query stringlengths 17 395 | pos list | neg list | task stringclasses 1
value | instruction dict |
|---|---|---|---|---|
Do low concentrations of transforming growth factor-beta-1 induce tubulogenesis in cultured mammary epithelial cells? | [
"Formation of branching tubes is a fundamental step in the development of glandular organs. To identify extracellular cues that orchestrate epithelial tubulogenesis, we employed an in vitro assay in which EpH4-J3B1A mammary epithelial cells form spheroidal cysts when grown in collagen gels under serum-free conditio... | [
"Pancreatic ductal carcinoma cells induce fibrosis by stimulating pancreatic stellate cells to proliferate and synthesize matrix. Desmoplastic reaction has also been observed in liver metastases of pancreatic carcinoma. Hepatic stellate cells are similar to pancreatic stellate cells and may contribute to the desmop... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does phosphorylation of sodium channels mediated by protein kinase-C modulate inhibition by topiramate of tetrodotoxin-sensitive transient sodium current? | [
"Topiramate is a novel anticonvulsant known to modulate the activity of several ligand- and voltage-gated ion channels in neurons. The mechanism of action of topiramate, at a molecular level, is still unclear, but the phosphorylation state of the channel/receptor seems to be a factor that is able to influence its a... | [
"An epileptic seizure is frequently the presenting sign of intracerebral hemorrhage (ICH) caused by stroke, head trauma, hypertension, and a wide spectrum of disorders. However, the cellular mechanisms responsible for occurrence of seizures during ICH have not been established. During intracerebral bleeding, blood ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are genetic polymorphisms of CYP2C9 and CYP2C19 related to drug-induced idiosyncratic liver injury ( DILI )? | [
"The general view on the pathogenesis of drug-induced idiosyncratic liver injury (DILI) is that parent compounds are rendered hepatotoxic by metabolism, mainly by cytochrome (CYP) 450, although other metabolic pathways can contribute. Anecdotal reports suggest a role of CYP 450 polymorphisms in DILI. We aimed to as... | [
"Coumarin, used in the treatment of chronic venous diseases, is mainly metabolized to non-toxic 7-hydroxy-coumarin by CYP2A6. At least, 3 variant alleles, CYP2A6*2, CYP2A6*3 and CYP2A6*4A, have been shown to encode catalytically defective proteins. Sporadic elevation of liver enzymes has been reported on the chroni... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does intraoperative cholangiography facilitate simple transcystic clearance of ductal stones in units without expertise for laparoscopic bile duct surgery? | [
"In the absence of facilities and expertise for laparoscopic bile duct exploration (LBDE), most patients with suspected ductal calculi undergo preoperative endoscopic duct clearance. Intraoperative cholangiography (IOC) is not performed at the subsequent laparoscopic cholecystectomy. This study aimed to investigate... | [
"Percutaneous biliary drainage is an established alternative to ERCP for managing bile duct obstruction. Although generally safe and effective, percutaneous drainage has its risks and is technically more difficult in patients with nondilated bile ducts. We report the use of nasobiliary drains and subsequent nasobil... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does hypernatremia predict adverse cardiovascular and neurological outcomes after SAH? | [
"Abnormalities of serum sodium are common after subarachnoid hemorrhage (SAH) and have been linked to poor outcome. This study analyzed whether abnormal serum sodium levels are associated with cardiac outcomes and mortality after subarachnoid hemorrhage (SAH). In a prospective cohort study of SAH patients, the prim... | [
"Hundreds of thousands of craniotomies are performed annually in the United States. During craniotomy, elevated serum lactate is a concerning and not infrequent occurrence. Elevated intraoperative serum lactate may occur as a result of global hypoperfusion or localized intracerebral ischemia from surgical retractio... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is a cross-sectional study of self-reported chemical-related sensitivity associated with gene variants of drug-metabolizing enzymes? | [
"N-acetyltransferases (NAT) and glutathione S-transferases (GST) are involved in the metabolism of several ubiquitous chemical substances leading to the activation and detoxification of carcinogenic heterocyclic and aromatic amines. Since polymorphisms within these genes are described to influence the metabolism of... | [
"Adverse drug reactions (ADRs) associated with anti-tuberculosis (anti-TB) drug regimens have considerable impact on anti-TB treatment, potentially leading to unsuccessful outcomes. Nevertheless, the risk factors that play a role in anti-TB drug-induced ADRs are not well established. It is well documented that gene... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does dual blockade of the Hedgehog and ERK1/2 pathways coordinately decrease proliferation and survival of cholangiocarcinoma cells? | [
"The Hedgehog (Hh) and pERK1/2 pathways participate in the tumorigenesis of various tissues, but there has been no report on the involvement of these two pathways in cholangiocarcinoma (CCA). The aim of this study was to evaluate the effects of the Hh pathway inhibitor, cyclopamine, and MEK inhibitor, U0126, as a s... | [
"Fetal hepatic stem/progenitor cells, called hepatoblasts, play central roles in liver organogenesis; however, molecular mechanisms regulating proliferation and terminal differentiation of such cells have not been completely elucidated. Bone morphogenetic protein-4 (BMP-4) is essential for the development of stem c... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver disease? | [
"In nonalcoholic fatty liver disease (NAFLD), increased alanine aminotransferase (ALT) concentrations are considered to be a consequence of hepatocyte damage. We performed a prospective study to examine the association between ALT within its reference interval and risk for subsequent development of NAFLD. The study... | [
"Whether alcohol consumption influences the development of hepatitis C in the presence of a latent infection needs to be determined. The interaction between alcohol intake and hepatitis C virus infection with regard to development of liver injury was cross-sectionally investigated for 399 inhabitants of a town in N... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do chronic rhinosinusitis patients with polyps or polypoid mucosa have a greater burden of illness? | [
"Recent studies suggest chronic rhinosinusitis without nasal polyposis (CRSsNP) and CRS with nasal polyposis (CRScNP) represent distinct pathological entities. The aim of this study was to determine whether patients with CRSsNP, CRScNP, and polypoid CRS could be distinguished by clinical features, radiologic extent... | [
"No guidelines comprise when or to what extent sinus surgery should be done in patients with cystic fibrosis (CF) or how a CT scan of the paranasal sinuses should influence the decision. Symptoms of rhinosinusitis and/or eradication of pathogenic bacteria from the sinuses are reasons for sinus surgery. In this obse... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is plasma aldosterone related to severity of obstructive sleep apnea in subjects with resistant hypertension? | [
"Obstructive sleep apnea (OSA) and primary aldosteronism are common in subjects with resistant hypertension; it is unknown, however, if the two disorders are causally related. This study relates plasma aldosterone and renin levels to OSA severity in subjects with resistant hypertension, and in those with equally se... | [
"Recent data suggest that sleep disorders may be common in patients with end-stage renal disease (ESRD) and patients with pre-dialytic chronic kidney disease (CKD). The prevalence of sleep disorders in CKD, its association to kidney function and related factors is still unclear. This study aimed to measure the prev... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does intensive smoking cessation intervention reduce mortality in high-risk smokers with cardiovascular disease? | [
"To compare an intensive smoking cessation intervention against usual care in hospitalized high-risk smokers with acute cardiovascular disease. A total of 209 hospitalized smokers were randomized to the intensive intervention (n = 109) or to usual care (n = 100). Usual care consisted only of counseling and printed ... | [
"Patients with heart failure often suffer from multiple co-morbid conditions. However, until now only cardiovascular co-morbidity has been well described. To understand heart failure in the context of multi-morbidity, by describing the age and sex specific patterns of non-cardiovascular co-morbidity in elderly pati... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is persistent airway obstruction after virus infection associated with airway inflammation? | [
"This study examined the contribution of airway inflammation to the delayed lung function recovery that occurs in some people following virus-induced asthma exacerbations. Subjects (n = 40) were recruited at hospital admission for acute asthma exacerbation. Respiratory virus infection was diagnosed by viral nucleic... | [
"Respiratory syncytial virus (RSV) is the most common cause of acute bronchiolitis in infants and the elderly. Furthermore, epidemiological data suggest that RSV infection during infancy is a potent trigger of subsequent wheeze and asthma development. However, the mechanism by which RSV contributes to asthma is com... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is use of modern contraception by the poor falling behind? | [
"The widespread increase in the use of contraception, due to multiple factors including improved access to modern contraception, is one of the most dramatic social transformations of the past fifty years. This study explores whether the global progress in the use of modern contraceptives has also benefited the poor... | [
"What are the lifestyle choices and dietary aspects of women about to undergo fertility treatment in New Zealand?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does best lead in the standard electrocardiogram for the emergency detection of acute coronary syndrome? | [
"The purpose of this study was to determine which leads in the standard 12-lead electrocardiogram (ECG) are the best for detecting acute coronary syndrome (ACS) among chest pain patients in the emergency department. Neural network classifiers were used to determine the predictive capability of individual leads and ... | [
"Coronary artery bypass graft is often the treatment of choice for patients who suffer from unstable angina. We do not know whether this condition adds morbidity in this scenario. To compare the outcomes of patients undergoing coronary artery bypass graft with unstable angina framework with patients who underwent c... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is sinonasal epithelial cell expression of toll-like receptor 9 decreased in chronic rhinosinusitis with polyps? | [
"Innate immune recognition of pathogens by sinonasal epithelial cells may play an important role in the pathogenesis of chronic rhinosinusitis (CRS). Previous studies have indicated that toll-like receptor (TLR) mRNA is present in sinonasal mucosa, and levels of TLR9 expression are decreased in recalcitrant CRS wit... | [
"Indoleamine 2,3 dioxygenase (IDO), the key metabolic enzyme implicated in tryptophan catabolism has been studied extensively during the past years in cancer, infections and autoimmunity. This review summarizes the findings of the immunomodulatory effects of IDO. In addition, the possible role of IDO in chronic rhi... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does parental smoking impair vaccine responses in children with atopic genotypes? | [
"Gene-environment interactions play central roles in controlling postnatal maturation of immune function, but their effects on infant vaccine responses are unknown. Genetic variants associated with atopy and the environmental factor of exposure to parental smoking (PS) of tobacco independently alter immune response... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does oral administration of tetrahydrobiopterin slow the progression of atherosclerosis in apolipoprotein E-knockout mice? | [
"Although it has been reported that oral administration of tetrahydrobiopterin (BH4) prevents endothelial dysfunction and vascular oxidative stress in various rat models, the effect of treatment with BH4 on atherogenesis remains unclear. In this study, we investigated whether oral BH4 treatment might slow the progr... | [
"Cigarette smoking is an independent risk factor for atherosclerosis. Nicotine, the addictive component of cigarettes, induces mast cell (MC) release and contributes to atherogenesis. The purpose of this study was to determine whether nicotine accelerates atherosclerosis through MC-mediated mechanisms and whether M... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does site of arterial occlusion identified by transcranial Doppler predict the response to intravenous thrombolysis for stroke? | [
"The objective of this study was to examine clinical outcomes and recanalization rates in a multicenter cohort of stroke patients receiving intravenous tissue plasminogen activator by site of occlusion localized with bedside transcranial Doppler. Angiographic studies with intraarterial thrombolysis suggest more pro... | [
"Thromboembolic stroke is the most common severe complication following coil embolization of intracerebral aneurysms, with a 5% incidence of permanent deficits. Despite heparin anticoagulation, rescue therapy with the platelet glycoprotein IIb/IIIa receptor antagonist abciximab may be required. However, we describe... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does prevalence and correlate of binge eating disorder in a community sample? | [
"Diagnostic criteria for binge eating disorder (BED) appear in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition as \"criteria for further study.\" Few epidemiological studies of BED have been conducted. Our aim was to describe the prevalence and correlates of BED, as assessed by the Patient Hea... | [
"Problematic Internet use or excessive Internet use is characterized by excessive or poorly controlled preoccupations, urges, or behaviors regarding computer use, and Internet access that leads to impairment or distress. Cross-sectional studies on samples of patients reported high comorbidity of Internet addiction ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are proinflammatory macrophage migratory inhibition factor and interleukin-6 concentrated in pleural effusion of human fetuses with prenatal chylothorax? | [
"To study the role of selected cytokines and growth factors involved in the pathogenesis of fetal chylous pleural effusion. Seventeen fetuses with prenatal chylothorax at gestational age (GA) 17-29 weeks were enrolled as the study group during the period 2003-2005. Their pleural effusion (n = 17) and amniotic fluid... | [
"Inflammation plays a critical role in lung disease development and progression in cystic fibrosis. Azithromycin is used for the treatment of cystic fibrosis lung disease, although its mechanisms of action are poorly understood. We tested the hypothesis that azithromycin modulates lung inflammation in cystic fibros... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does evaluation of quantitative magnetic resonance imaging contrast in MRI-negative refractory focal epilepsy? | [
"Conventional optimal MRI is unremarkable in 20%-30% of patients with intractable focal epilepsy. These MRI-negative patients are the most challenging in surgical programs. Our aim was to evaluate the yield and utility of quantitative MRI with novel contrasts in MRI-negative patients with refractory focal epilepsy,... | [
"Anti-N-methyl-d-aspartate receptor (anti-NMDAR) autoimmune encephalitis is an increasingly recognized cause of limbic encephalitis (LE). Prolonged LE and limbic status epilepticus (LSE) share many features. The ability to distinguish between the two is crucial in directing appropriate therapy because of the potent... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does expression of the Longin domain of TI-VAMP impair lysosomal secretion and epithelial cell migration? | [
"TI-VAMP (tetanus neurotoxin-insensitive vesicle-associated membrane protein; also called VAMP7) belongs to the Longin subfamily of v-SNAREs (vesicular soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors). The regulatory N-terminal extension, called the Longin domain, of TI-VAMP has been ... | [
"Choroideremia (CHM) is an X-linked progressive degeneration of the retinal pigment epithelium (RPE), photoreceptors, and choroid caused by mutations in the CHM gene, which encodes Rab escort-protein-1 (REP-1). REP-1 enables posttranslational isoprenyl modification of Rab GTPases, proteins that control vesicle form... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is hypercalcaemia associated with poor mental health in haemodialysis patients : results from Japan DOPPS? | [
"The Dialysis Outcomes and Practice Patterns Study (DOPPS) reported high incidence of depression in haemodialysis patients. Hypercalcaemia and high parathyroid hormone (PTH) levels are aetiological factors of psychological disorders. We examined the association between mineral metabolism abnormalities and mental he... | [
"Recent data suggest that sleep disorders may be common in patients with end-stage renal disease (ESRD) and patients with pre-dialytic chronic kidney disease (CKD). The prevalence of sleep disorders in CKD, its association to kidney function and related factors is still unclear. This study aimed to measure the prev... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does levels and correlate of exercise in a border mexican american population? | [
"To examine personal and environmental correlates of exercise among Mexican Americans living in the Texas-Mexico border region. The study was based on data from a community health assessment conducted in 2 counties at the Texas-Mexico border region. A random-digit-dialed community survey was used in this cross-sect... | [
"In order to definitude the influence caused by the different sampling in voice assessment. We comparing the results acquired by total section and subsection sampling. The results acquired by subsection tended to normal more than those acquired by total section."
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do platinum group elements enhance the allergic immune response by acting on dendritic cells? | [
"Atmospheric pollution may play a role in the immune response to allergens either directly or by entering the food chain. While particulate platinum group elements (PLGE) emitted by catalytic converters can be considered biologically inert, approximately 10% of these species accumulate in the environment as bioavai... | [
"To discuss the presence and role of neutrophils in asthma and allergic diseases, and outline the importance of pollen and cat dander-induced innate neutrophil recruitment in induction of allergic sensitization and allergic inflammation. Uncontrolled asthma is associated with elevated numbers of neutrophils, and le... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does stimulation of the nitric oxide/cyclic guanosine monophosphate signaling pathway elicit human sperm chemotaxis in vitro? | [
"To investigate whether nitric oxide (NO) may attract human spermatozoa via activation of the soluble guanylate cyclase (sGC)/cyclic guanosine monophosphate (cGMP) pathway. Prospective study. Academic research institution. Seven normozoospermic patients belonging to couples presenting for infertility evaluation. Sp... | [
"Propofol may have beneficial effects on the prevention of angiotensin II (Ang II)-induced cardiac fibroblast proliferation via its antioxidative properties. The authors hypothesized that propofol may alter Ang II-induced cell proliferation and aimed to identify the putative underlying signaling pathways in rat car... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are ovarian dysgerminomas characterised by frequent KIT mutations and abundant expression of pluripotency markers? | [
"Ovarian germ cell tumours (OGCTs) typically arise in young females and their pathogenesis remains poorly understood. We investigated the origin of malignant OGCTs and underlying molecular events in the development of the various histological subtypes of this neoplasia. We examined in situ expression of stem cell-r... | [
"Fibrolamellar hepatocellular carcinoma (FLC) is a rare subtype of liver cancer occurring mostly in children and young adults. We have shown that FLC comprises two separate entities: pure (p-FLC) and mixed-FLC (m-FLC), differing in clinical presentation and course. We show that p-FLCs have a distinct gene expressio... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are negative inotropic effects of tumour necrosis factor-alpha and interleukin-1beta ameliorated by alfentanil in rat ventricular myocytes? | [
"Serum levels of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) increase during an inflammatory response and have been reported to induce a negative inotropic effect on the myocardium. Alfentanil, an opioid analgesic often used in the critical care of patients with sepsis, has been shown ... | [
"The role of the nitric oxide/cGMP/cGMP-dependent protein kinase G pathway in myocardial protection and preconditioning has been the object of intensive investigations. The novel soluble guanylate cyclase activator cinaciguat has been reported to elevate intracellular [cGMP] and activate the nitric oxide/cGMP/cGMP-... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does [ Killer cell immunoglobulin receptor play an important role in cord blood transplantation for leukemia ]? | [
"To investigate the role of killer cell immunoglobulin receptor (KIR) plays in treatment of leukemia by cord blood transplantation (CBT). Peripheral blood samples were collected from 23 patients receiving CBT, and corresponding cord blood samples were collected too. Polymerase chain reaction with sequence-specific ... | [
"What mechanism is involved in regulating the autophagy of endometrial stromal cells (ESCs), and does it participate in the pathogenesis of endometriosis?"
] | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does a novel inhibitor of inflammatory cytokine production ( CNI-1493 ) reduce rodent post-hemorrhagic vasospasm? | [
"Cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is a devastating complication, yet despite multiple lines of investigation an effective treatment remains lacking. Cytokine-mediated inflammation has been implicated as a causative factor in the development of posthemorrhagic vasospasm. In previous ... | [
"Neuronal injury in pneumococcal meningitis is a consequence of microglial activation and direct toxicity by bacterial products and systemic inflammation. The treatment effect of the TEPC-15 antibody recognizing teichoic and lipoteichoic acids was investigated in murine microglial cells and in a rabbit model of pne... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does [ New compound heterozygous mutation cause partial combined 17 alpha-hydroxylase/17,20-lyase deficiency ]? | [
"To investigate the CYP17A1 gene mutations in a Chinese 46,XX patient with partial combined 17 alpha-hydroxylase/17,20-lyase deficiency. Clinical data were retrospectively analyzed. The genomic DNA of the patient and her parents was isolated from whole blood. Seven pairs of primers were used to amplify eight exons ... | [
"Two boys presenting with infection-triggered, life-threatening salt-loss and hyperkalaemia were published in 1991 in the European Journal of Pediatrics. In both boys, the diagnosis of corticosterone methyl oxidase (CMO) deficiency type II has been established on the basis of determinations of plasma and urinary st... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does granulocyte-macrophage colony-stimulating factor ( GM-CSF ) restore decreased monocyte HLA-DR expression after cardiopulmonary bypass? | [
"Cardiopulmonary bypass (CPB) is associated with a disturbed immune response, e.g., impaired HLA-DR expression on monocytes and the release of pro- and anti-inflammatory cytokines. Cytokine release plays a role in the pathogenesis of postoperative systemic inflammatory response syndrome (SIRS) and immune system det... | [
"The autonomic storm accompanying brain death leads to neurogenic pulmonary edema and triggers development of systemic and pulmonary inflammatory responses. Neurogenic vasoplegia exacerbates the pulmonary injury caused by brain death and primes the lung for ischemia reperfusion injury and primary graft dysfunction ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is impaired natural killer cell lysis in breast cancer patients with high levels of psychological stress associated with altered expression of killer immunoglobin-like receptors? | [
"We previously reported that cancer-related psychological stress is associated with reduced natural killer (NK) cell lysis. We hypothesized that reduced NK cell cytotoxicity in patients with increased levels of stress would correlate with alterations in the expression of inhibitory NK cell receptors (killer immunog... | [
"Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) leads to liver fibrosis. Here, we postulated that the immune regulatory properties of HSCs might promote the profibrogenic activity of B cells. Fibrosis is completely attenuated in carbon tetrachloride-treated, B cell-deficient µMT mice,... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is [ X-chromosomal inactivation skewing in blood cells associated with early development of lung ]? | [
"To observe the relationship between skewed X-chromosomal inactivation (SXCI) and development of lung cancer in females. DNA was isolated from peripheral blood cells from patients with primary lung cancer (n = 148) and control subjects (n =289). Exon 1 of androgen receptor ( AR) gene was amplified, with its product... | [
"The recessive X-linked disorder hemophilia A (HA) is rarely expressed in female carriers, most of whom express about half of normal factor VIII activity ( C). To propose an integrative assessment model for the binary role of the phase between the mutated F8 and the active X-chromosome (Xa) in C in HA carriers. We ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is hypermethylation of the CpG islands in the promoter region flanking GSTP1 gene a potential plasma DNA biomarker for detecting prostate carcinoma? | [
"To investigate the possibility of identifying DNA hypermethylation in the circulation of prostate cancer patients. Plasma DNA samples were extracted from 36 prostate cancer patients and 27 benign prostate hyperplasia (BPH) cases. After extensive methylation-sensitive restriction enzyme digestion, the DNA samples w... | [
"Methylthioadenosine phosphorylase (MTAP) is an essential enzyme for the methionine and adenosine salvage pathway in normal cells, frequently inactivated in many different human cancers. MTAP status could be important for tumour cell sensitivity to adjuvant chemotherapy. To our knowledge, there have been no reports... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does nitric oxide fail to confer endogenous antiarrhythmic cardioprotection in the primate heart in vitro? | [
"The role of nitric oxide (NO) in cardiac pathophysiology remains controversial. According to data from several studies using rat and rabbit isolated hearts, NO is an endogenous cardioprotectant against reperfusion-induced ventricular fibrillation (VF). Thus, if cardiac NO production is abolished by perfusion with ... | [
"Myocardial reperfusion via the re-canalization of occluded coronary arteries is gold standard for the treatment of acute myocardial infarction. However, reperfusion itself can cause myocardial damage due to increased reactive oxygen species (ROS) production, a process known as ischemia/reperfusion (I/R) injury. Ca... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does multiplex ligation-dependent probe amplification detect DCX gene deletions in band heterotopia? | [
"Subcortical band heterotopia (SBH, or double cortex syndrome) is a neuronal migration disorder consisting of heterotopic bands of gray matter located between the cortex and the ventricular surface, with or without concomitant pachygyria. Most cases show diffuse or anteriorly predominant (A>P) migration abnormality... | [
"Pulmonary capillary hemangiomatosis (PCH) is an uncommon pulmonary disorder, with variable clinical features depending on which lung structure is affected, and it is usually linked to pulmonary arterial hypertension. Congenital PCH has been very rarely described and, so far, the only causative gene identified is E... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does hyperleptinaemia and chronic inflammation after peritonitis predict poor nutritional status and mortality in patients on peritoneal dialysis? | [
"The serum leptin level is elevated in patients undergoing peritoneal dialysis (PD) and associated with a loss of lean body mass. The nutritional status of PD patients may further be worsened following peritonitis. We investigated the association between hyperleptinaemia, inflammation and malnourishment in PD-relat... | [
"Prolonged length of stay in intensive care units after congenital heart disease surgery is associated with poor outcome, places a considerable burden on the financial resources of hospitals, and is an organizational challenge as well. This research discusses the impact of perioperative factors on prolonged stay in... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does lower red blood cell folate enhance the HPV-16-associated risk of cervical intraepithelial neoplasia? | [
"We previously reported that higher circulating concentrations of folate are independently associated with a lower likelihood of becoming positive for high-risk human papillomaviruses (HR-HPVs) and of having a persistent HR-HPV infection and a greater likelihood of becoming HR-HPV negative (Cancer Res 2004;64:8788-... | [
"Cervical cancer development from a squamous intraepithelial lesion is thought to be favored by an impaired T cell immunity. We evaluated parameters of T cell alterations such as proliferation, cytokine, and CD3zeta expression in peripheral blood and tumor-infiltrating T lymphocytes from women with squamous intraep... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is severe reflux disease associated with an enlarged unbuffered proximal gastric acid pocket? | [
"An unbuffered pocket of highly acidic juice is observed at the gastric cardia after a meal in healthy subjects. To compare the postprandial acid pocket in healthy subjects and patients with severe reflux disease and define its position relative to anatomical and manometric landmarks. 12 healthy subjects and 16 pat... | [
"Gastroesophageal reflux and progressive esophageal dilatation can develop after gastric banding (GB). Gastric banding may interfere with esophageal motility, enhance reflux, or promote esophageal dilatation. Before-after trial in patients undergoing GB. University teaching hospital. Between January 1999 and August... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does chimeric DNA-RNA hammerhead ribozyme targeting transforming growth factor-beta1 mRNA ameliorate renal injury in hypertensive rats? | [
"Transforming growth factor (TGF)-beta is a critical factor in the progression of renal injury, regardless of the primary etiology. Such injury is characterized by glomerular sclerosis and tubulointerstitial fibrosis. To develop a ribozyme-based therapy for progressive renal diseases, we examined the effects of chi... | [
"Hypoxia inducible factor l is a heterodimeric transcription factor that plays an important role in oxygen homeostasis. A good body of evidence indicates that overexpression of HIF-1alpha driven by intratumoral hypoxia can transactivate genes essential for energy metabolism, erythropoiesis, and vascular development... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does perindopril-based blood pressure-lowering therapy reduce amino-terminal-pro-B-type natriuretic peptide in individuals with cerebrovascular disease? | [
"The plasma amino-terminal-pro-B-type natriuretic peptide (NT-proBNP) level predicted congestive heart failure, myocardial infarction, and ischaemic stroke in participants of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS), a placebo-controlled study of the effects of blood pressure lowering on... | [
"Left ventricular abnormalities contribute to cardiovascular disease in patients with chronic kidney disease and may be detected by measurement of B-type natriuretic peptide in serum. In a prospective cohort study of predialysis patients, patients who were on dialysis, and kidney transplant recipients, serum was co... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do technical modifications in endoscopic vein harvest techniques facilitate their use in lower extremity limb salvage procedures? | [
"We describe and report our results using endoscopic vein harvest (EVH) for lower extremity arterial bypass procedures, following the implementation of technical modifications specific to patients undergoing limb salvage procedures. We underwent training in EVH, followed by implementation of the technique in patien... | [
"Statins are an essential component of the therapeutic approach of patients with atherosclerotic disease. Statin use is also associated with improved peri-operative and long-term outcomes in these patients. We aimed to define the role of statin treatment in patients undergoing percutaneous revascularization procedu... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer 's disease? | [
"Inflammation has been extensively implicated in the pathogenesis of Alzheimer's disease (AD). Although there is evidence of a key role for cytokines in neuroinflammation processes, so far the proinflammatory cytokine interleukin (IL)-18 has not been associated with AD. The aim of this study was to investigate the ... | [
"Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by loss of motor neurons in the brainstem, motor cortex, and spinal cord. Oxidative stress and neuroinflammation have been implicated in the pathophysiology of ALS. Members of the family of damage-associated molecular patt... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does cholinesterase inhibitor use significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer 's disease from dementia with Lewy bodies? | [
"123I-labelled 2beta-carbomethoxy-3beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-CIT) imaging is a diagnostic tool to help differentiate dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). However, in animals, cholinesterase inhibitors (ChEi) have been reported to reduce radioligand binding ... | [
"Differential diagnosis of parkinsonian disorders is challenging because of overlapping symptoms, especially during early stages of disease. No validated biomarkers are available for early and accurate diagnosis of multiple system atrophy and other parkinsonian disorders. It has been reported that flt3 ligand level... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do [ Cryotherapy combine with pingyangmycin for the treatment of venous malformations ]? | [
"To observe the therapeutic effect of 120 cases venous malformations treated by cryotherapy combine with pingyangmycin. Pingyangmycin was injected into venous malformations and cryotherapy with liquid nitrogen was followed immediately. Cure rate was 77.5%, incomplete cure rate was 17.5% and efficiency rate was 5%."... | [
"To discuss the application scope of Sini capsule in treationg coronary heart disease angina. Different syndrome of coronary heart disease angina was treated with the same Sini Capsule, and the change of angina, electrocardiogram and cardiac function was observed. Sini capsule could evidently decrease angina outbre... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does a temporary intraurethral prostatic stent relieve prostatic obstruction following transurethral microwave thermotherapy? | [
"The Spanner, a novel prostatic stent, was evaluated for safety, efficacy and patient tolerance when used to relieve prostatic obstruction following transurethral microwave thermotherapy. Following transurethral microwave thermotherapy and routine post-procedure Foley catheterization at 1 of 9 clinical sites 186 pa... | [
"In this study, we aimed to determine the complications of standard surgical treatments among patients over 75 years in a high-volume urologic center. We analyzed 100 consecutive patients older than 75 years who had undergone transurethral prostatic resection of the prostate or open prostatectomy for treatment of b... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are serum anti-mullerian hormone concentrations altered by acute administration of follicle stimulating hormone in polycystic ovary syndrome and normal women? | [
"In the human ovary, expression of anti-Mullerian hormone (AMH) is detected primarily in granulosa cells of preantral and small antral follicles. This finding is consistent with the tight correlation between circulating AMH levels and the number of small antral follicles (2-5 mm) in normal and polycystic ovary synd... | [
"To determine the effect of a spontaneous luteinizing hormone (LH) surge on the cycle fecundity during superovulation induction. Superovulatory cycles of patients with various diagnoses are retrospectively compared. Reproductive Endocrinology Outpatient Clinic. A total of 1,185 superovulatory cycles from July 1, 19... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are lipoprotein ( a ) and LDL particle size related to the severity of coronary artery disease? | [
"The pathophysiological role and metabolic pathway of Lp(a) have not been clearly defined. An association between Lp(a) and oxidative low-density lipoprotein (LDL) were recently reported. And small dense LDL (sd-LDL) were associated with circulating malondialdehyde-modified LDL. We investigated the relationships be... | [
"Indoxyl sulfate (IS) is linked to endothelial damage, NF-κB activation and induced development of atherosclerosis. The purpose of this study was to investigate the relationship between serum IS levels and the severity of coronary artery stenosis. In addition, the relationship among IS and various cardiovascular ri... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does the role of amiodarone in recent-onset atrial fibrillation after ibutilide have failed to restore sinus rhythm? | [
"Ibutilide is a class III antiarrhythmic drug that is used for the cardioversion of atrial arrhythmias, but it can cause torsades de pointes. Amiodarone is also used for the cardioversion of atrial fibrillation and prolongs the QT interval but rarely causes torsades de pointes. The study included 51 consecutive pat... | [
"The purpose of this report was to study heart rate variability in Holter recordings of patients who experienced ventricular fibrillation during the recording. Decreased heart rate variability is recognized as a long-term predictor of overall and arrhythmic death after myocardial infarction. It was therefore postul... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is elevated C-reactive protein in acute coronary syndrome presentation an independent predictor of long-term mortality and heart failure? | [
"To assess the ability of C-reactive protein (CRP) to predict long-term outcomes in a chest pain population. CRP was measured at presentation in 446 emergency department patients with acute coronary syndromes. All-cause mortality and hospital discharges for acute myocardial infarction (AMI) and congestive heart fai... | [
"The purpose of this study was to examine the impact of sulfonylurea drug use on outcome in diabetic patients undergoing direct coronary angioplasty for acute myocardial infarction. Sulfonylurea drugs impair ischemic preconditioning. Whether sulfonylurea drugs affect outcome adversely in diabetic patients undergoin... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does intermittent hypoxia cause insulin resistance in lean mice independent of autonomic activity? | [
"Although many clinical physiology and epidemiology studies show an association between obstructive sleep apnea (OSA) and markers of insulin resistance, no causal pathway has been established. The purpose of the current study was to determine if the intermittent hypoxia (IH) stimulus that characterizes OSA causes i... | [
"Patients with obstructive sleep apnea are often overweight or obese, and they frequently exhibit metabolic aberrations, collectively known as the metabolic syndrome, an established cardiovascular risk factor. We review recent data on the relationship between obstructive sleep apnea and metabolic syndrome or its co... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma? | [
"Airway hyperresponsiveness (AHR) increases up to 2 weeks after allergen inhalational challenge of subjects with asthma who show a late-phase asthmatic reaction (dual responders). Cellular inflammation and airway remodeling are increased 24 hours after allergen challenge. To determine whether persistence of increas... | [
"Offspring of asthmatic mothers have increased risk of developing asthma, based on human epidemiologic data and experimental animal models. The objective of this study was to determine whether maternal allergy at non-pulmonary sites can increase asthma risk in offspring. BALB/c female mice received 2 topical applic... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is calcification of human articular knee cartilage primarily an effect of aging rather than osteoarthritis? | [
"Pathologic calcification of articular cartilage in human knees is often associated with advanced age and conditions of osteoarthritis (OA). Coincidently, most studies that have characterized calcification in joint cartilage have examined populations that are aged and presenting with clinical symptoms. Generally, t... | [
"Osteoarthritis (OA) is a serious disease of the entire joint, characterized by articular cartilage degeneration, subchondral bone changes, osteophyte formation, and synovial hyperplasia. Currently, there are no pharmaceutical treatments that can slow the disease progression, resulting in greatly reduced quality of... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do single nucleotide polymorphisms ( SNPs ) distinguish Indian-origin and Chinese-origin rhesus macaques ( Macaca mulatta )? | [
"Rhesus macaques serve a critical role in the study of human biomedical research. While both Indian and Chinese rhesus macaques are commonly used, genetic differences between these two subspecies affect aspects of their behavior and physiology, including response to simian immunodeficiency virus (SIV) infection. Si... | [
"To investigate whether different mitochondrial DNA (mtDNA) haplogroups have a role on the development of pseudoexfoliation glaucoma (PEG) in the Saudi Arab population. The mtDNA regulatory region and coding regions comprising mtDNA haplogroup diagnostic polymorphisms were sequenced in patients with PEG (n=94), hea... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do jEG-3 cell culture supernatants cause reduced interferon-gamma and interleukin-17 production in mixed-lymphocyte reactions? | [
"Immunoregulatory effects of choriocarcinoma-derived factors on leukocytes have been documented. The present study was designed to investigate the effect of JEG-3 culture supernatants on interferon-gamma (IFN-gamma), interleukin-17 (IL-17) and IL-1beta production in the mixed lymphocyte reactions (MLRs). A human ch... | [
"Natural medicines derived from plants are drawing more and more interest in the prevention and treatment of diseases because of their unique characteristics, which include having fewer adverse effects and being more suitable for long-term use compared with synthesized chemicals. To explore the potentially health-p... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is hemodynamic steroid responsiveness predictive of neurological outcome after traumatic brain injury? | [
"To determine the impact of physiologic doses of hydrocortisone on neurologic outcome after traumatic brain injury (TBI). We conducted a retrospective study in a neurocritical care unit at a university teaching hospital. We included 29 patients with moderate and severe TBI requiring vasoactive drugs to maintain ade... | [
"Is there a non-invasive biomarker for the diagnosis of testicular inflammatory lesions?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does donor dopamine pretreatment inhibit tubulitis in renal allografts subjected to prolonged cold preservation? | [
"In the present study, we used the Brown-Norway (BN) to Lewis model as a model for acute rejection, to test the hypothesis that dopamine (DA) treatment of BN donors significantly reduces the inflammatory response after renal transplantation. BN and Lewis rats (isograft controls) were treated for 24 hr with DA (5 mi... | [
"In contrast with kidneys, transplantation of livers originating from non-heart-beating donors remains rare, mainly because warm ischemia causes a higher rate of potentially lethal primary graft nonfunction. Little is known on the tolerance of liver grafts to warm ischemia. No techniques are available to assess the... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does long-term pharmacological activation of PPARgamma prevent left ventricular remodeling in dogs with advanced heart failure? | [
"Peroxisome proliferator-activated receptor gamma (PPARgamma) activators affect the myocardium through inhibition of inflammatory cytokines and metabolic modulation but their effect in the progression of heart failure is unclear. In the present study, we examined the effects of the PPARgamma activator, GW347845 (GW... | [
"Numerous studies have proposed that glycogen synthase kinase (GSK)-3beta is a central regulator of the hypertrophic response of cardiomyocytes. However, all of this work has relied on overexpression of GSK-3beta, expression of constitutively active mutants, or small molecule inhibitors with documented off-target e... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do alcohol cues increase cognitive impulsivity in individuals with alcoholism? | [
"Individuals with alcoholism are characterized by both attentional bias for alcohol cues and prepotent response inhibition deficit. We tested the hypothesis that alcoholics exhibit greater cognitive disinhibition when the response to be suppressed is associated with alcohol-related information. Forty recently detox... | [
"Problem gambling has been proposed to represent a 'behavioural addiction' that may provide key insights into vulnerability mechanisms underlying addiction in brains that are not affected by the damaging effects of drugs. Our aim was to investigate the neurocognitive profile of problem gambling in comparison with a... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does cytochrome P450 2C19 polymorphism influence the preventive effect of lansoprazole on the recurrence of erosive reflux esophagitis? | [
"The efficacy of lansoprazole (LPZ) at inhibiting gastric acid secretion is influenced by cytochrome P450 2C19 (CYP2C19) polymorphism. The purpose of the present study was to investigate whether CYP2C19 polymorphism had an influence on the remission of erosive reflux esophagitis (RE) during maintenance therapy with... | [
"Helicobacter pylori and nonsteroidal antiinflammatory drugs (NSAIDs) are the major causes of gastroduodenal ulcers. Studies on the benefit of eradication of H. pylori in NSAID users yielded conflicting results. To investigate whether H. pylori eradication in patients on long-term NSAIDs reduces the incidence of ga... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is gABRA6 genetic polymorphism associated with the risk of functional heartburn in Chinese? | [
"Polymorphisms of GABA(A)alpha6 (GABRA6)-1521 and IL-1beta-511 have been linked with susceptibility to stress and gastric acid secretion. The aim of this study was to assess psychiatric profiles and GABRA6 and IL-1beta genotypes in functional heartburn, an important esophageal reflux condition. Psychological sympto... | [
"Brain-derived neurotrophic factor (BDNF) is a modulator of synaptic and neural plasticity. Considering the association between dystonia and abnormal sensorimotor cortex plasticity, BDNF may be a candidate gene that confers susceptibility to dystonia. However, the association between Val66Met polymorphism of BDNF g... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are alterations of glutathione S-transferase and matrix metalloproteinase-9 expressions early events in esophageal carcinogenesis? | [
"To investigate the role of glutathione S-transferase (GST) and matrix metalloproteinase-9 (MMP-9) expressions in the development and progression of reflux esophagitis-Barrett's metaplasia-dysplasia-adenocarcinoma sequence in the esophagus. GST and MMP-9 expressions were analyzed in 51 paraffin-embedded tissue samp... | [
"The dose-cumulative cardiotoxicities and the emerging cancerous apoptotic/drug resistance are two major obstacles limiting the efficacy of anthracycline antibiotics, notably doxorubicin. We attempted to prove if schisandrin B (Sch B), a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does american Brachytherapy Society recommend no change for prostate permanent implant dose prescriptions using iodine-125 or palladium-103? | [
"In 2004, the American Association of Physicists in Medicine (AAPM) issued a report outlining recommended 125I and 103Pd datasets for consistency in calculating brachytherapy dose distributions. In 2005, to aid evaluating the clinical impact of implementing these datasets, the AAPM assessed the historical dependenc... | [
"To evaluate the lung and pelvic seed migration and intraprostatic dose variability for prostate seed implant (PSI) using bio-absorbable polymer \"coated\" seeds for intraoperative planning. A total of 100 PSI patients were initially implanted with uncoated I-125 (STM 1251 or I125-SL, N = 85) or Pd-103 (mod 200, N ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do trajectories of adolescent alcohol and cannabis use into young adulthood? | [
"Both alcohol and cannabis use carry health risks. Both are commonly initiated in adolescence. To date little research has described trajectories of adolescent cannabis or alcohol use or compared their respective consequences in young adulthood. The design was a 10-year eight-wave cohort study of a state-wide commu... | [
"Abuse of inhalants containing the volatile solvent toluene is a significant public health issue, especially for adolescent and Indigenous communities. Adolescent inhalant abuse can lead to chronic health issues and may initiate a trajectory towards further drug use. Identification of at-risk individuals is difficu... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is in-room display of day and time patient anticipated to leave hospital : a `` discharge appointment ''? | [
"We learned from a focus group that many patients find discharge to be one of the least satisfying elements of the hospital experience. Patients cited insufficient communication about the day and time of the impending discharge as a cause of dissatisfaction. In partnership with the Institute for Healthcare Improvem... | [
"To design an excel form which can prompt dental implant patient appointment through color change, which can scientifically manage implant EMR library through appropriate interlinkage and number. An excel form based on operating system Windows XP was designed and software 2003 Microsoft excel was used, which was co... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Are serum adiponectin levels , insulin resistance , and lipid profile in children born small for gestational age affected by the severity of growth retardation at birth? | [
"Insulin resistance has been linked to intrauterine growth retardation (IUGR); adiponectin is a protein with insulin-sensitizing properties. This study was designed to test whether being born small for gestational age (SGA) has an effect on blood levels of adiponectin and leptin, insulin resistance parameters, and ... | [
"To examine the effect of maternal smoking on the relationship between maternal hemoglobin levels and pregnancy outcome. A prospective study of healthy parous women from early pregnancy and of their infants. Three Scandinavian university hospitals covering all deliveries from well defined geographical areas. Smokin... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does [ Suicidal cancer vaccine enhance anti-tumor immunotherapeutic effect and its safety in the treatment of ovarian cancer ]? | [
"To study the anti-tumor immunotherapeutic effect induced by the suicidalcancer vaccine FC/TK, and to evaluate the safety of this vaccine. The suicidal cancer vaccine, named FC/TK, was prepared by fusion of suicide gene (HSVI,-TK gene) -modified ovarian carcinoma NuTu-19 cells with rat bone marrow-derived dendritic... | [
"Traditional Chinese Medicine (TCM) has been increasingly used to treat cancers. Trametes robiniophila Murr. (Huaier) is a medicinal fungus for treatment of inflammation and cancer. Huaier Granule has great clinical effect in various types of cancers, including liver cancer, lung cancer, gastric cancer, and breast ... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is [ Ad hTRP2 - mediated immunity against melanoma enhanced by dendritic cells pulsed with peptide ]? | [
"To investigate the enhanced effect of bone marrow-derived dendritic cells (DC) pulsed with SVYDFFVWL, a MHC class I peptide located in 180-188 amino acid residues of human melanoma-associated antigen tyrosinase- related protein 2 ( hTRP2) on the immunity against melanomas elicited by adenovirus encoding hTRP2 (Ad ... | [
"A synthetic peptide corresponding to residues 75-84 of HLA-B2702 modulates immune responses in rodents and humans both in vitro and in vivo. We used a yeast two-hybrid screening, an in vitro biochemical method, and an in vivo animal model. Two cellular receptors for this novel immunomodulatory peptide were identif... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does r-Etodolac decrease beta-catenin levels along with survival and proliferation of hepatoma cells? | [
"Inhibition of hepatoma cells by cyclooxygenase (COX)-2-dependent and -independent mechanisms has been shown previously. Here, we examine the effect of Celecoxib, a COX-2-inhibitor and R-Etodolac, an enantiomer of the nonsteroidal anti-inflammatory drug Etodolac, which lacks COX-inhibitory activity, on the Wnt/beta... | [
"Because neurotransmitter dopamine inhibits vascular permeability factor/vascular endothelial growth factor (VEGF)-induced angiogenesis and as anti-VEGF agents act synergistically with anticancer drugs, we therefore investigated whether dopamine can increase the efficacies of these drugs. The effect of dopamine was... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do comparison of serum folate species analyzed by LC-MS/MS with total folate measured by microbiologic assay and Bio-Rad radioassay? | [
"The Bio-Rad QuantaPhase II radioassay (BR), used for 25 years to measure total folate (TFOL) concentrations for the National Health and Nutrition Examination Survey (NHANES), will be discontinued in 2007. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) or a microbiologic assay (MA) will be used in the fu... | [
"Vitamin D deficiency is an important concern in clinical settings and recently, international agencies have recognised the importance of 25-OHD assays in defining vitamin D status. Thus, our aim was to assess the consistency of different vitamin D assays in clinical practice. 25-OH-vitamin D was measured in 332 pa... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are two-dimensional tracking and TDI consistent methods for evaluating myocardial longitudinal peak strain in left and right ventricle basal segments in athletes? | [
"Myocardial contractility can be investigated using longitudinal peak strain. It can be calculated using the Doppler-derived TDI method and the non-Doppler method based on tissue tracking on B-mode images. Both are validated and show good reproducibility, but no comparative analysis of their results has yet been co... | [
"Hypertrophic cardiomyopathy (HCM) is associated with considerable phenotypic heterogeneity. Previous studies have shown a relationship between the degree and location of hypertrophy and the prognosis of patients. The aim of this study was to compare left ventricular (LV) circumferential and longitudinal regional m... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is apoE-epsilon4 associated with reduced memory in long-standing intractable temporal lobe epilepsy? | [
"To investigate the relationship between the apolipoprotein (ApoE) epsilon4 allele and memory performance (verbal and nonverbal) in patients with medically intractable temporal lobe epilepsy (TLE) who underwent temporal lobectomy. Presurgical and postsurgical memory performance was examined in 87 adult patients wit... | [
"There is clinical and experimental evidence involving the insula in the control of the autonomic system and cardiac function, with differential participation of right and left brain hemispheres, and these differences could influence mortality in the acute phase of brain hemisphere ischemic infarcts. We have analyz... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does intestinal intraluminal injection of glutamine increase trolox total equivalent antioxidant capacity ( TEAC ) in hepatic ischemia-reperfusion? | [
"To evaluate the effects of intraluminal injection of glutamine on the serum trolox equivalent antioxidant capacity in an experimental model of ischemia-reperfusion of the liver observing the applicability of modifications on the original assay method. Thirty Wistar rats underwent laparotomy to perform a 20 cm blin... | [
"Xanthine oxidase has been implicated in the pathogenesis of a wide spectrum of diseases, and is thought to be the most important source of oxygen-free radicals and cell damage during re-oxygenation of hypoxic tissues. The present study was undertaken to demonstrate whether febuxostat is superior to allopurinol in ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does c-reactive protein cause downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice? | [
"Chronic elevations in circulating C-reactive protein (CRP) are associated with a greater risk of hypertension. Whether elevations in CRP cause hypertension is unknown. Chronic, conscious blood pressure (BP) measurements were performed by radiotelemetry in wild-type CF1 control and CF1 transgenic mice expressing ra... | [
"Estrogen deficiency increases the cardiovascular risks in postmenopausal women. Inhibition of the renin-angiotensin system (RAS) and associated oxidative stress confers a cardiovascular protection, but the role of RAS in estrogen deficiency-related vascular dysfunction is unclear. The present study investigates wh... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does preceptorship rurality affect medical students ' shelf exam scores? | [
"This study's objective was to determine whether junior medical students' end-of-rotation shelf exam scores varied by the preceptorship county's rurality. Student learning during rural preceptorship experiences, 1999 to 2005, was assessed using the students' scores on the National Board of Medical Examiners family ... | [
"The purpose of this study was to determine whether four types of professionalism deficiencies in medical students identified during a first-year course on doctor-patient relationships might predict poor performance in third-year clerkships. Preceptors identified students who had deficiencies in interviewing patien... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does ciclosporin reduce paracellin-1 expression and magnesium transport in thick ascending limb cells? | [
"Renal magnesium (Mg2+) wasting is one of the ciclosporin (CsA) tubular effects. The major site of Mg2+ transport is the thick ascending limb (TAL), where 70% of the ultrafiltrable Mg2+ is reabsorbed paracellularly. Paracellin-1 is a tight junction protein, which regulates the paracellular Mg2+ transport in the TAL... | [
"Thiazolidinediones (TZDs), such as rosiglitazone or pioglitazone, are peroxisome proliferator-activated receptor gamma (PPARγ) agonists currently used in the treatment of type 2 diabetes. However, their clinical applicability is limited by common and severe side effects including strong water retention, edema and ... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does statin pre-treatment protect brain against focal cerebral ischemia in diabetic mice? | [
"Cerebrovascular diseases and other vascular complications are common and cause considerable mortality and morbidity in diabetes mellitus. Recent studies suggest that statins reduce the incidence of stroke in diabetic as well as non-diabetic patients. The outcome of stroke is shown to be worse in diabetics. However... | [
"An elevated level of plasma homocysteine has long been suspected as a metabolic risk factor for the development of atherosclerotic vascular diseases in diabetes. Berberine (BBR) has several preventive effects on cardiovascular diseases. The effects of BBR on atherosclerotic plaque stability increased by homocystei... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does inhibition of heme oxygenase-1 protect against tissue injury in carbon tetrachloride exposed livers? | [
"During the metabolism of the hepatotoxin carbon tetrachloride (CCl(4)) by cytochrome P450, heme, and free radicals are released. Heme oxygenase (HO-1) is an enzyme that is induced by heme as well as oxidative stress and has been reported to be involved in mediating protection against toxic liver injury. The purpos... | [
"The endocannabinoid and eicosanoid lipid signaling pathways have important roles in inflammatory syndromes. Monoacylglycerol lipase (MAGL) links these pathways, hydrolyzing the endocannabinoid 2-arachidonoylglycerol to generate the arachidonic acid precursor pool for prostaglandin production. We investigated wheth... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is vEGF important for early liver regeneration after partial hepatectomy? | [
"The aim of the study was to determine the role of Vascular Endothelial Growth Factor (VEGF) on the microvasculature and on angiogenetic gene expression after partial hepatectomy (PH) in the rat model. To determine the effect of exogenous and endogenous VEGF after PH, rats were subjected to 70% PH and treated eithe... | [
"Cholestasis of the liver is known to be an important risk factor for surgical morbidity and mortality after major hepatectomy. However, the mechanism of liver injury in cholestatic liver is not fully understood. The goal of this study was to investigate the process of liver injury due to hepatic ischemia/reperfusi... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does low-dose phosphodiesterase inhibition improve responsiveness to inhaled nitric oxide in isolated lungs from endotoxemic rats? | [
"Inhalation of nitric oxide (NO) and inhibition of phosphodiesterase type 5 (PDE5) selectively dilate the pulmonary circulation in patients with acute lung injury (ALI) associated with pulmonary hypertension. PDE5 inhibitors administered at doses that decrease pulmonary artery pressures have been shown to worsen ar... | [
"Prolonged hypercapnia is commonly encountered during the treatment of acute respiratory distress syndrome and acute respiratory failure attributable to other causes with protective ventilation strategies. In these circumstances, compensatory renal buffering returns pH to normal establishing a condition of buffered... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is pre-hypertension a common phenomenon : national database study? | [
"Recently the Joint National Committee (7th report) introduced the term \"pre-hypertension.\" Little is known on its prevalence in the general population. To assess the prevalence of pre-hypertension in a large national cohort. We analyzed the database of all > or = 18 year old members of Leumit Health Services, on... | [
"What are the lifestyle choices and dietary aspects of women about to undergo fertility treatment in New Zealand?"
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does ebselen prevent chronic alcohol-induced rat hippocampal stress and functional impairment? | [
"Most of the previously published data suggest a role for oxidative or nitrosative stress in ethanol-induced nervous system damage. Moreover, ethanol is able to impair learning abilities in adult mammalian brain, a process suggested to be directly related to hippocampal neurogenesis. Ebselen, a synthetic compound w... | [
"Whole-brain irradiation (WBI) therapy produces learning and memory deficits in patients with brain tumours. Although the pathological cascade of cognitive deficits remains unknown, it may involve reduced neurogenesis within the hippocampus. Baicalein is a flavonoid derived from the roots of Huangqin, Scutellaria b... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Do [ Analysis of correlation factors affecting the incidence of burn shock ]? | [
"To analyze the correlation factors affecting the incidence of burn shock, so as to provide guidance for the clinical treatment of shock after burns. Retrospective analysis of clinical data of 15 624 patients hospitalized in our department from 1973 to 2005 was undertaken . The incidence of shock during every 10 ye... | [
"In order to definitude the influence caused by the different sampling in voice assessment. We comparing the results acquired by total section and subsection sampling. The results acquired by subsection tended to normal more than those acquired by total section."
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Do [ Evaluation of effectiveness and safety of a new hydroxyethyl starch used in resuscitation of burn shock ]? | [
"To evaluate the effectiveness and safety of hydroxyethyl starch (HES 130/ 0.4, 60 g/L) in resuscitation during shock stage of burns. Sixty-six burn patients who were admitted to hospital within 2 hours after burn injury requiring fluid resuscitation were enrolled into this study, and they were randomized into HES(... | [
"This study represents a subset of a complete data set, considering only those children aged admitted to the Pediatric Surgery and Pediatric Nephrology Clinics during the period January 2011 to July 2012. In this study, we have determined that the QT interval changes significantly depending on the use of oxybutynin... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does myocardial pre-synaptic sympathetic function correlate with glucose uptake in the failing human heart? | [
"We have previously shown that the myocardium of patients with heart failure (HF) is insulin resistant. Chronic beta-adrenergic stimulation has been implicated in insulin resistance in cultured cardiomyocytes in vitro, where sustained noradrenaline stimulation inhibited insulin-modulated glucose uptake. As the fail... | [
"Clinical and experimental studies demonstrate that exercise training improves aerobic capacity and cardiac function in heart failure, even in patients on optimal treatment with angiotensin inhibitors and beta-blockers, but the cellular mechanisms are incompletely understood. Since myocardial dysfunction is frequen... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does postural instability necessarily correlate to poor performance : case in point? | [
"It is very important for surgeons who perform minimally invasive surgery (MIS) to maintain proper postural stability, which kinematic research can determine. Previous studies in surgical ergonomics have shown that postural stability is correlated to instrument type, task difficulty, and skill level. What should al... | [
"ACL-deficient patients have been found to have proprioceptive defects, but the cause of these defects has not been identified nor has the relationship between proprioception and subjective function, laxity, activity level and age been adequately studied. Therefore, we analyzed proprioception, defined as the thresh... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does the use of porous beta-tricalcium phosphate block with platelet-rich plasma as an onlay bone graft biomaterial? | [
"An experimental study of rabbit calvaria evaluated the suitability of porous beta-tricalcium phosphate (beta-TCP) block as a biomaterial for onlay bone grafting and determined whether the addition of platelet-rich plasma (PRP) can accelerate bone formation inside the pores of the beta-TCP block. In eight rabbits, ... | [
"A rodent posterolateral spinal fusion model. This study evaluated a protamine-based polyelectrolyte complex (PEC) developed to use heparin in enhancing the biological activity of low-dose recombinant human bone morphogenetic protein-2 (rhBMP-2) in spinal fusion. rhBMP-2 is commonly regarded as the most potent bone... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Is extracellular signal-regulated kinase 1/2 involved in ascorbic acid-induced osteoblastic differentiation in periodontal ligament cells? | [
"Periodontal ligament (PDL) cells possess osteoblast-like properties and play key roles in periodontal regeneration. Previously, we have reported that ascorbic acid promotes the osteoblastic differentiation of PDL cells by modulating the type I collagen-integrin interaction. However, the signaling pathway activated... | [
"Although increasing evidence indicates that serotonin (SER; 5-hydroxytrypamine [5-HT]) is involved in the regulation of bone metabolism, conflicting data exist regarding whether SER promotes or inhibits osteoblast differentiation and bone formation. Regeneration of functional bone is required for proper osseointeg... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does vitamin K deficiency from long-term warfarin anticoagulation alter skeletal status in male rhesus monkeys? | [
"Vitamin K (K) inadequacy may cause bone loss. Thus, K deficiency induced by anticoagulants (e.g., warfarin) may be an osteoporosis risk factor. The skeletal impact of long-term warfarin anticoagulation was evaluated in male monkeys. No effect on BMD or bone markers of skeletal turnover was observed. This study sug... | [
"Slightly more than 5 % of the United States population heavily consumes ethanol, i.e., more than 14 drinks for men and 7 drinks for women a week. Chronic ethanol consumption can result in increased liver disease, reduced recovery from burn injury, and more frequent and severe respiratory infections. Chronic ethano... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Is respiratory syncytial virus infection in Fischer 344 rats attenuated by short interfering RNA against the RSV-NS1 gene? | [
"Respiratory syncytial virus (RSV) causes severe bronchiolitis and is a risk factor for asthma. Since there is no commercially available vaccine against RSV, a short interfering RNA against the RSV-NS1gene (siNS1) was developed and its potential for decreasing RSV infection and infection-associated inflammation in ... | [
"Chicken Mx belongs to the Mx family of interferon-induced dynamin-like GTPases, which in some species possess potent antiviral properties. Conflicting data exist for the antiviral capability of chicken Mx. Reports of anti-influenza activity of alleles encoding an Asn631 polymorphism have not been supported by subs... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does pretreatment with adenosine and adenosine A1 receptor agonist protect against intestinal ischemia-reperfusion injury in rat? | [
"To examine the effects of adenosine and A1 receptor activation on reperfusion-induced small intestinal injury. Rats were randomized into groups with sham operation, ischemia and reperfusion, and systemic treatments with either adenosine or 2-chloro-N(6)-cyclopentyladenosine, A1 receptor agonist or 8-cyclopentyl-1,... | [
"Salusins are multifunctional endogenous bioactive peptides simultaneously biosynthesized from their precursor prosalusin. Salusin-β stimulates proliferation of vascular smooth muscle cells and fibroblasts and regulates myocardial growth and hypertrophy. Salusin-β has potent hypotensive, bradycardic and proatherosc... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Does loss of Parp-1 affect gene expression profile in a genome-wide manner in ES cells and liver cells? | [
"Many lines of evidence suggest that poly(ADP-ribose) polymerase-1 (Parp-1) is involved in transcriptional regulation of various genes as a coactivator or a corepressor by modulating chromatin structure. However, the impact of Parp-1-deficiency on the regulation of genome-wide gene expression has not been fully stu... | [
"CHK2 kinase is a tumor suppressor that plays important role in DNA damage signaling, cell cycle regulation and DNA damage induced apoptosis. CHK2 kinase expression was known to be ubiquitous in mammalian cells. CHK2-/- cells were remarkably resistant to DNA damage induced apoptosis, mimicking the clinical behavior... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does elimination of laboratory ozone lead to a dramatic improvement in the reproducibility of microarray gene expression measurements? | [
"Environmental ozone can rapidly degrade cyanine 5 (Cy5), a fluorescent dye commonly used in microarray gene expression studies. Cyanine 3 (Cy3) is much less affected by atmospheric ozone. Degradation of the Cy5 signal relative to the Cy3 signal in 2-color microarrays will adversely reduce the Cy5/Cy3 ratio resulti... | [
"The availability of effective antiviral therapy for hepatitis C has increased the need for molecular detection and quantification of circulating hepatitis C viral particles. The limits of detection differ for the quantitative and qualitative reverse transcriptase polymerase chain reaction (RT-PCR) assays; furtherm... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
Are association between vision loss and higher medical care costs in Medicare beneficiaries costs greater for those with progressive vision loss? | [
"To identify the cost to the Medicare program for patients with either stable or progressive vision loss and to estimate the impact on eye-related and non-eye related care. Retrospective cohort study. The study population was Medicare beneficiaries included in the standard 5% analytic sample and continuously enroll... | [
"To quantify the increase in the likelihood of a fall injury and medical costs of treating fall injuries among elderly individuals with select mental health (MH), substance abuse (SA), and cognitive disorders compared with the general elderly population. The authors used a random sample (N = 601,922) of claimants i... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Is cataract surgery associated with a higher rate of photodynamic therapy for age-related macular degeneration? | [
"To investigate the association between cataract surgery and the rate of photodynamic therapy (PDT) for age-related macular degeneration (AMD). Observational population-based retrospective case-control study. All members in a district of the largest health maintenance organization (HMO) in Israel > 50 years old on ... | [
"The purpose of this study is to report a case of diabetic macular edema that resolved after systemic bevacizumab. This is an observational case report of a patient with diabetic macular edema. After initiation of systemic bevacizumab for a central nervous system glioblastoma, the diabetic macular edema resolved."
... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Does spontaneous bacterial peritonitis result in oxidative and nitrosative stress in ascitic fluid? | [
"Spontaneous bacterial peritonitis (SBP) is a major complication of liver cirrhosis and accounts for significant mortality. Although oxygen free radicals and nitric oxide been implicated in the pathophysiology of liver cirrhosis, information on their role during the development of SBP is scarce. This study examined... | [
"Uremia-associated immune deficiency is a well-known complication of loss of renal function and contributes significantly to the overall mortality and morbidity of patients with end-stage renal disease. Chronic inflammation and increased oxidative stress are underlying the uremia-associated immune deficiency."
] | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant passages:",
"pos": "Represent the Biomedical passage for retrieval:",
"neg": "Represent the Biomedical passage for retrieval:"
} |
Are maternal hepatitis B virus ( HBV ) DNA positivity and sexual intercourse associated with HBV intrauterine transmission in China : a prospective case-control study? | [
"Hepatitis B virus (HBV) intrauterine transmission from infected mothers contributes significantly to the persistence of the high number of HBV carriers. The aim of this study was to identify potential risk factors for HBV intrauterine transmission. A case-control study was performed on pregnant women tested positi... | [
"Many clinicians do not encourage breastfeeding in hepatitis B virus (HBV) carriers, since HBV DNA can be detected in breast milk and breast lesions may increase exposure of infants to HBV. The aim of this study was to determine whether breastfeeding may add risk for perinatal HBV transmission. Totally 546 children... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Does mild zinc deficiency and dietary phytic acid accelerate the development of fulminant hepatitis in LEC rats? | [
"Restriction of copper intake delays hepatic copper accumulation in Long-Evans Cinnamon (LEC) rats, which are animal models of Wilson's disease. Involvement of zinc is suggested to develop hepatitis in the disease; however, this has not been clarified. The aims of this study were to investigate the effects of mild ... | [
"Large-scale epidemiological studies have shown that drinking more than two cups of coffee per day reduces the risks of hepatitis and liver cancer. However, the heterogeneity of the human genome requires studies of experimental animal models with defined genetic backgrounds to evaluate the coffee effects on liver d... | pubmedqa | {
"query": "Represent the Biomedical query for retrieving relevant paragraphs:",
"pos": "Represent the Biomedical paragraph for retrieval:",
"neg": "Represent the Biomedical paragraph for retrieval:"
} |
Do different components of opioid-substitution treatment predict outcomes of patients with and without a parent with substance-use problems? | [
"The aim of this study was to determine how the treatment needs and outcomes of polysubstance-using patients entering opioid-substitution treatment (OST) may be affected if the patient had a parent with substance-use problems. This prospective observational study examined outcomes of 255 patients (97% male) enterin... | [
"The goal of methadone maintenance treatment (MMT) is to reduce the harm and to improve patients' quality of life (Qol). However, the Qol is also influenced by other co-occurring disorders. Data regarding the Qol and the co-occurrence of these disorders is lacking in low-middle income countries. We therefore descri... | pubmedqa | {
"query": "Represent the Biomedical question for retrieving relevant documents:",
"pos": "Represent the Biomedical document for retrieval:",
"neg": "Represent the Biomedical document for retrieval:"
} |
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