query stringlengths 17 395 | pos list | neg list | task stringclasses 1
value | instruction dict |
|---|---|---|---|---|
Does treatment with egg antigens of Schistosoma mansoni ameliorate experimental colitis in mice through a colonic T-cell-dependent mechanism? | [
"Helminth-derived molecules are being identified as a new therapeutic approach for immune-mediated diseases. We investigated the anti-inflammatory effect and the immunological mechanisms of Schistosoma mansoni soluble egg antigens (SmSEA) in a mouse model of chronic colitis. Colitis was induced in immunocompromised... | [
"The Gram-negative bacterium Helicobacter pylori is a constituent of the human gastric microbiota. Chronic infection with H. pylori causes gastritis and predisposes to gastric carcinoma but has also been inversely linked to various allergic and chronic inflammatory conditions. In particular, large meta-analyses hav... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is abnormal left ventricular contractile response to exercise in the absence of obstructive coronary artery disease associated with resting left ventricular long-axis dysfunction? | [
"The etiology of reduced left ventricular (LV) ejection fraction after exercise, without obstructive coronary artery disease or other established causes, is unclear. The aims of this study were to determine whether patients undergoing treadmill stress echocardiography with this abnormal LV contractile response to e... | [
"Diastolic dysfunction is important in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Sympathetic nervous hyperactivity may contribute to the development of diastolic dysfunction. The aim of this study was to determine the relationship between myocardial sympathetic innervation quant... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is sleep efficiency ( but not sleep duration ) of healthy school-age children associated with grades in math and languages? | [
"The objective of this study was to examine the associations between objective measures of sleep duration and sleep efficiency with the grades obtained by healthy typically developing children in math, language, science, and art while controlling for the potential confounding effects of socioeconomic status (SES), ... | [
"In an earlier series of studies, we documented the effects of feeding practices and postnatal maternal mood on the growth and development of 226 Barbadian children during the first few months of life. In this report, we extend our earlier studies by examining predictive relationships between infant size, feeding p... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are vitamin D levels and bone turnover markers related to non-alcoholic fatty liver disease in severely obese patients? | [
"Morbidly obese patients usually present vitamin D deficiency or secondary hyperparathyroidism. Low vitamin D levels have been recently related to non-alcoholic fatty liver disease (NAFLD). The aim of this study was to analyse the relationship between vitamin D, bone turnover markers and non-alcoholic fatty liver d... | [
"The adipocytokine adiponectin has been proposed to play important roles in the regulation of energy homeostasis, insulin sensitivity and shows anti-inflammatory properties. In this study we investigated the role of circulating adiponectin in different chronic liver diseases, its regulation by systemic anti-tumour ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are outcomes of abdominal wall reconstruction with acellular dermal matrix affected by wound contamination? | [
"The optimal type of mesh for complex abdominal wall reconstruction has not been elucidated. We hypothesized that AWRs using acellular dermal matrix (ADM) experience low rates of surgical site occurrence (SSO) and surgical site infection, despite increasing degrees of wound contamination. We retrospectively reviewe... | [
"Debriding deep thermal injury to face and neck can be particularly challenging with cold knife techniques. Timely healing, a precondition for minimal scarring, is dependant upon optimal wound bed preparation. A new water-jet surgical tool (Versajet) (Smith & Nephew, Hull, UK) has been designed for wound debridemen... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does airway pressure release ventilation reduce conducting airway micro-strain in lung injury? | [
"Improper mechanical ventilation can exacerbate acute lung damage, causing a secondary ventilator-induced lung injury (VILI). We hypothesized that VILI can be reduced by modifying specific components of the ventilation waveform (mechanical breath), and we studied the impact of airway pressure release ventilation (A... | [
"The importance of applying high-frequency oscillatory ventilation with a high lung volume strategy in infants is well established. Currently, a lack of reliable methods for assessing lung volume limits clinicians' ability to achieve the optimum volume range. To map the pressure-volume relationship of the lung duri... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do a simplified method of preventing implant hex drive from aspiration or accidental swallowing during stage two implant recovery? | [
"To prevent accidental ingestion of implant hex dive. Dental floss which is used to stabilize the hex drive is tied to the operator's finger ring to overcome sudden aspiration of fallen instrument. It showed excellent grip of the instrument during stage two uncover time and also saved operators time."
] | [
"The Safe guide is a central venous puncture needle that serves as both a pilot needle and as an introducer. A guide wire can be inserted into a vein through the side port at the hub of the 22-gauge Safe guides needle initially inserted as a pilot needle. However, guide wire insertion may fail due to kinking or loc... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is late onset spinal motor neuronopathy caused by mutation in CHCHD10? | [
"A study was undertaken to identify the responsible gene defect underlying late onset spinal motor neuronopathy (LOSMoN/SMAJ; Online Mendelian Inheritance in Man #615048), an autosomal dominant disease mapped to chromosome 22q11.2. The previous genetic linkage approach by microsatellite haplotyping was continued in... | [
"Familial hemophagocytic lymphohistiocytosis (FHL) is a rare and often fatal disorder characterized by defective cellular cytotoxicity and hyperinflammation, and the only cure known to date is hematopoietic stem cell transplantation. Mutations in RAB27A, LYST, and AP3B1 give rise to FHL associated with oculocutaneo... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does low perfusion index affect the difference in glucose level between capillary and venous blood? | [
"In emergency cases, finger stick testing is primarily used to check the blood glucose value of patients since it takes longer to obtain the venous value. In critical patients, under conditions that cause an increase in metabolic state and level of stress, there occurs considerable difference in glucose levels betw... | [
"Elevated potassium concentrations due to in vitro hemolysis can lead to errors in diagnoses and treatment. Recently, we observed that potassium elevation in capillary samples appeared higher than expected, based on hemolytic index (H-index). To investigate the relation between potassium increase and H-index for ca... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are multiple pathways responsible for anti-inflammatory and cardiovascular activities of Hordeum vulgare L? | [
"Hordeum vulgare L. (HV or barley) is used by traditional healers to treat various inflammatory and cardiovascular diseases, without the knowledge of pharmacologic rationale behind its actions. This study was designed to explore the potential scientific mechanism(s) that could explain the use of Hordeum vulgare in ... | [
"Previous reports suggest that Brazilian propolis has multiple biological functions and may help to restore adiponectin expression and insulin sensitivity. However, little is known about the molecular mechanisms by which these compounds inhibit the downregulation of adiponectin. The effect of various Brazilian prop... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does [ ITF increase the transcriptional activity of ITF promoter via the JAK-STAT3 signal transduction pathway ]? | [
"To investigate the eff ect of intestinal trefoil factor (ITF) on the transcriptional activity of ITF promoter and to explore the regulatory mechanism of Janus kinase/signal transducers and activators of transcription (JAK/STAT) on ITF promoter. The 5' flanking sequence of the ITF gene was cloned from human whole b... | [
"The role of cannabinoid receptor type 2 (Cnr2) in regulating immune function had been widely investigated, but the mechanism is not fully understood. Cnr2 activation down-regulates 5-lipoxygenase (Alox5) expression by suppressing the JNK/c-Jun activation."
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does clinical evaluation of pazopanib eye drop versus ranibizumab intravitreal injections in subjects with neovascular age-related macular degeneration? | [
"To evaluate pazopanib eye drops in subjects with active subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). Multicountry, randomized, parallel-group, double-masked, active and placebo-controlled, dose-ranging study of eye drops. A total of 510 subjects (93% white; 58% ... | [
"The purpose of this study is to report a case of diabetic macular edema that resolved after systemic bevacizumab. This is an observational case report of a patient with diabetic macular edema. After initiation of systemic bevacizumab for a central nervous system glioblastoma, the diabetic macular edema resolved."
... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does long-term treadmill exercise attenuate tau pathology in P301S tau transgenic mice? | [
"Recent epidemiological evidence suggests that modifying lifestyle by increasing physical activity could be a non-pharmacological approach to improving symptoms and slowing disease progression in Alzheimer's disease and other tauopathies. Previous studies have shown that exercise reduces tau hyperphosphorylation, h... | [
"The inhibition of the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is a main therapeutic approach for the treatment of Alzheimer's disease (AD). We previously reported an age-related increase of tau protein in the cerebrospinal fluid (CSF) of amyloid-β (Aβ) precursor protein (APP) transgenic mice. AP... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does alpha and beta EEG power reflect L-dopa acute administration in parkinsonian patients? | [
"To evaluate the effect of an acute L-dopa administration on eye-closed resting state electroencephalographic (EEG) activity of cognitively preserved Parkinsonian patients. We examined 24 right-handed patients diagnosed as uncomplicated probable Parkinson's disease (PD). Each patient underwent Unified Parkinson's D... | [
"In Parkinson's disease, sleep disturbance is a common occurrence. We evaluated sleep in 10 patients with Parkinson's disease (age, 57.5 ± 9.8 years; disease duration, 12.3 ± 2.7 years) before and after subthalamic nucleus deep brain stimulation using the Parkinson's disease sleep scale and polysomnography. Their t... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does subclinical left ventricular dysfunction by echocardiographic speckle-tracking strain analysis relate to outcome in sarcoidosis? | [
"Limited data exist on the risk of developing cardiac sarcoidosis (CS) and/or adverse events in sarcoidosis patients. Using LV global longitudinal strain (GLS), an emerging sensitive parameter of LV function, we evaluated the prevalence of subclinical cardiac dysfunction in sarcoidosis and investigated whether LVGL... | [
"Our aim was to investigate the associations between B-type natriuretic peptide (NT-proBNP), troponin T (TnT) and C-reactive protein (CRP) and changes in left ventricular function and size after acute coronary syndrome. In 119 patients admitted for non-ST-elevation acute coronary syndrome, echocardiography and bloo... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are guanine quadruplexes formed by specific regions of human transposable elements? | [
"Transposable elements form a significant proportion of eukaryotic genomes. Recently, Lexa et al. (Nucleic Acids Res 42:968-978, 2014) reported that plant long terminal repeat (LTR) retrotransposons often contain potential quadruplex sequences (PQSs) in their LTRs and experimentally confirmed their ability to adopt... | [
"Malaria parasites of the genus Plasmodium possess large hyper-variable families of antigen-encoding genes. These are often variantly-expressed and are major virulence factors for immune evasion and the maintenance of chronic infections. Recombination and diversification of these gene families occurs readily, and m... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is circulating soluble LR11 , a novel marker of smooth muscle cell proliferation , enhanced after coronary stenting in response to vascular injury? | [
"Restenosis after vascular intervention remains a major clinical problem. Circulating LR11 has been shown a novel marker of intimal smooth muscle cell (SMC) proliferation in human and animal studies. The present study was performed to clarify the clinical significance of circulating LR11 in patients with stable ang... | [
"Veins are still the best conduits available for arterial bypass surgery. When these arterialized vein grafts fail, it is often due to the development of intimal hyperplasia (IH). We investigated the feasibility and efficacy of the ex vivo pre-treatment of vein grafts with soluble carbon monoxide (CO) in the inhibi... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are de novo donor-specific HLA antibodies associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation? | [
"The development of human leukocyte antigen (HLA) antibody responses has been associated with worse clinical outcomes, such as bronchiolitis obliterans syndrome (BOS) and death, in lung transplant recipients (LTRs). However, the role of donor-specific HLA antibody (DSA) responses as a risk factor for poor outcomes ... | [
"Cellular engraftment after allogeneic hematopoietic progenitor cell transplantation (HPCT) can be affected by pre-HPCT antibodies against donor human leukocyte antigen (HLA; donor-specific antibodies [DSAs]), which are commonly acquired by either pregnancy or transfusion. Issues regarding high assay sensitivity an... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does a systematic review identify valid comorbidity indices derived from administrative health data? | [
"To conduct a systematic review of studies reporting on the development or validation of comorbidity indices using administrative health data and compare their ability to predict outcomes related to comorbidity (ie, construct validity). We conducted a comprehensive literature search of MEDLINE and EMBASE, until Sep... | [
"The clock drawing test (CDT) is a widely used cognitive screening tool that has been well accepted among clinicians and patients for its ease of use and short administration time. Although there is ample interest in the CDT as a screening instrument, there remains a range of CDT administration and scoring systems ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production? | [
"The consumption of an agrarian diet is associated with a reduced risk for many diseases associated with a 'Westernised' lifestyle. Studies suggest that diet affects the gut microbiota, which subsequently influences the metabolome, thereby connecting diet, microbiota and health. However, the degree to which diet in... | [
"Gut microbiota and the host exist in a mutualistic relationship, with the functional composition of the microbiota strongly affecting the health and well-being of the host. Thus, it is important to develop a synthetic approach to study the host transcriptome and the microbiome simultaneously. Early microbial colon... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is disruption of SOX6 associated with a rapid-onset dopa-responsive movement disorder , delayed development , and dysmorphic features? | [
"Sox6 is a transcription factor that is crucial for the differentiation and development of cortical interneurons and dopaminergic neurons of the substantia nigra pars compact. Loss-of-function mutations might thus result in complex paroxysmal diseases such as epilepsy syndromes or movement disorders. We present a 1... | [
"To investigate the clinical spectrum caused by mutations in PIGA at Xp22.2, which is involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) anchor, among patients with early-onset epileptic encephalopathies (EOEEs). Whole-exome sequencing was performed as a comprehensive genetic analysis for a coho... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does capsular closure affect development of heterotopic ossification after hip arthroscopy? | [
"The purpose of this study was to evaluate the role of capsular closure after hip arthroscopy in reduction of the incidence of heterotopic ossification (HO). One hundred (50 study group, 50 control group) consecutive hip arthroscopy procedures with radiographic follow-up of more than 9 weeks were included in the st... | [
"Autologous chondrocyte implantation is associated with a high rate of reoperation, mostly due to hypertrophy of the periosteal patch. European studies investigating the use of collagen membranes as a periosteal substitute report significant decreases in reoperation rates to less than 5%. This multicenter study inv... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do smoking and unstable hinge fractures cause delayed gap filling irrespective of early weight bearing after open wedge osteotomy? | [
"The purpose of this study was to examine the osteotomy gap filling rate with new bone after open wedge high tibial osteotomy (HTO) without bone graft and the effects of smoking, lateral hinge fracture, and early full weight bearing. A prospective series (N = 70) of open wedge HTOs with the TomoFix plate (DePuy Syn... | [
"Treatment of displaced proximal humerus fractures remains challenging. The introduction of locking plates has renewed interest in treating these fractures with joint-preserving techniques rather than hemiarthroplasty, but high complication rates are still reported. Avascular necrosis is not solely dependent on the... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is topical clobetasol in conjunction with topical tretinoin effective in preventing scar formation after superficial partial-thickness burn ulcers of the skin : A retrospective study? | [
"Deep erythema and inflammation after re-epithelialization of superficial wounds is a sign of scar formation. Corticosteroids may prevent scarring by suppression of inflammation and fibroblast activity. Tretinoin may increase the efficacy of corticosteroids in this setting. To evaluate the efficacy of corticosteroi... | [
"Recently, higher proliferative activity and collagen production in the peripheral parts of keloids have been reported. Therefore, we hypothesized that insufficient removal of active proliferating and collagen-producing fibroblasts at the scar margin might cause a high recurrence rate of hypertrophic scars and kelo... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does the rate of hypo-osmotic challenge influence regulatory volume decrease ( RVD ) and mechanical properties of articular chondrocytes? | [
"Osteoarthritis (OA) is associated with a gradual reduction in the interstitial osmotic pressure within articular cartilage. The aim of this study was to compare the effects of sudden and gradual hypo-osmotic challenge on chondrocyte morphology and biomechanics. Bovine articular chondrocytes were exposed to a reduc... | [
"Chronic elevation in intracellular Ca(2+) concentration participates in death of skeletal muscle from mdx mice, a model for Duchenne muscular dystrophy (DMD). Candidate pathways mediating this Ca(2+) overload involve store-operated channels (SOCs) and stretch-activated channels (SACs), which are modulated by the C... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does liver-specific deletion of augmenter of liver regeneration accelerate development of steatohepatitis and hepatocellular carcinoma in mice? | [
"Augmenter of liver regeneration (ALR, encoded by GFER) is a widely distributed pleiotropic protein originally identified as a hepatic growth factor. However, little is known about its roles in hepatic physiology and pathology. We created mice with liver-specific deletion of ALR to study its function. We developed ... | [
"The increasing prevalence of nonalcoholic steatohepatitis (NASH) is due to the epidemic of obesity and type 2 diabetes, both of which are associated with insulin resistance. To clarify the causal relationship between insulin resistance and the development of NASH, steatohepatitis was induced in obese diabetic Otsu... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveal proton pump inhibitor-reversible allergic inflammation? | [
"Esophageal eosinophilia can be proton pump inhibitor (PPI) resistant or responsive, representing 2 entities known as eosinophilic esophagitis (EoE) and PPI-responsive esophageal eosinophilia (PPI-REE), respectively. Although they present with similar clinical features, EoE is accepted to be an antigen-driven, TH2-... | [
"The key features of aspirin-exacerbated respiratory diseases (AERDs) include chronic, severe asthma and a high prevalence (60-80%) of chronic rhinosinusitis with nasal polyps, all of which are exacerbated by exposure to aspirin and other NSAIDs. Although the pathogenic mechanisms of AERD are not completely underst... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is a high normal thyroid-stimulating hormone associated with arterial stiffness , central systolic blood pressure , and 24-hour systolic blood pressure in males with treatment-naïve hypertension and euthyroid? | [
"We compared the results of laboratory examinations, echocardiography, arterial stiffness, central blood pressure (BP) and ambulatory BP monitoring (ABPM) between treatment-naïve patients with low normal thyroid-stimulating hormone (TSH) and those with high normal TSH levels. A total of 285 consecutively-eligible p... | [
"Left ventricular hypertrophy (LVH), a sign of subclinical cardiovascular disease, is an important predictor of cardiovascular morbidity and mortality. The aim of our study was to determine the association of left ventricular mass (LVM) with possible causative anthropometric and biochemical parameters as well as ca... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does rotenone impair autophagic flux and lysosomal functions in Parkinson 's disease? | [
"Rotenone is an environmental neurotoxin that induces accumulation of α-synuclein and degeneration of dopaminergic neurons in substantia nigra pars compacta (SNpc), but the molecular mechanisms are not fully understood. We investigated whether rotenone induced impairment of autophagic flux and lysosomal functions. ... | [
"Sirtuins connect energy generation and metabolic stress to the cellular acetylome. Currently, only the mitochondrial sirtuins (SIRT3-5) and SIRT1 have been shown to direct mitochondrial function; however, Aims: NAD-dependent protein deacetylase sirtuin-2 (SIRT2), the primary cytoplasmic sirtuin, is not yet reporte... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is interleukin-6 associated with obesity , central fat distribution , and disease severity in patients with acute pancreatitis? | [
"Acute pancreatitis (AP) is a systemic inflammatory disease, and cytokines are suggested to be related to the course of AP. Obesity and central fat distribution are considered to have been associated with severe AP. This study investigated the profile of inflammatory cytokines in AP to determine how they are relate... | [
"Omentin-1, an adipokine secreted from visceral adipose tissue, has been reported to be associated with coronary artery disease (CAD) and metabolic disorders. To clarify the relationship between serum omentin-1 levels and the presence and severity of CAD in patients with metabolic syndrome (MetS). We measured serum... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is platelet activation associated with myocardial infarction in patients with pneumonia? | [
"Troponins may be elevated in patients with pneumonia, but associations with myocardial infarction (MI) and with platelet activation are still undefined. The aim of this study was to investigate the relationship between troponin elevation and in vivo markers of platelet activation in the early phase of hospitalizat... | [
"Elevated troponin I in the absence of angiographically visible coronary lesions is seen in up to 10-15% of those undergoing angiography for suspected coronary artery disease. This study aims to elucidate the etiology of elevated cardiac troponin I in patients with normal coronary arteries on angiography. We identi... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is fasting serum dipeptidyl peptidase-4 activity independently associated with alanine aminotransferase in type 1 diabetic patients? | [
"Dipeptidyl peptidase-4 (DPP4) was recently proposed as a novel adipokine linked to insulin resistance (IR). As IR represents a cluster of disorders in hepatic and muscle cell insulin signalisation, we aimed to assess the possible correlation between fasting serum DPP4 activity, IR and liver enzymes in order to elu... | [
"In this study, circulating serum betatrophin levels were quantitated and their relationships with insulin resistance (IR) and other metabolic parameters in Chinese subjects with varying degrees of obesity and glucose tolerance were examined. Serum betatrophin levels were determined using ELISA in 60 subjects with ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is initial combination therapy with metformin , pioglitazone and exenatide more effective than sequential add-on therapy in subjects with new-onset diabetes . Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes ( EDICT ) : a randomized trial? | [
"To test our hypothesis that initiating therapy with a combination of agents known to improve insulin secretion and insulin sensitivity in subjects with new-onset diabetes would produce greater, more durable reduction in glycated haemoglobin (HbA1c) levels, while avoiding hypoglycaemia and weight gain, compared wit... | [
"The main goal of this study was to determine the effects of incretins on type 2 diabetes (T2D) remission after Roux-en-Y gastric bypass (RYGB) surgery for patients taking insulin. Type 2 diabetes is a chronic disease with potentially debilitating consequences. RYGB surgery is one of the few interventions that can ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does diet-induced obesity prevent the development of acute traumatic coagulopathy? | [
"Obesity and hemorrhagic shock following trauma are predictors of mortality but have conflicting effects on coagulation. Following hemorrhage, tissue injury and hypoperfusion lead to acute traumatic coagulopathy (ATC), producing a hypocoagulable state. Inversely, obesity promotes clotting and impairs fibrinolysis t... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do endothelial progenitor cells induce transplant arteriosclerosis via VEGFR-1/2 activity? | [
"Acute rejection (AR) after organ transplantation results in transplant arteriosclerosis (TA). Endothelial progenitor cells (EPCs) are involved in tissue repair and blood vessel formation but are suspected to be a cause of TA. In this study, we introduced a syngeneic and allogeneic abdominal aortic transplant model... | [
"Hypoxia induces expression of various genes and microRNAs (miRs) that regulate angiogenesis and vascular function. In this study, we investigated a new functional role of new hypoxia-responsive miR-101 in angiogenesis and its underlying mechanism for regulating heme oxygenase-1 (HO-1) and vascular endothelial grow... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are elevated beta2-glycoprotein I-low-density lipoprotein levels associated with the presence of diabetic microvascular complications? | [
"To investigate serum beta2-glycoprotein I-low-density lipoprotein (β2-GPI-LDL) and oxidized low-density lipoprotein (ox-LDL) levels in type 2 diabetes mellitus (T2DM) patients, and to further evaluate the associations of β2-GPI-LDL with ox-LDL in vivo and with the presence of diabetic microvascular complications. ... | [
"Connective tissue growth factor (CTGF) is strongly upregulated in fibrotic disorders and has been hypothesized to play a role in the development and progression of diabetes complications. The aim of the present study was to investigate the possible association of plasma CTGF levels in type 1 diabetic patients with... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is bone marrow from blotchy mice dispensable to regulate blood copper and aortic pathologies but required for inflammatory mediator production in LDLR-deficient mice during chronic angiotensin II infusion? | [
"The blotchy mouse caused by mutations of ATP7A develops low blood copper and aortic aneurysm and rupture. Although the aortic pathologies are believed primarily due to congenital copper deficiencies in connective tissue, perinatal copper supplementation does not produce significant therapeutic effects, hinting add... | [
"Cigarette smoking is an independent risk factor for atherosclerosis. Nicotine, the addictive component of cigarettes, induces mast cell (MC) release and contributes to atherogenesis. The purpose of this study was to determine whether nicotine accelerates atherosclerosis through MC-mediated mechanisms and whether M... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are maternal salivary cortisol levels during pregnancy positively associated with overweight children? | [
"Animal and human studies suggest that programing of the hypothalamic-pituitary-adrenal (HPA) axis may be involved in the development of obesity, but human studies of biological indicators of HPA axis activity are lacking. We studied the association between levels of the stress hormone cortisol during pregnancy and... | [
"Postnatal Depression has demonstrated long-term consequences on child cognitive and emotional development, however, the link between maternal and child pathology has not been clearly identified. This study examined whether maternal bonding to the infant and young child is impaired by maternal depressive symptoms. ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is less advanced disease at initiation of salvage androgen deprivation therapy associated with decreased mortality following biochemical failure post-salvage radiation therapy? | [
"The optimal clinical context for initiation of salvage androgen deprivation therapy (SADT) following the biochemical recurrence of localized prostate cancer remains controversial. We chose to investigate if disease burden at time of SADT initiation is associated with clinical outcomes following biochemical failure... | [
"The natural history of non-metastatic castrate refractory prostate cancer is unknown and treatment options are limited. We present a retrospective review of 13 patients with locally advanced or high risk prostate cancer, initially treated with hormone monotherapy and then treated with prostate radiation after beco... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
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Is low postoperative platelet count associated with negative outcome after liver resection for hepatocellular carcinoma? | [
"Hepatocellular carcinoma is one of the most common malignancies worldwide. The only curative treatment is surgery. As hepatocellular carcinoma is often associated with liver cirrhosis, patients are at risk for postoperative liver failure. In the recent years, platelets are thought to play an important role in live... | [
"We investigated the risk of morbidity after repeat resections for liver recurrence of hepatocellular carcinoma or for colorectal liver metastases. Although repeat hepatectomy for recurrences of hepatocellular carcinoma or for colorectal cancer liver metastases is well known only to carry risks similar to those see... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does early menarche increase the risk of Type 2 diabetes in young and middle-aged Korean women? | [
"To investigate the association between early menarche (menarche age < 12 years) and Type 2 diabetes mellitus in young and middle-aged Korean women. We analysed data for 4657 women aged 20-50 years from the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV) (2007-2009). The prevalence of Typ... | [
"High-density lipoprotein (HDL) cholesterol is a powerful cardiovascular risk factor. Important gender and ethnic differences in plasma HDL levels exist and warrant investigation. Cross-sectional survey in two different general populations. Patients 7700 participants of the National Health and Nutrition Examination... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does twenty-four hour in-hospital congenital cardiac surgical coverage improve perioperative ECMO support outcomes? | [
"Extracorporeal membrane oxygenation (ECMO) support is often required in the management of perioperative congenital heart surgery (CHS) patients. However, 24-hour in-hospital congenital cardiac surgical coverage (24-CCSC) is not available at all institutions. The purpose of this study is to evaluate the effect of 2... | [
"Fluid management during orthotopic liver transplantation poses unique challenges for the anesthesiologist. Maintenance of hypovolemia as indicated by low central venous pressure has been associated with reduced blood loss and improved outcomes in some studies, but with higher 30-day mortality and increased inciden... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does early primary repair of tetralogy of Fallot lead to increased postoperative resource utilization? | [
"Although early primary repair of tetralogy of Fallot has gained wider acceptance, there is some speculation that repair at a younger age may be associated with increased morbidity and resource utilization. A retrospective review of all consecutive patients undergoing tetralogy of Fallot repair between September 20... | [
"Women have been found to have greater mortality from coronary artery bypass grafting than men. Uncertainty exists regarding the causes of the differences in outcomes between men and women after coronary artery bypass grafting. From a database of 2,569 patients having coronary bypass grafting we have determined fac... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
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} |
Are aggregate National Early Warning Score ( NEWS ) values more important than high scores for a single vital signs parameter for discriminating the risk of adverse outcomes? | [
"The Royal College of Physicians (RCPL) National Early Warning Score (NEWS) escalates care to a doctor at NEWS values of ≥5 and when the score for any single vital sign is 3. We calculated the 24-h risk of serious clinical outcomes for vital signs observation sets with NEWS values of 3, 4 and 5, separately determin... | [
"Readmission to ICU following discharge is associated with increased length of stay (LOS), increased rates of mortality, morbidity and resource consumption. Reducing readmission rates is one of the key aims of the Intensive Care Unit liaison nurse (ICULN). Our objective was to identify factors associated with readm... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are plant communities on infertile soils less sensitive to climate change? | [
"Much evidence suggests that plant communities on infertile soils are relatively insensitive to increased water deficit caused by increasing temperature and/or decreasing precipitation. However, a multi-decadal study of community change in the western USA does not support this conclusion. This paper tests explanati... | [
"Invasive plants represent a significant threat to ecosystem biodiversity. To decrease the impacts of invasive species, a major scientific undertaking of the last few decades has been aimed at understanding the mechanisms that drive invasive plant success. Most studies and theories have focused on a single mechanis... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does licochalcone-A sensitize human esophageal carcinoma cells to TRAIL-mediated apoptosis by proteasomal degradation of XIAP? | [
"Esophageal carcinoma is one of the most aggressive human cancers, and novel treatment modality is required. Although expressing adequate levels of functional tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors DR4/DR5, significant proportion of esophageal cancer cells exhibit resistance to th... | [
"Eriocalyxin B (EriB) is a natural diterpenoid purified from Isodon eriocalyx var. laxiflora and possesses strong antileukemic activity. In this study, we further investigated its effect and mechanism of action in human lymphoma. In vitro, a series of B- and T-lymphoma cells were treated with EriB. Cell apoptosis w... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is intranodal cytokeratin particles a predictive marker of efficacy for neoadjuvant therapies in patients with squamous cell carcinoma of the esophagus? | [
"Lymph node metastasis is one of the most important prognostic factors in patients with esophageal squamous cell carcinoma (ESCC). Neoadjuvant treatment can reduce micrometastasis in lymph nodes to enable curative resection by down staging. The aim of this study was to evaluate the histological effect of neoadjuvan... | [
"Her2 (ErbB2) transforms cells when overexpressed and is an important therapeutic target in breast cancer. Contrary to breast cancer, studies on Her2 overexpression and gene amplification in squamous cell carcinomas of the head and neck region described largely different results. This study was undertaken to learn ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does iNKT/CD1d-antitumor immunotherapy significantly increase the efficacy of therapeutic CpG/peptide-based cancer vaccine? | [
"Therapeutic cancer vaccines aim to boost the natural immunity against transformed cancer cells, and a series of adjuvants and co-stimulatory molecules have been proposed to enhance the immune response against weak self-antigens expressed on cancer cells. For instance, a peptide/CpG-based cancer vaccine has been ev... | [
"Neuroblastoma is a pediatric cancer of neural crest origin. Despite aggressive treatment, mortality remains at 40 % for patients with high-risk disseminated disease, underscoring the need to test new combinations of therapies. In murine tumor models, our laboratory previously showed that T cell-mediated anti-tumor... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is pseudomonas aeruginosa in CF and non-CF homes found predominantly in drains? | [
"For patients with cystic fibrosis (CF) Pseudomonas aeruginosa infection is a major contributor to progressive lung disease. While colonizing strains are thought to be primarily environmental, which environments are important in lung colonization is unclear. We took 11,674 samples from a broad range of sites over 3... | [
"Patients and their surroundings are known reservoirs for nosocomial pathogens. Enteral feeding tubes and formula are not thought of as reservoirs for nosocomial organisms. A prospective observation study was conducted comparing methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcu... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is increased expression of pleiotrophin a prognostic marker for patients with gastric cancer? | [
"BACKGROUND/AIMs: Pleiotrophin (PTN) have been demonstrated to play an important role in the development of human gastric cancer. However, the prognostic value remains unclear. The aim of this study was to investigate whether expression of PTN has prognostic relevance in human gastric cancer. Immunohistochemistry w... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does the CC-genotype of the cyclooxygenase-2 gene associate with decreased risk of nasopharyngeal carcinoma in a Tunisian population? | [
"The cyclooxygenase-2 (cox-2) pathway is now recognized to be important in human cancer development and progression. The gene for cox-2 carries a common single nucleotide polymorphism, T8473C, located within a potential functional region in the 3'-UTR of cox-2 gene was identified. We have investigated the frequenci... | [
"We investigated the associations between -174 G/C polymorphism of interleukin-6 (IL-6) gene promoter and serum IL-6 and carcinoembryonic antigen (CEA) levels in Taiwanese patients with colorectal cancer (CRC)."
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does a shoe insole delivering subsensory vibratory noise improve balance and gait in healthy elderly people? | [
"To test whether subsensory vibratory noise applied to the sole of the foot using a novel piezoelectric vibratory insole can significantly improve sensation, enhance balance, and reduce gait variability in elderly people, as well as to determine the optimal level of vibratory noise and whether the therapeutic effec... | [
"To investigate the effects of long-term Tai Chi practice on balance control when healthy elderly Tai Chi practitioners stood under reduced or conflicting somatosensory, visual, and vestibular conditions, as compared with healthy elderly non-Tai Chi practitioners and young subjects. Cross-sectional study. Universit... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do sleep spindle and slow wave frequency reflect motor skill performance in primary school-age children? | [
"The role of sleep in the enhancement of motor skills has been studied extensively in adults. We aimed to determine involvement of sleep and characteristics of spindles and slow waves in a motor skill in children. We hypothesized sleep-dependence of skill enhancement and an association of interindividual difference... | [
"Recent evidence suggests that the sleep-dependent consolidation of declarative memory relies on the nonrapid eye movement rather than the rapid eye movement phase of sleep. In addition, it is known that aging is accompanied by changes in sleep and memory processes. Hence, the purpose of this study was to investiga... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does the dual CCR5 and CCR2 inhibitor cenicriviroc redistribute HIV into extracellular space : implications for plasma viral load and intracellular DNA decline? | [
"Cenicriviroc is a potent antagonist of the chemokine coreceptors 5 and 2 (CCR5/CCR2) and blocks HIV-1 entry. The CCR5 inhibitor maraviroc has been shown in tissue culture to be able to repel cell-free virions from the cell surface into extracellular space. We hypothesized that cenicriviroc might exhibit a similar ... | [
"Efficacy assessment of AIDS vaccines relies both on preclinically challenging immunized monkeys with simian immunodeficiency virus (SIV) or monitoring infection rates in large human trials. Although conventional parameters of vaccine-induced immune responses do not completely predict outcome, existing methods for ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do our experiences on the reconstruction of lateral scalp burn alopecia with tissue expanders? | [
"Cicatricial alopecia is a form of hair loss that causes both cosmetic and psychological concerns. Although tissue expanders are the common approach to reconstruction, no algorithm exists in the literature for this process. In this study, it was aimed to create an algorithm for the reconstruction of lateral scalp a... | [
"Treatment of extraordinarily large deep burns remains a huge clinical challenge. This article is a summary of our experience with the treatment of a patient with an extraordinarily large deep burn (99.5% TBSA and 23% fourth degree burn) by using the \"microskin autografting and alloskin repeated grafting\" method ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is prostate-specific antigen doubling time subsequent to radical prostatectomy a predictor of outcome following salvage external beam radiation therapy : a single-centre experience? | [
"The aim of this study was to review the impact of salvage external beam radiotherapy (EBRT) of postprostatectomy patients with long-term follow-up on biochemical-free recurrence (BFR) and metastatic-free survival, and to describe pathological and clinical predictors of outcome. In the period 1987-2010, 76 postpros... | [
"I review the data published during the last 5 years on the effects of early treatment of prostate cancer on survival. Data from prospective and randomized studies as well as from population-based studies are presented. Two studies (European Organization for Research and Treatment of Cancer and Radiation Therapy On... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is head-shaft angle a risk factor for hip displacement in children with cerebral palsy? | [
"Hip dislocation in children with cerebral palsy (CP) is a common and severe problem. The Swedish follow-up program for CP (CPUP) includes standardized monitoring of the hips. Migration percentage (MP) is a widely accepted measure of hip displacement. Coxa valga and valgus of the femoral head in relation to the fem... | [
"Hyaluronan (HA) was measured in cerebrospinal fluid (CSF) to ascertain the clinical significance of this substance in patients with spinal disorders, a topic that, to the best of our knowledge, has not previously been studied. We examined correlations of CSF HA concentration with age, sex, height, body weight, and... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is implementation of a surgical intensive care unit service associated with improved outcomes for trauma patients? | [
"Our trauma service recently transitioned from a pulmonary intensive care unit (ICU) service to a surgical ICU (SICU) service. We hypothesized that a newly formed SICU service could provide comparable outcomes to the existing pulmonary ICU service. A specific aim of this study was to compare outcomes of trauma pati... | [
"Hip fracture in geriatric patients has a substantial economic impact and represents a major cause of morbidity and mortality in this population. At our institution, a regional anesthesia program was instituted for patients undergoing surgery for hip fracture. This retrospective cohort review examines the effects o... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does elevated amygdala activity during reappraisal anticipation predict anxiety in avoidant personality disorder? | [
"Avoidant personality disorder is characterized by pervasive anxiety, fear of criticism, disapproval, and rejection, particularly in anticipation of exposure to social situations. An important but underexplored question concerns whether anxiety in avoidant patients is associated with an impaired ability to engage e... | [
"Traumatic exposure may modulate the expression of impulsive behavioral dispositions and change the implementation of emotion regulation strategies associated with depressive mood. Past studies resulted in only limited comprehension of these relationships, especially because they failed to consider impulsivity as a... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does prenatal marijuana exposure predict marijuana use in young adulthood? | [
"Studies have reported effects of prenatal marijuana exposure (PME) on cognitive and behavioral outcomes. An earlier publication from this study found that PME predicted early onset of marijuana use and frequency of marijuana use at age 14. No study has reported the effects of PME on marijuana use in young adulthoo... | [
"Do teenage girls with a history of menstrual irregularity and/or elevated androgen levels in adolescence exhibit an increased risk of polycystic ovary syndrome (PCOS) and/or infertility later on in adulthood?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does nAIF1 inhibit gastric cancer cells migration and invasion via the MAPK pathways? | [
"Nuclear apoptosis-inducing factor 1 (NAIF1) could induce apoptosis in gastric cancer cells. Previously, we have reported that the expression of NAIF1 protein is down-regulated in gastric cancer tissues compared with the adjacent normal tissues. However, the role of NAIF1 in gastric cancer cells is not fully unders... | [
"To examine the antiproliferation and anti-invasion of Eupolyphaga sinensis Walker 70% ethanol extract (ESWE) on breast cancer and elucidate the underlying signaling mechanisms. MTT and colony formation assays were used to investigate the effect of ESWE on proliferation of breast cancer cells in vitro. The xenograf... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is cMV specific cytokine release assay in whole blood optimized by combining synthetic CMV peptides and toll like receptor agonists? | [
"Interferon gamma release assays (IGRAs) are widely used to detect pathogen specific cellular immunity. Cytomegalovirus (CMV) is the foremost problematic viral infection in immunocompromised patients such as transplant or HIV infected patients. CMV antibody ELISAs are not able to predict CMV specific cellular immun... | [
"Upper respiratory tract infection is a frequent cause of morbidity worldwide. Although the course of infection is usually mild, it is responsible for enormous social and economic costs. Immunostimulation with bacterial extracts consisting of ribosomal RNA and proteoglycans, such as Ribomunyl, was introduced into t... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does light alcohol consumption play a protective role against non-alcoholic fatty liver disease in Japanese men with metabolic syndrome? | [
"Although excess alcohol consumption has been believed to cause liver injury, light alcohol consumption (LAC) has been reported to play a protective role against fatty liver in recent studies. However, the association between non-alcoholic fatty liver disease (NAFLD) and LAC in men with metabolic syndrome (MS) is u... | [
"To clarify the clinical characteristics of type 2 diabetic patients with non-alcoholic fatty liver disease (NAFLD) and to assess whether NAFLD is related to angiopathy. The study included 388 Japanese type 2 diabetic outpatients without viral hepatitis. The main outcome measures were angiopathy and NAFLD. The 388 ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do genomic selection accuracies within and between environments and small breeding groups in white spruce? | [
"Genomic selection (GS) may improve selection response over conventional pedigree-based selection if markers capture more detailed information than pedigrees in recently domesticated tree species and/or make it more cost effective. Genomic prediction accuracies using 1748 trees and 6932 SNPs representative of as ma... | [
"Heterosis describes the superior phenotypes observed in hybrids relative to their inbred parents. Maize is a model system for studying heterosis due to the high levels of yield heterosis and commercial use of hybrids. The inbred lines from an association mapping panel were crossed to a common inbred line, B73, to ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do local and general anaesthesia influence outcome of transfemoral aortic valve implantation? | [
"There is great variability for the type of anaesthesia used during TAVI, with no clear consensus coming from comparative studies or guidelines. We sought to detect regional differences in the anaesthetic management of patients undergoing transcatheter aortic valve implantation (TAVI) in Europe and to evaluate the ... | [
"Statins are an essential component of the therapeutic approach of patients with atherosclerotic disease. Statin use is also associated with improved peri-operative and long-term outcomes in these patients. We aimed to define the role of statin treatment in patients undergoing percutaneous revascularization procedu... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does multidrug resistant bacteriuria before percutaneous nephrolithotomy predict for postoperative infectious complications? | [
"Multidrug resistant (MDR) uropathogens are increasing in prevalence and may contribute to significant morbidity after percutaneous nephrolithotomy (PCNL). We investigate the presence of MDR bacteriuria and occurrence of postoperative infectious complications in patients who underwent PCNL at our institution. Retro... | [
"To evaluate urologic complications after colorectal resection for endometriosis. Cohort study (Canadian Task Force classification II-2). Tertiary referral university hospital and expert center in endometriosis. One hundred sixty-six women with colorectal endometriosis proven by transvaginal sonography and magnetic... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is higher fibrinogen level independently linked with the presence and severity of new-onset coronary atherosclerosis among Han Chinese population? | [
"Fibrinogen is a coagulation/inflammatory biomarker strongly associated with atherogenesis. However, no data is currently available regarding the association of fibrinogen level with the presence and severity of new-onset coronary atherosclerosis assessed by Gensini score (GS), particularly in Han Chinese with a la... | [
"Endothelial dysfunction is one of the most important early indicators of atherosclerosis in hypertension (HT) patients. Endocan has been reported to play a role in the pathophysiology of endothelial dysfunction. We sought to assess whether serum endocan levels are correlated with the presence and severity of coron... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is the combination of pill count and self-reported adherence a strong predictor of first-line ART failure for adults in South Africa? | [
"Suboptimal adherence to antiretroviral therapy (ART) is a strong predictor of virologic failure (VF) among people with HIV. Various methods such as patient self-report, pill counts and pharmacy refills have been utilized to monitor adherence. However, there are limited data on the accuracy of combining methods to ... | [
"Antiretroviral therapy (ART) initiation in eligible HIV-infected pregnant women is an important intervention to promote maternal and child health. Increasing the duration of ART received before delivery plays a major role in preventing vertical HIV transmission, but pregnant women across Africa experience signific... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does microRNA-19a enhance proliferation of bronchial epithelial cells by targeting TGFβR2 gene in severe asthma? | [
"Allergic asthma is characterized by inflammation and airway remodeling. Bronchial epithelium is considered a key player in coordinating airway wall remodeling. In mild asthma, the epithelium is damaged and fails to proliferate and to repair, whereas in severe asthma, the epithelium is highly proliferative and thic... | [
"Epithelial-mesenchymal transition (EMT) is the major pathophysiological process in lung fibrosis observed in chronic obstructive pulmonary disease (COPD) and lung cancer. Smoking is a risk factor for developing EMT, yet the mechanism remains largely unknown. In this study, we investigated the role of Rac1 in cigar... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are serum triglycerides , but not cholesterol or leptin , decreased in suicide attempters with mood disorders? | [
"Many peripheral biomarkers, including low cholesterol and its fractions, have been examined to identify suicidal behavior. Herein, we assessed serum lipid profile and some proteins putatively associated with suicidal behavior in subjects with mood disorder (bipolar disorder or major depressive disorder) with a rec... | [
"Glucagon-like peptide-1 (GLP-1) is an incretin hormone that has a wide range of effects on glucose metabolism and cardiovascular function (e.g., improving insulin sensitivity, reduction in appetite, modulation of heart rate, blood pressure and myocardial contractility). Metabolic syndrome (MetS) is associated with... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is soft drink consumption associated with depressive symptoms among adults in China? | [
"Research evidence supports a positive link between soft drinks and depressive symptoms. However, data thus far are only from Caucasian populations. We investigated whether high levels of consumption of soft drinks were associated with the depressive symptoms among adults in China. A cross-sectional survey was cond... | [
"What are the associations between the dietary intake of antioxidant nutrients and semen parameters in young men?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is blood alcohol concentration negatively associated with gambling money won on the Iowa gambling task in naturalistic settings after controlling for trait impulsivity and alcohol tolerance? | [
"Acute alcohol intoxication has been found to increase perseverative errors on the Wisconsin Card Sorting Test, a well known neuropsychological index of prefrontal cortical functioning, in both laboratory and naturalistic settings. The present study examined the relationship between levels of alcohol consumption at... | [
"Reward deprivation has been implicated in major depressive disorder and severe substance abuse, but its potential relation to alcohol use disorder (AUD) symptoms in non-treatment-seeking young adult drinkers is less clear. Depression is often comorbid with alcohol misuse, so relations of AUD with reward deprivatio... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does sexual activity predispose to reflux episodes in patients with gastroesophageal reflux disease? | [
"The role of sexual activity on gastroesophageal reflux disease (GERD) is an under-recognized concern of patients, and one rarely assessed by physicians. The objective of this article is to determine the influence of sexual activity on the intraesophageal acid exposure and acid reflux events in GERD patients. Twent... | [
"The relationship between Helicobacter pylori infection and gastro-oesophageal reflux disease is complicated. Evidence does not support a causal link. There have been reports, which have implicated successful eradication of Helicobacter pylori, in patients with a duodenal ulcer, with the subsequent development of g... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is vascular injury associated with increased mortality in winter sports trauma? | [
"Trauma is the leading cause of injury and death for individuals aged 1-44 years. Up to 8% of the US population participates in winter sports, and although vascular injuries are uncommon in these activities, little is published in this area. We sought to identify the incidence, injury patterns, and outcomes of vasc... | [
"Traumatic brain injury results in significant morbidity and mortality and is associated with infectious complications, particularly pneumonia. However, whether traumatic brain injury directly impacts the host response to pneumonia is unknown. The objective of this study was to determine the nature of the relations... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is a common variant in RAB27A gene associated with fractional exhaled nitric oxide levels in adults? | [
"Exhaled nitric oxide (FeNO) is a biomarker for eosinophilic inflammation in the airways and for responsiveness to corticosteroids in asthmatics. We sought to identify in adults the genetic determinants of fractional exhaled nitric oxide (FeNO) levels and to assess whether environmental and disease-related factors ... | [
"Cystic fibrosis (CF) affects the lungs causing infections and inflammation. Surfactant protein D (SP-D) is an innate defense lectin primarily secreted in the lungs. We investigated the influence of the SP-D Met11Thr polymorphism on CF lung function; and serum SP-D as a marker for CF lung disease. For 107 CF patien... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does a dietary phytochemical blend prevent liver damage associated with adipose tissue mobilization in ovariectomized rats? | [
"Menopausal reduction in estrogen causes increased adipose accumulation, leading many to turn to dietary supplements to prevent and treat such changes. Enhanced adipose mobilization stimulated by some supplements can increase the risk of non-alcoholic fatty liver disease (NAFLD). Cytoprotective and anti-obesity com... | [
"long-term ovariectomy-induced metabolic changes such as insulin resistance and glucose intolerance might be caused directly by estrogen deficiency and may occur partly as secondary effects of obesity arising due to the orexigenic effects of estrogen deficiency. Long-term estrogen treatment prevented those by exert... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is real-time three-dimensional transesophageal echocardiography useful for percutaneous closure of multiple secundum atrial septal defects? | [
"The purpose of this study was to investigate the clinical value of real-time three-dimensional transesophageal echocardiography (RT-3D-TEE) for percutaneous transcatheter closure of multiple secundum atrial septal defects (ASDs) using a Chinese domestic occluder device. From July 2008 to September 2011, 37 patient... | [
"Long-term survival after atrioventricular septal defect repair is excellent; however, postoperative left atrioventricular valve regurgitation affects morbidity and quality of life. Left atrioventricular valve regurgitation is the most common reason for reoperation after repair and it is critical that clinicians re... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do longitudinal patterns of cortisol regulation differ in maltreated and nonmaltreated children? | [
"Child maltreatment is associated with dysregulation of stress-mediating systems and an increased risk of mental and physical health problems. Specifically, disruptions in hypothalamic-pituitary-adrenal (HPA) axis regulation have been reported in maltreated children. The current study investigates whether increased... | [
"Adult posttraumatic stress symptoms and a biomarker index of current health risk in childhood sexual abuse (CSA) survivors were investigated in relation to CSA severity, disclosure, and other peri- and post-trauma factors. A community sample of 94 African American and Latina female CSA survivors was assessed. Seve... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does substance Use and Related harm Among Adolescents With and Without Traumatic Brain Injury? | [
"The relationship between self-reported lifetime traumatic brain injury (TBI) and drug and alcohol use and associated harms was examined using an epidemiological sample of Canadian adolescents. Data were derived from a 2011 population-based cross-sectional school survey, which included 6383 Ontario 9th-12th graders... | [
"Parents often accompany adolescent and young adult (AYA) pediatric cancer survivors to follow-up oncology clinic visits and remain involved in their care, although little is known about their reasons for doing so. This mixed methods (qualitative-quantitative) study of 76 mothers of AYA survivors of childhood cance... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is eGFR-TKI effective regardless of treatment timing in pulmonary adenocarcinoma with EGFR mutation? | [
"Although epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have become key therapeutic agents for non-small cell lung cancer (NSCLC) patients with EGFR mutation, little is known about the efficacy of EGFR-TKIs according to different treatment timings. A total of 1,250 patients with NSCLC were... | [
"The KRAS mutation has been associated with resistance to cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, in metastatic colorectal cancer (mCRC). However, the predictive biomarkers of cetuximab resistance in KRAS wild-type mCRC remain unknown except BRAF, NRAS, and PIK3CA exon 20. Th... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is diabetes associated with increased risk of venous thromboembolism : a systematic review and meta-analysis? | [
"Increasing evidence suggests an association between diabetes and risk of venous thromboembolism (VTE); however, the results are inconsistent. We conducted a systematic review and meta-analysis of all epidemiological evidence to clarify association of diabetes with risk of VTE. We searched MEDLINE and EMBASE to ret... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is invasion of uterine cervical squamous cell carcinoma cells facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta? | [
"Local invasion is a common pattern of spread in uterine cervical squamous cell carcinoma (CSCC). Although transforming growth factor-beta (TGF-β) facilitates invasion of various types of cancer cells, the role of the TGF-β pathway in CSCC is unclear. In this study, we analyzed the role of TGF-β signaling in the pr... | [
"The role of polymorphonuclear granulocyte (PMN) infiltration in tumor remains unclear in esophageal cancer (EC). We conducted a retrospective study on consecutive patients with primary squamous EC. The potential roles of PMN infiltration into tumor nests were assessed by immunohistochemistry. The interactions of P... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is increased serum cancer antigen-125 a marker for severity of deep endometriosis? | [
"To determine whether cancer antigen-125 (CA-125) levels are increased in women with endometriosis, especially in those with endometriomas (OMAs), deep infiltrating lesions (DIE), and superficial endometriosis (SUP) compared with controls without endometriosis in a large cohort of operated women. Cross-sectional st... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities? | [
"We examined the phenotype and function of lymphocytes collected from the peripheral blood (PBL) and tumor (TIL) of patients with two different solid malignancies: colorectal cancer liver metastases (CRLM) and ovarian cancer (OVC). Tumor and corresponding peripheral blood were collected from 16 CRLM and 22 OVC pati... | [
"RECQ helicase family members act as guardians of the genome to assure proper DNA metabolism in response to genotoxic stress. Hematological malignancies are characterized by genomic instability that is possibly related to underlying defects in DNA repair of genomic stability maintenance. We have investigated the ex... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do long-term lung cancer survivors have permanently decreased quality of life after surgery? | [
"Retrospective evaluation of the long-term health-related quality of life (HRQoL) among survivors after non-small-cell lung cancer (NSCLC) surgery. A total of 586 patients underwent surgery for NSCLC in Helsinki University Central Hospital between January 2000 and June 2009. Two validated quality-of-life questionna... | [
"In elderly patients with mild cognitive impairment, noncompliance with respiratory exercises, ineffective expectoration, reluctance in mobilization, and difficulty in learning the use of drugs such as inhalers were observed in the early postoperative period after coronary artery bypass graft surgery. It was hypoth... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does pregestational maternal obesity impair endocrine pancreas in male F1 and F2 progeny? | [
"The aim of this study was to evaluate the effects of maternal obesity on pancreas structure and carbohydrate metabolism in early adult life, focusing on the F1 and F2 generations after F0 maternal pregestational, gestation, and lactation high-fat diet (HF). C57 BL/6 female mice (F0) were fed standard chow (SC) or ... | [
"Gestational diabetes mellitus (GDM) is a disease often manifests in mid to late pregnancy with symptoms including hyperglycemia, insulin resistance and fetal mal-development. The C57BL/KsJ-Lep (db/+) (db/+) mouse is a genetic GDM model that closely mimicked human GDM symptoms. Resveratrol (RV) is a naturally exist... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does chloroquine enhance temozolomide cytotoxicity in malignant gliomas by blocking autophagy? | [
"In a recent clinical trial, patients with newly diagnosed glioblastoma multiforme benefited from chloroquine (CQ) in combination with conventional therapy (resection, temozolomide [TMZ], and radiation therapy). In the present study, the authors report the mechanism by which CQ enhances the therapeutic efficacy of ... | [
"Ovarian cancer is commonly treated with cisplatin/paclitaxel but many tumors become resistant. Acetaminophen reduced glutathione and enhanced chemotherapy efficacy in hepatic cancer treatment. The objective of this study was to examine if acetaminophen enhances the cytotoxicity of cisplatin/paclitaxel in ovarian c... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is long-term therapy with temozolomide a feasible option for newly diagnosed glioblastoma : a single-institution experience with as many as 101 temozolomide cycles? | [
"The objective of this study was to report the authors' experience with the long-term administration of temozolomide (TMZ; > 6 cycles, up to 101) in patients with newly diagnosed glioblastoma and to analyze its feasibility and safety as well as its impact on survival. The authors also compared data obtained from th... | [
"Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) have been implicated in tumorigenesis of gliomas. Patients with high-grade astrocytomas with IDH1 or IDH2 mutations were reported to have a better survival, but it is unknown if this improved survival also holds for low-grade astrocytoma and whether the... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is thiazide-induced hyponatraemia associated with increased water intake and impaired urea-mediated water excretion at low plasma antidiuretic hormone and urine aquaporin-2? | [
"Hyponatraemia is a common, potentially life-threatening, complication of thiazide diuretics. The mechanism of thiazide-induced hyponatraemia is incompletely understood. Previous experiments have suggested a direct effect of thiazide diuretics on the plasma membrane expression of aquaporin (AQP)2. We examined the e... | [
"We investigated the effect of imipramine on nocturnal urine output in patients with nocturnal enuresis. There were 15 monosymptomatic enuretic patients 15 to 37 years and 8 control subjects 25 to 32 years old. We measured nocturnal urine output, urine osmolality, creatinine clearance, osmolal clearance, free water... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is weight based heparin dosing for thromboembolic disease associated with earlier anticoagulation in surgical patients? | [
"Achievement of early therapeutic anticoagulation with unfractionated heparin (UFH) is associated with improved outcomes in thromboembolic disease. Weight based UFH expedites time to therapeutic anticoagulation. Treatment with UFH is challenging in surgical patients due to their high propensity for bleeding. We sou... | [
"Antiplatelet drug resistance has been associated with thromboembolic complications in patients after coronary stent placement. It has not been well-studied in patients who have neurovascular stent-placement procedures. This study aimed to analyze the relationship between antiplatelet drug resistance and neurovascu... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does prospective international cohort study demonstrate inability of interim PET to predict treatment failure in diffuse large B-cell lymphoma? | [
"The International Atomic Energy Agency sponsored a large, multinational, prospective study to further define PET for risk stratification of diffuse large B-cell lymphoma and to test the hypothesis that international biological diversity or diversity of healthcare systems may influence the kinetics of treatment res... | [
"Antigen expression by neoplastic cells is important because of its effects on the behavior and survival of patients. We sought to gather data on renal transplant recipients who had developed posttransplant lymphoproliferative disorders in their posttransplant era, and had a documented report on CD20 antigen testin... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does fungal metabolite myriocin promote human herpes simplex virus-2 infection? | [
"Myriocin is a fungal metabolite with antiviral activity, including influenza, hepatitis B, and hepatitis C viruses. We investigated whether myriocin has activity against human HSV-2, one of the most prevalent pathogens of sexually transmitted disease. Cell culture systems were used to evaluate myriocin effect on H... | [
"The major psychoactive cannabinoid compound of marijuana, delta-9 tetrahydrocannabinol (THC), has been shown to modulate immune responses and lymphocyte function. After primary infection the viral DNA genome of gamma herpesviruses persists in lymphoid cell nuclei in a latent episomal circular form. In response to ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does prenatal zinc reduce stress response in adult rat offspring exposed to lipopolysaccharide during gestation? | [
"Previous investigations by our group have shown that prenatal treatment with lipopolysaccharide (LPS; 100 μg/kg, intraperitoneally) on gestation day (GD) 9.5 in rats, which mimics infections by Gram-negative bacteria, induces short- and long-term behavioral and neuroimmune changes in the offspring. Because LPS ind... | [
"Allopregnanolone is a neurosteroid produced in the brain that can alter the excitability of the CNS. Neurosteroids have neuroprotective properties, and their elevation in response to stress may protect the newborn brain following infection or hypoxia. Infection, particularly of the respiratory tract, may lead to e... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are global histone H3 lysine 27 triple methylation levels reduced in vessels with advanced atherosclerotic plaques? | [
"Alterations in epigenetic processes are frequently noted in human disease. These epigenetic processes involve methylation of DNA and post-translational modifications of histones. It is well established that in particular histone methylation plays a key role in gene transcription. In this study, we have investigate... | [
"The Tie2/angiopoietin (Tie2/Ang) and vascular endothelial growth factor receptor-ligand systems (VEGFR/VEGF) are recognized to play important roles in the regulation of microvascular endothelial function. Downregulation of these genes during sepsis has been implicated in the pathogenesis of sepsis-related microvas... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does corn silk maysin induce apoptotic cell death in PC-3 prostate cancer cells via mitochondria-dependent pathway? | [
"Despite recent advances in prostate cancer diagnostics and therapeutics, the overall survival rate still remains low. This study was aimed to assess potential anti-cancer activity of maysin, a major flavonoid of corn silk (CS, Zea mays L.), in androgen-independent human prostate cancer cells (PC-3). Maysin was iso... | [
"Mycoplasma ovipneumoniae (M. ovipneumoniae) is a species of Mycoplasma bacteria that specifically infects sheep and goat, causing ovine infectious pleuropneumonia. However, the mechanism underlying the pathogen-host interaction between M. ovipneumoniae and airway epithelial cells is unknown. A primary air-liquid i... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do some Strychnos spinosa ( Loganiaceae ) leaf extracts and fractions have good antimicrobial activities and low cytotoxicities? | [
"Strychnos spinosa Lam. is a deciduous tree used in traditional medicine to treat infectious diseases. This study is designed to determine the antimicrobial, antioxidant and cytotoxic activities of extracts and fractions from leaves of S. spinosa. Extracts were obtained by maceration with acetone, methanol and dich... | [
"Some studies have reported that different parts of pomegranate fruit, especially the peel, may act as potential antimicrobial agent and then they might be proposed as safe natural source alternatives to synthetic antimicrobial agents. The high tannins content, especially punicalagin, found in pomegranate extracts,... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does maternal immune activation in nonhuman primates alter social attention in juvenile offspring? | [
"Sickness during pregnancy is associated with an increased risk of offspring neurodevelopmental disorders. Rodent models have played a critical role in establishing causal relationships and identifying mechanisms of altered brain and behavior development in pups prenatally exposed to maternal immune activation (MIA... | [
"Accumulating evidence from a relatively small number of prospective studies indicates that exposure to prenatal stress profoundly influences the developing human fetus with consequences that persist into childhood and very likely forever. Maternal/fetal dyads are assessed at ∼20, ∼25, ∼31 and ∼36 weeks of gestatio... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does atractylodes macrocephala Koidz stimulate intestinal epithelial cell migration through a polyamine dependent mechanism? | [
"Atractylodes macrocephala Koidz (AMK), a valuable traditional Chinese herbal medicine, has been widely used in clinical practice for treating patients with disorders of the digestive system. AMK has shown noteworthy promoting effect on improving gastrointestinal function and immunity, which might represent a promi... | [
"To evaluate the effects of oligonol administration on experimentally induced colitis and colonic adenoma formation. Oral administration of oligonol protected against mouse colitis induced by dextran sulfate sodium (DSS). Under the same experimental conditions, oligonol administration significantly inhibited the ac... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does chronic exercise normalize changes in Cav 1.2 and KCa 1.1 channels in mesenteric arteries from spontaneously hypertensive rats? | [
"Regular physical activity is an effective non-pharmacological therapy for prevention and control of hypertension. However, the underlying mechanisms are not fully understood. Accumulating evidence shows that the elevated vascular tone in hypertension is a consequence of the 'ion channel remodelling' that occurs du... | [
"Obesity and Type 2 diabetes mellitus (DM) induce left ventricular (LV) diastolic dysfunction, which contributes to an increasing prevalence of heart failure with a preserved LV ejection fraction. We investigated the effects of sitagliptin (SITA), an inhibitor of dipeptidylpeptidase-4 (DPP-4) and anti-diabetic drug... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does cXCR3 antagonist VUF10085 bound to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779? | [
"The chemokine receptor CXCR3 is implicated in a variety of clinically important diseases, notably rheumatoid arthritis and atherosclerosis. Consequently, antagonists of CXCR3 are of therapeutic interest. In this study, we set out to characterize binding sites of the specific low MW CXCR3 antagonist VUF10085 and th... | [
"Proteinase-activated receptor-2 (PAR2) is a GPCR linked to diverse pathologies, including acute and chronic pain. PAR2 is one of the four PARs that are activated by proteolytic cleavage of the extracellular amino terminus, resulting in an exposed, tethered peptide agonist. Several peptide and peptidomimetic agonis... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
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