_id stringlengths 12 15 | text stringlengths 31 46.6k | title stringclasses 1
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PMC10773625_5 | In conclusion, COVID-19 vaccination may induce hypophysitis directly or indirectly. We should carefully observe the adverse reactions after vaccine injection and evaluate endocrine function if necessary, especially in patients with severe hyponatremia and hypotension to early recognize the rare but serious adverse reac... | |
PMC11790522_0 | Variants within this domain are known to increase EP300 acetyltransferase activity and p53 acetylation, potentially contributing to cancer in some RSTS2 patients [8]. | |
PMC11790522_4 | This research underscores the necessity for comprehensive genetic screening in patients with complex Rubinstein–Taybi syndrome (RSTS) phenotypes, potentially uncovering novel variants in CREBBP and EP300. Such an approach enables early, proactive management and informed decisions, potentially mitigating the disease's i... | |
PMC11587613_0 | This condition underscores the critical role of IRP2 in maintaining iron metabolism and mitochondrial function, with disruptions leading to severe neurological and hematological manifestations. | |
PMC11587613_1 | Functional analyses using patient-derived cells and SH-SY5Y cell lines overexpressing mutant IRP2 revealed significant degradation of the IRP2 protein in the presence of the A2477T mutation. This degradation was associated with altered expression of iron metabolism-related proteins, notably increased FTH and decreased ... | |
PMC11587613_2 | Previous studies have highlighted the role of IRP2 in regulating the metabolic switch from glycolysis to oxidative phosphorylation by stabilizing hypoxia-inducible factors. Our results further support the hypothesis that IRP2 degradation plays a pivotal role in the disease mechanism, as evidenced by the restoration of ... | |
PMC11539628_0 | The incidence of aortic pseudoaneurysm following TAVI is rare, and there is limited data available regarding its occurrence, with only a few reported cases in the literature [3–5]. Regarding the incidence of endocarditis, there is no significant difference between TAVI and conventional surgery, although there have been... | |
PMC11539628_1 | The development of aortic pseudoaneurysms is commonly associated with intimal lesions in the aorta, resulting in bleeding and hematoma formation between the vessel walls. However, in some cases, it can occur as a secondary consequence of local infections [6]. | |
PMC11539628_2 | While there are reports of endovascular repair of pseudoaneurysms after TAVI, the presence of an associated fungal infection necessitated valve replacement to address the contaminated valve [7]. Despite the patient’s high surgical risk, the decision to proceed with the surgical procedure was made due to the high mortal... |
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