query stringlengths 17 395 | pos list | neg list | task stringclasses 1
value | instruction dict |
|---|---|---|---|---|
Are plasma coenzyme Q10 reference intervals , but not redox status , affected by gender and race in self-reported healthy adults? | [
"Abnormal concentrations of coenzyme Q(10) have been reported in many patient groups, including certain cardiovascular, neurological, hematological, neoplastic, renal, and metabolic diseases. However, controls in these studies are often limited in number, poorly screened, and inadequately evaluated statistically. T... | [
"Is intake of fatty acids related to semen quality among young men?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does p16 ( INK4a ) induce differentiation and apoptosis in erythroid lineage cells? | [
"Hematopoiesis is regulated by proliferation, differentiation, and death. p16(INK4a) has been reported to regulate apoptosis and differentiation of diverse cells, as well as arresting the cell cycle at G1 phase. The aim of this study is to explore the properties of p16 in apoptosis and differentiation of erythroid ... | [
"Signaling pathways underlying BV8-mediated oncogenesis remain unknown. BV8-STAT3 forms a feed-forward loop in both normal and malignant myeloid cells and promotes tumor growth."
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does endothelin-receptor blockade mitigate the adverse effect of preretrieval warm ischemia on posttransplantation renal function in rats? | [
"Ischemia-reperfusion injury has been established as a nonimmunologic risk factor for the development of chronic graft nephropathy after renal transplantation. This objective of this study was to determine if oral administration of an endothelin-1 receptor (ET-R) antagonist over a 2-month period after renal transpl... | [
"Salusins are multifunctional endogenous bioactive peptides simultaneously biosynthesized from their precursor prosalusin. Salusin-β stimulates proliferation of vascular smooth muscle cells and fibroblasts and regulates myocardial growth and hypertrophy. Salusin-β has potent hypotensive, bradycardic and proatherosc... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is effect-site concentration of propofol for recovery of consciousness virtually independent of fentanyl effect-site concentration? | [
"Fentanyl reduces the amount of propofol necessary to prevent responses to surgical stimuli. However, opioids have relatively little effect on consciousness. We, therefore, tested the hypothesis that fentanyl minimally alters the effect-site concentration of propofol associated with awakening. Fifty women having gy... | [
"The aim of the study was to compare the potency of two different propofol formulations: proprietary and generic propofol using the bispectral index (BIS) monitoring. Forty female patients undergoing breast surgery received propofol 3 mg x kg(-1) followed by propofol infusion adjusted to maintain a 40% BIS value, s... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do alpha-2 adrenoreceptors probably mediate the immobility produced by inhaled anesthetics? | [
"Agonism of alpha-adrenoreceptors has a powerful anesthetic result mediated, in part, by effects on the spinal cord. Alpha-adrenoreceptor agonists (e.g., dexmedetomidine) can decrease the minimum alveolar anesthetic concentration (MAC) of inhaled anesthetics (e.g., halothane) to zero, with an apparently additive in... | [
"There is both clinical and experimental evidence to support the application of corticosterone in the management of inflammation and pain. Corticosterone has been used to treat painful inflammatory diseases and can produce antinociceptive effects. Epinephrine is synthesized from norepinephrine by the enzyme phenyle... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are resistive-heating and forced-air warming comparably effective? | [
"Serious adverse outcomes from perioperative hypothermia are well documented. Consequently, intraoperative warming has become routine. We thus evaluated the efficacy of a novel, nondisposable carbon-fiber resistive-heating system. Twenty-four patients undergoing open abdominal surgery lasting approximately 4 h were... | [
"The purpose of this study was to evaluate the efficacy of cloth stoma covers (bibs) to compensate for breathing unconditioned air after laryngectomy and loss of heat-moisture-exchange (HME) functions of the upper airways, which, to the best of our knowledge, has never been reported. In addition, we compared the ef... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are advanced glycation end-products pentosidine and N epsilon-carboxymethyllysine elevated in serum of patients with osteoporosis? | [
"To investigate serum levels of the advanced glycation end-products (AGEs) pentosidine and N epsilon-carboxymethyllysine (CML) in patients classified into different osteoporosis subgroups according to histomorphometric data. Serum samples were obtained from 116 osteoporotic patients (34 men, 82 women) classified by... | [
"Diabetic retinopathy is the result of increased oxidative and nitrosative stress induced by chronic hyperglycaemia, and affects the vasculature and the neuroglia. Erythropoietin is a neuroprotective and an endothelial survival factor. We assessed the effect of suberythropoietic epoetin delta doses on variables of ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is oxygen dependency of the adrenergic Na/H exchange in rainbow trout erythrocytes diminished by a hydroxyl radical scavenger? | [
"Potassium transport via the potassium chloride cotransporter in rainbow trout erythrocytes is increased by high oxygen tension. It appears that the effect of oxygen is mediated by reactive oxygen species, especially hydroxyl radicals. In contrast, the activity of adrenergically stimulated sodium proton exchange de... | [
"Ethanol impairs the mitochondrial transport of reduced glutathione (GSH), resulting in lower mitochondrial GSH (mGSH) levels. Our purpose was to evaluate the role of acetaldehyde on the regulation of mGSH in HepG2 cells. mGSH levels and transport, mitochondrial membrane microviscosity, and lipid composition were d... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does acute administration of conjugated equine oestrogen improve exercise-induced myocardial ischaemia in men with coronary artery disease? | [
"The parenteral administration of oestradiol acutely protects against exercise-induced myocardial ischaemia in women, but whether this effect is sex-specific is not known. The effects of acutely administered conjugated equine oestrogen on exercise-induced myocardial ischaemia in men with established coronary heart ... | [
"Elevated troponin I in the absence of angiographically visible coronary lesions is seen in up to 10-15% of those undergoing angiography for suspected coronary artery disease. This study aims to elucidate the etiology of elevated cardiac troponin I in patients with normal coronary arteries on angiography. We identi... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is an Ile93Met substitution in the UCH-L1 gene a disease-causing mutation for idiopathic Parkinson 's disease? | [
"To ascertain whether a coding mutation (Ile93Met) in ubiquitin carboxy-terminal hydrolase (UCH-L1) gene plays a role in idiopathic Parkinson's disease (IPD). Polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP) was used to distinguish the wild-type (two DNA fragments of 34 and 126 bp... | [
"The current obesity epidemic is attributed to complex interactions between genetic and environmental factors. However, a limited number of cases, especially those with early-onset severe obesity, are linked to single gene defects. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dys... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does mutilation anxiety differ among females with fibromyalgia and functional dyspepsia and population controls? | [
"Studies using self-report rating scales suggest a considerable overlap regarding symptom complaints in patients with fibromyalgia (FM) and functional dyspepsia (FD), while clinical assessments point to important psychological differences. To test the hypothesis that measurement of psychological state by means of c... | [
"Prior studies have addressed sexual abuse and sexual function in adult women. No studies have focused on the effect of adolescence rape on sexual functioning. To investigate the effect of rape on sexual problems and on pelvic floor problems, as well as the mediating role of pelvic floor problems on sexual problems... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does intramuscular alefacept improve health-related quality of life in patients with chronic plaque psoriasis? | [
"Psoriasis profoundly affects patient quality of life (QOL). Amevive (alefacept), a novel and selective biologic agent, was clinically effective and significantly improved QOL in a phase 2 study. The present placebo-controlled, randomized phase 3 study examined the effects of a 12-week course of intramuscular alefa... | [
"Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease. Since current treatments are unsatisfactory for many patients, there is a high need for effective drugs for this debilitating disease. Recent pathogenic insights suggest inflammasome activation and IL-1β production are important in HS. Colchici... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does the New York University nerve sparing algorithm decrease the rate of positive surgical margins following radical retropubic prostatectomy? | [
"We developed an algorithm that prospectively defines when to excise the neurovascular bundles during radical retropubic prostatectomy with the goal of maximizing the performance of nerve sparing procedures while minimizing positive surgical margins. From January 1 to December 31, 2000 a single surgeon performed 27... | [
"Laparoscopic or robot assisted laparoscopic radical prostatectomy is often performed via a transperitoneal approach for prostate cancer, in contrast to open retropubic radical prostatectomy. Theoretically transgressing the peritoneum may introduce small bowel loops into the pelvis, increasing the risk of small bow... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is percent of prostate needle biopsy cores with cancer significant independent predictor of prostate specific antigen recurrence following radical prostatectomy : results from SEARCH database? | [
"Recent studies have suggested that the percent of positive cores in the prostate needle biopsy is a significant predictor of outcome among men undergoing radical prostatectomy or radiation therapy for prostate cancer. We evaluate whether either percent of cores with cancer or percent of cores positive from the mos... | [
"Active surveillance (AS) is an expectant management strategy for prostate cancer (PCa). The impact of obesity on progression is not well characterized in this population. To determine if obesity is associated with progression in men on AS for low-risk PCa. Men undergoing AS for low-risk PCa (no Gleason pattern ≥4,... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Have the increased utilisation of dopamine agonists and the introduction of COMT inhibitors reduced levodopa consumption -- a nation-wide perspective in Sweden? | [
"To study the impact of the new pharmacological treatment strategies in Parkinson's disease by analysis of the sales of dopaminergic drugs in Sweden 1990-2001. Invoice statistics and statistics on prescription sales of dopaminergic drugs 1990-2001 were obtained from the 906 public pharmacies and the 89 hospital pha... | [
"Levodopa induced dyskinesias (LID) are a common problem which ultimately limit the effective treatment of patients with Parkinson's disease (PD). There is accumulating evidence that LID develop due to abnormal synaptic plasticity, which is in turn influenced by the release of brain derived neurotrophic factor (BDN... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does postoperative enteral stimulation by gut feeding improve outcomes in severe acute pancreatitis? | [
"We assessed the clinical effectiveness of postoperative enteral stimulation by gut feeding in patients with severe acute pancreatitis (SAP). Medical records of 63 patients who were operated on within the past 4 y due to deterioration of SAP were included in this retrospective study. Patients were stratified in gut... | [
"To assess the need for routine nasogastric decompression after extensive resections in patients with gastric cancer. Prospective randomised study. University hospital, Korea. Over a 1-year period (July 1999-July 200), 136 patients with gastric cancer who underwent radical gastrectomy with D2 or more lymph node dis... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does high-density lipoprotein stimulate endothelial cell migration and survival through sphingosine 1-phosphate and its receptors? | [
"Plasma high-density lipoprotein (HDL) level is inversely correlated with the risk of atherosclerosis. However, the cellular mechanism by which HDL exerts antiatherogenic actions is not well understood. In this study, we focus on the lipid components of HDL as mediators of the lipoprotein-induced antiatherogenic ac... | [
"Following injury, fibroblasts transform into myofibroblasts and produce extracellular matrix (ECM). Excess production of ECM associated with cardiac fibrosis severely inhibits cardiac function. Sphingosine-1-phosphate (S1P), a bioactive lysophospholipid, regulates the function of numerous cell types. In this study... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is von Willebrand factor but not alpha-thrombin binding to platelet glycoprotein Ibalpha influenced by the HPA-2 polymorphism? | [
"Glycoprotein (GP) Ibalpha is the functionally dominant subunit of the platelet GPIb-IX-V receptor complex. The N-terminal domain of the GPIbalpha chain contains binding sites for alpha-thrombin and von Willebrand factor (VWF). The human platelet alloantigen (HPA)-2 polymorphism of the GPIbalpha gene is associated ... | [
"Human platelets contain matrix metalloproteinases (MMPs) that are secreted during platelet activation. Platelet MMPs have been implicated in the regulation of cellular activation and aggregation. Although the proaggregatory effect of MMP-2 has been demonstrated, the functional mechanism is not clearly understood. ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2? | [
"We have previously shown that phospholipid oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) inhibit lipopolysaccharide (LPS)-induced E-selectin expression and neutrophil binding in human aortic endothelial cells (HAECs). The current studies identify specific phospholipids t... | [
"Inflammatory injury plays a critical role in intracerebral hemorrhage (ICH)-induced secondary brain injury. However, the upstream events that initiate inflammatory responses following ICH remain elusive. Our previous studies suggested that Toll-like receptor 4 (TLR4) may be the upstream signal that triggers inflam... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do genetic loci contribute to the progression of vascular and cardiac hypertrophy in salt-sensitive spontaneous hypertension? | [
"The salt-sensitive Dahl rat and the spontaneously hypertensive rat develop comparable spontaneous hypertension on a low-salt diet, whereas only the salt-sensitive Dahl rat strain develops a striking increase in blood pressure and cardiovascular hypertrophy on a high-salt diet. We set out to identify quantitative t... | [
"Recent evidence suggests that succinate, long known as an intermediate in the citric acid cycle, may also have a role as a signaling molecule through GPR91 and that activation of this receptor results in blood pressure (BP) elevation via the renin-angiotensin system. We sought to test the hypothesis that GPR91 con... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does magnetic resonance imaging identify cytoarchitectonic subtypes of the normal human cerebral cortex? | [
"Magnetic Resonance Imaging (MRI) allows a detailed \"in vivo\" macroscopic study of the human brain; previously, it has been demonstrated that Fluid Attenuated Inversion Recovery (FLAIR) sequence shows higher signal intensity of cortices belonging to limbic structures. To measure and compare signal intensities (SI... | [
"Parkinson's disease (PD) is a surprisingly heterogeneous neurodegenerative disorder. It is well established that different subtypes of PD present with different clinical courses and prognoses. However, the neural mechanism underlying these disparate presentations is uncertain. Here we used resting-state fMRI (rs-f... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is albumin-adjusted calcium suitable for diagnosis of hyper- and hypocalcemia in the critically ill? | [
"To evaluate whether calcium adjusted for albumin can be used to monitor calcium homeostasis in critically ill patients. Prospective single-single center observational study. Clinical laboratory and critical care unit of a regional teaching hospital. Fifty-three paired samples were from 36 patients requiring intens... | [
"Vitamin D is involved in immune regulation in humans. Vitamin D serum deficiency is reported to be common in hospitalized patients, especially among Intensive Care Unit (ICU) patients. Our aim was to evaluate the relationship between vitamin D levels in septic patients and outcome. A total of 170 patients were stu... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does [ Studies on the chemical constituents of the stem of Alyxia sinensis ( I ) ]? | [
"To demonstrate the chemical constituents of Alyxia sinensis. Phytochmical experiment was carried out, using column chromatograph technologies. Five compounds have been isolated from the petroleum ether soluble part of the stems of A. sinensis. Their structures have been elucidated respectively as heptatriacontane(... | [
"Hydrogen sulfide (H Endothelial cells EAhy 926 were treated with 50 μM of H With the treatment of H"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is intramuscular penicillin more effective than oral penicillin in secondary prevention of rheumatic fever -- a systematic review? | [
"People with a history of rheumatic fever (RF) are at high risk of recurrent attacks and of developing rheumatic heart disease following a streptococcal throat infection. Giving penicillin to these people can prevent recurrent attacks of RF and subsequent rheumatic heart disease. However, there is no agreement on t... | [
"To compare the clinical failure rates among children with otorrhea through tympanostomy tubes treated with topical or systemic antibiotics versus topical saline. Randomized, double-blind, controlled patient study. A three-armed randomized clinical trial using topical ciprofloxacin or oral amoxicillin or topical sa... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does a novel form of pontocerebellar hypoplasia map to chromosome 7q11-21? | [
"To describe a novel form of pontocerebellar hypoplasia (PCH) and map its genetic locus. PCH is a heterogeneous group of disorders that are characterized by abnormally small cerebellum and brainstem. Autosomal recessive inheritance has been implied in many cases, but no genetic loci have been mapped to date. The au... | [
"Because in most patients with mental retardation (MR), who constitute 2 to 3% of the population, the etiology remains unknown, we wanted to identify novel chromosomal candidate regions and genes associated with the MR phenotype. We screened for microimbalances in 60 clinically well-characterized patients with unex... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does [ Diagnostic value and cytomorphologic findings in bone marrow puncture in children with severe deficiency anemia ]? | [
"To determine the diagnostic and prognostic value the bone marrow aspiration in children with severe deficiency anaemia. In this retrospective study we analysed 75 children 0-4 years of age who were diagnosed and treated from severe anaemia (Hb < 8g/dl) at Haematologic outpatient and hospital department of Pediatri... | [
"Reporting a rare case with Kimura's disease and angiolymphoid hyperplasia with eosinophilia (ALHE), who also has nephrotic syndrome resulting from minimal change glomerulopathy. Histological manifestations, immunohistochemical staining, immunofluorescence staining, and electron microscope were performed. One 37-ye... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do macrophages in human reproductive tissues contain luteinizing hormone/chorionic gonadotropin receptors? | [
"To determine whether macrophages in human reproductive tissues contain luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptor mRNA and receptor protein that can bind 125I-hCG. Macrophages isolated from term pregnancy human decidua were used for LH/hCG receptor detection by in situ hybridization for r... | [
"Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic molecule restricted to endocrine glands and, particularly, to steroid-secreting cells. The expression of EG-VEGF and its significance in human adenohypophysis in physiological and pathological conditions is still unknown. In this... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are pre-ovulatory granulosa cells of infertile women with endometriosis less sensitive to luteinizing hormone? | [
"Reduced fertilization rates in women with minor endometriosis may be the result of direct effects on the ovary or to primary dysfunction within the hypothalamic-pituitary-ovarian axis. This controlled study was designed to examine the steroidogenic potential of luteinized granulosa cells in women with minor endome... | [
"This study was to examine the serum leptin levels in the prediction of pregnancy outcomes in women receiving ovarian hyperstimulation. Effect of leptin on the steroidogenesis was evaluated for granulosa cell (GC) culture in vitro. Serum levels of leptin and estradiol were measured on Day 2, the time of hCG adminis... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is elevated serum endostatin associated with poor outcome in patients with non-Hodgkin lymphoma? | [
"Endostatin is a cleaved fragment of collagen Type XVIII and has antiangiogenic activity. The clinical significance of circulating, soluble endostatin (S-endostatin) is not known. Pretreatment S-endostatin and serum vascular endothelial growth factor (S-VEGF) levels were measured in 143 patients with non-Hodgkin ly... | [
"The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues. To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer. A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lu... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does lazaroid attenuate edema by stabilizing ATPase in the traumatized rat brain? | [
"The aim of the present study was to determine the potential therapeutic value of the lazaroid U-83836E on blood brain barrier (BBB) breakdown and edema with respect to the changes in the synaptosomal Na+/K+ and Mg(2+)/Ca(2+)-adenosinetriphosphatase (ATPase) activities, tissue malondialdehyde levels and the neurona... | [
"The mechanical origins of the obstruction in sinusoidal obstruction syndrome are initiated by dehiscence of sinusoidal endothelial cells from the space of Disse. The biochemical changes that permit the dehiscence of the sinusoidal endothelial cells were investigated. In vitro and in vivo studies examined changes i... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do [ The intraoperative application of neural response telemetry with the nucleus CI24M cochlear implant ]? | [
"To test device integrity and objective auditory reaction for cochlear implant patients intraoperatively. Our protocol for intraoperative testing of the implant device includes device electrode impedance test and neural response telemetry (NRT), which measures the electrically evoked auditory nerve compound action ... | [
"Neurally Adjusted Ventilatory Assist (NAVA) offers synchronized proportional pressure in accordance with the electrical activity of the diaphragm (EAdi). NAVA relies on the EAdi to trigger the respiratory cycle and then adjusts the ventilatory assist to the neural drive. The technique necessitates a catheter with ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are major risk factors for aneurysmal subarachnoid hemorrhage in the young modifiable? | [
"To identify risk factors for subarachnoid hemorrhage (SAH) and intracerebral hemorrhage, we designed a case-control study of men and women 18 to 49 years of age (the Hemorrhagic Stroke Project [HSP]). This report focuses on SAH. Patients were recruited from 44 hospitals in the United States. Cases with SAH must ha... | [
"It has been proposed that patients with Marfan syndrome have an increased prevalence of intracranial aneurysms. This proposition is based on 10 clinical reports, 1 pathology case, and an autopsy series of 7 patients. By contrast, 5 clinical series of Marfan patients have failed to document any such relationship. W... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is acute pain underassessed in out-of-hospital emergencies? | [
"To evaluate the quality of pain assessment by emergency medical services (EMS) in out-of-hospital emergencies. A prospective study was conducted on a convenience sample of patients during a one-year observation period. Pain ratings assessed by emergency patients were documented at three different intervals during ... | [
"Is optimal adherence to guideline recommendations in intrauterine insemination (IUI) care cost-effective from a societal perspective when compared with suboptimal adherence to guideline recommendations?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is the surgical error examination a novel method for objective technical knowledge assessment? | [
"Objective analysis of surgical skill is necessary. A novel method of assessment using simple error analysis in synthetic models is examined for construct validity. Two examination protocols were devised using synthetic models. These contained either a purpose made error or were representative of good surgical prac... | [
"This study aimed to investigate the effect of a virtual reality simulator on the learning of basic robotic suturing skills. Two randomized groups of students underwent a controlled training program. Both groups completed an identical test before and after training. The increase in the number of stitches placed dur... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does hypertension increase expression of growth factors and MHC II in chronic allograft nephropathy? | [
"Hypertension of the recipient is strongly associated with chronic allograft nephropathy. It is unclear, however, whether hypertension is the cause or the consequence of chronic allograft nephropathy. The present study was performed in the Fisher to Lewis rat kidney transplant model. Transplanted rats (N = eight in... | [
"Genetic manipulation of the allograft is an attractive approach to prevent the graft against chronic deterioration through stable expression of immunomodulatory or protective genes. However, the best strategy for prevention of chronic allograft deterioration remains unclear. The efficacies of adeno-associated vira... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does suboptimal restraint affect the pattern of abdominal injuries in children involved in motor vehicle crashes? | [
"Both solid and hollow visceral abdominal injuries have been associated with the use of seat belts in children involved in motor vehicle crashes. The relationship between the types of restraint used and the pattern of abdominal injury is unknown. A probability sample of restrained children involved in crashes was e... | [
"To analyse the relationship between motor vehicle collision factors and TBI. Retrospective design analysed the difference between the types of brain injuries sustained in distinct collision configurations. Medical charts and police accident reports were reviewed for individuals sustaining TBI in 168 motor vehicle ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does nitric oxide open second window of protection in ischemic preconditioning via induction of heat-shock protein 72? | [
"To examine the inhibition of nitric oxide (NO) synthesis during ischemic preconditioning (IP) upon the induction of heat-shock protein 72 (HSP72) and the size-limiting effect of the second window of protection on infarction. Rabbits were subjected to either 4 cycles of 5-min long coronary artery occlusion separate... | [
"Silent information regulator 1 (Sirt1), a class III histone deacetylase, retards aging and protects the heart from oxidative stress. We here examined whether Sirt1 is protective against myocardial ischemia/reperfusion (I/R). Protein and mRNA expression of Sirt1 is significantly reduced by I/R. Cardiac-specific Sir... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does oscillatory shear stress increase smooth muscle cell proliferation and Akt phosphorylation? | [
"Hemodynamic forces affect smooth muscle cell (SMC) proliferation and migration both in vitro and in vivo. However, the effects of oscillatory shear stress (SS) on SMC proliferation and signal transduction pathways that control survival are not well described. Bovine aortic SMC were exposed to arterial levels of os... | [
"We recently found low level of tumor suppressor programmed cell death 4 (PDCD4) associated with reduced atherosclerotic plaque area (unpublished). We investigated whether atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells. En face co-immunostaining of the mo... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does unsteadiness reported by older hospitalized patients predict functional decline? | [
"To determine whether a simple question about steadiness at admission predicts in-hospital functional decline and whether unsteadiness at admission predicts failure of in-hospital functional recovery of patients who have declined immediately before hospitalization. Prospective cohort study. One university hospital ... | [
"To determine whether low educational level is associated with poor functional recovery after hospitalization in older adults. We followed 862 patients (374 with low education, defined as <high school) for 6 months after hospitalization. Poor functional recovery was defined as an Activities of Daily Living score th... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibit hepatocyte growth factor/scatter factor-induced angiogenesis? | [
"Hepatocyte growth factor/scatter factor (HGF/SF) can sufficiently and independently induce pathophysiological angiogenesis. However, the treatment strategies have mostly been unsuccessful. The present study is the first to evaluate the possible targeting of downstream signals for the inhibition of HGF/SF-induced a... | [
"Nicotine, the major component in cigarette smoke, can promote tumor growth and angiogenesis in various cancers, including lung cancer. Hypoxia-inducible factor-1alpha (HIF-1alpha) is overexpressed in human lung cancers, particularly in non-small cell lung cancers (NSCLC), and is closely associated with an advanced... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are nutrient intake and iron status of urban poor and rural poor without access to rice fields affected by the emerging economic crisis : the case of pregnant Indonesian women? | [
"We evaluated the adequacy of nutrient intake in comparison with the Indonesian Estimated Average Requirement (EARs) among pregnant Indonesian women and explain the short-term effect of economic crisis on nutrient intake and iron status. Cross-sectional study. Purworejo District, Central Java, located 60 km west of... | [
"Although animal-source foods provide a rich source of complete protein and a variety of micronutrients, a majority of these foods are not accessible to a large proportion of populations in low-income nations. Locally available and affordable nutrient-dense dietary solutions that are accessible all year round can p... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does the bifunctional rat pancreatic secretory trypsin inhibitor/monitor peptide provide protection against premature activation of pancreatic juice? | [
"In the rat, two forms of the pancreatic secretory trypsin inhibitor, PSTI-I and PSTI-II, are secreted into pancreatic juice. It is assumed that their role is to protect the pancreas from premature activation of the protease-rich pancreatic juice. In the small intestine, PSTI-I, also called 'monitor peptide', is th... | [
"Activation of trypsinogen to trypsin is a crucial step in the development of acute pancreatitis. The cause of this activation is not known although suggested explanations include autoactivation, cathepsin B-mediated activation and activation by mast cell tryptase. The aim of this study was to investigate cathepsin... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does topical medication interfere with face-down positioning after macular hole surgery? | [
"To investigate whether different procedures of topical medication interfere with postoperative face-down positioning and thereby influence the anatomical success rate of macular hole surgery. A total of 39 consecutive eyes with macular holes were operated with vitrectomy and fluid-gas exchange, followed by face-do... | [
"To investigate the therapeutic effects of a local ice compress in alleviating eyelid swelling and errhysis and providing relief from pain after surgery. Eyelid swelling and pain are the most common postoperative symptoms after scleral buckling surgery. A local ice compress can reduce the severity of swelling, errh... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is the corticotrophin-releasing hormone test the most reliable noninvasive method to differentiate pituitary from ectopic ACTH secretion in Cushing 's syndrome? | [
"It has been reported previously that the paired interpretation of the corticotrophin-releasing hormone (CRH) test and the 8-mg dexamethasone suppression test (HDDST) could have higher diagnostic power than any single test in the differential diagnosis of ACTH-dependent Cushing's syndrome. This finding has not been... | [
"Ectopic Cushing syndrome due to ACTH secretion from metastatic medullary thyroid cancer (MTC) is associated with significant morbidity and mortality. The aim of the study was to describe the first case of Cushing syndrome associated with MTC in a pediatric patient and the successful reversal of Cushing syndrome wi... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does intraspinal adenosine induce spinal cord norepinephrine release in spinal nerve-ligated rats but not in normal or sham controls? | [
"Intrathecal adenosine is antinociceptive under conditions of central sensitization, but not in response to acute stimuli in normals. The reasons for this selective circumstance of action remain unclear, but some evidence links adenosine's antinociceptive effects to release of norepinephrine by terminals in the spi... | [
"Brain-derived neurotrophic factor (BDNF) and its cognate receptor, the tyrosine kinase B (TrkB), are normally expressed in neurons and implicated in multiple pathological conditions. Brain-derived neurotrophic factor is produced in the central nervous system microglia in response to noxious stimuli and appear to p... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are postoperative morphine use and hyperalgesia reduced by preoperative but not intraoperative epidural analgesia : implications for preemptive analgesia and the prevention of central sensitization? | [
"The aim of this study was to evaluate the postoperative morphine-sparing effects and reduction in pain and secondary mechanical hyperalgesia after preincisional or postincisional epidural administration of a local anesthetic and an opioid compared with a sham epidural control. Patients undergoing major gynecologic... | [
"N-methyl-D-aspartate (NMDA) antagonists administered before surgery will improve postoperative analgesia, presumably by inhibiting spinal sensitization processes. However, current clinical formulations of NMDA antagonists either enable only an oral application (i.e., dextromethorphan) or are associated with psycho... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does intrathecal morphine reduce the visceromotor response to acute uterine cervical distension in an estrogen-independent manner? | [
"Acute uterine cervical distension (UCD) forms the basis for obstetric and some gynecologic pain. Systemic morphine inhibits the visceromotor response to UCD in rats by an action in the central nervous system, but the effect of morphine is blocked by exposure to estrogen. The purpose of the present study was to det... | [
"The aims of this study were to investigate the effects of ovalbumin challenge on uterine and cervical contractility, intrauterine pressure, and uterine electromyography activity in sensitized guinea pigs. Guinea pigs were sensitized by injection of ovalbumin-aluminum hydroxide suspension. Control animals were inje... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is electro-anatomic mapping of the right atrium : anatomic abnormality an important substrate? | [
"To map and compare the right atrium in patients with AF to those with atrioventricular nodal reentrant tachycardias (AVNRT, as control group) and to investigate the anatomical and electrophysiological abnormality of the right atrium in AF. The anatomy and electrophysiology of right atrium and cavotricuspid isthmus... | [
"Persistent left superior vena cava (PLSVC) is a structural, asymptomatic and infrequent anomaly, present in 0.5% of the general population. Typically the diagnosis reveals itself unexpectedly at the time of pacemaker implantation, when it acquires anatomic relevancy. Several techniques are used for the transvenous... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do adolescent girls ' personal experience with Baby Think It Over infant simulator? | [
"To explore adolescent girls' personal experience with an infant simulator that had to be cared for over a period of 1 to 2 weeks. This qualitative study employed the phenomenological approach and utilized Colaizzi's method of analysis. Participants were nine adolescent high school girls who were interviewed and au... | [
"To present the evidence that alcoholism is a disease."
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do [ Clinical application of the multichannel auditory brainstem implant ]? | [
"To investigate the surgical techniques and speech performance of multichannel auditory brainstem implant (ABI) in patients with bilateral acoustic neuromas (neurofibromatosis type 2). The nucleus 21 channel auditory brainstem implant was implanted into the lateral recess of the fourth ventricle through the transla... | [
"A case of focal damage to the iris with distortion of the pupil secondary to PhotoDerm therapy in a 2-year-old boy is reported. To study ocular complication of photoDerm VL therapy for facial port-wine stain. METHODS. : Observatory case report. PhotoDerm VL therapy may damage ocular tissues."
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does foam during reconstitution affect the potency of botulinum toxin type A? | [
"Among factors that may affect the potency of botulinum toxin A (Botox), it is said that foam, together with bubbles, may cause surface denaturation of the toxin. To determine whether the muscle relaxation effect of Botox is preserved and has the same duration when it is reconstituted in the presence of foam. Six f... | [
"Botulinum neurotoxins act on nerve endings and block neurotransmitter release. Their potency is due to their enzymatic activity and high affinity binding to neurons. Botulinum toxin type A is used in the treatment of human diseases characterized by hyperactivity of peripheral cholinergic nerve terminals, but some ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do deep resting glabellar rhytides respond to BTX-A and Hylan B? | [
"BTX-A is the standard treatment for glabellar furrows. However, some individuals have resting glabellar rhytides that are sufficiently deep that they respond poorly to BTX-A alone. To compare the efficacy of BTX-A combined with intradermal Hylan B with the efficacy of BTX-A alone in individuals with moderate to se... | [
"Periorbital aging and lines are a result of intrinsic skin aging, ultraviolet damage, and repetitive action of periorbital muscles. Rejuvenation of this area should therefore be optimized by combining treatments that approach the different causative factors. This was a single-center, prospective, randomized, place... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does corneal thickness result in the Menicon Z 30-day continuous wear and ACUVUE 7-day extended-wear contact lens clinical trial? | [
"This study was conducted to measure the corneal thickness changes associated with wearing 30-day tisilfocon A (Dk = 163) and 6-day etafilcon A (Dk = 28) contact lenses. The probable cause of the outcomes is discussed. Thirty subjects were fitted with Menicon Z rigid gas-permeable (RGP) contact lenses and a control... | [
"This study evaluated the efficacy of custom-made reverse geometry rigid gas permeable (RGP) contact lenses in the control of symptoms related to increased wavefront aberrations after LASIK correction of myopia. Twenty-eight myopes treated with LASIK were assessed for post-LASIK symptoms (declined night vision, gla... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does exercise training counteract the abnormal release of plasma endothelin-1 in normal subjects at risk for hypertension? | [
"The hypothesis that in normotensive offspring of hypertensive parents exercise training could influence the systemic release of endothelin (ET)-1 during a provocative testing protocol was tested. The provocative handgrip test was performed in four groups of healthy young age-matched males: offspring of hypertensiv... | [
"Enhanced and prolonged postprandial lipaemia is associated with coronary heart disease (CHD). However, the mechanisms linking postprandial lipaemia to the increased risk of atherosclerosis and CHD remain to be determined. The aim of the present study was to examine the effects of a high-fat meal on plasma levels o... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are patients with chronic heart failure encountered in daily clinical practice different from the `` typical '' patient enrolled in therapeutic trials? | [
"The aim of this study was to compare the clinical characteristics of patients enrolled in randomized clinical trials on congestive heart failure treatment with those of real-world patients encountered in daily clinical practice. We searched the Cochrane review methodology, Medline and SilverPlatter databases to ob... | [
"Treatment with an angiotensin-converting enzyme (ACE) inhibitor benefits many patients with cardiovascular disease. ACE inhibitors are generally assumed to be equally effective, but this has never been fully verified in clinical trials."
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is topotecan an active agent in the first-line treatment of metastatic or recurrent endometrial carcinoma : Eastern Cooperative Oncology Group Study E3E93? | [
"To determine the clinical activity and the toxicity profile of the topoisomerase-I inhibitor, topotecan, in women with recurrent or advanced endometrial carcinoma. A prospective, phase II clinical trial was initiated by the Eastern Cooperative Oncology Group (ECOG). Patients had histologically confirmed advanced o... | [
"To review the management of Wilms' tumour. A search of the literature was performed using the PubMed database (1966 to May 2006) with the search terms 'Wilms' and either 'tumour/tumor' or 'cancer' or 'carcinoma'. This was augmented by manual searches of publications. The success of clinical trials in Wilms' tumour... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is rabeprazole superior to omeprazole for the inhibition of peptone meal-stimulated gastric acid secretion in Helicobacter pylori-negative subjects? | [
"Peptone meal-stimulated gastric acid output is considered to be a reliable means to evaluate drug-mediated inhibition of stimulated gastric acid output, an important measure of the efficacy of the agents--such as proton pump inhibitors--used to treat acid-related disorders. To compare the initial and overall inhib... | [
"The acid inhibitory effect of proton pump inhibitors is reported to be greater in the presence than in the absence of an H. pylori infection. This study was undertaken to test the hypothesis that the acid inhibitory effect of omeprazole given twice a day is greater in H. pylori infected healthy volunteers than in ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is circulating adrenomedullin increased in relation with increased creatinine and atrial natriuretic peptide in liver-transplant recipients? | [
"Circulating adrenomedullin (ADM), a potent vasorelaxing and natriuretic peptide involved in cardiovascular homeostasis, is increased after cardiac and renal transplantation. ADM is also implicated in hemodynamic abnormalities during liver cirrhosis, but whether ADM is increased late after liver transplantation is ... | [
"Models of fatty liver diseases and fibrosis suggest a hepatoprotective effect of adiponectin, an adipocyte-derived hormone with antidiabetic, antiobesity, antiatherogenic and anti-inflammatory effects. We studied adiponectin serum levels in 111 chronic liver disease (CLD) patients and 226 healthy controls and the ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does a family history of smoking predict heightened levels of stress-induced cigarette craving? | [
"Individuals with histories of smoking in first-degree relatives are significantly more likely to be persistent smokers themselves. The mechanisms underlying this relationship are unknown. Considerable research has demonstrated that smokers display heightened levels of cigarette craving after being exposed to stres... | [
"Vulnerability factors like respiratory sinus arrhythmia (RSA) may help identify adolescents at risk for nicotine dependence. We examined if resting RSA and the acute effects of smoking on RSA was associated with cigarette smoking five years later among adolescents at high risk for smoking escalation and nicotine d... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are early changes in left ventricular volume and function predictors for long-term remodeling in patients with acute transmural myocardial infarction and preserved systolic function? | [
"We sought to describe the degree of long-term left ventricular (LV) remodeling after acute transmural myocardial infarction with preserved LV systolic function, and to evaluate whether Doppler echocardiographic parameters in the early phase could predict this process. A total of 60 patients without heart failure a... | [
"Anaesthetics may have protective effect against myocardial ischemia. We aimed to investigate if sevoflurane administration could exert myocardial protection during following coronary occlusion in patients with coronary artery disease. a). prospective, randomized study. b). University Hospital, cardiac surgical ope... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do drainage of deep pelvic abscesses using therapeutic echo endoscopy? | [
"The purpose of this study was to evaluate the clinical efficacy of endosonographically guided transrectal aspiration and drainage by plastic stent of deep pelvic abscesses, using a therapeutic echo endoscope device. Between September 2000 and June 2001, 12 patients (nine men, three women, mean age 67 years) were t... | [
"We investigated the association of carbon dioxide absorption with the approach (transperitoneal versus extraperitoneal) and other factors during laparoscopy. Carbon dioxide elimination during laparoscopic renal surgery was retrospectively calculated in 63 patients. Carbon dioxide elimination increased with time. M... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does functional response of bladder strips from streptozotocin diabetic rats depend on bladder mass? | [
"We investigated the relationship of bladder mass to responses to electrical field stimulation and adrenergic agonists in diabetic rat bladders. Longitudinal strips were removed from the ventral and dorsal detrusor of age matched control, 2-month diabetic and sucrose drinking rats. Contractile responses to electric... | [
"Coptidis Rhizoma has been used to treat diabetes mellitus for more than 1400 years in China. Berberine, one of the main alkaloids of Coptidis Rhizoma, is a principal antidiabetic component of Coptidis Rhizoma. To investigate the effects of berberine on impaired neurogenic contractility of detrusor muscle from urin... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does cyclic AMP activate B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys? | [
"The proliferation of mural epithelial cells is a major cause of progressive cyst enlargement in autosomal-dominant polycystic kidney disease (ADPKD). Adenosine 3', 5' cyclic monophosphate (cAMP) stimulates the proliferation of cells from ADPKD cysts, but not cells from normal human kidney cortex (HKC), through the... | [
"Polycystic kidney disease (PKD) is a genetic disorder characterized by development of renal cysts and progressive renal dysfunction. Renal tissues from both PKD patients and rodent models of PKD show elevated c-myc expression. Prothymosin alpha (ProT) is positively regulated by c-myc through binding to the E box o... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does accelerometry of adductor pollicis muscle predict recovery of respiratory function from neuromuscular blockade? | [
"Residual paralysis increases the risk of pulmonary complications but is difficult to detect. To test the hypothesis that accelerometry predicts effects of residual paralysis on pulmonary and upper airway function, the authors related tests of pulmonary and pharyngeal function to accelerometry of adductor pollicis ... | [
"The muscle weakness that is exhibited poststroke is due to a multifactorial etiology involving the central nervous system and skeletal muscle changes. Insulinlike growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) have been described as biomarkers of neuromuscular performance in many conditions. However, ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does propofol increase phosphorylation of troponin I and myosin light chain 2 via protein kinase C activation in cardiomyocytes? | [
"Troponin I (TnI) and myosin light chain 2 (MLC2) are important myofibrillar proteins involved in the regulation of myofilament calcium (Ca2+) sensitivity and cardiac inotropy. The objectives of this study were to determine the role of protein kinase C (PKC) in mediating propofol-induced changes in actomyosin adeno... | [
"To address the pathophysiological relevance of ovarian hormones in chronic beta-adrenergic stimulation-induced myocardial injury, we assessed impairments of Ca(2+)-mediated cell signaling in the left ventricle of ovariectomized female rats. Female Wistar rats were subjected to bilateral ovariectomy and sham operat... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does vitamin C protect against lysophosphatidylcholine-induced expression of monocyte chemoattractant protein-1 in cultured human umbilical vein endothelial cells? | [
"It is well documented that oxidized low-density lipoproteins (LDLs) can stimulate human vascular endothelial cells to produce monocyte chemoattractant protein-1 (MCP-1). Vitamin C is known to be an important antioxidant for vasodilatation. The purpose of this study was to determine whether pretreatment with vitami... | [
"Interleukin (IL)-33 is the most recently described member of the IL-1 family of cytokines and it is a ligand of the ST2 receptor. While the effects of IL-33 on the immune system have been extensively studied, the properties of this cytokine in the cardiovascular system are much less investigated. Methods/Results- ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do [ Localization of upper airway stricture in patients with obstructive sleep apnea syndrome by CT scan ]? | [
"To evaluate the diagnostic significance of CT scan in the localization of the stricture in the upper airway in patients with obstructive sleep apnea syndrome (OSAS). Fifty-four patients with OSAS were included in this study. CT scan evaluated the upper airway from the roof of nasopharynx to the glottis using a Phl... | [
"Hematopoietic Stem Cell Transplant (HSCT) causes immunosuppression and predisposition to sinusitis. CT scans are complementary exams used in the diagnosis of sinusitis; however, its use in every patient is questionable. to check the usefulness of ordering a CT scan prior to HSCT and to study the relationship betwe... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do short bursts of weak pulses break postictal inhibition in the neocortex of Wistar rats? | [
"Postictal inhibition (PI) is a decrease in excitability that follows an epileptic seizure and decreases probability of new seizure occurrence. PI may involve both increased inhibition and persisting elevated excitation. Our experiments tested whether shorter trains of weak stimuli are able to unmask this residual ... | [
"To investigate in vitro, the cellular network activity of the hippocampus in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene. Extacellular recordings were obtained from CA1 and CA3 pyramidal neurons in hippocampal slices prepared from Q54 transgeni... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is neuronal cell death in a rat model for mesial temporal lobe epilepsy induced by the initial status epilepticus and not by later repeated spontaneous seizures? | [
"To determine whether repeated seizures contribute to hippocampal sclerosis, we investigated whether cell loss in the (para) hippocampal region was related to the severity of chronic seizure activity in a rat model for temporal lobe epilepsy (TLE). Chronic epilepsy developed after status epilepticus (SE) that was e... | [
"To evaluate the efficacy of NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f) quinoxaline-2,3-dione) and topiramate (TPM) given after hypoxia-induced seizures in preventing the delayed effect of hypoxia on subsequent susceptibility to seizures and neuronal injury. We used \"two-hit\" rodent seizure model to study th... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is insulin resistance related to left ventricular hypertrophy in patients with polycystic kidney disease type 1? | [
"Left ventricular hypertrophy (LVH) is common in patients with autosomal dominant polycystic kidney disease (ADPKD). Although insulin resistance contributes to cardiac hypertrophy, the relationship between insulin resistance and LVH in patients with ADPKD has not been previously studied. We performed M-mode and col... | [
"Do teenage girls with a history of menstrual irregularity and/or elevated androgen levels in adolescence exhibit an increased risk of polycystic ovary syndrome (PCOS) and/or infertility later on in adulthood?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do [ Values of soluble thrombomodulin and von Willebrand factor judging reject reaction in liver transplantation ]? | [
"To find sensitive and specific laboratory examination items for early diagnosing and monitoring liver transplantation reject reaction. Randomly investigate 41 liver transplantation patients, among them there were 16 patients with reject reaction (including 12 with acute rejection, 4 with chronic rejection). Plasma... | [
"Essentials Joint bleeding in hemophilia may induce significant remodeling of the extracellular matrix. Biomarkers of collagen turnover were investigated in a F8"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does two-hour insulin determination improve the ability of abdominal fat measurement to identify risk for the metabolic syndrome? | [
"Visceral obesity is shown to be a predictor of morbidity and mortality. We evaluated the association of measurements of generalized adiposity and visceral fat area (VFA), with abnormalities of metabolic syndrome (MS). Seventy-six women (47.9 +/- 9.2 years) with BMI of 38.7 +/- 5.4 kg/m(2) underwent anthropometric ... | [
"Elevated intraocular pressure (IOP), a well-known risk factor for glaucoma, has recently been shown to be associated with some metabolic complications and obesity. We investigated the link between IOP and metabolic disturbances, focusing especially on metabolic syndrome and insulin resistance. Eye examinations, in... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is a simple meal plan emphasizing healthy food choices as effective as an exchange-based meal plan for urban African Americans with type 2 diabetes? | [
"To compare a simple meal plan emphasizing healthy food choices with a traditional exchange-based meal plan in reducing HbA(1c) levels in urban African Americans with type 2 diabetes. A total of 648 patients with type 2 diabetes were randomized to receive instruction in either a healthy food choices meal plan (HFC)... | [
"What are the lifestyle choices and dietary aspects of women about to undergo fertility treatment in New Zealand?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is anaemia in the first but not in the second or third trimester a risk factor for low birth weight? | [
"To assess pregnancy outcome in women with anaemia during pregnancy. The study design involved a retrospective chart review of all women registering for prenatal care in the area of Kuopio University Hospital between 1990 and 2000. A haemoglobin concentration below 100g/l was used as a cutoff for anaemia and affect... | [
"Does extended embryo culture have a different effect on the birthweight of girls and boys?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does methylprednisolone inhibit low-flow hypoxia-induced mitochondrial dysfunction in isolated perfused rat liver? | [
"To investigate the mechanism by which methylprednisolone protects the liver from hypoxia-induced injury. Prospective control study using the isolated rat liver. Animal research facility. Male, fasted, pathogen-free Sprague-Dawley rats. Low-flow hypoxia was produced by reducing afferent perfusate pressure from 10 t... | [
"Excessive oxidative stress is a main cause of lung ischemia-reperfusion injury, which often results in respiratory insufficiency after open-heart surgery for a cardiopulmonary bypass. Previous studies demonstrate that the activation of aldehyde dehydrogenase-2 could significantly reduce the oxidative stress mediat... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is reduction in alkaline sphingomyelinase in colorectal tumorigenesis related to the APC gene mutation? | [
"The sphingomyelin pathway is an important intracellular mechanism in regulating cell growth. The first step in this pathway is catalysed by sphingomyelinases. Alkaline sphingomyelinase is specifically located in the intestinal tract. Markedly reduced alkaline sphingomyelinase activities have been found in sporadic... | [
"Aortic dissection or rupture resulting from aneurysm causes 1% to 2% of deaths in developed countries. These disorders are associated with mutations in genes that affect vascular smooth muscle cell differentiation and contractility or extracellular matrix composition and assembly. However, as many as 75% of patien... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are angiogenesis and dendritic cell density correlated with metachronous distant metastasis in curatively operated rectal cancer? | [
"Apart from surgery, treatment of rectal cancer increasingly involves the use of (neo-)adjuvant strategies. To optimize the selection process for these therapy regimens, especially in the field of cellular and molecular biology, new prognostic factors additional to the established TNM system are being investigated.... | [
"Increased expression of polymeric immunoglobulin receptor (pIgR) in tumor tissue has been detected in various cancer forms. However, the clinical relevance of pIgR in colon cancer hepatic metastasis remains uncertain. The aim of this study was to assess the prognostic value of pIgR in patients with colon carcinoma... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is neutrophil survival on biomaterials determined by surface topography? | [
"Cardiovascular device-centered infections are a major cause of hospital morbidity, mortality, and expense. Caused by opportunistic bacteria, this phenomenon is thought to arise because of a defect in neutrophil bacterial killing. We have shown that neutrophils that adhere to polystyrene remain viable, whereas neut... | [
"Thrombin concentration modulates fibrin structure and fibrin structure modulates clot stability; however, the impact of localized, cell surface-driven in situ thrombin generation on fibrin structure and stability has not previously been evaluated. Human fibroblasts were incubated with factors Xa, Va, prothrombin a... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are dermatologist detection and skin self-examination associated with thinner melanomas : results from a survey of the Italian Multidisciplinary Group on Melanoma? | [
"To investigate patterns of detection and variables associated with early diagnosis of melanoma in a population at intermediate melanoma risk. Survey. Hospital and university centers belonging to the Italian Multidisciplinary Group on Melanoma. Eight hundred sixteen patients who were consecutively diagnosed as havi... | [
"Accurate diagnosis of melanocytic lesions is essential for the adequate clinical management of patients. Thus, thorough reporting of histopathologic parameters, especially in the initial biopsies, is a critical component of both diagnosis and staging. To review current data on histopathologic prognostic factors fo... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does recombinant prostate specific antigen inhibit angiogenesis in vitro and in vivo? | [
"Prostate specific antigen (PSA) is a kallikrein family member with serine protease activity commonly used as a diagnostic marker for prostate cancer. We recently described anti-angiogenic properties of PSA [Fortier et al.: JNCI 91:1635-1640]. Two forms of PSA were cloned and expressed in Pichia pastoris: one, an i... | [
"Does halofuginone (HF) inhibit the growth of human uterine leiomyoma cells in a mouse xenograft model?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do pyrethroid insecticides influence the signal transduction in T helper lymphocytes from atopic and nonatopic subjects? | [
"Pyrethroids are claimed to have a low human toxicity with some neuro- and immunotoxicity. The objective of this study was to investigate the immunotoxicological properties of six commercially used pyrethroids, including natural pyrethrum and synergist piperonyl-butoxide (PBO). PHA-stimulated cultures of T-helper l... | [
"Previous studies have shown that delayed neutrophil apoptosis is associated with chronic airway diseases. Leptin is an adipocyte-derived hormone that acts as a regulator of energy homeostasis and food intake. Emerging evidence suggests that leptin can regulate immune responses including the release of proinflammat... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is [ No switch region found in the regulatory sequence of HPV 16 for promoter P97 ]? | [
"Cellular transcriptional regulatory factor YY1 represses the activity of the early promoter P97 of HPV 16, but the regulatory activity to early promoter P105 of HPV 18 depends on a switch region which locates at the upstream sequences of YY1 binding sites. This study is to find out whether within the HPV 16 LCR th... | [
"Hydrogen sulfide (H Endothelial cells EAhy 926 were treated with 50 μM of H With the treatment of H"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does [ Establishment of a method for classification of HBV genome and it 's application ]? | [
"By using the techniques of PCR and restriction fragment length polymorphism (RFLP), we established a classification method for HBV genome based on viral S gene of asymptomatic HBV carriers (AsC). By using this method we classified HBV DNA of AsC living in Guangzhou, Shenyang, Beijing and Chongqing. Among the AsC o... | [
"To investigate the existence condition of hepatitis B surface antigen(HBsAg) termination codon bias. A total of 174 reference sequences of all kinds of Hepatitis B virus(HBV) genotypes were chosen from GenBank, and compared by BioEdit. Then secondary structure of RNA was constructed and analyzed together. (1) Ther... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is left ventricular dysfunction associated with CD4 lymphocyte count rather than opportunistic infection in human immunodeficiency virus infection? | [
"Left ventricular (LV) dysfunction is often found in the early stage of human immunodeficiency virus (HIV) infection and deteriorates with disease progression. CD4 lymphocyte count and opportunistic infection are the major indicators for the clinical staging of HIV infection. This study investigated the association... | [
"To evaluate the prevalence of retinal microangiopathy in human immunodeficiency virus (HIV)-1-infected patients and its association with virologic, immunologic, and sociodemographic parameters. Single-center cross-sectional study. One hundred eighty-eight HIV-1-positive individuals from a single outpatient clinic.... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do cryo-thawed embryos obtained from conception cycles have double the implantation and pregnancy potential of those from unsuccessful cycles? | [
"The purpose of this study was to evaluate the influence of fresh IVF/ICSI cycle outcome on the prognosis of the related frozen embryo replacement (FER) cycle. 459 FER cycles, involving 2049 cleavage stage embryos with no or up to 10% fragmentation, were performed for which the outcome of the fresh cycle was record... | [
"To determine the effect of transvaginal ultrasound-guided ET in IVF cycles performed on patients who had previously failed to conceive from IVF and compare the results to previous cycles where ultrasound guidance was not used. Retrospective clinical study. Private practice IVF program. One hundred twenty-nine wome... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do psychological distress and pain significantly increase before death in metastatic breast cancer patients? | [
"This study was designed to examine the course of psychological distress and pain from study entry to death in 59 women with metastatic breast cancer participating in a randomized trial of the effects of group psychotherapy on psychosocial outcomes and survival. It was hypothesized that psychological distress would... | [
"Insomnia affects between 30% to 60% of patients with cancer but to the authors' knowledge little is known regarding factors associated with its development. It has been postulated that adjuvant cancer treatments and their side effects could trigger sleep disturbances in this population but empirical evidence is la... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are men with colorectal cancer predisposed to prostate cancer? | [
"The objective of the present study was to investigate the relationship between colorectal and prostate cancer. All Victorian men who developed metachronous colorectal and prostate cancer with the first primary diagnosed between 1982 and 1993 were identified retrospectively from the Victorian Cancer Registry and we... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is peroxynitrite-induced oxidation of plasma lipids enhanced in stable hemodialysis patients? | [
"The relationship between end-stage renal disease (ESRD), hemodialysis, and oxidative stress is controversial. To determine whether ESRD causes oxidative stress, we measured basal levels of plasma F2-isoprostanes as a marker of lipid peroxidation in vivo, and peroxynitrite-stimulated formation of F2-isoprostanes, a... | [
"Recent work has shown that humans are significantly exposed to isocyanic acid/cyanate, which is generated when coal, biomass, or tobacco is burned. In vivo, cyanate is formed by the phagocyte protein myeloperoxidase and by breakdown of urea. Carbamylation of proteins through cyanate has been demonstrated to predic... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does hypertension superimposed on type II diabetes in Goto Kakizaki rats induce progressive nephropathy? | [
"Type II diabetes in the Goto Kakizaki (GK) rats (derived from Wistar rats) is not associated with the development of obesity, hyperlipidemia, hypertension, or pronounced renal functional changes. The aim of this study was to investigate the effect of superimposed hypertension on renal function and morphology under... | [
"Diets high in saturated fat are thought to be a risk factor for Type 2 diabetes and associated complications. We investigated effects of a medium and high saturated fat diet on the development of diabetes-associated pathologies in Golden Syrian hamsters, an animal that reacts to dietary lipids in a fashion similar... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does cell senescence in rat kidneys in vivo increase with growth and age despite lack of telomere shortening? | [
"Somatic cells in vitro have a finite life expectancy before entering a state of senescence, but it is unclear whether this state occurs in vivo in kidney development, growth, and aging. We previously showed that human kidney cortex displays telomere shortening with age. In this study, we compared the structural an... | [
"Germline mutations in the enzyme telomerase cause telomere shortening, and have their most common clinical manifestation in age-related lung disease that manifests as idiopathic pulmonary fibrosis. Short telomeres are also a unique heritable trait that is acquired with age. We sought to understand the mechanisms b... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is hypocitraturia one of the major risk factors for nephrocalcinosis in very low birth weight ( VLBW ) infants? | [
"Very low birth weight (VLBW) infants are at risk to develop nephrocalcinosis (NC). NC may result from spontaneous or therapy-induced imbalance between promoters and inhibitors of crystallization in the urine. However, data on \"normal\" urinary excretions of these parameters in VLBW infants are sparse. Therefore, ... | [
"Very low birth weight (VLBW) infants are at high risk for morbidity and mortality. This article determines the frequency of disease, rate od survival, complications and risk factors for morbidity and mortality in VLBW neonates admitted to a level III neonatal intensive care unit (NICU) at Mahdieh Hospital in Tehra... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is very low-density lipoprotein-apoprotein CI increased in diabetic nephropathy : comparison with apoprotein CIII? | [
"Recent studies have suggested that apoprotein (apo) CI in very low-density lipoprotein (VLDL) plays an important role in causing hypertriglyceridemia independent of apo CIII, which is associated with coronary heart disease (CHD). Because the incidence of CHD is increased in diabetic patients and is even higher whe... | [
"Oxidative stress plays an important role in the pathogenesis of coronary artery disease. Recent work showed that high-density lipoproteins isolated from atherosclerotic lesions and blood of patients with established coronary artery disease contain elevated levels of nitrated apolipoprotein A-I. Methods to quantify... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is contralateral groin exploration justified in infants with a unilateral inguinal hernia? | [
"Contralateral groin exploration in children with unilateral inguinal hernia is still controversial, particularly in infants. The patency rate of processus vaginalis is highest in infants but there are few data on the subsequent risk of contralateral hernia development in infants. In this retrospective study, we ai... | [
"Treatment of neonatal testicular torsion has two objectives: salvage of the involved testicle (which is rarely achieved) and preservation of the contralateral gonad. The second goal universally involves contralateral testicular scrotal fixation to prevent the future occurrence of contralateral torsion. However, th... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does anti-CD25 monoclonal antibody therapy affect the death signals of graft-infiltrating cells after clinical heart transplantation? | [
"To define whether immunosuppressive agents that block the interleukin (IL)-2 pathway could prevent activation-induced cell death of activated T cells in the graft, we measured expression of IL-2, IL-2 receptor alpha chain (CD25), IL-15, Fas, and Fas ligand by real time reverse transcription-polymerase chain reacti... | [
"Immune responses are tempered in immunologically privileged sites including the testis. Previous studies have shown that islet transplantation in the testis significantly prolongs islet allograft survival. However, mechanisms underlying testicular immune privilege and intratesticular allograft survival remain uncl... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does starch in plasterboard sustain Streptomyces californicus growth and bioactivity of spores? | [
"The effects of plasterboard composition on Streptomyces californicus growth and bioactivity of spores were studied. Streptomyces californicus was grown on 13 modified plasterboards under saturated humidity conditions. The total content of fatty acid methyl esters was used for quantifying S. californicus biomass, w... | [
"To examine the effect of previously described bacterial antagonists on the viability of Verticillium microsclerotia in vitro and to elucidate the possible modes of action of bacterial strains in the suppression of Verticillium microsclerotia viability. A microplate assay was developed to test the suppressive effec... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does [ High-dose glucose induce human retinal endothelial cell apoptosis ]? | [
"To examine the direct effect of high glucose levels on primary cultured human retinal capillary endothelial cells (HRCEC). HRCECs were isolated from donated eyes and cultured for 6 days in the media containing 5 or 25 mmol/L glucose. The cell viability was determined by trypan blue exclusion assay and cell cycle a... | [
"What mechanism is involved in regulating the autophagy of endometrial stromal cells (ESCs), and does it participate in the pathogenesis of endometriosis?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does optimization of low pre-operative hemoglobin reduce transfusion requirement in patients undergoing transurethral resection of prostate? | [
"To identify factors that influence peri-operative hemorrhage in view of reducing the need for transfusions in patients undergoing trans uretheral resection of prostate (TURP). All patients undergoing TURP between January 1997 and December 1999 were identified using ICD 9CM coding and indexing system. Overall 430 p... | [
"In this study, we aimed to determine the complications of standard surgical treatments among patients over 75 years in a high-volume urologic center. We analyzed 100 consecutive patients older than 75 years who had undergone transurethral prostatic resection of the prostate or open prostatectomy for treatment of b... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does heparin-coated balloon-expandable stent reduce intimal hyperplasia in the iliac artery in baboons? | [
"To examine the effect of heparin-coated balloon-expandable iliac stent placement on intimal hyperplasia in a baboon model. Balloon-expandable (Palmaz-Schatz) stents were placed in bilateral common iliac arteries in 20 male baboons (mean weight: 8.8 kg). In each animal, a heparin-coated iliac stent was placed on on... | [
"Preclinical evaluation of the vascular response of drug-eluting stents is limited especially in the setting of diabetes mellitus preventing the evaluation of changes in drug-eluting stent design and eluted drugs after clinical use. Cultured human aortic endothelial cells were used to assess the differences between... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are influence of race in heart failure and cardiac transplantation : mortality differences eliminated by specialized , comprehensive care? | [
"Differences in mortality are thought to exist between African Americans and Caucasians with heart failure. These differences may be due to a variety of factors, including differences in disease process, socioeconomic status, and access to health care. Additionally, little data exist on racial differences between t... | [
"Public reporting of procedural outcomes leads to risk averse behavior because physicians do not believe the scores account for patient risk. We investigated the effects of more aggressive percutaneous coronary intervention (PCI) practice on risk-adjusted mortality. 8935 PCI were performed. Risk adjustment was perf... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does lipid emulsion infusion rescue dogs from bupivacaine-induced cardiac toxicity? | [
"We previously demonstrated in rats that intravenous infusion of a lipid emulsion increases survival in resuscitation from severe bupivacaine cardiac toxicity. The present studies were undertaken to determine if this method is similarly effective in a non-rodent model using a larger animal. Bupivacaine, 10 mg/kg, w... | [
"Postresuscitation myocardial dysfunction has been recognized as a leading cause of early death after initial successful resuscitation. Recent experimental and clinical studies have indicated that the beta-adrenergic effect of epinephrine significantly increases the severity of postresuscitation myocardial dysfunct... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.