex. Sarcomatoid features: Absent. Tumor necrosis: Absent. Microscopic tumor extension: No extension into perinephric tissue,. renal sinus, renal vein or collecting system. Surgical margins The external soft tissue and ureteral margins are. negative for carcinoma. Lymph-vascular invasion: Absent. Lymph nodes Absent. Pathologic findings in nonneoplastic kidney Adjacent to the. carcinoma there is a 2 cm unilocular renal cyst. Sections of cortex away from the carcinoma show less than 58. sclerotic glomeruli, minimal interstitial fibrosis, some dilated. atrophic tubules, and severe renal artery and intra-renal artery. atherosclerosis. Pathologic staging: pTla, pNX. Biorepository sample (if applicable) : Yes, non-malignant cortex and. carcinoma. Block (s) containing malignancy suitable for additional testing: A1,. A3, A4, A5. The frozen section diagnosis is confirmed by the permanent sections. CLINICAL INFORMATION: Left renal mass. SPECIMEN (S) : A:Left kidney. PRELIMINARY INTRAOPERATIVE DIAGNOSIS: A. Left kidney, frozen section diagnosis : Papillary renal cell. carcinoma. GROSS DESCRIPTION: and "left kidney". Procedure : Radical nephrectomy. Specimen laterality: Left. Tumor site: Upper pole. Tumor size: 4.0 x 3.7 x 3.7 cm. Tumor focality: Unifocal. Gross extent of tumor: Extension into perinephric tissue: : Absent. Extension beyond Gerota's fascia: Absent. Extension into renal sinus: : Absent. Extension into renal vein: Absent. Extension into collecting system: Absent. Adrenal gland: Absent. Gross notes: Gross tumor characteristics : Well-demarcated, tan and a rubbery. mass with somewhat obulated-appearing cut surfaces with a couple. foci of yellow-orange, moderately soft areas measuring up to 1.2 cm. in greatest dimension. Kidney weight : 564 g with fat; weight without fat 165 g. Kidney dimensions: 11.5 X 6.0 x 4.7 cm. Ureter dimensions: Length--8.5 cm and diameter--0.4 cm. Lymph nodes : None identified. Inking details: : The outer-most surface of the fat adjacent to. the mass is inked blue. Biorepository sample submitted: Yes, see block key. Other findings : Abutting the mass, there is a 2.0-cm in greatest. dimension unilocular cyst compartment containing tan, clear fluid. The inner cyst lining is smooth. Block key for specimen A: A1) representative section of mass submitted for frozen section. A2) ureter margin and vascular margins at hilum, shave. A3-A4) - mass in relation to inked outer surface of adjacent fat. A5) mass in relation to adjacent cystic structure. A6) mass in relation to adjacent parenchyma and superior calyx. A7) inferior pole, to include parenchyma and inferior calyx. A8) mirror image of tissue submitted for. (grossly. normal parenchyma and tumor).
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TCGA-MH-A857.465C49A8-2050-434A-AC95-9144E46972DB
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---- SURGICAL PATHOLOGY. MEDICAL RECORD. Laboratory: Accession No. Submitted by: Date obtained: Specimen (Received. A.BASE OF LEFT RENAL TUMOR F.S. B.LEFT RENAL PERITUMOR FAT. C.LEFT RENAL TUMOR. BRIEF CLINICAL HISTORY: PREOPERATIVE DIAGNOSIS: left renal mass. OPERATIVE FINDINGS. POSTOPERATIVE DIAGNOSIS: left renal mass. Laboratory: Accession No. GROSS DESCRIPTION: A. The specimen is received fresh for intraoperative consultation and. consists of a 1.2 X 0.4 X 0.3 cm tan-yellow irregular tissue fragment. that is submitted in toto for frozen and permanent section in cassette. FsA. FROZEN SECTION DIAGNOSIS: FsA. Base of left renal tumor, biopsy: - NO TUMOR SEEN. B. The specimen consists of a 173 gm, 11.2 X 6.5 x 3.2 cm tan-yellow. aggregate of fatty soft tissue partially surfaced by a tan-pink smooth. glistening peritoneal surface. No discrete lesions are identified. Sectioning reveals a tan-yellow unremarkable fatty cut surface. Representative sections are submitted in cassettes B1-B6. C. The specimen consists of a 54.7 gm, 5.5 X 5.2 X 3.8 cm partial. nephrectomy specimen partially surfaced by a tan-brown scabrous renal. resection margin. The capsular margin is partially surfaced by tan. yellow lobulated fat. The renal resection margin is inked blue and. the capsular margin is inked black. The specimen is serially sectioned to reveal a 4.6 x 3.8 X 3.2 cm. tan-yellow to brown to red variegated poorly demarcated mass that. grossly extends less than 1 mm from the renal resection margin and 0.4. cm from the overlying Gerota's fascia/capsular margin. There is a. minimal amount of uninvolved renal parenchyma at the renal resection. margin. Representative sections of the majority of the mass, to include the. capsular and renal resection margins, are submitted sequentially in. cassettes C1-C17. (Please note that a representative portion is taken. for. MICROSCOPIC EXAM. DIAGNOSIS: A. Base of left renal tumor, excision: - NO TUMOR IDENTIFIED. B. Left renal peritumor fat, excision: - FIBROADIPOSE TISSUE, NO TUMOR IDENTIFIED. C. Left renal tumor, partial nephrectomy : - PAPILLARY RENAL CELL CARCINOMA. - CHROMOPHOBE RENAL CELL CARCINOMA. (SEE SYNOPTIC REPORT). SYNOPTIC REPORT: PROCEDURE: Partial nephrectomy. SPECIMEN LATERALITY: Left. TUMOR SIZE: Greatest dimension: 1.8 cm (chromophobe renal cell carcinoma). 1.6 cm (papillary renal cell carcinoma). TUMOR FOCALITY: Multifocal. MACROSCOPIC EXTENT OF TUMOR: Tumor limited to kidney. HISTOLOGIC TYPE: Papillary renal cell carcinoma. Chromophobe renal cell carcinoma. SARCOMATOID FEATURES: Not identified. TUMOR NECROSIS: Present. HISTOLOGIC GRADE: G2 (papillary renal cell Carcinoma). Not applicable (chromophobe renal cell carcinoma). MICROSCOPIC TUMOR EXTENSION: Tumor limited to kidney. MARGINS : Margins uninvolved by invasive carcinoma. (Closest margin: Papillary renal cell carcinoma. 1 mm from capsular margin;. Chromophobe renal cell carcinoma 1 mm from renal. parenchymal margin). LYMPH-VASCULAR INVASION: Not identified. PATHOLOGIC STAGING: Chromophobe renal cell carcinoma: pT1, pNX, pMX. Papillary renal cell carcinoma: pT1, pNX, pMX. COMMENT: By immunohistochemistry the chromophobe RCC is positive for. CK7, and negative for CD15, vimentin and 504s. The papillary RCC is. positive for 504s. - concurs with the diagnosis. Physician was notified at the. time of frozen section and via. on. Immunohistochemistry Disclaimer: "This test was developed and its. performance characteristics determined by the. at the. It has not been cleared or approved by the U.S. Food and Drug. Administration. The FDA has determined that such clearance or approval. is not necessary. This test is used for clinical purposes. It should. not be regarded as investigational or for research. This Laboratory is. certified under the Clinical Laboratory Improvement Amendments of 1988. (CLIA-88) as qualified to perform high complexity clinical laboratory. testing.'.
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TCGA-44-6777.600a1078-21f2-4267-9d3c-03f292fa6a32
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Date Recd: SPECIMEN. Left upper lobe wedge resection. CLINICAL NOTES. PRE-OP DIAGNOSIS: Lung cancer. GROSS DESCRIPTION. Received fresh, subsequently fixed in formalin, labeled. "left upper lobe wedge resection". The specimen consists. of a wedge of lung which is 78 gram. The specimen is 15 X 5.5 X 4. cm. and has a stapled margin of 15 cm. The pleura is violaceous. smooth and glistening. There is a 1 X 1 cm. umbilication in the. pleura. This focus is inked and the specimen is sectioned to show a. 3.5 X 2.5 X 2.4 cm. pink tan tumor which shows fibrous stippling. present. This is contiguous within the pleural umbilication. Representative tissue was submitted for tumor procurement. The tumor. comes within 1.5 cm. of the sacral margin (inked black) . The. remainder of the cut surface of the lung is pink tan and spongy. showing no other discrete gross lesions. Representative sections of. the specimen are submitted as follows: BLOCK SUMMARY: 1-4 - Representative section of tumor including. pleural umbilicatio nd surgical stapled margin; 5 - representative. of normal. RS-5. MICROSCOPIC DESCRIPTION. Histologic type: Adenocarcinoma. Histologic grade: Poorly differentiated. Primary tumor (pT) : The tumor measures 3.5 cm. in maximum dimension. and is limited to the lung parenchyma in the wedge specimen and. invades into the pleura, pT2. Margins of resection: Negative. Vascular invasion: Present. Regional lymph nodes (pN) : pNX. Distant metastasis (pM) : pMX. Other findings: A small piece of tissue from the tumor and normal. tissue is submitted for the tumor bank. 4x1. DIAGNOSIS. Lung, left upper lobe wedge resection -. Invasive poorly-differentiated adenocarcinoma (see tumor. characteristics in the lung template in the microscopic. description). End Of Report ---.
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TCGA-DU-7010.B62E7173-FC3E-4D4C-B9C0-37110B1B58E8
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Anatomic Pathology/Cytology Document State: (version). Update Date/Time: Service Date/Time: Female Provider: Responsible Staff: SURGERY DATE: RECEIVE DATE: PATIENT PHONE NO. : PATHOLOGICAL DIAGNOSIS: BRAIN BIOPSY, LEFT FRONTAL LOBE: ASTROCYTOMA, GEMISTOCYTIC. Operation/Specimen: Left frontal lobe lesion FS. Clinical History and Pre-Op Dx: Anaplastic astrocytoma. with. radiation. GROSS PATHOLOGY : Multiple 0.4-1.0 cm tissue fragments. INTRAOPERATIVE CONSULTATION, Frozen section diagnosis: Glioma in # 1-. 4. MICROSCOPIC: Sections show neoplastic astrocytic infiltration with. focal areas of hypercellular density. The predominant neoplastic cells. are gemistocytic astrocytes with frequent nuclear hyperchromasia and. pleomorphic. Mitotic figures are rare. There is mild endothelial. proliferation. Necrotic foci are not seen. Focal aggregates of. lymphocytic cells are seen within the tumor. Radiation necrosis is not. present in the sections. TISSUE COMMITTEE CODE: TC1.
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TCGA-56-7579.fd7a1de0-aa43-4d5a-b1e4-67473689bd58
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FINAL SURGICAL PATHOLOGY REPORT. Diagnosis: A. -N.) LUNG, LEFT, WITH SUBCARINAL (N7), RIGHT HILAR (N10R), LEFT HILAR. (N10LX2), RIGHT AND LEFT LOWER PARATRACHEAL (N4R, N4L), SUBAORTIC (N5),. INTRALOBAR (N11L), PULMONARY LIGAMENT (N9LX2), AND PARA-AORTIC (N6). LYMPH NODES, PNEUMONECTOMY WITH REGIONAL LYMPHADENECTOMY: INVASIVE MODERATELY DIFFERENTIATED SQUAMOUS CELL CARCINOMA. - Involves left upper lobe and mainstem bronchus. - 7.5 cm in maximum dimension. - Visceral pleura invasion: Not identified. - MARGIN STATUS: NEGATIVE. - Bronchial and vascular margins uninvolved by invasive carcinoma. = THREE HILAR AND PERIBRONCHIAL) LYMPH NODES, OUT OF THIRTY TOTAL. LYMPH NODES, POSITIVE FOR METASTATIC CARCINOMA (3/30). - SEE TUMOR STAGING SUMMARY BELOW. PATHOLOGIC STAGING SUMMARY: - Type and grade: Squamous cell carcinoma, moderately differentiated. = Primary tumor: pT3 (7.5 cm in maximum dimension). - Regional lymph nodes: pN1 (3 [hilar and peribronchial] out of 30 total lymph nodes,. positive for metastasis; 3/30). - Distant metastasis: pMX. - Pathologic stage: IIIA. - Lymphovascular invasion: Present. - Margin status: R0. COMMENT: The above findings were discussed at. Conference on. FINAL SURGICAL PATHOLOGY REPORT. Lung Tumor Staging Information. (data derived from current specimen, staging in accordance with or modified from AJCC Cancer Staging. Handbook, 7th Ed, and CAP protocol,. Specimen: Lung. Procedure: Pneumonectomy. Specimen integrity: Intact. Specimen laterality: Left. TUMOR FEATURES: Tumor site: Upper lobe and mainstem bronchus. Tumor size: Greatest dimension: 7.5 cm. Additional dimensions: 6 X 6 cm. Tumor focality: Unifocal. Histologic type: Squamous cell carcinoma. Histologic grade: Moderately differentiated (G2). Visceral pleura invasion: Not identified. Tumor extension: Tumor involves main bronchus distal to the carina, but. does not involve the carina. MARGINS: R0 (Negative). Bronchial margin: Uninvolved by invasive carcinoma. Vascular margin: Uninvolved by invasive carcinoma. Parenchymal margin: Not applicable. Pariental pleural margin: Not applicable. Chest wall margin: Not applicable. Other attached soft tissue margin: Not applicable. Treatment effect: Not applicable. Lymphovascular invasion: Present. Lymph nodes: Three (hilar and peribronchial) lymph nodes, out of. thirty total lymph nodes, positive for metastasis (3/30). PATHOLOGIC STAGING SUMMARY: Primary tumor: pT3 (7.5 cm in greatest dimension). Regional lymph nodes: pN1 (3/30 total lymph nodes). Distant metastasis: pMX. Pathologic stage: IIIA. Margin status: R0. Additional findings: Pulmonary edema, and post-obstructive pneumonitis. FINAL SURGICAL PATHOLOGY REPORT. Source of Specimen: A. Lymph node;N7. B. Lymph node;N10R. C. Lymph node;N10L. D. Lymph node;N4R. E. Lymph node;N2R. F. Lymph node;N4L. G. Lymph node;N5. H. N11L. I. Lymph node;N9L. J. Lymph node;N9L#. K. Lymph node;N7. L. Left Lung. M. Lymph node;N10L#. N. Lymph node;N6. Clinical History/Operative Dx: Left lung cancer. Intraoperative Diagnosis: A. FSA: N7 - Negative for metastasis. The intraoperative interpretation(s) was/were performed and rendered at. B. FSB: N10R - Negative for metastasis. C. FSC: N10L - Negative for metastasis. D. FSD: N4R - Negative for metastasis. E. FSE: N2R - Negative for metastasis. F. FSF: N4L - Negative for metastasis. Gross Description: A. The specimen is labeled N7 and is received without fixative. It consists of a 0.4 X 0.3 X 0.3 cm. fragment of yellow-brown to anthracotic tissue which is entirely submitted for frozen section as FSA. The. tissue remaining from frozen section is submitted for permanent section in cassette A1. B. The specimen is labeled N10R and is received without fixative. It consists of a 1 X 0.4 X 0.2 cm. aggregate of yellow-tan to anthracotic tissue which is entirely submitted in for frozen section as FSB. The. FINAL SURGICAL PATHOLOGY REPORT. tissue remaining from frozen section is submitted for permanent section in cassette B1. C. The specimen is labeled N10L and is received without fixative. It consists of two fragments of yellow-. tan anthracotic tissue which measure 1 X 0.4 X 0.3 cm in aggregate. The tissue is submitted for frozen. section as FSC. The tissue remaining from frozen section is submitted for permanent section in cassette. C1. D. The specimen is labeled N4R and is received without fixative. It consists of a 1 X 0.7 X 0.3 cm fragment. of fatty and anthracotic tissue which is submitted for frozen section as FSD. The tissue remaining from. frozen section is submitted for permanent section in cassette D1. E. The specimen is labeled N2R and is received without fixative. It consists of a 1 X 0.7 X 0.3 cm. aggregate of fatty appearing tissue. It is submitted for frozen section as FSE. The tissue remaining from. frozen section is submitted for permanent section in cassette E1. F. The specimen is labeled N4L and is received without fixative. It consists of a 0.7 X 0.6 X 0.3 cm. fragment of pale yellow and focally anthracotic tissue which is submitted for frozen section as FSF. The. tissue remaining from frozen section is submitted for permanent section in cassette F1. G. The specimen is labeled N5 and is received in formalin. It consists of a single 2.4 X 0.9 X 0.9 cm. fragment of yellow-tan and anthracotic tissue which appears to have been centrally partially transected. It. is serially sectioned and entirely submitted in cassette G1-G2. H. The specimen is labeled N11L and is received in formalin. It consists of a 1 1 X 0.6 X 0,6 cm fragment. of gray-tan and anthracotic tissue. It is trisected and submitted in cassette H1. I. The specimen is labeled N9L and is received in formalin. It consists of a 0.7 X 0.7 X 0.3 cm fragment of. fibrofatty tissue with three 0.2 - 0.3 cm discrete areas of anthracotic discoloration. The specimen is. submitted intact in cassette 11. J. The specimen is labeled N9L #2 and is received in formalin. It consists of a 0.7 X 0.5 X 0.4 cm fragment. of tan and anthracotic tissue. It is bisected and submitted in cassette J1. K. The specimen is labeled N7 and is received in formalin. It consists of seven fragments of tan to reddish. violet and anthracotic tissue varying from 0.7 X 0.4 X 0.4 cm to the largest fragment measuring 1.7 X 1.4 X. 0,5 cm. The largest fragment is serially sectioned and submitted in cassette K1. A second fragment is. serially sectioned and submitted in cassette K2. Two fragments are serially sectioned and submitted in K3. (one inked). The three remaining fragments are submitted in cassette K4 (each inked and bivalved). L. The specimen is labeled left lung and is received without fixative. It consists of a pneumonectomy. specimen which weighs 628 grams. It measures 24 X 15 X 7 cm. The pleural surface of the left upper lobe. is pink-tan at the apical portion becoming consolidated red-violet and hemorrhagic in the basilar portion. of the lung. At the interlobar fissure there are multiple fibrous adhesions. The pleural surface of the lower. lobe is violet-tan adjacent to the interlobar fissure and is pink to pale tan along the basilar portion. At the. hilum of the lung the main bronchus is identified. The bronchus is surrounded by moderately firm. ES. FINAL SURGICAL PATHOLOGY REPORT. fibrofatty tissue with embedded anthracotic nodes. The upper lobe bronchus is obstructed with thick. mucous and possible tumor. The lower lobe bronchus appears patent. The bronchial margin is removed. as a thin shave and submitted for frozen section. Serial sections of the lung reveal glistening tan-white. tumor blocking and obstructing the upper lobar bronchus. Proceeding laterally tumor tracks outward along. the bronchi into the lung parenchyma over an area measuring 7.5 X 6 X 6 cm. There is consolidation and. yellowish firmness of the surrounding pulmonary parenchyma throughout most of the upper lobe. The. apical lung tissue is pink to tan and appears aerated. There is bronchiectasis of the lateral portion of the. upper lobe. The tumor does not involve the pleural surface but along the posterior apical portion of lung. is 0.3 cm from the pleural surface. There are additional anthracotic nodes along the lobar and segmental. bronchi. The superior edge of the inferior lobe appears consolidated and in one central area tumor is. within 0.7 cm of the inferior lobe. The parenchyma of the inferior lobe away from the interlobar fissure. is. red and consolidated. Representative sections are submitted. Section summary: L1) bronchial margin. from frozen section, L2-L3) vascular margin, L4-L5) hilar nodes, L6-L7) representative larger peribronchial. nodes, L8) tumor plug in main bronchus, L9-L12) representative sections of tumor from upper lobe. progressing from main bronchus laterally, L13) tumor with closest approach to posterior upper lobe pleural. surface, L14) interlobar fissure with closest approach to tumor to lower lobe, L15) upper lobe parenchyma. away from tumor, L16) representative lower lobe parenchyma. M. The specimen is labeled N10L #2 and is received in formalin. It consists of two 1.1 - 1.2 cm ovoid. fragments of gray-tan and partially anthracotic tissue. The tissue is serially sectioned and entirely. submitted in cassettes M1-M2 respectively. N. The specimen is labeled N6 and is received in formalin. It consists of a 1.3 X 0,6 X 0.5 cm fragment of. fibrofatty and anthracotic tissue. It is bisected and submitted in cassette N. Microscopic Description: A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. B. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. C. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. D. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. E. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. F. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. G. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. FINAL SURGICAL PATHOLOGY REPORT. rendered. H. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. I. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. J. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. K. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. L. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. M. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. N. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered.
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TCGA-34-7107.e944ec22-44f1-4a7c-a06c-50e0d2d167a9
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FINAL DIAGNUSIS: PART 1: LYMPH NODE, RIGHT LEVEL 10, BIOPSY -. ANTHRACOTIC LYMPH NODE FREE OF CARCINOMA. PART 2: LYMPH NODE, RIGHT DEEP LEVEL 4, BIOPSY -. ANTHRACOTIC LYMPH NODE FREE OF CARCINOMA. PART 3: LYMPH NODE, RIGHT LEVEL 4, BIOPSY-. ANTHRACOTIC LYMPH NODE FREE OF CARCINOMA. PART 4: SOFT TISSUE, RIGHT POSTERIOR CHEST WALL, EXCISION -. A. PORTION OF LUNG WITH INFLAMMATORY CHANGES, ORGANIZING PNEUMONIA, FIBRIN DEPOSITION AND. NECROSIS. B. NO EVIDENCE OF MALIGNANCY. PART 5 LYMPH NODE, LEVEL 7, BIOPSY -. A. ANTHRACOTIC LYMPH NODE WITH LIPID GRANULOMAS. B. NO EVIDENCE OF MALIGNANCY. PART 6: LUNG, RIGHT, PNEUMONECTOMY -. 1. A. INVASIVE MODERATELY DIFFERENTIATED SQUAMOUS CELL CARCINOMA ASSOCIATED WITH EXTENSIVE. NECROSIS, 4.5 CM. B. NO DEFINITIVE ANGIOLYMPHATIC INVASION IDENTIFIED. C. EIGHT (8) HILAR LYMPH NODES FREE OF CARCINOMA. D. SURGICAL RESECTION MARGINS FREE OF CARCINOMA. E. TNM STAGE (AJCC, 7th Edition): pT2a NO. PART 7: BONE, RIGHT FIFTH RIB, PARTIAL RESECTION -. PORTION OF BONE, FREE OF CARCINOMA. PART 8: PLEURA, RIGHT PARIETAL, RESECTION -. A. PORTION OF LUNG WITH ORGANIZING PNEUMONIA. B. PLEURA WITH CHRONIC INFLAMMATION AND FIBROSIS. c. NO EVIDENCE OF MALIGNANCY. PART 9 LYMPH NODE, RIGHT LEVEL 10, BIOPSY -. ANTHRACOTIC LYMPH NODE FREE OF CARCINOMA. PART 10 LYMPH NODE, RIGHT LEVEL 4, BIOPSY -. A. PORTION OF BENIGN ADIPOSE TISSUE. B. NO LYMPH NODE TISSUE IDENTIFIED. CASE SYNOPSIS: SYNOPTIC DATA - PRIMARY LUNG TUMORS. TUMOR LOCATION: Right Lower Lobe. PROCEDURE: Pneumonectomy. TUMOR SIZE: Maximum dimension: 4.5 cm. Minor dimension: 4 cm. GROSS SATELLITES: Number of gross satellite lesions: 0. TUMOR TYPE: Invasive squamous carcinoma, proximal type. HISTOLOGIC GRADE: G2, Moderately differentiated. MICROSCOPIC "SATELUTES"IMETASTASES: Number of microscopic lesions: 0. EXTRAPULMONARY EXTENSION/INVASION OF TUMOR: None identified. ANGIOLYMPHATIC INVASION: TUMOR NECROSIS: > 50%. SURGICAL MARGIN INVOLVEMENT: No. INFLAMMATORY(DESMOPLASTIC) REACTION: Severe. N1 LYMPH NODES: Number of N1 lymph nodes positive: 0. Number of N1 lymph nodes examined: 10. N2 LYMPH NODES: Number of N2 lymph nodes positive: 0. Number of N2 lymph nodes examined: 3. UNDERLYING DISEASE(S): Chronic interstitial pneumonia. T STAGE, PATHOLOGIC: pT2a. N STAGE, PATHOLOGIC: pNO. M STAGE, PATHOLOGIC: Not applicable.
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TCGA-BC-A10Z.427BA175-823D-4C68-B659-D53CFEB5EA45
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Diagnosis: A: Liver, right, resection. - Moderately differentiated invasive hepatocellular carcinoma. - Tumor size 12 cm. - Tumor extends to the green inked hepatic surgical margin. - Tumor necrosis is present. - Tumor extends to and through the capsule at a region of capsular disruption (A6). - Changes suggestive of thrombosis with recanalization. - Liver uninvolved by tumor shows mild intrahepatic cholestasis. B: Gallbladder, cholecystectomy. - Cholesterolosis. - No evidence of cholelithiasis. - Two lymph nodes, no tumor seen (0/2). Comment: None. Clinical History: The patient is with liver carcinoma. Gross Description: Two appropriately labeled containers are received. Container A is additionally labeled "right hepatic trisegment". The specimen was delivered to the gross. room by tissue procurement and subsequently placed in formalin. The specimen weighs 1280 gm, and. measures 19.5 x 17 x 12.5 cm. The surgical margin is inked green and demonstrates a rough irregular. surface. The liver capsule is red/brown, somewhat rubbery in architecture. A 6.7 x 3.0 x 3.0 cm somewhat. elliptical defect is present in the capsule of the liver from which a portion of the tumor has been removed. Serial sectioning reveals 12 x 11 x 10 cm well circumscribed white soft friable tumor. Throughout the. tumor there are scattered areas of black char-like pigment and areas of questionable necrosis. There are two foci of questionable extracapsular extension of the tumor. These areas are 1.0 cm in greatest. diameter and 0.5 cm in greatest diameter. Grossly the tumor appears to be less than 0.1 cm from the. surgical green inked margin and focally may extend to the margin. The remainder of the liver is tan/brown. with a somewhat micronodular pattern. Representative sections are submitted per block summary. A1-A2 - representative sections of tumor with adjacent surgical green inked margin. A3-A5 - representative sections of tumor. A6 - tumor at site of extracapsular extension. A7-A10 - representative sections of tumor. A11 - normal appearing liver. Container B is additionally labeled "gallbladder". Previously opened: Yes, there is one small foci in the distal portion of the gallbladder that is 0.3 cm in. greatest diameter. Measurements: 9.2 x 3.1 x 1.4 cm. External surface: Yellow/green/tan one surface of which is smooth and glistening and the opposite surface. is somewhat fibrotic which probably represents the hepatic attachment. There also are numerous fungating. yellow/tan nodules from the external surface at the distal portion of the gallbladder these nodules are 1.3 x. 1.0 x 0.8 cm. These nodules are also located at the proximal portion of the gallbladder and range in size. from 0.5 x 0.5 to 0.7 x 0.7 cm. Wall thickness: 0.2 cm. Mucosa: green velvety with cholesterolosis. Stones present: not identified. Other comments: none. Block B1: Cystic duct margin and representative section of lymph node located at the cystic duct as well as. nodules at the proximal portion of the gallbladder. B2: Representative sections of the body of the gallbladder and distal portion of gallbladder at site of. nodules. Light Microscopy: Light microscopic examination is performed. I have personally conducted the evaluation of the above specimens and have rendered the above. diagnosis(es).
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TCGA-B5-A1MW.870882D8-D89A-4A89-B516-DADAB95BE285
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CLINICAL HISTORY: Malignant neoplasm corpus uteri, 182.0. GROSS EXAMINATION: A. "Uterus, cervix, tubes and ovaries (AF1\". ceived fresh for frozen. section and placed in formalin at. is a 92 gram, 6.2 x 3.5 x. 3.5 cm uterus with a 2.5 cm diameter cervix with 0.8 cm diameter patent os. Attached to the uterus is a 6 x 1 cm grossly unremarkable right fallopian tube. and 4.5 x 1.2 x 1.2 cm grossly unremarkable right ovary. Also attached is a. 6.5 x 1 cm grossly unremarkable left fallopian tube, and 4.6 x 1.5 x 1.2 cm. grossly unremarkable left ovary. The cervix is grossly unremarkable. The. serosal surface of the uterus is smooth, glistening, and grossly. unremarkable. The 3.7 x 2.7 cm endometrial cavity is entirely filled by an exophytic,. friable mass. The mass appears to grossly involve the anterior and posterior. lower uterine segments. It comes within 3 cm of the distal cervix. The. exophytic mass is 1.5 cm deep and appears to grossly invade approximately 0.4. cm into a 1.3 cm thick myometrium. There are no other lesions noted in the. myometrium or remainder of the specimen. BLOCK SUMMARY: A1-. representative section of right ovary. A2-. representative section of right fallopian tube. A3-. representative section of left ovary. A4-. representative section of left fallopian tube. A5-. representative section of anterior cervix. A6-. anterior lower uterine segment with respect to mass. A7-. posterior cervix. A8-. mass with respect to posterior lower uterine segment. A9-13-. representative sections of mass. A14-. frozen section remnant with deepest invasion, AF1. B. "Left external lymph node", received fresh and placed in formalin at. is a 3 x 2 x 1 cm aggregate of fibroadipose tissue dissected for. candidate lymph nodes. BLOCK SUMMARY: B1- largest candidate lymph node, 1.8 cm in greatest dimension. B2- two candidate lymph nodes, 0.8 cm in greatest dimension. B3- remaining fibroadipose tissue. C. "Left obturator node", received fresh and placed in formalin at. on. is a 5 x 2.5 x 1.5 cm aggregate of fibroadipose tissue dissected for. candidate lymph nodes. BLOCK SUMMARY: C1- largest candidate lymph node, 1.4 cm in greatest dimension, bisected. C2- two candidate lymph nodes, 1.5 cm in greatest dimension. C3- three candidate lymph nodes, 1.2 cm in greatest dimension. C4- three candidate lymph nodes, 0.8 cm in greatest dimension. C5- remaining fibroadipose tissue. D. "Right pelvic node", received fresh and placed in formalin at. I on. is a 5 x 3 x 1.8 cm aggregate of fibroadipose tissue dissected for. candidate lymph nodes. BLOCK SUMMARY: D1- two candidate lymph nodes, 1.2 cm in greatest dimension. D2- four candidate lymph nodes, 0.8 cm in greatest dimension. D3- three candidate lymph nodes, 1 cm in greatest dimension. D4- six candidate lymph nodes, 0.5 cm in greatest dimension. D5- remaining fibroadipose tissue. E. "Left aortic node", received fresh and placed in formalin at. on. is a 1.5 x 1 x 0.8 cm aggregate of fibroadipose tissue dissected for. candidate lymph nodes. BLOCK SUMMARY: E1- three candidate lymph nodes, 0.5 cm in greatest dimension. E2- remaining fibroadipose tissue. F. "High left aortic node", received fresh and placed in formalin at. pm. on. is a 1.5 x 1 x 0.6 cm candidate lymph node, bisected, and submitted. in block F1. G. "Right aortic lymph node", received fresh and placed in formalin at. pm. on. is a 2.5 x 1.5 x 1 cm aggregate of fibroadipose tissue dissected. for candidate lymph nodes. BLOCK SUMMARY: G1- 3 x 0.8 x 0.6 cm lymph node, bisected. G2- two candidate lymph nodes, 0.6 cm in greatest dimension. G3- remaining fibroadipose tissue. Dr. /Dr. /slides to Dr. INTRA OPERATIVE CONSULTATION: A. "Uterus, cervix, tubes, and ovary": AF1- (representative mass) - high-grade. malignancy. The tumor invades less. than half of the myometrial thickness. (one section examined) (Dr. MICROSCOPIC EXAMINATION: Microscopic examination is performed. PATHOLOGIC STAGE: PROCEDURE: Hysterectomy, bilateral salpingo-oophorectomy, lymph node sampling. PATHOLOGIC STAGE (AJCC 7th Edition) : pTla pNO pMX. NOTE: Information on pathology stage and the operative procedure is. transmitted to this Institution's Cancer Registry as required for. accreditation by the Commission on Cancer. Pathology stage is based solely. upon the current tissue specimen being evaluated, and does not incorporate. information on any specimens submitted separately to our Cytology section,. past pathology information, imaging studies, or clinical or operative. findings. Pathology stage is only a component to be considered in determining. the clinical stage, and should not be confused with nor substituted for it. The exact operative procedure is available in the surgeon's operative report. DIAGNOSIS: A. UTERUS, CERVIX, TUBES AND OVARIES (HYSTERECTOMY AND BILATERAL. ILPINGO-OOPHORECTOMY) : UTERUS: 92 GRAMS. CARCINOMA OF THE ENDOMETRIUM: TUMOR SITE: DIFFUSE. HISTOLOGIC TYPE: ENDOMETRIOID ADENOCARCINOMA. FIGO GRADE: 3. TUMOR SIZE: 3.7 X 2.7 X 1.5 CM. MAXIMUM DEPTH OF MYOMETRIAL INVASION: 0.4 CM, IN A 1.3 THICK WALL. LYMPHATIC/VASCULAR INVASION: ABSENT. ADJACENT NON-NEOPLASTIC ENDOMETRIUM: ABSENT. REMAINING MYOMETRIUM: ADENOMYOSIS. CERVIX: FREE OF TUMOR. SEROSA: FREE OF TUMOR. SPECIMEN MARGINS: NOT INVOLVED. OVARIES, RIGHT AND LEFT: FREE OF TUMOR. FALLOPIAN TUBE, RIGHT AND LEFT: FREE OF TUMOR. B. LEFT EXTERNAL LYMPH NODE (LYMPH NODE DISSECTION) : TWO LYMPH NODES, NEGATIVE FOR CARCINOMA (0/2) . C. LEFT OBTURATOR NODE (LYMPH NODE DISSECTION) : ELEVEN LYMPH NODES, NEGATIVE FOR CARCINOMA (0/11). D. RIGHT PELVIC NODE (LYMPH NODE DISSECTION) : EIGHTEEN LYMPH NODES, NEGATIVE FOR CARCINOMA (0/18) . E. LEFT AORTIC NODE (LYMPH NODE DISSECTION) : THREE LYMPH NODES, NEGATIVE FOR CARCINOMA (0/3) . F. HIGH LEFT AORTIC NODE (BIOPSY) : ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). G. RIGHT AORTIC LYMPH NODE (LYMPH NODE DISSECTION) : FOUR LYMPH NODES, NEGATIVE FOR CARCINOMA (0/4). I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es). CI ADDENDUM 1: Please see Image Cytometry Report. for results of supplementary. tests. certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es) .
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TCGA-E6-A1M0.F1AF61FE-BF05-49E2-85DA-F4CE37596DEA
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SPECIMENS: A. UTERUS, TUBES AND OVARIES. B. LEFT PELVIC NODES. C. RIGHT PELVIC NODES. D. RIGHT ILIAC NODE. E. PERI-AORTIC LYMPH NODES. F. OMENTUM. SPECIMEN(S): A. UTERUS, TUBES AND OVARIES. B. LEFT PELVIC NODES. C. RIGHT PELVIC NODES. D. RIGHT ILIAC NODE. E. PERI-AORTIC LYMPH NODES. F. OMENTUM. INTRAOPERATIVE CONSULTATION DIAGNOSIS: FSA-uterus tubes, and ovaries: Endometrial carcinoma, FIGO grade 3 with full thickness myometrium. involvement and extensive necrosis. FSD-right iliac node: Positive for carcinoma in soft tissue. Diagnoses called by Dr to Dr. at. GROSS DESCRIPTION: A. UTERUS, TUBES AND OVARIES. Received fresh labeled with the patient's identification and "uterus, tubes and ovaries" is a distorted. hysterectomy specimen with attached bilateral tubes and ovaries weighing 292 g and measuring 12.5 x. 8.5 x 7.5 cm. The serosa is unremarkable; the anterior surface is inked blue and the posterior surface. black. The ectocervix smooth and glistening and is 2.5 x 1.7 x 0.3 cm. The cervical os is slit-like,. patent, and 0.8 cm. The uterus is bivalved; cervical canal has a trabeculated appearance and the entire. endometrial cavity (4 x 4 cm) is covered by an exophytic mass with a necrotic cut surface. It appears. to involve the full thickness of the myometrium. Fallopian tubes are ligated; right tube is 4.2 cm in. length and a 0.5 cm in diameter and the left tube is 3.3 cm in length and 0.6 cm in diameter. The right. ovary is 3.2 x 1.4 x 0.6 cm and the left is 2.3 x 1.4 x 0.9 cm; they are unremarkable. Photograph is. taken. Representatively submitted: FSA1: frozen section of endomyometrial mass. A2: anterior cervix. A3: posterior cervix. A4-A8: full thickness sections of endo- myometrial mass. A9: right fallopian tube and ovary. A10: left fallopian tube and ovary. B. LEFT PELVIC NODES. Received in formalin labeled with the patient's identification and "left pelvic nodes" is an aggregate. yellow-tan soft tissue, 8.2 x 5.4 x 2.1 cm containing 7 lymph nodes ranging from 0.5 x 0.4 x 0.2 cm to. 6.3 x 1.9 x 1.4 cm. The larger lymph nodes are sectioned and have fatty pink-tan cut surfaces. Lymph. nodes are submitted entirely: B1: 3 lymph nodes. B2-B4: 1 bisected lymph node in each cassette. B4-B8: 1 lymph node, sectioned. C. RIGHT PELVIC NODES. Received in formalin labeled with the patient's identification and "right pelvic nodes" is an aggregate of. yellow-tan soft tissue admixed with friable pink-tan tissue, 8 x 7.5 up to 2.7 cm containing lymph nodes. ranging from 0.4 x 0.4 x 0.2 cm to 3.1 x 2.3 x 2.2 cm. The larger lymph nodes are sectioned and have. friable and necrotic cut surfaces. Lymph nodes are submitted entirely: C1-C2: 3 lymph nodes in each cassette. C3-C4: 1 bisected lymph node in each cassette. C5-C7: 1 lymph node, sectioned. C8: loose friable tissue. D. RIGHT ILIAC NODE. Received fresh labeled with the patient's identification and "right iliac node" is an aggregate of tan soft. tissue, 3.5 x 2 x 0.4 cm. Submitted entirely for frozen section diagnosis in cassette FSD. E. PERIAORTIC NODE. Received in formalin labeled with the patient's identification and "periaortic node" are pieces of yellow-. tan soft tissue in aggregate, 3.5 x 2.4 x 1.1 cm containing two lymph nodes, 0.3 x 0.3 x 0.2 cm and 1.1 x. 0.8 x 0.3 cm; submitted entirely: E1: 2 lymph nodes. E2-E3: remainder of soft tissue. F. OMENTUM. Received in formalin labeled with the patient's identification and "omentum" is a piece of omentum, 27 x. 11.5 x 2.3 cm. Serial sectioning reveals no discrete lesions. Representatively submitted in cassettes. F1-F3. DIAGNOSIS: A. UTERUS, FALLOPIAN TUBES AND OVARIES; HYSTERECTOMY, BILATERAL SALPINGO-. OOPHORECTOMY: - ENDOMETRIAL ADENOCARCINOMA, ENDOMETRIOID TYPE, FIGO 3. WITH. EXTENSIVE NECROSIS, INVOLVING > 50% OF THE MYOMETRIAL. THICKNESS (18/20 MM). - LYMPHATIC INVASION IS SEEN. - CERVIX WITH NO PATHOLOGIC ABNORMALITIES - NO TUMOR SEEN. - OVARIES AND FALLOPIAN TUBES WITH NO PATHOLOGIC ABNORMALITIES. - SEE NOTE. - SEE TEMPLATE. Note: IHC for ER and PR was done. Tumor cells were strongly positive for ER and PR. B. LEFT PELVIC LYMPH NODES; EXCISION: - REACTIVE LYMPH NODES - NO TUMOR SEEN (0/7). C. RIGHT PELVIC LYMPH NODES; EXCISION: - METASTATIC ADENOCARCINOMA to LYMPH NODES, WITH. EXTRACAPSULAR. INVASION (2/6). D. RIGHT ILIAC NODE; EXCISION: - METASTATIC ADENOCARCINOMA TO ONE LYMPH NODE WITH. EXTRACAPSULAR INVASION (1/1). E. PERIAORTIC LYMPH NODES; EXCISION: - REACTIVE LYMPH NODES - NO TUMOR SEEN (0/5). F. OMENTUM, OMENTECTOMY: - FIBROADIPOSE TISSUE - NO TUMOR SEEN. SYNOPTIC REPORT - ENDOMETRIUM. Prior biopsy specimen: Prior case #:: Prior biopsy diagnosis: Adenocarcinoma. Specimen Type: Hysterectomy plus bilateral salpingo-oophorectomy. Tumor Size: Greatest dimension: 4cm. Additional dimensions: 4cm. WHO CLASSIFICATION. Endometrioid adenocarcinoma 8380/3. Histologic Grade: G3: More than 50% nonsquamous solid growth. Myometrial Invasion: Invasion present. Depth of invasion: 18mm. Myometrial thickness: 20mm. Venous/lymphatic invasion: Present. Cervical Involvement: No. Margins: Negative. Lymph nodes: Positive Right pelvic 2/6 Left pelvic 0/7 Paraaortic 0/5. Other tissue removed for staging: Right iliac lymph node 1/1. Additional Findings: None identified. Peritoneal cytology: Negative. Cytology case #: Pathologic stage (pTNM): pT 1c N 1 M X. Comment(s): revised FIGO is IIIC. CLINICAL HISTORY: Endometrial cancer. PRE-OPERATIVE DIAGNOSIS: None given. Microscopic/Diagnostic Dictation: Final Review: PATHOLOGIST,. Final Review: PATHOLOGIST. Final: PATHOLOGIST,.
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TCGA-R6-A6DQ.003A2BE1-B0E1-427B-B44C-655E106F8A4E
|
MODIFIED REPORT - REVIEW ADDENDUM SECTION. DIAGNOSIS. (A) ESOPHAGUS, DISTAL, TUMOR, BIOPSY: INVASIVE MODERATELY TO POORLY DIFFERENTIATED ADENOCARCINOMA. GROSS DESCRIPTION. (A) DISTAL ESOPHAGEAL TUMOR - Multiple fragments of tan-pink soft tissue (1.2 x 0.6 x 0.2 cm). Specimen submitted entirely. in A. CLINICAL HISTORY. Esophageal CA. SNOMED CODES. T-56000, M-81403. "Some tests reported here may have been developed and performance characteristics determined by. These tests have not been. specifically cleared or approved by the U.S. Food and Drug Administration.". Entire report and diagnosis completed by: Start of ADDENDUM. Page: 2. ADDENDUM. This modified report is being issued to report results of immunostain. Addendum completed by. COMMENT. This addendum is issued to report results of immunostain for Her-2/neu performed on distal esophageal. adenocarcinoma. The tumor cells are immunonegative for Her-2/neu (score 0 of 3). Entire report and diagnosis completed by: END OF REPORT-.
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TCGA-DD-AADD.DCDE4D46-AB4E-4C21-9F01-35A304FFF8D5
|
CLINICAL DIAGNOSIS: HCC. Specimen : liver. Gross Photo. GROSS: Specimen status: Fresh. Operation: Right posterior sectionectomy. Organ: Liver, right posterior (15.0 X 10.5 X 8.5 cm, 780.0 gm), (16.0 x 5.0 x 3.5 cm, 75.5 gm). Adrenal gland (5.5 X 2.5 X 0.3 cm). Gallbladder (8.5 cm in length, 4.5 cm in diameter). Lesion: Heaptic mass. Size: 7.5 X 6.6 X 5.1 cm. Cut surface: Encapsulated, pale tan and nodular mass with central necrosis. Gross type: Multinodular confluent. Extent: Confined to the capsule. Resection margin: Not involved, grossly (safety margin: 1.5 cm). Remaining parenchyme: Unremarkable. [Gallbladder]. Serosal surface: Yellowish pink and smooth. Mucosal surface: Dark green and velvety, no mural nodule. Representative sections are submitted. Gross photo: Present. Blocks. T1-6, mass of liver X 6. RM, tumor with resection margin X 1. L, nontumorous liver parenchyme x 1. A1-2 tumor and adjacent adrenal gland X 2. B1-2, liver parenchyma X 2. GB, gallbladder x 1. MICROSCOPIC: Tumor type: Hepatocellular carcinoma. Edmondson-steiner grade. The worst differentiation IV. The major differentiation III. Histologic type: Cord-like and nesting. Fatty change: No. Fibrous capsule formation: Yes. Capsular infiltration: Yes, focal. Septum formation: Yes. Surgical resection margin invasion: No. Serosal invasion: No. Portal vein invasion: Not identified. Vascular invasion: No. Bile duct invasion: No. Remaining liver parenchyme: Chronic hepatitis, HBV associated. NOT reported. Gross: liver,ectomy,Hepatocellular carcinoma. T56000, P10, M81703. adrenal gland,ectomy,no tumor. T93000, P10, M09450. gallbladder,ectomy,autolysis. T57000, P10, M54001. DIAGNOSIS: Liver, right posterior, sectionectomy: Hepatocellular carcinoma. Adrenal gland, right, adrenalectomy: No tumor present. Gallbladder, cholecystectomy: Autolysis. Suggestion :
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TCGA-CZ-4856.7b616a12-9d64-4671-8369-815dcbacc3cb
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Report Status. Type: Surgical Pathology. Specimen Type: Kidney, partial or total resection. Procedure Date: Resident : Pathologi. PATHOLOGIC DIAGNOSIS: LEFT KIDNEY, NEPHRECTOMY (210.5g) : RENAL CELL CARCINOMA,/ clear cell type, 4.2 cm, involving lower pole, Fuhrman. nuclear grade II (of IV). Tumor is confined to the kidney. Soft tissue margin of resection is negative for tumor. Renal vein, renal artery, and ureteral margins are negative for tumor. No lymphovascular invasion present. AJCC Stage (6th edition) : Tlb NO MX. REGIONAL LYMPH NODES, BIOPSY: Four lymph nodes with no tumor present. EVALUATION OF NON-NEOPLASTIC KIDNEY (NEPHRECTOMY SPECIMEN) : KIDNEY WITH MINOR, NON-SPECIFIC ABNORMALITIES, INCLUDING MILD FOCAL GLOBAL. GLOMERULOSCLEROSIS (4% OF TOTAL GLOMERULI). ARTERIAL AND ARTERIOLAR SCLEROSIS, MILD TO MODERATE. MICROSCOPIC DESCRIPTION. The sample consists of kidney cortex and medulla. There are up to one. hundred ninety six (196) glomeruli present in the sample submitted for light. microscopy. Eight (8) glomeruli are globally obsolescent (sclerosed). The. preserved glomeruli show normal cellularity and reveal no significant. pathological changes. Very mild mesangial expansion and occasional reabsorption. granules are recognized. On PAS and. silver methenamine stain, the. glomerular basement membranes appear of normal thickness. Tubules are well. preserved; occasional tubules are mildly distended and show few hyaline casts. The interstitium shows minimal fibrosis and mononuclear inflammation. Less than. 5% of the sample shows tubular atrophy and interstitial fibrosis, as evidenced. on the trichrome stains (AFOG) Arteries and arterioles reveal mils to. moderate sclerosis of the wall, with focal hyalinosis and mild signs of. vasoconstriction in the arteriolar walls. The non-neoplastic kidney was evaluated by. Renal Pathology. CLINICAL DATA: History: with incidental finding of (L) renal mass. Operation: Not specified. Operative Findings: None given. Clinical Diagnosis: Not provided. TISSUE SUBMITTED. A/1. (L) kidney - FS. B/2. Regional nodes. GROSS DESCRIPTION: The specimen is received fresh, in two parts, each labeled with the patient?s. name and unit number. Part A, received fresh in the frozen section lab, labeled "#1. (L) kidney -. FS", consists of a left `nephrectomy specimen (210.5 gm; 11.7 x 6.5 x 4.8 cm). to. include ureter (6.8 cm in length x 0.3 cm in diameter). renal veins (1.4 cm in. length x 0.5 cm in diameter each) renal artery (2.3 cm in length x 0.4 cm in. diameter), and scant loosely attached perinephric fat (7.2 x 5:2 "Cm. predominately at the lower pole) - The specimen is inked black and bivalved,. revealing a golden yellow, focally hemorrhagic, predominately solid. encapsulated mass (4. 2 x 3.5 x 3.9 cm) within the lower pole, 4.5 cm from the. ureter, 1.6 cm from the nearest renal vein margin, and 2.6 cm from the renal. artery margin. The mass grossly abuts the renal capsule but does not appear to. invade through the capsule into the perinephric fat. Representative sections. of the mass are submitted to the tissue bank, cytogenetics; and electron. microscopy for special studies. Representative normal cortex is held for. future electron microscopy, immunofluorescence, and tissue banking studies. The renal pelvis displays unremarkable tan/white glistening urothelium. The. cortical medullary junction is well-demarcated with no other gross lesions. identified. No lymph nodes are identified within the scant perihilar or. perinephric fat. The adrenal gland is not identified. Photographs are taken. Micro A1: Ureteral, renal vein, and renal artery margins, (en face), 4. frags total,. Micro A2: "Tl" (tumor quick-fix), 1 frag,. Micro. A3-A4: Deepest extension of mass in relationship to perinephric fat and. capsule, 2 frags,. Micro A5: Focally cystic component of mass to include areas of hemorrhage,. 1 frag,. Micro A6: Mass in relationship to pelvis, 1 frag,. Micro A7: Mass in relationship to adjacent uninvolved parenchyma, 1 frag,. Micro A8: Cortical medullary junction, 1 frag,. Part B, labeled "#2. Regional nodes", consists of a 3.6 x 2.2 x 0.6 cm. aggregate of yellow/tar lobulated fat, within which four tan rubbery lymph node. candidates (ranging from 0.2 cm up to 1.1 cm in greatest dimension) are. identified. Micro B1: 2 single whole lymph node candidates, 2 frags,. Micro B2: 2 single whole lymph node candidates, 2 frags,. By his/her signature below, the senior physician certifies that he/she. personally conducted a microscopic examination ("gross only" exam if so stated). of the described specimen (s) and rendered or confirmed the diagnosis (es). related thereto. Resident Review by. Final Diagnosis by. Type: Cytogenetics. Cytogeneticist. KARYOTYPE: 45,XX,der (3) t (3 ;14) (p1?4;q2?1), ins (4;5) (q?31;q2?3q3?2), -14. METAPHASES COUNTED: 15. ANALYZED: 8. SCORED: 7. BANDING: GTG. INTERPRETATION: All metaphases contained clonal aberrations that included 3p deletion, which is. a characteristic finding in renal cell carcinoma, clear cell type. COMMENTS: Mosaicism and small chromosome anomalies may not be detectable using the. standard methods employed. Chromosome analysis was performed at a level of 400. bands or greater. INDICATION FOR TEST: ?RCC. REPORT by. Final Diadnosis wy. tectronically signed on.
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TCGA-2Y-A9H2.4C19CF84-5E30-4854-A084-F6EE53A80543
|
Final Diagnosis. A. LIVER, LEFT LATERAL SEGMENT 3, EXCISIONAL BIOPSY: Bile duct hamartoma. B. LIVER, LEFT LATERAL SEGMENT, EXCISION: Benign hepatic parenchyma, negative for carcinoma. C. LYMPH NODE, PERIPORTAL ADENOPATHY: One lymph node free of malignancy (0/1). D. LIVER AND GALLBLADDER, LIVER SEGMENTS 4B AND 5, HEPATIC SEGMENTECTOMY. AND CHOLECYSTECTOMY: Hepatocellular carcinoma, poorly differentiated, with sclerotic stroma. Carcinoma invades into the subserosa of the gallbladder. Perineural invasion identified. No lymphatic or venous invasion identified. Hepatic parenchymal margin is free of malignancy, see Key Pathological Findings. I,. the attending pathologist, personally reviewed the. entire case and rendered the final diagnosis. Electronically signed Out by. Key Pathological Findings. D: Liver, Resection, Synoptic Data. SPECIMEN TYPE: 48 AND 5 SEGMENTECTOMY. FOCALITY: Solitary (specify location): segment 4b and 5. TUMOR SIZE: 3.4 cm. HISTOLOGIC TYPE: Hepatocellular carcinoma. HISTOLOGIC GRADE: GIII: Poorly differentiated. PRIMARY TUMOR (pT): pT1: Solitary tumor with no vascular invasion. REGIONAL LYMPH NODES (pN): pNO: No regional lymph node metastasis. Number examined: 1. Number involved: 0. DISTANT METASTASIS (pM): pMX: Cannot be assessed. MARGINS: Parenchymal margin uninvolved by invasive carcinoma. Bile duct margin cannot be assessed. VENOUS (LARGE VESSEL) INVASION (V): Absent. ADDITIONAL PATHOLOGIC FINDINGS: None identified. Specimen(s) Received. A. LEFT LATERAL SEGMENT 3 EXCISIONAL BX OF LIVER FS. B. LEFT LATERAL SEGMENT 2 NODULE FS. C. PERIPORTAL ADENOPATHY FS. D. LIVER SEGMENT 4B AND 5 AND GALLBLADDER - GROSS EXAM. Clinical History. HCC. Preoperative Diagnosis. Hepatocellular carcinoma. Frozen Section Diagnosis. FSA1 LEFT LATERAL SEGMENT 3: Bile duct hamartoma. FSB1. LEFT LATERAL SEGMENT 2 NODULE: Negative for carcinoma. FSC1 PERIPORTAL ADENOPATHY: Reactive lymph node. No evidence of malignancy. Comment: This frozen section diagnosis/result was communicated to and acknowledged by. in. at. per. Intraoperative Consultation. D. LIVER AND GALLBLADDER: Lesion grossly measures 1.1 cm from parenchymal margin. Gross Description. A. Specimen A is received fresh for frozen section labeled "left lateral segment 3 excisional. biopsy." The specimen consists of a 1.5 x 1.0 x 0.5-cm, tan-gray, soft tissue, which is entirely. submitted for frozen section labeled FSA1. B. Specimen B is received fresh for frozen section labeled left lateral segment 2 nodule. The. specimen consists of a 1.2 x 0.3 x 0.2-cm, tan-gray, soft tissue, which is entirely submitted for frozen. section labeled FSB1. C. Specimen C is received fresh for frozen section labeled "periportal adenopathy." The. specimen consists of a 1.8-cm lymph node with a small amount of attached fat. The lymph node is. bisected and entirely submitted for frozen section labeled FSC1. D. Specimen D is received fresh labeled "liver segment 4B and 5, and gallbladder." The. specimen consists of a 116-g, 8.6 x 5.1 x 4.3-cm wedge of liver with an adherent 8.7 x 3.3 x 2.2-cm. gallbladder. The capsule is indurated surrounding the adherent gallbladder with a small amount of. attached fat. Sectioning through the liver at the adherent gallbladder reveals a circumscribed, 3.4 x. 2.7 x 2.4-cm, gray-white tumor, which extends to the overlying capsule to the soft tissue surrounding. the gallbladder. No extension into the gallbladder wall is identified. The tumor is 1.1 cm from the. parenchymal margin. The surrounding parenchyma is dense, tan-brown. On opening the gallbladder,. the lumen contains a small amount of viscous, green-black bile. The mucosal surface is granular,. tan-green, and the wall measures 0.1 cm in thickness. The fat adjacent to the neck of the neck of. the. gallbladder is focally indurated. The medial parenchymal margin is inked red, fateral yellow, superior. blue, and deep black. The fat attached to the liver capsule is inked green. Representative sections. are submitted labeled. D1-3: Tumor to adherent gallbladder. D4: Tumor to closest parenchymal margin. D5: Tumor to adherent fat. D6: Lumen at parenchymal margin. D7: Tumor to capsule and adjacent parenchyma. D8: Gallbladder, cystic duct margin. D9: Fat attached to gallbladder neck. D10-11: Fat attached to liver capsule. Tissue from specimen D is submitted to tissue procurement laboratory.
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TCGA-CN-5356.92475b34-d426-496c-b41d-932a3f8ed65f
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Report Type. PATIENT HISTORY : CHIEF COMPLAINT/ PRE-OP/ POST-OP DIAGNOSIS: Malignant neoplasm of. larynx. PROCEDURE: Laryngectomy. SPECIFIC CLINICAL QUESTION Not given. OUTSIDE TISSUE DIAGNOSIS: Not given. PRIOR MALIGNANCY: Not given. CHEMORADIATION THERAPY : Not given. ORGAN TRANSPLANT: Not given. IMMUNOSUPPRESSION Not given. DISEASES: Not given. FINAL DIAGNOSIS: PART 1: LYMPH NODES, RIGHT, LEVEL 2, 3 AND 4, NECK DISSECTION. SIXTY-ONE BENIGN LYMPH NODES. PART 2: LYMPH NODES, LEFT, LEVEL 2, 3 AND 4, NECK DISSECTION. THIRTY-SIX BENIGN LYMPH NODES. PART 3: LARYNX AND THYROID GLAND, TOTAL LARYNGECTOMY AND RIGHT THYROID. LOBECTOMY. A. INVASIVE, MODERATELY DIFFERENTIATED SQUAMOUS CELL CARCINOMA. OF THE. SUPRAGLOTTIC REGION PREDOMINANTLY ON THE RIGHT SIDE AND WITH INVASION. OF THE. PRE-EPIGLOTTIC SPACE, 4.5 CM. B. TUMOR ASSOCIATED ACUTE ABCESS FORMATION. C. MARGINS FREE OF TUMOR. D. NO PERINEURAL INVASION SEEN. E. PRESENCE OF A TRACHEOSTOMY. F. RIGHT THYROID LOBE WITH FOCAL FIBROSIS. G. pT3 NO MX. PART 4: LARYNX, RIGHT LATERAL MARGIN. NO TUMOR SEEN. PART 5: LARYNX, LEFT LATERAL MARGIN. NO TUMOR SEEN. PART 6: LARYNX, INFERIOR MARGIN. NO TUMOR SEEN. PART 7: LARYNX, RIGHT SUPERIOR MARGIN. NO TUMOR SEEN. PART 8: LARYNX, LEFT SUPERIOR MARGIN. O TUMOR SEEN. My si. station that I have personally reviewed the. submitted. material (s) and the final diagnosis reflects that evaluation. GROSS DESCRIPTION: The specimen is received fresh in eight parts. Part 1 is labeled with the patient's name, initials, xx, and "right. neck. levels 2, 3, and 4". The specimen is received unoriented and measures. 14.0 X. 5.5 X 3.0 cm. It contains nodules ranging from 0.4 to 3.2 cm. All the. nodules are submitted. Cassette code. 1A 1J nodules from the first third. 1A one lymph node, 3.2 cm. 1B one lymph node, 2.2 cm. 1C one lymph node, 2.0 cm. 1D 1E one lymph node, 2.8 cm. 1F 1J multiple lymph nodes. 1K. 1N lymph nodes from second third. 1K one lymph node, 2.0 cm. 1L 1N multiple lymph nodes. 10. 1T multiple lymph nodes from last third. 10 one lymph node, 2.8 cm. 1P 1T multiple lymph nodes. Part 2 is labeled with the patient's name, initials, xx, and "left neck. levels. 2, 3, and 4". The specimen is received unoriented and measures 13.0 X. 5.4 X. 2.5 cm. It contains nodules ranging from 0.4 to 2.0 cm. All the nodules. found. are submitted. Cassette code: 2A 2B one lymph node, 2.0 cm, from first third. 2C 2D multiple lymph nodes from first third. 2E 2H multiple lymph nodes from second third. 2I. 2L multiple lymph nodes from last third. Part 3 is received labeled with the patient's name, initials, xx, and. "larynx". It measures 10.0 cm (SI) X 9.0 (L) X 6.5 (AP) Skin is. present on. the anterior side with a central opening that is communicating with the. trachea. The right and left supraglottic region and almost the entire. epiglottis are involved by a white-gray, firm lesion of 4.5 (SI) X 2.5. (L) X. 2.2 (AP) This lesion is at 0.2 cm from the right anterior margin, at. 0.3 cm. from the right lateral margin, at 5.0 cm from the trachea, 0.8 cm from. the. left lateral margin and at 0.9 cm from the left anterior margin. A 4.5. X 2.5. X 1.5 cm right thyroid lobe is also present. Its parenchyma is red,. homogeneous and does not contain any lesions. Digital images are taken. Cassette code: 3A shave trachea margin. 3B shave left anterior margin. 3C shave then perpendicular right anterior margin. 3D 3H right larynx, full section (D epiglottis upper, 3E epiglottis. lower,. 3F vocal cords, 3G soft tissue anterior to vocal cords, 3H inferior). 3I 3J lateral right margin. 3K right thyroid lobe, representative section. 3L 30 left larynx full section (3L epiglottis superior, 3M. epiglottis. lower, 3N vocal cords, 30 inferior section). 3P left lateral margin,. 3Q lymph node? left anterior soft tissue. Part 4 is labeled with the patient's name, initials, xx, and "right. lateral. margin, stitch superior". It consists of a tan-pink fragment of 6.0. X. 0.5 X. 0.2 cm. The side identified by a stitch is inked blue. The specimen is. submitted totally in cassette labeled 4AFS. Part 5 is labeled with the patient's name, initials, XX and "left. lateral. margin". It consists of a tan-pink fragment, 4.3 X 0.2 X 0.3 cm. A. clip. identifies the superior side and this region is inked blue. The. specimen is. totally submitted in cassette labeled 5AFS. Part 6 is labeled with the patient's name, initials, XX and "inferior. margin". The tan-pink fragment is 2.5 X 0.5 X 0.2 cm. The right side is. identified by. a clip and this region is inked blue. The specimen is totally submitted. in. cassette labeled 6AFS. Part 7 is labeled with the patient's name, initials, XX and "right. superior. margin". It consists of two fragments of tan-pink tissue measuring 1.1. X 0.5. X 0.3 and 1.7 X 0.3 X 0.3 cm. The right side is identified by double. clips. and one clip identifies external margin. These regions are inked blue. The. specimen is totally submitted in a cassette labeled 7AFS. Part 8 is labeled with the patient's name, initials, XX and "left. superior". It consists of pink to tan fragment, 3.5 X 0.4 X 0.2 cm. A clip. identifies the. left side and this region is inked blue. The specimen is totally. submitted in. RAOPERATIVE CONSULTATION: 4AFS : RIGHT LATERAL MARGIN (frozen section). A. BENIGN. B. NO TUMOR SEEN. 5AFS: LEFT LATERAL. n section). A. BENIGN. B. NO TUMOR SEEN. 6AFS. INFERIOR MAR. tion). A. BENIGN. B. NO TUMOR SEEN. 7AFS: RIGHT SUPERI. en section). A. BENIGN. B. NO TUMOR SEEN. 8AFS : LEFT SUPERIO. section). A. BENIGN. NO TUMOR SEEN. COPIC: Microscopic examination substantiates the above diagnosis. One H&E. recut. was performed on 3F. The following statement applies to all immunohistochemistry, Insitu. Hybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and. Immunofluorescent Testing: The testing was developed and its performance characteristics. dete. the. Department of Pathology, as required by. regulations. The testing has not been cleared or approved for the. S. cific use by the U.S. Food and Drug Administration, but the FDA has. determined such approval is not necessary for clinical use. Tissue. fixation. ranges from a minimum of 2 to a maximum of 84 hours. This laborator. certified under the Clinical Laboratory Improvement. Amendments of. ("CLIA") as qualified to perform high-complexity. clinical. testing. Pursuant to the requirements of CLIA, ASR's used in this. laboratory. have been established and verified for accuracy and precision. Additional. information about this type of test is available upon request. CASE SYNOPSIS: SYNOPTIC DATA - LARYNX RESECTIONS. TYPE OF LARYNGECTOMY : Total. TUMOR LATERALITY: Bilateral. ATTACHED STRUCTURES: Tracheotomy, Thyroid, Skin. TUMOR LOCATION/SEGMENT: Supraglottic. TUMOR SIZE: Maximum dimension: 4.5 cm. HISTOLOGIC TYPE OF TUMOR: Squamous cell carcinoma. HISTOLOGIC GRADE: Moderately differentiated. STRUCTURES INVOLVED BY TUMOR: False cord, Epiglottis, Pre-. epiglottic. space. LYMPH NODES: Lymph nodes positive, Right: 0. Total number of right sided lymph nodes examined: 61. Lymph nodes positive, Left: 0. Total number of left sided lymph nodes examined: 36. EXTRACAPSULAR SPREAD OF LYMPH NODE METASTASES. INTRA-PERINEURAL INVASION: Absent. VASCULAR INVASION: SURGICAL MARGIN INVOLVEMENT: Free (2 mm or more). T STAGE, PATHOLOGIC: Supraglottis, pT3. N STAGE, PATHOLOGIC: pNO. M STAGE, PATHOLOGIC: pMX. HISTO TISSUE SUMMARY/SLIDES REVIEWED: Part 1: ck Level 2,3, and 4. 00:00. 07:49. Stain/c. ock. H&E X 1. A. H&E X 1. B. H&E X 1. C. H&E X 1. D. H&E X 1. E. H&E X 1. F. H&E X 1. G. H&E X 1. H. H&E X 1. H&E X 1. H&E X 1. K. H&E X 1. L. H&E X 1. M. H&E X 1. N. H&E X 1. O. H&E X 1. P. H&E X 1. Q. H&E X 1. R. H&E X 1. S. H&E X 1. Part 2 : ls 2,3, and 4. Taken: : Stain/ C11. H&E X 1. A. H&E X 1. B. H&E X 1. C. H&E X 1. D. H&E X 1. E. H&E X 1. F. H&E X 1. G. H&E X 1. H. H&E X 1. H&E X 1. H&E X 1. K. H&E X 1. L. H&E X 1. M. H&E X 1. N. H&E X 1. O. Part 3 : 00:00. Stain/ CTTC. ock. H&E X 1. A. H&E X 1. B. H&E X 1. C. H&E X 1. D. H&E X 1. E. H&E X 1. G. H&E X 1. H. H&E X 1. H&E X 1. H&E X 1. K. H&E X 1. H&E X 1. M. H&E X 1. O. H&E X 1. P. H&E X 1. Q. H&E X 1. R. H&E X 1. S. H&E Recut X. 1. FDC. H&E X 1. FDC. H&E X 1. NDC. Margi. H&E X 1. AFS. argin. H&E X 1. AFS. n Cli. H&E X 1. AFS. Marg. p Far Right. H&E X 1. AFS. Margi. H&E X 1. AFS. TC1.
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TCGA-HS-A5N8.23C57E99-5BF2-4CD2-AC62-E58D3FBBF273
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Sample Type TUMOUR. Diagnosis. Leiomyosarcoma. Year of Sample Collection. Age at Sample Collection (yrs). Days to Procedure Date. Days to Diagnosis. Type of Procedure. RESECT. Site of Tissue/Primary (Histology). Uterus, Ovary. Tumour Size (cm). 10. Histology. Leiomyosarcoma. Grade/Differentiation. X. Pathological T. T2b. Pathological N. NX. Clinical M. M0. Histology Comments. Sample Type BUFFY. Year of Sample Collection. Age at Sample Collection (yrs). Days to Procedure Date. Days to Diagnosis.
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TCGA-D5-6923.3523f7ac-0a52-44cb-9b99-068955ccb1da
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page 1 / 1. copy No. 2. Examination: Histopathological examination. Cost of diagnostic procedure. Material: Multiple organ resection - segment of the large intestine. Expected time of examination: Clinical diagnosis: Cancer of the sigmoid colon. Macroscopic description: A 12 cm length of the large intestine with fat tissue sized 14 X 6 x 9.5 cm. Tumour sized 4 X 3 X 1.5 cm detected. in the mucosa. The lesion surrounding 50% of the intestine circumference, removed by 5 cm from one of the. incision lines, and 5.3 from the opposite one. The lesion infiltrates macroscopically the muscular membrane. Diverticulum 1 cm in diameter found outside the tumour. Microscopic description: Adenocarcinoma tubulopapillare (G2). Infiltratio carcinomatosa profunda tunicae muscularis propriae . Incision. lines free of neoplastic lesions. Lymphonodulitis reactiva (No XI). Histopathological Diagnosis: Adenocarcinoma tubulopapillare coli. Tubulopapillar adenocarcinoma of the colon. (G2, Dukes B, Astler - Coller Bl, pT2, pNO). CONTACT YOU DOCTOR WITH THIS REPORT!.
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TCGA-AG-3731.0c404036-04f3-45c0-a319-48203d8a380e
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Diagnosis/diagnoses: Rectal resection material shows a moderately differentiated adenocarcinoma (G2) located. in the distal rectum, with superficial infiltration of the perirectal fatty tissue (pT3) and. tumor-free oral, aboral and perirectal resection margins. Follow-up report: Following acetone clarification, 34 lymph nodes in the pericolic fatty tissue bordering the. tumor were prepared, measuring up to 1.2 cm. Amongst these, three metastatic infiltrations of the previously diagnosed adenocarcinoma. and colon carcinoma were identified. In conclusion and in summary a stage of pT3 pN1 (3/34) is established.
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TCGA-A8-A08B.2261B407-340D-4BB3-94BC-F06096FBDA80
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Diagnosis: 1. Bifocal poorly differentiated invasive ductal carcinoma (tumor diameters: 2.5. cm and 0.7 cm) with focal intraductal components. Concluding tumor classification: NOS, G III, pT2(mult)NO(sn)LOVORO.
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TCGA-EA-A3HR.BE99BE0C-3FB8-4AE6-B66D-977B858D880E
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Laterality: Path Report:CERVIX TISSUE CHECKLIST. Specimen type: Hysterectomy, bilateral salpingo-oophorectomy. Tumor site: Cervix. Tumor size: 1 X 0.8 x 0.5 cm. Histologic type: Squamous cell carcinoma. Histologic grade: Moderately differentiated. Tumor extent: Lesion less than 4.0 cm. Lymph nodes: Not specified. Lymphatic invasion: Not specified. Venous invasion: Not specified. Margins: Not specified. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified. Comments: None. Gross Description: Microscopic Description: Diagnosis Details:
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TCGA-RT-A6YA.8E4AD039-1F25-4A60-AEA2-E090EAF79C44
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Patient Info. Specimen #: FINAL DIAGNOSIS. 1. Left adrenal gland, laparoscopic adrenalectomy (A) - Pheochromocytoma. (15.0 cm in greatest dimension). - The inked surgical margin of resection is negative for tumor. (See. comment). 2. Left peri-adrenal soft tissue, excision (B) - Pheochromocytoma invading. large vein wall. - Fibroadipose tissue negative for tumor. (See comment). COMMENT. 1. The tumor shows capsular invasion as well as involvement of the. peri-adrenal soft tissue. Nuclear pleomorphism is identified. Vascular. invasion is present (part B). Mitoses are up to 4 per 10 high-power fields. The Pheochromocytoma of the Adrenal gland Scaled Score (PASS) for the tumor. is 7. Tumors with a PASS 4 have an increased propensity to behave in a. malignant fashion. Clinical follow up is advised. This case has been reviewed in intradepartmental consultation by. who agree with the above interpretation. (Electronic Signature). SPECIMEN SUBMITTED. A: LEFT PHEOCHROMOCYTOMA. B: PERI-ADRENAL SOFT TISSUE. CLINICAL DATA. BENIGN NEOPLASM OF ADRENAL GLAND. GROSS DESCRIPTION. A. Received fresh labeled "left pheochromocytoma" the specimen consists of. an ovoid tissue mass with attached fibroadipose tissue measuring 15.0 x. 14.5 x 7.6 cm, and weighing 245.7 grams. The mass appears well. encapsulated, rubbery, and pink-tan. Cross section reveals a sharply. circumscribed tumor mass measuring 14.8 cm in greatest dimensions with a. slightly bulging cut surface. Cystic spaces are present and measure up to. 6.9 cm in greatest diameter. Representative sections are submitted in. formalin in eight cassettes. Additional tissue with mass and inked line of. resection are submitted in cassettes A9-A11. B. Received fresh labeled "peri-adrenal soft tissue" are multiple irregular. yellow-red segments of fibroadipose tissue aggregating to 4.2 x 4.0 x 1.5. cm. Upon sectioning, a fibrous region is identified. Representative. sections are submitted in formalin in two cassettes. Submitted by: Test performed by: Lab and Collection. Lab and Collection Information. Result History. der Result History Report,. Result Date and Time. Provider Status. This result is currently not released to. Display Full Result Report. Display Order Report.
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TCGA-06-0237.29763612-8827-45e2-90c1-c69e0d5b18cb
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CLINICAL HISTORY. with recent onset seizure has a right frontal. meningiomaand a right temporal intra axial enhancing lesion. OPERATIVE DIAGNOSES. Not Given. Operation/Specimen: A: Brain tumor. B: Brain tumor. PATHOLOGICAL DIAGNOSIS: A and B. Brain, right temporal, excisional biopsies: Glioblastoma. See Comment. COMMENT. In parts A and B there is an astrocytic neoplastic proliferation that. diffusely infiltrates and focally effaces the brain parenchyma. The neoplasm. has nuclear anaplasia, frequent multinucleated cells, mitoses, and. microvascular cellular proliferation. Special stains to better characterize the neoplasm are being requested and. will be reported as an addendum. PROCEDURES/ADDENDI. Tmmunohistoloay. Interpretation. Brain, immunohistochemistry: MIB-1 proliferation index 28%. See Results and Comment. Results-Comments. IMMUNOHISTOCHEMISTRY: The GFAP depicts sparse liofibrilogenesis by the. neoplastic cells. The synaptophysin and NFP demonstrate a tenuous positive. background, indicating the infiltrative character of the neoplasm. The Neu N. demonstrates few small neurons entrapped by the neoplasm. More than 50% of. the neoplastic cells over express the p53 protein, and about 28% of the cells. are in the mitotic cycle as depicted by the MIB-1. Comment: The immunophenotype is that of a high histological grade (WHO IV/IV). glial neoplasm, i.e. a glioblastoma. INTRA-OPERATIVE CONSULTATION. A. Brain tumor, imprints and smears: Glioblastoma. GROSS DESCRIPTION. A. Received fresh, several fragments, 0.6 cm. in aggregate. Semi firm,. tannish-yellow and glistening. In total, A1-A2. B. SPECIMEN: Brain tumor permanent. FIXATIVE: Formalin. GENERAL: A 1. 4 x 1.0 x 0.8 cm, 0.32 gm aggregate of several irregularly. shaped red-gray-tan fragments. SECTIONS: B1 all submitted. ICD-9(s) : 191.2 191 2. Histo Data. Part A: Brain tumor. Stain/cnt. Block. Comment. ChromA-DA X 1. 1. mGFAP-DA X 1. 1. H/E x 1. 1. MIB1-DA x 1. NF2F11 X 1. 1. P53D07 X 1. 1. Synap-DA x 1. 1. H/E x 1. 2. Part B: Brain tumor. Stain/cnt. Block. Comment. ChromA-DA X 1. 1. H/E x 1. 1. NF2F11 X 1. 1. Synap-DA x 1. 1.
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TCGA-B6-A401.D76CF03A-54CD-4769-87AA-466473F41FC7
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AP Surgical Pathology: Additional Info. CLINICAL HISTORY: Not provided. GROSS EXAMINATION: A. "Sentinel node #1, hot (AF1-3) ", received for frozen section are three. lymph node candidates. One lymph node is bisected and submitted for frozen. section as AF1-AF2, and the remnant sections are submitted in blocks A1-2. Two additional lymph nodes are submitted for frozen section as AF3, and the. remnant is submitted as block A3. B. "Axillary fat", received in formalin is a 11.3 x 4 x 1.5 cm fragment of. yellow-tan adipose tissue which is dissected to reveal one lymph node. candidate measuring 0.8 x 0.7 x 0.5 cm, which is submitted entirely in block. B1. C. "Left breast cancer, two clips medial, one clip inferior, long stitch. lateral, short stitch superior", received in formalin is a 8 cm medial to. lateral, 7 cm superior to inferior, 2.7 cm anterior to posterior lumpectomy. specimen inked as follows: superior-yellow, inferior-red, anterior-blue and. posterior-black. The specimen is sectioned from medial to lateral to reveal a. 2.0 x 1.5 x 1 cm mass lesion located 0.4 cm from the posterior margin, 0.7 cm. from the anterior margin, 2.7 cm from the medial margin, 2.7 cm from the. lateral margin, 1.3 cm from the superior margin and 3.2 cm from the superior. margin. The remainder of the breast tissue demonstrates fibrofatty lobulated. adipose tissue that is otherwise grossly unremarkable. Sections are submitted. as follows per the block diagram: BLOCK SUMMARY: C1-. medial edge. C2-4. representative medial breast. C5-28 mass submitted entirely. C29-31 representative lateral breast. C32-34 lateral edge. D. "Superior medial margin", received in formalin is a 7.2 x 6.4 x 2.3 cm. fragment of adipose tissue with a stitch marking final margin. The final. margin is inked blue and the opposite margin is inked black. Every other. section is submitted in blocks D1-10. E. "Medial and superior margin", received in formalin is a 5.5 x 3.5 x 2.2 cm. fragment of yellow-tan adipose tissue with a stitch in place marking the final. margin. The stitched margin is inked blue, and the opposite margin is inked. black. The specimen is sectioned to reveal no focal lesions. Every other. section is submitted in blocks E1-12. F. "Inferior to lateral margin", received in formalin is a 6.5 x 5.2 x 2.1 cm. fragment of yellow-tan adipose tissue with a suture marking the final. margin. The final margin is inked blue and the opposite margin is inked. black. The specimen is sectioned to reveal no focal lesions. Every other. section is submitted in blocks F1-11. G. "Anterior skin", received in formalin is a 7.5 x 5 x 2 cm unoriented. aggregate of brown skin with subcutaneous tissue that is grossly. unremarkable. Representative sections are submitted in blocks G1-3. INTRA OPERATIVE CONSULTATION: A. "Sentinel node #1, hot and blue": AF1-2 (one lymph node candidate, bisected) -positive for carcinoma. AF3 (two lymph node candidates) -negative for malignancy. MICROSCOPIC EXAMINATION: Microscopic examination is performed. PATHOLOGIC STAGE: PROCEDURE: Partial mastectomy, sentinel lymph node biopsy. PATHOLOGIC STAGE (AJCC. Edition) : pT1c pN1a (sn) pMX. NOTE: Information on pathology stage and the operative procedure is. transmitted to this Institution's Cancer Registry as required for. accreditation by the Commission on Cancer. Pathology stage is based solely. upon the current tissue specimen being evaluated, and does not incorporate. information on any specimens submitted separately to our Cytology section,. past pathology information, imaging studies, or clinical or operative. findings. Pathology stage is only a component to be considered in determining. the clinical stage, and should not be confused with nor substituted for it. The exact operative procedure is available in the surgeon's operative report. DIAGNOSIS: A. "SENTINEL LYMPH NODE #1" (BIOPSY) : METASTATIC ADENOCARCINOMA IN ONE OF THREE LYMPH NODES (1/3). SIZE OF METASTASIS: 5 MILLIMETERS. EXTRANODAL INVASION: ABSENT. B. "AXILLARY FAT" (EXCISION) : ONE LYMPH NODE, NO EVIDENCE OF MALIGNANCY (0/1) . SEE COMMENT. COMMENT: The specimen is re-examined and only one lymph node is identified. C. "LEFT BREAST CANCER" (PARTIAL MASTECTOMY) : INVASIVE ADENOCARCINOMA OF THE BREAST. HISTOLOGIC TYPE: DUCTAL. NOTTINGHAM COMBINED HISTOLOGIC GRADE: 3 OF 3. TUBULE FORMATION SCORE: 3. NUCLEAR PLEOMORPHISM SCORE: 3. MITOTIC RATE SCORE: 2. GROSS TUMOR SIZE: 2 x 1.5 X 1 CM. SIZE OF INVASIVE COMPONENT: 2.0 CM. LYMPHATIC/VASCULAR INVASION: ABSENT. MULTIFOCAL TUMOR: ABSENT. IN-SITU CARCINOMA: PRESENT. TYPE OF IN-SITU CARCINOMA: CRIBRIFORM. NUCLEAR GRADE OF IN-SITU CARCINOMA: 3 OF 3. NECROSIS: ABSENT. DCIS EXTENDING OUTSIDE INVASIVE TUMOR MASS: ABSENT. SIZE OF IN-SITU CARCINOMA: NOT APPLICABLE. STATUS OF NON-NEOPLASTIC BREAST TISSUE: INTRADUCTAL PAPILLOMA, RECENT. NEEDLE CORE BIOPSY SITE. SIZE OF BIOPSY: 8 X 7 x 2.7 CM. MICROCALCIFICATIONS: ABSENT. SURGICAL MARGIN STATUS: NEGATIVE (GREATER THAN 2 MM) . ESTROGEN/PROGESTERONE RECEPTOR, CELL CYCLE, EGFR AND HER2/NEU ANALYSIS: PENDING. PARAFFIN BLOCK NUMBER: C14. RESULTS WILL BE ISSUED IN SEPARATE REPORT FROM. D. "SUPERIOR MEDIAL MARGIN, LEFT BREAST" (RE-EXCISION) : BREAST TISSUE, NO EVIDENCE OF MALIGNANCY. FINAL MARGIN FREE OF TUMOR. E. "MEDIAL AND SUPERIOR MARGIN, LEFT BREAST" (RE-EXCISION). BREAST TISSUE, NO EVIDENCE OF MALIGNANCY. FINAL MARGIN FREE OF TUMOR. F. "INFERIOR TO LATERAL" (RE-EXCISION) : BREAST TISSUE, NO EVIDENCE OF MALIGNANCY. FINAL MARGIN FREE OF TUMOR. G. "ANTERIOR SKIN" (BIOPSY) : SKIN AND SUBCUTANEOUS TISSUE, NO EVIDENCE OF MALIGNANCY. FINAL MARGIN IS NEGATIVE FOR MALIGNANCY. I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es) . ADDENDUM 1: Please see. for results of supplementary. tests. I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es) .
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TCGA-D5-6926.e5257ac1-cda4-460e-8959-bc4f221e2c6e
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page 1 / 1. copy No. 5. Examination: Histopathological examination. Material: 1. Total organ resection - sigmoid colon. Expected time of examination: Clinical diagnosis: Tumour of the sigmoid colon tumour. Macroscopic description: A 18 cm length of the large intestine with a piece of mesentery and fat tissue sized 23 X 10.5 X 3 cm. A cauliflower-. shaped, partially ulcerous tumour sized 7.5 X 5.5 X 3 cm found in the mucosa sized 4.5 x 4 X 1.3 cm. The lesion. surrounds 100% of the intestine circumference and narrows its lumen, is located 4.4 cm from one of the incision lines. and 5.9 cm from the other one. The lesion infiltrates macroscopically the whole thickness of the intestine wall and. periintestinal tissues. Microscopic description: Adenocarcinoma tubulopapillare (G2). Infiltratio carcinomatosa tunicae muscularis propriae et serosae coli et telae. adiposae mesenterii pericolicae. Of note is a massive inflammatory invasion, mainly plasmocytic, in the tumour in its. surroundings. Intestine ends free of neoplastic lesions. Minimum side margin is 0.1 cm. Intestine ends free of neoplastic lesions. Metastases carcinomatosae in lymphonodis. (No III/XXXIV). Infiltratio carcinomatosa capsulae lymphonodorum et telae adiposae perinodalis. Histopathological diagnosis: Adenocarcinoma tubulopapillare coli. Tubulopapillar adenocarcinoma of the colon. Metastases carcinomatosae in. lymphonodis. Cancer metastases in the lymph nodes. (No III/XXXIV). (p2, Dukes C, Astler-Coller C2, pT4a, pNI).
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TCGA-D7-A6F0.05B4EA94-C05A-493F-862B-48310D4D4399
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Gender: F. Examination result. Clinical diagnosis (suspicion) Cancer of the cardia. Date of admission: Material: 1) Material: stomach, Method of collection: Total organ resection. Final reult: Stomach adenocarcinoma (G3, pT2, pNO). (8140/3 T-63000). codes according to ICD-O-3 or SNOMED. Macroscopic description: Specimen consisting of the stomach, having been incised along the greater curvature, sized 28.6 x 27.9 cm, with. omentum sized 52 X 18 cm and spleen sized 12.2 x 5.8 x 3.9 cm. In the omentum, spleen with additional diameter of 1 cm and pieces of pancreas sized: 4x 1, 5x2 cm. Tumour sized 12.8 X 11.7 x 2.9 cm in the cardia region on the back wall. Distance from the proximal end: 0.4 cm, from distal end: 23 cm. Microscopic description: Gastric adenocarcinoma (papillary, partially solid type with some mucous cells (mixed type acc. to Lauren class). Cancer infiltrated the whole thickness of the stomach wall and fat tissue of the omentum. Excision lines, omentum and lymph nodes (17) - free of neoplastic lesions. Spleen and pancreas free of neoplastic lesions.
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TCGA-61-1907.ae7e4795-496e-47d0-ad60-cec04e5876b0
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FINAL DIAGNOSIS: PART 1: OMENTUM, OMENTECTOMY -. METASTATIC POORLY DIFFERENTIATED PAPILLARY SEROUS CARCINOMA IN OMENTUM. PART 2: UTERUS, CERVIX (226 GRAMS), RIGHT AND LEFT FALLOPIAN TUBES AND OVARIES, TOTAL ABDOMINAL. HYSTERECTOMY AND BILATERAL SALPINGO-OOPHORECTOMY -. A. CHRONIC CERVICITIS. B. UTERUS WITH METASTATIC PAPILLARY SEROUS CARCINOMA INVOLVING THE SEROSA AND MYOMETRIUM. C. PAPILLARY SEROUS CARCINOMA INVASION OF LYMPHOVASCULAR SPACES IS IDENTIFIED. D. ATROPHIC ENDOMETRIUM. E. SESSILE ENDOMETRIAL POLYP. F. LEIOMYOMATA. G. POORLY DIFFERENTIATED PAPILLARY SEROUS CARCINOMA INVOLVING THE LEFT OVARY AND LEFT. FALLOPIAN TUBE (11.0 X 6.0 X 4.0 CM). RIGHT OVARY WITH METASTATIC PAPILLARY SEROUS CARCINOMA, LYMPHOVASCULAR INVASION AND. BENIGN SEROUS CYST. I. RIGHT FALLOPIAN TUBE, NEGATIVE FOR TUMOR. PART 3: TUMOR, DEBULKING (PELVIC AREA) -. METASTATIC POORLY DIFFERENTIATED PAPILLARY SEROUS CARCINOMA. PART 4: APPENDIX, APPENDECTOMY -. A. METASTATIC PAPILLARY SEROUS CARCINOMA INVOLVING THE MESOSALPINX AND IN LYMPHOVASCULAR. SPACES. B. FIBROUS OBLITERATION OF THE LUMEN. SYNOPTIC - PRIMARY OVARIAN TUMORS INCLUDING BORDERLINE TUMORS. TUMOR LOCATION: Bilateral. PROCEDURE: TAH with salpingo-cophorectomy. TUMOR SIZE: Maximum dimension: 11 cm. TUMOR TYPE: Papiliary serous carcinoma. HISTOLOGIC SILVERBERG GRADE: Poorly differentiated (8-9 pts). ARCHITECTURAL PATTERN: Papillary (2). CYTOLOGIC ATYPIA: Marked (3). MITOTIC COUNTS / 10hpf: 10-24 (2). VASCULAR INVASION: TUMOR CAPSULE: Ruptured. SURFACE IMPLANTS: Invasive. SURFACE IMPLANT SITE: Uterus, Fallopian Tubes, Omentum. SURFACE IMPLANT SIZE: > 2 cm. ASSOCIATED OTHER LESION: Atypia of surface epithelium or surface epithelial inclusion. MALIGNANT CELLS IN ASCITES OR. PERITONEAL WASHING: LYMPH NODES EXAMINED: Total number of lymph nodes examined: 0. LYMPH NODES POSITIVE: Number of positive lymph nodes, Right: 0. Number of positive lymph nodes, Left: 0. EXTRANODAL EXTENSION: T STAGE, PATHOLOGIC: pT3c. N STAGE, PATHOLOGIC: pNX. M STAGE, PATHOLOGIC: pMX. FIGO STAGE: IIIC.
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TCGA-CG-5728.e0aceea3-18b5-4206-8d11-fc93b6e1949e
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Diagnosis(es): Total gastrectomy specimen including an extensively ulcerated, weakly differentiated. adenocarcinoma (intestinal type under Lauren's classification) of maximum diameter. 7.5 cm located in the antrum with infiltration of the perimuscular or subserosal soft tissue. and evidence of lymphatic invasion. Tumor-free regional lymph nodes Free-free oral and. aboral resection margin. Free-free omental fatty tissue. Free stage: pT2b pNO (0/36) pMX;.
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TCGA-ZN-A9VW.C3231F34-1580-4BBC-ABEF-BF2693249E3C
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Report Status: Final. Procedure Date: PATHOLOGIC DIAGNOSIS: A. SKIN, OLD INCISION, EXCISION: Skin and subcutis with scar, negative for tumor. B. RIB: Bone marrow with maturing trilineage hematopoiesis, negative for tumor. C. RIGHT CHEST WALL MASS: MALIGNANT MESOTHELIOMA (0.7 cm), predominantly sarcomatoid type,. involving fibroadipose tissue. Adjacent fibroadipose tissue with foreign body giant cell reaction. D. RIGHT CHEST WALL MASS (INCLUDING FSA) : MALIGNANT MESOTHELIOMA (2.0 cm), mixed epithelial and sarcomatoid type,. involving skeletal muscle and fibroadipose tissue. E. ADDITIONAL RIGHT CHEST WALL MASS: MALIGNANT MESOTHELIOMA, mixed epithelial and sarcomatoid type,. involving skeletal muscle. F. RIGHT PLEURA: MALIGNANT MESOTHELIOMA, mixed epithelial and sarcomatoid type,. involving fibroadipose tissue. G. CHEST WALL RESECTION: MALIGNANT MESOTHELIOMA, multiple nodules (up to 5.5 cm), mixed. epithelial and sarcomatoid type. Tumor invades into fibroadipose tissue, skeletal muscle, and bone. Tumor abuts and focally invades lung parenchyma. Tumor necrosis is present. Tumor is present at the superior, inferior, lateral, medial, chest wall,. and pleural soft tissue margins. Tumor is present at the medial and lateral bony resection margins. H. ADDITIONAL TUMOR: MALIGNANT MESOTHELIOMA, mixed epithelial and sarcomatoid type, with. extensive necrosis. I. RIGHT PLEURA: MALIGNANT MESOTHELIOMA, mixed epithelial and sarcomatoid type, involving. fibroadipose tissue and skeletal muscle. Tumor abuts and focally invades lung parenchyma. J. RIB: MALIGNANT MESOTHELIOMA, mixed epithelial and sarcomatoid type,. involving periosteal fibroadipose tissue. Bone marrow with maturing trilineage hematopoiesis. K. PARATRACHEAL LYMPH NODE: One (1) lymph node, negative for tumor. L. PERICARDIAC TUMOR: MALIGNANT MESOTHELIOMA, mixed epithelial and sarcomatoid type, involving. Page: 1 of 4. fibroadipose tissue. M. VISCERAL PLEURA: MALIGNANT MESOTHELIOMA, mixed epithelial and sarcomatoid type, involving. fibroadipose tissue. Tumor abuts and focally invades lung parenchyma. TISSUE SUBMITTED: A/1). Old incision. B/2) Rib. Rt chest wall mass. D/4). Rt chest wall mass (FS) . E/5). Rt chest wall mass for (. ) FS. F/6). Rt pleura (. ) FS. G/7). Chest wall - long - lateral spine, short - medial spine. H/8). (FS) . I/9). Rt pleura. J/10) Rib. K/11) Paratracheal lymph node. L/12) Pericardiac tumor. M/13) Visceral pleura. O.R. CONSULTATION: SPECIMEN LABELED "#4. RT CHEST WALL MASS" (FSA) : Spindle-cell malignant neoplasm, consistent with mesothelioma. The senior physician certifies that he/she personally conducted a gross and/or. microscopic examination of the described specimen (s) and rendered or confirmed. the rapid diagnos (es) related thereto. GROSS DESCRIPTION: The specimen was received fresh, in thirteen parts, and each labeled with the. patient's name and unit number. Part A, specimen labeled "#1. Old incision", consists of a 21.5 x 0.5 cm skin. excision with an excision depth of 1.1 cm. The specimen was inked blue and. serially sectioned. No masses or lesions were seen. Micro A1: Sections of skin, 5 frags, RSS. Part B, specimen labeled "#2. Rib", consists of a fragment of rib 11.7 cm in. length. No masses or lesions were identified. A successful bone marrow. squeeze was performed. Micro B1: Rib bone marrow, multi frags, RSS. Part C, specimen labeled "#3. Right chest wall mass", consists of a 1.6 x 0.9 x. 0.6 cm red/tan/yellow soft tissue with a firm, tan (0.7 cm in greatest. dimension) nodule. Micro C1: Soft tissue fragment, bisected, 2 frags, ESS. Part D, specimen labeled "#4. Right chest wall mass", consists of a 3.0 x 2.0 x. 1.0 cm soft tissue fragment, which contains a 2.0 x 1.0 x 0.5 cm firm white. nodule. The specimen was bisected and one half of the nodule was submitted as. FSA and the other half of the nodule was submitted to. Page: 2 of 4. Micro D1: FSA remnant, 1 frag, ESS. Micro D2: Non-frozen FSA remnant, 1 frag, ESS. Part E, specimen labeled "#5. Right chest wall mass for. consists of. a 2.8 x 1.8 x 0.7 cm tan/white nodular soft tissue fragment with adherent. tan/red muscular soft tissue. A representative section of the sample was. submitted to. Micro E1: Remaining soft tissue, 2 frags, ESS. Part F, specimen labeled "#6. Right pleura for. consists of a 5.0 x. 4.0 x 1.2 cm aggregate of tan/pink nodular soft tissue fragment. A. representative sample (60%) was divided and sent to. Micro F1-F2: Sections of soft tissue, 1 and 2 frags respectively, RSS. Part G, specimen labeled "#7. Chest wall", consists of a chest wall resection,. measuring 13.6 cm superior to inferior, 11.5 cm medial to lateral, and 13.5. cm. anterior to posterior. The specimen was oriented by the surgeon as long stitch. equals lateral spine, short stitch equals medial spine, and Vicryl equals. superior. The specimen was inked as red equals superior, green equals. inferior, black equals pleural surface, blue equals chest wall surface, yellow. equals lateral spine, and orange equals medial spine. The resection includes. three ribs (9.0, 8.7, and 8.8 cm in length). The superior most rib is. fractured. The pleural surface is relatively smooth and nodular. The largest. aggregate of nodules is 5.5 cm in greatest dimension. Grossly, the nodules are. abutting the chest wall resection edge, less than 0.1 cm/abutting the pleural. surface, less than 0.1 cm from the superior resection margin, abutting the. inferior resection margin, abutting the medial resection margin, and less than. 0.1 cm from the lateral resection margin. The middle rib on the medial side. only contained a small amount of bone protruding to the resection surface. The. lower most rib on the medial side did not extend all the way to the medial soft. tissue resection edge and protruded out more towards the chest wall side. The. tumor appears to grossly invade all three ribs. Micro G1: Medial bone resection margin of the upper most rib, 1 frag, en face,. ESS. Micro G2: Medial bone resection margin of the middle rib, en face, 4 frags,. ESS. Micro G3: Medial bone resection margin of the lower most rib, on chest wall. surface, en face, 1 frag, ESS. Micro G4: Lateral bone resection margin of upper most rib, en face, 1 frag,. ESS. Micro G5: Lateral bone resection margin of the middle rib, en face, 3 frags,. ESS. Micro G6: Lateral bone resection margin of lower most rib, en face, 1 frag,. ESS. Micro G7: Tumor to bone, 1 frag, RSS. Micro G8: Superior margin, perpendicular, 1 frag, RSS. Micro G9: Tumor to pleural and chest wall surfaces, 1 frag, RSS. Micro G10: Tumor to inferior resection margin, perpendicular, 1 frag, RSS. Micro G11: Tumor to lateral soft tissue resection margin, perpendicular, RSS. Micro G12: Tumor to medial soft tissue resection margin, perpendicular, 1 frag,. RSS. Part H, specimen labeled "#8. consists of a 5.6 x 4.4 x 3.9 cm. tan/red nodule with a partially smooth and partially disrupted surface. The. outer surface was inked black. The specimen was sectioned to reveal a tan cut. surface. Micro H1-H2: Sections of nodule, 1 frag each, RSS. Part I, specimen labeled "#9. Right pleura", consists of a 210-gram (16.7 x. 13.8 x 5.2 cm) aggregate of tan, firm soft tissue (tumor) with attached pleura. and fibroadipose tissue. The largest single nodule of tumor measures 4.1 x 3.9. x 3.5 cm. Page: 3 of 4. Micro I1-I4: Sections of tumor, multi frags, RSS. Part J, specimen labeled "#10. Rib", consists of a 6.7 cm in length fragment of. rib with attached skeletal muscle and nodules of tumor, 2.3 cm in greatest. dimension. A successful bone marrow squeeze was performed. Micro J1: Bone marrow, multi frags, RSS. Micro J2: Tumor to bone, 2 frags, RSS. Part K, specimen labeled "#11. Paratracheal lymph node", consists of a 3.0 x. 2.1 x 0.3 cm aggregate of yellow/red soft tissue, which contains a 1.0 x 0.7 X. 0.3 cm black/red lymph node candidate. Micro K1: Lymph node candidate and soft tissue, 2 frags, ESS. Part L, specimen labeled "#12. Pericardial tumor", consists of a 7.4 x 4.0 x. 2.1 cm fragment of fibromembranous tissue with two to three firm tan nodules. (3.5 cm in greatest dimension). Micro L1-L2: Sections of fibromembranous tissue and nodule, 1 and 2 frags. respectively, RSS. Part M, specimen labeled "#13. Visceral pleura", consists of a 16.7 x 13.4 x. 3.1 cm aggregate of red/tan fibromembranous tissue with attached firm tan. nodules (5.1 cm in greatest dimension) There is also scant attached skeletal. muscle and adipose tissue. Micro M1-M4: Sections of tumor and associated tissue, multi frags, RSS. By his/her signature below, the senior physician certifies that he/she. personally conducted a microscopic examination ("gross only" exam if so stated). of the described specimen (s) and rendered or confirmed the diagnosis (es). related thereto.
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TCGA-CH-5769.7d49b105-6652-41b9-8e3a-e806a14de604
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Summary tumor classification. pT3b, maximum tumor diameter 3.3 cm, Gleason 5+4=9, R1, pN0 (0/8). Remark. In the previous punch biopsies the Gleason grading was 4+5=9. In the main preparation the. undifferentiated were predominant, so the concluding classification is 5+4=9. Additional immunohistochemical studies will follow to clarify the vascular status. The. results will be presented in a follow-up report. Microscopy. (Immunohistochemistry: CD31, D2-40). In the additional immunohistochemical studies that have since been carried out in two. representative tumor blocks, there is evidence of a tumor invasion of the lymph vessels. No evidence to suggest invasion of the blood vessels. The concluding tumor classification is thus as follows: pT3b, maximum tumor diameter 3.3 cm, Gleason 5+4=9, L1, V0, R1, pN0 (0/8). M930. Diagnosis. 1. Predominantly undifferentiated, bilateral adenocarcinoma of the prostate extending across the. organ (Gleason 5+4=9). Gleason 5 parts account for 60% of the tumor. Maximum tumor. diameter 3.3 cm. Tumor infiltration of periprostatic fatty tissue in the right apical and left. basolateral region (maximum invasion width 1.5 mm, maximum invasion depth 0.3 mm). Tumor. involvement of the left seminal vesicle, extending focally to the blue-labeled preparation margin. (contact line 1.6mm). Multifocal tumor involvement of perineural sheaths. In addition, numerous foci of a prostatic intraepithelial neoplasia (high-grade PIN) and signs of. myoglandular prostatic hyperplasia. Urothelium of prostatic urethra without dysplasia. 2.6 tumor-free lymph nodes. 3.2 tumor-free lymph nodes. 4. Tumor-free colon resection material. Summary tumor classification. pT3b, maximum tumor diameter 3.3 cm, Gleason 5+4=9, R1, pNO (0/8). Remark. In the previous punch biopsies the Gleason grading was 4+5=9. In the main preparation the. undifferentiated parts were predominant, so the concluding classification is 5+4=9. Additional immunohistochemical studies will follow to clarify the vascular status. The. results will be presented in a follow-up report. Microscopy. (Immunohistochemistry: CD31, D2-40). In the additional immunohistochemical studies that have since been carried out in two. representative tumor blocks, there is evidence of a tumor invasion of the lymph vessels. No evidence to suggest invasion of the blood vessels. The concluding tumor classification is thus as follows: pT3b, maximum tumor diameter 3.3 cm, Gleason 5+4=9, L1, V0, R1, pNO (0/8).
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TCGA-3B-A9HT.1978D473-CA80-4C15-A155-370D9EE56784
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Final Diagnosis. A. TONGUE, RIGHT, GLOSSECTOMY: High-grade leiomyosarcoma, 4.0 cm in greatest dimension (see comment). No lymphovascular space invasion identified. One subglossal lymph node, negative for metastatic carcinoma (0/1). All final margins are free of tumor (see parts B-G). Adjacent squamous mucosa with mild dysplasia. B. DORSAL TONGUE, EXCISION: Squamous mucosa, negative for malignancy. C. VENTRAL TONGUE MARGIN, EXCISION: Squamous mucosa, negative for malignancy. D. FLOOR OF MOUTH MARGIN, EXCISION: Squamous mucosa and salivary gland tissue, negative for malignancy. E. POSTERIOR TONGUE MARGIN, EXCISION: Squamous mucosa, salivary gland tissue, and skeletal muscle, negative for malignancy. F. DEEP TONGUE POSTERIOR MARGIN, EXCISION: Skeletal muscle, negative for malignancy. G. ANTERIOR DEEP TONGUE, EXCISION: Skeletal muscle, negative for malignancy. H. NECK DISSECTION, RIGHT, LEVELS 2-4: Forty four lymph nodes, negative for metastatic carcinoma (0/44). Submandibular gland, free of tumor. I. FLOOR OF MOUTH: Squamous mucosa and underlying salivary gland tissue, skeletal muscle and adipose. tissue, free of tumor. J. TOOTH, REMOVAL: Three fragments of teeth (gross diagnosis only). the attending pathologist, personally reviewed the entire. case and rendered the final diagnosis. Electronically Signed Out by. Comment. Histologic sections of the tumor in the right show a high grade, spindle cell malignancy. Immunohistochemical stains, performed on blocks A4 and A5 with adequate controls, demonstrate the. tumor cells to be strongly and diffusely positive for vimentin and desmin, moderately positive for p16,. weakly positive for actin, and negative for AE1/AE3, CAM5.2, CK5/6, p63, S-100, CD34, calponin,. CD68, myoglobin, pan-melanoma, and smooth-muscle myosin. CD31s shows equiovocal staining. These findings support the above diagnosis of a high-grade leiomyosarcoma. Dr. of the. sarcoma service and Dr. have reviewed this case and concur. Specimen(s) Received. A. RIGHT GLOSSECTOMY. B. DORSAL TONGUE FS. C. VENTRAL TONGUE FS. D. FLOOR OF MOUTH FS. E. POSTERIOR TONGUE FS. F. DEEP POSTERIOR TONGUE FS. G. DEEP ANTERIOR TONGUE FS. H. RIGHT NECK DISSECTION LEVEL 2-4. I. RIGHT FLOOR OF MOUTH. J. TOOTH. Clinical History. None given. Preoperative Diagnosis. Tongue cancer. Intraoperative Consultation. FSB1. DORSAL TONGUE: No evidence of malignancy. FSC1. VENTRAL TONGUE: No evidence of malignancy. FSD1. FLOOR OF MOUTH: Mild dysplasia, no evidence of malignancy. FSE1. POSTERIOR TONGUE: No evidence of malignancy. FSF1. DEEP POSTERIOR TONGUE: No evidence of malignancy. FSG1. DEEP ANTERIOR TONGUE: No evidence of malignancy. Comment: These frozen section diagnoses/results were communicated to and acknowledged by Dr. MD, have performed the intraoperative consultations and issued the above. diagnoses. Gross Description. A. The specimen is received fresh labeled "right glossectomy, double long stitch is posterior floor. of mouth, single long stitch is anterior, double short is medial, dorsal tongue". The specimen consists. of a right partial glossectomy, which measures 5.0 cm from anterior to posterior, 4.0 cm from dorsal to. ventral, and 3.0 cm from medial to lateral. There is an irregular, exophytic, sessile, focally necrotic. and hemorrhagic tumor on the mucosa of the tongue, which measures 4.0 x 4.0 x 0.7 cm. The tumor. is centrally located and 0.5 cm from the closest anterior aspect of the tongue. All the resection. margins of the tongue and floor of mouth are received for frozen section analysis in separate. containers. Prior to sectioning, all the aspects of the specimen are inked black. On sectioning, the. tumor ranges from 0.7 to 2.0 cm in depth and is 0.2 cm from the closest deep aspect of the specimen. Representative sections of the specimen are submitted to the. Representative sections of the specimen are submitted in 10 cassettes as follows: A1: Mirror image of section submitted to the Tissue Procurement Laboratory. A2-A3: Tumor in relation to closest anterior aspect of the tongue, perpendicular sections. A4: Tumor in relation to closest posterior aspect of tongue. A5: Tumor in relation to closest dorsal aspect of tongue. A6: Tumor in relation to closest ventral aspect of tongue. A7: Tumor in relation to closest posterior aspect of floor of mouth. A8-A10: Tumor in relation to closest deep aspect of tongue. B. The specimen is received fresh labeled "dorsal tongue". The specimen consists of an oblong. fragment of pink tan, rubbery tissue partially covered with mucosa. The specimen measures 2.5 x 0.5. x 0.2 cm. No tissue is submitted to the. The specimen is submitted. entirely for frozen section as FSB1. C. The specimen is received fresh labeled "ventral tongue margin". The specimen consists of an. oblong fragment of tan pink to red, rubbery tissue partially covered with mucosa. The specimen. measures 3.0 x 0,5 x 0.2 cm and is submitted entirely for frozen section as FSC1. No tissue is. submitted to the. D. The specimen is received fresh labeled "floor of mouth margin". The specimen consists of an. oblong fragment of pink tan tissue partially covered by mucosa. The specimen measures 2.5 x 0.5 x. 0.2 cm and is submitted entirely for frozen section as FSD1. No tissue is submitted to the. E. The specimen is received fresh labeled "posterior tongue margin". The specimen consists of. an oblong fragment of pink tan, rubbery tissue partially covered with mucosa. The specimen. measures 2.0 x 0.5 x 0.2 cm and is submitted entirely for frozen section as FSE1. No tissue is. submitted to the. F. The specimen is received fresh labeled "deep tongue posterior margin". The specimen. consists of an irregular fragment of tan red to brown, rubbery tissue measuring 2.0 x 1.5 x 0.2 cm. No. tissue is submitted to the. The specimen is entirely submitted for. frozen section as FSF1. G. The specimen is received fresh labeled "anterior deep tongue". The specimen consists of an. irregular fragment of tan red brown, rubbery tissue measuring 1.5 x 1.5 x 0.2 cm. No tissue is. submitted to the. The specimen is entirely submitted for frozen. section as FSG1. H. The specimen is labeled "right neck dissection 2-4, double stitch marks level 4, single stitch. level 2." The specimen consists of a submandibular gland (3.5 x 2.5 x 1.5 cm) with a large amount of. fibroadipose tissue attached. The specimen measures in overall dimension 11 x 4 x 2 cm. The. specimen is oriented according to the surgeon designation and is divided into 4 levels, 1-4. The. submandibular gland is serially sectioned to reveal grossly unremarkable pink-tan, lobulated cut. surface. No sternocleidomastoid muscle or internal jugular vein is identified. The specimen is. oriented according to the surgeon designation and is divided into 4 levels, 1-4. On sectioning, the. fibroadipose tissue of the level 1-4 multiple potential lymph nodes are grossly identified, which range. from 0.1 to 1.7 cm in greatest dimension. No tissue is submitted to the. Representative sections of the specimen are submitted in 20 cassettes as follows: H1: Submandibular gland. H2: Two lymph nodes, level 1. H3: Three lymph nodes level 1. H4: One lymph node, level 2. H5: Three lymph nodes, level 2. H6: One lymph node, level 2. H7: One lymph node, level 2. H8: Two lymph nodes, level 2. H9: One lymph node, level 2. H10: One lymph node, level 3. H11: One lymph node, level 3. H12-H14: Nine lymph nodes, level 3, 3 lymph nodes per cassette. H15: Four lymph nodes, level 3. H16: Three fymph nodes, level 3. H17-H20: Twelve lymph nodes, level 4, 3 lymph nodes per cassette. I. The specimen is received fresh labeled "right floor of mouth". The specimen consists of an. irregular to oblong, unoriented fragment of tan red brown, rubbery tissue, which is partially covered by. mucosa. The specimen measures 4.5 x 1.8 x 0.7 cm. The specimen has not been oriented by the. surgeon and all the resection margins are inked black. No tissue is submitted to the. The specimen is serially sectioned and is submitted entirely in 6 cassettes,. I1-16. J. The specimen is labeled "tooth." The specimen consists of 3 fragments of teeth, which are. ranging from 0.7 to 1.3 cm in greatest dimension. The fragments consistent with teeth roots. One. tooth also contains an irregular fragment of crown. No tissue is submitted to the. The specimen is received for gross analysis only.
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TCGA-AJ-A2QO.5351BF98-9E1D-4F4D-A3EE-26A83B867D58
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PROCEDURE DATE: RECEIVED DATE: REPORT DATE: Pre-Op Diagnosis. Endometrial cancer. Post-Op Diagnosis. Same as above. Clinical History. Nothing indicated. Gross Description: Five parts. 1 - left pelvic lymph nodes" is 5.1. Container labeled. x 2.6 x 1.8 cm portion of tan yellow fibroadipose tissue which on. 4/3/1/. palpation and sectioning reveals five poorly defined tan yellow to. brown nodules from 1.1 to 2.1 cm. On sectioning the larger nodules. have fleshy and fatty cut surfaces. The largest nodule is sectioned. and submitted labeled A-B; remaining nodules bisected and. individually submitted labeled C-F. Container labeled. 2 - left aortic lymph nodes" is 4.8. x 1 5 x 1.0 cm elongated portion of tan yellow fibroadipose tissue. which on palpation and sectioning reveals three poorly defined tan. yellow nodules up to 1.5 cm. On sectioning the larger nodules have. fleshy and fatty cut surfaces. The largest nodules are bisected and. individually submitted labeled A-B; whole smallest nodule submitted. labeled C. Container labeled. 3 - right pelvic lymph nodes" is. 9.0 x 3.5 x 1.8 cm portion of tan yellow fibroadipose tissue which. on palpation and sectioning reveals several poorly defined tan. yellow nodules up to 3.4 cm. On sectioning these have fleshy and. fatty cut surfaces. The largest nodule is sectioned and submitted. labeled A-C; individual nodules bisected and submitted labeled D-F;. whole smaller nodules submitted labeled G. Container labeled. 14 - right aortic lymph nodes" is. 4.9 x 3.5 x 1.5 cm tan yellow fibroadipose tissue fragments which on. palpation and sectioning reveals two poorly defined tan yellow. nodules 2.5 cm and 3.8 cm. On sectioning there are fleshy and fatty. cut surfaces. The largest nodule is sectioned and submitted labeled. A-B; smaller nodule bisected and submitted labeled C. Container labeled. 5 - uterus, cervix, bilateral tubes. and bilateral ovaries" is a previously laterally opened moderately. distorted uterus with attached cervix and bilateral adnexa. The. uterus and cervix together weigh 87 grams and on reconstruction. measure approximately 6.9 x 6.4 x 4.7 cm. The cervix has a wrinkled. gray-tan ectocervical mucosa. The os is patent. The uterine canal. sounds to a depth of approximately 5.8 cm. The endocervical canal. is lined by trabeculated tan gray to brown mucosa. The uterine. serosa is smooth and tan-brown. The architecture is distorted by. the presence of a left fundic subserosal nodule 1.6 cm as well as a. left lateral subserosal to intramural nodule 1.8 cm. The lateral. nodule has a bulging whorled tan gray fibrotic cut surface while the. fundic nodule has a focally calcified cut surface. The uninvolved. myometrium measures up to 1.9 cm and is tan-pink and fibrotic. The. endometrial canal is lined at the fundus extending to both the. anterior and posterior aspects by a 3.5 x 3.3 x up to 0.9 cm friable. granular gray tan to pink papilliferous plaque like lesion. On. sectioning this has a friable gray pink cut surface and grossly. extends into the myometrium in the right lateral fundic region to a. maximum thickness of 2.4 cm. This is focally noted at its nearest. point 0.3 cm from the right lateral serosa. The small amount of. parametrial soft tissue on each side shows no nodularity or gross. lesions. The left fallopian tube measures 4.1 x 0.5 x 0.5 cm. The. right fallopian tube measures 4.5 x 0.5 x 0.5 cm. Each has a smooth. tan brown serosa with a tan wall and pinpoint lumen. The left ovary. measures 1.5 x 1.0 x 0.8 cm and has a lobular tan outer surface with. a. mottled tan gray fibrotic cut surface. The right ovary measures. 1.6 x 0.9 x 0.7 cm and has a lobular tan outer surface with a. mottled tan gray fibrotic cut surface. Also received in the same. container are 6.2 x 5.0 x 1.8 cm of friable granular papilliferous. gray tan to pink lesional tissue fragments with a small amount of. clotted blood. Also received in the same container are two tissue. cassettes each labeled. Representative sections. are submitted labeled as TOILOWS: A - anterior cervix; B - posterior. cervix; C - lower uterine segment and shaved posterior serosa; D. representative fundic subserosal nodule; E-G - anterior. endomyometrium; H-K - posterior endomyometrium; L-M - left lateral. endomyometrium; N-O - right lateral endomyometrium; P-S - fundic. endomyometrium; T - left parametrium; u - right parametrium; V -. left adnexa; w - right adnexa; x - separate lesional tissue. Microscopic Description: Slides reviewed. Final Diagnosis. Left pelvic lymph node dissection: Five benign hyperplastic regional lymph nodes (0/5). Left aortic lymph node dissection: Three benign hyperplastic regional lymph nodes (0/3). Right pelvic lymph node dissection: Six benign hyperplastic regional lymph nodes (0/6). Right aortic lymph node dissection: Two benign hyperplastic regional lymph nodes (0/2). Hysterectomy: Carcinoma of endometrium. Tumor characteristics: Histologic type: Predominantly endometrioid with some mucinous. features. Histologic grade: High grade (G3). Location: Endometrial canal in general. Tumor size: 3.5 x 3.3 x 1.6 cm. Extent of invasion: Invades more than one half of the myometrium. Maximal thickness of myometrial invasion is 16 mm into a 19 mm. thick myometrium. Extension of tumor: Extent of involvement of other organs: None identified. Lymphovascular space invasion: Focally identified. Surgical margin status: Cervical: Negative. Left parametrial: Negative. Right parametrial: Negative. Lymph node status (utilizing specimens #1, 2, 3, 4. Sites: Bilateral pelvic, bilateral aortic. Number of lymph nodes examined: 16. Number of lymph nodes containing metastatic carcinoma: None. (0/16). Other. Cervix-endocervix: No pathological diagnosis. Endometrium: Focal complex hyperplasia with atypia immediately adjacent to. neoplasm. Myometrium: Adenomyosis, leiomyomas. Uterine serosa, bilateral ovaries and fallopian tubes: No pathological diagnosis. Other organs or biopsies: None. Correlation with intraoperative findings: None. Results of additional studies: None. PTN stage: pT1bNO PAS 9 SPC-A. CPT: Comments. This test has been finalized at the.
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TCGA-CZ-5463.324d4d25-e72e-4faa-bd17-6c2201a2d6ce
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Report Status: Amend/Addenda. Type: Surgical Pathology. Specimen Type: Kidney. partial or total resection. Procedure Date: PATHOLOGIC DIAGNOSTS: SPECIMEN DESIGNATED "LEFT KIDNEY". our. UL. 5463. RENAL CELL CARCINOMA (12.8 cm) Clear cell type,. Fuhrman nuclear grade II/IV. The tumor abuts but does not invade the renal capsule. The tumor invades the renal sinus and abuts the endothelium. of large veins (tumor is not present in the renal vein). The tumor shows extensive hyalinization. The ureter, renal artery, and renal vein resection margins are. negative for tumor. AJCC Classification: T3a Nx MX. The non-neoplastic kidney will be evaluated by the Renal Pathology. Division, and the findings will be reported in an addendum. CLINICAL DATA: History: None given. Operation: Left radical nephrectomy. Operative Findings: None given. Clinical Diagnosis: Left renal mass. ORGANS/TISSUE SUBMITTED: A/1. Left kidney. GROSS DESCRIPTION: The specimen is received fresh, in one part, labeled with the patient' name,. medical record number and "Left kidney", and consists of a 1642-gram. nephrectomy specimen (24.5 x 13.0 x 9.8 cm) with ureter (11.5 in length x 0.4. cm in diameter). renal vein (1.3 cm in length x 0.5 cm in diameter), and renal. artery (2.3 cm in length x 0.5 cm in diameter) No adrenal glands are. identified. There is a tan/red to tan/yellow, loculated, partially. encapsulated mass (12.8 x 10.3 x 8.5 cm) in the lower pole, replacing the. majority of the lower pole parenchyma. It is less than 0.1 cm to the black. inked resection margin, 6.0 cm to the ureteral margin, 2.0 cm to the renal vein. margin, and 2.2 cm to the renal artery resection margin. The tumor extends to. the surface of the adhesed ureter. Representative sections of the tumor are. submitted for cytogenetics, EM, quick fix, and tissue bank. Representative. sections of the normal renal parenchyma are submitted for tissue banking, IF,. and EM. Gross photographs are taken. Micro A1: Resection margin for the renal vein, the renal artery, and. the ureter, 3 frags,. Micro A2-A4 : Representative sections of the tumor, 3 frags in A2, 1 frag. in. A3 and 2 frags in A4, 6 frags total,. Micro A5: The tumor in relation to the closest resection margin, which. was inked black, 1 frag,. Micro A6-A. Tumor in relation to the adhesed ureter, 2 frags, 1 frag in. each block,. Micro A8: The tumor in relation to the renal pelvis, 1 frag,. Micro A9: The tumor in relation to perirenal adipose tissue, 1 frag,. Micro A10: The tumor in relation to surrounding normal renal. parenchyma,. 1 frag,. Micro All: The normal renal parenchyma, 1 frag,. Page: 1. Report Status Final. Type: Cytogenetics. KARYOTYPE: T1:42,X,-Y,-3,-8,-14[5) T3 :42,-Y,-3,-8,-14[5) -. METAPHASES COUNTED: 10. ANALYZED: 10. SCORED : 0. BANDING: GTG. INTERPRETATION: Three different specimens from this tumor were received. All metaphases from specimens labeled T1 and T3 contained clonal aberrations. including monosomy for chromosome 3, which is a typical finding in renal cell. carcinoma, clear cell type. COMMENTS: Mosaicism and small chromosome anomalies may not be detectable using the. standard methods employed. Chromosome analysis was performed at a level of 400. bands or greater. No metaphases were available from specimen T2, therefore the cytogenetic. analysis could not be performed. INDICATION FOR TEST: ? RCC; Kidney Tumor #1-#3.
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TCGA-3U-A98G.7462A92B-C657-4D38-BF7C-0EC9639E7E4D
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Gender: Male. Race: White. Report Date: Tissue Procurement Date: FINAL PATHOLOGIC DIAGNOSIS. A. #11 lymph node; biopsy: - Two lymph nodes, no tumor (0/2). B. Level 7 lymph node; dissection: - Three lymph nodes, no tumor (0/3). C. #8 lymph node; biopsy: - One lymph node, no tumor (0/1). D. 4R lymph node; biopsy: - Two lymph nodes, no tumor (0/2). E. Right parietal and visceral pleura, diaphragm and pericardium: - Malignant biphasic mesothelioma; see comment. - See parameters. Thoracic Mesothelioma Pathologic Parameters. Pleura Resection. MACROSCOPIC. Specimen Type: Pleural resection. Tumor Site: Right pleura, pericardium, and diaphragm. Tumor Configuration and Size: Diffuse, maximum thickness: 3.5 cm. MICROSCOPIC. Histologic Type: Biphasic mesothelioma (80% epithelioid, 20% sarcomatoid). Tumor Extension: Confluent visceral pleural tumor (including fissure). Into but not through diaphragm. Into and through the pericardium. Venous/Lymphatic (Large/Small Vessel) Invasion: Absent. Margins: Cannot be assessed. Pathologic Staging (pTNM): pT4, NO. Primary Tumor (pT). pT4: Tumor (locally advanced technically unresectable) involves any of the. ipsilateral pleural surfaces, with at least lof the following: diffuse or. multifocal invasion of soft tissues of the chest wall, any involvement of rib,. invasion through the diaphragm to the peritoneum, invasion of any mediastinal. organ(s), direct extension to the contralateral pleura, invasion into the spine,. extension to the internal surface of the pericardium, pericardial effusion with. positive cytology, invasion of the myocardium. Regional Lymph Nodes (pN). pN0: No regional lymph node metastasis. Specify: Number examined: 8. Number involved: 0. Comment. Immunohistochemical staining with CAM5.2 was positive in both epithelioid and. sarcomatoid mesothelioma. Of note, expansile nodules composed of sarcomatoid. mesothelioma are seen at the diaphragm with epithelioid and spindle cells. extending into the muscle. In the invasive ares, only the epithelioid cells. stain positively for CAM5.2, whereas the spindled cells are negative. This shows. epithelioid mesothelioma extension into the diaphragm, but spindled cell within. the diaphragm may reflect desmoplastic stroma. In addition, CD34 stain shows no. venous or lymphatic invasion. All controls are appropriate. Dr. has. reviewed the case and concurs. M.D. Interpretation performed by the Attending Pathologist and reviewed with the. Resident/Fellow, , MD. Clinical History: The patient is a -year-old male with mesothelioma undergoing right. thoracotomy, pleurectomy, and decortication. Specimens Received: A: #11. B: Level 7. C: #8. D: 4R. E: Right parietal visceral pleura diaphragm and pericardium. Gross Description: The specimens are received in five containers each labeled with the patient's. name and medical record number. A. The first container is additionally identified as, "1. #11". Received fresh. and placed in formalin are 2 gray-black nodular, rubbery fibrofatty tissue. fragments measuring 0.8 x 0.7 X 0.6 cm and 1.2 x 0.7 x 0.6 cm. Each nodule is. bisected. A thin section of tissue is detached from the larger nodule during. bisection. The smaller nodule is submitted entirely in A1, and the larger nodule. along with the detached fragment is submitted in A2. B. The second container is additionally identified as, "2. Level 7". Received. fresh and placed in formalin are 3 grey-black nodular, rubbery fibrofatty tissue. fragments measuring 0.8 x 0.4 x 0.3 cm, 1.9 x 1.1 x 0.6 cm, and 1.9 x 1.1 x 0.8. cm. Each nodule is bisected and submitted entirely in B1-B3. C. The third container is additionally identified as, "3. #8". Received fresh. and placed in formalin is a grey-black nodular, rubbery fibrofatty tissue. fragment measuring 1.8 x 1.2 x 0.6 cm. The specimen is bisected and submitted. entirely in C1. D. The fourth container is additionally identified as, "4. 4R". Received fresh. and placed in formalin are 2 brown-tan rubbery tissue fragments measuring 1.1 x. 0.5 X 0.4 cm and 1.5 x 1 x 0.3 cm as well as a gray-black lobulated, rubbery. fibrofatty tissue fragment measuring 3.1 x 2.3 x 0.3 cm. The 2 brown-tan. fragments are submitted entirely in D1. The gray-black larger tissue fragment is. divided and submitted entirely in D2-D3. E. The fifth container is additionally identified as, "5. Right parietal. visceral pleura, diaphragm + pericardium black stitch marks pericardium, white. stitch marks diaphragm". Received fresh is a 575 gm, 600 ml pleurectomy specimen. measuring 31 x 16 x 3 cm. There is an attached 6.5 x 2.5 cm surface of smooth,. pink-tan pericardium, which is 0.2 cm thick. There is a 13 x 11 cm portion of. attached red-brown, ragged diaphragm, which is 0.8 cm thick. The specimen is. inked as follows: pericardial surface - blue, abdominal surface of diaphragm -. black. The specimen is sectioned to reveal white, firm, lobulated tumor present. throughout the visceral pleura. Greater than 90% of the pleura is involved by. tumor. The visceral and parietal pleura are thickened (up to 0.5 cm) and fused. The tumor invades the diaphragm up to a depth of 0.8 cm, which comes to <0.1 cm. to the inked margin. The abdominal surface of the diaphragm is free of tumor. The greatest tumor dimension is 3.5 cm. Gross photographs are taken. Representative sections are taken as follow: E1-E2: Pericardium. E3-E9: Diaphragm. E10-E15: Pleura and chest wall. MD.
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TCGA-06-5414.40314de5-33f1-4b29-85a1-d6292c6e2fc3
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CLINICAL HISTORY. Right temporal brain tumor. OPERATIVE DIAGNOSES. Operation/Specimen: A: Glioblastoma, biopsy. B: Glioblastoma, biopsy. PATHOLOGICAL DIAGNOSIS: A. and B. Brain, right cerebral tumor, excision biopsy: Glioblastoma (WHO. Grade IV) (see comment) . COMMENT. Permanent sections confirm the frozen section diagnosis. Sections show a. moderately pleomorphic, densely cellular glioma demonstrating frequent. mitotic. figures, vascular proliferation and pseudopalisadine necrosis. Reactive. changes consistent with prior surgical intervention are also present. Immunohistochemical stains show that the tumor cells are diffusely GFAP. positive. The Ki-67 labeling index is up to approximately 30%. Positive and negative controls show appropriate immunoreactivity. Results of MGMT promoter methylation assay will be reported below in. a. procedure addenda. PROCEDURES/ADDENDA. MGMT Promoter Methylation. Interpretation. NEGATIVE: No evidence of methylated MGMT promoter is detected. Results-Comments. Testing performed on DNA extracted from tumor paraffin block. TEST DESCRIPTION: Patients with glioma containing a methylated MGMT promoter. have been shown to benefit from therapy with alkylating agents. Assessment. of. MGMT promoter methylation status involves bisulfite treatment of DNA. followed. by real-time PCR amplification (MethyLight) of methylated and unmethylated. DNA. sequences. The analytic sensitivity of this assay was determined by serial. dilution of methylated positive control DNA into unmethylated DNA, and was. assessed to be 1% of methylated DNA in the background of unmethylated DNA. Factors such as the presence of >50% non-neoplastic cells in the sample, or. extensive tissue necrosis, may preclude the detection of methylated MGMT. promoter sequences. FDA COMMENT: The above data are not to be construed as the results from a. stand alone diagnostic test. This test was developed and its performance. characteristics determined by the. laboratory as. required by CLIA. regulations. It has not been cleared or approved for. specific uses by the U.S. Food and Drug Administration (FDA) The FDA has. determined that such clearance or approval is not necessary. These results. are. provided for informational purposes only, and should be interpreted only in. the context of established procedures and/or diagnostic criteria. INTRA-OPERATIVE CONSULTATION. A. Brain, right cerebral tumor, biopsy: High-grade glioma (consistent with. glioblastoma). . Frozen section and smears performed at. results reported to the Physician of Record. Senior Staff Pathologist. GROSS DESCRIPTION. A. Glioblastoma, biopsy: CONTAINER LABEL: Glioblastoma. FIXATIVE: None. NO. PIECES: 2. SIZE/VOL: 3 mm each of gray, hemorrhagic. brain tissue. Portions of each piece used for frozen section and smears. CASSETTES: 1,. B. Glioblastoma, biopsy: CONTAINER LABEL: glioblastoma. FIXATIVE: Formalin. NO. PIECES: 1. SIZE/VOL: 15 x 10 X 4 mm. CASSETTES: ICD-9(s) : 191.2 191.2. Histo Data. Part A: Glioblastoma, biopsy. Stain/cnt. Block. Comment. FS H/E X 1. 1. H/E x 1. 1. TPS H/E X 1. 1. H/E x 1. 2. mGFAP-DA X 1. 3. H/E X 1. 3. MGMT-curls X 1. 3. MIB1-DA x 1. 3. Rct 1 H/E X 1. 3. Part B: Glioblastoma, biopsy. Stain/cnt. Block. Comment. H/E X 1. 1.
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TCGA-HT-A618.1E45E711-0DF2-43BD-8E84-888813B93769
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Microscopic Description: Sections demonstrate a hypercellular astrocytic neoplasm. The tumor is identified infiltrating cortical. grey matter. The neoplastic cells demonstrate moderate to marked cytoligic atypia. Many of the tumor. cells demonstrate significant nuclear atypia, including hyperchromatic enlarged pleomorphic nuclei. The. tumor cells demonstrate features consistent with gemistocytic differentiation, including abundant. eosinophillic cytoplasm and nuclear p53 positivity. An occasional blood vessel demonstrates pervascular. lymphocytes. Significant mitotic activity is not seen. The MIB-1 LI is 2.8%. Microvascular proliferation. and necrosis are not seen. Diagnosis: Left Temporal Tumor. Anaplastic gemistocyic astrocytoma (who grade III). 941/13.
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TCGA-AX-A0IW.DE971C2D-31E8-42AC-A943-29E76FCD8F68
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00:00 Final. (Age: I. Accessioned: DIAGNOSIS: UTERUS, ENDOMYOMETRIUM, TOTAL ABDOMINAL HYSTERECTOMY. - HIGH-GRADE SEROUS PAPILLARY ADENOCARCINOMA (SEE SYNOPSIS). - CARCINOMA INVADES MYOMETRIUM TO A DEPTH OF 3 MM OUT OF 11 MM. LOWER UTERINE SEGMENT IS INVOLVED BY CARCINOMA. VASCULAR SPACE INVASION BY CARCINOMA IDENTIFIED. - LEIOMYOMATA (LARGEST MEASURES 4 MM IN GREATEST DIMENSION). UTERUS, CERVIX, TOTAL ABDOMINAL HYSTERECTOMY. - MILD CHRONIC INFLAMMATION. - NO DYSPLASIA OR MALIGNANCY. FALLOPIAN TUBE, LEFT, BILATERAL SALPINGO-OOPHORECTOMY. - INVOLVED BY HIGH-GRADE PAPILLARY SEROUS CARCINOMA (SEE COMMENT). FALLOPIAN TUBE, RIGHT, BILATERAL SALPINGO-OOPHORECTOMY. - NO EVIDENCE OF MALIGNANCY. OVARY, LEFT, BILATERAL SALPINGO-OOPHORECTOMY. - NO EVIDENCE OF MALIGNANCY. OVARY, RIGHT, BILATERAL SALPINGO-OOPHORECTOMY. NO EVIDENCE OF MALIGNANCY. LYMPH NODES, LEFT EXTERNAL ILIAC, DISSECTION. - FIVE LYMPH NODES WITH NO EVIDENCE OF MALIGNANCY (0/5). LYMPH NODES, LEFT OBTURATOR, DISSECTION. - THREE LYMPH NODES WITH NO EVIDENCE OF MALIGNANCY (0/3). LYMPH NODES, RIGHT EXTERNAL ILIAC, DISSECTION. - NINE LYMPH NODES WITH NO EVIDENCE OF MALIGNANCY (0/9). LYMPH NODES, RIGHT OBTURATOR, DISSECTION. - SEVEN LYMPH NODES WITH NO EVIDENCE OF MALIGNANCY (0/7). LYMPH NODES, RIGHT COMMON PERIAORTIC, DISSECTION. - FIVE LYMPH NODES WITH NO EVIDENCE OF MALIGNANCY (0/5). Page of 4. Page. 1 of 4. LYMPH NODES, LEFT COMMON PERIAORTIC, DISSECTION. - FOUR LYMPH ODES WITH NO EVIDENCE OF MALIGNANCY (0/4). OMENTUM, OMENTECTOMY. - NO EVIDENCE OF MALIGNANCY. By this signature, I attest that the above diagnosis is based upon my personal. examination of the sildes(and/or other material Indicated in the diagnosis). Feport Electronically Reviewed and Signed Out by. Intraoperative Consultation: An intraoperative non-microscopic consultation was obtained and interpreted as: "Called to pick up 'uterus, BSO, and. cervix,' consisting of a 107 gram uterus (9.2 x 6.2 x 3.3 cm) with attached bilateral fallopian tubes (right 5.7 x 0.7 x 0.6. cm; left 63 x 1.5 x 1.5 cm), and ovaries (right 3 x 1.5 x 0.8 cm; left 3 x 1.4 x 0.7 cm). The uterus 13 bivalved to show a. pink-tan polypold exophytic mass occupying the entire endometrial cavity (tumor measures 4.3 x 4.2 cm on the. posterior half, and 5.0 x 4.2 cm on the anterior half). The specimen is shown to the surgeon. Tissue is taken for. and tumor bank. Rest for permanents, by. Microscopic Description and Comment: The serous carcinoma in the left fallopian tube exhibits predominantly Intraluminal growth, with muscular wall invasion. identified. While a second primary arlsisng in the tube is in the differential diagnosis, the consensus of the. is that this represents a metastasis from the endometrial primary. History: The patient is a year old woman with no further history provided. Operative procedure: Exploratory laparotomy,. abdominal hysterectomy, and bilateral salpingo-oopharectomy. Specimen(s) Received: A: UTERUS, BILATERAL TUBES AND OVARIES, CERVIX. B: LYMPH NODE, LEFT EXTERNAL ILIAC. C: LYMPH NODE, LEFT OBTURATOR. D: LYMPH NODE, RIGHT EXTERNAL ILIAC. E: LYMPH NODE, RIGHT OBTURATOR. F: LYMPH NODE, RIGHT COMMON/PERIAORTIC. G: LYMPH NODE, LEFT COMMON/PERIAORTIC. H: OMENTUM. Gross Description;. The specimens are received in eight formalin-filled containers, each labeled. ". The first container is. labeled "uterus, BSO, and cervix. It consists of a previously described 107 gram uterus measuring 9.2 cm from. fundus to cervix, 6.2 cm from comu to cornu, and 3.3 cm in the anterior/posterior plane. Both right and left ovaries and. fallopian tubes are present. The right ovary shows a tan-yellow, cerebriform external surface, and measures 3.0 x 1.5. x. 0.8 cm. The right fallopian tube is grossly unremarkable and measures 5.7 cm in length and up to 0.7 cm In. Page: 2 of 4. diameter. The left ovary shows a similar tan-yellow cerebriform external surface, and measures 3.0 x 1.4 x 0.7 cm,. The left fallopian tube measures 6.3 cm in length. The distal third of the left fallopian tube is enlarged up to 1.5 cm in. dimension. The serosal surface of the uterus is intact and shows no gross involvement by tumor. The uterus has been. previously bivalved to show a fungating lesion, virtually filling the endometrial cavity and grossly extending to the. superior aspect of the lower uterine segment. Tumor does not extend to the endocervix. Both the anterior and. posterior uterine corpus are sectioned. This shows tumor infittration 3 mm into an 11 mm myometrium in the fundic. aspect of the endomyometrium. Labeled A1 - posterior cervix and lower uterine segment; A2 - anterior cervix and. lower uterine segment; A3 to A5 - tumor in anterior endomyometrium; A6, A7 - tumor in posterlor endomyometrium; A8. tumor in fundus; A9 - right fallopian tube and ovary; A10 left ovary and non-tumor fallopian tube; A11, A12 - sections. of fallopian tube tumor. Jar 2. The second container is labeled "left external iliac.' It contains portions of fibrofatty tissue measuring 3.5 x 3.0 x 1.0. cm. From this, five potential lymph nodes are dissected. Labeled B1 - one lymph node bisected; B2 - four tymph. nodes. Jar 1. The third container Is labeled "teft obturator. It holds a portion of fibrofatty tissue measuring 3.d x 2.5 x 1.3 cm. From. this, one large and one small lymph node are dissected. Labeled C1 - small lymph node; C2 - one lymph node,. bisected. Jar 0. The fourth container is labeled "right external Iliac." It holds a portion of fibrofatty tissue measuring 4.0 x 3.5 x 1.3 cm. From this, eight potential lymph nodes are dissected. Labeled D1 - one fymph node bisected; D2 - four lymph nodes;. D3 - one lymph node bisected; D4 - two lymph nodes. Jar 1. The fifth container is labeled "right obturator." It holds a portion of fibrofatty tissue measuring 4.5 x 2.8 x 1.8 cm. From. this, eight potential lymph nodes are dissected. Labeled E1 - four lymph nodes; E2 - two lymph nodes; E3 - two. lymph. nodes. Jar 1. The sixth container is labeled "right common periaortic lymph nodes. It consists of a portion of fibrofatty tissue. measuring 5.0 x 3.0 x 1.8 cm. From this, five potential lymph nodes are dissected. Labeled F1 - one lymph node,. bisected; F2 - two lymph nodes; F3 - two lymph nodes. Jar 0. The seventh container is labeled "left common periaortic." It consists of two portions of fibrofatty tissue measuring 3.0. x 2.3 x 1.1 cm in aggregate. From this, four potential lymph nodes are dissected. Labeled G1 . three lymph nodes; G2. - one lymph node bisected. Jar 0. The eighth container is labeled "omentum." It holds a portion of omentum measuring 20.0 x 7.5 x 1.0 cm. Sectioned to. show no gross evidence of tumor. Labeled H1 to H5. Jar 2. SYNOPTIC REPORTING FORM FOR MALIGNANT ENDOMETRIAL TUMORS. HISTOPATHOLOGIC TYPE. The histologic diagnosis is adenocarcinoma, serous papillary type. TUMOR INVASION. Invasive tumor is present with superficial invasion into the luminal 1/3 of the myometrium. TUMOR SIZE. The tumor invades to a depth of 3 mm. The myometrial thickness is 11 mm. LOWER UTERINE SEGMENT INVOLVEMENT. (does not change the stage). The lower uterine segment is involved by tumor. ENDOCERVICAL INVOLVEMENT. Page: 3 of 4.
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TCGA-WK-A8XO.1AE1A944-8D73-405E-9670-5ADC3F8906E8
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Report Status: Final. Type : Surgical Pathology. Specimen Type: Peritoneum. Procedure Date: Resident: PATHOLOGIC DIAGNOSIS: A. LEFT PELVIC SIDE WALL DEPOSIT: Fibrovascular tissue with chronic inflammation. and foreign body giant cell reaction, negative. for tumor. B. RIGHT RETROPERITONEAL MASS. DEDIFFERENTIATED LIPOSARCOMA. 5 cm. Mitoses number 40:10 HPF. No necrosis identified. C. OMENTAL NODULE: DEDIFFERENTIATED LIPOSARCOMA involving. fibroadipose tissue. D. ILEUM AND RIGHT COLON: DEDIFFERENTIATED LIPOSARCOMA, 1.9 cm, involving the wall. of the small intestine, invading into the submucosa. Colonic and ileal resection margins are negative for tumor. Four lymph nodes, negative for tumor (0:4). E. SMALL BOWEL MESENTERY LYMPH NODES: Three lymph nodes, negative for tumor (0:3). CLINICAL DATA: History: Dedif LPS. Operation: Resection of duodenal liposarcoma, sm bowel resection. Operative Findings: Not provided. Clinical Diagnosis: Duodenal liposarcoma. TISSUE SUBMITTED: A. LT pelvic side wall deposit. B. RT retroperitoneal mass - short sup - long lat - tissue bank. C. Omental nodule. D. Ileum + RT colon. E. Sm bowel mesentery lymph node. GROSS DESCRIPTION: The specimen is received fresh, in five parts, labeled with the patient's name. and unit number. Part A, "#1. Left pelvic sidewall deposits", consists of soft tissue fragments. of 2.5 x 1.0 x 1.0 cm. Micro A1: Soft tissue fragments, 1 frag,. Part B, "#2. Right retroperitoneal mass stitch superior, long posterior tissue. bank", consists of a 35.5-g tan/yellow lobulated multifocally disrupted. oriented soft tissue mass (5 x 5 x 4.5 cm) with a short stitch superior and. long stitch lateral. The excision appears marginal grossly. The specimen is. inked per protocol. There is on the lateral aspect of the specimen additional. fatty piece attached measuring 2.7 x 2.1 x 0.6 cm. There is a tan/white. lobulated firm cut surface of the tumor. Representative section of the tumor. Page: 1 of 2. la. is submitted for cytogenetics and tissue bank and for. lab. Photograph is taken. Micro B1: Medial inferior lateral margin, 1 frag,. Micro B2: Anterior medial margin, 1 frag,. Micro B3: Posterior inferior margin. 1 frag,. Micro B4: Lateral margin, 2 frag,. Micro B5: Medial superior margin, 1 frag,. Micro B6: Anterior inferior margin, 1 frag,. Micro B7: Superior resection margin, 1 frag,. Micro B8-B10: Additional tumor sampling, 3 frags,. Part C, "#3. Omental nodule", consists of a white firm nodule of 1.2 cm in. diameter. Micro C1-C2: Nodule bisected, 2 frags,. Part D, "#4. Ileum and right colon frozen section", consists of a segment of. ileum measuring 34.0 cm in length x 3.0 cm in diameter with a right colon of. 12.0 cm in length x 8.0 cm in diameter with a radial resection margin of 6.0. cm. The mucosa of the bowel is unremarkable. There is mesenteric nodule in. the terminal ileum measuring 1.6 cm in diameter pushing the submucosa located. at 20.0 cm from the ileal resection margin and 11.0 cm from the ICV. Micro D1: Ileal resection margin, 1 frag,. Micro D2: Colon resection margin, 1 frag,. Micor D3: Radial resection margin, 2 frags,. Micor D4: Lymph node?, 1 frag,. Micro D5: Lymph node, 1 frag,. Micro D6: Lymph node, 2 frags,. Micro D7-D8: Ileal mesenteric mass, 1 frag,. Micro D9-D10: colonic mucosa, 4 frags. Micro D11-D14: Ileal mucosa, 8 frags,. Part E, "#5. Small bowel mesentery lymph node", consists of a lymph node of 1.3. x 0.5 x 0.5 cm with fibroadipose tissue measuring 2.0 x 1.0 x 1.0 cm in. aggregate. Micro E1: Lymph node and fibroadipose tissue, 3 frags,. By his/her signature below, the senior physician certifies that he/she. personally conducted a microscopic examination ("gross only" exam if so stated). of the described specimen (s) and rendered or confirmed the diagnosis (es). related thereto. Final Diagnosis by.
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TCGA-HT-A5R7.0C8ED6F2-0B6A-4316-A53C-EF42BCB47E39
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MR# : ACCT# : LOC : DOCTOR: ADDENDUM NEUROPATHOLOGY REPORT. ADDENDUM DISCUSSION: The neoplastic cells express IDH1 but are negative for p53 . Numerous MIB-1. reactive cella are present with a labeling index of 12.48. ADDENIOUM DIAGKOSIS: 1-3. Right parietal tumor, including enhancing nodule, biopsy resection: Anaplastic astrocytoma (grade III). -- MIB-1 LI - 12.4%. ADDENDUN CPT copes,. ACCESSION#: . NEUROPATHOLOGY REPORT. SPECIMEN SOURCE: 1. Right parietal tumor FS. 2. Enhancing nodule FS. 3. Right parietal tumor perm. CLINICAL DIAGNOSIS: Brain tumor. GROSS DESCRIPTION: 1. Received fresh for frozen section, labeled with the patient's name and. "right parietal tumor,' is an irregular portion of tan-white and hemorrhagic. soft tissue measuring 1.5 x 1.5 x 0.5 cm. A smear is performed and the entire. specimen is frozen as F1 A. Frozen section diagnosis: Infiltrating glioma, favor high grade. The tissue block is subsequently submitted for permanent sectioning. DATE COLLECTED: PAGE: 1. DATE RECEIVED: CONTINUED. ANATOMIC RATHOI DGV REPORT. MR # : ACCT# : LOC : DOCTOR: NEUROPATHOLOGY REPORT. GROSS DESCRIPTION: 2. Received fresh for frozen section, labeled with the patient's name and. . enhancing nodule, is a polypoid portion of tan orange soft tissue measuring. 0.7 x 0.5 x 0.5 cm. A smear is performed the entire specimen is frozen as. F2A. Frozen section diagnosis. High-grade glioma. The tissue block is subsequently submitted for permanent sectioning. 3. Received in formalin, labeled with the patient's name and "right parietal. tumor perm, are multiple irregular fragments of tan-white to red soft tisaue. measuring in aggregate to 3.0 x 2.0 x 0.6 cm. The entire specimen is. submitted in cassettes 3A to 3B. MICROSCOPIC DESCRIPTION: 1-3. Sections demonstrate a diffusely infiltrative astrocytic neoplasm. Atypia ranges from mild to marked. Cellularity has a similar range. Most. of. the tumor cells resemble fibrillary or gemistocytic astrocytes Some cells. lack obvious processes and there is a suggestion of perinuclear halos but the. overall phenotype of the tumor appears to be astrocytoma. Microvascular. proliferation and necrosis are not seen. Unfortunately, specimens one and. two. are the most cellular. These demonstrate only an occasional mitosis an the. frozen section artifact makes identification difficult. DIAGNOSIS: (Provisional). 1-3. Right parietal tumor, including enhancing nodule, biopay and resection: Consistent with anaplastic astrocytoma, pending additional studies. CPT. CPT. DATE COLLECTED: PAGE: 2. DATE RECEIVED: - END OF REPORT -.
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TCGA-98-A539.9CC9A747-F186-4BAE-B63F-82DC061B06FA
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Observation Date. Last Edited Date. Diagnosis. A. Tonsil, left, biopsy: - Negative for malignancy. B. Lymph node, 7, excision: - Negative for malignancy. C. Lymph node, 9, excision:- Negative for malignancy. D. Lymph node, 8, excision: - Negative for malignancy. E. Lymph node, 11-L: - Negative for malignancy.,. F. Lymph node, level 5, excision: - Negative for malignancy. G. Lymph node, level 6, excision: Negative for malignancy. H. Soft tissue, anterior margin between ribs 4 and 5, excision: Negative for malignancy. I. Soft tissue, anterior margin from rib 3, excision: - Negative for malignancy. J. Soft tissue, extrathoracic, excision: Squamous cell carcinoma. K. Soft tissue, posterior margin rib 3, biopsy: - Negative for malignancy. L. Soft tissue, serratus muscle, biopsy:- Positive for squamous cell carcinoma. M. Soft tissue, second rib, excision: - Positive for invasive squamous cell carcinoma within the marrow aspect of the. bony tissue. N. Soft tissue, intercostal muscle between ribs 1 and 2, excision: - Squamous cell carcinoma present. O. Soft tissue, middle scalene muscle, excision: - Positive for squamous cell carcinoma. P. Lung, left upper lobe wedge and parts of ribs 2 and 3, excision: - Squamous cell carcinoma (4.5 cm). - Negative. margins at staple line. - Pleura is uninvolved. - Lymph nodes are negative, please see detailed list. Q. Pleura, biopsy: - Negative for malignancy. R. Lymph node, 5, excision: - Negative for malignancy. pT3, NO, Mx. Clinical Information: The patient is E. year-old male with lung cancer. Frozen Section Diagnosis. A1: Tonsil, left, biopsy: - Negative for malignancy. B1: Lymph node, #7, excision:- Negative for malignancy. C1: Lymph node, #9, excision: - Negative for malignancy. D1: Lymph node, #8, excision: - Negative for malignancy. F1: Lymph node, level 5, excision: - Negative for malignancy. G1: Lymph node, level 6, excision: - Negative for malignancy. H1: Soft tissue, anterior margin between ribs 3 and 4, excision: - Negative for malignancy. J1: Soft tissue, extrathoracic, excision: - Squamous cell carcinoma. K1: Soft tissue, posterior margin rib 3, biopsy:- Negative for malignancy. L1: Soft tissue, part of serratus muscle, biopsy: - Positive for squamous cell carcinoma. P1: Lung, left upper lobe wedge and part of ribs 2 and 3, excision: - Tumor grossly 0.5 cm from the nearest staple. line margin. (all per. Gross Description. The specimen is received in eighteen containers, each labeled with the patient's name and medical record number. The first container is further labeled "biopsy of tonsil." Specimen is received fresh in frozen, now in formalin, and contains. one pink fragment of tissue measuring 0.5 x 0.5 x 0.5 cm. It contains a cassette containing material for previous. evaluation. The tissue is resubmitted entirely in cassette A1. The second container is labeled "level 7." Specimen is received fresh in the frozen room, now in formalin, and. contains a cassette containing previous material for previous frozen evaluation which measures 0.5 x 0.5 x 0.2 cm. Specimen is submitted entirely in cassette B1. The third container is labeled "lymph node #9." Specimen is received fresh in frozen room, now in formalin, and. contains a cassette containing material for previous frozen evaluation which measures 1.5 x 1.0 x 0.3 cm. Specimen is. entirely submitted in cassette C1. The fourth container is labeled "lymph node #8." Specimen is received fresh in frozen room, now in formalin, and. contains a cassette containing material for previous frozen evaluation measuring 1.0 x 0.6 x 0.3 cm. Specimen is entirely. submitted in cassette D1. The fifth container is labeled "lymph node #11-L." It contains a dark brown color irregular shape soft tissue. measuring 1.0 x0.8 x 0.3 cm. Specimen is entirely submitted in cassette E1. The sixth container labeled "level 5 lymph node." The specimen is received fresh in frozen room, now in formalin,. and contains a cassette containing material for previous frozen evaluation which measures 1.0 x 0.8 X 0.2 cm. Specimen. is submitted entirely in cassette F1. The seventh container is labeled "level 6 lymph node." The specimen is received fresh in frozen room, now in. formalin, and contains a cassette containing material for previous frozen evaluation measuring 2.5 x 1.0 x 0.2 cm. Specimen is submitted entirely in cassette G1. The eighth container is labeled "anterior margin between ribs 4 and 5." Specimen is received fresh in frozen room,. now in formalin, and contains red tissue measuring 0.8 X 0.7 x 0.2 cm. Specimen is submitted entirely in cassette H1. The ninth container is labeled "anterior margin from rib 3." It contains a bone and soft tissue measuring 1.2 x 1.2 x. 0.3 cm. The submitted is submitted entirely in cassette I1 after decalcification. The tenth container is labeled "extrathoracic tissue." It contains a specimen received fresh in frozen room, now in. formalin, and contains one cassette containing material for previous frozen evaluation measuring 1.5 x 1.2 x 0.3 cm. Specimen is resubmitted entirely in cassette J1. The eleventh container is labeled "posterior margin of rib 3." Specimen is received fresh in frozen room, now in. formalin, and contains a cassette containing material for previous frozen evaluation which measures 0.8 x 0.6 x 0.2 cm. Specimen is resubmitted entirely in cassette K1. The tweifth container is labeled "part of serratus muscle." Specimen is received fresh in the frozen room, now in. formalin, and contains a cassette containing material from previous frozen revaluation which measures 3.5 X 2.5 x 0.3 cm. Specimen is resubmitted entirely in cassette L1. The thirteen container is labeled "part of second rib." It contains a piece of rib measuring 6 x 2 x 1.5 cm. It contains. muscle and part of the bone. The specimen is submitted entirely in cassette M1-M10 after decalcification. The fourteen container is labeled "intercostal muscle between ribs 1 and 2." It contains a piece of pink-red. fibroadipose tissue measuring 3.0 X 2.2 X 1.3 cm. Specimen is not oriented. Serial sectioning reveals pink-red-tan. surface. Specimen is submitted entirely in cassettes N1-N5. The fifteen container is labeled "middle scalene muscle." It contains a piece of pink-red tissue measuring 2.7 X 1.8 X. 1.5 cm. Specimen is not oriented. Surgical margin will be inked black. Serial sectioning reveals pink-red cutting surface. Representative sections of the specimen will be submitted entirely O1-05. The sixteen container is further labeled left upper lobe wedge and part of ribs 2 and 3." It contains a lung wedge. biopsy with attached chest wall and rib. The lung measuring 12.0 X 7.5 x 2.5 cm and the chest wall measuring 11.0 X 7.5 X. 2.0 cm. Staple line margin is identified measuring 12.0 cm in length. The staple line is shaved and inked black. Serial. sectioning through the lung wedge reveals a tan-white necrotic tumor measuring 4.5 cm in greatest dimension and. approximately 0.5 cm from the inked margin anterior invades deep into the chest wall and right abuts the outer surface. The entire outer surface of the chest will be inked green. The tumor appears to involve the anterior and part of the chest. wall, lateral margin. However, the superior end inferior margin cannot be clear oriented. The tumor is approximately 1.1. cm from the lateral margin. Representative sections will be submitted per block summary. The seventeen container is labeled "pleura." It contains a piece of bone with associated soft tissue measuring 2.5 X. 2.0 x 0.8 cm. Specimen is submitted after decalcification. The eighteen container labeled "lymph node #5." It contains one pink-red fibroadipose tissue measuring 1.3 X 1.0 x. 0.5 cm. Specimen is serially sectioned submitted entirely in cassette R1. Block Summary. A1-. Biopsy tonsil. B1-. Lymph node 7. C1-. Lymph node 9. D1-. Lymph node 8. E1-. Lymph node 11-L. F1-. Lymph node 5. G1-. Lymph node 6. H1-. Anterior margin between ribs 4 and 5. Anterior margin from rib 3. J1-. Extrathoracic tissue. K1-. Posterior margin, rib 3. L1-. Part of serratus muscle. M1-M10. Part of 2nd rib. N1-. Intercostal muscle between ribs 1 and 2. O1-O5. Middle scalene muscle. P1-P2. Tumor related to the inked staple margin. P3-. Representative sections of tumor. P4-P5. Tumor related to the anterior margin. P6-P7. Tumor related to the lateral margin. P8-. Uninvolved lung. P9-. Superior inferior margin. Q1-Q2. Pleura. R1. Lymph node #5. Microscopic Description. A microscopic examination has been performed.
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TCGA-BH-A0HA.E6C20D27-63E5-4FFF-96BF-E8BD71296925
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FINAL DIAGNOSIS: PART 1: BREAST, RIGHT, TOTAL MASTECTOMY -. A. B. INVASIVE LARGEST DUCTAL TUMOR (MASS CARCINOMAS #1): NOTTINGHAM (3). GRADE Il (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM. 2, SECOND LARGEST TUMOR (MASS #2): NO TINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR. MITOTIC ACTIVITY 1; TOTAL SCORE 6/9). c. PLEOMORPHISM 3, MITOTIC ACTIVITY 1; TOTAL SCORE 7/9). D. SMALLEST TUMOR (MASS #3): NOTTINGHAM GRADE II (TUBULE FORMATION 3, NUCLEAR. PLEOMORPHISM 2, MITOTIC ACTIVITY 1; TOTAL SCORE 6/9). is. INVASIVE TUMORS MEASURE 1.3 CM (SLIDE 1D), 0.8 CM. AND 0.5 CM l. E. DUCTAL CARCINOMA IN-SITU (DCIS), NUCLEAR GRADE 2, SOLID PATTERN. G. F. DCIS CONSTITUTES 10% OF THE TOTAL TUMOR MASS AND IS PRESENT ADMIXED WITH AND AWAY. FROM THE INVASIVE COMPONENT. H. LOBULAR CARCINOMA IN-SITU (LCIS) IS ALSO IDENTIFIED. I. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED. J. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA. K. INVASIVE CARCINOMA IS 0.5 CM FROM THE NEAREST ANTERIOR MARGIN. L. DUCTAL CARCINOMA IN-SITU IS 0.5 CM FROM THE NEAREST ANTERIOR MARGIN. M. NIPPLE IS NEGATIVE FOR TUMOR. N. NON-NEOPLASTIC BREAST TISSUE SHOWS NON-PROLIFERATIVE FIBROCYSTIC CHANGES. O. BIOPSY SITE CHANGES. P. INVASIVE TUMOR CELLS (MASS #1) TESTED POSITIVE FOR ESTROGEN AND PROGESTERONE. RECEPTORS AND NEGATIVE FOR HER-2 AS PER PREVIOUS PATHOLOGY REPORT. PART 2: LYMPH NODE, RIGHT, SENTINEL NODE #1, BIOPSY -. NO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE LYMPH NODE (0/1). PART 3: BREAST, RIGHT, SENTINEL NODE #2, BIOPSY -. NO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN TWO LYMPH NODES (0/2). PART 4: LYMPH NODE, RIGHT, SENTINEL NODE #3, BIOPSY -. NO METASTATIC MAMMARY CARCINOMA IDENTIFIED IN ONE LYMPH NODE (0/1). PART 5: BREAST, LEFT, TOTAL MASTECTOMY -. A. NIPPLE WITH NO EVIDENCE OF PAGET'S DISEASE. B. BENIGN BREAST PARENCHYMA WITH NON-PROLIFERATIVE FIBROCYSTIC CHANGES. CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST. LATERALITY: Right. PROCEDURE: Simple mastectomy. Site: breast, NOS C50-9 3/0/11 her. Not specified. SIZE OF TUMOR: Maximum dimension invasive component: 1.3 cm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR AGGREGATE SIZE: Sum of the sizes of multiple invasive tumors: 2.6 cm. TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS. NOTTINGHAM SCORE: Nuclear grade: 2. Tubule formation: 3. Mitotic activity score: 1. Total Nottingham score: 6. Nottingham grade (1, 2, 3): 2. ANGIOLYMPHATIC INVASION: DERMAL LYMPHATIC INVASION: CALCIFICATION: TUMOR TYPE, IN SITU: Solid. SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: Distance of invasive tumor to closest margin: 5 mm. SURG MARGINS INVOLVED BY IN SITU COMPONENT: Distance of in situ disease to closest margin: 5 mm. PAGET'S DISEASE OF NIPPLE: LYMPH NODES POSITIVE: o. LYMPH NODES EXAMINED: 4. METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain. SENTINEL NODE METASTASIS: NON-NEOPLASTIC BREAST TISSUE: FCD. T STAGE, PATHOLOGIC: pT1c. N STAGE, PATHOLOGIC: pNO(i-). M STAGE, PATHOLOGIC: pMX. ESTROGEN RECEPTORS: positive. PROGESTERONE RECEPTORS: positive. HER2/NEU: zero or 1+.
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TCGA-CV-6003.6ae06a67-bac0-4884-a7a8-aca62cc81074
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DIAGNOSIS. (A) LEFT PARTIAL GLOSSECTOMY: DEEPLY INVASIVE SQUAMOUS CARCINOMA, MODERATELY DIFFERENTIATED (2.8 CM). No perineural invasion or lymphovascular invasion identified. Surgical margins of resection. no tumor preset. Growth: Ulcerating,. (B) LEFT SUPRAOMOHYOID NECK DISSECTION LEVEL I: Six lymph nodes, no tumor present (0/6). (C) LEFT SUPRAOMOHYOID NECK DISSECTION LEVEL II: One lymph node, no tumor present (0/1). (D) LEFT SUPRAOMOHYOID NECK DISSECTION LEVEL III: MICROSCOPIC FOCUS OF CARCINOMA (SUBCAPSULAR) IN ONE OF SIXTEEN LYMPH NODES (1/16). (E) TOOTH #5: Tooth, gross examination only. Entire report and diagnosis completed by. GROSS DESCRIPTION. (A) LEFT PARTIAL GLOSSECTOMY - One partial glossectomy (9.6 X 3.2 x 0.9 cm) is oriented by suture single stitch for. anterior, double stitch for dorsal surface, One ulcerated tumor (2.8 x 1.5 x 1.0 cm) is 0.3 cm away from closest anterior margin. The specimen is entirely submitted in thirteen cassettes. (some tissue submitted for tissue bank). INK CODE: Black - anterior with deep margin area. SECTION CODE: A1, A2, anterior and deeper margin for frozen section: A3, inferior margin en face; A4, posterior. margin en face; A5. dorsal margin en face; A6-A12, rest of tumor and surrounding tissue from anterior to posterior. circumferences. FS/DX: FAVOR SQUAMOUS CELL CARCINOMA, MARGIN IS FREE. (B) LEFT SUPRAOMOHYOID NECK DISSECTION LEVEL | - Received is a portion of yellow-tan fibrofatty adipose tissue. including submandibular gland and a short segment of venous tissue measuring 6.8 X 3.5 X 1.6 cm. The submandibular gland. measures 3.6 x 3.2 X 1.5 cm. The venous structure measures approximately 3.5 cm in length and 0.2 cm in diameter. Submandibular gland is step sectioned at close intervals revealing no gross abnormalities. The venous structure section. revealing no evidence of tumor. The remainder of the tissue is dissected revealing six possible lymph nodes that range from. 0.4 to 0.8 cm. Representative sections are submitted in cassette B1-B9. SECTION CODE: B1, ends of venous tissue; B2-B4, representative sections of submandibular gland; B5, highest. lymph. node. unsectioned: B6, single node bisected: B7, single node sectioned; B8, two small lymph nodes; B9, lowest lymph. node unsectioned. (C) LEFT SUPRAOMOHYOID NECK DISSECTION, LEVEL II - Received is a portion of yellow-tan fibrofatty adipose tissue. measuring 3.2. x 1.8 X 1.9 cm. There is a short segmented attached portion of venous tissue measuring 1.4 cm in length and. 0.3 cm in diameter. The venous tissue reveals no evidence of tumor Four possible lymph nodes are identified on sectioning. the adipose tissue that range from 0.3 to 0,4 cm, Representative sections are submitted in cassettes C1 and C2. SECTION CODE: C1, sections of venous tissue; C2, four small lymph nodes. (D) LEFT SUPRAOMOHYOID NECK DISSECTION, LEVEL III - Received is a portion of yellow-tan fibrofatty adipose tissue. measuring 3.2 X 2.2 x 1.8 cm. The tissue was dissected revealing seventeen possible lymph nodes that range from 0,4 to 1.7. cm. Representative sections are submitted in cassette D1-D8. SECTION CODE: D1, four small lymph nodes; D2, four small lymph nodes; D3, four small lymph nodes; D4, single. node bisected; D5, single node trisected; D6. single node trisected; D7, single node sectioned; D8, single node sectioned. (E) TOOTH #5 - Received is a tooth 1.6 X 0.9 x 0.8 cm. Specimen submitted for gross only. CLINICAL HISTORY. The patient has a history of oral cancer. SNOMED CODES. T-53000, T-C4200, M-80703. "Some tesls reported here may have been developed and performance characenstes determined b. Pathology and Laboratory Medicine These tests have not been specifically cléared nr. approved by the U.S Food and Drog Administration. Released by.
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TCGA-HV-A5A6.6C6BDA2E-3A76-4EEB-99FB-6D1C4B8D5DBF
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Pancreas Cancer. <Slide key: A: pancreatic resection margin, B. #13, C: LN #14, D: omentum,. E: LN #5, F: LN #8, G: LN #12, H: LN 13#, 1: LN 16#, 1: 2-5: duodenum. (2: ampulla of vater, 3. 6: duodenum. 7-8: CBD. 9: CBI. 0-11: GB. (10: CBD opening. , 12: 13: ampulla of vater. MICRO (25HE). DIAGNOSIS: Head of pancreas, duodenum, common bile duct and gallbladder,. pylorus-preserving pancreat ticoduodenectomy: Ductal adenocarcinoma, well differentiated, pancreas. with 1) tumor size: 3.5x2.3cm. 2) extension to per ipancreatic soft tissue. 3) invasion to duodenum, common bile duct and ampulla of Vater. 4) perineural invasion, multifocal. 5) venous invasion: not identified. 6) clear pancreatic, common bile duct and duodenal resection margins. 7) metastasis to two out of 22 regional Tymph nodes. (LN #13: 0/4, LN #14: 0/1, LN #5: 0/0, LN #8: 0/2, LN #12: 0/11,. LN #16: 0/13, per ipancreatic LN: 1/1). 8) pathologic staging: pT3 N1b.
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TCGA 病理報告書データ（英語自由記述）
このデータセットは、The Cancer Genome Atlas (TCGA) により公開された英語の病理報告書です。 huggiingfaceアップロード用にファイル形式の変換とカラム名の修正を行っています。
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TCGA Pathology Reports (Version 1)
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