query stringlengths 17 395 | pos list | neg list | task stringclasses 1
value | instruction dict |
|---|---|---|---|---|
Does global cortical thinning in acute anorexia nervosa normalize following long-term weight restoration? | [
"Anorexia nervosa (AN) is a serious eating disorder characterized by self-starvation, extreme weight loss, and alterations in brain structure. Structural magnetic resonance imaging studies have documented brain volume reductions in acute AN, but it is unclear whether they are 1) regionally specific, or 2) reversibl... | [
"Epidemiologic and clinical studies suggest comorbidity between major depressive disorder (MDD) and obesity. To elucidate the impact of weight on the course of depression beyond comorbidity, we investigated psychopathology, attention, neuroendocrinology, weight change, and treatment response in MDD patients, depend... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are symptoms in severe aortic stenosis associated with decreased compensatory circumferential myocardial mechanics? | [
"Symptomatic patients with severe aortic stenosis (AS) demonstrate abnormal left ventricular (LV) mechanics. The aim of this study was to compare mechanics in asymptomatic and symptomatic patients with severe AS using two-dimensional myocardial strain imaging. One hundred fifty-four patients with severe AS (aortic ... | [
"There is a growing population of adults with repaired cyanotic congenital heart disease. These patients have increased risk of impaired cardiac health and premature death. We hypothesized that hypoxia in early life before surgical intervention causes lasting changes in left ventricular structure and function with ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does negative affectivity predict decreased pain tolerance during low-grade inflammation in healthy women? | [
"Experimental animal studies provided evidence for a synergistic effect of immunological and psychological stressors on subsequent sickness behaviours. Up to now, little corroborating evidence for such synergy exists for humans, in whom it may provide a mechanism leading to the expression of functional somatic symp... | [
"Since returning from the Persian Gulf, nearly 100,000 veterans of the first Gulf War (GVs) have reported numerous symptoms with no apparent medical explanation. A primary complaint of these individuals is chronic musculoskeletal pain (CMP). CMP symptoms in GVs are similar to those reported by patients with fibromy... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does regulator of the mucoid phenotype A gene increase the virulent ability of extended-spectrum beta-lactamase-producing serotype non-K1/K2 Klebsiella pneumonia? | [
"To determine whether the presence of a capsule regulator gene [i.e., regulator of mucoid phenotype A (rmpA) gene] contributes to virulence on extended-spectrum β-lactamase-producing Klebsiella pneumoniae (ESBL-KP) with serotype non-K1/K2 strains. Twenty-eight ESBL-KP and non-ESBL-KP isolates were collected from th... | [
"This study was designed to characterize urinary isolates of Escherichia coli that produce extended-spectrum beta-lactamases (ESBLs) and to determine the prevalence of other antimicrobial resistance genes. A total of 264 non-duplicate clinical isolates of E. coli were recovered from urine specimens in a tertiary-ca... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does chronic psychological stress in high-anxiety rats induce sustained bladder hyperalgesia? | [
"To evaluate whether anxiety-prone rats exposed to chronic water avoidance stress (WAS) develop visceral bladder hyperalgesia in addition to increased voiding frequency and anxiety-related behaviors. Female Wistar-Kyoto (WKY) rats were exposed to chronic (10-day) WAS or sham paradigms. Referred hyperalgesia and tac... | [
"Injury- or disease-induced artemin (ARTN) signaling can sensitize primary afferents and contribute to persistent pain. We demonstrate that administration of an ARTN neutralizing antibody, anti-artemin (α-ARTN), can block the development of, and reverse already established, bladder hyperalgesia associated with cycl... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does experimental sleep restriction cause endothelial dysfunction in healthy humans? | [
"Epidemiologic evidence suggests a link between short sleep duration and cardiovascular risk, although the nature of any relationship and mechanisms remain unclear. Short sleep duration has also been linked to an increase in cardiovascular events. Endothelial dysfunction has itself been implicated as a mediator of ... | [
"Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are chronic pancreatitis pain pattern and severity independent of abdominal imaging findings? | [
"Chronic pancreatitis is characterized by inflammation, atrophy, fibrosis with progressive ductal changes, and functional changes that include variable exocrine and endocrine insufficiency and multiple patterns of pain. We investigated whether abdominal imaging features accurately predict patterns of pain. We colle... | [
"Kawasaki disease (KD) is an acute systematic vasculitis in children which causes coronary arterial lesions and hydrops of gallbladder. Our objective is to correlate the clinical significance and influence on disease outcome of patients with gallbladder abnormalities in Kawasaki dissease. Children who met KD diagno... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is postural change during venous blood collection a major source of bias in clinical chemistry testing? | [
"To investigate the influence of different phlebotomy postures on clinical chemistry testing. Nineteen volunteers were recruited from the laboratory staff. A first set of samples was drawn after 25 min of resting in supine position, a second after 20 min in sitting position, and a third after 20 min in upright posi... | [
"To evaluate whether calcium adjusted for albumin can be used to monitor calcium homeostasis in critically ill patients. Prospective single-single center observational study. Clinical laboratory and critical care unit of a regional teaching hospital. Fifty-three paired samples were from 36 patients requiring intens... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are novel mutations in the displacement loop of mitochondrial DNA associated with acute lymphoblastic leukemia : a genetic sequencing study? | [
"Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children and represents approximately 25% of cancer diagnoses among those younger than 15 years of age. This study investigated alterations in the displacement loop (d-loop) region of mitochondrial DNA (mtDNA) as a risk factor and diagnostic... | [
"RECQ helicase family members act as guardians of the genome to assure proper DNA metabolism in response to genotoxic stress. Hematological malignancies are characterized by genomic instability that is possibly related to underlying defects in DNA repair of genomic stability maintenance. We have investigated the ex... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does anthraquinonyl glycoside facilitate the standardization of graphene electrodes for the impedance detection of lectins? | [
"Construction of electrochemical impedance sensors by the self-assembly technique has become a promising strategy for the 'label-free' detection of protein-ligand interactions. However, previous impedance sensors are devoid of an inherent electrochemical signal, which limits the standardization of the sensors for p... | [
"Sanguisorba minor, as well as several other edible herbs and vegetables, has been used extensively in traditional medicine. The observed beneficial effects can be attributed at least in part to the direct modulation of several enzymatic activities by its polyphenolic constituents. The ethanol extract of Sanguisorb... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is perfusion CT a valuable diagnostic method for prostate cancer : a prospective study of 94 patients? | [
"The aim of this study is to assess the usefulness of perfusion computer tomography (pCT) in prostate cancer (PCa) diagnostics. 94 patients with biopsy-proven PCa were enrolled in the study. Dynamic pCT of the prostate gland was performed for 50 seconds after an intravenous injection of contrast medium. Blood flow ... | [
"The sensitivity of preoperative assessment of colorectal liver metastases (CRLM) ranges from 74 to 80%. Intraoperative ultrasound (IOUS) associated with contrast-enhanced intraoperative ultrasound (CE-IOUS) may be able to improve this. Thus, the aims of this study were to assess the value of IOUS and CE-IOUS for t... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does peritumoral interstitial fluid flow velocity predict survival in cervical carcinoma? | [
"High tumor interstitial fluid pressure (IFP) is associated with poor outcome in locally advanced carcinoma of the uterine cervix. We have recently developed a noninvasive assay of the IFP of tumors, and in this assay, the outward interstitial fluid flow velocity at the tumor surface (v0) is measured by Gd-DTPA-bas... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do workplace learning through peer groups in medical school clerkships? | [
"When medical students move from the classroom into clinical practice environments, their roles and learning challenges shift dramatically from a formal curricular approach to a workplace learning model. Continuity among peers during clinical clerkships may play an important role in this different mode of learning.... | [
"A staff-driven peer review process was developed and implemented to determine if it would improve the perception of the quality of nursing care delivered and unit performance."
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does [ Prevalence of anxiety disturb in patients with Tourette syndrome and tic disturb ]? | [
"Tourette syndrome (TS) is characterized by a wide phenotypic polymorphism and this heterogeneity is due partly to the association with several neuropsychiatry disorders. These comorbidities are showed in the 90% of TS cases. The aim of this transversal study is to analyze the presence and prevalence of different p... | [
"The inhibitory transmitter GABA has been suggested to play an important role in infantile autistic syndrome (IAS), and extensive investigations suggest that excitatory actions of GABA in neurological disorders are because of a persistent increase of [Cl(-) ](I) . To test the effects of the chloride co-transporte... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do native and denatured egg white protein IgE tests discriminate hen 's egg allergic from egg-tolerant children? | [
"Accurate diagnosis of egg allergy by IgE testing is challenged by a large number of atopic subjects sensitized, but clinically tolerant to eggs. In addition, discrimination between allergy to raw only, or raw and cooked egg allergy is important. In this study, we investigate the diagnostic performance of IgE tests... | [
"Cereals are among the major foods that account for food hypersensitivity reactions. Salt-soluble proteins appear to be the most important allergens contributing to the asthmatic response. In contrast, very limited information is available regarding cereal allergens responsible for allergic reactions after ingestio... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is delay of airway epithelial wound repair in COPD associated with airflow obstruction severity? | [
"Airway epithelium integrity is essential to maintain its role of mechanical and functional barrier. Recurrent epithelial injuries require a complex mechanism of repair to restore its integrity. In chronic obstructive pulmonary disease (COPD), an abnormal airway epithelial repair may participate in airway remodelin... | [
"Increased airway Na(+) absorption mediated by epithelial Na(+) channels (ENaC) is a characteristic abnormality in the pathogenesis of cystic fibrosis (CF) lung disease. However, inhalation therapy with the ENaC blocker amiloride did not have therapeutic benefits in patients with CF with established lung disease. W... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do aversive stimuli drive drug seeking in a state of low dopamine tone? | [
"Stressors negatively impact emotional state and drive drug seeking, in part, by modulating the activity of the mesolimbic dopamine system. Unfortunately, the rapid regulation of dopamine signaling by the aversive stimuli that cause drug seeking is not well characterized. In a series of experiments, we scrutinized ... | [
"Methylphenidate (MPH) is a commonly-used medication for the treatment of children with Attention-Deficit/Hyperactivity Disorders (ADHD). However, its prescription to adults with ADHD and narcolepsy raises the question of how the brain is impacted by MPH exposure during pregnancy. The goal of this study was to eluc... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do zero adjusted models with applications to analysing helminths count data? | [
"It is common in public health and epidemiology that the outcome of interest is counts of events occurrence. Analysing these data using classical linear models is mostly inappropriate, even after transformation of outcome variables due to overdispersion. Zero-adjusted mixture count models such as zero-inflated and ... | [
"A relation between the size of treatment efficacy and severity of the disease has been postulated and observed as linear for a few therapies. We have called this relation the effect model. Our objectives were to demonstrate that the relation is general and not necessarily linear. We extend the number of observed e... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does an aboveground pathogen inhibit belowground rhizobia and arbuscular mycorrhizal fungi in Phaseolus vulgaris? | [
"Induced aboveground plant defenses against pathogens can have negative effects on belowground microbial symbionts. While a considerable number of studies have utilized chemical elicitors to experimentally induce such defenses, there is surprisingly little evidence that actual aboveground pathogens affect root-asso... | [
"To find sustainable alternatives to the application of synthetic chemicals for oomycete pathogen suppression. Here, we present experiments on an Arabidopsis thaliana model system in which we studied the antagonistic properties of rhizobacterium Paenibacillus polymyxa strains towards the oomycete plant pathogens Ph... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does gender influence headache characteristics with increasing age in migraine patients? | [
"Migraine headache is one of the most common primary headache disorders and is three times more prevalent in women than in men, especially during the reproductive ages. The neurobiological basis of the female dominance has been partly established. The present study aimed to investigate the effect of gender on the h... | [
"Sleep disorders, nightmares and visual hallucinations have been reported in migraine patients, which may suggest the involvement of rapid eye movement (REM) sleep regulation in migraine. However, the relationship between migraine and REM sleep behaviour disorder (RBD) remains unclear. To investigate the clinical c... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are stress and inflammatory biomarkers and symptoms associated with bioimpedance measures? | [
"This large cross-sectional, multi-centre study evaluated the association of body composition measurements by a novel dual frequency bioimpedance device (BIA-ACC) with chronic stress/inflammation biomarkers and the presence of medically unexplained symptoms (MUS). Participants were adult Caucasians of both sexes an... | [
"To what extent do patient- and treatment-related factors explain the variation in morphokinetic parameters proposed as embryo viability markers?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does piericidin A aggravate Tau pathology in P301S transgenic mice? | [
"The P301S mutation in exon 10 of the tau gene causes a hereditary tauopathy. While mitochondrial complex I inhibition has been linked to sporadic tauopathies. Piericidin A is a prototypical member of the group of the piericidins, a class of biologically active natural complex I inhibitors, isolated from streptomyc... | [
"The nicotinamide-nucleotide adenylyltransferase protein Nmnat1 is a potent inhibitor of axonal degeneration in models of acute axonal injury. Hyperphosphorylation and aggregation of the microtubule-associated protein Tau are associated with neurodegeneration in Alzheimer's Disease and other disorders. Previous stu... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are cognitive-behavioral phenotypes of Williams syndrome associated with genetic variation in the GTF2I gene , in a healthy population? | [
"Individuals with Williams syndrome, a neurogenetic condition caused by deletion of a set of genes at chromosomal location 7q11.23, exhibit a remarkable suite of traits including hypersociality with high, nonselective friendliness and low social anxiety, expressive language relatively well-developed but under-devel... | [
"Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared. We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are long-term changes in body weight associated with changes in blood pressure levels? | [
"Hypertension and obesity are highly prevalent in Western societies. We investigated the associations of changes in body weight with changes in blood pressure and with incident hypertension, incident cardiovascular events, or incident normalization of blood pressure in patients who were hypertensive at baseline, ov... | [
"Body composition and obesity-related lifestyle factors are associated with increased risk for Alzheimer's disease (AD). Amyloid beta (Abeta) is a peptide integral in the pathogenesis of AD. Abeta has been shown to be related to body fat and exercise in younger adults; however, no study to date has examined the pos... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does vascular reconstruction play an important role in the treatment of pancreatic adenocarcinoma? | [
"Previous studies have proved the feasibility of performing a pancreaticoduodenectomy (Whipple operation) in patients with portal vein-superior mesenteric vein and hepatic artery invasion. We report our institutional experience with the use of a variety of vascular reconstructive methods during pancreatic resection... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is matrix metalloproteinase 10 associated with disease severity and mortality in patients with peripheral arterial disease? | [
"Peripheral arterial disease (PAD) is associated with poor prognosis in terms of cardiovascular (CV) morbidity and mortality. Matrix metalloproteinases (MMPs) contribute to vascular remodeling by degrading extracellular matrix components and play a role in atherosclerosis as demonstrated for MMP-10 (stromelysin-2).... | [
"Do platelets play any role in the development of endometriosis?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does selective renal blood perfusion induce renal tubules injury in a porcine model? | [
"Extracorporeal circulation is routinely used in thoracoabdominal aortic aneurysm repair to preserve blood perfusion. Despite this protective measure, acute and chronic kidney disorders can develop. Therefore, the aim of this study was to establish a new large-animal model to assess the efficacy of selective renal ... | [
"Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the protease-activated receptor 1. Parstatin was recently found to be cardioprotective against myocardial ischemia/reperfusion (IR) injury. In the present study, it was hypothesized that parstatin would protect the kidneys in acute renal... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does inhibition of urothelial P2X3 receptors prevent desensitization of purinergic detrusor contractions in the rat bladder? | [
"To evaluate whether P2X3 receptors (P2X3R) are expressed in the bladder urothelium and to determine their possible function in modulating purinergic detrusor contractions in the rat urinary bladder. The expression of urothelial receptors was determined using conventional immunohistochemistry in bladders from norma... | [
"Chronic stress exacerbates or causes relapse of symptoms such as abdominal pain and cramping in patients with irritable bowel syndrome. We investigated whether chronic stress increases plasma norepinephrine and sensitizes colon-specific dorsal root ganglion (DRG) neurons by increasing expression of nerve growth fa... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does high lifetime inbreeding depression counteract the reproductive assurance benefit of selfing in a mass-flowering shrub? | [
"Decreases in mate and/or pollinator availability would be expected to affect the selective pressure on plant mating systems. An increase in self-fertilization may evolve to compensate for the negative effects of pollination failure. However, the benefit of selfing in variable pollination environments depends on th... | [
"• Recent studies suggest that invasive plants compete reproductively with native plants by reducing the quantity or quality of pollinator visits. Although these studies have revealed ecological consequences of pollinator-mediated competition between invasive and native plants, the evolutionary outcomes of these in... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are genes associated with antibody-dependent cell activation overexpressed in renal biopsies from patients with antibody-mediated rejection? | [
"Antibody-mediated rejection (ABMR) is dependent on complement activating donor-specific anti-HLA antibodies (DSA). This is commonly detected by C4d deposition in allografts. However, recent data define a C4d negative ABMR phenotype suggesting a role for complement-independent DSA injury, antibody-dependent cellula... | [
"Macrophage infiltration and cytokine production are important in the pathogenesis of crescentic glomerulonephritis in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis. The aim of this study was to investigate whether urinary levels of chemokines, monocyte chemoattractant protein-1 (MCP-1) and fracta... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does measurement of refractive index by nanoparticle tracking analysis reveal heterogeneity in extracellular vesicles? | [
"Optical techniques are routinely used to size and count extracellular vesicles (EV). For comparison of data from different methods and laboratories, suitable calibrators are essential. A suitable calibrator must have a refractive index (RI) as close to that of EV as possible but the RI of EV is currently unknown. ... | [
"The use of acoustic forces to manipulate particles or cells at the microfluidic scale (i.e. acoustophoresis), enables non-contact, label-free separation based on intrinsic cell properties such as size, density and compressibility. Acoustophoresis holds great promise as a cell separation technique in several resear... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do nomograms incorporating serum C-reactive protein effectively predict mortality before and after surgical treatment of renal cell carcinoma? | [
"To incorporate C-reactive protein into nomograms estimating survival in patients with renal cell carcinoma. Patients undergoing surgery for renal cell carcinoma from 2005-2012 were studied retrospectively. Multivariable Cox proportional hazards regression and competing risks regression models including stage, grad... | [
"Postoperative renal impairment can increase postoperative mortality and morbidity. We sought to identify preoperative risk factors responsible for postoperative renal impairment in patients undergoing aortic surgery. This prospective study included 249 patients admitted for aortic surgery. Preoperative and postope... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do endogenous female sex hormones delay the development of renal dysfunction in apolipoprotein E-deficient mice? | [
"Hypercholesterolemia is a well-established risk factor for the development of kidney injury. Considering that female sex hormones may play a preventative role in both cardiovascular and renal diseases, the aim of the present study was to evaluate the effects of female sex hormones on hypercholesterolemia-induced r... | [
"Cigarette smoking is an independent risk factor for atherosclerosis. Nicotine, the addictive component of cigarettes, induces mast cell (MC) release and contributes to atherogenesis. The purpose of this study was to determine whether nicotine accelerates atherosclerosis through MC-mediated mechanisms and whether M... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is fractionation of electrograms caused by colocalized conduction block and connexin disorganization in the absence of fibrosis as AF becomes persistent in the goat model? | [
"Electrogram fractionation and atrial fibrosis are both thought to be pathophysiological hallmarks of evolving persistence of atrial fibrillation (AF), but recent studies in humans have shown that they do not colocalize. The interrelationship and relative roles of fractionation and fibrotic change in AF persistence... | [
"Ventricular tachyarrhythmia is the leading cause of sudden cardiac death, and scroll wave re-entry is known to underlie this condition. Class III antiarrhythmic drugs are commonly used worldwide to treat ventricular tachyarrhythmias; however, these drugs have a proarrhythmic adverse effect and can cause Torsade de... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does severe nutritional risk predict decreased long-term survival in geriatric patients undergoing pancreaticoduodenectomy for benign disease? | [
"Weight loss and malnutrition are poorly tolerated by geriatric patients, and pancreaticoduodenectomy (PD) can result in chronic malabsorption and weight loss. We sought to determine how preoperative severe nutritional risk (SNR), as defined by the American College of Surgeons National Surgical Quality Improvement ... | [
"Nursing home residents undergoing surgery have a higher rate of postoperative adverse outcomes than nonnursing home patients. This study seeks to determine what contribution nursing home status makes to theses occurrences, independent of comorbid conditions. Using the American College of Surgeons-National Surgical... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does peripherally administered oxytocin modulate latent inhibition in a manner consistent with antipsychotic drugs? | [
"Peripherally administered oxytocin (OT) has produced antipsychotic drug (APD)-like effects in animal tests that are predictive of APD efficacy. However, these effects have mainly been demonstrated using animal models of schizophrenia-like deficits in prepulse inhibition (PPI) of the startle reflex. Another schizop... | [
"Stress and glucocorticoid hormones, which are released into the circulation following stressful experiences, have been shown to contribute significantly to the manifestation of anxiety-like behaviors observed in many neuropsychiatric disorders. Brain-derived neurotrophic factor (BDNF) signaling through its recepto... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does generalizability of trial result to elderly Medicare patients with advanced solid tumors ( Alliance 70802 )? | [
"In the United States, patients who enroll in chemotherapy trials seldom reflect the attributes of the general population with cancer, as they are often younger, more functional, and have less comorbidity. We compared survival following three chemotherapy regimens according to the setting in which care was delivere... | [
"Effective adjuvant chemotherapy (Adj.C) for completely resected non-small cell lung cancer (NSCLC) was recently established. However, there may be some unresolved adverse effects, as have been observed in early stage populations or long-term survivors after other types of Adj.C. The substantial risk in such patien... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do a phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer? | [
"Diets high in cruciferous vegetables are associated with lower risk of incidence of prostate cancer, including aggressive forms of this disease. Human intervention studies with cruciferous vegetable-rich diets also demonstrate modulation of gene expression in important pathways in prostate cells. Sulforaphane is a... | [
"Prostate cancer is an important public health problem. It is an excellent candidate disease for chemoprevention because prostate cancer is typically slow growing and is usually diagnosed in elderly males. Pygeum africanum (Prunus africana or Rosaceae) is an African prune (plum) tree found in tropical Africa. An ex... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does beta-blocker Treatment Worsen Critical Limb Ischemia in Patients Receiving Endovascular Therapy? | [
"It has been reported that beta-blockers (BB) reduce cardiovascular events in patients with atherosclerotic disease. However, little is known about the efficacy of these drugs in patients with critical limb ischemia (CLI). We investigated whether beta-blocker therapy affects the clinical outcomes of CLI patients. B... | [
"The purpose of this study was to determine whether myeloid differentiation factor88-dependent Toll-Like Receptor-4 (TLR-4) signaling contributed to the inhibition of abdominal aortic aneurysm (AAA) by Tanshinone IIA (Tan IIA). Male Sprague-Dawley rats (n = 12 / group) were randomly distributed into three groups: T... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does electric stimulation at 448 kHz promote proliferation of human mesenchymal stem cells? | [
"Capacitive-resistive electric transfer (CRET) is a non invasive electrothermal therapy that applies electric currents within the 400 kHz - 450 kHz frequency range to the treatment of musculoskeletal lesions. Evidence exists that electric currents and electric or magnetic fields can influence proliferative and/or d... | [
"Due to their properties and characteristics human mesenchymal stem cells (MSCs) appear to have great therapeutic potential. Many different populations of MSCs have been described and to understand whether they have equivalent biological properties is a critical issue for their therapeutic application. We proposed ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is pre-surgical cortical activation to food pictures associated with weight loss following bariatric surgery? | [
"Recent research suggests that preintervention functional magnetic resonance imaging (fMRI) data may predict weight loss outcomes among patients who participate in a behavioral weight loss plan. No study has examined whether presurgical brain activation can predict outcomes following bariatric surgery. The aim of t... | [
"Cytidine-5'-diphosphocholine (citicoline) has a variety of cognitive enhancing, neuroprotective, and neuroregenerative properties. In cocaine-addicted individuals, citicoline has been shown to increase brain dopamine levels and reduce cravings. The effects of this compound on appetite, food cravings, and brain res... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
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Are atherogenic index of plasma and atherogenic coefficient increased in major depression and bipolar disorder , especially when comorbid with tobacco use disorder? | [
"There is a robust comorbidity between mood disorders and cardiovascular disorder (CVD). The atherogenic index of plasma (AIP) and the atherogenic coefficient (AC) are important atherogenic indexes. The aims of this study were to delineate whether AIP and AC are increased in mood disorders especially when comorbid ... | [
"The purpose of the present study was to examine the current prevalence of mood and anxiety disorders, and factors related to mood and anxiety disorders in patients with rheumatoid arthritis (RA). The study sample included 83 consecutive patients with RA who were admitted to a rheumatology outpatient clinic. Diagno... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do mid-regional proadrenomedullin levels predict recurrence of atrial fibrillation after catheter ablation? | [
"We evaluated the prognostic value of mid-regional proadrenomedullin (MR-proADM) in atrial fibrillation (AF) patients undergoing radiofrequency ablation. Plasma concentrations of MR-proADM were measured at baseline and after 12months in 87 AF patients in whom radiofrequency ablation was performed. The association b... | [
"The purpose of this study was to investigate the efficacy safety of the novel cryoballoon device (Arctic Front, Cryocath, Quebec, Canada). Antral pulmonary vein (PV) ablation with radiofrequency energy is widely used as a strategy for catheter ablation of paroxysmal atrial fibrillation (PAF). A novel double lumen ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does ellagic acid prevent monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3 inflammasome activation in rats? | [
"Pulmonary artery hypertension (PAH) is characterized by vascular remodeling, high pulmonary blood pressure, and right ventricular hypertrophy. Oxidative stress, inflammation and pulmonary artery remodeling are important components in PAH. Ellagic acid (EA) is a phenolic compound with anti-oxidative, anti-inflammat... | [
"Much evidence suggests that vascular remodelling in the lung plays a crucial role in the development of pulmonary fibrosis. Therefore, anti-angiogenesis therapy may be a promising treatment for pulmonary fibrosis. Recently, a new inhibitor called vasohibin has been discovered to operate as an intrinsic and highly ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
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} |
Is preeclampsia associated with lower production of vascular endothelial growth factor by peripheral blood mononuclear cells? | [
"Recent studies show that vascular endothelial growth factor (VEGF) downregulation is implicated in preeclampsia (PE) pathophysiology. This study assessed the relationship between PE and VEGF levels produced by peripheral blood mononuclear cells (PBMCs) and their serum levels. A cross-sectional design was performed... | [
"Does intrauterine biosynthesis of estrogen play an important role in early pregnancy by altering the function of uterine natural killer (uNK) cells?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
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} |
Do freezing of gait subtypes have different cognitive correlates in Parkinson 's disease? | [
"Freezing of gait (FOG) is a major concern for Parkinson's disease (PD) patients because it is a leading cause of falls and is associated with poor quality of life. The pathophysiology is unknown but it is hypothesized that it relates to cognitive abnormalities; particularly executive and visuospatial dysfunction. ... | [
"There is a gap in the systematic description and investigation of functional disability in corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). Additionally, the relations between disability, apraxia, cognitive and behavioural changes are not well understood in atypical parkinsonian syndromes. Fif... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does a tourniquet assisted cardiopulmonary resuscitation augment myocardial perfusion in a porcine model of cardiac arrest? | [
"During cardiopulmonary resuscitation (CPR), myocardial blood flow generated by chest compression rarely exceeds 35% of its normal level. Cardiac output generated by chest compression decreases gradually with the prolongation of cardiac arrest and resuscitation. Early studies have demonstrated that myocardial blood... | [
"Sodium nitroprusside-enhanced cardiopulmonary resuscitation consists of active compression-decompression, an impedance threshold device, abdominal binding, and large intravenous doses of sodium nitroprusside. We hypothesize that sodium nitroprusside-enhanced cardiopulmonary resuscitation will significantly increas... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does a common polymorphism in pre-miR-146a underlie Hirschsprung disease risk in Han Chinese? | [
"Hirschsprung disease (HSCR) is a rare multigenic congenital disorder characterized by the absence of the enteric ganglia. To date, single nucleotide polymorphisms (SNPs) in pre-miRNAs have been confirmed related with some diseases. Thus, we hypothesized that pre-miRNA polymorphisms might contribute to HSCR suscept... | [
"Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis receptor on human dendritic cells. We reasoned that if DC-SIGN interacts with M. tuberculosis, as well as with other pathogens, v... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do increased litter size and suckling intensity inhibit KiSS-1 mRNA expression in rat arcuate nucleus? | [
"The effect of litter size and suckling intensity on the expression of KiSS-1 mRNA in the arcuate nucleus (ARC) of rats were evaluated. Thirty two pregnant and four non-lactating ovariectomized (as control group) rats were used in this experiment. Lactating rats were allotted to eight equal groups. In three groups,... | [
"Gonadotropin-inhibitory hormone (GnIH)-3 is a neuropeptide that plays a major role in the regulation of reproduction and feeding in mammals. We measured endocrine and behavioural parameters of reproduction in sheep, and sexual behaviour in sheep, mice and cynomolgus monkeys. In addition, GnIH gene expression (in s... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do glaucoma and associated visual acuity and field loss significantly affect glaucoma-specific psychosocial functioning? | [
"To examine the impact of glaucoma and visual acuity (VA) and visual field (VF) losses on psychosocial functioning (PF). Cross-sectional study. We compared PF between 192 participants with bilateral glaucoma with VA or VF losses and 40 controls from a tertiary eye hospital clinic in Singapore. Glaucoma was defined ... | [
"To evaluate the hypothesis that increased neuropsychiatric distress and cognitive impairment are associated with lower perceived health status in essential tremor (ET). Many patients with ET experience nonmotor complications, including lower perceived health status and poor health-related quality of life, which ar... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does unilateral Hypothalamus Inactivation prevent PTZ Kindling Development through Hippocampal Orexin Receptor 1 Modulation? | [
"Epilepsy is a neural disorder in which abnormal plastic changes during short and long term periods lead to increased excitability of brain tissue. Kindling is an animal model of epileptogenesis which results in changes of synaptic plasticity due to repetitive electrical or chemical sub-convulsive stimulations of t... | [
"Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation - including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons. AdipoRs play a critical role in regulating glucose and fatty acid metabolism by initiating several... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is termination of Nociceptive Bahaviour at the End of Phase 2 of Formalin Test Attributable to Endogenous Inhibitory Mechanisms , but not by Opioid Receptors Activation? | [
"Formalin injection induces nociceptive bahaviour in phase I and II, with a quiescent phase between them. While active inhibitory mechanisms are proposed to be responsible for initiation of interphase, the exact mechanisms which lead to termination of nociceptive response in phase II are not clear yet. Phase II is ... | [
"Many studies show an effectiveness of hypnotic analgesia. It has been discussed whether the analgesic effect is mainly caused by the relaxation that is concomitant to hypnosis. This study was designed to evaluate the effects of hypnotic relaxation suggestion on different somatosensory detection and pain thresholds... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI? | [
"To improve the extent over which whole brain quantitative three-dimensional (3D) magnetic resonance spectroscopic imaging (MRSI) maps can be obtained and be used to explore brain metabolism in a population of healthy volunteers. Two short echo time (20 ms) acquisitions of 3D echo planar spectroscopic imaging at tw... | [
"To determine whether Dixon-based fat separation techniques can provide more robust removal of lipid signals from multiple-mouse magnetic resonance imaging (MRI)-acquired images than conventional frequency selective chemical saturation techniques. A two-point Dixon technique was implemented using a RARE-based pulse... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does vasopressin raise cardiac enzymes following cardiac surgery : a randomized double-blind clinical trial? | [
"The aim of this study was to investigate the relationship between intraoperative vasopressin infusion and postoperative cardiac enzymes. A prospective, double-blind, randomized, controlled study. A single tertiary cardiac center. One hundred consecutive patients undergoing cardiac surgery with or without cardiopul... | [
"Lornoxicam is a novel non-steroidal anti-inflammatory drug with marked analgesic property. It has been shown to have analgesic potency similar to morphine and meperidine. Laryngoscopy and tracheal intubation provoke major haemodynamic responses. Minimizing perioperative adverse events in elderly patients is of utm... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does converging evidence implicate the abnormal microRNA system in schizophrenia? | [
"Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation of brain development through microRNA (miRNA) systems. This study aims to (1) compare the overall frequency of 121 rare variants (RVs) in 59 genes ass... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do periodontal ligament mesenchymal stromal cells increase proliferation and glycosaminoglycans formation of temporomandibular joint derived fibrochondrocytes? | [
"Temporomandibular joint (TMJ) disorders are common disease in maxillofacial surgery. The aim of this study is to regenerate fibrocartilage with a mixture of TMJ fibrochondrocytes and periodontal ligament derived mesenchymal stem cells (PD-MSCs). Fibrochondrocytes and PD-MSC were cocultured (ratio 1 : 1) for 3 week... | [
"To characterize the molecular changes that occur in normal fibroblasts, adhesion fibroblasts, and mesothelial cells as a result of exposure to modified hyaluronic acid and carboxymethylcellulose (Seprafilm). University research laboratory. Human mesothelial and fibroblast cell culture. Multiplex reverse transcript... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is digital rectal examination in primary care important for early detection of prostate cancer : a retrospective cohort analysis study? | [
"Currently, there is no standardised screening for prostate cancer in Europe. Assessment of risk is opportunistically undertaken in consultation with the GP or urologist. Evaluation of the prostate gland consists of a prostate-specific antigen (PSA) serum level and a digital rectal examination (DRE) of the gland. D... | [
"To what extent are outcome measures in endometriosis-related quality of life studies influenced by the setting in which patient recruitment is performed?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does clinical trial demonstrate exercise following bariatric surgery improves insulin sensitivity? | [
"Roux-en-Y gastric bypass (RYGB) surgery causes profound weight loss and improves insulin sensitivity (S(I)) in obese patients. Regular exercise can also improve S(I) in obese individuals; however, it is unknown whether exercise and RYGB surgery-induced weight loss would additively improve S(I) and other cardiometa... | [
"The thiazolidinedione (TZD) drugs, including pioglitazone (Actos) and rosiglitazone (Avandia), are commonly prescribed in patients with type 2 diabetes mellitus (T2DM), largely due to their favorable effects on hyperglycemia, insulin sensitivity, and cardiometabolic profile. However, the data are sparse assessing ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do differential behavior patterns in cynomolgus monkey Macaca fascicularis in home cage in response to human gaze? | [
"Non-human primates, when encountering human beings, show wariness and alertness. These behaviors differ when there is direct human gaze vs. when human averts his gaze. We observed cynomolgus monkey in their home cage and studied their behaviors in response to human gaze. Four behaviors were analyzed: opening mouth... | [
"Complex behavioral traits such as coping strategies in response to stress are usually formed by genetic and environmental influences. By exploiting the phenotypic and genotypic differences between the Wistar Kyoto (WKY) and Fischer 344 (F344) inbred rat strains, we recently identified three X chromosome-linked qua... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are genes related to emphysema enriched for ubiquitination pathways? | [
"Increased small airway resistance and decreased lung elasticity contribute to the airflow limitation in chronic obstructive pulmonary disease (COPD). The lesion that corresponds to loss of lung elasticity is emphysema; the small airway obstruction is due to inflammatory narrowing and obliteration. Despite their co... | [
"Maternal diabetes is a well-known risk factor for birth defects, such as heart defects and neural tube defects. The causative molecular mechanisms in the developing embryo are currently unknown, and the pathogenesis of developmental abnormalities during diabetic pregnancy is not well understood. We hypothesized th... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does unravelling associations between unassigned mass spectrometry peak with frequent itemset mining techniques? | [
"Mass spectrometry-based proteomics experiments generate spectra that are rich in information. Often only a fraction of this information is used for peptide/protein identification, whereas a significant proportion of the peaks in a spectrum remain unexplained. In this paper we explore how a specific class of data m... | [
"Although microarray gene expression analysis has become popular, it remains difficult to interpret the biological changes caused by stimuli or variation of conditions. Clustering of genes and associating each group with biological functions are often used methods. However, such methods only detect partial changes ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does celecoxib induce epithelial-mesenchymal transition in epithelial ovarian cancer cells via regulating ZEB1 expression? | [
"The purpose of our study was to investigate the therapeutic potential of Celecoxib for epithelial ovarian cancer, especially on cellular morphological changes, proliferation invasion and epithelial-mesenchymal transition (EMT). The MTT and transwell assays were performed to evaluate the effect of Celecoxib on prol... | [
"Aberrant activation of MAPK has been implicated to play important roles in pathological processes of endometriosis. However, how MAPK are constitutively activated in endometriotic tissues remains largely unknown. microRNA are small noncoding RNA that regulate the stability or translational efficiency of target mRN... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is dACT1 involved in human placenta development by promoting Wnt signaling? | [
"The aim of this study was to evaluate the expression of DACT1 in human placenta tissue and the relationship between DACT1 and target genes of the Wnt signaling pathway. Real-time PCR and western blotting were used to detect the expression of DACT1 and the target genes of Wnt signaling pathway in human placenta tis... | [
"Argonaute2 (Ago2) plays a fundamental role in microRNA-mediated gene regulation through its intrinsic endonuclease activity. In this study we demonstrate the novel functions and molecular mechanisms by which nuclear Ago2 directly regulates HSP (heat shock protein) 60 expression and stem cell self-renewal. HSP60 is... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do ileal neuroendocrine tumors show elevated activation of mammalian target of rapamycin complex? | [
"Neuroendocrine tumors (NETs) of the ileum are sporadic tumors derived from submucosal gastrointestinal stem cells. They often show clinical symptoms only after hepatic metastasation when curative therapy is limited or impossible. In this study, we analyzed the expression of the candidate genes mammalian target of ... | [
"A dozen clinical trials examining a combination of temsirolimus and cetuximab in treating metastatic colon cancer are currently underway. We investigated the role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in the synergism between temsirolimus and cetuximab in colon cancer. Five colon cancer cell lin... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does core needle biopsy of breast cancer tumors increase distant metastases in a mouse model? | [
"Incisional biopsies, including the diagnostic core needle biopsy (CNB), routinely performed before surgical excision of breast cancer tumors are hypothesized to increase the risk of metastatic disease. In this study, we experimentally determined whether CNB of breast cancer tumors results in increased distant meta... | [
"The use of surgery for metastatic lung cancer has been established recently and the indications have been extended to multiple and bilateral lung metastases. However, in some patients, secondary lung metastasis appears soon after the first pulmonary surgery, making curative treatment very difficult. Postoperative ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is hAP1 gene expression associated with radiosensitivity in breast cancer cells? | [
"The purpose of this study was to investigate the relationship between huntingtin-associated protein1 (HAP1) gene and radiation therapy of breast cancer cells. HAP1 gene was transfected into breast cancer MCF-7 cells, which was confirmed by quantitative reverse transcription-polymerase chain reaction analysis (qRT-... | [
"The NIMA-related kinase 2 (NEK2) is a serine/threonine kinase that is involved in regulation of centrosome duplication and spindle assembly during mitosis. Dysregulation of these processes causes chromosome instability and aneuploidy, which are hallmark changes of many solid tumors. However, whether aberrant expre... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does patient-conducted anodal transcranial direct current stimulation of the motor cortex alleviate pain in trigeminal neuralgia? | [
"Transcranial direct current stimulation (tDCS) of the primary motor cortex has been shown to modulate pain and trigeminal nociceptive processing. Ten patients with classical trigeminal neuralgia (TN) were stimulated daily for 20 minutes over two weeks using anodal (1 mA) or sham tDCS over the primary motor cortex ... | [
"Severe stenosis of the internal carotid artery (ICA) has been associated with impaired cognition in patients, but its effect on rapid-onset cortical plasticity is not known. Carotid endarterectomy (CEA) in patients with severe ICA stenosis reduces stroke risk, but the impact on cognition or physiology of the respe... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does targeting high mobility group box protein 1 ameliorate testicular inflammation in experimental autoimmune orchitis? | [
"Does high mobility group box protein 1 (HMGB1) regulate inflammatory reactions in a rat model of experimental autoimmune orchitis (EAO)?"
] | [
"Autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS) affect a relatively large portion of the population, leading to severe disability if left untreated. Even though pharmaceutics targeting the immune system have revolutionised the therapy of these diseases, there is still a need for n... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are reclassification rates higher among African American men than Caucasians on active surveillance? | [
"To evaluate the risk of reclassification on serial biopsy for Caucasian and African American (AA) men with very low-risk (VLR) prostate cancer enrolled in a large prospective active surveillance (AS) registry. The Johns Hopkins AS registry is a prospective observational study that has enrolled 982 men since 1994. ... | [
"To assess the differences among racial and ethnic groups in their willingness to participate in medical infertility research. We further explored these differences within racial and ethnic subcategories to gain a broader understanding of minority patients' willingness to participate in infertility research. Cross-... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does pulmonary rehabilitation during induction chemoradiotherapy for lung cancer improve pulmonary function? | [
"Chemoradiotherapy for non-small cell lung cancer can impair pulmonary function, particularly when it is followed by surgery. This study aimed to document the changes in respiratory function as a result of a perioperative intensive pulmonary rehabilitation program in patients with non-small cell lung cancer who und... | [
"Thoracic and cardiac irradiation increases the risk of pulmonary and cardiovascular disease. In addition, radiation, often in combination with chemotherapy, can cause treatment-related pneumonitis. Previously, we showed that the common marker for cardiac damage, troponin T, was not elevated by chemoradiation [Lung... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is chronic central serous chorioretinopathy associated with genetic variants implicated in age-related macular degeneration? | [
"In this study, single nucleotide polymorphisms (SNPs) at 19 loci, previously associated with age-related macular degeneration (AMD), were systematically tested for association in patients with chronic central serous chorioretinopathy (cCSC). In addition, we evaluated the effect of detailed phenotyping on these gen... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do genetic variations of IL17F and IL23A show associations with Behçet 's disease and Vogt-Koyanagi-Harada syndrome? | [
"To investigate the associations of IL17A, IL17F, IL23A, and IL23R copy number variants (CNVs) with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) and the possible mechanisms involved. Two-stage case-control and functional studies. A total of 1159 VKH patients, 1036 BD patients, and 2050 controls wer... | [
"To determine the association between HLA class II alleles and the probability of developing cancer in patients with autoimmune rheumatic diseases. MATERIAL AND METHODS; A matched case control study was conducted in which patients with autoimmune rheumatic disease who later developed malignancy (solid or lymphoprol... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do [ Recovery of maxillary tooth sensibility after Le Fort I osteotomy ]? | [
"Upper alveolar nerves, when injured during Le Fort I osteotomies, alter maxillary tooth sensitivity. We had for aim to analyze post-operative maxillary tooth sensitivity recovery. We conducted a prospective study in a series of patients having undergone Le Fort I osteotomy, with, or without mandibular osteotomy or... | [
"Mandibular displacement is a common complication of condylar fracture. In the mandibular displacement due to condylar fracture, it is difficult to restore both esthetics and function without using orthognathic surgery. This clinical report described a full mouth rehabilitation in the patient with bilateral condyla... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does echogenicity of medium-to-large carotid plaques predict future vascular events? | [
"Although the echolucent plaque in carotid stenosis is associated with future ischemic stroke, the predictive value of echogenicity in small and medium size carotid plaques on vascular events has not been thoroughly examined. Thus, we prospectively tested the hypothesis that plaque echogenicity of carotid atheroma ... | [
"Retinal artery occlusion (RAO) is caused by arterio-arterial or cardiovascular emboli in about 50% of all cases, but the role of non-embolic causes remains unclear. We studied 27 patients with amaurosis fugax (AFX), branch retinal artery occlusion (BRAO), central retinal artery occlusion (CRAO) and anterior ischae... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is sTin2 VNTR polymorphism associated with comorbid tobacco use and mood disorders? | [
"There is a significant comorbidity between mood disorders and tobacco use disorder (TUD), which may be related to both genetic and environmental factors. Gene variants of the 5-HT transporter, such as STin2 VNTR (a variable number of tandem repeats in the functional serotonin transporter intron 2) may be associate... | [
"Is there a relationship between the genetic risk for polycystic ovary syndrome (PCOS) and genetic variants that influence timing of menopause?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do mesalazine and thymoquinone attenuate intestinal tumour development in Msh2 ( loxP/loxP ) Villin-Cre mice? | [
"Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine, commonly used for the treatment of UC, reduces MSI in vitro. Here, we tested natural compounds for such activity and applied mesalazine and thymoquinone in a Ms... | [
"Raf is one of the downstream effectors of Ras GTPases, and plays a key role in regulating cell proliferation and differentiation through the activation of MAPK. We have previously demonstrated that temporal induction of Raf in the epidermis of K14-Raf:ER transgenic mice results in epidermal hyperplasia resembling ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does infusion of human embryonic kidney cell line conditioned medium reverse kainic acid induced hippocampal damage in mice? | [
"Hippocampal neurodegeneration is one of the hallmarks in neurological and neurodegenerative diseases such as temporal lobe epilepsy and Alzheimer disease. Human embryonic kidney (HEK) cells are a mixed population of cells, including neurons, and their conditioned medium is enriched with erythropoietin (EPO). Becau... | [
"Whole-brain irradiation (WBI) therapy produces learning and memory deficits in patients with brain tumours. Although the pathological cascade of cognitive deficits remains unknown, it may involve reduced neurogenesis within the hippocampus. Baicalein is a flavonoid derived from the roots of Huangqin, Scutellaria b... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is low transferrin saturation associated with impaired fasting glucose and insulin resistance in the South Korean adults : the 2010 Korean National Health and Nutrition Examination Survey? | [
"The associations of transferrin saturation with diabetes have not been well evaluated and conflicting results have been reported. The purpose of this study is to examine the association of iron indices (serum ferritin and transferrin saturation) with risk of impaired fasting glucose and insulin resistance. We cond... | [
"Vitamin D insufficiency is known to be related to cardiometabolic disorders; however, the associations among serum 25-hydroxyvitamin D (25(OH)D) concentration and metabolic syndrome and cardiometabolic risk factors in children and adolescents have not yet been clearly delineated. For this reason, we investigated t... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does maternal nutrition induce gene expression changes in fetal muscle and adipose tissues in sheep? | [
"Maternal nutrition during different stages of pregnancy can induce significant changes in the structure, physiology, and metabolism of the offspring. These changes could have important implications on food animal production especially if these perturbations impact muscle and adipose tissue development. Here, we ev... | [
"Middle age obesity is recognized as a risk factor for Alzheimer's disease (AD) although a mechanistic linkage remains unclear. Based upon the fact that obese adipose tissue and AD brains are both areas of proinflammatory change, a possible common event is chronic inflammation. Since an autosomal dominant form of A... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is premature ejaculation associated with glycemic control in Type 1 diabetes? | [
"Premature ejaculation (PE) is the most common male sexual dysfunction. Its prevalence in Type 1 diabetes is unknown. The aim of this study was to assess the prevalence of PE in Type 1 diabetes and the influence of glycemic control on ejaculatory function. One hundred Type 1 diabetic male patients (age < 40 years) ... | [
"Is there an association between prolactin and markers of metabolic risk in polycystic ovary syndrome (PCOS)?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is myocardial scar characteristics based on cardiac magnetic resonance imaging associated with ventricular tachyarrhythmia in patients with ischemic cardiomyopathy? | [
"We hypothesized that myocardial scar characterization using cardiac magnetic resonance imaging (CMR) may be associated with the occurrence of ventricular tachyarrhythmia (VT), appropriate implantable cardioverter-defibrillator (ICD) therapy and mortality. Since a minority of patients with prophylactic ICD implanta... | [
"Cardiac Resynchronization Therapy (CRT) is indicated for the treatment of advanced heart failure with severe systolic dysfunction and intraventricular conduction delay. Patient selection for this technology is vital, though it remains unclear which patients benefit most from CRT. We tested the hypothesis that pati... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does institutional patient-specific IMRT QA predict unacceptable plan delivery? | [
"To determine whether in-house patient-specific intensity modulated radiation therapy quality assurance (IMRT QA) results predict Imaging and Radiation Oncology Core (IROC)-Houston phantom results. IROC Houston's IMRT head and neck phantoms have been irradiated by numerous institutions as part of clinical trial cre... | [
"Image-guided dose-escalated radiotherapy is the standard of care for the treatment of prostate cancer. Although many published methods are available that account for prostate motion during delivery, evidence demonstrating that the planned dose is actually delivered on a daily basis is lacking. We report our initia... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is depression a consistent syndrome : An investigation of unique symptom patterns in the STAR*D study? | [
"The DSM-5 encompasses a wide range of symptoms for Major Depressive Disorder (MDD). Symptoms are commonly added up to sum-scores, and thresholds differentiate between healthy and depressed individuals. The underlying assumption is that all patients diagnosed with MDD have a similar condition, and that sum-scores a... | [
"To compare the lifetime personality dysfunction of geriatric patients having late and early onset of major depression. Group comparisons. Inpatient geriatric psychiatry unit and hospital-based geriatric psychiatry outpatient clinic. Volunteer sample of recovered elderly depressives with history of early onset of m... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does canals of Hering loss relate to the progression of the histological stages of primary biliary cirrhosis? | [
"The canals of Hering (CoH), which are the most peripherally located bile drainage pathway, are considered a niche of hepatic progenitor cells. Recently, CoH loss has been described as an early feature of primary biliary cirrhosis (PBC). We investigated the correlation between CoH loss and the histopathological var... | [
"Do platelets play any role in the development of endometriosis?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does transcutaneous vagus nerve stimulation modulate tinnitus-related beta- and gamma-band activity? | [
"The ability of a treatment method to interfere with tinnitus-related neural activity patterns, such as cortical gamma rhythms, has been suggested to indicate its potential in relieving tinnitus. Therapeutic modulation of gamma-band oscillations with vagus nerve stimulation has been recently reported in epileptic p... | [
"While motor effects of dopaminergic medication and subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients are well explored, their effects on sensory processing are less well understood. Here, we studied the impact of levodopa and STN-DBS on auditory processing. Rhythmic auditory... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does lysophosphatidylserine have Bilateral Effects on Macrophages in the Pathogenesis of Atherosclerosis? | [
"Lysophospholipids, particularly sphingosine 1-phosphate and lysophosphatidic acid, are known to be involved in the pathogenesis of atherosclerosis; however, the role of lysophosphatidylserine (LysoPS) in the onset of atherosclerotic diseases remains uncertain. We investigated the effects of LysoPS on the uptake of... | [
"The purpose of this study was to determine whether myeloid differentiation factor88-dependent Toll-Like Receptor-4 (TLR-4) signaling contributed to the inhibition of abdominal aortic aneurysm (AAA) by Tanshinone IIA (Tan IIA). Male Sprague-Dawley rats (n = 12 / group) were randomly distributed into three groups: T... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does early experience with a new three-dimensional annuloplasty ring for the treatment of functional tricuspid regurgitation? | [
"Various techniques and devices have been proposed for tricuspid valve (TV) repair in patients with tricuspid regurgitation (TR). However, residual or recurrent TR is not uncommon occurring in 20% to 30% of patients. This study reports first experiences with a new three-dimensional annuloplasty ring. We retrospecti... | [
"Long-term survival after atrioventricular septal defect repair is excellent; however, postoperative left atrioventricular valve regurgitation affects morbidity and quality of life. Left atrioventricular valve regurgitation is the most common reason for reoperation after repair and it is critical that clinicians re... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is human cytomegalovirus infection associated with essential hypertension in Kazakh and Han Chinese populations? | [
"We aimed to study the association between cytomegalovirus (CMV) infection and hypertension in Kazakh and Han populations from Xinjiang Province, China. We analyzed data on 800 Kazakhs (467 hypertension patients and 333 healthy control participants) and 800 Hans (482 hypertension patients and 318 healthy control pa... | [
"Is there any effect of genetic polymorphisms in adiposity-related genes on the timing of menarche and menopause and the total duration of menstruation among Korean women?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is gut microbiome composition associated with temperament during early childhood? | [
"Understanding the dynamics of the gut-brain axis has clinical implications for physical and mental health conditions, including obesity and anxiety. As such disorders have early life antecedents, it is of value to determine if associations between the gut microbiome and behavior are present in early life in humans... | [
"Is there any effect of genetic polymorphisms in adiposity-related genes on the timing of menarche and menopause and the total duration of menstruation among Korean women?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is siglec-10 associated with survival and natural killer cell dysfunction in hepatocellular carcinoma? | [
"The interaction between Siglec-10 and its ligand, CD24, selectively represses tissue damage-caused immune responses. However, the nature of Siglec-10 and CD24 in human hepatocellular carcinoma (HCC) is still poorly defined. Hereon, the expression, function, and regulation of CD24 and Siglec-10 in HCC were investig... | [
"The role of polymorphonuclear granulocyte (PMN) infiltration in tumor remains unclear in esophageal cancer (EC). We conducted a retrospective study on consecutive patients with primary squamous EC. The potential roles of PMN infiltration into tumor nests were assessed by immunohistochemistry. The interactions of P... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does alpha 7 nicotinic acetylcholine receptor agonist GTS-21 mitigate isoflurane-induced cognitive impairment in aged rats? | [
"Postoperative cognitive dysfunction is increasingly recognized as an important clinical syndrome. Inhalation anesthetics are commonly used during surgery, and it has been proposed that inhalation anesthetics impair cognitive function. However, there are few clinical interventions and treatments available to preven... | [
"Panax ginseng root is used in traditional oriental medicine for human health. Its main active components such as saponins and polysaccharides have been widely evaluated for treating diseases, but secondary active components such as oligosaccharides have been rarely studied. This study aimed to assess the impact of... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does honokiol affect melanoma cell growth by targeting the AMP-activated protein kinase signaling pathway? | [
"Malignant melanoma is an aggressive form of skin cancer with limited effective therapeutic options. Melanoma research concentrates on maximizing the effect on cancer cells with minimal toxicity to normal cells. AMP-activated protein kinase (AMPK) is an important regulator of cellular energy homeostasis and has bee... | [
"Decreased levels of phosphatase and tensin homologue (PTEN) are associated with hepatocellular carcinoma (HCC) pathogenesis and poor prognosis in hepatitis C virus (HCV)-infected HCC patients. The molecular processes governing the reduction in PTEN and outcome of PTEN dysfunction in hepatocytes are poorly understo... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do dexamethasone intravitreal implant as adjunct therapy for patients with wet age-related macular degeneration with incomplete response to ranibizumab? | [
"To evaluate the visual and anatomical outcomes of dexamethasone intravitreal implant (DXI; 700 μg, Ozurdex; Allergan, Irvine, California, USA) as adjunctive therapy for patients with refractory wet age-related macular degeneration (AMD). Retrospective review of the medical records of seven patients (seven eyes) wh... | [
"The purpose of this study is to report a case of diabetic macular edema that resolved after systemic bevacizumab. This is an observational case report of a patient with diabetic macular edema. After initiation of systemic bevacizumab for a central nervous system glioblastoma, the diabetic macular edema resolved."
... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is shorter time to target temperature associated with poor neurologic outcome in post-arrest patients treated with targeted temperature management? | [
"Time to achieve target temperature varies substantially for patients who undergo targeted temperature management (TTM) after cardiac arrest. The association between arrival at target temperature and neurologic outcome is poorly understood. We hypothesized that shorter time from initiation of cooling to target temp... | [
"Intravenous (IV) infusion of ice cold saline is an effective method to initiate induction of mild therapeutic hypothermia (MTH) following resuscitation from out-of-hospital cardiac arrest (OOHCA). Intraosseous (IO) infusion of cold saline may be an alternative method to induce MTH. The goal of this study was to de... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do lipopolysaccharide and cytokines inhibit rat cardiomyocyte contractility in vitro? | [
"Sepsis-induced cardiomyopathy (SIC) is thought to be the result of detrimental effects of inflammatory mediators on the cardiac muscle. Here we studied the effects of prolonged (24 ± 4 h) exposure of adult rat ventricular myocytes (ARVM) to bacterial lipopolysaccharide (LPS) and inflammatory cytokines tumor necros... | [
"The endocardial endothelium that lines the inner cavity of the heart is distinct from the microvascular endothelial cells and modulates cardiac muscle performance in a manner similar to the vascular endothelial modulation of vascular structure and vasomotor tone. Although the modulatory effects of endocardial endo... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does wogonin modulate hydroperoxide-induced apoptosis via PI3K/Akt pathway in retinal pigment epithelium cells? | [
"Oxidative stress causes the defects of retinal pigment epithelial (RPE) cells that contribute to age-related macular degeneration (AMD). This study was conducted to determine whether wogonin could prevent H2O2-induced oxidative stress in RPE cells. A RPE cell line, ARPE-19, was obtained for the cell model. ARPE-19... | [
"The neuroinflammation induced by amyloid-beta peptide (Aβ) is one of the key events in Alzheimer's disease (AD) progress in which microglia are the main cells involved. Berberine, one of the major constituents of Chinese herb Rhizoma coptidis, is known for its anti-inflammatory, anti-oxidative and anti-microbial a... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do trends in outpatient MRI seem to reflect recent reimbursement cuts? | [
"To determine whether recent reimbursement cuts have resulted in a shift of outpatient MRI from private offices to hospital outpatient departments (HOPDs); and to study office MRI utilization trends among radiologists and other specialists. The Medicare Part B Physician/Supplier Procedure Summary Master Files were ... | [
"CT colonography (CTC) has been fully validated as an accurate screening test for colorectal carcinoma and is being disseminated globally. There is an abundance of new literature addressing the prior concerns of the U.S. Preventive Services Task Force and the Centers for Medicare & Medicaid Services. Specific areas... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is acute kidney injury independently associated with higher mortality after cardiac surgery? | [
"To investigate the incidence of acute kidney injury after cardiac surgery and its association with mortality in a patient population receiving ibuprofen and gentamicin perioperatively. Retrospective study with Cox regression analysis to control for possible preoperative, intraoperative and postoperative confounder... | [
"Women have been found to have greater mortality from coronary artery bypass grafting than men. Uncertainty exists regarding the causes of the differences in outcomes between men and women after coronary artery bypass grafting. From a database of 2,569 patients having coronary bypass grafting we have determined fac... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is the level of RECQL1 expression a prognostic factor for epithelial ovarian cancer? | [
"The human RECQ DNA helicase family is involved in genomic stability. Gene mutations of RECQL2, RECQL3, and RECQL4 are associated with genetic disorders and induce early aging and carcinogenesis. Although previous studies have reported that the level of RECQL1 expression is correlated with the prognosis of some of ... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do [ Clinical significance of continuous thrombocytopenia in predicting sepsis after severe burn ]? | [
"To explore the relationship between continuous thrombocytopenia and sepsis in patients with severe burns. Clinical data of 148 severely burned patients admitted to our,two burn centers from January 2007 to December 2011 and conforming to the study criteria were retrospectively analyzed. All patients were divided i... | [
"To identify the independent variables associated with death within 4 days after the first sepsis-induced organ dysfunction. In this prospective observational study, severe sepsis and septic shock patients were classified into 3 groups: Group 1, survivors; Group 2, late non-survivors; and Group 3, early non-survivo... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
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