query stringlengths 16 148 | pos stringlengths 16 855 | neg stringlengths 0 2.05k | idx int64 0 132k | task_name stringclasses 1
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Too Many Detectives [SEP] characters | Too Many Detectives
"Too Many Detectives" is a Nero Wolfe mystery novella by Rex Stout, first published September 14, 1956, in "Collier's". It first appeared in book form in the short-story collection "Three for the Chair", published by the Viking Press in 1957.
Plot summary.
Nero Wolfe and Archie Goodwin have been sum... | the Morgue" is not out of print; he attributes this to "catering to SF fans’ egos." Nicoll also posited that the inspiration for the character of Hilary involved "naked Martian princesses and well-known consulting detectives."
The Heinlein Society felt that "(a)s a mystery novel, (it) falls a bit short", and it has "to... | 7,300 | zeroshot-train |
Tora Torapa [SEP] characters | Tora Torapa
Tora Torapa, written and drawn by Fournier, is the twenty-third album of the "Spirou et Fantasio" series, and the author's fourth, following the "Spirou" retirement of André Franquin. The story was initially serialised in "Spirou" magazine before its publication as a hardcover album in 1973.
Story.
In "Tora... | Recurring characters Ororéa Appearances.
- 23. "Tora Torapa" (Fournier)
- 25. "Le gri-gri du Niokolo-Koba" (Fournier)
- 27. "L'Ankou" (Fournier)
- 30. "Des haricots partout" (Fournier) (Note: she appears only on the last/final page)
Recurring characters Roulebille.
Recurring characters Roulebille Appearances.
- 4. "Spi... | 7,301 | zeroshot-train |
Trio for Blunt Instruments [SEP] characters | Trio for Blunt Instruments
Trio for Blunt Instruments is a collection of Nero Wolfe mystery novellas by Rex Stout, published in 1964 by the Viking Press in the United States and simultaneously by MacMillan & Company in Canada. The book comprises three stories:
- "Kill Now—Pay Later", serialized in three issues of "The ... | 2006, "Firsts: The Book Collector's Magazine" estimated that the first edition of "Trio for Blunt Instruments" had a value of between $150 and $300. The estimate is for a copy in very good to fine condition in a like dustjacket.The "concept-driven" dustjacket designed by Bill English was cited by graphic design scholar... | 7,302 | zeroshot-train |
Triple Jeopardy [SEP] characters | Triple Jeopardy
Triple Jeopardy is a collection of Nero Wolfe mystery novellas by Rex Stout, published by the Viking Press in 1952. Itself collected in the omnibus volume "Kings Full of Aces" (Viking 1969), the book comprises three stories that first appeared in "The American Magazine":
- "Home to Roost" (January 1952,... | Nov 1998
- 3rd : Joan Richter, "Recipe Secrets", Sep-Oct 1998
Recipients 1997.
- 1st : Jeffery Deaver, "Double Jeopardy", Sep-Oct 1997
- 2nd : Doug Allyn, "Copperhead Run", Jun 1997
- 3rd : George C. Chesbro, "The Problem with the Pigs", Jun 1997
Recipients 1996.
- 1st : Doug Allyn, "Roadkill", May 1996
- 2nd : Doug Al... | 7,303 | zeroshot-train |
Trouble in Triplicate [SEP] characters | Trouble in Triplicate
Trouble in Triplicate is a collection of Nero Wolfe mystery novellas by Rex Stout, published by the Viking Press in 1949, and itself collected in the omnibus volume "All Aces" (Viking 1958). The book contains three stories that first appeared in "The American Magazine":
- "Before I Die" (April 194... | 1976
Publication history "Trouble in Triplicate".
- 1949, New York: The Viking Press, February 11, 1949, hardcover
- 1949, Toronto: Macmillan, 1949, hardcover
- 1949, New York: Viking (Mystery Guild), August 1949, hardcover
- 1949, London: Collins Crime Club, August 22, 1949, hardcover
- 1951, New York: Bantam #925, Se... | 7,304 | zeroshot-train |
Two for the Lions [SEP] characters | Two for the Lions
Two for the Lions is a 1998 historical mystery crime novel by Lindsey Davis and the 10th book of the Marcus Didius Falco Mysteries series. Set in Rome and Tripolitania between December AD 73 and May AD 74, during the reign of Emperor Vespasian, the novel stars Marcus Didius Falco, informer and imperia... | was called up by the team and played two Tests. Originally chosen as a replacement wing he then took over as fullback after a spate of injuries to the touring party. He played his final match for the British Lions on 20 Sep 1924 at Newlands Stadium and scored a try in that final match that was rated as the best of the ... | 7,305 | zeroshot-train |
Venus in Copper [SEP] characters | Venus in Copper
Venus in Copper is a 1991 historical mystery crime novel by Lindsey Davis and the third book of the Marcus Didius Falco Mysteries series. Set in Rome during AD 71, just after the year of the four emperors, the novel stars Marcus Didius Falco, informer and imperial agent. The copper of the title refers t... | Mason
- "Severina Zotica" - Suspect 'professional bride' with three deceased husbands.
- "Thalia" - Exotic dancer and snake charmer
- "Tyche" - Fortune-teller
- "Viridovix" - Gallic chef
Characters in "Venus in Copper" Death toll.
- "Hortensius Novus" - Found dead on the privy after being poisoned.
- "Viridovix" - Pois... | 7,306 | zeroshot-train |
Vito la Déveine [SEP] characters | Vito la Déveine
Vito la Déveine, written by Tome and drawn by Janry, is the forty-third album of the "Spirou et Fantasio" series, and the eleventh album created by the authors. The story was serialised in "Spirou" magazine before it was released as a hardcover album in 1991.
Story.
After the intervention of Spirou and ... | 43. "Vito la Déveine" ("Bad Luck Vito", 1991)
- 44. "Le rayon noir" ("The Black Ray", 1993)
- 45. "Luna fatale" (1995)
- 46. "Machine qui rêve" ("Dreaming machine", 1998)
Albums Morvan & Munuera.
- 47. "Paris-sous-Seine" ("Paris-under-Seine", 2004)
- 48. "L'homme qui ne voulait pas mourir | 7,307 | zeroshot-train |
Watchmen [SEP] characters | the Vietnam War and the presidency of Richard Nixon. In keeping with the realism of the series, although the costumed crimefighters of "Watchmen" are commonly called "superheroes", only one, named Doctor Manhattan, possesses any superhuman abilities. The war in Vietnam ends with an American victory in 1971 and Nixon is... | Watchmen
Watchmen is an American superhero comic book maxiseries by the British creative team of writer Alan Moore, artist Dave Gibbons and colorist John Higgins. It was published by DC Comics in 1986 and 1987, and collected in a single volume edition in 1987. "Watchmen" originated from a story proposal Moore submitted... | 7,308 | zeroshot-train |
When a Man Murders [SEP] characters | When a Man Murders
"When a Man Murders" is a Nero Wolfe mystery novella by Rex Stout, first published in the May 1954 issue of "The American Magazine". It first appeared in book form in the short-story collection "Three Witnesses", published by the Viking Press in 1956.
Plot summary.
Sidney Karnow has returned from the... | to perform the murders, and Battler Ushiromiya, a young man who argues that the murders could be carried out by ordinary humans. As a tag-team game, the game's story mode follows multiple pairs of characters, each of which has their own story and ending that take place in an alternate continuity from "Umineko When They... | 7,309 | zeroshot-train |
Wolf's Bane [SEP] characters | Wolf's Bane
Wolf's Bane is the nineteenth book in the Lone Wolf book series created by Joe Dever and now illustrated by Brian Williams.
Gameplay.
Lone Wolf books rely on a combination of thought and luck. Certain statistics such as combat skill and endurance attributes are determined randomly before play. The player is... | Leopard's bane
Leopard's bane or leopard's-bane may refer to:
- "Aconitum", also known as aconite, monkshood, wolf's bane, women's bane, Devil's helmet or blue rocket, a genus of flowering plants belonging to the buttercup family
- "Arnica montana", also known as wolf's bane, mountain tobacco and mountain arnica, a Eur... | 7,310 | zeroshot-train |
Wuthering Heights [SEP] characters | and recuperation, rents Thrushcross Grange in Yorkshire. He visits his landlord, Heathcliff, who lives in a remote moorland farmhouse, Wuthering Heights. There Lockwood finds an odd assemblage: Heathcliff, who seems to be a gentleman, but whose manners are uncouth; the reserved mistress of the house, who is in her mid-... | Wuthering Heights (1939 film)
Wuthering Heights is a 1939 American romantic period drama film directed by William Wyler and produced by Samuel Goldwyn. It is based on the novel, "Wuthering Heights", by Emily Brontë. The film depicts only sixteen of the novel's thirty-four chapters, eliminating the second generation of ... | 7,311 | zeroshot-train |
Wyrd Sisters [SEP] characters | Wyrd Sisters
Wyrd Sisters is Terry Pratchett's sixth "Discworld" novel, published in 1988, and re-introduces Granny Weatherwax of "Equal Rites".
Plot.
"Wyrd Sisters" features three witches: Granny Weatherwax; Nanny Ogg, matriarch of a large tribe of Oggs and owner of the most evil cat in the world; and Magrat Garlick, ... | a 1948 British film
- Three Weird Sisters (band), a filk band based in Atlanta, Georgia
- The Weird Sisters, Prudence, Agatha & Dorcas, characters from "Chilling Adventures of Sabrina".
See also.
- Wyrd Sisters, a Discworld novel by Terry Pratchett
- Wyrd Sisters (band), a Canadian folk group | 7,312 | zeroshot-train |
Z comme Zorglub [SEP] characters | Z comme Zorglub
Z comme Zorglub, written and drawn by Franquin, is the fifteenth album of the "Spirou et Fantasio" series, and the first part of Franquin's Zorglub diptych. The story was initially serialised in "Spirou" magazine before its release as a hardcover album in 1961.
Story.
In "Z is for Zorglub", Fantasio rec... | - 55. "La colère du Marsupilami" (Yoann & Vehlmann)
Recurring characters Zorglub.
Zorglub was created by Greg and Franquin, and first appeared in the story "Z comme Zorglub" serialised in 1959, published in the diptych albums "Z comme Zorglub" (1961) and "L'ombre du Z" (1962). Initially Zorglub's character was that of ... | 7,313 | zeroshot-train |
Zero Minus Ten [SEP] characters | Zero Minus Ten
Zero Minus Ten, published in 1997, is the first novel by Raymond Benson featuring Ian Fleming's James Bond following John Gardner's departure in 1996. Published in the United Kingdom by Hodder & Stoughton and in America by Putnam, the book is set in Hong Kong, China, Jamaica, England, and some parts of W... | mode, a password is shown to allow player to register the game result through the game's Internet ranking site.
4-player versus modes (from Shooting Love. 200X) is a 4-player variant of the promotion game title Shooting Love. 8, and adds a test category.
Games Minus Zero.
Minus Zero is an endless shooter with abstract ... | 7,314 | zeroshot-train |
ABCA13 [SEP] chromosome | ABCA13
ATP-binding cassette sub-family A member 13 also known as ABCA13 is a protein that in humans is encoded by the "ABCA13" gene on chromosome 7. It belongs to the wide ATP-binding cassette family of proteins. The protein contains 5058 residues, and is currently the largest known protein of the ABC family.
Clinical ... | first subgroup consists of seven genes that map to six different chromosomes. These are ABCA1, ABCA2, ABCA3, and ABCA4, ABCA7, ABCA12, and ABCA13. The other subgroup consists of ABCA5 and ABCA6 and ABCA8, ABCA9 and ABCA10. A8-10.
All of subgroup 2 is organized into a head to tail cluster of chromosomes on chromosome 17... | 7,315 | zeroshot-train |
ALOX15B [SEP] chromosome | arachidonic acid almost exclusively to the "S" stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the "S" stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the "S" stereoisomer of 13-... | ALOX15B
Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the "ALOX15B" gene. ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.
Function.
This gene encodes a member of the lipoxygenase family of structur... | 7,316 | zeroshot-train |
APOA4 [SEP] chromosome | APOA4
Apolipoprotein A-IV (also known as apoA-IV, apoAIV, or apoA4) is plasma protein that is the product of the human gene APOA4.
Gene.
APOA4 resides on chromosome 11 in close linkage to APOA1 and APOC3. APOA4 contains 3 exons separated by two introns, and is polymorphic, although most of the reported sequence polymor... | 347; a sequence polymorphism has also been identified in the 3'UTR of the third exon. Intra-species comparative gene sequence analysis suggests that the APOA4 gene arose from APOA1 by gene duplication approximately 270 MYA.
Function.
The primary translation product of the APOA4 gene is a 396-residue preprotein, which u... | 7,317 | zeroshot-train |
ASH1L [SEP] chromosome | Hox gene expression and body segment identity. Drosophila Ash1 interacts with trithorax to regulate ultrabithorax expression.
The human ASH1L gene spans 227.5 kb on chromosome 1, band q22. This region is rearranged in a variety of human cancers such as leukemia, non-Hodgkin’s lymphoma, and some solid tumors. The gene i... | both MLL1 and ASH1L for activation, whereas MLL1 or ASH1L alone are not sufficient to activate transcription. The methyltransferase activity of ASH1L is not required for Hox gene activation but instead has repressive action. Knockdown of ASH1L in K562 cells causes up-regulation of the ε-globin gene and down-regulation ... | 7,318 | zeroshot-train |
Aldolase A [SEP] chromosome | Aldolase A
Aldolase A (ALDOA, or ALDA), also known as fructose-bisphosphate aldolase, is an enzyme that in humans is encoded by the "ALDOA" gene on chromosome 16.
The protein encoded by this gene is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate (... | , aldolase B is preferentially expressed in the liver, while aldolase A is expressed in muscle and erythrocytes and aldolase C is expressed in the brain. Slight differences in isozyme structure result in different activities for the two substrate molecules: FBP and fructose 1-phosphate. Aldolase B exhibits no preferenc... | 7,319 | zeroshot-train |
Aldolase C [SEP] chromosome | Aldolase C
Aldolase C, fructose-bisphosphate (ALDOC, or ALDC), is an enzyme that, in humans, is encoded by the "ALDOC" gene on chromosome 17. This gene encodes a member of the class I fructose-bisphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded prote... | , aldolase B is preferentially expressed in the liver, while aldolase A is expressed in muscle and erythrocytes and aldolase C is expressed in the brain. Slight differences in isozyme structure result in different activities for the two substrate molecules: FBP and fructose 1-phosphate. Aldolase B exhibits no preferenc... | 7,320 | zeroshot-train |
Autophagy-related protein 101 [SEP] chromosome | Autophagy-related protein 101
Autophagy-related protein 101 also known as ATG101 is a protein that in humans is encoded by the "C12orf44" gene (chromosome 12 open reading frame 44).
Autophagy is the process of forming a vacuole around proteins and nucleic acids that are to be broken down in lysosomes. The transcribed m... | ATG5
Autophagy related 5 (ATG5) is a protein that, in humans, is encoded by the "ATG5" gene located on Chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles. It is activated by ATG7 and forms a complex with ATG12 and ATG16... | 7,321 | zeroshot-train |
BCL2L13 [SEP] chromosome | BCL2L13
BCL2-like 13 (apoptosis facilitator), also known as BCL2L13 or Bcl-rambo, is a protein which in humans is encoded by the "BCL2L13" gene on chromosome 22. This gene encodes a mitochondrially-localized protein which is classified under the Bcl-2 protein family. Overexpression of the encoded protein results in apo... | mitochondrial permeability transition pore, to induce its opening. ANT will also facilitate the transfer of ADP and ATP between the cytosol and the matrix.
Clinical significance.
The BCL2L13 gene has been implicated in a wide spectrum of cancers. Previous clinical studies observed in ALL patients that high expression o... | 7,322 | zeroshot-train |
BRCA1 [SEP] chromosome | gene is located on the long (q) arm of chromosome 17 at region 2 band 1, from base pair 41,196,312 to base pair 41,277,500 (Build GRCh37/hg19) (map). "BRCA1" orthologs have been identified in most vertebrates for which complete genome data are available.
Protein structure.
The BRCA1 protein contains the following domai... | meiotic cells in which synapsis is defective. One such surveillance mechanism is meiotic silencing that involves the transcriptional silencing of genes on asynapsed chromosomes. Any chromosome region, either in males or females, that is asynapsed is subject to meiotic silencing. ATR, BRCA1 and gammaH2AX localize to uns... | 7,323 | zeroshot-train |
BRCA2 [SEP] chromosome | BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. "BRCA1" and "BRCA2" have been described as "breast cancer susceptibility genes" and "breast cancer susceptibility proteins". The predominant allele has a normal tumor suppressive function whereas high penetrance mutation... | knockout mice ["BRD7"(-/-)] are infertile and have higher levels of apoptosis and DNA damage in their germline cells.
Genetics Gene polymorphisms.
The human breast cancer susceptibility gene 2 ("BRCA2") is employed in DNA repair. A common single nucleotide polymorphism in "BRCA2" is associated with idiopathic male infe... | 7,324 | zeroshot-train |
Bcl-2 [SEP] chromosome | the Bcl-2 gene from chromosome 18 next to the immunoglobulin heavy chain locus on chromosome 14. This fusion gene is deregulated, leading to the transcription of excessively high levels of Bcl-2. This decreases the propensity of these cells for apoptosis.
Role in disease Auto-immune diseases.
Apoptosis plays an active ... | Bcl-2 homologous antagonist killer
Bcl-2 homologous antagonist/killer is a protein that in humans is encoded by the "BAK1" gene on chromosome 6. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are i... | 7,325 | zeroshot-train |
BinCARD [SEP] chromosome | BinCARD
Bcl10-interacting CARD protein, also known as BinCARD, is a protein that in humans is encoded by the "C9orf89" gene on chromosome 9. BinCARD is a member of the death-domain superfamily and contains a caspase recruitment domain (CARD). This protein regulates apoptosis and the immune response by inhibiting Bcl10,... | bundle. In humans, the protein has two alternatively spliced isoforms: BinCARD-1 and BinCARD-2. Both isoforms share identical sequences until residue 101, which include the CARD domain and exons 1 to 3. The longer isoform, BinCARD-1, has an extended exon 3, while the shorter BinCARD-2 has an extra transmembrane domain.... | 7,326 | zeroshot-train |
C10orf76 [SEP] chromosome | C10orf76
C10orf76 or chromosome 10 open reading frame 76, also known as UPF0668, is a protein that in humans is encoded by the "c10orf76" gene. Its function is not currently known, but experimental evidence has suggested that it may be involved in transcriptional regulation. The protein contains a conserved proline-ric... | Met416 of the largest protein variant).
Protein Structure.
The structure of the c10orf76 protein has not been experimentally explored. The secondary structure is predicted to be completely helical in nature, with intervening regions of protein disorder. The potential SH3-binding domain is located on a predicted region ... | 7,327 | zeroshot-train |
C11orf52 [SEP] chromosome | C11orf52
C11orf52 is an uncharacterized protein that in homo sapiens is encoded by the "C11orf52" gene.
Gene.
Gene Location.
C11orf52 is located on chromosome 11 at 11q23.1, starting at 111908620 and ending at 112064278. C11orf52 spans 155658 base pairs and is orientated on the positive strand. Gene C11orf52 has a mole... | can be found going back to Geospiza fortis - the most distantly related to "Homo Sapiens" C11orf52 sequence. Gene duplication first occurred approximately 324.5 million years ago in reptiles and birds. There are no paralogs for the C11orf52 gene.
Clinical significance.
Unusual DNA methylation in the C11orf52 gene in so... | 7,328 | zeroshot-train |
C11orf73 [SEP] chromosome | HIKESHI
HIKESHI is a protein important in lung and multicellular organismal development that, in humans, is encoded by the "HIKESHI" gene. HIKESHI is found on chromosome 11 in humans and chromosome 7 in mice. Similar sequences (orthologs) are found in most animal and fungal species. The mouse homolog, lethal gene on ch... | the EST Profile on UniGene, only 11 tissues were shown not to express C11orf73, most likely due to small sample sizes in the tissue.
Protein.
The human HIKESHI gene encodes for a protein called uncharacterized protein C11orf73. The homologous mouse L7rn6 gene encodes a protein called lethal gene on chromosome 7 Rinchik... | 7,329 | zeroshot-train |
C12orf40 [SEP] chromosome | C12orf40
C12orf40, also known as Chromosome 12 Open Reading Frame 40, HEL-206, and Epididymis Luminal Protein 206 is a protein that in humans is encoded by the "C12orf40" gene.
Gene.
Gene Human gene.
In humans, the gene for "C12orf40" is located on chromosome 12. There are 13 exons in the highest quality isoform, formi... | is predicted to be a soluble protein with no transmembrane segments. Its secondary and tertiary structures are not currently known.
Protein Interactions.
Experimental evidence shows that C12orf40 has a physical interaction with dynein light chain 2 (DYNLL2). This protein is part of a complex that regulates the function... | 7,330 | zeroshot-train |
C14orf80 [SEP] chromosome | C14orf80
Uncharacterized protein C14orf80 is a protein which in humans is encoded by the chromosome 14 open reading frame 80, C14orf80, gene.
Gene.
Gene Location.
C14orf80 is located on chromosome 14 (14q32.33) starting at 105,489,855bp and ending at 105,499,248bp. C14orf80 is 9,393 base pairs long and contains 11 exon... | of C14orf80 were found to range from primates to invertebrates. Below is a table that contains a variety of these orthologs.
Homology Evolution rate.
When compared to the slow-evolving cytochrome C gene and the fast-evolving fibrinogen gene, gene C14orf80 is also fast-evolving.
Protein.
Protein General properties.
Unch... | 7,331 | zeroshot-train |
C16orf42 [SEP] chromosome | C16orf42
C16orf42, or chromosome 16 open reading frame 42, is a hypothetical human protein found on chromosome 16. Its protein is 312 amino acids long. and its cDNA has 1214 base pairs
Function.
The function of C16orf42 is unknown. It is predicted to be a transmembrane protein, however the cellular or subcellular membr... | bacteria. C16orf42 is highly conserved in many of its orthologs, especially its mammalian orthologs, as high as 95% identity in rhesus monkeys. It also has fairly high conservation in its more distant homologs, 53% identity in corn for example. It has one potential human paralog, the protein EGFL6.
Ortholog Analysis:
E... | 7,332 | zeroshot-train |
C16orf84 [SEP] chromosome | C16orf84
CTU2 (formerly known as C16orf84) is a human gene located on chromosome 16. The mRNA encodes the longer isoform. The gene encodes a cytoplasmic protein that plays a probable role in tRNA modification. | - Integrating fragmented software applications into holistic solutions: focus on drug discovery Yuryev A, Expert Opinion on Drug Discovery, April 2011, 6(4):383-392(10)
- Analysis and construction of pathogenicity island regulatory pathways in Salmonella enterica serovar Typhi Ong SY, Ng FL, Badai SS, Yuryev A, Alam M,... | 7,333 | zeroshot-train |
C1orf123 [SEP] chromosome | C1orf123
C1orf123 (chromosome 1 open reading frame 23) is a gene in the human genome that encodes the protein of unknown function, C1orf123.
Gene.
"C1orf123" is a gene located in the human genome on the short arm of chromosome 1 at p32.2, between 53,679,771 base pairs and 53,686,289 base pairs. It is 6,519 bases long w... | gene expression data has shown that "C1orf123" is expressed in varying amounts within the human body. It is most highly expressed in nerve and pituitary glands and not expressed in other body sites such as ear, esophagus, larynx, and tonsil. When health states were compared for the expression of "C1orf123" it was found... | 7,334 | zeroshot-train |
C1orf131 [SEP] chromosome | C1orf131
Uncharacterized protein C1orf131 is a protein that in humans is encoded by the gene "C1orf131". The first ortholog of this protein was discovered in humans. Subsequently, through the use of algorithms and bioinformatics, homologs of C1orf131 have been discovered in numerous species, and as a result, the name o... | 193 other genes. Notably, the gene upstream of "C1orf131" is "GNPAT", and the gene downstream of "C1orf131" is "TRIM67". When this gene is transcribed in humans, "C1orf131" most often forms an mRNA of 1458 base pairs long which is composed of seven exons. There are at least nine others alternative splice forms in human... | 7,335 | zeroshot-train |
C1orf74 [SEP] chromosome | C1orf74
UPF0739 protein C1orf74 is a protein that in humans is encoded by the C1orf74 gene.
Gene.
The gene C1orf74 is a protein-encoding gene on chromosome 1 in humans. It is also known as URLC4 in humans. The locus of this gene is 1q32.2. C1orf74 is 2229 base pairs long. The gene contains two exons.
C1orf74 is downstr... | the nervous system, mammary and salivary glands, skin, and most internal organs.
Function.
One suggestion of C1orf74's function in humans comes from data that has been published only in NCBI from a paper that will come out later this year by Daigo and Nakamura. The authors found that C1orf74 is up-regulated in lung can... | 7,336 | zeroshot-train |
C2orf27 [SEP] chromosome | C2orf27
Uncharacterized protein C2orf27 is a protein that in humans is encoded by the C2orf27A gene. Although its function is not clearly understood, through the use of bioinformatic analysis more information is being brought to light.
Gene.
The mRNA is 1,222bp in length and is located at 2q21.2 with a total of five ex... | - Integrating fragmented software applications into holistic solutions: focus on drug discovery Yuryev A, Expert Opinion on Drug Discovery, April 2011, 6(4):383-392(10)
- Analysis and construction of pathogenicity island regulatory pathways in Salmonella enterica serovar Typhi Ong SY, Ng FL, Badai SS, Yuryev A, Alam M,... | 7,337 | zeroshot-train |
C5orf3 [SEP] chromosome | FAM114A2
FAM114A2 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.
Protein.
The FAM114A2 protein is 505 amino acids long with a molecu... | - Integrating fragmented software applications into holistic solutions: focus on drug discovery Yuryev A, Expert Opinion on Drug Discovery, April 2011, 6(4):383-392(10)
- Analysis and construction of pathogenicity island regulatory pathways in Salmonella enterica serovar Typhi Ong SY, Ng FL, Badai SS, Yuryev A, Alam M,... | 7,338 | zeroshot-train |
C5orf34 [SEP] chromosome | C5orf34
C5orf34 (chromosome 5 open reading frame 34) is a protein that in humans is encoded by the "C5orf34" gene (5p12).
C5orf34 is conserved in mammals, birds and reptiles with the most distant ancestor being the Burmese python, "Python bivittatus". The C5orf34 protein contains two mammalian conserved domains: DUF 45... | orthologs from the clade Aves.
Gene.
"C5orf34" is located on the negative DNA strand of the short arm of chromosome 6 at locus 12. The gene is 28,744 base pairs long and spans from base pair 43,486,701 to base pair 43,515,445. The gene produces a single transcript of 2,540 base pairs long and encodes for 638 amino acid... | 7,339 | zeroshot-train |
C6orf222 [SEP] chromosome | C6orf222
C6orf222 is a protein that in humans is encoded by the "C6orf222" gene (6p21.31). C6orf222 is conserved in mammals, birds and reptiles with the most distant ortholog being the green sea turtle,"Chelonia mydas". The C6orf222 protein contains one mammalian conserved domain: DUF3293. The protein is also predicted... | localization sequence (NLS) found between residues 142-151.
Protein Protein Interactions.
Although the bioinformatics programs MINT, STRING and Gene Cards did not reveal any protein interactions with C6orf222. A predicted BH3 domain in the C6orf222 protein was found to interact with both Bcl-2 and Bcl-xL, implicating C... | 7,340 | zeroshot-train |
C6orf58 [SEP] chromosome | C6orf58
C6orf58 is a humangene located at locus 6q22.33 of chromosome 6 and encodes for UPF0762, a protein which is subsequently secreted after cleavage of a signal peptide. DUF781, which is the singular identifiable domain in UPF0762, is tied to liver development in an orthologous protein in zebrafish. The function of... | were primarily detected in the larynx and trachea. Transcripts were only detected during the adult stage of development. Experimental microarray data, however, reveals additional regions of C6orf58 expression, namely in the salivary gland, thyroid, and small intestine. Arsenic may also regulate expression as it increas... | 7,341 | zeroshot-train |
C7orf25 protein UPF0415 [SEP] chromosome | C7orf25
C7orf25 protein UPF0415 (UPF0415) is a protein encoded on chromosome 7, in open reading frame 25 (C7orf25) and are located at domain of unknown function 1308. C7orf25 is located at the minus strand and encodes 12 proteins, one of them being UPF0415. This protein is believed to be active in the proteosome pathwa... | UPF0415 protein C7orf25 has one paralog which is FLJ18411. UPF0415 is also highly conserved in vertebrates. The following table shows a small selection of orthologs found using BLAST and BLAT and their identity to C7orf25 protein UPF0415.
Predicted protein features.
Predicted protein features Post Translational Modific... | 7,342 | zeroshot-train |
C7orf43 [SEP] chromosome | C7orf43
C7orf43 (Chromosome 7 Open reading frame 43) is a protein that in human is encoded by the gene "C7orf43". C7orf43 has no other human alias, but in mice can be found as BC037034.
Gene Locus.
In humans, "C7orf43" is located in the long arm of human chromosome 7 (7q22.1), and is on the negative (antisense) strand.... | in the human protein. This vacuolar targeting motif is shown to be conserved throughout mammals, reptiles, birds, amphibians, and bony fishes.
Protein Evolutionary history.
The C7orf43 protein has no paralogs in humans. However, C7orf43 orthologs can be found to be highly conserved in mammals, reptiles, and several spe... | 7,343 | zeroshot-train |
C9orf64 [SEP] chromosome | C9orf64
C9orf64 (Chromosome 9 open reading frame 64) is a gene located on chromosome 9, that in humans encodes the protein queuosine salvage protein. The function and biological process of the queuosine salvage protein is not well understood by the scientific community, but some evidence from orthologs indicates it may... | nervous system (brain, cortex, cerebellum, spinal cord, tibial nerve).
- TMEM179-is located on chromosome 14, and or 90. It is predicted to localize in the mitochondria membrane
- C9orf64 - this encodes the queosine salvage protein (the function of which is not well understood). Expression of this gene is highest in th... | 7,344 | zeroshot-train |
CBR1 [SEP] chromosome | doxorubicinol.
Structure.
Structure Gene.
Human CBR1 gene maps to chromosome 21 at q22.13, and includes 8 exons.
Structure Protein.
The enzyme consists of 277 amino acid residues and is widely distributed in human tissues such as liver, epidermis, stomach, small intestine, kidney, neuronal cells, and smooth muscle fibe... | membranes against lipid peroxidation, indicating that CBR1 may play an important role as an oxidation–reduction catalyst in biological processes.
Clinical significance.
CBR1 has been reported to relate to tumor progression. Suppression of CBR1 expression was associated with poor prognosis in uterine endometrial cancer ... | 7,345 | zeroshot-train |
CCDC82 [SEP] chromosome | CCDC82
Coiled-Coil Domain Containing protein 82 (CCDC82) is a protein that in humans, is encoded for by the gene of the same name, CCDC82. The CCDC82 gene is expressed in nearly all of human tissues at somewhat low rates. As of today, there are no patents involving CCDC82 and the function remains unknown.
Gene.
CCDC82 ... | significance.
CCDC82 is a circulat-responsive gene. Circulat is a product designed to restore systemic vascular health. It is a plant based product and taken by patients who suffer from diabetes or circulatory problems.
Clinical significance Possible function.
Based on the information that CCDC82 is affected by the Cir... | 7,346 | zeroshot-train |
CCDC90B [SEP] chromosome | CCDC90B
Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the "CCDC90B" gene.
Gene.
CCDC90B is located on chromosome 11 in humans. It is neighbored by:
- PCF11, a mammalian pre-mRNA cleavage complex 2 protein
- ANKRD42, ankyrin repeat protein involved with calcium ion bonding
- BC070093
... | Coiled-coil domain-containing protein 135
Coiled-coil domain-containing protein 135, also known as CCDC135, is a protein that in humans is encoded by the "CCDC135" gene.
Gene.
CCDC90B is located on chromosome 16 in humans. It is neighbored by:
- GPR97, G protein-coupled receptor 97.
- GPR56, encodes a member of the G p... | 7,347 | zeroshot-train |
CCL20 [SEP] chromosome | can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10. CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lu... | CCL20
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and functio... | 7,348 | zeroshot-train |
CCR5 [SEP] chromosome | CCR5
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.
In humans, the "CCR5" gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3. Certai... | C-C motif chemokine ligand 3 like 3
C-C motif chemokine ligand 3 like 3 is a protein that in humans is encoded by the CCL3L3 gene.
Function.
This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunore... | 7,349 | zeroshot-train |
CD24 [SEP] chromosome | a wide range of downstream signaling networks and is crucial for neural development. Cross-linking of CD24 on the surface of neutrophils induces apoptosis, and this appears to be defective in sepsis. CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity o... | CD24
Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the "CD24" gene. CD24 is a cell adhesion molecule.
Function.
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It ... | 7,350 | zeroshot-train |
CD93 [SEP] chromosome | series of epidermal growth factor like domains, a highly glycosylated mucin-like domain, a unique transmembrane domain and a short cytoplasmic tail. Due to their strong homology and their close proximity on chromosome 20, CD93 has been suggested to have arisen from the thrombomodulin gene through a duplication event.
E... | CD93
CD93 (Cluster of Differentiation 93) is a protein that in humans is encoded by the "CD93" gene. CD93 is a C-type lectin transmembrane receptor which plays a role not only in cell–cell adhesion processes but also in host defense.
Family.
CD93 belongs to the Group XIV C-Type lectin family, a group containing three o... | 7,351 | zeroshot-train |
CD99 [SEP] chromosome | CD99
CD99 antigen (Cluster of differentiation 99), also known as MIC2 or single-chain type-1 glycoprotein, is a heavily O-glycosylated transmembrane protein that is encoded by the "CD99" gene in humans. The protein has a mass of 32 kD. Unusually for a gene present on the X chromosome, the CD99 gene does not undergo X i... | result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11.
EWS/FLI functions as the master regulator. Other translocations are at t(21;22) and t(7;22). Ewing's sarcoma cells are positive for CD99 and MIC2, and negative for CD45.
Diagnosis.
The d... | 7,352 | zeroshot-train |
CDKL5 [SEP] chromosome | treating nonsense mutations in Duchenne muscular dystrophy. Finally a CDKL5 protein replacement therapy is in development.
Location.
The CDKL5 gene is located on the short (p) arm of the X chromosome at position 22. More precisely, the CDKL5 gene is located from base pair 18,443,724 to base pair 18,671,748 on the X chr... | CDKL5 UK
CDKL5UK is a UK-based charity that has been set up to raise awareness and funds for the global CDKL5 research effort.
About CDKL5 UK.
About CDKL5 UK Mission.
Money raised for CDKL5 UK will be put towards key aims which are to promote relief, care and services to promote health, for persons suffering from and a... | 7,353 | zeroshot-train |
CHEK2 [SEP] chromosome | CHEK2
CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers.
Gene location.
The CHEK2 gene is locat... | to deputy director in 2007. In May 2010, he was appointed director, succeeding Allan Bradley.
Stratton's research interests are in the area of genetics of cancer. In 1994 he assembled a research group that localised BRCA2, a major breast cancer susceptibility gene that repairs chromosomal damage, to chromosome 13. The ... | 7,354 | zeroshot-train |
CORO6 [SEP] chromosome | CORO6
Coronin-6 also known as coronin-like protein E (Clipin-E) is a protein that in humans is encoded by the CORO6 gene.
Coronin-6 is belongs to coronin family which is an actin binding protein. Human CORO6 gene is located on chromosome 17 on the cytogenetic band 17 p11.2. Gene CORO6 is well conserved across domain of... | CORO1A,
CORO1B,
CORO1C,
CORO2A,
CORO2B,
CORO7
The table compared "Homo sapiens" protein CORO6 to its paralogs
By comparing its paralogs we found that CORO1A and CORO1B are most related to CORO6.
Homology Orthologs.
CORO6 is highly conserved throughout the organisms from vertebrate to fungus, the organisms listed in the... | 7,355 | zeroshot-train |
COX5A [SEP] chromosome | COX5A
Cytochrome "c" oxidase subunit 5a is a protein that in humans is encoded by the COX5A gene. Cytochrome "c" oxidase 5A is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain.
Structure.
The COX5A gene, located on the q arm of chromo... | The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex.
Summary reaction:
Clinical significance.
COX5A (this gene) and COX5B are involved in the regulation of cancer cell metabolism by Bcl-2. COX5A interacts specifically with Bcl-2, but not with ... | 7,356 | zeroshot-train |
CUL4B [SEP] chromosome | CUL4B
Cullin-4B is a protein that in humans is encoded by the "CUL4B" gene which is located on the X chromosome. CUL4B has high sequence similarity with CUL4A, with which it shares certain E3 ubiquitin ligase functions. CUL4B is largely expressed in the nucleus and regulates several key functions including: cell cycle ... | cancers. Viruses such as HIV can also co-opt CUL4B-based complexes to promote viral pathogenesis. CUL4B complexes containing Cereblon are also targeted by the teratogenic drug thalidomide.
Structure.
Human CUL4B is 913 amino acids long and shares a high degree of sequence identity (84%) with CUL4A with the exception of... | 7,357 | zeroshot-train |
CXCL13 [SEP] chromosome | CXCR5. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. and is expressed highly in the liver, spleen, lymph nodes, and gut of humans. The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines.
In T lymphocytes, CXCL13 expression is t... | In addition, CXCR4 can also be found on vascular endothelial cells and neuronal/nerve cells.
CXCR5.
The chemokine receptor CXCR5 is expressed on B cells and CD4+ Tfh cells and is involved in lymphocyte homing and the development of normal lymphoid tissue. Its principal ligand is CXCL13 (or BLC).
CXCR6.
CXCR6 was former... | 7,358 | zeroshot-train |
CYP2D6 [SEP] chromosome | function) will have an exaggerated response to the drug and stronger side-effects.
Genetic basis of variability.
The genetic basis for CYP2D6-mediated metabolic variability is the "CYP2D6" allele, located on chromosome 22. Subjects possessing certain allelic variants will show normal, decreased, or no CYP2D6 function, ... | - Integrating fragmented software applications into holistic solutions: focus on drug discovery Yuryev A, Expert Opinion on Drug Discovery, April 2011, 6(4):383-392(10)
- Analysis and construction of pathogenicity island regulatory pathways in Salmonella enterica serovar Typhi Ong SY, Ng FL, Badai SS, Yuryev A, Alam M,... | 7,359 | zeroshot-train |
Chitinase domain-containing protein 1 [SEP] chromosome | Chitinase domain-containing protein 1
Chitinase domain-containing protein 1 (CHID1) is a highly conserved protein of unknown function located on the short (p) arm of chromosome 11 near the telomere. The protein has 27 introns, which allows for many isoforms of this gene. It has several aliases, the most common of which... | of this family, CAZY GH_18, belong to the chitinase class II group which includes chitinase, chitodextrinase and the killer toxin of "Kluyveromyces lactis". The chitinases hydrolyse chitin oligosaccharides. Another chitinase II member is the novel gene Chitinase domain-containing protein 1. The family also includes var... | 7,360 | zeroshot-train |
DEFA6 [SEP] chromosome | bacteria.
Several alpha defensin genes, including "DEFA6", are clustered on chromosome 8.
External links.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Defensin-6 | DEFA6
Defensin, alpha 6 (DEFA6) also known as human alpha defensin 6 (HD6) is a human protein that is encoded by the "DEFA6" gene. "DEFA6" is expressed in the Paneth cells of the ileum.
Function.
The alpha defensins are a family of microbicidal and cytotoxic peptides that defend the host against bacteria and viruses. H... | 7,361 | zeroshot-train |
DEPTOR [SEP] chromosome | DEPTOR
DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by the "DEPTOR" gene.
Structure.
The gene "DEPTOR" can be found only in vertebrates. In human, "DEPTOR" gene locates at chromosome 8, 8q24.12 with protein size 409... | mTOR signaling pathway as an endogenous regulator. A direct interaction between DEPTOR and mTOR has been shown. Overexpression of DEPTOR downregulates the activity of mTORC1 and mTORC2 "in vitro". mTORC1 and mTORC2 can both inhibit DEPTOR through phosphorylation.
Metabolism.
DEPTOR cell-autonomously regulates adipogene... | 7,362 | zeroshot-train |
DHRS7B [SEP] chromosome | DHRS7B
Dehydrogenase/reductase (SDR family) member 7B is an enzyme encoded by the DHRS7B gene in humans, found on chromosome 17p11.2. DHRS7B encodes a protein that is predicted to function in steroid hormone regulation. A deletion in the chromosomal region 17p11.2 has been associated with Smith-Magenis Syndrome, a gene... | .
Conservation of the DHRS7B protein sequence has been observed highly in mammals; moderately in reptiles, birds, fish and amphibians; minimally in invertebrates, insects, and fungi.
Homology Paralogs.
Paralogs of DHRS7B are all in the SDR superfamily and conservation of the SDR functional motifs was identified in a mu... | 7,363 | zeroshot-train |
DLC1 [SEP] chromosome | "DLC1" gene is located on the short arm of chromosome 8 (8p21.3-22), within a region that frequently undergoes loss of heterozygosity by either genomic deletion or epigenetic silencing mechanisms in several types of solid cancers. The gene contains 14 exons and produces an mRNA transcript that is 6.3 kb in length; the ... | an increase in the expression of DLC1, which in turn results in growth inhibition, decreased cell motility, and increased caspase-3-mediated apoptosis.
Lung cancer cells also increase DLC1 expression in response to peroxisome proliferator-activated receptor γ (PPARγ) activators. PPARγ is a steroid hormone receptor whic... | 7,364 | zeroshot-train |
DMT1 [SEP] chromosome | for direct absorption of metals into the brain. DMT1 expression in the brain may increase with age, increasing susceptibility to metal induced pathologies. DMT1 expression is found to be increased in the substantia nigra of Parkinson's patients and in the ventral mesencephalon of animal models intoxicated with 1-methyl... | Natural resistance-associated macrophage protein 2
Natural resistance-associated macrophage protein 2 (NRAMP 2), also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the "SLC11A2" (solute carrier family 11, member 2) gene. DMT1 represents ... | 7,365 | zeroshot-train |
Diablo homolog [SEP] chromosome | Diablo homolog
Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the "DIABLO" (direct IAP binding protein with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), ... | by ZZ Top from "Tejas" (1976)
- "El Diablo", a song by Frankie Laine (1959)
- "El Diablo", a song by Grace Slick from "Dreams" (1980)
Other uses.
- Diablo homolog, a gene
- Diablo sandwich, a fast-food entree
- Diablo Data Systems, a division of Xerox
- Diablo 630, a daisy wheel printer
See also.
- Diabolo (disambiguat... | 7,366 | zeroshot-train |
Dystroglycan [SEP] chromosome | Dystroglycan
Dystroglycan is a protein that in humans is encoded by the "DAG1" gene.
Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in "Homo sapiens" on chromosome 3. There are two exons that are separated by a large intron. The spliced exons code for a protein p... | . α-dystroglycan was shown to interact with pikachurin through immunoprecipitation.
Pikachurin-dystroglycan interaction.
Dystroglycan ligand with other proteins is essential. Glycosylation of dystroglycan is necessary for its ligand binding activity. Mutations in glycosyltransferase enzymes cause abnormal glycosylation... | 7,367 | zeroshot-train |
E-selectin [SEP] chromosome | selectin locus on chromosome 1.
Different from P-selectin, which is stored in vesicles called Weibel-Palade bodies, E-selectin is not stored in the cell and has to be transcribed, translated, and transported to the cell surface. The production of E-selectin is stimulated by the expression of P-selectin which in turn, i... | 133,189,767 to 133,192,979. Within this region, there is 1 intron and 2 exons.
Gene Gene neighborhood.
LOC101928193 is flanked by GBGT1 and 0BP2B on chromosome 9. GBGT1 encodes a member of the ABO gene family and also plays a role in synthesizing glycolipids that are involved in tropism and binding pathogens. 0BP2B is ... | 7,368 | zeroshot-train |
EP300 [SEP] chromosome | be critical for normal development before and after birth.
The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein.
EP300 is closely related to another gene, CREB binding protein, which ... | - Integrating fragmented software applications into holistic solutions: focus on drug discovery Yuryev A, Expert Opinion on Drug Discovery, April 2011, 6(4):383-392(10)
- Analysis and construction of pathogenicity island regulatory pathways in Salmonella enterica serovar Typhi Ong SY, Ng FL, Badai SS, Yuryev A, Alam M,... | 7,369 | zeroshot-train |
ERBB3 [SEP] chromosome | located on the long arm of chromosome 12 (12q13). It is encoded by 23,651 base pairs and translates into 1342 amino acids.
During human development, "ERBB3" is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium. "ERBB3" is expressed in normal adult human gastrointestinal tract, rep... | ERBB3
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.
ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is k... | 7,370 | zeroshot-train |
ETHE1 [SEP] chromosome | ETHE1
Protein ETHE1, mitochondrial, also known as "ethylmalonic encephalopathy 1 protein" and "per sulfide dioxygenase", is a protein that in humans is encoded by the "ETHE1" gene located on chromosome 19.
Structure.
The human ETHE1 gene consists of 7 exons and encodes for a protein that is approximately 27 kDa in size... | sulfur dioxygenase. Sulfur deoxygenates are proteins that function in sulfur metabolism. The ETHE1 protein is thought to catalyze the following reaction:
and requires iron and possibly glutathione as cofactors. The physiological substrate of ETHE1 is thought to be glutathione persulfide, an intermediate metabolite invo... | 7,371 | zeroshot-train |
EVI5L [SEP] chromosome | . It consists of 19 exons that encode for an 805 amino acid protein.
Gene Locus.
EVI5L is located on the short arm (p) of chromosome 19 in region 1, band 3, and sub-band 2 (19p13.2) starting at 7,830,275 base pairs and ending at 7,864,976 base pairs. It is encoded for on the plus strand. It is located near the CLEC4M (... | EVI5L
EVI5L (Ecotropic Viral Integration Site 5-Like) is a protein that in humans is encoded by the EVI5L gene. EVI5L is a member of the Ras superfamily of monomeric guanine nucleotide-binding (G) proteins, and functions as a GTPase-activating protein (GAP) with a broad specificity. Measurement of in vitro Rab-GAP acti... | 7,372 | zeroshot-train |
Endothelial NOS [SEP] chromosome | Endothelial NOS
Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the "NOS3" gene located in the 7q35-7q36 region of chromosome 7. This enzyme is one of three isoforms that synthesize nitric oxide (NO), a small gaseous and lipophil... | byproduct. NO production by eNOS is dependent on calcium-calmodulin and other cofactors.
Nitric oxide synthases (NOSs) synthesize the metastable free radical nitric oxide (NO). Three isoforms are known for the NOS enzyme: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS) - each with separate functions. The neur... | 7,373 | zeroshot-train |
FAM214A [SEP] chromosome | segregation during meiosis.
Gene.
Gene Overview.
The "FAM214A" gene is located on the negative DNA strand (see Sense (molecular biology)) of chromosome 15 between position 52,873,514 and 53,002,014; thus making the gene 97,303 base pairs (bp) long. "FAM214A" has been previously labeled with two other aliases, known as ... | able to predict approximately 10 percent of the protein's structure with 95 percent significance. The diagram for this is shown to the left.
Conservation.
Conservation Paralog.
A single paralogous gene has been found on chromosome 9 in Homo sapiens and is named "FAM214B" (family with sequence similarity, B). FAM214B, a... | 7,374 | zeroshot-train |
FAM40A [SEP] chromosome | FAM40A
Protein FAM40A is a protein that is located on chromosome 1 in humans and is encoded by the "FAM40A" gene.
Characteristics and secondary structure.
FAM40A has an isoelectric point of 5.92 and a molecular weight of 95,575 daltons. It is predicted to have three transmembrane domains, making it a transmembrane prot... | -six alpha helices and two beta sheets. The 5' untranslated region of FAM40A is predicted to contain one stem-loop and the 3' untranslated region is predicted to contain eight stem-loop structures. Two miRNAs are predicted to bind to two of the stem-loop structures present in the 3' UTR region.
Homology.
FAM40A has no ... | 7,375 | zeroshot-train |
FAM46C [SEP] chromosome | FAM46C
Protein FAM46C also known as family with sequence similarity 46, member C is a protein that, in humans, is encoded by the "FAM46C" gene at locus 1p12 spanning base pairs from 118,148,556 to 118,171,011.
Summary.
FAM46C is a protein of unknown function consisting of 391 amino acid residues that are translated fro... | one domain of unknown function, DUF1693, and as such has been placed in the DUF1693 protein family. This protein family has been established as a part of the Nucleotidyltransferase superfamily and contains 4 nematode prion-like proteins. FAM46C was placed into group XXV of the nucleotidyltransferase superfamily along w... | 7,376 | zeroshot-train |
FAM83A [SEP] chromosome | FAM83A
Protein FAM83A (family member with sequence similarity 83) also known as tumor antigen BJ-TSA-9 is a protein that in humans is encoded by the FAM83A gene.
This protein is predicted to contain one domain of unknown function 1669 (DUF1669), which places this protein into the PLDc_SuperFamily. It has been linked to... | approximately 4,000 base pairs upstream as predicted by the tool ElDorado by Genomatix. Deletions in this part of the chromosome, including the FAM83A gene, often result in Langer-Giedion syndrome.
mRNA.
The FAM83A mRNA has 10 different splice forms, with transcript variant 1 being the subject of this article. This mRN... | 7,377 | zeroshot-train |
FAM83H [SEP] chromosome | FAM83H
FAM83H is a gene in humans that encodes a protein known as FAM83H (uncharacterized protein FAM83H). FAM83H is targeted for the nucleus and it predicted to play a role in the structural development and calcification of tooth enamel.
Gene.
Gene Location.
FAM83H is located on the long arm of chromosome 8 (8q24.3), ... | exons.
Gene Expression.
FAM83H is ubiquitously expressed throughout the human body at relatively low levels.
Gene Transcript Variants.
In humans, there is only one known major product of the FAM83H gene.
Homology.
Homology Paralogs.
There are no paralogs of FAM83H
Homology Orthologs.
Below is a table of a variety of or... | 7,378 | zeroshot-train |
FANCA [SEP] chromosome | anaemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. The FANCA gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms.
Function Gene and protein.
I... | FANCA
Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the "FANCA" gene. It belongs to the Fanconi anaemia complementation group (FANC) family of genes of which 12 complementation groups are currently recognized and is hypothesised to operate as a p... | 7,379 | zeroshot-train |
FMR1 [SEP] chromosome | FMR1" gene is located on the X chromosome and contains a repeated CGG trinucleotide. In most people, the CGG segment is repeated approximately 5-44 times. Higher numbers of repeats of the CGG segment are associated with impaired cognitive and reproductive function. If a person has 45-54 repeats this is considered the “... | FMR1-AS1 gene
In molecular biology, FMR1 antisense RNA 1 (FMR1-AS1), also known as ASFMR1 or FMR4, is a long non-coding RNA. The FMR1-AS1 gene overlaps, and is antisense to, the CGG repeat region of the FMR1 gene. Its expression is upregulated in fragile X syndrome premutation carriers, and silenced in patients with fr... | 7,380 | zeroshot-train |
FOXE3 [SEP] chromosome | FOXE3
Forkhead box protein E3 (FOXE3) also known as forkhead-related transcription factor 8 (FREAC-8) is a protein that in humans is encoded by the "FOXE3" gene located on the short arm of chromosome 1.
Function.
FOXE3 is a forkhead-box transcription factor which is involved in the proper formation of the ocular lens a... | formation of the lens placode, a precursor to the lens of the eye, and the lens itself. Foxe3 controls multiple processes during development of the lens including, the expression of Cryaα which controls the solubility of the crystalline protein complex in the developing lens. Reduced solubility can lead to potential ca... | 7,381 | zeroshot-train |
FZD9 [SEP] chromosome | FZD9
Frizzled-9 is a protein that in humans is encoded by the "FZD9" gene. FZD9 has also been designated as CD349 (cluster of differentiation 349).
Function.
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Wi... | . This protein has been found to localize to the cytosol and mitochondria of cells. Though its exact biological function has yet to be elucidated, the centromeric location of DNAJC30 on the chromosome has led Merla et al. to postulate that it may contribute to functions such as subtle defects in cognition, transient hy... | 7,382 | zeroshot-train |
GCSH [SEP] chromosome | the one-carbon fragment from the intermediate lipoyl residue to tetrahydrofolate, while the L-protein, a lipoamide dehydrogenase, catalyzes the oxidation of the dihydrolipoyl residue of H-protein and reduction of NAD.
Structure.
Structure Gene.
Human GCSH gene has 5 exons spanning 13.5kb and resides on chromosome 16 at... | GCSH
Glycine cleavage system H protein, mitochondrial (abbreviated as GCSH) is a protein that in humans is encoded by the "GCSH" gene. Degradation of glycine is brought about by the glycine cleavage system (GCS), which is composed of 4 protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase... | 7,383 | zeroshot-train |
GJA1 [SEP] chromosome | GJA1
Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the "GJA1" gene on chromosome 6. As a connexin, GJA1 is a component of gap junctions, which allow for gap junction intercellular communication (GJIC) between cells to regulate cell death, proliferation,... | Craniometaphyseal dysplasia
Craniometaphyseal dysplasia is a rare skeletal disorder that results from a mutation in the ANKH or GJA1 genes. The condition is characterized abnormal facial features, impairment of cranial nerves, and malformation of the long bones in the limbs.
Signs and symptoms.
Signs and symptoms inclu... | 7,384 | zeroshot-train |
GLRX5 [SEP] chromosome | GLRX5
Glutaredoxin 5, also known as GLRX5, is a protein which in humans is encoded by the "GLRX5" gene located on chromosome 14. This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron- sulfur clusters, which are required for normal iron homeostasis. Mutati... | highly expressed in erythroid cells. Crystal structure of the GLRX5 protein reveals that the protein likely exists as a tetramer with two Fe-S clusters buried in the interior.
Function.
GLRX5 is a mitochondrial protein is conserved evolutionarily and plays a role in the formation of iron-sulfur clusters, which function... | 7,385 | zeroshot-train |
GPR113 [SEP] chromosome | GPR113
GPR113 is a gene that encodes the Probable G-protein coupled receptor 113 protein.
Gene.
The "Homo sapiens" GPR113 gene is located on chromosome 2 (2p23.3). This gene spans the length of a 38.65kb region from base 26531041 to 26569685 on the negative strand. The GPR113 gene has two neighbors on either side on th... | .
The protein product of GPR113 gene is a G-protein coupled receptor. The protein has three transcript variants in humans. Of these three, GPR113 Variant 1 has the longest amino acid sequence, and has the highest identity to orthologs. This leads to the conclusion that GPR113 Variant 1 is the homo sapiens descendant of... | 7,386 | zeroshot-train |
GRB7 [SEP] chromosome | by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.
Clinical significance.
GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine k... | GRB7
Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the "GRB7" gene.
Function.
The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a ... | 7,387 | zeroshot-train |
GTPBP3 [SEP] chromosome | GTPBP3
tRNA modification GTPase GTPBP3, mitochondrial is an enzyme that in human is encoded by the "GTPBP3" gene on chromosome 19.
The GTPBP3 gene encodes a GTP-binding protein that is evolutionarily conserved from bacteria to mammals and which is localized to the mitochondrion and functions in tRNA modification. At le... | consistent with its modification of the severity of phenotypes in 12S rRNA A1555G mutation..
Clinical Significance.
Mutations in GTPBP3 are known to cause hypertrophic cardiomyopathy and mitochondrial defects. Individuals with homozygous or compound heterozygous mutations in GTPBP3 present with combined deficiency of r... | 7,388 | zeroshot-train |
Galectin-3 [SEP] chromosome | cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis.
Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21–q22. Galectin-3 is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space.
Function.
Galectin-3 has ... | LGALS3BP
Galectin-3-binding protein is a protein that in humans is encoded by the "LGALS3BP" gene.
Function.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Using fluorescence in–situ hybridization, the full length 90K cDNA has been locali... | 7,389 | zeroshot-train |
Gamma-glutamyl carboxylase [SEP] chromosome | Gamma-glutamyl carboxylase
Gamma-glutamyl carboxylase is an enzyme that in humans is encoded by the "GGCX" gene, located on chromosome 2 at 2p12.
Function.
Gamma-glutamyl carboxylase is an enzyme that catalyzes the posttranslational modification of vitamin K-dependent proteins. Many of these vitamin K-dependent protein... | related vitamin K2-dependent protein osteocalcin. In bone, its production is increased by vitamin D.
Genetics.
The "MGP" was linked to the short arm of chromosome 12 in 1990. Its mRNA sequence length is 585 bases long in humans.
Physiology.
MGP and osteocalcin are both calcium-binding proteins that may participate in t... | 7,390 | zeroshot-train |
Glucagon-like peptide 2 receptor [SEP] chromosome | Glucagon-like peptide-2 receptor
Glucagon-like peptide-2 receptor (GLP-2R) is a protein that in human is encoded by the "GLP2R" gene located on chromosome 17.
Function.
The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor (GLP1 receptor). Glucagon-like pe... | Glucagon-like peptide-1 receptor
The glucagon-like peptide-1 receptor (GLP1R) is a receptor protein found on beta cells of the pancreas. It is involved in the control of blood sugar level by enhancing insulin secretion. In humans it is synthesised by the gene "GLP1R", which is present on chromosome 6. It is a member of... | 7,391 | zeroshot-train |
Glucose-6-phosphate isomerase [SEP] chromosome | Glucose-6-phosphate isomerase
Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is an enzyme that in humans is encoded by the "GPI" gene on chromosome 19.
This gene encodes a member of the glucose phosphate isomerase prote... | hydroxypyruvate isomerase
- : 5-methylthioribose-1-phosphate isomerase
- : phosphoribosylanthranilate isomerase
- : L-fucose isomerase
- : galactose-6-phosphate isomerase
- : 6-phospho-3-hexuloisomerase
- : D-sedoheptulose 7-phosphate isomerase
EC 5.3: Intramolecular Oxidoreductases EC 5.3.2: Interconverting Keto- and ... | 7,392 | zeroshot-train |
Glutaryl-CoA dehydrogenase [SEP] chromosome | Glutaryl-CoA dehydrogenase
Glutaryl-CoA dehydrogenase (GCDH) is an enzyme encoded by the GCDH gene on chromosome 19. The protein belongs to the acyl-CoA dehydrogenase family (ACD). It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the degradative pathway of L-lysine, L-hyd... | Glutaryl-CoA dehydrogenase (non-decarboxylating)
Glutaryl-CoA dehydrogenase (non-decarboxylating) (, "GDHDes", "nondecarboxylating glutaryl-coenzyme A dehydrogenase", "nondecarboxylating glutaconyl-coenzyme A-forming GDH") is an enzyme with systematic name "glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating)... | 7,393 | zeroshot-train |
HBB [SEP] chromosome | 11. Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria.
Gene locus.
HBB protein is produced by the gene "HBB" which is located in the multigene loc... | HBB
Beta globin (also referred to as HBB, β-globin, haemoglobin beta, hemoglobin beta, or preferably haemoglobin subunit beta) is a globin protein, which along with alpha globin (HBA), makes up the most common form of haemoglobin in adult humans, the HbA. It is 146 amino acids long and has a molecular weight of 15,867 ... | 7,394 | zeroshot-train |
HK2 [SEP] chromosome | HK2
Hexokinase 2 also known as HK2 is an enzyme which in humans is encoded by the "HK2" gene on chromosome 2. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It loca... | provided by RefSeq, Apr 2009]
Structure.
HK2 is one of four highly homologous hexokinase isoforms in mammalian cells.
Structure Gene.
The "HK2" gene spans approximately 50 kb and consists of 18 exons. There is also an "HK2" pseudogene integrated into a long interspersed nuclear repetitive DNA element located on the X c... | 7,395 | zeroshot-train |
HK3 [SEP] chromosome | HK3
Hexokinase 3 also known as HK3 is an enzyme which in humans is encoded by the "HK2" gene on chromosome 5. Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme... | regulate HK3, and the double regulation may better suit its anabolic functions. By phosphorylating glucose, HK3 effectively prevents glucose from leaving the cell and, thus, commits glucose to energy metabolism. Compared to HK1 and HK2, HK3 possesses a higher affinity for glucose and will bind the substrate even at phy... | 7,396 | zeroshot-train |
HLA-A [SEP] chromosome | arm of chromosome 6 and encodes the larger, α-chain, constituent of HLA-A. Variation of HLA-A α-chain is key to HLA function. This variation promotes genetic diversity in the population. Since each HLA has a different affinity for peptides of certain structures, greater variety of HLAs means greater variety of antigens... | , while HLA-A11 is associated with the disease in Koreans. Several genes within this region of class I HLA are believed to be responsible for DPB, by allowing increased susceptibility to the disease. The common genetic background and similarities in the HLA profile of affected Japanese and Korean individuals were consi... | 7,397 | zeroshot-train |
HLA-B [SEP] chromosome | are categorized together; for example, at least 28 very similar alleles are subtypes of HLA-B27. These subtypes are designated as HLA-B*2701 to HLA-B*2728.
The HLA-B gene is located on the short (p) arm of chromosome 6 at cytoband 21.3, from base pair 31,353,871 to 31,357,211
Related conditions.
Ankylosing spondylitis... | , while HLA-A11 is associated with the disease in Koreans. Several genes within this region of class I HLA are believed to be responsible for DPB, by allowing increased susceptibility to the disease. The common genetic background and similarities in the HLA profile of affected Japanese and Korean individuals were consi... | 7,398 | zeroshot-train |
HLA-C [SEP] chromosome | HLA-C
HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to ... | , an office in Cairo and a virtual office address in New York City. Since 2007, all of Hindawi's journals have been open access and published under a Creative Commons Attribution License (CC-BY). It is a founding member of the Open Access Scholarly Publishers Association, a participating publisher and supporter of the ... | 7,399 | zeroshot-train |
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