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| license: cc-by-4.0 |
| tags: |
| - biology |
| - rna |
| - genomics |
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| # Overview |
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| Mean Ribosome Load (MRL) measures the mean number of ribosomes attached to a given transcript. This dataset is collected from Sugimoto and Ratcliffe 2022, where MRL measurements are made in human kidney cancer cells. Importantly, this dataset is isoform-resolved, providing measurements at an isoform level. |
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| This dataset is redistributed as part of mRNABench: https://github.com/morrislab/mRNABench |
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| # Data Format |
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| Description of data columns: |
| - `target`: Mean ribosome load for transcript. |
| - `cds`: Binary track which reports position of first nucleotide in each codon in CDS. |
| - `splice`: Binary track which reports position of the 3' end of each exon, indicating splice sites. |
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| # Data Source |
| This dataset is generated using the data collected in Sugimoto and Ratcliffe 2022, which is licensed under the Creative Commons Attribution 4.0 International License. |
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| Original paper: https://www.nature.com/articles/s41594-022-00819-2 |
| Original dataset source: https://www.nature.com/articles/s41594-022-00819-2#Sec63 |
| Citation: Sugimoto, Y. & Ratcliffe, P. J. Isoform-resolved mRNA profiling of ribosome |
| load defines interplay of HIF and mTOR dysregulation in kidney cancer. Nature |
| Structural Molecular Biology 29, 871–880 (2022). |
