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train · 100 rows

questions_and_answers listlengths 1 24	all_concepts stringlengths 15 908	multiconcept_reasoning_questions stringlengths 4.89k 310k
[ { "answer": "in the canals of hering", "extracted_concepts": [ "oval cells", "liver stem cells", "canals of hering" ], "question": "where are liver stem cells (oval cells) located?" }, { "answer": "bile duct cells and canals of hering", "extracted_concepts": [ "immunohistochemical stain for cytokeratin 7", "bile duct cells", "canals of hering" ], "question": "what are stained here with an immunohistochemical stain for cytokeratin 7?" }, { "answer": "an immunohistochemical stain", "extracted_concepts": [ "bile duct cells", "cytokeratin 7", "immunohistochemical stain", "canals of hering" ], "question": "what are bile duct cells and canals of hering stained here with for cytokeratin 7?" }, { "answer": "yes", "extracted_concepts": [ "bile duct cells", "cytokeratin 7", "immunohistochemical stain", "canals of hering" ], "question": "are bile duct cells and canals of hering stained here with an immunohistochemical stain for cytokeratin 7?" } ]	["immunohistochemical stain for cytokeratin 7", "cytokeratin 7", "bile duct cells", "immunohistochemical stain", "liver stem cells", "oval cells", "canals of hering"]	{"immunohistochemical stain for cytokeratin 7": {"yes_questions": {"contexual_properties": ["Does the image show areas with increased staining intensity in regions that could correspond to carcinomas or reactive epithelial cells?", "Are there regions in the image where staining is absent in structures that might represent hepatocytes, colorectal carcinoma, or squamous epithelium?", "Can you identify patchy staining patterns that could indicate heterogeneous tumors, such as ovarian or endometrial cancers?", "Is there reduced staining intensity in areas that may correspond to poorly differentiated tumors or regions with low protein expression?", "Does the image display diffuse staining in regions that could represent uniformly expressing tissues, such as lung or breast adenocarcinoma?", "Are there focal staining patterns that might be associated with tumors like urothelial carcinoma?", "Can you observe cytoplasmic localization of the stain in epithelial cells, consistent with intermediate filament proteins?", "Is there evidence of membranous staining that could be attributed to fixation artifacts or specific tumor subtypes?", "Do any tumor regions show more prominent staining, suggesting a CK7-positive origin such as cholangiocarcinoma or serous carcinoma?", "Are there areas where staining is lost, possibly indicating dedifferentiation or epithelial-mesenchymal transition?", "Can you detect aberrant staining patterns that might be due to neoplastic transformation, genetic mutations, or technical artifacts?", "Is there increased staining intensity in inflamed tissue, suggesting upregulation in reactive epithelial cells?", "Does the image reveal heterogeneous staining in tumors with mixed cell populations or variable protein expression?", "Are there granular staining patterns that could be due to cytoplasmic aggregation or specific fixation conditions?", "Is there increased background staining that might result from inadequate blocking, high antibody concentration, or poor tissue processing?", "Do necrotic areas show weaker staining, possibly due to protein degradation and loss of antigenicity?", "Is there any nuclear staining present, which could indicate a technical artifact rather than true protein localization?", "Are there regions of more intense staining in regenerative tissue where epithelial proliferation may be occurring?", "Can you observe altered distribution of staining in areas that might correspond to dysplastic or neoplastic tissue?", "Is staining more prominent at the invasive front of a tumor, suggesting active invasion by epithelial cells?"], "properties": ["Does the image show cells with a brown coloration indicating a positive reaction to a specific chromogen?", "Can you identify a staining pattern that is cytoplasmic, possibly with membranous accentuation, in epithelial cells?", "Is there evidence of a highly sensitive method for detecting epithelial cells expressing a particular intermediate filament protein?", "Does the image display a staining result that is highly specific for a protein with a molecular weight of approximately 54 kilodaltons?", "Can you observe a chromogenic reaction that is likely due to the use of 3,3'-diaminobenzidine (DAB)?", "Is there visual evidence suggesting the use of an antibody of the IgG isotype in the staining protocol?", "Does the staining pattern suggest that the optimal antibody dilution was within the range of 1:50 to 1:200?", "Can you infer that the incubation time for the staining procedure was between 30 and 60 minutes at room temperature based on the staining intensity and pattern?", "Is there any indication that the buffer pH used during the staining process was between 6.0 and 7.0?", "Does the image suggest that heat-induced epitope retrieval with citrate buffer was performed prior to staining?", "Can you deduce that the staining reagent was likely stored at 2\u20138\u00b0C to maintain its effectiveness?", "Is there evidence that the reagent used in the staining process has a shelf life of 12 to 24 months when properly stored?", "Does the staining intensity suggest a detection limit in the low nanogram per milliliter range for the target protein?"], "relational": ["Does the image show a staining pattern that could be used to analyze tissues such as the lung, breast, or ovary?", "Is there evidence of a stain highlighting simple, glandular, or transitional epithelial cells?", "Can you identify regions where ductal, glandular, or transitional epithelium is marked by a specific stain?", "Does the image contain structures from organs commonly associated with cytoskeletal protein expression, such as the pancreas or biliary tract?", "Is there a staining pattern that helps detect or characterize epithelial tissues based on their cytoskeletal proteins?", "Can you see areas where the staining could be compared to other cytokeratin stains, such as cytokeratin 20 or cytokeratin 8?", "Does the image include cells from the respiratory, female genital, urinary, or gastrointestinal tracts that are highlighted by a particular stain?", "Are there epithelial layers, glandular structures, or ductal regions that are distinctly marked in the image?", "Can you assess cellular localization, staining intensity, or distribution pattern in the stained tissue?", "Is there evidence of a cytoskeletal protein from the intermediate filament family being visualized in epithelial cells?"], "contexual_behavior": ["Does the image show increased staining intensity in tumor regions that could originate from epithelial cells of the lung or breast?", "Is there evidence of reduced detection of epithelial cells in areas with chronic inflammation or apparent epithelial loss?", "Can you identify regions of a carcinoma with diminished staining, suggesting a loss of epithelial differentiation?", "Does the staining pattern appear altered in areas that might represent metastatic cancer, possibly indicating phenotypic adaptation?", "Is there evidence that combining this stain with other markers, such as CK20 or TTF-1, could help distinguish between primary and metastatic tumors in the image?", "Are there regions of necrotic tissue where the staining appears less sensitive or diminished, possibly due to antigen loss?", "Do areas showing squamous cell differentiation exhibit decreased positivity with this stain?", "Is there enhanced detection of ductal epithelial cells in regions that appear to be undergoing tissue regeneration?", "Does the staining fail to clearly differentiate between benign and malignant lesions in areas that might be affected by hypoxia?", "Are there regions with increased background staining, possibly due to inflammation or nonspecific binding?", "Can you observe any alteration in staining patterns that might be attributed to differences in tissue fixation methods?", "Is there reduced detection of epithelial cells in areas with extensive fibrosis, suggesting limited antibody penetration?", "Does the staining pattern support a diagnosis of cholangiocarcinoma over hepatocellular carcinoma by showing strong positivity in cholangiocyte-rich regions?", "Are there areas where staining is impaired, possibly due to autolytic changes and antigen degradation?", "Do you see enhanced staining in tissues that might have been exposed to chemotherapeutic agents, indicating upregulation of the target antigen?"], "functions": ["Does the image show evidence of a technique used to detect a specific protein within tissue samples?", "Can you identify areas where certain cells are highlighted due to the expression of a particular cytoskeletal protein?", "Is there a staining pattern that could help differentiate between various epithelial tissues?", "Does the image provide visual cues that could assist in identifying the origin of a tumor based on protein expression?", "Can you see features that might be used to distinguish between different tumor subtypes according to their biomarker status?", "Is there evidence of a method that supports the identification of metastatic tumors by revealing positive staining in secondary sites?", "Does the image contain information that could be used to monitor changes in protein expression during tumor development?", "Can you observe staining that would be relevant for guiding treatment decisions based on diagnostic findings?", "Is there a pattern present that could assist in evaluating the lineage or differentiation status of epithelial cells?", "Does the image provide visual information that could be used for functional characterization of tumors through assessment of a specific protein marker?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image contain a structure with a density close to 1.05 grams per cubic centimeter?", "Does the image show an object with a smooth surface and fine transverse striations?", "Does the image show an object that might have a protein content of 10 to 20 percent of its dry weight?"], "relational": ["Does the image show an organism encountering barriers such as gastric acid, intestinal mucus, or the anal sphincter?", "Is there a structure associated with the large intestine or anus in the image?", "Can you see signs of egg deposition or irritation in the perianal area?"], "contexual_behavior": ["Is there an organism present that cannot complete its life cycle in non-human hosts due to host specificity?", "Is there an organism that increases its nocturnal activity to deposit eggs on the perianal skin, emerging at night in sync with the host's circadian rhythm?", "Does the image show an organism that increases its reproductive activity when its human host is asleep at night?"], "functions": ["Is there visual evidence of rapid reproduction or multiple life stages of a parasite within the intestinal lumen?", "Is there evidence of an organism colonizing the colon or rectum in the image?", "Is there a structure that could be responsible for gastrointestinal symptoms such as abdominal discomfort?"]}}, "cytokeratin 7": {"yes_questions": {"contexual_properties": ["Is there a region in the image where epithelial cell proliferation or tissue regeneration is suggested by increased staining intensity?", "Can you identify areas where staining is more pronounced in association with carcinoma, such as lung or breast cancer?", "Does the image show weaker staining in regions undergoing squamous differentiation or in poorly differentiated tumors?", "Are there areas with overexpression of a marker typically seen in adenocarcinomas, cholangiocarcinomas, or ovarian cancers?", "Can you observe more intense staining in hyperplastic epithelial lesions or in malignant tumors?", "Is there evidence of weaker staining in regions showing loss of epithelial features or advanced tumor dedifferentiation?", "Do you see changes in the distribution of a cytoskeletal protein in cells undergoing epithelial-mesenchymal transition or experiencing cellular stress?", "Is there abnormal localization of a cytoskeletal component in areas of neoplastic transformation or cytoskeletal disruption?", "Can you detect fragmented staining patterns in regions where apoptosis or proteolytic cleavage by caspases might be occurring?", "Are there areas where the molecular weight of a stained protein appears altered, possibly due to post-translational modifications or mutations?", "Is there a complete absence of staining in tissues lacking simple epithelial cells or in regions where expression is lost in certain cancers?", "Do you see cytoplasmic accumulation of a protein in areas with impaired protein degradation or cellular stress?", "Are there regions showing unexpected staining in tissues where this marker is normally absent, as might occur in metaplasia or metastatic tumors?", "Can you identify changes in isoform composition of a stained protein, potentially due to alternative splicing or disease-associated mutations?", "Is there evidence of increased glycosylation of a cytoskeletal protein in cancerous or stressed cells?", "Do you observe abnormal aggregation of a protein in regions affected by protein misfolding disorders or oxidative stress?"], "properties": ["Does the image show a brown staining pattern in epithelial cells that could indicate the presence of a protein encoded by a gene located on chromosome 12q13.13?", "Is there evidence of a cytoplasmic or perinuclear localization of a protein typically expressed at moderate to high levels in simple or glandular epithelial cells?", "Can you identify a structure that might contain a type II keratin with an alpha-helical coiled-coil domain?", "Does the image display staining consistent with a protein that is generally insoluble in physiological buffers but can be solubilized with detergents?", "Is there a visible marker that could correspond to a protein with a molecular weight of approximately 51 kilodaltons?", "Can you see staining that may represent a protein with a length of 469 amino acids?", "Does the image suggest the presence of a protein that is subject to post-translational modifications such as phosphorylation or glycosylation?", "Is there a feature in the image that could be explained by the presence of a protein with a normal half-life of several days in cells?", "Does the staining pattern suggest a protein with an isoelectric point around 5.2?", "Can you identify a structure that would be present in the cytoplasm, particularly around the nucleus, of epithelial cells?", "Is there evidence of a protein that is typically found in low micromolar concentrations in human epithelial tissues?", "Does the image show a pattern consistent with a protein whose secondary structure is predominantly alpha helix with some random coil regions?"], "relational": ["Does the image show epithelial cells that could be identified by the presence of intermediate filaments within their cytoplasm?", "Can you find glandular or ductal epithelial structures that might be positive for a cytoskeletal marker commonly found in the lung, breast, or ovary?", "Is there evidence of transitional or glandular epithelium in regions such as the respiratory tract or female genital tract?", "Does the image contain anatomical features like bile ducts or urothelium that are typically identified using specific epithelial markers?", "Are there epithelial cells present that might co-express cytoskeletal proteins used in diagnostic panels for distinguishing glandular tumors?", "Can you identify areas of tissue that are likely to express intermediate filament proteins from the cytokeratin family?", "Is there a visible epithelial layer in the urinary tract or endometrium that could be positive for a marker not found in stratified squamous or gastrointestinal epithelium?", "Does the image show any glandular tumors or ductal structures that could be highlighted by a cytoskeletal network marker?", "Are there regions where epithelial cells are present but are unlikely to express this marker, such as stratified squamous epithelium or hepatocytes?"], "contexual_behavior": [], "functions": ["Does the image show epithelial cells with evidence of a structural protein providing mechanical support?", "Can you identify a filamentous network within the cytoplasm that reinforces the cytoskeleton of epithelial cells?", "Is there a visible feature suggesting the maintenance of cell shape and stability through a resilient filament network?", "Does the image contain cells that could be distinguished by a marker indicative of specific epithelial lineages or differentiation states?", "Can you see evidence of tissue repair, such as cell migration or re-epithelialization, in epithelial tissue?", "Is there a structure that might be involved in modulating cell signaling pathways within epithelial cells?", "Does the image show features consistent with protection from mechanical stress, such as force distribution across the cytoskeleton?", "Can you observe intermediate filaments anchoring organelles and maintaining cellular architecture in epithelial cells?", "Is there evidence of regulation of cell proliferation or maintenance of epithelial homeostasis in the image?", "Does the image display signs of cytoskeletal reorganization or tissue regeneration in response to cellular injury?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you observe skin that appears swollen, stretched, and shiny due to extensive fluid retention?", "Does the image show swelling with a normal capillary refill time, typically less than 2 seconds?", "Is there evidence of significant weight gain, possibly in the range of 5 to 20 kilograms or more?"], "relational": ["Does the image show alterations in organs such as the liver, kidneys, heart, or lungs that might be related to fluid overload?", "Is there visible involvement of tissues like connective or interstitial tissue with signs of fluid retention?", "Can you see features suggesting impaired lymphatic drainage or lymphatic dysfunction?"], "contexual_behavior": [], "functions": ["Is there evidence of increased distance between capillaries and cells that could impair nutrient or oxygen delivery?", "Can you identify visual cues that might suggest cardiovascular strain, such as signs consistent with increased preload or heart failure?", "Does the image reveal tissue changes that could result in impaired perfusion or cellular dysfunction?"]}}, "bile duct cells": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show cells that are between 10 and 20 micrometers in diameter?", "Can you identify cells with a cuboidal or columnar shape?", "Is there evidence of mononuclear cells present in the image?", "Do any cells display cytoplasm containing organelles such as mitochondria, endoplasmic reticulum, or Golgi apparatus?", "Are there cells that appear pale eosinophilic or light pink under the microscope?", "Can you see cells with moderate mitochondrial content, suggesting active transport or secretion?", "Are there cells that might express proteins like cytokeratin 7, cytokeratin 19, or epithelial cell adhesion molecule?", "Do any cells appear to have low lipid content under normal physiological conditions?", "Is there evidence of cells with minimal glycogen compared to neighboring hepatocytes?", "Can you identify cells whose cytoplasmic pH is likely to be around 7.0 to 7.4?", "Are there cells where water appears to constitute a significant portion of their mass, approximately 70\u201380%?", "Do you see cells with a density close to 1.05 grams per cubic centimeter?", "Are there cells that might express surface markers such as CK19, EpCAM, or MUC1?", "Can you identify cells with an estimated lifespan of several months?"], "relational": ["Does the image show cellular components of the digestive or hepatic system?", "Can you identify cells located within the liver?", "Is there evidence of structures such as bile ducts or intrahepatic ducts?", "Does the image display ducts lined by specialized cells?", "Are there cells surrounded by connective tissue or hepatic parenchyma?", "Can you see anatomical connections to features like the Canals of Hering or portal triads?", "Are there cells adjacent to hepatocytes or Kupffer cells?", "Does the image show cells participating in bile transport or secretion?", "Can you identify regions such as portal tracts or the biliary tree containing specialized cells?", "Is there a cellular component present within the biliary system or hepatic lobule?"], "contexual_behavior": [], "functions": ["Does the image show a structure that lines a conduit for bile flow from the liver to the gallbladder or intestine?", "Can you identify cells or regions involved in modifying or secreting bile?", "Is there evidence of a barrier protecting the biliary tract from toxins?", "Does the image display features consistent with secretion or absorption processes that regulate bile volume or composition?", "Can you see any indication of bicarbonate secretion or electrolyte regulation within the bile ducts?", "Is there a visible epithelial lining that could provide structural support or form tight junctions?", "Does the image suggest the presence of cells contributing to extracellular matrix production in the bile duct region?", "Can you identify structures that might be involved in immune surveillance or cytokine secretion in response to pathogens?", "Is there evidence of cellular proliferation or repair activity in response to injury or inflammation within the biliary tract?", "Does the image show features that could be associated with water transport or pH regulation in bile?", "Can you see any indication of paracrine signaling or immune modulation between cells in the liver region?", "Is there a visible interaction between the duct lining and neighboring hepatocytes or Kupffer cells?"]}, "no_questions": {"contexual_properties": ["Do any masses display a change in contrast relative to surrounding tissue, potentially reflecting changes in density or composition?", "Does the image show an increased number of masses, possibly indicating multifocal tumor development or new lesion formation?", "Are there any masses that have decreased in size, which might indicate a response to therapy or regression?"], "properties": ["Does the image contain an area that is slightly more hyperdense or light gray than the surrounding parenchyma?", "Can you find an area with a heterogeneous or inhomogeneous internal texture?", "Are calcifications rarely or infrequently observed within any of the subtle masses present?"], "relational": ["Can you identify a mass-like feature that appears within the breast parenchyma or mammary glands?", "Is there a subtle area that could be associated with microcalcifications?", "Is there a subtle abnormality present in the upper outer quadrant, central breast, or subareolar area?"], "contexual_behavior": ["Is there an area where a lesion appears more detectable, potentially due to transient changes in breast tissue during the luteal phase of the menstrual cycle?", "Can you see a mass with altered or irregular margins that could be associated with prior surgical intervention or architectural distortion?", "Is there a region in the image where dense tissue makes it difficult to distinguish the borders of a lesion?"], "functions": ["Is there evidence of structural heterogeneity or loss of organized tissue patterning?", "Are there subtle regions that appear denser or stiffer than the surrounding tissue?", "Is there visual evidence of increased cellular density or abnormal tissue organization?"]}}, "immunohistochemical stain": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of a staining procedure involving both antibodies and chromogenic substrates?", "Can you identify areas with a brown or red coloration that could result from the use of specific chromogens?", "Is there visual evidence of a reaction that might require a pH between 6.0 and 7.5 for optimal results?", "Does the staining intensity in the image appear weak, moderate, or strong, suggesting variable antigen expression?", "Can you observe a staining pattern that would indicate high specificity for a particular antigen?", "Is there evidence of a staining protocol that could achieve sensitivity greater than 90%?", "Does the image suggest the use of a liquid reagent at room temperature?", "Can you infer whether the staining procedure might have involved an incubation period ranging from 30 minutes to overnight?", "Is there any indication that the staining reagents used are soluble in aqueous buffers or organic solvents?", "Does the image suggest that the staining procedure required a small volume, such as 50 to 200 microliters per slide?", "Can you infer from the image whether the staining protocol might have used a dilution factor between 1:50 and 1:1000?", "Is there any visual clue that the staining reagents should be stored at temperatures between 2 and 8 degrees Celsius?", "Can you deduce from the staining pattern whether the antibodies used could have a molecular weight in the range of 150 to 160 kDa?", "Does the image suggest that the staining reagents might have a shelf life of 6 to 24 months depending on storage conditions?", "Is there evidence in the image that buffer solutions were used as part of the staining process?"], "relational": ["Does the image show a tissue sample that could be from a tumor or a normal organ?", "Can you identify a specimen that might be a biopsy section?", "Is there evidence of staining that highlights cellular structures such as membranes, nuclei, or cytoplasm?", "Does the image contain cells that could be epithelial cells, lymphocytes, or neurons?", "Can you see a tissue section from regions like lymph nodes, brain, breast, or prostate?", "Is there a sample that appears to be prepared for detecting specific antigens?", "Does the image show tissue from the nervous, immune, or endocrine system?", "Can you observe staining patterns that might indicate the presence of proteins or antigens?", "Is there visualization of cellular organelles such as nuclei or mitochondria?", "Can you see evidence of cell surface markers being highlighted?", "Does the image appear to be a histological slide prepared for visualizing specific molecules?", "Is there a specimen that could be formalin-fixed, paraffin-embedded tissue, a frozen section, or a cytology smear?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a technique used to visualize specific antigens within tissue sections?", "Can you identify a method in the image that highlights the presence of particular proteins by producing a visible signal?", "Is there a visible indication of antibody binding to target antigens in the tissue sample?", "Does the image reveal areas where disease markers are detected through the presence or absence of specific molecular targets?", "Can you observe abnormal protein expression patterns that might aid in pathological diagnosis?", "Is there evidence of unique cellular markers being labeled to distinguish between different cell types?", "Does the image display localized color changes that correspond to the distribution of specific antigens?", "Can you identify features that would assist in classifying tumor origin or subtype based on tumor-specific antigen detection?", "Is there visual information suggesting the detection of markers indicative of particular stages or lineages of cell development?", "Does the image show labeling of pathogen-specific antigens that could indicate the presence of infectious agents?", "Can you observe visualization of immune cell markers or cytokine expression patterns that would support evaluation of immune responses in the tissue?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is the cytoplasmic-to-nuclear ratio preserved and similar to that of normal endometrial cells?", "Can you identify a region where the tissue thickness appears moderately increased, approximately 1 to 2 millimeters?", "Do the nuclei display a fine, evenly distributed chromatin pattern without hyperchromasia?"], "relational": ["Does the image show a histological section where the epithelial layer, glandular layer, or subepithelial stroma appears thickened but orderly?", "Can you identify an area where epithelial or glandular cells are more numerous but maintain normal nuclear appearance?", "Is there evidence of increased glandular or epithelial layers adjacent to the basement membrane or connective tissue, but without abnormal nuclear features?"], "contexual_behavior": ["Does the image suggest increased persistence of endometrial proliferation that could be associated with an immunocompromised state?", "Does the image reveal changes in endometrial growth dynamics that might be linked to perimenopausal hormonal fluctuations?", "Is there a region where endometrial tissue appears expanded, possibly due to prolonged estrogen exposure without opposing progestin?"], "functions": ["Is there a region where the architecture of the tissue appears preserved despite an apparent increase in cell density?", "Does the image show a tissue with an increased number of cells while maintaining normal cellular appearance and organization?", "Can you observe a shift toward cell growth over cell death, while overall tissue homeostasis and normal appearance are preserved?"]}}, "liver stem cells": {"yes_questions": {"contexual_properties": ["Does the image show an increase in the number of cells in regions associated with tissue regeneration or liver injury?", "Can you observe a decrease in the population of certain cells following signs of tissue repair or cell death?", "Is there evidence of cells changing in size, possibly indicating activation or differentiation processes?", "Do any cells exhibit altered morphology that could suggest a transition toward hepatocytes or cholangiocytes?", "Are there cells with abnormal inclusions that might indicate steatosis or a storage disease?", "Can you detect changes in marker expression levels among cells, potentially reflecting activation, differentiation, or disease states?", "Is there a region where cells appear more proliferative in response to liver damage or growth factor stimulation?", "Do you see changes in cell composition that could be linked to differentiation or microenvironmental influences?", "Are there cells with altered surface protein patterns, possibly due to activation, disease, or lineage specification?", "Can you identify dysplastic features in cells within areas affected by chronic liver disease or pre-neoplastic transformation?", "Is there evidence of increased apoptosis among cells, such as those exposed to toxic injury or cellular stress?", "Do any cells display changes in their differentiation potential under altered signaling or disease conditions?", "Are there cells with visible chromosomal abnormalities, suggesting genetic instability or malignancy?", "Can you observe enlarged cells that may be undergoing activation, senescence, or pathological stress?", "Do any cells show cytoplasmic changes consistent with differentiation, metabolic stress, or disease?", "Is there evidence of altered metabolic activity in cells responding to activation, differentiation, or environmental changes?", "Are there cells with vacuoles that could indicate cellular injury or metabolic disturbance?", "Do you notice abnormal staining patterns in cells, possibly due to disease, altered protein expression, or cellular damage?", "Is there a loss of typical cell shape that might be associated with apoptosis, necrosis, or malignant transformation?", "Can you identify cells with altered nuclear size, potentially reflecting activation, dysplasia, or neoplastic progression?"], "properties": ["Does the image show cells that are approximately 10 to 15 micrometers in diameter?", "Can you identify round or oval-shaped cells with a small size?", "Are there cells present that display a high nuclear-to-cytoplasmic ratio and scant cytoplasm?", "Is there evidence of cells that appear colorless or slightly basophilic under standard staining?", "Can you see cells that might express surface markers such as EpCAM, CD133, or CD90?", "Are there cells likely to have high levels of stemness genes like SOX9, NANOG, or OCT4?", "Do any cells exhibit moderate mitochondrial content, suggesting an undifferentiated state?", "Is there a population of cells with a higher proliferation rate than mature hepatocytes, possibly doubling every 24 to 48 hours?", "Can you identify cells that might have elevated telomerase activity compared to differentiated liver cells?", "Are there cells with a viability percentage above 85% under optimal conditions?", "Do any cells express proteins such as alpha-fetoprotein or cytokeratin 19, indicating early hepatic lineage?", "Is there a group of cells with low to moderate lipid content compared to mature hepatocytes?", "Can you observe cells with low cytoplasmic granularity due to minimal organelle content?", "Are there cells that could have a lifespan of several weeks to a few months in vitro?", "Is there evidence of cells containing approximately 6 picograms of DNA per diploid cell?", "Do any cells exhibit a diploid chromosomal content, specifically 46 chromosomes?", "Are there cells that would thrive in an environment with a pH between 7.2 and 7.4?"], "relational": ["Does the image show a structure that is part of the hepatic system?", "Can you identify a region within the liver that contains specialized canals, such as the canals of Hering?", "Is there evidence of cells that could give rise to hepatocytes or cholangiocytes?", "Does the image display areas where hepatic progenitor cells might be present?", "Can you see tissue regions that interact with the hepatic parenchyma or portal tracts?", "Is there a visible anatomical feature corresponding to periportal regions within the liver?", "Does the image include structures associated with branches of the portal vein or hepatic artery?", "Can you identify a region in the upper right abdominal quadrant that contains cellular niches?", "Is there a structure that could be related to the gallbladder or pancreas in proximity to the liver?", "Does the image show features consistent with a periportal niche or the canals of Hering?"], "contexual_behavior": ["Does the image show evidence of increased regenerative activity in response to acute liver injury, suggesting activation of a cell population when hepatocyte proliferation is insufficient?", "Is there a visible reduction in differentiation into hepatocytes in the context of chronic liver disease, possibly due to persistent inflammation?", "Can you identify a failure of cellular proliferation in a fibrotic microenvironment, such as might be seen in cirrhosis?", "Does the image suggest enhanced tissue repair following partial removal of liver tissue, indicating activation of a regenerative cell population?", "Is there a decline in the ability to repopulate damaged liver tissue in an aging context, potentially due to cellular senescence?", "Can you observe impaired cellular function in the presence of hepatotoxic drugs, possibly due to direct toxicity or altered signaling?", "Does the image indicate increased cellular activation in response to acute inflammation, perhaps stimulated by inflammatory cytokines?", "Is there evidence of regenerative capacity loss in areas with significant extracellular matrix deposition, as seen in fibrosis?", "Can you detect behavioral changes in response to immune-mediated injury, such as might occur during viral hepatitis infection?", "Does the image suggest reduced self-renewal or proliferation under oxidative stress, possibly due to reactive oxygen species damage?", "Is there an increase in differentiation toward biliary cells following bile duct injury, indicating a shift in lineage commitment?", "Can you see a failure to restore normal liver function in the context of metabolic liver disease, possibly due to genetic defects or persistent metabolic stress?", "Does the image show enhanced proliferation during liver regeneration after transplantation, suggesting abundant regenerative cues?", "Is there a reduction in cellular activity that could be attributed to impaired microenvironmental signaling, such as a lack of essential growth factors or extracellular matrix components?", "Can you observe altered cellular function in the setting of non-alcoholic fatty liver disease, potentially due to lipid accumulation and inflammation?", "Does the image indicate an increased response to growth factors during tissue repair, possibly due to upregulation of receptor expression?", "Is there a failure of cellular activation in the context of end-stage liver disease, potentially due to extensive tissue damage or stem cell exhaustion?", "Can you detect a decline in regenerative output during chronic alcohol exposure, possibly as a result of ethanol toxicity?", "Does the image suggest increased migration of cells to sites of injury, potentially in response to chemokines or damage-associated signals?", "Is there evidence of impaired differentiation in the context of genetic liver disorders, possibly due to inherited mutations affecting lineage specification?"], "functions": ["Does the image show any cells that might be involved in self-renewal or differentiation to maintain liver tissue?", "Can you identify structures that could contribute to liver regeneration by forming new hepatocytes or cholangiocytes after injury?", "Is there evidence of cells participating in tissue repair by replacing lost or damaged liver cells?", "Does the image display cells that appear activated, proliferating, or migrating toward areas of liver damage?", "Can you see any cellular activity that suggests maintenance of liver homeostasis through replenishment of mature liver cells?", "Is there visual indication of cells differentiating into specialized liver cell types, possibly guided by microenvironmental cues?", "Does the image show evidence of hepatocyte replacement through proliferation and differentiation?", "Are there features suggesting the formation of major hepatic cell lineages during liver development?", "Can you observe any signs of cellular turnover, where a balance between self-renewal and differentiation is maintained?", "Is there visual evidence of tissue regeneration or anti-fibrotic effects that might occur during chronic liver disease repair?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of a well-vascularized layer containing numerous small blood vessels beneath another structure?", "Is there a region that would be expected to have a slightly alkaline pH, around 7.35 to 7.45?", "Does the image show a layer that could exhibit moderate elasticity due to elastin and collagen fibers?"], "relational": ["Is there evidence of connective tissue, such as lamina propria or submucosa, situated beneath a mucosal or epithelial layer?", "Can you identify a tissue interface in the skin, oral cavity, or gastrointestinal tract where support and nourishment are provided to an overlying layer?", "Does the image contain features such as extracellular matrix, blood vessels, or nerve fibers supporting a layer beneath an epithelium?"], "contexual_behavior": ["Can you identify areas that might be experiencing reduced blood flow or oxygen delivery, indicating possible ischemia or hypoxia?", "Can you identify delayed healing or poor matrix formation in areas where nutrient deficiency or malnutrition may be present?", "Are there features such as necrosis or ulceration that might result from prolonged pressure exposure and functional changes beneath the surface?"], "functions": ["Can you identify areas where capillary networks facilitate the exchange of gases or nutrients with surrounding tissues?", "Does the image reveal a structure that connects or anchors different tissue layers, contributing to overall stability?", "Is there evidence of tissue that might participate in wound healing, such as the presence of fibroblasts or extracellular matrix components?"]}}, "oval cells": {"yes_questions": {"contexual_properties": ["Does the image show an increased population of cells in the liver that might indicate impaired proliferation of the main parenchymal cells during injury or regeneration?", "Can you identify a decrease in a specific cell type as liver recovery progresses and normal parenchymal cells are restored?", "Is there evidence of cells changing in size in regions associated with liver damage or repair processes?", "Does the image reveal a prominence of certain cells in areas affected by chronic liver disease, cirrhosis, or exposure to hepatotoxic substances?", "Are there cells with abnormal morphology present in regions showing signs of fibrosis or carcinogenesis?", "Can you observe an accumulation of cells in the liver following severe or chronic hepatic injury, or in experimental regeneration models?", "Do any cells exhibit altered staining properties in areas corresponding to activation, differentiation, or pathological stimuli?", "Is there a population of cells with an increased nuclear-to-cytoplasmic ratio in regions suggestive of malignant transformation or high proliferative activity?", "Are there clusters of cells showing increased proliferation in response to liver injury, especially where replication of the main parenchymal cells appears suppressed?", "Can you detect cells with atypical cytoplasm in areas displaying features of dysplasia or neoplastic transformation?", "Are there cells containing vacuoles in regions that might be experiencing cellular stress, degeneration, or metabolic disturbance?", "Do any cells display changes in marker expression in association with activation, lineage commitment, or disease progression?", "Is there evidence of multinucleated cells in areas affected by abnormal mitosis or cellular stress during liver pathology?", "Can you see cells with granular cytoplasm in regions undergoing activation, degeneration, or metabolic changes?", "Are there cells with altered surface characteristics in areas where differentiation or microenvironmental cues are likely present?", "Do any cells appear larger than normal in regions associated with activation, transformation, or pathological states?", "Is there a clustering of cells in regions of active regeneration or chronic injury within the liver?", "Can you identify an increased number of mitotic figures among cells in areas of rapid proliferation following liver damage?", "Are there cells with altered chromatin patterns in regions suggestive of neoplastic transformation or high-grade dysplasia?", "Do any cells appear more resistant to staining in areas affected by cellular degeneration or altered membrane properties?"], "properties": ["Is there a cell in the image that measures approximately 10 to 15 micrometers in length?", "Can you identify a cell with an average diameter close to 10 micrometers?", "Does the image show a cell with an elongated, ovoid shape?", "Is there a cell that appears basophilic or blue-purple under standard staining?", "Can you find a cell displaying a high nuclear-to-cytoplasmic ratio?", "Is there a cell with scant cytoplasm and visible organelles such as mitochondria or endoplasmic reticulum?", "Does the image contain a mononuclear cell?", "Can you identify a cell expressing markers such as CK19, EpCAM, AFP, or OV6?", "Is there a cell with low cytoplasmic granularity?", "Does the image show a cell type that is typically transient and present for only days to weeks during liver injury?", "Can you find a diploid cell with normal somatic DNA content?", "Is there a cell expressing proteins characteristic of progenitor or biliary lineages, such as CK19, albumin, or AFP?", "Does the image contain a cell with moderate mitochondrial content?", "Can you identify a cell with a surface area estimated between 150 and 200 square micrometers?", "Is there a cell maintaining a membrane potential in the range of -40 to -60 millivolts, similar to other progenitor cells?"], "relational": ["Does the image show cells associated with the hepatic system?", "Can you identify cells located within the periportal area of liver tissue?", "Is there evidence of hepatic progenitor cells emerging in response to liver injury or regeneration?", "Does the image contain cells that are related to hepatocytes, cholangiocytes, or hepatic stellate cells?", "Are there cells interacting with bile ducts, hepatic sinusoids, or portal tracts?", "Can you see cells positioned near the canals of Hering in the periportal region?", "Is there a cell population closely connected to bile ducts, potentially differentiating into cholangiocytes?", "Does the image contain cells belonging to the hepatic progenitor cell lineage?", "Are there cells supported by or surrounded by the extracellular matrix, portal tracts, or sinusoidal endothelium?", "Can you identify progenitor cells structurally related to hepatic stem cells or ductular progenitor cells?"], "contexual_behavior": ["Is there evidence of increased progenitor cell proliferation in regions where hepatocyte replication appears impaired, such as after severe or chronic liver damage?", "Can you identify cells that show enhanced differentiation into hepatocytes in areas with signs of acute liver injury and regeneration?", "Does the image reveal reduced regenerative activity of progenitor cells in the presence of chronic liver disease or fibrotic changes?", "Are there regions where progenitor-mediated regeneration appears absent following toxic damage, suggesting disrupted activation or differentiation pathways?", "Is there increased proliferation and ductular reaction in response to biliary obstruction visible in the tissue?", "Do you observe a decrease in progenitor cell function in areas that may correspond to aging liver tissue?", "Is there evidence of impaired differentiation of progenitor cells in fibrotic regions, possibly due to extracellular matrix alterations?", "Can you see increased activity of progenitor cells in response to partial hepatectomy when hepatocyte proliferation seems insufficient?", "Are there visual cues indicating altered proliferation or differentiation patterns of progenitor cells in response to inflammatory cytokines or immune cell infiltration?", "Does the image show a lack of progenitor cell proliferation after exposure to toxins that might directly damage these cells or disrupt signaling pathways?", "Is there reduced contribution to tissue repair by progenitor cells in areas with advanced cirrhosis and extensive fibrosis?", "Can you identify increased progenitor cell involvement in liver regeneration following significant hepatocyte loss, such as after viral hepatitis?", "Are there signs of reduced regenerative function of progenitor cells in regions affected by oxidative stress or cellular damage?", "Is there a shift towards cholangiocyte differentiation by progenitor cells in areas with bile duct injury or cholestasis?", "Do you observe enhanced activation of progenitor cells in the context of metabolic liver diseases like nonalcoholic steatohepatitis?", "Is there a decrease in progenitor cell contribution to regeneration after repeated injury, possibly due to cell exhaustion or microenvironmental changes?", "Are there indications of impaired differentiation and reduced regenerative capacity of progenitor cells in regions with steatosis?", "Can you see increased progenitor cell activity in response to acute liver failure where massive hepatocyte loss is evident?", "Does the image suggest failed regeneration due to impaired stem cell signaling or disrupted activation and differentiation pathways?", "Are there areas where progenitor cells show increased proliferation or signs of malignant transformation following exposure to carcinogens?"], "functions": ["Does the image show cells that can give rise to both hepatocytes and bile duct cells?", "Is there evidence of progenitor cells contributing to the regeneration of liver tissue?", "Can you identify cells that proliferate in response to impaired hepatocyte replication?", "Does the image contain a cellular reservoir involved in replenishing damaged liver parenchyma?", "Are there cells visible that migrate toward sites of liver injury to aid in tissue recovery?", "Can you see cells participating in the formation of bile ducts by differentiating into ductal epithelium?", "Is there evidence of lineage commitment pathways leading to the generation of both hepatocytes and cholangiocytes?", "Are there cells contributing to the remodeling and regeneration of functional liver architecture?", "Does the image show cells interacting with the liver microenvironment, such as responding to signaling molecules or extracellular matrix components?", "Can you identify cells involved in modulating fibrogenic responses or interacting with hepatic stellate cells during liver fibrosis?", "Is there evidence of new functional hepatocytes and cholangiocytes being generated to restore liver function after damage?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an object in the image whose size could range from a few micrometers to several centimeters?", "Does the image contain an object whose mass could vary greatly depending on its size and composition?", "Can you identify an object whose consistency ranges from soft and pliable to firm and brittle?"], "relational": ["Does the image show an obstruction within a blood vessel such as an artery, vein, or capillary?", "Is there a sign of a material that could have originated from the heart and is now causing a blockage elsewhere in the circulatory system?", "Can you identify a blockage that could affect the lungs, brain, heart, or kidneys?"], "contexual_behavior": [], "functions": ["Is there a visible sign of tissue ischemia, such as pallor or discoloration, that might result from impaired blood supply?", "Does the image suggest tissue necrosis or infarction in an area supplied by a blocked vessel?", "Can you observe any signs of organ dysfunction or ischemic injury that could be linked to impaired perfusion?"]}}, "canals of hering": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears dilated, which could suggest cholestasis or an obstructive liver disease?", "Can you identify any features that appear narrowed, possibly indicating chronic inflammation or hepatic fibrosis?", "Does the image show increased cellularity in a region, which might be a response to liver injury or regeneration?", "Is there evidence of fibrosis in a duct-like structure, as seen in chronic liver diseases such as primary biliary cholangitis?", "Are there signs of inflammatory changes in a small duct, which could be associated with autoimmune or infectious cholangitis?", "Can you see any structures that appear obstructed or blocked, potentially due to bile duct obstruction or bile plugging?", "Is there visible proliferation of epithelial cells in a ductular region, suggestive of a ductular reaction or liver regeneration?", "Do you observe any changes in the diameter of a small duct, possibly reflecting altered bile flow or a pathological process?", "Are there accumulations of bile plugs in a canal-like structure, which could indicate cholestasis or bile stasis?", "Does the image show loss of normal architecture in a ductular area, as might occur in advanced liver disease or cirrhosis?", "Is there a region where duct-like structures appear more prominent, which could be a sign of ductular reaction or chronic liver injury?", "Can you identify deposition of abnormal material within a small duct, possibly related to metabolic liver disease or cholestatic disorders?", "Is there evidence of increased branching in a ductular network, which might be seen during regeneration or chronic injury?", "Do you see thickening of the walls of a small canal, which could be due to chronic inflammation or fibrosis?", "Are there regions where staining properties of a ductular structure are altered, as might be observed in cholestasis or during a ductular reaction?"], "properties": ["Does the image show a short, tubular, and branching structure with a diameter between 10 and 15 micrometers?", "Can you identify a structure that measures approximately 50 to 100 micrometers in length?", "Is there a feature lined by both hepatocytes and cholangiocytes?", "Can you see a transition in the epithelial lining from hepatocytes to cuboidal cholangiocytes?", "Does the image contain a structure with a wall thickness of about 1 to 2 micrometers?", "Is there a pale pink to eosinophilic staining pattern visible in a small tubular structure?", "Can you identify one or two such structures per liver lobule?", "Is there evidence of a structure with high water content, similar to other bile duct components?", "Does the image show a feature with moderate protein content, including cytokeratins and junctional proteins in its lining?", "Can you see a structure whose tissue density is similar to other soft tissues, around 1.05 g/cm\u00b3?", "Is there a visible extracellular matrix containing collagen types I and IV, laminin, and fibronectin?", "Can you identify a structure where the oxygen concentration is intermediate between portal blood and hepatocytes, approximately 30 to 40 mmHg?", "Is there evidence of a bile flow rate through a small duct at about 0.5 to 1.0 microliters per minute per gram of liver?", "Does the image show a structure with a neutral pH, close to 7.4?"], "relational": ["Does the image show a structure that is part of the hepatobiliary system?", "Can you identify a feature located within the liver that connects bile canaliculi to interlobular bile ducts?", "Is there a conduit visible between bile canaliculi and interlobular bile ducts?", "Does the image contain a region lined by both cholangiocytes and hepatocytes?", "Can you see a structure situated in the periportal region or portal tract of the liver?", "Is there an anatomical feature that receives bile from bile canaliculi?", "Does the image show a structure that drains into interlobular bile ducts?", "Can you identify a region in the periportal area of the liver associated with bile transport?", "Is there a visible connection between hepatic lobules and portal triads within the biliary system?"], "contexual_behavior": [], "functions": ["Does the image show a structure that acts as a transitional duct for bile conduction between hepatocytes and the bile duct system?", "Can you identify a conduit that channels bile from canaliculi into interlobular bile ducts?", "Is there an anatomical bridge visible that connects bile canaliculi with intrahepatic bile ducts?", "Does the image contain a feature that regulates bile flow by providing a controlled passage between small canaliculi and larger bile ducts?", "Can you see a region that could serve as a niche for hepatic progenitor cells involved in liver regeneration?", "Is there a specialized microenvironment present that supports the maintenance and activation of hepatic progenitor cells?", "Does the image show a structure that could supply progenitor cells for liver repair or repopulation of damaged hepatic or biliary tissue?", "Can you identify a feature that helps preserve the integrity and continuity of the biliary system by linking hepatocytes to bile ducts?"]}, "no_questions": {"contexual_properties": ["Is there visual indication of metastatic spread involving the lining of the abdominal cavity and affecting female reproductive structures?", "Can you identify any lesions or nodules present on the serosal surfaces of pelvic organs?", "Does the image show evidence of abnormal tissue growth on the outer surfaces of reproductive organs such as the uterus or ovaries?"], "properties": ["Can you identify lesions or nodules attached to the serosal layer of the uterus?", "Is there evidence of pathological implants on the outer surface of the ovaries?", "Are there visual signs of disease affecting both the uterus and ovaries at their outermost layers?"], "relational": ["Are there visible abnormalities in regions like the pouch of Douglas or the uterovesical pouch?", "Does the image reveal changes on the uterine or ovarian surfaces consistent with involvement of the pelvic peritoneum?", "Does the image show involvement of anatomical boundaries such as the broad ligament or mesovarium?"], "contexual_behavior": ["Can you identify any lesions or nodules present on the serosal lining of pelvic organs?", "Does the image reveal any irregularities or masses on the surfaces of organs within the pelvic cavity?", "Is there visual indication of metastatic deposits on the peritoneal surfaces adjacent to female reproductive structures?"], "functions": ["Does the image show signs of edema or vascular compromise near the serosal surfaces of pelvic organs?", "Does the image suggest the presence of immune cell infiltration or inflammation in the peritoneal cavity?", "Is there visual indication of mechanical compression or inflammation impacting the function of reproductive organs?"]}}}
[ { "answer": "foci of fat necrosis", "extracted_concepts": [ "areas of white chalky deposits", "foci of fat necrosis" ], "question": "what do the areas of white chalky deposits represent?" }, { "answer": "with calcium soap formation (saponification)", "extracted_concepts": [ "calcium soap formation", "saponification", "foci of fat necrosis", "white chalky deposits" ], "question": "how do the areas of white chalky deposits represent foci of fat necrosis?" }, { "answer": "yes", "extracted_concepts": [ "areas of white chalky deposits", "calcium soap formation", "sites of lipid breakdown", "foci of fat necrosis", "mesentery" ], "question": "do the areas of white chalky deposits represent foci of fat necrosis with calcium soap formation at sites of lipid breakdown in the mesentery?" }, { "answer": "no", "extracted_concepts": [ "calcium soap formation", "histone subunits", "sites of lipid breakdown", "foci of fat necrosis", "mesentery" ], "question": "do the histone subunits represent foci of fat necrosis with calcium soap formation at sites of lipid breakdown in the mesentery?" }, { "answer": "the areas of white chalky deposits", "extracted_concepts": [ "calcium soap formation", "white chalky deposits", "sites of lipid breakdown", "foci of fat necrosis", "mesentery" ], "question": "what represent foci of fat necrosis with calcium soap formation at sites of lipid breakdown in the mesentery?" }, { "answer": "at sites of lipid breakdown in the mesentery", "extracted_concepts": [ "calcium soap formation", "white chalky deposits", "sites of lipid breakdown", "foci of fat necrosis", "mesentery" ], "question": "where do areas of white chalky deposits represent foci of fat necrosis with calcium soap formation?" } ]	["saponification", "areas of white chalky deposits", "calcium soap formation", "white chalky deposits", "histone subunits", "foci of fat necrosis", "mesentery", "sites of lipid breakdown"]	{"saponification": {"yes_questions": {"contexual_properties": ["Does the image show areas where fat appears to have undergone necrosis, possibly with visible deposits?", "Can you identify regions with white or pale chalky deposits within tissue, suggesting a reaction with calcium?", "Is there evidence of firmer or less elastic tissue where fat would normally be present?", "Do you observe opaque regions in the tissue matrix that could indicate the accumulation of insoluble soaps?", "Are there larger zones of fat necrosis that might be associated with extensive injury or pancreatitis?", "Can you see tissue areas with altered color or texture, possibly due to the replacement of fat by soap deposits?", "Is there an increase in the mass or density of tissue where mineral or soap deposits have accumulated?", "Do microscopic features include amorphous basophilic deposits or ghost-like outlines of fat cells?", "Is there a loss of normal tissue elasticity in regions where rigid deposits have formed?", "Can you identify tissue changes that might result from elevated temperature or high alkali concentration?", "Are there signs of increased calcium content or binding within areas of fat necrosis?", "Do you observe any variation in deposit appearance that could be due to different types of fatty acids or metal ions?"], "properties": ["Does the image show a process or setup where the temperature appears to be maintained between 40\u00b0C and 80\u00b0C?", "Is there evidence of a reaction environment with a pH likely between 10 and 14?", "Can you identify a process that might require 30 to 60 minutes to complete?", "Does the image display products that could include both a solid (such as a white or off-white substance) and a liquid phase?", "Is there a visible indication of a chemical reaction involving a 1:1 ratio of triglyceride to alkali?", "Can you see evidence suggesting a high yield (between 90% and 98%) of a solid product?", "Does the setup appear to use an alkali concentration in the range of 10% to 20% by weight?", "Is there a solid product present that could have a density between 0.8 and 1.1 g/cm\u00b3?", "Can you observe a solid substance whose melting point might be in the range of 100\u00b0C to 130\u00b0C?", "Does the image show a product mixture where the solid phase could contain 60% to 80% fatty acids by weight?", "Is there a liquid component that could represent 8% to 12% of the total product mixture?", "Can you see a process or apparatus that might release a mild amount of heat, consistent with an enthalpy change of \u201350 to \u2013100 kJ/mol?", "Is there a solid product whose color is white or off-white, possibly influenced by the starting materials?", "Does the image suggest a final product with a water content of 10% to 30% before drying?"], "relational": ["Does the image show evidence of a chemical process occurring in fatty tissue where triglycerides might react with calcium to form soap-like deposits?", "Can you identify any abnormal changes in the pancreas or subcutaneous regions that could indicate a reaction between adipose tissue and calcium?", "Is there a visible area in the abdominal cavity or peripancreatic region that appears to contain calcified or soap-like material?", "Does the image reveal any tissue changes suggestive of fat necrosis, especially in association with pancreatic injury or trauma?", "Are there signs of tissue calcification, inflammation, or fibrosis within fatty or subcutaneous tissues?", "Can you see any regions where adipocytes or macrophages appear to be involved in a pathological process with calcium ions?", "Is there evidence of a process affecting the digestive, integumentary, or endocrine systems that could be linked to fat necrosis or tissue calcification?", "Does the image show any structural changes in the breast or subcutaneous fat that might be associated with the formation of calcium soaps?", "Are there visual cues indicating the presence of acute pancreatitis with associated fat necrosis or calcification?"], "contexual_behavior": ["Does the image show evidence of increased pathological calcification within adipose tissue, suggesting the formation of insoluble deposits?", "Is there any indication of fat necrosis in association with acute inflammation of the pancreas, which could lead to enhanced soap formation?", "Can you identify features that might suggest tissue trauma, such as disrupted cell membranes, which could facilitate the formation of soaps?", "Does the image reveal changes in postmortem tissues, such as areas of fat breakdown and soap-like deposits?", "Is there visual evidence of impaired fat breakdown, such as reduced soap formation, that might be consistent with pancreatic enzyme deficiency?", "Can you see signs that might indicate chronic liver disease, such as impaired bile production, which could reduce the breakdown and saponification of fats?", "Is there any indication of altered mineral deposition, such as the presence of magnesium-containing soaps with different texture or solubility compared to calcium deposits?", "Does the image suggest tissue dehydration, which could result in less efficient fat hydrolysis and reduced soap formation?", "Are there features consistent with hypothermic tissue, where reduced enzymatic activity might lead to inefficient fat breakdown and soap formation?", "Can you identify areas where excessive fat accumulation might provide more substrate for enzymatic breakdown and increased soap formation?", "Is there evidence of low calcium availability, such as decreased or absent insoluble soap deposits in fatty tissues?", "Does the image suggest a low pH environment, which could inhibit the reaction between fatty acids and bases and reduce soap formation?", "Are there visual cues indicating the presence of strong alkali, which could promote the hydrolysis of triglycerides and enhance soap formation?", "Can you detect signs of impaired lipase activity, such as a lack of free fatty acids and reduced soap deposits in fatty tissues?", "Is there any indication that a high concentration of fatty acids is present, which could accelerate the formation of soaps in the tissue?"], "functions": ["Does the image show evidence of a chemical reaction where fatty acids have combined with calcium to form insoluble deposits?", "Can you identify areas where fat breakdown has resulted in the formation of soap-like substances within tissue?", "Is there visual evidence of tissue changes consistent with fat necrosis, such as chalky or white deposits?", "Does the image display features suggesting the conversion of triglycerides or free fatty acids into insoluble materials in the presence of calcium?", "Are there visible deposits that could indicate the sequestration of fatty acids as calcium soaps within tissue?", "Can you see signs of tissue injury or necrosis associated with the formation of white, chalky material?", "Is there evidence of pathological calcification in organs such as the pancreas or breast, characterized by soap-like deposits?", "Does the image reveal areas where fatty acids appear to be immobilized as insoluble substances, possibly reducing local toxicity?", "Can you identify regions where the tissue response to injury includes the deposition of soap-like material?", "Is there a visible hallmark of fat necrosis, such as the transformation of released fatty acids into calcium-rich deposits?", "Does the image show tissue changes that could result from the precipitation of fatty acids with calcium, forming visible deposits?", "Are there features suggesting the emulsification or breakdown of fats beyond normal enzymatic digestion, possibly involving chemical soap formation?", "Can you see evidence of fat hydrolysis followed by the formation of insoluble calcium-containing material in the tissue?", "Is there a region where the removal or sequestration of fatty acids has led to the accumulation of chalky deposits?", "Does the image contain signs of detoxification of fatty substances through their conversion into insoluble, soap-like forms?"]}, "no_questions": {"contexual_properties": ["Can you identify any signs of posterior or superior displacement of a bony structure that might reduce the diameter of the foramen magnum?", "Are there signs of altered cerebrospinal fluid pathways due to narrowing at the foramen magnum?", "Does the image reveal any compression or impingement on the brainstem or upper spinal cord?"], "properties": ["Does the angulation of a bony process relative to the base of the skull exceed 110 degrees?", "Does the MRI show a region of hyperintensity on T2-weighted images in the upper cervical area, possibly indicating edema or myelopathy?", "Is there a structure with an abnormal, tilted, malformed, or hypoplastic appearance in the upper cervical region?"], "relational": ["Does the articulation between the axis and the occipital bone appear abnormal in the image?", "Is there evidence of reduced space for the vertebral arteries as they pass through the foramen magnum?", "Does the image show any abnormal alignment between the first and second cervical vertebrae?"], "contexual_behavior": ["Does the image show evidence of abnormal alignment between the first and second cervical vertebrae?", "Does the image reveal any relationship between cervical vertebral misalignment and reduced space for neural structures at the craniovertebral junction?", "Is there visible narrowing of the opening at the base of the skull through which the spinal cord passes?"], "functions": ["Can you see anatomical changes that might affect respiratory centers in the medulla or descending respiratory pathways?", "Does the image show signs consistent with myelopathy, such as changes in the spinal cord or altered reflex pathways below the craniovertebral junction?", "Does the image suggest possible disruption of motor or sensory pathways, potentially resulting in weakness or sensory loss?"]}}, "areas of white chalky deposits": {"yes_questions": {"contexual_properties": ["Does the image show any regions that appear larger than others, possibly indicating progression of fat necrosis or calcification?", "Are there areas that seem to have decreased in size, suggesting healing or reabsorption by the body?", "Can you identify multiple similar regions, which might indicate disease spread or multifocal tissue injury?", "Are there any regions that have changed color, possibly due to infection, hemorrhage, or changes in the local tissue environment?", "Do any areas appear firmer or denser, which could suggest increased mineralization or calcification?", "Is there evidence of softening in any region, potentially due to enzymatic breakdown or inflammation?", "Can you see new regions appearing in locations that suggest recent tissue damage or necrosis?", "Are there areas that stand out more due to thinning of overlying tissue or increased local inflammation?", "Do any regions display a change in texture, possibly reflecting ongoing metabolic or inflammatory processes?", "Are there areas that are less visible, perhaps due to reabsorption, tissue regeneration, or reduced density?", "Can you identify regions that appear denser, which might be due to additional calcium or mineral accumulation?", "Are there areas that seem less dense, possibly indicating mineral loss or partial dissolution?", "Is there visible evidence of inflammation, such as swelling or redness, around any of these regions?", "Do any areas appear surrounded by redness, suggesting local inflammation or increased blood flow?", "Are there regions with irregular borders, which could indicate uneven pathological processes or tissue breakdown at the margins?", "Can you see signs of tissue breakdown, such as necrosis or ulceration, associated with any of these regions?", "Are there regions that appear to have undergone further calcification, possibly due to chronic inflammation or ongoing injury?", "Is there evidence that any of these regions have resolved or disappeared, suggesting spontaneous healing and reabsorption?", "Do any areas show changes in their internal composition, possibly due to metabolic or inflammatory shifts?", "Are there regions associated with signs of pain or tenderness, such as local swelling or secondary infection?"], "properties": ["Does the image show any regions that appear white or off-white in color?", "Can you identify any areas with a dry, brittle, or powdery texture?", "Are there any structures that look irregular, amorphous, or form nodules or plaques?", "Is there a region that appears matte, non-reflective, or has a granular surface?", "Can you see any deposits that are opaque or highly opaque compared to surrounding tissues?", "Are there areas whose size ranges from a few millimeters to several centimeters?", "Is there a structure whose thickness appears less than a few millimeters?", "Can you identify any regions that might have a relatively low density compared to bone?", "Do any deposits appear to have a moderate hardness, similar to a Mohs hardness of 3?", "Is there evidence of a region with high calcium content, possibly exceeding 30% by weight?", "Can you see any deposits that might contain phosphate or traces of magnesium?", "Are there areas that seem to have low water content, appearing especially dry?", "Do any regions have a neutral to slightly alkaline appearance or context?"], "relational": ["Does the image show any regions within adipose tissue or pancreatic parenchyma that appear abnormal?", "Can you identify any features in the digestive, musculoskeletal, or cardiovascular systems that might indicate a pathological process?", "Is there evidence of abnormal deposits in the pancreas, subcutaneous tissue, or arteries?", "Are there structures adjacent to blood vessels, connective tissue, or epithelial layers that appear altered?", "Can you see areas where macrophages, fibroblasts, or necrotic cells might be present?", "Is there visual evidence of fibrosis, inflammation, or encapsulation in the surrounding connective tissue?", "Does the image show any changes in the pancreas, heart, or kidneys that could suggest a pathological process?", "Are there regions where tissue architecture, vascular integrity, or cellular composition appear disrupted?", "Can you identify areas where blood, interstitial fluid, or lymph might be interacting with abnormal deposits?", "Is there a visible structure resembling a calcified plaque, infarct, or tumor mass that contains distinct regions?"], "contexual_behavior": ["Does the image show regions that have increased in size in association with ongoing cell death or persistent calcium release?", "Can you identify areas that appear more prominent in the context of chronic inflammation or sustained tissue damage?", "Is there evidence of deposits that have not resolved despite apparent treatment, suggesting an unresolved underlying cause such as abnormal calcium metabolism?", "Do any regions seem to have decreased following restoration of normal calcium and phosphate balance?", "Are there features present that could be impairing tissue function, possibly related to a metabolic disorder involving calcium or phosphate dysregulation?", "Can you see accumulations that are more pronounced in areas where blood flow may be reduced, indicating possible ischemia and necrosis?", "Is there visual evidence of deposits that could be interfering with organ function in the setting of elevated circulating calcium levels?", "Do any areas appear less prominent after what might be correction of an underlying disease or normalization of metabolic processes?", "Are there regions that have increased in association with prolonged tissue necrosis or ongoing cell death?", "Can you observe changes in the appearance of deposits that might correspond to alterations in local pH or tissue environment affecting calcium salt solubility?"], "functions": ["Does the image show any regions where tissue appears stiffened or less elastic compared to surrounding areas?", "Can you identify areas that might disrupt normal nutrient exchange or cellular signaling within the tissue?", "Is there evidence of local tissue damage or impaired organ function that could be linked to mineral accumulation?", "Does the image contain regions that could trigger an inflammatory response, such as areas with immune cell infiltration?", "Are there visible signs of tissue rigidity or brittleness that might indicate altered mechanical properties?", "Can you see any areas where healing appears delayed or where tissue regeneration seems impaired?", "Is there evidence of obstruction or decreased compliance in an organ that could be caused by abnormal deposits?", "Do you observe any features suggesting metabolic impairment or reduced oxygen delivery to cells in a specific region?", "Are there regions that might contribute to chronic inflammation or ongoing tissue degeneration?", "Can you identify areas where normal enzymatic activity could be inhibited due to changes in the local biochemical environment?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there an organ located adjacent to the bladder or rectum?", "Does the image contain a structure positioned near the ovaries?", "Is there a visible anatomical connection between a structure and the vagina?"], "contexual_behavior": [], "functions": ["Does the image show a structure essential for fertility, pregnancy support, or menstrual health?", "Is there evidence of an organ that expands during pregnancy to accommodate a growing fetus?", "Can you see a tissue that supplies nutrients and removes waste for fetal development?"]}}, "calcium soap formation": {"yes_questions": {"contexual_properties": ["Does the image show areas within tissues that appear chalky-white or have a gritty texture, suggesting the presence of saponification?", "Can you identify regions that appear firmer or harder than surrounding tissue, possibly due to calcification in necrotic fat?", "Are there visible macroscopic deposits or radiopaque areas that could indicate increased radiodensity from calcified fat?", "Does the image reveal any palpable masses or nodules that might result from fat necrosis and calcium accumulation?", "Is there evidence of tissue remodeling where normal fat seems to be replaced by denser, insoluble material?", "Can you observe changes in tissue appearance that might be associated with chronic inflammation or acute pancreatitis?", "Are there signs of increased density or radiopacity in regions where fat breakdown and saponification may have occurred?", "Does the image suggest the presence of fat necrosis, such as areas of altered texture or color within fatty tissue?", "Can you see any features that might regress or resolve with treatment, such as reduction in size or disappearance of dense deposits?", "Is there visual evidence of organ involvement where abnormal deposits are present in association with tissue injury or disease progression?"], "properties": ["Does the image show granular or chalky deposits within tissue?", "Can you identify any structures with a white or pale yellow color?", "Is there evidence of amorphous or microcrystalline material present?", "Do you see deposits ranging in size from micrometers to several millimeters?", "Are there firm, gritty, or chalky textures visible in the tissue?", "Can you find deposits that might be insoluble in water?", "Is there a structure with a density similar to 1.3 to 1.4 g/cm\u00b3?", "Are there deposits located in areas of necrotic fat, such as the pancreas or subcutaneous tissue?", "Do you observe material that could form at a neutral to slightly alkaline pH, around 7.0 to 8.5?", "Is there evidence of deposits with high concentrations of calcium and fatty acids?", "Can you see material with a refractive index likely between 1.47 and 1.52?", "Are there deposits with a hardness similar to soft chalk?"], "relational": ["Does the image show evidence of fat necrosis in tissues such as the pancreas or subcutaneous regions?", "Can you identify any nodules or lesions within adipose tissue that might indicate saponification?", "Is there a visible structure in the abdominal cavity or breast that could be associated with mineral deposits like dystrophic calcification?", "Does the image contain areas where adipocytes or necrotic cells are present alongside calcified material?", "Can you see any features suggestive of lipase activity leading to saponification within fatty tissue?", "Is there a region in the digestive or integumentary system displaying signs of fat necrosis nodules or calcified lesions?", "Does the image include pancreatic tissue with evidence of pseudocyst formation or calcification?", "Can you identify any interaction between the pancreas, liver, and surrounding adipose tissue that might indicate a pathological process?", "Are there deposits resembling calcium phosphate within areas of fat necrosis?", "Is there a structure in the subcutaneous tissue or breast that could be associated with the formation of calcium-containing soaps?"], "contexual_behavior": ["Does the image show evidence of increased binding between unabsorbed fatty acids and calcium ions in the intestine, which might occur during fat malabsorption?", "Is there a visual indication of reduced soap-like deposits in the gut that could suggest low dietary calcium intake during fat malabsorption?", "Can you identify features consistent with impaired fat digestion due to reduced pancreatic enzyme activity, as might be seen in pancreatic insufficiency?", "Does the image suggest an increase in unabsorbed fatty acids reacting with calcium, possibly due to excess dietary fat?", "Is there evidence of decreased unabsorbed fatty acids in the intestine, as might be expected after bile acid supplementation?", "Can you see signs of persistent fat malabsorption and elevated unabsorbed fatty acids in the gut, as might occur in chronic pancreatitis?", "Does the image suggest reduced formation of insoluble deposits due to low dietary calcium intake?", "Is there visual evidence of large amounts of unabsorbed fat in the stool, which could promote the formation of insoluble complexes with intestinal calcium as seen in steatorrhea?", "Can you identify changes in the intestinal lining that might indicate altered absorption of fat and calcium, such as those seen in intestinal inflammation?", "Does the image show accumulation of unabsorbed fatty acids in the intestinal lumen, as might be found in fat digestion disorders?", "Is there a reduction in unabsorbed fatty acids in the gut, possibly following enzyme replacement therapy?", "Can you observe features that might reflect changes in the solubility or binding of fatty acids with calcium due to altered gut pH?", "Is there evidence of villous atrophy in the intestine, which could lead to increased unabsorbed fatty acids as seen in celiac disease?", "Does the image suggest reduced absorptive surface area in the intestine, as might occur after surgical resection, potentially leading to decreased formation of insoluble complexes?", "Can you identify features consistent with severe fat malabsorption and high levels of unabsorbed fatty acids in the gut, as might be seen in cystic fibrosis with pancreatic enzyme deficiency?"], "functions": ["Is there evidence of a process in the gastrointestinal tract where free fatty acids are bound to calcium ions, resulting in insoluble compounds?", "Can you identify any indication of impaired fat digestion due to the formation of insoluble complexes that prevent fatty acid absorption?", "Does the image suggest the sequestration of long-chain fatty acids within the gut, potentially limiting their uptake?", "Is there visual evidence of decreased fatty acid absorption, such as the presence of non-absorbable soaps destined for fecal excretion?", "Can you observe features that might indicate an increase in fecal fat excretion, such as signs consistent with steatorrhea?", "Is there any indication of altered mineral balance, possibly due to reduced bioavailability of dietary calcium and fatty acids?", "Does the image suggest a process that regulates lipid metabolism by limiting the intestinal absorption of dietary fats?", "Can you see signs that dietary fat bioavailability is reduced because of the formation of insoluble complexes in the gut?", "Is there evidence of a mechanism that prevents fat absorption by binding fatty acids and reducing their intestinal uptake?", "Does the image show any interaction with bile acids that could indicate competition for fatty acids, potentially disrupting micelle formation and interfering with digestion?"]}, "no_questions": {"contexual_properties": ["Can you see color changes within a lesion, such as areas of hemorrhage, necrosis, or increased vascularity?", "Does the structure display increased fibrous tissue or a desmoplastic stromal response?", "Can you observe changes in consistency or firmness of the lesion, potentially due to fibrosis, necrosis, or calcification?"], "properties": ["Is there moderate to abundant stromal tissue, possibly due to a desmoplastic reaction?", "Does the image show a region composed of gland-forming epithelial cells, fibroblasts, and inflammatory cells?", "Is there a region with a noticeably high proliferation rate compared to adjacent tissue?"], "relational": ["Can you see a region where normal tissue boundaries of glandular epithelium are disrupted or lost?", "Is there visual evidence of invasion into adjacent organs or spread to lymph nodes or distant sites?", "Does the image show a lesion affecting glandular epithelium or submucosal tissue?"], "contexual_behavior": ["Does the structure display altered metabolic activity, such as increased glycolysis, which might occur during hypoglycemia or use of alternative energy sources?", "Can you see evidence of immune evasion, such as reduced antigen presentation or increased expression of immune checkpoint molecules, especially in an immunosuppressed environment?", "Can you observe changes in the secretory profile, such as altered cytokine or growth factor secretion, in response to the tumor microenvironment?"], "functions": ["Can you see signs of inflammation or changes in the local tissue environment near the abnormal growth?", "Is there visual evidence of tissue invasion or local spread into surrounding structures?", "Is there evidence of vascular or lymphatic invasion that could indicate potential for metastatic spread?"]}}, "white chalky deposits": {"yes_questions": {"contexual_properties": ["Does the image show any areas that appear larger due to ongoing accumulation of calcium or urate salts?", "Are there multiple regions that could indicate persistent metabolic or inflammatory processes such as chronic gout or soft tissue calcification?", "Can you identify any regions where a change in color suggests secondary infection, hemorrhage, or chemical alteration?", "Is there evidence of hardening in certain areas that might result from progressive mineralization or crystal growth?", "Do any regions appear softened, possibly due to local enzymatic activity, inflammation, or medical treatment?", "Are there new locations in the image where abnormal material has appeared, suggesting disease progression or systemic metabolic imbalance?", "Can you observe a decrease in the amount of abnormal material, potentially indicating effective therapy or disease resolution?", "Are there areas that look more prominent because of thinning overlying tissues, increased inflammation, or growth of the abnormal material?", "Is there visual evidence of dissolution, such as reduction in size or disappearance of abnormal material, possibly due to chelation therapy or restored metabolic balance?", "Do you see changes in the appearance of deposits that could be attributed to shifts in calcium or uric acid levels?", "Are there signs of local inflammation or tissue injury associated with the abnormal material, suggesting immune activation or crystal-induced inflammation?", "Can you identify structures that would be visible on radiographic imaging due to sufficient size or density?", "Are there regions with irregular borders, possibly resulting from partial resorption, fragmentation, or infiltration by inflammatory cells?", "Do any areas appear denser, consistent with mineral accumulation or maturation of the abnormal material?", "Are there regions where the abnormal material is less distinct, perhaps due to partial dissolution, surrounding edema, or soft tissue reaction?"], "properties": ["Does the image show any structures that appear white in color?", "Can you identify any areas with a chalky, brittle, or powdery texture?", "Is there evidence of deposits that could be composed of minerals such as calcium phosphate or calcium carbonate?", "Are there any granular, irregular, or nodular formations visible?", "Can you see any objects that might have a crystalline or microcrystalline appearance, such as hydroxyapatite or calcite?", "Is there a structure whose density could be consistent with that of calcium salts, around 2.7 g/cm\u00b3?", "Are there deposits that might have a hardness of approximately 3\u20135 on the Mohs scale?", "Can you identify any formations that are likely to be slightly soluble or insoluble in water?", "Is there a visible deposit that could have a high calcium content, possibly exceeding 30% by weight?", "Are there any objects that might contain significant phosphorus, as would be expected if calcium phosphate is present?", "Can you see any deposits that are likely to have low to moderate magnesium content?", "Are there structures whose size ranges from micrometers to several centimeters?", "Is there evidence of masses that could weigh from milligrams to several grams?", "Do any of the visible deposits have a neutral to slightly alkaline appearance, as might be inferred from their context?"], "relational": ["Does the image show any abnormal material within joints, kidneys, skin, or heart valves?", "Can you identify any changes in tendons, subcutaneous tissue, or synovial membranes that might indicate an underlying pathological process?", "Is there evidence of involvement of the musculoskeletal, renal, integumentary, or cardiovascular systems by abnormal deposits?", "Are there visible alterations in periarticular areas, fingers, elbows, or ears that could suggest a localized pathological process?", "Can you see any clusters of cells such as macrophages, fibroblasts, lymphocytes, or giant cells near abnormal deposits?", "Is there a region where abnormal material appears to be associated with collagenous structures or the extracellular matrix?", "Are there any blood vessels, nerves, or muscle fibers adjacent to abnormal deposits in the image?", "Does the image show structural changes in organs like the kidneys, heart, skin, or joints that could be due to abnormal deposits?", "Can you identify firm nodules, areas of discoloration, or calcified masses that distinguish certain regions from the surrounding tissue?", "Is there evidence of larger pathological structures such as tophi, calcified plaques, or dystrophic calcifications that might contain abnormal deposits?"], "contexual_behavior": ["Does the image show evidence of tissue injury where abnormal mineral accumulation is present?", "Is there a region in the image that suggests dystrophic calcification in damaged or necrotic tissues?", "Can you identify any deposits that might be more prominent in the context of chronic kidney disease?", "Is there visual evidence of abnormal accumulation that could be linked to impaired phosphate excretion or secondary hyperparathyroidism?", "Does the image contain deposits that may have formed rapidly in response to elevated calcium levels?", "Can you see any abnormal mineralization in otherwise healthy tissues that could suggest metastatic calcification?", "Is there a reduction in abnormal deposits that might indicate correction of a metabolic imbalance or normalization of calcium levels?", "Does the image show any features that could impair joint function, such as accumulation of monosodium urate crystals?", "Is there evidence of joint inflammation or reduced mobility due to crystal deposition?", "Can you identify any changes that might suggest a response to medical intervention, such as therapy-induced reduction of abnormal deposits?", "Are there areas of soft tissue with increased abnormal mineralization that could be associated with metabolic disorders like hyperparathyroidism or pseudogout?", "Does the image show impaired wound healing or chronic inflammation in the skin due to abnormal mineral accumulation?", "Is there evidence of organ dysfunction or calcification that could be related to systemic diseases such as systemic sclerosis or chronic renal failure?", "Can you see more prominent abnormal deposits in regions that appear to have experienced trauma or tissue necrosis?", "Is there visual evidence of vascular dysfunction, such as stiffened vessel walls, that could be due to calcific vasculopathy?", "Are there fewer abnormal deposits in areas where dietary modification or metabolic control may have reduced serum calcium or uric acid levels?", "Does the image suggest increased abnormal mineralization in association with autoimmune conditions or connective tissue diseases?", "Is there evidence that abnormal deposits are interfering with normal enzymatic activity or disrupting the local biochemical environment in tissues?"], "functions": ["Does the image show evidence of mineral precipitation within tissues?", "Can you identify areas that might indicate dystrophic or metastatic calcification?", "Is there a region that could be causing mechanical obstruction or reduced elasticity in the tissue?", "Does the image reveal signs of cellular damage potentially linked to abnormal mineral accumulation?", "Are there features suggesting chronic inflammation or ongoing pathology in the tissue?", "Can you see any evidence of immune cell recruitment or local tissue irritation?", "Does the image display patterns consistent with macrophage activation, fibrosis, or granuloma formation?", "Is there a structure that appears to be causing obstruction or loss of compliance in an organ?", "Can you identify areas where functional decline of tissue might be occurring?", "Are there visual cues of cellular stress or impaired nutrient exchange in the affected region?", "Does the image suggest mitochondrial dysfunction or altered cellular metabolism in certain areas?", "Can you see signs of phagocytosis or an inflammatory response in the tissue?", "Is there evidence of calcium salt accumulation or matrix mineralization leading to tissue hardening?", "Does the image show features that could contribute to delayed tissue repair or persistent tissue damage?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Are there visible differences in the ribs or spine that could suggest a connective tissue disorder?", "Does the image show any abnormalities in vascular tissue that could indicate altered elasticity?", "Can you see any joint abnormalities, such as hypermobility or unusual structure in the knees, elbows, fingers, or wrists?"], "contexual_behavior": ["Is there evidence of worsened aortic dilation during pregnancy, possibly due to increased blood volume and cardiac output?", "Is there a visible indication of increased risk for aortic dissection, especially in the context of physical exertion or elevated blood pressure?", "Is there evidence of altered cardiovascular function, such as aortic dilation or dissection, in the presence of hypertension?"], "functions": ["Does the image reveal decreased elasticity or fragility in blood vessels, making them appear more susceptible to dilation or rupture?", "Can you observe signs of ocular abnormalities, such as lens displacement or indications of nearsightedness?", "Can you see abnormalities in heart valve structure or function, such as prolapse or regurgitation of the mitral valve?"]}}, "histone subunits": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a cellular compartment where chromatin is present?", "Is there a structure within the nucleus that could contain nucleosomes?", "Can you identify a region where protein complexes such as histone octamers might be assembled?", "Does the image contain evidence of chromatin structure?", "Is there a visible area where DNA might interact with protein complexes?", "Can you see any indication of macromolecular assemblies that organize into chromosomes?", "Is there a compartment where chromatin remodeling complexes or histone chaperones could be active?", "Does the image show a region likely to contain both histone and non-histone chromosomal proteins?", "Is there a structure that could be composed of repeating units fundamental to chromatin organization?", "Can you identify a cellular region where higher-order chromatin fibers might be observed?"], "contexual_behavior": [], "functions": ["Does the image show structures that are involved in organizing and stabilizing DNA within the nucleus?", "Can you identify components that form the core of nucleosomes around which DNA is wrapped?", "Is there evidence of elements essential for establishing higher-order chromatin structure?", "Does the image display features related to the assembly of nucleosomes?", "Can you see any indication of structures that undergo chemical modifications such as methylation or acetylation to regulate gene activity?", "Is there visual evidence of components involved in epigenetic regulation or transcriptional control?", "Does the image contain features that participate in DNA repair by providing recognition sites for repair proteins?", "Can you identify structures that facilitate chromatin remodeling to allow access to damaged DNA?", "Is there evidence of elements that control chromatin condensation during the cell cycle?", "Does the image show features that might be involved in chromosome segregation or chromosome dynamics?", "Can you see structures that modulate DNA accessibility for transcription by altering nucleosome positioning?", "Is there visual evidence of scaffolds around which DNA is wound for nucleosome formation?", "Does the image contain features that interact with chromatin remodeling complexes to regulate chromatin structure?", "Can you identify components that help maintain genome stability by protecting DNA from damage?", "Is there evidence of elements ensuring proper chromosome structure and genome integrity?"]}, "no_questions": {"contexual_properties": ["Can you observe variation in the number of nuclear bodies within the nucleus, possibly reflecting cell cycle progression, nucleolar fusion, or fragmentation?", "Are there nuclear bodies with increased density, possibly reflecting enhanced ribosomal biogenesis, oncogenic activity, or nucleolar stress?", "Do any nuclear features appear less visible in areas showing cellular differentiation, senescence, or after therapy response?"], "properties": ["Does the image show any round or oval structures within the nucleus that are approximately 1 to 5 micrometers in diameter?", "Do you observe distinct granular and fibrillar regions within any nuclear body?", "Is there a visible nuclear feature that could indicate a high concentration of nucleic acids, such as ribosomal RNA?"], "relational": ["Can you identify nuclear organizer regions or Cajal bodies in proximity to altered nucleoli?", "Can you identify neoplastic or tumor cells that contain distinctive nuclear features?", "Is there a relationship between the nucleus and endoplasmic reticulum or nuclear pore complex visible in cells with abnormal nucleoli?"], "contexual_behavior": ["Is there a structure that alters its function to facilitate viral replication or sequester viral proteins during viral infection?", "Does the image show a structure that increases ribosomal RNA synthesis during periods of rapid cell growth?", "Can you see changes in nucleolar structure or function in response to oxidative stress?"], "functions": ["Does the image show a nuclear structure involved in ribosome biogenesis?", "Is there evidence of a structure coordinating the maturation and modification of precursor rRNAs?", "Does the image show a nuclear component that sequesters specific proteins or RNAs, potentially modulating their nuclear availability?"]}}, "foci of fat necrosis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show any areas that range in size from a few millimeters to several centimeters?", "Can you identify regions with an irregular or nodular shape?", "Are there any structures that appear pale yellow or chalky white in color?", "Is there a visible area that looks firm or gritty in texture?", "Can you find regions that might contain necrotic adipocytes or inflammatory cells?", "Are there areas that could include calcified material?", "Does the image show clusters of macrophages, multinucleated giant cells, or neutrophils?", "Can you identify regions with high lipid content due to the breakdown of adipose tissue?", "Are there areas where calcium concentration might be elevated, possibly due to calcification?", "Do you see any regions with reduced water content compared to normal adipose tissue?", "Is there a structure that appears denser than surrounding fat, possibly due to cellular infiltration or calcification?", "Can you spot microscopic features such as disrupted fat cells, basophilic calcium deposits, or inflammatory infiltrate?", "Are there areas that might have a slightly acidic environment due to inflammation and cellular breakdown?", "Can you identify regions with elevated protein content, possibly from inflammatory exudate or cellular debris?", "Do you see evidence of calcification occurring with moderate to high frequency, especially in chronic-appearing lesions?", "Is there a single focus or are there multiple discrete lesions present in the tissue?"], "relational": ["Does the image show any regions within adipose or subcutaneous tissue that appear abnormal?", "Can you identify any changes in breast or abdominal fat tissue that might indicate tissue injury?", "Is there evidence of lesions associated with the digestive, integumentary, or endocrine systems?", "Are there any abnormal areas adjacent to connective tissue septa or blood vessels?", "Can you see clusters of cells such as macrophages or multinucleated giant cells within fatty tissue?", "Does the image reveal regions where neutrophils or adipocytes are present in an inflammatory context?", "Is there a visible lesion in the breast, pancreas, or omentum that could indicate tissue damage?", "Are there areas surrounded by fibrous tissue, collagen fibers, or inflammatory stroma within fatty regions?", "Can you identify any abnormality near capillaries or small arteries that suggests vascular injury or inflammation?", "Is there evidence of interaction between inflammatory cells, fibroblasts, or the extracellular matrix in fatty tissue?", "Does the image contain larger lesions such as pseudocysts or masses that might include areas of tissue breakdown?", "Can you see any features consistent with saponification lesions within fatty tissue?"], "contexual_behavior": [], "functions": ["Does the image show any regions where adipocyte death or localized tissue injury is apparent?", "Can you identify areas that might be undergoing tissue remodeling due to the clearance of necrotic fat cells?", "Is there evidence of local inflammation, such as the presence of cellular debris or signs of cytokine release?", "Are there regions where immune cells like macrophages or neutrophils appear to be recruited to a site of injury?", "Does the image reveal any areas where persistent inflammation or delayed tissue regeneration is visible?", "Can you see signs of adipose tissue breakdown, such as regions suggestive of lipolysis or phagocytosis of fat cells?", "Is there evidence of inflammatory mediator release, such as cytokines or chemokines, from damaged adipocytes or infiltrating immune cells?", "Are there any indications of microvascular injury, vascular dysfunction, or thrombosis in the surrounding tissue?", "Can you identify areas where fibrosis might be developing, such as regions with increased fibroblast activity or extracellular matrix deposition?", "Is there visual evidence of macrophage interaction with necrotic material or modulation of the inflammatory response in the tissue?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an object present that typically measures between 4 and 6 centimeters in length and 2 to 3 centimeters in width?", "Can you see a structure whose tissue pH might be between 7.2 and 7.4?", "Is there a structure that could contain specialized cells such as chromaffin cells or those from the zona glomerulosa, fasciculata, or reticularis?"], "relational": ["Does the image contain an object situated near the liver or diaphragm?", "Is there evidence of a gland receiving blood from the superior, middle, or inferior suprarenal arteries?", "Can you see a structure supported by renal fascia or surrounded by perirenal fat?"], "contexual_behavior": [], "functions": ["Is there a structure that helps regulate salt and water balance by controlling sodium reabsorption and potassium excretion?", "Does the image show an object that regulates blood sugar by stimulating gluconeogenesis and inhibiting insulin action?", "Is there an anatomical feature that influences blood pressure by affecting sodium and water retention in the kidneys?"]}}, "mesentery": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system and provides support to the small or large intestine?", "Can you identify a region that anchors the intestines to the posterior abdominal wall?", "Is there a visible structure through which major blood vessels, such as the superior mesenteric artery or vein, pass?", "Does the image contain a conduit for autonomic nerves, including branches of the vagus nerve or sympathetic fibers?", "Can you see lymphatic structures, such as mesenteric lymph nodes or lymphatic vessels, associated with the intestines?", "Is there a tissue layer that attaches to the jejunum, ileum, or colon?", "Does the image show layers composed of visceral peritoneum and connective tissue supporting the intestines?", "Can you identify areas containing loose areolar tissue or adipose tissue near the intestines?", "Is there a structure that serves as a pathway for blood vessels, nerves, and lymphatics to reach the intestines?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that suspends the intestines and maintains their position within the abdominal cavity?", "Can you identify a connective tissue fold that attaches the intestines to the posterior abdominal wall?", "Does the image show a feature that provides both vascular and nerve supply to the intestines?", "Is there evidence of arteries, veins, or capillaries delivering blood to and from the intestines?", "Can you see a structure that contains lymphatic vessels responsible for draining lymph from the gut?", "Is there a region that appears to house lymphoid tissue or facilitate immune cell movement within the abdomen?", "Does the image include a fold of tissue that anchors abdominal organs and provides structural support?", "Can you identify an area that stores fat and may serve as an energy reserve or provide insulation?", "Is there a visible pathway for autonomic nerves that could regulate intestinal motility and secretions?", "Does the image show a feature that allows the intestines to move while preventing them from becoming entangled?", "Can you see a structure that might transport absorbed nutrients from the intestines to the portal circulation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a muscular layer that could correspond to the tunica media of a blood vessel?", "Does the image show a tissue layer that could be part of the muscularis or tunica media?", "Can you see muscle bundles surrounded by connective tissue such as endomysium, perimysium, or collagenous stroma?"], "contexual_behavior": [], "functions": ["Does the image contain a structure that controls the flow of substances through hollow organs by altering the diameter of the lumen?", "Does the image show tissue maintaining vascular tone or contributing to blood pressure regulation?", "Does the image show a structure responsible for generating force for involuntary movements in organs?"]}}, "sites of lipid breakdown": {"yes_questions": {"contexual_properties": ["Does the image show any anatomical region where the breakdown of fats is likely to occur?", "Can you identify a structure associated with the digestion or processing of lipids?", "Is there a visible area that could participate in the chemical breakdown of dietary fats?", "Does the image contain any part of the digestive system where lipid catabolism might take place?"], "properties": ["Does the image show a region that could be part of the small intestine or stomach?", "Is there a structure present where enzymes such as pancreatic lipase or gastric lipase might be active?", "Can you identify an area where the pH is likely to be between 6 and 8 or between 3 and 6?", "Is there a region in the image that would be maintained at approximately 37\u00b0C?", "Does the image contain a location where the concentration of lipids could range from 1 to 10 g/dL after a meal?", "Can you see a structure where bile salts might be present at concentrations of 2\u201310 mM?", "Is there an area where free fatty acids could reach concentrations of 0.5\u20132 mM during digestion?", "Does the image show a region where monoglycerides might be found at 0.2\u20131 mM?", "Can you identify a location with high water content, such as 85\u201390% in chyme?", "Is there a structure composed of cells like enterocytes, goblet cells, or enteroendocrine cells?", "Does the image show a surface with extensive area, possibly due to villi and microvilli, reaching up to 200\u2013300 square meters?", "Can you identify a region where the partial pressure of oxygen is relatively low, around 30\u201340 mmHg?", "Is there a location where sodium concentration is about 140\u2013145 mM?", "Does the image contain a region where potassium concentration could be 5\u201315 mM?", "Can you see an area where calcium concentration might be 1\u20132 mM?"], "relational": ["Does the image show a region that is part of the digestive or lymphatic system where lipid processing might occur?", "Can you identify an organ such as the stomach, small intestine, or pancreas that could be involved in lipid breakdown?", "Is there visible tissue that could correspond to intestinal mucosa, pancreatic tissue, or gastric mucosa?", "Does the image contain anatomical regions like the duodenum, jejunum, or gastric antrum?", "Can you see cellular structures such as enterocytes, pancreatic acinar cells, or gastric chief cells?", "Is there evidence of ducts or vessels like the pancreatic duct, common bile duct, or lymphatic capillaries connected to regions of digestion?", "Does the image include organs such as the liver, gallbladder, or pancreas that interact with digestive processes?", "Can you identify a structure that is functionally or spatially integrated within the gastrointestinal tract?", "Is there a visible pathway or structure that could deliver lipids, such as chyme, bile ducts, or chylomicrons, to a digestive compartment?", "Does the image show compartments of the digestive system, such as the stomach, duodenum, or jejunum, that might participate in lipid breakdown?"], "contexual_behavior": ["Does the image show a structure whose activity increases during fasting, possibly due to hormone-sensitive lipase activation?", "Can you identify a region that would reduce its function in the presence of metabolic disorders such as type 2 diabetes?", "Is there a structure that accelerates lipid hydrolysis during exercise as a result of increased catecholamine levels?", "Does the image contain an area that might show impaired function in obesity due to chronic inflammation?", "Can you see a structure that would increase its activity in response to a high-fat diet through upregulation of lipolytic enzymes?", "Is there a region where lipid processing would decrease during insulin resistance because of impaired suppression of lipolysis?", "Does the image include a structure that enhances triglyceride breakdown during stress, possibly influenced by elevated cortisol?", "Can you identify an area that fails to mobilize fatty acids in cases of hormonal imbalance such as hypothyroidism?", "Is there a structure whose activity would be reduced in hypothermia due to decreased enzymatic activity?", "Does the image show a region that increases lipolysis during prolonged starvation to provide energy for vital organs?", "Can you see a structure that might have altered function in the context of liver disease due to disrupted lipid metabolism?", "Is there an area where efficiency decreases with aging as a result of changes in adipose tissue function?", "Does the image contain a region that increases fatty acid release during acute illness because of inflammatory cytokines?", "Can you identify a structure that reduces its role in lipid metabolism after feeding due to increased insulin levels?", "Is there an area that becomes hyperactive in certain endocrine disorders such as Cushing's syndrome due to excessive hormone stimulation?"], "functions": ["Does the image show a location where triglycerides are hydrolyzed into absorbable molecules?", "Is there a structure present that facilitates fat digestion through enzyme activity or emulsification?", "Can you identify an area where lipase activity or bile action might be occurring?", "Does the image include a region involved in the release of fatty acids for energy production?", "Is there evidence of a process that generates ATP from fatty acid oxidation?", "Can you see a site where dietary fats are converted into micelles for absorption?", "Is there a structure that could facilitate the uptake of fatty acids across enterocyte membranes?", "Does the image contain a region that regulates the rate or extent of lipid catabolism?", "Is there a visible feature associated with the enzymatic cleavage of dietary fats into monoglycerides and free fatty acids?", "Can you identify an area involved in the mobilization of stored lipids, such as the activation of lipases in adipose tissue?", "Does the image show a location where ketone bodies might be generated from fatty acids?", "Is there a structure that could be involved in the production of acetyl-CoA for ketogenesis?", "Can you see a region that participates in the release and transport of cholesterol from dietary or stored lipids?", "Is there evidence of a process supporting steroid hormone production through the provision of lipid-derived precursors?"]}, "no_questions": {"contexual_properties": ["Is there a firm, nodular mass visible that could be palpable due to fibrosis and calcification?", "Can you see areas with hemorrhagic changes, such as localized bleeding, possibly due to vascular injury during necrosis?", "Can you identify chalky deposits that may result from saponification and calcium soap formation?"], "properties": ["Can you identify a region with lower water content compared to normal adipose tissue?", "Is there an area that appears to have a normal temperature, unless there are signs of localized warmth from inflammation?", "Is there an area where inflammatory cells make up a significant portion of the tissue?"], "relational": ["Are there visual signs of scar formation or connective tissue proliferation in areas where fat is normally present?", "Does the image display areas of tissue surrounded by fibrous tissue or infiltrated by inflammatory cells?", "Does the image show changes in tissues that could impact the integumentary, digestive, or endocrine systems?"], "contexual_behavior": ["Is there evidence of disrupted hormone signaling in adipose tissue, such as altered adipokine activity or inflammation?", "Can you see evidence that the protective cushioning role of fat pads is compromised due to loss of shock-absorbing properties?", "Are there signs of disrupted fat absorption in the vicinity of pancreatic injury, such as digested peripancreatic fat?"], "functions": ["Can you see signs of fibrosis or increased collagen deposition indicating tissue remodeling?", "Does the image show evidence of a process involving enzymatic breakdown of lipids and inflammation?", "Is there visual evidence of free fatty acid release or the formation of fatty acid-calcium complexes, such as saponification?"]}}}
[ { "answer": "yes", "extracted_concepts": [ "lower-extremity deep venous thrombus", "embolus", "pulmonary artery branch" ], "question": "is embolus derived from a lower-extremity deep venous thrombus lodged in a pulmonary artery branch?" }, { "answer": "no", "extracted_concepts": [ "pulmonary artery branch", "edema" ], "question": "is edema lodged in a pulmonary artery branch?" }, { "answer": "embolus", "extracted_concepts": [ "pulmonary artery branch", "embolus" ], "question": "what is lodged in a pulmonary artery branch?" } ]	["lower-extremity deep venous thrombus", "embolus", "edema", "pulmonary artery branch"]	{"lower-extremity deep venous thrombus": {"yes_questions": {"contexual_properties": ["Does the image show evidence of a structure within a deep vein that appears enlarged, suggesting ongoing coagulation or propagation?", "Can you identify a feature that appears reduced in size, possibly indicating the effects of anticoagulation therapy or endogenous fibrinolysis?", "Is there a structure that appears more organized or fibrotic, consistent with fibroblast infiltration and collagen deposition over time?", "Does the image reveal a less organized or loosely structured area, which could correspond to early formation or active fibrinolysis?", "Can you observe a change in composition, such as a transition from a fibrin-rich to a collagen-rich appearance, indicating maturation or chronicity?", "Is there evidence of calcification within a venous structure, suggesting dystrophic changes in a chronic lesion?", "Does the image show a structure that appears more mobile or loosely attached to the vessel wall, raising concern for embolization risk?", "Can you see a region that is firmly adherent to the vessel wall, possibly due to organization and endothelialization?", "Is there an area within a deep vein that demonstrates increased echogenicity on ultrasound imaging, consistent with organization and fibrosis?", "Does the image display a hypoechoic region within a vein, which could indicate a newly formed, less organized clot?", "Can you observe a color change within a venous structure, such as a shift from red to pale or yellow, reflecting hemoglobin breakdown and fibrosis?", "Is there evidence of fragmentation or small pieces within a venous structure, possibly resulting from mechanical disruption, thrombolytic therapy, or spontaneous embolization?", "Does the image reveal new layers or stratification on the surface of an existing clot, suggesting recurrent thrombosis?", "Can you identify signs of recanalization, such as new vascular channels forming within a venous lesion during the healing process?", "Is there a difference in consistency, with some areas appearing softer or firmer, which could indicate the age of the lesion due to fibrosis?", "Does the structure within the deep vein appear to extend proximally or distally, suggesting propagation or thrombus extension?", "Can you see a decrease in density within a venous lesion, possibly due to lysis or partial resolution?", "Is there evidence of complete venous lumen obstruction, indicating that the structure has become more occlusive?", "Does the image show features such as organization, recanalization, or calcification that would indicate chronicity of a venous lesion?", "Can you observe surface irregularities or changes on a venous structure, possibly due to organization, recanalization, or partial lysis?"], "properties": ["Does the image show an elongated structure conforming to the lumen of a deep vein in the calf, femoral, or popliteal region?", "Is there an intraluminal object present in the deep veins of the lower limb that appears red or dark red in color?", "Can you identify a structure within a deep vein whose size ranges from a few millimeters to several centimeters in diameter?", "Is there an object in the deep veins that could have a length extending from a few centimeters to over 20 centimeters?", "Does the image contain a structure that appears soft and gelatinous, or possibly firmer if more organized, within a deep vein?", "Is there evidence of a mass in a deep vein that is likely composed primarily of fibrin and red blood cells?", "Can you see a structure in the deep veins that would have a density similar to blood, approximately 1.05\u20131.10 g/cm\u00b3?", "Is there a visible object in a deep vein that could have a high water content, around 70\u201380% by weight?", "Does the image show a structure in a deep vein that might have low elasticity, especially if it appears more organized?", "Is there a mass within a deep vein that could have a high protein content due to the presence of fibrin and plasma proteins?", "Can you identify an intravascular structure in the lower limb that may have low to moderate white blood cell content, particularly if it appears to be in an early stage?", "Is there a structure in a deep vein that might show signs of increased organization, suggesting it has been present for some time?", "Does the image reveal a mass in a deep vein that could have minimal cholesterol content?", "Is there an object in a deep vein that might show low calcium content, unless it appears chronic and possibly calcified?", "Can you see a structure in a deep vein that would have moderate platelet content, contributing to its stability?"], "relational": ["Does the image show evidence of an obstruction within the deep venous system of the lower limb?", "Can you identify a structure located in the thigh, calf, or popliteal fossa that appears abnormal?", "Is there a visible abnormality within the femoral, popliteal, iliac, or tibial veins?", "Does the image contain a finding that could affect the systemic venous circulation?", "Can you see any changes adjacent to skeletal muscle or subcutaneous tissue that might indicate a vascular issue?", "Is there a structure that could pose a risk to the pulmonary arteries or lungs if material were to migrate from it?", "Does the image show an abnormality within the boundaries of fascia, venous walls, or muscular compartments of the leg?", "Can you identify a finding in the lower limb that could impact the cardiovascular or pulmonary systems?", "Is there evidence of a process involving perforating veins, superficial veins, or the inferior vena cava in the lower extremity?", "Does the image reveal a potential obstruction in a vein that is surrounded by connective tissue or nerves?"], "contexual_behavior": ["Is there evidence of a structure within a major vein, such as the femoral or iliac, that appears large or causes significant blockage of blood flow?", "Can you identify a region where venous return might be severely impaired due to a sizable or occlusive formation?", "Does the image show a feature that could be loosely attached or appear fresh, potentially increasing the risk of embolization?", "Is there a visible extension of a structure into the proximal deep veins that might suggest increased embolic risk?", "Can you see signs of complete blockage within a vein, or an extensive area of clot burden that could obstruct blood flow?", "Are there visual indicators of local inflammation, such as endothelial activation or leukocyte accumulation, suggesting an acute process?", "Does the image suggest impaired oxygen delivery to tissues, possibly due to significant venous outflow obstruction or elevated venous pressure?", "Is there evidence of swelling or congestion in the lower limb that could be associated with prolonged immobility and venous stasis?", "Can you identify features that might indicate heightened procoagulant activity, possibly in the context of infection or inflammation?", "Are there signs of persistent inflammation or endothelial dysfunction that could be related to a chronic disease process?", "Does the image suggest that a clot is less stable or more prone to dissolution, potentially as a result of anticoagulant therapy?", "Is there evidence that a structure within a vein is more likely to fragment, possibly due to increased venous flow or mechanical stress from physical activity?", "Can you observe a reduction in clot size that might be attributable to thrombolytic treatment or fibrinolysis?", "Is there visual evidence of increased venous pressure in the leg, such as distended veins or swelling, that could result from major vein obstruction?", "Are there features suggesting that a clot has failed to resolve, possibly in the context of a clotting disorder or impaired fibrinolysis?", "Does the image indicate tissue hypoxia or exacerbated venous congestion, especially in the setting of heart failure?", "Is there evidence of impaired lymphatic drainage in the limb, such as chronic swelling, that could be secondary to venous hypertension?", "Can you identify signs of vein damage or incomplete clot resolution that might increase the risk of post-thrombotic syndrome?", "Are there visual clues that suggest altered clot behavior in response to hormonal changes, such as those occurring during pregnancy?", "Does the image show reduced signs of inflammation, possibly following anti-inflammatory treatment?", "Is there evidence of persistent venous obstruction or valve damage that could contribute to chronic venous insufficiency?", "Can you see features that might indicate an increased risk of recurrent thrombosis after surgery, such as signs of immobility or hypercoagulability?"], "functions": ["Does the image show evidence of venous obstruction or reduced blood flow in a deep vein of the lower limb?", "Can you identify any signs of increased venous pressure or stasis in the lower extremity?", "Is there a visible indication of impaired venous return, such as a blockage within a deep vein?", "Does the image suggest local inflammation, possibly due to endothelial activation or cytokine release?", "Can you see any features that might indicate a risk of thrombus fragments migrating toward the pulmonary circulation?", "Is there evidence of compromised tissue oxygenation, such as signs of local hypoxia or venous congestion?", "Does the image reveal swelling of the limb that could be attributed to increased hydrostatic pressure or fluid accumulation?", "Can you identify any features suggesting activation of the coagulation cascade, such as thrombin generation or platelet aggregation within a vessel?", "Is there any indication of venous valve dysfunction, such as valve incompetence or reflux in the deep veins?", "Does the image show signs of reduced limb mobility, pain, or swelling that might be related to a vascular abnormality?", "Are there chronic changes present, such as persistent edema or skin alterations, that could be associated with chronic venous insufficiency?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display any relationship between the coronary arteries and larger cardiovascular structures like the aorta, left ventricle, or right atrium?", "Are there features present that indicate the cardiovascular system is primarily affected?", "Are there signs of affected regions within the myocardium, such as the left ventricular wall or interventricular septum?"], "contexual_behavior": [], "functions": ["Is there evidence of myocardial infarction, such as localized tissue damage or scarring in the heart?", "Does the image reveal any signs of plaque rupture or thrombotic events within the coronary arteries?", "Are there visual cues suggesting transient ischemia or regions that could be associated with angina pectoris?"]}}, "embolus": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an object in the image whose size could range from a few micrometers to several centimeters?", "Can you identify a structure that appears irregular, spherical, elongated, or fragmented in shape?", "Does the image show a mass that could be composed of blood clot, fat, air, tumor cells, or foreign material?", "Is there a structure whose density might vary depending on whether it is blood-like or fat-like?", "Can you see an object that appears red, dark, pale, or yellowish in color?", "Is there a mass that looks soft and gelatinous, or alternatively firm and friable, suggesting different ages or stages of organization?", "Does the image contain an object whose mass could vary greatly depending on its size and composition?", "Can you identify a structure that might be made up of fibrin, platelets, fat droplets, air bubbles, tumor fragments, or amniotic fluid?", "Is there a mass that could have high water content if recent, or lower water content if composed of fat or calcified material?", "Does the image show an object that might have elevated cholesterol content, as seen in atheromatous or fat-based material?", "Can you see a structure that could contain significant protein, such as fibrin or plasma proteins?", "Is there a mass that might have high lipid content, as would be expected in fat-based or atheromatous material?", "Does the image contain a structure with increased calcium content, suggesting calcification or chronic organization?", "Can you identify an object whose consistency ranges from soft and pliable to firm and brittle?", "Is there a mass with a surface that appears smooth, rough, or irregular depending on its formation?"], "relational": ["Is there evidence of a foreign object or material moving within the circulatory system in the image?", "Does the image show an obstruction within a blood vessel such as an artery, vein, or capillary?", "Can you identify a blockage that could affect the lungs, brain, heart, or kidneys?", "Is there a structure in the image that could be causing impaired blood flow to cardiac, pulmonary, cerebral, or renal tissue?", "Does the image reveal a blockage in an arteriole or venule?", "Is there a visible object that appears to be transported by or lodged within a vein or artery?", "Can you see any evidence of a blockage in the pulmonary or cerebral circulation, or in the peripheral limbs?", "Does the image suggest that a structure originating from a heart chamber, deep vein, atherosclerotic plaque, or infected valve has traveled to another location?", "Is there a sign of a material that could have originated from the heart and is now causing a blockage elsewhere in the circulatory system?"], "contexual_behavior": [], "functions": ["Is there evidence in the image of an agent within a blood vessel that could obstruct circulation?", "Can you identify a structure that appears to be physically blocking the lumen of a vessel, potentially disrupting blood flow?", "Does the image show a feature that could cause vascular occlusion and reduce downstream perfusion?", "Is there a visible sign of tissue ischemia, such as pallor or discoloration, that might result from impaired blood supply?", "Can you see any indication of hypoperfusion or oxygen deprivation in tissues adjacent to a blocked vessel?", "Is there evidence of inflammation or endothelial activation near a vessel obstruction?", "Does the image suggest tissue necrosis or infarction in an area supplied by a blocked vessel?", "Can you observe any signs of organ dysfunction or ischemic injury that could be linked to impaired perfusion?", "Is there a disruption in nutrient delivery, waste removal, or cellular respiration in tissues downstream of a vascular blockage?", "Does the image show features suggestive of secondary clot formation or activation of the coagulation system near a vessel obstruction?"]}, "no_questions": {"contexual_properties": ["Does the neck appear thickened, possibly as a response to chronic lymphedema or fibrotic remodeling?", "Does the neck appear edematous, suggesting lymphatic obstruction or ongoing inflammatory processes?", "Is there visible pigmentation change on the neck that could be caused by chronic irritation, sun exposure, or dermatological conditions?"], "properties": ["Is the water content of the skin in the neck region consistent with normal physiological levels?", "Can you estimate if the distance from the mastoid process to the acromion exceeds 10 centimeters?", "Is there evidence of excess or overlapping skin folds along the side of the neck?"], "relational": ["Are the superficial or posterior cervical lymph nodes visible or displaced in the neck?", "Can you see any changes in the skin or subcutaneous connective tissue along the lateral neck?", "Is there evidence of pterygium colli present in the lateral or posterior neck?"], "contexual_behavior": ["Does the image show tissue redundancy in the neck that could impinge on the pharynx or esophagus, possibly contributing to swallowing difficulties under stress?", "Can you see thickened tissue in the neck that could compress superficial veins or arteries and potentially alter blood flow during exercise?", "Can you identify a neck structure where redundant skin or tissue could compress lymphatic vessels and potentially reduce lymphatic drainage in certain postures?"], "functions": ["Can you observe features that might indicate impaired lymphatic drainage, such as localized swelling suggestive of lymphedema?", "Is there any indication of mild compromise to airway patency, without evidence of significant obstruction?", "Does the image suggest possible interference with swallowing or speech due to tissue impingement on pharyngeal or laryngeal structures?"]}}, "edema": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region where tissue appears swollen due to increased fluid volume?", "Can you identify an area that might contain fluid with a clear or pale yellow appearance?", "Is there evidence of swelling in a dependent area, such as the lower limbs or sacral region?", "Does the image suggest the presence of tissue with increased water content, possibly exceeding 80% of its weight?", "Can you see a region where the fluid accumulation could range from several hundred milliliters to several liters?", "Is there an area that might contain fluid with a composition similar to plasma, including water, electrolytes, and protein?", "Does the image show swelling that could be due to fluid with a sodium concentration similar to plasma (approximately 135\u2013145 mmol/L)?", "Can you identify a region where the fluid might have a protein content consistent with either transudate (less than 3 g/dL) or exudate (greater than 3 g/dL)?", "Is there evidence of swelling where the fluid could have a specific gravity less than 1.015 or greater than 1.015, suggesting transudate or exudate?", "Does the image suggest the presence of fluid with a neutral to slightly alkaline pH, around 7.4?", "Can you see an area where the fluid's osmolarity might be similar to plasma, about 275\u2013295 mOsm/kg?", "Is there swelling in a region where the chloride concentration of the fluid could be close to plasma levels (around 98\u2013106 mmol/L)?", "Does the image show tissue that might contain fluid with a glucose concentration similar to plasma (approximately 70\u2013100 mg/dL)?", "Can you identify an area where the temperature of the accumulated fluid would likely reflect body temperature (36\u201337\u00b0C)?", "Is there a region where the clarity of the fluid could help distinguish between transudate (clear, non-turbid) and exudate (cloudy)?", "Does the image suggest a rate of fluid accumulation that could vary from several milliliters to liters per day depending on the underlying cause?"], "relational": ["Does the image show abnormal fluid accumulation in subcutaneous tissue or mucous membranes?", "Can you identify swelling in regions such as the lower limbs, ankles, or periorbital area?", "Is there evidence of fluid buildup in interstitial tissue or body compartments like the pleural or peritoneal cavity?", "Does the image display changes in organs such as the lungs, brain, liver, or kidneys that could indicate structural impact from excess fluid?", "Can you see signs of impaired lymphatic drainage, such as distended lymphatic vessels or lymph nodes?", "Is there visible swelling that could be related to lymphatic vessel dysfunction or obstruction?", "Does the image reveal features of the cardiovascular, renal, or lymphatic systems that might be involved in abnormal fluid retention?", "Are there indications of fluid accumulation in loose connective tissue or areolar tissue?", "Can you observe any alterations in capillaries, venules, or veins that might contribute to fluid leakage?", "Is there evidence of disruption to anatomical barriers like capillary endothelium or basement membrane that could affect fluid movement?"], "contexual_behavior": [], "functions": ["Does the image show evidence of tissue swelling that could indicate increased interstitial pressure?", "Can you identify an area where excess accumulation of interstitial fluid might be present?", "Is there a region where tissue fluid balance appears disrupted, possibly due to reduced fluid reabsorption?", "Does the image display localized swelling that could be associated with increased vascular permeability?", "Can you see signs of impaired organ function that might result from altered tissue architecture or increased pressure?", "Is there visual evidence suggesting that nutrient or oxygen delivery to tissues could be compromised, such as compressed capillaries or increased diffusion distance?", "Does the image show features that might indicate overloading or obstruction of lymphatic vessels, suggesting hindered lymphatic drainage?", "Can you identify areas where wound healing appears delayed, possibly due to increased infection risk or disrupted tissue repair?", "Is there a region where cellular signaling could be altered, such as changes in tissue structure that might affect cytokine gradients?", "Does the image reveal signs of chronic inflammation or tissue damage that could facilitate fibrosis?", "Can you see indications that metabolic waste removal from tissues might be impaired, such as slowed interstitial fluid flow or compromised venous and lymphatic clearance?"]}, "no_questions": {"contexual_properties": ["Is there a visible organ that is anatomically situated contralateral to another ovary in the image?", "Can you identify a structure that mirrors the position of an ovary on the other side of the body?", "Does the image show a paired structure located opposite to another similar organ?"], "properties": ["Is there an object whose estimated weight could be between 5 and 8 grams?", "Can you see an object that might contain between 5 and 10 antral follicles?", "Can you see a structure whose volume might range from 3 to 8 milliliters?"], "relational": ["Can you see an object situated near the fallopian tube, uterus, pelvic wall, or broad ligament?", "Can you identify a structure that is anatomically connected to the fallopian tube, potentially facilitating oocyte transport?", "Does the image contain a structure that is contralateral to another similar organ, indicating it is on the opposite side?"], "contexual_behavior": ["Can you identify an organ that is typically paired and may be located contralaterally to the main focus of the image?", "Does the image show a counterpart structure on the other side of the body relative to the main organ of interest?", "Is there evidence of a bilateral organ arrangement, with one member visible on the side opposite the primary structure?"], "functions": ["Does the image show a structure involved in oocyte production and hormone secretion?", "Does the image show an organ that interacts with the endocrine system to regulate reproductive processes?", "Can you see a structure nurturing primordial follicles through maturation stages?"]}}, "pulmonary artery branch": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a vessel that is part of the cardiovascular system and involved in pulmonary circulation?", "Can you identify a structure that originates from the pulmonary trunk or pulmonary artery?", "Is there a vessel supplying blood to lobar or bronchopulmonary segments of the lung?", "Does the image contain a structure directly connected to smaller arterial branches or capillary beds?", "Can you see a vessel that delivers blood to pulmonary alveoli or lung parenchyma?", "Is there a distal subdivision of the pulmonary trunk visible in the image?", "Does the image show vessels that branch into segmental pulmonary arteries or arterioles?", "Can you identify a structure adjacent to bronchi, pulmonary veins, or lung parenchyma?", "Is there a vessel present that is part of the pulmonary circulation within the circulatory system?", "Does the image include veins associated with regions supplied by a pulmonary arterial vessel, such as pulmonary veins?"], "contexual_behavior": ["Is there a vessel in the image that would show reduced blood flow in the presence of a pulmonary embolism?", "Can you identify a structure that would deliver more blood to the lungs during exercise due to increased cardiac output?", "Does the image show a vessel that might experience reduced oxygen delivery in pulmonary hypertension?", "Is there evidence of a vascular structure that could be obstructed by a thrombus or embolus, leading to inefficient blood transport?", "Can you see a vessel that would constrict in response to low oxygen levels through hypoxic vasoconstriction?", "Is there a structure that could dilate during chronic hypoxia or after prolonged exposure to low oxygen?", "Does the image contain a vessel that might show impaired blood flow in the context of chronic lung disease due to vascular remodeling?", "Is there a structure that would have increased pressure in cases of left heart failure because of backward transmission of elevated venous pressure?", "Can you identify a vessel that would show decreased perfusion after a vascular blockage such as a pulmonary embolism?", "Is there a vascular structure that could exhibit increased permeability and altered tone during acute respiratory distress syndrome?", "Does the image show a vessel that would reduce blood supply during severe dehydration due to hypovolemia?", "Is there a structure that would increase resistance in response to inflammation through endothelial dysfunction?", "Can you see a vessel that might fail to adapt during high altitude exposure if hypoxic vasoconstriction is excessive?", "Is there evidence of a vascular structure that could show abnormal flow patterns due to congenital heart disease or structural defects?", "Does the image contain a vessel that would increase its contribution to gas exchange during physical activity by recruiting additional capillaries?"], "functions": ["Does the image show a vessel responsible for transporting blood from the heart to the lungs for gas exchange?", "Can you identify a structure that distributes blood throughout the lung parenchyma to ensure efficient perfusion of the alveoli?", "Is there a vessel present that delivers blood to the pulmonary capillaries for oxygenation?", "Does the image contain a structure that carries deoxygenated blood from the right ventricle directly to lung tissue?", "Can you see a vessel that supplies blood to alveolar capillaries, enabling gas exchange?", "Is there a structure involved in transporting blood to the lungs for carbon dioxide removal?", "Does the image show a vessel that regulates blood flow within the lungs by adjusting vascular resistance?", "Can you identify a structure that contributes to maintaining pulmonary blood pressure by modulating vessel tone?", "Is there evidence of a vessel that branches extensively to ensure even distribution of blood to different lung regions?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an ovoid or lentiform collection within the muscle visible in the image?", "Does the image contain an area with a density between 50 and 80 Hounsfield units on CT?", "Can you identify a localized area within the temporal muscle or adjacent fascia that appears hyperdense or bright on CT?"], "relational": ["Is there involvement of fascia, such as the temporal fascia or deep temporal fascia, in the observed abnormality?", "Does the image reveal changes within skeletal muscle tissue, subcutaneous tissue, or periosteum in the temporal area?", "Is there evidence of risk or involvement of cranial nerves near the temporal region?"], "contexual_behavior": ["Can you see indications of metabolic dysfunction in the muscle, such as signs of ischemia or impaired nutrient delivery?", "Does the image reveal a hematoma or tissue damage that could increase the risk of secondary infection in the temporal region?", "Can you identify features that might indicate decreased neuromuscular coordination due to pain, inflammation, or structural disruption?"], "functions": ["Does the image reveal tissue changes that could activate nociceptors or cause local irritation?", "Does the image suggest weakness or dysfunction in a muscle involved in mastication, potentially leading to painful chewing?", "Is there evidence of mechanical obstruction or swelling that could interfere with the function of nearby tissues?"]}}}
[ { "answer": "by nests of closely packed glands", "extracted_concepts": [ "hyperplasia without atypia", "nests of closely packed glands" ], "question": "how is hyperplasia without atypia characterized?" }, { "answer": "yes", "extracted_concepts": [ "hyperplasia without atypia", "nests", "atypia", "glands" ], "question": "is hyperplasia without atypia characterized by nests of closely packed glands?" }, { "answer": "no", "extracted_concepts": [ "endoscopic view", "mallory-weiss", "longitudinally-oriented mallory-weiss", "nests of closely packed glands" ], "question": "is endoscopic view of a longitudinally-oriented mallory-weiss characterized by nests of closely packed glands?" }, { "answer": "hyperplasia without atypia", "extracted_concepts": [ "hyperplasia without atypia", "nests of closely packed glands" ], "question": "what is characterized by nests of closely packed glands?" }, { "answer": "nests of closely packed glands", "extracted_concepts": [ "hyperplasia without atypia", "nests of closely packed glands" ], "question": "what is hyperplasia without atypia characterized by?" } ]	["endoscopic view", "longitudinally-oriented mallory-weiss", "hyperplasia without atypia", "nests of closely packed glands", "nests", "mallory-weiss", "atypia", "glands"]	{"endoscopic view": {"yes_questions": {"contexual_properties": ["Is there evidence of mucosal swelling that could indicate inflammation or edema?", "Does the image show areas of discoloration suggestive of ischemia, hemorrhage, jaundice, or necrosis?", "Can you identify ulceration that might be associated with peptic ulcer disease or Crohn\u2019s disease?", "Is there visible bleeding that could point to gastrointestinal hemorrhage or erosive gastritis?", "Does the image reveal abnormal tissue growth such as neoplasms, polyps, or granulation tissue?", "Can you see narrowing of the lumen that may be due to strictures, tumors, or chronic inflammation?", "Is there increased mucus production that could be related to gastritis or irritable bowel syndrome?", "Does the image show loss of the normal vascular pattern, possibly due to chronic inflammation or dysplasia?", "Are erosions present that might be caused by NSAID injury or infectious colitis?", "Can you identify polyps that could be consistent with adenomatous or juvenile polyps?", "Is there evidence of thickened folds that may suggest edema or infiltrative disease?", "Does the image display pale mucosa, which could indicate anemia or chronic blood loss?", "Is friable tissue visible, possibly due to ulcerative colitis or severe inflammation?", "Can you see submucosal hemorrhage that might be related to trauma or vasculitis?", "Are strictures apparent that could be associated with Crohn\u2019s disease or post-surgical changes?", "Does the image show atrophic changes that may be seen in chronic gastritis or celiac disease?", "Is there evidence of exudates that could suggest infectious or pseudomembranous colitis?", "Can you identify edema that might be due to acute inflammation or venous congestion?", "Does the image reveal abnormal surface texture, possibly indicating dysplasia or metaplasia?", "Is there loss of normal architecture that could be due to advanced neoplasia or severe inflammation?"], "properties": ["Does the image display internal structures with predominant red, pink, white, or yellow coloration?", "Can you determine if the image resolution falls within the range of VGA to Full HD?", "Is the field of view angle in the image likely to span between 70 and 140 degrees?", "Does the brightness level in the image appear optimized for clear visualization of internal features?", "Can you assess whether the contrast ratio in the image is within the typical range of 300:1 to 1000:1?", "Is there evidence of magnification in the image that could range from 1x to 20x?", "Does the depth of field in the image seem to be between 3 mm and 50 mm?", "Can you infer if the aspect ratio of the image is either 4:3 or 16:9?", "Is there an indication that the frame rate of the video (if present) is between 25 and 60 frames per second?", "Can you estimate whether the pixel density in the image is between 100 and 300 pixels per inch?", "Does the image appear to have high sharpness, allowing for detailed visualization of mucosal surfaces?", "Is there evidence that the color balance setting is either auto white balance or manually adjusted?", "Can you tell if the illumination intensity in the image is within the range of 100,000 to 300,000 lux?", "Does the image exhibit low to moderate noise levels, suggesting good sensor quality and lighting?", "Is there any indication that the image format is JPEG, TIFF, DICOM, or MPEG?"], "relational": ["Does the image provide a perspective that allows observation of internal surfaces such as mucosa or submucosa?", "Can you identify blood vessels or lesions within the visualized area?", "Is there evidence that the image was captured from inside a region like the gastrointestinal, respiratory, or urinary tract?", "Does the view include anatomical features consistent with organs such as the esophagus, stomach, colon, bronchi, or bladder?", "Can you see tissues such as epithelial, connective, or lymphoid tissue in the image?", "Is the visualized area part of a system like the digestive, respiratory, urinary, or reproductive system?", "Are there identifiable landmarks such as the pylorus, vocal cords, ileocecal valve, or ureteral orifice present?", "Does the image show a cavity or lumen, such as a gastric lumen, colonic lumen, bronchial lumen, or bladder cavity?", "Is the perspective consistent with direct internal visualization for diagnostic or therapeutic purposes?", "Does the image suggest that it was obtained using a minimally invasive technique for internal examination?", "Are the boundaries of the visualized area defined by the mucosal surface, lumen boundary, or organ wall?"], "contexual_behavior": [], "functions": ["Does the image provide a direct visual perspective of internal anatomical structures for diagnostic purposes?", "Can you identify any abnormalities such as lesions, tumors, or signs of inflammation in the internal tissues shown?", "Is there evidence of magnified and illuminated visualization that could aid in detecting pathological changes?", "Does the image appear to guide or facilitate minimally invasive procedures by showing precise navigation of instruments within the body?", "Can you observe features that would allow for real-time monitoring of disease progression or assessment of pathological changes over time?", "Is there visual information that could support immediate clinical assessment or decision-making regarding internal organs?", "Does the image enable accurate localization of suspicious tissue suitable for targeted sampling or biopsy?", "Can you see visual cues that might help evaluate the effectiveness of a previous treatment or intervention?", "Is there a clear view of mucosal surfaces that could be assessed for abnormalities such as ulcers, erosions, or neoplastic changes?", "Does the image facilitate identification of a bleeding source, such as active hemorrhage or vascular lesions within a lumen?", "Is there evidence of therapeutic intervention, such as the removal of a polyp, with visual control over the treatment site?"]}, "no_questions": {"contexual_properties": ["Does the image suggest increased mechanical pressure on neural tissues, such as the medulla or spinal cord, at the craniovertebral junction?", "Is there evidence of a bony opening at the base of the skull with a reduced diameter compared to normal anatomy?", "Does the image show a narrowing of the passageway through which the spinal cord exits the skull?"], "properties": ["Is there a visible alteration in the angle between two cervical vertebrae, measuring around 35 degrees?", "Can you identify a structure where the narrowing exceeds 50% of its normal diameter?", "Is there evidence of an irregular and constricted bony ring at the base of the skull?"], "relational": ["Is there evidence of abnormal alignment between the first cervical vertebra and the occipital bone?", "Does the image show a narrowing at the large opening at the base of the skull where the uppermost cervical vertebra articulates?", "Is there an abnormal proximity between the cerebellar tonsils or brainstem and the foramen at the skull base?"], "contexual_behavior": ["Does the image suggest any abnormal positioning of the atlas vertebra affecting the passage for neural structures?", "Does the image show any narrowing at the large opening at the base of the skull?", "Can you see any compression or reduced space where the spinal cord passes through the base of the skull?"], "functions": ["Can you detect evidence of compensatory mechanisms such as increased collateral circulation or changes in cerebrospinal fluid absorption near the craniovertebral junction?", "Can you identify features that could indicate nerve root compression affecting cranial nerve integrity?", "Does the alignment of the upper cervical vertebrae appear altered in a way that could narrow the opening at the base of the skull?"]}}, "longitudinally-oriented mallory-weiss": {"yes_questions": {"contexual_properties": ["Is there a lesion that appears longer, possibly due to repeated episodes of forceful vomiting or retching?", "Can you identify a tear that seems deeper, which might indicate ongoing trauma or delayed healing?", "Does the image show a mucosal defect that appears widened, potentially from persistent mechanical stress or increased intragastric pressure?", "Is there evidence of increased bleeding at a mucosal site, possibly associated with mucosal disruption or coagulopathy?", "Can you see a tear with irregular edges, which could suggest impaired healing or secondary infection?", "Does any lesion display color changes that might be due to bleeding, necrosis, or healing processes?", "Is there a mucosal defect that appears edematous, indicating acute inflammation or tissue injury?", "Can you observe signs of healing, such as reduced inflammation or beginning epithelial regeneration, at the site of a mucosal tear?", "Is there evidence of inflammation at a mucosal injury, possibly due to exposure to gastric contents?", "Do you see necrotic tissue within a mucosal tear, which could be a result of compromised blood supply or infection?", "Is there granulation tissue visible at the site of a mucosal defect, indicating the proliferative phase of healing?", "Does any lesion appear to be covered by exudate, suggesting acute inflammation or secondary infection?", "Can you identify a mucosal tear that has reduced in size, possibly due to ongoing healing and tissue regeneration?", "Is there a lesion that appears more superficial, which could indicate healing of deeper layers and epithelialization?", "Do you observe tissue discoloration at a mucosal defect, potentially resulting from hemorrhage, necrosis, or inflammation?"], "properties": ["Is there a linear lesion following the long axis of the gastroesophageal junction or esophagus visible in the image?", "Can you identify a red or erythematous area with sharply demarcated, slightly raised edges at the mucosal layer near the gastric side of the gastroesophageal junction?", "Does the image show a mucosal disruption measuring between 0.5 and 4 centimeters in length and 2 to 10 millimeters in width?", "Is there a structure with irregular, friable texture and partial mucosal disruption without evidence of full-thickness perforation?", "Can you see an area where the squamous or columnar epithelium appears disrupted, possibly exposing the lamina propria?", "Is there a mucosal laceration with signs of hemorrhage or inflammatory infiltrate present?", "Does the image show a lesion limited to the mucosa, without extension into the submucosa?", "Can you identify a region where epithelial regeneration might be occurring as part of the healing process?", "Is there evidence of active bleeding or a recently healed area at the mucosal surface near the gastroesophageal junction?"], "relational": ["Is there a linear, longitudinally oriented disruption at the region where the esophagus meets the stomach?", "Does the image show a tear confined to the mucosal and submucosal layers at the gastroesophageal junction?", "Can you identify a lesion located in the distal esophagus or proximal stomach?", "Is there evidence of tissue disruption without full-thickness perforation near the lower esophageal sphincter or gastric cardia?", "Does the image display a structure adjacent to both the esophagus and the stomach with a linear orientation?", "Can you see a lesion that might be associated with blood vessels such as branches of the left gastric artery or esophageal veins?", "Is there a visible abnormality at or just below the gastroesophageal junction, specifically involving the mucosa?", "Does the image reveal a tear that is part of the gastrointestinal system and closely related to the circulatory system?", "Can you identify a linear lesion that is limited to the mucosal and submucosal layers at the junction of the distal esophagus and proximal stomach?"], "contexual_behavior": ["Is there evidence of a mucosal disruption in the esophagus that could compromise its barrier function?", "Can you identify a lesion that appears to involve submucosal vessels, suggesting a risk of hemorrhage?", "Does the image show a mucosal break near the gastroesophageal junction that might weaken the anti-reflux barrier?", "Is there a tear whose healing might be impaired in the context of chronic alcohol use?", "Can you see signs of acute pain or local inflammation that could disrupt normal esophageal motility and cause difficulty swallowing?", "Is there a lesion that appears to have resulted from vomiting or retching, leading to further mucosal injury and loss of protective barriers?", "Does the image reveal exposed submucosa that could increase susceptibility to infection?", "Is there visual evidence of inflammation or pain that might interfere with coordinated muscle contractions in the esophagus during stress?", "Can you identify a lesion where ongoing mechanical trauma or possible coagulopathy could disrupt normal clot formation and stable hemostasis?", "Does the image suggest a tear that could lead to excessive blood loss in the presence of impaired clotting mechanisms?", "Is there a lesion whose healing might be compromised in a malnourished patient due to deficient tissue repair?", "Can you see an area in the lower esophagus where the mucosal barrier is compromised, potentially allowing increased acid exposure?", "Is there evidence of impaired esophageal defense mechanisms during retching, such as disrupted mucosal integrity and increased vulnerability to injury?", "Does the image show signs of prolonged bleeding that could be exacerbated by liver disease or portal hypertension?", "Is there a mucosal lesion that appears less able to withstand mechanical stress, indicating altered response to increased intra-abdominal pressure?"], "functions": ["Does the image show a disruption of the mucosal barrier at the gastroesophageal junction that could increase the risk of bleeding?", "Is there evidence of a lesion at the gastroesophageal junction that might impair barrier function?", "Can you identify a break in the esophageal mucosa with exposure of submucosal vessels, suggesting a risk of hemorrhage?", "Does the image reveal a site where the continuity of the esophageal mucosa is interrupted, potentially leading to bleeding?", "Is there a visible area where mucosal protection and hemostasis appear compromised, possibly affecting epithelial integrity or blood vessel stability?", "Can you see exposed submucosal blood vessels that could be a source of upper gastrointestinal bleeding?", "Does the image show features consistent with acute upper gastrointestinal symptoms, such as a mucosal injury that could cause hematemesis or epigastric pain?", "Is there a lesion that might cause pain or discomfort during swallowing, potentially resulting in odynophagia or dysphagia?", "Can you identify a persistent site of mucosal injury and inflammation that could delay healing and regeneration?", "Does the image suggest increased susceptibility to local infection or esophagitis due to compromised mucosal defense?", "Is there evidence of mucosal irritation that might trigger protective reflexes such as vomiting or coughing?", "Can you see a disruption that could transiently impede the smooth passage of food or liquids, possibly causing obstruction symptoms?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a visible change in the circumflex or left anterior descending artery?", "Does the image show evidence of a condition affecting the cardiovascular system?", "Can you identify any abnormalities in the marginal or diagonal branches of the coronary arteries?"], "contexual_behavior": [], "functions": ["Are there visual cues indicating smooth muscle proliferation or increased extracellular matrix within the vessel wall?", "Does the image show evidence of narrowed arteries that could restrict blood flow to the heart muscle?", "Can you see features that might suggest impaired vasodilation or dysfunction of the endothelium in the coronary arteries?"]}}, "hyperplasia without atypia": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a tissue area where epithelial cells are proliferative but have uniform nuclei and are surrounded by abundant stroma?", "Can you identify a region where the tissue thickness appears moderately increased, approximately 1 to 2 millimeters?", "Is there an area with elevated cell density that does not reach the levels seen in atypical proliferative lesions?", "Do the nuclei in the epithelial cells appear small and regular, similar to those in normal endometrial tissue?", "Is there evidence of a mildly increased mitotic index, but not to the extent observed in malignant lesions?", "Can you see crowded glands that maintain non-complex architectural outlines?", "Are the epithelial cells characterized by moderate, eosinophilic cytoplasm without significant vacuolization?", "Does the gland-to-stroma ratio appear increased, while intervening stroma is still preserved and glands do not fuse or appear back-to-back?", "Is there a visible increase in epithelial proliferation without signs of cytological atypia?", "Do the nuclei display a fine, evenly distributed chromatin pattern without hyperchromasia?", "Can you observe two to three layers of epithelial cells, indicating mild stratification?", "Are the glands predominantly round to oval and only mildly irregular, without complex or cribriform patterns?", "Is secretory material generally absent or minimal in the tissue region under consideration?", "Does the affected tissue appear pink to light purple with hematoxylin and eosin staining?", "Is the cytoplasmic-to-nuclear ratio preserved and similar to that of normal endometrial cells?"], "relational": ["Does the image show a region within the endometrium, prostate, or breast that appears to have increased numbers of cells?", "Can you identify an area where epithelial or glandular cells are more numerous but maintain normal nuclear appearance?", "Is there a structure within the uterus, prostate gland, or mammary gland that shows preserved cellular architecture despite cell proliferation?", "Does the image contain glands or ducts, such as endometrial glands, prostatic acini, or mammary ducts, that appear enlarged without signs of nuclear atypia?", "Can you see a region in the endometrial lining, prostatic glands, or breast lobules with mild proliferation of the surrounding stroma?", "Is there evidence of increased glandular or epithelial layers adjacent to the basement membrane or connective tissue, but without abnormal nuclear features?", "Does the image show a histological section where the epithelial layer, glandular layer, or subepithelial stroma appears thickened but orderly?", "Can you identify an area within the reproductive, male genitourinary, or mammary system that demonstrates increased cell proliferation with absence of nuclear atypia?", "Is there a region where the stroma adjacent to proliferating glands or ducts shows edema or reactive changes?", "Does the image display preserved glandular or ductal architecture in a site commonly affected by hyperplastic processes, such as the endometrial lining or breast lobules?"], "contexual_behavior": ["Does the image show evidence of increased endometrial proliferation that could be associated with elevated estrogen levels?", "Is there a region where endometrial tissue appears expanded, possibly due to prolonged estrogen exposure without opposing progestin?", "Can you identify areas where the normal architecture of the endometrium seems disrupted, potentially as a result of chronic inflammation?", "Is there visual evidence of increased cellular turnover or regenerative activity following endometrial injury or repair?", "Does the image suggest reduced endometrial proliferation that might be consistent with postmenopausal status?", "Are there features indicating impaired growth regulation in the context of metabolic syndrome, such as persistent endometrial thickening?", "Can you observe endometrial tissue that appears not to regress despite the absence of an obvious proliferative stimulus, possibly due to persistent risk factors like obesity or chronic inflammation?", "Is there a visible decrease in endometrial proliferation that could be attributed to progestin therapy?", "Are there abnormal glandular or stromal responses in the endometrium that might reflect functional alterations during chronic inflammation?", "Does the image suggest increased persistence of endometrial proliferation that could be associated with an immunocompromised state?", "Is there evidence of decreased regression of endometrial tissue in the context of obesity-related hormonal imbalance?", "Can you see signs of regenerative proliferation in the endometrium following tissue injury?", "Are there areas where endometrial tissue fails to regress in the absence of atypical cellular features, possibly due to a persistent proliferative stimulus?", "Does the image reveal changes in endometrial growth dynamics that might be linked to perimenopausal hormonal fluctuations?"], "functions": ["Does the image show a tissue with an increased number of cells while maintaining normal cellular appearance and organization?", "Can you identify an area where tissue expansion is present without evidence of abnormal cell features?", "Is there a region where the architecture of the tissue appears preserved despite an apparent increase in cell density?", "Does the image reveal signs of enhanced tissue function or increased physiological capacity without disruption of normal structure?", "Can you see evidence of regeneration or repair characterized by additional cells that look morphologically normal?", "Is there a part of the tissue that appears enlarged or more massive, yet retains its normal function and structure?", "Does the image suggest elevated rates of cell division with cells that remain organized and structurally typical?", "Can you identify tissue that may be responding to hormonal or endocrine signals, resulting in increased cell numbers without signs of malignancy?", "Is there visual evidence of an adaptive response where tissue capacity is increased, but the overall integrity and organization are maintained?", "Does the tissue in the image appear to have undergone growth regulated by factors such as hormones or growth signals, with feedback mechanisms preventing excessive proliferation?", "Can you observe a shift toward cell growth over cell death, while overall tissue homeostasis and normal appearance are preserved?"]}, "no_questions": {"contexual_properties": ["Is there any distortion of these lines, which might indicate burns, contractures, or severe skin disease?", "Are there any areas where the lines appear narrowed, possibly as a result of skin tightening, scarring, or fibrosis?", "Can you observe any widening of these lines that might be associated with chronic swelling, connective tissue disorders, or past trauma?"], "properties": ["Can you observe that the distance between the primary lines on the palm is about 1 to 2 centimeters apart?", "Are the grooves on the palm shallow, with a depth of about 0.5 to 1 millimeter?", "Are the main lines on the palm following a curved or arched path along the natural contours of the hand?"], "relational": ["Is there evidence of surface markings formed by the epidermis and dermis layers of the skin on the palm?", "Can you identify lines or creases that are associated with the metacarpophalangeal or interphalangeal joints?", "Can you see any features on the palm that are situated near the course of the median or ulnar nerves?"], "contexual_behavior": ["Does the image show palm skin lines that are less prominent, which could be associated with connective tissue disorders affecting collagen?", "Is there a loss of typical skin fold function as flexion guides, potentially due to reduced elasticity from conditions like scleroderma?", "Do the palm skin lines appear more visible, as might be seen after prolonged immersion in water?"], "functions": ["Can you identify natural hinge lines in the skin that facilitate folding and extension of the palm?", "Can you identify structures that allow the skin to fold smoothly during hand movement?", "Does the image show features that enhance the flexibility and range of motion of the palm?"]}}, "nests of closely packed glands": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure measuring between 0.1 and 2 millimeters in diameter?", "Can you identify a rounded or ovoid cluster of glands?", "Is there a group containing approximately 5 to 50 glands in close proximity?", "Does the image reveal clusters composed of epithelial cells such as acinar or ductal types?", "Can you see tightly cohesive clusters of cells with minimal intervening stroma?", "Are there glands within the cluster that measure about 30 to 100 micrometers in diameter?", "Does the image display a region of high gland density with little connective tissue between them?", "Is there an area that appears pale pink to eosinophilic under microscopic examination?", "Can you observe cells with moderate to abundant eosinophilic or clear cytoplasm?", "Does the nuclear-to-cytoplasmic ratio in these cells appear low to moderate?", "Are mitotic figures rare or is the mitotic rate low within the observed cluster?", "Do the glands in the cluster have small lumens, often less than 20 micrometers in diameter?", "Is the extracellular matrix in the region sparse and mainly composed of collagen and glycoproteins?", "With hematoxylin and eosin staining, do you see basophilic nuclei and eosinophilic cytoplasm in the cluster?", "Is there evidence of mucin or serous fluid as the secretory product within the glands of the cluster?"], "relational": ["Does the image show a structure that is part of either the endocrine or exocrine system?", "Can you identify an area that could belong to the prostate, salivary glands, or pancreas?", "Is there a region surrounded by fibrous stroma or connective tissue?", "Does the image contain clusters of acinar, tubular, or alveolar glands?", "Can you see anatomical features adjacent to ducts, blood vessels, or nerves?", "Is there evidence of excretory or secretory ducts within the tissue?", "Does the image include a region that could be located in the pelvis, oral cavity, or abdomen?", "Are there visible clusters of epithelial, myoepithelial, or secretory cells?", "Can you identify a structure embedded within or supported by stroma or extracellular matrix?", "Is there a component that appears to be part of a lobule or a larger glandular organ?"], "contexual_behavior": ["Does the image show a cluster of structures that might increase secretory activity during periods of hormonal signaling or heightened functional demand?", "Can you identify a group of glands that could reduce hormone production in the presence of chronic inflammation or signs of atrophy?", "Is there evidence of glandular clusters that might fail to release normal secretions due to obstruction, necrosis, or severe cellular damage?", "Does the image display glandular nests with signs of immune cell infiltration or inflammation that could impair their function?", "Can you see a collection of glands that might increase enzyme secretion in response to trophic hormone stimulation or neural activation?", "Is there a cluster of glands that appears to have decreased metabolic activity, possibly due to hypoxia or oxidative damage?", "Does the image show glandular structures that could be altering their secretory profile in response to infection, such as producing antimicrobial peptides or inflammatory mediators?", "Can you identify nests of glands that appear hyperactive, suggesting conditions like hyperplasia or neoplastic transformation?", "Is there evidence of glandular clusters with disrupted structural integrity or impaired signaling pathways, potentially leading to local tissue dysregulation?", "Does the image contain glandular nests that might show reduced function due to hormonal imbalance or decreased levels of stimulating hormones?", "Can you see a group of glands that appears to be increasing activity to support tissue regeneration and repair?", "Is there a cluster of glands that seems unable to maintain normal tissue homeostasis, possibly due to chronic injury or persistent disease?", "Does the image show glandular nests that might be altering their function in response to environmental toxins, such as by changing secretion patterns or showing signs of cellular adaptation?", "Can you identify clusters of glands that could be decreasing secretion due to nutrient deficiency or limited substrate availability?", "Is there evidence of glandular nests with increased output, possibly as a result of chronic stimulation or prolonged activating signals?"], "functions": ["Does the image show a cluster of structures that could be responsible for releasing secretory products into nearby tissues or ducts?", "Can you identify areas where glandular cells appear densely grouped, potentially indicating enhanced secretory output?", "Is there evidence of structures that might regulate the composition of local fluids or support balanced cellular turnover?", "Does the image contain features suggesting modulation of the local microenvironment, such as regions influencing pH or ion balance?", "Can you see concentrated sites that could be involved in the biosynthesis and release of hormones or enzymes?", "Are there structures that appear to support the integrity of epithelial layers by providing continuous protective secretions?", "Does the image include regions that might be involved in modulating immune responses through secretion of antimicrobial peptides or cytokines?", "Can you identify areas that could contribute to tissue remodeling or repair by releasing growth factors or matrix-modifying enzymes?", "Is there visual evidence of structures producing fluid or mucus to lubricate and protect tissue surfaces?", "Do any regions in the image suggest adaptive changes in secretory activity or cellular proliferation in response to local stimuli?"]}, "no_questions": {"contexual_properties": ["Is there an area with increased mass effect, such as compression of adjacent structures, due to edema or hematoma expansion in the acute to subacute phase?", "Is there an area that appears more pronounced or hyperdense on imaging, possibly due to recent blood accumulation?", "Is there evidence of surrounding edema, such as swelling or hypoattenuation, indicating an inflammatory response and blood-brain barrier disruption?"], "properties": ["Is there a lesion composed of infarcted parenchyma, hemorrhagic components, and inflammatory cells?", "Is there a lesion measuring between 1 and 5 centimeters in diameter visible in the image?", "Does the image show an area with variable signal intensity on T1-weighted MRI, possibly hyperintense if in the subacute stage?"], "relational": ["Is there an area where arteries, veins, or capillaries appear disrupted or abnormal?", "Does the image reveal evidence of vessel occlusion, hemorrhage, or ischemia in a localized area?", "Can you identify a lesion within the brain, lungs, or intestines?"], "contexual_behavior": ["Can you identify a well-demarcated zone where tissue appears infarcted and contains blood extravasation?", "Is there an area that appears abnormal due to both loss of blood supply and the presence of hemorrhage?", "Does the image show a focal lesion characterized by both necrosis and hemorrhagic features?"], "functions": ["Is there a region where the removal of cellular debris might be impaired due to disrupted circulation or damaged phagocytic cells?", "Can you observe features suggestive of inflammation, such as increased cellularity or tissue swelling, in a localized area?", "Can you identify a region where local metabolic activity might be suppressed due to cell death and impaired substrate supply?"]}}, "nests": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears larger than usual, possibly indicating recent construction or material accumulation?", "Can you identify an object that seems to have lost material, eroded, or become more compact over time?", "Is there evidence of a structure whose shape has changed due to remodeling, weather impact, or damage?", "Does the image contain an object that looks heavier, perhaps due to the addition of building materials, eggs, or debris?", "Can you see a structure that appears lighter, possibly as a result of material loss, drying, or decomposition?", "Is there a visible change in color that could be due to weathering, sunlight exposure, or the addition of new materials?", "Does the image show a structure that looks fragile, potentially from moisture damage, aging, or pest activity?", "Can you identify an object that appears more robust, possibly reinforced with additional or stronger materials?", "Is there evidence that the composition of a structure has changed, such as the incorporation of new materials or degradation of existing ones?", "Does the image show an accumulation of debris, suggesting neglect, environmental deposition, or lack of maintenance?", "Can you see signs of structural material loss, possibly from weather damage, predation, or removal by occupants?", "Is there a structure that appears more compact, perhaps due to compression by occupants or environmental pressure?", "Does the image show an object that looks more porous, possibly from material degradation, removal, or loose construction?", "Can you identify signs of mold or fungal growth, which might indicate high humidity, moisture retention, or poor ventilation?", "Is there evidence that a structure has become wetter after rainfall or flooding, or drier during periods of heat or low humidity?", "Does the image show signs of wear or damage, possibly from harsh weather, repeated use, or predator attacks?", "Can you see an accumulation of foreign materials, suggesting environmental contamination or that occupants have brought in external objects?", "Is there evidence that a structure has been insulated with additional materials, possibly as an adaptation to cold weather?", "Does the image show a change in texture that could result from material changes, weathering, or occupant modifications?", "Can you identify abnormal features that might be due to disease, parasite infestation, or construction defects?"], "properties": ["Is there a structure in the image that appears to be cup-shaped, dome-shaped, platform-like, or pendant?", "Can you identify an object composed of materials such as twigs, grass, leaves, feathers, mud, or animal hair?", "Does the image show a structure with a predominantly brown or gray coloration, reflecting natural tones?", "Is there an object whose size appears to range from 5 to 50 centimeters in diameter?", "Can you see a structure that might weigh between 50 and 500 grams, suitable for small to medium-sized birds?", "Does the image contain an object with a wall thickness that could be approximately 1 to 5 centimeters?", "Is there a structure whose diameter seems to fall between 10 and 30 centimeters?", "Can you identify an object that has a rough exterior and a softer interior lining?", "Does the image show a structure with a depth that could be between 3 and 10 centimeters, as seen in cup-shaped forms?", "Is there an object that likely has a low moisture content, possibly less than 15% by weight?", "Can you see a structure that might maintain a temperature between 25 and 40 degrees Celsius, depending on its environment?", "Does the image contain an object whose density could be estimated between 0.1 and 0.5 grams per cubic centimeter?", "Is there a structure whose material composition might have a pH between 6.0 and 7.0, indicating neutral to slightly acidic conditions?", "Can you identify an object with an outer framework of coarse materials and an inner lining of softer substances?", "Does the image show a structure whose volume could be between 200 and 1,000 cubic centimeters, suitable for small to medium-sized birds?"], "relational": ["Does the image show small, discrete clusters of cells within a tissue?", "Can you identify compact cellular aggregates embedded within the surrounding stroma or connective tissue?", "Is there evidence of cell groups that are separated from each other by extracellular matrix?", "Are there clusters of cells present within epithelial tissue, endocrine glands, or tumors?", "Can you see groups of neuroendocrine cells, melanocytes, or tumor cells organized together?", "Are there cellular aggregates that appear as subunits within lobules or tissue compartments?", "Does the image contain structures that are components of glands, tumors, or epithelia?", "Are there cell clusters found adjacent to blood vessels, connective tissue, or nerve fibers?", "Can you observe compact groups of cells with clear boundaries and high cellular density?", "Is there a structure present in the endocrine, integumentary, or nervous system that consists of tightly packed cells?", "Do you see cell groups interacting with basement membrane, capillaries, or immune cells at the microscopic level?"], "contexual_behavior": ["Is there a structure in the image that appears poorly concealed or exposed, potentially increasing the risk of predation?", "Can you identify an object whose insulation or construction might be insufficient for temperature regulation during extreme weather?", "Does the image show a structure that could be compromised by environmental contaminants, possibly affecting the development of young animals?", "Is there an object that might offer reduced shelter from heavy rainfall due to the use of permeable materials or lack of coverage?", "Can you see a structure that may lack stability or structural integrity under high wind conditions?", "Does the image contain an object that appears limited in size or resources, potentially supporting fewer offspring?", "Is there evidence of a structure that could be more susceptible to parasitism in a densely populated area?", "Can you identify an object that seems to have increased insulation or modifications for warmth, possibly in response to colder seasons?", "Does the image show a structure whose availability or quality might be affected by habitat disturbance, potentially impacting reproductive success?", "Is there a structure that could enhance the survival of young animals when food resources are abundant and parental care is evident?", "Can you see an object that appears less functional due to visible signs of disease or infestation?", "Is there evidence of a structure that has been reinforced or shows increased defensive features, possibly related to the breeding season?", "Does the image show a structure whose camouflage might be reduced due to changes in surrounding vegetation or habitat alteration?", "Can you identify an object whose design could buffer against rapid temperature fluctuations, facilitating thermoregulation?", "Is there a structure that appears less effective at retaining moisture, possibly due to dried-out materials during drought conditions?"], "functions": ["Is there a structure in the image that provides shelter and supports reproduction for certain organisms?", "Can you identify something that acts as a physical barrier to protect developing offspring from environmental hazards or predators?", "Does the image show a feature that could help regulate temperature for eggs or young by providing insulation?", "Is there evidence of a structure that reduces predation risk by concealing eggs or young and limiting predator access?", "Can you see an environment that offers a safe and suitable place for egg laying and development, supporting reproductive success?", "Is there a centralized location visible that would facilitate parental care behaviors such as feeding, brooding, or guarding offspring?", "Does the image contain a feature that might help maintain humidity and retain moisture for developing embryos?", "Can you identify something that contributes to offspring survival by providing protection and a stable microclimate?", "Is there a structure present that would support incubation by enabling consistent warmth and controlled environmental conditions for eggs?", "Does the image suggest the presence of a shared space that could be important for group breeding, cooperation, or communal living among organisms?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of malformed brainstem or primitive neural elements with no visible cerebral hemispheres?", "Does the image reveal disorganized or incomplete remnants of forebrain and midbrain structures?", "Is there evidence of microcephaly or a head circumference far below the expected range for gestational age?"], "relational": ["Are the skull bones missing or severely underdeveloped in the cranial area?", "Is there a failure of cranial bone or overlying ectoderm development visible in the image?", "Is there a lack of normal scalp covering the cranial region?"], "contexual_behavior": ["Does the image indicate impaired coordination of fetal movement due to missing or underdeveloped motor cortex and neural circuits?", "Is there evidence of disrupted signaling between the brain and other organs, as might occur if neural pathways for inter-organ communication are absent?", "Does the image suggest abnormal regulation of heart rate or respiration that could result from a malformed or absent brainstem?"], "functions": ["Does the image suggest inadequate regulation of involuntary functions like blood pressure or digestion, indicating autonomic instability?", "Is there evidence of profound sensory and motor deficits due to missing essential brain structures?", "Can you observe signs of impaired respiratory or cardiovascular regulation, such as respiratory failure or abnormal heart function?"]}}, "mallory-weiss": {"yes_questions": {"contexual_properties": ["Does the image show a lesion at the gastroesophageal junction that appears elongated, possibly indicating repeated episodes of forceful vomiting?", "Is there evidence of a tear that appears deeper, suggesting ongoing mechanical trauma or severe retching?", "Can you identify a mucosal disruption with signs of heavy bleeding, which might indicate involvement of submucosal vessels or impaired coagulation?", "Does the lesion display swelling or edema, consistent with local tissue injury and inflammation?", "Is there a change in color of the affected area, possibly due to healing, hemorrhage, or the presence of necrotic tissue?", "Can you observe surrounding inflammation near a mucosal tear, suggesting tissue damage and an inflammatory response?", "Is there a visible tear that is more apparent due to active bleeding, edema, or exposed submucosa?", "Does the lesion show features of healing, such as epithelial regeneration or the presence of granulation tissue?", "Can you see evidence of clot formation at the site of a mucosal tear, indicating that bleeding has slowed and coagulation is occurring?", "Is there an area of tissue necrosis at the site of the lesion, possibly due to compromised blood supply or infection?", "Does the tear appear wider than expected, which could be a result of continued mechanical stress or recurrent vomiting?", "Is there visible granulation tissue at the site of the lesion, suggesting the reparative phase of mucosal healing?", "Can you identify increased mucosal disruption, possibly due to recurrent trauma or impaired healing?", "Does the appearance of the lesion suggest recent intervention, such as cauterization or clipping, or signs of natural healing?", "Is there persistent oozing of blood from the tear, which may indicate failed hemostasis or an underlying coagulopathy?"], "properties": ["Is there a linear lesion at the junction between the esophagus and the stomach, particularly on the gastric side?", "Can you identify a sharply demarcated, linear mucosal laceration in the image?", "Does the image show a tear that is limited to the mucosa or possibly extends into the submucosa?", "Is there a lesion with a length between 0.5 and 4 centimeters and a width less than 5 millimeters?", "Can you see a structure with reddish or bright red coloration suggestive of fresh bleeding?", "Is there evidence of mild to moderate blood loss in the area of the gastroesophageal junction?", "Does the image display a single linear tear rather than multiple tears at the mucosal surface?", "Can you observe features consistent with submucosal hemorrhage adjacent to a linear mucosal laceration?", "Is there a lesion at the gastric cardia that appears likely to heal within a few days to two weeks?"], "relational": ["Does the image show any abnormality at the junction between the esophagus and the stomach?", "Is there evidence of disruption limited to the mucosal or submucosal layers in the upper gastrointestinal tract?", "Can you identify a lesion located at the distal end of the esophagus?", "Is there a visible abnormality that extends into the proximal region of the stomach?", "Does the image display any changes near the lower esophageal sphincter or the gastric cardia?", "Are there signs of injury adjacent to the Z-line or the cardia of the stomach?", "Can you see involvement of blood vessels such as branches of the left gastric artery or submucosal veins near the gastroesophageal junction?", "Is there a lesion that appears to be bordered by the muscularis propria and adventitia?", "Does the image contain any findings at the anatomical site where the esophagus meets the stomach?"], "contexual_behavior": ["Does the image show evidence of mucosal disruption at the gastroesophageal junction that could expose submucosal vessels?", "Is there a visible longitudinal tear near the junction between the esophagus and stomach that might be associated with recent forceful vomiting?", "Can you identify signs of acute hemorrhage or blood loss in the region where the esophagus meets the stomach?", "Does the image reveal epithelial damage or barrier disruption that would reduce the protective function of the esophageal mucosa?", "Is there evidence of local edema or inflammation in the esophageal lining that could cause pain during swallowing?", "Can you see features suggesting re-epithelialization or tissue repair in an area of previous mucosal injury?", "Does the image indicate a breach in the mucosal barrier that would make the underlying tissue more vulnerable to gastric acid exposure?", "Is there any indication of mucosal fragility or delayed healing that might be associated with ongoing alcohol use?", "Can you observe signs of fibrosis or chronic changes in the esophageal lining that would suggest reduced regenerative capacity after repeated injury?", "Does the image show blood accumulation or other features that could interfere with the normal passage of food through the esophagus?", "Is there visual evidence of weakened structural integrity in the esophageal mucosa that would compromise its defense against mechanical stress?"], "functions": ["Is there evidence of mucosal injury or bleeding at the junction between the esophagus and stomach?", "Does the image show signs of acute upper gastrointestinal bleeding that is not related to varices?", "Can you identify a source of hematemesis originating from a laceration in the mucosa?", "Is there visible disruption of the mucosal layer at the gastroesophageal junction with possible exposure of blood vessels?", "Does the image suggest activation of coagulation or local inflammation in response to bleeding at the gastroesophageal junction?", "Are there visual indications of increased peristalsis or other physiological responses to acute bleeding?", "Can you see features consistent with epithelial regeneration or scar formation in the esophageal mucosa?", "Is there evidence of an acute upper gastrointestinal hemorrhage that might require endoscopic intervention?", "Does the image show disruption of the normal barrier between the esophagus and stomach, suggesting increased susceptibility to further injury or infection?"]}, "no_questions": {"contexual_properties": ["Is there an opening in the skull that appears to have an irregular or asymmetric shape, possibly due to congenital malformation or bone remodeling?", "Can you identify irregular bone growth at the base of the skull that could indicate disorders such as osteopetrosis or Paget\u2019s disease?", "Is there evidence of structural deformity in a skull base opening that could result from genetic mutation, trauma, or chronic disease?"], "properties": ["Is there an indication of an elevated pressure gradient, possibly exceeding 5 mmHg, across a constricted opening at the base of the skull?", "Does the image suggest a reduction in the volume of a cranial opening by approximately 30% to 50%?", "Does the image show a structure at the cranial base that appears oval or irregular instead of round?"], "relational": ["Is there evidence of compression or impingement on nerves such as the spinal accessory nerve or upper cervical spinal nerves near the craniovertebral junction?", "Is there any indication of altered passage where the spinal cord connects to the brainstem?", "Can you identify any disruption in the anatomical connection between the skull and vertebral column at the large opening at the skull base?"], "contexual_behavior": [], "functions": ["Can you identify changes that might be associated with motor weakness, sensory loss, ataxia, or difficulty swallowing?", "Is there evidence of compromised blood flow to the brain or spinal cord, such as compression of vertebral arteries or venous pathways?", "Can you identify features suggesting compression of the lower brainstem or upper cervical spinal cord?"]}}, "atypia": {"yes_questions": {"contexual_properties": ["Does the image show evidence of increased nuclear size in cells that might be undergoing malignant transformation?", "Can you identify abnormal chromatin patterns that could be seen in carcinoma or high-grade dysplasia?", "Is there visual evidence of irregular cell shapes suggestive of malignancy or precancerous lesions?", "Are there increased numbers of mitotic figures indicating rapid cell proliferation, as might be seen in high-grade tumors?", "Do you observe changes in cell size that could be present in anaplastic tumors or dysplastic tissue?", "Is there a widespread distribution of abnormal cells that could indicate diffuse neoplastic processes or extensive dysplasia?", "Can you see an increased nuclear-to-cytoplasmic ratio in cells, as might be found in aggressive tumors or high-grade intraepithelial neoplasia?", "Are there hyperchromatic nuclei visible, which could be associated with cancer or severe dysplasia?", "Do any cells display prominent nucleoli, as might be seen in actively proliferating malignant cells or certain viral infections?", "Is there evidence of cytoplasmic vacuolization that could be due to degeneration, viral cytopathic effects, or carcinoma?", "Can you identify multinucleated cells that might be present in giant cell tumors, viral infections, or reactive conditions?", "Is there a reduction in abnormal cellular features that could suggest resolution of injury or response to treatment?", "Do you observe increased pleomorphism, as might be found in high-grade malignancies or advanced dysplasia?", "Are there abnormal cell borders visible, which could be seen in invasive carcinomas or during epithelial-mesenchymal transition?", "Is there a loss of cell polarity in areas that might correspond to carcinoma in situ or tumor progression?", "Can you see regions of increased cellular density that could indicate neoplastic proliferation or crowded dysplastic lesions?", "Are abnormal mitotic figures present, as might be seen in rapidly dividing neoplastic cells or under genotoxic stress?", "Do any cells show changes in staining properties that could be associated with malignant transformation or metaplasia?", "Is there evidence of tissue disorganization or architectural distortion that could be due to invasive cancer or severe dysplasia?"], "properties": ["Does the image show cells with irregular nuclear contours or variable nuclear shapes?", "Can you identify areas where the nuclei appear moderately or markedly enlarged compared to surrounding cells?", "Is there evidence of significant variation in nuclear shape, such as pleomorphism or elongated nuclei?", "Do any cells display coarse, clumped, or unevenly distributed chromatin patterns?", "Is there a population of cells with a noticeably increased nuclear-to-cytoplasmic ratio?", "Are prominent or enlarged nucleoli visible within any of the nuclei?", "Do some cells exhibit basophilic, vacuolated, or irregularly textured cytoplasm?", "Can you observe an increased number of mitotic figures compared to normal tissue?", "Is there moderate to high variability in the size and shape of nuclei within the image?", "Are there regions where staining appears hyperchromatic or unevenly distributed among the cells?", "Do any cells appear larger and more variable in size than typical for the tissue type?", "Is multinucleation present in any of the cells, even if only occasionally?", "Are there areas where hyperchromasia is particularly marked or intense?", "Do some cells have indistinct or poorly defined borders?", "Are abnormal mitotic figures more frequent in this image than would be expected in normal tissue?"], "relational": ["Does the image show tissue from regions such as the cervix, breast, colon, or skin that might be evaluated for abnormal cellular changes?", "Can you identify epithelial, squamous, or glandular cells displaying features that differ from normal morphology?", "Is there evidence of disrupted tissue architecture, such as loss of polarity or disordered arrangement, in the image?", "Does the image include anatomical structures like breast ducts, cervical lining, or colonic mucosa where cellular abnormalities might be assessed?", "Can you observe histological features such as nuclear enlargement, hyperchromasia, or irregular nuclear membranes in any cells present?", "Is there a region in the image where cells show variation in size and shape or an increased nuclear-to-cytoplasmic ratio?", "Does the image contain areas with abnormal mitotic figures among epithelial or glandular cells?", "Can you see a transitional zone or an area where cellular characteristics change between adjacent regions of tissue?", "Is there a sample from the reproductive, gastrointestinal, or respiratory system where abnormal cellular features could be present?", "Are there anatomical sites such as the prostate, cervix, breast, or colon in the image that might be prone to cellular abnormalities?"], "contexual_behavior": ["Does the image show evidence of increased cellular abnormality in areas affected by chronic inflammation?", "Can you identify regions where abnormal cell features are more pronounced following exposure to carcinogenic agents?", "Is there a reduction in abnormal cellular morphology after removal of a pathological stimulus in the tissue?", "Does the image display progression of abnormal cell features consistent with malignant transformation?", "Can you observe normalization of cellular architecture following successful treatment in the tissue?", "Are there signs of worsening cellular abnormalities in regions with evidence of viral infection?", "Do you see temporary abnormal cell features in areas undergoing tissue regeneration?", "Is there an increase in cellular abnormality in regions corresponding to precancerous lesions?", "Can you detect a decrease in abnormal cell morphology after cessation of toxic exposure?", "Are abnormal cell features more severe in areas where immune surveillance appears compromised?", "Do you observe fluctuations in cellular abnormality that could be associated with hormonal changes?", "Is there an increase in abnormal cell morphology in regions exposed to radiation therapy?", "Can you see regression of abnormal cellular features following anti-inflammatory therapy?", "Are abnormal cell features more prominent in tissue regions showing signs of hypoxia?", "Do you observe worsening morphological abnormalities in areas experiencing persistent cellular stress?"], "functions": ["Does the image show evidence of abnormal cellular function that could indicate an increased risk for malignant transformation?", "Can you identify areas where cells display irregular growth patterns or a loss of normal differentiation?", "Is there visual evidence of changes that might serve as a precursor to dysplasia or neoplasia, suggesting disease progression?", "Does the tissue appear to have impaired regeneration or disrupted repair, possibly due to abnormal cell cycle control?", "Are there features suggesting altered apoptosis, cell cycle dysregulation, or defects in DNA repair mechanisms?", "Can you observe increased or uncontrolled cellular proliferation contributing to tissue abnormalities?", "Is there evidence of early cellular changes that could play a role in cancer initiation or malignant transformation?", "Does the image reveal disruption in the regulation of cell growth, such as failure of normal checkpoints or signaling pathways?", "Are there signs of disrupted tissue architecture, including cellular disorganization or loss of polarity?", "Can you detect abnormal cell signaling, such as altered receptor expression or changes in intracellular communication pathways?"]}, "no_questions": {"contexual_properties": ["Can you detect differences in mucosal texture between two cervical-like structures, potentially resulting from chronic irritation, infection, or hormonal changes?", "Can you identify duplicated structures that display changes in tissue composition suggestive of infection or neoplastic processes?", "Is there an abnormal size difference between paired cervical structures that could be explained by hormonal changes, inflammation, or congenital variation?"], "properties": ["Is there visual evidence of numerous endocervical glands within the mucosa of each structure?", "Is there visual indication of non-keratinized stratified squamous epithelium on the outer surface and simple columnar epithelium lining the canal of each structure?", "Is there evidence of a septum or partial division between two cervical structures?"], "relational": ["Is there a duplicated structure, each connected to its own uterine cavity or vaginal canal?", "Does the image suggest the presence of a double uterus or bicornuate uterus?", "Can you observe any signs of a double vagina or other vaginal anomalies associated with reproductive tract duplication?"], "contexual_behavior": [], "functions": ["Is there evidence of two cervical canals that might alter menstrual flow patterns or regulation?", "Is there a feature present that could increase susceptibility to infections by providing two possible entry points for pathogens?", "Does the image reveal two cervical openings that might influence sperm migration to the uterus?"]}}, "glands": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears enlarged, which could suggest infection, inflammation, or abnormal growth?", "Is there a visible structure that seems shrunken, possibly indicating atrophy or reduced hormonal activity?", "Can you identify an area where a structure has changed color, which might be due to hemorrhage, necrosis, or pigment buildup?", "Is there evidence of swelling in a structure that could be caused by inflammation, infection, or duct blockage?", "Does the image reveal a region that might be tender or sensitive due to inflammation or infection?", "Is there a structure that appears heavier or bulkier, potentially from increased cell number or fluid accumulation?", "Can you see a structure that looks smaller than usual, possibly due to chronic disease or lack of stimulation?", "Is there a visible accumulation of fluid within a structure, suggesting duct obstruction or cyst formation?", "Does any structure appear unusually firm or hard, which could indicate fibrosis, malignancy, or chronic inflammation?", "Can you identify a cystic area within a structure, possibly resulting from duct blockage or congenital anomaly?", "Is there evidence of abnormal tissue growth, such as a mass or nodule, that could be due to neoplastic changes or hyperplasia?", "Does the image show a nodular appearance in a structure, which might be associated with chronic inflammation or multinodular changes?", "Is there a change in texture of a structure, such as increased firmness or edema, that could suggest fibrosis or neoplastic transformation?", "Can you see signs of fibrosis in a structure, possibly following chronic inflammation, injury, or autoimmune processes?", "Is there visual evidence of increased secretions, which might be linked to hyperstimulation or an endocrine disorder?", "Does any structure appear to have decreased secretions, possibly due to atrophy or hormonal deficiency?", "Is there a visible alteration in cellular composition, such as metaplastic or neoplastic changes, within a structure?", "Can you identify calcifications within a structure, which might be associated with chronic inflammation, neoplasia, or metabolic disorders?", "Is there discoloration of a structure that could be due to hemorrhage, necrosis, or pigment accumulation?", "Does the image show signs of inflammation, such as redness or swelling, possibly resulting from infection, autoimmune reaction, or injury?"], "properties": ["Does the image show a structure that could range in size from a few millimeters to several centimeters?", "Is there an object present whose weight might vary from less than a gram to around 30 grams depending on its type?", "Can you identify a structure with a tubular, acinar, or lobular shape?", "Is there a feature displaying a pale pink to reddish-brown color, possibly due to high vascularity?", "Does the image contain something with a soft, smooth, or lobulated texture?", "Can you see a structure likely composed of secretory epithelial cells or myoepithelial cells?", "Is there an object that appears well hydrated, possibly containing 70\u201380% water by mass?", "Does the image show a structure with a density similar to soft tissue, around 1.03\u20131.06 g/cm\u00b3?", "Is there an object whose tissue might maintain a slightly alkaline pH, around 7.2 to 7.4?", "Can you identify a structure that could contain 5\u201315% lipid content depending on its type?", "Does the image show an object that might have a substantial protein content, about 15\u201325% of its mass?", "Is there a structure with relatively low carbohydrate content, less than 5% of tissue mass?", "Can you see an object that might contain minor mineral content, less than 2% of its mass, including elements like calcium and potassium?", "Is there a structure whose volume could range from less than 1 mL to over 20 mL?", "Does the image show a feature that appears highly vascularized, with a dense capillary network?", "Can you identify a structure where enzyme concentration might be high, especially if it is involved in secretion?", "Is there an object that could have significant hormone concentrations, varying by physiological state?", "Does the image show a structure likely to be at core body temperature, around 36.5\u201337.5\u00b0C?", "Can you see a feature with multiple lobes or lobules, such as two lobes or several segments?", "Is there a structure that might have a high cellular density, on the order of millions to hundreds of millions of cells per cubic centimeter?"], "relational": ["Does the image show a structure that is part of the endocrine or exocrine system?", "Can you identify an object that could belong to the digestive, integumentary, or reproductive system due to its secretory function?", "Is there a visible structure that could be classified as an endocrine or exocrine type?", "Does the image contain something resembling sebaceous, sweat, or salivary tissue?", "Can you see a structure composed mainly of epithelial or connective tissue?", "Is there an object that appears to be made up of secretory cells?", "Does the image show a component that could be found in the skin, pancreas, stomach, intestines, or mammary tissue?", "Can you identify a structure associated with ducts such as those for saliva, bile, sweat, or pancreatic secretions?", "Is there a visible feature that might be located in the neck, abdomen, thorax, pelvis, or head?", "Does the image show a structure with nearby arteries, veins, or capillaries supplying it?", "Can you see evidence of lymphatic drainage or the presence of lymph nodes near a secretory structure?", "Is there an object adjacent to muscles, blood vessels, nerves, or bones that could indicate a secretory function?", "Does the image contain a structure that might interact anatomically with the brain, kidneys, liver, or reproductive organs?"], "contexual_behavior": ["Is there a structure in the image that would increase hormone secretion during activation of the hypothalamic-pituitary-adrenal axis, such as during stress?", "Can you identify an object that might show reduced secretory activity as a result of aging or cellular senescence?", "Does the image contain a structure that could fail to produce hormones due to immune-mediated tissue destruction, as seen in autoimmune diseases?", "Is there an object that might alter its secretion in response to infection through immune signaling or inflammatory mediators?", "Can you see a structure that would increase enzyme release after food intake as part of the digestive process?", "Is there an object that would decrease its output during dehydration to help conserve body fluids?", "Does the image include a structure that could show impaired function due to hormonal imbalance or structural abnormalities associated with endocrine disorders?", "Is there a structure that might overproduce hormones in the presence of neoplastic cells, as in tumor conditions?", "Can you identify an object that would reduce its secretion during chronic inflammation due to persistent cytokine exposure?", "Is there a structure that would increase its activity during puberty in response to rising levels of gonadotropins and sex steroids?", "Does the image show a structure that could fail to regulate metabolism due to insufficient thyroid hormone production, as in hypothyroidism?", "Is there an object that might alter its function in response to circadian rhythms, showing time-dependent hormonal release patterns?", "Can you see a structure that would decrease its secretion when exposed to medications that inhibit glandular activity or block signaling pathways?", "Is there a structure that would increase its activity during pregnancy to support fetal development and maternal physiological changes?", "Does the image contain an object that might fail to respond to regulatory signals due to insulin resistance or beta-cell dysfunction, as seen in diabetes?", "Is there a structure that could show reduced function after radiation exposure due to cellular damage and loss of secretory capacity?", "Can you identify an object that would increase sweat production in high temperatures to facilitate thermoregulation?", "Is there a structure that would decrease saliva secretion during stress because of sympathetic nervous system activation?", "Does the image show a structure that could alter its secretory patterns due to sleep deprivation and disrupted hormonal rhythms?", "Is there an object that would increase its output in response to physical exercise to support metabolic demands and maintain homeostasis?"], "functions": ["Is there a structure in the image that appears to be responsible for synthesizing and secreting substances such as hormones or enzymes?", "Can you identify an object that might regulate hormone secretion through feedback mechanisms involving the nervous or endocrine systems?", "Does the image show a structure that could help maintain internal balance by adjusting the release of hormones or other substances in response to physiological changes?", "Is there an object present that may contribute to metabolic processes by producing hormones or enzymes that control metabolic pathways?", "Can you see a structure that might assist in the body's stress response by releasing hormones like cortisol or adrenaline?", "Does the image contain a structure that plays a key role in digestion by secreting digestive enzymes or fluids into the gastrointestinal tract?", "Is there a visible object that could support immune defense by producing substances such as antibodies or antimicrobial peptides?", "Can you identify a structure that might control growth and development by secreting growth hormones or other regulatory factors?", "Does the image show an object involved in reproductive processes by producing sex hormones or reproductive fluids?", "Is there a structure present that could regulate fluid and electrolyte balance by releasing hormones such as aldosterone or antidiuretic hormone?", "Can you see an object that might influence blood pressure by secreting hormones affecting vascular tone or fluid retention?", "Is there a structure in the image that participates in temperature regulation by secreting sweat or modulating metabolic rate?", "Does the image contain an object involved in detoxification by producing enzymes or substances that neutralize toxins?", "Can you identify a structure that affects energy balance by releasing hormones that regulate appetite, metabolism, or energy storage?", "Is there a visible object that could play a role in tissue repair and regeneration by secreting growth factors or cytokines?"]}, "no_questions": {"contexual_properties": ["Does the image show a region of the stomach with unusually thickened mucosa?", "Are the rugae of the stomach visibly enlarged or hypertrophied on the image?", "Can you identify areas where the gastric folds appear enlarged or more prominent than normal?"], "properties": [], "relational": ["Does the image suggest involvement of lymphatic structures such as gastric or celiac lymph nodes near the stomach?", "Are there any visible differences in regions supplied by the left gastric artery, right gastric artery, or short gastric arteries?", "Are there any notable interactions or proximity between the stomach and adjacent structures like the duodenum, pancreas, or lesser omentum?"], "contexual_behavior": [], "functions": ["Does the image suggest abnormal regulation of gastric hormones, such as changes in the appearance of hormone-producing regions?", "Can you identify any abnormalities that might reflect altered production of digestive enzymes like pepsinogen?", "Is there visual evidence of delayed gastric emptying or abnormal motility patterns in the stomach?"]}}}
[ { "answer": "no", "extracted_concepts": [ "palmar creases" ], "question": "is normal palmar creases present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "esophagus", "extracted_concepts": [ "esophagus" ], "question": "what is present?" }, { "answer": "varices", "extracted_concepts": [ "varices" ], "question": "what is present?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [], "question": "is very good example present?" }, { "answer": "esophagus", "extracted_concepts": [ "esophagus" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "esophagus" ], "question": "is esophagus present?" }, { "answer": "no", "extracted_concepts": [ "acrocyanosis" ], "question": "is acrocyanosis present?" }, { "answer": "varices", "extracted_concepts": [ "varices" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "varices" ], "question": "is varices present?" } ]	["palmar creases", "esophagus", "acrocyanosis", "gastrointestinal", "gastrointestinal system", "varices"]	{"palmar creases": {"yes_questions": {"contexual_properties": ["Does the image show lines on the palm that appear deeper, possibly indicating repeated hand use, aging, or skin thickening?", "Are there areas on the palm where the lines are less visible, which could suggest swelling, skin thinning, or congenital absence?", "Can you observe any color changes in the palm's lines, such as redness or bluish discoloration, that might indicate inflammation, cyanosis, or vascular issues?", "Is there evidence of widened lines on the palm, which could be due to chronic swelling, lymphedema, or scleroderma?", "Do you see an increased number of lines on the palm, potentially related to genetic syndromes or excessive skin folding?", "Are any of the palm's lines fused together, which may be a feature of chromosomal conditions like Down syndrome?", "Is there redness or signs of inflammation along the palm's lines, suggesting dermatitis, allergic reactions, or infection?", "Do the palm's lines appear unusually pale, possibly indicating anemia, poor blood flow, or Raynaud's phenomenon?", "Are there interruptions or breaks in the palm's lines that could be due to trauma, scarring, or skin disease?", "Can you identify abnormal patterns in the palm's lines that might be associated with congenital or connective tissue disorders?", "Are the palm's lines more prominent than usual, which could result from dehydration, weight loss, or increased skin turgor?", "Do the lines on the palm appear shallower, as might be seen in newborns, swelling, or skin atrophy?", "Is there visible thickening of the palm's lines, possibly due to scleroderma, chronic eczema, or callus formation?", "Do the palm's lines look less regular, which could be a sign of genetic disorders, trauma, or skin diseases?", "Is there a single transverse line across the palm, a feature often associated with simian crease and Down syndrome?"], "properties": ["Does the image show a hand with three major intersecting lines arranged in characteristic locations?", "Can you identify curved or arched lines following the contours of the palm?", "Is there evidence of both transverse and longitudinal lines on the palm?", "Does the image display lines that are approximately 4 to 8 centimeters in length, depending on hand size?", "Are there visible lines on the palm that appear 1 to 3 millimeters wide?", "Can you see lines that are slightly lighter or similar in color to the surrounding palmar skin?", "Are the lines on the palm smooth and slightly indented compared to adjacent skin?", "Does the image show lines that are spaced about 1 to 2 centimeters apart?", "Is there a single prominent transverse line across the palm, which is uncommon in the general population?", "Do the lines on the palm appear more pronounced or deeper, possibly indicating age-related changes?", "Can you observe that the skin within the lines is composed of multiple layers, such as epidermis and dermis?", "Does the skin at the lines appear to maintain high elasticity, allowing for hand movement?", "Is there a moderate or slightly elevated moisture level visible along the palm lines compared to the rest of the palm?", "Do the lines on the palm show uniform or slightly lighter pigmentation relative to the surrounding skin?"], "relational": ["Does the image show surface markings on the anterior aspect of the hand?", "Can you identify skin folds on the palm that correspond to joint movement?", "Is there evidence of features involving both the epidermis and dermis layers of the skin?", "Are there visible structures located overlying the metacarpal bones or phalanges?", "Can you see markings that are adjacent to the palmar aponeurosis or flexor tendons?", "Is there a region on the palm near the flexor digitorum superficialis or thenar muscles?", "Does the image show an area supplied by the superficial palmar arch or digital arteries?", "Are there visible features in proximity to the median or ulnar nerves?", "Can you identify markings that are related to the metacarpophalangeal or interphalangeal joints?", "Is there evidence of connective tissue, such as the palmar aponeurosis or subcutaneous connective tissue, underlying visible skin folds?"], "contexual_behavior": ["Does the image show any features of the hand that are less prominent, which could be associated with genetic disorders such as ectodermal dysplasia or certain forms of congenital ichthyosis?", "Can you identify any altered patterns in the lines of the palm that might suggest chromosomal abnormalities like Down syndrome, Turner syndrome, or Klinefelter syndrome?", "Is there evidence of abnormal formation of palm lines that could indicate disrupted fetal development, as seen in conditions like amniotic band syndrome or connective tissue disorders?", "Do the visible lines on the palm show changes in configuration that could be related to connective tissue diseases such as scleroderma or systemic lupus erythematosus?", "Are there any palm features that appear deeper or more pronounced, which might be consistent with dermatological conditions like palmoplantar keratoderma?", "Does the image show a loss of definition in the palm lines that could be due to swelling or edema, possibly from heart failure or nephrotic syndrome?", "Is there a single transverse line across the palm, sometimes referred to as a simian crease, which can be associated with Down syndrome?", "Can you observe any abnormal branching patterns in the palm lines that might indicate congenital malformations such as those seen in Holt-Oram syndrome or other limb development disorders?", "Do the palm lines appear less visible, which could be a sign of severe dehydration affecting skin turgor and elasticity?", "Is there any evidence of altered palm line patterns that could result from trauma, scarring, burns, or surgical procedures on the hand?"], "functions": ["Does the image show features that increase the flexibility of the palmar skin during hand movements?", "Can you identify structures that allow the skin of the palm to fold efficiently, enabling smooth flexion and extension of the fingers?", "Is there evidence of adaptations that enhance grip by permitting the skin to conform closely to objects for improved friction and grasp stability?", "Do you observe segmentations on the palmar surface that contribute to flexibility and protect against excessive stretching or tearing during movement?", "Are there visible lines that act as natural hinges, accommodating repeated flexion and extension while reducing mechanical stress on the skin?", "Does the image display features that are functionally significant for manual dexterity and enable precise, coordinated finger movements required for fine motor tasks?", "Can you see evidence of structures that help reduce skin tension during hand movements by distributing mechanical forces and minimizing strain on the palmar skin?"]}, "no_questions": {"contexual_properties": ["Does the image reveal changes in bone density that might be related to metabolic disorders, neoplastic processes, or trauma?", "Is there abnormal calcification present in a bone structure, possibly due to chronic inflammation, metabolic disorder, or trauma?", "Does the image show a region of bone with increased porosity, which could suggest a metabolic bone disease such as osteomalacia or Paget\u2019s disease?"], "properties": ["Can you see a structure that appears flat or gently curved, following the contour of the cranial vault?", "Is there evidence of a bone layer with low porosity, typically less than 10%?", "Is there a bone layer that could contain type I collagen making up about 20\u201330% of its organic matrix?"], "relational": ["Can you identify a layer that lies adjacent to both the diplo\u00eb and the dura mater?", "Does the image include a feature that separates the diplo\u00eb from the cranial cavity?", "Does the image show a component of the cranial bones that forms part of the skull?"], "contexual_behavior": ["Does the image suggest any functional alteration of a cranial bone layer, such as might occur during cranial surgery or trauma repair?", "Can you see any evidence of increased bone resorption or osteoclastic activity in response to chronic inflammation?", "Is there a bony layer whose barrier function might be compromised due to infection or inflammation?"], "functions": ["Does the image contain a structure that reinforces the inner aspect of the skull to help prevent fractures?", "Does the image include a component of cranial bone that appears to maintain bone density and contribute to overall skull durability?", "Is there a hard barrier visible that could help shield the brain from external forces or injuries?"]}}, "esophagus": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a muscular, cylindrical tube with a diameter of about 2 to 3 centimeters?", "Can you identify a structure that is approximately 25 to 30 centimeters in length in adults?", "Is there a tubular structure with a wall thickness of about 3 to 4 millimeters?", "Does the image contain a lining that appears pale pink and smooth?", "Can you see a moist, smooth surface consistent with a mucosal lining?", "Is there a structure composed of both skeletal muscle in its upper portion and smooth muscle in its lower portion?", "Does the image show a tube with distinct layers, such as mucosa, submucosa, muscularis propria, and adventitia?", "Can you identify a structure that contains stratified squamous epithelial cells and smooth muscle cells?", "Is there evidence of a moderate vascular network, such as submucosal capillaries, within a tubular structure?", "Does the image suggest the presence of a high density of nerve fibers in the myenteric or submucosal plexuses?", "Can you see a structure whose average weight would be about 25 to 30 grams?", "Is there a tubular organ with a water content of approximately 70 to 75 percent by weight?", "Does the image show a structure with collagen making up about 15 to 20 percent of its dry weight?", "Is there evidence of elastic fibers comprising around 2 to 5 percent of the dry weight in a tubular structure?", "Can you identify a structure with a moderate amount of glycogen in its epithelial lining?", "Does the image show a tubular organ with low lipid content, mainly in cell membranes?", "Is there a structure whose density would be close to 1.05 grams per cubic centimeter?", "Can you see a tubular organ whose temperature would be similar to core body temperature, around 36 to 37 degrees Celsius?", "Does the image contain a structure with a pH typically between 4 and 7?"], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify a tubular structure that connects the pharynx to the stomach?", "Is there an object that passes through the neck, thorax, and upper abdomen?", "Does the image contain a structure composed of mucosal, submucosal, muscular, and connective tissue layers?", "Can you see a structure that is surrounded by the trachea, aorta, or vertebral column?", "Is there an object that receives blood supply from the inferior thyroid artery, bronchial arteries, or left gastric artery?", "Does the image show a structure innervated by the vagus nerve or the sympathetic trunk?", "Can you identify a region where the pharynx transitions into a sphincter at the upper end of a tubular structure?", "Is there a visible junction where a tubular structure meets the stomach, forming a lower sphincter?", "Does the image display a wall with distinct layers such as mucosa, submucosa, muscularis propria, and adventitia?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that serves as a conduit for transporting food or liquids from the throat to the stomach?", "Can you identify an anatomical feature that advances ingested material toward the stomach through wave-like muscular contractions?", "Does the image show a region where peristalsis might occur to move a swallowed bolus?", "Is there evidence of a barrier that could prevent stomach contents from moving back toward the throat?", "Can you see a structure that would coordinate with both the pharynx and the stomach during the process of eating?", "Is there an anatomical feature that could help protect the airway during swallowing by working in conjunction with the epiglottis?", "Does the image contain a region that would facilitate the passage of both liquids and solids by adjusting muscular activity?", "Can you identify a structure whose motility might be regulated by the enteric nervous system or autonomic input?", "Is there any indication of tissue that could respond to irritation with inflammation or increased mucus production?"]}, "no_questions": {"contexual_properties": ["Is there a thickened basement membrane present, possibly indicating chronic inflammation or fibrosis?", "Does the section show decreased staining intensity that could result from tissue degeneration or poor fixation?", "Does the image reveal increased submucosal edema, as could occur in acute inflammation or allergic reactions?"], "properties": ["Does the image show a tissue layer that could be identified by a specific staining technique?", "Can you identify an area where the contrast between different cell types is enhanced, possibly due to a histological stain?", "Does the image contain a region where the arrangement of epithelial cells is clearly highlighted by staining?"], "relational": ["Does the image show a boundary where the mucosa lies superficial to the submucosa, separated by a thin muscular layer?", "Are sublayers such as surface epithelium, lamina propria, and muscularis mucosae distinguishable in the image?", "Can you identify epithelial types such as simple columnar, stratified squamous, or pseudostratified epithelium?"], "contexual_behavior": ["Is there an increased number of goblet cells or enhanced mucin production visible, which could be associated with infection?", "Are there indications of increased mitotic figures or abnormal epithelial architecture that would suggest altered epithelial regeneration after injury?", "Does the image show evidence of disrupted epithelial integrity or loss of tight junctions, which could indicate reduced barrier function during inflammation?"], "functions": ["Are there histopathological features visible that could assist in diagnosing mucosal diseases, such as dysplasia, inflammation, or abnormal mucin accumulation?", "Is there visual evidence of biological processes like epithelial turnover, inflammation, or mucin production within the tissue section?", "Can you identify goblet cells or assess secretory activity based on the staining patterns present in the mucosal layer?"]}}, "acrocyanosis": {"yes_questions": {"contexual_properties": ["Does the image show an area where skin color appears more intense or bluish in a cold environment?", "Is there a region where the skin displays a mottled or patchy appearance, suggesting uneven blood flow?", "Can you identify an area that looks swollen, possibly due to prolonged reduced circulation?", "Is there evidence of delayed capillary refill in any visible extremity, indicating poor perfusion?", "Does any part of the image suggest increased sweating or moisture in regions with color changes?", "Is there a visible area where the skin appears thicker, possibly due to chronic changes?", "Can you see a region that might feel colder to the touch, based on its appearance and context?", "Is there a part of the image where the skin color intensity varies with apparent temperature differences or emotional stress cues?", "Does any area appear to be affected by numbness, as suggested by posture or lack of movement?", "Is there a visible region where the affected area is larger, possibly due to more extensive or prolonged vasospasm?", "Can you identify an area where the skin color improves or returns to normal in regions that appear to be warmed?", "Is there evidence of peripheral cyanosis, such as bluish discoloration in the extremities?", "Does any region show signs of hyperhidrosis, such as excessive moisture in areas with color changes?", "Is there a visible indication of chronicity, such as persistent discoloration or skin changes in the same area?"], "properties": ["Does the image show areas of skin with a bluish or cyanotic appearance?", "Can you identify regions that appear cool or have decreased temperature compared to surrounding areas?", "Is there visible evidence of moist or sweaty skin in any of the extremities?", "Do you observe mild to moderate discoloration suggestive of cyanosis?", "Is there any indication that capillary refill time in the affected areas is normal or only slightly prolonged?", "Do the affected regions appear to have normal oxygen saturation based on visual cues?", "Is the color change in the skin persistent rather than transient?", "Are the discolored areas distributed symmetrically on the distal parts of the extremities?", "Does the image suggest that the skin changes are mild and not associated with ulceration or tissue damage?", "Is there evidence that the observed findings are more likely in an adolescent or young adult individual?"], "relational": ["Does the image show any regions of the body that are part of the cardiovascular, integumentary, or peripheral vascular systems?", "Are there visible changes in the fingers, toes, hands, or feet?", "Can you identify any signs involving small arteries, arterioles, capillaries, or venules in the extremities?", "Is there evidence of altered appearance in the dermis, subcutaneous tissue, or vascular endothelium of distal regions?", "Does the image suggest impaired peripheral circulation with reduced oxygen delivery to tissues farthest from the center of the body?", "Are there visible changes in the epidermis, dermis, or subcutaneous layer of the extremities?", "Can you see structures such as peripheral veins, peripheral arteries, or capillary networks connecting distal regions to the central circulatory system?", "Is there an area displaying bluish discoloration, cool temperature, or moist skin?", "Do the upper limbs, lower limbs, or distal extremities show any distinguishing features?", "Are there visible interactions between the affected regions and the nervous, endocrine, or musculoskeletal systems?"], "contexual_behavior": ["Does the image show any changes in the appearance of the extremities that could be influenced by exposure to cold temperatures?", "Is there evidence of peripheral features that might improve after warming or exposure to a warm environment?", "Can you identify any signs that could become more pronounced during emotional stress or sympathetic nervous system activation?", "Does the image suggest changes that might decrease in intensity following physical activity or increased circulation?", "Is there a visible feature that appears persistent, even after removal of an apparent trigger, possibly indicating an underlying vascular or systemic disease?", "Are there signs that could be more severe in the context of peripheral vascular disease or impaired blood flow?", "Does the image suggest reduced intensity of symptoms that might be expected in a warm climate?", "Can you see features that might be more persistent in individuals with connective tissue disorders or microvascular dysfunction?", "Is there evidence of changes that could worsen during hypotension or shock due to reduced perfusion?", "Does the image show features that might improve with enhanced cardiac output or increased peripheral blood flow?", "Are there signs that appear less responsive to temperature changes, possibly indicating a chronic condition?", "Can you identify features that could increase in frequency during anxiety or panic attacks due to sympathetic response?", "Is there evidence of improvement in symptoms that might follow successful treatment of an underlying endocrine disorder affecting vascular tone?", "Does the image suggest increased severity of findings in the presence of anemia or reduced oxygen-carrying capacity?", "Are there features that fail to improve after rewarming, possibly indicating arterial occlusion and persistent obstruction to blood flow?"], "functions": ["Does the image show persistent bluish discoloration and coolness of the skin, especially on the hands or feet?", "Can you identify signs of reduced blood flow in the small vessels of the extremities, such as color changes or coolness?", "Is there evidence of lower skin temperature in areas with visible discoloration, suggesting limited warm arterial blood supply?", "Do you observe any regions where impaired oxygen delivery to peripheral tissues is indicated by a bluish tint?", "Are there visual cues of constricted arterioles or sluggish capillary circulation in the skin of the extremities?", "Does the image show chronic coolness and discoloration in the hands or feet, suggesting decreased tissue perfusion?", "Can you see persistent cyanosis in superficial tissues that might indicate chronic hypoxia without obvious tissue damage?", "Is there evidence that the discoloration worsens in response to cold exposure or improves with warming?", "Do you observe features suggesting a protective response to cold, such as reduced heat loss through peripheral vasoconstriction?", "Are there signs of impaired capillary function, such as slowed blood flow or increased deoxygenated blood in the skin?"]}, "no_questions": {"contexual_properties": ["Do you observe a lesion with color changes that might indicate bleeding, clot formation, or tissue necrosis?", "Is there an ulcerated area where a mucosal tear has deepened to expose the submucosa or muscularis?", "Do you see a lesion that is less visible, suggesting healing and coverage by new epithelial tissue?"], "properties": ["Can you identify an area where bleeding is prominent and appears to originate from a linear mucosal defect?", "Does the image reveal disrupted mucosal epithelium with possible exposure of submucosal vessels?", "Can you identify a structure measuring between 0.5 and 4 centimeters in length and 2 to 10 millimeters in width?"], "relational": ["Does the image show a lesion located at or just below the junction between the esophagus and stomach?", "Can you identify a disruption involving the mucosal or submucosal layers of the gastrointestinal tract near the cardia?", "Can you see a disruption of the esophageal or gastric mucosa near the gastroesophageal junction?"], "contexual_behavior": ["Is there a region of the esophagus that looks weakened and more vulnerable to further mechanical trauma?", "Is there a tear that appears to be affected by ongoing mechanical stress, such as from vomiting or retching, potentially impairing healing?", "Does the image suggest impaired mucosal protection, possibly in the context of alcohol exposure?"], "functions": ["Can you see features that could explain pain or transient difficulty in swallowing?", "Can you identify an area where the mucosal barrier appears compromised, potentially increasing susceptibility to acid exposure or infection?", "Does the image show evidence of mucosal disruption at the gastroesophageal junction?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": [], "properties": ["Are there any structures that appear pale yellow or chalky white in color?", "Do you see evidence of calcification occurring with moderate to high frequency, especially in chronic-appearing lesions?", "Does the image show any areas that range in size from a few millimeters to several centimeters?"], "relational": ["Does the image show any regions within adipose or subcutaneous tissue that appear abnormal?", "Can you see any features consistent with saponification lesions within fatty tissue?", "Can you identify any abnormality near capillaries or small arteries that suggests vascular injury or inflammation?"], "contexual_behavior": [], "functions": ["Are there regions where immune cells like macrophages or neutrophils appear to be recruited to a site of injury?", "Can you see signs of adipose tissue breakdown, such as regions suggestive of lipolysis or phagocytosis of fat cells?", "Is there visual evidence of macrophage interaction with necrotic material or modulation of the inflammatory response in the tissue?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify two major parallel vessels responsible for arterial outflow and venous return?", "Does the image show a structure that is part of the cardiovascular system?", "Is there a large artery from which the coronary arteries, brachiocephalic trunk, left common carotid artery, or left subclavian artery branch off?"], "contexual_behavior": [], "functions": ["Is there a vessel that expands to accommodate increased blood volume and pressure during heightened cardiac output?", "Is there a vessel that supplies blood to the coronary arteries via openings just above a heart valve?", "Does the image show a structure responsible for transporting oxygen-rich blood from the heart to the rest of the body?"]}}, "varices": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure in the distal esophagus or proximal stomach that appears tortuous and elongated?", "Can you identify any bluish or purplish serpentine vessels within the gastrointestinal tract?", "Does the image show any veins with a diameter between 3 mm and 10 mm?", "Are there any nodular, beaded, or grape-like surface features visible on vascular structures?", "Can you see any vessels with wall thickness less than 1 millimeter?", "Is there evidence of multiple dilated veins, possibly more than three, in the same region?", "Are there vascular structures that could be classified as small (<5 mm), medium (5\u201310 mm), or large (>10 mm) based on their size?", "Do any elongated vessels display red wale markings or cherry red spots on their surface?", "Is there a visible vessel whose length appears to be several centimeters?", "Can you see any vascular structures with a thin wall composed of endothelium, smooth muscle, and connective tissue?", "Are there veins in the image whose size or appearance suggests an increased risk of rupture, particularly if they are larger than 5 mm in diameter?", "Does the image show any dilated veins with a beaded or grape-like appearance in the gastrointestinal tract?"], "relational": ["Does the image show any abnormal vascular structures associated with the circulatory or digestive systems?", "Can you identify dilated veins in regions such as the esophagus, stomach, or rectum?", "Is there evidence of vascular changes in proximity to the mucosa, submucosa, or muscularis layer?", "Does the image contain veins that could be part of the portal venous or systemic venous systems?", "Can you see vascular structures surrounded by connective tissue, epithelial tissue, or smooth muscle?", "Is there a visible indication of collateral vessel formation or increased venous pressure?", "Does the image suggest the presence of portal-systemic anastomoses?", "Can you identify vascular abnormalities in organs like the esophagus, stomach, liver, or rectum?", "Is there any sign of vascular structures that might be affected by portal hypertension?", "Does the image show vascular features that interact with both the digestive and circulatory systems?"], "contexual_behavior": ["Does the image show dilated veins that could result from sustained elevation of portal venous pressure?", "Can you identify structures that might be prone to bleeding if intravascular pressure exceeds vessel wall strength?", "Is there evidence of venous dilation that could be associated with high portal pressure?", "Do any vessels appear thinned or weakened, suggesting chronic distension or inflammation?", "Can you see signs of vessel wall fragility that might be expected in the setting of liver cirrhosis and elevated portal pressure?", "Is there a structure that could demonstrate impaired blood flow regulation due to endothelial dysfunction?", "Do any vessels appear excessively stretched, indicating increased wall tension from persistent elevated venous pressure?", "Can you identify veins that seem unable to compensate for increased blood flow, possibly due to insufficient collateral circulation?", "Is there visual evidence of acute gastrointestinal bleeding that could further compromise vessel integrity?", "Do any vessels appear less responsive to vasoactive changes, as might occur in advanced liver disease?", "Can you see signs of venous congestion that might be associated with hepatic decompensation?", "Are there vessels whose structure or blood flow appears altered, potentially as a result of endoscopic treatment like band ligation or sclerotherapy?", "Do any veins seem to have reduced mechanical strength, possibly due to chronic hypertension or repeated injury?", "Is there evidence of impaired hemostasis, such as abnormal clotting, that could increase the risk of bleeding from these vessels?", "Can you identify increased shunting of blood through collateral pathways, as might occur in chronic liver disease?", "Are there changes in collateral vessel flow or structure that could be explained by portal vein thrombosis?"], "functions": ["Does the image show any abnormally dilated veins that could indicate a pathological structure?", "Can you identify vessels that appear to disrupt normal blood flow, possibly causing turbulence or increasing the risk of rupture?", "Is there evidence of fragile vascular structures that might predispose to bleeding complications?", "Does the image suggest impaired pressure regulation in the venous system, such as signs of venous hypertension?", "Can you see vascular changes that might compromise tissue oxygenation or suggest local ischemia due to impaired perfusion?", "Is there visual evidence of collateral circulation forming as a bypass pathway, potentially due to portal hypertension?", "Does the image contain vascular features that could serve as markers of advanced chronic liver disease or indicate disease progression?", "Can you identify collateral veins that appear to alter normal venous drainage by diverting blood away from usual pathways?", "Is there any indication of venous dilation, remodeling, or vessel wall weakness in the image?", "Does the image show persistent dilation of vessels that might reflect abnormal remodeling or impaired repair mechanisms?"]}, "no_questions": {"contexual_properties": ["Can you identify chalky deposits that may result from saponification and calcium soap formation?", "Is there a region that appears encapsulated by a fibrous capsule, suggesting a chronic phase of healing?", "Is there a structure that appears cystic, possibly resulting from liquefaction and tissue breakdown?"], "properties": ["Is there an area that might have a slightly alkaline environment due to the presence of calcium soaps?", "Does the image show a lesion containing a moderate to numerous number of multinucleated giant cells?", "Is there an area where inflammatory cells make up a significant portion of the tissue?"], "relational": ["Can you observe any features consistent with lipid breakdown or saponification within adipose tissue?", "Is there a region in the image where adipocytes appear disrupted or replaced by other cell types such as macrophages or multinucleated giant cells?", "Does the image show changes in tissues that could impact the integumentary, digestive, or endocrine systems?"], "contexual_behavior": ["Can you identify regions where wound healing appears impaired, especially after trauma, due to necrotic fat impeding granulation?", "Can you see areas where fat storage capacity seems reduced, possibly replaced by fibrous or calcified tissue?", "Can you identify the formation of oil cysts or fibrous tissue where liquefied fat may have been walled off or replaced by scar tissue?"], "functions": ["Does the image show evidence of a process involving enzymatic breakdown of lipids and inflammation?", "Can you see signs of fibrosis or increased collagen deposition indicating tissue remodeling?", "Is there an area where cell death, inflammation, or changes in the extracellular matrix are apparent?"]}}}
[ { "answer": "excellent photo typical adenocarcinoma extending through muscularis to serosa", "extracted_concepts": [ "muscularis", "serosa", "adenocarcinoma" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "typical adenocarcinoma", "muscularis", "serosa" ], "question": "does this image show excellent photo typical adenocarcinoma extending through muscularis to serosa?" }, { "answer": "no", "extracted_concepts": [ "muscularis", "typical tuberculous exudate", "excellent photo typical adenocarcinoma", "serosa" ], "question": "does typical tuberculous exudate show excellent photo typical adenocarcinoma extending through muscularis to serosa?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "mucoepidermoid carcinoma" ], "question": "is mucoepidermoid carcinoma present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "colon" ], "question": "is colon present?" }, { "answer": "no", "extracted_concepts": [ "edema" ], "question": "is edema present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" } ]	["muscularis", "edema", "typical tuberculous exudate", "mucoepidermoid carcinoma", "adenocarcinoma", "excellent photo typical adenocarcinoma", "colon", "gastrointestinal", "typical adenocarcinoma", "serosa", "gastrointestinal system"]	{"muscularis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a tissue layer with a thickness between 1 and 5 millimeters?", "Can you identify a structure composed mainly of smooth muscle fibers, connective tissue, blood vessels, and nerves?", "Is there a region where smooth muscle fibers predominate, with possible presence of skeletal muscle fibers in specific locations?", "Does the image display a layer organized into an inner circular and an outer longitudinal arrangement of muscle?", "Can you see a tissue with a cell density that could range from 10,000 to 50,000 cells per cubic millimeter?", "Is there a structure exhibiting a pale pink to light red coloration, possibly due to vascularity and muscle content?", "Does the image include a tissue with a water content close to 70% by weight?", "Can you identify a region where collagen makes up about 5 to 15% of the dry weight?", "Is there a tissue layer with less than 5% elastic fiber content by dry weight?", "Does the image show a structure likely to have a pH between 7.2 and 7.4, indicating physiological neutrality?", "Can you see a tissue with a protein concentration of approximately 15 to 20% of its wet weight?", "Is there a region with a temperature consistent with core body temperature, around 36.5 to 37.5\u00b0C?", "Does the image display a tissue with a firm and elastic texture due to its muscle and connective tissue composition?", "Can you identify a layer with a density close to 1.05 grams per cubic centimeter?", "Is there a structure where the proportion of smooth muscle to connective tissue is about 80% to 20%?"], "relational": ["Does the image show a structure that is part of the digestive, urinary, or reproductive system and contains a distinct muscle layer?", "Can you identify a layer situated between the submucosa and the serosa or adventitia in any of the organs present?", "Is there a visible boundary external to the submucosa and internal to the serosa within any organ wall?", "Does the image contain an organ such as the esophagus, stomach, intestines, ureter, or bladder that possesses a prominent muscle layer?", "Can you see a layer composed primarily of smooth muscle tissue, possibly with some connective tissue?", "Is there a structure encircling the lumen of the gastrointestinal tract, ureter, or a blood vessel?", "Does the image reveal muscle fibers arranged in circular or longitudinal orientations within an organ wall?", "Can you identify a region that may contain both smooth and, in some locations, skeletal muscle fibers?", "Is there evidence of nerves or plexuses, such as the myenteric (Auerbach's) plexus, associated with a muscle layer in the organ wall?", "Does the image show a muscle layer in anatomical regions like the pharynx, esophagus, stomach, small intestine, large intestine, ureter, or bladder?"], "contexual_behavior": [], "functions": ["Does the image show a layer responsible for generating coordinated contractions that facilitate movement within the digestive tract?", "Can you identify a structure that enables propulsion of gastrointestinal contents through rhythmic contractions?", "Is there evidence of alternating circular and longitudinal muscle layers that mix and propel food?", "Does the image contain a feature that initiates and sustains peristaltic waves for food transit?", "Can you see a layer involved in regulating the passage of digestive contents by controlling sphincters at key junctions?", "Is there a structure that physically breaks down food through churning and mixing actions?", "Does the image reveal a component that controls sphincter function by contracting or relaxing muscle fibers to open or close passageways?", "Can you identify a layer that responds to neural or hormonal signals by adjusting contraction patterns?", "Is there a muscular layer providing structural support and maintaining the integrity of digestive organs?", "Does the image show evidence of coordinated contractions ensuring effective mixing, propulsion, and timing of digestive processes?"]}, "no_questions": {"contexual_properties": ["Is there evidence of tissue disorganization or architectural distortion that could be due to invasive cancer or severe dysplasia?", "Are there hyperchromatic nuclei visible, which could be associated with cancer or severe dysplasia?", "Can you see an increased nuclear-to-cytoplasmic ratio in cells, as might be found in aggressive tumors or high-grade intraepithelial neoplasia?"], "properties": ["Can you identify areas where the nuclei appear moderately or markedly enlarged compared to surrounding cells?", "Does the image show cells with irregular nuclear contours or variable nuclear shapes?", "Is there a population of cells with a noticeably increased nuclear-to-cytoplasmic ratio?"], "relational": ["Does the image contain areas with abnormal mitotic figures among epithelial or glandular cells?", "Are there anatomical sites such as the prostate, cervix, breast, or colon in the image that might be prone to cellular abnormalities?", "Can you see a transitional zone or an area where cellular characteristics change between adjacent regions of tissue?"], "contexual_behavior": ["Does the image display progression of abnormal cell features consistent with malignant transformation?", "Do you see temporary abnormal cell features in areas undergoing tissue regeneration?", "Are abnormal cell features more prominent in tissue regions showing signs of hypoxia?"], "functions": ["Does the tissue appear to have impaired regeneration or disrupted repair, possibly due to abnormal cell cycle control?", "Are there features suggesting altered apoptosis, cell cycle dysregulation, or defects in DNA repair mechanisms?", "Does the image show evidence of abnormal cellular function that could indicate an increased risk for malignant transformation?"]}}, "edema": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region where tissue appears swollen due to increased fluid volume?", "Can you identify an area that might contain fluid with a clear or pale yellow appearance?", "Is there evidence of swelling in a dependent area, such as the lower limbs or sacral region?", "Does the image suggest the presence of tissue with increased water content, possibly exceeding 80% of its weight?", "Can you see a region where the fluid accumulation could range from several hundred milliliters to several liters?", "Is there an area that might contain fluid with a composition similar to plasma, including water, electrolytes, and protein?", "Does the image show swelling that could be due to fluid with a sodium concentration similar to plasma (approximately 135\u2013145 mmol/L)?", "Can you identify a region where the fluid might have a protein content consistent with either transudate (less than 3 g/dL) or exudate (greater than 3 g/dL)?", "Is there evidence of swelling where the fluid could have a specific gravity less than 1.015 or greater than 1.015, suggesting transudate or exudate?", "Does the image suggest the presence of fluid with a neutral to slightly alkaline pH, around 7.4?", "Can you see an area where the fluid's osmolarity might be similar to plasma, about 275\u2013295 mOsm/kg?", "Is there swelling in a region where the chloride concentration of the fluid could be close to plasma levels (around 98\u2013106 mmol/L)?", "Does the image show tissue that might contain fluid with a glucose concentration similar to plasma (approximately 70\u2013100 mg/dL)?", "Can you identify an area where the temperature of the accumulated fluid would likely reflect body temperature (36\u201337\u00b0C)?", "Is there a region where the clarity of the fluid could help distinguish between transudate (clear, non-turbid) and exudate (cloudy)?", "Does the image suggest a rate of fluid accumulation that could vary from several milliliters to liters per day depending on the underlying cause?"], "relational": ["Does the image show abnormal fluid accumulation in subcutaneous tissue or mucous membranes?", "Can you identify swelling in regions such as the lower limbs, ankles, or periorbital area?", "Is there evidence of fluid buildup in interstitial tissue or body compartments like the pleural or peritoneal cavity?", "Does the image display changes in organs such as the lungs, brain, liver, or kidneys that could indicate structural impact from excess fluid?", "Can you see signs of impaired lymphatic drainage, such as distended lymphatic vessels or lymph nodes?", "Is there visible swelling that could be related to lymphatic vessel dysfunction or obstruction?", "Does the image reveal features of the cardiovascular, renal, or lymphatic systems that might be involved in abnormal fluid retention?", "Are there indications of fluid accumulation in loose connective tissue or areolar tissue?", "Can you observe any alterations in capillaries, venules, or veins that might contribute to fluid leakage?", "Is there evidence of disruption to anatomical barriers like capillary endothelium or basement membrane that could affect fluid movement?"], "contexual_behavior": [], "functions": ["Does the image show evidence of tissue swelling that could indicate increased interstitial pressure?", "Can you identify an area where excess accumulation of interstitial fluid might be present?", "Is there a region where tissue fluid balance appears disrupted, possibly due to reduced fluid reabsorption?", "Does the image display localized swelling that could be associated with increased vascular permeability?", "Can you see signs of impaired organ function that might result from altered tissue architecture or increased pressure?", "Is there visual evidence suggesting that nutrient or oxygen delivery to tissues could be compromised, such as compressed capillaries or increased diffusion distance?", "Does the image show features that might indicate overloading or obstruction of lymphatic vessels, suggesting hindered lymphatic drainage?", "Can you identify areas where wound healing appears delayed, possibly due to increased infection risk or disrupted tissue repair?", "Is there a region where cellular signaling could be altered, such as changes in tissue structure that might affect cytokine gradients?", "Does the image reveal signs of chronic inflammation or tissue damage that could facilitate fibrosis?", "Can you see indications that metabolic waste removal from tissues might be impaired, such as slowed interstitial fluid flow or compromised venous and lymphatic clearance?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a disruption in the integrity of a structure that could be part of the musculoskeletal system?", "Can you detect abnormalities in bones that are weight-bearing or appear osteoporotic?", "Is there evidence of a condition that might compromise mobility or structural support in the appendicular or axial skeleton?"], "contexual_behavior": [], "functions": ["Does the image suggest the influence of regulatory mechanisms, such as growth factors or cytokines, in the healing process?", "Can you identify a region where skeletal stability appears disrupted, possibly affecting weight bearing or mobility?", "Is there visual evidence of cellular activity, such as bone matrix synthesis or resorption, contributing to restoration of bone integrity?"]}}, "typical tuberculous exudate": {"yes_questions": {"contexual_properties": ["Does the image show an area where exudate appears thicker, possibly indicating chronic inflammation or progression of caseation?", "Can you identify a region where the exudate has changed color, suggesting cellular breakdown or a secondary infection?", "Is there evidence of caseous material, which could result from extensive tissue necrosis and immune cell infiltration?", "Does the image display an accumulation of exudate that might indicate active infection and ongoing exudation?", "Can you see a reduction in exudate volume, possibly reflecting resolution of inflammation or development of fibrosis?", "Is there a region where the exudate appears more cellular, which could be due to acute inflammation or granuloma formation?", "Does the exudate appear more protein-rich, potentially as a result of increased vascular permeability or plasma protein leakage?", "Can you identify areas where the exudate looks more fibrinous, suggesting fibrinogen leakage and fibrin formation?", "Is there evidence of increased lymphocyte presence within the exudate, indicating an adaptive immune response to infection?", "Does the image show purulent features in the exudate, which might occur with secondary bacterial infection?", "Can you see signs of calcification within the exudate, possibly reflecting healing or chronic granulomatous inflammation?", "Is there a region where the exudate appears less viscous, which could be due to enzymatic degradation or liquefaction necrosis?", "Does the exudate contain more necrotic material, suggesting intensified tissue destruction by immune cells?", "Can you observe changes in the exudate that might reflect alterations in pH due to metabolic activity of immune cells or bacteria?", "Is there visible debris within the exudate, possibly resulting from cellular lysis and tissue breakdown?", "Does the exudate appear more granular, which could indicate advancing caseous necrosis and debris accumulation?", "Can you identify an area with increased acid-fast bacilli, suggesting active proliferation of mycobacteria?", "Is there evidence that the exudate has become more organized, possibly due to fibrosis and encapsulation in a chronic lesion?", "Does the exudate appear less cellular, which might indicate subsiding inflammation or clearance of necrotic tissue?", "Can you observe any changes in the protein characteristics of the exudate, possibly reflecting different phases of inflammation or immune response?"], "properties": ["Is there a fluid in the image that appears thick and cloudy?", "Can you identify a substance with a straw-colored or pale yellow appearance?", "Does the image show a viscous or caseous material?", "Is there evidence of a fluid that might have a high protein concentration?", "Can you see a sample that could be associated with low glucose levels?", "Is there a fluid that appears to have an elevated cell count, possibly between 500 and 5000 cells per microliter?", "Does the image suggest the presence of lymphocytes, macrophages, or multinucleated giant cells within a fluid sample?", "Is there a fluid that might be acidic, with a pH below 7.2?", "Can you identify a sample that could have a high specific gravity, above 1.018?", "Does the image show a fluid that might have elevated lactate dehydrogenase (LDH) levels?", "Is there evidence of increased cholesterol concentration, possibly above 45 mg/dL, in any of the fluids present?", "Can you see a sample with high fibrin content, potentially showing signs of clot formation?", "Is there a fluid with a moderate to large volume, as might be seen in pleural or peritoneal involvement?", "Does the image show a fluid that appears odorless or has no offensive odor?", "Is there a turbid or cloudy fluid present, rather than a clear one?"], "relational": ["Does the image show evidence of inflamed tissue undergoing a granulomatous response?", "Can you identify areas where macrophages, lymphocytes, or multinucleated giant cells are present?", "Is there a visible accumulation of material within or around granulomas?", "Does the image contain structures located in the lungs, lymph nodes, or serous membranes that appear abnormal?", "Can you see any features consistent with granulomatous tissue?", "Is there evidence of interaction with alveolar walls, pleural surfaces, or lymphatic vessels?", "Does the image show abnormal material within the pleural, peritoneal, or pericardial cavity?", "Are there larger pathological structures such as caseating nodules or tuberculous granulomas present?", "Can you identify immune cells like T lymphocytes, macrophages, or epithelioid cells within an abnormal accumulation?", "Is there a region showing caseous necrosis or tissue destruction associated with an exudative process?"], "contexual_behavior": ["Does the image show an area where immune cell activity appears reduced, possibly indicating immunosuppression or advanced disease?", "Can you identify a region with increased protein content, which might suggest active infection and inflammation?", "Is there evidence of ineffective containment of Mycobacterium tuberculosis, as might occur in immunodeficient or HIV-infected individuals?", "Does the image reveal impaired granuloma formation, potentially due to severe immunosuppression or genetic immune defects?", "Can you see increased fibrin deposition, which could be a sign of chronic disease and persistent inflammation?", "Is there a visible reduction in antimicrobial activity, as might be expected in immunocompromised states or under corticosteroid therapy?", "Does the image suggest altered cellular composition, possibly due to co-infection with other pathogens?", "Can you observe increased caseation or areas of caseous necrosis, which are associated with advanced tuberculosis?", "Is there evidence that infection localization has been lost, perhaps due to granuloma disruption or immune failure?", "Does the image show increased macrophage recruitment, indicating acute inflammation or early infection?", "Can you identify reduced lymphocyte infiltration, which may be present in late-stage disease or immune exhaustion?", "Is there a failure to restrict bacterial spread, as might occur under steroid therapy or immunosuppression?", "Does the image suggest adaptation to different tissue environments, as seen in extrapulmonary tuberculosis?", "Can you observe increased viscosity or density, potentially due to chronic infection and protein accumulation?", "Is there a visible decrease in defensive function, possibly related to malnutrition or immune deficiency?"], "functions": ["Does the image show evidence of a process that localizes infection and promotes immune cell accumulation?", "Can you identify an area where granuloma formation appears to be occurring?", "Is there a region where macrophages and lymphocytes seem to be concentrated at a site of infection?", "Does the image display features suggesting the aggregation of immune cells to form a matrix that walls off bacteria?", "Can you see a physical or immunological barrier that might be restricting the spread of Mycobacterium tuberculosis?", "Is there visible tissue inflammation characterized by immune cell infiltration and the presence of pro-inflammatory mediators?", "Does the image show signs of chemotactic activity, such as the recruitment of macrophages, neutrophils, or lymphocytes to a specific area?", "Can you identify regions where tissue destruction is evident, possibly due to the release of lytic enzymes or oxidative stress from immune cells?", "Is there evidence of lesion progression, such as caseation, fibrosis, or liquefaction within granulomas?", "Does the image display areas of caseous necrosis, indicated by the accumulation of cellular debris and lipid-rich material?", "Can you see features that suggest the infection is being contained locally, or alternatively, signs that liquefaction may be facilitating dissemination through airways or lymphatics?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure with an estimated volume of 8 to 12 cubic centimeters?", "Is there a sloping, concave bone visible in the cranial base?", "Does the image contain a structure forming an angle of about 120 to 135 degrees with the skull base?"], "relational": ["Is there an area associated with the posterior cranial fossa?", "Is there a structure closely related to the pons or medulla oblongata?", "Can you see a structure that is centrally located at the base of the skull?"], "contexual_behavior": ["Is there visual evidence of bone destruction or displacement of tissues near neurovascular structures that could suggest tumor invasion?", "Is there evidence of bone swelling or erosion at the cranial base that might be due to inflammatory conditions such as osteitis or granulomatous disease?", "Can you identify any signs of instability or fracture at the base of the skull that might result from trauma?"], "functions": ["Does the image show a sloping bony surface that supports the brainstem?", "Is there a bony platform that prevents downward displacement of the brainstem?", "Can you see a structure that connects the sphenoid and occipital bones, reinforcing the central skull base?"]}}, "mucoepidermoid carcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a malignant tumor arising from the salivary gland system?", "Is there evidence of a mass affecting epithelial or glandular tissues?", "Can you identify a lesion located in or near the parotid or submandibular gland?", "Does the image contain a tumor involving the palate or other minor salivary gland sites?", "Is there a structure that could be part of the digestive or respiratory system and appears abnormal?", "Can you see a mass composed of different cell types such as mucous, squamous, or intermediate cells?", "Is there a lesion surrounded by connective tissue, nerves, or blood vessels?", "Does the abnormality appear to originate from a major salivary gland such as the parotid, submandibular, or sublingual gland?", "Can you identify anatomical boundaries such as a gland capsule, adjacent soft tissue, or bone around a suspicious mass?", "Is there involvement of regional lymphatic structures like cervical or submandibular lymph nodes near the lesion?", "Does the mass appear to invade neighboring tissues such as muscle, skin, or bone?", "Is there a tumor whose extent is defined by the gland capsule or adjacent soft tissue?"], "contexual_behavior": [], "functions": ["Does the image show a lesion with features of uncontrolled growth or local invasion into surrounding tissues?", "Is there evidence of a mass infiltrating adjacent structures, suggesting matrix degradation or tissue infiltration?", "Can you identify an area where normal glandular organization appears disrupted or replaced by abnormal tissue?", "Does the image reveal a region where glandular secretion might be impaired or reduced?", "Is there a structure that could be associated with abnormal cell proliferation, such as increased cellular density or atypical mitotic figures?", "Can you see signs of immune cell recruitment or local inflammation around a suspicious lesion?", "Is there evidence of new blood vessel formation, possibly indicating angiogenesis within or near a mass?", "Does the image display architectural disruption or stromal remodeling in the affected area?", "Can you identify regions where the extracellular matrix appears modified or where stromal cells are recruited to a lesion?", "Is there a mass that appears resistant to cell death, as suggested by the presence of viable tumor cells in areas where apoptosis would be expected?", "Does the image suggest potential for metastasis, such as tumor cell detachment or invasion into vascular structures?", "Can you observe any changes in the composition or amount of glandular secretions in the vicinity of an abnormal growth?"]}, "no_questions": {"contexual_properties": ["Are there visible changes in mitochondrial size that might reflect mitochondrial dysfunction or metabolic stress?", "Is there evidence of disrupted membrane structure consistent with necrosis or severe membrane damage?", "Are there changes in cytoskeletal organization that could be related to cell migration or cytoskeletal disorders?"], "properties": ["Does the image display a range of gray shades that might correspond to 8-bit or 16-bit grayscale depth?", "Is it possible to estimate the number of bits used to represent each pixel in the image data?", "Is there any indication of the digital format used to store this image, such as TIFF, JPEG, or PNG?"], "relational": ["Can you identify features characteristic of macromolecular complexes?", "Is there evidence of epithelial cells, muscle tissue, or neurons being visualized?", "Is there detailed visualization of fine structural features or organelle organization?"], "contexual_behavior": ["Is there a loss of clarity in protein complexes that could be explained by beam-induced damage during imaging?", "Can you observe enhanced contrast in the image that might indicate the use of heavy metal staining techniques?", "Can you see improved distinction of membrane structures that would be consistent with cryo-fixation preserving native ultrastructure?"], "functions": ["Can you identify organelles or macromolecular complexes not typically visible with light microscopy?", "Does the image show the morphology or spatial organization of organelles, allowing for functional analysis?", "Is there evidence of cellular processes or subcellular features that indicate detailed study of cell biology?"]}}, "adenocarcinoma": {"yes_questions": {"contexual_properties": ["Does the image show a mass that appears larger, suggesting active cell division or tumor progression?", "Is there evidence of a lesion that has decreased in size, possibly indicating a response to therapy such as chemotherapy or surgical removal?", "Can you identify an area where the color of the tissue is altered, which might suggest hemorrhage, necrosis, or changes in blood supply?", "Is there a structure with increased visible blood vessels, consistent with angiogenesis or tumor growth under hypoxic conditions?", "Do you see regions within a mass that appear pale or necrotic, possibly due to insufficient blood supply and resulting cell death?", "Is there a firm or hardened area within the lesion, which could be due to increased fibrous tissue or desmoplastic reaction?", "Does the image show cells with abnormal shapes or sizes, suggesting increased cellular atypia or genetic instability?", "Can you identify areas with mucinous or secretory material, indicating glandular differentiation or a mucinous subtype?", "Is there a change in the growth pattern of a mass, such as loss of normal glandular structure or evidence of invasion into surrounding tissue?", "Do you see any calcified regions within the lesion, which may be due to dystrophic calcification in necrotic tumor tissue?", "Is there evidence that the degree of differentiation has changed, such as loss of glandular features or increased anaplasia?", "Can you observe features suggesting invasion beyond normal tissue boundaries, such as disruption of basement membranes or infiltration into adjacent structures?", "Are there cystic or fluid-filled components within the mass, possibly resulting from degeneration, necrosis, or mucin accumulation?", "Does the image reveal a high number of mitotic figures, indicating rapid cell proliferation or a high tumor grade?", "Is there distortion or disruption of normal glandular architecture, suggesting neoplastic invasion into the stroma?", "On imaging, does the lesion show increased metabolic activity, such as elevated glucose uptake on a PET scan?", "Can you detect changes in the density of the lesion on radiological scans, which might be due to necrosis, fibrosis, calcification, or cystic transformation?", "Is there evidence of ulceration or surface breakdown, possibly due to tumor invasion eroding the overlying mucosa or skin?", "Do you see areas of hemorrhage within the mass, which could result from fragile or invaded blood vessels?", "Is there any indication of elevated tumor marker production, such as secretory activity visible in the tissue or suggested by increased tumor burden?"], "properties": ["Does the image show a mass whose size could range from a few millimeters to several centimeters?", "Is there a structure present that might weigh anywhere from a few grams to several hundred grams depending on its size?", "Can you identify a lesion composed of round or oval cells arranged in glandular or acinar patterns?", "Is there a tissue area that appears whitish to tan, possibly with regions of hemorrhage or necrosis?", "Does the image contain a mass made up of malignant epithelial cells forming glands, along with stromal and inflammatory cells?", "Is there evidence of increased mitotic activity, such as 5 to 20 mitoses per 10 high-power fields, within a particular tissue?", "Can you see cells with a high nuclear-to-cytoplasmic ratio compared to normal glandular cells?", "Is there a region where glandular differentiation varies, ranging from well-formed glands to poorly differentiated structures?", "Does the image suggest a proliferation index (such as Ki-67) that could be between 20% and 80% in a particular area?", "Can you identify a tissue area that might be classified as low, intermediate, or high grade based on histological features?", "Is there evidence of increased mucin content, either within cells or in the extracellular space?", "Does the image show cells with variable DNA ploidy, such as aneuploid, diploid, or tetraploid patterns?", "Can you identify regions with 1 to 5 mitoses per high-power field, or possibly higher in more aggressive areas?", "Is there a structure that might exhibit elevated levels of tumor markers such as CEA compared to surrounding tissue?", "Does the tissue display increased vascular density, with numerous small blood vessels suggestive of angiogenesis?", "Can you see architectural patterns such as glandular, acinar, or papillary structures within the lesion?", "Is there evidence of moderate to marked cellular atypia, including pleomorphic nuclei and prominent nucleoli?", "Does the image show areas of necrosis, either focal or extensive, within a rapidly growing mass?", "Can you identify cells with eosinophilic or clear cytoplasm, possibly containing mucin vacuoles?", "Is there a population of cells with one or more prominent and enlarged nucleoli per cell?"], "relational": ["Does the image show a mass arising from glandular or mucosal tissue?", "Is there evidence of abnormal proliferation within glandular epithelium?", "Can you identify a lesion that appears to originate from epithelial or glandular cells?", "Is there a tumor located in an organ such as the lung, colon, pancreas, prostate, breast, or stomach?", "Does the image display a neoplastic growth in the thoracic, abdominal, or pelvic region?", "Can you see a mass that is adjacent to connective tissue, blood vessels, or lymphatic vessels?", "Is there a structure in proximity to regional lymph nodes or lymphatic capillaries?", "Does the image suggest involvement of the respiratory, digestive, endocrine, or reproductive system by a tumor?", "Can you identify a lesion with features of epithelial neoplasia?", "Is there visual evidence of a mass interacting with capillaries, arterioles, venules, or major blood vessels?", "Does the image show possible pathways for tumor spread, such as along lymphatic vessels, blood vessels, or serosal surfaces?", "Is there a mass that could be affecting neighboring organs?"], "contexual_behavior": ["Is there evidence of a malignant structure invading surrounding tissues, possibly indicating increased motility or changes associated with epithelial-mesenchymal transition?", "Can you identify features suggesting resistance to chemotherapy, such as the presence of cells with multidrug resistance characteristics or overexpression of efflux pumps?", "Does the image show a tumor with reduced secretion of markers, which might be associated with poor differentiation or response to therapy?", "Are there signs of altered metabolic activity, such as regions that might indicate adaptation to hypoxic conditions or increased glycolysis?", "Is there evidence of new blood vessel formation, possibly in response to low oxygen levels and secretion of pro-angiogenic factors like VEGF?", "Can you observe a decrease in cell proliferation that could be attributed to targeted therapy or inhibition of oncogenic signaling pathways?", "Does the image suggest an immune response against tumor cells, possibly due to immune checkpoint inhibition or activated immune cells?", "Are there visual cues of increased metastatic potential, such as tumor spread in the context of chronic inflammation or matrix remodeling?", "Can you detect changes in tumor growth rate that might be influenced by hormonal regulation, especially in hormone-sensitive tissues?", "Is there evidence of impaired apoptosis, such as abnormal cell survival patterns that could be linked to mutations in apoptotic regulators like p53?", "Do you see signs of increased secretion of growth factors in areas with abundant nutrients, supporting enhanced proliferation and survival?", "Is there a reduction in invasive behavior or tumor spread that could be associated with recent radiation therapy and DNA damage?", "Are there indications of extracellular matrix remodeling, such as increased proteolytic activity or upregulation of matrix metalloproteinases?", "Does the image suggest reduced tumor activity or regression in response to anti-angiogenic therapy targeting blood vessel formation?", "Can you identify features of immune evasion, possibly due to immunosuppression or weakened host immune responses?", "Are there signs of metabolic adaptation, such as reliance on alternative substrates like glutamine or fatty acids during glucose deprivation?", "Is there evidence of increased production of pro-inflammatory cytokines, possibly due to interactions with stromal or immune cells in the tumor microenvironment?", "Do you observe a decrease in metastatic spread following surgical removal of a primary tumor, suggesting loss of pro-metastatic factors?", "Are there features indicating enhanced drug efflux activity, such as overexpression of ATP-binding cassette transporters in multidrug-resistant cells?", "Can you detect reduced proliferation or signs of quiescence and autophagy in response to nutrient starvation within the tumor?"], "functions": ["Does the image show a region where cells appear to be proliferating uncontrollably or invading surrounding tissue?", "Is there evidence of structures that could indicate the breakdown of the basement membrane or extracellular matrix?", "Can you identify an area where normal glandular architecture is disrupted or replaced by abnormal cells?", "Does the image reveal new blood vessel formation that might suggest neovascularization?", "Is there a region where immune cells seem absent or ineffective, possibly due to immune evasion mechanisms?", "Can you see signs that suggest cells have entered blood or lymphatic vessels, indicating possible spread to distant sites?", "Is there visual evidence of abnormal cellular signaling, such as increased cell density or loss of normal tissue organization?", "Does the image show disruption of tissue homeostasis, such as abnormal cell turnover or changes in the local microenvironment?", "Are there areas where cells appear resistant to programmed cell death, such as clusters of densely packed abnormal cells?", "Can you observe features that suggest dysregulation of the cell cycle, like increased mitotic figures or abnormal growth patterns?", "Is there evidence of extracellular matrix remodeling, such as irregular tissue boundaries or degraded matrix components?", "Does the image show signs of local inflammation, such as immune cell infiltration or increased cellularity?", "Are there indications of microenvironmental changes, like regions of hypoxia, altered pH, or activated stromal cells?", "Can you identify areas where cells might be increasing their glucose uptake or displaying altered metabolic activity?", "Does the image reveal sustained proliferative signaling, such as continuous growth without evidence of normal growth suppression?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show spherical or ovoid structures within the nucleus that are between 1 and 5 micrometers in diameter?", "Can you see nuclear regions that might be composed of nucleophosmin, fibrillarin, or nucleolin?", "Can you identify one to several basophilic inclusions per nucleus when stained with hematoxylin and eosin?"], "relational": ["Is there evidence of interaction between a subnuclear structure and the nuclear envelope or nucleoplasm?", "Does the image contain a substructure within the nucleus that is associated with the endoplasmic reticulum?", "Can you see components such as a fibrillar center, dense fibrillar component, or granular component within a nuclear structure?"], "contexual_behavior": ["Does the image show a feature that increases its activity during embryonic development to support rapid cell division?", "Is there a structure that could decrease rRNA processing in conditions of nutrient deprivation as a resource conservation mechanism?", "Is there a structure that fails to support protein synthesis in neurodegenerative diseases due to disrupted nucleolar integrity?"], "functions": ["Does the image contain a structure that regulates gene expression by controlling ribosome availability?", "Can you see an object that supports cell growth by increasing ribosome biogenesis during cell proliferation?", "Can you identify a site where small nucleolar ribonucleoproteins are assembled and matured?"]}}, "excellent photo typical adenocarcinoma": {"yes_questions": {"contexual_properties": ["Does the image show a lesion that appears to have increased in size, suggesting active cell proliferation?", "Is there evidence of a mass that has decreased in size, possibly indicating a response to treatment such as chemotherapy or surgical removal?", "Can you identify a region where the color of the tissue has changed, which might reflect hemorrhage, necrosis, or altered blood supply?", "Is there a structure with prominent blood vessels, suggesting increased vascularization due to angiogenesis?", "Do you see areas of tissue death within the mass, possibly resulting from rapid growth outpacing its blood supply?", "Is there evidence of increased cellular atypia or abnormal cell features, which could indicate a higher histological grade or genetic changes?", "Can you observe regions with a mucinous appearance, suggesting increased mucin production by tumor cells?", "Are there areas with a high number of mitotic figures, indicating accelerated cell division?", "Does the image show calcified regions within the mass, possibly due to dystrophic mineralization in necrotic areas?", "Is there evidence of tissue infiltration into surrounding structures, suggesting an invasive or metastatic process?", "Can you identify changes in glandular patterns, such as loss or alteration, which may be associated with tumor progression or therapy response?", "Does the mass appear heterogeneous in texture, with regions of necrosis, fibrosis, or variable cellularity?", "Is there visible nuclear pleomorphism, such as variation in nuclear size and shape, indicating a higher grade or genetic instability?", "Do you see fibrotic areas within or around the lesion, possibly due to chronic inflammation or a desmoplastic reaction?", "Is there evidence of increased tumor marker expression, such as areas with high cellularity or secretory activity?", "Can you identify cystic spaces within the mass, which might result from degeneration or mucin accumulation?", "Does the lesion show loss of glandular differentiation, appearing more poorly differentiated or undifferentiated?", "Are there hemorrhagic regions within the mass, possibly due to rupture of fragile vessels or rapid growth?", "Is there variation in cell density across the lesion, which could be related to tumor progression, necrosis, or stromal reaction?", "Does the mass appear more solid, with loss of glandular structures and increased cellularity?"], "properties": ["Does the image show cells with round to oval nuclei and moderate amounts of cytoplasm forming well-defined glandular structures?", "Can you identify tumor cells that measure between 15 and 25 micrometers in diameter?", "Is there evidence of a moderate nuclear-to-cytoplasmic ratio in the cells present?", "Are there well-formed, round to oval glands with clear lumina visible in the tissue?", "Does the sample display a low mitotic rate, with few mitotic figures per high-power field?", "Under H&E staining, do the nuclei appear basophilic and the cytoplasm eosinophilic with distinct glandular outlines?", "Is the cytological appearance of the tissue uniform, with minimal pleomorphism and regular nuclear contours?", "Can you observe mild to moderate cellular atypia in the cells present?", "Are moderate amounts of intracellular mucin visible within the tumor cells?", "Does the architectural pattern predominantly show acinar or tubular arrangements with orderly gland formation?", "Are the nuclei of the cells approximately 8 to 12 micrometers in size?", "Do the nuclei display finely granular chromatin?", "Is the cytoplasm moderate in amount and lightly eosinophilic in appearance?", "Does more than 75% of the tumor area demonstrate glandular differentiation?", "Is the overall tissue color pink to light purple under the microscope due to H&E staining?", "Is the degree of pleomorphism in the cells low to moderate?", "Are the cells arranged in well-organized glandular or acinar patterns?", "Is necrosis minimal or absent in the tissue sample?", "Do most cells contain one to two small, inconspicuous nucleoli?", "Is cytoplasmic granularity minimal, with smooth cytoplasm predominating in the cells?"], "relational": ["Does the image show a lesion associated with either the digestive or respiratory system?", "Can you identify a region involving glandular epithelium or submucosa?", "Is there evidence of abnormal tissue in organs such as the lung, colon, stomach, or pancreas?", "Does the image display cells with features of malignant glandular epithelial cells?", "Can you see stromal or inflammatory cells within or around a suspicious lesion?", "Is there a structure surrounded by a basement membrane or adjacent to normal parenchyma?", "Are blood vessels visible near or within the abnormal area?", "Does the image contain a lesion that could arise from glandular epithelium?", "Can you identify anatomical boundaries such as tumor margins or signs of invasion depth?", "Is there evidence of encapsulation around a suspicious mass?", "Are regional lymph nodes or lymphatic vessels present near the affected area?", "Can you see capillaries, arterioles, venules, or new blood vessels associated with the lesion?", "Does the image show a mass in an organ like the prostate, lung, colon, stomach, or pancreas?"], "contexual_behavior": ["Is there evidence of a structure that increases its proliferative activity under low-oxygen conditions?", "Can you identify a region that shows reduced cell death in response to chemotherapy?", "Does the image display features suggestive of increased invasive behavior in the context of chronic inflammation?", "Is there a structure that appears to have adapted to nutrient deprivation by reducing its metabolic rate?", "Can you see signs of altered blood vessel formation in response to anti-angiogenic therapy?", "Is there evidence of resistance to immune cell-mediated destruction, such as overexpression of immune checkpoint molecules?", "Does the image show impaired cellular differentiation that could be linked to genetic mutations?", "Can you identify a region with upregulated growth factor signaling, such as increased receptor expression?", "Is there a structure that appears less responsive to hormonal regulation, possibly due to loss of hormone receptor expression?", "Does the image suggest increased metastatic potential following exposure to radiation, such as features of aggressive clonal selection?", "Can you observe alterations in the secretion of extracellular matrix components that might facilitate tissue invasion?", "Is there evidence of decreased sensitivity to targeted therapies, potentially due to resistance mutations or alternative signaling pathways?", "Can you identify enhanced glycolytic activity in areas with low oxygen, indicating a shift toward anaerobic metabolism?", "Does the image show failure of cell cycle arrest in response to DNA damage, possibly due to checkpoint protein dysfunction?", "Is there evidence of increased production of immunosuppressive cytokines within the tumor microenvironment?"], "functions": ["Does the image show a region with abnormal gland-like structures formed by uncontrolled epithelial cell growth?", "Is there evidence of tissue invasion or disruption of normal tissue architecture in the image?", "Can you identify areas where glandular differentiation appears abnormal or where healthy glandular tissue is replaced?", "Does the image reveal features suggestive of increased cell proliferation or loss of growth control?", "Are there visual cues indicating secretory dysfunction or impairment of normal glandular function?", "Can you observe signs of angiogenesis, such as the presence of newly formed blood vessels?", "Is there evidence of matrix degradation or expression of proteolytic enzymes affecting the extracellular matrix?", "Do you see indications of altered cell adhesion or loss of normal cellular cohesion?", "Are there features consistent with local tissue invasion or possible entry into blood or lymphatic vessels?", "Does the image suggest structural distortion or replacement of normal tissue that could impair organ function?", "Can you identify regions where metabolic changes, such as increased glycolysis, might be inferred from cellular morphology?", "Is there evidence of apoptosis resistance, such as densely packed cells with minimal signs of cell death?", "Are there visual signs that could indicate immune evasion, such as lack of immune cell infiltration in abnormal areas?", "Does the image show disruption of normal signaling pathways, as suggested by abnormal patterns of growth, differentiation, or apoptosis?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is the background color predominantly white, black, or light gray?", "Can you estimate the aspect ratio of the image, such as whether it is closer to 4:3 or 16:9?", "Is it possible to deduce the number of bits used for each pixel based on the image's color richness or grayscale levels?"], "relational": ["Are there visual cues suggesting the use of stains like hematoxylin and eosin, PAS, or immunohistochemistry?", "Does the image appear to be derived from a tissue sample, biopsy, or organ section?", "Does the image reveal details that might belong to the nervous, digestive, respiratory, or cardiovascular systems?"], "contexual_behavior": ["Does the image show evidence of inadequate sample preparation, such as loss of cellular detail or the presence of artifacts?", "Can you observe the effects of histochemical stains, immunohistochemistry, or fluorescent labeling in the image?", "Can you detect reduced staining intensity or diminished enzyme activity that might suggest hypoxic conditions?"], "functions": ["Does the image allow for the visualization of cellular processes such as cell division or signaling at high resolution?", "Is there enough morphological detail in the image to classify microorganisms based on their distinguishing traits?", "Can you identify signs of malignancy, inflammation, or other pathological changes that would be relevant for biopsy evaluation?"]}}, "colon": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify regions such as the ascending, transverse, descending, or sigmoid segments within the image?", "Is there a structure that appears adjacent to the small intestine or rectum?", "Can you see any anatomical features located near the kidneys or bladder?", "Does the image contain vessels that could correspond to the superior or inferior mesenteric arteries supplying a digestive organ?", "Is there evidence of innervation by the enteric nervous system or by fibers from the vagus or pelvic splanchnic nerves in any visible structure?", "Can you identify a region that is continuous with the rectum at its terminal end?", "Is there a visible junction where the ileum meets a larger tubular structure, possibly involving the ileocecal valve?", "Does the image show a wall composed of multiple layers such as mucosa, submucosa, muscularis propria, and serosa?", "Are there lymphatic structures present, such as mesenteric or colic lymph nodes, associated with a tubular digestive organ?", "Can you identify anatomical boundaries such as the ileocecal junction or rectosigmoid junction in the image?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for absorbing water from digested food?", "Can you identify an area involved in regulating electrolyte levels, such as sodium and chloride absorption?", "Is there a region where undigested carbohydrates might be fermented by anaerobic bacteria?", "Does the image contain a structure that compacts waste material and stores it until elimination?", "Can you see evidence of an environment that supports the proliferation of beneficial gut microbiota?", "Is there a visible area where vitamins like vitamin K and B vitamins could be absorbed after being synthesized by resident bacteria?", "Does the image show a structure that propels fecal matter toward the rectum for excretion?", "Can you identify a region involved in maintaining fluid balance through water and electrolyte reabsorption?", "Is there a structure present that contributes to immune defense via gut-associated lymphoid tissue or antimicrobial peptide production?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you deduce from the staining pattern whether the antibodies used could have a molecular weight in the range of 150 to 160 kDa?", "Is there evidence of a staining protocol that could achieve sensitivity greater than 90%?", "Does the image suggest that the staining reagents might have a shelf life of 6 to 24 months depending on storage conditions?"], "relational": ["Does the image contain cells that could be epithelial cells, lymphocytes, or neurons?", "Can you see a tissue section from regions like lymph nodes, brain, breast, or prostate?", "Is there a sample that appears to be prepared for detecting specific antigens?"], "contexual_behavior": [], "functions": ["Can you identify a method in the image that highlights the presence of particular proteins by producing a visible signal?", "Can you observe abnormal protein expression patterns that might aid in pathological diagnosis?", "Does the image display localized color changes that correspond to the distribution of specific antigens?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Are there visible extracellular matrix components such as collagen or fibronectin present in the tissue?", "Is there evidence of cell types like fibroblasts or mesenchymal stem cells within the tissue?", "Is there a visible microenvironment, such as a stem cell niche or perivascular region, that could support the proliferation of certain stromal cells?"], "contexual_behavior": [], "functions": ["Is there any indication of interactions between stromal and cancer cells that could promote tumor progression or immune evasion?", "Is there evidence of cell populations involved in tissue remodeling or regeneration?", "Are there cells that seem to be supporting neighboring cell types through structural scaffolding or secreted factors?"]}}, "typical adenocarcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion originating from glandular or secretory epithelium?", "Is there evidence of abnormal tissue in organs such as the lung, colon, breast, pancreas, prostate, or stomach?", "Can you identify a mass composed of malignant glandular epithelial cells?", "Does the image reveal the presence of stromal fibroblasts or inflammatory cells within a suspicious area?", "Is there a structure located within the respiratory, digestive, reproductive, or endocrine systems that appears abnormal?", "Can you see a lesion situated in the thoracic cavity, abdominal cavity, or pelvic region?", "Is there visual evidence of malignant transformation affecting glandular epithelium?", "Does the image show a mass invading adjacent organs, lymphatic vessels, blood vessels, or muscle tissue?", "Are tumor margins, an invasion front, or encapsulating tissue visible around an abnormal structure?", "Can you identify involvement of regional or distant lymph nodes, or lymphatic capillaries near a suspicious lesion?", "Is there a mass adjacent to parenchyma, connective tissue, or blood vessels?"], "contexual_behavior": [], "functions": ["Does the image show a structure characterized by uncontrolled cell proliferation?", "Is there evidence of local invasion into adjacent tissues by a mass in the image?", "Can you identify an area where normal tissue architecture is disrupted or replaced?", "Does the image reveal irregular glandular patterns or architectural abnormalities?", "Is there a region that suggests new blood vessel formation, possibly due to VEGF secretion?", "Can you see signs of immune cell recruitment or local inflammation near a suspicious lesion?", "Is there visual evidence of tissue infiltration or extracellular matrix degradation by a lesion?", "Does the image show features that might indicate metastatic spread to distant sites?", "Is there a mass that appears to interact with surrounding stromal cells or modify the microenvironment?", "Can you identify regions where fibroblast activation or increased matrix metalloproteinase activity might be occurring?", "Is there a structure that could be resisting programmed cell death, as suggested by persistent abnormal cell clusters?", "Does the image show signs of sustained mitogenic signaling, such as continuous abnormal cell growth?", "Can you see evidence of paracrine signaling or remodeling of the extracellular matrix around a lesion?", "Is there a mass that appears to impair normal organ function by replacing healthy tissue?", "Does the image suggest the presence of anti-apoptotic activity within a suspicious area?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a region with a width of about 2 to 3 centimeters at its broadest point?", "Does the image show a bone whose mineral content is primarily hydroxyapatite and calcium phosphate?", "Does the image show a bony area with a thickness of roughly 1 to 1.5 centimeters?"], "relational": ["Does the image show proximity to vascular structures such as the basilar artery or inferior petrosal sinus?", "Can you see a region that forms the posterior part of the sphenoid bone and the anterior part of the occipital bone, articulating with both?", "Can you identify a location near the hypoglossal canal or jugular foramen?"], "contexual_behavior": ["Can you observe deformation or displacement of a cranial base structure that could be related to increased intracranial pressure?", "Can you identify any signs of instability or fracture at the base of the skull that might result from trauma?", "Is there evidence of bone swelling or erosion at the cranial base that might be due to inflammatory conditions such as osteitis or granulomatous disease?"], "functions": ["Is there a midline element that helps maintain alignment between anterior and posterior cranial structures?", "Can you see a structure that connects the sphenoid and occipital bones, reinforcing the central skull base?", "Can you identify a structure that separates the posterior cranial fossa from the upper cervical spinal canal, thereby demarcating neural compartments?"]}}, "serosa": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a tissue layer in the image that appears glistening, pale, or translucent white?", "Can you identify a structure with a smooth and slippery surface texture?", "Does the image show a thin layer, approximately 20 to 100 micrometers thick, covering an organ?", "Is there evidence of a tissue composed of simple squamous cells supported by connective tissue?", "Can you see a region that might contain mesothelial cells or fibroblasts?", "Is there a layer that could have a high water content, around 70\u201380% by weight?", "Does the image show a structure that might contain moderate amounts of type I and III collagen fibers?", "Can you identify a tissue with low to moderate elastic fiber content, suggesting limited elasticity?", "Is there a surface that could potentially cover several hundred square centimeters, depending on the organ?", "Does the image include a layer likely to have a neutral pH, around 7.0 to 7.4?", "Can you see a structure that might allow the passage of small molecules and fluids?", "Is there a tissue with low lipid content, mainly present in cell membranes?", "Does the image show a layer with moderate protein content, possibly containing structural and functional proteins?", "Can you identify a tissue whose density is similar to other soft tissues, about 1.05 g/cm\u00b3?", "Is there a region that would be expected to match core body temperature, approximately 37\u00b0C?"], "relational": ["Does the image show an organ from the digestive or reproductive system that is lined by a thin outer membrane?", "Can you identify a structure that forms the outermost layer of the stomach, small intestine, large intestine, or uterus?", "Is there a visible layer composed of mesothelium and underlying connective tissue on any organ in the image?", "Does the image display a boundary separating an internal organ from a cavity such as the peritoneal cavity?", "Can you see a membrane that is continuous with the peritoneum?", "Is there a structure in the image that covers intestinal loops, the stomach, or the uterus?", "Does the image contain a membrane similar in appearance to the pericardium or pleura?", "Can you identify a layer present on the stomach, jejunum, ileum, transverse colon, or sigmoid colon?", "Is there a thin tissue layer supported by subserosa or loose connective tissue visible in the image?", "Can you see a membrane adjacent to the muscularis externa or subserosa in any organ present?"], "contexual_behavior": ["Does the image show a structure whose protective barrier function might be reduced during inflammation or infection?", "Is there evidence of increased fluid secretion in response to an acute inflammatory process?", "Can you identify a surface where adhesion formation could occur after surgery if healing is impaired?", "Does the image reveal a structure that may lose its lubricating ability in the presence of fibrosis or disease?", "Is there a region where increased permeability and immune cell infiltration might be seen during infection?", "Can you observe signs of impaired healing after injury, such as persistent inflammation or chronic tissue changes?", "Is there a surface that could display heightened immune activity during peritonitis, such as immune cell recruitment or inflammation?", "Does the image suggest a loss of anti-friction properties due to thickening, inflammation, or reduced serous fluid?", "Is there evidence of a barrier breach that could allow bacterial invasion following trauma, infection, or surgical intervention?", "Can you see features that might indicate cellular transformation or altered permeability in response to malignancy?", "Is there an accumulation of excess fluid that could be associated with heart or lung failure due to impaired fluid resorption?", "Does the image show loss of normal tissue separation, possibly due to fibrin deposition and exudate accumulation during inflammation?", "Can you identify increased cytokine production or inflammatory response following trauma in the depicted tissues?", "Is there a sign of impaired serous membrane repair in the context of chronic disease, malnutrition, or immunosuppression?", "Does the image suggest functional changes or chronic inflammation that could be associated with autoimmune disorders affecting serous membranes?"], "functions": ["Is there a thin membrane visible that provides a protective covering for internal organs?", "Can you identify a structure that acts as a physical barrier against mechanical injury or infection?", "Does the image show a surface that could reduce friction between organs by producing a lubricating fluid?", "Is there evidence of a slippery interface that would facilitate smooth movement of organs within a body cavity?", "Can you see a membrane that might be composed of specialized mesothelial cells responsible for secreting serous fluid?", "Is there a structure present that could help contain infections by limiting the spread of pathogens within a body cavity?", "Does the image include a membrane that might support tissue repair by providing a scaffold for cell migration?", "Can you identify a feature that maintains organ stability or prevents displacement within the cavity?", "Is there a membrane visible that separates different body cavities, such as the peritoneum, pleura, or pericardium?", "Does the image show a structure that could participate in immune defense by housing immune cells within a body cavity?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure adjacent to the uterus or fallopian tubes?", "Can you identify structures such as ovarian follicles or corpus luteum?", "Can you identify an object located within the pelvic cavity or lower abdomen?"], "contexual_behavior": [], "functions": ["Is there an organ that provides the microenvironment necessary for folliculogenesis?", "Does the image contain an organ that synthesizes hormones such as estrogen and progesterone?", "Does the image show a region where progesterone is produced, particularly after ovulation?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show a lesion ranging from a few millimeters to several centimeters in diameter?", "Does the image suggest the presence of a mass with possible MED12 mutation or HMGA2 rearrangement?", "Is there a structure with a water content estimated at 60\u201370% by weight?"], "relational": ["Can you identify a lesion embedded in the cervix?", "Is there a structure located within the cervical region of the uterus?", "Does the image show a mass associated with the female reproductive system?"], "contexual_behavior": [], "functions": ["Is there a visible lesion that could cause pelvic pain or a sensation of pressure by compressing nearby tissues?", "Does the image reveal any weakening of pelvic support structures that could contribute to pelvic organ prolapse?", "Is there a visible abnormality that could increase susceptibility to infection or inflammation by disrupting normal cervical or uterine barriers?"]}}}
[ { "answer": "typical infiltrating adenocarcinoma", "extracted_concepts": [ "typical infiltrating adenocarcinoma" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "typical infiltrating adenocarcinoma" ], "question": "does this image show typical infiltrating adenocarcinoma?" }, { "answer": "no", "extracted_concepts": [ "retroperitoneal", "adenocarcinoma", "retroperitoneal leiomyosarcoma" ], "question": "does retroperitoneal leiomyosarcoma show typical infiltrating adenocarcinoma?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "adrenal" ], "question": "is adrenal present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "colon" ], "question": "is colon present?" }, { "answer": "no", "extracted_concepts": [ "coronary artery anomalous origin left from pulmonary artery", "pulmonary artery", "coronary artery" ], "question": "is coronary artery anomalous origin left from pulmonary artery present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" } ]	["adrenal", "pulmonary artery", "retroperitoneal", "retroperitoneal leiomyosarcoma", "adenocarcinoma", "typical infiltrating adenocarcinoma", "colon", "gastrointestinal", "coronary artery anomalous origin left from pulmonary artery", "gastrointestinal system", "coronary artery"]	{"adrenal": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a triangular or crescent shape?", "Is there an object present that typically measures between 4 and 6 centimeters in length and 2 to 3 centimeters in width?", "Can you identify a structure that might weigh about 4 to 6 grams in an adult?", "Is there a yellowish-brown colored structure visible?", "Does the image contain a region where the outer layer is about 1.5 to 2.5 millimeters thick?", "Can you see an area with an inner layer approximately 0.5 to 1 millimeter thick?", "Is there a structure that could contain specialized cells such as chromaffin cells or those from the zona glomerulosa, fasciculata, or reticularis?", "Can you identify an object that is likely involved in the production of hormones like cortisol, aldosterone, adrenaline, or noradrenaline?", "Is there a structure that might have a relatively high cholesterol content, around 10 to 15 milligrams per gram of tissue?", "Does the image show an object that could have a water content of about 70 to 75 percent by weight?", "Can you see a structure whose tissue pH might be between 7.2 and 7.4?", "Is there an object with an estimated density of approximately 1.03 grams per cubic centimeter?", "Does the image contain a structure where lipids make up about 10 to 15 percent of its wet weight?", "Can you identify an object that may contain structural proteins, steroidogenic enzymes, or chromogranins?", "Is there a structure that appears firm but slightly friable in texture?", "Can you see an object that might contain physiologic amounts of sodium, potassium, calcium, and magnesium?", "Is there a structure with an estimated volume of about 4 to 5 milliliters?", "Does the image show an object with a blood flow rate of approximately 5 to 10 milliliters per minute per gram of tissue?"], "relational": ["Does the image show a structure that is part of the endocrine system?", "Can you identify an organ located superior to and adjacent to the kidneys?", "Is there a structure found in the retroperitoneal space of the upper abdomen?", "Does the image contain an object situated near the liver or diaphragm?", "Can you see a structure supported by renal fascia or surrounded by perirenal fat?", "Is there evidence of a gland receiving blood from the superior, middle, or inferior suprarenal arteries?", "Does the image show an organ composed of a cortex and a medulla?", "Can you identify tissue types such as glandular epithelium or chromaffin tissue within a structure?", "Is there a structure innervated by branches of the celiac plexus or splanchnic nerves?", "Can you see lymphatic vessels or nodes, such as lumbar lymph nodes, associated with a glandular structure in the upper abdomen?"], "contexual_behavior": [], "functions": ["Is there a structure present that is responsible for secreting hormones involved in the body's stress response?", "Can you identify an object that releases substances such as cortisol and adrenaline to help the body prepare for immediate action?", "Does the image show a structure that produces hormones like aldosterone and catecholamines?", "Is there an anatomical feature that influences blood pressure by affecting sodium and water retention in the kidneys?", "Can you see something that contributes to glucose metabolism and fat breakdown through hormone release?", "Is there a structure that helps regulate salt and water balance by controlling sodium reabsorption and potassium excretion?", "Does the image contain an object whose secretions suppress inflammation and modulate immune cell activity?", "Can you identify a feature that mobilizes energy stores and increases alertness during stressful situations?", "Is there a structure involved in the fight-or-flight response by increasing heart rate and directing blood flow to muscles?", "Does the image show an object that regulates blood sugar by stimulating gluconeogenesis and inhibiting insulin action?", "Is there a structure that produces precursors to sex hormones, contributing to sexual development and function?", "Can you see something that helps the body adapt to physical or emotional stress by adjusting metabolism, cardiovascular function, and immune activity?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a lesion affecting organs such as the liver, thyroid, lung, breast, or skin?", "Is there a mass supported by fibrous stroma, blood vessels, or connective tissue visible in the image?", "Is there an area composed of neoplastic, stromal, or inflammatory cells visible?"], "contexual_behavior": [], "functions": ["Does the image include a structure that might be activating oncogenic signaling or inhibiting tumor suppressor pathways?", "Is there a structure that appears to compress, infiltrate, or displace nearby tissues?", "Is there evidence of uncontrolled cell division or resistance to growth-inhibitory signals in any visible mass?"]}}, "pulmonary artery": {"yes_questions": {"contexual_properties": ["Is there a vessel in the image that appears enlarged, which could indicate conditions like pulmonary hypertension or congenital heart disease?", "Can you identify a blood vessel with a thickened wall, possibly due to chronic pressure overload or pulmonary arterial hypertension?", "Does the image show a vascular structure that might have increased pressure, as seen in left heart failure, chronic lung disease, or pulmonary embolism?", "Is there evidence of a vessel with decreased pressure, which could be associated with hypovolemia or vasodilator therapy?", "Can you see calcifications within a vessel, potentially suggesting chronic pulmonary hypertension or advanced atherosclerosis?", "Is there a blood vessel that appears narrowed, possibly due to stenosis or thromboembolic disease?", "Does the image reveal a vessel with a reduced diameter, which might be consistent with hypoplastic development or chronic hypoperfusion?", "Can you identify a vascular structure that appears stiffer than normal, possibly due to chronic hypertension or aging?", "Is there a vessel that looks dilated, which could be a response to increased pressure or volume overload as seen in pulmonary hypertension?", "Does the image show abnormal tissue composition within a vessel, potentially indicating sarcoma or chronic inflammation?", "Is there a blood vessel that appears more tortuous, which could be related to congenital heart defects or chronic pulmonary hypertension?", "Can you see a vessel wall that seems less elastic, possibly due to aging or chronic vascular disease?", "Is there evidence of increased vascular resistance, which might be present in pulmonary vascular disease or chronic hypoxia?", "Does the image show a thrombus within a vessel, suggesting acute or chronic pulmonary embolism?", "Can you observe changes in vessel color on imaging, which could occur during contrast studies or in the presence of a thrombus?", "Is there a vessel with increased flow velocity, potentially due to stenosis or high cardiac output states?", "Does the image reveal decreased flow velocity in a vessel, which might be associated with right ventricular failure or proximal obstruction?", "Can you identify aneurysmal changes in a vessel, possibly related to connective tissue disorders or longstanding pulmonary hypertension?", "Is there a vascular lumen that appears obstructed, which could be due to thromboembolism or tumor invasion?", "Does the image show increased wall thickness of a vessel, potentially indicating pulmonary arterial hypertension or chronic inflammatory conditions?"], "properties": ["Is there a blood vessel in the image with a diameter between 2.5 and 3.0 centimeters?", "Can you identify a vessel that measures approximately 5 to 6 centimeters in length?", "Does the image show a structure with a wall thickness of about 2 to 3 millimeters?", "Is there a vessel present that typically carries blood with an oxygen saturation around 75%?", "Can you see a structure that would have a pale pink to bluish appearance due to deoxygenated blood?", "Is there a vessel that appears highly elastic, suitable for pulsatile blood flow?", "Does the image contain a blood vessel whose wall is composed of endothelium, smooth muscle, collagen, and elastin fibers?", "Can you identify a cylindrical vessel with a slightly curved course?", "Is there a structure that bifurcates into two branches, one going to the right and one to the left?", "Does the image show a vessel with a cross-sectional area between 4.9 and 7.1 square centimeters?", "Is there a blood vessel present that would be expected to have low resistance to blood flow?", "Can you see a vessel whose tissue density is approximately 1.06 grams per cubic centimeter?", "Is there a structure that would have a tissue water content of about 70 to 80 percent by weight?", "Does the image contain a vessel whose wall has about 20 to 25 percent collagen and 10 to 15 percent elastin by dry weight?", "Can you identify a vessel whose smooth muscle cells make up about 30 to 40 percent of its cellular component?", "Is there a structure that would be expected to have a blood pH between 7.35 and 7.45?", "Does the image show a vessel that maintains a temperature close to 37 degrees Celsius?"], "relational": ["Does the image contain a vessel that is part of the cardiovascular system and involved in pulmonary circulation?", "Can you identify a structure that consists of a trunk and branches leading to both the right and left sides?", "Is there a vessel that is directly connected to the right ventricle of the heart?", "Does the image show a structure responsible for supplying blood to the lungs?", "Can you see branches that could correspond to segmental arteries within the lungs?", "Is there a vessel located adjacent to the aorta, left atrium, or bronchi?", "Does the image contain a vessel that is continuous with arterioles and capillaries within the lungs?", "Can you identify a structure situated within the thoracic cavity and mediastinum?", "Is there a vessel visible that transports deoxygenated blood from the heart toward the lungs for gas exchange?", "Does the image show a vessel surrounded by connective tissue, adventitia, or pericardium?"], "contexual_behavior": ["Does the image show a vessel that would increase blood flow to the lungs during physical activity or stress?", "Can you identify a structure whose ability to transport deoxygenated blood might be reduced in the presence of an obstruction such as a clot or severe hypertension?", "Is there evidence of a vessel that could experience impaired pressure regulation due to increased vascular resistance and thickening of its wall?", "Does the image contain a vessel that would constrict in response to low oxygen levels in the surrounding air spaces?", "Can you see a structure that might fail to deliver adequate blood to the lungs if the right side of the heart is not functioning properly?", "Is there a vessel that would show increased pressure during exercise as a result of elevated blood flow?", "Does the image include a structure whose blood flow could decrease during systemic hypotension or shock?", "Can you identify a vessel that might show altered function in the setting of chronic lung disease due to persistent low oxygen and changes in its wall structure?", "Is there a vessel that could fail to adapt to increased blood flow in conditions like congenital heart disease or pulmonary hypertension, resulting in elevated pressures?", "Does the image show a structure that could display abnormal blood flow patterns in the presence of congenital heart defects such as a persistent connection between the aorta and the pulmonary circulation?", "Can you see a vessel that might have reduced compliance and appear stiffened in the context of scarring lung disease?", "Is there a structure that would increase its resistance to blood flow during low oxygen conditions through narrowing of its lumen?", "Does the image show a vessel whose function could improve after removal of an obstruction, restoring normal blood flow?", "Can you identify a structure that might show impaired blood transport due to increased resistance and leakage in severe lung injury?", "Is there a vessel that would undergo narrowing and increased pressure in response to high altitude exposure?"], "functions": ["Does the image show a vessel that carries blood from the right side of the heart toward the lungs?", "Can you identify a structure that branches to deliver blood to both lungs?", "Is there a vessel present that enables gas exchange by supplying blood to pulmonary capillaries?", "Does the image include a conduit responsible for transporting blood to the lungs for oxygen absorption?", "Can you see a structure involved in removing carbon dioxide from the blood by delivering it to the alveoli?", "Is there a vessel that acts as the main pathway for blood flow between the heart and the lungs?", "Does the image contain a structure that connects the right ventricle to the pulmonary vasculature?", "Can you identify a vessel that helps regulate blood pressure in the lungs through its muscular walls?", "Is there a structure that would increase blood flow to the lungs during physical activity to meet higher oxygen demands?", "Does the image show a vessel capable of constricting or dilating in response to changes in oxygen levels to optimize gas exchange?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a visible microenvironment, such as a stem cell niche or perivascular region, that could support the proliferation of certain stromal cells?", "Can you identify a region that is part of the reproductive, hematopoietic, or musculoskeletal system?", "Does the image show a tissue type such as bone marrow, endometrium, or tumor stroma?"], "contexual_behavior": [], "functions": ["Does the image show cells that could be interacting with immune cells or modulating local immune responses?", "Can you identify cells that might be balancing matrix turnover or maintaining tissue homeostasis?", "Are there cells that seem to be supporting neighboring cell types through structural scaffolding or secreted factors?"]}}, "retroperitoneal": {"yes_questions": {"contexual_properties": ["Does the image show an area that appears enlarged due to the presence of a tumor, hematoma, or enlarged lymph nodes?", "Is there evidence of fluid accumulation in a space that could indicate edema, hemorrhage, or abscess formation?", "Can you identify increased fat deposition in a region that might be associated with obesity or a metabolic disorder?", "Does the image reveal a mass, cyst, or lymph node enlargement in a deep abdominal compartment?", "Is there a region that appears compressed by an expanding mass, enlarged adjacent organ, or as a result of trauma?", "Can you see signs of hemorrhage in a deep abdominal space, possibly following trauma or a ruptured aneurysm?", "Is there a change in density within a space that could be due to fluid, blood, fat, or tumor infiltration?", "Does the image show evidence of fibrosis in a region that might be affected by chronic inflammation?", "Is there an area that appears inflamed, possibly due to infection, autoimmune disease, or pancreatitis?", "Can you identify calcifications in a deep abdominal space that could be related to granulomatous disease, an old hematoma, or a neoplastic process?", "Is there visible gas in a region that could result from bowel perforation, infection with gas-forming organisms, or trauma?", "Does the image show abnormal tissue composition in a space that might be affected by tumor, fibrosis, or an infiltrative disease?", "Is there evidence of increased pressure in a compartment due to hemorrhage, edema, or an expanding mass?", "Can you see a decrease in the volume of a space that could be caused by scarring, fibrosis, or surgical resection?", "Does the image reveal cystic changes in a region that might be due to lymphangioma, pseudocyst, or a cystic neoplasm?"], "properties": ["Is there a region located behind the peritoneum and in front of the posterior abdominal wall muscles visible in the image?", "Can you identify an area that typically contains moderate to high amounts of fat serving as a protective cushion for nearby organs?", "Does the image show a space with substantial connective tissue providing structural support and compartmentalization?", "Is there a region where adipose tissue, connective tissue, blood vessels, lymphatics, and nerves are commonly found together?", "Can you see an area that would likely appear pale yellow to whitish due to its fat and connective tissue content?", "Does the image include a space whose tissue density would be expected to range from -100 to +40 Hounsfield units on CT imaging?", "Is there a region that could have a thickness between 1 and 3 centimeters?", "Can you identify an area where the water content is likely about 60\u201370% by weight, similar to other soft tissues?", "Does the image show a space that would be expected to have a temperature close to 37\u00b0C?"], "relational": ["Does the image show a region located in the posterior part of the abdominal area?", "Can you identify structures that are part of the abdominopelvic cavity but lie behind the peritoneal cavity?", "Is there evidence of organs such as the kidneys, adrenal glands, or ureters situated behind the peritoneal lining?", "Does the image contain portions of the pancreas, duodenum, or colon that are not fully enclosed by the peritoneum?", "Can you see a space bordered anteriorly by the parietal peritoneum and posteriorly by the transversalis fascia?", "Is there a visible separation between a cavity lined by parietal peritoneum and a region containing major blood vessels?", "Does the image show the abdominal aorta, inferior vena cava, or renal vessels running through a posterior abdominal compartment?", "Can you identify lymphatic structures such as para-aortic lymph nodes or lumbar lymphatic trunks in a posterior abdominal region?", "Is there evidence of nerves like the lumbar plexus, iliohypogastric nerve, or genitofemoral nerve traversing a space behind the peritoneal cavity?", "Does the image display connective tissues such as transversalis fascia, renal fascia, or adipose tissue in a posterior abdominal location?", "Can you distinguish a compartment that is adjacent to both the peritoneal cavity and the pelvic cavity?"], "contexual_behavior": ["Does the image show evidence of tissue that may provide support to adjacent organs, and could this support appear reduced in the context of connective tissue disorders or after extensive surgery?", "Is there visible fat in the image that might serve a protective function, and could this protection be diminished in cases of significant weight loss or cachexia?", "Can you identify a space that would normally contain infections, and might this containment be compromised if fascial barriers are breached or in immunocompromised individuals?", "Does the image suggest impaired lymphatic drainage, possibly due to malignancy, lymphatic obstruction, or tumor infiltration?", "Is there evidence of fascia that could lose its barrier function following trauma, such as blunt or penetrating injury?", "Can you observe signs of increased blood flow, such as vasodilation, that might occur during inflammation in this region?", "Does the image show tissue that could fail to limit the spread of hemorrhage if fascial planes are disrupted or in the presence of coagulopathy?", "Is there any indication of elevated compartment pressure that could impair organ function, as might be seen in hemorrhage or compartment syndrome?", "Can you see features that might suggest increased susceptibility to fibrosis, such as in chronic disease or retroperitoneal fibrosis?", "Is there evidence of abnormal fluid accumulation that could be facilitated by increased hydrostatic pressure, as seen in heart failure?", "Does the tissue appear to have impaired healing, potentially due to poor vascular supply or infection following surgical intervention?", "Is there visible fat that could show increased metabolic activity, possibly associated with obesity and adipocyte hypertrophy?", "Can you identify tissue that may have lost structural integrity due to infection, such as areas of necrosis or abscess formation?", "Is there evidence of lymphatic dysfunction, such as might occur in lymphedema due to lymphatic vessel obstruction or damage?", "Does the tissue display signs of an altered immune response, such as increased cytokine production or immune cell infiltration, in the context of systemic inflammation?"], "functions": ["Does the image show a structure that provides protection or support to vital organs?", "Can you identify an organ involved in regulating fluid balance by filtering blood and forming urine?", "Is there a structure responsible for removing metabolic waste from the bloodstream and excreting it as urine?", "Does the image contain a gland that produces hormones related to stress response or metabolism?", "Can you see an organ that helps regulate blood pressure through fluid volume control or hormone secretion?", "Is there a visible lymph node or tissue contributing to immune defense or pathogen surveillance?", "Does the image include an organ participating in metabolic processes such as gluconeogenesis or vitamin D activation?", "Can you identify a structure that maintains electrolyte balance by regulating ions like sodium or potassium?", "Is there evidence of fat tissue that stores energy and insulates underlying organs?", "Does the image show an organ that secretes a hormone stimulating red blood cell production in response to oxygen levels?"]}, "no_questions": {"contexual_properties": ["Does the image show a paired structure located opposite to another similar organ?", "Is there a visible organ that is anatomically situated contralateral to another ovary in the image?", "Can you identify a structure that mirrors the position of an ovary on the other side of the body?"], "properties": ["Can you see an object that might contain between 5 and 10 antral follicles?", "Can you identify an object with a blood flow rate that could vary between 5 and 15 mL/min depending on the menstrual phase?", "Is there a region that appears homogeneous on ultrasound with multiple small anechoic areas?"], "relational": ["Does the image contain a structure that is contralateral to another similar organ, indicating it is on the opposite side?", "Does the image show an object composed of ovarian cortex, medulla, germinal epithelium, or stroma?", "Is there a structure attached to surrounding tissues by the ovarian ligament, suspensory ligament, or mesovarium?"], "contexual_behavior": ["Is there evidence of a bilateral organ arrangement, with one member visible on the side opposite the primary structure?", "Is there a structure present on the side opposite to the one being primarily depicted?", "Can you identify an organ that is typically paired and may be located contralaterally to the main focus of the image?"], "functions": ["Can you see a structure nurturing primordial follicles through maturation stages?", "Is there a structure responsible for endocrine regulation of reproductive function and secondary sexual characteristics?", "Is there an object that responds to gonadotropin stimulation by promoting follicular development and steroid hormone synthesis?"]}}, "retroperitoneal leiomyosarcoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a mass located within the retroperitoneal space of the abdomen?", "Can you identify a lesion adjacent to perirenal fat or surrounded by fascia and connective tissue?", "Is there evidence of a structure affecting organs such as the kidney, pancreas, adrenal gland, or colon?", "Does the image display a mass in a region bordered anteriorly by the parietal peritoneum and posteriorly by the transversalis fascia?", "Can you see a lesion arising from the soft tissue compartment of the musculoskeletal system?", "Is there a mass involving or displacing major blood vessels like the abdominal aorta, inferior vena cava, or renal vessels?", "Does the image show proximity to para-aortic or retroperitoneal lymph nodes?", "Can you identify a tumor composed primarily of malignant smooth muscle cells?", "Is there a mass surrounded by adipose tissue, fibrous tissue, or fascia?", "Does the image reveal a lesion arising posterior to the abdominal cavity proper, within the retroperitoneal space?"], "contexual_behavior": ["Does the image show a mass located in the retroperitoneal space?", "Is there evidence of a tumor arising from smooth muscle tissue in the retroperitoneal region?", "Can you identify an abnormal growth in the area behind the peritoneum?", "Does the image contain a lesion that could be consistent with a malignant soft tissue tumor in the retroperitoneum?"], "functions": []}, "no_questions": {"contexual_properties": ["Does the image show a structure that appears larger than usual, possibly indicating recent construction or material accumulation?", "Can you see an accumulation of foreign materials, suggesting environmental contamination or that occupants have brought in external objects?", "Is there a visible change in color that could be due to weathering, sunlight exposure, or the addition of new materials?"], "properties": ["Can you identify an object with an outer framework of coarse materials and an inner lining of softer substances?", "Is there a structure whose diameter seems to fall between 10 and 30 centimeters?", "Is there a structure whose material composition might have a pH between 6.0 and 7.0, indicating neutral to slightly acidic conditions?"], "relational": ["Do you see cell groups interacting with basement membrane, capillaries, or immune cells at the microscopic level?", "Is there evidence of cell groups that are separated from each other by extracellular matrix?", "Are there clusters of cells present within epithelial tissue, endocrine glands, or tumors?"], "contexual_behavior": ["Is there evidence of a structure that could be more susceptible to parasitism in a densely populated area?", "Does the image contain an object that appears limited in size or resources, potentially supporting fewer offspring?", "Is there a structure that appears less effective at retaining moisture, possibly due to dried-out materials during drought conditions?"], "functions": ["Is there evidence of a structure that reduces predation risk by concealing eggs or young and limiting predator access?", "Is there a structure in the image that provides shelter and supports reproduction for certain organisms?", "Can you identify something that acts as a physical barrier to protect developing offspring from environmental hazards or predators?"]}}, "adenocarcinoma": {"yes_questions": {"contexual_properties": ["Does the image show a mass that appears larger, suggesting active cell division or tumor progression?", "Is there evidence of a lesion that has decreased in size, possibly indicating a response to therapy such as chemotherapy or surgical removal?", "Can you identify an area where the color of the tissue is altered, which might suggest hemorrhage, necrosis, or changes in blood supply?", "Is there a structure with increased visible blood vessels, consistent with angiogenesis or tumor growth under hypoxic conditions?", "Do you see regions within a mass that appear pale or necrotic, possibly due to insufficient blood supply and resulting cell death?", "Is there a firm or hardened area within the lesion, which could be due to increased fibrous tissue or desmoplastic reaction?", "Does the image show cells with abnormal shapes or sizes, suggesting increased cellular atypia or genetic instability?", "Can you identify areas with mucinous or secretory material, indicating glandular differentiation or a mucinous subtype?", "Is there a change in the growth pattern of a mass, such as loss of normal glandular structure or evidence of invasion into surrounding tissue?", "Do you see any calcified regions within the lesion, which may be due to dystrophic calcification in necrotic tumor tissue?", "Is there evidence that the degree of differentiation has changed, such as loss of glandular features or increased anaplasia?", "Can you observe features suggesting invasion beyond normal tissue boundaries, such as disruption of basement membranes or infiltration into adjacent structures?", "Are there cystic or fluid-filled components within the mass, possibly resulting from degeneration, necrosis, or mucin accumulation?", "Does the image reveal a high number of mitotic figures, indicating rapid cell proliferation or a high tumor grade?", "Is there distortion or disruption of normal glandular architecture, suggesting neoplastic invasion into the stroma?", "On imaging, does the lesion show increased metabolic activity, such as elevated glucose uptake on a PET scan?", "Can you detect changes in the density of the lesion on radiological scans, which might be due to necrosis, fibrosis, calcification, or cystic transformation?", "Is there evidence of ulceration or surface breakdown, possibly due to tumor invasion eroding the overlying mucosa or skin?", "Do you see areas of hemorrhage within the mass, which could result from fragile or invaded blood vessels?", "Is there any indication of elevated tumor marker production, such as secretory activity visible in the tissue or suggested by increased tumor burden?"], "properties": ["Does the image show a mass whose size could range from a few millimeters to several centimeters?", "Is there a structure present that might weigh anywhere from a few grams to several hundred grams depending on its size?", "Can you identify a lesion composed of round or oval cells arranged in glandular or acinar patterns?", "Is there a tissue area that appears whitish to tan, possibly with regions of hemorrhage or necrosis?", "Does the image contain a mass made up of malignant epithelial cells forming glands, along with stromal and inflammatory cells?", "Is there evidence of increased mitotic activity, such as 5 to 20 mitoses per 10 high-power fields, within a particular tissue?", "Can you see cells with a high nuclear-to-cytoplasmic ratio compared to normal glandular cells?", "Is there a region where glandular differentiation varies, ranging from well-formed glands to poorly differentiated structures?", "Does the image suggest a proliferation index (such as Ki-67) that could be between 20% and 80% in a particular area?", "Can you identify a tissue area that might be classified as low, intermediate, or high grade based on histological features?", "Is there evidence of increased mucin content, either within cells or in the extracellular space?", "Does the image show cells with variable DNA ploidy, such as aneuploid, diploid, or tetraploid patterns?", "Can you identify regions with 1 to 5 mitoses per high-power field, or possibly higher in more aggressive areas?", "Is there a structure that might exhibit elevated levels of tumor markers such as CEA compared to surrounding tissue?", "Does the tissue display increased vascular density, with numerous small blood vessels suggestive of angiogenesis?", "Can you see architectural patterns such as glandular, acinar, or papillary structures within the lesion?", "Is there evidence of moderate to marked cellular atypia, including pleomorphic nuclei and prominent nucleoli?", "Does the image show areas of necrosis, either focal or extensive, within a rapidly growing mass?", "Can you identify cells with eosinophilic or clear cytoplasm, possibly containing mucin vacuoles?", "Is there a population of cells with one or more prominent and enlarged nucleoli per cell?"], "relational": ["Does the image show a mass arising from glandular or mucosal tissue?", "Is there evidence of abnormal proliferation within glandular epithelium?", "Can you identify a lesion that appears to originate from epithelial or glandular cells?", "Is there a tumor located in an organ such as the lung, colon, pancreas, prostate, breast, or stomach?", "Does the image display a neoplastic growth in the thoracic, abdominal, or pelvic region?", "Can you see a mass that is adjacent to connective tissue, blood vessels, or lymphatic vessels?", "Is there a structure in proximity to regional lymph nodes or lymphatic capillaries?", "Does the image suggest involvement of the respiratory, digestive, endocrine, or reproductive system by a tumor?", "Can you identify a lesion with features of epithelial neoplasia?", "Is there visual evidence of a mass interacting with capillaries, arterioles, venules, or major blood vessels?", "Does the image show possible pathways for tumor spread, such as along lymphatic vessels, blood vessels, or serosal surfaces?", "Is there a mass that could be affecting neighboring organs?"], "contexual_behavior": ["Is there evidence of a malignant structure invading surrounding tissues, possibly indicating increased motility or changes associated with epithelial-mesenchymal transition?", "Can you identify features suggesting resistance to chemotherapy, such as the presence of cells with multidrug resistance characteristics or overexpression of efflux pumps?", "Does the image show a tumor with reduced secretion of markers, which might be associated with poor differentiation or response to therapy?", "Are there signs of altered metabolic activity, such as regions that might indicate adaptation to hypoxic conditions or increased glycolysis?", "Is there evidence of new blood vessel formation, possibly in response to low oxygen levels and secretion of pro-angiogenic factors like VEGF?", "Can you observe a decrease in cell proliferation that could be attributed to targeted therapy or inhibition of oncogenic signaling pathways?", "Does the image suggest an immune response against tumor cells, possibly due to immune checkpoint inhibition or activated immune cells?", "Are there visual cues of increased metastatic potential, such as tumor spread in the context of chronic inflammation or matrix remodeling?", "Can you detect changes in tumor growth rate that might be influenced by hormonal regulation, especially in hormone-sensitive tissues?", "Is there evidence of impaired apoptosis, such as abnormal cell survival patterns that could be linked to mutations in apoptotic regulators like p53?", "Do you see signs of increased secretion of growth factors in areas with abundant nutrients, supporting enhanced proliferation and survival?", "Is there a reduction in invasive behavior or tumor spread that could be associated with recent radiation therapy and DNA damage?", "Are there indications of extracellular matrix remodeling, such as increased proteolytic activity or upregulation of matrix metalloproteinases?", "Does the image suggest reduced tumor activity or regression in response to anti-angiogenic therapy targeting blood vessel formation?", "Can you identify features of immune evasion, possibly due to immunosuppression or weakened host immune responses?", "Are there signs of metabolic adaptation, such as reliance on alternative substrates like glutamine or fatty acids during glucose deprivation?", "Is there evidence of increased production of pro-inflammatory cytokines, possibly due to interactions with stromal or immune cells in the tumor microenvironment?", "Do you observe a decrease in metastatic spread following surgical removal of a primary tumor, suggesting loss of pro-metastatic factors?", "Are there features indicating enhanced drug efflux activity, such as overexpression of ATP-binding cassette transporters in multidrug-resistant cells?", "Can you detect reduced proliferation or signs of quiescence and autophagy in response to nutrient starvation within the tumor?"], "functions": ["Does the image show a region where cells appear to be proliferating uncontrollably or invading surrounding tissue?", "Is there evidence of structures that could indicate the breakdown of the basement membrane or extracellular matrix?", "Can you identify an area where normal glandular architecture is disrupted or replaced by abnormal cells?", "Does the image reveal new blood vessel formation that might suggest neovascularization?", "Is there a region where immune cells seem absent or ineffective, possibly due to immune evasion mechanisms?", "Can you see signs that suggest cells have entered blood or lymphatic vessels, indicating possible spread to distant sites?", "Is there visual evidence of abnormal cellular signaling, such as increased cell density or loss of normal tissue organization?", "Does the image show disruption of tissue homeostasis, such as abnormal cell turnover or changes in the local microenvironment?", "Are there areas where cells appear resistant to programmed cell death, such as clusters of densely packed abnormal cells?", "Can you observe features that suggest dysregulation of the cell cycle, like increased mitotic figures or abnormal growth patterns?", "Is there evidence of extracellular matrix remodeling, such as irregular tissue boundaries or degraded matrix components?", "Does the image show signs of local inflammation, such as immune cell infiltration or increased cellularity?", "Are there indications of microenvironmental changes, like regions of hypoxia, altered pH, or activated stromal cells?", "Can you identify areas where cells might be increasing their glucose uptake or displaying altered metabolic activity?", "Does the image reveal sustained proliferative signaling, such as continuous growth without evidence of normal growth suppression?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a marked degree of micrognathia present?", "Is the mouth downturned or does it have a small oral opening?", "Are multiple facial features flattened or lacking normal contour?"], "relational": ["Does the image show other congenital anomalies such as limb deformities, underdeveloped lungs, or clubfoot?", "Can you identify low-set ears or epicanthal folds in the facial structures present?", "Are there signs of anomalies in the craniofacial system that could be linked to the urinary system?"], "contexual_behavior": ["Does the image show facial features that could be associated with prolonged or severe deficiency of amniotic fluid during gestation?", "Are there visual signs of severe facial flattening that could be linked to impaired airway passages?", "Is there evidence of malformations around the mouth or nose that might contribute to feeding or breathing difficulties in a newborn?"], "functions": ["Does the image show a newborn with facial features that could compromise breathing or cause airway obstruction?", "Is there evidence of facial structure that might interfere with feeding or sucking ability in an infant?", "Is there visual evidence of poor oral competence, such as drooling or difficulty controlling saliva?"]}}, "typical infiltrating adenocarcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a lesion invading epithelial, connective, or muscle tissue?", "Can you identify an abnormal structure affecting the gastrointestinal, respiratory, or reproductive system?", "Is there a mass adjacent to a basement membrane or surrounded by parenchymal tissue?", "Does the image reveal clusters of malignant glandular cells along with stromal fibroblasts or inflammatory cells?", "Can you see a suspicious area located in regions such as the colon, lung, breast, or prostate?", "Is there visual evidence of a desmoplastic reaction or stromal invasion around a lesion?", "Does the abnormal structure appear to interact with or remodel the surrounding matrix?", "Are regional lymph nodes, lymphatic vessels, or sentinel nodes visibly involved near the lesion?", "Can you observe capillaries, small arteries, or venules within or around the abnormal area?", "Is there indication of potential secondary involvement of organs like the liver, lungs, bones, or brain?", "Does the lesion appear to penetrate multiple tissue layers such as mucosa, submucosa, muscularis, or serosa?"], "contexual_behavior": [], "functions": ["Does the image show a structure characterized by uncontrolled cell proliferation and invasion into surrounding tissues?", "Can you identify an area where normal tissue architecture is disrupted and replaced by irregular glandular formations?", "Is there evidence of tissue infiltration or destruction of the extracellular matrix in the image?", "Does the image contain features suggesting local infiltration into adjacent structures?", "Can you see signs of functional impairment or replacement of healthy tissue by abnormal growth?", "Is there visual evidence of new blood vessel formation that could be stimulated by pro-angiogenic factors such as VEGF?", "Does the image show regions where immune cell infiltration or local inflammation might be present?", "Can you identify structures that might indicate immune evasion, such as reduced immune cell presence around abnormal tissue?", "Is there evidence of abnormal cells entering blood or lymphatic vessels, suggesting the potential for distant spread?", "Does the image reveal architectural distortion with loss of normal tissue organization?", "Can you see glandular structures that appear irregular or atypical compared to surrounding tissue?", "Is there a region where rapid cell proliferation could be inferred from densely packed nuclei or increased mitotic figures?", "Does the image suggest resistance to programmed cell death, such as the presence of cells with abnormal morphology persisting in unfavorable conditions?", "Can you identify areas where the tumor microenvironment appears altered, such as changes in stromal cell appearance or extracellular matrix composition?", "Is there evidence of metabolic reprogramming, such as regions with increased cellular density that could indicate high metabolic activity?", "Does the image show signs of local or systemic inflammation, such as the presence of pro-inflammatory mediators or recruited immune cells?", "Can you see features that might indicate oncogenic activation or inhibition of tumor suppressor pathways, such as abnormal cell shapes or sizes?", "Is there visual evidence of angiogenesis, such as an increased number of small blood vessels within or around the abnormal tissue?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Are there two organisms that interact with epithelial or endothelial tissues?", "Are there two structures present that could belong to the Spirochaetaceae family?", "Does the image reveal two bacteria with both a cytoplasmic membrane and a peptidoglycan layer?"], "contexual_behavior": [], "functions": ["Are there two objects that could be performing glycolysis or anaerobic respiration for energy production within a host?", "Are there two organisms that could be disseminating through tissues and potentially inducing inflammation?", "Does the image contain two organisms that might adapt to different environments by altering gene expression or membrane composition?"]}}, "colon": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify regions such as the ascending, transverse, descending, or sigmoid segments within the image?", "Is there a structure that appears adjacent to the small intestine or rectum?", "Can you see any anatomical features located near the kidneys or bladder?", "Does the image contain vessels that could correspond to the superior or inferior mesenteric arteries supplying a digestive organ?", "Is there evidence of innervation by the enteric nervous system or by fibers from the vagus or pelvic splanchnic nerves in any visible structure?", "Can you identify a region that is continuous with the rectum at its terminal end?", "Is there a visible junction where the ileum meets a larger tubular structure, possibly involving the ileocecal valve?", "Does the image show a wall composed of multiple layers such as mucosa, submucosa, muscularis propria, and serosa?", "Are there lymphatic structures present, such as mesenteric or colic lymph nodes, associated with a tubular digestive organ?", "Can you identify anatomical boundaries such as the ileocecal junction or rectosigmoid junction in the image?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for absorbing water from digested food?", "Can you identify an area involved in regulating electrolyte levels, such as sodium and chloride absorption?", "Is there a region where undigested carbohydrates might be fermented by anaerobic bacteria?", "Does the image contain a structure that compacts waste material and stores it until elimination?", "Can you see evidence of an environment that supports the proliferation of beneficial gut microbiota?", "Is there a visible area where vitamins like vitamin K and B vitamins could be absorbed after being synthesized by resident bacteria?", "Does the image show a structure that propels fecal matter toward the rectum for excretion?", "Can you identify a region involved in maintaining fluid balance through water and electrolyte reabsorption?", "Is there a structure present that contributes to immune defense via gut-associated lymphoid tissue or antimicrobial peptide production?"]}, "no_questions": {"contexual_properties": ["Is there evidence of a tear that appears deeper, suggesting ongoing mechanical trauma or severe retching?", "Does the lesion show features of healing, such as epithelial regeneration or the presence of granulation tissue?", "Does the lesion display swelling or edema, consistent with local tissue injury and inflammation?"], "properties": ["Does the image show a tear that is limited to the mucosa or possibly extends into the submucosa?", "Can you see a structure with reddish or bright red coloration suggestive of fresh bleeding?", "Does the image display a single linear tear rather than multiple tears at the mucosal surface?"], "relational": ["Is there evidence of disruption limited to the mucosal or submucosal layers in the upper gastrointestinal tract?", "Can you identify a lesion located at the distal end of the esophagus?", "Are there signs of injury adjacent to the Z-line or the cardia of the stomach?"], "contexual_behavior": ["Is there a visible longitudinal tear near the junction between the esophagus and stomach that might be associated with recent forceful vomiting?", "Is there evidence of local edema or inflammation in the esophageal lining that could cause pain during swallowing?", "Can you identify signs of acute hemorrhage or blood loss in the region where the esophagus meets the stomach?"], "functions": ["Can you identify a source of hematemesis originating from a laceration in the mucosa?", "Does the image suggest activation of coagulation or local inflammation in response to bleeding at the gastroesophageal junction?", "Are there visual indications of increased peristalsis or other physiological responses to acute bleeding?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": ["Is there visual evidence of disrupted placental attachment accompanied by hemorrhage?", "Can you identify signs of blood accumulation near the site where the placenta attaches?", "Does the image show evidence of abnormal bleeding in association with the placenta?"], "properties": ["Is there a sign of blood loss that could result in a hemoglobin concentration below 10 grams per deciliter?", "Is there evidence of a fluid accumulation with a volume that could range from 500 to over 2000 milliliters?", "Does the image show a region where blood loss might be occurring at a rate exceeding 100 milliliters per minute?"], "relational": ["Can you see any changes affecting the fetal membranes, umbilical cord, or fetus that might result from a nearby hemorrhagic event?", "Can you identify blood accumulation near the maternal-fetal interface?", "Does the image reveal abnormalities in the retroplacental area or intervillous space?"], "contexual_behavior": ["Does the image display features consistent with blood loss adjacent to the placenta?", "Can you identify signs of bleeding in association with placental tissue?", "Is there a visible area suggesting disrupted attachment between the placenta and the uterine wall accompanied by hemorrhage?"], "functions": ["Can you identify disruption of placental integrity that might reduce oxygen and nutrient transfer to the fetus?", "Can you identify reduced fetal blood flow that might result in fetal anemia or compromised fetal circulation?", "Is there evidence of compromised placental perfusion that could cause fetal distress or hypoxemia?"]}}, "coronary artery anomalous origin left from pulmonary artery": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure in the cardiovascular system with an unusual connection between a major artery and the pulmonary artery?", "Can you identify a vessel supplying the left ventricle or left atrium that appears to originate from the pulmonary artery rather than the ascending aorta?", "Is there evidence of a coronary artery arising from the pulmonary artery instead of the left aortic sinus?", "Does the image reveal a vessel connected to the pulmonary artery that branches toward the interventricular septum?", "Can you see a coronary artery supplying the myocardium of the left heart structures that lacks a direct connection to the aorta?", "Is there a vessel whose origin is abnormally close to the pulmonary artery, with downstream branches supplying the left side of the heart?", "Does the image suggest an absence of the typical connection between the left coronary artery and the aorta?", "Are there any signs of ischemic changes in the myocardium of the left ventricle or left atrium that could result from an abnormal arterial origin?", "Can you identify anatomical variations such as an anomalous right coronary artery or an interarterial course of a coronary vessel?", "Is there a vessel in the image that could be the circumflex artery, and does its origin appear unusual in relation to the pulmonary artery?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structure that could lead to reduced oxygenated blood supply to the myocardium, potentially resulting in myocardial ischemia or heart failure?", "Is there a vessel originating from the pulmonary artery that appears to supply deoxygenated blood to the heart muscle?", "Can you identify any features suggesting impaired cardiac perfusion due to low-pressure, low-oxygen blood flow?", "Does the image contain signs that the heart\u2019s ability to meet metabolic demands during exercise might be compromised, such as features associated with exercise intolerance or angina?", "Is there visual evidence of collateral vessels forming between the right coronary artery and the left coronary territory, indicating compensatory mechanisms?", "Can you observe abnormal coronary blood flow patterns or features suggestive of a coronary steal phenomenon?", "Does the image show collateral circulation supplying oxygenated blood from the right coronary artery to the left side of the heart?", "Are there indications of altered pressure gradients, such as left-to-right shunting or decreased coronary perfusion pressure?", "Can you identify structural changes that might be associated with ventricular hypertrophy as a compensatory response?", "Is there evidence of features that could impair the heart\u2019s response to stress or increased workload, potentially increasing the risk of arrhythmias or sudden cardiac arrest?"]}, "no_questions": {"contexual_properties": ["Are there larger, well-defined bright areas that might suggest the presence of a fibroadenoma or cyst degeneration?", "Does the image show an increased number of small, bright spots that could be associated with ductal carcinoma in situ or a benign proliferative process?", "Does the image show an increasing number of bright spots over time, possibly indicating neoplastic progression or chronic inflammation?"], "properties": ["Does the image show multiple bright, highly radiopaque spots measuring less than 1 millimeter in size?", "Does the image display areas where the spacing between bright foci is less than 1 millimeter to several millimeters apart?", "Are there several dozen or fewer bright, punctate or amorphous structures visible?"], "relational": ["Does the image show small, dense areas within the breast parenchyma or ducts that could indicate mineral deposits?", "Is there evidence of small, clustered densities near the terminal duct lobular units or within the subareolar region?", "Does the image appear to be acquired using digital mammography or tomosynthesis, as opposed to ultrasound or MRI?"], "contexual_behavior": ["Does the image appear to have been acquired after administration of a contrast agent, potentially increasing the distinction between vascular and non-vascular regions?", "Is there evidence that computer-aided diagnosis tools were applied to assist in highlighting subtle or clustered bright spots?", "Does the image show dense tissue that could reduce the visibility of small bright spots against the surrounding background?"], "functions": ["Does the image show changes that might be used to evaluate response to therapy or treatment?", "Is there evidence of patterns or distributions that could help in recognizing malignant lesions?", "Does the image reveal any features that could be critical for early detection during breast cancer screening?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display fetal blood vessels linked to another structure?", "Is there a visible connection between a structure and the umbilical cord?", "Can you observe a conduit for fetal blood flow connecting to a larger tissue mass?"], "contexual_behavior": [], "functions": ["Is there an object involved in endocrine communication by releasing hormones into both maternal and fetal bloodstreams?", "Is there a feature present that enables the movement of glucose, amino acids, fatty acids, or vitamins from mother to fetus?", "Does the image contain a structure that facilitates oxygen diffusion to the fetus and carbon dioxide removal from fetal blood?"]}}, "coronary artery": {"yes_questions": {"contexual_properties": ["Is there a vessel in the image that appears narrowed, possibly due to plaque buildup or vasospasm?", "Can you identify a structure that might be blocked by a thrombus or show evidence of plaque rupture?", "Does the image show a vessel wall that appears thickened, which could result from chronic inflammation or hypertension?", "Is there evidence of lipid accumulation or plaque deposits within a vessel, suggesting atherosclerosis?", "Can you see signs of calcification within a vessel wall, which may indicate advanced atherosclerosis?", "Does any vessel in the image appear less elastic, possibly due to aging or calcification?", "Is there a vessel with a decreased diameter, potentially caused by smooth muscle proliferation or vasoconstriction?", "Can you observe increased stiffness in a vessel, which might be due to fibrosis or vascular calcification?", "Does the image show a vessel that is abnormally dilated, as seen in ectasia or following angioplasty?", "Is there evidence of an aneurysm in a vessel, possibly resulting from wall weakening due to a connective tissue disorder?", "Can you identify a vessel with reduced blood flow, which could be caused by stenosis or thrombosis?", "Is there a vessel wall that appears inflamed, potentially due to vasculitis or infection?", "Does the image show cholesterol deposition or fatty streaks within a vessel, indicating early atherosclerosis?", "Can you observe changes in the lumen size of a vessel, such as narrowing from plaque growth or dilation from an aneurysm?", "Is there evidence of tortuosity in a vessel, which may be associated with aging or congenital anomalies?", "Does any vessel wall appear thickened by fibrosis, possibly following chronic injury?", "Can you see increased intimal thickness in a vessel, suggesting progression of atherosclerosis?", "Is there a visible thrombus within a vessel, potentially formed after plaque rupture or erosion?", "Does the vessel wall show changes in composition, such as those seen in vascular remodeling or calcification?"], "properties": ["Is there a vessel visible that measures approximately 3 to 4 millimeters in diameter?", "Can you identify a structure with a length ranging from about 10 to 100 millimeters, depending on its branch?", "Does the image show a vessel wall that appears to be 1 to 2 millimeters thick?", "Is there a structure that could support a blood flow rate of around 250 milliliters per minute at rest?", "Can you see a vessel with a pale pink to reddish coloration due to its blood supply?", "Is there a tubular, curved structure following the surface of the heart visible in the image?", "Does the image show a vessel that appears capable of pulsatile expansion and recoil, indicating high elasticity?", "Is there a structure that would typically experience pressures between 80 and 120 mmHg during the cardiac cycle?", "Can you identify a vessel wall composed of three distinct layers: intima, media, and adventitia?", "Does the image show a structure likely to contain endothelial cells, smooth muscle cells, and fibroblasts?", "Is there a vessel whose wall might contain about 20-30% collagen by dry weight?", "Can you see a structure where the elastin content of the wall is approximately 2-5% of its dry weight?", "Is there a vessel present that would have low calcium concentration in healthy tissue?", "Does the image include a structure with a lumen area of approximately 7 to 12 square millimeters?", "Can you identify a vessel that bifurcates into major branches, such as those supplying the anterior and lateral regions of the heart?", "Is there a structure with a high density of smooth muscle cells in its middle layer, supporting contractility?", "Does the tissue of any vessel appear to have a water content of about 70-80% by weight?", "Is there a structure present whose temperature would be close to 37 degrees Celsius?", "Can you see a vessel whose tissue pH would be expected to be between 7.35 and 7.45?", "Is there a structure where the fat content in the wall is minimal and mainly located in the outermost layer?"], "relational": ["Does the image show a structure that is part of the cardiovascular system?", "Can you identify a vessel that supplies blood to the myocardium or other layers of the heart wall?", "Is there a vessel present that delivers blood to the endocardium or epicardium?", "Does the image include branches such as the left anterior descending artery or circumflex artery?", "Can you see a vessel that gives rise to the right marginal artery?", "Is there a visible association between an artery and veins like the great cardiac vein or middle cardiac vein?", "Does the image show a vessel located near the aorta or pulmonary trunk?", "Can you identify a structure adjacent to the pericardium?", "Is there a vessel that delivers blood to cardiac muscle or the conduction system of the heart?", "Does the image show a vessel originating from the ascending aorta at the aortic sinuses?", "Can you see a vessel that penetrates the epicardium or myocardium?", "Is there a vessel lined by endothelial cells forming a tunica intima?", "Does the image include arteries such as the posterior descending artery or obtuse marginal artery?"], "contexual_behavior": ["Is there a vessel in the image that may deliver less oxygenated blood to the heart muscle under conditions such as severe hypoxemia or a right-to-left shunt?", "Can you identify a structure whose blood flow might decrease during physical exertion if there is evidence of narrowing or obstruction?", "Does the image show a vessel that could fail to supply adequate nutrients to the heart muscle if atherosclerotic plaques are present?", "Is there a structure that would increase its diameter in response to hypoxia, possibly through the action of local vasodilators like adenosine?", "Can you see a vessel that might lose its ability to constrict properly during stress if endothelial dysfunction or autonomic imbalance is present?", "Does the image contain a vessel that could show impaired blood flow in the event of a myocardial infarction due to acute thrombotic blockage?", "Is there a structure that might develop endothelial dysfunction and plaque formation in response to high cholesterol levels?", "Can you identify a vessel that could decrease its perfusion during a spasm, potentially leading to transient myocardial ischemia?", "Does the image show evidence of collateral vessels that might form to compensate for chronic blockage of a main artery?", "Is there a vessel that might fail to dilate in response to vasodilators if endothelial dysfunction is present?", "Can you see a structure whose blood flow could be reduced during severe hypotension due to decreased perfusion pressure?", "Is there a vessel that would increase its blood supply to the heart muscle by dilating during periods of increased cardiac demand?", "Does the image show a vessel that might have impaired autoregulation in the context of diabetes mellitus due to microvascular and endothelial changes?", "Can you identify a structure whose function could be reduced during systemic inflammation as a result of endothelial activation and microvascular impairment?", "Is there a vessel whose blood flow pattern might be altered during arrhythmias because of irregular cardiac cycles?", "Does the image contain a vessel that could lose its ability to adapt to exercise-induced stress if atherosclerosis or microvascular disease is present?", "Is there a structure that might be more susceptible to thrombosis in hypercoagulable states due to increased clot formation?", "Can you see a vessel that would deliver less oxygen to the heart muscle during anemia because of reduced arterial oxygen content?", "Is there a structure whose function might improve after smoking cessation as endothelial function and vasodilation capacity recover?", "Does the image show a vessel that could have a reduced vasomotor response due to aging-related structural and functional changes?"], "functions": ["Does the image show a vessel responsible for delivering oxygen-rich blood to the heart muscle?", "Can you identify a branching network that supplies blood directly to cardiac tissue?", "Is there a structure involved in ensuring nutrient delivery and oxygenation of the myocardium?", "Does the image contain a vessel that supports the metabolic needs of the heart by supplying nutrients and removing waste products?", "Can you see evidence of a system that facilitates venous drainage from the heart muscle?", "Is there a vessel that might increase blood flow to the heart during physical activity?", "Does the image show a structure capable of regulating blood flow to the heart through changes in vessel diameter?", "Can you identify a vessel that adjusts its diameter in response to increased cardiac workload?", "Is there evidence of endothelial-mediated vasodilation or metabolic regulation in the vessels supplying the heart?", "Does the image suggest the presence of collateral circulation that could protect the heart from ischemia if a primary vessel is blocked?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see a region that would be at core body temperature, approximately 37 degrees Celsius?", "Is there a structure that could contain fibroblasts and macrophages?", "Is there a structure with a density close to that of soft tissue, around 1.03 grams per cubic centimeter?"], "relational": ["Can you identify anatomical spaces such as the greater sac or rectouterine pouch defined by a membranous structure?", "Can you identify a membrane that encloses organs such as the stomach, liver, or intestines?", "Does the image show a structure that is part of the digestive system and forms a lining within the abdominal cavity?"], "contexual_behavior": ["Can you identify signs of excess fluid accumulation that might result from injury, peritonitis, malignancy, or liver disease?", "Are there indications that abdominal organs are less effectively isolated from each other, perhaps due to widespread inflammation or neoplastic infiltration?", "Is there evidence of reduced lubrication between abdominal organs, possibly due to chronic disease or sclerosis?"], "functions": ["Is there evidence of a physical barrier that could help contain infections within the abdominal cavity?", "Is there a structure that could house immune cells or contribute to cytokine production for pathogen defense?", "Does the image show a structure that provides a protective lining for abdominal organs?"]}}}
[ { "answer": "typical histology for colon adenocarcinoma", "extracted_concepts": [ "colon adenocarcinoma", "typical histology" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "colon adenocarcinoma", "typical histology" ], "question": "does this image show typical histology for colon adenocarcinoma?" }, { "answer": "no", "extracted_concepts": [ "colon adenocarcinoma", "endocrine", "amyloid angiopathy", "typical histology" ], "question": "does amyloid angiopathy r. endocrine show typical histology for colon adenocarcinoma?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "alpha smooth muscle actin immunohistochemical" ], "question": "is alpha smooth muscle actin immunohistochemical present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "colon" ], "question": "is colon present?" }, { "answer": "no", "extracted_concepts": [ "lymphangiomatosis" ], "question": "is lymphangiomatosis present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" } ]	["amyloid angiopathy", "gastrointestinal system", "endocrine", "colon", "gastrointestinal", "colon adenocarcinoma", "lymphangiomatosis", "alpha smooth muscle actin immunohistochemical", "typical histology"]	{"amyloid angiopathy": {"yes_questions": {"contexual_properties": ["Does the image show blood vessels with evidence of abnormal protein accumulation within their walls?", "Can you identify vessels that appear thickened due to material infiltrating the vascular layers?", "Is there visual evidence of vessel wall thickening that could be attributed to infiltration of abnormal substances?", "Do any vessels appear narrowed, possibly due to deposits encroaching on the lumen?", "Can you see blood vessels that display discoloration or abnormal staining patterns?", "Are there vessels that show signs of calcification, suggesting chronic deposition of abnormal material?", "Is there evidence of small hemorrhages or microbleeds associated with fragile vessel walls?", "Do any vessels appear to have altered composition, such as loss of normal smooth muscle structure?", "Can you identify vessels that seem less elastic or more rigid than expected?", "Are there vessels that exhibit abnormal staining with dyes commonly used to detect protein deposits, such as Congo red?", "Do any vessels appear to have increased permeability or signs of endothelial dysfunction?", "Is there visual evidence of changes in vessel diameter or architecture that could be due to abnormal material accumulation?", "Can you see signs of vessel stiffening or rigidity that might result from infiltration of non-native proteins?", "Are there vessels where the normal vascular components seem to be replaced by other material?", "Do any vessels show features consistent with the accumulation of amyloid-beta within their walls?"], "properties": [], "relational": ["Does the image show evidence of a pathological process affecting the central nervous system?", "Can you identify abnormalities involving small- to medium-sized blood vessels, such as cerebral arteries or arterioles?", "Is there visible involvement of the cerebral cortex or leptomeninges?", "Does the image display changes in the lobar regions of the brain, such as the occipital, parietal, or frontal lobes?", "Can you see signs of vascular dysfunction due to amyloid deposition in blood vessels of the brain?", "Are there alterations in structures adjacent to affected vessels, such as the brain parenchyma or perivascular spaces?", "Is there evidence of amyloid-beta accumulation, particularly the A\u03b240 or A\u03b242 isoforms, within vascular walls?", "Can you identify vessels containing endothelial cells, smooth muscle cells, or pericytes that appear abnormal?", "Does the image suggest features consistent with cerebral small vessel disease or neurodegeneration?", "Are there visible interactions between affected vessels and other vascular structures like capillaries or venules in the cerebral circulation?"], "contexual_behavior": [], "functions": ["Does the image show evidence of vascular dysfunction in the brain, such as impaired vessel integrity or signs of hemorrhage?", "Can you identify features consistent with vessel narrowing or obstruction that could reduce cerebral blood flow?", "Is there visual evidence of amyloid deposition within cerebral vessels?", "Does the image display signs of weakened vessel walls or the presence of microaneurysms?", "Can you observe any structural disruption of blood vessels that might indicate increased vascular permeability or barrier breakdown?", "Is there evidence of smooth muscle cell loss or abnormal accumulation within the tunica media or adventitia of vessels?", "Does the image reveal fragile-appearing vessels or microbleeds that could suggest a risk of hemorrhagic stroke?", "Can you see indications of impaired perivascular drainage, such as accumulation of metabolic waste or perivascular blockage?", "Is there evidence of hypoxic or ischemic changes in brain tissue that could result from vascular alterations?", "Does the image suggest reduced cerebral perfusion or impaired vascular reactivity?", "Are there signs of microglial activation or inflammatory changes associated with vascular inflammation?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image indicate an elevated erythrocyte sedimentation rate, for example, above 30 mm/hr?", "Is there any indication of increased C-reactive protein levels, such as values exceeding 10 mg/L?", "Can you see findings consistent with a parasite load in stool between 10^3 and 10^6 trophozoites per gram?"], "relational": ["Is there visible involvement of the liver parenchyma in the image?", "Are there signs of disease affecting the cecum, ascending colon, or rectum?", "Can you identify any damage or abnormality in the intestinal mucosa or submucosa?"], "contexual_behavior": [], "functions": ["Does the image show recruitment of inflammatory cells or release of pro-inflammatory mediators in the gastrointestinal tract?", "Is there any indication of hematogenous spread, such as lesions along the portal circulation or in extraintestinal sites?", "Are there visual cues of apoptosis or disruption of tight junctions in the epithelial lining?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": ["Can you identify abnormal tissue growth that may indicate the dissemination of a carcinoma from its primary site in the male pelvis?", "Does the image show evidence of a malignant neoplasm originating from a glandular organ in the male reproductive system that has spread to other tissues?", "Is there a lesion present that suggests secondary involvement by a cancer typically arising from the prostate?"], "properties": [], "relational": ["Are there signs of abnormality in the lymph nodes, such as pelvic, obturator, internal iliac, or para-aortic nodes?", "Can you identify disruption or involvement of anatomical boundaries like the prostatic capsule, Denonvilliers\u2019 fascia, or pelvic floor muscles?", "Does the image show evidence of disease affecting the male genitourinary system?"], "contexual_behavior": [], "functions": []}}, "endocrine": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure that produces hormones such as insulin or cortisol?", "Can you identify an object that might secrete thyroxine, estrogen, or testosterone?", "Is there a structure that could be responsible for releasing growth hormone or adrenaline?", "Does the image contain a gland with a lobular or clustered appearance?", "Can you see a structure that appears highly vascularized, suggesting rapid hormone release into the bloodstream?", "Is there an object whose size could range from a few millimeters to several centimeters?", "Can you identify a structure that might weigh less than 1 gram up to about 20 grams?", "Does the image show tissue composed of specialized secretory cells such as chromaffin or follicular cells?", "Is there a structure that appears pale pink or reddish-brown in color?", "Can you see a gland with a soft, friable texture?", "Is there an object with an oval, round, or irregular shape?", "Does the image show a structure that might have a high water content, around 70\u201380% by weight?", "Can you identify tissue that could have moderate lipid content, approximately 5\u201315% by weight?", "Is there a structure that might contain about 10\u201320% protein by weight?", "Can you see a gland that likely has low carbohydrate content, less than 5% by weight?", "Does the image show tissue that could have trace amounts of minerals such as calcium, potassium, or sodium?", "Is there an object that might contain two to five distinct cell types?", "Can you identify a structure that would function optimally at a temperature of 36\u201337\u00b0C?", "Does the image show a gland that would have a slightly alkaline pH, around 7.2 to 7.4?", "Is there a structure where the concentration of secreted molecules could be in the nanomolar to picomolar range?"], "relational": ["Does the image contain a gland located in the brain, neck, abdomen, pelvis, or thorax?", "Can you identify a structure that is ductless and releases substances directly into the blood?", "Is there an organ that could be part of the reproductive, metabolic, skeletal, or cardiovascular system due to hormonal influence?", "Does the image show a structure that could be the pituitary gland, thyroid gland, adrenal gland, pancreas, pineal gland, parathyroid gland, ovaries, or testes?", "Can you see a tissue that might interact with blood or nervous tissue as part of its function?", "Is there a structure that could be supplied by the hypophyseal portal system, thyroid arteries, adrenal arteries, or pancreatic blood vessels?", "Does the image contain a region where neuroendocrine integration or hypothalamic-pituitary axis activity might occur?", "Can you identify a structure that could contain endocrine cells, chromaffin cells, follicular cells, or islet cells?", "Is there an organ that is structurally linked to the hypothalamus, pituitary gland, thyroid gland, adrenal glands, or pancreas?", "Does the image show a gland that influences target organs through feedback loops?"], "contexual_behavior": [], "functions": ["Does the image show any structures responsible for hormone secretion?", "Can you identify a feature involved in regulating metabolism or maintaining physiological balance?", "Is there evidence of a gland or tissue participating in negative feedback or hormonal control?", "Does the image contain a structure that could release hormones such as insulin, glucagon, or thyroid hormones?", "Can you see an organ that might control growth or development through hormone secretion?", "Is there a visible feature associated with the stress response, such as the adrenal glands?", "Does the image include a structure involved in sexual development or reproductive cycles?", "Can you identify a feature that might help maintain homeostasis by adjusting physiological processes?", "Is there a structure that could regulate blood sugar through the production of insulin or glucagon?", "Does the image show any features that could influence mood or behavior via hormone action on the brain?", "Can you see evidence of coordination between hormone-producing structures and other body systems such as the nervous or digestive system?", "Is there a structure that might help maintain electrolyte balance by regulating sodium, potassium, or water levels?", "Does the image include a feature that could regulate blood pressure through hormonal mechanisms?", "Can you identify a structure that might adjust hormone secretion in response to environmental changes like light or temperature?", "Is there a feature involved in synchronizing physiological processes with the day-night cycle?", "Does the image show a structure that could modulate immune function through hormone release?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the specimen appear to be contained within the ocular system or nervous system?", "Does the image contain tissues like neural, connective, epithelial, or vascular tissue?", "Is there a visible anatomical connection to the optic nerve head or optic chiasm?"], "contexual_behavior": ["Is there a region where increased autofluorescence could indicate the use of aldehyde-based chemicals or extended fixation?", "Is there a structure where enzymatic activity might be better preserved if milder chemicals and shorter processing times were used?", "Does the tissue appear to have lost the ability to retain in situ hybridization signals, potentially due to nucleic acid degradation from overexposure to fixatives?"], "functions": ["Are there visual indicators of immune cell infiltration or inflammatory markers within the eye tissue?", "Is there localization of specific proteins or biomarkers visible in the ocular specimen?", "Are there signs of biological processes such as apoptosis, cell proliferation, or tissue remodeling within the ocular tissue?"]}}, "colon": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify regions such as the ascending, transverse, descending, or sigmoid segments within the image?", "Is there a structure that appears adjacent to the small intestine or rectum?", "Can you see any anatomical features located near the kidneys or bladder?", "Does the image contain vessels that could correspond to the superior or inferior mesenteric arteries supplying a digestive organ?", "Is there evidence of innervation by the enteric nervous system or by fibers from the vagus or pelvic splanchnic nerves in any visible structure?", "Can you identify a region that is continuous with the rectum at its terminal end?", "Is there a visible junction where the ileum meets a larger tubular structure, possibly involving the ileocecal valve?", "Does the image show a wall composed of multiple layers such as mucosa, submucosa, muscularis propria, and serosa?", "Are there lymphatic structures present, such as mesenteric or colic lymph nodes, associated with a tubular digestive organ?", "Can you identify anatomical boundaries such as the ileocecal junction or rectosigmoid junction in the image?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for absorbing water from digested food?", "Can you identify an area involved in regulating electrolyte levels, such as sodium and chloride absorption?", "Is there a region where undigested carbohydrates might be fermented by anaerobic bacteria?", "Does the image contain a structure that compacts waste material and stores it until elimination?", "Can you see evidence of an environment that supports the proliferation of beneficial gut microbiota?", "Is there a visible area where vitamins like vitamin K and B vitamins could be absorbed after being synthesized by resident bacteria?", "Does the image show a structure that propels fecal matter toward the rectum for excretion?", "Can you identify a region involved in maintaining fluid balance through water and electrolyte reabsorption?", "Is there a structure present that contributes to immune defense via gut-associated lymphoid tissue or antimicrobial peptide production?"]}, "no_questions": {"contexual_properties": ["Is there a visible region where the base of the cranial cavity is open and the brain tissue is not present?", "Does the image show a cranial structure where the brain is absent?", "Can you identify an area that exposes the internal surface of the skull?"], "properties": ["Can you identify bony features at the base of the skull that are exposed due to the removal of neural tissue?", "Does the image display openings or foramina at the base of the cranial cavity?", "Is there evidence of an anatomical region that would normally support or house the brain but is now empty?"], "relational": ["Does the image reveal cavities like the cranial cavity, paranasal sinuses, or orbits?", "Can you identify bony structures such as the occipital, sphenoid, temporal, ethmoid, or frontal bones?", "Can you observe the contours of the anterior, middle, or posterior cranial fossae?"], "contexual_behavior": ["Is there visual evidence of altered passage of air or fluids between cranial and extracranial spaces, suggesting compromised natural barriers?", "Can you observe features that would increase the risk of cerebrospinal fluid leakage, such as an opened dura mater or skull base defect?", "Does the image reveal compromised structural support for cranial nerves, such as exposed or damaged bony foramina?"], "functions": ["Does the image provide access to bony and soft tissue features that can be correlated with neurological functions?", "Is there a clear demonstration of spatial relationships and possible surgical corridors at the base of the skull?", "Can you identify a view that allows direct visualization of cranial nerves and major blood vessels traversing the skull base?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": ["Is there evidence of a structure on the left side of the uterus that is not visible due to the presence of a hemorrhagic inflammatory mass?", "Does the image show a mass that obscures anatomical features typically found adjacent to the left side of the uterus?", "Can you identify a hemorrhagic inflammatory mass that prevents visualization of structures normally present near the left uterine region?"], "properties": ["Can you identify an area to the left of the uterus where the normal appearance of a tube and ovary is not visible due to an overlying mass?", "Does the image show evidence of inflammation and hemorrhage in the adnexal region adjacent to the uterus?", "Is there a mass in the left adnexal area that prevents visualization of typical reproductive structures?"], "relational": ["Does the image show a hemorrhagic inflammatory mass involving tissues such as blood clot or inflammatory exudate near the uterus?", "Can you identify a region adjacent to the uterus where the broad ligament would normally connect to laterally positioned structures?", "Does the image suggest the absence or obscuration of structures that would typically receive blood supply from the ovarian or uterine arteries on the left side of the uterus?"], "contexual_behavior": ["Can you identify a region where the normal appearance of a tube and an ovary to the left of the uterus is not visible due to a hemorrhagic inflammatory process?", "Is there evidence in the image of a mass that obscures a tubular structure and an adjacent organ on one side of the uterus?", "Is there a mass present that prevents visualization of the left-sided adnexal structures next to the uterus?"], "functions": ["Is there a structure on the left side of the uterus whose appearance suggests disruption of ovulation or blocked egg transport?", "Is there evidence of compromised venous or lymphatic drainage, reduced arterial supply, or edema affecting the left tube and ovary?", "Does the image reveal tissue changes in the left adnexa that might interfere with follicular development or ovulation?"]}}, "colon adenocarcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a malignant process affecting the gastrointestinal system?", "Is there evidence of abnormal tissue involving regions such as the ascending, transverse, descending, or sigmoid parts of a large intestinal structure?", "Can you identify a lesion that invades multiple layers of the colon wall, such as the mucosa, submucosa, muscularis propria, or serosa?", "Is there a mass adjacent to structures like the small intestine, peritoneum, or retroperitoneal tissues?", "Does the image reveal involvement of lymph nodes such as mesenteric, paracolic, or pericolic nodes near a colonic region?", "Can you see blood vessels, specifically branches of the superior or inferior mesenteric arteries, supplying an abnormal area?", "Is there evidence of a tumor arising from the epithelial lining within the gastrointestinal tract?", "Does the image suggest possible direct extension of a mass into organs like the bladder, small intestine, or abdominal wall?", "Can you identify features consistent with lymphatic or hematogenous spread from a colonic lesion?", "Is there a structure whose relationship to the colon wall layers can be visually assessed for invasion or disruption?"], "contexual_behavior": [], "functions": ["Does the image show a region with evidence of uncontrolled cellular growth or invasion into surrounding tissues?", "Can you identify an area where the normal tissue architecture appears disrupted, suggesting local invasion or matrix degradation?", "Is there a structure that appears to obstruct the lumen or disrupt the normal mucosal surface?", "Does the image display features consistent with new blood vessel formation, possibly indicating angiogenesis?", "Can you see evidence of immune cell infiltration or regions where immune surveillance might be evaded?", "Is there any indication of cells spreading beyond their original location, suggesting metastatic potential or epithelial-mesenchymal transition?", "Does the image show abnormal cellular arrangements that could be associated with altered signaling pathways such as Wnt/\u03b2-catenin or KRAS activation?", "Can you identify areas with increased inflammatory cell presence or signs of cytokine release?", "Is there visible damage to the mucosal surface that could impair nutrient absorption?", "Does the image contain regions where cells appear resistant to programmed cell death, such as densely packed viable cells despite abnormal architecture?", "Are there signs of extracellular matrix remodeling, such as altered stromal composition or increased matrix degradation?", "Can you see evidence of changes in the tumor microenvironment, such as fibrosis or altered immune cell distribution?", "Is there an area where cell proliferation appears abnormal, possibly due to dysregulated cell cycle checkpoints?", "Does the image show loss of epithelial barrier integrity, such as disrupted tight junctions or increased permeability?", "Can you identify interactions between abnormal epithelial cells and surrounding stromal or immune cells, such as activated fibroblasts or recruited macrophages?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image include tissue that appears pale pink to whitish, possibly due to vascularity and connective tissue components?", "Can you identify an area where fat content might constitute up to 50%, especially in subcutaneous regions?", "Can you see a tissue layer that would maintain a temperature close to core body temperature, approximately 36\u201337\u00b0C?"], "relational": ["Does the image show a region that is part of the integumentary, digestive, or respiratory system and contains a supportive layer beneath an epithelial surface?", "Does the image contain features such as extracellular matrix, blood vessels, or nerve fibers supporting a layer beneath an epithelium?", "Can you identify a tissue interface in the skin, oral cavity, or gastrointestinal tract where support and nourishment are provided to an overlying layer?"], "contexual_behavior": ["Is there visible accumulation of fluid or swelling in deeper tissues, suggesting edema following vascular damage?", "Does the image show evidence of structures that have lost support for overlying layers, possibly due to trauma or tissue damage?", "Is there a region where increased cellular activity or matrix synthesis suggests a response to injury or wound healing?"], "functions": ["Is there a structure in the image that provides physical support or cushioning to the layers above it?", "Can you identify a region that appears to nourish adjacent tissues, possibly through visible blood vessels?", "Does the image reveal a structure that connects or anchors different tissue layers, contributing to overall stability?"]}}, "lymphangiomatosis": {"yes_questions": {"contexual_properties": ["Does the image show any abnormal proliferation of lymphatic vessels?", "Can you identify regions with diffuse or multifocal lymphatic channel involvement?", "Is there evidence of a condition affecting multiple organs or tissues through lymphatic vessel overgrowth?", "Does the image reveal any widespread lymphatic abnormalities that could indicate a systemic disorder?"], "properties": ["Does the image show multiple masses that are diffuse throughout the tissue?", "Can you identify lesions that range in size from a few millimeters to several centimeters?", "Are there structures that appear translucent, pale, or yellowish in color?", "Is there evidence of tissue composed predominantly of lymphatic vessels and connective tissue?", "Do any of the visible lesions seem to contain fluid volumes in the milliliter to tens of milliliters range?", "Can you see masses that might have a low protein content in their fluid, similar to lymph?", "Are there areas with a cellular makeup including lymphatic endothelial cells, fibroblasts, or occasional inflammatory cells?", "Does the affected tissue appear to have lower density than surrounding normal tissue, possibly due to fluid-filled spaces?", "Are any of the lesions irregular or multiloculated in shape?", "Can you identify structures that might have a high water content, consistent with serous fluid?", "Is there evidence of tissue with low lipid content, except in regions that could contain chylous fluid?", "Do any of the lesions appear to have a soft, spongy, or cystic texture?", "Are there masses that seem to grow slowly and progressively over time?", "Can you see lesions that would be expected to have a neutral to slightly alkaline pH in their fluid?", "Are there areas with low vascularity, suggesting the presence of lymphatic rather than blood vessels?"], "relational": ["Does the image show evidence of abnormal changes within the lymphatic system?", "Can you identify any alterations in lymphatic vessels or connective tissue?", "Is there a visible abnormality affecting the respiratory or skeletal systems?", "Does the image reveal involvement of anatomical regions such as the thorax, abdomen, bones, or skin?", "Are there signs of altered lymphatic capillaries or collecting lymphatic vessels?", "Can you see any lesions present in the pleural or peritoneal cavity, or the mediastinum?", "Is there evidence of abnormal proliferation within lymphatic structures?", "Does the image show changes in organs like the lungs, liver, spleen, or bones?", "Are there visible abnormalities in tissues adjacent to blood vessels, nerves, or muscles?", "Can you identify any interactions between affected tissues and the circulatory, immune, or musculoskeletal systems?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal proliferation of vessels that could indicate multi-organ dysfunction?", "Can you identify any signs of vessel obstruction or malformation that might disrupt normal drainage?", "Is there visible fluid retention or swelling in tissues suggestive of impaired lymphatic function?", "Does the image display features consistent with impaired migration of immune cells due to blocked lymphatic pathways?", "Are there indications of excessive vessel growth or structural abnormalities affecting normal vessel function?", "Can you observe tissue swelling or edema that could result from poor lymphatic drainage?", "Is there evidence of impaired absorption of dietary fats, such as changes in intestinal structures responsible for chylomicron transport?", "Does the image suggest reduced clearance of waste products from tissues, possibly due to lymphatic dysfunction?", "Are there signs that immune surveillance might be decreased, such as limited movement of antigen-presenting cells or lymphocytes?", "Can you see features that would indicate increased interstitial fluid pressure resulting from disrupted drainage and fluid accumulation?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a region in the image that appears wedge-shaped or triangular, suggesting a pattern related to vascular supply?", "Does the image contain an area that could be measured in centimeters and varies in size from a few millimeters to several centimeters?", "Is there a zone with decreased tissue density compared to the surrounding area?"], "relational": ["Does the image show evidence of tissue disruption or loss of normal architecture in regions such as the myocardium or brain tissue?", "Is there visual evidence of involvement of the cardiovascular, nervous, renal, or respiratory systems in a pathological process?", "Does the image show signs of edema, inflammation, reactive gliosis, or fibrosis adjacent to an area of tissue damage?"], "contexual_behavior": [], "functions": ["Is there a visible area where normal biological processes such as oxygen delivery or nutrient exchange might be impaired?", "Does the image contain tissue that appears to have been replaced by non-functional scar tissue?", "Is there evidence of impaired tissue perfusion that could negatively affect the circulatory system or increase the risk of thrombosis?"]}}, "alpha smooth muscle actin immunohistochemical": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show cells with moderate to strong staining intensity?", "Can you identify regions where positive cells are present based on staining?", "Is there a staining pattern that primarily highlights smooth muscle cells or myofibroblasts?", "Does the staining appear localized within the cytoplasm of certain cells?", "Can you observe a brown coloration in the tissue, suggesting the use of DAB chromogen?", "Is there evidence of a staining protocol that would require an antibody concentration in the range of 1 to 5 micrograms per milliliter?", "Does the image suggest detection of a protein with an approximate molecular weight of 42 kilodaltons?", "Is there any indication that the staining procedure was performed at a pH between 7.2 and 7.6?", "Can you infer that the incubation time for the staining was between 30 and 60 minutes at room temperature?", "Does the image suggest that the staining was carried out at a temperature of about 20 to 25 degrees Celsius?"], "relational": ["Does the image show staining that highlights structures within blood vessels or the gastrointestinal tract?", "Can you identify regions in the image where smooth muscle cells or myofibroblasts are specifically marked?", "Is there evidence of staining in anatomical features such as vascular walls or the muscularis layer?", "Does the image display highlighted regions corresponding to the cardiovascular, respiratory, or digestive systems?", "Can you see areas where actin filaments in smooth muscle tissue are visually accentuated?", "Are there connective tissue components such as myofibroblastic stroma or fibrous septa that appear distinctly stained?", "Does the image reveal the architecture of vessel walls, including the tunica media or vascular smooth muscle layers?", "Can you identify organ systems in the image that contain cells positive for this type of staining, such as the reproductive or genitourinary systems?", "Are anatomical boundaries like muscularis mucosae or tumor margins visually defined by the staining pattern?", "Does the image show histological structures such as smooth muscle bundles or pericytic layers that are specifically highlighted?"], "contexual_behavior": [], "functions": ["Does the image show regions where contractile force is generated within smooth muscle or myofibroblast-containing tissues?", "Can you identify areas where actin-myosin interactions might be enabling muscle contraction?", "Is there evidence of smooth muscle differentiation or myofibroblast activation in the tissue?", "Does the image highlight regions suggestive of tissue repair or fibrosis due to myofibroblast activity?", "Are there areas indicating wound contraction or extracellular matrix deposition as part of tissue remodeling?", "Can you see specific labeling of contractile filaments in vascular smooth muscle cells within blood vessels?", "Does the staining pattern reveal cells engaged in contractile or reparative processes associated with tissue remodeling?", "Are there features consistent with myofibroblast-mediated wound closure?", "Can you identify regions where regulation of vascular tone, such as vasoconstriction or vasodilation, might be occurring?", "Does the image provide visual evidence for the assessment of fibrosis through the distribution of activated myofibroblasts?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify structures that would remain stable across a pH range of 4 to 10?", "Are there structures present that are denser than the surrounding cytoplasm?", "Does the image show any intracellular structures that are between 0.2 and 2 micrometers in diameter?"], "relational": ["Is there evidence of intranuclear or cytoplasmic inclusions within the depicted cells?", "Does the image contain structures found in nervous tissue, liver tissue, or epithelial tissue?", "Does the image display subcellular objects within the cytoplasmic matrix or nuclear matrix?"], "contexual_behavior": ["Can you identify regions where impaired autophagy or lysosomal dysfunction might reduce the clearance of aggregated material?", "Can you observe a reduction in the size of aggregates, possibly indicating successful protein refolding or chaperone activity?", "Can you identify features that might indicate protein overproduction or acute infection within cells?"], "functions": ["Does the image show intracellular structures that could be sites of protein aggregation?", "Does the image show any intracellular bodies that may impair cell function if present in excess?", "Can you see any features that might reflect the cell's response to pathological conditions or stress?"]}}, "typical histology": {"yes_questions": {"contexual_properties": ["Does the image show evidence of increased cell size that might indicate hypertrophy or cellular adaptation?", "Can you identify areas with reduced cell density suggestive of tissue atrophy or cell loss?", "Is there a region with abnormal staining patterns that could reflect pathological changes or altered cellular components?", "Does the image display increased extracellular matrix consistent with fibrosis or tissue remodeling?", "Can you see a loss of tissue organization that might be associated with neoplasia or severe inflammation?", "Is there evidence of enlarged nuclei that could indicate dysplasia or malignant transformation?", "Does the tissue architecture appear altered in a way that suggests structural disruption or chronic injury?", "Are there increased mitotic figures visible, possibly indicating rapid proliferation or the presence of tumors?", "Can you observe cells with decreased cytoplasmic volume, as seen in atrophy or cell degeneration?", "Is there increased fibrosis apparent, which could be due to chronic inflammation or scarring?", "Do you notice changes in tissue color that might result from pigment deposition or altered blood content?", "Are there increased numbers of inflammatory cells, suggesting acute or chronic inflammatory responses?", "Does the image show signs of tissue atrophy that could be due to decreased workload or denervation?", "Is there evidence of tissue hypertrophy, possibly in response to increased functional demand or hormonal stimulation?", "Can you identify increased vascularization that might indicate angiogenesis or tissue repair?", "Are there abnormal cell shapes present, which could be associated with dysplasia or certain genetic disorders?", "Do you see a loss of normal layering that might suggest epithelial dysplasia or invasive carcinoma?", "Is there increased pigment deposition, as might be seen in conditions like hemosiderosis or lipofuscinosis?", "Can you observe tissue edema that could result from inflammation or vascular leakage?", "Does the tissue thickness appear altered, possibly due to hyperplasia or atrophy?"], "properties": ["Does the image show cells arranged in organized layers or sheets?", "Can you identify structures that could be epithelial, connective tissue, muscle, or nerve cells?", "Are the majority of cells in the image between 10 and 30 micrometers in diameter?", "Do the cells exhibit round, polygonal, or elongated shapes depending on their location or function?", "Is there evidence of basophilic nuclei and eosinophilic cytoplasm after standard staining?", "Can you observe a nuclear-to-cytoplasmic ratio of approximately 1:3 to 1:4 in the cells?", "Does the image display a moderate and uniform distribution of cells throughout the tissue?", "Is there a clear or lightly stained extracellular matrix with visible fibers such as collagen?", "Do the tissue sections appear pink and purple, consistent with hematoxylin and eosin staining?", "Are the tissue sections cut at a thickness of about 4 to 6 micrometers?", "Can you see regions with a single cell layer as well as areas with multiple layers?", "Are prominent organelles such as nuclei, nucleoli, and mitochondria visible within the cells?", "Is there a variable but significant proportion of connective tissue providing structural support?", "Does the image show a low mitotic index, with less than 1% of cells undergoing mitosis?", "Are the nuclei within the cells approximately 5 to 10 micrometers in diameter?"], "relational": ["Does the image display tissue organization characteristic of the digestive, respiratory, nervous, or cardiovascular systems?", "Can you identify regions composed of epithelial, connective, muscle, or nervous tissue?", "Are there visible cells such as epithelial cells, fibroblasts, muscle cells, or neurons?", "Does the image show anatomical structures like glands, blood vessels, nerves, or basement membranes?", "Is there evidence of organs such as the liver, kidney, heart, lung, or skin being examined?", "Can you distinguish layers such as mucosa, submucosa, muscularis, or serosa within the tissue?", "Does the tissue exhibit distinct layers, functional units, or specific cellular arrangements?", "Are features like cell shape, layering, or specialized structures apparent in the sample?", "Can you identify anatomical landmarks such as a basement membrane, lumen, capsule, or septa?", "Is there connective tissue present, indicated by collagen fibers, elastic fibers, ground substance, or extracellular matrix?"], "contexual_behavior": ["Does the image show evidence of tissue where immune cell infiltration or edema has disrupted the normal architecture, suggesting an inflammatory response?", "Can you identify areas where cellular organization appears lost, possibly due to oxygen deprivation leading to swelling and disarray?", "Is there a region where epithelial integrity or tight junctions seem compromised, indicating impaired barrier function in response to infection?", "Does the tissue display signs of chronic damage or fibrosis that might inhibit normal cell proliferation and repair, suggesting a loss of regenerative capacity?", "Can you observe features such as cellular senescence or mitochondrial dysfunction that would indicate reduced metabolic activity, as seen during aging?", "Is there evidence of altered receptor expression or disrupted intracellular pathways, pointing to abnormal cell signaling in a disease state?", "Does the image reveal villous atrophy or mucosal thinning that could impair nutrient absorption, as might occur in malnutrition?", "Are there signs of extracellular matrix remodeling or atrophy that would indicate structural changes due to chronic stress?", "Can you see damage to excretory cells or disrupted clearance mechanisms, suggesting impaired waste removal following toxin exposure?", "Is there evidence of immune-mediated tissue destruction that disrupts physiological balance, indicating a failure to maintain homeostasis in an autoimmune condition?"], "functions": ["Does the image show tissue with a well-organized cellular architecture that would support healthy organ function?", "Can you identify a region where cells and extracellular matrix appear coordinated, suggesting support for vital physiological processes?", "Is there evidence of preserved structural integrity that would enable effective tissue repair and regeneration?", "Does the arrangement of cells indicate precise organization and the presence of specialized junctions for cell communication?", "Can you observe features such as organized vascular structures or cell layers that would facilitate optimal nutrient and waste exchange?", "Is there a visible structural niche that could support immune cell surveillance within the tissue?", "Does the tissue display a balanced composition of cell types and extracellular components, suggesting maintenance of integrity and function?", "Can you see signs of balanced cell turnover or a stable microenvironment that would indicate tissue homeostasis?", "Is there evidence of structural cues or microenvironments that could guide cell movement and differentiation within the tissue?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Are there visible interactions between affected lymphatic structures and the circulatory or endocrine systems?", "Can you identify any structures that resemble enlarged lymph nodes?", "Can you identify any features suggesting the presence of malignant lymphocytes or abnormal B, T, or NK cells?"], "contexual_behavior": [], "functions": ["Can you detect activation of signaling pathways such as NF-\u03baB, JAK/STAT, or PI3K/AKT in lymphocyte populations?", "Can you detect features suggesting a reduction in effective immune cell populations or compromised immune responses?", "Does the image show evidence of a process characterized by uncontrolled cell growth and resistance to programmed cell death?"]}}}
[ { "answer": "hyperplasia without atypia", "extracted_concepts": [ "cellular atypia", "glandular crowding", "hyperplasia without atypia" ], "question": "what is seen as glandular crowding and cellular atypia?" }, { "answer": "glandular crowding and cellular atypia", "extracted_concepts": [ "cellular atypia", "glandular crowding", "hyperplasia with atypia" ], "question": "what is hyperplasia with atypia seen as?" }, { "answer": "yes", "extracted_concepts": [ "cellular atypia", "glandular crowding", "hyperplasia with atypia" ], "question": "is hyperplasia with atypia seen as glandular crowding and cellular atypia?" }, { "answer": "no", "extracted_concepts": [ "cellular atypia", "inclusion-like nucleoli", "abundant cytoplasm", "binucleate reed-sternberg cell", "glandular crowding" ], "question": "is a binucleate reed-sternberg cell with large, inclusion-like nucleoli and abundant cytoplasm seen as glandular crowding and cellular atypia?" } ]	["cellular atypia", "inclusion-like nucleoli", "hyperplasia without atypia", "hyperplasia with atypia", "abundant cytoplasm", "binucleate reed-sternberg cell", "glandular crowding"]	{"cellular atypia": {"yes_questions": {"contexual_properties": ["Does the image show features that become more severe as tissue progresses from benign to malignant lesions?", "Can you identify changes that are more pronounced in the presence of chronic inflammation or after exposure to chemical agents?", "Is there evidence of increased nuclear size in areas where cells appear to be proliferating abnormally?", "Does the image reveal regions with a higher nuclear-to-cytoplasmic ratio, as seen in high-grade dysplasia or malignant tumors?", "Are there cells displaying abnormal chromatin patterns, which might indicate neoplastic transformation?", "Can you observe increased pleomorphism in tissues that could suggest advanced dysplasia or malignancy?", "Is there a higher frequency of abnormal cells in regions that resemble tumor biopsies or precancerous lesions?", "Do you see irregular cell shapes in areas that might correspond to dysplastic or cancerous tissue?", "Are there more mitotic figures present in regions where cell proliferation appears to be rapid or uncontrolled?", "Can you identify cells with abnormal nucleoli, as might be seen in neoplastic or malignant conditions?", "Is there evidence of cellular changes that are more apparent in areas affected by chronic or persistent inflammation?", "Do you notice alterations in cytoplasmic staining patterns that could be due to changes in protein synthesis in dysplastic or malignant cells?", "Are there regions where cell size varies more than usual, possibly indicating neoplastic progression?", "Can you detect features that are especially prominent in high-grade tumors or malignant neoplasms?", "Is there an increase in hyperchromatic nuclei in areas where cells might have abnormal DNA content or malignancy?"], "properties": ["Does the image show cells with nuclei that appear larger than usual?", "Can you identify areas where the nuclear contours are irregular or angulated?", "Is there evidence of cells with an increased ratio of nuclear size to cytoplasmic volume?", "Do you observe a population of cells with greater size variability compared to normal tissue?", "Are there nuclei that appear oval, angulated, or bizarre in shape?", "Can you see cells where the nuclei occupy a disproportionately large area relative to the cytoplasm?", "Is there a region where the chromatin appears coarse, clumped, or unevenly distributed within the nuclei?", "Do any cells display prominent or enlarged nucleoli?", "Are there nuclei that stain more intensely than others, suggesting hyperchromasia?", "Can you find cells with marked variation in nuclear size and shape within the same field?", "Is there evidence of cytoplasm that appears scant, irregular, or vacuolated?", "Do you observe an increased number of mitotic figures, possibly with atypical forms?", "Are there nuclei with irregular, thickened, or indented nuclear membranes?", "Can you identify cells with indistinct or poorly defined borders?", "Is there a region where nuclear staining is particularly extensive or intense?", "Do you notice areas with higher cell density than typically seen in normal tissue?", "Are there cells whose orientation appears disorganized or lacking normal polarity?"], "relational": ["Does the image show any tissue where the normal architecture appears disorganized, such as loss of polarity or abnormal stratification?", "Can you identify cells with features like nuclear pleomorphism, hyperchromasia, or an increased nuclear-cytoplasmic ratio?", "Is there evidence of lesions such as dysplasia or carcinoma in situ within the depicted tissue?", "Does the image contain structures that could be classified as tumors or precancerous lesions?", "Are there cells with irregular nuclear shapes, enlarged nuclei, or abnormal mitoses visible in the sample?", "Can you see any abnormal changes in epithelial, glandular, or squamous cells?", "Is there a region in the image that might represent a dysplastic lesion in tissues such as the cervix, skin, or respiratory tract?", "Does the image show any part of the reproductive, respiratory, integumentary, or digestive systems where abnormal cellular features are present?", "Are there visual indications of atypical cells in organs like the lung, breast, or prostate?", "Can you identify connective, epithelial, or hematopoietic tissue areas with abnormal cellular morphology?"], "contexual_behavior": ["Does the image show evidence of increased abnormal cellular features in areas of chronic inflammation?", "Can you identify cells with pronounced morphological or nuclear changes that might be associated with carcinogen exposure?", "Is there a region where abnormal cell features appear reduced, possibly indicating removal of a pathological stimulus?", "Does the image display cells with worsening morphological and nuclear abnormalities suggestive of malignant transformation?", "Can you see areas where abnormal cell morphology appears to improve, potentially following effective therapy?", "Is there evidence of cellular and nuclear changes in regions that could be affected by viral infection?", "Does the image contain tissue with accumulating dysplastic changes characteristic of precancerous lesions?", "Are there cells showing progressive abnormal features in regions that might be experiencing persistent oxidative stress?", "Can you observe restoration of normal tissue architecture and cell morphology, suggesting tissue healing?", "Is there an area where abnormal cellular features are more prominent, possibly due to hypoxic conditions?", "Does the image show increased abnormal cell growth or features in a context that could indicate an immunocompromised state?", "Are there regions where altered cell proliferation or differentiation might be linked to hormonal imbalance?", "Can you identify cells with intensified abnormal features that could be related to genetic mutations affecting cell cycle or DNA repair?", "Is there evidence of reduced abnormal cell features in areas where toxic exposure may have ceased?", "Does the image reveal fluctuations in abnormal cellular morphology across different stages of tumor development?"], "functions": ["Does the image show evidence of tissue dysfunction, such as disrupted organization or abnormal cellular arrangement?", "Can you identify areas where there is an increased risk of neoplastic transformation or early signs of tumor progression?", "Is there a region displaying abnormal cell growth patterns, such as loss of polarity or impaired communication between cells?", "Does the image reveal structural disruption or compromised integrity within the tissue?", "Can you observe signs of uncontrolled proliferation, such as increased mitotic figures or irregular cell division?", "Is there visual evidence of cell cycle dysregulation, such as clusters of cells at different stages of division or checkpoint failure?", "Do you see cells that appear less specialized or exhibit features of dedifferentiation compared to surrounding tissue?", "Are there indications of genetic instability or features commonly associated with carcinogenesis?", "Does the tissue display signs of impaired stress response or increased vulnerability to damage?", "Can you identify areas where abnormal cells seem resistant to apoptosis or persist despite signs of cellular stress?", "Is there evidence of aberrant signaling, such as cells responding inappropriately to growth factors or environmental cues?", "Does the image show architectural distortion, such as loss of normal cell arrangement or disorganized tissue structure?", "Are there regions where altered antigen expression might suggest immune evasion by abnormal cells?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show cell types like neurons or muscle cells distributed across various regions?", "Are major body parts such as the trunk, upper limbs, or lower limbs present?", "Are there visible anatomical structures that connect different regions, such as blood vessels or nerves?"], "contexual_behavior": [], "functions": ["Is there evidence of fluid or electrolyte homeostasis, possibly involving renal structures?", "Can you identify features associated with immune surveillance or inflammation in response to infection?", "Can you see indications of thermoregulation, such as sweating or shivering?"]}}, "inclusion-like nucleoli": {"yes_questions": {"contexual_properties": ["Does the image show nuclear structures that appear enlarged in the context of cellular stress, viral infection, or neoplastic transformation?", "Can you identify nuclear features that are reduced in size during cellular quiescence, apoptosis, or after stress resolution?", "Are there nuclear bodies with altered shapes that might indicate changes in nucleolar function, oncogenic signaling, or toxin exposure?", "Is there evidence of prominent nuclear structures in actively proliferating cells, malignancy, or following nucleolar hypertrophy?", "Do any nuclear features appear less visible in areas showing cellular differentiation, senescence, or after therapy response?", "Can you observe variation in the number of nuclear bodies within the nucleus, possibly reflecting cell cycle progression, nucleolar fusion, or fragmentation?", "Are there nuclear structures with unusual staining properties that could suggest changes in protein or RNA content, or fixation artifacts?", "Do you see nuclear inclusions that might indicate accumulation of abnormal proteins, as seen in neurodegenerative diseases, certain viral infections, or protein aggregation disorders?", "Are there nuclear features with irregular borders, suggestive of dysplasia, malignancy, or nucleolar remodeling?", "Can you identify fragmented nuclear structures that could be associated with apoptosis, mitotic catastrophe, or severe cellular injury?", "Are there nuclear bodies with increased density, possibly reflecting enhanced ribosomal biogenesis, oncogenic activity, or nucleolar stress?", "Do any nuclear inclusions appear vacuolated, as might occur in degenerative conditions, autophagy, or after toxic injury?", "Is there evidence of altered nuclear ultrastructure that could be linked to genetic disorders affecting nucleolar proteins, viral infections, or chemotherapy exposure?", "Are there nuclear features that appear eosinophilic, potentially due to increased protein content, specific staining protocols, or pathological states?", "Can you observe loss of granular appearance in nuclear bodies, which may indicate nucleolar maturation defects, protein aggregation, or drug exposure?"], "properties": ["Does the image show any round or oval structures within the nucleus that are approximately 1 to 5 micrometers in diameter?", "Can you identify one or more prominent, sharply defined, and intensely stained objects inside the nucleus?", "Are there nuclear structures that appear eosinophilic or intensely basophilic under the staining method used?", "Do you observe multiple small bodies (one to several) within a single nucleus?", "Is there evidence of granular or fibrillar texture within any nuclear substructure under high magnification?", "Can you see nuclear objects that appear denser than the surrounding nucleoplasm?", "Are there any nuclear components that might have a higher refractive index than the surrounding material (approximately 1.38 to 1.42)?", "Do any nuclear structures display marked granularity, suggesting the presence of dense ribonucleoprotein particles?", "Is there a visible nuclear feature that could indicate a high concentration of nucleic acids, such as ribosomal RNA?", "Can you detect nuclear objects that might be composed mainly of proteins like fibrillarin or nucleophosmin?", "Are there any nuclear structures that could contain abnormal inclusions or viral material?", "Do you observe distinct granular and fibrillar regions within any nuclear body?"], "relational": ["Does the image show cells with abnormal nucleolar morphology within their nuclei?", "Can you identify neoplastic or tumor cells that contain distinctive nuclear features?", "Is there evidence of nuclear abnormalities in certain epithelial cells present in the image?", "Are there structures within the nucleus that appear altered compared to typical nucleoli?", "Does the image display nuclear subdomains that include abnormal nucleolar variants?", "Can you see any cells in tumor tissue, liver, or lymphoid tissue that exhibit unusual nucleolar features?", "Are there visible nuclear structures closely associated with the nucleoplasm or nuclear envelope?", "Is there an indication of chromatin or nuclear matrix interacting with abnormal nucleolar structures?", "Can you identify nuclear organizer regions or Cajal bodies in proximity to altered nucleoli?", "Does the image contain cells with nucleolar components such as ribosomal RNA or nucleolar proteins arranged atypically?", "Are there features within the nucleus that suggest the presence of fibrillar centers in abnormal nucleoli?", "Can you see evidence of a pathological tissue context, such as a tumor microenvironment, where nuclear abnormalities are present?", "Is there a relationship between the nucleus and endoplasmic reticulum or nuclear pore complex visible in cells with abnormal nucleoli?"], "contexual_behavior": ["Does the image show a structure that increases ribosomal RNA synthesis during periods of rapid cell growth?", "Is there evidence of impaired ribosome assembly in response to cellular stress such as oxidative damage?", "Can you identify a feature that reduces its participation in cell cycle regulation when cells are quiescent or have DNA damage?", "Is there a structure that alters its function to facilitate viral replication or sequester viral proteins during viral infection?", "Does the image contain an object that decreases its involvement in protein synthesis under nutrient deprivation or starvation?", "Can you observe disrupted organization of a structure in the context of neurodegenerative diseases like Alzheimer's or Parkinson's?", "Is there a feature that enhances its activity during rapid cell proliferation, such as in embryogenesis or tumorigenesis?", "Does the image show a structure with reduced ability to sequester regulatory proteins during the DNA damage response?", "Can you see changes in nucleolar structure or function in response to oxidative stress?", "Is there evidence of loss of cell growth regulation in cancerous conditions due to oncogenic transformation?", "Does the image display increased stress response signaling during heat shock, such as upregulation of protective molecular pathways?", "Can you identify a structure that becomes less effective in supporting ribosome biogenesis during aging?", "Is there a feature that adjusts ribosomal RNA transcription and processing in response to hypoxia?", "Does the image show failure to support normal cellular homeostasis in the context of genetic disorders affecting nucleolar proteins or structure?", "Can you observe increased involvement in cellular senescence, such as promotion of senescence-associated secretory phenotypes?"], "functions": ["Does the image show a nuclear structure involved in ribosome biogenesis?", "Can you identify a region within the nucleus that serves as a site for rRNA transcription and processing?", "Is there evidence of a structure coordinating the maturation and modification of precursor rRNAs?", "Does the image contain a nuclear component that regulates gene expression by modulating rRNA gene transcription?", "Can you see a structure that might sequester transcription factors within the nucleus?", "Is there a nuclear region that appears altered in response to cellular stress or shows signs of nucleolar remodeling?", "Does the image reveal a scaffold within the nucleus that facilitates the assembly of ribonucleoprotein complexes?", "Can you identify a nuclear structure involved in controlling the synthesis of ribosomal components for cell proliferation?", "Is there evidence of a region within the nucleus adjusting its activity in response to metabolic changes?", "Does the image show a nuclear component that sequesters specific proteins or RNAs, potentially modulating their nuclear availability?", "Can you observe features suggesting dynamic remodeling or distinct subdomain organization within a nucleolar region?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion supplied by the ovarian artery or branches of the uterine artery?", "Is there a lesion located within the pelvic cavity?", "Can you identify a mass that appears to originate from ovarian stromal tissue?"], "contexual_behavior": [], "functions": ["Is there a mass that might be linked to irregularities in the menstrual cycle due to hormonal imbalance?", "Can you identify a mass that could reduce fertility by disrupting ovulation or damaging ovarian reserve?", "Is there a lesion that could induce premature or exaggerated development of secondary sexual characteristics due to excess estrogen?"]}}, "hyperplasia without atypia": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a tissue area where epithelial cells are proliferative but have uniform nuclei and are surrounded by abundant stroma?", "Can you identify a region where the tissue thickness appears moderately increased, approximately 1 to 2 millimeters?", "Is there an area with elevated cell density that does not reach the levels seen in atypical proliferative lesions?", "Do the nuclei in the epithelial cells appear small and regular, similar to those in normal endometrial tissue?", "Is there evidence of a mildly increased mitotic index, but not to the extent observed in malignant lesions?", "Can you see crowded glands that maintain non-complex architectural outlines?", "Are the epithelial cells characterized by moderate, eosinophilic cytoplasm without significant vacuolization?", "Does the gland-to-stroma ratio appear increased, while intervening stroma is still preserved and glands do not fuse or appear back-to-back?", "Is there a visible increase in epithelial proliferation without signs of cytological atypia?", "Do the nuclei display a fine, evenly distributed chromatin pattern without hyperchromasia?", "Can you observe two to three layers of epithelial cells, indicating mild stratification?", "Are the glands predominantly round to oval and only mildly irregular, without complex or cribriform patterns?", "Is secretory material generally absent or minimal in the tissue region under consideration?", "Does the affected tissue appear pink to light purple with hematoxylin and eosin staining?", "Is the cytoplasmic-to-nuclear ratio preserved and similar to that of normal endometrial cells?"], "relational": ["Does the image show a region within the endometrium, prostate, or breast that appears to have increased numbers of cells?", "Can you identify an area where epithelial or glandular cells are more numerous but maintain normal nuclear appearance?", "Is there a structure within the uterus, prostate gland, or mammary gland that shows preserved cellular architecture despite cell proliferation?", "Does the image contain glands or ducts, such as endometrial glands, prostatic acini, or mammary ducts, that appear enlarged without signs of nuclear atypia?", "Can you see a region in the endometrial lining, prostatic glands, or breast lobules with mild proliferation of the surrounding stroma?", "Is there evidence of increased glandular or epithelial layers adjacent to the basement membrane or connective tissue, but without abnormal nuclear features?", "Does the image show a histological section where the epithelial layer, glandular layer, or subepithelial stroma appears thickened but orderly?", "Can you identify an area within the reproductive, male genitourinary, or mammary system that demonstrates increased cell proliferation with absence of nuclear atypia?", "Is there a region where the stroma adjacent to proliferating glands or ducts shows edema or reactive changes?", "Does the image display preserved glandular or ductal architecture in a site commonly affected by hyperplastic processes, such as the endometrial lining or breast lobules?"], "contexual_behavior": ["Does the image show evidence of increased endometrial proliferation that could be associated with elevated estrogen levels?", "Is there a region where endometrial tissue appears expanded, possibly due to prolonged estrogen exposure without opposing progestin?", "Can you identify areas where the normal architecture of the endometrium seems disrupted, potentially as a result of chronic inflammation?", "Is there visual evidence of increased cellular turnover or regenerative activity following endometrial injury or repair?", "Does the image suggest reduced endometrial proliferation that might be consistent with postmenopausal status?", "Are there features indicating impaired growth regulation in the context of metabolic syndrome, such as persistent endometrial thickening?", "Can you observe endometrial tissue that appears not to regress despite the absence of an obvious proliferative stimulus, possibly due to persistent risk factors like obesity or chronic inflammation?", "Is there a visible decrease in endometrial proliferation that could be attributed to progestin therapy?", "Are there abnormal glandular or stromal responses in the endometrium that might reflect functional alterations during chronic inflammation?", "Does the image suggest increased persistence of endometrial proliferation that could be associated with an immunocompromised state?", "Is there evidence of decreased regression of endometrial tissue in the context of obesity-related hormonal imbalance?", "Can you see signs of regenerative proliferation in the endometrium following tissue injury?", "Are there areas where endometrial tissue fails to regress in the absence of atypical cellular features, possibly due to a persistent proliferative stimulus?", "Does the image reveal changes in endometrial growth dynamics that might be linked to perimenopausal hormonal fluctuations?"], "functions": ["Does the image show a tissue with an increased number of cells while maintaining normal cellular appearance and organization?", "Can you identify an area where tissue expansion is present without evidence of abnormal cell features?", "Is there a region where the architecture of the tissue appears preserved despite an apparent increase in cell density?", "Does the image reveal signs of enhanced tissue function or increased physiological capacity without disruption of normal structure?", "Can you see evidence of regeneration or repair characterized by additional cells that look morphologically normal?", "Is there a part of the tissue that appears enlarged or more massive, yet retains its normal function and structure?", "Does the image suggest elevated rates of cell division with cells that remain organized and structurally typical?", "Can you identify tissue that may be responding to hormonal or endocrine signals, resulting in increased cell numbers without signs of malignancy?", "Is there visual evidence of an adaptive response where tissue capacity is increased, but the overall integrity and organization are maintained?", "Does the tissue in the image appear to have undergone growth regulated by factors such as hormones or growth signals, with feedback mechanisms preventing excessive proliferation?", "Can you observe a shift toward cell growth over cell death, while overall tissue homeostasis and normal appearance are preserved?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image display limbs with noticeably increased circumference, potentially by 5 to 10 centimeters or more?", "Can you observe skin that appears swollen, stretched, and shiny due to extensive fluid retention?", "Does the image show a person with diffuse, symmetrical swelling throughout the subcutaneous tissues of the entire body?"], "relational": ["Can you see features suggesting impaired lymphatic drainage or lymphatic dysfunction?", "Is there visual evidence of increased capillary permeability or venous congestion in the depicted structures?", "Can you identify swelling that affects multiple regions such as the limbs, face, abdomen, or trunk?"], "contexual_behavior": [], "functions": ["Is there visible swelling that might be due to increased capillary permeability or fluid overload?", "Does the image show signs of lymphatic congestion or impaired drainage, such as extensive swelling that could indicate lymphedema?", "Is there evidence of increased distance between capillaries and cells that could impair nutrient or oxygen delivery?"]}}, "hyperplasia with atypia": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region where cells appear more densely packed than in surrounding tissue?", "Can you identify an area where the nuclei of cells are noticeably larger than those in adjacent normal tissue?", "Is there evidence of increased cell proliferation, such as a higher number of mitotic figures compared to normal regions?", "Does the image display cells with a higher nuclear-to-cytoplasmic ratio than expected for healthy tissue?", "Can you see nuclei that vary mildly to moderately in size and shape within a crowded cellular area?", "Is there a region where chromatin appears coarse and irregularly distributed within the nuclei?", "Do the cells in a particular area appear predominantly round or oval in shape?", "Is there an area where the cytoplasm of cells is moderate in amount and may show a slightly basophilic (bluish) appearance?", "Can you observe glandular structures that are crowded together or arranged in a complex architectural pattern?", "Is there a section where the epithelial layer is thicker than normal, with several cell layers visible?", "Are nucleoli more frequently visible and sometimes prominent within the nuclei in a specific region?", "Does the image contain cells or areas that exhibit moderate to strong staining intensity compared to the background?", "Can you find a region with marked cellular crowding, where cells are closely packed together?", "Is there evidence of increased stratification, with multiple layers of epithelial cells present in a localized area?"], "relational": ["Does the image show a region within the uterine lining, mammary gland, or prostatic tissue that appears structurally abnormal?", "Can you identify an area in the endometrium, breast ducts, or prostate glands with disrupted tissue architecture?", "Is there evidence of cellular disorganization or loss of polarity in the epithelial or glandular layers?", "Does the image contain cells with features such as increased nuclear-to-cytoplasmic ratio or nuclear atypia?", "Can you see regions where glandular outlines or tissue margins define the extent of an abnormal proliferation?", "Is there a visible distinction between affected epithelial or glandular cells and the adjacent stroma or basement membrane?", "Does the image show areas with architectural complexity or cellular pleomorphism compared to surrounding parenchyma?", "Can you identify a lesion that appears more complex than simple or benign proliferative changes?", "Is there a region where the basal layer or basement membrane is intact but the overlying cells appear atypical?", "Does the image display abnormal proliferation involving epithelial, glandular, or stromal cells within a defined anatomical boundary?"], "contexual_behavior": [], "functions": ["Does the image show an area with increased cell proliferation and abnormal cellular features?", "Can you identify a region where the normal tissue structure appears disrupted or disorganized?", "Is there evidence of excessive and disordered growth of cells with atypical morphology?", "Does the image reveal loss of normal tissue layering or increased cellular density?", "Can you see cells that appear to have lost their typical differentiation patterns?", "Is there a region that could represent a precancerous state due to abnormal cell growth?", "Does the image suggest disruption of cell cycle control or reduced apoptosis in a particular area?", "Can you identify tissue where normal regeneration seems impaired by uncoordinated cell growth?", "Is there a lesion that could serve as a precursor to neoplastic progression?", "Does the image show alterations in cellular signaling pathways related to growth, differentiation, or apoptosis?"]}, "no_questions": {"contexual_properties": ["Is there evidence of shrinkage or reduced volume in any area, suggestive of fibrosis, atelectasis, or surgical removal?", "Is there a structure that appears heavier or denser, which could indicate fluid, blood, or inflammatory exudate accumulation as seen in pneumonia or edema?", "Is there abnormal tissue growth or mass formation, which could indicate neoplastic processes or chronic inflammation?"], "properties": ["Does the image show a structure where the oxygen concentration in its air spaces would be around 13 to 14 percent under normal conditions?", "Is there a structure present that would have a soft, spongy, and elastic texture?", "Can you identify an organ where the right side has three lobes and the left side has two lobes?"], "relational": ["Can you see tissue types like alveolar tissue or smooth muscle within any structure?", "Does the image contain a structure that receives blood from pulmonary arteries or veins?", "Is there an object connected to airways such as the trachea or bronchi?"], "contexual_behavior": ["Does the image show a structure that appears to have lost elasticity, as might be seen in emphysema or chronic obstructive pulmonary disease?", "Does the image suggest impaired defense against airborne pathogens, such as might result from compromised mucociliary clearance or immunosuppression?", "Can you see signs of increased mucus production, which may occur during respiratory infection or inflammation?"], "functions": ["Does the image show an organ that filters small blood clots or air bubbles in the vascular network?", "Can you see evidence of a membrane that allows diffusion of gases such as oxygen and carbon dioxide?", "Can you identify a structure that contributes to vocalization by supplying airflow to the larynx?"]}}, "abundant cytoplasm": {"yes_questions": {"contexual_properties": ["Does the image show cells with increased volume suggestive of hypertrophy or active protein synthesis?", "Can you identify cells with granular cytoplasmic appearance, indicating increased secretory granules or lysosomes?", "Are there cells displaying vacuolated cytoplasm, as might be seen in hydropic change, lipid accumulation, or autophagy?", "Do any cells exhibit altered cytoplasmic color or staining, possibly due to metabolic changes or pigment accumulation?", "Is there evidence of lipid accumulation within the cytoplasm, as seen in metabolic disorders or fatty liver disease?", "Can you observe cells with increased basophilic staining, which could indicate elevated RNA or ribosome content?", "Are there cells with more eosinophilic cytoplasm, possibly due to increased protein content or mitochondrial proliferation?", "Do any cells appear to contain an increased number of organelles, suggesting high metabolic activity or differentiation?", "Is there evidence of cytoplasmic inclusions that could be related to viral infection, storage disease, or protein aggregation?", "Can you see cells with foamy or finely vacuolated cytoplasm, as might be found in foam cells or xanthomas?", "Are there cells with abnormal cytoplasmic staining patterns, potentially indicating necrosis, degeneration, or abnormal protein accumulation?", "Do you notice cells with reduced cytoplasmic volume, which could be due to atrophy or apoptosis?", "Is there a clearer appearance of the cytoplasm in some cells, possibly due to glycogen accumulation, hydropic change, or mucin production?", "Can you identify cells with increased cytoplasmic protein content, as seen during active secretion or synthesis of structural proteins?", "Are there signs of vacuolar degeneration in the cytoplasm, which might result from cellular injury, hypoxia, or toxic exposure?"], "properties": ["Is there a cell in the image where the area surrounding the nucleus occupies most of the cell body?", "Can you identify a region that appears pale or eosinophilic under light microscopy?", "Does the image show a cell with a large, lightly stained area relative to the nucleus?", "Is there evidence of a cell with visible organelles such as mitochondria, endoplasmic reticulum, Golgi apparatus, or ribosomes?", "Can you see a cell where the cytoplasmic region appears broad and organelle-rich?", "Is there a structure in the image that might have high water content, making up most of its mass?", "Does the cytoplasmic area of any cell appear granular, suggesting moderate to high granularity?", "Can you identify a cell where the cytoplasmic region could have a high protein concentration?", "Is there a cell with a cytoplasmic area that might contain glycogen granules or show low carbohydrate concentration?", "Does the image show a cell where the cytoplasmic region could be potassium-rich or maintain electrolyte balance?", "Is there a cell whose cytoplasmic region might have increased viscosity compared to water?", "Can you see a cell where the cytoplasmic density appears slightly greater than water?", "Is there evidence of a cell with elevated RNA content in the cytoplasmic region?", "Does the cytoplasmic area of any cell suggest high mitochondrial content, supporting increased metabolic activity?", "Is there a cell where the cytoplasmic region could have variable lipid content, as seen in certain cell types like hepatocytes or adipocytes?"], "relational": ["Does the image show cells that could be plasma cells, macrophages, hepatocytes, or epithelial cells?", "Can you identify tissue that might be liver tissue, glandular tissue, or connective tissue?", "Are there visible features suggesting the presence of organelles such as mitochondria, endoplasmic reticulum, Golgi apparatus, or ribosomes within the cells?", "Is there evidence of cell morphology that provides ample space for organelles and supports metabolic activity?", "Does the image contain anatomical structures like the liver, salivary glands, or lymph nodes?", "Can you see structures that are part of the digestive, immune, or endocrine systems?", "Are there cellular components such as cytosol, cytoskeletal elements, vesicles, or inclusions visible within the cells?", "Does the image show glandular epithelium, hematopoietic tissue, or reticuloendothelial tissue?"], "contexual_behavior": ["Is there evidence of a cellular region with decreased metabolic activity that could indicate exposure to hypoxia or oxidative damage?", "Can you identify a cell area showing signs of impaired protein synthesis, possibly due to limited amino acid availability from nutrient deprivation?", "Does the image display a region with increased organelle content, suggesting active cell growth or proliferation?", "Is there a cellular structure with reduced support for division, potentially as a result of toxic exposure affecting cytoskeletal or metabolic processes?", "Can you observe alterations in intracellular trafficking that might be associated with viral infection and hijacking of transport mechanisms?", "Is there a cell region with enhanced energy production, such as increased glycolysis or mitochondrial activity, indicative of rapid proliferation?", "Does the image show signs of disrupted organelle function or impaired metabolic regulation, which could reflect a failure to maintain homeostasis in degenerative disease?", "Can you see evidence of increased autophagic activity, such as cellular recycling, that might occur during starvation?", "Is there a region where buffering capacity appears reduced, possibly due to an acidic environment overwhelming pH regulation mechanisms?", "Do you observe features consistent with reduced waste removal, such as lysosomal dysfunction or decreased proteasome activity, in aging cells?", "Is there evidence of altered signal transduction, such as changes in second messenger pathways or protein localization, during inflammation?", "Can you identify increased storage of macromolecules, like glycogen or lipids, that could indicate a metabolic disorder?", "Does the image show a region failing to support normal cell function under hypoxic conditions, possibly due to impaired ATP production or altered redox balance?", "Is there evidence of enhanced detoxification, such as upregulation of antioxidant enzymes or glutathione synthesis, during oxidative stress?", "Can you observe reduced nutrient distribution, potentially due to impaired cytoskeletal transport or vesicle trafficking in a disease state?"], "functions": ["Does the image show a cell with features suggesting enhanced capacity for biosynthesis or metabolic activity?", "Is there a cell present that could accommodate a higher density of metabolic enzymes and substrates?", "Can you identify a cell where protein synthesis might be particularly active due to increased ribosome density?", "Does the image display a cell with sufficient space for optimal organelle maintenance and activity?", "Is there evidence of a cell with enough volume to support growth and division processes?", "Can you see a cell where intracellular transport of vesicles or organelles appears facilitated?", "Does the image include a cell that could serve as a reservoir for nutrients, ions, or macromolecules?", "Is there a cell present that might have an improved ability to respond to cellular stress due to cytoplasmic buffering capacity?", "Can you identify a cell with features supporting active secretion or exocytosis, such as space for vesicle trafficking?", "Does the image show a cell where energy production could be enhanced by the distribution of mitochondria?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure that appears denser than surrounding fat, possibly due to cellular infiltration or calcification?", "Can you find regions that might contain necrotic adipocytes or inflammatory cells?", "Are there areas that might have a slightly acidic environment due to inflammation and cellular breakdown?"], "relational": ["Does the image show any regions within adipose or subcutaneous tissue that appear abnormal?", "Does the image reveal regions where neutrophils or adipocytes are present in an inflammatory context?", "Are there areas surrounded by fibrous tissue, collagen fibers, or inflammatory stroma within fatty regions?"], "contexual_behavior": [], "functions": ["Can you identify areas that might be undergoing tissue remodeling due to the clearance of necrotic fat cells?", "Does the image show any regions where adipocyte death or localized tissue injury is apparent?", "Is there evidence of inflammatory mediator release, such as cytokines or chemokines, from damaged adipocytes or infiltrating immune cells?"]}}, "binucleate reed-sternberg cell": {"yes_questions": {"contexual_properties": ["Does the image show a cell that appears larger during active proliferation or in response to cytokine stimulation, as seen in Hodgkin lymphoma?", "Can you identify a cell that decreases in size after exposure to cytotoxic therapy or during apoptosis?", "Is there a cell exhibiting changes in shape that might indicate mitosis or microenvironmental stress?", "Does the image contain a cell with abnormal nuclear features suggestive of malignant transformation or advanced Hodgkin lymphoma?", "Can you see a cell with increased cytoplasmic volume, possibly due to activation or accumulation of organelles?", "Is there a cell displaying prominent nucleoli, which could indicate high transcriptional activity or increased ribosome production?", "Does any cell in the image show variable staining characteristics that might result from different histological stains or pathological changes?", "Can you identify a cell with inclusion bodies, potentially due to viral infection or metabolic disturbances?", "Is there evidence of altered chromatin patterns in any cell, possibly reflecting neoplastic progression or epigenetic modification?", "Does the image show a cell with cytoplasmic vacuolization, which could be a sign of degeneration or toxin exposure?", "Can you find a cell with more than two nuclei, suggesting abnormal mitosis or cell fusion events?", "Is there a cell that appears to have changed membrane composition, perhaps in response to activation signals or malignant transformation?", "Does the image reveal a cell with increased mitotic figures, indicating rapid proliferation or aggressive disease?", "Can you see a cell that is more eosinophilic, possibly due to increased cytoplasmic protein content or specific staining procedures?", "Is there a cell displaying changes in surface marker expression, which might reflect an immunophenotypic shift or influence from the tumor microenvironment?", "Does the image contain a cell with cytoplasmic granules, potentially associated with activation or certain pathological states?", "Can you identify a cell that appears more fragile, possibly as a result of apoptosis or exposure to chemotherapeutic agents?", "Is there a cell with noticeably increased or decreased density, which could be due to changes in cytoplasmic content or degeneration?", "Does any cell exhibit abnormal organelle content, suggesting neoplastic transformation or metabolic dysregulation?", "Can you observe changes in the number of these cells within the tissue, which might relate to disease progression or treatment response in Hodgkin lymphoma?"], "properties": ["Does the image show a cell with a diameter between 20 and 50 micrometers?", "Can you identify a large, round or oval-shaped cell?", "Is there a cell present with two large, mirror-image nuclei, each containing a prominent nucleolus?", "Do you see a cell with abundant, slightly basophilic or granular cytoplasm?", "Is there a cell exhibiting strong eosinophilic cytoplasmic staining and prominent nuclear staining under hematoxylin and eosin?", "Can you find a cell whose nuclei display vesicular chromatin with fine to coarse granularity?", "Is there a cell where each nucleus contains a single, very large, centrally located nucleolus?", "Do you observe a cell with pale to eosinophilic cytoplasm and darkly stained nuclei under light microscopy?", "Is there a cell with a high nuclear-to-cytoplasmic ratio due to large nuclei and abundant cytoplasm?", "Can you identify a cell whose cytoplasmic texture appears smooth to slightly granular?", "Is there a cell that is positive for CD30 and CD15, but negative for most B- and T-cell markers?", "Do you see a cell expressing proteins such as CD30, CD15, or PAX5?", "Is there evidence of a cell with increased DNA content, such as hyperdiploidy or aneuploidy?", "Can you find a cell with a low mitotic index among the observed cells?"], "relational": ["Does the image show a cell within lymphoid tissue that contains two large, mirror-image nuclei?", "Is there a structure present in the lymph nodes that is associated with Hodgkin lymphoma?", "Can you identify a cell that originates from the B lymphocyte lineage?", "Does the image include both binucleate and mononuclear morphological variants of a cell type found in Hodgkin lymphoma?", "Is there a cell surrounded by eosinophils, lymphocytes, or plasma cells?", "Can you see a cell located within cervical, mediastinal, or axillary lymph nodes?", "Does the image show a cell interacting with lymphatic sinuses or germinal centers within a lymph node?", "Is there a structure related to Hodgkin cells present in the image?"], "contexual_behavior": ["Does the image show a cell type that increases cytokine secretion within a tumor microenvironment, especially during the progression of a lymphoid malignancy?", "Is there evidence of a cell that resists inducing apoptosis in surrounding lymphocytes, possibly due to high levels of anti-apoptotic proteins or immunosuppressive cytokine release?", "Can you identify a cell that may be enhancing immune evasion by upregulating PD-L1 or secreting immunosuppressive factors in the context of Hodgkin lymphoma?", "Does the image contain a cell with reduced antigen presentation capacity, potentially due to downregulation of MHC class I and II molecules?", "Is there a cell present that might alter its proliferative activity in response to chemotherapy, such as by activating survival pathways or entering cell cycle arrest?", "Can you see a cell that increases production of growth factors under hypoxic conditions, possibly by upregulating hypoxia-inducible factors?", "Is there evidence of a cell type that impairs normal lymph node architecture through accumulation and proliferation within lymphoid tissue?", "Does the image show a cell that decreases recruitment of inflammatory cells when chemokine secretion or signaling pathways are inhibited?", "Can you identify a cell that may change its signaling pathways during relapse of Hodgkin lymphoma by activating alternative survival or proliferation mechanisms?", "Is there a cell that shows reduced resistance to immune cell-mediated cytotoxicity when immune checkpoint molecules are blocked or immune effector functions are restored?", "Does the image contain a cell that increases secretion of immunosuppressive molecules in response to interactions with regulatory T cells and the tumor microenvironment?", "Is there a cell that alters its metabolic activity under nutrient deprivation by shifting to glycolytic metabolism and upregulating stress response pathways?", "Can you see a cell that fails to maintain a multinucleated state during mitosis, possibly due to mitotic errors or defects in cytokinesis?", "Is there evidence of a cell that enhances its survival mechanisms under oxidative stress by increasing antioxidant enzyme expression or activating stress response pathways?", "Does the image show a cell that reduces its interaction with stromal cells in the lymph node when adhesion molecule expression is downregulated or the microenvironment is altered?"], "functions": ["Does the image show a cell type that drives the pathology of Hodgkin lymphoma through malignant transformation?", "Is there evidence of abnormal cell proliferation or disruption of normal lymphoid tissue in the image?", "Can you identify a cell that may be secreting cytokines to modulate the immune response?", "Does the image contain a cell that appears to be recruiting T cells, eosinophils, or macrophages through cell-cell interactions?", "Is there a structure in the image that could be associated with activation of NF-\u03baB, JAK/STAT, or PI3K/AKT signaling pathways?", "Can you see features suggesting alteration of the tumor microenvironment, such as changes in immune cell composition or signs of immunosuppression?", "Is there a cell present that could be producing cytokines like IL-5, IL-13, or TGF-\u03b2 to regulate immune responses?", "Does the image show a cell that might evade immune detection by downregulating MHC molecules or expressing immune checkpoint ligands?", "Are there signs of disrupted lymph node architecture, such as fibrosis, loss of normal nodal structure, or formation of tumor cell-rich areas?", "Can you identify a cell that promotes proliferation and survival through constitutive activation of growth and anti-apoptotic pathways?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a gene with moderate expression in healthy tissues, especially in the colon, liver, or breast?", "Does the image provide evidence for common mutations such as E545K, H1047R, or E542K?", "Is there a protein present with a molecular weight of about 124 kilodaltons?"], "relational": ["Does the image suggest involvement in the endocrine, immune, or nervous systems?", "Can you identify a catalytic subunit that is part of the phosphatidylinositol 3-kinase complex?", "Can you identify a protein present in epithelial, endothelial, or immune cells?"], "contexual_behavior": [], "functions": ["Can you see indications of enhanced cell survival or reduced apoptosis, possibly due to AKT activation?", "Can you see signs of cellular responses to growth factors, such as activation of receptor tyrosine kinases or downstream effectors?", "Can you identify areas where cell migration or cytoskeletal remodeling might be occurring, possibly due to PI3K-dependent signaling?"]}}, "glandular crowding": {"yes_questions": {"contexual_properties": ["Does the image show tissue with features suggestive of epithelial hyperplasia or neoplastic transformation?", "Can you identify areas where gland density appears increased, as seen in proliferative or pre-neoplastic lesions?", "Is there evidence of architectural distortion that could indicate invasive carcinoma or complex hyperplasia?", "Does the tissue display irregular glandular arrangements typical of dysplasia or malignancy?", "Can you observe loss of normal gland spacing, as might occur in atypical hyperplasia or carcinoma?", "Is there increased nuclear overlap present, which is characteristic of dysplastic or cancerous tissues?", "Do you see signs of high mitotic activity in regions that may represent rapidly proliferating or malignant lesions?", "Are there visible stromal changes associated with endometrial hyperplasia or neoplastic processes?", "Does the image contain features consistent with reactive epithelial changes due to inflammation?", "Can you identify areas where glandular patterns are abnormal, as seen in atypical hyperplasia or carcinoma in situ?", "Is there evidence of glandular crowding that becomes more pronounced in high-grade dysplasia or malignant lesions?", "Do you observe changes in glandular density that could indicate proliferative disorders or neoplastic progression?", "Are there features suggesting the presence of benign or malignant tumors associated with abnormal glandular arrangements?", "Can you see tissue regions where glandular crowding appears reduced, possibly indicating resolution of hyperplastic or inflammatory processes?", "Is there visual evidence of cellular atypia in areas with abnormal glandular architecture, as seen in precancerous or malignant conditions?"], "properties": ["Does the image show an area where glands are closely packed together with little intervening stroma?", "Can you identify a region where the number of glands per unit area appears significantly increased, possibly exceeding 10 per low-power field?", "Is there evidence of glands that are small to medium in size with irregular outlines?", "Do you observe glandular structures with irregular or angulated shapes, or arranged back-to-back?", "Is the distance between adjacent glands reduced, with minimal or no stroma separating them?", "Can you see an area where the cellular density is increased due to closely apposed glands and higher epithelial content?", "Is there a region where the nuclear-to-cytoplasmic ratio appears elevated, with nuclei that seem enlarged relative to the cytoplasm?", "Do any glandular lumens appear compressed, slit-like, or absent due to close packing of glands?", "Is there evidence of increased mitotic activity, such as 2 to 5 mitoses per 10 high-power fields, suggesting increased proliferation?", "Can you identify a complex architectural pattern, such as cribriform or fused glandular arrangements, in the image?"], "relational": ["Does the image show regions where glands are closely packed with little separation by stromal tissue?", "Can you identify areas with increased density of glands within an epithelial layer?", "Is there evidence of altered glandular architecture, such as overlapping glandular profiles?", "Does the image contain structures that could be classified as tubular, acinar, or endometrial glands?", "Are there visible changes to the basement membrane or stromal matrix in association with densely arranged glands?", "Can you see epithelial or mucosal tissue with reduced stromal separation between glandular elements?", "Is there a region in the image that could correspond to the endometrium, prostate, colorectal mucosa, or breast tissue showing abnormal glandular arrangements?", "Are there microscopic features such as nuclear atypia, mitotic figures, or architectural distortion present in areas with crowded glands?", "Does the image display glandular proliferation within an organ parenchyma or epithelial compartment?", "Can you identify ducts or epithelial layers affected by increased gland density?"], "contexual_behavior": ["Does the image show evidence of increased glandular proliferation and reduced cell death, as might be seen during chronic inflammation?", "Can you identify a region where excessive cellular density appears to disrupt the normal architecture of acini or ducts, potentially impairing secretion?", "Is there a visible area where abnormal cell growth and loss of normal tissue constraints suggest a neoplastic process?", "Does the image display an increased number of glandular cells within a confined space, indicating possible hyperplasia and architectural disruption?", "Can you observe features in endocrine tissue where excessive proliferation may be affecting hormone production?", "Is there a region where overcrowding of glandular cells could be limiting nutrient or oxygen delivery, potentially reducing gland function?", "Does the image suggest that trophic hormone stimulation has led to increased glandular cell proliferation?", "Can you see signs of tissue repair or restored glandular spacing that might indicate resolution of prior injury?", "Is there evidence that high cell density is interfering with normal cellular differentiation or developmental signaling pathways?", "Does the image show crowded glands compressing or obstructing ductal lumens, which could impair drainage?", "Is there a region where chronic overcrowding may have led to abnormal cell behavior or features suggestive of malignant transformation?", "Can you identify areas where the vascular supply appears insufficient for the increased glandular cell mass, possibly resulting in decreased nutrient delivery?", "Does the image show signs of tissue remodeling, such as removal of excess glandular cells and restoration of normal architecture?", "Is there evidence that dense cellular arrangements are hindering immune cell access or infiltration within glandular tissue?", "Can you observe a decrease in glandular crowding that might be associated with effective treatment or resolution of inflammation?"], "functions": ["Does the image show regions where the space between glands is reduced, potentially increasing cellular density?", "Can you identify areas where the normal arrangement of glands appears disrupted or crowded?", "Is there evidence of impaired secretion, such as glands with obstructed or narrowed lumens?", "Does the image display features suggesting secretory dysfunction or blockage within glandular structures?", "Are there signs of tissue remodeling, such as changes in the extracellular matrix or increased cellular proliferation?", "Can you observe alterations in tissue architecture, like irregular gland shapes or loss of normal spacing?", "Is there visual evidence of abnormal glandular growth, such as clusters of proliferating cells or architectural distortion?", "Do you see indications of pathological changes, such as features consistent with dysplasia or neoplasia in glandular tissue?", "Are there areas where glandular cells appear to be in closer proximity, possibly affecting cell-cell interactions or paracrine signaling?", "Does the image suggest compromised nutrient or oxygen delivery, such as reduced vascular supply to densely packed glandular regions?", "Can you identify changes in epithelial cell behavior, such as altered polarity or migration patterns due to crowded conditions?", "Is there evidence that the local microenvironment around glands is altered, potentially affecting hormonal responses or receptor accessibility?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a sample in a test tube that might have a low glucose concentration, less than 40 milligrams per deciliter?", "Is there a substance in a test tube that appears turbid or opaque?", "Does the test tube contain material that could have an elevated lactate dehydrogenase (LDH) level above 1000 units per liter?"], "relational": ["Is there material in the test tube that might be associated with the respiratory tract or internal organs as a source?", "Does the image show a substance that could contain dead leukocytes, bacteria, or protein-rich fluid?", "Can you identify material in the test tube that might contain immune cells like neutrophils or macrophages?"], "contexual_behavior": ["Is there a sample that could show decreased proteolytic activity if kept under low temperature conditions, as enzymatic reactions would be slowed?", "Can you identify a specimen that would lose its ability to neutralize pathogens if immune components were degraded or depleted?", "Does the specimen appear to have diminished neutrophil activity, which could occur after extended incubation as neutrophils undergo apoptosis or lose functionality?"], "functions": ["Does the material in the test tube appear to be a site for immune cell recruitment and cytokine activity?", "Can you see evidence of a process where dead cells and debris are being removed by phagocytes?", "Is there a sample that could be supporting wound healing by isolating infectious agents and promoting tissue repair?"]}}}
[ { "answer": "typical excellent pinworm", "extracted_concepts": [ "pinworm" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "pinworm" ], "question": "does this image show typical excellent pinworm?" }, { "answer": "no", "extracted_concepts": [ "pinworm", "acid" ], "question": "does acid show typical excellent pinworm?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "myocardium" ], "question": "is myocardium present?" }, { "answer": "appendix", "extracted_concepts": [ "appendix" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "appendix" ], "question": "is appendix present?" }, { "answer": "no", "extracted_concepts": [ "carcinoma metastatic lung" ], "question": "is carcinoma metastatic lung present?" }, { "answer": "pinworm", "extracted_concepts": [ "pinworm" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "pinworm" ], "question": "is pinworm present?" }, { "answer": "no", "extracted_concepts": [ "normal ovary" ], "question": "is normal ovary present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "appendix", "extracted_concepts": [ "appendix" ], "question": "what is present?" }, { "answer": "pinworm", "extracted_concepts": [ "pinworm" ], "question": "what is present?" } ]	["acid", "carcinoma metastatic lung", "myocardium", "normal ovary", "gastrointestinal", "pinworm", "gastrointestinal system", "appendix"]	{"acid": {"yes_questions": {"contexual_properties": ["Does the image show a solution whose concentration could increase if more solute is added or if some solvent is removed?", "Is there evidence of a substance that would become more diluted if additional solvent, such as water, were mixed in?", "Can you identify a scenario where the pH might change due to variation in hydrogen ion concentration?", "Does the image depict a situation where the composition of a chemical could be altered by the introduction of new species or by a chemical reaction?", "Is there a visible color change that could result from a chemical reaction, the addition of an indicator, or exposure to light?", "Can you see a substance that would become more corrosive if its concentration increased or if it were mixed with other reactive chemicals?", "Is there a context where a substance could become less corrosive through dilution or neutralization?", "Does the image show a container where the volume of a liquid could increase by adding more solute or solvent?", "Is there evidence that the volume of a solution might decrease due to evaporation or removal of material?", "Can you identify a scenario where the density of a liquid might change due to alterations in concentration or temperature?", "Is there a depiction of tissue where accumulation of a certain substance could occur during metabolic disorders such as lactic acidosis or ischemia?", "Does the image suggest elevated levels of a compound in blood during conditions like diabetic ketoacidosis or renal dysfunction?", "Is there a situation where the level of a substance in urine might decrease during metabolic alkalosis or impaired renal excretion?", "Can you see any indication of abnormal levels of a chemical during diseases such as acidosis, poisoning, or renal disease?", "Is there a depiction of the stomach where the content of a particular substance increases after food intake or stimulation by a hormone?", "Does the image show a scenario where the content of a compound in the stomach decreases during fasting or after administration of a neutralizing agent?", "Is there evidence of a substance appearing in an abnormal location, such as during reflux or tissue injury?", "Can you identify a situation where a chemical might become more volatile when heated or if it is a low-boiling-point compound?"], "properties": ["Does the image show a substance that could have a chemical formula like HCl, H2SO4, or CH3COOH?", "Is there an object present whose molecular weight might be around 36.46 g/mol or 98.08 g/mol?", "Can you identify a solution that would likely have a pH less than 7?", "Is there a colorless liquid or substance visible that could be pure or nearly pure?", "Does the image contain a material with a density similar to 1.19 g/cm\u00b3 or 1.84 g/cm\u00b3?", "Can you see a substance that might boil at around 110\u00b0C or 337\u00b0C?", "Is there an object that could melt at temperatures like \u2212114\u00b0C or 10\u00b0C?", "Does the image show a substance that appears highly soluble in water?", "Is there a container or solution that could plausibly have a concentration near 1 mol/L?", "Can you identify a material that might emit a pungent or vinegar-like odor?", "Is there a liquid present that could have a viscosity similar to 1.84 mPa\u00b7s?", "Does the image contain a solution that could have a very low pKa, such as \u22126.3, or a moderate pKa like 4.76?", "Is there a transparent liquid that could have a refractive index around 1.430?", "Can you see a substance that might have a specific heat capacity near 1.38 J/g\u00b7K?", "Is there a solution or liquid that would likely conduct electricity well due to ionization?", "Does the image show something that could have a sour taste if tasted?", "Is there a solution that might have a measurable osmolarity in osmoles per liter?", "Can you identify a material that appears highly corrosive, especially if it is a strong chemical?", "Is there a substance present that could be a liquid, solid, or gas at room temperature depending on its identity?", "Does the image show a material that could have a standard enthalpy of formation similar to \u2212167.2 kJ/mol?"], "relational": ["Does the image show an organ system involved in the production or presence of substances that facilitate digestion?", "Can you identify tissues that interact with corrosive substances, such as the gastric mucosa or esophageal epithelium?", "Is there a visible organ known for secreting substances that lower pH, such as the stomach or kidneys?", "Does the image include anatomical structures exposed to acidic environments during digestion, like the stomach lining or duodenum?", "Can you see cells specialized in producing substances that contribute to a low pH environment, such as parietal cells?", "Is there evidence of body fluids that typically contain substances with acidic properties, such as gastric juice or urine?", "Does the image contain structures that play a role in pathogen defense or nutrient absorption through the action of low pH?", "Can you identify organs or tissues involved in regulating the concentration of hydrogen ions, such as the kidneys or lungs?", "Is there a structure present that contributes to the neutralization or buffering of low pH substances, like the pancreas or liver?", "Does the image show anatomical compartments where acid-base balance is maintained, such as blood plasma or interstitial fluid?"], "contexual_behavior": [], "functions": ["Is there evidence of a substance in the image that contributes to the breakdown of food during digestion?", "Can you identify a feature that might be responsible for activating digestive enzymes?", "Does the image show a process or structure that could be involved in denaturing proteins?", "Is there an indication of a component that helps maintain pH balance within the depicted system?", "Can you see something that might facilitate biochemical reactions or act as an intermediate in metabolism?", "Is there a visible structure that could be responsible for killing pathogens or creating a hostile environment for microbes?", "Does the image suggest the presence of a factor that enhances the absorption of minerals or vitamins?", "Can you identify a process that might participate in the citric acid cycle or facilitate ATP production?", "Is there evidence of a mechanism that supports neurotransmitter synthesis or modulates synaptic activity?", "Does the image include a feature that could help regulate electrolyte balance or influence renal function?", "Can you see something that might participate in buffering systems to maintain pH stability?", "Is there a structure or process that could hydrolyze macromolecules to aid nutrient breakdown?", "Does the image suggest the presence of a factor that provides optimal conditions for enzyme activity?", "Can you identify a component that might disrupt hydrogen bonds to alter protein structure?", "Is there evidence of a process that could support electron transport or drive metabolic pathways?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a growth arising from or closely related to the ovary?", "Can you identify a structure that invades or compresses the ovarian capsule, fallopian tube, uterus, or other pelvic organs?", "Is there an abnormal structure involving the ovary or, in more advanced cases, the uterus or peritoneum?"], "contexual_behavior": [], "functions": ["Does the image contain a structure that could lead to excess estrogen secretion?", "Does the image show evidence of tissue invasion or compression affecting surrounding ovarian tissue?", "Is there a mass present that could be responsible for altering endocrine function within the ovary?"]}}, "carcinoma metastatic lung": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of abnormal tissue that could indicate the spread of malignant cells to the lung?", "Is there a region in the lung that appears different from normal lung tissue, suggesting possible infiltration by cancerous cells?", "Can you identify any masses or lesions within the lung that might represent secondary tumor growth?"], "relational": ["Does the image show evidence of a process affecting the respiratory system?", "Can you identify lesions that might originate from sites such as the breast, colon, prostate, kidney, thyroid, or melanoma?", "Is there an abnormality involving the lung parenchyma, pleura, or bronchi?", "Does the image reveal invasion of alveolar tissue, bronchial epithelium, or the pulmonary interstitium?", "Are there signs of involvement of hilar, mediastinal, or supraclavicular lymph nodes?", "Can you see abnormalities associated with the pulmonary arteries, pulmonary veins, or bronchial arteries?", "Is there a lesion adjacent to the pleura, chest wall, diaphragm, or mediastinum?", "Does the image suggest secondary involvement of organs such as the brain, liver, adrenal glands, or bone?", "Are there features indicating obstruction or narrowing of the bronchial tree, such as airway narrowing or atelectasis?", "Can you identify changes within the pleural, pericardial, or thoracic cavities that may be related to a metastatic process?"], "contexual_behavior": [], "functions": ["Is there evidence of a process characterized by uncontrolled cell proliferation and tissue invasion?", "Can you identify a region where normal lung tissue appears to be replaced or disrupted?", "Does the image show signs of airway obstruction that could impair respiratory function?", "Is there a structure suggesting the spread of abnormal cells to distant organs via blood vessels or lymphatics?", "Can you observe features consistent with degradation of the extracellular matrix or disruption of basement membranes?", "Is there visual evidence of increased blood vessel formation, possibly due to the release of pro-angiogenic factors?", "Does the image suggest a reduction in alveolar surface area or destruction of alveolar-capillary units?", "Can you identify areas where interstitial thickening or tissue remodeling is apparent?", "Is there any indication of fibroblast activation or increased extracellular matrix deposition within the lung tissue?", "Does the image show infiltration of immune or inflammatory cells, suggesting an ongoing inflammatory response?", "Can you observe modifications in the lung microenvironment, such as changes in stromal cell appearance or recruitment of additional cell types?", "Is there evidence of cachexia or systemic effects, such as tissue wasting, that might result from the release of catabolic cytokines?", "Does the image display features that could be associated with ventilation-perfusion mismatch?", "Can you identify areas where oncogenic signaling might be activated or tumor suppressor pathways inhibited, as suggested by abnormal cellular architecture?", "Is there visual evidence of immune evasion, such as reduced immune cell presence in regions of abnormal tissue?"]}, "no_questions": {"contexual_properties": ["Is there a rim of iron-containing pigment surrounding a lesion, suggesting hemosiderin accumulation at the margin in the chronic phase?", "Is there an area that appears more pronounced or hyperdense on imaging, possibly due to recent blood accumulation?", "Is there an area with increased mass effect, such as compression of adjacent structures, due to edema or hematoma expansion in the acute to subacute phase?"], "properties": ["Is there a lesion measuring between 1 and 5 centimeters in diameter visible in the image?", "Does the image reveal a lesion with heterogeneous signal intensity, including both hypointense and hyperintense regions, as might be seen on MRI?", "Can you identify an area with an irregular or wedge-shaped appearance?"], "relational": ["Does the image show a localized abnormality affecting the central nervous system, cardiovascular system, or pulmonary system?", "Does the lesion have boundaries defined by vascular territories, tissue planes, or infarct margins?", "Is there an area where arteries, veins, or capillaries appear disrupted or abnormal?"], "contexual_behavior": ["Can you identify a well-demarcated zone where tissue appears infarcted and contains blood extravasation?", "Does the image show a focal lesion characterized by both necrosis and hemorrhagic features?", "Does the image display a region with evidence of localized tissue damage accompanied by bleeding?"], "functions": ["Does the image show a region where tissue appears damaged due to both lack of blood flow and bleeding?", "Does the image reveal loss of neurons or glial cells in a specific brain region that could lead to neurological deficits?", "Is there a region that suggests breakdown of the blood-brain barrier, possibly indicated by increased permeability or endothelial injury?"]}}, "myocardium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the cardiovascular system?", "Can you identify the muscular layer within the heart wall?", "Is there a region in the heart that lies between the endocardium and the epicardium?", "Does the image display tissue composed mainly of cardiac muscle cells?", "Can you see an area supplied by the coronary arteries or drained by the coronary veins?", "Is there a structure adjacent to both the endocardium and the cardiac valves?", "Do all four heart chambers in the image contain a common muscular component?", "Can you identify the middle layer of the heart wall, situated beneath the endocardium?", "Is there a layer covered externally by the epicardium in the heart?", "Does the image show tissue associated with the cardiac extracellular matrix, including collagen or elastic fibers?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for generating the force needed for heartbeats and blood circulation?", "Is there evidence of tissue that contracts rhythmically to propel blood through chambers and vessels?", "Can you identify an area where coordinated shortening of muscle fibers in response to electrical signals might occur?", "Does the image contain a region that increases pressure within the heart chambers during contraction?", "Is there a structure that responds to electrical impulses by initiating contraction and ensuring synchronized heartbeats?", "Can you see tissue that maintains cardiac rhythm by propagating electrical signals throughout the heart?", "Is there evidence of adaptation to increased physical activity, such as enhanced contractility or increased output?", "Does the image show a region that could regulate blood pressure by adjusting the force and rate of contraction?", "Can you identify tissue that supports oxygen delivery by maintaining effective blood flow to other organs?", "Is there a structure that might alter its contractility or stroke volume in response to changes in blood volume?", "Does the image contain tissue involved in modulating heart rate and contractile strength based on physiological needs?", "Can you see evidence of compensatory mechanisms, such as thickened muscle or structural changes, that protect the heart from overload?", "Is there any indication of tissue repair or remodeling processes following injury or stress in the heart?"]}, "no_questions": {"contexual_properties": ["Does the image show a paired structure located opposite to another similar organ?", "Is there a visible organ that is anatomically situated contralateral to another ovary in the image?", "Can you identify a structure that mirrors the position of an ovary on the other side of the body?"], "properties": ["Is there a region that appears homogeneous on ultrasound with multiple small anechoic areas?", "Can you identify an object that may have a water content of about 70\u201380% by weight?", "Does the image show a region where estradiol and progesterone concentrations might fluctuate during the menstrual cycle?"], "relational": ["Does the image show a structure that is part of the female reproductive system and located on the opposite side of the body relative to another similar structure?", "Can you identify an object that is laterally positioned to the uterus and connected by ligaments?", "Does the image contain a structure that is contralateral to another similar organ, indicating it is on the opposite side?"], "contexual_behavior": ["Does the image show a counterpart structure on the other side of the body relative to the main organ of interest?", "Can you identify an organ that is typically paired and may be located contralaterally to the main focus of the image?", "Is there a structure present on the side opposite to the one being primarily depicted?"], "functions": ["Is there an object that responds to gonadotropin stimulation by promoting follicular development and steroid hormone synthesis?", "Can you identify an organ that provides viable gametes for fertilization?", "Is there a structure that synthesizes and releases estrogen and progesterone?"]}}, "normal ovary": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image contain a structure that is part of the female reproductive system?", "Can you identify an object located within the pelvic cavity?", "Is there a structure anatomically adjacent to the fallopian tube or uterus?", "Does the image show something supported by ligaments such as the ovarian ligament or suspensory ligament?", "Can you see a structure that receives blood from the ovarian artery or is drained by the ovarian vein?", "Is there an object connected to the fallopian tube via fimbriae?", "Does the image contain a structure with distinct regions such as a cortex, medulla, or surface epithelium?", "Can you identify an object connected to the uterus by a ligament?", "Is there a structure that participates in the menstrual cycle?", "Does the image show a tissue containing oocytes or specialized cells like granulosa or theca cells?", "Can you see an object that interacts anatomically with the urinary bladder?", "Is there a structure whose position or relationship to the pelvic wall can be observed?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for producing hormones that regulate the menstrual cycle?", "Can you identify an organ that supports the maturation of oocytes within follicles?", "Is there a structure that initiates the release of a mature egg in response to hormonal signals?", "Does the image contain an organ that synthesizes estrogen, progesterone, or inhibin?", "Can you see a structure that contributes to fertility by producing viable eggs?", "Is there an object that maintains hormonal balance necessary for conception?", "Does the image show a structure involved in the cyclical secretion of reproductive hormones?", "Can you identify an organ that influences secondary sexual characteristics through hormone production?", "Is there a structure that ensures regular ovulatory cycles and balanced hormone levels for reproductive health?", "Does the image contain an organ interacting with the hypothalamic-pituitary-gonadal axis via feedback mechanisms?", "Can you see a structure where follicle development progresses from primordial to preovulatory stages under hormonal control?", "Is there an object that responds to follicle-stimulating hormone and luteinizing hormone to coordinate reproductive events?", "Does the image show a structure that adjusts hormone production during puberty, reproductive years, and menopause?"]}, "no_questions": {"contexual_properties": ["Can you observe altered distribution of staining in areas that might correspond to dysplastic or neoplastic tissue?", "Is there reduced staining intensity in areas that may correspond to poorly differentiated tumors or regions with low protein expression?", "Does the image reveal heterogeneous staining in tumors with mixed cell populations or variable protein expression?"], "properties": ["Does the staining pattern suggest that the optimal antibody dilution was within the range of 1:50 to 1:200?", "Is there evidence of a highly sensitive method for detecting epithelial cells expressing a particular intermediate filament protein?", "Can you identify a staining pattern that is cytoplasmic, possibly with membranous accentuation, in epithelial cells?"], "relational": ["Can you assess cellular localization, staining intensity, or distribution pattern in the stained tissue?", "Does the image show a staining pattern that could be used to analyze tissues such as the lung, breast, or ovary?", "Does the image contain structures from organs commonly associated with cytoskeletal protein expression, such as the pancreas or biliary tract?"], "contexual_behavior": ["Can you identify regions of a carcinoma with diminished staining, suggesting a loss of epithelial differentiation?", "Is there reduced detection of epithelial cells in areas with extensive fibrosis, suggesting limited antibody penetration?", "Do you see enhanced staining in tissues that might have been exposed to chemotherapeutic agents, indicating upregulation of the target antigen?"], "functions": ["Is there a staining pattern that could help differentiate between various epithelial tissues?", "Does the image contain information that could be used to monitor changes in protein expression during tumor development?", "Does the image provide visual information that could be used for functional characterization of tumors through assessment of a specific protein marker?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of a skull without visible sutures separating individual bones?", "Can you identify a cranial vault that lacks the typical segmentation seen in normal skull anatomy?", "Does the image show a cranial structure where the bones appear to be fused into a single unit?"], "relational": ["Does the image contain a structure that includes the cranial vault and calvarial roof?", "Can you see evidence of tissues such as periosteum, dura mater, or scalp attached to a bony surface?", "Is there a structure that connects to the facial skeleton through features like the cranial base or zygomatic arches?"], "contexual_behavior": ["Can you identify a region of the skull that lacks visible sutures between its major components?", "Does the image show a structure where multiple cranial bones appear to be joined together as a single unit?", "Is there evidence of fusion among the bones that typically form the cranial vault?"], "functions": ["Does the image show a rigid, continuous bony shell that could serve as a barrier against trauma to the brain?", "Can you identify a feature that plays a role in shaping and enclosing the cranial cavity during development?", "Is there a structure that encloses cranial blood vessels within bony grooves or foramina, offering vascular protection?"]}}, "pinworm": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an organism in the image that appears white or translucent?", "Can you identify a slender, cylindrical, and tapering structure that is unsegmented?", "Does the image show an object with a smooth surface and fine transverse striations?", "Is there a structure present that measures between 8 and 13 millimeters in length or between 2 and 5 millimeters in length?", "Can you see an object with a width of approximately 0.3 to 0.5 millimeters?", "Is there evidence of an organism that could weigh less than 1 milligram?", "Does the image contain an object that might tolerate temperatures between 20 and 40 degrees Celsius?", "Can you identify a structure whose body is composed primarily of collagen and other structural proteins?", "Is there a visible organism that could have a water content of 70 to 80 percent of its body weight?", "Does the image show an object that might have a protein content of 10 to 20 percent of its dry weight?", "Is there a structure present with a carbohydrate content of roughly 2 to 5 percent of its dry weight?", "Can you see an organism with a lipid content of approximately 5 to 10 percent of its dry weight?", "Is there an object that could survive in a pH range between 6 and 8?", "Does the image contain a structure with a density close to 1.05 grams per cubic centimeter?", "Can you identify an organism that is unsegmented and belongs to the nematode group?", "Is there evidence of a reproductive structure capable of producing thousands of eggs per cycle?", "Can you see any eggs measuring about 50 to 60 micrometers by 20 to 30 micrometers?", "Is there a structure that might have a nucleic acid content of 2 to 4 percent of its dry weight?", "Does the image show an organism with a typical lifespan of about 2 months?"], "relational": ["Does the image show an organism inhabiting the gastrointestinal system?", "Is there evidence of a structure affecting the perianal region or lower intestine?", "Can you identify something interacting with the intestinal mucosa or perianal skin?", "Is there a visible entity that could have entered through the oral cavity or digestive tract?", "Does the image include an organism present in the cecum, colon, or rectum?", "Can you see signs of egg deposition or irritation in the perianal area?", "Is there a structure associated with the large intestine or anus in the image?", "Does the image show an organism encountering barriers such as gastric acid, intestinal mucus, or the anal sphincter?", "Is there evidence of structural impact on the digestive or integumentary systems?", "Can you identify an organism attached to the intestinal mucosa, potentially causing localized irritation?"], "contexual_behavior": ["Does the image show an organism that increases its reproductive activity when its human host is asleep at night?", "Is there evidence of a parasite that migrates toward the perianal region during host sleep for optimal egg deposition?", "Can you identify a structure whose egg-laying behavior might be suppressed by an effective host immune response?", "Is there an organism present that cannot complete its life cycle in non-human hosts due to host specificity?", "Does the image contain a parasite that increases its feeding activity in malnourished hosts to acquire more nutrients?", "Is there a structure whose survival rate would decrease in response to antiparasitic treatments such as mebendazole or albendazole?", "Can you see an organism that would show impaired motility in an unfavorable gut environment, such as one with altered pH or disrupted microbiota?", "Is there evidence of a parasite that increases its transmission in crowded living conditions due to higher rates of person-to-person contact?", "Does the image show an organism whose infectivity is reduced after repeated host immune challenges?", "Can you identify a parasite that alters its behavior in response to changes in the host's gut microbiota, potentially affecting its migration and reproduction?", "Is there evidence of an organism that forms robust eggs with protective shells to increase resistance to environmental stress outside the host?", "Does the image contain a parasite whose eggs may fail to hatch in low humidity due to environmental requirements for embryonation?", "Is there an organism that increases its nocturnal activity to deposit eggs on the perianal skin, emerging at night in sync with the host's circadian rhythm?", "Can you see a parasite that decreases its metabolic activity during host fasting to conserve energy?", "Is there evidence of an organism that alters its function in immunocompromised hosts, potentially increasing its reproductive output and persistence?"], "functions": ["Is there evidence of an organism colonizing the colon or rectum in the image?", "Can you identify signs of egg deposition in the perianal region?", "Does the image suggest the presence of a cause for pruritus ani?", "Is there a structure that could be responsible for gastrointestinal symptoms such as abdominal discomfort?", "Can you see any indication of irritation or inflammation of the intestinal mucosa?", "Does the image show features consistent with a local inflammatory response or mild eosinophilia in the tissue?", "Is there evidence of nocturnal egg laying or surface contamination that could facilitate host-to-host spread?", "Can you identify an organism that resides in the intestinal lumen without invading tissues?", "Does the image suggest the presence of a non-invasive organism with minimal impact on nutrient absorption?", "Is there visual evidence of rapid reproduction or multiple life stages of a parasite within the intestinal lumen?", "Can you see any signs of environmental contamination, such as eggs on surfaces or bedding, that could enable fecal-oral transmission?", "Does the image show features that could be associated with direct contact transmission between hosts?", "Is there evidence of an organism whose lifecycle includes egg ingestion, larval hatching in the small intestine, and maturation in the colon?"]}, "no_questions": {"contexual_properties": ["Does the image show an area that appears swollen, possibly due to trauma or infection?", "Is there a region that appears warmer than surrounding areas, which could indicate infection or cellulitis?", "Is there a region where the normal contour is lost, possibly due to swelling, mass formation, or deformity?"], "properties": ["Can you see an area where the thickness is not uniform and appears to be determined by the underlying anatomical structure?", "Is there a structure whose width and length seem to depend on the specific organ or region depicted?", "Is there a region that might have a water content similar to the surrounding tissue, typically between 60% and 80%?"], "relational": ["Does the image include muscles such as the gracilis, adductor longus, adductor brevis, or adductor magnus located on the inner thigh?", "Is there a joint visible, such as the knee, elbow, or ankle, where you can distinguish the side nearest to the midline?", "Does the image show a structure that is closer to the body's midline compared to others?"], "contexual_behavior": ["Can you observe increased mechanical stress or load on the inner side of a limb or joint, as might occur with abnormal gait patterns such as overpronation or knock-knee alignment?", "Is there evidence of impaired growth or deformity on the inner side of a bone, which could be consistent with developmental disorders such as Blount disease or rickets?", "Is there a sign of instability on the inner side of the knee that could suggest damage to a ligament responsible for resisting valgus forces?"], "functions": ["Can you identify a structure that aligns with the midline axis and appears to transmit weight-bearing forces efficiently across the body?", "Is there an area visible that provides attachment sites for ligaments or muscles resisting lateral forces to enhance joint stability?", "Does the image display anatomical landmarks that could guide muscle attachment and influence muscle function?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": ["Is there a yellowish fluid visible, which could indicate the presence of pus rich in neutrophils and cellular debris?", "Does the fluid appear protein-rich, which could result from increased endothelial permeability due to inflammation?", "Can you see fluid with a high cellular content, possibly related to intense inflammation, infection, or tissue necrosis?"], "properties": ["Is there a visible fluid that could be associated with a faint, musty, or foul odor?", "Does the image show a fluid that might have a high viscosity compared to other body fluids?", "Is there evidence of a substance that could contain a high number of inflammatory cells such as neutrophils or macrophages?"], "relational": ["Can you see any signs of increased permeability in blood vessels or capillaries, such as fluid or cells escaping into surrounding tissues?", "Is there a visible collection of material that might contain neutrophils, macrophages, lymphocytes, or erythrocytes?", "Can you identify a region where connective, epithelial, or endothelial tissue appears to be undergoing inflammation or injury?"], "contexual_behavior": ["Is there evidence of excessive fluid in the pleural space, suggesting pleural effusion due to inflammation or infection?", "Does the image reveal accelerated fluid accumulation and leukocyte migration that could be associated with tissue injury?", "Can you identify an area where fluid appears more protein-rich, possibly due to widened endothelial gaps in response to infection?"], "functions": ["Is there a feature that might be delivering nutrients such as proteins, glucose, or electrolytes to damaged tissues?", "Can you identify an area where increased fluid volume could be diluting toxins at a site of inflammation?", "Is there a visible accumulation that might be delivering plasma proteins or leukocytes to affected tissues?"]}}, "appendix": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a narrow, blind-ended tubular structure visible in the image?", "Can you identify an object that measures between 6 and 10 centimeters in length?", "Does the image show a structure with a diameter of about 6 millimeters?", "Is there a soft, pliable structure present among the tissues?", "Can you see something with a pinkish-gray color similar to other intestinal tissues?", "Is there a feature whose wall thickness appears to be around 2 to 3 millimeters?", "Does the image include a structure that could weigh between 7 and 10 grams?", "Can you identify a region that contains abundant lymphoid tissue, especially in the submucosa?", "Is there a tubular structure that receives blood supply from a branch of the ileocolic artery?", "Can you see a tissue with a water content estimated at 70 to 80 percent by weight?", "Is there a structure lined by simple columnar epithelium with goblet cells?", "Does the image show a region with moderate mucin content produced by goblet cells?", "Can you identify an object with a volume of about 1 to 2 milliliters?", "Is there a tissue whose density is close to 1.05 grams per cubic centimeter?", "Can you see a structure whose temperature would match core body temperature, around 37 degrees Celsius?", "Is there a feature with a lumen pH estimated to be neutral to slightly alkaline, around 7.0 to 8.0?", "Does the image include a structure composed of mucosal epithelial cells, lymphocytes, goblet cells, and enteroendocrine cells?"], "relational": ["Does the image show a structure that is part of the digestive system and located in the right lower quadrant of the abdomen?", "Can you identify a blind-ended tube extending from the cecum?", "Is there a structure attached to the posteromedial wall of the cecum?", "Does the image contain an object adjacent to the ileum or parietal peritoneum?", "Can you see a structure that might be supplied by a branch of the ileocolic artery?", "Is there evidence of a wall composed of mucosa, submucosa, muscularis propria, and serosa layers?", "Does the image show prominent lymphoid follicles within submucosal tissue?", "Can you identify a structure that receives innervation from the superior mesenteric plexus or the vagus nerve?", "Is there a tube-like structure surrounded by peritoneal and connective tissue in the image?"], "contexual_behavior": ["Is there a structure in the image that shows increased lymphoid activity in response to gastrointestinal infection?", "Can you identify an object whose immune function might be reduced following antibiotic use due to disrupted gut microbiota?", "Does the image show a structure that could fail to contribute to mucosal immunity in the presence of inflammation and obstruction?", "Is there evidence of tissue remodeling or depletion in lymphoid tissue that could result from chronic inflammation?", "Can you see a structure that might display decreased immune factor secretion in elderly individuals due to atrophy?", "Is there an absence of a structure that would impair the recolonization of beneficial gut bacteria after surgical removal?", "Does the image contain a structure that would be expected to have enhanced defense against pathogens during early childhood?", "Can you identify an object whose immune surveillance might be reduced in an immunocompromised state due to lymphocyte suppression?", "Is there a structure that could increase its activity in response to changes in gut microbial populations?", "Does the image show a structure that might fail to support gut immunity during severe infection due to tissue damage or overwhelming inflammation?"], "functions": ["Does the image show a structure that could serve as a reservoir for lymphoid tissue?", "Is there an object present that might contribute to immune surveillance within the gastrointestinal tract?", "Can you identify a feature that could act as a safe haven for beneficial gut bacteria?", "Does the image contain a component of gut-associated lymphoid tissue, such as one housing lymphocytes or follicles?", "Is there a structure that may facilitate the maturation of B cells or support immune education?", "Can you see an anatomical feature that might participate in the regulation of intestinal bacteria through biofilm formation?", "Is there an object that could be involved in antibody production or immune cell activation?", "Does the image include a structure that may support the proliferation of lymphocytes or the formation of germinal centers?", "Can you identify a region that might help protect against gastrointestinal infections by promoting beneficial microbiota?", "Is there a visible feature that could function as a microbial niche or reservoir for maintaining gut flora?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a gland with an iron content of about 0.1\u20130.2 mg per 100 g of tissue?", "Does the image show a gland with a calcium concentration of about 100\u2013150 mg per 100 g of tissue?", "Is there a structure with a parathyroid hormone content of about 50\u2013100 micrograms per gram of tissue?"], "relational": ["Can you identify structures with lymphatic drainage to the deep cervical or paratracheal lymph nodes?", "Does the image include tissues supplied by the inferior or superior thyroid arteries?", "Can you identify small glands located near or on the posterior surface of the thyroid gland?"], "contexual_behavior": ["Does the image show a gland that could fail to regulate calcium homeostasis in the context of chronic kidney disease?", "Can you see a gland that might reduce its activity following thyroid surgery due to accidental removal or damage?", "Does the image contain a structure whose ability to sense and respond to serum calcium changes could be impaired by glandular damage or genetic defects?"], "functions": ["Is there a structure in the image that plays a key role in regulating calcium and phosphate levels in the body?", "Does the image show a structure involved in maintaining electrolyte balance by controlling extracellular calcium and phosphate concentrations?", "Can you identify an object responsible for secreting a hormone that increases blood calcium by acting on bone, kidneys, and intestines?"]}}}
[ { "answer": "trophozoite source", "extracted_concepts": [ "trophozoite source" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "trophozoite source", "image" ], "question": "does this image show trophozoite source?" }, { "answer": "no", "extracted_concepts": [ "glomerulosa", "trophozoite" ], "question": "does glomerulosa show trophozoite source?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "metastatic carcinoma prostate" ], "question": "is metastatic carcinoma prostate present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "colon" ], "question": "is colon present?" }, { "answer": "no", "extracted_concepts": [ "appendix" ], "question": "is appendix present?" }, { "answer": "amebiasis", "extracted_concepts": [ "amebiasis" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "amebiasis" ], "question": "is amebiasis present?" }, { "answer": "no", "extracted_concepts": [ "lymphangiomatosis" ], "question": "is lymphangiomatosis present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" }, { "answer": "amebiasis", "extracted_concepts": [ "amebiasis" ], "question": "what is present?" } ]	["trophozoite source", "glomerulosa", "amebiasis", "gastrointestinal system", "image", "lymphangiomatosis", "colon", "trophozoite", "gastrointestinal", "metastatic carcinoma prostate", "appendix"]	{"trophozoite source": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears to be increasing in number, suggesting active cell division or asexual reproduction?", "Can you identify an object that has decreased in size, possibly due to nutrient deprivation or environmental stress?", "Is there a structure displaying changes in shape that might indicate movement or adaptation to its environment?", "Do you see an object with increased granularity, which could be a sign of metabolic activity or ingestion of material?", "Is there a structure with altered staining properties, possibly reflecting a shift in metabolic state or cell death?", "Can you observe an object with accumulated vacuoles, suggesting active feeding or osmoregulation?", "Does the image contain a structure with abnormal inclusions that might indicate infection or exposure to toxins?", "Is there evidence of fragmentation in a structure, which could be due to cell death or preparation for encystation?", "Do you see a change in color under microscopy that might result from stain uptake or oxidative stress?", "Is there a structure with increased motility-associated features such as flagella or pseudopodia, indicating active movement or tissue invasion?", "Can you identify an object with surface projections that may be involved in host interaction or immune evasion?", "Does any structure appear to have lost cytoplasmic clarity, possibly due to degeneration or vacuole accumulation?", "Is there a visible change in nuclear appearance that could be associated with mitosis or cellular stress?", "Do you see an object with increased cytoplasmic volume, suggesting growth or preparation for division?", "Is there a structure that appears less refractile, possibly indicating cell death or loss of structural integrity?"], "properties": [], "relational": ["Does the image show a structure that is part of the gastrointestinal system?", "Can you identify tissue resembling intestinal mucosa or liver parenchyma?", "Is there a region corresponding to the colon, small intestine, or liver?", "Does the image contain cells such as epithelial cells, hepatocytes, or immune cells at a potential site of infection?", "Are there visible blood vessels, lymphatic vessels, or bile ducts connected to a region of interest?", "Can you see any body fluids such as intestinal contents, blood, or bile in the image?", "Is there an area that could represent the origin of parasite proliferation?", "Does the image include organs like the liver, intestines, or spleen interacting with a suspicious site?", "Can you identify a region within the abdominal cavity or hepatic region that may be relevant?", "Is there evidence of anatomical barriers such as the intestinal epithelium or mucosal barrier present in the image?"], "contexual_behavior": [], "functions": ["Does the image show an environment or substrate that could support the survival and proliferation of trophozoites?", "Is there a structure present that supplies essential nutrients and optimal conditions for the growth of protozoan cells?", "Can you identify a region that might deliver carbohydrates, amino acids, or other metabolic factors required for protozoan metabolism?", "Does the image include an area that could modulate access to growth factors or environmental cues for protozoan development?", "Is there a visible substrate that appears to maintain the viability of protozoan cells by preventing nutrient depletion and providing stability?", "Can you see a component that determines the availability of substrates for energy production and biosynthesis in protozoan cells?", "Is there a region that could enable cell division and propagation of protozoan cells by ensuring sufficient resources?", "Does the image contain an environment that might offer protection or buffer protozoan cells against environmental stress?", "Can you identify a substrate that could present signals or molecules triggering developmental changes in protozoan cells?", "Is there a structure that might influence the expression of virulence factors or the infectivity of protozoan cells?"]}, "no_questions": {"contexual_properties": [], "properties": ["Are the nuclei of the cells low grade or grade 1 in appearance?", "Is the epithelial cell morphology flattened or cuboidal with minimal atypia?", "Does the fat content appear similar to normal breast tissue or only slightly reduced?"], "relational": ["Does the image reveal changes involving the terminal ducts or lobules?", "Can you see features that are part of the female reproductive system?", "Can you identify any interaction between the lactiferous sinuses and the surrounding adipose tissue in the affected area?"], "contexual_behavior": [], "functions": ["Does the glandular tissue in the breast appear to have preserved secretory function and normal milk production?", "Is there visual evidence of mild ductal changes without active tissue turnover or significant remodeling?", "Does the image show breast tissue with minimal or absent inflammatory response, indicating little immune activation?"]}}, "glomerulosa": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a layer with a thickness between 50 and 150 micrometers?", "Is there a region that measures approximately 0.1 to 0.2 millimeters in width?", "Can you identify an area where cells are about 10 to 15 micrometers in diameter?", "Does the image contain clusters of specialized adrenocortical cells arranged in rounded groups or arcs?", "Is there a structure where the cytoplasm of the cells appears pale and slightly eosinophilic under light microscopy?", "Can you see a light-staining or pale pink layer when viewed microscopically?", "Is there a region with relatively low to moderate lipid content compared to adjacent zones?", "Does the image show cells with moderate mitochondrial density, suggesting steroidogenic activity?", "Can you identify a layer that is responsible for producing approximately 100 to 200 micrograms of aldosterone per day in adults?", "Is there an area with moderate cholesterol content, indicating a role in steroid hormone synthesis?", "Does the image contain tissue with a water content similar to other soft tissues, around 70% by weight?", "Can you see a region where the pH is likely within the physiological range of 7.35 to 7.45?", "Is there a layer composed of only one or two cell layers in thickness?", "Can you identify a region with high expression of CYP11B2 and low expression of CYP17A1 proteins?"], "relational": ["Does the image show a structure that is part of the adrenal gland?", "Is there a layer visible within the adrenal cortex?", "Can you identify the outermost layer of the adrenal cortex in the image?", "Is there a region situated just beneath the adrenal capsule?", "Does the image contain a layer that lies above the zona fasciculata?", "Can you see a structure adjacent to both the adrenal capsule and the zona fasciculata?", "Is there a region composed primarily of specialized adrenocortical cells?", "Can you identify an area that receives blood from adrenal cortical arteries?", "Does the image show a superficial layer of the adrenal cortex organized beneath the capsule?", "Is there evidence of connective tissue interaction with a cortical zone near the surface of the adrenal gland?", "Can you see structures corresponding to the zona fasciculata or zona reticularis alongside another cortical zone?"], "contexual_behavior": [], "functions": ["Does the image show a region responsible for secreting hormones that regulate electrolyte and fluid balance?", "Is there a structure present that synthesizes aldosterone, a key mineralocorticoid hormone?", "Can you identify the exclusive site of aldosterone production within the adrenal cortex?", "Does the image contain a region that controls sodium reabsorption and potassium excretion through hormone secretion?", "Is there a structure that adjusts hormone output in response to changes in serum sodium or potassium levels?", "Can you see an area involved in maintaining homeostasis of sodium and potassium?", "Does the image show a region that influences blood pressure by modulating hormone release to increase sodium retention?", "Is there a structure participating in the renin-angiotensin-aldosterone system or responding to plasma potassium levels?", "Can you identify a region that increases hormone secretion in response to decreased blood volume, promoting sodium and water retention?", "Does the image include a structure that produces aldosterone in response to angiotensin II stimulation?", "Is there a region affecting fluid balance by regulating hormone levels that control renal sodium and water reabsorption?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image highlight an area within the coronary arteries, carotid arteries, or abdominal aorta that appears altered?", "Is there a visible accumulation of materials like lipids, cholesterol, calcium, or fibrous tissue?", "Can you see a disruption in the structure of an arterial wall?"], "contexual_behavior": [], "functions": ["Is there evidence of an abnormal accumulation within a blood vessel that could contribute to vascular obstruction?", "Can you observe signs of arterial stiffening or reduced compliance in the vessel wall?", "Can you identify features consistent with chronic inflammation, such as the presence of foam cells or immune cell infiltration?"]}}, "amebiasis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of a gastrointestinal condition characterized by loose or watery stools, possibly containing mucus or blood?", "Can you identify signs of a disease where the typical number of bowel movements per day ranges from 3 to 10?", "Is there visual or laboratory evidence suggesting a mildly elevated white blood cell count, such as between 10,000 and 15,000 cells/\u03bcL?", "Does the image indicate an elevated erythrocyte sedimentation rate, for example, above 30 mm/hr?", "Is there any indication of increased C-reactive protein levels, such as values exceeding 10 mg/L?", "Can you see laboratory data or findings consistent with a detectable concentration of Entamoeba histolytica antigens in stool above 1 ng/mL?", "Is there evidence of a disease process where cyst shedding in stool could last from 1 to 4 weeks?", "Does the image suggest a stool pH in the slightly acidic to neutral range, between 6.0 and 7.0?", "Can you identify a hepatic abnormality, such as an abscess, measuring between 3 and 10 cm in diameter?", "Is there any indication of liver enzyme elevation, with ALT or AST values in the range of 50 to 200 IU/L?", "Does the clinical information or visual evidence suggest a symptom duration of 2 to 4 weeks?", "Is there any sign of an incubation period for a gastrointestinal infection lasting 1 to 4 weeks?", "Can you see findings consistent with a parasite load in stool between 10^3 and 10^6 trophozoites per gram?"], "relational": ["Does the image show evidence of a condition primarily impacting the digestive or hepatic systems?", "Can you identify any damage or abnormality in the intestinal mucosa or submucosa?", "Is there visible involvement of the liver parenchyma in the image?", "Does the image display any abnormalities in the colon or liver?", "Are there signs of disease affecting the cecum, ascending colon, or rectum?", "Can you observe ulceration or necrosis in the intestinal lining?", "Is there any indication that the intestinal wall or vascular endothelium has been breached?", "Does the image suggest that the portal vein or mesenteric blood vessels are involved in a pathological process?", "Are there features suggesting secondary effects in the liver, lungs, or brain due to a gastrointestinal condition?", "Can you see any changes in the mesenteric lymph nodes or intestinal lymphatics that might indicate infection?"], "contexual_behavior": [], "functions": ["Does the image show evidence of colonic ulceration or tissue necrosis?", "Can you identify areas of abscess formation within the gastrointestinal tract or liver?", "Is there visible disruption or damage to the intestinal mucosa that could indicate impaired motility?", "Does the image reveal signs of inflammation or mucosal invasion in the colon?", "Can you see features suggestive of cytotoxic tissue damage, such as lysis or breakdown of intestinal structures?", "Is there evidence of epithelial damage or mucosal ulceration that might impair nutrient absorption?", "Does the image display infiltration of immune cells like neutrophils or macrophages in the affected tissue?", "Can you identify regions where the mucosal barrier appears disrupted or where ulcer formation is present?", "Is there any indication of hematogenous spread, such as lesions along the portal circulation or in extraintestinal sites?", "Does the liver show localized necrosis or abscesses that could result from migration of pathogenic organisms?", "Are there visual cues of apoptosis or disruption of tight junctions in the epithelial lining?", "Can you detect signs of immune evasion, such as reduced immune cell activity or absence of complement activation in affected tissues?", "Is there evidence of increased intestinal secretion or fluid accumulation that could lead to diarrhea?", "Does the image show recruitment of inflammatory cells or release of pro-inflammatory mediators in the gastrointestinal tract?", "Are there features consistent with colonic mucosal damage and excessive fluid secretion, possibly resulting in diarrhea or dysentery?"]}, "no_questions": {"contexual_properties": ["Are there several distinct areas that appear larger than typical anatomical features in the image?", "Can you identify more than one region with irregular size or appearance compared to the rest of the tissue?", "Does the image show multiple abnormal areas that are noticeably larger than surrounding structures?"], "properties": ["Are there several distinct areas that are noticeably larger than other features in the image?", "Can you identify more than one region that differs in size and appearance from the rest of the tissue?", "Does the image show multiple abnormal areas that appear larger than typical surrounding structures?"], "relational": ["Are there visible changes that could impact the nervous, digestive, or respiratory systems?", "Can you see any association between abnormal regions and arteries, veins, bile ducts, or lymphatic vessels?", "Is there visual evidence of tissue compression, invasion, or local inflammation near abnormal regions?"], "contexual_behavior": ["Are there regions where local blood vessels appear compressed or damaged, potentially reducing blood supply to surrounding tissues?", "Does the image display disruption of cellular architecture that might interfere with metabolic processes or impair nutrient exchange?", "Are there indications of persistent tissue injury or dysregulated cytokine production, reflecting an altered inflammatory response during healing?"], "functions": ["Are there regions that could be triggering an inflammatory response, possibly through the release of damage-associated molecular patterns?", "Is there evidence of reduced blood flow or vascular damage in any part of the tissue?", "Is there visual indication of nerve damage or altered sensation, such as swelling or changes in tissue appearance?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": ["Do you observe changes in cell ion content, such as features suggestive of altered sodium, potassium, or calcium levels?", "Can you see signs of mitochondrial swelling that could be related to compromised ATP production?", "Does the image show cells exhibiting swelling that could result from failure of energy-dependent ion pumps?"], "properties": [], "relational": ["Is there evidence of interaction between affected cells and components of the immune, circulatory, or lymphatic systems?", "Does the image suggest disruption of cell adhesion or barrier function, indicating altered cell-extracellular matrix interactions?", "Can you observe any changes in the heart, kidneys, or liver that might indicate early, non-lethal cellular damage?"], "contexual_behavior": ["Is there evidence of mitochondrial changes that could result from nutrient deprivation or impaired oxidative phosphorylation?", "Is there visual indication of decreased ATP generation, possibly due to low oxygen or impaired oxidative phosphorylation?", "Does the image show cells that might be experiencing swelling due to disrupted ion gradients or water influx?"], "functions": ["Can you observe features that suggest activation of repair mechanisms, such as restoration of membrane integrity or removal of damaged proteins?", "Are there visual cues that suggest the presence of stress signaling pathways or cellular adaptation mechanisms promoting survival?", "Is there evidence of increased membrane permeability or loss of selective transport in any cellular structures?"]}}, "image": {"yes_questions": {"contexual_properties": ["Does the image contain areas where features are difficult to distinguish due to reduced clarity, possibly from loss of focus or motion?", "Can you observe regions where the difference between light and dark areas is minimal, making structures hard to see?", "Is there evidence of altered proportions of primary colors, suggesting a change in color balance or white balance?", "Are there parts of the image where individual pixels are visible, indicating insufficient resolution for the display size?", "Do you notice random variations in brightness or color that could indicate increased noise, perhaps from high sensor sensitivity or low light?", "Is there a loss of fine detail that might be due to decreased pixel density or overall resolution?", "Are there areas that appear excessively bright, with loss of detail, suggesting overexposure?", "Does the image contain regions that are unusually dark, with lost detail, possibly due to underexposure?", "Can you see any unwanted visual elements or irregularities that might be artifacts from technical limitations or processing errors?", "Are there places where edges and fine details are less defined, indicating a loss of sharpness?", "Is there any visible alteration in geometric proportions, such as bending or stretching, that could be due to distortion or lens aberration?", "Do you observe regions where the overall luminance is abnormally high or low, suggesting abnormal brightness?", "Are there areas where the intensity of colors appears unusually high or low, indicating altered saturation?", "Can you spot repetitive or unexpected patterns that might result from technical faults or interference?", "Are there shadows present in locations that do not correspond to the expected direction of illumination?", "Is there a noticeable loss of fine structures or details, possibly due to compression, low resolution, or blurring?", "Does the image have a coarse or grainy texture, especially in low-light areas, indicating high noise levels?", "Are there regions where the colors appear reversed, as in a negative image, possibly due to processing errors?", "Do you see areas where the difference between light and dark is exaggerated, making features more pronounced than usual?", "Are there unexpected spots or marks present, which could be due to sensor defects, dust, or artifacts?"], "properties": ["Can you identify an object whose resolution is defined by the number of pixels along its width and height?", "Is there an entity present whose file size would depend on its resolution, color depth, and compression?", "Does the scene include something characterized by a color depth such as 8-bit or 24-bit?", "Can you find an object with an aspect ratio like 4:3 or 16:9?", "Is there a structure whose width in pixels could be specified as 800, 1920, or 3840?", "Can you see something whose height in pixels might be 600, 1080, or 2160?", "Is there an entity that could be stored in formats such as JPEG, PNG, or TIFF?", "Can you identify an object with a bit depth per channel of 8 bits, 12 bits, or 16 bits?", "Is there something whose compression ratio might range from 2:1 to 20:1 depending on its format?", "Can you observe an entity whose average brightness level could be measured on a scale from 0 (black) to 255 (white)?", "Does the scene include something whose contrast level is defined by the difference between its darkest and brightest areas?", "Is there an object whose dynamic range could be expressed in stops or decibels?", "Can you find something with a pixel density measured in dots per inch, such as 72, 150, or 300 DPI?", "Is there an entity that uses a color space like sRGB, Adobe RGB, or CMYK?", "Can you see an object whose noise level could be quantified by signal-to-noise ratio or noise variance?"], "relational": ["Does the image display any structures that could be classified as bones or muscles?", "Can you identify features belonging to the skeletal or cardiovascular systems?", "Is there evidence of anatomical regions such as the thorax or abdomen in the image?", "Does the image show tissues like connective or nervous tissue?", "Can you observe spatial orientation or continuity between anatomical structures?", "Are there cells visible that resemble neurons or adipocytes?", "Does the image include structures adjacent to major blood vessels or ligaments?", "Can you determine if the image is oriented along the sagittal or transverse plane?", "Is there a visible organ such as the heart or kidneys in the image?", "Can you identify anatomical features at the tissue or cellular level?", "Does the image show proximity or overlap between neighboring organs?", "Are muscle tissue and epithelial tissue both present in the image?", "Can you see anatomical relationships that suggest the presence of surrounding tissues?", "Is the head or limbs region represented in the image?", "Does the image capture multiple hierarchical levels, such as both organs and tissues?"], "contexual_behavior": ["Does the image show any signs of reduced clarity or sharpness that could compromise diagnostic interpretation?", "Are there visible artifacts suggesting patient movement that might obscure anatomical details?", "Can you identify the use of contrast agents enhancing the visibility of specific tissues or lesions?", "Does the image appear to have been acquired using advanced techniques such as high-resolution MRI or PET, potentially improving sensitivity for disease detection?", "Is there evidence of low resolution that could limit the detection of subtle anatomical changes important for disease monitoring?", "Does the image suggest challenges in clarity or depth that might be encountered in obese patients during image-guided interventions?", "Can you determine which imaging modality was used, and does it provide unique contrast for differentiating tissue types?", "Is there evidence of 3D reconstruction that enhances spatial orientation and anatomical detail for surgical planning?", "Does the image quality suggest a high or low signal-to-noise ratio, potentially affecting the detection of small structures such as microcalcifications?", "Are there features in the image that highlight metabolic or physiological activity, aiding in tumor localization?", "Is there anatomical overlap present that could obscure regions of interest and compromise diagnostic function?", "Does the image appear to be part of a screening program where patient age or risk factors might influence disease detectability?", "Can you observe the effects of image enhancement processing, such as increased contrast or reduced artifacts, that might improve interpretation?", "Is there evidence of metallic implants causing artifacts that could obscure underlying tissues and hinder early disease detection?", "Does the image include dynamic contrast features that enable visualization of blood flow or vessel patency for vascular assessment?", "Are there motion artifacts present that could reduce the reliability of image-based measurements?", "Can you identify the fusion of information from multiple imaging modalities that might improve diagnostic function?", "Is anatomical visualization sufficient to guide a biopsy, or does poor visualization make target localization difficult?", "Does the image suggest it is being used for therapy monitoring during rapid disease progression, possibly requiring advanced or frequent imaging?", "Are there indications that specific radiotracers were used to enhance the detection of inflammation?"], "functions": ["Does the image provide visualization of internal anatomical structures?", "Can you identify any documentation of clinical findings within the image?", "Is there evidence in the image that could support clinical decision-making?", "Does the image reveal any pathological changes or abnormal findings?", "Can you use the image to aid in disease diagnosis by identifying abnormalities?", "Is there information in the image that could be used to monitor disease progression over time?", "Does the image allow for serial comparison to assess changes in anatomy or function?", "Can the image be used to support treatment planning by localizing lesions or mapping anatomy?", "Is there anatomical detail in the image that would help in targeting areas for intervention?", "Does the image provide real-time visualization or navigation of anatomical landmarks for surgical guidance?", "Can you use the image to detect anatomical abnormalities by assessing structure or function?", "Is there evidence in the image that could be used for organ function assessment, such as functional imaging features?", "Does the image contain information relevant to physiological evaluation of an organ?", "Can the image be used for disease screening or early detection of asymptomatic conditions?", "Is there visual evidence in the image that could facilitate preventive imaging?", "Does the image allow for assessment of therapy response by comparing pre- and post-treatment findings?", "Can you use the image to monitor treatment outcomes or evaluate changes in disease status?", "Is there information in the image that could facilitate image-guided minimally invasive procedures?", "Does the image provide visualization that would assist in procedural navigation during interventions?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image suggest possible direct extension of a mass into organs like the bladder, small intestine, or abdominal wall?", "Can you see blood vessels, specifically branches of the superior or inferior mesenteric arteries, supplying an abnormal area?", "Is there evidence of abnormal tissue involving regions such as the ascending, transverse, descending, or sigmoid parts of a large intestinal structure?"], "contexual_behavior": [], "functions": ["Can you see evidence of immune cell infiltration or regions where immune surveillance might be evaded?", "Does the image show abnormal cellular arrangements that could be associated with altered signaling pathways such as Wnt/\u03b2-catenin or KRAS activation?", "Can you identify an area where the normal tissue architecture appears disrupted, suggesting local invasion or matrix degradation?"]}}, "lymphangiomatosis": {"yes_questions": {"contexual_properties": ["Does the image show any abnormal proliferation of lymphatic vessels?", "Can you identify regions with diffuse or multifocal lymphatic channel involvement?", "Is there evidence of a condition affecting multiple organs or tissues through lymphatic vessel overgrowth?", "Does the image reveal any widespread lymphatic abnormalities that could indicate a systemic disorder?"], "properties": ["Does the image show multiple masses that are diffuse throughout the tissue?", "Can you identify lesions that range in size from a few millimeters to several centimeters?", "Are there structures that appear translucent, pale, or yellowish in color?", "Is there evidence of tissue composed predominantly of lymphatic vessels and connective tissue?", "Do any of the visible lesions seem to contain fluid volumes in the milliliter to tens of milliliters range?", "Can you see masses that might have a low protein content in their fluid, similar to lymph?", "Are there areas with a cellular makeup including lymphatic endothelial cells, fibroblasts, or occasional inflammatory cells?", "Does the affected tissue appear to have lower density than surrounding normal tissue, possibly due to fluid-filled spaces?", "Are any of the lesions irregular or multiloculated in shape?", "Can you identify structures that might have a high water content, consistent with serous fluid?", "Is there evidence of tissue with low lipid content, except in regions that could contain chylous fluid?", "Do any of the lesions appear to have a soft, spongy, or cystic texture?", "Are there masses that seem to grow slowly and progressively over time?", "Can you see lesions that would be expected to have a neutral to slightly alkaline pH in their fluid?", "Are there areas with low vascularity, suggesting the presence of lymphatic rather than blood vessels?"], "relational": ["Does the image show evidence of abnormal changes within the lymphatic system?", "Can you identify any alterations in lymphatic vessels or connective tissue?", "Is there a visible abnormality affecting the respiratory or skeletal systems?", "Does the image reveal involvement of anatomical regions such as the thorax, abdomen, bones, or skin?", "Are there signs of altered lymphatic capillaries or collecting lymphatic vessels?", "Can you see any lesions present in the pleural or peritoneal cavity, or the mediastinum?", "Is there evidence of abnormal proliferation within lymphatic structures?", "Does the image show changes in organs like the lungs, liver, spleen, or bones?", "Are there visible abnormalities in tissues adjacent to blood vessels, nerves, or muscles?", "Can you identify any interactions between affected tissues and the circulatory, immune, or musculoskeletal systems?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal proliferation of vessels that could indicate multi-organ dysfunction?", "Can you identify any signs of vessel obstruction or malformation that might disrupt normal drainage?", "Is there visible fluid retention or swelling in tissues suggestive of impaired lymphatic function?", "Does the image display features consistent with impaired migration of immune cells due to blocked lymphatic pathways?", "Are there indications of excessive vessel growth or structural abnormalities affecting normal vessel function?", "Can you observe tissue swelling or edema that could result from poor lymphatic drainage?", "Is there evidence of impaired absorption of dietary fats, such as changes in intestinal structures responsible for chylomicron transport?", "Does the image suggest reduced clearance of waste products from tissues, possibly due to lymphatic dysfunction?", "Are there signs that immune surveillance might be decreased, such as limited movement of antigen-presenting cells or lymphocytes?", "Can you see features that would indicate increased interstitial fluid pressure resulting from disrupted drainage and fluid accumulation?"]}, "no_questions": {"contexual_properties": ["Can you observe a head whose size appears disproportionate to the body, possibly suggesting a recent growth spurt or unresolved swelling?", "Is there evidence of abnormal tissue growth on the head, such as tumors, cysts, or signs of overgrowth syndromes?", "Can you observe changes in head circumference that could be associated with a growth spurt, macrocephaly, or pathological swelling?"], "properties": [], "relational": ["Is there a structure composed of bones such as the frontal bone, parietal bones, or mandible?", "Is there a visible connection between a large anatomical region and the neck, possibly involving occipital condyles or cervical vertebrae?", "Does the image show a region containing both the cranium and the face?"], "contexual_behavior": [], "functions": ["Can you observe signs that might indicate enhanced physical protection for the brain, such as increased skull thickness?", "Do the upper airway structures appear affected in a way that could influence breathing or airway function?", "Are there musculoskeletal adaptations visible, such as prominent neck muscles or changes in posture, that might compensate for head size?"]}}, "colon": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify regions such as the ascending, transverse, descending, or sigmoid segments within the image?", "Is there a structure that appears adjacent to the small intestine or rectum?", "Can you see any anatomical features located near the kidneys or bladder?", "Does the image contain vessels that could correspond to the superior or inferior mesenteric arteries supplying a digestive organ?", "Is there evidence of innervation by the enteric nervous system or by fibers from the vagus or pelvic splanchnic nerves in any visible structure?", "Can you identify a region that is continuous with the rectum at its terminal end?", "Is there a visible junction where the ileum meets a larger tubular structure, possibly involving the ileocecal valve?", "Does the image show a wall composed of multiple layers such as mucosa, submucosa, muscularis propria, and serosa?", "Are there lymphatic structures present, such as mesenteric or colic lymph nodes, associated with a tubular digestive organ?", "Can you identify anatomical boundaries such as the ileocecal junction or rectosigmoid junction in the image?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for absorbing water from digested food?", "Can you identify an area involved in regulating electrolyte levels, such as sodium and chloride absorption?", "Is there a region where undigested carbohydrates might be fermented by anaerobic bacteria?", "Does the image contain a structure that compacts waste material and stores it until elimination?", "Can you see evidence of an environment that supports the proliferation of beneficial gut microbiota?", "Is there a visible area where vitamins like vitamin K and B vitamins could be absorbed after being synthesized by resident bacteria?", "Does the image show a structure that propels fecal matter toward the rectum for excretion?", "Can you identify a region involved in maintaining fluid balance through water and electrolyte reabsorption?", "Is there a structure present that contributes to immune defense via gut-associated lymphoid tissue or antimicrobial peptide production?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image contain a structure with a density close to 1.05 grams per cubic centimeter?", "Does the image show an organism with a typical lifespan of about 2 months?", "Is there a structure present with a carbohydrate content of roughly 2 to 5 percent of its dry weight?"], "relational": ["Can you see signs of egg deposition or irritation in the perianal area?", "Does the image include an organism present in the cecum, colon, or rectum?", "Can you identify an organism attached to the intestinal mucosa, potentially causing localized irritation?"], "contexual_behavior": ["Is there a structure whose survival rate would decrease in response to antiparasitic treatments such as mebendazole or albendazole?", "Can you identify a parasite that alters its behavior in response to changes in the host's gut microbiota, potentially affecting its migration and reproduction?", "Is there evidence of a parasite that increases its transmission in crowded living conditions due to higher rates of person-to-person contact?"], "functions": ["Is there evidence of an organism colonizing the colon or rectum in the image?", "Does the image show features that could be associated with direct contact transmission between hosts?", "Is there visual evidence of rapid reproduction or multiple life stages of a parasite within the intestinal lumen?"]}}, "trophozoite": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to increase in size, suggesting active nutrient uptake or growth within a host?", "Can you identify an object that shows a decrease in size, possibly indicating environmental stress or nutrient deprivation?", "Does the image contain a cell-like entity that changes shape, consistent with amoeboid movement or adaptation to its surroundings?", "Is there a structure that appears more granular, which could result from ingestion of host cell material or accumulation of metabolic byproducts?", "Can you see an object that has changed color, potentially due to pigment accumulation such as hemozoin from hemoglobin metabolism?", "Does any structure in the image display vacuoles, suggesting active feeding or endocytosis?", "Is there an entity with an altered nuclear appearance, possibly due to cell division or exposure to antiparasitic drugs?", "Can you identify a structure that has accumulated pigment, indicating digestion of host erythrocyte hemoglobin?", "Is there an object with abnormal inclusions, which might result from viral infection or exposure to toxins?", "Does any structure appear more refractile under the microscope, possibly due to fixation or accumulation of intracellular inclusions?", "Is there a cell-like object that has lost cytoplasmic clarity, suggesting degeneration or cell death?", "Can you see a structure with changes in membrane appearance, which could be due to host cell invasion or immune response?", "Is there an entity displaying increased motility-associated features, such as pseudopodia, indicating active movement or chemotaxis?", "Does any structure show altered internal composition, possibly as a result of drug exposure or metabolic adaptation?", "Is there an object that appears multinucleated, which may indicate asexual reproduction or schizogony?", "Can you identify a structure with changes in cytoplasmic density, suggesting maturation or depletion of metabolic reserves?", "Is there an entity with surface projections, possibly related to attachment to host cells or differentiation?", "Does any structure show loss of structural integrity, which could result from cell lysis or immune-mediated destruction?", "Is there an object with abnormal staining properties, potentially due to degeneration or chemical exposure?", "Can you see a structure that exhibits changes in measurable metabolic activity, possibly reflecting a transition between life cycle stages or a response to drug treatment?"], "properties": ["Does the image contain a unicellular organism measuring between 10 and 50 micrometers in length?", "Can you identify a structure with an oval or irregular, possibly amoeboid, shape?", "Is there an object that appears colorless or pale with granular inclusions under the microscope?", "Does the image show a cell with a single nucleus and a prominent central karyosome?", "Can you see cytoplasm containing food vacuoles, endoplasmic reticulum, or possibly ingested red blood cells?", "Is there a structure with moderate to high cytoplasmic granularity?", "Can you identify an object whose size corresponds to a surface area between 100 and 2000 square micrometers?", "Does the image show a cell that might exhibit amoeboid movement or flagellar motility?", "Is there evidence of a structure with high water content, making up over 70% of its mass?", "Can you see a cell with low to moderate lipid content, possibly containing small lipid droplets?", "Is there an object with low glycogen content that could be detectable with specific stains?", "Does the image include a cell whose DNA content is consistent with a single eukaryotic genome in the picogram range?", "Can you identify a structure with moderate RNA content, suggesting active protein synthesis?", "Is there a cell whose lifespan could be several hours to a few days, depending on environmental conditions?", "Does the image show a structure with variable mitochondrial content, which may differ by species?", "Can you see a membrane composed of a phospholipid bilayer with embedded proteins and glycoproteins?", "Is there evidence of enzyme activity such as proteases, hydrolases, or hexokinase within a cell?", "Can you identify a structure that tolerates a pH range between 6.0 and 8.0?", "Does the image show a cell that is typically in the picogram weight range due to its unicellular nature?", "Is there an object that usually contains one nucleus, but may occasionally have more depending on the species?"], "relational": ["Does the image show an organism that is part of the protozoan life cycle?", "Can you identify a structure that might be found in blood, stool, or intestinal fluid during infection?", "Is there a form present that could be the active, feeding stage as opposed to a dormant, infective stage?", "Does the image contain a cell that inhabits tissues such as the intestine, liver, or red blood cells?", "Can you see a structure interacting with epithelial cells, hepatocytes, erythrocytes, or immune cells?", "Is there evidence of a cell crossing barriers like the intestinal mucosa, hepatic sinusoids, or erythrocyte membrane?", "Does the image include a form related to other life cycle stages such as cyst, schizont, or merozoite?", "Can you identify a cell with internal features such as a nucleus, cytoplasm, food vacuoles, or flagella/pseudopodia?", "Is there a structure that could be associated with protozoan organisms like Plasmodium, Entamoeba, or Giardia?"], "contexual_behavior": ["Is there an organism in the image that might increase its rate of asexual reproduction when nutrients are abundant?", "Can you identify a structure that could reduce its motility in response to host immune cells or antibodies?", "Does the image show an entity that might alter its nutrient uptake during episodes of host fever?", "Is there a microorganism present that could decrease its metabolic activity when exposed to antiprotozoal drugs?", "Can you see an organism that might fail to invade host cells if its surface receptors are blocked or if the environment is unfavorable?", "Is there an object that could increase its resistance to oxidative stress when exposed to reactive oxygen species from the host?", "Does the image contain a structure that would slow its growth in a nutrient-poor environment?", "Can you identify an organism that might evade host immune responses by varying its surface antigens or secreting immunomodulatory molecules?", "Is there a microorganism that could reduce its ability to adhere to host tissues if adhesion molecules are disrupted?", "Does the image show an entity that might shift its energy metabolism to anaerobic glycolysis under low oxygen conditions?", "Is there an organism that could increase its pathogenic activity in a host with compromised immune surveillance?", "Can you see a structure that would decrease its replication rate during antimalarial treatment?", "Is there an entity that might alter its surface antigen expression to avoid recognition by the host immune system?", "Does the image show an organism that could fail to maintain osmotic balance when exposed to changes in the host environment?", "Can you identify a microorganism that might increase its secretion of proteolytic enzymes during tissue invasion to degrade the extracellular matrix?"], "functions": ["Does the image show a structure that is actively feeding or growing within a host environment?", "Can you identify an object that obtains nutrients by engulfing or absorbing material from its surroundings?", "Is there a motile and replicative stage of a protozoan parasite present in the image?", "Does the image contain a form that adheres to or penetrates host tissues?", "Can you see evidence of attachment or ingestion of host cells by a microscopic entity?", "Is there a structure that could be responsible for damaging host tissues or inducing inflammation?", "Does the image show an organism that reproduces asexually, possibly by binary fission?", "Can you identify a form that might evade the host immune response through antigenic variation or secretion of modulatory molecules?", "Is there evidence of metabolic activities such as glycolysis, fermentation, or protein synthesis in any of the observed entities?", "Does the image contain a structure that multiplies and migrates to new tissues or organs within the host?", "Can you see an organism participating in nutrient cycling by consuming host nutrients and releasing metabolic byproducts?", "Is there a form that could be transitioning to a different life stage, such as encystation, in response to environmental cues?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image suggest that the yellow discoloration has been present for days to weeks?", "Based on visible signs, can you estimate whether the severity of the condition might be mild, moderate, or severe?", "Is there any indication that the individual could have elevated liver enzyme levels such as ALT, AST, or ALP?"], "relational": ["Is there any indication of blood plasma or mucous membranes displaying unusual coloration?", "Is there any evidence of interaction between hepatic tissue and bilirubin, such as discoloration or textural changes?", "Is there a visible structure, such as the liver or gallbladder, that appears abnormal or affected?"], "contexual_behavior": [], "functions": ["Are there visual signs that could be associated with increased oxidative stress or antioxidant imbalance in the tissues?", "Are there visual clues pointing to retention of bile pigments, such as abnormal coloration of tissues?", "Can you identify any signs that might be associated with increased breakdown of red blood cells, such as pallor or other indirect indicators?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a region with moderate protein content, mainly from cellular debris and extracellular matrix proteins?", "Do you see any areas with a yellowish-white coloration?", "Is there a visible accumulation of crystalline material, particularly cholesterol crystals, in significant amounts?"], "relational": ["Does the image show evidence of obstruction in arteries or arterioles?", "Can you identify any vascular territories, such as the cerebral or peripheral arteries, that appear affected by embolic material?", "Is there evidence of compromised blood flow to the brain, kidneys, or lower limbs?"], "contexual_behavior": [], "functions": ["Is there a region in the brain where a cerebral artery appears occluded, potentially indicating a focal ischemic event?", "Does the image show microvascular obstruction, such as blocked small arterioles or capillaries, leading to localized hypoxia?", "Is there evidence of an inflammatory response, such as leukocyte accumulation, at the site of a vascular blockage?"]}}, "metastatic carcinoma prostate": {"yes_questions": {"contexual_properties": ["Does the image show evidence of a malignant neoplasm originating from a glandular organ in the male reproductive system that has spread to other tissues?", "Is there a lesion present that suggests secondary involvement by a cancer typically arising from the prostate?", "Can you identify abnormal tissue growth that may indicate the dissemination of a carcinoma from its primary site in the male pelvis?", "Does the image contain features consistent with the spread of a glandular cancer beyond its organ of origin in the male genitourinary tract?"], "properties": [], "relational": ["Does the image show evidence of disease affecting the male genitourinary system?", "Can you identify abnormalities involving the prostate gland or seminal vesicles?", "Is there visible involvement of pelvic tissues adjacent to the prostate region?", "Does the image reveal lesions or changes in the bones, particularly in the axial skeleton?", "Are there signs of abnormality in the lymph nodes, such as pelvic, obturator, internal iliac, or para-aortic nodes?", "Can you see any evidence of disease spread to the liver or lungs?", "Is there invasion of periprostatic fat, bladder wall, rectal wall, or pelvic musculature visible in the image?", "Are there features suggesting osteoblastic lesions within the skeletal system?", "Does the image show any changes in blood vessels such as the prostatic venous plexus, internal iliac veins, or Batson\u2019s plexus?", "Can you identify disruption or involvement of anatomical boundaries like the prostatic capsule, Denonvilliers\u2019 fascia, or pelvic floor muscles?", "Is there evidence of disease affecting structures adjacent to the prostate, such as the bladder, rectum, seminal vesicles, or pelvic lymph nodes?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Are there cells with decreased volume, possibly due to chronic disease or post-chemotherapy changes?", "Do any cells appear immature, potentially reflecting acute leukemia or bone marrow stress?", "Can you identify cells with increased volume, which may occur during activation or blast transformation?"], "properties": ["Are there cells present that contain cytoplasmic granules, as well as others that lack prominent granules?", "Can you observe cells with different nuclear-to-cytoplasmic ratios, such as some with a high ratio and others with a lower ratio?", "Are there cells present that would separate at a density of around 1.08 g/mL in a Ficoll-Paque gradient?"], "relational": ["Are there blood vessels or lymphatic vessels that could transport immune cells?", "Can you identify cells such as neutrophils or lymphocytes in the image?", "Is there an area of inflamed tissue where immune cells might accumulate?"], "contexual_behavior": [], "functions": ["Are there cells present that could be involved in clearing debris or aiding tissue repair after injury?", "Can you see any indication of chemotaxis or migration of cells toward an area of tissue injury or infection?", "Can you identify elements that participate in immune surveillance by monitoring tissues for abnormal or foreign cells?"]}}, "appendix": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a narrow, blind-ended tubular structure visible in the image?", "Can you identify an object that measures between 6 and 10 centimeters in length?", "Does the image show a structure with a diameter of about 6 millimeters?", "Is there a soft, pliable structure present among the tissues?", "Can you see something with a pinkish-gray color similar to other intestinal tissues?", "Is there a feature whose wall thickness appears to be around 2 to 3 millimeters?", "Does the image include a structure that could weigh between 7 and 10 grams?", "Can you identify a region that contains abundant lymphoid tissue, especially in the submucosa?", "Is there a tubular structure that receives blood supply from a branch of the ileocolic artery?", "Can you see a tissue with a water content estimated at 70 to 80 percent by weight?", "Is there a structure lined by simple columnar epithelium with goblet cells?", "Does the image show a region with moderate mucin content produced by goblet cells?", "Can you identify an object with a volume of about 1 to 2 milliliters?", "Is there a tissue whose density is close to 1.05 grams per cubic centimeter?", "Can you see a structure whose temperature would match core body temperature, around 37 degrees Celsius?", "Is there a feature with a lumen pH estimated to be neutral to slightly alkaline, around 7.0 to 8.0?", "Does the image include a structure composed of mucosal epithelial cells, lymphocytes, goblet cells, and enteroendocrine cells?"], "relational": ["Does the image show a structure that is part of the digestive system and located in the right lower quadrant of the abdomen?", "Can you identify a blind-ended tube extending from the cecum?", "Is there a structure attached to the posteromedial wall of the cecum?", "Does the image contain an object adjacent to the ileum or parietal peritoneum?", "Can you see a structure that might be supplied by a branch of the ileocolic artery?", "Is there evidence of a wall composed of mucosa, submucosa, muscularis propria, and serosa layers?", "Does the image show prominent lymphoid follicles within submucosal tissue?", "Can you identify a structure that receives innervation from the superior mesenteric plexus or the vagus nerve?", "Is there a tube-like structure surrounded by peritoneal and connective tissue in the image?"], "contexual_behavior": ["Is there a structure in the image that shows increased lymphoid activity in response to gastrointestinal infection?", "Can you identify an object whose immune function might be reduced following antibiotic use due to disrupted gut microbiota?", "Does the image show a structure that could fail to contribute to mucosal immunity in the presence of inflammation and obstruction?", "Is there evidence of tissue remodeling or depletion in lymphoid tissue that could result from chronic inflammation?", "Can you see a structure that might display decreased immune factor secretion in elderly individuals due to atrophy?", "Is there an absence of a structure that would impair the recolonization of beneficial gut bacteria after surgical removal?", "Does the image contain a structure that would be expected to have enhanced defense against pathogens during early childhood?", "Can you identify an object whose immune surveillance might be reduced in an immunocompromised state due to lymphocyte suppression?", "Is there a structure that could increase its activity in response to changes in gut microbial populations?", "Does the image show a structure that might fail to support gut immunity during severe infection due to tissue damage or overwhelming inflammation?"], "functions": ["Does the image show a structure that could serve as a reservoir for lymphoid tissue?", "Is there an object present that might contribute to immune surveillance within the gastrointestinal tract?", "Can you identify a feature that could act as a safe haven for beneficial gut bacteria?", "Does the image contain a component of gut-associated lymphoid tissue, such as one housing lymphocytes or follicles?", "Is there a structure that may facilitate the maturation of B cells or support immune education?", "Can you see an anatomical feature that might participate in the regulation of intestinal bacteria through biofilm formation?", "Is there an object that could be involved in antibody production or immune cell activation?", "Does the image include a structure that may support the proliferation of lymphocytes or the formation of germinal centers?", "Can you identify a region that might help protect against gastrointestinal infections by promoting beneficial microbiota?", "Is there a visible feature that could function as a microbial niche or reservoir for maintaining gut flora?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see a structure that might be composed of both epithelial cells and lymphocytes?", "Can you identify a structure whose weight could plausibly range from 20 to 200 grams?", "Can you see a well-defined capsule surrounding the mass, measuring between 1 and 3 millimeters thick?"], "relational": ["Does the image contain a lesion that could include thymic epithelial cells or lymphocytes?", "Can you see a structure that might involve the anterior mediastinal or paratracheal lymph nodes?", "Can you identify a mass associated with the immune or lymphatic system?"], "contexual_behavior": [], "functions": ["Can you identify a mass whose presence could lead to immunodeficiency or increased susceptibility to infections?", "Is there a structure that could compromise immune tolerance by allowing self-reactive T cells to escape into the periphery?", "Does the image show a structure that could be associated with impaired immune function or increased risk of autoimmune diseases?"]}}}
[ { "answer": "microscopic appearance of leiomyoma", "extracted_concepts": [ "microscopic appearance of leiomyoma", "bundles of normal-looking smooth muscle cells", "leiomyoma" ], "question": "what shows bundles of normal-looking smooth muscle cells?" }, { "answer": "bundles of normal-looking smooth muscle cells", "extracted_concepts": [ "smooth muscle cells", "bundles of normal-looking smooth muscle cells", "microscopic appearance", "leiomyoma" ], "question": "what does the microscopic appearance of leiomyoma show?" }, { "answer": "yes", "extracted_concepts": [ "bundles of normal-looking smooth muscle cells", "microscopic appearance", "leiomyoma" ], "question": "does microscopic appearance of leiomyoma show bundles of normal-looking smooth muscle cells?" }, { "answer": "no", "extracted_concepts": [ "smooth muscle cells", "plaque" ], "question": "does plaque show bundles of normal-looking smooth muscle cells?" } ]	["bundles of normal-looking smooth muscle cells", "microscopic appearance", "microscopic appearance of leiomyoma", "plaque", "smooth muscle cells", "leiomyoma"]	{"bundles of normal-looking smooth muscle cells": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears larger or thicker, possibly indicating adaptation to increased functional demand or hypertrophy?", "Can you identify an area where a bundle of cells appears reduced in size or thinner, which could suggest atrophy or disuse?", "Does the image show a region where a bundle of cells looks more compact, as might be seen in sustained contraction or fibrotic remodeling?", "Is there evidence of disorganization or loss of normal architecture in a cellular bundle, which could be associated with neoplasia or chronic inflammation?", "Can you observe any changes in color within a bundle of cells that might indicate ischemia, hemorrhage, or pigment deposition?", "Is there a region where the density of cells within a bundle appears increased, suggestive of hyperplasia or regeneration?", "Do you see any abnormal extracellular matrix or increased collagen deposition within a bundle, as might occur in fibrosis or chronic injury?", "Is there a bundle of cells that appears thicker than others, potentially reflecting hypertrophy or increased workload?", "Can you identify a bundle that appears thinner, possibly due to atrophy or tissue wasting?", "Does the image show any changes in the shape of cells within a bundle, which could be due to mechanical stress or pathological transformation?", "Is there evidence of collagen accumulation within a bundle, as seen in fibrotic or chronically inflamed tissue?", "Can you observe increased mitotic figures within a bundle, indicating hyperplasia or tissue repair?", "Is there a region within a bundle that appears swollen or edematous, possibly due to inflammation or vascular leakage?", "Do you see infiltration of inflammatory cells within a bundle, which could be a sign of infection, autoimmune disease, or chronic inflammation?", "Is there evidence of degeneration within a bundle, such as changes in cell structure that might result from ischemia, toxin exposure, or chronic disease?", "Can you identify areas within a bundle that appear fibrotic, as might occur after chronic injury, inflammation, or tissue repair?", "Does the image show a loss of normal organization within a bundle, which could be due to neoplastic transformation or severe injury?", "Is there a region where a bundle appears to have increased mass, possibly due to hypertrophy or hyperplasia?", "Can you observe any calcification within a bundle, which might be associated with chronic injury, dystrophic processes, or metabolic disorders?", "Is there a bundle that shows increased staining intensity, suggesting enhanced protein synthesis or accumulation of contractile proteins?"], "properties": ["Does the image show a structure that is elongated and fusiform in shape?", "Can you identify a group of closely packed cells arranged in parallel along a longitudinal axis?", "Is there a structure with a diameter between 50 and 200 micrometers and a length of several millimeters?", "Does the image contain a bundle of cells with high density and minimal extracellular space?", "Can you see a structure that appears pale pink with eosin staining?", "Is there a group of cells with elongated nuclei and abundant cytoplasm, resulting in a low nuclear-to-cytoplasmic ratio?", "Does the image show a structure with a small amount of extracellular matrix, primarily composed of collagen and elastin fibers?", "Can you identify a region where the cytoplasm is rich in actin, myosin, and intermediate filaments?", "Is there evidence of protein expression such as smooth muscle actin, desmin, or caldesmon in the image?", "Can you see a structure with moderate mitochondrial content, supporting sustained contraction?", "Does the thickness of any elongated structure in the image correspond to a diameter between 50 and 200 micrometers?", "Is there a region where the water content is likely to be approximately 70% by weight?", "Can you identify a bundle containing between 10 and 100 individual cells?"], "relational": ["Does the image show a tissue layer that could be part of the muscularis mucosae or tunica media?", "Is there a structure present that might belong to the digestive, respiratory, reproductive, cardiovascular, or urinary system?", "Can you identify a wall of an organ, such as an intestine, blood vessel, uterus, or bronchus, that appears to be composed of elongated cells arranged in bundles?", "Does the image contain a region primarily made up of smooth muscle cells, possibly with some fibroblasts or interstitial cells?", "Is there a visible layer that could be part of the esophagus, stomach, intestines, uterus, bladder, or blood vessels?", "Can you see a tissue adjacent to connective tissue, epithelial layers, nerve fibers, or blood capillaries?", "Does the image show bundles of cells surrounded by endomysium, perimysium, or loose connective tissue?", "Is there a muscular layer within a blood vessel wall, such as the tunica media of an artery or vein?", "Can you identify a region within the gastrointestinal tract, uterus, urinary bladder, bronchi, or blood vessels that appears to be composed of organized bundles of cells?", "Does the image display a layer such as muscularis propria, tunica media, myometrium, or muscularis externa within an organ wall?"], "contexual_behavior": ["Does the image show a structure that would contract more forcefully during physical activity or heightened neural stimulation?", "Is there a feature that might display reduced contractility in the presence of myopathies or chronic inflammation?", "Can you identify an area that could fail to relax properly under oxidative stress or excessive sympathetic activation?", "Does the image contain a structure that would increase its tone in response to elevated levels of hormones such as angiotensin II or endothelin?", "Is there a region that would decrease its activity during hypoxia due to impaired ATP production from reduced oxygen?", "Can you see a structure that might exhibit irregular or diminished contractions in response to inflammation?", "Is there an object that could become less responsive to neural stimulation in conditions like neuropathy or receptor desensitization?", "Does the image show a feature that would increase its contractile frequency during exercise to meet higher physiological demand?", "Can you identify a structure that might exhibit impaired function in metabolic disorders such as diabetes mellitus or mitochondrial diseases?", "Is there an area that would show enhanced relaxation after administration of vasodilators like nitric oxide donors or calcium channel blockers?", "Does the image contain a structure that would decrease its contractile strength with aging due to cellular senescence or reduced protein synthesis?", "Is there a region that might alter its contraction or relaxation patterns during electrolyte imbalances such as hypokalemia or hypercalcemia?", "Can you see a feature that could fail to maintain normal tone in chronic disease states like chronic obstructive pulmonary disease or heart failure?", "Does the image show a structure that would increase its activity in response to sympathetic stimulation via neurotransmitters like norepinephrine?", "Is there an object that might reduce its function after exposure to toxins that impair cellular metabolism or disrupt ion channels?"], "functions": ["Does the image show a structure responsible for involuntary contractions within an organ?", "Can you identify an area that might enable organ movement by altering its shape or diameter?", "Is there a feature that could regulate the diameter of blood vessels, thereby controlling vascular resistance?", "Does the image contain a structure that might control the flow of substances through a hollow organ by narrowing or widening its lumen?", "Can you see evidence of rhythmic, wave-like contractions that would propel contents along an organ, such as peristalsis?", "Is there a region that appears to provide constant, low-level contraction to support organ structure and maintain tone?", "Does the image show a structure that could respond to neural or hormonal signals by adjusting its contraction state?", "Can you identify an area involved in tissue contraction and relaxation, enabling dynamic movement in response to stimuli?", "Is there a feature that might regulate blood pressure by altering vessel diameter and affecting vascular tone?", "Does the image contain a structure capable of generating strong, coordinated contractions to assist with the expulsion of contents from organs like the bladder or uterus?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure located within the respiratory, digestive, reproductive, or endocrine systems that appears abnormal?", "Is there evidence of abnormal tissue in organs such as the lung, colon, breast, pancreas, prostate, or stomach?", "Does the image reveal the presence of stromal fibroblasts or inflammatory cells within a suspicious area?"], "contexual_behavior": [], "functions": ["Is there a mass that appears to interact with surrounding stromal cells or modify the microenvironment?", "Does the image show features that might indicate metastatic spread to distant sites?", "Is there a mass that appears to impair normal organ function by replacing healthy tissue?"]}}, "microscopic appearance": {"yes_questions": {"contexual_properties": ["Is there evidence of increased cell size that could indicate hypertrophy or cellular swelling?", "Can you identify areas where cell shapes appear abnormal, as seen in dysplasia or neoplasia?", "Does the image show regions with heightened staining intensity, suggestive of hyperchromasia or inflammation?", "Is there a reduction in the number of cells, which might be consistent with atrophy or fibrosis?", "Can you observe increased fibrous tissue, as would be expected in chronic inflammation or scar formation?", "Are there visible accumulations of fat droplets, which could be indicative of steatosis or fatty liver disease?", "Does the image display an increased number of mitotic figures, as seen in rapidly proliferating tumors or regenerating tissues?", "Is there a loss of normal tissue architecture that might suggest malignancy or severe tissue damage?", "Can you see an increased presence of inflammatory cells, as would occur in acute or chronic inflammatory conditions?", "Are there areas showing necrosis, which could be associated with infarction or severe infection?", "Does the image reveal abnormal nuclear features, as might be found in dysplasia or malignancy?", "Is there an increase in extracellular matrix, consistent with fibrosis or sclerotic diseases?", "Can you identify pigment accumulations that could indicate hemosiderosis or lipofuscinosis?", "Are there cells with decreased cytoplasmic volume, as seen in atrophy or apoptosis?", "Does the image show abnormal inclusions that might be present in viral infections or storage diseases?", "Is there evidence of increased vascularity, as would be expected in granulation tissue or tumors?", "Can you observe a loss of cell polarity, which may be characteristic of carcinoma or dysplastic epithelium?", "Are there regions showing calcification, as seen in dystrophic or metastatic calcification?", "Does the image display tissue edema, which could be present in acute inflammation or congestive states?", "Can you see disrupted cell junctions, as might occur in epithelial injury or certain genetic disorders?"], "properties": ["Does the image show structures that are round, oval, polygonal, or irregular in shape?", "Can you identify areas with pink, purple, blue, eosinophilic, or basophilic coloration depending on staining?", "Are there features in the image that appear to be within the micrometer to tens of micrometers size range?", "Do you observe cells or components arranged in clusters, sheets, single cells, or layers?", "Is the density of elements in the image best described as sparse, moderate, or dense?", "Can you see regions with fine, coarse, homogeneous, or heterogeneous granularity?", "Are there structures whose refractive index could fall between 1.35 and 1.55?", "Does the staining pattern appear uniform, patchy, granular, or peripheral in any area?", "Is the texture of observed features smooth, granular, fibrous, or homogeneous?", "Do you notice areas that are homogeneous, heterogeneous, or mixed in their appearance?", "Are inclusions absent, few, or numerous within the observed structures?", "Can you estimate if the thickness of features ranges from a few micrometers to several micrometers?", "Are the contours or borders of structures well-defined, poorly defined, or irregular?", "Do elements in the image appear transparent, translucent, or opaque?", "Is the typical number of nuclei per cell one, or are there occasionally multiple nuclei visible?"], "relational": ["Does the image allow you to distinguish between different types of tissues such as epithelial, connective, muscle, or nervous tissue?", "Can you identify cellular components like nuclei, cytoplasm, or organelles within the structures shown?", "Is there evidence of specific cell types such as neurons, erythrocytes, hepatocytes, or fibroblasts?", "Does the image show features that reflect the arrangement of cells or the organization of the extracellular matrix?", "Can you see histological structures such as glands, basement membranes, capillaries, or follicles?", "Is there a region in the image that could correspond to anatomical sites like skin, liver, kidney, or lung?", "Are there visible signs of pathological changes such as cellular atypia, necrosis, inflammation, or fibrosis?", "Does the image provide information about the organization at the cellular, tissue, or organ level?", "Can you identify features that might be used to analyze organ systems such as the nervous, digestive, respiratory, or integumentary systems?", "Is there evidence of tissue organization or cell arrangement that could help distinguish between different anatomical structures?"], "contexual_behavior": ["Does the image show evidence of cellular infiltration, edema, or tissue damage that could indicate an inflammatory response?", "Can you identify features such as cytopathic effects or immune cell infiltration that might suggest infection?", "Is there visual evidence of cellular swelling, loss of structure, or nuclear changes consistent with hypoxic conditions?", "Do blood cells in the image display variation in size, shape, or hemoglobin content that could be associated with anemia?", "Are there muscle fibers with microtears, increased nuclei, or inflammatory cells that might result from intense exercise?", "Can you see signs of neuronal loss, gliosis, or inclusion bodies that could indicate neurodegeneration?", "Is there increased cellular atypia, mitotic figures, or loss of polarity in epithelial cells suggestive of cancer progression?", "Do kidney glomeruli appear to have thickened basement membranes or mesangial expansion as seen in diabetic nephropathy?", "Is there evidence of increased goblet cells, ciliary loss, or alveolar wall destruction in lung tissue that may be linked to chronic smoking?", "Are there hepatocytes with lipid droplets or ballooning degeneration that could indicate fatty liver disease?", "Do skin layers show keratinocyte damage, sunburn cells, or increased melanin as might be seen after UV exposure?", "Is there decreased trabecular thickness or increased bone porosity in bone tissue consistent with osteoporosis?", "Can you identify coagulative necrosis, neutrophil infiltration, or loss of nuclei in cardiac muscle that may follow myocardial infarction?", "Are there increased eosinophils, mast cell degranulation, or edema among immune cells that could suggest an allergic reaction?", "Do pancreatic islets show lymphocytic infiltration or beta cell loss as seen in type 1 diabetes?", "Is there villous atrophy, crypt hyperplasia, or increased intraepithelial lymphocytes in intestinal villi that could indicate celiac disease?", "Can you observe increased collagen deposition or fibrosis in connective tissue as might occur in systemic sclerosis?", "Are there red blood cells with sickle shapes or membrane distortion that could be associated with sickle cell disease?", "Does synovial tissue display hyperplasia, pannus formation, or inflammatory infiltrate as seen in rheumatoid arthritis?", "Are there changes in cell size, secretory activity, or architectural arrangement in glandular tissue that might result from hormonal imbalance?"], "functions": ["Does the image reveal features that could assist in diagnosing a pathological condition?", "Can you identify cellular or tissue abnormalities that might indicate disease?", "Are there visible changes in cell shape, organelle distribution, or staining patterns that suggest altered cellular activity?", "Does the image display evidence of tissue dysfunction, such as degeneration, necrosis, or abnormal architecture?", "Can you observe signs of biological processes like cell proliferation, apoptosis, inflammation, or differentiation?", "Is there visual evidence of tissue regeneration or repair, such as new cell growth or restoration of normal structure?", "Does the image show infiltrating immune cells, edema, or tissue damage that would indicate an immune response?", "Can you assess whether the tissue appears healthy, inflamed, fibrotic, or necrotic based on its features?", "Are there indications of disease progression or resolution visible in the cellular or tissue characteristics?", "Can you detect abnormalities such as dysplasia, atrophy, or hypertrophy in the tissue?", "Does the image highlight features suggestive of malignancy, infection, or tissue injury?"]}, "no_questions": {"contexual_properties": ["Do any masses display a change in contrast relative to surrounding tissue, potentially reflecting changes in density or composition?", "Is there evidence of spiculated margins on any masses, suggesting malignant infiltration or desmoplasia?", "Do any masses exhibit increased border irregularity, which could be related to malignant progression or inflammation?"], "properties": ["Is there a subtle mass located in the upper outer quadrant, or elsewhere within the breast tissue?", "Can you identify a region with a low roundness or high irregularity index?", "Does the image show a mass with indistinct, spiculated, or ill-defined margins?"], "relational": ["Does the image show a region of dense or heterogeneously dense parenchyma with an irregular feature?", "Can you identify a mass-like feature that appears within the breast parenchyma or mammary glands?", "Is there a subtle irregularity that seems to abut or infiltrate surrounding glandular tissue?"], "contexual_behavior": ["Can you see a mass with altered or irregular margins that could be associated with prior surgical intervention or architectural distortion?", "Is there an area where a lesion appears more detectable, potentially due to transient changes in breast tissue during the luteal phase of the menstrual cycle?", "Is there a region in the image where dense tissue makes it difficult to distinguish the borders of a lesion?"], "functions": ["Are there subtle regions that appear denser or stiffer than the surrounding tissue?", "Is there any indication of altered vascularization or physiological changes in the breast tissue?", "Is there visual evidence of increased cellular density or abnormal tissue organization?"]}}, "microscopic appearance of leiomyoma": {"yes_questions": {"contexual_properties": ["Does the image show a region with increased cellularity, suggesting a cellular or hypercellular variant?", "Can you identify areas where the nuclei appear atypical or bizarre, as seen in symplastic or atypical changes?", "Is there evidence of necrosis, such as infarct-type or coagulative necrosis, within the tissue?", "Does the specimen display increased mitotic activity, which might indicate a cellular or atypical variant?", "Are there regions showing hyaline degeneration, a common degenerative change in larger tumors?", "Can you observe areas with calcification, possibly due to dystrophic changes in older or degenerating tissue?", "Is there visible edema or hydropic change, indicating stromal fluid accumulation?", "Does the image contain regions with abundant myxoid stroma, consistent with myxoid degeneration?", "Are there thick-walled blood vessels or signs of vascular congestion present in the tissue?", "Can you see evidence of fibrosis or collagen deposition, suggesting chronic degeneration or healing?", "Is there any hemorrhage or red degeneration visible within the sample?", "Do you observe bizarre giant cells, which may be present in atypical or symplastic variants?", "Are there areas with increased extracellular matrix, such as prominent collagen or myxoid material?", "Does the tissue show eosinophilic cytoplasm, indicating abundant smooth muscle filaments?", "Is there loss of the typical fascicular pattern, possibly due to myxoid change, edema, or degeneration?"], "properties": ["Does the image show tissue with intersecting bundles or whorled patterns of smooth muscle cells?", "Can you identify elongated, spindle-shaped cells arranged in fascicles?", "Is there evidence of small to medium, uniformly sized nuclei within the cells?", "Do the nuclei appear bland with finely dispersed chromatin?", "Is the cytoplasm of the cells pink and fibrillar, suggesting an eosinophilic appearance under H&E stain?", "Are mitotic figures rare or absent in the tissue section?", "Does the stroma appear collagen-rich, with abundant collagen fibers visible?", "Can you see closely packed cells indicating moderate to high cellular density?", "Is there an absence of necrosis in the tissue sample?", "Are small blood vessels sparsely distributed throughout the tissue?", "Does the image show minimal or no cellular atypia, with bland cytology?", "Are smooth muscle bundles arranged in intersecting or whorled fascicles?", "Is there any evidence of calcification, even if not prominent?", "Does the extracellular matrix appear to consist mainly of collagen fibers and ground substance?"], "relational": ["Does the image show a region composed primarily of smooth muscle tissue and connective tissue?", "Can you identify spindle-shaped cells or fibroblasts within the sample?", "Is there evidence of fascicles or bundles of cells with visible nuclei?", "Are small blood vessels or capillaries present within the tissue section?", "Does the sample include extracellular matrix elements such as collagen fibers, proteoglycans, or elastin?", "Can you observe a whorled pattern formed by bundles of smooth muscle cells?", "Is there a well-circumscribed margin separating a region from the surrounding myometrial tissue?", "Does the tissue display features such as low mitotic activity and absence of atypia?", "Are there connective tissue structures like fibrous stroma or collagen bundles visible?", "Is there evidence of compression of adjacent myometrial tissue at the border of the lesion?", "Can you identify regions corresponding to the myometrium, submucosa, or subserosa in the image?"], "contexual_behavior": [], "functions": ["Does the image show a lesion with well-circumscribed borders and minimal disruption of surrounding tissue?", "Can you identify a structure composed of uniform smooth muscle cells without signs of cellular atypia?", "Is there evidence of intersecting bundles of smooth muscle cells indicating expansile, non-infiltrative growth?", "Does the image contain a mass with low mitotic activity and bland cytology, suggesting low cellular proliferation?", "Can you see features that would indicate hormone responsiveness, such as the presence of estrogen or progesterone receptor expression?", "Is there visible accumulation of extracellular matrix or signs of tissue remodeling within the lesion?", "Does the structure contain small, thin-walled blood vessels consistent with moderate vascularization?", "Can you identify a mass whose microscopic features suggest a low risk of recurrence and rare spontaneous regression?", "Is there a well-organized arrangement of smooth muscle bundles that could explain distortion or dysfunction of adjacent organs due to mass effect?"]}, "no_questions": {"contexual_properties": ["Do any masses display a change in contrast relative to surrounding tissue, potentially reflecting changes in density or composition?", "Do any masses exhibit a change in shape, which could be related to tumor invasion, growth, or treatment effects?", "Does the image show an increased number of masses, possibly indicating multifocal tumor development or new lesion formation?"], "properties": ["Can you identify a region with an irregular or non-spherical shape?", "Is there a small area, measuring between 5 and 20 millimeters, that stands out from the surrounding tissue?", "Is there an area that shows only mild to moderate contrast with the surrounding tissue?"], "relational": ["Can you see any architectural distortion or asymmetric density within the mammary region?", "Is there a subtle irregularity located near axillary, intramammary, or supraclavicular lymph nodes?", "Is there a subtle area that could be associated with microcalcifications?"], "contexual_behavior": ["Is there a lesion whose borders are less clear due to increased glandular tissue or milk production, as might occur during lactation?", "Is there an area where a lesion appears more detectable, potentially due to transient changes in breast tissue during the luteal phase of the menstrual cycle?", "Is there evidence that the detection of a lesion might be impaired due to the use of digital imaging with lower resolution or contrast sensitivity?"], "functions": ["Can you identify regions with irregular borders or architectural distortion within the breast tissue?", "Are there subtle regions that appear denser or stiffer than the surrounding tissue?", "Can you identify regions that might reflect abnormal cell proliferation or dysregulated growth?"]}}, "plaque": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show an accumulation within arterial walls or dental tissues?", "Is there evidence of a structure affecting the cardiovascular system or oral cavity?", "Can you identify a deposit associated with blood vessels like the coronary or carotid arteries?", "Is there a feature adjacent to the vessel lumen or tunica media?", "Does the image contain an area with cells such as macrophages or foam cells?", "Can you see a disruption in the structure of an arterial wall?", "Is there a region interacting with the tunica intima or tunica media?", "Does the image highlight an area within the coronary arteries, carotid arteries, or abdominal aorta that appears altered?", "Can you observe changes in the endothelium, vessel lumen, or elastic lamina?", "Is there a visible accumulation of materials like lipids, cholesterol, calcium, or fibrous tissue?"], "contexual_behavior": [], "functions": ["Is there evidence of an abnormal accumulation within a blood vessel that could contribute to vascular obstruction?", "Can you identify a region within an arterial wall where lipids, inflammatory cells, or fibrous tissue appear to be accumulating?", "Does the image show narrowing of a blood vessel lumen that could restrict blood flow?", "Is there a visible structure inside an artery that might impede perfusion or increase vascular resistance?", "Can you see signs of immune cell recruitment or inflammation within a vessel wall?", "Is there an area where the vessel wall appears disrupted, possibly exposing material that could promote blood clot formation?", "Does the image suggest progression of cardiovascular disease through vessel narrowing or evidence of vascular injury?", "Can you identify features consistent with chronic inflammation, such as the presence of foam cells or immune cell infiltration?", "Is there a region where the fibrous cap of an arterial wall appears thinned or weakened, increasing the risk of rupture?", "Does the image show accumulation within a coronary artery that could reduce or block blood supply to the heart muscle?", "Is there evidence of vessel wall erosion or rupture that might lead to hemorrhage or thrombosis?", "Can you observe signs of arterial stiffening or reduced compliance in the vessel wall?", "Does the image reveal a blockage or rupture in a blood vessel that could result in tissue ischemia, such as in the heart or brain?"]}, "no_questions": {"contexual_properties": ["Does the image show cavities within a structure, which could result from infections like tuberculosis or abscess formation?", "Is there evidence of increased mucus production, as might be seen in chronic bronchitis, asthma, or cystic fibrosis?", "Is there a structure that appears heavier or denser, which could indicate fluid, blood, or inflammatory exudate accumulation as seen in pneumonia or edema?"], "properties": ["Is there a structure present that would have a soft, spongy, and elastic texture?", "Can you identify a structure that contains specialized cells such as alveolar epithelial cells, endothelial cells, fibroblasts, or macrophages?", "Is there an object present that contains structural proteins, enzymes, and surfactant proteins as part of its composition?"], "relational": ["Is there an organ surrounded by the rib cage or diaphragm?", "Does the image contain a structure that could be adjacent to the liver?", "Can you identify multiple lobes within a single organ in the image?"], "contexual_behavior": ["Is there an indication of altered ventilation-perfusion matching, which could be related to changes during sleep?", "Does the image show signs of inflammation, ciliary dysfunction, or tissue damage that might be associated with smoking exposure?", "Does the image suggest increased work of breathing, such as recruitment of accessory muscles, possibly due to airway obstruction?"], "functions": ["Does the image show a structure responsible for exchanging gases between air and blood?", "Can you identify a structure that contributes to vocalization by supplying airflow to the larynx?", "Does the image show an organ that filters small blood clots or air bubbles in the vascular network?"]}}, "smooth muscle cells": {"yes_questions": {"contexual_properties": ["Is there evidence in the image of cells that have increased in size, possibly due to increased workload or hormonal stimulation?", "Can you identify cells that appear smaller, which might suggest reduced mechanical load or denervation?", "Does the image show cells with altered shapes, potentially indicating migration or response to injury?", "Are there cells that appear hypertrophic, possibly as a result of chronic mechanical stress or exposure to growth factors?", "Can you see cells that look atrophic, perhaps due to prolonged inactivity, ischemia, or loss of trophic signals?", "Is there visual evidence of increased cytoplasmic protein content in certain cells, suggesting hypertrophy or increased synthetic activity?", "Do you observe an increased number of cells in regions that might have experienced injury, inflammation, or growth factor stimulation?", "Are there cells with abnormal inclusions, which could indicate storage diseases or degenerative disorders?", "Does the image show cells with altered contractile protein composition, possibly due to phenotypic switching or disease states?", "Can you spot multinucleated cells, which might result from pathological conditions or cell fusion events?", "Is there evidence of increased extracellular matrix production, such as in areas of tissue remodeling, fibrosis, or vascular disease?", "Do you notice differences in cell coloration that could be due to histological staining and variations in protein or lipid content?", "Are there cells that have lost structural integrity, possibly as a result of necrosis, apoptosis, or severe injury?", "Can you identify regions with increased cell numbers, suggesting proliferation during development, repair, or in response to growth factors?", "Are there areas where cell numbers appear reduced, potentially due to apoptosis, necrosis, or degenerative diseases?", "Does the image show evidence of altered calcium levels in cells, such as during contraction, signaling, or in pathological states?", "Are there cells that appear more rigid, possibly due to fibrosis, increased extracellular matrix deposition, or cytoskeletal changes?", "Can you see cells that seem more elastic, perhaps as a result of tissue remodeling or increased expression of elastic proteins?", "Are there cells containing vacuoles, which might indicate cellular injury, autophagy, or degenerative processes?", "Do you observe changes in mitochondrial content within cells, possibly reflecting adaptation to altered energy demands, hypoxia, or disease?"], "properties": ["Does the image show cells that are spindle-shaped or fusiform in appearance?", "Can you identify structures that are approximately 100 micrometers in length and 5 micrometers in diameter?", "Is there evidence of cells with a single, centrally located nucleus?", "Do you see cells that appear pale eosinophilic or pinkish with hematoxylin and eosin staining?", "Are there structures that could contain moderate amounts of mitochondria distributed throughout the cytoplasm?", "Can you identify cells likely to contain contractile proteins such as actin, myosin, tropomyosin, calmodulin, and desmin?", "Is there evidence of alpha-smooth muscle actin or smooth muscle myosin heavy chain within any cells?", "Do you observe cells that might have an actin to myosin ratio between 10:1 and 15:1?", "Are there structures that could contain moderate amounts of glycogen but low lipid content?", "Can you see cells that are likely to have a water content of about 70\u201380% of their total mass?", "Is there evidence of cells with a density close to 1.05 grams per cubic centimeter?", "Do you observe cells that are likely to have a lifespan ranging from several years to decades depending on their tissue location?"], "relational": ["Does the image show a tissue layer that could be part of the muscularis or tunica media?", "Can you identify a structure that might be found in the walls of the uterus, intestines, or blood vessels?", "Is there a visible layer that could be responsible for regulating the diameter of a vessel?", "Does the image contain a structure that could form a sphincter or a peristaltic band?", "Can you see evidence of connective tissue types such as endomysium or perimysium surrounding muscle fibers?", "Is there a layer that appears to be the middle portion of a blood vessel wall?", "Does the image show features consistent with vasoconstriction or vasodilation?", "Can you identify circular or longitudinal layers within the gastrointestinal tract?", "Are there regions that could correspond to the muscularis mucosae or muscularis externa?", "Does the image show a tissue layer located just beneath an epithelial lining, separated by a basement membrane?", "Are there structures that might be found in the walls of bronchi or the urinary bladder?", "Can you see areas where muscle layers are organized to support peristaltic movement?", "Is there evidence of other cell types, such as fibroblasts or endothelial cells, in close proximity to muscle fibers?", "Does the image contain tissue organization suggesting a subepithelial location for a muscle layer?", "Are there visible features indicating the presence of an extracellular matrix associated with muscle tissue?"], "contexual_behavior": ["Does the image show a structure that would increase its contractile activity in response to elevated vasoconstrictor signaling, as seen in hypertension?", "Is there an object present whose contraction would decrease after administration of calcium channel blockers or vasodilators?", "Can you identify a structure that might fail to relax properly in the presence of airway hyperresponsiveness, as occurs in asthma?", "Does the image contain a component that enhances peristalsis after a meal due to gastrointestinal hormones and neural input?", "Is there a structure that would reduce its tone during systemic vasodilation, such as in shock?", "Can you see an object that might show impaired contraction due to altered signaling pathways, as is observed in diabetes mellitus?", "Is there a structure that could increase its proliferation in response to inflammatory cytokines and growth factors, contributing to vascular remodeling in atherosclerosis?", "Does the image include a component whose contractility could be altered by hormonal changes during pregnancy?", "Can you identify a structure that would lose responsiveness to neural stimulation if the autonomic nerve supply were damaged, as in neuropathy?", "Is there an object that would increase its contraction during cold exposure due to sympathetic activation?", "Does the image show a structure that would decrease its activity in response to nitric oxide via the cGMP pathway?", "Can you see a component that might exhibit abnormal relaxation due to dysregulated enteric nervous system signaling, as in irritable bowel syndrome?", "Is there a structure that would increase its contractile response in the presence of pro-inflammatory mediators, as seen during inflammation?", "Does the image contain an object that could fail to maintain vascular tone due to excessive vasodilator production, as in sepsis?", "Can you identify a structure that would alter its function by shifting to anaerobic metabolism during hypoxia?", "Is there a component that could show increased calcium sensitivity in diseases such as pulmonary hypertension or asthma?", "Does the image show a structure that would reduce its contractile force with aging due to decreased receptor sensitivity and structural changes?", "Can you see an object that would change its phenotype from contractile to synthetic after vascular injury?", "Is there a structure that would increase contraction during stress in response to elevated catecholamine levels?", "Does the image contain a component whose function could be impaired by genetic defects affecting contractile proteins, as in muscular dystrophy?"], "functions": ["Does the image show a structure responsible for involuntary contractions in internal organs?", "Can you identify a tissue that generates rhythmic movements to propel contents through hollow organs such as intestines or blood vessels?", "Is there evidence of a structure that regulates vessel diameter to control blood flow?", "Does the image contain a component involved in adjusting vascular resistance and modulating blood pressure?", "Can you see a tissue coordinating wave-like contractions to move food along the gastrointestinal tract?", "Is there a structure that produces powerful contractions during labor or menstruation?", "Does the image show a component that regulates airway diameter and controls airflow to the lungs?", "Can you identify a tissue that contracts to expel urine from the bladder or relaxes to allow bladder filling?", "Is there a structure involved in adjusting pupil size in response to changes in light intensity?", "Does the image contain a tissue that responds to hormones such as oxytocin or adrenaline by altering its contractile activity?", "Can you see a component forming the functional part of a sphincter, enabling controlled opening and closing of passageways?", "Is there evidence of a tissue maintaining baseline contraction in blood vessels to ensure stable blood flow?", "Does the image show a structure contributing to wound healing by proliferating and migrating to repair damaged tissue?", "Can you identify a tissue facilitating reproductive functions such as sperm transport or ejaculation?", "Is there a component that adapts to physiological changes by modifying its contractile properties or proliferating in response to stimuli?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image contain an object with a smooth or irregular surface texture?", "Is there an area that appears avascular, hypovascular, or hypervascular?", "Does the image show a lesion that appears to have grown slowly or has a variable growth rate?"], "relational": ["Does the image show a structure situated in regions like the neck, lungs, breast, or subcutaneous tissue?", "Is there an embedded structure adjacent to blood vessels, nerves, or surrounding parenchyma?", "Does the image contain a mass that is part of a larger anatomical structure such as an organ, lobe, or gland?"], "contexual_behavior": ["Is there evidence of loss of homeostasis in a localized area, possibly due to infection and immune cell infiltration?", "Can you identify a region showing signs of abnormal cell proliferation, as might occur in pathological or neoplastic processes?", "Is there evidence of reduced secretory function in a region where fibrosis or increased extracellular matrix deposition has replaced functional cells?"], "functions": ["Does the image show a localized mass that could indicate abnormal tissue growth or a response to injury?", "Can you see an area that might compromise organ function by obstructing normal tissue pathways or altering physiological processes?", "Is there a visible feature that might disrupt blood flow, alter secretion, or impede normal tissue interactions at its location?"]}}, "leiomyoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a mass located within an organ of the reproductive, gastrointestinal, or urinary system?", "Can you identify a lesion arising from tissue composed of smooth muscle?", "Is there a structure adjacent to the endometrium, myometrium, or serosa visible in the image?", "Does the image contain a mass primarily made up of smooth muscle cells or fibroblasts?", "Can you see a tumor-like structure in the uterus, small intestine, esophagus, or skin?", "Is there a growth originating from the smooth muscle layer of the uterus?", "Does the image show a mass arising from layers such as the myometrium, muscularis propria, or tunica media?", "Can you identify a lesion with blood supply from vessels like the uterine artery or branches of the internal iliac artery?", "Is there a structure surrounded by a pseudocapsule or dense collagen fibers?", "Does the image show a mass located in the uterine body, cervix, or broad ligament?"], "contexual_behavior": ["Does the image show a structure whose growth might accelerate during pregnancy due to increased sex steroid hormones?", "Is there evidence of a mass that could be more responsive to estrogen and progesterone during the reproductive years?", "Can you identify a lesion that would likely reduce in size after menopause when ovarian hormone production declines?", "Does the image contain a structure that could impair uterine contractility during menstruation by disrupting normal myometrial function?", "Is there a mass that might alter its vascular supply under hypoxic conditions by promoting angiogenesis or vascular remodeling?", "Can you see a lesion that would decrease its metabolic activity in response to hormonal therapy such as GnRH agonists?", "Is there a structure that could increase extracellular matrix production in response to inflammation through fibroblast activation?", "Does the image show a mass that might distort the endometrial cavity and affect hemostasis during episodes of heavy menstrual bleeding?", "Is there a lesion whose proliferative activity would be reduced after treatment with GnRH agonists due to hormonal suppression?", "Can you identify a structure that might increase local estrogen production in obese individuals because of enhanced aromatase activity in adipose tissue?", "Does the image contain a mass that could impair fertility by altering the uterine environment, including endometrial receptivity and embryo implantation?", "Is there evidence of a lesion that increases angiogenic activity during rapid growth phases to support tissue expansion?", "Can you see a structure that might decrease its responsiveness to progesterone in the context of chronic inflammation due to altered receptor expression?", "Is there a mass that could alter uterine blood flow during physical exertion by compressing adjacent vessels and modifying vascular resistance?", "Does the image show a lesion that might increase cytokine secretion in response to tissue injury, contributing to local inflammation and tissue remodeling?"], "functions": ["Does the image show a benign growth originating from smooth muscle tissue?", "Is there evidence of a mass that could disrupt the normal contractile function of the uterus?", "Can you identify a structure that might distort the architecture of the myometrium?", "Does the image contain a lesion that could increase or irregularize menstrual bleeding by altering the endometrial surface or vascular supply?", "Is there a mass that could interfere with embryo implantation or contribute to infertility by distorting the uterine cavity?", "Can you see a structure that might compress or increase blood vessels, potentially altering local blood flow?", "Is there evidence of tissue displacement, compression, or hypertrophy of adjacent smooth muscle fibers?", "Does the image show a mass that could express hormone receptors and modify the local hormonal environment in the uterus?", "Is there a lesion that might cause pelvic pain or pressure symptoms by exerting a mass effect on surrounding pelvic structures?", "Can you identify a structure that could contribute to bulk-related pelvic symptoms such as discomfort, urinary frequency, or constipation?", "Does the image show a mass that could compromise normal uterine function, including menstruation, fertility, or contractility?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image provide a view of organs like the lungs or heart?", "Does the image show air-filled spaces that could correspond to the lungs or gastrointestinal tract?", "Is it possible to evaluate bone alignment or joint spaces based on the image?"], "contexual_behavior": ["Are there signs of cellular damage in rapidly dividing tissues, such as bone marrow or gastrointestinal epithelium, that could be attributed to increased radiosensitivity?", "Is there a lack of clear visualization of soft tissue injuries or tumors, indicating limited sensitivity for non-calcified masses?", "Does the image show reduced clarity or obscured structures that could be due to fluid accumulation such as pleural effusion or edema?"], "functions": ["Is there a way to assess disease progression by comparing this image with previous ones?", "Does the image appear to guide a medical procedure, such as catheter placement or orthopedic intervention?", "Can you see any signs of abnormal tissue growths that could support a cancer diagnosis?"]}}}
[ { "answer": "inclusion bodies", "extracted_concepts": [ "inclusion bodies" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "inclusion bodies" ], "question": "does this image show inclusion bodies?" }, { "answer": "no", "extracted_concepts": [ "inclusion bodies", "atrophy" ], "question": "does atrophy show inclusion bodies?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "antitrypsin" ], "question": "is antitrypsin present?" }, { "answer": "stomach", "extracted_concepts": [ "stomach" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "stomach" ], "question": "is stomach present?" }, { "answer": "no", "extracted_concepts": [ "cranial artery" ], "question": "is cranial artery present?" }, { "answer": "cytomegalovirus", "extracted_concepts": [ "cytomegalovirus" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "cytomegalovirus" ], "question": "is cytomegalovirus present?" }, { "answer": "no", "extracted_concepts": [ "acute lymphocytic leukemia" ], "question": "is acute lymphocytic leukemia present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "stomach", "extracted_concepts": [ "stomach" ], "question": "what is present?" }, { "answer": "cytomegalovirus", "extracted_concepts": [ "cytomegalovirus" ], "question": "what is present?" } ]	["antitrypsin", "acute lymphocytic leukemia", "cranial artery", "inclusion bodies", "atrophy", "stomach", "gastrointestinal", "cytomegalovirus", "gastrointestinal system"]	{"antitrypsin": {"yes_questions": {"contexual_properties": ["Does the image show evidence of a protein whose levels rise in the blood during acute inflammation or infection?", "Can you identify signs of a molecule that decreases in concentration in cases of hereditary deficiency or severe liver disease?", "Is there visual evidence of protein accumulation within hepatocytes that could indicate intracellular retention due to a genetic variant?", "Does the image reveal abnormal protein aggregates or polymerization that might result from specific mutations?", "Can you observe features consistent with protein misfolding, such as the presence of the Z or S variant?", "Is there any indication of altered glycosylation patterns in a plasma protein, possibly due to liver dysfunction or congenital disorders?", "Does the image suggest a protein acting as an acute-phase reactant, with increased concentration during inflammatory states?", "Can you detect reduced plasma levels of a protein that might be linked to SERPINA1 mutations?", "Is there evidence of a protein rendered inactive by proteolytic cleavage or oxidative inactivation?", "Does the image show abnormal electrophoretic mobility of a serum protein, possibly due to structural variants or post-translational modifications?", "Can you identify signs of enhanced proteolysis or rapid degradation of a protein associated with certain genetic variants?", "Is there visual evidence of altered isoforms of a protein, potentially due to allelic or splice variants?", "Does the image suggest complete absence of a plasma protein, as might occur in cases of homozygous deficiency or null mutations?", "Can you see increased protein presence in urine, which could indicate nephrotic syndrome or glomerular injury?"], "properties": ["Is there a protein present that has a molecular mass close to 52 kilodaltons?", "Can you identify a molecule with an amino acid sequence encoded by the SERPINA1 gene?", "Does the image show a protein whose normal plasma concentration ranges from 0.9 to 2.0 grams per liter?", "Is there evidence of a molecule with an isoelectric point around pH 4.7?", "Can you see a structure characterized by a serpin fold with three beta-sheets and nine alpha-helices?", "Is there a protein present with a typical half-life of 4 to 5 days in the bloodstream?", "Does the image indicate glycosylation at three asparagine residues with complex N-linked oligosaccharides?", "Is there a molecule that carries a net negative charge at physiological pH?", "Can you identify a protein that is stable at physiological temperatures but denatures above 60\u00b0C?", "Is there a structure that is highly soluble in water under physiological conditions?", "Does the image show a protein with a normal serum level range of 90 to 200 mg/dL in adults?", "Is there a purified protein in solution that appears colorless?", "Can you observe a molecule whose secondary structure is mainly composed of beta-sheets and alpha-helices?", "Is there evidence of a genetic variant corresponding to the M allele of the SERPINA1 gene?", "Does the image suggest a protein with a melting temperature of approximately 62\u00b0C?"], "relational": ["Does the image show an organ involved in the respiratory or circulatory systems that could be affected by a deficiency in a serpin family protein?", "Is there a structure in the image that is responsible for synthesizing proteins in the serpin family, such as antithrombin or alpha-1 antichymotrypsin?", "Can you identify tissue in the image where hepatocytes are present and may be producing a protein found in blood plasma?", "Does the image include anatomical features such as alveoli or blood vessels that interact with proteins protecting against protease-mediated damage?", "Is there evidence of a structure that could be affected by the absence of a protein produced in the liver and important for lung health?", "Can you see compartments like the bloodstream or extracellular space where a protein from the serpin family might be distributed?", "Does the image contain features of the immune or respiratory systems that rely on protection from protease activity?", "Is there a visible relationship between the liver and lungs in the image that could be relevant to a deficiency in a protein synthesized by hepatocytes?", "Can you identify body fluids such as blood plasma or interstitial fluid where a serpin family protein might be present?"], "contexual_behavior": [], "functions": ["Is there evidence of a molecule that acts as a serine protease inhibitor to protect tissues from enzymatic degradation?", "Can you identify a component that regulates protease activity by binding to and inactivating enzymes such as neutrophil elastase?", "Does the image suggest the presence of a factor that neutralizes proteolytic enzymes released during inflammation to prevent tissue damage?", "Is there a feature indicating protection of lung tissue from breakdown by inhibiting neutrophil elastase and preserving alveolar walls?", "Can you observe any sign of modulation of inflammation through limitation of protease-mediated tissue injury?", "Is there evidence of a stable complex formed with neutrophil elastase, indicating inhibition through a suicide substrate mechanism?", "Does the image show preservation of alveolar integrity or prevention of chronic lung damage, suggesting maintenance of respiratory health?", "Is there a marker indicating control of excessive protease activity during immune responses, contributing to immune regulation?", "Can you detect signs of protection against emphysema by preventing enzymatic destruction of lung tissue?", "Is there an indication of an acute phase protein whose levels increase during systemic inflammation, participating in the acute phase response?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you observe features consistent with increased glycolytic activity or a high metabolic rate in any cell population?", "Does the image suggest the presence of cells with aneuploid or hyperdiploid DNA content?", "Can you see evidence of coarse or vesicular chromatin patterns in any of the cells?"], "relational": ["Can you see an epithelial layer lacking hormone receptor expression?", "Is there a structure within the integumentary, respiratory, or reproductive system that appears to have regenerative properties?", "Does the image contain cells or regions that express basal cytokeratins?"], "contexual_behavior": [], "functions": ["Is there a structure indicating production of antimicrobial peptides or modulation of local immune responses?", "Is there evidence of cell-cell adhesion, extracellular matrix interaction, or paracrine signaling coordinating tissue function?", "Does the image suggest the presence of cells with stem-like properties that could be implicated in tumor initiation or cancer progression?"]}}, "acute lymphocytic leukemia": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a disease affecting the hematopoietic system?", "Can you identify abnormal proliferation of lymphoid precursor cells such as lymphoblasts?", "Is there infiltration of tissues like bone marrow, lymph nodes, spleen, or the central nervous system visible?", "Does the image suggest disruption of normal hematopoiesis within the bone marrow?", "Are there signs of organ involvement such as the liver, spleen, lymph nodes, or brain being affected?", "Can you observe alterations in blood components like white blood cells, red blood cells, or platelets?", "Is there abnormality in lymphoid structures such as lymph nodes, thymus, or spleen?", "Does the image include anatomical sites commonly used for diagnosis, such as bone marrow, peripheral blood, or cerebrospinal fluid?", "Is there evidence of a process originating from lymphoid progenitor cells within the lymphatic system?", "Can you see malignant cells present in body fluids like blood or cerebrospinal fluid?"], "contexual_behavior": [], "functions": ["Does the image show evidence of rapid proliferation of immature lymphoid cells infiltrating bone marrow or other tissues?", "Can you identify signs of suppressed production of normal blood cells, such as reduced numbers of mature blood cell types?", "Is there visual indication of immune system compromise, such as a decreased presence of functional lymphocytes?", "Does the image reveal replacement of normal bone marrow elements with abnormal cells?", "Can you see an accumulation of nonfunctional lymphoid cells that do not appear to participate in immune responses?", "Is there evidence of reduced numbers of mature white blood cells, suggesting increased susceptibility to infections?", "Does the image show decreased platelet numbers or features consistent with impaired blood clotting?", "Can you identify signs of reduced red blood cell production, such as features suggestive of anemia?", "Is there visual evidence of abnormal expansion of lymphoblasts in blood or tissue samples?", "Does the image suggest overcrowding of the bone marrow by malignant cells, leading to suppression of healthy blood cell development?", "Are there features indicating multi-organ impact, such as signs of hypoxia, hemorrhage, or infection, that could result from bone marrow failure?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify anatomical variations such as an anomalous right coronary artery or an interarterial course of a coronary vessel?", "Are there any signs of ischemic changes in the myocardium of the left ventricle or left atrium that could result from an abnormal arterial origin?", "Does the image suggest an absence of the typical connection between the left coronary artery and the aorta?"], "contexual_behavior": [], "functions": ["Is there visual evidence of collateral vessels forming between the right coronary artery and the left coronary territory, indicating compensatory mechanisms?", "Can you identify any features suggesting impaired cardiac perfusion due to low-pressure, low-oxygen blood flow?", "Is there evidence of features that could impair the heart\u2019s response to stress or increased workload, potentially increasing the risk of arrhythmias or sudden cardiac arrest?"]}}, "cranial artery": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the circulatory system within the head?", "Can you identify a vessel supplying blood to regions such as the scalp, meninges, brain, or face?", "Is there a blood vessel that could originate from the internal or external carotid artery, or the vertebral artery?", "Does the image contain a vessel that gives rise to branches like the middle meningeal artery or the ophthalmic artery?", "Can you see any veins, such as cerebral veins or meningeal veins, that are associated with arteries in the cranial region?", "Is there a vessel located near cranial bones such as the skull, temporal bone, or sphenoid bone?", "Does the image show a structure providing blood to brain tissue, scalp, dura mater, or facial muscles?", "Can you identify a vessel responsible for supporting the metabolic needs of the brain?", "Is there a structure that is protected by the skull or meninges?", "Does the image show a vessel forming connections with other arteries, such as those in the Circle of Willis or the facial artery?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for delivering arterial blood to the brain?", "Can you identify a vessel involved in supplying oxygen and nutrients to cranial tissues?", "Is there evidence of an arterial network that forms part of the Circle of Willis?", "Does the image contain a structure that regulates cerebral blood flow by adjusting its diameter?", "Can you see a vessel that helps maintain consistent perfusion and supports brain homeostasis?", "Is there a structure that responds to changes in blood pressure through mechanisms like myogenic responses?", "Does the image show a vessel contributing to waste removal via the blood-brain barrier and venous return?", "Can you identify a structure that supports neural activity by providing glucose and oxygen for synaptic transmission?", "Is there a vessel visible that participates in thermoregulation by modulating blood flow within the brain?", "Does the image contain a structure that could initiate collateral circulation to protect brain tissue during ischemia?"]}, "no_questions": {"contexual_properties": ["Can you see any changes in amniotic fluid volume that could be associated with fetal distress or oligohydramnios?", "Does the image reveal any clots located between the placenta and the uterine wall?", "Does the image show evidence of significant separation between the placenta and the uterine wall, possibly leading to hemorrhage?"], "properties": ["Does the image suggest a partial or complete separation of the placenta from the uterine wall?", "Is there evidence of a coarse or uneven texture in a region near the maternal side of the placenta?", "Can you see a dark red or maroon area suggestive of accumulated blood near the placenta?"], "relational": ["Does the image show any abnormality involving the placenta and the uterine wall?", "Can you observe any impact on fetal structures like the chorionic villi or umbilical cord?", "Is there evidence of premature detachment of the placenta from the uterus?"], "contexual_behavior": ["Can you observe loss of barrier function against toxins at the maternal-fetal interface, potentially increasing fetal exposure due to detachment of a protective structure?", "Can you identify signs of increased maternal blood loss during labor that might result from separation of a structure responsible for fetal support?", "Is there evidence of impaired gas exchange between mother and fetus, such as reduced surface area for oxygen and carbon dioxide transfer, due to separation of a critical interface?"], "functions": ["Can you identify signs of reduced placental blood flow, such as detachment or vascular disruption?", "Are there visual cues of physiological responses such as uterine tenderness or signs suggestive of shock?", "Can you see alterations in placental structure that might disrupt hormone production or impair waste removal?"]}}, "inclusion bodies": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show any intracellular structures that are between 0.2 and 2 micrometers in diameter?", "Can you identify spherical or irregularly shaped objects within the cells?", "Are there refractile, eosinophilic, or basophilic features visible under the microscope?", "Do you see any dense aggregates that might consist primarily of proteins?", "Is there evidence of intracellular bodies that could contain misfolded or overexpressed proteins?", "Are there structures present that are denser than the surrounding cytoplasm?", "Can you identify objects with a higher refractive index than the cytoplasm, possibly in the range of 1.38 to 1.42?", "Are there intracellular features that could have a protein content exceeding 90% of their dry mass?", "Do you observe any structures that might contain less than 5% nucleic acids or minimal lipids?", "Are there objects within the cells that likely have negligible carbohydrate content?", "Does the image reveal highly electron-dense aggregates when viewed with electron microscopy?", "Can you see intracellular bodies that appear amorphous or partially crystalline?", "Is there variation in the number of these structures per cell, ranging from a few to several dozen?", "Do any cellular inclusions stain positively with eosin, hematoxylin, or Congo red?", "Are there visible aggregates that appear insoluble in aqueous environments?", "Can you identify structures that would remain stable across a pH range of 4 to 10?", "Are there features that could withstand temperatures up to 60\u201370\u00b0C without disintegration?"], "relational": ["Does the image show a subcellular structure within neurons or hepatocytes?", "Can you identify any features located inside the nucleus or cytoplasm of a cell?", "Is there evidence of intranuclear or cytoplasmic inclusions within the depicted cells?", "Does the image contain structures found in nervous tissue, liver tissue, or epithelial tissue?", "Can you see any objects interacting with the cytoskeleton or nuclear envelope?", "Are there visible features that could be classified as Lewy bodies, Negri bodies, Mallory bodies, or viral inclusions?", "Does the image display subcellular objects within the cytoplasmic matrix or nuclear matrix?", "Is there a structure present that is commonly associated with diseases such as Parkinson\u2019s disease, rabies, cytomegalovirus infection, or alcoholic liver disease?", "Can you identify inclusions within cells from organs like the brain, liver, skin, or kidney?"], "contexual_behavior": ["Does the image show evidence of structures that accumulate rapidly during the early or peak phases of a viral infection?", "Can you identify features that might indicate protein overproduction or acute infection within cells?", "Is there visual evidence of cellular components that could impair normal protein processing due to aggregation or misfolding?", "Does the image display signs consistent with proteostasis disruption, such as aggregated material overwhelming cellular quality control systems?", "Are there structures whose number appears increased in regions showing oxidative damage or cellular stress?", "Can you observe features that might suggest protein aggregation under oxidative stress conditions?", "Is there evidence of disrupted cellular metabolism or mitochondrial dysfunction, possibly linked to neurodegenerative disease?", "Do you see aggregates that could interfere with metabolic enzyme function or indicate neurodegeneration?", "Are there regions where misfolded proteins seem to overwhelm sequestration mechanisms, suggesting proteostasis failure or chaperone deficiency?", "Can you identify structures that physically obstruct organelles or disrupt their normal activities during cellular stress?", "Is there visual evidence of spatial disruption or organelle dysfunction within stressed cells?", "Do you observe features that might form more frequently in response to toxin exposure, such as those induced by protein misfolding or proteasome inhibition?", "Are there accumulations that could indicate impaired lysosomal degradation, as seen in lysosomal storage disorders?", "Can you identify regions where impaired autophagy or lysosomal dysfunction might reduce the clearance of aggregated material?", "Is there variation in the composition or appearance of aggregates that could reflect different pathological states or disease conditions?", "Do you see evidence of altered protein content within cellular inclusions depending on disease state?", "Are there features that might contribute to impaired cell signaling, such as sequestration of signaling molecules or disruption of signaling pathways?", "Can you observe a reduction in the size of aggregates, possibly indicating successful protein refolding or chaperone activity?", "Is there visual evidence of cell cycle disruption or hindered cell division, potentially due to interference with mitotic machinery?", "Do you see aggregates that could impact neuronal function, particularly those resembling alpha-synuclein accumulations as seen in Parkinson\u2019s disease?", "Are there cells lacking visible aggregates, possibly due to defects in protein aggregation pathways or chaperone deficiencies?", "Can you identify features that might exacerbate cellular dysfunction during chronic inflammation, such as sustained stress responses or impaired cellular activities?"], "functions": ["Does the image show intracellular structures that could be sites of protein aggregation?", "Can you identify any features that suggest the sequestration of misfolded or damaged proteins within a cell?", "Is there evidence of cellular adaptation to stress, such as the compartmentalization of aberrant proteins?", "Does the image contain structures that might act as repositories for insoluble or aggregated proteins?", "Can you see any cellular components that could be involved in protein quality control or proteostasis?", "Are there visible features that might indicate the isolation of toxic protein species to protect the cell?", "Does the image show any signs of cellular protection mechanisms against proteotoxic stress?", "Can you identify structures that may interact with degradation pathways like autophagy or the ubiquitin-proteasome system?", "Is there evidence of protein turnover, such as sites for temporary storage and degradation of abnormal proteins?", "Does the image contain hallmarks associated with neurodegenerative disease, such as abnormal protein aggregation?", "Can you see any features that might reflect the cell's response to pathological conditions or stress?", "Are there structures present that could reduce cellular toxicity by isolating harmful protein aggregates?", "Does the image show any intracellular bodies that may impair cell function if present in excess?", "Can you identify any features that suggest the maintenance of cellular homeostasis through protein sequestration?"]}, "no_questions": {"contexual_properties": ["Does the image reveal abnormal surface texture, possibly indicating dysplasia or metaplasia?", "Are erosions present that might be caused by NSAID injury or infectious colitis?", "Are strictures apparent that could be associated with Crohn\u2019s disease or post-surgical changes?"], "properties": ["Can you tell if the illumination intensity in the image is within the range of 100,000 to 300,000 lux?", "Does the image exhibit low to moderate noise levels, suggesting good sensor quality and lighting?", "Does the depth of field in the image seem to be between 3 mm and 50 mm?"], "relational": ["Is the perspective consistent with direct internal visualization for diagnostic or therapeutic purposes?", "Are there identifiable landmarks such as the pylorus, vocal cords, ileocecal valve, or ureteral orifice present?", "Does the view include anatomical features consistent with organs such as the esophagus, stomach, colon, bronchi, or bladder?"], "contexual_behavior": [], "functions": ["Does the image appear to guide or facilitate minimally invasive procedures by showing precise navigation of instruments within the body?", "Can you see visual cues that might help evaluate the effectiveness of a previous treatment or intervention?", "Can you identify any abnormalities such as lesions, tumors, or signs of inflammation in the internal tissues shown?"]}}, "atrophy": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears reduced in size, possibly due to prolonged disuse or aging?", "Can you identify tissue that looks thinner or less dense, which might suggest a period of malnutrition or reduced stimulation?", "Is there evidence of decreased organ weight or mass, potentially resulting from cell shrinkage or cell loss?", "Does the image reveal tissue that appears structurally degraded or resorbed, indicating possible thinning?", "Can you see a region where muscle mass seems diminished, perhaps due to immobilization, denervation, or cachexia?", "Is there a visible area where normal cells seem to be replaced by connective or fatty tissue?", "Does the image suggest a reduction in cell number, possibly due to increased apoptosis or necrosis?", "Is there a structure that appears more fragile or depleted, which could be due to loss of supportive matrix and cellular content?", "Can you observe a change in tissue color that might be caused by decreased blood supply or fatty replacement?", "Does the image show decreased tissue density, possibly from loss of cellular or extracellular components?", "Is there evidence of disrupted normal architecture in an organ, suggesting structural changes from tissue loss?", "Can you identify increased fat infiltration in a tissue, where muscle or parenchymal cells may have been replaced by adipocytes?", "Does the tissue texture appear altered, such as being softer or more fibrotic than expected?", "Is there a region where function-related biomarkers might be reduced due to loss of functional tissue mass?", "Does the image display visible shrinkage of a tissue or organ, indicating significant volume loss?"], "properties": ["Does the image show a tissue or organ that appears smaller or shrunken compared to what would be expected for its type?", "Can you identify a structure that looks pale or yellowish and possibly translucent?", "Is there evidence of a region with noticeably reduced thickness or volume?", "Does any tissue in the image appear to have a softer, flaccid, or friable texture?", "Can you see an area where the tissue mass or weight seems diminished by a significant proportion?", "Is there a structure that could have lost up to half of its original size or weight?", "Does the image suggest a gradual reduction in tissue size that might have occurred over weeks or months?", "Can you identify a region where the density of cells appears increased, even though the overall number of cells seems reduced?", "Is there visual evidence of increased connective tissue or fibrosis within a tissue, possibly at the expense of normal cellular elements?", "Does any area appear to have altered composition, such as more collagen or less glycosaminoglycan content?", "Can you see signs that suggest a decrease in protein or water content within a tissue?", "Is there a region where individual cells seem smaller than usual, possibly due to reduced cytoplasmic or organelle content?"], "relational": ["Does the image show a reduction in the size or mass of a tissue that could be muscle, brain, liver, or kidney?", "Can you identify any changes in structures belonging to the musculoskeletal, nervous, or endocrine systems that might indicate a loss of tissue?", "Is there evidence of decreased bulk in skeletal muscle, cerebral cortex, or cardiac muscle?", "Does the image reveal alterations in muscle fibers, neurons, or adipocytes that suggest a degenerative process?", "Can you see a region where skeletal muscle tissue appears diminished in mass or strength?", "Is there a visible reduction in the size of the limbs, brain, or heart?", "Does the image display features such as cell shrinkage, loss of tissue mass, or fewer cellular organelles?", "Are there signs of thinning or weakening in connective tissues like tendons, ligaments, or fascia?", "Can you observe structural changes in organs such as the brain, heart, skeletal muscle, or thymus?", "Is there evidence of altered interaction between tissues and the nervous, circulatory, or immune systems that could be due to tissue degeneration?"], "contexual_behavior": [], "functions": ["Does the image show a tissue or organ with visibly reduced size and diminished function compared to normal?", "Can you identify an area where there is evidence of tissue loss or functional decline?", "Is there a structure that appears less efficient or impaired in its normal function?", "Does the image suggest decreased protein content or increased signs of cellular breakdown, such as catabolism or apoptosis?", "Can you see a region where muscle mass appears reduced, potentially leading to weakness or impaired movement?", "Is there evidence of organ dysfunction or cellular loss in any of the depicted tissues?", "Does any area in the image appear to have lower metabolic activity, such as reduced cellular density or hypometabolism?", "Can you identify features that might indicate altered hormonal regulation, neural input, or increased proteolysis in a tissue?", "Is there a region where the capacity for tissue repair or regeneration seems compromised, such as a reduced pool of viable cells?", "Does the image show an area with decreased nutrient uptake or altered metabolic characteristics?", "Can you see evidence of weakened tissue resilience or impaired recovery from injury or stress in any structure?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify areas where cells seem enlarged or shrunken, suggesting changes like hypertrophy or atrophy?", "Are there cells with dilated endoplasmic reticulum visible in the image?", "Is there evidence of increased cell numbers in any region, which could indicate hyperplasia?"], "relational": ["Does the image contain regions such as the myocardium, bronchi, or liver parenchyma that might show adaptive changes?", "Does the image show any tissue that could be epithelial, muscle, or connective in nature?", "Can you see anatomical features such as blood vessels, alveoli, or renal tubules that could display signs of adaptation?"], "contexual_behavior": [], "functions": ["Does the image display signs of recovery or restoration of normal cellular function after damage?", "Is there evidence that cells are surviving in adverse conditions, potentially contributing to chronic disease or malignancy?", "Is there visual evidence of tissue maintaining integrity by balancing cell survival, proliferation, and death?"]}}, "stomach": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify an organ that is adjacent to the liver or pancreas?", "Is there a structure positioned near the spleen or transverse colon?", "Does the image display regions such as the cardia, fundus, body, antrum, or pylorus?", "Can you see evidence of blood supply from arteries like the left gastric or right gastric artery?", "Is there a structure that could be innervated by the vagus nerve or fibers from the celiac plexus?", "Does the image show a connection between the esophagus and another organ via a cardiac orifice?", "Can you identify a junction where the esophagus delivers ingested material to another structure?", "Is there a visible connection to the duodenum through a pyloric sphincter?", "Does the image reveal layers such as mucosa, submucosa, muscularis externa, or serosa in a wall of an organ?", "Can you see a lining that might contain parietal cells, chief cells, mucous cells, or enteroendocrine cells?", "Is there evidence of support or anchoring by the lesser omentum, greater omentum, or gastrosplenic ligament?", "Does the image show lymphatic structures such as gastric lymph nodes, gastroepiploic lymph nodes, or celiac lymph nodes near an organ?", "Can you identify an organ that interacts with both the esophagus and duodenum during digestion?", "Is there a structure in the image that could be involved in transferring contents from the esophagus to the small intestine?"], "contexual_behavior": [], "functions": ["Does the image show an organ responsible for storing ingested food before it enters the small intestine?", "Can you identify a structure that initiates the process of digestion?", "Is there an object that regulates the gradual passage of food into the small intestine?", "Does the image contain a structure that secretes gastric juices to aid in digestion?", "Can you see an organ that mechanically breaks down food through muscular contractions?", "Is there evidence of a structure that forms chyme by mixing food with digestive secretions?", "Does the image include a feature that controls the release of food via a sphincter at the junction with the small intestine?", "Can you identify a region where digestive enzymes like pepsinogen are secreted for protein breakdown?", "Is there a structure that produces hydrochloric acid to denature proteins and activate digestive enzymes?", "Does the image show an area where parietal cells might be present?", "Can you see a structure that creates an acidic environment to destroy ingested pathogens?", "Is there evidence of coordinated muscular contractions that mix and churn food with secretions?", "Does the image contain a region where substances such as alcohol or medications could be absorbed directly into the bloodstream?", "Can you identify an organ that releases hormones like ghrelin to regulate appetite?", "Is there a structure involved in the production of gastrin for hormonal regulation of digestion?", "Does the image show a region where pepsin is activated to hydrolyze proteins?", "Can you see an area that provides antimicrobial defense through high gastric acidity?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the lesion appear to have a slow growth rate based on its characteristics?", "Does the image show cells with a fine and evenly distributed chromatin pattern?", "Is there a mass with a pale tan or grayish-white coloration?"], "relational": ["Is there a mass surrounded by dura mater or the pituitary capsule?", "Can you see an abnormality involving the anterior lobe (pars distalis) of the pituitary gland?", "Is there evidence of expansion or involvement of the sella turcica?"], "contexual_behavior": ["Does the image suggest a lesion whose secretory behavior could change during pregnancy?", "Is there evidence of a mass within the sella turcica that could be compressing or destroying healthy pituitary tissue?", "Is there a structure that might show reduced responsiveness to hypothalamic signals due to receptor deficiency?"], "functions": ["Is there evidence of a mass that could cause reduced or absent secretion of pituitary hormones, potentially leading to endocrine dysfunction?", "Is there a structure that could explain growth impairment or developmental delay due to reduced growth hormone secretion?", "Can you see a lesion that might interfere with the normal feedback mechanisms between the hypothalamus, pituitary, and target glands?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": ["Are there changes in density\u2014such as increased sclerosis, lytic lesions, or calcification\u2014visible in the region of two adjacent foramina?", "Can you detect calcification within or around two adjacent foramina, as might occur in metabolic bone disorders or after chronic inflammation?", "Can you observe increased size variation between two adjacent foramina, potentially reflecting genetic diversity or skeletal dysplasia?"], "properties": ["Are there two structures with a cross-sectional area of about 800\u2013900 mm\u00b2 each?", "Is there a pair of foramina with an estimated volume of around 2,000\u20132,500 mm\u00b3 each?", "Does the image display two openings in bone that appears pale yellowish-white, consistent with cranial bone?"], "relational": ["Are there openings near the jugular foramen or hypoglossal canal visible in the image?", "Does the image show an opening connected to the dura mater or pia mater?", "Does the image show features located in the posterior region of the cranial cavity?"], "contexual_behavior": ["Can you identify herniation of the cerebellar tonsils that could partially or completely block openings at the craniospinal junction, as seen in Chiari malformation?", "Can you identify any masses, congenital anomalies, or edema that might obstruct the passage at the craniospinal opening and impair neural function?", "Is there a visible reduction in cerebrospinal fluid flow or signs of increased intracranial pressure that might suggest compression or obstruction at the level of the foramen magnum?"], "functions": ["Is there a visible conduit for cerebrospinal fluid to flow between the cranial and spinal subarachnoid spaces?", "Can you see openings that maintain anatomical and functional continuity between the cranial cavity and the vertebral canal?", "Does the image show features involved in balancing intracranial and spinal pressure by permitting cerebrospinal fluid movement and accommodating pressure changes?"]}}, "cytomegalovirus": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of infection in organ systems like the respiratory, gastrointestinal, or nervous system?", "Can you identify cells such as epithelial cells or monocytes that may be targeted by a viral pathogen?", "Is there a visible abnormality in tissues like the salivary glands, placenta, lungs, liver, or retina?", "Does the image depict anatomical barriers such as the mucosal epithelium or blood-brain barrier that might be involved in viral entry?", "Can you see any indication of body fluids such as blood or saliva that could harbor a viral agent?", "Is there a structure, such as the salivary glands or kidneys, that could serve as a reservoir for a persistent infection?", "Does the image include blood vessels or lymphatic vessels that could facilitate the spread of an infectious agent?", "Can you identify immune cells or tissues that might be susceptible to viral infection or immune evasion?", "Is there evidence of involvement in anatomical sites commonly affected in congenital infections, such as the brain or spleen?", "Does the image suggest dissemination of infection through pathways like hematogenous or lymphatic spread?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see regions that could correspond to both rough and smooth forms of a membranous network?", "Can you identify a feature present in eukaryotic cells such as hepatocytes or neurons?", "Does the image display a compartment that is connected to the cytosol and the Golgi apparatus?"], "contexual_behavior": ["Can you identify an area where chaperone activity might increase in response to heat shock to protect proteins from denaturation?", "Is there evidence of increased autophagy activity during nutrient deprivation to support cellular survival?", "Can you see a structure that would activate the unfolded protein response when misfolded proteins build up under stress?"], "functions": ["Does the image contain an area where molecular chaperones could facilitate protein folding?", "Can you see a region where ribosomes might be attached for mRNA translation?", "Is there an organelle present that participates in calcium signaling or interacts with signaling proteins?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show abnormal cells interacting with or invading blood vessels or capillaries?", "Is there evidence of abnormal cells utilizing lymphatic vessels or lymph nodes to reach distant sites?", "Are there visible abnormalities in regions commonly targeted by secondary tumors, such as the liver, lungs, bones, brain, or lymph nodes?"], "contexual_behavior": [], "functions": ["Does the image show signs of cachexia or systemic metabolic effects, such as tissue wasting or loss of normal tissue mass?", "Is there visual evidence of tissue structures being breached, such as the basement membrane or extracellular matrix?", "Does the image suggest the presence of cells that may be resisting apoptosis or exhibiting survival advantages?"]}}}
[ { "answer": "source of granulomatous colitis", "extracted_concepts": [ "granulomatous colitis" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "granulomatous colitis" ], "question": "does this image show source of granulomatous colitis?" }, { "answer": "no", "extracted_concepts": [ "cachexia", "granulomatous colitis" ], "question": "does cachexia show source of granulomatous colitis?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "artery" ], "question": "is artery present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "colon" ], "question": "is colon present?" }, { "answer": "no", "extracted_concepts": [ "placenta" ], "question": "is placenta present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" } ]	["cachexia", "artery", "colon", "gastrointestinal", "granulomatous colitis", "gastrointestinal system", "placenta"]	{"cachexia": {"yes_questions": {"contexual_properties": ["Does the image show evidence of rapid weight loss in an individual with a chronic illness?", "Can you identify signs of muscle wasting or reduced muscle mass in the context of persistent inflammation?", "Is there visible reduction in fat stores or signs of increased energy expenditure?", "Does the image suggest a decreased body mass index due to loss of both muscle and fat?", "Can you observe changes in body composition, such as depletion of lean muscle mass and adipose tissue?", "Is there evidence of muscle weakness or atrophy that could indicate functional decline?", "Does the image suggest possible malnutrition, such as signs of protein catabolism or reduced serum albumin?", "Are there visual cues indicating ongoing systemic inflammation, such as features associated with elevated inflammatory markers?", "Can you see signs of reduced appetite or decreased caloric intake, possibly related to disrupted hunger signaling?", "Does the skin appear thinned or pale, suggesting loss of subcutaneous fat and muscle?", "Is there evidence of decreased bone density or osteopenia, possibly due to chronic inflammation or nutritional deficiencies?", "Can you identify features that might indicate increased protein breakdown or proteolysis?", "Are there signs of anemia, such as pallor, that could be due to low hemoglobin in chronic disease?", "Does the image suggest an altered fat-to-muscle ratio, with muscle mass declining more rapidly than fat stores?", "Can you observe visible loss of subcutaneous tissue or wasting in the context of advanced chronic illness?"], "properties": [], "relational": ["Does the image show evidence of changes in both the musculoskeletal and digestive systems?", "Can you identify any structural alterations in skeletal muscle tissue or adipose tissue?", "Is there visible atrophy of skeletal muscles or subcutaneous fat?", "Does the image suggest a reduction in lean body mass or fat mass?", "Are there signs of progressive loss or dysfunction in skeletal muscle?", "Can you see evidence of significant depletion of adipose tissue?", "Is there an indication of altered total body water in the depicted subject?", "Does the image show organs such as the liver, heart, pancreas, or gastrointestinal tract that might be affected by a wasting process?", "Are there visible changes in cellular components like myocytes, adipocytes, or immune cells?", "Can you observe disruption at multiple structural levels, such as cells, tissues, and organs?", "Is there evidence of the immune or endocrine systems being affected in the image?", "Does the image suggest involvement of cardiac muscle tissue in a degenerative process?", "Are there signs of fibroblast activity or tissue remodeling in the depicted structures?"], "contexual_behavior": [], "functions": ["Does the image show evidence of severe weight loss or muscle atrophy?", "Can you identify signs of reduced physical performance or functional decline?", "Is there visual evidence of increased energy expenditure or metabolic imbalance, such as pronounced thinness or muscle wasting?", "Does the image suggest enhanced muscle proteolysis or reduced muscle protein synthesis, as indicated by muscle loss?", "Can you see signs of adipose tissue depletion or fat loss, such as reduced subcutaneous fat?", "Is there any indication of appetite suppression or anorexia, such as visible signs of poor nutritional status?", "Does the image suggest elevated inflammation, such as features consistent with chronic illness or immune activation?", "Can you identify features that might indicate protein breakdown or muscle catabolism?", "Is there visual evidence of weakness, reduced mobility, or impaired endurance?", "Does the image suggest hormonal imbalance, such as signs of reduced anabolic or increased catabolic hormone effects?", "Can you see features that might indicate immunosuppression or chronic inflammation?", "Is there evidence of malabsorption or nutrient deficiency, such as signs of poor gastrointestinal function or wasting?", "Does the image show signs of organ dysfunction or reduced tissue reserve, such as atrophy of organs or tissues?", "Can you identify visual cues of fatigue or reduced exercise tolerance, such as a frail appearance or inability to perform physical tasks?"]}, "no_questions": {"contexual_properties": ["Can you see compression at the cranial base opening that might result from excessive bone deposition or premature fusion of cranial sutures?", "Is there evidence of decreased diameter at the opening in the skull base suggestive of abnormal bone development as seen in skeletal dysplasias?", "Does the image show narrowing at the cranial base that could be seen in conditions like achondroplasia or congenital craniosynostosis?"], "properties": ["Can you identify bone tissue in the region of a cranial foramen with density values typical of cortical bone (1200\u20131600 Hounsfield units)?", "Does the image suggest that the narrowing of a cranial opening is present from early development and remains stable after skeletal maturity?", "Does the image display a constricted bony opening with thickened margins at the skull base?"], "relational": ["Can you identify a region where the tectorial membrane or alar ligaments would attach to a visibly narrowed bony margin?", "Is there a constricted connection between the cranial cavity and the vertebral canal at the level of the first cervical vertebra?", "Does the image reveal a bony constriction at the cranial base that is smaller than expected for a typical opening in this location?"], "contexual_behavior": [], "functions": ["Is there visual evidence of compression affecting cranial nerves IX, X, or XI as they exit the skull, which could result in swallowing or speech deficits?", "Does the image show evidence of neural or vascular structures being compressed, potentially leading to neurological deficits?", "Can you see any compromise of arterial or venous blood flow that might lead to ischemia or venous congestion in the brain?"]}}, "artery": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the cardiovascular system?", "Can you identify a vessel with distinct layers such as tunica intima, tunica media, and tunica adventitia?", "Is there a vessel present that supplies blood to organs like the brain, heart, or kidneys?", "Does the image contain a structure that transports blood away from the heart?", "Can you see a vessel that is not a vein but is involved in circulation?", "Is there evidence of different types of vessels such as elastic arteries, muscular arteries, or arterioles?", "Can you identify a small vessel that connects larger vessels to capillary beds?", "Is there a major blood vessel visible in the neck, thorax, abdomen, or limbs?", "Does the image show a vessel adjacent to nerves, veins, or lymphatic vessels?", "Can you see a structure that originates from the heart and distributes oxygenated blood?", "Is there a vessel that gives rise to branches such as collateral arteries or terminal branches?"], "contexual_behavior": ["Is there a structure in the image that might show signs of impaired blood flow regulation, as could occur in severe vascular disease?", "Can you identify an object that would constrict more in response to cold exposure due to increased sympathetic activation?", "Does the image contain a structure that would dilate during physical exercise to meet increased metabolic demand?", "Is there an object that could fail to maintain normal blood pressure during shock due to loss of vascular tone?", "Can you see a structure that might exhibit reduced elasticity or plaque formation, as seen in atherosclerosis?", "Is there an object that would increase blood delivery to tissues during inflammation through vasodilation?", "Does the image show a structure that could have reduced oxygen transport capacity in hypoxic conditions?", "Can you identify something that might lose its ability to respond to hormonal signals in cases of receptor dysfunction or chronic vascular disease?", "Is there a structure that could have its function impaired by plaque buildup, leading to reduced lumen diameter?", "Does the image contain an object that would increase its role in thermoregulation during fever by adjusting blood flow to the skin?", "Can you see a structure that might reduce nutrient delivery in diabetes due to microvascular complications?", "Is there an object that could alter its blood flow pattern during stress because of sympathetic nervous system activation?", "Does the image show a structure that might fail to supply adequate blood during a spasm caused by smooth muscle contraction?", "Can you identify an object that would increase its compliance during pregnancy in response to hormonal changes?", "Is there a structure that could reduce its ability to buffer pressure changes in hypertension due to chronic stiffening?"], "functions": ["Does the image show a structure responsible for transporting blood away from the heart?", "Can you identify an object that propels oxygen-rich blood under high pressure through muscular and elastic walls?", "Is there a structure involved in delivering oxygen to tissues via capillary networks?", "Does the image contain something that helps regulate blood pressure through elastic recoil and contractility?", "Can you see an object that carries nutrient-rich blood to support cellular metabolism?", "Is there a structure that indirectly supports waste removal by delivering blood to sites of exchange?", "Does the image show a vessel that can adjust its diameter in response to neural or chemical signals?", "Can you identify a structure whose walls contain smooth muscle for controlling blood flow and resistance?", "Is there an object involved in thermoregulation by altering blood flow to the skin?", "Does the image include a vessel that distributes hormones from endocrine glands to target tissues?", "Can you see a structure that ensures continuous delivery of oxygen and nutrients to support organ function?", "Is there a vessel that adapts during physical activity by dilating to increase blood flow to muscles?", "Does the image show a structure essential for maintaining adequate tissue perfusion and circulatory homeostasis?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a detection system with a dynamic range spanning 10,000- to 1,000,000-fold in fluorescence signal?", "Is there evidence of a device sensitive enough to detect fluorescent signals corresponding to as few as 10 to 100 molecules of equivalent soluble fluorochrome?", "Can you see an apparatus that operates with a flow rate between 10 and 60 microliters per minute?"], "relational": ["Is there a specimen present that might originate from peripheral blood, bone marrow, or lymph node aspirate?", "Is there a compartment such as peripheral circulation, bone marrow cavity, or a lymphoid organ represented in the image?", "Does the image contain cells such as lymphocytes, monocytes, granulocytes, or stem cells?"], "contexual_behavior": [], "functions": ["Does the image include a technique that analyzes cell cycle phases by quantifying DNA content with fluorescent dyes?", "Can you identify a process that assesses immune cell function by measuring cytokine production or activation markers?", "Does the image depict a way to measure cell proliferation using DNA-binding dyes or nucleotide analogs like BrdU or EdU?"]}}, "colon": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify regions such as the ascending, transverse, descending, or sigmoid segments within the image?", "Is there a structure that appears adjacent to the small intestine or rectum?", "Can you see any anatomical features located near the kidneys or bladder?", "Does the image contain vessels that could correspond to the superior or inferior mesenteric arteries supplying a digestive organ?", "Is there evidence of innervation by the enteric nervous system or by fibers from the vagus or pelvic splanchnic nerves in any visible structure?", "Can you identify a region that is continuous with the rectum at its terminal end?", "Is there a visible junction where the ileum meets a larger tubular structure, possibly involving the ileocecal valve?", "Does the image show a wall composed of multiple layers such as mucosa, submucosa, muscularis propria, and serosa?", "Are there lymphatic structures present, such as mesenteric or colic lymph nodes, associated with a tubular digestive organ?", "Can you identify anatomical boundaries such as the ileocecal junction or rectosigmoid junction in the image?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for absorbing water from digested food?", "Can you identify an area involved in regulating electrolyte levels, such as sodium and chloride absorption?", "Is there a region where undigested carbohydrates might be fermented by anaerobic bacteria?", "Does the image contain a structure that compacts waste material and stores it until elimination?", "Can you see evidence of an environment that supports the proliferation of beneficial gut microbiota?", "Is there a visible area where vitamins like vitamin K and B vitamins could be absorbed after being synthesized by resident bacteria?", "Does the image show a structure that propels fecal matter toward the rectum for excretion?", "Can you identify a region involved in maintaining fluid balance through water and electrolyte reabsorption?", "Is there a structure present that contributes to immune defense via gut-associated lymphoid tissue or antimicrobial peptide production?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure that could have a phosphorus concentration of about 17 to 18 percent by weight?", "Is there a dome-shaped, convex structure visible in the image?", "Does the image show a region that might be composed mainly of hydroxyapatite, a crystalline form of calcium phosphate?"], "relational": ["Can you see a region that overlies the meninges and the cerebral cortex?", "Does the image include a region adjacent to the intracranial compartment or the subgaleal space?", "Does the image show anatomical landmarks like the bregma, sagittal suture, or coronal suture?"], "contexual_behavior": [], "functions": ["Can you identify a region that provides support for the scalp and overlying soft tissues?", "Is there a region that contains spongy bone with spaces housing bone marrow involved in blood cell production?", "Does the image contain a surface that serves as an attachment site for cranial muscles involved in head movement or facial expression?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show an object with a circumference of about 55 to 58 centimeters?", "Can you identify an object that appears off-white or pale ivory due to mineralized bone tissue?", "Is there a structure present that could measure approximately 22 cm in length, 17 cm in width, and 14 cm in height?"], "relational": ["Are there distinguishing features such as multiple cavities or complex articulations present?", "Is there a region visible that could correspond to the cranium or facial skeleton?", "Can you see any foramina, such as the optic canal or jugular foramen?"], "contexual_behavior": [], "functions": ["Does the image show a framework that supports sensory organs such as the eyes or ears?", "Is there a bony framework shaping the forehead, cheeks, or jaw?", "Does the image include features like the mandible or maxilla that enable mastication?"]}}, "granulomatous colitis": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a disease process affecting the digestive system?", "Is there any abnormality involving the large intestine, particularly the colon?", "Can you identify changes that extend through multiple layers such as the mucosa, submucosa, or muscularis propria of the colon?", "Are there lesions containing immune cell types like macrophages, epithelioid cells, multinucleated giant cells, or lymphocytes?", "Is there visible granulomatous inflammation within the colonic mucosa?", "Are anatomical structures adjacent to the colon, such as pericolonic fat, mesentery, or serosa, affected or altered?", "Can you see involvement of lymphatic structures such as mesenteric lymph nodes or colonic lymphatic vessels near the affected area?", "Is there evidence of vascular supply from branches of the superior or inferior mesenteric arteries to the affected region?", "Are there signs of secondary involvement in the terminal ileum, perianal region, or skin?", "Do the rectum or sigmoid colon appear to be the primary sites of abnormality in the image?"], "contexual_behavior": [], "functions": ["Does the image show evidence of chronic inflammation or granuloma formation within the colon?", "Can you identify areas where immune cells such as macrophages or T cells appear to be persistently activated in colonic tissue?", "Is there visible mucosal damage or signs of increased epithelial permeability in the colon?", "Does the image suggest impaired nutrient absorption due to mucosal injury or architectural distortion of the colon?", "Are there features indicating ongoing or persistent inflammatory processes in the colonic tissue?", "Can you observe recruitment or clustering of immune cells like macrophages, lymphocytes, or neutrophils at sites of colonic inflammation?", "Is there evidence of delayed mucosal healing or impaired epithelial regeneration in the colon?", "Does the image suggest alterations in the local gut environment that could be associated with dysbiosis or microbiota dysregulation?", "Are there visible granulomas formed by aggregates of activated macrophages and other immune cells in the colon?", "Can you detect changes in colonic motility or transit, such as features that might correspond to diarrhea or constipation?", "Is there evidence of increased local production of pro-inflammatory cytokines, such as TNF-alpha, IL-1, or IL-6, in the colonic tissue?", "Does the image reveal signs of tissue remodeling, fibrosis, or structural changes in the wall of the colon?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a region in the heart that lies between the endocardium and the epicardium?", "Do all four heart chambers in the image contain a common muscular component?", "Is there a structure adjacent to both the endocardium and the cardiac valves?"], "contexual_behavior": [], "functions": ["Can you identify tissue that supports oxygen delivery by maintaining effective blood flow to other organs?", "Can you see evidence of compensatory mechanisms, such as thickened muscle or structural changes, that protect the heart from overload?", "Does the image show a region that could regulate blood pressure by adjusting the force and rate of contraction?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": ["Are there visible features suggesting damage or disease within the brain section?", "Is there evidence of localized changes in the tissue that could indicate pathology?", "Does the slide display any regions that differ in color or texture compared to normal brain tissue?"], "properties": ["Does the slide reveal a single abnormal area or multiple discrete foci within the brain tissue?", "Can you observe regions with an average diameter between 2 mm and 20 mm?", "Are there clusters of inflammatory cells such as lymphocytes, macrophages, or neutrophils present within the abnormal regions?"], "relational": ["Can you identify adjacent structures such as ventricles in proximity to the abnormal area?", "Does the image display neural, glial, or vascular tissue within the area of interest?", "Is there any indication of connections to structures like the spinal cord, cranial nerves, or pituitary gland in the image?"], "contexual_behavior": ["Can you see signs of inflammation that could impair neuronal energy metabolism?", "Is there any indication of compromised endothelial integrity that might disrupt blood-brain barrier function in the context of autoimmune disease?", "Is there a region that might indicate impaired neurotransmitter release due to hypoxic conditions?"], "functions": ["Does the slide display abnormalities that might correspond to compromised motor control or coordination?", "Can you observe any features that might correspond to reflex impairment, such as areas potentially responsible for hyperreflexia or hyporeflexia?", "Are there visible features that might be associated with impaired memory or learning processes?"]}}, "placenta": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the reproductive system?", "Can you identify tissues such as chorionic villi or decidua basalis?", "Is there a visible connection between a structure and the umbilical cord?", "Does the image display fetal blood vessels linked to another structure?", "Can you see an interaction between a structure and the uterine wall?", "Is there evidence of maternal blood sinuses adjacent to another tissue?", "Are uterine arteries, umbilical arteries, or the umbilical vein supplying a visible structure?", "Does the image include membranes like the amnion or chorion associated with another structure?", "Can you observe a conduit for fetal blood flow connecting to a larger tissue mass?", "Is there a structure located within the uterine cavity or endometrial lining?", "Can you identify layers such as syncytiotrophoblast or cytotrophoblast in a tissue?", "Does the image show a barrier or layers separating maternal and fetal blood?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for transferring nutrients and gases between maternal and fetal blood?", "Can you identify an object that supports fetal development by supplying oxygen and removing metabolic waste?", "Is there a feature present that enables the movement of glucose, amino acids, fatty acids, or vitamins from mother to fetus?", "Does the image contain a structure that facilitates oxygen diffusion to the fetus and carbon dioxide removal from fetal blood?", "Can you see an object that transfers waste products such as urea from the fetus to the maternal circulation?", "Is there a structure involved in the secretion of hormones like hCG, progesterone, or estrogen to support pregnancy?", "Does the image include a barrier that provides immune protection for the developing fetus?", "Can you identify a structure that regulates the transfer of maternal antibodies, such as immunoglobulin G, to the fetus?", "Is there an object that maintains pregnancy by supporting the uterine lining and inhibiting uterine contractions?", "Does the image show features such as chorionic villi that regulate blood flow between maternal and fetal circulations?", "Can you see a structure that acts as a partial barrier to toxins, pathogens, or certain drugs to protect the fetus?", "Is there an object involved in endocrine communication by releasing hormones into both maternal and fetal bloodstreams?", "Does the image contain a structure that mediates the exchange of electrolytes and water to maintain fetal fluid balance?", "Can you identify an object that helps prevent maternal immune rejection of the fetus by modulating immune responses or masking fetal antigens?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify regions that could correspond to both a small and a large tubular organ within the abdomen?", "Does the image show a structure that is part of the digestive system?", "Is there a structure that appears directly connected to the stomach or the cecum?"], "contexual_behavior": [], "functions": ["Is there a visible feature suggesting the presence of beneficial microbes or maintenance of gut flora balance?", "Does the image contain a structure responsible for enzymatic breakdown of macromolecules?", "Can you see an area where water is reclaimed to maintain fluid balance, such as the colon?"]}}}
[ { "answer": "source of granulomatous colitis", "extracted_concepts": [ "granulomatous colitis" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "granulomatous colitis" ], "question": "does this image show source of granulomatous colitis?" }, { "answer": "no", "extracted_concepts": [ "granulomatous colitis", "hemorrhage associated with placental abruption" ], "question": "does hemorrhage associated with placental abruption show source of granulomatous colitis?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "heel ulcer" ], "question": "is heel ulcer present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "colon" ], "question": "is colon present?" }, { "answer": "no", "extracted_concepts": [], "question": "is there present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" } ]	["hemorrhage associated with placental abruption", "colon", "gastrointestinal", "granulomatous colitis", "gastrointestinal system", "heel ulcer"]	{"hemorrhage associated with placental abruption": {"yes_questions": {"contexual_properties": ["Does the image show evidence of abnormal bleeding in association with the placenta?", "Can you identify signs of blood accumulation near the site where the placenta attaches?", "Is there visual evidence of disrupted placental attachment accompanied by hemorrhage?", "Does the image contain features consistent with bleeding related to placental separation?"], "properties": ["Is there evidence of a fluid accumulation with a volume that could range from 500 to over 2000 milliliters?", "Can you identify an area where the color suggests partially clotted maternal blood, appearing dark red?", "Does the image show a region where blood loss might be occurring at a rate exceeding 100 milliliters per minute?", "Is there a sign of blood loss that could result in a hemoglobin concentration below 10 grams per deciliter?", "Can you see indications that clotting time may be prolonged, possibly exceeding 10 minutes?", "Does the image reveal a collection of fluid containing erythrocytes, plasma, platelets, and coagulation factors?", "Is there a feature suggesting a hematocrit level reduced to less than 30 percent?", "Can you identify a region where the pH might be slightly acidic, between 7.2 and 7.35, possibly due to shock or hypoperfusion?", "Is there a fluid present that appears to be at or near body temperature, around 36 to 37 degrees Celsius?", "Does the image suggest the presence of blood with reduced viscosity compared to normal?"], "relational": ["Does the image show evidence of a disruption at the interface between the placenta and the uterine wall?", "Can you identify blood accumulation near the maternal-fetal interface?", "Is there visual evidence of blood extravasation involving spiral arteries or decidual vessels?", "Does the image reveal abnormalities in the retroplacental area or intervillous space?", "Can you see any changes affecting the fetal membranes, umbilical cord, or fetus that might result from a nearby hemorrhagic event?", "Is there a region where the decidua basalis or myometrium appears altered or disrupted?", "Does the image show anatomical barriers, such as the chorionic plate or amniotic membrane, separating a blood collection from the fetus?", "Are there signs of secondary involvement of pelvic structures such as the cervix, vagina, or pelvic connective tissues?", "Can you identify a site of hemorrhage originating from the maternal tissue at the placental attachment?", "Is there visual evidence of the placenta being partially or completely detached from the uterine wall?"], "contexual_behavior": ["Does the image show evidence of abnormal blood accumulation near the placenta?", "Can you identify signs of bleeding in association with placental tissue?", "Is there a visible area suggesting disrupted attachment between the placenta and the uterine wall accompanied by hemorrhage?", "Does the image display features consistent with blood loss adjacent to the placenta?"], "functions": ["Does the image show evidence of significant blood loss that could result in maternal hypovolemia or impaired oxygen delivery to the fetus?", "Is there visual indication of decreased maternal blood volume, such as signs that might suggest hypotension or compensatory tachycardia?", "Can you identify disruption of placental integrity that might reduce oxygen and nutrient transfer to the fetus?", "Does the image suggest placental dysfunction that could lead to fetal oxygen deprivation or nutrient deficiency?", "Is there evidence of compromised placental perfusion that could cause fetal distress or hypoxemia?", "Can you see any features that might indicate activation of coagulation pathways, such as areas suggesting coagulopathy or disseminated intravascular coagulation?", "Does the image show increased uterine contractility or tone that could worsen placental separation?", "Are there visual cues suggesting maternal compensatory mechanisms, such as vasoconstriction or increased heart rate, to maintain perfusion?", "Can you identify reduced fetal blood flow that might result in fetal anemia or compromised fetal circulation?", "Is there evidence of physiological responses such as sympathetic activation or blood redistribution in response to acute blood loss?", "Does the image show signs consistent with hypovolemic shock, such as rapid depletion of maternal blood volume or impaired tissue perfusion?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you observe a nuclear inclusion that may contain viral proteins, cellular proteins, or nucleic acids such as DNA or RNA?", "Can you identify an object inside the nucleus that appears eosinophilic or basophilic depending on the stain used?", "Does the frequency of these nuclear structures vary among cells, possibly depending on the underlying disease process?"], "relational": ["Do you observe inclusions in the nuclei of neurons, hepatocytes, or epithelial cells?", "Are there nuclear features visible in tissues such as brain, liver, or epithelial tissue?", "Can you identify structures located inside the nuclear matrix?"], "contexual_behavior": [], "functions": ["Can you see a nuclear feature that could be involved in protein quality control by sequestering aberrant or misfolded proteins?", "Does the image contain a nuclear component that could modulate the availability and function of nuclear proteins through sequestration?", "Can you identify a nuclear feature that may contribute to the pathogenesis of neurodegenerative disorders or viral infections by disrupting normal nuclear functions?"]}}, "colon": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify regions such as the ascending, transverse, descending, or sigmoid segments within the image?", "Is there a structure that appears adjacent to the small intestine or rectum?", "Can you see any anatomical features located near the kidneys or bladder?", "Does the image contain vessels that could correspond to the superior or inferior mesenteric arteries supplying a digestive organ?", "Is there evidence of innervation by the enteric nervous system or by fibers from the vagus or pelvic splanchnic nerves in any visible structure?", "Can you identify a region that is continuous with the rectum at its terminal end?", "Is there a visible junction where the ileum meets a larger tubular structure, possibly involving the ileocecal valve?", "Does the image show a wall composed of multiple layers such as mucosa, submucosa, muscularis propria, and serosa?", "Are there lymphatic structures present, such as mesenteric or colic lymph nodes, associated with a tubular digestive organ?", "Can you identify anatomical boundaries such as the ileocecal junction or rectosigmoid junction in the image?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for absorbing water from digested food?", "Can you identify an area involved in regulating electrolyte levels, such as sodium and chloride absorption?", "Is there a region where undigested carbohydrates might be fermented by anaerobic bacteria?", "Does the image contain a structure that compacts waste material and stores it until elimination?", "Can you see evidence of an environment that supports the proliferation of beneficial gut microbiota?", "Is there a visible area where vitamins like vitamin K and B vitamins could be absorbed after being synthesized by resident bacteria?", "Does the image show a structure that propels fecal matter toward the rectum for excretion?", "Can you identify a region involved in maintaining fluid balance through water and electrolyte reabsorption?", "Is there a structure present that contributes to immune defense via gut-associated lymphoid tissue or antimicrobial peptide production?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a visible anatomical barrier, such as a fibrous capsule, basement membrane, or endothelial lining, separating a mass from adjacent healthy tissue?", "Is there a lesion present in a region like the skin, lungs, gastrointestinal tract, brain, or soft tissues?", "Does the image show a mass that contains both connective and vascular tissues?"], "contexual_behavior": ["Is there a structure that might show increased angiogenesis in response to hypoxia, potentially through upregulation of angiogenic factors such as VEGF?", "Does the image show a mass with evidence of increased fibrin deposition, possibly as a result of chronic inflammation and ongoing tissue injury?", "Is there a mass that appears expanded, possibly due to increased vascular permeability during acute inflammation or exposure to pro-inflammatory mediators?"], "functions": ["Does the image show a mass that appears to be involved in both controlling bleeding and initiating a local inflammatory response?", "Is there a mass that could be facilitating the recruitment of immune cells by expressing adhesion molecules or chemotactic factors?", "Is there a structure that appears to be regulating the release of inflammatory mediators through activation of immune cells at the site?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see any structural changes in the heart muscle that might suggest early onset disease in individuals below a typical age threshold?", "Is there evidence of involvement of the cardiac conduction system or subendocardial regions?", "Are there features present that indicate the cardiovascular system is primarily affected?"], "contexual_behavior": [], "functions": ["Is there evidence of reduced patency in the coronary arteries, such as visible narrowing or blockage?", "Can you detect abnormalities in the cardiac conduction system or features that might suggest arrhythmias?", "Does the image show features consistent with early-onset atherosclerosis or arterial stenosis in the coronary vessels?"]}}, "granulomatous colitis": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a disease process affecting the digestive system?", "Is there any abnormality involving the large intestine, particularly the colon?", "Can you identify changes that extend through multiple layers such as the mucosa, submucosa, or muscularis propria of the colon?", "Are there lesions containing immune cell types like macrophages, epithelioid cells, multinucleated giant cells, or lymphocytes?", "Is there visible granulomatous inflammation within the colonic mucosa?", "Are anatomical structures adjacent to the colon, such as pericolonic fat, mesentery, or serosa, affected or altered?", "Can you see involvement of lymphatic structures such as mesenteric lymph nodes or colonic lymphatic vessels near the affected area?", "Is there evidence of vascular supply from branches of the superior or inferior mesenteric arteries to the affected region?", "Are there signs of secondary involvement in the terminal ileum, perianal region, or skin?", "Do the rectum or sigmoid colon appear to be the primary sites of abnormality in the image?"], "contexual_behavior": [], "functions": ["Does the image show evidence of chronic inflammation or granuloma formation within the colon?", "Can you identify areas where immune cells such as macrophages or T cells appear to be persistently activated in colonic tissue?", "Is there visible mucosal damage or signs of increased epithelial permeability in the colon?", "Does the image suggest impaired nutrient absorption due to mucosal injury or architectural distortion of the colon?", "Are there features indicating ongoing or persistent inflammatory processes in the colonic tissue?", "Can you observe recruitment or clustering of immune cells like macrophages, lymphocytes, or neutrophils at sites of colonic inflammation?", "Is there evidence of delayed mucosal healing or impaired epithelial regeneration in the colon?", "Does the image suggest alterations in the local gut environment that could be associated with dysbiosis or microbiota dysregulation?", "Are there visible granulomas formed by aggregates of activated macrophages and other immune cells in the colon?", "Can you detect changes in colonic motility or transit, such as features that might correspond to diarrhea or constipation?", "Is there evidence of increased local production of pro-inflammatory cytokines, such as TNF-alpha, IL-1, or IL-6, in the colonic tissue?", "Does the image reveal signs of tissue remodeling, fibrosis, or structural changes in the wall of the colon?"]}, "no_questions": {"contexual_properties": ["Does the tissue display irregular glandular arrangements typical of dysplasia or malignancy?", "Does the image contain features consistent with reactive epithelial changes due to inflammation?", "Do you see signs of high mitotic activity in regions that may represent rapidly proliferating or malignant lesions?"], "properties": ["Can you identify a region where the number of glands per unit area appears significantly increased, possibly exceeding 10 per low-power field?", "Is there a region where the nuclear-to-cytoplasmic ratio appears elevated, with nuclei that seem enlarged relative to the cytoplasm?", "Does the image show an area where glands are closely packed together with little intervening stroma?"], "relational": ["Does the image display glandular proliferation within an organ parenchyma or epithelial compartment?", "Can you identify areas with increased density of glands within an epithelial layer?", "Does the image show regions where glands are closely packed with little separation by stromal tissue?"], "contexual_behavior": ["Can you observe features in endocrine tissue where excessive proliferation may be affecting hormone production?", "Is there a region where overcrowding of glandular cells could be limiting nutrient or oxygen delivery, potentially reducing gland function?", "Can you see signs of tissue repair or restored glandular spacing that might indicate resolution of prior injury?"], "functions": ["Can you observe alterations in tissue architecture, like irregular gland shapes or loss of normal spacing?", "Does the image suggest compromised nutrient or oxygen delivery, such as reduced vascular supply to densely packed glandular regions?", "Is there evidence of impaired secretion, such as glands with obstructed or narrowed lumens?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": ["Is there a mass that appears heterogeneous, with regions of necrosis, fibrosis, and viable tissue?", "Can you see a mass with cystic regions, possibly resulting from central necrosis or degeneration?", "Can you identify a lesion that has decreased in size, possibly indicating a response to therapy?"], "properties": ["Does the tumor appear to be larger than 2 centimeters in size?", "Are there features suggestive of underlying TP53 or BRCA1 gene mutations in the tumor?", "Can you identify a tumor with high histological grade features?"], "relational": ["Is there a tumor present that lacks visible expression of estrogen receptor, progesterone receptor, and HER2?", "Does the image include tissue from the breast, lymph nodes, or lung that could be examined for metastatic disease?", "Is there evidence of a malignancy involving the axillary lymph nodes?"], "contexual_behavior": [], "functions": ["Does the tumor microenvironment show signs of stromal cell recruitment or increased inflammation?", "Does the image suggest early recurrence or resistance to targeted therapies in any of the cancerous regions?", "Does the image show a tumor with features suggestive of high proliferation or rapid cell division?"]}}, "heel ulcer": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of tissue disruption in the posterior region of the foot?", "Does the image show an area where the skin, subcutaneous tissue, or underlying muscle appears damaged?", "Can you identify a lesion affecting both the epidermis and dermis layers?", "Is there visible involvement of the subcutaneous tissue in the region near the calcaneus?", "Does the image display soft tissue loss or inflammation adjacent to the Achilles tendon or plantar fascia?", "Can you see any signs of compromised tissue integrity that might increase infection risk?", "Is there a structure in the image that could impact both the integumentary and musculoskeletal systems?", "Does the image show disruption of connective tissues such as fascia, ligaments, or adipose tissue beneath the skin?", "Can you identify an area where blood supply from the posterior tibial artery or its branches might be affected?", "Is there a region where nerves like the medial or lateral plantar nerves, or the sural nerve, could be at risk due to tissue damage?"], "contexual_behavior": ["Is there a wound on the foot that appears to have delayed healing, possibly due to poor blood circulation or limited oxygen delivery?", "Can you identify a lesion that might be more susceptible to infection in individuals with diabetes mellitus?", "Does the image show a wound that has failed to close, potentially as a result of prolonged pressure or impaired blood flow?", "Is there evidence of increased exudate or fluid accumulation in a foot wound, which could indicate bacterial colonization and inflammation?", "Can you see a wound that may exhibit impaired tissue regeneration, possibly in the context of malnutrition or nutrient deficiency?", "Is there a lesion with reduced healing that could be associated with peripheral arterial disease or arterial insufficiency?", "Does the image show a wound that appears less responsive to standard care, suggesting an immunocompromised state or impaired healing?", "Can you identify a foot wound with signs of deep tissue involvement or necrosis, possibly resulting from sustained mechanical stress?", "Is there visible increased inflammation in a lesion, which could be due to acute infection and immune activation?", "Does the wound lack granulation tissue, potentially as a result of chronic ischemia or impaired angiogenesis?", "Is there evidence that the wound is healing more rapidly, possibly following pressure relief interventions or improved perfusion?", "Can you see a lesion that demonstrates impaired healing in the context of neuropathy or sensory loss?", "Is there a wound that appears to be increasing in size, which might be due to inadequate offloading or continued pressure?", "Does the image show a lesion with decreased oxygenation, potentially in a patient with heart failure or hypoperfusion?", "Is there a wound that appears more difficult to heal in the presence of edema or excess interstitial fluid?"], "functions": ["Is there evidence of an open wound on the heel that could compromise the skin barrier?", "Does the image show tissue loss or damage in the heel region that might impair mobility or weight-bearing?", "Can you identify signs of local inflammation, such as redness or swelling, around a wound on the heel?", "Is there visual indication of prolonged inflammation or delayed healing in a wound located on the heel?", "Does the image reveal features suggesting impaired tissue regeneration or poor formation of new tissue in the heel area?", "Are there signs of persistent tissue damage or recruitment of inflammatory cells in a lesion on the heel?", "Can you observe any disruption to normal cell proliferation, angiogenesis, or extracellular matrix remodeling in the affected heel tissue?", "Is there visual evidence of reduced blood circulation, such as pallor or edema, near a wound on the heel?", "Does the image show an area on the heel that appears at increased risk of infection due to exposed underlying tissues?", "Can you identify features consistent with chronic pain or nerve exposure in the region of a heel wound?"]}, "no_questions": {"contexual_properties": ["Is there evidence of increased swelling or edema in the region of acute injury?", "Does the imaging reveal abnormal radiographic features, such as multiple fracture lines or callus, at initial presentation or during healing?", "Are there changes in limb length, such as shortening, due to overriding bone fragments or bone loss?"], "properties": ["Can you identify bone fragments that are each between 2 and 10 centimeters in length?", "Is there visible angulation at the fracture sites between 10 and 30 degrees?", "Does the image suggest a healing process that might require 8 to 16 weeks depending on the extent and location of the injuries?"], "relational": ["Is there visual indication of injuries involving both the appendicular and axial skeleton?", "Are there signs of injury in flat bones or the pelvis?", "Does the image show evidence of a pathological condition affecting the skeletal system in more than one location?"], "contexual_behavior": [], "functions": ["Is there visual indication of restricted mobility or the use of immobilization devices, such as casts or splints, on more than one limb?", "Can you identify signs that tissue repair or regeneration may be impaired, such as persistent wounds or delayed closure at multiple sites?", "Does the image suggest disturbances in calcium or phosphate regulation, such as abnormal bone density or signs of bone resorption?"]}}}
[ { "answer": "the uterus", "extracted_concepts": [ "uterus", "submucosal", "myometrial", "tumors", "subserosal", "whorled appearance", "cut section" ], "question": "what is opened to show multiple submucosal, myometrial, and subserosal gray-white tumors, each with a characteristic whorled appearance on cut section?" } ]	["uterus", "submucosal", "myometrial", "tumors", "subserosal", "whorled appearance", "cut section"]	{"uterus": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify a region that could correspond to the fundus, body, isthmus, or cervix?", "Is there an organ located adjacent to the bladder or rectum?", "Does the image contain a structure positioned near the ovaries?", "Can you see blood vessels that might be the primary supply to a reproductive organ, such as the uterine artery or vein?", "Is there evidence of supporting ligaments like the broad ligament, round ligament, or uterosacral ligament?", "Does the image show a connection between the ovaries and another structure via tubular pathways?", "Can you identify features related to the menstrual or reproductive cycles?", "Is there a visible anatomical connection between a structure and the vagina?", "Can you see tissue layers that could correspond to the endometrium, myometrium, or perimetrium?", "Does the image show tubular structures connecting to a larger organ at the uterine cornua?", "Is there an organ located within the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a structure that supports embryo implantation or fetal development?", "Is there an organ present that undergoes cyclical changes in its lining in response to hormones?", "Can you identify a tissue that sheds periodically as part of menstruation?", "Does the image contain a structure that provides a protective environment for fetal growth?", "Is there evidence of an organ that expands during pregnancy to accommodate a growing fetus?", "Can you see a structure that supports placental attachment and maternal-fetal exchange?", "Is there an object that generates coordinated muscular contractions to facilitate childbirth?", "Does the image show a tissue that responds to hormones such as estrogen or progesterone?", "Is there a structure that produces secretory factors to facilitate embryo implantation?", "Can you identify an organ that forms a physical barrier and provides immunological protection for a developing fetus?", "Does the image contain a structure responsible for expelling menstrual blood and tissue?", "Is there evidence of rhythmic contractions under the influence of oxytocin to aid in delivery?", "Can you see a tissue that supplies nutrients and removes waste for fetal development?", "Is there an organ whose structural and functional changes are regulated by reproductive hormones?", "Does the image show a structure essential for fertility, pregnancy support, or menstrual health?"]}, "no_questions": {"contexual_properties": ["Does the image contain features consistent with the floor of the cranial vault after removal of its contents?", "Can you identify an area that exposes the internal surface of the skull?", "Is there a visible region where the base of the cranial cavity is open and the brain tissue is not present?"], "properties": ["Does the image show a cranial structure where the brain is absent?", "Can you identify bony features at the base of the skull that are exposed due to the removal of neural tissue?", "Is there evidence of an anatomical region that would normally support or house the brain but is now empty?"], "relational": ["Can you identify bony structures such as the occipital, sphenoid, temporal, ethmoid, or frontal bones?", "Are features of the skull floor, such as bony landmarks or foramina, present in the image?", "Does the image display passageways for cranial nerves such as the olfactory or hypoglossal nerves?"], "contexual_behavior": ["Does the image show a region where cerebrospinal fluid drainage might be impaired due to disruption of anatomical barriers such as the dura mater or arachnoid granulations?", "Is there visual evidence of altered passage of air or fluids between cranial and extracranial spaces, suggesting compromised natural barriers?", "Is there evidence of breached bony or meningeal layers that could compromise the barrier function against pathogen entry?"], "functions": ["Are there visible landmarks such as foramina, fissures, or bony ridges important for orientation during neurosurgical interventions?", "Can you see anatomical features that would assist in planning complex procedures involving the base of the skull?", "Does the image provide access to bony and soft tissue features that can be correlated with neurological functions?"]}}, "submucosal": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a layer in the image that appears pale or whitish in color due to its connective tissue content?", "Can you identify a region that is soft, pliable, and slightly elastic in texture?", "Does the image show a tissue layer with a high density of blood vessels to support mucosal function?", "Is there a structure that contains a substantial number of nerve fibers, possibly indicating the presence of a submucosal plexus?", "Can you see a layer that includes loose connective tissue, blood vessels, nerves, and occasional glands?", "Is there a region that might contain fibroblasts, immune cells, endothelial cells, or smooth muscle cells?", "Does the image show a tissue layer whose thickness is between 200 micrometers and 1 millimeter?", "Is there a part of the tissue that could have a water content of around 60\u201370% by weight?", "Can you identify a region that might have a collagen content of approximately 20\u201330% of its dry weight?", "Is there a layer that could contain elastin making up about 2\u20135% of its dry weight?", "Does the image include a tissue region whose density is close to 1.04 grams per cubic centimeter?", "Is there a layer that likely maintains a physiological pH around 7.35\u20137.45?", "Can you see a region that might have glycosaminoglycans comprising about 1\u20133% of its dry weight?", "Is there a tissue layer that represents only a small fraction of the total wall volume, depending on the organ?", "Does the image show a region that would be expected to have a temperature close to 37 degrees Celsius?"], "relational": ["Does the image show a layer that is part of the wall of a tubular organ such as the esophagus or intestine?", "Can you identify a structure that is located between the mucosa and the muscularis externa?", "Is there a region in the image that lies just beneath the mucosa and provides support or vascular supply to it?", "Does the image contain a layer that separates the mucosa from the muscularis externa?", "Can you see blood vessels such as arterioles, venules, or capillaries supplying the mucosa within a supporting layer?", "Is there evidence of nerves, such as the submucosal (Meissner's) plexus, within a connective tissue layer?", "Does the image show loose connective tissue with collagen and elastic fibers situated between the mucosa and muscularis externa?", "Can you identify a layer containing lymphatics, nerves, and blood vessels within the wall of the stomach or intestine?", "Is there a supporting structure within the wall of the large intestine that contains both vascular and neural elements?", "Does the image display a region in the wall of a tubular gastrointestinal organ that is rich in connective tissue and lies internal to the muscularis externa?"], "contexual_behavior": [], "functions": ["Does the image show a layer that provides structural support between the mucosa and muscularis?", "Can you identify a region that houses both blood vessels and nerves?", "Is there evidence of a network supplying nutrients and oxygen to the mucosa?", "Does the image contain a layer with extensive vascular and lymphatic vessels for nutrient transport?", "Can you see features suggesting the regulation of blood flow to the mucosa?", "Is there a visible structure that could contain a neural plexus involved in vasoregulation?", "Does the image show glands whose activity might be controlled by neural input?", "Can you identify a layer that may contain secretory glands within the gastrointestinal tract?", "Is there a region that could modulate gut motility by influencing smooth muscle contraction?", "Does the image suggest the presence of a neural network coordinating local reflexes in the gut?", "Can you see evidence of immune cells or lymphoid tissue involved in immune surveillance?", "Is there a layer that might participate in immune defense against pathogens?", "Does the image show a region that could transmit neural signals to secretory cells for glandular activity?", "Is there evidence of tissue responding to injury or inflammation, such as increased vascular permeability or immune cell recruitment?", "Can you identify a flexible connective tissue base supporting the overlying mucosa?", "Does the image suggest integration of neural, vascular, and immune signals to maintain local tissue homeostasis?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a component of the female reproductive system that is located within the pelvic region?", "Does the image show a pathway involved in gamete transport or fertilization?", "Is there a visible feature that maintains close anatomical relationships with peritoneal or connective tissues?"], "contexual_behavior": ["Does the image reveal a tubular feature with increased adherence that might be linked to chemical exposure or signs of fibrosis?", "Is there a tubular structure that shows changes in adherence, possibly as a result of immune-mediated damage or autoimmune disease?", "Does the image show a tubular structure that appears detached or less adherent, possibly due to severe inflammation or tissue necrosis?"], "functions": ["Is there a conduit present that could guide the movement of fluids or cells and modulate flow dynamics?", "Can you see an object that might regulate the rate of flow or selectively permit the passage of certain substances?", "Does the image contain a structure that supports organ function by ensuring efficient delivery or removal of substances?"]}}, "myometrial": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is a component of the uterus?", "Can you identify a layer primarily composed of smooth muscle tissue within the female reproductive system?", "Is there a region that lies between the endometrium and the perimetrium?", "Does the image display a layer containing embedded blood vessels, nerves, and connective tissue fibers?", "Can you see evidence of blood supply from uterine arteries or their branches within a uterine layer?", "Is there a structure that provides contractile support to the endometrium?", "Does the image show a layer situated internal to the perimetrium?", "Can you identify a uterine layer located within the pelvic cavity?", "Is there a region innervated by autonomic nerves, such as those from the uterovaginal plexus?", "Does the image contain a structure that is part of the female reproductive system and composed of smooth muscle?"], "contexual_behavior": ["Does the image show a structure whose contractile activity increases significantly during the onset and progression of labor?", "Is there evidence of impaired relaxation in a tissue that could be associated with preterm labor?", "Can you identify a region that might display increased responsiveness to oxytocin as pregnancy approaches term?", "Does the image contain a tissue where contractility may be decreased due to the influence of progesterone during pregnancy maintenance?", "Is there a structure that could exhibit abnormal function or altered smooth muscle architecture in the presence of uterine fibroids?", "Can you see a tissue where tone might be elevated during menstruation as a result of increased prostaglandin levels?", "Is there evidence of diminished contractile response in a tissue that could be associated with aging or post-menopausal changes?", "Does the image show a region where activity might be altered during postpartum recovery as the uterus involutes?", "Can you identify a tissue that could display excessive contractility, potentially leading to painful uterine cramps as seen in dysmenorrhea?", "Is there a structure whose function might be compromised in the presence of infection or inflammation, resulting in abnormal contractility?", "Does the image include a tissue that could show increased responsiveness to prostaglandins before the onset of labor, facilitating cervical ripening and contractions?", "Is there evidence of failed relaxation and sustained contractions that might be seen during uterine hyperstimulation?", "Can you identify a region where contractile patterns may change in response to hypoxia, resulting in decreased contractility and altered contraction frequency?", "Does the image show a tissue where activity might be decreased after menopause due to hormonal decline?", "Is there a structure whose function could be altered by hormonal contraceptives, resulting in reduced contractility and changes in menstrual patterns?"], "functions": ["Does the image show a structure that provides contractility and structural support to the uterus?", "Is there a layer visible that generates coordinated muscle contractions for uterine peristalsis or expulsion?", "Can you identify a region responsible for strong, rhythmic contractions during labor and childbirth?", "Does the image contain tissue that aids in expelling menstrual blood by contracting to shed the endometrial lining?", "Is there a part of the uterus that accommodates growth and maintains tone to support pregnancy and protect the fetus?", "Can you see a region that responds to hormonal signals such as oxytocin or prostaglandins by changing its contractile activity?", "Is there evidence of a structure that contracts after delivery to compress blood vessels and help prevent postpartum hemorrhage?", "Does the image show a layer involved in uterine involution and postpartum recovery by facilitating tissue remodeling?", "Can you identify a part of the uterus that assists in sperm transport by generating contractions toward the fallopian tubes?", "Is there a thick, muscular middle layer visible that contributes to the uterus's structural integrity and resists mechanical stress?"]}, "no_questions": {"contexual_properties": ["Is there a mucosal defect that appears edematous, indicating acute inflammation or tissue injury?", "Is there evidence of increased bleeding at a mucosal site, possibly associated with mucosal disruption or coagulopathy?", "Can you see a tear with irregular edges, which could suggest impaired healing or secondary infection?"], "properties": ["Is there a linear lesion following the long axis of the gastroesophageal junction or esophagus visible in the image?", "Does the image show a mucosal disruption measuring between 0.5 and 4 centimeters in length and 2 to 10 millimeters in width?", "Is there a structure with irregular, friable texture and partial mucosal disruption without evidence of full-thickness perforation?"], "relational": ["Is there evidence of tissue disruption without full-thickness perforation near the lower esophageal sphincter or gastric cardia?", "Does the image reveal a tear that is part of the gastrointestinal system and closely related to the circulatory system?", "Can you identify a lesion located in the distal esophagus or proximal stomach?"], "contexual_behavior": ["Does the image show a mucosal break near the gastroesophageal junction that might weaken the anti-reflux barrier?", "Does the image reveal exposed submucosa that could increase susceptibility to infection?", "Can you identify a lesion where ongoing mechanical trauma or possible coagulopathy could disrupt normal clot formation and stable hemostasis?"], "functions": ["Is there evidence of mucosal irritation that might trigger protective reflexes such as vomiting or coughing?", "Can you identify a break in the esophageal mucosa with exposure of submucosal vessels, suggesting a risk of hemorrhage?", "Does the image show a disruption of the mucosal barrier at the gastroesophageal junction that could increase the risk of bleeding?"]}}, "tumors": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to be increasing in size, suggesting active cell division or growth?", "Can you identify an area that seems to have decreased in size, possibly indicating a response to therapy or immune activity?", "Does the image show a region with altered coloration that could be due to changes in blood supply, necrosis, or hemorrhage?", "Is there evidence of increased vascularization in any structure, which might suggest angiogenesis stimulated by growth factors?", "Can you see a region that appears necrotic, possibly due to insufficient blood supply or rapid expansion?", "Is there a visible area with calcifications, which could result from chronic necrosis or degeneration?", "Does the image show a structure with cystic features, such as central degeneration or fluid accumulation?", "Can you identify a region with variable density, possibly reflecting differences in cellularity, fibrosis, necrosis, or calcification?", "Is there an area that appears firmer or denser, which might be due to increased fibrosis or a desmoplastic reaction?", "Do you see a region that looks softened, perhaps as a result of necrosis, liquefaction, or cyst formation?", "Is there evidence of increased cellularity in any structure, which could indicate rapid proliferation or a high-grade lesion?", "Does any area display irregular borders, suggesting invasion into surrounding tissues or loss of encapsulation?", "Can you identify a region with mixed composition, such as areas of necrosis, hemorrhage, fibrosis, or cystic change?", "Is there a structure that appears hypermetabolic, possibly due to rapid growth or malignant transformation?", "Do you see a surface defect or ulceration, which might result from outgrowing the blood supply or invasion of overlying tissue?", "Is there evidence of hemorrhage within a structure, possibly due to fragile new blood vessels or vascular invasion?", "Can you observe any changes that might correspond to fluctuations in marker levels, such as progression, recurrence, or response to treatment?", "Does any region appear more heterogeneous, potentially due to genetic mutations, necrosis, or hemorrhage?", "Is there a structure that seems to have lost its capsule and is infiltrating adjacent tissues, indicating invasive behavior?", "Do you see signs of edema, such as swelling or fluid accumulation, which could result from disrupted vasculature or inflammation?"], "properties": ["Is there a mass in the image whose size appears variable, ranging from a few millimeters to several centimeters?", "Can you identify a structure that could weigh anywhere from less than a gram to several kilograms, depending on its characteristics?", "Does the image show a mass with an irregular, nodular, or spherical shape?", "Is there an area that appears pale, gray, white, red, or yellow in color, possibly reflecting differences in vascularity or necrosis?", "Can you see a structure that looks firm, hard, soft, or gelatinous in consistency?", "Is there a mass that might be composed of neoplastic, stromal, inflammatory, or endothelial cells?", "Does the image suggest a region where cell division is elevated compared to surrounding tissue?", "Is there evidence of a structure that could be growing more rapidly than the adjacent normal tissue?", "Can you identify an area with increased or heterogeneous vascularity, possibly due to angiogenesis?", "Does the image show a region that might contain significant necrotic content, especially in rapidly growing or poorly vascularized areas?", "Is there a mass with density higher than that of the surrounding tissue, or with variable density depending on its composition?", "Can you see a structure that might have a high water content, similar to or slightly less than normal tissue?", "Is there an area that could be associated with altered protein expression, such as overexpression or loss of markers like Ki-67, p53, or HER2?", "Does the image suggest the presence of cells with abnormal DNA content, such as aneuploidy or increased DNA replication?", "Is there a region that could have a lower pH, possibly between 6.5 and 7.0, due to increased glycolysis?", "Can you identify an area that might be hypoxic, with reduced oxygen concentration compared to normal tissue?", "Does the image show a region where glucose uptake or concentration might be elevated?", "Is there a mass that could have increased lipid content, particularly if it resembles tissue types like liposarcoma?", "Can you see evidence of high cellular atypia, such as pleomorphism or abnormal cell morphology?", "Is there a region where the nuclear-to-cytoplasmic ratio appears increased, indicating larger nuclei relative to cytoplasm?"], "relational": ["Does the image show an abnormal mass originating from epithelial, connective, muscle, or nervous tissue?", "Can you identify a lesion present within the lung, liver, breast, colon, or brain?", "Is there a structure that could impact the nervous, respiratory, digestive, or endocrine system?", "Does the image display a mass adjacent to blood vessels, nerves, lymph nodes, or other organs?", "Can you see a region containing neoplastic, stromal, immune, or endothelial cells?", "Is there evidence of arterioles, capillaries, venules, or newly formed blood vessels supplying a mass?", "Does the image show lymphatic vessels, regional lymph nodes, or lymphatic capillaries interacting with a suspicious structure?", "Is there an abnormality located in the head and neck, thorax, abdomen, pelvis, or extremities?", "Can you observe a mass interacting with surrounding connective tissue, possibly through invasion or tissue remodeling?", "Is there a structure that appears to cross anatomical barriers such as the basement membrane, blood-brain barrier, serosal membranes, or fascia?"], "contexual_behavior": ["Is there a structure in the image that appears to have increased blood vessel formation, possibly indicating enhanced angiogenesis?", "Can you identify an area that might be resisting immune cell infiltration or showing signs of immune evasion?", "Does the image show a region where cells could be adapting to low oxygen by increasing glycolytic activity?", "Is there evidence of a mass that might be less responsive to chemotherapy, suggesting drug resistance?", "Can you see a structure that appears to be invading surrounding tissues, possibly in response to inflammation?", "Is there a mass that seems to be disrupting the normal architecture of nearby tissue, potentially suppressing local function?", "Does the image show a region where growth rate appears reduced, possibly due to nutrient deprivation or metabolic adaptation?", "Can you identify an area where cells might be avoiding programmed cell death, suggesting evasion of apoptosis?", "Is there a mass that appears to have decreased proliferation, possibly following radiation therapy?", "Does the image show a region that could be secreting immunosuppressive factors, as indicated by reduced immune cell presence nearby?", "Is there evidence of altered cell adhesion or motility in response to hormonal influence, possibly affecting metastatic potential?", "Can you see a mass that is compressing or infiltrating adjacent organs, potentially causing dysfunction due to mass effect?", "Is there a region where increased glycolysis might be occurring in response to low oxygen levels?", "Does the image show an area where antigen presentation to immune cells may be reduced, possibly due to downregulation of MHC molecules?", "Can you identify a structure that might be adapting its behavior in response to targeted therapy, such as by activating alternative signaling pathways?", "Is there evidence of increased production of growth factors to support proliferation and new blood vessel formation?", "Does the image show a mass with reduced growth, possibly following anti-angiogenic treatment and decreased vascular supply?", "Can you see a region that appears to be recruiting stromal cells, as indicated by increased presence of supporting cell types?", "Is there evidence of impaired cell cycle regulation, possibly due to genetic mutations affecting regulatory genes?", "Does the image show a structure that might be resisting oxidative stress, as suggested by features indicating upregulated antioxidant defenses?"], "functions": ["Does the image show a region where cell growth appears uncontrolled or excessive compared to surrounding tissue?", "Can you identify an area that seems to invade or disrupt the normal architecture of adjacent structures?", "Is there evidence of a mass compressing nearby anatomical features or altering organ performance?", "Does the image reveal a structure that could be dysregulating the cell cycle or promoting genetic instability?", "Can you see a region where abnormal cell proliferation might be driven by sustained mitogenic signaling?", "Is there a visible area that could be evading immune detection, such as by lacking typical antigen presentation markers?", "Does the image show evidence of new blood vessel formation, possibly due to secretion of vascular endothelial growth factors?", "Can you identify a structure that appears to degrade the extracellular matrix or invade surrounding tissues?", "Is there a region that might be entering blood or lymphatic vessels, suggesting potential for metastasis?", "Does the image display features consistent with increased glycolysis or altered metabolic activity in a localized area?", "Can you see a structure that seems resistant to programmed cell death, such as by persisting despite cellular stress or damage?", "Is there evidence of recruitment or activation of stromal cells in the vicinity of an abnormal mass?", "Does the image show signs of chronic inflammation, such as accumulation of inflammatory cells near a suspicious area?", "Can you identify a region that might be producing ectopic hormones or disrupting normal endocrine feedback?", "Is there a visible interaction between an abnormal structure and immune or stromal cells, such as recruitment of fibroblasts or macrophages?", "Does the image reveal obstruction of ducts or vessels, tissue necrosis, or impairment of physiological processes in association with a mass?"]}, "no_questions": {"contexual_properties": ["Is there evidence of increased fluid accumulation at a site of acute inflammation or infection?", "Does the fluid appear protein-rich, which could result from increased endothelial permeability due to inflammation?", "Is there a region where the fluid appears purulent, possibly due to neutrophil accumulation and bacterial infection?"], "properties": ["Does the image show a fluid that is likely close to body temperature, around 37\u00b0C?", "Is there a substance that might have a chloride concentration similar to or slightly lower than plasma?", "Does the image show a fluid that might have a high viscosity compared to other body fluids?"], "relational": ["Can you identify organs like the lungs, heart, liver, joints, or skin that appear affected by localized fluid or cellular accumulation?", "Does the image display changes in serous, synovial, or mucous membranes that could indicate fluid buildup?", "Is there evidence of abnormal fluid accumulation in the lungs, joints, peritoneum, pleura, or skin?"], "contexual_behavior": ["Is there visible swelling or edema that could be attributed to increased hydrostatic pressure, as seen in congestive heart failure?", "Can you see signs of purulent material, such as a collection of neutrophils and cellular debris, that could indicate bacterial invasion?", "Can you identify a shift from clear to blood-tinged fluid, which might suggest vascular damage and red blood cell leakage?"], "functions": ["Does the image reveal a moist environment that could facilitate wound healing or support cell migration?", "Is there a feature that might be delivering nutrients such as proteins, glucose, or electrolytes to damaged tissues?", "Can you see a fluid that might be flushing microorganisms out of tissue or supporting phagocytosis?"]}}, "subserosal": {"yes_questions": {"contexual_properties": ["Is there a mass in the image that appears larger, possibly due to hormonal stimulation or pregnancy?", "Can you identify a lesion that shows calcification, which might result from chronic degeneration or aging?", "Does the image show a tumor with an irregular shape, potentially caused by mechanical pressure, torsion, or varying growth rates?", "Is there a growth that appears cystic, suggesting cystic degeneration due to inadequate blood supply?", "Can you see a nodule that is attached to the serosal surface by a stalk, indicating pedunculation?", "Does the image reveal a structure with altered texture, possibly due to degeneration, fibrosis, or edema?", "Is there evidence of necrosis within a mass, which could be due to compromised blood supply such as torsion or infarction?", "Can you observe a lesion with color changes that might be explained by hemorrhage, necrosis, or vascular alterations?", "Is there a fibroid that appears edematous, possibly due to fluid accumulation from venous congestion or degeneration?", "Does the image show a tumor with areas of hemorrhage, which could result from vascular rupture or infarction?", "Is there a mass that appears to have decreased in size, perhaps following menopause or medical therapy that reduces hormonal stimulation?", "Can you identify a lesion with increased vascularity, suggesting rapid growth or angiogenesis?", "Does the image display a growth with a multilobulated appearance, possibly due to irregular expansion or coalescence of nodules?", "Is there evidence of degeneration in a mass, which might be related to aging, ischemia, or therapeutic intervention?", "Can you see a tumor that shows changes in composition, such as hyaline, cystic, or myxoid degeneration?"], "properties": ["Is there a layer visible in the image that appears pale yellow or whitish in color?", "Can you identify a soft and pliable tissue beneath a serous membrane?", "Does the image show a structure with moderate fat content, possibly indicated by the presence of adipocytes?", "Is there a region that appears moderately vascularized, containing small blood vessels or capillaries?", "Can you see tissue that is approximately 0.5 to 2 millimeters thick?", "Is there an area composed of loose connective tissue and adipose tissue?", "Does the image reveal a layer that might contain fibroblasts, endothelial cells, or immune cells?", "Can you identify a tissue with moderate amounts of type I and type III collagen fibers?", "Is there a region with low to moderate elastic fiber content, suggesting limited elasticity?", "Does the image show a tissue whose density could be estimated around 1.02 to 1.06 g/cm\u00b3?", "Is there a layer likely to have a water content of about 60\u201370% by weight?", "Can you see a structure that would be expected to have a physiological pH close to 7.4?", "Is there a tissue layer whose temperature would match core body temperature, approximately 37\u00b0C?"], "relational": ["Does the image show a region located just beneath the serosal membrane of an organ?", "Can you identify a tissue layer that is adjacent to the serosa on the outside and the muscular layer on the inside?", "Is there a structure present that could be found in organs such as the uterus, intestines, or stomach?", "Does the image display a transitional zone immediately beneath the serosa and above deeper tissue layers?", "Can you see a region that might belong to the gastrointestinal, reproductive, or urinary systems and is situated between the serosa and muscularis?", "Is there evidence of cells such as fibroblasts, adipocytes, or macrophages within a layer beneath the serosa?", "Does the image include anatomical compartments like the peritoneal cavity or muscularis layer near a thin tissue region?", "Can you identify structures such as blood vessels, nerves, or lymphatics interacting with a layer just below the serosa?", "Is there a tissue layer positioned between the serosa and the muscularis within the wall of an organ?", "Does the image show loose connective tissue or adipose tissue situated beneath the serosal surface?"], "contexual_behavior": ["Is there evidence of a tissue layer with disrupted extracellular matrix or cellular integrity that could indicate barrier dysfunction due to inflammation?", "Can you identify a region where connective tissue appears weakened, possibly suggesting impaired support to underlying organs as seen in chronic edema or fibrosis?", "Does the image show increased permeability or infiltration by leukocytes, which might suggest a response to infection in a tissue barrier?", "Is there a visible alteration in connective tissue organization that could be attributed to surgical trauma or manipulation?", "Can you observe excessive collagen deposition or fibroblast proliferation that would indicate fibrosis in a chronic inflammatory setting?", "Does the image reveal a tissue layer that appears stretched or thinned, potentially reducing its cushioning function during rapid organ enlargement?", "Is there a region with reduced vascularity or signs of hypoperfusion, which could suggest compromised blood flow under ischemic conditions?", "Can you see increased infiltration of immune cells or signs of cytokine release, consistent with an inflammatory response in autoimmune disorders?", "Is there evidence of abnormal tissue connections or fibrin deposition that might indicate adhesion formation following injury?", "Does the image display disruption of normal tissue architecture or infiltration by neoplastic cells, suggesting functional alteration due to tumor invasion?"], "functions": ["Is there a connective layer beneath the outermost surface of an organ that appears to provide structural support?", "Can you identify a tissue that might allow the outer layers of an organ to glide smoothly over nearby structures, suggesting mobility or flexibility?", "Does the image show a layer that appears to anchor the outermost surface of an organ to deeper muscular or connective tissues, providing attachment or stability?", "Is there evidence of a cushioning layer that could protect underlying organs from mechanical stress?", "Can you see a region that might facilitate fluid exchange or absorption, possibly through a loose connective matrix?", "Is there a layer supporting the vascular or lymphatic networks just beneath the organ's outer surface?", "Does the image show a tissue that could serve as a site for immune cell infiltration or fibrotic repair in response to inflammation or injury?", "Can you identify a structure that accommodates changes in organ volume, suggesting a role in expansion or contraction regulation?"]}, "no_questions": {"contexual_properties": ["Can you identify an area that shows evidence of calcium salt deposition or calcification within necrotic fat tissue?", "Does the image reveal any regions with a yellow, white, or chalky appearance suggestive of hemoglobin breakdown or lipid oxidation?", "Is there evidence of fibroblast proliferation or collagen deposition, indicating ongoing healing and fibrosis?"], "properties": ["Does the image reveal calcified areas that could be composed of calcium soaps formed by saponification?", "Is there an area that appears to have a normal temperature, unless there are signs of localized warmth from inflammation?", "Can you identify a region with a pale yellow or chalky white appearance?"], "relational": ["Is there a region in the image where adipocytes appear disrupted or replaced by other cell types such as macrophages or multinucleated giant cells?", "Does the image show evidence of tissue destruction within adipose or subcutaneous regions?", "Does the image show changes in tissues that could impact the integumentary, digestive, or endocrine systems?"], "contexual_behavior": ["Does the image suggest that the function of surrounding organs is altered due to mass effect from palpable lumps or compressed structures?", "Are there signs of disrupted fat absorption in the vicinity of pancreatic injury, such as digested peripancreatic fat?", "Are there signs of altered release of inflammatory mediators, such as increased cytokine or chemokine presence in damaged fat?"], "functions": ["Is there visual evidence of free fatty acid release or the formation of fatty acid-calcium complexes, such as saponification?", "Does the image suggest delayed tissue repair or the presence of chronic inflammation or scar formation?", "Is there an area where cell death, inflammation, or changes in the extracellular matrix are apparent?"]}}, "whorled appearance": {"yes_questions": {"contexual_properties": ["Does the image display any structures with a spiral or circular pattern?", "Can you identify an area where the arrangement of cells or fibers forms a swirling configuration?", "Is there a region in the image where elements are organized in a concentric or whorled manner?", "Does the image contain any tissue patterns that resemble a vortex or whirlpool shape?"], "properties": ["Does the image show a structure with a spiral or concentric circular pattern?", "Can you identify an area that appears round or oval in shape?", "Is there a region that looks pale, white, or tan compared to surrounding tissue?", "Does the image contain a structure that seems firm and rubbery in texture?", "Can you see an area that appears denser or more compact than adjacent tissue?", "Is there a visible pattern formed by bundles of collagen fibers and spindle-shaped cells?", "Do you observe cells arranged in concentric or spiral layers within any structure?", "Is there a region where fibers are oriented circumferentially or spirally around a central point?", "Can you find a pattern commonly seen in histological samples of uterine leiomyomas or nerve sheath tumors?", "Is there a structure whose size could be measured in millimeters or centimeters and varies depending on tissue context?"], "relational": ["Does the image show tissue with interlacing bundles or spiral arrangements?", "Can you identify a region with concentric layers within the tissue?", "Is there a structure composed of smooth muscle, fibrous, or neural tissue displaying a distinctive pattern?", "Does the image contain an area from the uterus, skin, or central nervous system with a unique organization?", "Can you see cells such as smooth muscle cells, Schwann cells, or fibroblasts arranged in a circular or spiral pattern?", "Is there a mass or lesion resembling a fibroid, schwannoma, or meningioma present?", "Does the tissue organization suggest the presence of connective tissue bundles or collagen fibers arranged in a patterned manner?", "Can you identify a morphological pattern similar to storiform, fascicular, or palisading arrangements?", "Is there evidence of a lesion within the muscularis layer, dermis, or submucosa that exhibits a distinctive structural pattern?", "Does the image show a larger structure like a leiomyoma, neurofibroma, or meningioma containing areas with a patterned organization?"], "contexual_behavior": ["Does the image show a pattern that becomes more pronounced during tissue remodeling with increased collagen deposition?", "Can you identify an area where the organization of collagen fibers suggests ongoing fibrosis?", "Is there evidence of a pattern that would diminish following anti-fibrotic therapy and normalization of tissue architecture?", "Does the image display concentric arrangements of spindle-shaped cells, as might be seen in certain tumors?", "Can you see a pattern that could result from abnormal cell proliferation?", "Is there a disruption of normal tissue patterns that might be explained by chronic inflammation and matrix remodeling?", "Does the image show a loss of organized growth and tissue invasion, as would be expected in malignant transformation?", "Can you identify spiral or concentric arrangements of collagen in fibrous tissue that might result from mechanical stress?", "Is there a visible pattern that could be altered by hormonal fluctuations affecting stromal and cellular organization?", "Does the image lack organized fiber arrangements, as might occur in genetic connective tissue disorders with collagen defects?", "Is there evidence of abnormal fiber aggregation and patterning that could be more evident in degenerative diseases?", "Can you see spiral or concentric collagen organization that might be associated with wound healing or scar formation?"], "functions": ["Does the image show a tissue organization pattern that suggests enhanced structural support?", "Can you identify an area where cell alignment or orientation appears organized in a spiral or circular fashion?", "Is there a region where the arrangement of cells or extracellular matrix could influence mechanical strength?", "Does the image display a pattern that might indicate altered proliferation or growth direction of cells?", "Can you see evidence of patterned growth that could reflect either normal development or a pathological process?", "Is there a structure that appears resilient to mechanical stress due to its organized pattern?", "Does the image contain features that could be associated with specialized tissue functions resulting from unique organization?", "Can you identify a region where morphogenesis, fibrosis, or neoplastic transformation might be suggested by the tissue pattern?", "Is there a visible arrangement that could affect cell-cell interactions or signaling pathways?", "Does the image show a pattern that might direct extracellular matrix remodeling or new cell orientation?", "Can you observe any features that suggest regulation of tissue structure or function through organized cellular arrangement?"]}, "no_questions": {"contexual_properties": [], "properties": ["Are there nuclear structures that could contain approximately 70\u201380% water by weight?", "Is there evidence of inclusions containing high concentrations of ribosomal RNA or precursor rRNA?", "Can you identify one to several basophilic inclusions per nucleus when stained with hematoxylin and eosin?"], "relational": ["Does the image show a subnuclear structure located within the nucleus of a eukaryotic cell?", "Is there evidence of interaction between a subnuclear structure and the nuclear envelope or nucleoplasm?", "Can you identify a structure within the nucleus that is structurally connected to chromatin through nucleolar organizer regions?"], "contexual_behavior": ["Is there a subcellular structure that appears enlarged in regions of rapid cell proliferation or growth stimulation?", "Does the image contain a component whose activity is reduced during oxidative stress to limit cellular damage?", "Is there evidence of a subcellular component that changes its function during apoptosis, such as reorganization or degradation of its parts?"], "functions": ["Can you identify an area involved in transcribing rRNA genes and assembling ribosomal subunits?", "Is there evidence of a structure that alters its appearance or function in response to cellular stress?", "Can you identify a site where small nucleolar ribonucleoproteins are assembled and matured?"]}}, "cut section": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an object in the image that appears to be between 3 and 5 millimeters thick?", "Can you identify a structure whose length is likely between 1 and 5 centimeters?", "Does the image show something with a width in the range of 1 to 3 centimeters?", "Is there a feature that has a rectangular or oval shape, reflecting the geometry of original tissue?", "Can you see a surface that appears smooth, or possibly granular or uneven depending on the tissue type?", "Is there an area displaying a color that ranges from pale pink to reddish-brown?", "Does the image contain an object whose estimated weight could be between 0.5 and 5 grams based on its size and tissue density?", "Can you identify a structure that might have a density between 1.03 and 1.06 grams per cubic centimeter, consistent with biological tissue?", "Is there a region composed of cellular elements, extracellular matrix, and interstitial fluid?", "Does the image show a moist area, suggesting a moisture content of approximately 70% to 80% by weight?", "Is there a structure that appears to be at room temperature or slightly cooler, as would be expected if freshly prepared?", "Can you identify an object whose pH would likely be near neutral, between 7.2 and 7.4?", "Is there a feature with sharp, well-defined edges, indicating it was cut cleanly?", "Does the image show a structure that maintains its integrity but may appear fragile depending on the tissue type?", "Can you see an area whose surface measures between 1 and 15 square centimeters?"], "relational": ["Does the image display a physical slice that reveals the internal organization of anatomical structures?", "Can you identify organs, blood vessels, nerves, or cavities exposed by a cross-sectional view?", "Are there visible tissues such as epithelial, muscle, connective, or nervous tissue in the image?", "Does the image show regions from the head, thorax, abdomen, or limbs in a sectional representation?", "Can you see features belonging to the digestive, nervous, cardiovascular, or musculoskeletal systems as revealed by a cross-section?", "Are there distinct layers such as mucosa, submucosa, muscularis, or serosa visible within an organ in the image?", "Does the image appear to be oriented along a sagittal, coronal, or transverse anatomical plane?", "Can you identify neighboring organs, surrounding tissues, blood vessels, or fascia adjacent to the main structure in the image?", "Are cell types such as epithelial cells, muscle cells, fibroblasts, or neurons visible in the sectioned area?", "Can you see connective tissues like loose connective tissue, dense connective tissue, adipose tissue, or cartilage within the section?"], "contexual_behavior": ["Does the image show evidence of impaired tissue repair that could be due to microbial contamination?", "Is there a visible area where clot formation appears delayed, possibly indicating a bleeding disorder?", "Can you identify a region where healing seems accelerated, suggesting optimal nutritional support?", "Does the image display signs of excessive inflammation that might be associated with autoimmune disease?", "Is there an area where tissue regeneration appears to have failed, as seen in chronic wounds?", "Can you observe features suggesting reduced blood flow, such as pallor or tissue ischemia, which may indicate vascular disease?", "Does the image reveal increased scarring or excessive fibrous tissue that could be due to abnormal collagen deposition in fibrotic conditions?", "Is there evidence of compromised barrier function that might be related to hyperglycemia, as seen in diabetes?", "Can you detect abnormal tissue remodeling that could be influenced by tumor-associated factors in a cancerous environment?", "Does the image suggest delayed healing or reduced cellular proliferation, potentially reflecting age-related changes in an elderly individual?", "Is there a region that appears more susceptible to infection, possibly due to impaired immunity in an immunocompromised state?", "Can you see signs of rapid closure or enhanced cell proliferation that might be stimulated by growth factors?", "Does the image show persistent bleeding that could be explained by insufficient or dysfunctional clotting factors, as in coagulopathy?", "Is there evidence of altered healing dynamics, such as suppressed repair or reduced inflammation, that could be associated with corticosteroid therapy?", "Can you observe enhanced formation of new blood vessels, indicating neovascularization during wound repair?"], "functions": ["Does the image display a view that exposes internal structures for detailed examination?", "Can you see an arrangement of tissues that reveals their spatial organization or layering within an organ?", "Is there a perspective that allows direct observation of abnormal features such as lesions or tumors?", "Does the image provide a way to assess morphological changes that could indicate disease progression?", "Can you observe details that would allow analysis of cellular composition or tissue integrity?", "Is there a view that helps correlate anatomical features with physiological functions by exposing internal architecture?", "Does the image reveal characteristic patterns that could assist in diagnosing a medical condition?", "Can you identify blood vessels or vascular patterns that highlight areas of perfusion or ischemia?", "Is there evidence of tissue viability, such as preserved architecture or signs of necrosis or hemorrhage?", "Does the image allow evaluation of the extent or distribution of infections or tumor invasion within tissues?"]}, "no_questions": {"contexual_properties": ["Does the image display a condition where the rectus muscles are not closely approximated at the midline?", "Does the image show a separation between the left and right sides of the rectus abdominis muscle?", "Is there evidence of a widened linea alba in the abdominal region?"], "properties": ["Is there a visible bulge or ridge along the midline of the abdomen, especially when the subject is straining?", "Does the image suggest that the intra-abdominal pressure at rest is within the normal range of 5 to 7 mmHg?", "Can you detect changes in the organization or content of collagen in the midline connective tissue?"], "relational": ["Does the image display an abnormal gap in the region associated with the linea alba?", "Are there signs of separation involving layers of the anterior abdominal wall?", "Does the image show changes in the relationship between the rectus abdominis and adjacent muscles such as the transversus abdominis or obliques?"], "contexual_behavior": ["Does the image indicate altered breathing mechanics during exertion, possibly due to a weakened abdominal wall?", "Does the image suggest interference with normal bowel or bladder function under strain, possibly due to a weakened abdominal wall unable to support pelvic organs?", "Are there signs that targeted physical therapy could improve the condition by strengthening the deep core and promoting tissue healing?"], "functions": ["Is there visual evidence of reduced functional strength of the abdominal wall that could impair physical performance?", "Is there a visible impairment in the coordination or force transmission of the abdominal muscles?", "Can you observe signs of reduced efficiency in trunk flexion or extension?"]}}}
[ { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "feet" ], "question": "is feet present?" }, { "answer": "stomach", "extracted_concepts": [ "stomach" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "stomach" ], "question": "is stomach present?" }, { "answer": "no", "extracted_concepts": [ "serous cystadenoma" ], "question": "is serous cystadenoma present?" }, { "answer": "hypertrophic gastritis", "extracted_concepts": [ "hypertrophic gastritis" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "hypertrophic gastritis" ], "question": "is hypertrophic gastritis present?" }, { "answer": "no", "extracted_concepts": [ "cystadenocarcinoma", "malignancy" ], "question": "is cystadenocarcinoma malignancy present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "stomach", "extracted_concepts": [ "stomach" ], "question": "what is present?" }, { "answer": "hypertrophic gastritis", "extracted_concepts": [ "hypertrophic gastritis" ], "question": "what is present?" } ]	["hypertrophic gastritis", "feet", "cystadenocarcinoma", "malignancy", "serous cystadenoma", "stomach", "gastrointestinal", "gastrointestinal system"]	{"hypertrophic gastritis": {"yes_questions": {"contexual_properties": ["Does the image show a region of the stomach with unusually thickened mucosa?", "Can you identify areas where the gastric folds appear enlarged or more prominent than normal?", "Is there evidence of increased mucus production, such as a visibly thick or glossy stomach lining?", "Does the stomach lining appear edematous or swollen, suggesting active inflammation?", "Can you observe signs that might indicate protein loss, such as exudative material or changes in mucosal texture?", "Is there a nodular appearance to the stomach wall, possibly due to irregular mucosal thickening?", "Are the rugae of the stomach visibly enlarged or hypertrophied on the image?", "Does the stomach cavity appear to contain an increased volume of fluid or gastric juice?", "Is the mucosa of the stomach pale or discolored, which could be associated with chronic inflammation or protein loss?", "Are there visual cues suggesting friability of the mucosa, such as areas that look easily disrupted or eroded?", "Can you detect excessive proliferation of the epithelial lining, such as foveolar hyperplasia?", "Is there evidence that acid secretion may be decreased, such as a lack of normal gastric secretions or changes in parietal cell regions?", "Does the image suggest fluid retention within the stomach due to mucosal edema?", "Are there signs of increased cellular infiltration in the mucosa, such as dense or irregular cellular patterns?"], "properties": [], "relational": ["Does the image show any abnormal changes in the digestive system?", "Can you identify alterations specifically in the body or fundus regions of the stomach?", "Is there visible thickening or hyperplasia of the gastric mucosal lining?", "Does the mucosal or submucosal layer of the stomach wall appear notably altered?", "Can you see evidence of changes in the fundic or pyloric glands within the stomach?", "Are there any visible differences in regions supplied by the left gastric artery, right gastric artery, or short gastric arteries?", "Does the image suggest involvement of lymphatic structures such as gastric or celiac lymph nodes near the stomach?", "Are there any notable interactions or proximity between the stomach and adjacent structures like the duodenum, pancreas, or lesser omentum?", "Can you observe any relationship between the stomach and the esophagus or duodenum in the image?", "Is there evidence of increased numbers of foveolar epithelial cells, parietal cells, chief cells, or infiltrating inflammatory cells in the affected stomach region?"], "contexual_behavior": [], "functions": ["Does the image show evidence of thickened mucosal folds within the stomach?", "Can you identify regions where the gastric mucosa appears enlarged or abnormally thickened?", "Is there visual indication of altered gastric function, such as irregular mucosal patterns?", "Does the image suggest changes that could be associated with increased or decreased gastric acid secretion?", "Can you see features that might indicate impaired nutrient absorption due to mucosal surface damage?", "Is there evidence of disruption to the protective barrier of the stomach lining, such as excessive mucus or epithelial irregularities?", "Does the image reveal signs of increased mucus secretion within the stomach?", "Can you identify any abnormalities that might reflect altered production of digestive enzymes like pepsinogen?", "Is there visual evidence of delayed gastric emptying or abnormal motility patterns in the stomach?", "Does the image suggest abnormal regulation of gastric hormones, such as changes in the appearance of hormone-producing regions?", "Can you observe increased infiltration of immune cells or signs of inflammation in the gastric mucosa?", "Is there any indication of protein loss from the stomach, such as excessive mucus accumulation or mucosal leakage?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image suggest that approximately 20 to 50 photographs are being taken as part of the process?", "Is there any indication that tissue samples weighing between 0.5 and 5 grams each are being collected?", "Can you see documentation or evidence of gross findings, microscopic examination, toxicology analysis, or photographic recording?"], "relational": ["Does the image show an examination that includes all major organ systems such as the cardiovascular or nervous system?", "Does the image suggest an investigation aimed at determining cause of death or identifying disease processes?", "Is there evidence of sampling different tissue types, for example, parenchymal or muscle tissue?"], "contexual_behavior": ["Do you see signs that prolonged refrigeration may have occurred, which could limit the detection of infectious agents due to decreased microbial viability or nucleic acid integrity?", "Can you identify any hidden structural or functional abnormalities that could help explain an unexplained sudden death?", "Can you identify visual cues that might indicate rapid identification of a novel pathogen is being prioritized?"], "functions": ["Does the image suggest activities aimed at detecting diagnostic errors or evaluating the accuracy of clinical care for quality assurance purposes?", "Does the scene suggest the identification of infections, malignancies, or chronic conditions that may not have been diagnosed before death?", "Can you see indications of uncovering hidden diseases or abnormalities that might have been missed during life?"]}}, "feet": {"yes_questions": {"contexual_properties": ["Does the image show a body part that appears swollen, possibly indicating edema or heart failure?", "Can you identify a structure that has changed color, which might suggest poor circulation or cyanosis?", "Is there an area that looks enlarged, potentially due to inflammation or trauma?", "Does the image contain a region that seems to have lost volume, as seen in muscle atrophy or malnutrition?", "Can you observe thickened or roughened skin that could result from repeated friction or pressure?", "Is there visible discoloration that might be associated with vascular disorders or fungal infections?", "Does the image show any open sores or ulcers that could be related to diabetes mellitus or peripheral artery disease?", "Can you identify a region that appears colder than surrounding areas, possibly due to reduced blood flow?", "Is there an area that looks unusually warm, which could indicate infection or inflammation?", "Does the image show evidence of fluid accumulation, as might occur in renal dysfunction or heart failure?", "Can you see abnormal skin texture, such as scaling or thickening, that could be due to psoriasis or chronic pressure?", "Is there visible dryness or cracking that might result from environmental exposure or eczema?", "Does the image reveal any areas that might have lost sensation, as seen in peripheral neuropathy?", "Can you identify blisters that could be caused by friction or burns?", "Is there a noticeable change in shape, possibly due to arthritis or congenital deformities?", "Does the image show deformities such as bunions or hammertoes?", "Are there visible changes in nail appearance, such as thickening or discoloration, that could indicate fungal infection or trauma?", "Can you observe pallor that might suggest anemia or acute arterial occlusion?", "Is there evidence of thickened skin, as seen in corns or chronic pressure areas?", "Does the image show reduced muscle mass, which could result from prolonged immobilization or neuromuscular disease?"], "properties": [], "relational": ["Does the image show a structure that is part of both the musculoskeletal and integumentary systems?", "Can you identify an area containing tarsal, metatarsal, and phalangeal bones?", "Is there a region that includes joints such as the ankle joint or metatarsophalangeal joints?", "Does the image display a structure connected to muscles like the flexor digitorum brevis or abductor hallucis?", "Can you see an area that would receive nerve supply from the tibial or common peroneal nerves?", "Is there a visible structure supplied by arteries such as the dorsalis pedis or posterior tibial artery?", "Does the image show a region supported by ligaments like the plantar fascia or long plantar ligament?", "Can you identify a structure associated with tendons such as the Achilles tendon or peroneal tendons?", "Is there an area anatomically adjacent to the ankles and lower legs?", "Does the image include a region where the surface is formed by skin, subcutaneous tissue, and epidermis?", "Can you see a structure that is connected to the ankles through articulations or structural continuity?", "Is there a region joined to the legs by the ankle joint and connective tissues?", "Does the image show compartments such as medial, lateral, central, or interosseous compartments within a structure?"], "contexual_behavior": ["Does the image show a structure that might provide less support if muscle weakness or joint instability were present?", "Is there evidence of a body part that could lose its shock-absorbing ability due to fat pad atrophy or collapsed arches?", "Can you identify a structure whose balance might be impaired in the presence of peripheral neuropathy?", "Does the image include a region that could show reduced circulation in response to cold exposure?", "Is there a visible area that might exhibit decreased sensation as a result of chronic hyperglycemia?", "Can you see a structure that could lose flexibility due to joint inflammation or cartilage degeneration?", "Does the image contain a part that might be less effective at regulating temperature if sweat gland function is impaired?", "Is there a region that could fail to maintain normal movement patterns after injury or swelling?", "Can you identify a structure that might increase sweat production during exercise?", "Does the image show a body part that could have reduced propulsion if muscle strength or tendon function were compromised?", "Is there a region that might display impaired wound healing in the context of poor circulation?", "Can you see a structure that could alter its load-bearing function due to increased body weight?", "Does the image include a part that might lose its protective function if tissue perfusion is insufficient?", "Is there a visible area that could experience decreased muscle activity during prolonged immobility?", "Can you identify a structure that might become less responsive to proprioceptive input with aging?"], "functions": ["Is there a structure in the image that provides support and helps maintain balance for the body?", "Can you identify an anatomical feature responsible for distributing body weight through arches during standing or walking?", "Does the image show a part that contributes to stability by offering a broad base of support?", "Is there an object that facilitates locomotion by enabling push-off and stride?", "Can you see a structure that absorbs shock during movement, possibly through elastic arches or soft tissue cushioning?", "Is there a feature that helps maintain posture by making micro-adjustments to body alignment?", "Does the image include a part that generates force for propulsion during running or jumping, especially through the forefoot or toes?", "Can you identify a structure that adapts to different surfaces by altering pressure distribution and adjusting joint angles?", "Is there an anatomical region that provides sensory feedback for movement control via mechanoreceptors in the skin or joints?", "Does the image show an area involved in temperature regulation by dissipating heat through sweat glands?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show an area of tissue that appears dark brown, black, or greenish in color?", "Is there visual evidence of gas accumulation, such as bubbles or swelling, that could indicate gas-producing bacteria?", "Can you see an area of tissue that appears cooler or less perfused than the surrounding healthy tissue?"], "relational": ["Is there visible involvement of the lower limbs, toes, fingers, or feet in the abnormality present?", "Can you observe necrosis, ulceration, or tissue breakdown involving the skin?", "Does the image show evidence of tissue damage affecting the skin, subcutaneous tissue, or muscle?"], "contexual_behavior": [], "functions": ["Does the image show signs of reduced phagocytic activity, disrupted barrier integrity, or increased pathogen invasion at a local site?", "Does the image show signs of disrupted blood supply, such as vascular occlusion or impaired perfusion?", "Can you identify an area where oxygen deprivation or irreversible tissue damage is apparent?"]}}, "cystadenocarcinoma": {"yes_questions": {"contexual_properties": ["Is there a lesion in the image that appears to be increasing in size due to cell proliferation?", "Can you identify a structure that has multiple compartments separated by internal septations?", "Does the image show a mass with both cystic and solid components, suggesting malignant transformation?", "Is there evidence of calcification within a tumor, possibly indicating necrosis or tissue degeneration?", "Can you observe changes in texture within a lesion, such as areas of fibrosis, necrosis, or increased cellularity?", "Does the image reveal a mass with increased vascularity, possibly due to angiogenesis?", "Are there regions within a lesion that appear necrotic, suggesting rapid growth outpacing blood supply?", "Can you see evidence of increased mucin content within a cystic mass?", "Is there a lesion that appears hemorrhagic, possibly due to ruptured or invaded blood vessels?", "Does the color of a mass vary, potentially due to hemorrhage, necrosis, or increased vascularity?", "Are papillary or finger-like projections visible along the wall of a cystic structure?", "Can you identify a mass that appears to have increased in weight due to cellular proliferation or fluid accumulation?", "Does the image show a lesion with increased cellular atypia, indicating malignant progression?", "Are there areas within a mass showing high mitotic activity or rapid cell division?", "Can you observe a lesion that appears to be infiltrating or invading surrounding tissues?", "Is there evidence of cystic degeneration, such as breakdown of tumor tissue or areas lacking blood supply?", "Does the wall of a cystic structure appear thickened, possibly due to fibrosis, inflammation, or proliferation?", "Can you see accumulation of fluid or mucin within cystic spaces of a lesion?", "Is there visual evidence suggesting abnormal biomarker expression, such as diagnostic staining or labeling?", "Does the lesion have an irregular or asymmetric shape, possibly due to uneven growth or tissue invasion?"], "properties": ["Is there a mass in the image that appears larger than 3 centimeters in diameter?", "Can you identify a lesion with multiple cystic spaces, possibly more than five per tumor?", "Does the image show a structure with irregular or lobulated contours?", "Is there a mass that seems to weigh between 100 grams and several kilograms based on its size?", "Can you see a tumor with areas that are grayish-white, tan, or yellow in color?", "Is there a structure that appears to have both soft and firm regions, with a mixture of cystic and solid components?", "Does the image contain a mass with cystic fluid that looks clear, straw-colored, or gelatinous?", "Can you identify tissue that might be lined by serous or mucinous glandular epithelium?", "Is there evidence of a tumor with a high number of mitotic figures, suggesting a high mitotic index?", "Does the image show cells with a noticeably increased nuclear-to-cytoplasmic ratio?", "Is there a mass that could be classified as high-grade based on its features?", "Can you see evidence of abundant mucin within the lesion, especially if it appears gelatinous?", "Is there a tumor with moderate to marked vascularity visible in the image?", "Does the tissue appear to have moderate fibrous stroma separating cystic spaces?", "Is there a region within the mass that appears necrotic, possibly comprising 10\u201330% of the tumor?", "Can you identify features that might indicate marked cellular atypia?", "Is there a structure that could express tumor markers such as CA-125 or CEA at moderate to high levels?", "Does the image show evidence of aneuploid nuclei within the tumor cells?", "Is there a lesion with a high Ki-67 proliferation index, possibly above 20%?", "Can you infer that the pH of the cystic fluid in the mass is mildly acidic to neutral, between 6.5 and 7.0?"], "relational": ["Does the image show a mass that appears to originate from epithelial tissue lining a glandular organ?", "Is there a lesion present in the ovary, pancreas, or liver?", "Can you identify an abnormal structure located within the abdominal or pelvic cavity?", "Does the image reveal a mass composed of malignant epithelial cells or stromal cells?", "Is there evidence of connective tissue, adjacent organs, or serosal membranes surrounding a suspicious lesion?", "Can you see regional lymph nodes or lymphatic vessels in proximity to an abnormal mass?", "Is there a structure that could indicate involvement of the lymphatic system, circulatory system, or peritoneal cavity in the spread of disease?", "Does the image show a lesion whose boundaries are defined by an organ capsule, surrounding tissues, or a serosal surface?", "Are there visible blood vessels such as the ovarian artery, hepatic artery, or pancreatic arteries supplying a mass in the image?", "Can you identify invasion of parenchymal tissue, peritoneum, or nearby organs like the bowel or bladder by an abnormal structure?"], "contexual_behavior": ["Is there evidence of a structure showing increased invasion into surrounding tissues, which could suggest advanced tumor progression or reduced cell adhesion?", "Can you identify a region with enhanced blood vessel formation, possibly indicating angiogenesis under low oxygen conditions?", "Does the image display features consistent with reduced cell proliferation, which might occur after exposure to cytotoxic drugs?", "Is there a structure that could be evading immune cell attack, potentially through upregulation of checkpoint molecules or reduced antigen presentation?", "Can you see signs of decreased mucin secretion, which might result from targeted therapy affecting mucin-producing pathways?", "Is there evidence of increased metastatic spread, possibly associated with chronic inflammation or cytokine activity in the tumor microenvironment?", "Does the image suggest altered metabolic activity, such as increased glycolysis, which may occur in nutrient-deprived or hypoxic regions?", "Can you identify areas where cells appear resistant to apoptosis despite signs of DNA damage, possibly due to overexpression of anti-apoptotic proteins?", "Is there a region that may be showing increased proliferation or survival, potentially due to upregulated growth factor signaling during tumor progression?", "Does the image suggest reduced sensitivity to hormonal regulation, which could be due to loss or alteration of hormone receptor expression?", "Can you observe evidence of extracellular matrix degradation, possibly due to increased production of proteolytic enzymes during tissue invasion?", "Is there a reduction in cell proliferation or signs of senescence that might be associated with DNA damage from radiation therapy?", "Does the structure appear to be modifying its immune evasion strategies, such as by altering antigen presentation or expressing inhibitory ligands, possibly in response to immunotherapy?", "Is there visual evidence of increased glycolytic activity in areas with low oxygen, which could be due to activation of hypoxia-inducible factors?", "Can you identify regions with impaired cell adhesion, potentially due to downregulation of adhesion molecules like E-cadherin during epithelial-mesenchymal transition?", "Is there evidence of enhanced secretion of pro-inflammatory cytokines within the tumor microenvironment, possibly during interactions with immune or stromal cells?", "Does the image show reduced growth or limited blood vessel formation, which could be a result of anti-angiogenic therapy?", "Can you observe increased invasive behavior that might be linked to loss of tumor suppressor function, such as inactivation of p53 or PTEN?", "Is there evidence of upregulated antioxidant defenses or stress response pathways, possibly indicating an adaptive response to oxidative stress during tumor progression?", "Does the structure show signs of impaired DNA repair, which might be observed after exposure to genotoxic agents?"], "functions": ["Does the image show a structure exhibiting signs of malignant growth, such as local invasion or potential spread to distant sites?", "Is there evidence of tissue infiltration or degradation of the extracellular matrix by an abnormal mass?", "Can you identify an area where healthy tissue appears to be replaced by abnormal cells, potentially leading to organ dysfunction?", "Does the image reveal regions with increased blood vessel formation, possibly indicating neovascularization stimulated by secreted factors?", "Is there a structure that might be evading immune detection, for example by showing reduced immune cell infiltration or altered immune response?", "Can you observe features suggesting tumor cell detachment or possible entry into blood vessels, which could indicate metastatic potential?", "Does the image display signs of altered cellular signaling, such as abnormal growth patterns or loss of normal tissue architecture?", "Is there evidence of disrupted tissue homeostasis, such as architectural distortion or abnormal cell turnover?", "Can you see indications of local or systemic inflammation, such as increased immune cell presence or tissue swelling?", "Does the image suggest modification of the tumor microenvironment, such as changes in extracellular matrix composition or interaction with stromal cells?", "Is there a region where cells appear resistant to programmed cell death, possibly indicated by dense cellularity or lack of apoptotic features?", "If the image includes an endocrine organ, is there evidence of disrupted hormone production or altered glandular structure?", "Can you identify areas with uncontrolled cell proliferation, such as regions with high cellular density or abnormal mitotic figures?", "Is there visual evidence of stromal cell activation, such as increased fibroblast presence or remodeling of the surrounding matrix?", "Does the image suggest increased nutrient or oxygen consumption by a mass, potentially leading to hypoxic regions or metabolic competition with normal tissue?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a feature in the image that would likely have a continuous body rather than distinct segments?", "Does the image contain an organism whose internal temperature would match that of a human host, around 36 to 37 degrees Celsius?", "Is there an object that could have a protein content of 10 to 20 percent and a fat content of 5 to 10 percent of its wet weight?"], "relational": ["Is there evidence of a parasite located in the large intestine?", "Is there a parasite interacting with the intestinal mucosa or perianal skin?", "Can you identify an organism associated with the cecum, colon, or rectum?"], "contexual_behavior": ["Is there evidence of migration toward the perianal region, especially during nighttime, to facilitate egg deposition?", "Is there evidence of decreased infectivity in a crowded host environment, possibly due to increased competition and limited resources?", "Can you see signs of increased transmission potential in conditions of poor hygiene or inadequate sanitation?"], "functions": ["Is there any indication of irritation or mild inflammation of the intestinal mucosa, possibly caused by a parasitic presence?", "Is there an organism attached to the intestinal mucosa by its anterior end, possibly moving by undulating its body?", "Does the image suggest the presence of an organism that could cause perianal itching or facilitate secondary bacterial infections due to scratching?"]}}, "malignancy": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to be increasing in size, suggesting rapid cell proliferation?", "Can you identify an area that has decreased in size, possibly indicating a response to treatment such as chemotherapy or surgical removal?", "Does the image show a mass with irregular or changing shape, consistent with invasion into surrounding tissues?", "Is there evidence of increased blood vessel formation supplying a mass, suggesting neovascularization?", "Can you see a region with noticeably higher cellular density compared to surrounding tissue?", "Is there a visible area of tissue death within a mass, possibly due to insufficient blood supply?", "Does the coloration of any structure appear altered, such as areas of hemorrhage or necrosis?", "Is there a mass that appears heterogeneous, with mixed regions of different textures or densities?", "Can you identify areas that might represent calcification within a mass, possibly due to mineral deposition?", "Is there evidence of a structure breaching normal tissue boundaries and infiltrating adjacent areas?", "Do you observe increased numbers of dividing cells within a particular region, suggesting a high mitotic rate?", "Is there disruption of normal tissue organization, indicating abnormal architecture?", "Does any area show signs of increased metabolic activity, such as features consistent with hypermetabolism?", "Is there a mass that appears encapsulated, possibly as a result of a host response to limit its spread?", "Can you see loss of normal boundaries between tissues, with one area replacing or invading another?", "Is there a region that appears stiffer or more fibrous, possibly due to a desmoplastic reaction?", "Do you observe cystic spaces or fluid-filled areas within a mass, suggesting degeneration or necrosis?", "Is there a change in surface texture, such as irregularity or fibrosis, on any visible mass?", "Can you identify areas of fluid accumulation or edema associated with a mass?", "Does the image suggest the presence of abnormal protein or metabolite expression, as might be detected by biomarker elevation?"], "properties": ["Is there a structure in the image that varies in size from a few millimeters to several centimeters?", "Can you identify an area that appears to have grown rapidly or could double in size within weeks to months?", "Does the image show a mass with irregular or poorly defined borders?", "Is there a region composed of densely packed cells, including possible immune or stromal cells?", "Can you see evidence of increased cell division, such as a high number of mitotic figures?", "Is there a cluster of cells with enlarged nuclei relative to their cytoplasm?", "Does the image contain a region that appears poorly differentiated or more aggressive in appearance?", "Can you identify cells that show marked pleomorphism or abnormal nuclear features?", "Is there an area that might display abnormal DNA content or changes in ploidy?", "Does the gross appearance include tan, gray, or white areas, possibly with regions of hemorrhage or necrosis?", "Is there a firm or hard mass that could be due to dense cellularity or desmoplastic stroma?", "Can you see evidence of increased or abnormal blood vessels, suggesting angiogenesis or fragile vasculature?", "Is there a region where necrosis appears to exceed 20% of the mass, especially in rapidly growing areas?", "Does the image suggest increased metabolic activity, such as regions that might take up more glucose?", "Can you identify an area where tumor marker expression might be elevated, such as CEA, AFP, or PSA?", "Is there a region with a proliferation index, such as Ki-67, that appears to be high or above 20%?", "Does the image show cells that have lost resemblance to their tissue of origin, indicating poor differentiation?", "Can you identify features that might be associated with mutations in oncogenes, tumor suppressor genes, or DNA repair genes?", "Is there evidence of high chromosomal instability, such as frequent structural or numerical chromosomal abnormalities?", "Does the image show a region with increased density due to high cellularity?"], "relational": ["Does the image show evidence of abnormal tissue affecting the respiratory or gastrointestinal system?", "Can you identify a lesion that appears to arise from epithelial, connective, hematopoietic, or neural tissue?", "Is there a mass or abnormality located in regions such as the lung, breast, colon, prostate, or skin?", "Does the image reveal a structure that appears to invade blood vessels, lymphatic vessels, or adjacent organs?", "Can you see any indication of lymphatic involvement, such as enlarged lymph nodes or new lymphatic vessels?", "Is there evidence of a lesion in organs commonly affected by secondary spread, such as the liver, lungs, bones, or brain?", "Does the image contain clusters of cells that could represent neoplastic, stromal, immune, or endothelial components?", "Can you observe anatomical barriers, such as basement membranes or organ capsules, that appear disrupted or breached?", "Is there any sign of abnormality that could impact the skeletal, central nervous, endocrine, or cardiovascular systems?", "Does the image show a structure that disrupts surrounding tissues through invasion, compression, or destruction?", "Can you identify features suggestive of new blood vessel formation within or around a suspicious lesion?"], "contexual_behavior": ["Is there evidence of a structure invading surrounding tissues, possibly influenced by factors like matrix metalloproteinases or epithelial-mesenchymal transition signals?", "Can you identify a region that appears resistant to immune cell infiltration, suggesting upregulation of immune checkpoint molecules or reduced antigen presentation?", "Does the image show a mass with features suggestive of increased motility or spread, which could be associated with hypoxic conditions and activation of hypoxia-inducible factors?", "Is there a visible area where cell proliferation appears reduced, potentially indicating the effects of targeted therapy or cell cycle arrest?", "Can you observe signs of altered metabolic activity, such as increased autophagy or adaptation to nutrient deprivation?", "Is there evidence of evasion of programmed cell death, possibly due to genetic alterations in regulators like TP53 or BCL-2?", "Does the image show increased blood vessel formation in regions of low oxygen, suggesting upregulation of vascular endothelial growth factor?", "Is there a noticeable decrease in growth rate or increased cellular senescence following exposure to chemotherapy?", "Can you identify areas with features of local immune suppression, such as the presence of regulatory immune cells or secretion of immunosuppressive cytokines?", "Is there evidence of a metabolic shift toward glycolysis, consistent with the Warburg effect, in regions of high metabolic demand or low oxygen?", "Does the structure display characteristics of impaired DNA repair, possibly due to mutations in genes like BRCA1 or mismatch repair proteins?", "Can you observe increased secretion of tissue remodeling factors, such as proteases or growth factors, in areas of invasion or metastasis?", "Is there evidence of altered cell signaling pathways, such as activation of NF-\u03baB or STAT3, in regions affected by chronic inflammation?", "Does the image suggest reduced responsiveness to hormonal regulation, possibly due to downregulation or mutation of hormone receptors?", "Can you identify regions with enhanced self-renewal capacity, potentially linked to activation of cancer stem cell pathways like Wnt, Notch, or Hedgehog?", "Is there evidence of decreased antigen presentation to immune cells, such as downregulation of MHC class I molecules?", "Does the structure show adaptation to changes in the surrounding microenvironment, including stromal signals, extracellular matrix composition, or immune cell infiltration?", "Can you observe features indicating increased resistance to oxidative stress, such as upregulation of antioxidant enzymes or activation of survival pathways?", "Is there evidence of growth independent of external signals, possibly due to activating mutations in growth factor receptors or downstream signaling molecules?", "Does the image show enhanced blood vessel formation during rapid expansion, suggesting secretion of pro-angiogenic factors and stimulation of endothelial cell proliferation?"], "functions": ["Does the image show evidence of a process characterized by uncontrolled cell proliferation or invasion into surrounding tissues?", "Can you identify a region where normal tissue architecture appears disrupted or replaced by abnormal cells?", "Is there visual evidence of a structure that may have breached basement membranes or invaded adjacent tissues?", "Does the image suggest the presence of cells that have intravasated into blood or lymphatic vessels, potentially indicating spread to distant sites?", "Can you see features that might indicate evasion of programmed cell death, such as dense clusters of abnormal cells persisting despite tissue damage?", "Is there an area where the normal organ structure is altered, possibly leading to organ dysfunction?", "Does the image reveal changes in the local tissue environment, such as increased stromal density or infiltration by immune cells?", "Can you identify regions with increased blood vessel formation, possibly due to the release of pro-angiogenic factors like VEGF?", "Is there evidence suggesting immune evasion, such as reduced immune cell infiltration or altered antigen presentation in certain areas?", "Does the image show signs of increased metabolic activity or altered nutrient utilization, such as regions with high cellular density and atypical morphology?", "Can you observe features that might indicate genetic instability, such as pleomorphic nuclei or abnormal mitotic figures?", "Is there visual evidence of abnormal activation of cellular signaling pathways, such as areas with rapid cell division or loss of differentiation?", "Does the image suggest systemic effects like cachexia, for example, by showing tissue wasting or inflammation in the surrounding area?", "Can you identify features that might indicate resistance to therapy, such as persistent abnormal cell populations despite evidence of treatment?", "Is there evidence of dedifferentiation or the presence of cells with stem-like characteristics, such as poorly differentiated or undifferentiated cell clusters?"]}, "no_questions": {"contexual_properties": ["Does the image contain features consistent with reactive epithelial changes due to inflammation?", "Is there evidence of architectural distortion that could indicate invasive carcinoma or complex hyperplasia?", "Is there evidence of glandular crowding that becomes more pronounced in high-grade dysplasia or malignant lesions?"], "properties": ["Is there evidence of glands that are small to medium in size with irregular outlines?", "Can you identify a region where the number of glands per unit area appears significantly increased, possibly exceeding 10 per low-power field?", "Is the distance between adjacent glands reduced, with minimal or no stroma separating them?"], "relational": ["Does the image show regions where glands are closely packed with little separation by stromal tissue?", "Does the image display glandular proliferation within an organ parenchyma or epithelial compartment?", "Is there evidence of altered glandular architecture, such as overlapping glandular profiles?"], "contexual_behavior": ["Does the image display an increased number of glandular cells within a confined space, indicating possible hyperplasia and architectural disruption?", "Can you observe a decrease in glandular crowding that might be associated with effective treatment or resolution of inflammation?", "Is there a visible area where abnormal cell growth and loss of normal tissue constraints suggest a neoplastic process?"], "functions": ["Are there areas where glandular cells appear to be in closer proximity, possibly affecting cell-cell interactions or paracrine signaling?", "Does the image suggest compromised nutrient or oxygen delivery, such as reduced vascular supply to densely packed glandular regions?", "Is there evidence of impaired secretion, such as glands with obstructed or narrowed lumens?"]}}, "serous cystadenoma": {"yes_questions": {"contexual_properties": ["Is there a cystic structure in the image that appears to have increased in size, possibly due to fluid accumulation or hormonal effects?", "Can you identify a lesion that may have decreased in size, suggesting prior rupture, aspiration, or regression?", "Does the image show a cystic mass with multiple internal compartments or septations, indicating multilocularity?", "Is there evidence of internal septa or microcyst formation within a cystic lesion?", "Can you see a cystic structure with changes in fluid characteristics, such as altered clarity or color, which might suggest hemorrhage, infection, or inflammation?", "Is there a cystic mass with visible calcifications, possibly indicating chronicity or degeneration?", "Does the image show a cystic lesion with areas of hemorrhage, such as internal bleeding or color changes, potentially due to trauma or vascular injury?", "Can you identify a cystic structure with thickened walls, which could be due to inflammation, infection, or neoplastic transformation?", "Is there a cystic lesion that appears more solid in certain regions, possibly due to fibrous tissue proliferation or scarring?", "Does the image show a cystic mass with internal fibrous septa or evidence of repeated cystic division?", "Is there a cystic structure with increased vascularity, such as prominent blood vessels, which might indicate rapid growth, inflammation, or neoplastic progression?", "Can you see a cystic lesion that appears irregular in shape, possibly due to uneven growth, scarring, or partial collapse?", "Is there a cystic mass with rare papillary projections, suggesting atypical epithelial proliferation or neoplastic change?", "Does the image show a cystic structure with changes in fluid clarity, such as cloudiness or increased protein content, possibly due to hemorrhage or infection?", "Can you identify a cystic lesion that appears to have ruptured, as indicated by wall discontinuity or surrounding fluid, potentially due to overdistension, trauma, or infection?"], "properties": [], "relational": ["Does the image show a lesion affecting the reproductive system?", "Is there a structure present that is commonly associated with either the ovary or the pancreas?", "Can you identify a mass surrounded by tissues such as ovarian stroma or pancreatic parenchyma?", "Is there a lesion located near anatomical structures like the fallopian tube, uterus, mesentery, or duodenum?", "Does the image reveal a cystic area lined by epithelial or cuboidal cells?", "Is there a mass situated within the pelvic or abdominal cavity?", "Can you see a lesion supplied by the ovarian artery or pancreaticoduodenal artery?", "Is there evidence of a mass displacing ducts such as the fallopian tube, pancreatic duct, or bile duct?", "Does the image show a well-encapsulated lesion closely associated with an organ capsule?", "Is there a cystic neoplasm that appears structurally similar to a mucinous cystadenoma or Brenner tumor?"], "contexual_behavior": ["Does the image show a structure that appears to be secreting more fluid, possibly indicating active growth or a response to local irritation?", "Is there evidence of a mass compressing or displacing surrounding tissue, suggesting impaired normal tissue function?", "Can you identify a cystic lesion that seems to have reduced proliferative activity, possibly indicating a stable phase or response to therapy?", "Does the image suggest that a cystic structure is behaving differently, potentially due to hormonal changes such as those seen in pregnancy or hormonal therapy?", "Is there a mass that appears to be large enough to obstruct nearby ducts or vessels due to compression?", "Can you see signs of increased cystic fluid accumulation that might be associated with inflammation and enhanced vascular permeability?", "Does the image show a cystic lesion with decreased secretory activity, possibly following surgical removal or sclerotherapy?", "Is there evidence of disrupted local tissue metabolism, such as altered nutrient or oxygen exchange, near a cystic mass that invades or compresses adjacent tissues?", "Can you identify a cystic structure where the epithelial barrier may be compromised, possibly due to inflammation or necrosis?", "Is there a mass effect from a cystic lesion that increases pressure on adjacent organs or affects their function as it grows?", "Does the image suggest a cystic lesion with altered growth rate, potentially influenced by hormonal changes during pregnancy?", "Is there evidence of impaired fluid resorption within a cystic structure, possibly due to infection and resulting in further enlargement?", "Can you see a reduction in the impact of a cystic mass on organ function, possibly after surgical removal or decompression?", "Does the image show a cystic lesion with increased secretory activity in response to local inflammation?", "Is there evidence that lymphatic drainage is impaired in the region of a cystic mass, possibly due to compression or invasion of local lymphatic vessels?"], "functions": ["Is there a fluid-filled mass in the image that appears to be expanding but does not invade surrounding tissues?", "Can you identify a structure that seems to compress or displace nearby normal tissue, potentially affecting the function of the organ?", "Does the image show a cystic lesion characterized by the accumulation of clear fluid within its spaces?", "Is there evidence of local tissue architecture being distorted or disrupted by a mass effect?", "Can you see a structure that might be causing obstruction or altering the physiology of the affected organ due to its size or position?", "Does the image contain a mass that interacts with adjacent tissues mainly by expansion and compression, rather than by direct invasion?", "Is there a lesion whose growth appears to be due to both epithelial cell proliferation and fluid accumulation within cystic spaces?", "Can you observe abnormal proliferation of epithelial cells leading to disrupted tissue organization in the image?", "Does the image show progressive enlargement of an organ with associated structural distortion or compromised function?", "Is there visual evidence of altered tissue pressure, fluid imbalance, or modified cellular interactions in the local microenvironment surrounding a cystic mass?"]}, "no_questions": {"contexual_properties": ["Are there multiple horizontal lines or additional creases on the ear lobe that might suggest repetitive mechanical stress or further aging?", "Can you observe a horizontal line on the ear lobe that seems deeper in areas where the skin looks less elastic or thinner?", "Do you see any changes in the texture of a horizontal crease on the ear lobe, such as roughness or irregularity, that might suggest scarring, fibrosis, or chronic skin disease?"], "properties": ["Does the ear lobe display a crease with a width of about 1 to 2 millimeters?", "Can you identify a shallow crease, less than 1 millimeter deep, on the ear lobe?", "Does the image show a feature on the ear lobe that is more commonly seen in adults over 50 years of age?"], "relational": ["Can you see a structure adjacent to the lower margin of the auricle or near the preauricular region?", "Does the image display a marking that is part of the integumentary system and located on the external ear?", "Does the image show a surface marking located on the external ear?"], "contexual_behavior": ["Can you see a feature associated with impaired wound healing in conditions affecting vascular or connective tissue health?", "Is there a visible sign that can indicate altered connective tissue function in the context of metabolic syndrome?", "Is there a visible sign that could indicate impaired microcirculation due to reduced capillary blood flow in the tissue?"], "functions": ["Can you see a feature that, while having no known physiological function, is sometimes evaluated in medical examinations?", "Does the image show a physical feature that is sometimes considered during health assessments?", "Can you identify a visible sign that may be used as a clinical marker for certain conditions?"]}}, "stomach": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify an organ that is adjacent to the liver or pancreas?", "Is there a structure positioned near the spleen or transverse colon?", "Does the image display regions such as the cardia, fundus, body, antrum, or pylorus?", "Can you see evidence of blood supply from arteries like the left gastric or right gastric artery?", "Is there a structure that could be innervated by the vagus nerve or fibers from the celiac plexus?", "Does the image show a connection between the esophagus and another organ via a cardiac orifice?", "Can you identify a junction where the esophagus delivers ingested material to another structure?", "Is there a visible connection to the duodenum through a pyloric sphincter?", "Does the image reveal layers such as mucosa, submucosa, muscularis externa, or serosa in a wall of an organ?", "Can you see a lining that might contain parietal cells, chief cells, mucous cells, or enteroendocrine cells?", "Is there evidence of support or anchoring by the lesser omentum, greater omentum, or gastrosplenic ligament?", "Does the image show lymphatic structures such as gastric lymph nodes, gastroepiploic lymph nodes, or celiac lymph nodes near an organ?", "Can you identify an organ that interacts with both the esophagus and duodenum during digestion?", "Is there a structure in the image that could be involved in transferring contents from the esophagus to the small intestine?"], "contexual_behavior": [], "functions": ["Does the image show an organ responsible for storing ingested food before it enters the small intestine?", "Can you identify a structure that initiates the process of digestion?", "Is there an object that regulates the gradual passage of food into the small intestine?", "Does the image contain a structure that secretes gastric juices to aid in digestion?", "Can you see an organ that mechanically breaks down food through muscular contractions?", "Is there evidence of a structure that forms chyme by mixing food with digestive secretions?", "Does the image include a feature that controls the release of food via a sphincter at the junction with the small intestine?", "Can you identify a region where digestive enzymes like pepsinogen are secreted for protein breakdown?", "Is there a structure that produces hydrochloric acid to denature proteins and activate digestive enzymes?", "Does the image show an area where parietal cells might be present?", "Can you see a structure that creates an acidic environment to destroy ingested pathogens?", "Is there evidence of coordinated muscular contractions that mix and churn food with secretions?", "Does the image contain a region where substances such as alcohol or medications could be absorbed directly into the bloodstream?", "Can you identify an organ that releases hormones like ghrelin to regulate appetite?", "Is there a structure involved in the production of gastrin for hormonal regulation of digestion?", "Does the image show a region where pepsin is activated to hydrolyze proteins?", "Can you see an area that provides antimicrobial defense through high gastric acidity?"]}, "no_questions": {"contexual_properties": ["Is there a region that appears more infiltrated by fat, possibly reflecting aging, weight gain, or involutional changes?", "Is there a zone with increased density that could be associated with inflammatory processes, fibrosis, or neoplastic involvement?", "Can you see signs of increased water content, such as those associated with edema, inflammation, or lymphatic congestion?"], "properties": ["Does the image show a structure with a relatively low protein content, around 1\u20132% by weight?", "Is there a region where the fat or lipid content is estimated to be 80\u201390% of the tissue mass?", "Does the image contain a region where the radiodensity might fall between \u2013100 and \u201350 Hounsfield units?"], "relational": ["Is there a visible layer corresponding to subcutaneous fat or the retromammary space?", "Does the image show tissue associated with terminal duct lobular units or lactiferous ducts?", "Can you identify connective tissue composed mainly of collagen fibers or interlobular stroma?"], "contexual_behavior": [], "functions": ["Is there a structure that appears to influence fluid distribution through its extracellular matrix or vascular features?", "Does the image contain a scaffold-like area that helps maintain breast shape and resilience?", "Is there a region that could be involved in lipid storage or nutrient exchange, supporting metabolic activity?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": ["Are there visible macroscopic deposits or radiopaque areas that could indicate increased radiodensity from calcified fat?", "Is there visual evidence of organ involvement where abnormal deposits are present in association with tissue injury or disease progression?", "Can you identify regions that appear firmer or harder than surrounding tissue, possibly due to calcification in necrotic fat?"], "properties": ["Does the image show granular or chalky deposits within tissue?", "Are there deposits with a hardness similar to soft chalk?", "Do you see deposits ranging in size from micrometers to several millimeters?"], "relational": ["Is there a region in the digestive or integumentary system displaying signs of fat necrosis nodules or calcified lesions?", "Does the image show evidence of fat necrosis in tissues such as the pancreas or subcutaneous regions?", "Can you see any features suggestive of lipase activity leading to saponification within fatty tissue?"], "contexual_behavior": ["Can you identify changes in the intestinal lining that might indicate altered absorption of fat and calcium, such as those seen in intestinal inflammation?", "Does the image suggest reduced absorptive surface area in the intestine, as might occur after surgical resection, potentially leading to decreased formation of insoluble complexes?", "Is there visual evidence of large amounts of unabsorbed fat in the stool, which could promote the formation of insoluble complexes with intestinal calcium as seen in steatorrhea?"], "functions": ["Does the image suggest a process that regulates lipid metabolism by limiting the intestinal absorption of dietary fats?", "Is there any indication of altered mineral balance, possibly due to reduced bioavailability of dietary calcium and fatty acids?", "Does the image suggest the sequestration of long-chain fatty acids within the gut, potentially limiting their uptake?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a visible abnormality adjacent to joints such as the knee, elbow, or wrist?", "Does the image reveal changes in tissues like muscle, ligament, tendon, or skin near a bony structure?", "Is there a region, such as the forearm, hip, or spine, that appears particularly susceptible to structural disruption?"], "contexual_behavior": ["Can you identify a bone lesion that might demonstrate enhanced healing after physical or electrical stimulation therapy?", "Is there a bone injury that could show increased bone resorption during immobilization or disuse?", "Is there a bone injury whose repair process might be compromised after exposure to radiation due to cellular and vascular damage?"], "functions": ["Is there evidence of pain response, such as guarding posture or tissue sensitization, in the affected area?", "Can you observe any changes that might indicate an inflammatory response, such as increased tissue density or redness around a bone?", "Is there visual evidence of callus formation or new bone growth at a site of bone disruption?"]}}}
[ { "answer": "the tube and ovary to the left of the uterus", "extracted_concepts": [ "ovary", "uterus", "hemorrhagic inflammatory mass", "tube" ], "question": "what are totally obscured by a hemorrhagic inflammatory mass?" }, { "answer": "the hemorrhagic inflammatory mass", "extracted_concepts": [ "ovary", "uterus", "hemorrhagic inflammatory mass", "tube" ], "question": "what are the tube and ovary to the left of the uterus totally obscured by?" }, { "answer": "yes", "extracted_concepts": [ "ovary", "uterus", "hemorrhagic inflammatory mass", "tube" ], "question": "are the tube and ovary to the left of the uterus totally obscured by a hemorrhagic inflammatory mass?" }, { "answer": "no", "extracted_concepts": [ "hemorrhagic inflammatory mass", "edema" ], "question": "are edema totally obscured by a hemorrhagic inflammatory mass?" }, { "answer": "the tube", "extracted_concepts": [ "ovary", "adherent", "tube", "adjacent ovary" ], "question": "what is adherent to the adjacent ovary on the other side?" }, { "answer": "the adjacent ovary on the other side", "extracted_concepts": [ "tube", "adjacent ovary" ], "question": "what is the tube adherent to?" }, { "answer": "yes", "extracted_concepts": [ "ovary", "tube adherent to the adjacent ovary on the other side", "tube", "adjacent ovary" ], "question": "is the tube adherent to the adjacent ovary on the other side?" }, { "answer": "no", "extracted_concepts": [ "ovary", "adherent", "kidney" ], "question": "is the kidney adherent to the adjacent ovary on the other side?" } ]	["ovary", "uterus", "edema", "tube adherent to the adjacent ovary on the other side", "adjacent ovary", "adherent", "hemorrhagic inflammatory mass", "kidney", "tube"]	{"ovary": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears enlarged, which could suggest the presence of cysts, ovulation, or a tumor?", "Is there an organ that appears shrunken, possibly indicating menopause, surgical removal, or atrophy?", "Can you identify a structure with multiple cystic areas, as might be seen in polycystic ovary syndrome or functional cyst formation?", "Does the image reveal a change in tissue texture, such as increased firmness or irregularity, that could be due to fibrosis, cysts, or neoplastic processes?", "Is there evidence of increased vascularity in a structure, which might occur during ovulation, pregnancy, or in certain tumors?", "Can you see an organ with an unusually high number of follicles, as might be observed in ovarian hyperstimulation or polycystic conditions?", "Does the image show a reduction in follicle number, which could be associated with aging, menopause, or ovarian failure?", "Is there a visible change in color, such as areas of redness or pallor, that could indicate hemorrhage, infarction, or increased blood flow?", "Can you identify fluid accumulation within or around a structure, as might be seen with cysts, edema, or hyperstimulation syndrome?", "Does the image show signs of tissue fibrosis, possibly due to aging, chronic inflammation, or repeated ovulatory cycles?", "Is there evidence of calcifications within a structure, which could be related to tumors or chronic inflammation?", "Can you observe an increase in the weight or bulk of an organ, potentially due to cysts, tumors, or edema?", "Does the image suggest a decrease in organ weight, as might occur after menopause, surgical removal, or atrophy?", "Is there a structure that could be associated with abnormal hormone production, such as in endocrine disorders or certain tumors?", "Can you identify a solid mass within an organ, which could indicate a benign or malignant neoplasm?", "Does the image show an irregularly shaped structure, possibly due to cysts, tumors, or scarring?", "Is there evidence of altered tissue composition, such as areas of neoplastic transformation, fibrosis, or cyst formation?", "Can you see signs of edema or swelling in a structure, as might occur in hyperstimulation syndrome, inflammation, or torsion?", "Does the image reveal hemorrhagic areas, which could result from ruptured cysts, endometriosis, or trauma?", "Is there visible surface scarring on an organ, possibly due to repeated ovulation, surgical intervention, or inflammation?"], "properties": ["Is there a structure in the image that appears oval or almond-shaped?", "Can you identify an object with a whitish or grayish-pink hue?", "Does the image show a structure that is firm but slightly elastic in texture?", "Is there an object whose size falls within the range of 3 to 5 centimeters in length and 1.5 to 3 centimeters in width?", "Can you see a structure that might weigh between 5 and 8 grams in an adult woman?", "Does the image contain an object with a volume of approximately 6 to 10 cubic centimeters?", "Is there a structure that contains specialized cells such as oocytes or granulosa cells?", "Can you identify an object that may have several hundred to several hundred thousand small follicles, depending on age?", "Does the image show a structure that produces hormones like estrogen or progesterone?", "Is there an object with a high vascular density, indicated by a rich capillary network?", "Can you see a structure with substantial connective tissue, mainly composed of collagen and reticular fibers?", "Is there an object whose tissue density is close to 1.05 grams per cubic centimeter?", "Does the image show a structure that could have a water content of about 70 to 80 percent by weight?", "Is there an object that might contain 10 to 15 percent lipid and protein by wet weight?", "Can you identify a structure that maintains a physiological pH close to 7.3 to 7.4?", "Does the image contain an object with a temperature similar to core body temperature, around 37 degrees Celsius?", "Is there a structure that includes minerals such as calcium, phosphorus, potassium, and trace elements?", "Can you see an object that typically contains 5 to 25 antral follicles in reproductive-aged women?", "Is there a structure with significant cholesterol content, possibly around 10 to 20 milligrams per gram of tissue?"], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify an object located in the pelvic cavity?", "Is there a structure adjacent to the uterus or fallopian tube?", "Does the image contain something positioned near the urinary bladder?", "Can you see a structure supported by ligaments such as the ovarian ligament or broad ligament?", "Is there an object that receives blood supply from the ovarian artery or a branch of the uterine artery?", "Does the image show a structure connected to the uterine tube?", "Can you identify tissues such as an outer cortex, inner medulla, or a germinal epithelium layer?", "Is there a structure functionally or anatomically linked to the uterus via a ligament or tube?", "Does the image include an object adjacent to the pelvic wall or rectum?", "Can you see a structure that might receive innervation from the ovarian or pelvic plexus?"], "contexual_behavior": ["Does the image show a structure whose hormone production decreases as follicles are depleted, such as during menopause?", "Is there an object that may fail to release eggs due to disrupted follicular maturation, as seen in certain endocrine disorders?", "Can you identify a structure that increases estrogen secretion during the phase when follicles are developing?", "Does the image contain something that could exhibit reduced progesterone output due to inadequate corpus luteum function?", "Is there a structure that might stop ovulating under chronic stress because of altered hypothalamic-pituitary signaling?", "Can you see an object whose hormone synthesis could be altered in response to obesity and insulin resistance?", "Is there a structure that increases follicle development after fertility treatments involving ovulation induction?", "Does the image show something whose reproductive function diminishes with advancing age due to reduced reserve and follicle quality?", "Is there a structure that could show impaired function during autoimmune disorders because of immune-mediated tissue damage?", "Can you identify an object that increases androgen production in certain endocrine disorders such as congenital adrenal hyperplasia?", "Is there a structure that may fail to support early pregnancy due to inadequate progesterone production?", "Does the image contain something whose activity is suppressed during hypothalamic amenorrhea because of low gonadotropin levels?", "Is there a structure that decreases its response to gonadotropins in cases of premature failure due to early follicle loss?", "Can you see an object that might show excessive hormone output after fertility drug stimulation, as in hyperstimulation syndrome?", "Is there a structure that could have reduced function after exposure to chemotherapy or radiation due to follicular and stromal damage?", "Does the image show something that changes its hormone secretion pattern during puberty in response to gonadotropin activation?", "Is there a structure that fails to mature follicles in the context of malnutrition due to insufficient hormonal support?", "Can you identify an object that increases its metabolic activity to support follicle rupture and oocyte release during ovulation?", "Is there a structure that decreases its endocrine function in genetic conditions characterized by gonadal dysgenesis, such as Turner syndrome?", "Does the image contain something whose function is disrupted by chronic inflammation and the effects of inflammatory cytokines?"], "functions": ["Does the image show a structure involved in the production and release of eggs?", "Can you identify an organ responsible for hormone secretion that regulates the menstrual cycle?", "Is there a structure present that undergoes folliculogenesis and ovulation?", "Does the image contain an object that synthesizes estrogen and progesterone?", "Can you see a feature that coordinates follicular development and hormone secretion in response to endocrine signals?", "Is there evidence of a structure that forms a corpus luteum after ovulation?", "Does the image include an organ that supports female fertility by producing viable oocytes?", "Can you identify a structure where follicle maturation and selection of a dominant follicle occur?", "Is there a visible feature that could be associated with follicle depletion or hormonal decline, as seen in reproductive aging?", "Does the image show a structure that releases a mature oocyte in response to a luteinizing hormone surge?", "Can you see an organ that interacts with the hypothalamic-pituitary axis through hormonal feedback mechanisms?", "Is there a structure present that contributes to the maintenance of secondary sexual characteristics in females?", "Does the image contain an object that alters follicle growth and hormone secretion during the menstrual cycle?"]}, "no_questions": {"contexual_properties": ["Can you identify multiple structures with a villous shape that seem abnormally distended?", "Does the image display a region where many villi appear to be swollen or edematous?", "Does the image show finger-like projections that appear enlarged or swollen?"], "properties": ["Are there villous structures with an increased width, commonly between 0.2 and 0.5 mm?", "Is the lipid content of the villous structures consistent with normal levels, unless there is evidence of malabsorption?", "Can you identify more than 20 villous structures within a single low-power microscopic field?"], "relational": ["Does the image contain features populated by cells like enterocytes, goblet cells, or Paneth cells?", "Are there visible capillary loops, arterioles, or venules supplying any of the projections?", "Can you see lymphatic structures such as lacteals or lymphatic capillaries associated with any projections?"], "contexual_behavior": ["Are there signs that regenerative capacity is impaired, such as lack of recovery after injury due to stem cell dysfunction or chronic inflammation?", "Can you see indications of impaired electrolyte transport, such as might occur with mucosal damage or persistent diarrhea?", "Is there visual evidence of disrupted structure that could result in decreased fat absorption due to chronic inflammation or lipid transport defects?"], "functions": ["Are there visual cues of abnormal transport of nutrients or fluids across the intestinal wall?", "Is there a visible reduction in the surface area available for enzymatic activity and absorption?", "Is there evidence of impaired mucosal immune defense or increased antigen penetration in the intestinal tissue?"]}}, "uterus": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify a region that could correspond to the fundus, body, isthmus, or cervix?", "Is there an organ located adjacent to the bladder or rectum?", "Does the image contain a structure positioned near the ovaries?", "Can you see blood vessels that might be the primary supply to a reproductive organ, such as the uterine artery or vein?", "Is there evidence of supporting ligaments like the broad ligament, round ligament, or uterosacral ligament?", "Does the image show a connection between the ovaries and another structure via tubular pathways?", "Can you identify features related to the menstrual or reproductive cycles?", "Is there a visible anatomical connection between a structure and the vagina?", "Can you see tissue layers that could correspond to the endometrium, myometrium, or perimetrium?", "Does the image show tubular structures connecting to a larger organ at the uterine cornua?", "Is there an organ located within the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a structure that supports embryo implantation or fetal development?", "Is there an organ present that undergoes cyclical changes in its lining in response to hormones?", "Can you identify a tissue that sheds periodically as part of menstruation?", "Does the image contain a structure that provides a protective environment for fetal growth?", "Is there evidence of an organ that expands during pregnancy to accommodate a growing fetus?", "Can you see a structure that supports placental attachment and maternal-fetal exchange?", "Is there an object that generates coordinated muscular contractions to facilitate childbirth?", "Does the image show a tissue that responds to hormones such as estrogen or progesterone?", "Is there a structure that produces secretory factors to facilitate embryo implantation?", "Can you identify an organ that forms a physical barrier and provides immunological protection for a developing fetus?", "Does the image contain a structure responsible for expelling menstrual blood and tissue?", "Is there evidence of rhythmic contractions under the influence of oxytocin to aid in delivery?", "Can you see a tissue that supplies nutrients and removes waste for fetal development?", "Is there an organ whose structural and functional changes are regulated by reproductive hormones?", "Does the image show a structure essential for fertility, pregnancy support, or menstrual health?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?"], "contexual_behavior": [], "functions": ["Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?"]}}, "edema": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region where tissue appears swollen due to increased fluid volume?", "Can you identify an area that might contain fluid with a clear or pale yellow appearance?", "Is there evidence of swelling in a dependent area, such as the lower limbs or sacral region?", "Does the image suggest the presence of tissue with increased water content, possibly exceeding 80% of its weight?", "Can you see a region where the fluid accumulation could range from several hundred milliliters to several liters?", "Is there an area that might contain fluid with a composition similar to plasma, including water, electrolytes, and protein?", "Does the image show swelling that could be due to fluid with a sodium concentration similar to plasma (approximately 135\u2013145 mmol/L)?", "Can you identify a region where the fluid might have a protein content consistent with either transudate (less than 3 g/dL) or exudate (greater than 3 g/dL)?", "Is there evidence of swelling where the fluid could have a specific gravity less than 1.015 or greater than 1.015, suggesting transudate or exudate?", "Does the image suggest the presence of fluid with a neutral to slightly alkaline pH, around 7.4?", "Can you see an area where the fluid's osmolarity might be similar to plasma, about 275\u2013295 mOsm/kg?", "Is there swelling in a region where the chloride concentration of the fluid could be close to plasma levels (around 98\u2013106 mmol/L)?", "Does the image show tissue that might contain fluid with a glucose concentration similar to plasma (approximately 70\u2013100 mg/dL)?", "Can you identify an area where the temperature of the accumulated fluid would likely reflect body temperature (36\u201337\u00b0C)?", "Is there a region where the clarity of the fluid could help distinguish between transudate (clear, non-turbid) and exudate (cloudy)?", "Does the image suggest a rate of fluid accumulation that could vary from several milliliters to liters per day depending on the underlying cause?"], "relational": ["Does the image show abnormal fluid accumulation in subcutaneous tissue or mucous membranes?", "Can you identify swelling in regions such as the lower limbs, ankles, or periorbital area?", "Is there evidence of fluid buildup in interstitial tissue or body compartments like the pleural or peritoneal cavity?", "Does the image display changes in organs such as the lungs, brain, liver, or kidneys that could indicate structural impact from excess fluid?", "Can you see signs of impaired lymphatic drainage, such as distended lymphatic vessels or lymph nodes?", "Is there visible swelling that could be related to lymphatic vessel dysfunction or obstruction?", "Does the image reveal features of the cardiovascular, renal, or lymphatic systems that might be involved in abnormal fluid retention?", "Are there indications of fluid accumulation in loose connective tissue or areolar tissue?", "Can you observe any alterations in capillaries, venules, or veins that might contribute to fluid leakage?", "Is there evidence of disruption to anatomical barriers like capillary endothelium or basement membrane that could affect fluid movement?"], "contexual_behavior": [], "functions": ["Does the image show evidence of tissue swelling that could indicate increased interstitial pressure?", "Can you identify an area where excess accumulation of interstitial fluid might be present?", "Is there a region where tissue fluid balance appears disrupted, possibly due to reduced fluid reabsorption?", "Does the image display localized swelling that could be associated with increased vascular permeability?", "Can you see signs of impaired organ function that might result from altered tissue architecture or increased pressure?", "Is there visual evidence suggesting that nutrient or oxygen delivery to tissues could be compromised, such as compressed capillaries or increased diffusion distance?", "Does the image show features that might indicate overloading or obstruction of lymphatic vessels, suggesting hindered lymphatic drainage?", "Can you identify areas where wound healing appears delayed, possibly due to increased infection risk or disrupted tissue repair?", "Is there a region where cellular signaling could be altered, such as changes in tissue structure that might affect cytokine gradients?", "Does the image reveal signs of chronic inflammation or tissue damage that could facilitate fibrosis?", "Can you see indications that metabolic waste removal from tissues might be impaired, such as slowed interstitial fluid flow or compromised venous and lymphatic clearance?"]}, "no_questions": {"contexual_properties": ["Are there cells whose staining properties differ from surrounding cells, indicating changes in cytoplasmic or nuclear composition?", "Are there cells with altered membrane appearance, such as irregular or disrupted cell borders, possibly due to swelling or viral effects?", "Does the image show cells that appear enlarged compared to their neighbors, suggesting a pathological process?"], "properties": ["Do any nuclei exhibit chromatin that is marginated or clumped, possibly with a clear 'halo' around inclusions?", "Can you identify any cells with diameters in the range of 20 to 40 micrometers or greater?", "Is there evidence of cells with volumes surpassing 4000 cubic micrometers?"], "relational": ["Can you identify any cells, such as epithelial or endothelial cells, that appear larger than normal?", "Is there evidence of pathological processes like viral infection, inflammation, or neoplasia that could be associated with enlarged cells?", "Can you observe alterations in the cellular membrane that might indicate abnormal cell growth?"], "contexual_behavior": [], "functions": ["Is there evidence of disrupted tissue architecture or impaired intercellular communication?", "Are there indications of disrupted signal transduction or altered receptor function in the cells present?", "Can you observe features that might indicate altered energy utilization or changes in biosynthetic activity at the cellular level?"]}}, "tube adherent to the adjacent ovary on the other side": {"yes_questions": {"contexual_properties": ["Is there a tubular structure adjacent to an ovary that appears thickened, suggesting chronic inflammation or a history of pelvic inflammatory disease?", "Can you identify a tube near the ovary that looks swollen, which might indicate acute infection or an ectopic pregnancy?", "Does the image show a tube next to the ovary with color changes that could be due to hemorrhage, ischemia, or necrosis?", "Is there evidence of fibrous tissue formation in a tube adherent to the ovary, possibly resulting from chronic inflammation and healing?", "Can you see a rigid tubular structure near the ovary, which may be due to extensive fibrosis or calcification from repeated inflammation?", "Is there increased vascularity in a tube adjacent to the ovary, suggesting acute inflammation or a neoplastic process?", "Does the tube near the ovary appear edematous, which could be a response to acute infection or an allergic reaction?", "Can you observe cystic changes in a tube adherent to the ovary, as seen in hydrosalpinx or chronic salpingitis?", "Is there evidence of calcification in a tube next to the ovary, possibly following chronic inflammation or previous tubal infections?", "Does the image show signs of inflammation in a tube adjacent to the ovary, as might occur during pelvic inflammatory disease or infection?", "Is there abnormal tissue growth in a tube near the ovary, which could be due to endometriosis or neoplastic transformation?", "Can you identify a shortened tubular structure adherent to the ovary, possibly resulting from scarring and fibrosis after repeated inflammation?", "Does the tube next to the ovary appear to have lost its normal structure, which may be due to chronic infection, adhesions, or tissue destruction?", "Is there evidence of adhesions involving a tube and the adjacent ovary, possibly following pelvic inflammatory disease, surgery, or endometriosis?", "Can you see a distended tube near the ovary, which might indicate hydrosalpinx or tubal obstruction?"], "properties": ["Is there an elongated, tubular structure adjacent to an ovary on the opposite side in the image?", "Can you identify a soft and pliable structure with a pale pink color near an ovary?", "Does the image show a structure with a length of approximately 10 to 12 centimeters and a diameter of 1 to 4 millimeters?", "Is there a visible object with a wall thickness of about 1 millimeter?", "Can you see a structure whose average weight would be around 5 to 10 grams?", "Is there an object with a volume estimated between 0.5 and 1 milliliter?", "Does the image include a structure with moderate vascularity and a rich capillary network?", "Can you identify a structure that would contain ciliated epithelial cells, secretory cells, smooth muscle cells, and stromal cells?", "Is there a structure lined by simple columnar epithelium with both ciliated and secretory cells?", "Can you see an object with high water content, approximately 70% by weight?", "Is there a structure with moderate collagen content, especially in the lamina propria and muscularis layers?", "Does the image show a structure with considerable elasticity, allowing for distension and contraction?", "Can you identify an object whose tissue pH would be near neutral, around 7.2 to 7.4?", "Is there a structure with a density similar to soft tissue, about 1.05 grams per cubic centimeter?", "Does the image include a structure that would be at a temperature of approximately 37 degrees Celsius?", "Can you see an object whose extracellular matrix is composed of collagen, elastin, glycosaminoglycans, and proteoglycans?", "Is there a structure where fibrosis appears minimal under normal conditions?", "Does the image show a structure with no visible signs of inflammation under normal circumstances?"], "relational": ["Does the image show a structure that is part of the female reproductive system and appears physically attached to an adjacent ovary?", "Can you identify a tube-like structure in the pelvic region that is in direct contact with an ovary on the opposite side?", "Is there evidence of adhesion or physical attachment between a tubular structure and an ovary?", "Does the image contain a structure that is supported by tissues such as the mesosalpinx or serosal layers?", "Can you see a tube that is anatomically connected to both the ovary and the uterus?", "Is there a structure in the reproductive tract that communicates with the uterus at the uterine horn?", "Does the image show a tube composed of segments such as the infundibulum, ampulla, isthmus, or interstitial part?", "Can you identify a structure that receives blood supply from the ovarian or uterine arteries?", "Is there a tube-like structure associated with ligaments such as the broad ligament or the suspensory ligament of the ovary?", "Does the image show a structure located near the ovary, uterus, urinary bladder, or rectum within the pelvic region?"], "contexual_behavior": ["Does the image show a structure whose continuity or movement is disrupted by pelvic adhesions or scarring, potentially impairing gamete transport?", "Is there evidence of a tube-like structure with narrowed or blocked lumen, suggesting possible impairment of fertilization due to inflammation or fibrosis?", "Can you identify a structure where ciliary movement might be altered, possibly as a result of pelvic inflammatory disease affecting the ciliated epithelium?", "Does the image contain a tubular structure that appears unable to clear debris or pathogens effectively, indicating chronic infection or impaired mucociliary clearance?", "Is there a structure present that, if its patency or function is compromised, could increase the risk of ectopic implantation due to embryo retention?", "Can you see a tube whose fimbrial end appears restricted or adherent, potentially reducing its ability to pick up oocytes after ovulation?", "Does the image show a tubular structure with signs of impaired peristaltic activity, possibly due to infection affecting smooth muscle contractility?", "Is there visual evidence of anatomical distortion or fibrosis in a tube-like structure, suggesting dysfunction possibly related to endometriosis?", "Can you identify a structure whose secretory activity might be altered in response to hormonal changes, affecting epithelial cell function?", "Does the image show a tube that may fail to support embryo transport due to mechanical obstruction or loss of coordinated motility from pelvic adhesions?"], "functions": ["Is there a structure visible that appears to be attached to an adjacent ovary, potentially affecting the capture and transport of an egg toward the uterus?", "Can you identify a conduit near the ovary whose adherence might impede the normal passage of gametes?", "Does the image show a location where sperm and egg could meet, but where adhesion might disrupt this process?", "Is there evidence of impaired ciliary motion or reduced motility in a tube adjacent to the ovary due to adherence?", "Can you see any indication of mechanical obstruction or altered function in a tube that could lead to infertility?", "Is there a structure whose adherence to the ovary could hinder the passage of an embryo toward the uterus, suggesting a risk of tubal obstruction?", "Does the image suggest disruption of the environment needed for fertilization, such as altered fluid secretion or microenvironment regulation, due to tube-ovary adhesion?", "Can you observe restricted movement of fimbriae or impaired access to the ovary, possibly interfering with ovum capture?", "Is there a visible abnormal attachment that could increase the risk of ectopic pregnancy by promoting implantation within the tube?", "Does the image show a tube whose adherence to the ovary might impair the clearance of peritoneal fluid by restricting normal drainage or mobility?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify cells with an estimated lifespan of several months?", "Do you see cells with a density close to 1.05 grams per cubic centimeter?", "Are there cells that might express surface markers such as CK19, EpCAM, or MUC1?"], "relational": ["Does the image show cellular components of the digestive or hepatic system?", "Can you identify cells located within the liver?", "Can you see anatomical connections to features like the Canals of Hering or portal triads?"], "contexual_behavior": [], "functions": ["Does the image show features that could be associated with water transport or pH regulation in bile?", "Does the image display features consistent with secretion or absorption processes that regulate bile volume or composition?", "Can you see any indication of paracrine signaling or immune modulation between cells in the liver region?"]}}, "adjacent ovary": {"yes_questions": {"contexual_properties": ["Is there a structure that appears enlarged, which could suggest hyperstimulation, neoplasm, or inflammation?", "Can you identify an object that seems shrunken, possibly due to menopause, atrophy, or surgical removal?", "Does the image show a structure with abnormal color, which might indicate hemorrhage, ischemia, or necrosis?", "Is there evidence of cystic formations that could be related to ovulatory dysfunction, polycystic ovary syndrome, or benign cystic disease?", "Can you see a structure that appears edematous, suggesting torsion, inflammation, or vascular congestion?", "Is there an area with visibly increased vascularity, which may be associated with ovulation, neoplastic growth, or inflammation?", "Does the image reveal fibrotic changes that could result from chronic inflammation, aging, or endometriosis?", "Is there an object with altered texture, possibly due to tumor, fibrosis, or cystic changes?", "Can you observe fluid accumulation that might be caused by cyst formation, edema, or ascites?", "Is there evidence of calcification, which could be linked to aging, previous inflammation, or certain tumors?", "Does the image show a structure that appears atrophic, potentially due to menopause, radiation, or chronic disease?", "Can you identify abnormal tissue that may be present in neoplastic processes, endometriosis, or dysplasia?", "Is there a structure that seems to have increased weight, possibly from tumor growth, cyst formation, or edema?", "Does the image show decreased volume of a structure, which could follow atrophy, menopause, or surgical intervention?", "Is there evidence of hemorrhage, such as after trauma, torsion, or a ruptured cyst?", "Can you see signs of altered hormone activity, which might be associated with endocrine disorders, tumors, or polycystic ovary syndrome?", "Is there a surface irregularity visible, possibly due to scarring, endometriosis, or neoplastic invasion?", "Does the image reveal changes in follicle count, which could occur during puberty, menopause, or in polycystic ovary syndrome?", "Can you observe signs of inflammation, such as might be seen in pelvic inflammatory disease, infection, or autoimmune conditions?", "Is there evidence of necrosis, potentially resulting from prolonged torsion, severe ischemia, or infarction?"], "properties": ["Is there a structure present that measures between 3 to 5 centimeters in length and 1.5 to 3 centimeters in width?", "Can you identify an object with an oval or almond-like shape?", "Does the image show a structure with a pale whitish or grayish-pink appearance?", "Is there a region that appears firm and slightly nodular, possibly due to developing follicles?", "Can you see an area with a high density of blood vessels supporting follicular development?", "Is there a structure whose estimated volume is between 6 and 10 cubic centimeters?", "Does the image contain a region that could contain oocytes, granulosa cells, or theca cells?", "Can you identify a structure that might have hundreds to thousands of follicles in reproductive-age individuals?", "Is there an object likely to have physiologically relevant levels of estradiol, progesterone, or inhibin?", "Does the image show a structure with significant connective tissue, such as a tunica albuginea or stroma?", "Can you see a region with moderate lipid content, mainly cholesterol and phospholipids?", "Is there a structure whose density could be approximately 1.05 grams per cubic centimeter?", "Does the image contain an area with a surface area of about 6 to 10 square centimeters?", "Can you identify a structure that would be close to core body temperature, around 37 degrees Celsius?", "Is there a region likely to have a water content of 70 to 80 percent by weight?", "Does the image show a structure with slightly alkaline pH, around 7.2 to 7.4?", "Can you see an object that contains structural proteins, enzymes, and hormone-binding proteins?", "Is there a region with mineral content such as calcium, magnesium, or trace elements?", "Does the image show a structure weighing approximately 5 to 8 grams in adult females?"], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify an organ located near both the uterus and the fallopian tube?", "Is there a structure positioned adjacent to the urinary bladder?", "Does the image contain a structure connected by the ovarian ligament or the suspensory ligament of the ovary?", "Can you see a region that appears to receive blood supply from the ovarian artery or branches of the uterine artery?", "Is there an anatomical structure adjacent to the fallopian tube, broad ligament, or pelvic wall?", "Can you identify tissue surrounded by peritoneum, connective tissue, or mesovarium?", "Does the image show a structure closely related to the fimbriae of the fallopian tube, possibly involved in oocyte capture during ovulation?", "Is there a structure located in the ovarian fossa of the lateral pelvic region?", "Can you see an object anchored within the pelvic cavity by ligaments such as the ovarian ligament, suspensory ligament, or mesovarium?", "Does the image include an organ that interacts anatomically with the uterus, fallopian tube, or rectum?"], "contexual_behavior": ["Does the image show a structure that may reduce hormone production when disease affects its counterpart, potentially disrupting endocrine feedback?", "Is there evidence of increased follicular activity in a structure that could compensate for the removal of ovarian tissue on the opposite side?", "Can you identify a structure that might enhance its ovulatory function to compensate for impaired ovulation elsewhere?", "Does the image contain a structure whose endocrine function could be altered by pelvic inflammation or inflammatory mediators?", "Is there a structure that may show decreased responsiveness to gonadotropins following exposure to radiation, possibly due to follicular or stromal damage?", "Can you see a structure that might increase estrogen synthesis to maintain hormonal balance after the loss of its contralateral counterpart?", "Does the image include a structure that could exhibit impaired oocyte maturation during systemic illness or metabolic stress?", "Is there a structure that may have altered vascular supply as a result of surgical intervention on the opposite side?", "Can you identify a structure whose reproductive capacity might be reduced due to chemotherapy-induced follicular depletion or stromal damage?", "Does the image show a structure that could increase its ovulatory frequency in response to polycystic changes in its counterpart, reflecting compensatory folliculogenesis?"], "functions": ["Does the image show a structure involved in oocyte maturation or follicle development?", "Is there an object present that produces hormones such as estrogen or progesterone?", "Can you identify a structure that supports the progression of oocytes to maturity?", "Does the image contain something responsible for regulating the menstrual cycle through hormone release?", "Is there a visible feature associated with the release of mature oocytes during ovulation?", "Can you see a structure that coordinates hormone production and gamete release to prepare the reproductive tract?", "Is there evidence of follicle growth or maturation under hormonal control in the image?", "Does the image show an object interacting with the fallopian tube or ovarian stroma to support reproductive processes?", "Can you identify a structure that maintains hormonal balance by modulating estrogen and progesterone secretion?", "Is there an object that responds to signals from the hypothalamus or pituitary gland, adjusting its activity according to gonadotropin levels?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see any displacement or compression of the cerebellum?", "Is there a lesion situated in anatomical compartments such as the cerebellopontine angle or tentorial region?", "Does the image reveal a mass near major blood vessels like the vertebral arteries or basilar artery?"], "contexual_behavior": [], "functions": ["Are there indications of brainstem compression that could lead to altered consciousness or autonomic dysfunction?", "Can you identify signs of cerebrospinal fluid pathway obstruction, such as ventricular enlargement or hydrocephalus?", "Does the image show features suggestive of impaired coordination or ataxia due to disruption of cerebellar pathways?"]}}, "adherent": {"yes_questions": {"contexual_properties": ["Is there a surface in the image that appears thicker due to accumulation of material or increased cellularity?", "Can you identify a layer that looks denser, possibly from compact substance deposition or dehydration?", "Does the image show a material whose color suggests chemical reaction, oxidation, or the presence of pigments or blood?", "Is there a deposit that appears more extensive, possibly indicating progression of an underlying pathological process?", "Can you see a substance that seems difficult to remove, perhaps due to hardening or increased adhesion?", "Does any film or layer look irregular, which could be a result of uneven deposition, erosion, or localized damage?", "Is there a plaque-like structure that has increased in size, potentially from ongoing bacterial or lipid accumulation?", "Can you observe a coating whose hardness or softness might be explained by changes in hydration, mineralization, or chemical composition?", "Is there a mass that appears to have a mixed composition, possibly due to incorporation of new substances or metabolic or inflammatory changes?", "Does the image show a residue that seems to have accumulated rapidly, perhaps because production exceeds clearance or environmental conditions favor deposition?", "Is there a structure that looks friable, which could be due to degeneration, inflammation, or enzymatic breakdown?", "Can you identify a layer that is less transparent, possibly from thickening, pigment accumulation, or cellular infiltration?", "Does any deposit appear calcified, suggesting calcium salt deposition from dystrophic or metastatic processes?", "Is there a material that looks more permeable, perhaps due to structural disruption, inflammation, or enzymatic activity?", "Can you see a surface with cracks or fissures, which might result from mechanical stress, dehydration, or changes in the underlying tissue?"], "properties": ["Does the image show a cell with a flattened or spread-out appearance on a surface?", "Can you identify a cell with a polygonal shape attached to a substrate?", "Is there a cell present that appears translucent or has a pale cytoplasm under the microscope?", "Can you see a cell whose diameter is likely between 10 and 30 micrometers?", "Does the image contain a cell with a surface area estimated between 500 and 3000 square micrometers?", "Is there evidence of a cell containing visible organelles such as mitochondria, endoplasmic reticulum, or Golgi apparatus?", "Can you identify a cell that might contain hundreds to thousands of organelles?", "Does the image show a cell that could have between 100 and 2000 mitochondria?", "Is there a cell present that likely contains cytoskeletal elements such as actin?", "Can you see a cell that may express proteins like integrins, cadherins, or focal adhesion kinases?", "Is there a cell that appears to be attached to a substrate with significant adhesion strength?", "Does the image show a cell whose water content could be around 70% of its mass?", "Can you identify a cell with a lipid content estimated at 5 to 10% of its total mass?", "Is there a cell present that might have a cytoplasmic pH close to 7.2?", "Can you see a cell whose density is likely near 1.05 grams per cubic centimeter?", "Does the image contain a cell that could double in population every 18 to 36 hours under optimal conditions?"], "relational": ["Does the image show abnormal fibrous bands connecting anatomical structures that are usually separate?", "Can you identify scar tissue forming a pathological connection between organs?", "Is there evidence of restricted movement of organs due to abnormal tissue bridges?", "Does the image contain fibrous structures in regions such as the abdominal, pelvic, or thoracic cavity?", "Can you see tissue that appears to fix organs in place abnormally?", "Is there a structure composed of cells like fibroblasts or collagen-producing cells forming connections between organs?", "Does the image show abnormal tissue involving the peritoneum, pleura, or other serosal surfaces?", "Are there visible connections between the intestines and the abdominal wall or omentum?", "Can you identify abnormal boundaries or fibrous bridges joining adjacent organs or compartments?", "Is there evidence of serosal surfaces being bridged by continuous fibrous tissue?", "Does the image show abnormal tissue affecting the digestive, reproductive, or respiratory systems?", "Are there pathological connections involving the small intestine, colon, uterus, or liver visible in the image?"], "contexual_behavior": ["Does the image show cells at a wound site during the proliferative phase of tissue repair, where increased attachment and migration are expected?", "Can you identify areas where cells appear to have lost adhesion, as might occur during metastasis or cancer progression?", "Is there evidence of disrupted cell attachment that could be associated with inflammation or cytokine activity?", "Do you observe changes in cell attachment that might be linked to low oxygen levels or hypoxia?", "Are there regions where cell-cell or cell-matrix interactions seem impaired, suggesting the presence of infection or pathogen disruption?", "Does the image show fibroblasts with enhanced attachment to the extracellular matrix, as seen in fibrotic conditions?", "Can you detect areas where cell adhesion appears reduced, possibly due to exposure to toxins or membrane damage?", "Is there visual evidence of altered cell attachment that could be explained by autoimmune disease targeting adhesion proteins?", "Do you see regions where changes in the extracellular matrix might promote integrin-mediated cell attachment?", "Are there cells that appear to have lost adhesion and gained migratory properties, as would be expected during epithelial-mesenchymal transition?", "Can you identify restoration of normal cell attachment that might result from anti-inflammatory treatment?", "Is there evidence of impaired cell adhesion that could be due to genetic disorders affecting adhesion proteins?", "Do you observe cells modulating their attachment as part of the wound healing and re-epithelialization process?", "Are there signs of reduced cell adhesion that could be attributed to oxidative stress or damage from reactive oxygen species?", "Does the image show increased cell attachment that might be stimulated by growth factors upregulating adhesion molecules?"], "functions": ["Is there evidence of cells forming stable attachments that maintain tissue architecture and cohesion?", "Can you identify structures where cells are anchored to the extracellular matrix, supporting tissue organization?", "Does the image show intercellular junctions or complexes that might mediate cell signaling?", "Are there visible features suggesting cell migration or tissue repair, such as cells moving toward an injury site?", "Can you see strong intercellular connections or matrix attachments that contribute to tissue stability?", "Is there evidence of dynamic adhesion between cells and the extracellular matrix, indicating cell motility or migration?", "Does the image reveal the presence of integrins or other adhesion receptors mediating matrix interaction?", "Are there signs of cells guiding tissue development, such as organized positioning or differentiation patterns?", "Can you observe organized tissue architecture that supports specialized cellular activities or organ function?", "Is there a visible barrier formed by tight or adherens junctions controlling tissue permeability?"]}, "no_questions": {"contexual_properties": ["Does the image show increased stromal content or signs of a desmoplastic reaction in the tumor microenvironment?", "Can you see calcifications within a lesion, which may develop during chronic tumor evolution or after necrosis?", "Is there a structure that appears more invasive, suggesting acquisition of features promoting invasion or metastasis?"], "properties": ["Is there positivity for basal cytokeratins, such as CK5/6 or CK14, in the tumor cells?", "Are there extensive areas of necrosis, possibly central, within the tumor tissue?", "Is there evidence of high chromosomal or genomic instability in the neoplastic cells?"], "relational": ["Is there evidence of carcinoma in a structure associated with the breast?", "Does the specimen appear to be from a core needle biopsy or surgical excision of breast tissue?", "Is there a tissue sample where estrogen receptor and HER2 expression appear absent?"], "contexual_behavior": [], "functions": ["Is there evidence suggesting resistance to hormone therapies such as tamoxifen or trastuzumab?", "Are there visual cues indicating increased aggressiveness or a likelihood of early relapse in the tumor?", "Are there signs of deregulated cell proliferation, possibly due to loss of hormonal regulation?"]}}, "hemorrhagic inflammatory mass": {"yes_questions": {"contexual_properties": ["Is there a mass in the image that appears larger, possibly due to ongoing inflammation or accumulation of fluid?", "Can you identify a structure that seems to have increased in size, suggesting active bleeding or exudate accumulation?", "Does the image show a mass that appears to be shrinking, which could indicate resolution of inflammation or successful treatment?", "Is there evidence of a structure becoming more edematous, possibly due to increased vascular permeability?", "Can you observe a mass with color changes that might reflect blood degradation or different stages of inflammation and healing?", "Does the image show a mass that appears firmer, suggesting fibrosis or organization of exudate?", "Is there a region that looks softer, possibly due to tissue breakdown or pus formation?", "Can you see a mass with signs of recent or ongoing bleeding, such as increased redness or evidence of vessel rupture?", "Is there an area that appears necrotic, which could result from compromised blood supply or severe inflammation?", "Does the image reveal a mass with pus accumulation, indicating possible secondary bacterial infection?", "Can you identify a structure that appears encapsulated, suggesting chronic inflammation and fibrous tissue formation?", "Is there evidence of increased vascularity in a mass, possibly due to active inflammation or new blood vessel formation?", "Does the image show a mass with reduced blood content, which might be due to reabsorption or drainage?", "Can you observe changes in the cellular makeup of a mass, such as increased immune cell infiltration or signs of healing?", "Is there a structure that appears more infiltrated by immune cells, indicating an acute or chronic inflammatory response?", "Does the image show evidence of calcification within a mass, possibly due to chronic inflammation or mineralization of necrotic tissue?", "Can you identify a mass that looks more friable, which could be a result of ongoing tissue necrosis?", "Is there a region with increased tissue breakdown, possibly due to severe inflammation or infection?", "Does the texture of a mass appear altered, such as being more edematous, necrotic, fibrotic, or calcified?", "Can you see evidence of fibrotic tissue developing within a mass, suggesting healing or chronic inflammation?", "Is there a mass that appears heavier or denser, possibly due to accumulation of blood, exudate, or cellular infiltrate?"], "properties": ["Is there a structure in the image that appears irregular or nodular in shape?", "Can you identify an area with a red to dark red coloration, possibly mixed with yellow or brown tones?", "Does the image show a mass whose size could range from a few millimeters to several centimeters?", "Is there an object that appears soft, firm, friable, or gelatinous in consistency?", "Can you see a region that might have a high proportion of blood content, potentially exceeding 30% of its volume?", "Is there a mass that could contain both blood and inflammatory cells such as neutrophils, macrophages, or lymphocytes?", "Does the image include a structure that might have elevated fibrin content due to coagulation and inflammation?", "Can you identify an area that may have increased levels of inflammatory mediators like cytokines or chemokines?", "Is there a mass whose density appears similar to or slightly higher than that of surrounding soft tissue?", "Does the image show a structure that could have a high water content, possibly between 60% and 80%?", "Is there an object that might contain necrotic tissue and extracellular matrix components?", "Can you see a mass that could have an increased protein concentration due to plasma proteins and cellular debris?", "Is there a region that might be at or near core body temperature, around 37\u00b0C?", "Does the image show a structure whose weight could vary from less than a gram to several grams, proportional to its size?", "Is there an area that could be slightly acidic, with a pH between 6.5 and 7.0?"], "relational": ["Does the image show a lesion that appears to originate from connective, epithelial, or vascular tissue?", "Is there an abnormal mass present in regions such as the lungs, brain, gastrointestinal tract, or skin?", "Can you identify an area containing a mix of cells like neutrophils, macrophages, erythrocytes, or lymphocytes?", "Does the image display a mass associated with small blood vessels such as capillaries, arterioles, or venules?", "Is there a structure within organs like the liver, lung, brain, or kidney that appears abnormal?", "Can you see a mass surrounded by a fibrous capsule or adjacent to parenchymal tissue?", "Is there evidence of tissue disruption, edema, or necrosis near an abnormal mass?", "Does the image suggest involvement of the circulatory, immune, or nervous system due to a localized lesion?", "Can you identify a mass that contains blood, inflammatory cells, fibrin, or necrotic tissue?", "Is there a visible anatomical barrier, such as a basement membrane, fascia, or organ capsule, containing or limiting the spread of a mass?"], "contexual_behavior": ["Is there a region in the image that appears to have increased bleeding, possibly indicating acute vascular injury or impaired coagulation?", "Can you identify an area where swelling and accumulation of inflammatory cells might be impairing local tissue function?", "Does the image show a mass with reduced inflammatory cell infiltration, which could suggest the resolution phase of inflammation or the effects of immunosuppression?", "Is there evidence of a lesion that appears unresolved, potentially due to persistent infection or chronic inflammatory activity?", "Can you see a structure that might be promoting abnormal clot formation, possibly related to excessive tissue factor release or a hypercoagulable state?", "Is there a region where vascular permeability seems decreased, which could indicate late-stage healing or the effects of anti-inflammatory therapy?", "Does the image reveal an area with pronounced tissue destruction, possibly associated with intensified inflammation in autoimmune conditions?", "Is there a mass that appears to be healing slowly, which could be due to impaired immune cell function or delayed tissue repair in an immunocompromised individual?", "Can you identify a region with heightened pro-inflammatory signaling, such as increased cellularity or edema, that might be associated with acute injury and cytokine surge?", "Does the image show a lesion with reduced hemorrhagic activity, possibly as a result of anti-inflammatory therapy and vascular stabilization?", "Is there a structure where swelling or vascular congestion appears to be restricting blood flow and impairing nutrient delivery to surrounding tissues?", "Can you see evidence of altered clot formation or increased bleeding risk in a region that might be influenced by anticoagulant therapy?", "Is there an area with increased edema, possibly related to an allergic reaction and histamine release enhancing vascular permeability?", "Does the image display a mass with a diminished inflammatory response, which could be due to chronic disease or immune exhaustion?", "Is there a region where local immune defenses appear overwhelmed, potentially allowing for the spread of pathogens in the context of severe infection?"], "functions": ["Is there a structure in the image that appears to localize injury and contain bleeding at a specific site?", "Can you identify an area that might be amplifying the inflammatory response by serving as a site for immune cell accumulation?", "Does the image show a region that could act as a scaffold for granulation tissue formation or the initiation of healing processes?", "Is there evidence of disrupted local blood flow, such as vascular congestion, edema, or the presence of extravasated blood?", "Can you see a mass that might facilitate immune cell recruitment by increasing vascular permeability or releasing chemotactic factors?", "Is there a visible area where clot formation, platelet aggregation, or fibrin deposition could be promoting hemostasis?", "Does the image contain a mass that could be compressing surrounding tissues or causing hypoxia and functional impairment?", "Can you identify a region that may be aiding in pathogen or debris removal by attracting phagocytic cells such as neutrophils or macrophages?", "Is there a structure that appears to sustain cellular infiltration and prolong mediator release, suggesting ongoing or chronic inflammation?", "Does the image show an area where inflammatory mediator release might be regulated by activated immune cells, such as through cytokine or chemokine production?"]}, "no_questions": {"contexual_properties": ["Do any structures appear unusually pale, potentially indicating anemia or acute blood loss?", "Is there evidence of altered bone density, such as thinning or thickening, which could be due to osteoporosis or osteomyelitis?", "Do any areas appear to lack sensation, as might occur in peripheral neuropathy or nerve compression?"], "properties": [], "relational": ["Does the image show structures that are part of both the musculoskeletal and integumentary systems?", "Can you identify components that are formed by phalanges?", "Can you identify elements located within the anatomical regions of the hand or foot?"], "contexual_behavior": [], "functions": ["Can you see a structure that allows for probing, touching, or interacting with the environment to gather sensory input?", "Is there a structure in the image that enables grasping or manipulation of objects?", "Is there a structure used for gesturing, forming signs, or nonverbal communication?"]}}, "kidney": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears enlarged, which could be associated with conditions like hydronephrosis or acute inflammation?", "Can you identify an organ that seems shrunken, possibly indicating chronic disease or prolonged atrophy?", "Does the image show a structure with altered coloration, such as areas of pallor or hemorrhage, which might suggest infarction or infection?", "Is there evidence of multiple cystic spaces within an organ, as seen in disorders like polycystic disease?", "Can you observe a structure with increased fatty tissue, which could be related to obesity or lipomatosis?", "Does the image reveal areas of scarring or irregular surface texture that might result from chronic inflammation or hypertension?", "Is there a structure that appears fibrotic, possibly due to repeated injury or chronic disease?", "Can you see an organ that seems heavier or more swollen than usual, which could be due to inflammation, congestion, or tumor growth?", "Is there evidence of reduced organ mass, as might occur in chronic atrophic processes or end-stage disease?", "Does the image show abnormal tissue formations, such as masses, cysts, or granulomas?", "Can you identify calcifications within a structure, which may be associated with chronic infection or metabolic disorders?", "Is there a visible accumulation of fluid within or around an organ, suggesting hydronephrosis or acute inflammation?", "Does the image show an organ with a pale appearance, which could indicate anemia, shock, or ischemia?", "Can you observe hemorrhagic areas within a structure, possibly resulting from trauma or vasculitis?", "Is there evidence of stones or mineral deposits within a tubular or bean-shaped organ, as seen in nephrolithiasis?", "Does the image reveal textural changes such as fibrosis, scarring, or cystic transformation?", "Can you identify features that might indicate impaired filtration, such as swelling or abnormal tissue, which could correlate with increased creatinine levels?", "Is there a structure that appears swollen, possibly due to obstruction, edema, or acute inflammation?", "Does the image show signs of abnormal protein accumulation, such as frothy urine or swelling, which might be linked to proteinuric conditions?", "Can you observe any features suggesting decreased filtration rate, such as reduced size or abnormal texture, which could be related to glomerular diseases or advanced failure?"], "properties": ["Is there a bean-shaped structure with a convex lateral border and a concave medial border visible in the image?", "Can you identify an organ that typically measures about 10 to 12 centimeters in length and 5 to 7 centimeters in width?", "Does the image show a reddish-brown structure, suggesting a rich blood supply?", "Is there an object whose estimated volume could be between 110 and 190 milliliters?", "Can you see a structure that might weigh between 120 and 170 grams in adults?", "Is there a region in the image that appears firm and smooth on the surface?", "Does the image contain an organ likely to have a density close to 1.05 grams per cubic centimeter?", "Can you identify a structure that is expected to contain specialized cells such as podocytes or tubular epithelial cells?", "Is there an object present that would be composed of approximately 80% water by weight?", "Can you see a structure that would have a low fat content, generally less than 2% of its wet weight?", "Is there an organ that might have a protein composition of about 15 to 18% of its wet weight?", "Does the image show a structure whose tissue pH would be slightly acidic to neutral, around 7.2 to 7.4?", "Can you identify an object that could have a sodium concentration of 40 to 70 millimoles per kilogram wet weight?", "Is there a structure present with a potassium concentration of about 70 to 100 millimoles per kilogram wet weight?", "Does the image contain an organ with a calcium concentration of 1 to 2 millimoles per kilogram wet weight?", "Can you see a region that would have an oxygen level of approximately 40 to 50 mmHg in its cortex?", "Is there a structure that would typically have a low glucose level, around 1 to 2 millimoles per liter?", "Can you identify an object with a creatinine concentration of about 0.1 to 0.2 millimoles per kilogram wet weight?", "Is there an organ present that would have a urea concentration of approximately 2 to 6 millimoles per kilogram wet weight?", "Does the image show a structure that could contain between 800,000 and 1.5 million nephrons?"], "relational": ["Does the image show a structure that is part of the urinary system?", "Can you identify an organ located in the retroperitoneal space of the posterior abdomen?", "Is there a structure connected to a duct responsible for transporting urine to the bladder?", "Does the image contain an organ that receives blood supply from a vessel known as the renal artery?", "Can you see a structure with distinct regions such as a cortex and medulla?", "Is there an object featuring internal parts like the renal pelvis or calyces?", "Does the image show a tissue that could contain specialized cells such as podocytes or mesangial cells?", "Is there a structure situated near the adrenal gland, spleen, or liver?", "Can you identify an organ that is positioned inferior to the adrenal gland and separated from it by connective tissue?", "Does the image include a vessel or duct that could be a ureter?"], "contexual_behavior": ["Is there a structure in the image that would reduce its filtration rate during hypovolemia or acute injury?", "Can you identify an organ that fails to concentrate urine effectively in chronic renal failure?", "Does the image show a structure that increases water reabsorption during dehydration?", "Is there an object whose ability to excrete waste products decreases in end-stage disease?", "Can you see a structure that alters electrolyte balance in response to acidosis by increasing hydrogen ion excretion?", "Is there an organ present that loses its capacity to regulate blood pressure in advanced chronic disease?", "Does the image contain a structure that increases erythropoietin production in response to hypoxia?", "Can you identify an object that shows impaired acid-base regulation during chronic disease?", "Is there a structure that reduces its function during acute tubular necrosis or glomerulonephritis?", "Does the image show an organ that increases sodium retention in heart failure?", "Can you see a structure that decreases potassium excretion in renal failure, potentially leading to hyperkalemia?", "Is there an object that enhances gluconeogenesis during prolonged fasting?", "Does the image contain a structure that fails to activate vitamin D efficiently in chronic disease?", "Can you identify an organ that increases its filtration rate during high protein intake?", "Is there a structure that reduces its detoxification role when exposed to nephrotoxic substances?", "Does the image show an object whose filtration barrier becomes more permeable during inflammation, resulting in proteinuria?", "Can you see a structure that decreases urine output in response to blood loss by conserving water and sodium?", "Is there an organ that increases renin secretion during low blood volume to restore homeostasis?", "Does the image contain a structure whose function improves after removal of an obstruction such as a stone or ureteral blockage?", "Can you identify an object that loses its ability to maintain osmotic balance in diabetes due to osmotic diuresis from hyperglycemia?"], "functions": ["Is there a structure in the image responsible for filtering blood and excreting waste products?", "Can you identify an organ that regulates fluid and electrolyte balance in the body?", "Does the image show a structure involved in hormone production, such as erythropoietin or renin?", "Is there an object that contains specialized filtration units like glomeruli?", "Can you see a structure that removes metabolites such as urea and creatinine from the bloodstream?", "Is there an organ that adjusts water reabsorption in response to hormonal signals?", "Does the image include a structure that selectively reabsorbs or excretes ions like sodium and potassium?", "Can you identify an object that helps control blood pressure through blood volume regulation and renin secretion?", "Is there a structure that contributes to acid-base balance by excreting hydrogen ions and reabsorbing bicarbonate?", "Does the image show an organ where urine is formed through filtration, reabsorption, secretion, and concentration?", "Is there a structure involved in the synthesis of hormones that regulate red blood cell production, blood pressure, or calcium metabolism?", "Can you see an organ that responds to low oxygen levels by secreting a hormone to stimulate red blood cell production?", "Is there a structure that activates vitamin D to its biologically active form for calcium absorption?", "Does the image include an organ that maintains calcium balance by regulating excretion and reabsorption of calcium?", "Can you identify a structure that filters and excretes xenobiotics and metabolic waste from the bloodstream?", "Is there an object that adjusts sodium and water reabsorption in response to changes in blood volume?", "Does the image show a structure performing regulatory functions to maintain homeostasis of fluids, electrolytes, pH, blood pressure, and hormone levels?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Are there signs of invasion into the seminal vesicles, bladder neck, rectum, or neurovascular bundles?", "Does the image suggest possible spread through lymphatic vessels, venous plexuses, or by direct extension?", "Can you observe blood vessels such as prostatic arteries, prostatic veins, or branches of the internal iliac vessels near the affected area?"], "contexual_behavior": [], "functions": []}}, "tube": {"yes_questions": {"contexual_properties": ["Is there a structure in the image whose central channel appears narrowed, possibly due to compression or scarring?", "Can you identify an object that shows an increased diameter, suggesting dilation or ectasia?", "Does the image reveal a structure with a blocked or occluded lumen, potentially due to a clot or foreign body?", "Is there evidence of discoloration in any elongated structure, which might indicate bleeding or pigment deposition?", "Can you see a structure with visibly thickened walls, possibly due to edema or cellular infiltration?", "Is there an elongated object whose wall appears unusually thin, suggesting atrophy or degeneration?", "Does any structure display irregular or uneven walls, which could be due to chronic inflammation or ulceration?", "Is there a visible accumulation of deposits, such as plaques or calculi, within or on the wall of a tubular structure?", "Can you identify a structure that appears fragile or weak, possibly due to congenital defects or degeneration?", "Does any elongated object in the image seem to have lost its normal elasticity, perhaps due to fibrosis or sclerosis?", "Is there a structure containing abnormal material, such as pus, blood, gas, or parasites, within its lumen?", "Can you see an object that appears rigid, possibly due to calcification or chronic inflammation?", "Is there evidence of swelling or edema in any elongated structure, suggesting inflammation or fluid accumulation?", "Does the image show a structure with signs of active inflammation or infection, such as redness or swelling?", "Is there a tubular structure that appears distended, possibly indicating increased internal pressure from obstruction?", "Can you identify an object that seems collapsed or underfilled, which might suggest decreased internal pressure or leakage?", "Is there evidence of leakage or rupture in any elongated structure, such as extravasation of contents?", "Does any structure appear unusually long or short, possibly due to stretching, contraction, or surgical modification?", "Is there a tubular object that appears twisted or kinked, suggesting torsion or volvulus?", "Can you see any abnormal surface features, such as polyps, nodules, or ulcers, on an elongated structure in the image?"], "properties": ["Is there an object in the image that appears hollow and elongated with a generally cylindrical shape?", "Can you identify a structure whose length and diameter vary depending on its application or use?", "Does the image show an object whose wall thickness might be specified in millimeters and influenced by material or pressure requirements?", "Is there a structure whose internal volume could be calculated from its length and internal diameter?", "Can you see an object that might be made of plastic, metal, glass, or rubber?", "Is there a structure whose color could be determined by its material or manufacturing process?", "Does the image contain an object with a surface texture that could be either smooth or textured depending on its function and material?", "Can you identify something whose weight would depend on its material, dimensions, and length?", "Is there an object whose flexibility might be influenced by its material composition and wall thickness?", "Does the image show a structure whose tensile strength could be determined by its material and structural design?", "Can you see an object whose ability to withstand maximum pressure might depend on its material, wall thickness, and diameter?", "Is there a structure whose transparency or opacity could be explained by its material properties?", "Does the image include an object whose density is defined by the material from which it is made?", "Can you identify something whose temperature resistance would be determined by its material properties?", "Is there an object whose chemical composition could be based on polymers or alloys depending on the material?", "Does the image show a structure where the inner surface roughness might affect flow and could be measured in micrometers?", "Can you see an object whose outer circumference could be calculated from its external diameter?", "Is there a structure whose cross-sectional area would be determined by its internal diameter?", "Does the image contain an object whose maximum flow rate could depend on its internal diameter, length, and surface roughness?"], "relational": ["Does the image show a structure that could be part of the respiratory, digestive, circulatory, urinary, or reproductive system?", "Can you identify an anatomical feature resembling the trachea, esophagus, a blood vessel, ureter, or fallopian tube?", "Is there a structure whose wall appears to be composed of layers such as epithelial tissue, smooth muscle, or connective tissue?", "Does the image contain an organ like the intestines, bronchi, ureter, or vas deferens that is formed from tubular structures?", "Can you see a structure located within the thoracic, abdominal, pelvic cavity, or limbs that appears tubular?", "Is there a feature that connects at both ends to other tubes, organs, or cavities?", "Does the image show a pathway that could transport substances within the body, similar to a duct or transport pathway?", "Can you identify a structure whose inner lining might be made up of epithelial cells, endothelial cells, or goblet cells?", "Is there evidence of a larger system, such as the vascular system, gastrointestinal tract, or respiratory tract, composed of multiple tubular structures?", "Does the image show an interaction between a tubular structure and glands, muscles, nerves, or connective tissue?"], "contexual_behavior": ["Does the image show a structure where fluid transport might be impaired due to a visible blockage or narrowing?", "Is there an object that could exhibit increased flow if subjected to elevated internal pressure?", "Can you identify a structure that appears swollen or narrowed, suggesting inflammation and reduced transport capacity?", "Does the image contain a structure that might be prone to leakage if its wall integrity is compromised?", "Is there evidence of mucosal damage or abnormal secretions that could indicate altered permeability due to infection?", "Can you see any signs of tears, perforations, or fibrosis that would suggest structural damage and impaired function?", "Does the image show a structure whose lining appears disrupted, possibly due to chemical exposure increasing permeability?", "Is there a region where reduced fluid volume or increased viscosity might indicate dehydration and decreased transport?", "Can you identify a structure whose flow dynamics might change during physical exertion, such as through visible muscle contraction or pressure changes?", "Is there evidence of loss of directional flow, possibly due to valve dysfunction or motility disorder?", "Does the image suggest that a therapeutic intervention, such as stenting or dilation, has improved the efficiency of a structure's transport function?", "Can you see a structure that appears susceptible to collapse, especially under low pressure or with weakened support?", "Is there visual evidence of remodeling or expansion that could indicate functional adaptation during growth or development?", "Does the image show persistent obstruction that might be associated with chronic conditions like fibrosis or chronic inflammation?", "Is there a structure that could be playing an increased role in waste removal during metabolic stress, as suggested by enhanced flow or upregulated transport features?"], "functions": ["Does the image show a structure that provides a passage for fluids or gases between different regions of the body?", "Can you identify an object that enables the directed movement of substances through a continuous lumen?", "Is there a feature that connects two organs or tissues by forming an anatomical pathway?", "Does the image contain a structure that could regulate the flow of substances, possibly through muscular contraction or valves?", "Can you see something that might facilitate nutrient absorption or waste removal by transporting materials to sites of absorption or excretion?", "Is there an object that could serve as an airway, conducting air to or from the lungs for gas exchange?", "Does the image include a structure that could be involved in circulating blood or lymph throughout the body?", "Can you identify a feature that might channel fluids such as bile, urine, or sweat from glands or organs to their destinations?", "Is there a structure that appears to help maintain pressure or volume within an organ by allowing expansion or contraction?", "Does the image show an object that could provide a route for the delivery of hormones or signaling molecules via the bloodstream or ducts?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see a structure measuring about 7 centimeters in width and 1 centimeter in height?", "Is there evidence of a bone whose mineral content is predominantly hydroxyapatite?", "Is there a visible gap of 2 millimeters between two adjacent vertebrae at the atlanto-dens interval?"], "relational": ["Does the image show a structure located in the cervical region of the spine?", "Is there evidence of a joint between the occipital bone and the first cervical vertebra?", "Can you see any ligaments such as the transverse or alar ligaments associated with the upper cervical spine?"], "contexual_behavior": [], "functions": ["Does the image show evidence of impaired alignment in the upper cervical spine?", "Are there signs of restricted head or neck movement, such as decreased range of motion or cervical stiffness?", "Can you identify disruptions in neural conduction, vascular flow, or musculoskeletal integrity in the cervical region?"]}}}
[ { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "beckwith-wiedemann syndrome" ], "question": "is beckwith-wiedemann syndrome present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "colon" ], "question": "is colon present?" }, { "answer": "no", "extracted_concepts": [], "question": "is very good example present?" }, { "answer": "villous adenoma", "extracted_concepts": [ "villous adenoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "villous adenoma" ], "question": "is villous adenoma present?" }, { "answer": "no", "extracted_concepts": [ "gangrene" ], "question": "is gangrene present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "colon", "extracted_concepts": [ "colon" ], "question": "what is present?" }, { "answer": "villous adenoma", "extracted_concepts": [ "villous adenoma" ], "question": "what is present?" } ]	["beckwith-wiedemann syndrome", "villous adenoma", "colon", "gastrointestinal", "gastrointestinal system", "gangrene"]	{"beckwith-wiedemann syndrome": {"yes_questions": {"contexual_properties": ["Is there evidence of organ enlargement that could have developed before or shortly after birth?", "Does the image show signs of increased birth weight or fetal overgrowth?", "Can you identify asymmetric limb growth that might be present from birth or early childhood?", "Is there an enlarged tongue visible, particularly in a newborn or infant?", "Does the image reveal any abdominal wall defects, such as omphalocele or umbilical hernia, that are apparent at birth?", "Are there indications of low blood glucose, especially in a neonate?", "Can you see signs of kidney enlargement that may be present prenatally or in early childhood?", "Is there any facial appearance suggestive of midface hypoplasia or prominent eyes in an infant?", "Does the image suggest a predisposition to embryonal tumors, especially in a child?", "Are there visible changes in organ structure, such as altered tissue architecture or cellular overgrowth, in early development?", "Can you detect abnormal ear creases or pits, such as posterior helical pits, present at birth?", "Is there evidence of accelerated somatic growth, particularly in the prenatal or early postnatal period?", "Does the image suggest increased amniotic fluid volume, which might be detected during pregnancy?", "Can you see signs of an enlarged placenta during pregnancy?", "Are there indications of abnormal tissue composition, such as increased mesenchymal tissue or organ hyperplasia, in early life?"], "properties": ["Does the image show an individual with features such as excessive body size or rapid linear growth during infancy?", "Is there evidence of a tongue that appears unusually large compared to the oral cavity?", "Can you identify any organs that appear enlarged relative to typical pediatric anatomy?", "Is there asymmetry in limb or body size suggestive of hemihyperplasia?", "Does the abdominal region display signs of wall defects, such as an omphalocele or umbilical hernia?", "Is the birth weight or overall size of the infant above the 90th percentile for age and sex?", "Does the head circumference appear disproportionately large, possibly exceeding the 90th percentile?", "Are there facial features such as midface hypoplasia, prominent eyes, or visible ear creases or pits?", "Can you observe any signs of nephromegaly, such as visibly enlarged kidneys?", "Is there evidence of tall stature in the child, with height above the 90th percentile for age?", "Does the image suggest the presence of tumors such as Wilms tumor or hepatoblastoma?", "Are there visual indications of neonatal hypoglycemia, such as lethargy or abnormal feeding behavior?", "Can you see any laboratory findings or annotations indicating elevated insulin levels or abnormal methylation at the 11p15 region?", "Is there an umbilical hernia or omphalocele present in the abdominal area?", "Are there any visible signs of organomegaly affecting multiple organs?", "Does the image show a child with features that typically present at birth or in the neonatal period?", "Are there ear creases or pits visible on the external ear in the image?", "Is there evidence of both macroglossia and organomegaly in the same individual?"], "relational": ["Does the image show evidence of overgrowth in soft tissue, muscle, or connective tissue?", "Can you identify any asymmetry in the limbs or face suggestive of hemihyperplasia?", "Is there visible enlargement of the tongue or other features consistent with macroglossia?", "Does the image reveal abnormalities in the abdominal wall, such as incomplete closure or omphalocele?", "Are there signs of visceromegaly, such as an enlarged abdomen or prominent abdominal organs?", "Can you see any features indicating enlargement of the kidneys, liver, or limbs?", "Is there evidence of structural changes in the ear, such as creases or pits?", "Does the image suggest increased size or abnormal appearance of the pancreas or adrenal glands?", "Are there visual cues of altered tissue growth regulation in the musculoskeletal or lymphatic systems?", "Can you observe any changes in embryonic-derived structures, such as the abdominal wall or somatic tissues?", "Is there any indication of tumor risk in abdominal organs like the kidneys or liver?", "Does the image show involvement of multiple organ systems, such as endocrine, digestive, or genitourinary systems?", "Are there visible changes in the face, abdomen, or limbs that could be associated with a congenital overgrowth syndrome?"], "contexual_behavior": ["Does the image show evidence of abnormal growth regulation during fetal development or early childhood, possibly due to disruptions in imprinted gene expression?", "Is there a visible indication of increased risk for embryonal tumors, such as Wilms tumor or hepatoblastoma, particularly in a child?", "Can you identify features suggestive of metabolic dysfunction in infancy, such as signs of hypoglycemia or pancreatic islet cell hyperplasia?", "Does the image display signs of persistent hypoglycemia or disrupted glucose homeostasis during the neonatal period or early infancy?", "Is there evidence of organ overgrowth affecting the liver, kidneys, or tongue during prenatal development or early childhood?", "Can you see indications of abnormal hormone secretion in infancy or childhood, such as increased insulin production or pancreatic beta-cell hyperplasia?", "Does the image suggest postprandial hypoglycemia or impaired blood sugar regulation after feeding in a newborn?", "Is there any sign of susceptibility to hypoglycemia during fasting in a newborn or infant, possibly due to dysregulated insulin secretion?", "Can you identify features that might indicate metabolic instability or increased risk of hypoglycemia in response to surgical stress at any age?", "Does the image show structural anomalies such as nephromegaly or adrenal cytomegaly, suggesting altered kidney or adrenal gland function during childhood?", "Is there any evidence of secondary effects on the immune system during early development, even if immune dysfunction is not the primary feature?", "Can you observe signs of altered growth factor response, such as changes in IGF2 expression, affecting development?", "Does the image reveal abnormal placental function during pregnancy, such as placentomegaly or related complications?", "Is there any indication of impaired wound healing or tissue regeneration in a child, possibly due to altered cellular proliferation or growth factor signaling?", "Can you see signs of increased metabolic rate or anabolic activity during childhood, potentially associated with organ overgrowth?", "Does the image suggest impaired regulation of cell proliferation during embryonic or early postnatal development, possibly due to loss of imprinting at growth-regulating loci?", "Is there evidence of altered defense against oxidative stress during early life, even if this is not a primary clinical feature?", "Can you identify features of hepatomegaly or metabolic disturbances affecting liver function during neonatal development?", "Does the image show generalized or organ-specific overgrowth in infancy or childhood, indicating increased anabolic activity?", "Is there any indication of reduced effectiveness of normal growth suppression mechanisms throughout development, possibly due to epigenetic alterations affecting growth-regulatory genes?"], "functions": ["Does the image show evidence of generalized overgrowth or organ enlargement?", "Can you identify any signs of abnormal growth regulation, such as excessive prenatal or postnatal size?", "Is there visual evidence of metabolic imbalance, such as features suggestive of neonatal hypoglycemia?", "Does the image display enlargement of specific organs, such as the tongue, kidneys, or liver?", "Can you see any indications of abnormal insulin secretion or altered growth factor signaling?", "Is there evidence of increased cellular proliferation or abnormal tissue growth?", "Does the image suggest a predisposition to embryonal tumors, such as Wilms tumor or hepatoblastoma?", "Are there features consistent with glucose dysregulation, particularly in a neonatal context?", "Can you observe abnormal growth patterns or asymmetry in organ development?", "Is there visual evidence of altered sensitivity to growth signals, possibly due to changes in growth factor pathways?"]}, "no_questions": {"contexual_properties": ["Is there evidence of fibrosis in a duct-like structure, as seen in chronic liver diseases such as primary biliary cholangitis?", "Are there regions where staining properties of a ductular structure are altered, as might be observed in cholestasis or during a ductular reaction?", "Is there evidence of increased branching in a ductular network, which might be seen during regeneration or chronic injury?"], "properties": ["Can you identify a structure that measures approximately 50 to 100 micrometers in length?", "Is there evidence of a bile flow rate through a small duct at about 0.5 to 1.0 microliters per minute per gram of liver?", "Is there a feature lined by both hepatocytes and cholangiocytes?"], "relational": ["Does the image contain a region lined by both cholangiocytes and hepatocytes?", "Is there a conduit visible between bile canaliculi and interlobular bile ducts?", "Is there a visible connection between hepatic lobules and portal triads within the biliary system?"], "contexual_behavior": [], "functions": ["Can you see a region that could serve as a niche for hepatic progenitor cells involved in liver regeneration?", "Is there a specialized microenvironment present that supports the maintenance and activation of hepatic progenitor cells?", "Does the image show a structure that could supply progenitor cells for liver repair or repopulation of damaged hepatic or biliary tissue?"]}}, "villous adenoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion associated with the gastrointestinal system?", "Can you identify an abnormal structure located in the colon, rectum, or duodenum?", "Is there a lesion primarily involving the mucosal layer and possibly extending into the submucosa?", "Does the image contain a structure surrounded by mucosa, submucosa, and muscularis propria?", "Can you see a lesion adjacent to the intestinal lumen or nearby mucosa?", "Is there an area composed of epithelial cells, goblet cells, or dysplastic glandular cells?", "Does the image show a lesion arising from and confined to the colonic mucosa?", "Can you identify an abnormality within the large intestine, colon, or rectum?", "Is there a lesion structurally similar to a tubular adenoma, tubulovillous adenoma, or hyperplastic polyp?", "Does the area containing the lesion appear to be supplied by branches of the superior or inferior mesenteric artery?"], "contexual_behavior": ["Is there a lesion in the image that appears to secrete excessive mucus, possibly indicating increased mucin production?", "Can you identify a structure that disrupts the normal mucosal architecture and may impair absorption in the colon?", "Does the image show a lesion that could be responsible for electrolyte imbalance, such as hypokalemia, due to secretion of potassium-rich mucus?", "Is there evidence of increased epithelial cell proliferation, possibly in response to chronic inflammation?", "Can you see a structure that might display features of high-grade dysplasia or other signs of malignant potential?", "Is there a lesion with disrupted or ulcerated epithelial lining, suggesting reduced barrier function against pathogens?", "Does the image contain a mass that could interfere with colonic motility, either by causing partial obstruction or irritating the muscularis propria?", "Can you identify a structure that might be associated with excessive watery mucus production, potentially leading to fluid loss or secretory diarrhea?", "Is there evidence of impaired nutrient absorption, possibly due to rapid transit or mucosal damage associated with diarrhea?", "Does the lesion appear to show changes in secretory behavior that could be influenced by hormonal factors such as prostaglandins or secretin?", "Is there a structure with signs of epithelial breakdown, possibly resulting from oxidative stress?", "Can you see a lesion that appears metabolically active, suggesting rapid growth and increased cellular proliferation?", "Is there evidence of disrupted mucosal homeostasis, such as abnormal epithelial renewal or dysplastic changes?", "Does the image show a mass with features suggesting impaired apoptosis and uncontrolled cellular proliferation?", "Can you identify a structure that may have accumulated genetic alterations due to carcinogen exposure, indicating neoplastic progression?"], "functions": ["Does the image show a lesion characterized by epithelial proliferation or dysplasia?", "Can you identify a structure that appears to disrupt normal mucosal integrity or alter absorption?", "Is there evidence of increased mucous secretion or mucous hypersecretion in the tissue?", "Does the image reveal abnormal glandular architecture, such as villous projections or disorganized glands?", "Can you see features that might indicate excessive mucous production leading to electrolyte loss or secretory diarrhea?", "Is there a region that could be associated with impaired barrier function or local inflammation?", "Does the tissue display changes that could promote malabsorption or reduce surface area?", "Is there a structure that might stimulate goblet cells, resulting in profuse mucous output?", "Can you identify areas where local immune response or inflammatory cell infiltration is evident?", "Does the image suggest irritation-induced hyperperistalsis or altered colonic motility?", "Is there a lesion that could be associated with high-grade dysplasia or risk of progression to adenocarcinoma?", "Can you see evidence of changes that might disturb electrolyte and fluid balance, such as signs of potassium loss or dehydration?"]}, "no_questions": {"contexual_properties": ["Can you identify an abnormal mass that appears different in texture or color compared to surrounding tissues?", "Is there a structure that could represent a secondary growth from a primary tumor elsewhere in the body?", "Is there a visible lesion that might suggest the spread of malignant cells to a new location?"], "properties": [], "relational": ["Is there a region that might contain malignant epithelial cells, stromal cells, or inflammatory cells?", "Is there evidence of a secondary tumor that may have originated from a different primary neoplasm?", "Does the image show a lesion adjacent to blood vessels, nerves, or surrounding parenchyma?"], "contexual_behavior": [], "functions": ["Does the image contain a mass that appears to support further tumor growth or invasion into adjacent tissues?", "Does the image reveal a mass that might be compressing blood vessels or causing abnormal new vessel formation?", "Can you identify an area where normal organ architecture is lost, potentially leading to impaired function?"]}}, "colon": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify regions such as the ascending, transverse, descending, or sigmoid segments within the image?", "Is there a structure that appears adjacent to the small intestine or rectum?", "Can you see any anatomical features located near the kidneys or bladder?", "Does the image contain vessels that could correspond to the superior or inferior mesenteric arteries supplying a digestive organ?", "Is there evidence of innervation by the enteric nervous system or by fibers from the vagus or pelvic splanchnic nerves in any visible structure?", "Can you identify a region that is continuous with the rectum at its terminal end?", "Is there a visible junction where the ileum meets a larger tubular structure, possibly involving the ileocecal valve?", "Does the image show a wall composed of multiple layers such as mucosa, submucosa, muscularis propria, and serosa?", "Are there lymphatic structures present, such as mesenteric or colic lymph nodes, associated with a tubular digestive organ?", "Can you identify anatomical boundaries such as the ileocecal junction or rectosigmoid junction in the image?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for absorbing water from digested food?", "Can you identify an area involved in regulating electrolyte levels, such as sodium and chloride absorption?", "Is there a region where undigested carbohydrates might be fermented by anaerobic bacteria?", "Does the image contain a structure that compacts waste material and stores it until elimination?", "Can you see evidence of an environment that supports the proliferation of beneficial gut microbiota?", "Is there a visible area where vitamins like vitamin K and B vitamins could be absorbed after being synthesized by resident bacteria?", "Does the image show a structure that propels fecal matter toward the rectum for excretion?", "Can you identify a region involved in maintaining fluid balance through water and electrolyte reabsorption?", "Is there a structure present that contributes to immune defense via gut-associated lymphoid tissue or antimicrobial peptide production?"]}, "no_questions": {"contexual_properties": ["Is there evidence of changes in cellular composition or differentiation within a lesion, possibly due to tumor progression or therapy response?", "Does the image reveal cystic areas or fluid-filled spaces within a mass, which could result from necrosis or degeneration?", "Can you identify regions with increased expression of tumor-associated markers or proteins, as might be seen with upregulation in neoplastic tissue?"], "properties": ["Do you observe cells with scant cytoplasm that appears either basophilic or eosinophilic?", "Is there evidence of moderate or poor cellular differentiation, suggesting an intermediate or high histological grade?", "Does the image contain tissue with an elevated number of mitotic figures compared to normal tissue?"], "relational": ["Is there evidence of abnormal growth affecting the respiratory, digestive, urinary, or reproductive systems?", "Can you see any indication of malignant transformation within epithelial tissue?", "Does the image show a lesion arising from epithelial or glandular tissue?"], "contexual_behavior": ["Can you observe changes in hormone receptor expression or downstream signaling in response to hormonal fluctuations?", "Is there disruption of normal tissue architecture or replacement of functional cells, indicating impaired tissue function as a lesion progresses?", "Can you identify regions where proteolytic enzyme activity may be degrading the extracellular matrix during tissue invasion?"], "functions": ["Does the image show features that might indicate local inflammation, such as increased presence of inflammatory cells or cytokine activity?", "Does the image suggest the presence of cells that could be resistant to therapy, for example, by showing persistent abnormal cell populations despite apparent treatment effects?", "Is there evidence of tissue where the normal architecture is disrupted, suggesting replacement of healthy cells and possible organ dysfunction?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure in the image supplied by the ovarian artery and ovarian vein?", "Does the image show a lesion associated with the female reproductive system?", "Does the mass have boundaries defined by the ovarian capsule or nearby pelvic structures?"], "contexual_behavior": [], "functions": ["Is there any indication of cellular atypia within the epithelial lining of a cystic ovarian structure?", "Does the image show features consistent with a low risk of malignant transformation, such as minimal stromal invasion?", "Is there evidence of cyst rupture or irritation of surrounding tissue that might induce a local inflammatory response?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of bone margins around an opening that are thicker than 5 mm?", "Is the sagittal diameter of the visible opening less than 30 mm?", "Is there an area where bone density seems increased, potentially above 1200 Hounsfield units on CT imaging?"], "relational": ["Does the image show alterations in the occipital bone, such as thickening or abnormal shape?", "Can you identify changes affecting the posterior cranial fossa or craniovertebral junction?", "Are the cerebellar tonsils or lower brainstem positioned unusually close to the bony margins of the craniovertebral junction?"], "contexual_behavior": [], "functions": ["Can you identify any signs of compression at the lower brainstem or upper spinal cord that could disrupt neural signal transmission?", "Does the image reveal pressure on regions responsible for autonomic or motor control, suggesting impaired brainstem function?", "Does the image show evidence of compression affecting neural or vascular structures that could result in neurological deficits?"]}}, "gangrene": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show an area of tissue that appears dark brown, black, or greenish in color?", "Can you identify a region with a dry, shriveled, or alternatively soft and moist texture?", "Is there evidence of tissue that might be associated with a foul, putrid, or sweetly offensive odor?", "Does the tissue in any area appear to have reduced water content or seem unusually moist compared to surrounding areas?", "Is there a region that could have an acidic environment due to tissue breakdown or bacterial activity?", "Can you see an area of tissue that appears cooler or less perfused than the surrounding healthy tissue?", "Is there a localized or extensive area of tissue damage visible in the image?", "Does any tissue region appear to have low or high moisture levels, suggesting different types of tissue breakdown?", "Is there visual evidence of gas accumulation, such as bubbles or swelling, that could indicate gas-producing bacteria?", "Can you identify tissue that might have altered protein composition, such as denatured or degraded structural proteins?", "Is there an area where the fat content appears reduced, possibly due to fat necrosis or tissue breakdown?", "Does the image show tissue that could contain necrotic cells, inflammatory cells, or bacterial colonies?", "Are there regions where cellular detail is lost, or where necrosis and possible bacterial presence might be observed under magnification?", "Can you identify areas where the rate of tissue necrosis appears rapid or slow, based on the extent and appearance of tissue damage?", "Is there a region of tissue that seems to have decreased density, possibly due to tissue breakdown or gas formation?"], "relational": ["Does the image show evidence of tissue damage affecting the skin, subcutaneous tissue, or muscle?", "Is there visible involvement of the lower limbs, toes, fingers, or feet in the abnormality present?", "Can you identify any signs of tissue compromise in organs such as the intestines, lungs, or gallbladder?", "Are there indications of disrupted arteries, veins, or capillaries in the affected area?", "Does the image suggest impaired blood flow, vascular occlusion, or ischemia in any region?", "Is there evidence of damage to epithelial, muscle, or endothelial cells in the depicted tissue?", "Can you observe necrosis, ulceration, or tissue breakdown involving the skin?", "Are any digits, the foot, ankle, or lower leg visibly affected by pathological changes?", "Do you see anatomical barriers such as fascia, connective tissue septa, or joint capsules that appear to limit the spread of the abnormality?", "Is there structural compromise of the integumentary, musculoskeletal, or vascular systems visible in the image?"], "contexual_behavior": [], "functions": ["Is there evidence of a pathological process characterized by tissue necrosis or cell death in the image?", "Can you identify an area where oxygen deprivation or irreversible tissue damage is apparent?", "Does the image show signs of disrupted blood supply, such as vascular occlusion or impaired perfusion?", "Is there a region that suggests bacterial proliferation or toxin release leading to breakdown of tissue barriers?", "Can you observe features consistent with hypoxia, enzymatic degradation, or inflammatory damage to tissue?", "Is there visible evidence of an exaggerated inflammatory response, such as leukocyte infiltration, cytokine release, or edema?", "Does the image indicate systemic toxicity, such as signs of sepsis or multi-organ dysfunction?", "Can you identify an area where wound healing appears impaired due to persistent infection or poor vascularization?", "Is there a region that suggests loss of function, increased risk of amputation, or sensory deficits in an organ or limb?", "Does the image show signs of reduced phagocytic activity, disrupted barrier integrity, or increased pathogen invasion at a local site?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see a region whose lymphatic drainage is associated with parametrial, internal iliac, or obturator lymph nodes?", "Does the image contain a portion of tissue that is contiguous with the endocervix at the squamocolumnar junction?", "Can you identify a region composed mainly of non-keratinized stratified squamous epithelium and underlying connective tissue?"], "contexual_behavior": ["Does the image show evidence of impaired mucus production or gland dysfunction due to inflammation?", "Is there a region that appears to have reduced barrier function against pathogens, possibly indicating increased susceptibility to infection?", "Can you see any indication that the passage of sperm might be hindered due to altered mucus quality or changes in the cervical environment?"], "functions": ["Is there a structure that could be modulating its local microenvironment, for example by showing changes in pH-sensitive staining or altered cellular composition?", "Is there evidence of increased vascular permeability, such as swelling or redness, in any mucosal area?", "Is there a visible increase in mucus production or changes in mucus appearance that could indicate altered mucin content?"]}}}
[ { "answer": "med pas hematoxylin section of mucosa excellent example source", "extracted_concepts": [ "med pas", "hematoxylin", "mucosa", "section of mucosa" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "hematoxylin", "mucosa", "section" ], "question": "does this image show med pas hematoxylin section of mucosa excellent example source?" }, { "answer": "no", "extracted_concepts": [ "autopsy", "hematoxylin", "mucosa", "section of mucosa" ], "question": "does autopsy show med pas hematoxylin section of mucosa excellent example source?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "test tube", "pus" ], "question": "is pus in test tube present?" }, { "answer": "intestine", "extracted_concepts": [ "intestine" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "intestine" ], "question": "is intestine present?" }, { "answer": "no", "extracted_concepts": [ "hemorrhage", "placental abruption" ], "question": "is hemorrhage associated with placental abruption present?" }, { "answer": "whipples disease", "extracted_concepts": [ "whipples disease" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "whipples disease" ], "question": "is whipples disease present?" }, { "answer": "no", "extracted_concepts": [], "question": "is child present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system" ], "question": "where is this from?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "intestine", "extracted_concepts": [ "intestine" ], "question": "what is present?" }, { "answer": "whipples disease", "extracted_concepts": [ "whipples disease" ], "question": "what is present?" } ]	["hemorrhage", "hematoxylin", "intestine", "autopsy", "med pas", "mucosa", "test tube", "section of mucosa", "gastrointestinal", "whipples disease", "placental abruption", "gastrointestinal system", "section", "pus"]	{"hemorrhage": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of disruption in vascular tissue within the cardiovascular or nervous system?", "Is there a region where blood appears to have infiltrated connective or muscle tissue?", "Can you identify signs of damage to arteries, veins, or capillaries in the depicted area?", "Is there visual evidence of tissue compression or swelling that could indicate hematoma formation?", "Does the image display abnormal accumulation of blood in the cranial, pleural, pericardial, or peritoneal cavity?", "Are there signs of blood collection within muscular compartments or subcutaneous tissue?", "Can you see any indication of edema in regions adjacent to blood vessels?", "Is there evidence of blood affecting organs such as the brain, liver, spleen, kidneys, or lungs?", "Does the image suggest that anatomical barriers like fascia, meninges, or peritoneum are limiting the spread of a fluid collection?", "Are there visual cues that suggest involvement of nervous tissue or nerves due to nearby vascular disruption?", "Can you identify blood accumulation in joint spaces or within joint capsules?", "Is there a region where surrounding organs appear affected by a nearby vascular event?", "Does the image show signs of blood infiltration in the gastrointestinal tract, lungs, skin, or muscles?"], "contexual_behavior": [], "functions": ["Does the image show evidence of reduced blood volume or impaired circulation?", "Can you identify signs of decreased tissue perfusion or organ dysfunction?", "Is there visual indication of compensatory mechanisms such as vasoconstriction or tachycardia?", "Does the image suggest diminished oxygen delivery to tissues, such as pallor or cyanosis?", "Can you see features that might indicate activation of the coagulation cascade or clot formation?", "Is there evidence of decreased blood pressure or lowered vascular resistance in the depicted structures?", "Does the image show signs consistent with shock, such as inadequate perfusion or cellular hypoxia?", "Can you identify areas with reduced perfusion or possible nutrient and oxygen deficiency?", "Is there visual evidence of the body attempting to restore homeostasis, such as fluid redistribution or increased heart rate?", "Does the image suggest increased erythropoiesis or compensatory responses to oxygen deficit?", "Can you see indications of impaired organ function or reduced blood supply that could lead to organ failure?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a part of the image that might have a water content similar to other skin tissues, around 60 to 70 percent?", "Can you see a structure that might contain between 4 and 18 small openings on its surface?", "Does the image show a region with a cylindrical or conical shape?"], "relational": ["Is there an object positioned on the anterior thoracic region of the body?", "Can you identify an area supplied by branches of the internal thoracic or lateral thoracic arteries?", "Can you see a structure that serves as the external outlet for milk secretion?"], "contexual_behavior": [], "functions": ["Can you identify an area that provides an accessible point for infant latch during breastfeeding?", "Does the image show a structure capable of regulating milk flow through smooth muscle contraction in response to suckling?", "Can you identify an area that provides tactile or olfactory cues important for infant feeding behavior?"]}}, "hematoxylin": {"yes_questions": {"contexual_properties": ["Is there evidence in the image of a staining agent that has changed color, possibly due to oxidation or exposure to alkaline conditions?", "Can you observe areas where the staining appears more intense, suggesting increased concentration from evaporation or addition of more reagent?", "Does the image show regions with lighter staining that could indicate dilution from the addition of water or alcohol?", "Are there visible precipitates or crystals that might result from oversaturation or storage at low temperatures?", "Can you identify tissue sections with decreased staining intensity, possibly due to prolonged exposure to light, air, or improper storage?", "Is there any indication of uneven staining that could be caused by poor mixing of the staining solution or inadequate tissue preparation?", "Do you see signs of fading in the stained areas, which might result from light exposure, air, or improper mounting?", "Is there evidence of microbial contamination or degradation, such as unexpected discoloration or particulate matter in the stained sample?", "Can you detect changes in staining that might be related to altered pH, such as after mixing with acidic or basic substances?", "Are there regions where the staining agent appears less soluble, possibly due to low temperature or incompatible solvents?", "Does the image suggest that the composition of the staining agent has changed, perhaps due to exposure to air, light, or temperature fluctuations during storage?", "Can you observe areas where staining intensity is increased, potentially due to higher concentration of the agent or prolonged staining time?"], "properties": ["Is there a substance in the image that could have the chemical formula C16H14O6?", "Can you identify a material that is colorless to pale yellow in its pure form?", "Does the image show crystals that appear as colorless to pale yellow prisms or needles?", "Is there evidence of a compound with low water solubility but high solubility in alcohols such as ethanol or methanol?", "Can you see a sample that would be stable if protected from light and air?", "Is there a solution present that might have a pH between 2.0 and 3.5?", "Does the image include a substance that could be used at concentrations between 0.1% and 1% w/v in staining protocols?", "Is there a material that, after oxidation, could show absorption maxima at wavelengths of 560 nm and 590 nm?", "Can you identify a compound that might have a density around 1.68 g/cm\u00b3?", "Is there a substance with a refractive index close to 1.650?", "Does the image show a chemical that is typically available at a purity level of at least 98%?", "Is there any indication of a compound that, in its active form, would be in a quinone or oxidized state?", "Can you see evidence of a substance with a melting point in the range of 220\u2013223\u00b0C?", "Is there a material present that could have a molecular weight of approximately 302.28 g/mol?"], "relational": ["Does the image show prominent staining of nuclear regions or basophilic areas within cells?", "Can you identify structures such as cell nuclei, chromatin, or nucleoli that are distinctly stained?", "Is there evidence of staining that highlights DNA, RNA, or nuclear proteins in the tissue?", "Does the image contain epithelial, connective, or muscle tissue with visible nuclear staining?", "Can you see epithelial cells, lymphocytes, neurons, or muscle cells with their nuclei clearly marked?", "Are there regions in the tissue section where nuclei or chromatin are more intensely stained than the surrounding cytoplasm?", "Is there a visual indication that another stain, such as eosin, periodic acid-Schiff, or Masson's trichrome, has been used alongside the nuclear stain?", "Does the tissue section appear to be from an organ system such as the nervous, digestive, respiratory, or reproductive system, with nuclear features highlighted?", "Can you observe nuclear staining patterns that differentiate between various cell types in the tissue?"], "contexual_behavior": ["Does the image show cell nuclei with reduced staining intensity that could indicate exposure to acidic conditions?", "Can you identify areas where nuclear material appears unstained or faint, possibly due to necrosis and chromatin loss?", "Is there evidence of enhanced nuclear specificity that might result from the use of aluminum or iron salts during staining?", "Do the nuclear structures appear indistinct or blurred, suggesting possible over-fixation of the tissue?", "Are there regions where nuclear staining is weak, which could be due to prolonged dehydration of the sample?", "Does the image display staining variability in areas with high lipid content, such as uneven or patchy nuclear coloration?", "Can you observe enhanced nuclear contrast that might result from antigen retrieval procedures restoring chromatin structure?", "Are there tissue regions where nuclei are absent or unstained, potentially due to excessive autolysis?", "Is there evidence of unreliable or patchy nuclear staining that could be caused by heavy metal contamination?", "Do you see increased background staining in non-nuclear areas, which might indicate suboptimal washing conditions?"], "functions": ["Does the image show cell nuclei that are distinctly visible due to a specific staining procedure?", "Can you observe blue or purple coloration highlighting nuclear material within the tissue?", "Is there evidence of a stain that binds to DNA and RNA, resulting in enhanced visualization of chromatin?", "Does the image display tissue architecture where nuclei are clearly delineated from the surrounding cytoplasm?", "Can you identify basophilic structures, such as nuclei or ribosomal RNA, that are selectively stained?", "Is there a contrast between nuclear features and other cellular or extracellular components, suggesting the use of a counterstain?", "Does the image facilitate the assessment of cellular morphology by providing enhanced contrast to nuclear material?", "Can you see nuclear highlighting that aids in the identification of structural organization within the tissue?", "Is there visual evidence of a staining agent that enables differentiation of cellular elements in a pathological context?"]}, "no_questions": {"contexual_properties": ["Can you identify regions with diffuse or multifocal lymphatic channel involvement?", "Does the image show any abnormal proliferation of lymphatic vessels?", "Is there evidence of a condition affecting multiple organs or tissues through lymphatic vessel overgrowth?"], "properties": ["Is there evidence of tissue composed predominantly of lymphatic vessels and connective tissue?", "Are there structures that appear translucent, pale, or yellowish in color?", "Are there masses that seem to grow slowly and progressively over time?"], "relational": ["Does the image reveal involvement of anatomical regions such as the thorax, abdomen, bones, or skin?", "Can you see any lesions present in the pleural or peritoneal cavity, or the mediastinum?", "Is there evidence of abnormal proliferation within lymphatic structures?"], "contexual_behavior": [], "functions": ["Are there signs that immune surveillance might be decreased, such as limited movement of antigen-presenting cells or lymphocytes?", "Is there evidence of impaired absorption of dietary fats, such as changes in intestinal structures responsible for chylomicron transport?", "Does the image show evidence of abnormal proliferation of vessels that could indicate multi-organ dysfunction?"]}}, "intestine": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify regions that could correspond to both a small and a large tubular organ within the abdomen?", "Is there a structure that appears directly connected to the stomach or the cecum?", "Does the image display any features that might indicate a connection to the anus?", "Can you see evidence of blood vessels such as branches of the superior or inferior mesenteric arteries supplying a tubular organ?", "Is there a structure that could be innervated by the enteric nervous system or vagus nerve?", "Does the image show a wall with multiple layers, such as mucosa, submucosa, muscularis externa, and serosa?", "Can you identify lymphatic structures like Peyer's patches or mesenteric lymph nodes associated with a tubular organ?", "Is there a visible feature that could represent the ileocecal valve separating two regions of a tubular structure?", "Does the image show an organ suspended within the abdominal cavity by a mesentery?", "Can you see an inner lining that might be composed of simple columnar epithelium with goblet cells?", "Is there a structure adjacent to the liver, pancreas, or spleen?", "Does the image reveal connections to ducts such as the bile duct or pancreatic duct, or to the anal canal?"], "contexual_behavior": [], "functions": ["Does the image show a structure involved in nutrient absorption and water reabsorption?", "Can you identify a region lined with villi or microvilli to increase surface area for uptake?", "Is there evidence of specialized epithelial cells that facilitate absorption of nutrients?", "Does the image contain a structure responsible for enzymatic breakdown of macromolecules?", "Can you see an area where water is reclaimed to maintain fluid balance, such as the colon?", "Is there a region where undigested material is compacted to form waste for excretion?", "Does the image show tissue associated with gut-associated lymphoid structures or immune cell production?", "Can you identify smooth muscle layers that might be involved in coordinated contractions for motility?", "Is there a visible feature suggesting the presence of beneficial microbes or maintenance of gut flora balance?", "Does the image show any structures that could be involved in absorbing or secreting ions like sodium or potassium?", "Can you see evidence of digestive enzymes or microbial fermentation enabling nutrient release?", "Is there an area that might contain enteroendocrine cells responsible for gut hormone secretion?", "Does the image show a physical barrier or tissue involved in immune defense or antimicrobial secretion?", "Can you identify features that suggest absorption of fat-soluble vitamins or vitamin B12?", "Is there evidence of a process or structure involved in recycling bile salts for fat digestion?", "Does the image show any indication of neuroregulation, such as connections to the enteric nervous system or vagus nerve?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see a mass or lesion that appears to invade deeper structures such as the dermis, submucosa, muscle, or blood vessels?", "Does the abnormality appear to impact systems like the integumentary, respiratory, digestive, or reproductive system?", "Does the image show an abnormality in tissues lined by squamous epithelium, such as the skin or mucous membranes?"], "contexual_behavior": [], "functions": ["Can you identify areas where tissue architecture is disrupted, suggesting invasion into surrounding structures?", "Is there a region where normal tissue regeneration appears impaired or where differentiation of progenitor cells seems inhibited?", "Does the image show a region where normal epithelial cells appear to be replaced, potentially compromising barrier integrity?"]}}, "autopsy": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image depict a procedure that typically lasts between 2 and 4 hours?", "Can you identify evidence of a process where 10 to 30 samples might be collected?", "Is there visual documentation of measurements such as organ weights, body length, or wound dimensions being recorded?", "Does the setting appear to be maintained at a temperature between 16 and 20 degrees Celsius?", "Is there any indication that a structured written report, typically 3 to 10 pages long, is being prepared?", "Can you see documentation or evidence of gross findings, microscopic examination, toxicology analysis, or photographic recording?", "Is there any indication that tissue samples weighing between 0.5 and 5 grams each are being collected?", "Does the image suggest that approximately 20 to 50 photographs are being taken as part of the process?", "Is there evidence of a report organized into sections such as clinical history, external and internal examination, and conclusions?", "Can you infer that the procedure is occurring within 6 to 48 hours after death?"], "relational": ["Does the image show an examination that includes all major organ systems such as the cardiovascular or nervous system?", "Are there visible assessments of structures like the heart, lungs, or brain?", "Can you identify exploration of body regions such as the thorax or abdomen?", "Is there evidence of sampling different tissue types, for example, parenchymal or muscle tissue?", "Does the image suggest an investigation aimed at determining cause of death or identifying disease processes?", "Are any bodily cavities, such as the cranial or abdominal cavity, visibly opened for examination?", "Can you see evaluation of anatomical connections like vascular pathways or nerve tracts?", "Is there removal of organs, tissue samples, fluids, or bone sections for further analysis?", "Does the image indicate investigation at multiple anatomical levels, such as both gross and tissue level?", "Are anatomical relationships such as organ position or structural integrity being documented or assessed?"], "contexual_behavior": ["Does the image suggest that enhanced biosafety measures are being used, possibly indicating a response to an infectious disease outbreak?", "Can you identify visual cues that might indicate rapid identification of a novel pathogen is being prioritized?", "Is there evidence of advanced tissue decomposition that could obscure anatomical or histological features, potentially reducing diagnostic yield?", "Does the image show signs of autolysis or putrefaction that might result from a prolonged postmortem interval?", "Are there visual indications of direct examination of affected tissues that could provide insight into disease mechanisms during an emerging epidemic?", "Can you see features that might limit the detection of subtle metabolic disorders, such as evidence of rapid death where biochemical changes are not morphologically apparent?", "Does the scene suggest that data collection for public health surveillance during a pandemic is being performed, such as documentation of mortality patterns or pathogen characteristics?", "Are there signs of severe trauma or disfigurement that could complicate identification of anatomical landmarks and determination of cause of death?", "Is there evidence of tissue changes or atypical disease progression that might be associated with treatment using novel therapies?", "Can you identify any hidden structural or functional abnormalities that could help explain an unexplained sudden death?", "Are there visual cues suggesting that legal or cultural restrictions are influencing the procedure, such as limited scope or regional variation in practice?", "Does the image show severely compromised tissue integrity or organ structure, as might be seen in advanced decomposition or mummification, potentially reducing the amount of functional information available?", "Are there patterns of organ failure visible that could help distinguish between deaths due to chronic versus acute diseases?", "Is there evidence that tissue samples are being preserved for molecular or genetic analysis, possibly for investigation of genetic diseases?", "Do you see signs that prolonged refrigeration may have occurred, which could limit the detection of infectious agents due to decreased microbial viability or nucleic acid integrity?", "Are there pathological changes or toxicological evidence present that might indicate occupational or environmental exposures as a cause of death?"], "functions": ["Does the image depict a procedure aimed at determining the cause of death through systematic examination?", "Is there evidence of a process that documents disease or provides information for legal or educational purposes?", "Can you identify activities focused on examining internal organs for pathological findings?", "Does the scene suggest the identification of infections, malignancies, or chronic conditions that may not have been diagnosed before death?", "Is there direct visualization or sampling of tissues for histological analysis to reveal organ pathology?", "Can you see indications of uncovering hidden diseases or abnormalities that might have been missed during life?", "Does the image show assessment of therapeutic outcomes or identification of complications related to medical treatments?", "Is there any evidence of collecting data that could contribute to public health surveillance, such as identifying mortality trends or emerging diseases?", "Can you observe procedures that might confirm diagnoses or trace sources of infection during an outbreak investigation?", "Is there collection of tissue samples or clinical data that could be used for scientific research?", "Does the image suggest activities aimed at detecting diagnostic errors or evaluating the accuracy of clinical care for quality assurance purposes?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the sample appear to have 20% to over 80% of cells exhibiting a specific chromosomal loss?", "Can you detect decreased expression or haploinsufficiency of genes such as CBFB, CDH1, or CYLD in the sample?", "Is there a visible loss affecting the chromosomal band 16q22 or its subregion 16q22.1?"], "relational": ["Is there evidence of cell cycle checkpoints or DNA repair complexes in the depicted cells that could be responding to chromosomal abnormalities?", "Are there visual cues indicating the presence of hematopoietic cells or bone marrow tissue that could be affected by chromosomal loss?", "Is there any sign of larger chromosomal abnormalities, such as monosomy or unbalanced translocations, affecting the depicted tissues?"], "contexual_behavior": [], "functions": ["Is there evidence of altered apoptosis regulation or changes in cell survival, such as increased or decreased programmed cell death?", "Can you identify features suggestive of increased susceptibility to malignancies in the sample?", "Is there visual evidence of cell cycle dysregulation, such as abnormal mitotic figures or loss of cell cycle checkpoints?"]}}, "med pas": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears thicker than usual, possibly indicating inflammation or edema?", "Can you identify an area that seems thinner, which might suggest atrophy or degeneration?", "Does any region display a color change that could be due to hemorrhage or pigment deposition?", "Is there a part of the image that looks more opaque, potentially from protein accumulation or fibrosis?", "Can you see abnormal deposits that might be associated with metabolic disorders or amyloidosis?", "Is there evidence of increased cellularity, as might occur in neoplastic processes or hyperplasia?", "Do you observe swelling that could be related to increased vascular permeability or lymphatic obstruction?", "Is there a visible decrease in volume that could be attributed to tissue loss or chronic disease?", "Can you identify fluid accumulation that might result from edema or cyst formation?", "Are there signs of fibrotic changes, such as scarring or tissue stiffness, possibly due to chronic inflammation?", "Does any area appear less dense, which could indicate fat infiltration or cellular loss?", "Is there evidence of calcifications, suggesting dystrophic or metastatic calcification processes?", "Do you notice changes in tissue composition that might reflect metabolic alterations or abnormal infiltration?", "Is there infiltration by inflammatory cells, as might be seen in infection or autoimmune reactions?", "Can you see regions with increased protein content, possibly due to exudative processes or inflammation?", "Are there swollen areas that could be the result of acute inflammation, trauma, or fluid accumulation?", "Is there loss of structural integrity, which might be caused by necrosis or enzymatic degradation?", "Do you observe cystic spaces that could be associated with degenerative disease or congenital anomalies?", "Is there increased rigidity in any region, possibly due to fibrosis or calcification?", "Are there abnormal staining patterns present, which could indicate amyloidosis or deposition of abnormal substances?"], "properties": ["Does the image show an object that is square or rectangular in shape and appears white in color?", "Can you identify an item that looks soft and porous, possibly made of cotton or similar materials?", "Is there a structure present that seems lightweight and flexible, able to conform to body contours?", "Does the image contain an object that appears to have a high capacity for absorbing fluids?", "Can you see something that looks like it could be sterile and is typically packaged in multiples per box?", "Is there a visible item that is small in size, possibly between 5 cm x 5 cm and 10 cm x 10 cm?", "Does the image include an object whose thickness appears to be a few millimeters, perhaps between 2 and 6 mm?", "Can you identify something that might have a neutral pH if tested?", "Is there an object that seems to have low density and moderate tensile strength, maintaining its shape during use?", "Does the image show an item that could retain and hold significant amounts of moisture?", "Can you see a structure that would likely have negligible water content before use but could absorb fluids rapidly?", "Is there an object present that would not withstand high temperatures, indicating low to moderate thermal resistance?", "Does the image include something that could have a shelf life of several years if kept sealed?", "Can you identify an item that is highly permeable to fluids, allowing for rapid absorption?"], "relational": ["Does the image show a region located within the mediastinum of the thoracic cavity?", "Can you identify an area that is adjacent to both the lungs and the heart?", "Is there a structure positioned near the vertebral column within the thorax?", "Does the image contain tissues such as connective tissue, fat, or lymphatic tissue in a central thoracic location?", "Can you see blood vessels passing through a space between the lungs and heart?", "Is there an anatomical region that contains major vessels like the aorta or superior vena cava?", "Does the image show nerves such as the phrenic or vagus nerves traversing a central thoracic compartment?", "Can you identify an area that is in contact with the heart, esophagus, or trachea?", "Is there a space surrounded by mediastinal fascia, separating it from other thoracic compartments?", "Does the image display compartments such as the anterior, middle, posterior, or superior mediastinum?", "Can you see a region bounded anteriorly by the sternum and posteriorly by the vertebral column?", "Is there an area laterally bordered by the pleural cavities and inferiorly by the diaphragm?", "Does the image show a space associated with bones like the sternum or thoracic vertebrae?", "Can you identify a region within the thorax that is related to the diaphragm?"], "contexual_behavior": ["Is there a structure in the image that appears more active in the context of an acute infection or immune response?", "Can you identify an object that might show reduced function in the setting of chronic disease or prolonged inflammation?", "Does the image contain a feature that could be dysfunctional due to oxidative stress or signs of cellular damage?", "Is there evidence of a component modulating cytokine production or recruiting immune cells during inflammation?", "Can you see a structure that might have impaired activity in autoimmune conditions due to immune dysregulation?", "Is there an area where enhanced cell proliferation or extracellular matrix remodeling suggests active tissue repair?", "Does the image show a region where activity appears diminished, possibly due to aging or decreased immune responsiveness?", "Is there a feature that could be rapidly activated to contribute to immune defense during acute illness?", "Can you identify a structure that may have lost its normal function after exposure to toxins or cellular injury?", "Is there evidence of altered energy utilization or signaling pathways in response to metabolic stress?", "Does the image reveal a component with functional decline under hypoxic conditions or reduced oxygen availability?", "Can you see a region with increased inflammatory mediator release or immune cell recruitment during an allergic reaction?", "Is there a structure whose effectiveness might be decreased due to genetic mutations affecting its structure or regulation?", "Does the image suggest a component responding to hormonal changes by altering its function?", "Is there evidence of increased activity following injury, such as initiation of repair mechanisms or modulation of the local immune environment?"], "functions": ["Is there evidence in the image of a structure or system that supports or regulates physiological functions?", "Can you identify an entity that facilitates communication or coordination among different body systems?", "Does the image show a component involved in maintaining homeostasis, such as balancing temperature, pH, or fluid levels?", "Is there a visible feature that could be responsible for hormonal, neural, or metabolic regulation?", "Can you see evidence of monitoring, adjustment, or integration of signals to maintain optimal function?", "Does the image contain a structure that exchanges information or mediates responses to internal or external stimuli?", "Is there an indication of dynamic processes like feedback loops, adaptation, or response to environmental changes?", "Can you identify an object that might regulate enzyme activity, control substrate availability, or maintain energy balance?", "Does the image show a feature associated with activating defense mechanisms or supporting immune surveillance?", "Is there a structure that appears to maintain equilibrium or adjust physiological parameters within the internal environment?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a round or oval structure within the nucleus measuring between 1 and 5 micrometers in diameter?", "Does the frequency of these nuclear structures vary among cells, possibly depending on the underlying disease process?", "Is there typically one, but occasionally several, of these inclusions present within a single nucleus?"], "relational": ["Can you identify structures located inside the nuclear matrix?", "Are there nuclear features visible in tissues such as brain, liver, or epithelial tissue?", "Does the image display nuclear inclusions alongside cytoplasmic or nucleolar inclusions?"], "contexual_behavior": [], "functions": ["Does the image show a subnuclear structure that could be involved in compartmentalizing or regulating nuclear activities?", "Can you see a nuclear feature that could be involved in protein quality control by sequestering aberrant or misfolded proteins?", "Can you identify a nuclear feature that might modulate gene expression by sequestering transcription factors or altering chromatin organization?"]}}, "mucosa": {"yes_questions": {"contexual_properties": ["Is there a tissue layer that appears thickened, possibly indicating chronic inflammation or abnormal cell growth?", "Can you identify a structure that looks thinner than usual, which might suggest atrophy or malnutrition?", "Does any surface show a change in color that could be due to inflammation, ischemia, or pigment accumulation?", "Is there evidence of swelling or edema in a lining, possibly related to acute inflammation or an allergic reaction?", "Can you see any ulcers or breaks in a lining that might be associated with Crohn's disease or infection?", "Is there a surface that appears inflamed, suggesting infection, autoimmune disease, or irritation?", "Does any area show increased mucus production, which could be a response to allergy or chronic irritation?", "Is there a region that looks friable or easily damaged, possibly due to severe inflammation or neoplastic changes?", "Can you spot erosions or superficial defects in a lining, which might be caused by gastritis or chemical injury?", "Is there a loss of normal texture in a tissue layer, potentially indicating chronic disease or scarring?", "Does any area display abnormal cell growth, such as dysplasia or signs of malignancy?", "Is there a pale-appearing surface that could be due to anemia, ischemia, or shock?", "Can you identify a region that appears hyperemic or more red than usual, possibly from acute inflammation or trauma?", "Is there visible pus accumulation within a lining, suggesting abscess formation or purulent infection?", "Do you see signs of atrophy in a tissue layer, such as thinning, which might be related to chronic gastritis or aging?", "Are there nodules present on a surface, which could indicate granulomatous disease or neoplasm?", "Does any area show increased vascularity, possibly due to chronic inflammation or healing?", "Is there discoloration of a lining, such as yellowing or dark patches, that might result from jaundice or hemorrhage?", "Can you spot white patches on a surface, which could be due to leukoplakia or candidiasis?", "Is there a region that appears rough or irregular, possibly from chronic irritation, neoplastic transformation, or scarring?"], "properties": ["Is there a structure in the image that appears smooth and moist?", "Can you identify a region that displays a pink or reddish coloration due to high vascularity?", "Does the image show a tissue layer with a thickness between 0.5 and 4 millimeters?", "Is there an area that likely contains both epithelial and goblet cells?", "Can you see a surface that appears to have a large area, as might be found in the intestinal tract?", "Does the image include a region that would be expected to have a high water content, around 70\u201380% by weight?", "Is there a structure that could have a pH ranging from very acidic in the stomach to near-neutral in the oral or intestinal regions?", "Can you identify a tissue that is likely responsible for secreting approximately 1\u20131.5 liters of mucus per day?", "Does the image show a layer composed of epithelial cells, connective tissue, blood vessels, and mucus?", "Is there a region that would be expected to have a temperature close to core body temperature, around 36\u201337\u00b0C?", "Can you see a tissue whose density is likely between 1.04 and 1.06 g/cm\u00b3?", "Is there an area that would be expected to have low lipid content, around 2\u20135% by weight?", "Does the image include a structure with protein content estimated at 10\u201320% by weight?", "Can you identify a region where carbohydrate content is low, mainly present as glycoproteins?", "Is there a tissue layer that would allow high permeability to small molecules for absorption and secretion?", "Does the image show a region that is likely to regenerate rapidly, with complete epithelial turnover every 3\u20137 days?", "Can you see an area with high vascular density to support nutrient exchange and immune function?", "Is there a tissue layer that could have anywhere from one to several layers of epithelial cells?", "Does the image show a structure with moderate elasticity, allowing it to stretch and conform to underlying tissues?", "Can you identify a region where the moisture level appears high due to continuous mucus secretion?"], "relational": ["Does the image show a structure that is part of the digestive, respiratory, urinary, or reproductive system and contains an innermost layer lining the lumen?", "Can you identify an organ such as the stomach, intestine, esophagus, trachea, bladder, or uterus that contains a distinct internal lining?", "Is there a visible layer composed of tissues like epithelium, lamina propria, and a thin layer of smooth muscle near the lumen?", "Does the image display a layered wall where the innermost lining is directly superficial to a deeper submucosal region?", "Can you see a region containing cell types such as epithelial cells, goblet cells, immune cells, or smooth muscle cells near the lumen?", "Is there a lining present in anatomical structures such as the alimentary canal, respiratory tract, urinary tract, or reproductive tract?", "Does the image include regions like the oral cavity, nasal cavity, gastrointestinal tract, or genitourinary tract with a specialized internal surface?", "Can you identify a boundary between an innermost lining and adjacent layers such as the submucosa or muscularis externa in a hollow organ?", "Is there evidence of interaction between the luminal contents and a specialized lining, possibly involving immune cells or secretory glands?", "Does the organ wall in the image show an organization where the innermost layer is followed by submucosa, muscularis externa, and an outermost serosa or adventitia?"], "contexual_behavior": ["Does the image show a tissue layer that might increase secretion of protective mucus in response to irritation or exposure to harmful substances?", "Can you identify a structure that could exhibit reduced barrier function during infection due to disruption of epithelial integrity?", "Is there evidence of increased permeability in a tissue layer, possibly as a result of inflammation and cytokine activity?", "Does the image contain a region where nutrient absorption might be impaired due to damage from diseases like celiac disease or inflammatory bowel disease?", "Can you see a tissue that could enhance immune defense by increasing immune cell activity or secreting antimicrobial peptides in response to pathogens?", "Is there a structure that might show decreased regenerative capacity after injury, especially if chronic inflammation or severe damage is present?", "Does the image include a tissue layer whose absorption properties could change during fasting or feeding?", "Is there evidence of impaired ciliary movement in a lining, possibly associated with respiratory diseases such as chronic bronchitis?", "Can you identify a region where antigen presentation might be increased during an allergic reaction, perhaps through activation of dendritic cells?", "Does the image show a tissue that could reduce its secretion in the context of dehydration?", "Is there a structure that might fail to prevent pathogen entry if immune surveillance and barrier functions are compromised, as in immunodeficiency?", "Can you see evidence of increased mucus production in response to irritation from allergens, pollutants, or infections?", "Does the image show a tissue layer that may lose its protective function due to immune-mediated epithelial damage, as seen in autoimmune disorders?", "Is there a region where absorption rate might be altered due to chronic inflammation and tissue remodeling?", "Can you identify a tissue that could have decreased defense against toxins following chemical exposure and epithelial injury?", "Does the image contain a structure that might activate repair mechanisms and promote regeneration after ulceration?", "Is there evidence of reduced enzymatic activity in a tissue layer, possibly due to diseases like lactase deficiency or celiac disease?", "Can you see a region where permeability might be increased during an allergic response due to mast cell activation?", "Is there a tissue that could show impaired function as a result of medication side effects, such as injury from NSAIDs or chemotherapy?", "Does the image include a structure whose defense mechanisms might be altered during stress through modulation of immune responses and barrier function?"], "functions": ["Does the image show a tissue layer that provides protection, absorption, secretion, or sensation within an organ system?", "Is there a structure that forms an epithelial barrier and produces a protective mucus layer?", "Can you identify a region specialized for nutrient absorption, possibly containing microvilli or enterocytes?", "Does the image include a layer that houses immune cells or contributes to mucosal immunity?", "Is there evidence of goblet cells or mucous glands responsible for mucus production?", "Can you see a surface that appears hydrated or has a visible mucus layer for moisture retention?", "Is there a tissue that acts as a barrier against pathogens, possibly through tight junctions or antimicrobial agents?", "Does the image reveal sensory receptors or nerve endings embedded within a tissue layer?", "Is there a thin, permeable epithelial surface that could facilitate gas exchange or substance transport?", "Can you identify features suggesting tissue repair or regeneration, such as areas of cellular proliferation or resident stem cells?", "Does the image show structures involved in local immune responses, such as lymphoid tissue or sites of antigen presentation?", "Is there evidence of selective permeability or active transport across an epithelial layer in the image?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see a gland that contains both chief cells and oxyphil cells?", "Is there a gland with a density close to 1.05 grams per cubic centimeter?", "Is there a structure whose phosphorus concentration is roughly 20\u201330 mg per 100 g of tissue?"], "relational": ["Can you see any structures in proximity to the recurrent or superior laryngeal nerves?", "Can you identify structures with lymphatic drainage to the deep cervical or paratracheal lymph nodes?", "Can you identify small glands located near or on the posterior surface of the thyroid gland?"], "contexual_behavior": ["Can you identify an object that would suppress hormone release in response to elevated blood calcium (hypercalcemia)?", "Does the image show a gland that could fail to regulate calcium homeostasis in the context of chronic kidney disease?", "Is there an object that would increase hormone secretion to counteract decreased calcium uptake during chronic malabsorption?"], "functions": ["Does the image show a gland involved in stimulating bone resorption and releasing minerals into the bloodstream?", "Is there a structure that influences phosphate balance by promoting its excretion through the kidneys?", "Is there a gland visible that helps maintain neuromuscular function by regulating calcium necessary for nerve and muscle activity?"]}}, "test tube": {"yes_questions": {"contexual_properties": ["Is there an object in the image that appears discolored, possibly due to exposure to chemicals or heat?", "Can you identify a structure that shows residue buildup, suggesting incomplete cleaning or evaporation of solutions?", "Does the image contain an item with visible cracks, which could result from mechanical stress or rapid temperature changes?", "Is there an object whose weight might have changed after use because of remaining residues or evaporation?", "Can you see a structure that looks cloudy, potentially due to deposition of insoluble materials or surface etching?", "Does any object in the image show accumulation of precipitate from a chemical reaction?", "Is there a structure with altered transparency, possibly caused by internal deposits, scratches, or chemical reactions?", "Can you identify an item with stains that may have resulted from chemical reactions producing colored byproducts?", "Does the image show a structure that could experience changes in internal pressure during heating or gas evolution?", "Is there an object that appears etched, possibly due to exposure to corrosive substances like strong acids or bases?", "Can you see contents that have changed color, perhaps due to a chemical reaction, pH shift, or indicator use?", "Is there a structure whose contents are separated into layers, indicating the presence of immiscible liquids or phases?", "Does the image contain an object with contents that have increased in volume, possibly from gas evolution, heating, or addition of reagents?", "Can you identify a structure whose contents have decreased in volume, perhaps due to evaporation, sampling, or chemical consumption?", "Is there an object whose contents appear more viscous, possibly as a result of concentration, polymerization, or precipitation?"], "properties": ["Does the image show an object with a cylindrical shape and a rounded bottom?", "Can you identify a structure that appears transparent or clear?", "Is there an object present that could have a volume capacity between 5 mL and 50 mL?", "Can you see something with a length likely between 75 mm and 150 mm?", "Is there a structure with a diameter in the range of 10 mm to 20 mm?", "Does the image contain an object that might be made from borosilicate glass, polypropylene, or polystyrene?", "Can you identify an object with a wall thickness of about 1 mm to 2 mm?", "Is there a structure that could weigh between 10 grams and 20 grams when empty?", "Does the image show an object with a smooth, flared rim?", "Can you see a structure with a labeling area approximately 20 mm by 40 mm?", "Is there an object that could withstand temperatures up to 500\u00b0C if made from borosilicate glass?", "Can you identify a structure that might exhibit high resistance to chemical corrosion?", "Does the image contain an object that could tolerate internal pressures up to about 1 atmosphere?", "Is there a structure whose melting point might be around 820\u00b0C if made from borosilicate glass?"], "relational": ["Does the image show an object commonly used in clinical chemistry or hematology procedures?", "Can you identify a container that might hold blood samples or reagents?", "Is there a vessel present that could contain culture media for microbiology?", "Does the image include an item that is typically supported by a rack or holder designed for cylindrical glassware?", "Can you see any racks, holders, or clamps that are used to support cylindrical laboratory containers?", "Is there a structure that could be placed in a centrifuge for sedimentation or separation by centrifugal force?", "Does the image show a process such as sample collection, mixing, incubation, or centrifugation involving a small cylindrical vessel?", "Can you identify glassware that is structurally similar to a culture tube or centrifuge tube?", "Is there a container with a closure such as a rubber stopper, screw cap, or plastic cap?", "Does the image show a device like a needle, syringe, or transfer pipette being used to transfer a specimen into a small cylindrical container?", "Is there a vessel that might contain anatomical samples such as blood, urine, or saliva?"], "contexual_behavior": ["Is there an object in the image whose ability to contain biological reactions could be compromised if exposed to extreme temperatures?", "Can you identify a vessel whose sterility might be affected by improper sealing or exposure to a non-sterile environment?", "Is there a container present that could have its function as a reaction vessel impaired by residual chemicals from previous uses?", "Does the image show an item whose capacity to support cell culture would decrease if its surface integrity were compromised by poor storage conditions?", "Is there a vessel in the image that could fail to preserve sample integrity if exposed to prolonged light, especially for photosensitive contents?", "Can you see an object whose role in separating blood components would depend on the speed of centrifugation, affecting the formation of distinct layers?", "Is there a container whose effectiveness in preventing evaporation might be reduced in a low humidity environment, leading to sample loss?", "Does the image include a vessel whose efficiency in mixing samples could be hindered by high viscosity solutions?", "Is there an object present whose ability to support enzymatic reactions would decrease if the pH level is not optimal for enzyme activity?", "Can you identify a vessel whose function in maintaining sample stability could be affected by rapid temperature changes, potentially causing condensation or denaturation?"], "functions": []}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a structure that appears to be about half the size of a typical nose?", "Is the density of the tissue similar to that of soft tissue, around 1.05\u20131.10 g/cm\u00b3?", "Is there evidence of cell types like epithelial cells, chondrocytes, osteocytes, fibroblasts, or endothelial cells in the depicted structure?"], "relational": ["Are bones like the nasal bone, maxilla, or ethmoid bone visible in the exposed area?", "Can you identify a connection between the exposed nasal region and the upper respiratory tract, specifically the nasopharynx?", "Can you see structures such as the nasal conchae or meatuses within a single nasal cavity?"], "contexual_behavior": [], "functions": ["Does the image suggest a change that might impair the sense of smell by affecting the olfactory region or its airflow?", "Is there evidence of a procedure that could disrupt the continuity of the nasal passages, potentially causing airflow obstruction or turbulence?", "Does the image show a loss of mucosal surface or barriers that would reduce the nasal cavity's filtration and humidification functions?"]}}, "section of mucosa": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears thickened, possibly as a result of chronic irritation or hyperplasia?", "Can you identify an area that looks thinned, which might suggest atrophy or the effects of chronic disease?", "Do you observe any region with abnormal color, such as redness, pallor, or dark discoloration, which could indicate inflammation, ischemia, hemorrhage, or pigment deposition?", "Is there evidence of ulceration, such as a break in the surface lining, which could be due to necrosis, infection, or persistent injury?", "Can you see swelling or puffiness in any area, suggesting edema from increased vascular permeability or inflammation?", "Is there a region that appears inflamed, possibly due to infection, autoimmune reaction, or chemical irritation?", "Do you notice areas with prominent blood vessels or increased vascularity, which might be associated with active inflammation, healing, or neoplastic changes?", "Is there a visible superficial defect or erosion, possibly resulting from injury, chemical damage, or infection?", "Can you identify a region that looks atrophic, potentially due to chronic inflammation, aging, or nutritional deficiency?", "Do you see any accumulation of mucus, which could be a response to irritation, infection, or increased secretion by goblet cells?", "Is there a part of the structure showing increased cellular infiltration, as might occur during an inflammatory or immune response?", "Does any area appear friable or easily disrupted, which could be a sign of inflammation, ulceration, or severe infection?", "Are there nodular formations present, possibly resulting from granulomatous inflammation, neoplastic processes, or chronic infection?", "Can you observe changes in texture, such as firmness or irregularity, which might be due to fibrosis, edema, or epithelial alterations?", "Is there evidence of hyperplasia, such as thickened or proliferative regions, possibly in response to chronic irritation, hormonal stimulation, or regeneration?", "Do you see loss of normal structural organization, which could result from ulceration, necrosis, or severe inflammation?", "Is there any abnormal secretion visible, which might be associated with infection, inflammation, or neoplastic transformation?", "Does any area appear unusually pale, suggesting anemia, ischemia, or reduced blood flow?", "Are there signs of hemorrhage, such as localized bleeding or red spots, which could follow trauma, vascular injury, or coagulation disorders?", "Can you identify regions that might have increased permeability, as indicated by swelling or exudate, possibly due to acute inflammation, allergic reaction, or tissue injury?"], "properties": ["Does the image show a tissue layer with a thickness that could range from half a millimeter to several millimeters?", "Is there a structure present that appears pink or reddish, possibly due to underlying blood vessels?", "Can you identify an area that covers several square centimeters in the sampled tissue?", "Does the image contain a region that looks soft, moist, and smooth in texture?", "Is there evidence of cells such as epithelial cells, goblet cells, immune cells, or fibroblasts in the tissue?", "Can you see a tissue that might have a high water content, making up most of its weight?", "Is there a region that could have a pH close to neutral, between 6.5 and 7.5?", "Does the image show a sample that might weigh from a few milligrams to grams, depending on its size?", "Can you identify a structure composed of an epithelial layer, an underlying lamina propria, and possibly a thin muscular layer?", "Is there a tissue area that could have a density similar to 1.05 grams per cubic centimeter?", "Does the image show a region likely to be at or near core body temperature, around 36.5 to 37.5 degrees Celsius?", "Is there a structure that would be expected to have low lipid content, less than 5% of its dry weight?", "Can you see a tissue that might contain 15 to 25 percent protein by dry weight?", "Is there an area that could have a carbohydrate content of about 1 to 5 percent of its dry weight?", "Does the tissue display an irregular, undulating surface, possibly due to folds or villi?", "Is there a layer where the epithelial thickness could range from 20 to 200 micrometers?", "Can you identify connective tissue that forms a significant portion of the sample, especially in the lamina propria?", "Is there evidence of glandular structures, ranging from a few to several dozen per square millimeter?", "Does the image show a region with high vascular density, including many capillaries and small blood vessels?", "Is there a tissue area that might contain a moderate amount of elastic fibers, contributing to flexibility and resilience?"], "relational": ["Does the image show a tissue layer that could be part of the digestive, respiratory, or genitourinary system?", "Is there a structure present that might belong to the stomach, intestine, esophagus, nasal cavity, or bladder?", "Can you identify a layer that is adjacent to the submucosa or muscularis mucosae?", "Does the image contain cells such as epithelial cells, goblet cells, immune cells, or enteroendocrine cells?", "Is there evidence of glands, capillaries, lymphatic vessels, or nerve endings supported by a tissue layer?", "Can you see a region that could be part of the oral cavity, gastrointestinal tract, respiratory tract, or urogenital tract?", "Is there a layer that lies superficial to the submucosa and is separated from it by another thin muscle layer?", "Does the image show mucous glands, gastric glands, or intestinal glands within a tissue section?", "Are there visible capillaries, arterioles, or venules supplying a particular tissue layer?", "Can you identify autonomic nerves, sensory nerve endings, or a submucosal plexus innervating a tissue region?"], "contexual_behavior": ["Does the image show a tissue that might increase mucus secretion in response to irritation or inflammation?", "Is there a structure present that could have reduced barrier function against pathogens due to injury or epithelial damage?", "Can you identify an area where nutrient absorption might be impaired by inflammation or infection?", "Does the image contain a region that could enhance immune defense activity during antigen exposure or immune stimulation?", "Is there evidence of tissue with decreased regenerative capacity, possibly due to chronic inflammation or aging?", "Can you see a structure that might have increased permeability to allergens during an allergic reaction or inflammation?", "Does the image show a tissue that fails to protect underlying layers when epithelial integrity is compromised or ulceration is present?", "Is there a region where secretion of mucus or antimicrobial peptides could be increased in response to infection?", "Can you identify an area where ciliary movement might be reduced due to toxic exposure such as cigarette smoke?", "Does the image show a tissue that could increase electrolyte transport during dehydration to maintain fluid balance?", "Is there a region where enzymatic activity might be diminished in the context of chronic inflammation or enzyme deficiency?", "Can you see evidence of increased antigen presentation during immune activation or infection?", "Is there a structure that might have decreased lubricating function in a dry environment or with reduced mucus production?", "Does the image show a tissue that could fail to maintain pH balance during metabolic disturbances such as acidosis?", "Is there an area where absorption efficiency might be altered after surgical intervention due to changes in surface area?"], "functions": ["Does the image show a structure that provides protection, secretion, absorption, or immune defense within an organ?", "Can you identify a layer that acts as a physical and biochemical barrier against pathogens or mechanical injury?", "Is there evidence of a tissue that releases mucus or other substances from specialized epithelial cells?", "Does the image contain a region that could allow nutrients, water, or electrolytes to be absorbed?", "Can you see a structure that might contain immune cells or produce antimicrobial peptides?", "Is there a visible layer where tight junctions between epithelial cells or a mucus layer might be present?", "Does the image show a tissue that could contain sensory receptors or nerve endings for sensing environmental changes?", "Can you identify a region that helps retain moisture on the epithelial surface through mucus secretion?", "Is there a structure that appears to regulate the passage of substances via selective permeability or mucus composition?", "Does the image suggest the presence of a tissue involved in local inflammatory responses, such as recruiting immune cells or releasing cytokines upon injury or infection?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see something with a volume of about 6.5 to 7 milliliters in adult humans?", "Does the image include something with a neutral pH, between 7.0 and 7.4?", "Can you identify an object in adult humans with a diameter of about 24 millimeters?"], "relational": ["Does the image display components like the sclera, iris, choroid, or vitreous body?", "Can you identify anatomical features such as the cornea, lens, or retina?", "Is there evidence of neural, connective, epithelial, or vascular tissue within any dissected structure?"], "contexual_behavior": ["Does the image include a specimen that may have lost its ability to generate electrical signals after prolonged storage?", "Does the image show a specimen that could recover functional activity after reoxygenation following an anoxic period?", "Does the image contain a sample where synaptic transmission could be diminished following mechanical injury?"], "functions": ["Does the image contain tissue that could be used to investigate synaptic activity within the retina or optic nerve?", "Is there a structure present that would enable analysis of visual transduction or adaptation mechanisms?", "Does the image show a specimen that could be used for direct examination of ocular structure and function in experimental analysis?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": ["Can you see any abnormal curvature that might indicate clubbing or congenital deformities?", "Are there calluses visible, possibly resulting from repeated friction or manual labor?", "Do any areas appear thinner than normal, which could be due to muscle wasting or peripheral neuropathy?"], "properties": [], "relational": ["Can you identify elements located within the anatomical regions of the hand or foot?", "Are tissues such as bone, muscle, tendon, ligament, nerve, blood vessel, or skin present in the structures you observe?", "Is there evidence of joints connecting certain structures to the hand or foot, such as metacarpophalangeal or metatarsophalangeal joints?"], "contexual_behavior": [], "functions": ["Can you see a feature that contributes to stabilization or weight distribution, especially during movement or support?", "Is there a structure in the image that enables grasping or manipulation of objects?", "Is there a structure used for gesturing, forming signs, or nonverbal communication?"]}}, "whipples disease": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any evidence of disease affecting both the digestive and lymphatic systems?", "Can you identify abnormalities in the intestinal mucosa or lymphoid tissue?", "Is there visible infiltration in structures such as the lamina propria or mesenteric lymph nodes?", "Does the image include regions of the gastrointestinal tract like the duodenum, jejunum, or ileum with signs of pathology?", "Are there any changes in mesenteric lymph nodes or intestinal lymphatics apparent in the image?", "Can you see involvement of organs outside the digestive tract, such as the heart, joints, brain, or eyes?", "Is there evidence of malabsorption or infiltration in the small intestine, particularly in the jejunum or duodenum?", "Does the image suggest structural alterations in the gastrointestinal, lymphatic, musculoskeletal, or nervous systems?", "Are there any abnormalities involving the meninges, brain parenchyma, or cranial nerves?", "Can you detect the presence of foamy macrophages or PAS-positive granules within affected tissues?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a condition causing malabsorption and weight loss affecting multiple organ systems?", "Can you identify signs of intestinal mucosa damage or villous atrophy that could impair nutrient absorption?", "Is there visual evidence of chronic diarrhea, abdominal pain, or steatorrhea indicating disrupted gastrointestinal function?", "Does the image suggest accumulation of bacteria within macrophages or features of impaired immune clearance?", "Are there indications of reduced enzymatic breakdown or impaired absorption of nutrients in the small intestine?", "Can you see features consistent with mucosal infiltration or lymphatic obstruction compromising small intestine function?", "Does the image reveal signs of metabolic disturbances such as electrolyte imbalance or protein-energy malnutrition?", "Is there evidence of fat or carbohydrate malabsorption, such as steatorrhea or unexplained weight loss?", "Can you identify features of impaired lymphatic function, such as lymphatic obstruction or chylous ascites?", "Does the image suggest chronic infection or systemic inflammation due to persistent immune activation?", "Are there visual clues indicating neurological deficits, such as ataxia or oculomotor dysfunction?", "Can you see signs of joint dysfunction, including migratory arthralgia or chronic arthritis?"]}, "no_questions": {"contexual_properties": ["Do you observe changes in cell ion content, such as features suggestive of altered sodium, potassium, or calcium levels?", "Do you observe plasma membrane blebbing that might indicate cytoskeletal disruption or osmotic imbalance?", "Is there dilation of the endoplasmic reticulum, suggesting swelling of ER cisternae from osmotic changes?"], "properties": [], "relational": ["Is there evidence of interaction between affected cells and components of the immune, circulatory, or lymphatic systems?", "Do any cells in the image seem to be influencing their neighbors through local signaling or inflammatory responses?", "Can you identify any structural changes in the plasma membrane, mitochondria, or endoplasmic reticulum within the depicted cells?"], "contexual_behavior": ["Do any cells appear to regain normal structure or function after restoration of favorable conditions, indicating recovery and reestablishment of homeostasis?", "Can you identify cellular features suggesting impaired energy production, such as signs of hypoxia or mitochondrial dysfunction?", "Can you identify signs of impaired waste removal, such as accumulation of debris or lysosomal dysfunction during toxic exposure?"], "functions": ["Does the image show cells exhibiting swelling or changes in membrane structure?", "Can you observe features that suggest activation of repair mechanisms, such as restoration of membrane integrity or removal of damaged proteins?", "Do any cells display signs of disrupted ion homeostasis, such as sodium and water influx or potassium efflux?"]}}, "placental abruption": {"yes_questions": {"contexual_properties": ["Is there evidence of an acute event in the third trimester characterized by significant blood loss?", "Can you observe a structure that appears reduced in size due to detachment or infarction?", "Does the image show a change in tissue texture that could result from hemorrhage or clot formation?", "Is there visible discoloration of a tissue that might be caused by blood accumulation or hematoma?", "Can you identify clotted blood accumulating behind a tissue at the site of separation from the uterine wall?", "Is there a structure that appears to have decreased weight or mass, possibly due to tissue loss or infarction?", "Does the image suggest impaired oxygen exchange to the fetus, such as signs of hypoxemia?", "Can you see any indication of acute injury that might be associated with elevated maternal serum markers like alpha-fetoprotein?", "Is there a tissue that appears separated from the uterine wall upon clinical or pathological examination?", "Does the image show increased tone or firmness of the uterus, possibly due to acute hemorrhage or myometrial irritation?", "Can you observe a hematoma forming between a tissue and the uterine wall, particularly in the retroplacental space?", "Is there any discoloration of the amniotic fluid that could result from fetal bleeding or the presence of meconium?", "Does the image indicate reduced perfusion of a tissue due to vascular disruption during separation?", "Can you see signs of edema in a tissue, possibly resulting from inflammation or vascular leakage?", "Are there abnormal ultrasound findings, such as retroplacental hematoma or thickening, visible in the image after an acute event?"], "properties": ["Does the image show evidence of acute onset symptoms occurring during the second or third trimester of pregnancy?", "Can you identify a situation where blood loss appears to be between 500 and 2000 milliliters, possibly indicating severity?", "Is there visual or clinical evidence suggesting grading of a condition as mild, moderate, or severe based on findings?", "Does the image suggest decreased fibrinogen levels, such as findings consistent with coagulopathy?", "Can you observe signs of maternal hypotension or normal blood pressure in the context of significant blood loss?", "Is there evidence of reduced hematocrit, possibly below 30%, due to hemorrhage?", "Does the image indicate the presence of concealed bleeding, or is the bleeding revealed and externally visible?", "Can you determine if the gestational age falls between 24 and 36 weeks, suggesting a preterm complication?", "Is there any indication of thrombocytopenia, such as a platelet count below 150,000 per microliter, or are platelet levels normal?", "Does the image show blood that appears dark, clotted, or mixed with amniotic fluid?"], "relational": ["Does the image show evidence of premature separation between a structure supplying nutrients to the fetus and the wall of the uterus?", "Can you identify any disruption at the interface between maternal and fetal tissues?", "Is there a visible detachment involving the region where the placenta normally attaches to the uterine wall?", "Does the image reveal abnormalities affecting fetal blood vessels or the umbilical cord?", "Can you see any involvement of the amniotic or chorionic membranes in the area of separation?", "Is there evidence of disruption in the decidua basalis or myometrium?", "Does the image show signs of compromised maternal blood vessels, such as spiral arteries or decidual vessels?", "Can you observe any structural changes impacting the fetal circulatory system?", "Is there a visible disturbance in the maternal-fetal interface or decidual layer?", "Does the image suggest partial or complete loss of contact between the placenta and its implantation site?"], "contexual_behavior": ["Is there evidence of a condition where separation between the maternal and fetal blood supply could lead to reduced oxygen delivery to the fetus?", "Does the image suggest impaired transfer of nutrients from mother to fetus due to placental detachment?", "Can you identify signs of maternal blood loss that might result from vascular disruption at the maternal-fetal interface?", "Is there visual evidence of placental tissue damage that could disrupt hormone exchange between mother and fetus?", "Does the image indicate a scenario where fetal waste removal may be compromised due to limited transfer to maternal circulation?", "Are there features suggesting that trauma has caused abrupt detachment of the placenta, potentially altering its barrier function?", "Can you observe any indications that impaired placental function might be compromising fetal growth?", "Is there evidence that acute fetal hypoxia could be affecting fetal heart rate variability in this scenario?", "Does the image show tissue injury at the maternal-fetal interface that could impair immune regulation?", "Are there signs that loss of placental function may be increasing the risk of preterm labor, possibly due to inflammation?", "Can you see features suggesting impaired regulation of water and electrolytes between mother and fetus, indicating fluid balance disturbance?", "Is there evidence of placental necrosis or loss of placental mass that could result in hormone deficiency?", "Does the image suggest that the placenta's capacity to filter toxins from fetal circulation is impaired due to separation?", "Are there indications that the placental barrier's integrity is compromised, potentially increasing the risk of fetal exposure to maternal infections?", "Can you identify features that might indicate impaired gas exchange and acid-base imbalance due to placental insufficiency?"], "functions": ["Does the image show evidence of impaired placental function that could compromise fetal oxygenation or cause maternal hemorrhage?", "Is there a visual indication of disrupted maternal-fetal blood exchange leading to decreased oxygen delivery to the fetus?", "Can you identify features suggesting reduced nutrient transfer from mother to fetus due to separation of the placenta from the uterine wall?", "Does the image reveal signs of impaired elimination of fetal metabolic waste products?", "Is there evidence of disrupted maternal-fetal circulation, such as reduced uteroplacental blood flow or signs of fetal compromise?", "Can you see indications of altered hormone exchange or impaired endocrine function at the placental interface?", "Does the image suggest increased risk of preterm labor, such as signs of uterine contractions or irritability?", "Is there visual evidence of fetal growth restriction or intrauterine growth retardation due to limited supply of nutrients and oxygen?", "Can you identify signs of maternal bleeding or coagulopathy that may indicate impaired maternal hemostasis?", "Does the image show features consistent with fetal distress, such as hypoxia or acidosis?", "Are there indications of physiological changes in the uterus, such as increased tone, tenderness, or contractions?", "Can you see evidence of compromised placental barrier function, suggesting increased fetal vulnerability to harmful substances or pathogens?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a space that connects to the nasal cavity through an opening in the middle meatus?", "Can you identify a cavity adjacent to the nasal cavity, orbit, or upper teeth roots?", "Is there a paranasal sinus visible that is related to the frontal, ethmoid, or sphenoid sinuses?"], "contexual_behavior": [], "functions": ["Is there evidence of a cavity that participates in regulating pressure within the nasal cavity by allowing air exchange?", "Can you identify a feature that plays a role in mucociliary clearance and respiratory protection?", "Is there a visible ostium that could facilitate air exchange and pressure equilibrium with the atmosphere?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the specimen appear to be contained within the ocular system or nervous system?", "Can you see distinct regions such as the anterior chamber, posterior chamber, vitreous body, or optic disc?", "Does the image show a structure that is part of the visual system?"], "contexual_behavior": ["Does the image display any signs of impaired retinal organization that could result from inadequate fixation protocols?", "Does the tissue appear to have lost the ability to retain in situ hybridization signals, potentially due to nucleic acid degradation from overexposure to fixatives?", "Can you see evidence that synaptic architecture is better preserved in areas likely subjected to rapid chemical processing?"], "functions": ["Can you see spatial organization or mapping of different cell types and tissue layers in the specimen?", "Are there signs of biological processes such as apoptosis, cell proliferation, or tissue remodeling within the ocular tissue?", "Are there visual indicators of immune cell infiltration or inflammatory markers within the eye tissue?"]}}, "section": {"yes_questions": {"contexual_properties": ["Does the image show a tissue sample that appears thicker, possibly due to microtome settings or incomplete embedding?", "Is there a sample that looks thinner, which could result from lower microtome thickness or overprocessing?", "Can you identify a tissue area where the color varies, suggesting different stains or changes in tissue composition?", "Does the sample display regions with increased cellularity, as might be seen in hyperplasia, neoplasia, or inflammation?", "Is there an area with decreased cellularity, which could indicate atrophy, necrosis, or degeneration?", "Can you observe any abnormal staining patterns that might result from altered staining protocols or pathological changes?", "Is there evidence of fragmentation in the tissue, possibly due to brittleness, poor fixation, or excessive thinness?", "Does the sample show increased fibrous tissue, as might occur in chronic inflammation or tissue repair?", "Can you see signs of fluid accumulation, such as edema, within the tissue?", "Is there visible deposition of substances like amyloid, hemosiderin, or lipids, suggesting diseases such as amyloidosis or lipidosis?", "Does the sample contain areas of necrosis, possibly due to cell death from injury, ischemia, or toxins?", "Is there a region that appears more transparent, which could be due to thinness, poor staining, or increased extracellular matrix?", "Can you identify a part of the sample that looks opaque, potentially from increased thickness, heavy staining, or dense fibrotic material?", "Does the tissue architecture appear altered, as might be seen in neoplasia, inflammation, or remodeling?", "Is there evidence of increased immune cell infiltration, suggesting inflammation from infection or autoimmune disease?", "Can you observe any loss of structural integrity, which could result from poor fixation, overprocessing, or necrosis?", "Are there areas showing calcification, possibly indicating dystrophic or metastatic calcification?", "Does the sample appear more eosinophilic, which might reflect increased protein content or cell injury?", "Is there a region that appears more basophilic, suggesting increased nucleic acid content or ribosomal activity?", "Can you see abnormal cell morphology, as might occur in dysplasia, malignancy, or viral infection?"], "properties": ["Is there an object in the image that measures between 1 and 5 centimeters in length?", "Can you identify a structure whose width appears to be within the range of 0.5 to 2 centimeters?", "Does the image show a thin object that could be 3 to 10 micrometers thick, as used in histological analysis?", "Is there a rectangular or oval-shaped area present, reflecting a typical cutting method?", "Can you see a region whose area might fall between 0.5 and 10 square centimeters?", "Is there an object whose estimated volume could be between 1 and 100 cubic millimeters, based on its area and thickness?", "Does the image contain a structure that appears pink, purple, or blue, possibly due to staining under light microscopy?", "Can you identify an object that might have a density close to 1.0 to 1.1 grams per cubic centimeter, as expected for biological tissue?", "Is there a region that could be composed of cellular and extracellular components such as proteins, lipids, carbohydrates, and water?", "Does the surface of any structure appear smooth or display microstructural features typical of prepared tissue samples?", "Can you see an object that might have a refractive index in the range of 1.35 to 1.55, as seen in tissue sections?", "Is there evidence of a structure with high water content, possibly comprising 60% to 80% of its mass?", "Can you identify a region that could contain 10% to 20% protein by mass, as is typical for tissue samples?", "Does the image show an area that might have a lipid content between 2% and 30%, depending on tissue type?", "Is there a structure that could contain 1% to 5% carbohydrate by mass?", "Can you observe differences in staining intensity, ranging from weak to strong, across any regions in the image?", "Is there an object that appears to be maintained at room temperature, approximately 20 to 25 degrees Celsius, during analysis?", "Can you identify a region that might have a pH between 6.8 and 7.4, as expected after typical tissue processing?"], "relational": ["Does the image display a specific slice or subdivision of an anatomical structure?", "Can you identify a portion that serves as a component of a larger organ or tissue?", "Is there a defined area where smaller parts such as cells, fibers, or microstructures are visible?", "Does the image show a region that maintains spatial or functional relationships with the entire structure?", "Can you see a portion containing different tissue types, such as epithelial, connective, muscle, or nervous tissue?", "Is there a visible boundary or landmark that could represent a plane of dissection or a natural demarcation?", "Are there adjacent regions or features that could be neighboring subdivisions or connective tissue within the same organ?", "Does the image include a subdivision that might be used in anatomical nomenclature, histology, or surgical classification?", "Can you identify an area that shares borders and appears functionally continuous with neighboring regions?", "Is there evidence that the displayed portion was created using a specific anatomical plane, such as sagittal, coronal, or transverse?"], "contexual_behavior": ["Is there evidence of localized injury in any tissue area, such as disrupted cellular integrity or altered architecture?", "Can you identify a region where metabolic activity might be impaired due to reduced blood supply or signs of hypoxia?", "Does the image show an area with increased cell proliferation or tissue repair, suggesting regenerative activity after damage?", "Is there a muscle region that appears to have reduced contractile function, possibly indicating fatigue or energy depletion?", "Can you see a brain area that might be experiencing abnormal signaling, as could occur during a seizure?", "Is there a section of the intestine that shows signs of inflammation, such as compromised mucosal integrity or reduced absorption?", "Does the lung tissue display features like filled alveolar spaces, which could indicate impaired gas exchange due to infection?", "Is there a heart region with evidence of cell death or scar tissue, suggesting reduced pumping efficiency after infarction?", "Can you identify a kidney area that may have decreased filtration, possibly due to acute injury to glomerular or tubular cells?", "Is there a liver region that appears to be increasing enzyme production, potentially in response to toxins?", "Does any skin area show loss of barrier function, such as disruption of the epidermal layer after trauma?", "Is there a bone region with signs of increased remodeling activity, as might be seen during fracture healing?", "Can you see a glandular tissue area where secretion appears altered, possibly due to hormonal regulation?", "Is there a spinal cord region that might have lost signal transmission, such as after compression or disruption of axonal pathways?", "Does the pancreas show any area with decreased insulin secretion, which could be associated with beta cell dysfunction in diabetes?"], "functions": ["Does the image show a thin slice or subdivision of tissue prepared for analysis?", "Can you identify a sample that allows detailed observation of cellular and structural organization within the tissue?", "Is there a visible area that reveals spatial relationships among cells and extracellular components?", "Does the image contain a sample suitable for microscopic examination of tissue morphology?", "Can you see a region that could be used for histopathological evaluation or disease identification?", "Is there evidence of cellular abnormalities or pathological changes within the tissue sample?", "Does the image allow for the assessment of cell interactions, proliferation, or differentiation within a defined tissue context?"]}, "no_questions": {"contexual_properties": ["Do any glands show signs of fibrosis, as might be seen in chronic inflammation or after tissue injury?", "Can you identify regions of glandular hyperplasia, possibly due to chronic irritation or hormonal influence?", "Is there an increased number of mitotic figures within glandular structures, indicating rapid proliferation or malignancy?"], "properties": ["Is the number of cells per gland consistent with several dozen to a few hundred?", "Can you see epithelial cells that are cuboidal or columnar in shape lining these glandular structures?", "Do the cells within these structures display abundant cytoplasm containing secretory granules?"], "relational": ["Are there visible clusters of secretory epithelial cells, myoepithelial cells, or ductal cells?", "Do you see any anatomical features adjacent to connective tissue, blood vessels, or nerves?", "Can you see blood vessels such as arterioles, capillaries, or venules supplying a cluster of glandular cells?"], "contexual_behavior": ["Does the image show changes in the types or amounts of secreted products that might be due to exposure to environmental toxins?", "Can you identify a structure that appears hyperactive, possibly due to chronic hormonal or neural stimulation?", "Is there evidence that normal homeostasis is not maintained, which could be due to metabolic disease and disrupted regulatory pathways?"], "functions": ["Is there a region producing or releasing substances such as mucus, enzymes, hormones, or antimicrobial peptides?", "Is there evidence of fluid or electrolyte regulation within the tissue, possibly through secretion or absorption?", "Does the image contain a structure that helps maintain optimal moisture, pH, or nutrient levels within the tissue?"]}}, "pus": {"yes_questions": {"contexual_properties": ["Is there a substance in the image that appears thicker, possibly indicating a prolonged infection or dehydration?", "Can you observe a material whose color varies, suggesting differences in the type of infecting organism, presence of blood, or stage of inflammation?", "Is there evidence of a watery exudate that might indicate an early or acute infection?", "Does the image show an accumulation of fluid and cells that could increase in volume with an active inflammatory response?", "Can you identify an area where the volume of a discharge appears reduced, possibly due to resolution, drainage, or immune clearance?", "Is there a visible exudate that might be associated with a foul odor, suggesting anaerobic infection or tissue necrosis?", "Do you see a substance containing visible blood, which could indicate capillary damage or tissue injury at the site?", "Is there a greenish coloration present, possibly due to high neutrophil activity or association with Pseudomonas infection?", "Can you detect a yellowish discharge that might result from the accumulation of dead neutrophils and cellular debris?", "Is there a brownish tint to any exudate, suggesting the presence of degraded blood products or chronic infection?", "Does the image show a collection that could contain a high number of bacteria, indicating active or uncontrolled infection?", "Is there a thin, less viscous fluid present that might be due to dilution by serous fluid or an early stage of infection?", "Can you observe a discharge that may have increased protein content, potentially due to extensive tissue breakdown or high leukocyte turnover?", "Is there evidence of a material with abundant dead cells, reflecting an intense immune response or leukocyte apoptosis?", "Do you see signs that a substance might be more acidic, possibly due to intense bacterial metabolism or anaerobic infection?", "Is there an area where the exudate could be more alkaline, perhaps due to ammonia production by certain bacteria?", "Can you identify changes in the cellular makeup of a discharge, suggesting progression of infection or infiltration by different immune cells?", "Is there a large accumulation of fluid that could indicate abscess formation or impaired drainage?", "Does the image show a thickened material that might result from fluid evaporation at a wound or drainage site?", "Can you observe changes in the consistency of a discharge that might reflect shifts in cellular content, protein concentration, or fluid balance during infection progression?"], "properties": ["Does the image show a substance that appears yellow, green, or white?", "Is there a material with a thick, creamy, or viscous consistency present?", "Can you identify a fluid that might have a foul or unpleasant odor?", "Is there evidence of a substance with high water content, making up most of its volume?", "Does the image contain material that could be rich in neutrophils or macrophages?", "Is there a collection of fluid that might have a protein concentration between 3 and 6 g/dL?", "Can you see a substance that is likely to have low lipid content, less than 1%?", "Is there a fluid accumulation that could have a glucose level lower than that of blood?", "Does the image show a collection whose volume could range from a few milliliters to over a hundred milliliters?", "Is there a substance present that might have a density slightly higher than water, around 1.03 to 1.05 g/mL?", "Can you identify a material that is likely to be at or near body temperature?", "Does the image show a collection that could contain a high concentration of bacteria?", "Is there evidence of a fluid with a very high white blood cell count?", "Can you see a substance that might contain abundant dead cells or cellular debris?", "Is there a material present that could exhibit high viscosity due to its cellular and protein content?", "Does the image suggest the presence of a fluid with elevated levels of enzymes such as lysozyme or proteases?", "Is there a collection that might contain significant amounts of sodium, potassium, or chloride?", "Can you identify a substance that could have high concentrations of inflammatory mediators like cytokines or chemokines?"], "relational": ["Does the image show evidence of acute inflammation in tissues such as the skin, lungs, or mucous membranes?", "Can you identify a region that might contain neutrophils or dead macrophages?", "Is there a visible accumulation that could be associated with bacteria within tissue spaces or wounds?", "Does the image contain a localized collection within an abscess cavity?", "Can you see a structure that might be surrounded by an abscess wall or fibrous capsule?", "Is there an area that appears to be lined by epithelial tissue and contains cellular debris?", "Does the image show a feature that could represent a fistula, sinus tract, or surgical drain facilitating the removal of material from a tissue space?", "Can you identify a collection in subcutaneous tissue, the oral cavity, pleural cavity, or peritoneal cavity?", "Is there a region that suggests the presence of an infected wound resulting from an immune response to bacterial invasion?", "Does the image show a protein-rich fluid containing leukocytes and bacteria within a wound or tissue space?"], "contexual_behavior": ["Does the image show evidence of increased neutrophil response and bacterial lysis, suggesting an acute infection?", "Is there a sign of localized accumulation that could indicate inefficient drainage or a robust immune response?", "Can you identify features that might suggest reduced pus production, such as after antibiotic therapy or surgical debridement?", "Does the image reveal a viscous, dense accumulation that could be associated with chronic inflammation and high protein content?", "Is there visual evidence of wound healing that might be facilitated by drainage or debridement of infectious material?", "Can you see persistent accumulation that could be due to impaired phagocytosis or chronic infection, possibly in an immunocompromised individual?", "Does the image suggest slowed formation or minimal accumulation, as might be seen in immunosuppressed patients with low neutrophil counts?", "Is there a localized, encapsulated collection that could indicate abscess formation with tissue necrosis?", "Can you identify features suggesting the presence of a foreign body, ongoing inflammation, or persistent infection?", "Does the image show changes in the appearance of the accumulation that could correspond to different stages of infection, such as varying cellular or protein content?", "Is there evidence of neutrophilic inflammation that might be triggered by fungal pathogens?", "Does the image lack prominent accumulation, which could suggest a viral infection with minimal neutrophil activity?", "Can you see signs of impaired drainage, such as tissue fibrosis or chronic inflammation obstructing outflow?", "Is there evidence of poor wound healing or chronic wounds that might be associated with diabetes mellitus and increased accumulation?", "Does the image suggest impaired healing or persistent accumulation that could be due to poor circulation or ischemia?", "Can you identify features that might indicate effective immune modulation, such as reduced inflammation and resolution of infection?", "Is there a rapidly accumulating collection in deep tissue, possibly due to poor drainage and extensive tissue necrosis?", "Does the image suggest altered suppurative processes that could be related to autoimmune disease or sterile inflammation?", "Is there evidence of delayed healing or persistent accumulation that might be seen in malnourished individuals with impaired immunity?"], "functions": ["Does the image show evidence of a substance involved in collecting and removing dead cells or debris from an area of infection?", "Can you identify an accumulation that suggests the recruitment of neutrophils or other immune cells at a site of inflammation?", "Is there a visible feature that could indicate the containment or neutralization of invading microorganisms?", "Does the image display material that might be associated with the drainage of infected tissue or removal of pathogens?", "Can you see a localized collection that could be playing a role in isolating infection and facilitating tissue repair?", "Is there an area that appears to be clearing necrotic tissue or promoting the resolution of inflammation?", "Does the image include a structure that could represent a barrier preventing the spread of pathogens, such as an abscess?", "Can you identify a region where cellular debris and dead cells are being eliminated from infected tissues?", "Is there an accumulation that might act as an exudate mediating immune defense and tissue cleanup at a site of infection?", "Does the image show a medium where immune cells like neutrophils or macrophages are aggregating to target pathogens?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see any changes in the spleen or liver that might suggest involvement by a hematopoietic disorder?", "Does the image suggest spread of abnormal tissue along lymphatic vessels or into adjacent tissues?", "Does the image show signs of abnormal cell proliferation within lymphatic structures?"], "contexual_behavior": [], "functions": ["Can you identify a region where normal lymphoid tissue appears to be replaced or disrupted, potentially impairing immune responses?", "Is there visual evidence of abnormal lymphocyte activity, such as signs of malignant transformation or functional dysregulation?", "Does the image indicate impaired B cell function or reduced antibody production?"]}}}
[ { "answer": "x-ray barium study gastric polyp", "extracted_concepts": [ "gastric polyp", "barium study", "x-ray" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "gastric polyp", "barium study", "x-ray" ], "question": "does this image show x-ray barium study gastric polyp?" }, { "answer": "no", "extracted_concepts": [ "gastric polyp", "barium study", "appendix", "x-ray" ], "question": "does appendix show x-ray barium study gastric polyp?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "no", "extracted_concepts": [ "corpus luteum" ], "question": "is corpus luteum present?" }, { "answer": "stomach", "extracted_concepts": [ "stomach" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "stomach" ], "question": "is stomach present?" }, { "answer": "no", "extracted_concepts": [ "aorta" ], "question": "is aorta present?" }, { "answer": "gastrointestinal system", "extracted_concepts": [ "gastrointestinal system", "x-ray" ], "question": "where is this x-ray figure taken?" }, { "answer": "gastrointestinal", "extracted_concepts": [ "gastrointestinal" ], "question": "what is present?" }, { "answer": "stomach", "extracted_concepts": [ "stomach" ], "question": "what is present?" } ]	["gastric polyp", "corpus luteum", "aorta", "gastrointestinal", "barium study", "stomach", "gastrointestinal system", "appendix", "x-ray"]	{"gastric polyp": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a lesion in the image measuring between 0.5 and 2 centimeters in diameter?", "Can you identify a structure with a round, oval, or pedunculated shape?", "Does the image show a lesion that appears pink, red, or similar in color to the surrounding mucosa?", "Is there an object whose weight is likely less than 1 gram based on its size and appearance?", "Can you see a structure that might be composed of glandular epithelium and stroma?", "Is there a lesion that could contain foveolar epithelial cells or mucous cells?", "Does the image show a single lesion or are there multiple similar lesions present?", "Can you identify a structure with a smooth or lobulated surface texture?", "Is there evidence of mild to moderate vascularity, such as small blood vessels, within a lesion?", "Does the lesion appear to have increased mucin content, as might be seen in hyperplastic or fundic gland types?", "Is there a structure where the cells are likely to have a low mitotic index, except in areas that might appear dysplastic?", "Can you see features suggesting absent, low-grade, or possibly high-grade dysplasia within a lesion?", "Does the lesion appear to be slowly growing, based on its size and characteristics?", "Is there evidence of increased glandular density compared to the surrounding mucosa?", "Can you identify a structure with moderate stromal content?", "Does the tissue in the lesion appear to have a pH close to neutral, around 7.0?", "Is there a structure with low to moderate collagen content?", "Can you see a lesion where necrosis is absent or minimal?", "Is there evidence that the lipid content of the lesion is low?", "Does the lesion lack visible calcification, or is calcification rare or absent?"], "relational": ["Is there a lesion present within the gastrointestinal system?", "Can you identify a structure located in the mucosal layer of the stomach, particularly in the body or antrum?", "Does the image show an abnormality arising from the gastric mucosa?", "Is there a growth that appears continuous with the lining of the stomach?", "Can you see a structure that primarily affects the mucosa and possibly extends into the submucosa of the stomach wall?", "Is there a lesion involving the gastric epithelium and underlying lamina propria?", "Does the image show a mass adjacent to the gastric lumen or near the muscularis mucosae?", "Can you identify a structure in proximity to gastric glands?", "Is there an abnormality situated between the esophagus and the duodenum?", "Does the image contain a lesion composed of cells such as foveolar epithelial cells, glandular cells, or inflammatory cells?", "Can you see a structure in an area supplied by branches of the left or right gastric arteries?", "Is there an abnormality interacting with the mucus layer or muscularis mucosae of the stomach?"], "contexual_behavior": [], "functions": ["Does the image show an abnormal growth arising from the lining of the stomach?", "Can you identify a structure that disrupts the normal architecture of the gastric mucosa?", "Is there evidence of altered epithelial integrity within the stomach lining?", "Does the image reveal a lesion that could interfere with digestive processes by causing localized obstruction?", "Can you see a growth that might impede the passage of gastric contents and affect stomach motility?", "Is there a visible disruption of the protective barrier of the stomach lining?", "Does the image show signs of local inflammation, such as recruitment of inflammatory cells around a mucosal lesion?", "Can you identify an area that could serve as a site for abnormal cell growth, dysplasia, or neoplastic transformation within the gastric mucosa?", "Is there a lesion present that is unlikely to affect nutrient absorption, given that most absorption occurs in the small intestine?", "Does the image show a structure that might trigger local immune cell infiltration and inflammatory signaling in the stomach lining?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see a region that might be innervated by fibers from the superior mesenteric plexus?", "Does the image contain loops that could represent jejunal segments?", "Is there a structure that connects proximally to the duodenum and distally to the ileum?"], "contexual_behavior": [], "functions": ["Can you identify a region with highly folded mucosa and numerous villi that increase surface area?", "Is there evidence of coordinated smooth muscle contractions, such as peristalsis or segmentation, maintaining gut motility?", "Is there a region contributing to water and electrolyte absorption for fluid balance?"]}}, "corpus luteum": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify an object located within the ovary?", "Is there a structure surrounded by ovarian stroma or connective tissue?", "Does the image contain a region composed mainly of granulosa lutein cells or theca lutein cells?", "Can you see an area that appears to receive blood supply from branches of the ovarian artery?", "Is there a structure adjacent to developing follicles or the ovarian medulla?", "Does the image show evidence of a structure that develops from a ruptured ovarian follicle after ovulation?", "Can you identify a region that has undergone luteinization and vascularization following ovulation?", "Is there a structure located near the ovarian hilum but not directly associated with ducts or tubes?", "Does the image contain a feature found in the cortical region of the ovary within the female reproductive tract?", "Can you see a structure positioned close to the fallopian tube, which would receive an ovulated oocyte?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for producing hormones that regulate the menstrual cycle?", "Is there an object present that supports early pregnancy by secreting hormones?", "Can you identify a structure that secretes progesterone to maintain the endometrial lining?", "Does the image contain something that inhibits further ovulation through hormone secretion?", "Is there a feature that produces both progesterone and estrogen during the luteal phase?", "Can you see a structure that sustains the uterine lining for embryo implantation?", "Is there an object that promotes endometrial receptivity and inhibits uterine contractions?", "Does the image show a structure that increases progesterone levels, leading to secretory transformation of the endometrium?", "Can you identify an object that prepares the uterus for implantation by thickening and stabilizing the endometrial lining?", "Is there a structure that maintains pregnancy before placental development by preventing endometrial shedding?", "Does the image contain a feature whose formation and function are triggered by luteinizing hormone?", "Can you see evidence of luteolysis, such as the breakdown of luteal cells and a decline in hormone production leading to menstruation?"]}, "no_questions": {"contexual_properties": ["Do you see any changes in the texture of a horizontal crease on the ear lobe, such as roughness or irregularity, that might suggest scarring, fibrosis, or chronic skin disease?", "Are there multiple horizontal lines or additional creases on the ear lobe that might suggest repetitive mechanical stress or further aging?", "Is the horizontal crease on the ear lobe more noticeable in areas where the skin shows cumulative aging changes or loss of elasticity?"], "properties": ["Does the image show a feature on the ear lobe that is more commonly seen in adults over 50 years of age?", "Is there a horizontal crease present on both ear lobes rather than just one?", "Does the image show a linear, horizontal indentation on the anterior surface of the ear lobe, extending from the tragus toward the lower margin?"], "relational": ["Is there a visible crease in the lateral region of the head, specifically in the auricular area?", "Is there a surface feature found close to anatomical landmarks such as the tragus, antitragus, or lobule margin?", "Does the image display a marking that is part of the integumentary system and located on the external ear?"], "contexual_behavior": ["Is there a visible sign that could indicate impaired microcirculation due to reduced capillary blood flow in the tissue?", "Is there a visible sign that can indicate altered connective tissue function in the context of metabolic syndrome?", "Is there a visible sign that may deepen in response to chronic cardiovascular stress such as persistent hypertension?"], "functions": ["Can you identify a visible sign that may be used as a clinical marker for certain conditions?", "Does the image contain a physical sign that might be noted during a cardiovascular assessment?", "Can you see a feature that, while having no known physiological function, is sometimes evaluated in medical examinations?"]}}, "aorta": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the cardiovascular system?", "Can you identify a vessel that passes through both the thoracic and abdominal regions?", "Is there a large artery from which the coronary arteries, brachiocephalic trunk, left common carotid artery, or left subclavian artery branch off?", "Does the image display a vessel adjacent to the esophagus or vertebral column?", "Can you see a structure that is connected to the left ventricle of the heart?", "Is there evidence of a vessel with distinct sections such as an ascending portion, an arch, or a segment in the abdomen?", "Does the image include a vessel that supplies blood directly to organs like the brain, kidneys, or intestines?", "Can you identify two major parallel vessels responsible for arterial outflow and venous return?", "Is there a vessel surrounded by connective tissue, adipose tissue, or the pericardium near its origin?", "Does the image show a structure originating at the aortic root and receiving blood from the left ventricle via a valve?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for transporting oxygen-rich blood from the heart to the rest of the body?", "Can you identify a vessel that branches into major arteries supplying all regions of the body?", "Is there a structure with elastic walls that help maintain blood pressure during the cardiac cycle?", "Does the image contain a vessel that regulates blood flow to organs by distributing blood through branching arteries?", "Can you see a structure that receives blood during ventricular systole and releases it steadily during diastole?", "Is there a vessel that expands to accommodate increased blood volume and pressure during heightened cardiac output?", "Does the image show a structure that dampens the pulse pressure from the heart using elastic properties?", "Can you identify the main conduit for systemic circulation, delivering blood from the heart to all tissues except the lungs?", "Is there a vessel that supplies blood to the coronary arteries via openings just above a heart valve?", "Does the image contain a structure that facilitates nutrient and oxygen delivery to peripheral tissues through its arterial branches?"]}, "no_questions": {"contexual_properties": ["Is there visual evidence of cellular atypia in areas with abnormal glandular architecture, as seen in precancerous or malignant conditions?", "Does the image show tissue with features suggestive of epithelial hyperplasia or neoplastic transformation?", "Can you observe loss of normal gland spacing, as might occur in atypical hyperplasia or carcinoma?"], "properties": ["Is the distance between adjacent glands reduced, with minimal or no stroma separating them?", "Does the image show an area where glands are closely packed together with little intervening stroma?", "Can you identify a region where the number of glands per unit area appears significantly increased, possibly exceeding 10 per low-power field?"], "relational": ["Does the image show regions where glands are closely packed with little separation by stromal tissue?", "Does the image contain structures that could be classified as tubular, acinar, or endometrial glands?", "Is there evidence of altered glandular architecture, such as overlapping glandular profiles?"], "contexual_behavior": ["Is there evidence that dense cellular arrangements are hindering immune cell access or infiltration within glandular tissue?", "Can you identify a region where excessive cellular density appears to disrupt the normal architecture of acini or ducts, potentially impairing secretion?", "Is there a region where chronic overcrowding may have led to abnormal cell behavior or features suggestive of malignant transformation?"], "functions": ["Are there areas where glandular cells appear to be in closer proximity, possibly affecting cell-cell interactions or paracrine signaling?", "Is there visual evidence of abnormal glandular growth, such as clusters of proliferating cells or architectural distortion?", "Is there evidence that the local microenvironment around glands is altered, potentially affecting hormonal responses or receptor accessibility?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image contain an object that receives blood from the ovarian or uterine arteries?", "Does the image show a structure functionally or anatomically linked to the uterus through ovulation or ligamentous attachments?", "Can you identify structures such as ovarian follicles or corpus luteum?"], "contexual_behavior": [], "functions": ["Does the image show a region where progesterone is produced, particularly after ovulation?", "Can you identify a structure that plays a central role in female fertility by supporting oocyte maturation?", "Is there an object associated with the development of female reproductive tissues and secondary sexual characteristics?"]}}, "barium study": {"yes_questions": {"contexual_properties": ["Is there evidence of delayed passage of contrast material that might suggest a motility disorder or obstruction?", "Can you identify any narrowing of a hollow organ's lumen that could indicate a stricture, tumor, or inflammatory disease?", "Does the image show irregular patterns along the inner lining that might be seen in malignancy or inflammatory bowel disease?", "Are there any filling defects visible that could be caused by an intraluminal mass, polyp, or foreign body?", "Can you observe areas where contrast material is abnormally retained, possibly due to a diverticulum, ulcer, or delayed gastric emptying?", "Is there thickening of the folds that could be attributed to edema, inflammation, or an infiltrative process?", "Does the contrast material appear to move unusually quickly, suggesting a hypermotility disorder or a post-surgical state?", "Are there visible ulcerations that might indicate peptic ulcer disease, Crohn's disease, or malignancy?", "Can you see any outpouchings along the gastrointestinal tract, as might be present in diverticula or Meckel's diverticulum?", "Is there displacement of anatomical structures that could be due to a mass, hernia, or extrinsic compression?", "Are strictures apparent that might result from chronic inflammation, radiation injury, or a neoplastic process?", "Do you notice persistent filling defects or abnormal contours that could represent a mass or tumor?", "Is there evidence of mucosal edema, possibly related to acute inflammation, infection, or an allergic reaction?", "Are there abnormal contours of the organ that might be caused by a tumor, scarring, or a congenital anomaly?", "Can you identify any fistulous tracts that could be associated with Crohn's disease, diverticulitis, or post-surgical complications?", "Is there a loss of normal haustral markings, which could suggest chronic ulcerative colitis or toxic megacolon?", "Do you observe increased or decreased motility patterns that might indicate a functional bowel disorder or neuropathy?", "Is there abnormal coating of the contrast agent along the mucosa, possibly due to irregularity, inflammation, or neoplasia?", "Are there changes in the caliber of the bowel that could be explained by a stricture, tumor, or inflammatory process?", "Does the image show evidence of obstruction or blockage, such as might occur with a tumor, volvulus, or fecal impaction?"], "properties": ["Does the image show a procedure involving the administration of a white or off-white solution?", "Can you identify a process where a high-radiopacity medium is used to visualize the gastrointestinal tract on X-ray?", "Is there evidence of a suspension with a density between 1.2 and 1.5 grams per cubic centimeter being used?", "Does the image suggest the use of a contrast agent with a viscosity ranging from 30 to 1000 centipoise?", "Can you see signs of a preparation that is iso-osmotic or has an osmolality less than 300 mOsm/kg?", "Is there an indication of a solution with a pH between 5.0 and 8.0 being administered?", "Does the image imply the use of a suspension with barium sulfate particles smaller than 15 micrometers?", "Can you infer the presence of a contrast medium that is typically administered at room temperature, around 20 to 25 degrees Celsius?", "Is there a process depicted that would involve a chalky and bland-tasting solution?", "Does the image suggest the use of a preparation containing suspending agents, preservatives, or flavoring agents?", "Is there evidence that the contrast agent being used has a shelf life of 2 to 3 years when stored properly?", "Can you determine if the volume of contrast administered to an adult is between 150 and 250 milliliters?", "Does the image suggest a pediatric dosage of a suspension in the range of 2 to 4 milliliters per kilogram of body weight?", "Can you see any indication that the concentration of the contrast medium is between 40% and 100% weight/volume?"], "relational": ["Does the image show any part of the digestive system being examined using a contrast agent?", "Can you identify structures belonging to the gastrointestinal tract that are highlighted for assessment?", "Is there visualization of anatomical regions such as the esophagus, stomach, or intestines?", "Does the image display the mucosal lining or lumen of any gastrointestinal organ?", "Are there visible features of sphincters within the gastrointestinal tract?", "Can you see anatomical connections like the gastroesophageal junction or pyloric sphincter being evaluated?", "Is there evidence of contrast visualization used for structural assessment or motility evaluation of the gastrointestinal tract?", "Are tissues such as the mucosal epithelium or muscularis externa in contact with a radiopaque substance?", "Does the image appear to be part of a radiologic imaging or contrast radiography procedure?", "Can you identify any structural abnormalities such as strictures, ulcers, tumors, diverticula, polyps, fistulas, or hernias in the gastrointestinal tract?"], "contexual_behavior": ["Is there evidence in the image of poor visualization of the gastrointestinal tract that could be due to overlying gas or retained fecal material?", "Does the image suggest delayed or absent progression of contrast, which might indicate a bowel obstruction?", "Can you see signs of incomplete mucosal coating or limited imaging that could result from rapid intestinal transit?", "Is there impaired contrast coating or mucosal irregularity that might be explained by edema or ulceration from mucosal inflammation?", "Does the image show reduced sensitivity for detecting small lesions, possibly due to obscuration by active bleeding?", "Is there abnormal timing or distribution of contrast that could be related to altered gastric motility?", "Can you identify areas where retained fecal matter interferes with contrast flow or mucosal visualization, suggesting severe constipation?", "Are there artifacts or residual air present that might reduce the effectiveness of imaging following a recent endoscopic procedure?", "Does the image display enhanced mucosal coating and detailed visualization, possibly due to slow gastrointestinal transit?", "Is there evidence of abnormal contrast passage or extraluminal leakage that could indicate the presence of a fistula?", "Can you see signs of altered anatomy or surgical changes that might reduce the diagnostic value in a patient with prior gastrointestinal surgery?", "Are persistent narrowings or mucosal changes visible that could improve the detection of strictures in chronic inflammatory disease?", "Does the image suggest incomplete ingestion or possible airway entry of contrast, raising concerns about impaired swallowing or aspiration risk?", "Is there reduced peristalsis or altered visualization of the gastrointestinal lumen that could be attributed to the use of antispasmodic drugs?", "Can you observe abnormal movement or delayed transit of contrast that might be explained by a motility disorder?"], "functions": ["Does the image show a procedure used to visualize the structure and function of the gastrointestinal tract?", "Can you identify evidence of fluoroscopic imaging that tracks the movement of a contrast agent through the digestive tract?", "Is there a visible assessment of gastrointestinal motility, such as the progression of a radiopaque substance through the GI tract?", "Does the image reveal any structural abnormalities of the digestive tract, such as strictures, ulcers, or masses highlighted by a contrast agent?", "Can you see signs that suggest impaired swallowing, such as abnormal bolus transit or possible aspiration during the oropharyngeal phase?", "Is there visual information about the speed and coordination of a substance moving through the esophagus, indicating esophageal transit or peristalsis?", "Does the image allow evaluation of gastric emptying by showing the passage of a contrast agent from the stomach into the duodenum?", "Can you identify delayed or absent movement of a contrast agent at a specific site, suggesting intestinal obstruction or blockage?", "Is there evidence of the passage of a radiopaque substance through the small or large intestine, allowing assessment of transit and distribution?", "Does the image demonstrate retrograde flow of a contrast agent into the esophagus or airway, indicating reflux or aspiration?", "Can you compare transit times or motility patterns in the image to monitor the effectiveness of treatment for gastrointestinal motility disorders?"]}, "no_questions": {"contexual_properties": ["Is there loss of normal architecture that could be due to advanced neoplasia or severe inflammation?", "Can you identify polyps that could be consistent with adenomatous or juvenile polyps?", "Can you see submucosal hemorrhage that might be related to trauma or vasculitis?"], "properties": ["Is there evidence that the color balance setting is either auto white balance or manually adjusted?", "Can you assess whether the contrast ratio in the image is within the typical range of 300:1 to 1000:1?", "Can you determine if the image resolution falls within the range of VGA to Full HD?"], "relational": ["Are the boundaries of the visualized area defined by the mucosal surface, lumen boundary, or organ wall?", "Is there evidence that the image was captured from inside a region like the gastrointestinal, respiratory, or urinary tract?", "Can you see tissues such as epithelial, connective, or lymphoid tissue in the image?"], "contexual_behavior": [], "functions": ["Does the image appear to guide or facilitate minimally invasive procedures by showing precise navigation of instruments within the body?", "Can you identify any abnormalities such as lesions, tumors, or signs of inflammation in the internal tissues shown?", "Does the image facilitate identification of a bleeding source, such as active hemorrhage or vascular lesions within a lumen?"]}}, "stomach": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify an organ that is adjacent to the liver or pancreas?", "Is there a structure positioned near the spleen or transverse colon?", "Does the image display regions such as the cardia, fundus, body, antrum, or pylorus?", "Can you see evidence of blood supply from arteries like the left gastric or right gastric artery?", "Is there a structure that could be innervated by the vagus nerve or fibers from the celiac plexus?", "Does the image show a connection between the esophagus and another organ via a cardiac orifice?", "Can you identify a junction where the esophagus delivers ingested material to another structure?", "Is there a visible connection to the duodenum through a pyloric sphincter?", "Does the image reveal layers such as mucosa, submucosa, muscularis externa, or serosa in a wall of an organ?", "Can you see a lining that might contain parietal cells, chief cells, mucous cells, or enteroendocrine cells?", "Is there evidence of support or anchoring by the lesser omentum, greater omentum, or gastrosplenic ligament?", "Does the image show lymphatic structures such as gastric lymph nodes, gastroepiploic lymph nodes, or celiac lymph nodes near an organ?", "Can you identify an organ that interacts with both the esophagus and duodenum during digestion?", "Is there a structure in the image that could be involved in transferring contents from the esophagus to the small intestine?"], "contexual_behavior": [], "functions": ["Does the image show an organ responsible for storing ingested food before it enters the small intestine?", "Can you identify a structure that initiates the process of digestion?", "Is there an object that regulates the gradual passage of food into the small intestine?", "Does the image contain a structure that secretes gastric juices to aid in digestion?", "Can you see an organ that mechanically breaks down food through muscular contractions?", "Is there evidence of a structure that forms chyme by mixing food with digestive secretions?", "Does the image include a feature that controls the release of food via a sphincter at the junction with the small intestine?", "Can you identify a region where digestive enzymes like pepsinogen are secreted for protein breakdown?", "Is there a structure that produces hydrochloric acid to denature proteins and activate digestive enzymes?", "Does the image show an area where parietal cells might be present?", "Can you see a structure that creates an acidic environment to destroy ingested pathogens?", "Is there evidence of coordinated muscular contractions that mix and churn food with secretions?", "Does the image contain a region where substances such as alcohol or medications could be absorbed directly into the bloodstream?", "Can you identify an organ that releases hormones like ghrelin to regulate appetite?", "Is there a structure involved in the production of gastrin for hormonal regulation of digestion?", "Does the image show a region where pepsin is activated to hydrolyze proteins?", "Can you see an area that provides antimicrobial defense through high gastric acidity?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": [], "contexual_behavior": [], "functions": ["Can you see a part that alters its opening size to adapt to different light intensities, likely involving the iris?", "Can you see a pathway or connection that might transmit visual signals to the brain, such as an optic nerve?", "Does the image suggest a role in regulating circadian rhythms by transmitting light information to the brain?"]}}, "gastrointestinal system": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any organs that are part of the digestive tract, such as the esophagus or intestines?", "Can you identify structures located within the abdominal or pelvic cavities that are part of a continuous canal?", "Is there evidence of tissue layers like mucosa or muscularis externa in any visible organ?", "Does the image include organs or tissues that interact closely with the circulatory or nervous systems?", "Can you see blood vessels such as the celiac artery or portal vein supplying any of the depicted organs?", "Is there a visible structure that could be innervated by the vagus nerve or enteric nervous system?", "Does the image show ducts, such as the bile duct or pancreatic duct, associated with digestive organs?", "Can you identify any glands, such as gastric or intestinal glands, within the depicted tissues?", "Is there anatomical support, like the mesentery or omentum, visible in relation to the digestive organs?", "Does the image include features of the alimentary canal extending from the thoracic to the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a system responsible for both digestion and absorption of nutrients?", "Can you identify structures involved in the mechanical or chemical breakdown of food, such as those facilitating enzyme activity?", "Is there evidence of nutrient uptake occurring primarily in a region associated with absorptive cells?", "Does the image display anatomical features where mastication or gastric acid secretion might take place?", "Can you see a region specialized for water absorption that contributes to fluid homeostasis?", "Is there a structure involved in the formation of feces or the process of defecation?", "Does the image include tissues or regions associated with gut-associated lymphoid tissue or mucosal immune defense?", "Can you identify areas where hormones like gastrin, secretin, or cholecystokinin might be produced to regulate digestive processes?", "Is there visual evidence of an environment supporting commensal bacteria or maintaining microbiota balance?", "Can you see features that provide protection against pathogens, such as mucus layers or sites of immune surveillance?", "Does the image show regions where motility or peristalsis is regulated by smooth muscle or neural signaling?", "Is there an area where electrolyte absorption or ion transport might occur to maintain homeostasis?", "Can you identify structures participating in detoxification, possibly in coordination with the liver?", "Is there evidence of bacterial vitamin synthesis, such as regions supporting the production of vitamin K?", "Does the image suggest coordination with other organ systems, such as nervous or endocrine, to optimize digestion or nutrient assimilation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show other lesions near the abnormality, such as metastatic nodules or benign pulmonary masses?", "Is there an abnormality contained within the right lung, specifically in the B5 bronchopulmonary segment?", "Does the image show a lesion located within the respiratory system, specifically in the lungs?"], "contexual_behavior": [], "functions": ["Is there evidence of abnormal structures that could indicate uncontrolled cell proliferation?", "Does the image contain a lesion that could be associated with abnormal metabolic activity or resistance to therapy?", "Does the image display features suggestive of new blood vessel formation or altered vasculature?"]}}, "appendix": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a narrow, blind-ended tubular structure visible in the image?", "Can you identify an object that measures between 6 and 10 centimeters in length?", "Does the image show a structure with a diameter of about 6 millimeters?", "Is there a soft, pliable structure present among the tissues?", "Can you see something with a pinkish-gray color similar to other intestinal tissues?", "Is there a feature whose wall thickness appears to be around 2 to 3 millimeters?", "Does the image include a structure that could weigh between 7 and 10 grams?", "Can you identify a region that contains abundant lymphoid tissue, especially in the submucosa?", "Is there a tubular structure that receives blood supply from a branch of the ileocolic artery?", "Can you see a tissue with a water content estimated at 70 to 80 percent by weight?", "Is there a structure lined by simple columnar epithelium with goblet cells?", "Does the image show a region with moderate mucin content produced by goblet cells?", "Can you identify an object with a volume of about 1 to 2 milliliters?", "Is there a tissue whose density is close to 1.05 grams per cubic centimeter?", "Can you see a structure whose temperature would match core body temperature, around 37 degrees Celsius?", "Is there a feature with a lumen pH estimated to be neutral to slightly alkaline, around 7.0 to 8.0?", "Does the image include a structure composed of mucosal epithelial cells, lymphocytes, goblet cells, and enteroendocrine cells?"], "relational": ["Does the image show a structure that is part of the digestive system and located in the right lower quadrant of the abdomen?", "Can you identify a blind-ended tube extending from the cecum?", "Is there a structure attached to the posteromedial wall of the cecum?", "Does the image contain an object adjacent to the ileum or parietal peritoneum?", "Can you see a structure that might be supplied by a branch of the ileocolic artery?", "Is there evidence of a wall composed of mucosa, submucosa, muscularis propria, and serosa layers?", "Does the image show prominent lymphoid follicles within submucosal tissue?", "Can you identify a structure that receives innervation from the superior mesenteric plexus or the vagus nerve?", "Is there a tube-like structure surrounded by peritoneal and connective tissue in the image?"], "contexual_behavior": ["Is there a structure in the image that shows increased lymphoid activity in response to gastrointestinal infection?", "Can you identify an object whose immune function might be reduced following antibiotic use due to disrupted gut microbiota?", "Does the image show a structure that could fail to contribute to mucosal immunity in the presence of inflammation and obstruction?", "Is there evidence of tissue remodeling or depletion in lymphoid tissue that could result from chronic inflammation?", "Can you see a structure that might display decreased immune factor secretion in elderly individuals due to atrophy?", "Is there an absence of a structure that would impair the recolonization of beneficial gut bacteria after surgical removal?", "Does the image contain a structure that would be expected to have enhanced defense against pathogens during early childhood?", "Can you identify an object whose immune surveillance might be reduced in an immunocompromised state due to lymphocyte suppression?", "Is there a structure that could increase its activity in response to changes in gut microbial populations?", "Does the image show a structure that might fail to support gut immunity during severe infection due to tissue damage or overwhelming inflammation?"], "functions": ["Does the image show a structure that could serve as a reservoir for lymphoid tissue?", "Is there an object present that might contribute to immune surveillance within the gastrointestinal tract?", "Can you identify a feature that could act as a safe haven for beneficial gut bacteria?", "Does the image contain a component of gut-associated lymphoid tissue, such as one housing lymphocytes or follicles?", "Is there a structure that may facilitate the maturation of B cells or support immune education?", "Can you see an anatomical feature that might participate in the regulation of intestinal bacteria through biofilm formation?", "Is there an object that could be involved in antibody production or immune cell activation?", "Does the image include a structure that may support the proliferation of lymphocytes or the formation of germinal centers?", "Can you identify a region that might help protect against gastrointestinal infections by promoting beneficial microbiota?", "Is there a visible feature that could function as a microbial niche or reservoir for maintaining gut flora?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show something with a width in the range of 1 to 3 centimeters?", "Can you identify a structure that might have a density between 1.03 and 1.06 grams per cubic centimeter, consistent with biological tissue?", "Is there an area displaying a color that ranges from pale pink to reddish-brown?"], "relational": ["Can you see connective tissues like loose connective tissue, dense connective tissue, adipose tissue, or cartilage within the section?", "Can you identify neighboring organs, surrounding tissues, blood vessels, or fascia adjacent to the main structure in the image?", "Does the image show regions from the head, thorax, abdomen, or limbs in a sectional representation?"], "contexual_behavior": ["Is there a visible area where clot formation appears delayed, possibly indicating a bleeding disorder?", "Is there an area where tissue regeneration appears to have failed, as seen in chronic wounds?", "Does the image display signs of excessive inflammation that might be associated with autoimmune disease?"], "functions": ["Can you identify blood vessels or vascular patterns that highlight areas of perfusion or ischemia?", "Does the image provide a way to assess morphological changes that could indicate disease progression?", "Can you observe details that would allow analysis of cellular composition or tissue integrity?"]}}, "x-ray": {"yes_questions": {"contexual_properties": ["Does the image display increased opacity that could indicate accumulation of fluid, infection, or a mass in a particular area?", "Is there evidence of decreased density that might suggest loss of normal tissue mass, as seen in conditions like emphysema or osteoporosis?", "Can you identify abnormal shadows that could be due to tumors, infiltrates, or the presence of a foreign body?", "Does the image reveal any enlarged organs, such as an increased heart or liver size, which might indicate organomegaly?", "Is there visible thinning of bone structures that could be consistent with decreased bone mineral content?", "Can you see signs of fluid accumulation in spaces like the pleura or abdomen?", "Does the image show any areas of calcification that might result from chronic inflammation or metabolic disorders?", "Is there evidence of tissue swelling, such as increased soft tissue volume from inflammation, trauma, or infection?", "Can you detect loss of normal anatomical structure that could be due to destruction or distortion from trauma, infection, or malignancy?", "Does the image reveal any disruptions in bone continuity that might indicate a fracture?", "Are there abnormal air patterns present, such as air outside normal anatomical locations?", "Can you observe changes in lung volume, such as hyperinflation or collapse, that might be related to diseases like COPD or atelectasis?", "Is there narrowing of joint spaces that could suggest degenerative or inflammatory joint disease?", "Does the image show any abnormal soft tissue or bone growths that might represent a mass or tumor?", "Can you identify areas of bone overgrowth, such as excessive bone formation or osteophytes?", "Is there abnormal alignment of bones or joints, such as displacement or angulation, visible in the image?", "Does the image display changes in bone density that could be associated with metabolic or neoplastic bone diseases?", "Is there evidence of soft tissue thickening that might result from inflammation, infection, or neoplastic infiltration?", "Can you see an abnormal heart size that could indicate cardiac enlargement?", "Does the image reveal loss of bone structure that could be due to infection, malignancy, or severe trauma?"], "properties": ["Does the image display features that could be produced by electromagnetic radiation with a wavelength between 0.01 and 10 nanometers?", "Is there evidence of imaging that relies on photon energies in the range of 1 to 150 kiloelectronvolts?", "Can you identify visual characteristics that suggest the use of electromagnetic waves with frequencies between 3 \u00d7 10^16 and 3 \u00d7 10^19 hertz?", "Does the image show structures that would require penetration depths of 1 to 10 centimeters in soft tissue?", "Are there visual differences that could be explained by an attenuation coefficient of 0.2 to 0.5 per centimeter in bone?", "Is the image quality consistent with an intensity of 10^4 to 10^6 photons per square millimeter per second?", "Does the visual appearance suggest a radiation dose in the range of 0.01 to 0.1 millisieverts?", "Can you infer that the exposure duration for this image was between 1 and 500 milliseconds?", "Is the spatial resolution of the image within the range of 0.1 to 0.5 millimeters?", "Does the image exhibit contrast levels that could result from a 1% to 5% difference in tissue density?", "Is the grayscale range of the image consistent with 8 to 16 bits per pixel?", "Can you deduce that the photon flux used to create this image was between 10^12 and 10^15 photons per second?", "Does the image field appear to have a width between 0.5 and 2 millimeters for the beam used?", "Is the field size of the image within the range of 18 \u00d7 24 centimeters to 35 \u00d7 43 centimeters?", "Does the image suggest that the energy spectrum of the beam was continuous from 20 to 150 kiloelectronvolts?", "Can you infer that the voltage used to generate the image was between 40 and 150 kilovolts peak?", "Is there evidence that the current used in the imaging process was between 1 and 500 milliamperes?", "Does the image display a noise level that could be between 1% and 10% of the signal?", "Is the film sensitivity implied by the image quality within the 100 to 400 speed index range?"], "relational": ["Does the image allow visualization of structures such as bones or joints?", "Can you identify regions like the chest, abdomen, or limbs being examined?", "Is there evidence of tissues with varying densities, such as bone, air-filled spaces, or soft tissue?", "Does the image provide information about the skeletal, respiratory, or cardiovascular systems?", "Can you assess bone alignment or joint spaces in the image?", "Is there a visible structure that could be the femur, tibia, or spine?", "Can you see organs such as the lungs or heart in the image?", "Is the position of the trachea or diaphragm discernible?", "Does the image reveal any signs of fractures, dislocations, or calcifications?", "Can you identify anatomical planes such as lateral or anteroposterior views?", "Is there a body part, such as the hand, foot, or pelvis, positioned specifically for examination?", "Can you detect any abnormalities like tumors or infections in the visible structures?", "Does the image show the relationship between bones and surrounding soft tissues?", "Is it possible to evaluate organ position within the thoracic or abdominal cavity?", "Can you distinguish fat from other soft tissues in the image?"], "contexual_behavior": ["Does the image suggest reduced diagnostic effectiveness in the presence of increased tissue thickness, such as in obese individuals?", "Can you determine if the image provides primarily structural rather than functional information, especially in the context of acute inflammation?", "Is there evidence that the detection of bone fractures in the image would not be improved by the use of a contrast agent?", "Does the image appear to have difficulty revealing soft tissue abnormalities that might be present in early stages of disease?", "Can you identify pulmonary changes, such as consolidation or infiltrates, that would become more apparent in the setting of pneumonia?", "Is there a reduction in the ability to detect tumors when dense tissue or overlapping structures are present in the image?", "Does the image suggest potential impairment of cellular function in radiosensitive tissues if the radiation dose is high?", "Can you observe any artifacts or obscured anatomical details that might be caused by the presence of metallic implants?", "Is there altered visualization of organs that could be related to physiological changes during pregnancy or efforts to minimize fetal radiation exposure?", "Does the image show signs that could result from repeated exposure, such as increased DNA damage or impaired DNA repair mechanisms?", "Is there enhanced detection of radiopaque calcifications that might be associated with chronic kidney disease?", "Does the image make it difficult to distinguish between acute and chronic bone infections due to similar radiographic features?", "Is the reliability of the image reduced by increased soft tissue density, as might occur in severe edema?", "Can you see improved visualization of lung fields that could result from deep inspiration and increased air volume?", "Does the image have limited diagnostic value for detecting early-stage osteoarthritis due to the invisibility of initial cartilage loss?"], "functions": ["Does the image provide visual information that could assist in diagnosing internal body structures?", "Can you identify any discontinuities or abnormal alignments in bones that might indicate a fracture?", "Is there evidence of abnormalities in the lungs, such as infiltrates, masses, or fluid accumulation?", "Does the image allow for comparison with previous images to monitor changes in anatomical structures over time?", "Can you see features that would help guide a medical procedure, such as the placement of a catheter or orthopedic hardware?", "Are there visible signs of dental issues, such as cavities, tooth decay, or bone loss in the jaw or teeth?", "Is there an abnormal mass, lesion, or calcification present that could suggest malignancy?", "Can you assess the alignment of bones, joint spaces, or signs of degeneration in joints or the spine?", "Are there any indications of chest abnormalities, such as pneumonia, pleural effusion, or enlargement of the heart?", "Is there a radiopaque object visible that could represent a foreign body within tissues or organs?"]}, "no_questions": {"contexual_properties": ["Can you identify areas where cellular proliferation appears reduced, as might be seen in late pregnancy or placental insufficiency?", "Are there visible structural changes consistent with pathological remodeling, such as those found in trophoblastic tumors?", "Do you see an increased number of mitotic figures within rapidly expanding lesions of trophoblastic origin?"], "properties": ["Does the image show evidence of increased cell numbers in the outermost fetal membrane?", "Can you identify regions where the surface layer of the chorion appears thicker than usual?", "Is there a visible indication of active cell division in the epithelial covering of the chorion?"], "relational": ["Can you identify a region contributing to the structure of the placenta?", "Is there a structure that is separated from the amniotic membrane by the extraembryonic mesoderm?", "Does the image contain layers such as cytotrophoblast and syncytiotrophoblast?"], "contexual_behavior": ["Does the image show evidence of increased cellular activity in the outermost fetal membrane?", "Is there a visible indication of abnormal growth or expansion in the tissue covering the fetal side of the placenta?", "Does the image contain areas suggestive of enhanced cell division within the chorionic surface?"], "functions": ["Does the image show evidence of increased surface area in a structure that supports fetal-maternal interactions?", "Can you identify features consistent with the formation or branching of villi within the placenta?", "Is there a continuous epithelial layer visible that could serve as a selective barrier regulating molecular passage between maternal and fetal tissues?"]}}}
[ { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "no", "extracted_concepts": [], "question": "is natural color present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bilateral cleft palate" ], "question": "is bilateral cleft palate present?" }, { "answer": "no", "extracted_concepts": [ "metastatic carcinoma breast", "breast" ], "question": "is metastatic carcinoma breast present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" } ]	["bilateral cleft palate", "breast", "metastatic carcinoma breast", "face"]	{"bilateral cleft palate": {"yes_questions": {"contexual_properties": ["Does the image show a palatal gap that appears wider than usual, possibly indicating a pre-surgical or growing state?", "Can you observe a deepened separation in the palate that might result from vertical growth of the maxilla during childhood?", "Is there evidence of significant tissue deficiency in the palatal region, suggesting a preoperative or delayed repair condition?", "Do you see abnormal tissue characteristics, such as irregular surfaces, that could be associated with chronic inflammation or infection?", "Is there a palatal defect that appears more pronounced, possibly reflecting a period of rapid craniofacial growth without surgical intervention?", "Can you identify areas of redness or purplish discoloration in the palate, which may indicate infection or inflammation?", "Is there visible scar tissue in the palatal region, suggesting previous surgical repair?", "Do you notice swelling in the palate that could be due to recent surgery or acute infection?", "Is the palatal gap visibly reduced, possibly indicating a successful surgical intervention?", "Can you detect the presence of fluid or exudate in the palatal area, which might be due to infection, inflammation, or fistula formation?", "Are there any ulcerations or open sores in the palate that could result from trauma, infection, or poor oral hygiene?", "Do you see abnormal mucosal texture, such as roughness or irregularity, possibly due to repeated infections, scarring, or failed repairs?", "Is the palatal separation less apparent, potentially reflecting tissue remodeling after surgical repair and aging?", "Can you observe signs of bleeding in the palatal region, which may occur during surgery, trauma, or acute infection?", "Is there a visible fistula or abnormal opening in the palate, possibly indicating a postoperative complication or incomplete healing?"], "properties": ["Is there a structure in the image that shows a gap measuring between 5 and 20 millimeters in width?", "Can you identify a separation extending from the incisive foramen to the uvula, with a length of approximately 20 to 40 millimeters?", "Does the image display a shallow to moderate depression, with a depth between 2 and 8 millimeters, in the palatal region?", "Is there a visible V-shaped or U-shaped gap along the midline of the palate?", "Can you see a midline defect affecting both the hard and soft palate symmetrically?", "Does the image show a structure with a frequency of occurrence in live births between 0.02 and 0.05 percent?", "Is there tissue present that appears pink to reddish, possibly with areas of erythema, in the palatal region?", "Can you identify disrupted mucosa, connective tissue, or exposed bone or cartilage within a palatal gap?", "Does the image reveal a complete separation between the palatal shelves, with no fusion at the midline?", "Is there an area where the palatal tissue thickness is reduced to less than 2 millimeters?", "Can you observe an irregular or uneven surface texture, possibly with ulcerations or granulation tissue, in the palate?", "Is there evidence of bony defects in the palatal region, given that such defects are present in more than 90 percent of similar cases?", "Does the image show involvement of both the hard and soft palate, with the hard palate nearly always affected and the soft palate in most cases?", "Can you see discontinuity or compromised integrity of the mucosa, with exposure of underlying structures in the palate?", "Is the distance between two cleft margins in the palatal region within the range of 5 to 20 millimeters?"], "relational": ["Does the image show a disruption involving both the hard and soft regions forming the roof of the oral cavity?", "Can you identify a gap or separation affecting the midline and lateral aspects of the palatal shelves?", "Is there evidence of interrupted continuity in the maxilla or palatine bones within the oral cavity?", "Does the image reveal separation of the mucosal, muscular, and bony layers of the palate?", "Can you observe a defect indicating failure of fusion between the palatal processes of the maxilla?", "Is there a visible abnormality that could impact muscles such as the levator veli palatini or tensor veli palatini?", "Does the image show a structure adjacent to the nasal septum, upper lip, or lateral nasal wall that appears disrupted?", "Are the anatomical boundaries from the alveolar ridge to the uvula and lateral palatal shelves visibly altered?", "Can you detect additional anomalies such as a cleft in the upper lip, irregular dental development, or nasal deformities?", "Is there an abnormal opening between the oral and nasal cavities that could affect speech or feeding?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structural defect that could allow food or liquids to pass from the mouth into the nasal cavity, potentially leading to nasal regurgitation?", "Is there a visible abnormal communication between the oral and nasal spaces that might disrupt normal swallowing or oropharyngeal coordination?", "Can you identify a feature that could prevent proper closure of the velopharyngeal port, possibly resulting in hypernasal speech or articulation difficulties?", "Does the image suggest a condition that would make it difficult for an infant to create suction during feeding, potentially leading to poor intake or prolonged feeding times?", "Is there a structural abnormality that could compromise airway protection during eating or drinking, increasing the risk of aspiration or choking?", "Can you see an oronasal fistula or palatal defect that disrupts the normal separation between the oral and nasal cavities?", "Does the image show a feature that might alter nasal airflow or increase the likelihood of airway obstruction, possibly causing breathing difficulties?", "Is there evidence of a defect that could reduce the ability to generate intraoral pressure, affecting effective sucking, swallowing, or speech sound production?", "Can you identify a structural issue that might impair Eustachian tube function, increasing the risk of recurrent ear infections or middle ear effusion?", "Does the image suggest disturbances in facial growth or dental alignment, such as maxillary deficiency or malocclusion?", "Is there any indication that the individual may have developed compensatory mechanisms, such as atypical speech articulation or altered swallowing patterns, to adapt to a structural defect in the palate?"]}, "no_questions": {"contexual_properties": ["Can you see a distended tube near the ovary, which might indicate hydrosalpinx or tubal obstruction?", "Can you observe cystic changes in a tube adherent to the ovary, as seen in hydrosalpinx or chronic salpingitis?", "Does the image show signs of inflammation in a tube adjacent to the ovary, as might occur during pelvic inflammatory disease or infection?"], "properties": ["Can you identify a structure that would contain ciliated epithelial cells, secretory cells, smooth muscle cells, and stromal cells?", "Is there a structure where fibrosis appears minimal under normal conditions?", "Does the image show a structure with considerable elasticity, allowing for distension and contraction?"], "relational": ["Does the image show a structure that is part of the female reproductive system and appears physically attached to an adjacent ovary?", "Can you identify a tube-like structure in the pelvic region that is in direct contact with an ovary on the opposite side?", "Does the image show a structure located near the ovary, uterus, urinary bladder, or rectum within the pelvic region?"], "contexual_behavior": ["Is there evidence of a tube-like structure with narrowed or blocked lumen, suggesting possible impairment of fertilization due to inflammation or fibrosis?", "Is there visual evidence of anatomical distortion or fibrosis in a tube-like structure, suggesting dysfunction possibly related to endometriosis?", "Can you identify a structure where ciliary movement might be altered, possibly as a result of pelvic inflammatory disease affecting the ciliated epithelium?"], "functions": ["Can you see any indication of mechanical obstruction or altered function in a tube that could lead to infertility?", "Is there a structure visible that appears to be attached to an adjacent ovary, potentially affecting the capture and transport of an egg toward the uterus?", "Is there a structure whose adherence to the ovary could hinder the passage of an embryo toward the uterus, suggesting a risk of tubal obstruction?"]}}, "breast": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears enlarged, which could be associated with physiological states like puberty, pregnancy, or lactation, or with pathological conditions such as tumors or hormonal imbalance?", "Can you identify any swelling that might be due to inflammation, infection, trauma, allergic reaction, or premenstrual changes?", "Does the image show any area with altered coloration, such as bruising or redness, that could indicate inflammation, infection, or malignancy?", "Is there a visible lump or mass that could correspond to benign conditions like fibroadenoma or cysts, or to malignant processes?", "Can you observe increased tissue density that might be related to hormonal changes, pregnancy, lactation, fibrocystic changes, or aging?", "Is there evidence of tenderness, such as protective posture or localized swelling, that could be explained by premenstrual syndrome, pregnancy, lactation, infection, or trauma?", "Does the structure display increased vascularity, which might be seen during pregnancy, lactation, inflammation, or in the presence of a tumor?", "Is there any thickening of the skin that could be due to chronic inflammation, lymphedema, infection, or malignancy?", "Can you see dimpling or puckering of the skin, which may suggest underlying malignancy or fibrosis?", "Is there asymmetry between paired structures that could result from developmental variation, trauma, surgery, tumor, or localized swelling?", "Does the image suggest loss of volume, possibly due to menopause, significant weight loss, aging, or surgical intervention?", "Is there any evidence of abnormal discharge that could indicate infection, duct ectasia, intraductal papilloma, or malignancy?", "Can you observe areas of increased firmness, which might be caused by fibrosis, scarring, tumors, or chronic inflammation?", "Are there visible calcifications that could be associated with aging, benign fibrocystic changes, or ductal carcinoma in situ?", "Does the texture of the tissue appear altered, such as with edema, inflammation, fibrosis, or skin involvement by malignancy?", "Is there redness or signs of inflammation that could be due to infection, mastitis, inflammatory malignancy, or allergy?", "Can you identify edema, possibly resulting from lymphatic obstruction, inflammation, infection, or malignancy?", "Is there increased nodularity that might be explained by fibrocystic changes, hormonal fluctuations, or benign proliferative disorders?", "Does the tissue show signs of fatty replacement, which could occur with aging, after menopause, or following significant weight loss?", "Are there areas of skin ulceration that may be due to advanced malignancy, chronic infection, or trauma?"], "properties": ["Is there a structure in the image that typically measures between 10 and 12 centimeters in diameter?", "Can you identify an object whose average weight might be between 200 and 400 grams?", "Does the image show a structure with a hemispherical or conical shape?", "Is there an area with skin color ranging from light to medium brown, depending on individual pigmentation?", "Can you see a region where tissue density could be estimated between 0.9 and 1.1 grams per cubic centimeter?", "Is there a structure likely composed of epithelial cells, myoepithelial cells, adipocytes, fibroblasts, and immune cells?", "Does the image show a region where fat could make up 50% to 70% of the tissue?", "Is there an object where glandular tissue might constitute 15% to 30% of its total volume?", "Can you identify a structure whose volume could be estimated between 200 and 500 milliliters?", "Is there a region where water content might account for 30% to 40% of the tissue by weight?", "Does the image show a structure with a soft and pliable texture, possibly with some firmness?", "Is there an area where the tissue pH could be slightly acidic, around 7.0 to 7.4?", "Can you see a structure that might contain 15 to 20 lobules?", "Is there an object with approximately 15 to 20 ducts, corresponding to the number of lobules?", "Does the image show a region where collagen content could be about 1% to 2% of the tissue by weight?", "Is there a structure where elastin content might be approximately 0.1% to 0.2% by weight?", "Can you identify an area with a temperature close to core body temperature, about 36.5 to 37\u00b0C?", "Is there a region where the pigmentation of a circular area ranges from pink to dark brown?", "Does the image show a protruding structure with a diameter of about 1 to 1.5 centimeters?", "Is there an area where the skin thickness could be approximately 1.5 to 2 millimeters?"], "relational": ["Does the image show a structure that is part of both the integumentary and reproductive systems?", "Can you identify a region that is adjacent to the chest wall, axilla, or clavicle?", "Is there an area composed of glandular, adipose, and connective tissues?", "Does the image contain glands specialized for milk production?", "Can you see a region that receives blood supply from the internal thoracic artery or lateral thoracic artery?", "Is there a structure connected to axillary or parasternal lymph nodes?", "Can you identify an area innervated by intercostal or supraclavicular nerves?", "Does the image show ducts that could transport secretions to the surface?", "Is there a structure located superficial to the chest wall and separated by a distinct space?", "Can you see anatomical support provided by ligaments or fascia in the region?", "Is there evidence of connections to supraclavicular lymph nodes?", "Does the image show features consistent with the presence of lactiferous ducts?", "Can you identify supporting structures such as Cooper\u2019s ligaments or pectoral fascia?"], "contexual_behavior": ["Does the image show a structure that could increase milk production in response to infant suckling?", "Is there evidence of a tissue that might reduce its secretory activity after weaning or hormonal decline?", "Can you identify a structure that may fail to respond to hormonal stimulation in cases of endocrine dysfunction?", "Does the image contain a tissue that could secrete immunoglobulins and antimicrobial factors during lactation?", "Is there a structure that might show impaired milk ejection if oxytocin release is insufficient?", "Can you see evidence of glandular growth or differentiation that might occur during pregnancy due to hormonal changes?", "Is there a tissue that could undergo involution or regression after lactational hormones subside?", "Does the image show a structure with increased blood flow that might support rapid tissue growth during puberty?", "Can you identify a tissue that may reduce its secretory function due to decreased estrogen and progesterone, as seen in menopause?", "Is there evidence of impaired tissue repair that could result from poor vascularization or chronic inflammation?", "Does the image contain a structure that could provide passive immunity to an infant by transferring antibodies?", "Is there a tissue that might decrease its response to prolactin with aging or hormonal imbalance?", "Can you see signs of increased inflammatory response and reduced secretion that might occur during mastitis?", "Is there evidence of insufficient milk production or ductal obstruction that could affect infant nutrition?", "Does the image show a tissue that could increase lipid synthesis to enrich milk with essential fatty acids?", "Is there a structure that might have reduced antimicrobial activity in disease states such as mastitis?", "Can you identify a tissue whose function could be altered by endocrine disorders like hypothyroidism or diabetes?", "Does the image show a structure with increased metabolic demand that might be required for sustained milk synthesis during breastfeeding?", "Is there evidence of compromised epithelial integrity that could reduce protective barrier function?", "Can you see signs of impaired ductal transport or blockage that might affect milk flow?"], "functions": ["Does the image show a structure involved in providing nourishment to infants?", "Can you identify an area responsible for milk production and secretion?", "Is there evidence of a system that includes alveoli and ducts for transporting milk?", "Does the image depict a region that could participate in the suckling reflex?", "Can you see a structure that supports infant growth by supplying essential nutrients?", "Is there an object whose function is regulated by hormones such as prolactin or oxytocin?", "Does the image contain a region that undergoes changes in response to reproductive hormones?", "Can you identify tissue that might proliferate or enlarge during pregnancy or breastfeeding?", "Is there a structure that could transfer immunoglobulins or antimicrobial proteins to an infant?", "Does the image show an area that acts as an endocrine organ during lactation?", "Can you see evidence of a system that supports passive immunity in infants?", "Is there a structure that might be involved in the transfer of secretory IgA to support immune development?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify any narrowing or abnormalities in arteries such as the left anterior descending, right coronary, or left circumflex artery?", "Does the image show evidence of early pathological changes in the vessels supplying blood to the heart muscle?", "Is there a visible indication of accelerated atherosclerosis in the coronary circulation?"], "contexual_behavior": [], "functions": ["Can you identify features that might explain exercise intolerance, such as reduced endurance capacity or exertional angina?", "Can you observe structural or functional changes in the heart muscle that might indicate contractile dysfunction or systolic impairment?", "Is there any indication of decreased oxygen delivery to cardiac tissue, such as areas of hypoperfusion or hypoxia?"]}}, "metastatic carcinoma breast": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any abnormality affecting the mammary gland or its surrounding tissues?", "Is there evidence of involvement of the lymphatic or circulatory systems in the image?", "Can you identify changes in the breast parenchyma, connective tissue, or lymphatic tissue?", "Does the image reveal lesions or abnormalities in regions such as bone, lung, liver, or brain that could indicate secondary involvement?", "Are there visible alterations in axillary, supraclavicular, or internal mammary lymph nodes?", "Can you see any structures that suggest spread through lymphatic vessels or blood vessels?", "Is there any indication of pathology originating from ductal or lobular epithelium?", "Does the image show abnormalities near the axillary vein, internal mammary vein, or thoracoacromial artery?", "Are there signs of disease affecting the skeletal, respiratory, hepatic, or nervous systems?", "Can you identify any anatomical pathways, such as lymphatic or blood vessels, that appear to facilitate the spread of disease?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure that could have a phosphorus concentration of about 17 to 18 percent by weight?", "Is there a dome-shaped, convex structure visible in the image?", "Does the image display a bone region whose hardness might be around 3 to 4 on the Mohs scale?"], "relational": ["Can you see a region that overlies the meninges and the cerebral cortex?", "Can you identify an area formed by the parietal bones and the upper portion of the frontal bone?", "Does the image show anatomical landmarks like the bregma, sagittal suture, or coronal suture?"], "contexual_behavior": [], "functions": ["Can you identify a region that provides support for the scalp and overlying soft tissues?", "Is there a region that contains spongy bone with spaces housing bone marrow involved in blood cell production?", "Does the image show a structure that acts as a rigid barrier protecting the upper part of the brain from external injury?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify an abnormality involving the pulmonary parenchyma or bronchial epithelium?", "Is there an abnormality contained within the right lung, specifically in the B5 bronchopulmonary segment?", "Can you see evidence of malignant epithelial cells or infiltrating inflammatory cells within a lesion?"], "contexual_behavior": [], "functions": ["Can you identify a region where the normal tissue architecture is distorted or disrupted?", "Does the image display features suggestive of new blood vessel formation or altered vasculature?", "Does the image suggest the presence of a mass with the potential for metastasis, such as evidence of cell motility or entry into blood vessels?"]}}}
[ { "answer": "lateral view close-up typical", "extracted_concepts": [], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "close-up", "lateral view" ], "question": "does this image show lateral view close-up typical?" }, { "answer": "no", "extracted_concepts": [ "lateral view" ], "question": "does there show lateral view close-up typical?" }, { "answer": "anencephaly", "extracted_concepts": [ "anencephaly" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "anencephaly" ], "question": "is anencephaly present?" }, { "answer": "no", "extracted_concepts": [ "uterus", "peritoneal carcinomatosis", "ovaries", "implants", "serosal surfaces" ], "question": "is excellent example of peritoneal carcinomatosis with implants on serosal surfaces of uterus and ovaries present?" }, { "answer": "anencephaly", "extracted_concepts": [ "anencephaly" ], "question": "what is present?" } ]	["uterus", "close-up", "peritoneal carcinomatosis", "ovaries", "implants", "lateral view", "serosal surfaces", "anencephaly"]	{"uterus": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify a region that could correspond to the fundus, body, isthmus, or cervix?", "Is there an organ located adjacent to the bladder or rectum?", "Does the image contain a structure positioned near the ovaries?", "Can you see blood vessels that might be the primary supply to a reproductive organ, such as the uterine artery or vein?", "Is there evidence of supporting ligaments like the broad ligament, round ligament, or uterosacral ligament?", "Does the image show a connection between the ovaries and another structure via tubular pathways?", "Can you identify features related to the menstrual or reproductive cycles?", "Is there a visible anatomical connection between a structure and the vagina?", "Can you see tissue layers that could correspond to the endometrium, myometrium, or perimetrium?", "Does the image show tubular structures connecting to a larger organ at the uterine cornua?", "Is there an organ located within the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a structure that supports embryo implantation or fetal development?", "Is there an organ present that undergoes cyclical changes in its lining in response to hormones?", "Can you identify a tissue that sheds periodically as part of menstruation?", "Does the image contain a structure that provides a protective environment for fetal growth?", "Is there evidence of an organ that expands during pregnancy to accommodate a growing fetus?", "Can you see a structure that supports placental attachment and maternal-fetal exchange?", "Is there an object that generates coordinated muscular contractions to facilitate childbirth?", "Does the image show a tissue that responds to hormones such as estrogen or progesterone?", "Is there a structure that produces secretory factors to facilitate embryo implantation?", "Can you identify an organ that forms a physical barrier and provides immunological protection for a developing fetus?", "Does the image contain a structure responsible for expelling menstrual blood and tissue?", "Is there evidence of rhythmic contractions under the influence of oxytocin to aid in delivery?", "Can you see a tissue that supplies nutrients and removes waste for fetal development?", "Is there an organ whose structural and functional changes are regulated by reproductive hormones?", "Does the image show a structure essential for fertility, pregnancy support, or menstrual health?"]}, "no_questions": {"contexual_properties": ["Is there an opening in the skull that appears to have an irregular or asymmetric shape, possibly due to congenital malformation or bone remodeling?", "Does the image reveal compression of a cranial aperture caused by excessive bone formation, tumor presence, or herniation of nearby tissues?", "Can you identify irregular bone growth at the base of the skull that could indicate disorders such as osteopetrosis or Paget\u2019s disease?"], "properties": ["Is there a region at the base of the skull where the opening appears narrowed by approximately 30% to 60% compared to typical anatomy?", "Does the image show a structure at the cranial base that appears oval or irregular instead of round?", "Does the image suggest a reduction in the volume of a cranial opening by approximately 30% to 50%?"], "relational": ["Is there any indication of altered passage where the spinal cord connects to the brainstem?", "Can you observe displacement or crowding of cranial structures such as the cerebellar tonsils or clivus near the skull base?", "Does the image show any abnormal narrowing at the craniovertebral junction or skull base?"], "contexual_behavior": [], "functions": ["Does the image show evidence of compression affecting neural or vascular structures at the base of the skull?", "Can you identify features suggesting compression of the lower brainstem or upper cervical spinal cord?", "Can you see any abnormality that might impinge on the medulla oblongata or upper cervical spinal cord?"]}}, "close-up": {"yes_questions": {"contexual_properties": ["Is there a region where the surface texture appears rough, smooth, or irregular compared to surrounding tissue?", "Can you identify any areas with visible color changes, such as discoloration from bruising or inflammation?", "Does the image show localized swelling or signs of fluid accumulation in any tissue?", "Are there any masses, nodules, or irregular tissue formations visible that might indicate abnormal growths or lesions?", "Can you see regions with increased redness or pallor, suggesting changes in blood flow or oxygenation?", "Is there evidence of unusual moisture or dryness on the tissue surface compared to what is typically expected?", "Do you observe any scaling or flaking, indicating shedding or accumulation of keratinized cells?", "Are there visible changes in the vascular pattern, such as prominent or dilated blood vessels?", "Can you identify any open sores or areas where the tissue surface appears eroded or ulcerated?", "Is there variation in pigmentation, such as areas of hyperpigmentation, hypopigmentation, or mottling?", "Do you see regions where the tissue appears abnormally thickened or thinned?", "Are there any signs of abnormal secretions, such as exudate or pus, present on the tissue surface?", "Can you spot any purple, red, or brown spots that might indicate bruising or petechiae?", "Is there a noticeable difference in how transparent or opaque certain tissue areas appear?", "Do you observe any disruptions in tissue integrity, such as fissures, cracks, or breakdown of the surface?"], "properties": [], "relational": ["Does the image contain a magnified view of a specific anatomical structure?", "Can you identify a region that is a detailed portion of a larger anatomical area?", "Is there a view that allows you to see tissue types such as epithelial, connective, or muscle tissue in greater detail?", "Does the image show cellular components like epithelial cells, fibroblasts, or endothelial cells at high magnification?", "Is there a magnified area that is part of a body system such as the musculoskeletal, integumentary, or digestive system?", "Can you see anatomical landmarks such as fissures, sulci, glands, or blood vessels in a detailed view?", "Does the image display layers like the epidermis, dermis, subcutaneous tissue, or mucosa in a focused region?", "Is there a region in the image where adjacent tissues or neighboring anatomical features are visible next to a magnified structure?", "Can you observe the spatial relationship, such as proximity or orientation, between a detailed area and its surrounding anatomy?"], "contexual_behavior": ["Does the image provide enhanced visualization of tissue abnormalities, such as detailed mucosal patterns or subtle lesions?", "Is it possible to identify early-stage lesions due to high-resolution visualization of epithelial surfaces?", "Does the view in the image make it difficult to assess overall organ function because of a limited field of view?", "Is the ability to evaluate global motility or broader anatomical context impaired by the perspective shown?", "Can you observe fine vascular patterns or microvascular changes that might indicate pathological conditions due to increased magnification?", "Does the image allow for improved identification of minor textural or color alterations in mucosal surfaces, which could suggest inflammation?", "Is the detection rate of small tumors potentially increased in this image because of enhanced contrast and magnification?", "Does the image hinder the assessment of functional movement or joint interactions due to a limited focus on a small area?", "Is the evaluation of dynamic physiological processes or temporal changes limited by the spatial context provided in the image?", "Does the image facilitate detailed monitoring of wound healing, such as visualization of granulation tissue and epithelialization, especially in diabetic patients?", "Is the effectiveness of surgical navigation or spatial orientation reduced because anatomical landmarks are obscured by the perspective shown?"], "functions": []}, "no_questions": {"contexual_properties": ["Do any regions appear fibrotic or scarred, suggesting chronic healing or scarring processes?", "Is there evidence of abnormal tissue composition, such as the presence of atypical cells or changes in the extracellular matrix?", "Do any areas show increased swelling or edema, possibly resulting from acute inflammation or vascular leakage?"], "properties": ["Does the image contain a region with indistinct, irregular, or poorly demarcated borders?", "Is there a region that seems to contain a mixture of necrotic tissue, inflammatory cells, and viable tissue?", "Does the image show an area with coloration that appears red, purple, or pale?"], "relational": ["Does the abnormal region appear to span compartments such as intracavitary spaces or visceral cavities?", "Can you identify an area that might affect the nervous or digestive systems?", "Is there a region that could impact the integumentary or musculoskeletal systems?"], "contexual_behavior": [], "functions": ["Can you identify regions where organ performance might be reduced due to structural or functional compromise?", "Is there evidence of nerve injury or sensory loss, such as damaged neural pathways or blocked signal transmission?", "Are there features suggesting increased susceptibility to infection, possibly due to compromised tissue barriers or impaired immune surveillance?"]}}, "peritoneal carcinomatosis": {"yes_questions": {"contexual_properties": ["Is there evidence of thickening or rigidity in the lining that covers the abdominal organs?", "Can you observe any abnormal accumulation of fluid within the abdominal cavity?", "Are there visible nodules or irregular deposits on the surfaces lining the abdominal cavity?", "Does the serosal lining appear less smooth or more irregular than expected?", "Is there any indication of fibrous tissue formation or areas of fibrosis within the peritoneal surfaces?", "Do you notice any discoloration, hemorrhage, or necrotic areas affecting the lining of the abdominal cavity?", "Can you see granular or roughened areas on the serosal surfaces, possibly due to small tumor implants?", "Are there signs of calcification within nodular deposits on the peritoneal surfaces?", "Does the peritoneal lining appear more opaque or thickened than usual, obscuring its normal translucency?", "Is there visual evidence suggesting increased vascular permeability or lymphatic obstruction, such as excessive fluid accumulation?", "Can you identify any changes in the appearance of ascitic fluid that might suggest the presence of malignant cells or altered composition?", "Are there features indicating chronic inflammation or tumor invasion, such as persistent fibrous tissue or irregularity?", "Does the image show any loss of the normal smoothness of the peritoneal cavity due to nodules, fibrosis, or inflammation?"], "properties": ["Does the image show multiple nodules ranging from a few millimeters to several centimeters in size?", "Can you identify numerous lesions distributed diffusely across peritoneal surfaces such as the omentum or mesentery?", "Is there evidence of tumor deposits with an average thickness between 1 and 10 millimeters?", "Do you observe nodules that appear white, gray, or tan in color?", "Are there structures that seem to have a firm or hard consistency?", "Can you see lesions that might be composed of malignant epithelial cells and stromal cells?", "Is there visual evidence suggesting a high degree of cellular proliferation, such as densely packed tumor cells?", "Do the lesions appear to be of moderate to high grade, suggesting poor differentiation?", "Are there areas that could indicate elevated mucin content, especially in the context of mucinous tumors?", "Can you identify regions with increased vascular density, possibly due to angiogenesis?", "Is there any indication of protein markers such as cytokeratins, CEA, or CA125 within the lesions?", "Do the tumor cells show features consistent with abnormal chromosomal content, such as aneuploidy?", "Is there evidence of a high Ki-67 proliferation index, potentially exceeding 20%?", "Are there lesions that demonstrate increased metabolic activity, such as high FDG uptake on PET imaging?"], "relational": ["Does the image show abnormal findings in the abdominal or pelvic cavity?", "Can you identify any involvement of the omentum or omental fat?", "Is there evidence of disease affecting organs such as the ovaries, stomach, colon, liver, or small intestine?", "Does the image reveal changes associated with the parietal or visceral peritoneum?", "Can you see signs of malignant infiltration of the peritoneal lining or subserosal tissue?", "Is there any indication of spread within the peritoneal or pelvic cavity?", "Are mesenteric, para-aortic, or pelvic lymph nodes visibly affected?", "Does the image suggest impact on the digestive, reproductive, or lymphatic systems?", "Are there abnormalities near anatomical barriers like the omental bursa, mesenteric reflections, or ligaments of the liver?", "Can you observe features that might indicate dissemination via peritoneal fluid, the omentum, or the mesentery?"], "contexual_behavior": ["Is there evidence of abnormal fluid accumulation in the abdominal cavity that could suggest impaired absorption or lymphatic obstruction?", "Can you identify signs of local inflammation in the peritoneal lining, such as thickening or increased vascularity, that might indicate a tumor-induced inflammatory response?", "Does the image show features consistent with mechanical obstruction or compression of the bowel or mesentery that could disrupt intestinal motility?", "Are there indications of altered immune activity in the peritoneal region, such as immune cell infiltration or changes in tissue appearance, that might reflect tumor-immune interactions?", "Can you observe any signs of ascites formation, such as free fluid in the abdomen, that could result from increased vascular permeability or impaired lymphatic drainage?", "Is there visual evidence of compromised nutrient absorption, such as changes in the intestinal surface or bowel wall, that might suggest malabsorption or nutritional deficit?", "Does the image reveal disruption of the mesothelial layer or increased permeability in the peritoneum, suggesting barrier breakdown due to malignant infiltration?", "Are there visible masses or nodules encasing or compressing segments of the intestine that could increase the risk of bowel obstruction?", "Can you detect any features that might indicate delayed healing or surgical complications in the peritoneum, such as persistent defects or abnormal tissue regeneration?", "Is there evidence of increased susceptibility to infection in the peritoneal cavity, such as signs of infection spread or compromised barriers?", "Does the image suggest impaired peritoneal membrane function, such as thickening or irregularity, that could decrease the effectiveness of peritoneal dialysis?", "Are there signs of new blood vessel formation in the peritoneal cavity, such as increased vascularity, that might indicate angiogenesis driven by tumor activity?", "Can you observe features that suggest toxin accumulation or impaired clearance in the peritoneal space, possibly due to lymphatic blockage?", "Is there evidence of protein-rich fluid or increased protein leakage in the peritoneal cavity, which could result from increased permeability and inflammatory damage?", "Do you see signs of lymphatic vessel obstruction or edema in the abdomen that might indicate impaired lymphatic drainage?", "Are there visual cues suggesting changes in the cytokine environment, such as altered cellular composition or tissue appearance in the peritoneum?", "Does the image show abnormal tissue remodeling, fibrosis, or extracellular matrix changes in the peritoneum that could result from tumor invasion?", "Is there evidence of weakened physical or immune barriers in the peritoneum, such as areas of barrier compromise or infection spread?", "Can you detect alterations in the composition of peritoneal fluid, such as changes in protein content or cellularity, that might reflect tumor activity?", "Are there signs of direct invasion, compression, or obstruction of abdominal organs that could interfere with their normal function?"], "functions": ["Does the image show evidence of widespread tumor implantation on peritoneal surfaces?", "Can you identify signs of inflammation or organ dysfunction within the abdominal cavity?", "Is there visible accumulation of fluid in the abdomen that could indicate ascites?", "Does the image suggest increased vascular permeability or impaired fluid resorption in the peritoneal cavity?", "Are there indications of mechanical compression or obstruction affecting abdominal organs?", "Can you see features consistent with exfoliation and implantation of malignant cells within the abdomen?", "Is there evidence of bowel obstruction, mucosal infiltration, or malabsorption that could impact nutrient absorption?", "Does the image reveal signs of chronic inflammation or immune cell recruitment in the peritoneal cavity?", "Are there visual cues suggesting capillary leakage or lymphatic obstruction contributing to fluid accumulation?", "Can you identify areas of tumor infiltration or increased permeability of the peritoneal membrane?", "Is there evidence of local inflammatory processes, such as cytokine production or recruitment of inflammatory cells?", "Does the image show features like bowel wall infiltration, adhesions, or mechanical obstruction that could interfere with gastrointestinal motility?"]}, "no_questions": {"contexual_properties": ["Is the horizontal crease on the ear lobe more noticeable in areas where the skin shows cumulative aging changes or loss of elasticity?", "Does the horizontal crease on the ear lobe coincide with changes in ear lobe size, such as atrophy or hypertrophy of the tissue?", "Is there a reduction in the visibility of a horizontal ear lobe crease in areas where the skin appears tighter or after cosmetic intervention?"], "properties": ["Does the image show a feature on the ear lobe that is more commonly seen in adults over 50 years of age?", "Can you identify a shallow crease, less than 1 millimeter deep, on the ear lobe?", "Is there a visible indentation on the ear lobe that is more likely to be found bilaterally than unilaterally?"], "relational": ["Is there a visible crease in the lateral region of the head, specifically in the auricular area?", "Does the image display a marking that is part of the integumentary system and located on the external ear?", "Can you observe a crease associated with the skin and underlying connective tissue of the ear lobe?"], "contexual_behavior": ["Does the image contain a marker that may reflect altered collagen metabolism in someone with diabetes mellitus?", "Is there a visible sign that may deepen in response to chronic cardiovascular stress such as persistent hypertension?", "Is there a visible sign that could indicate impaired microcirculation due to reduced capillary blood flow in the tissue?"], "functions": ["Does the image contain a physical sign that might be noted during a cardiovascular assessment?", "Can you identify a visible sign that may be used as a clinical marker for certain conditions?", "Is there a crease present that could be associated with increased cardiovascular risk?"]}}, "ovaries": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of both the female reproductive and endocrine systems?", "Can you identify an object located within the pelvic cavity or lower abdomen?", "Is there a structure adjacent to the uterus or fallopian tubes?", "Does the image contain an object that receives blood from the ovarian or uterine arteries?", "Can you see a structure supported by ligaments such as the suspensory, ovarian, or broad ligament?", "Is there an anatomical connection between the fallopian tubes and another structure via fimbriae?", "Does the image show tissues like germinal epithelium, cortex, medulla, or stromal tissue?", "Can you identify structures such as ovarian follicles or corpus luteum?", "Is there a visible object that contains blood vessels and connective tissue within it?", "Does the image show a structure functionally or anatomically linked to the uterus through ovulation or ligamentous attachments?", "Can you see evidence of innervation by the ovarian plexus or superior hypogastric plexus?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for producing and releasing eggs?", "Can you identify an organ involved in hormone secretion that regulates the menstrual cycle?", "Is there a structure present that participates in follicle development and ovulation?", "Does the image contain an organ that synthesizes hormones such as estrogen and progesterone?", "Can you see a structure that cyclically releases hormones to control endometrial changes?", "Is there an object associated with the development of female reproductive tissues and secondary sexual characteristics?", "Does the image show a region where progesterone is produced, particularly after ovulation?", "Can you identify a structure that plays a central role in female fertility by supporting oocyte maturation?", "Is there an organ that provides the microenvironment necessary for folliculogenesis?", "Does the image include a structure that responds to luteinizing hormone surges to initiate ovulation?", "Can you see an organ whose hormone production influences traits like breast development and fat distribution?", "Is there a structure involved in reproductive aging, such as the reduction of follicle numbers leading to menopause?", "Does the image show an organ that interacts with the hypothalamic-pituitary axis through feedback regulation?", "Can you identify a structure that helps maintain bone health by secreting hormones that regulate bone remodeling?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show a structure that might contain moderate amounts of type I and III collagen fibers?", "Can you see a region that might contain mesothelial cells or fibroblasts?", "Can you see a structure that might allow the passage of small molecules and fluids?"], "relational": ["Does the image contain a membrane similar in appearance to the pericardium or pleura?", "Can you identify a structure that forms the outermost layer of the stomach, small intestine, large intestine, or uterus?", "Can you see a membrane that is continuous with the peritoneum?"], "contexual_behavior": ["Can you identify increased cytokine production or inflammatory response following trauma in the depicted tissues?", "Does the image show a structure whose protective barrier function might be reduced during inflammation or infection?", "Is there a surface that could display heightened immune activity during peritonitis, such as immune cell recruitment or inflammation?"], "functions": ["Is there a structure present that could help contain infections by limiting the spread of pathogens within a body cavity?", "Is there a thin membrane visible that provides a protective covering for internal organs?", "Does the image include a membrane that might support tissue repair by providing a scaffold for cell migration?"]}}, "implants": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show an object present within the musculoskeletal, cardiovascular, nervous, or reproductive systems?", "Is there a structure attached to bones, soft tissue, or cartilage?", "Can you identify an object interacting with connective, muscle, or epithelial tissue?", "Is there a foreign object located in the chest, abdomen, limbs, or oral cavity?", "Does the image show something associated with bones such as the femur, tibia, humerus, or spine?", "Is there an object placed within or adjacent to organs like the heart, brain, eye, or cochlea?", "Can you see a structure separated from surrounding tissue by a fibrous capsule, periosteum, or mucosal membrane?", "Is there an object positioned near arteries, veins, or capillaries?", "Does the image show something in proximity to peripheral, spinal, or cranial nerves?", "Can you identify an object located in anatomical spaces such as the subcutaneous space, intramedullary canal, or intraperitoneal cavity?"], "contexual_behavior": [], "functions": ["Does the image show an object that appears to replace or enhance a biological structure?", "Can you identify something that supports or restores the function of damaged tissues or organs?", "Is there a device present that provides mechanical strength or acts as a scaffold for tissue support?", "Does the image contain an object that reinforces or stabilizes bones, joints, or soft tissues?", "Can you see a structure that might serve as a reservoir or controlled-release system for therapeutic agents?", "Is there evidence of a device that could restore mobility or joint function by replacing joint surfaces?", "Does the image include an object that might deliver electrical impulses to nerves or muscles?", "Is there a structure that could act as a scaffold or fixation device to promote bone healing or regeneration?", "Can you identify something that provides mechanical, electrical, or chemical support to an organ?", "Is there a device present that might replace or assist heart valves, blood vessels, or cardiac rhythm?", "Does the image show an object that could substitute or enhance sensory input, such as for hearing or vision?", "Is there evidence of a structure designed for long-term or sustained drug release?", "Can you see an object that appears to integrate with biological tissue or form a mechanical or biochemical interface?", "Is there a device that seems to reshape, support, or reconstruct an anatomically deformed body part?", "Does the image contain a structure that could replace missing teeth or support dental prosthetics?"]}, "no_questions": {"contexual_properties": ["Can you identify a region that decreases in volume over time, possibly reflecting blood resorption and tissue contraction in the chronic phase?", "Does the image show signs of iron deposition, such as areas of low signal intensity, consistent with hemosiderin accumulation in the chronic phase?", "Is there an area with increased mass effect, such as compression of adjacent structures, due to edema or hematoma expansion in the acute to subacute phase?"], "properties": ["Is there a structure whose estimated volume appears to be a few milliliters to several tens of milliliters?", "Is there a region with heterogeneous signal and areas of hypointensity on T2-weighted MRI, consistent with blood products?", "Is there a lesion measuring between 1 and 5 centimeters in diameter visible in the image?"], "relational": ["Is there a focus containing necrotic cells, red blood cells, or inflammatory cells?", "Does the image reveal evidence of vessel occlusion, hemorrhage, or ischemia in a localized area?", "Does the lesion have boundaries defined by vascular territories, tissue planes, or infarct margins?"], "contexual_behavior": ["Can you identify a well-demarcated zone where tissue appears infarcted and contains blood extravasation?", "Does the image display a region with evidence of localized tissue damage accompanied by bleeding?", "Does the image show a focal lesion characterized by both necrosis and hemorrhagic features?"], "functions": ["Does the image show a region where tissue appears damaged due to both lack of blood flow and bleeding?", "Is there a region that suggests breakdown of the blood-brain barrier, possibly indicated by increased permeability or endothelial injury?", "Can you see evidence of impaired tissue repair, such as extensive cell loss or disruption of the extracellular matrix in a focal area?"]}}, "lateral view": {"yes_questions": {"contexual_properties": ["Does the image reveal any evidence of increased organ size suggestive of pathological enlargement?", "Can you identify areas of abnormal tissue density that might indicate consolidation, fibrosis, or infiltrative disease?", "Is there any visible structural deformity that could be due to congenital anomaly, trauma, or degeneration?", "Does the image show displacement of anatomical structures that might suggest the presence of a mass, effusion, or herniation?", "Can you observe any signs of swelling or edema, such as soft tissue expansion or increased radiolucency?", "Is there evidence of bone thickening that could be consistent with osteopetrosis, chronic osteomyelitis, or Paget\u2019s disease?", "Does the image display loss of normal anatomical contours that might result from collapse, erosion, or mass effect?", "Can you see any abnormal calcification patterns that could indicate dystrophic, metastatic, or tumoral calcification?", "Are there changes in tissue opacity that suggest the presence of fluid, fat, or air in abnormal locations?", "Does the image reveal any mass lesions, such as abnormal soft tissue densities or opacities?", "Is there a reduction in joint space that could be associated with degenerative joint disease, arthritis, or cartilage loss?", "Can you identify abnormal air or fluid levels that might indicate pneumothorax, pleural effusion, or abscess formation?", "Does the image demonstrate changes in alignment that could be due to fracture, dislocation, or subluxation?", "Is there evidence of soft tissue enlargement that might be related to tumor, infection, or inflammation?", "Can you observe abnormal curvature or angulation that could be consistent with scoliosis, kyphosis, or post-traumatic deformity?"], "properties": ["Does the image display the side profile of anatomical structures such as the skull, ribs, or spine?", "Can you identify whether the orientation of the image is from the left or right side of the body?", "Is the field of view in the image encompassing the entire region of interest from side-to-side, such as the thorax or a limb?", "Does the image use a grayscale color representation, or do you observe color as might be seen in advanced imaging techniques?", "Is the contrast in the image sufficient to distinguish between bone, soft tissue, and air spaces?", "Can you estimate if the scale or magnification appears true-to-size, as is standard for certain imaging modalities?", "Does the resolution of the image appear consistent with what is expected for X-ray, CT, or MRI (for example, fine enough to resolve features at the level of 100 to 300 microns)?", "Is the image likely acquired using X-ray radiography, or does it resemble images produced by CT, MRI, or ultrasound?", "Do the dimensions of the image suggest a standard size, such as 14 x 17 inches for X-ray or 512 x 512 pixels for digital images?", "Based on the visual appearance, can you infer if the exposure time was brief, as is typical for acquiring images of this type (for example, between 0.01 and 0.1 seconds)?"], "relational": ["Does the image display anatomical structures such as the skull, spine, ribs, or limbs from a side perspective?", "Can you identify regions like the head, thorax, abdomen, or limbs as seen from a lateral orientation?", "Is the orientation of the image perpendicular to the sagittal plane and parallel to the coronal plane?", "Are bones such as the femur, humerus, vertebrae, or pelvis visible from a side view?", "Does the image allow observation of organs like the lungs, heart, liver, or kidneys from a lateral aspect?", "Can you distinguish tissues such as muscle, bone, subcutaneous fat, or skin in the current view?", "Is the skeletal, respiratory, or muscular system best visualized in this image?", "Are anatomical landmarks such as the acromion, greater trochanter, or lateral malleolus identifiable from this perspective?", "Does the image provide information about the depth relationships or overlapping of anatomical structures?", "Are structures adjacent to the ones in view, such as medial structures, contralateral organs, or deep tissues, partially visible or implied in the image?"], "contexual_behavior": ["Does the image provide a profile perspective that could reveal anatomical changes associated with advanced disease stages, such as pneumonia or tumor growth?", "Can you identify a view that enhances detection of vertebral or posterior rib fractures, especially in the context of trauma?", "Is there a perspective in the image that would make lateral displacement or collapse of organs, as seen in atelectasis or diaphragmatic hernia, more apparent?", "Does the image allow for better visualization of joint instability or subluxation in the sagittal plane, such as in knee or cervical spine injuries?", "Can you see a view that would make anterior-posterior airway narrowing or epiglottic swelling, as seen in croup or epiglottitis, more evident during respiratory distress?", "Is there a perspective that improves detection of bone displacement or angulation after acute injury, such as in distal radius or spinal fractures?", "Does the image make it difficult to distinguish diffuse or anterior/posterior soft tissue swelling from normal structures, potentially limiting assessment of infection?", "Can you identify a view that enhances visualization of posterior pleural effusions or interlobar fluid accumulation, as might occur in heart failure?", "Is there a perspective that highlights abnormal motion or joint space narrowing in the sagittal plane, aiding in the assessment of musculoskeletal disorders like spondylolisthesis or osteoarthritis?", "Does the image provide a profile that would make shifts in organ position, such as diaphragmatic excursion or changes in the cardiac silhouette during deep inspiration, more pronounced?"], "functions": ["Does the image present a perspective that enhances visualization of anatomical relationships from the side?", "Can you identify alignment or displacement of musculoskeletal structures that might not be visible from a frontal view?", "Is there evidence of structural abnormalities, such as fractures or masses, that are more apparent from a side perspective?", "Does the image allow assessment of spatial relationships and positioning of organs relative to each other?", "Can you observe joint spaces and alignment in a way that demonstrates range of motion from a lateral angle?", "Is the anteroposterior dimension of the airway visible, allowing evaluation for possible narrowing or obstruction?", "Does the image reveal hidden fractures or soft tissue injuries that may not be detected in other projections?", "Can you use this view to monitor anatomical changes over time for disease progression by comparing serial images?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of involvement of meningeal layers such as the dura mater or arachnoid mater?", "Can you identify a mass effect on brainstem structures like the pons or medulla oblongata?", "Does the image show a mass located within the infratentorial region of the brain?"], "contexual_behavior": [], "functions": ["Is there evidence of vestibulocochlear nerve compression, such as findings that could be associated with hearing loss, tinnitus, or vertigo?", "Can you see any abnormalities that might explain balance disturbance or gait ataxia due to involvement of cerebellar or vestibular pathways?", "Can you identify features that suggest dysfunction of cranial nerves IX, X, or XII, potentially affecting swallowing or speech?"]}}, "serosal surfaces": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure in the image that appears pale, glistening, and translucent?", "Can you identify a surface that looks smooth and slippery?", "Does the image show a semi-transparent layer through which underlying structures are faintly visible?", "Is there a region that could be composed of a thin layer, approximately 20 to 40 micrometers thick?", "Can you see a structure that might be supported by connective tissue containing collagen and elastin fibers?", "Is there an area that could be lined by a single layer of mesothelial cells?", "Does the image show a surface that might have high water content, making up about 70\u201380% of its mass?", "Can you identify a region that could cover a large surface area, such as up to 1\u20132 square meters in the peritoneal cavity?", "Is there a surface that appears moderately elastic, possibly due to the presence of elastin fibers?", "Can you see a layer that is likely to have a neutral pH, around 7.0 to 7.4?", "Is there a structure that might contain proteins at concentrations similar to plasma ultrafiltrate, about 1\u20133 g/dL?", "Does the image show a surface that likely has low lipid content, primarily composed of membrane phospholipids?", "Can you identify a region that could be at core body temperature, approximately 36.5\u201337.5\u00b0C?", "Is there a surface whose density appears similar to that of soft tissue, around 1.05 g/cm\u00b3?", "Does the image show a layer that might be rich in glycoproteins, such as mucins secreted by specialized cells?"], "relational": ["Does the image show a membrane lining organs of the digestive, respiratory, or cardiovascular systems?", "Can you identify a surface that covers the stomach, intestines, lungs, or heart?", "Is there a structure adjacent to a body cavity or connective tissue?", "Does the image contain a membrane such as the peritoneum, pleura, or pericardium?", "Can you see a cavity that could be the peritoneal, pleural, or pericardial cavity?", "Is there a visible layer formed by mesothelium or connective tissue?", "Does the image show a lining that covers abdominal organs or the abdominal cavity?", "Can you identify a membrane enveloping the lungs or lining the thoracic cavity?", "Is there a structure surrounding the heart that could be a serosal membrane?", "Does the image reveal layers such as a mesothelial layer or submesothelial connective tissue?"], "contexual_behavior": ["Does the image show evidence of reduced lubrication between organs, such as might occur during dehydration or low blood volume?", "Is there any indication of inflammation that could impair organ movement, as seen in conditions like peritonitis or pleuritis?", "Can you identify signs of increased fluid secretion or exudate formation that might suggest infection or acute inflammation?", "Is there visual evidence of barrier dysfunction, such as loss of separation between tissues, possibly due to severe inflammation or injury?", "Does the image reveal adhesions that could restrict organ mobility, potentially resulting from previous surgery, infection, or chronic inflammation?", "Are there signs of increased friction or surface damage between organs, which might result from diminished lubricating fluid?", "Can you observe features suggesting increased permeability of a mesothelial layer, possibly due to cytokine activity during inflammation?", "Is there any indication of reduced anti-inflammatory function, such as persistent irritation or chronic disease affecting tissue appearance?", "Does the image suggest altered fluid absorption, as might be seen in disease states like cirrhosis or heart failure?", "Are there signs that infection control is impaired, such as evidence of infection spread in the context of immunosuppression or extensive tissue damage?", "Can you detect impaired healing after injury, possibly associated with diabetes, malnutrition, or ongoing inflammation?", "Is there visible fibrin deposition, which could indicate an inflammatory response such as peritonitis?", "Does the image show signs of fluid accumulation that might result from hypoalbuminemia or congestive heart failure?", "Are there features suggesting increased permeability and possible tumor dissemination, as might occur in malignancy?", "Is there evidence of disrupted tissue separation following trauma, possibly due to mesothelial layer disruption?"], "functions": ["Is there a structure in the image that forms a protective lining around internal organs within a body cavity?", "Can you identify a surface that appears to provide a lubricated interface enabling smooth movement of organs?", "Does the image show a boundary that could reduce friction between adjacent organs, possibly through the presence of serous fluid?", "Is there evidence of a structure involved in fluid secretion or absorption within the body cavity?", "Can you see a surface that might shield internal organs from mechanical injury or infection?", "Does the image contain a region that could house immune cells or participate in inflammatory responses?", "Is there a visible boundary that compartmentalizes or separates organs within the cavity?", "Can you identify an area that might respond to injury or inflammation by producing exudates?", "Is there a structure that appears to regulate fluid balance or maintain homeostasis within the cavity?", "Does the image show a barrier that could help prevent the spread of infection or support immune surveillance?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a gene that spans approximately 84,188 base pairs?", "Can you identify a protein that contains domains such as BRC repeats, a DNA-binding domain, or OB-folds?", "Is there evidence of a nucleotide sequence matching the reference sequence GenBank: NM_000059?"], "relational": ["Can you identify tissues from the reproductive system, such as ovarian, testicular, or breast tissue?", "Is there evidence of replication foci or nuclear foci within any cells present in the image?", "Are there cells present that could be epithelial cells, germ cells, or lymphocytes?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a process that facilitates DNA repair through homologous recombination?", "Is there evidence of cell cycle checkpoints being activated in response to DNA damage?", "Can you identify a structure or event where RAD51 is being recruited to sites of double-strand DNA breaks?"]}}, "anencephaly": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show an individual with a markedly reduced cranial size compared to normal?", "Is there evidence of microcephaly or a head circumference far below the expected range for gestational age?", "Can you identify a case where the cranial vault appears absent or severely underdeveloped, potentially exposing underlying tissue?", "Is there visible neural tissue that appears dark red to purple and has a friable, gelatinous texture?", "Does the image reveal disorganized or incomplete remnants of forebrain and midbrain structures?", "Can you see exposed neural tissue with a disorganized appearance and absence of the cerebrum?", "Is there a near-complete absence of skull bones in the cranial region?", "Does the brain tissue volume appear severely diminished, possibly limited to rudimentary brainstem structures?", "Is there evidence of malformed brainstem or primitive neural elements with no visible cerebral hemispheres?", "Can you infer from the image that the brain weight would likely be significantly below normal, possibly less than 100 grams?"], "relational": ["Does the image show absence or severe malformation of major structures such as the cerebral hemispheres or cranial vault?", "Is there a region of the head where the scalp appears missing or abnormal?", "Can you identify abnormalities affecting the forebrain or midbrain regions?", "Does the image reveal missing parts of the brain such as the cerebral cortex or cerebrum?", "Is there evidence of absent or malformed diencephalon in the cranial area?", "Are the bones of the skull or meninges visibly absent or disrupted?", "Can you see areas where neural tissue is exposed or not covered by cranial bone or skin?", "Is there a failure of cranial bone or overlying ectoderm development visible in the image?", "Does the image suggest a disruption in neural tube closure, particularly at the anterior end?", "Are there visible abnormalities in both the nervous and integumentary systems of the head?", "Can you identify regions where embryological structures such as the neural plate or neural folds may have failed to develop properly?", "Is the interface between the brain and skull altered, with evidence of exposed neural tissue?", "Does the upper facial region or calvaria appear structurally abnormal or incomplete?", "Is there a lack of normal scalp covering the cranial region?", "Are the skull bones missing or severely underdeveloped in the cranial area?"], "contexual_behavior": ["Does the image show evidence of a neural tube defect affecting the development of brain structures during early embryogenesis?", "Can you identify a fetus with malformation or absence of major brain regions that would disrupt central autonomic control?", "Is there a visible absence or severe underdevelopment of the forebrain and cerebrum, suggesting reduced neural control of vital physiological processes?", "Does the image indicate impaired coordination of fetal movement due to missing or underdeveloped motor cortex and neural circuits?", "Can you observe signs of failed sensory processing in the fetus, possibly due to missing sensory relay centers in the brain?", "Is there evidence of disrupted signaling between the brain and other organs, as might occur if neural pathways for inter-organ communication are absent?", "Does the image suggest abnormal regulation of heart rate or respiration that could result from a malformed or absent brainstem?", "Can you see indications that hypothalamic or pituitary structures have failed to develop, potentially affecting neurohormone production?", "Is there a decreased capacity for reflex responses in the fetus, possibly due to incomplete or absent neural circuits in the brain?", "Does the image show a lack of integration of neural pathways necessary for survival after birth, as would be expected if critical brain regions are missing?"], "functions": ["Does the image show an individual with severe malformation of the brain, particularly lacking the cerebral hemispheres and forebrain?", "Can you identify a case where neural regulation of vital physiological processes such as breathing and heart rate appears critically compromised?", "Is there evidence of profound sensory and motor deficits due to missing essential brain structures?", "Does the image suggest inadequate regulation of involuntary functions like blood pressure or digestion, indicating autonomic instability?", "Can you observe signs of impaired respiratory or cardiovascular regulation, such as respiratory failure or abnormal heart function?", "Is there an absence of normal reflexes or basic survival behaviors, possibly due to missing neural circuits in the brainstem or higher centers?", "Does the image indicate disruption of hormonal regulation or homeostasis, such as impaired hypothalamic or pituitary function?", "Can you see evidence of abolished movement coordination or postural instability, potentially due to absent cerebrum and cerebellum?", "Is there a complete lack of consciousness or cognitive function, as might be expected if the cerebral cortex is not developed?", "Does the image suggest a loss of communication between organ systems, possibly due to missing central neural pathways?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure within the nucleus that has a higher refractive index than the surrounding nucleoplasm?", "Is there typically one, but occasionally several, of these inclusions present within a single nucleus?", "Can you observe a nuclear inclusion that may contain viral proteins, cellular proteins, or nucleic acids such as DNA or RNA?"], "relational": ["Does the image show any intranuclear aggregates within the nuclei of cells?", "Can you see any nuclear changes in larger structures like the brain, liver, or skin?", "Do you observe inclusions in the nuclei of neurons, hepatocytes, or epithelial cells?"], "contexual_behavior": [], "functions": ["Can you identify a nuclear feature that might modulate gene expression by sequestering transcription factors or altering chromatin organization?", "Is there a visible nuclear structure that could alter the spatial distribution of nuclear components and influence nuclear dynamics?", "Can you identify a nuclear feature that may contribute to the pathogenesis of neurodegenerative disorders or viral infections by disrupting normal nuclear functions?"]}}}
[ { "answer": "frontal view close-up", "extracted_concepts": [], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "frontal view close-up", "image" ], "question": "does this image show frontal view close-up?" }, { "answer": "no", "extracted_concepts": [ "thecoma" ], "question": "does thecoma show frontal view close-up?" }, { "answer": "anencephaly and bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate", "anencephaly" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bilateral cleft palate", "anencephaly" ], "question": "is anencephaly and bilateral cleft palate present?" }, { "answer": "no", "extracted_concepts": [ "endometritis postpartum" ], "question": "is endometritis postpartum present?" }, { "answer": "anencephaly and bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate", "anencephaly" ], "question": "what is present?" } ]	["thecoma", "frontal view close-up", "image", "bilateral cleft palate", "anencephaly", "endometritis postpartum"]	{"thecoma": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a mass present that measures between 5 and 10 centimeters in diameter?", "Can you identify a structure that appears round or oval in shape?", "Does the image show a mass with a yellow to yellow-white coloration?", "Is there a solid lesion with a firm consistency visible?", "Can you see a structure that appears to have high lipid content, as suggested by its color?", "Is there evidence of moderate to abundant collagen forming part of the stromal matrix in any mass present?", "Does the image show a lesion with low vascularity?", "Can you identify a mass that appears to have a slow growth rate based on its features?", "Is there a structure that seems to have moderate to high stromal cell density?", "Does any mass appear to have a low nuclear-to-cytoplasmic ratio, with abundant cytoplasm in its cells?", "Is there a lesion where calcifications are rare or absent?", "Can you see a mass with moderate water content suggested by its appearance?", "Does the image show a lesion with minimal or absent cellular atypia?", "Is there a structure where the mitotic activity appears very low, with less than 1 mitosis per high power field?", "Can you identify a mass that might express markers such as inhibin, calretinin, or vimentin?", "Does the extracellular matrix of any lesion appear to be composed mainly of collagen fibers and lipid-rich stroma?", "Is there a mass that could be associated with elevated estrogen production based on its features?"], "relational": ["Does the image show a structure associated with the reproductive system?", "Is there a mass containing stromal or connective tissue visible?", "Can you identify a lesion adjacent to the ovarian cortex or follicles?", "Does the image reveal a structure arising from the ovarian stroma or medulla?", "Is there a mass located within the pelvic cavity?", "Can you see evidence of blood vessels such as the ovarian artery or vein supplying a lesion?", "Is there a structure interacting with ovarian follicles, corpus luteum, or the surface epithelium?", "Does the image contain cells resembling theca cells or spindle-shaped stromal cells?", "Can you identify supporting fibrous stroma or vascular connective tissue surrounding a mass within the ovary?"], "contexual_behavior": ["Is there a structure in the image that could be responsible for increased estrogen production, particularly in individuals of reproductive age?", "Can you identify an object whose hormone secretion appears reduced in postmenopausal individuals?", "Does the image show a feature that might impair ovarian function during menopause by disrupting hormone balance?", "Is there evidence of a structure whose growth rate could be influenced by elevated gonadotropin levels or hormone therapy?", "Can you see an area where sex steroid production might be diminished due to cellular degeneration or insufficient theca cell function?", "Is there a region that could display increased metabolic activity during pregnancy as a result of elevated circulating hormones?", "Does the image contain a structure whose functional activity might be decreased following chemotherapy?", "Is there an object that could contribute to abnormal uterine bleeding by stimulating the endometrial lining with excess estrogen?", "Can you identify a structure whose hormone production may be altered in the presence of other ovarian tumors due to local paracrine signaling?", "Is there evidence of impaired steroidogenesis in an aging individual, possibly due to reduced enzymatic activity or cellular senescence?", "Does the image show a structure that could play a role in endometrial stimulation through high levels of estrogen secretion?", "Can you see a region whose functional impact might be reduced after surgical removal or debulking of tumor tissue?", "Is there a structure that could alter its biological behavior in response to metabolic stress, such as hypoxia or nutrient deprivation?", "Does the image contain an object whose estrogenic activity might lead to endometrial hyperplasia under prolonged unopposed estrogen exposure?", "Can you identify a feature whose function may change during recurrence after initial treatment, possibly due to genetic alterations or changes in the tumor microenvironment?"], "functions": ["Does the image show an ovarian mass that could be involved in hormone production?", "Is there a structure present that might be classified as an ovarian neoplasm?", "Can you identify a lesion that could be responsible for increased steroid hormone secretion, especially estrogen?", "Is there evidence of a tumor that may cause estrogen overproduction?", "Does the image contain a mass that could disrupt normal ovarian function or alter the ovarian environment?", "Can you see a structure that might be linked to hormonal imbalance or endocrine disruption?", "Is there a lesion that could regulate biological processes such as endometrial proliferation or menstrual cycle modulation?", "Does the image suggest the presence of a mass that could cause menstrual irregularities or abnormal uterine bleeding?", "Can you identify features consistent with endometrial hyperplasia or thickening, possibly due to increased estrogen levels?", "Is there a structure that might suppress other reproductive hormones by elevating estrogen?", "Does the image show a mass that could influence ovulation, fertility, or endometrial receptivity?", "Can you see evidence of stromal proliferation or compression of normal ovarian tissue adjacent to a mass?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an object that might contain two to five distinct cell types?", "Is there a structure that could be responsible for releasing growth hormone or adrenaline?", "Can you see a gland with a soft, friable texture?"], "relational": ["Does the image show a structure that could be the pituitary gland, thyroid gland, adrenal gland, pancreas, pineal gland, parathyroid gland, ovaries, or testes?", "Does the image show a gland that influences target organs through feedback loops?", "Can you identify a structure that is ductless and releases substances directly into the blood?"], "contexual_behavior": [], "functions": ["Is there a visible feature associated with the stress response, such as the adrenal glands?", "Is there evidence of a gland or tissue participating in negative feedback or hormonal control?", "Does the image show any features that could influence mood or behavior via hormone action on the brain?"]}}, "frontal view close-up": {"yes_questions": {"contexual_properties": ["Does the image show any evidence of swelling that could indicate underlying inflammation or trauma?", "Can you observe discoloration that might suggest bruising or hyperpigmentation?", "Is there any area with abnormal texture, such as roughness or nodules, visible in the image?", "Does the image reveal any asymmetry that could be due to edema or the presence of masses?", "Can you see increased redness that might be associated with erythema or infection?", "Are there any visible lesions or spots that could indicate acne or petechiae?", "Does the image show puffiness that might be related to fluid retention or periorbital edema?", "Can you observe any changes in skin tone, such as hypopigmentation or jaundice?", "Is there evidence of abnormal surface features like scars or ulcers present in the image?", "Does the image display visible edema suggesting accumulation of interstitial fluid in facial tissues?", "Are there changes in facial contour that could be caused by masses, swelling, or atrophy?", "Can you identify any abnormal growths, such as nevi or tumors, on the skin?", "Does the image show increased oiliness or dryness that might indicate sebaceous gland disorders or xerosis?", "Is there visible scaling or flaking that could be due to dermatitis, psoriasis, or eczema?", "Can you see any signs of bruising that might result from subcutaneous bleeding or facial trauma?"], "properties": ["Does the image display a region with a narrow field of view, such as a face or a specific anatomical area?", "Can you identify an image with a resolution commonly found in high-detail close-ups, such as 1920x1080 or 2048x1536 pixels?", "Is there evidence of magnification in the range of 1x to 2x in the image?", "Does the image appear to use true color with a color depth of 24 bits?", "Can you estimate if the image file size is likely between 2 and 5 megabytes based on its detail and quality?", "Is the aspect ratio of the image consistent with standard values like 4:3 or 16:9?", "Does the brightness of the image seem to fall within the range of 150 to 250 cd/m\u00b2?", "Can you observe a contrast ratio that would be typical for close-up images, such as between 1000:1 and 3000:1?", "Does the image have a pixel density that appears to be in the range of 200 to 400 pixels per inch?", "Is the image presented in a standard format such as JPEG, PNG, or TIFF?"], "relational": ["Does the image display the anterior region of the body or head?", "Are the eyes, nose, mouth, or forehead clearly visible from the front?", "Can you identify features belonging to the integumentary or musculoskeletal systems in the image?", "Is there a view that allows for observation of the skin, eyes, or nasal structures?", "Are tissues such as the epidermis, dermis, subcutaneous tissue, or facial muscles apparent in the image?", "Is the orientation of the structures consistent with the coronal (frontal) anatomical plane?", "Are the forehead, cheeks, lips, or chin visible from a frontal perspective?", "Can you locate anatomical landmarks such as the glabella, nasion, or infraorbital margin?", "Are the lateral cheeks, temples, or jawline present at the borders of the depicted area?", "Are the posterior head, neck, or ears excluded from the visible region in the image?"], "contexual_behavior": ["Does the image show reduced visibility of anatomical landmarks due to swelling or inflammation?", "Can you observe altered facial symmetry that might suggest an acute neurological event?", "Is there evidence that poor lighting conditions are limiting the ability to assess skin coloration?", "Does the image enhance the visibility of vascular patterns, possibly indicating facial erythema or edema from an allergic reaction?", "Can you detect impaired movement of facial muscles that could be related to nerve palsy or facial nerve paralysis?", "Is there reduced clarity of facial contours, potentially caused by tissue swelling or edema?", "Does the image reveal changes in facial expression or muscle tone that could be associated with emotional stress?", "Can you see alterations in tissue texture, such as swelling, redness, or disruption of the skin surface, that might result from infection or trauma?", "Is the detection of subtle skin lesions diminished due to the presence of excessive facial hair?", "Does the image provide enhanced visualization of abnormal facial movements, such as twitching or grimacing, that could occur during seizure activity?"], "functions": []}, "no_questions": {"contexual_properties": [], "properties": ["Are there cells with cytoplasm that appears rich in ribosomes but contains few other organelles?", "Is there evidence of cells with moderate to high proliferation, which may be more prominent during liver injury?", "Are there cells present that express markers associated with progenitor or biliary lineages?"], "relational": ["Does the image show a population of cells related to hepatocytes, cholangiocytes, or hepatic stellate cells?", "Does the image show cells located within the hepatic system?", "Can you identify progenitor cells that may be found alongside hepatic or biliary progenitor cells?"], "contexual_behavior": [], "functions": ["Is there evidence of cell populations contributing to the replacement of damaged liver tissue?", "Can you identify cells that might be differentiating into hepatocytes or cholangiocytes?", "Does the image contain cells that could be supporting liver function during disease by generating new functional cells?"]}}, "image": {"yes_questions": {"contexual_properties": ["Does the image contain areas where features are difficult to distinguish due to reduced clarity, possibly from loss of focus or motion?", "Can you observe regions where the difference between light and dark areas is minimal, making structures hard to see?", "Is there evidence of altered proportions of primary colors, suggesting a change in color balance or white balance?", "Are there parts of the image where individual pixels are visible, indicating insufficient resolution for the display size?", "Do you notice random variations in brightness or color that could indicate increased noise, perhaps from high sensor sensitivity or low light?", "Is there a loss of fine detail that might be due to decreased pixel density or overall resolution?", "Are there areas that appear excessively bright, with loss of detail, suggesting overexposure?", "Does the image contain regions that are unusually dark, with lost detail, possibly due to underexposure?", "Can you see any unwanted visual elements or irregularities that might be artifacts from technical limitations or processing errors?", "Are there places where edges and fine details are less defined, indicating a loss of sharpness?", "Is there any visible alteration in geometric proportions, such as bending or stretching, that could be due to distortion or lens aberration?", "Do you observe regions where the overall luminance is abnormally high or low, suggesting abnormal brightness?", "Are there areas where the intensity of colors appears unusually high or low, indicating altered saturation?", "Can you spot repetitive or unexpected patterns that might result from technical faults or interference?", "Are there shadows present in locations that do not correspond to the expected direction of illumination?", "Is there a noticeable loss of fine structures or details, possibly due to compression, low resolution, or blurring?", "Does the image have a coarse or grainy texture, especially in low-light areas, indicating high noise levels?", "Are there regions where the colors appear reversed, as in a negative image, possibly due to processing errors?", "Do you see areas where the difference between light and dark is exaggerated, making features more pronounced than usual?", "Are there unexpected spots or marks present, which could be due to sensor defects, dust, or artifacts?"], "properties": ["Can you identify an object whose resolution is defined by the number of pixels along its width and height?", "Is there an entity present whose file size would depend on its resolution, color depth, and compression?", "Does the scene include something characterized by a color depth such as 8-bit or 24-bit?", "Can you find an object with an aspect ratio like 4:3 or 16:9?", "Is there a structure whose width in pixels could be specified as 800, 1920, or 3840?", "Can you see something whose height in pixels might be 600, 1080, or 2160?", "Is there an entity that could be stored in formats such as JPEG, PNG, or TIFF?", "Can you identify an object with a bit depth per channel of 8 bits, 12 bits, or 16 bits?", "Is there something whose compression ratio might range from 2:1 to 20:1 depending on its format?", "Can you observe an entity whose average brightness level could be measured on a scale from 0 (black) to 255 (white)?", "Does the scene include something whose contrast level is defined by the difference between its darkest and brightest areas?", "Is there an object whose dynamic range could be expressed in stops or decibels?", "Can you find something with a pixel density measured in dots per inch, such as 72, 150, or 300 DPI?", "Is there an entity that uses a color space like sRGB, Adobe RGB, or CMYK?", "Can you see an object whose noise level could be quantified by signal-to-noise ratio or noise variance?"], "relational": ["Does the image display any structures that could be classified as bones or muscles?", "Can you identify features belonging to the skeletal or cardiovascular systems?", "Is there evidence of anatomical regions such as the thorax or abdomen in the image?", "Does the image show tissues like connective or nervous tissue?", "Can you observe spatial orientation or continuity between anatomical structures?", "Are there cells visible that resemble neurons or adipocytes?", "Does the image include structures adjacent to major blood vessels or ligaments?", "Can you determine if the image is oriented along the sagittal or transverse plane?", "Is there a visible organ such as the heart or kidneys in the image?", "Can you identify anatomical features at the tissue or cellular level?", "Does the image show proximity or overlap between neighboring organs?", "Are muscle tissue and epithelial tissue both present in the image?", "Can you see anatomical relationships that suggest the presence of surrounding tissues?", "Is the head or limbs region represented in the image?", "Does the image capture multiple hierarchical levels, such as both organs and tissues?"], "contexual_behavior": ["Does the image show any signs of reduced clarity or sharpness that could compromise diagnostic interpretation?", "Are there visible artifacts suggesting patient movement that might obscure anatomical details?", "Can you identify the use of contrast agents enhancing the visibility of specific tissues or lesions?", "Does the image appear to have been acquired using advanced techniques such as high-resolution MRI or PET, potentially improving sensitivity for disease detection?", "Is there evidence of low resolution that could limit the detection of subtle anatomical changes important for disease monitoring?", "Does the image suggest challenges in clarity or depth that might be encountered in obese patients during image-guided interventions?", "Can you determine which imaging modality was used, and does it provide unique contrast for differentiating tissue types?", "Is there evidence of 3D reconstruction that enhances spatial orientation and anatomical detail for surgical planning?", "Does the image quality suggest a high or low signal-to-noise ratio, potentially affecting the detection of small structures such as microcalcifications?", "Are there features in the image that highlight metabolic or physiological activity, aiding in tumor localization?", "Is there anatomical overlap present that could obscure regions of interest and compromise diagnostic function?", "Does the image appear to be part of a screening program where patient age or risk factors might influence disease detectability?", "Can you observe the effects of image enhancement processing, such as increased contrast or reduced artifacts, that might improve interpretation?", "Is there evidence of metallic implants causing artifacts that could obscure underlying tissues and hinder early disease detection?", "Does the image include dynamic contrast features that enable visualization of blood flow or vessel patency for vascular assessment?", "Are there motion artifacts present that could reduce the reliability of image-based measurements?", "Can you identify the fusion of information from multiple imaging modalities that might improve diagnostic function?", "Is anatomical visualization sufficient to guide a biopsy, or does poor visualization make target localization difficult?", "Does the image suggest it is being used for therapy monitoring during rapid disease progression, possibly requiring advanced or frequent imaging?", "Are there indications that specific radiotracers were used to enhance the detection of inflammation?"], "functions": ["Does the image provide visualization of internal anatomical structures?", "Can you identify any documentation of clinical findings within the image?", "Is there evidence in the image that could support clinical decision-making?", "Does the image reveal any pathological changes or abnormal findings?", "Can you use the image to aid in disease diagnosis by identifying abnormalities?", "Is there information in the image that could be used to monitor disease progression over time?", "Does the image allow for serial comparison to assess changes in anatomy or function?", "Can the image be used to support treatment planning by localizing lesions or mapping anatomy?", "Is there anatomical detail in the image that would help in targeting areas for intervention?", "Does the image provide real-time visualization or navigation of anatomical landmarks for surgical guidance?", "Can you use the image to detect anatomical abnormalities by assessing structure or function?", "Is there evidence in the image that could be used for organ function assessment, such as functional imaging features?", "Does the image contain information relevant to physiological evaluation of an organ?", "Can the image be used for disease screening or early detection of asymptomatic conditions?", "Is there visual evidence in the image that could facilitate preventive imaging?", "Does the image allow for assessment of therapy response by comparing pre- and post-treatment findings?", "Can you use the image to monitor treatment outcomes or evaluate changes in disease status?", "Is there information in the image that could facilitate image-guided minimally invasive procedures?", "Does the image provide visualization that would assist in procedural navigation during interventions?"]}, "no_questions": {"contexual_properties": ["Is there a change in surface texture, such as irregularity or fibrosis, on any visible mass?", "Can you identify areas that might represent calcification within a mass, possibly due to mineral deposition?", "Is there a mass that appears encapsulated, possibly as a result of a host response to limit its spread?"], "properties": ["Is there a region composed of densely packed cells, including possible immune or stromal cells?", "Can you identify features that might be associated with mutations in oncogenes, tumor suppressor genes, or DNA repair genes?", "Can you identify an area where tumor marker expression might be elevated, such as CEA, AFP, or PSA?"], "relational": ["Can you observe anatomical barriers, such as basement membranes or organ capsules, that appear disrupted or breached?", "Does the image reveal a structure that appears to invade blood vessels, lymphatic vessels, or adjacent organs?", "Does the image show a structure that disrupts surrounding tissues through invasion, compression, or destruction?"], "contexual_behavior": ["Is there evidence of evasion of programmed cell death, possibly due to genetic alterations in regulators like TP53 or BCL-2?", "Is there evidence of altered cell signaling pathways, such as activation of NF-\u03baB or STAT3, in regions affected by chronic inflammation?", "Can you identify a region that appears resistant to immune cell infiltration, suggesting upregulation of immune checkpoint molecules or reduced antigen presentation?"], "functions": ["Does the image suggest the presence of cells that have intravasated into blood or lymphatic vessels, potentially indicating spread to distant sites?", "Is there evidence of dedifferentiation or the presence of cells with stem-like characteristics, such as poorly differentiated or undifferentiated cell clusters?", "Can you see features that might indicate evasion of programmed cell death, such as dense clusters of abnormal cells persisting despite tissue damage?"]}}, "bilateral cleft palate": {"yes_questions": {"contexual_properties": ["Does the image show a palatal gap that appears wider than usual, possibly indicating a pre-surgical or growing state?", "Can you observe a deepened separation in the palate that might result from vertical growth of the maxilla during childhood?", "Is there evidence of significant tissue deficiency in the palatal region, suggesting a preoperative or delayed repair condition?", "Do you see abnormal tissue characteristics, such as irregular surfaces, that could be associated with chronic inflammation or infection?", "Is there a palatal defect that appears more pronounced, possibly reflecting a period of rapid craniofacial growth without surgical intervention?", "Can you identify areas of redness or purplish discoloration in the palate, which may indicate infection or inflammation?", "Is there visible scar tissue in the palatal region, suggesting previous surgical repair?", "Do you notice swelling in the palate that could be due to recent surgery or acute infection?", "Is the palatal gap visibly reduced, possibly indicating a successful surgical intervention?", "Can you detect the presence of fluid or exudate in the palatal area, which might be due to infection, inflammation, or fistula formation?", "Are there any ulcerations or open sores in the palate that could result from trauma, infection, or poor oral hygiene?", "Do you see abnormal mucosal texture, such as roughness or irregularity, possibly due to repeated infections, scarring, or failed repairs?", "Is the palatal separation less apparent, potentially reflecting tissue remodeling after surgical repair and aging?", "Can you observe signs of bleeding in the palatal region, which may occur during surgery, trauma, or acute infection?", "Is there a visible fistula or abnormal opening in the palate, possibly indicating a postoperative complication or incomplete healing?"], "properties": ["Is there a structure in the image that shows a gap measuring between 5 and 20 millimeters in width?", "Can you identify a separation extending from the incisive foramen to the uvula, with a length of approximately 20 to 40 millimeters?", "Does the image display a shallow to moderate depression, with a depth between 2 and 8 millimeters, in the palatal region?", "Is there a visible V-shaped or U-shaped gap along the midline of the palate?", "Can you see a midline defect affecting both the hard and soft palate symmetrically?", "Does the image show a structure with a frequency of occurrence in live births between 0.02 and 0.05 percent?", "Is there tissue present that appears pink to reddish, possibly with areas of erythema, in the palatal region?", "Can you identify disrupted mucosa, connective tissue, or exposed bone or cartilage within a palatal gap?", "Does the image reveal a complete separation between the palatal shelves, with no fusion at the midline?", "Is there an area where the palatal tissue thickness is reduced to less than 2 millimeters?", "Can you observe an irregular or uneven surface texture, possibly with ulcerations or granulation tissue, in the palate?", "Is there evidence of bony defects in the palatal region, given that such defects are present in more than 90 percent of similar cases?", "Does the image show involvement of both the hard and soft palate, with the hard palate nearly always affected and the soft palate in most cases?", "Can you see discontinuity or compromised integrity of the mucosa, with exposure of underlying structures in the palate?", "Is the distance between two cleft margins in the palatal region within the range of 5 to 20 millimeters?"], "relational": ["Does the image show a disruption involving both the hard and soft regions forming the roof of the oral cavity?", "Can you identify a gap or separation affecting the midline and lateral aspects of the palatal shelves?", "Is there evidence of interrupted continuity in the maxilla or palatine bones within the oral cavity?", "Does the image reveal separation of the mucosal, muscular, and bony layers of the palate?", "Can you observe a defect indicating failure of fusion between the palatal processes of the maxilla?", "Is there a visible abnormality that could impact muscles such as the levator veli palatini or tensor veli palatini?", "Does the image show a structure adjacent to the nasal septum, upper lip, or lateral nasal wall that appears disrupted?", "Are the anatomical boundaries from the alveolar ridge to the uvula and lateral palatal shelves visibly altered?", "Can you detect additional anomalies such as a cleft in the upper lip, irregular dental development, or nasal deformities?", "Is there an abnormal opening between the oral and nasal cavities that could affect speech or feeding?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structural defect that could allow food or liquids to pass from the mouth into the nasal cavity, potentially leading to nasal regurgitation?", "Is there a visible abnormal communication between the oral and nasal spaces that might disrupt normal swallowing or oropharyngeal coordination?", "Can you identify a feature that could prevent proper closure of the velopharyngeal port, possibly resulting in hypernasal speech or articulation difficulties?", "Does the image suggest a condition that would make it difficult for an infant to create suction during feeding, potentially leading to poor intake or prolonged feeding times?", "Is there a structural abnormality that could compromise airway protection during eating or drinking, increasing the risk of aspiration or choking?", "Can you see an oronasal fistula or palatal defect that disrupts the normal separation between the oral and nasal cavities?", "Does the image show a feature that might alter nasal airflow or increase the likelihood of airway obstruction, possibly causing breathing difficulties?", "Is there evidence of a defect that could reduce the ability to generate intraoral pressure, affecting effective sucking, swallowing, or speech sound production?", "Can you identify a structural issue that might impair Eustachian tube function, increasing the risk of recurrent ear infections or middle ear effusion?", "Does the image suggest disturbances in facial growth or dental alignment, such as maxillary deficiency or malocclusion?", "Is there any indication that the individual may have developed compensatory mechanisms, such as atypical speech articulation or altered swallowing patterns, to adapt to a structural defect in the palate?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there abnormality in lymphoid structures such as lymph nodes, thymus, or spleen?", "Is there infiltration of tissues like bone marrow, lymph nodes, spleen, or the central nervous system visible?", "Does the image suggest disruption of normal hematopoiesis within the bone marrow?"], "contexual_behavior": [], "functions": ["Can you identify signs of reduced red blood cell production, such as features suggestive of anemia?", "Can you see an accumulation of nonfunctional lymphoid cells that do not appear to participate in immune responses?", "Does the image show decreased platelet numbers or features consistent with impaired blood clotting?"]}}, "anencephaly": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show an individual with a markedly reduced cranial size compared to normal?", "Is there evidence of microcephaly or a head circumference far below the expected range for gestational age?", "Can you identify a case where the cranial vault appears absent or severely underdeveloped, potentially exposing underlying tissue?", "Is there visible neural tissue that appears dark red to purple and has a friable, gelatinous texture?", "Does the image reveal disorganized or incomplete remnants of forebrain and midbrain structures?", "Can you see exposed neural tissue with a disorganized appearance and absence of the cerebrum?", "Is there a near-complete absence of skull bones in the cranial region?", "Does the brain tissue volume appear severely diminished, possibly limited to rudimentary brainstem structures?", "Is there evidence of malformed brainstem or primitive neural elements with no visible cerebral hemispheres?", "Can you infer from the image that the brain weight would likely be significantly below normal, possibly less than 100 grams?"], "relational": ["Does the image show absence or severe malformation of major structures such as the cerebral hemispheres or cranial vault?", "Is there a region of the head where the scalp appears missing or abnormal?", "Can you identify abnormalities affecting the forebrain or midbrain regions?", "Does the image reveal missing parts of the brain such as the cerebral cortex or cerebrum?", "Is there evidence of absent or malformed diencephalon in the cranial area?", "Are the bones of the skull or meninges visibly absent or disrupted?", "Can you see areas where neural tissue is exposed or not covered by cranial bone or skin?", "Is there a failure of cranial bone or overlying ectoderm development visible in the image?", "Does the image suggest a disruption in neural tube closure, particularly at the anterior end?", "Are there visible abnormalities in both the nervous and integumentary systems of the head?", "Can you identify regions where embryological structures such as the neural plate or neural folds may have failed to develop properly?", "Is the interface between the brain and skull altered, with evidence of exposed neural tissue?", "Does the upper facial region or calvaria appear structurally abnormal or incomplete?", "Is there a lack of normal scalp covering the cranial region?", "Are the skull bones missing or severely underdeveloped in the cranial area?"], "contexual_behavior": ["Does the image show evidence of a neural tube defect affecting the development of brain structures during early embryogenesis?", "Can you identify a fetus with malformation or absence of major brain regions that would disrupt central autonomic control?", "Is there a visible absence or severe underdevelopment of the forebrain and cerebrum, suggesting reduced neural control of vital physiological processes?", "Does the image indicate impaired coordination of fetal movement due to missing or underdeveloped motor cortex and neural circuits?", "Can you observe signs of failed sensory processing in the fetus, possibly due to missing sensory relay centers in the brain?", "Is there evidence of disrupted signaling between the brain and other organs, as might occur if neural pathways for inter-organ communication are absent?", "Does the image suggest abnormal regulation of heart rate or respiration that could result from a malformed or absent brainstem?", "Can you see indications that hypothalamic or pituitary structures have failed to develop, potentially affecting neurohormone production?", "Is there a decreased capacity for reflex responses in the fetus, possibly due to incomplete or absent neural circuits in the brain?", "Does the image show a lack of integration of neural pathways necessary for survival after birth, as would be expected if critical brain regions are missing?"], "functions": ["Does the image show an individual with severe malformation of the brain, particularly lacking the cerebral hemispheres and forebrain?", "Can you identify a case where neural regulation of vital physiological processes such as breathing and heart rate appears critically compromised?", "Is there evidence of profound sensory and motor deficits due to missing essential brain structures?", "Does the image suggest inadequate regulation of involuntary functions like blood pressure or digestion, indicating autonomic instability?", "Can you observe signs of impaired respiratory or cardiovascular regulation, such as respiratory failure or abnormal heart function?", "Is there an absence of normal reflexes or basic survival behaviors, possibly due to missing neural circuits in the brainstem or higher centers?", "Does the image indicate disruption of hormonal regulation or homeostasis, such as impaired hypothalamic or pituitary function?", "Can you see evidence of abolished movement coordination or postural instability, potentially due to absent cerebrum and cerebellum?", "Is there a complete lack of consciousness or cognitive function, as might be expected if the cerebral cortex is not developed?", "Does the image suggest a loss of communication between organ systems, possibly due to missing central neural pathways?"]}, "no_questions": {"contexual_properties": ["Can you see a structure that looks cloudy, potentially due to deposition of insoluble materials or surface etching?", "Does the image contain an object with contents that have increased in volume, possibly from gas evolution, heating, or addition of reagents?", "Can you see contents that have changed color, perhaps due to a chemical reaction, pH shift, or indicator use?"], "properties": ["Is there a structure that could weigh between 10 grams and 20 grams when empty?", "Is there an object present that could have a volume capacity between 5 mL and 50 mL?", "Does the image show an object with a smooth, flared rim?"], "relational": ["Does the image show a device like a needle, syringe, or transfer pipette being used to transfer a specimen into a small cylindrical container?", "Is there a structure that could be placed in a centrifuge for sedimentation or separation by centrifugal force?", "Does the image show an object commonly used in clinical chemistry or hematology procedures?"], "contexual_behavior": ["Can you identify a vessel whose function in maintaining sample stability could be affected by rapid temperature changes, potentially causing condensation or denaturation?", "Is there a container whose effectiveness in preventing evaporation might be reduced in a low humidity environment, leading to sample loss?", "Does the image show an item whose capacity to support cell culture would decrease if its surface integrity were compromised by poor storage conditions?"], "functions": []}}, "endometritis postpartum": {"yes_questions": {"contexual_properties": ["Does the image show evidence of a thickened uterine lining during the period following childbirth?", "Is there visual indication of an enlarged uterus that could be due to inflammation and edema after delivery?", "Can you identify abnormal uterine discharge, such as purulent or malodorous lochia, in the postpartum context?", "Does the endometrial tissue appear edematous, suggesting an active inflammatory response after parturition?", "Is there any sign of tissue friability or disruption of endometrial integrity in the postpartum uterus?", "Can you observe features consistent with purulent lochia, indicating pus formation within the uterine cavity?", "Is there evidence of necrosis or tissue death in the endometrial lining, possibly due to severe infection?", "Does the uterus appear tender or sensitive to palpation, suggesting ongoing inflammation?", "Are there visual signs of microabscesses or localized collections within the endometrial tissue?", "Can you detect increased vascularity or hyperemia in the uterine lining, consistent with a vascular response to inflammation?", "Is there evidence of inflammatory infiltrates within the endometrial tissue, as might be seen during infection?", "Does the image reveal abnormal endometrial thickness, which could be associated with inflammation or retained products after childbirth?"], "properties": [], "relational": ["Does the image show evidence of inflammation in a structure belonging to the female reproductive system following childbirth?", "Can you identify an area where the endometrial lining appears altered or inflamed?", "Is there visible edema or leukocyte infiltration in the tissue lining the inside of a pelvic organ?", "Does the image display changes in the myometrial layer adjacent to the endometrial lining?", "Can you see any abnormalities at the site where the placenta was previously attached?", "Is there evidence of involvement of the cervix, vagina, or fallopian tubes in the inflammatory process?", "Does the image show any impact on surrounding pelvic structures such as the parametrium, broad ligament, or ovaries?", "Are there visible changes in the blood vessels supplying the affected area, such as the uterine or ovarian arteries?", "Can you observe any anatomical barriers, like the peritoneum or broad ligament, that might limit the spread of inflammation?", "Is there any indication of infection or inflammation at the decidual tissue within the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show evidence of impaired function in a reproductive organ following childbirth?", "Is there visual indication of inflammation or tissue damage in the uterine area after delivery?", "Can you identify signs of delayed healing or abnormal tissue remodeling in the uterus postpartum?", "Does the image suggest increased bleeding or poor contractility in the uterine tissue?", "Is there evidence of abnormal discharge or impaired regeneration of the endometrial lining?", "Can you see signs that suggest infection may have spread to adjacent pelvic tissues or the bloodstream?", "Does the image indicate possible uterine scarring or features that could reduce fertility in future pregnancies?", "Is there visual evidence of increased leukocyte infiltration or heightened immune activity in the uterine tissue?", "Can you identify features that suggest prolonged postpartum symptoms or the need for medical intervention?", "Does the image show signs of uterine atony or retention of lochia indicating impaired expulsion of postpartum material?"]}, "no_questions": {"contexual_properties": ["Can you detect loss of normal anatomical structure that could be due to destruction or distortion from trauma, infection, or malignancy?", "Does the image show any abnormal soft tissue or bone growths that might represent a mass or tumor?", "Is there evidence of tissue swelling, such as increased soft tissue volume from inflammation, trauma, or infection?"], "properties": ["Are there visual differences that could be explained by an attenuation coefficient of 0.2 to 0.5 per centimeter in bone?", "Can you identify visual characteristics that suggest the use of electromagnetic waves with frequencies between 3 \u00d7 10^16 and 3 \u00d7 10^19 hertz?", "Is there evidence that the current used in the imaging process was between 1 and 500 milliamperes?"], "relational": ["Is there a body part, such as the hand, foot, or pelvis, positioned specifically for examination?", "Can you identify regions like the chest, abdomen, or limbs being examined?", "Is there evidence of tissues with varying densities, such as bone, air-filled spaces, or soft tissue?"], "contexual_behavior": ["Does the image appear to have difficulty revealing soft tissue abnormalities that might be present in early stages of disease?", "Can you identify pulmonary changes, such as consolidation or infiltrates, that would become more apparent in the setting of pneumonia?", "Is there enhanced detection of radiopaque calcifications that might be associated with chronic kidney disease?"], "functions": ["Is there an abnormal mass, lesion, or calcification present that could suggest malignancy?", "Is there a radiopaque object visible that could represent a foreign body within tissues or organs?", "Does the image provide visual information that could assist in diagnosing internal body structures?"]}}}
[ { "answer": "fixed tissue saggital section stenotic foramen magnum", "extracted_concepts": [ "stenotic foramen magnum", "saggital section", "fixed tissue" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "stenotic foramen magnum", "saggital section", "fixed tissue" ], "question": "does this image show fixed tissue saggital section stenotic foramen magnum?" }, { "answer": "no", "extracted_concepts": [ "stenotic foramen magnum", "saggital section", "fixed tissue", "mesothelioma" ], "question": "does mesothelioma show fixed tissue saggital section stenotic foramen magnum?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "embryo-fetus" ], "question": "is embryo-fetus present?" }, { "answer": "rheumatoid arthritis", "extracted_concepts": [ "rheumatoid arthritis" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "rheumatoid arthritis" ], "question": "is rheumatoid arthritis present?" }, { "answer": "no", "extracted_concepts": [], "question": "is exact cause present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone , calvarium present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "rheumatoid arthritis", "extracted_concepts": [ "rheumatoid arthritis" ], "question": "what is present?" } ]	["embryo-fetus", "bone", "rheumatoid arthritis", "saggital section", "stenotic foramen magnum", "calvarium", "fixed tissue", "mesothelioma"]	{"embryo-fetus": {"yes_questions": {"contexual_properties": ["Does the image show evidence of growth or size increase consistent with prenatal development stages?", "Is there visual indication of a decrease in growth rate, such as smaller-than-expected size for late gestation?", "Can you identify any structural abnormalities that might suggest congenital anomalies or developmental disruptions?", "Is there visible abnormal fluid accumulation, such as generalized edema, that could indicate hydrops fetalis or fetal anemia?", "Does the image suggest rapid weight gain or growth spurts typical of the second or third trimester?", "Are there signs of organ enlargement that might be associated with metabolic disorders or congenital infections?", "Can you observe abnormal tissue composition that could result from genetic diseases or intrauterine injury?", "Is there evidence of abnormal limb length or proportions that might indicate skeletal dysplasia or a growth disorder?", "Do you see any signs of edema that could be related to cardiac failure or lymphatic obstruction?", "Is there an abnormal head circumference, such as microcephaly or macrocephaly, suggesting neurodevelopmental disorders?", "Are there visible tissue calcifications that could be due to congenital infections or metabolic disturbances?", "Does the image show abnormal skin color that might be associated with anemia, hypoxia, or a genetic syndrome?", "Is there an excessive amount of amniotic fluid present, suggesting polyhydramnios due to gastrointestinal obstruction or maternal diabetes?", "Can you detect signs of body mass loss that might indicate intrauterine growth restriction or placental insufficiency?", "Are there abnormalities in bone density that could be consistent with skeletal dysplasia or metabolic bone disease?", "Do you observe changes in organ size, such as hypoplasia or hypertrophy, compared to expected developmental norms?", "Is there an abnormal heart size that could suggest congenital heart disease or cardiomyopathy?", "Are cystic structures present that might be associated with genetic syndromes or developmental anomalies?", "Can you infer abnormal cell counts from features such as pallor or petechiae, which might indicate hematologic disorders or bone marrow dysfunction?", "Is there evidence of altered tissue elasticity, such as increased swelling or laxity, that could be related to connective tissue disorders or edema?"], "properties": ["Can you identify a structure whose length or size might indicate its developmental stage, ranging from a few millimeters to about half a meter?", "Is there an object whose weight could vary from less than a gram to several kilograms depending on its maturity?", "Does the image show a structure with a crown-rump length that could be used to estimate its developmental stage?", "Can you observe a form whose head circumference might increase from a few centimeters to over thirty centimeters as it matures?", "Is there a visible entity whose overall shape transitions from a curved, C-like form to a more human appearance as development progresses?", "Does the image contain a structure that might have a heart rate between 110 and 160 beats per minute?", "Can you see limbs whose length could range from a few millimeters to over twenty centimeters, depending on the stage of growth?", "Is there an object that likely has a high water content, possibly around 85\u201390% in early stages and decreasing as it matures?", "Can you identify a structure whose body temperature might be slightly lower than that of an adult human, around 37\u00b0C?", "Does the image show an entity that could have an oxygen saturation level between 50% and 70% due to placental gas exchange?", "Is there a visible structure whose skin color might change from translucent or reddish in early development to pinkish or light brown near maturity?", "Can you observe an object whose cell number could range from a few hundred to trillions as it develops?", "Is there a structure that would have low fat content early on, increasing to about 16% of its body weight by the end of development?", "Can you see a form whose tissues might contain about 15\u201320% protein by wet weight near maturity?", "Does the image contain a structure whose brain volume could increase from less than 1 cm\u00b3 to several hundred cm\u00b3 as it matures?", "Is there an object whose blood pH would typically be between 7.25 and 7.35?", "Can you identify a structure with bone density that increases over time, starting low and reaching up to 0.5 g/cm\u00b3 as ossification progresses?", "Does the image show an entity whose bones might accumulate more calcium and phosphorus, especially in later stages of development?", "Is there a visible structure whose blood glucose level could be between 20 and 60 mg/dL?", "Can you observe an object whose body fluids are characterized by high water content, electrolytes, proteins, and minimal fat in early development?"], "relational": ["Does the image show a structure that could be in either the embryonic or fetal period of development?", "Can you identify features such as a neural tube, heart tube, or limb buds in the image?", "Is there evidence of developing organ systems like the nervous, cardiovascular, or musculoskeletal systems?", "Does the image contain tissues that could be derived from ectoderm, mesoderm, or endoderm?", "Can you see a structure that is physically or functionally associated with the placenta for nutrient or gas exchange?", "Is there a visible membrane such as the amnion, chorion, or yolk sac surrounding a central structure?", "Does the image show a connection to maternal tissues, such as an umbilical cord or placental villi?", "Is the central structure located within a cavity like the amniotic or chorionic cavity?", "Are there prominent features in the head region, neural tube, or heart primordium visible in the image?", "Can you identify regions that suggest hierarchical derivation from the three germ layers?"], "contexual_behavior": ["Is there evidence of impaired organ formation that could be linked to nutrient deficiency during early development?", "Can you identify signs of growth restriction that might result from low oxygen levels at later stages of gestation?", "Does the image suggest reduced cell proliferation that could be associated with exposure to harmful substances during early organ formation?", "Is there visual indication of increased metabolic activity consistent with rapid growth phases in mid to late gestation?", "Can you observe features that might indicate abnormal neural tube closure, possibly due to folate deficiency in early pregnancy?", "Is there evidence of immune system immaturity that could be associated with preterm birth before 37 weeks?", "Does the image show signs of decreased nutrient uptake that might result from placental dysfunction, especially in mid to late pregnancy?", "Can you identify features suggesting altered hormone production, such as increased cortisol, in response to maternal stress during mid to late gestation?", "Is there visual evidence of impaired cardiac function that could be related to congenital heart disease from mid-gestation onward?", "Does the image indicate increased red blood cell production, possibly as a response to anemia during periods of high oxygen demand?", "Can you observe signs of reduced waste elimination that might be due to placental insufficiency, especially in late gestation?", "Is there evidence of disrupted fluid balance, such as decreased amniotic fluid volume, that could be associated with oligohydramnios in mid to late pregnancy?", "Does the image suggest advanced lung maturation, potentially as a result of maternal corticosteroid administration in anticipation of preterm delivery?", "Can you identify features of impaired bone mineralization that might be due to vitamin D deficiency during periods of rapid skeletal growth?", "Is there visual evidence of altered growth trajectory that could be linked to intrauterine infection, particularly in early to mid gestation?", "Does the image show signs of reduced brain development that might result from chronic maternal hypoglycemia during periods of rapid neurodevelopment?", "Can you observe features suggesting increased insulin production in response to maternal diabetes during mid to late gestation?", "Is there evidence of abnormal immune tolerance that could be associated with maternal-fetal incompatibility in mid to late pregnancy?", "Does the image indicate decreased movement that might result from uterine constraint, especially in late gestation?", "Can you identify signs of altered metabolic rate that could be due to maternal fasting, particularly in late pregnancy?"], "functions": ["Does the image show a structure undergoing processes like cell proliferation or morphogenesis?", "Can you identify an entity where gene regulation or signaling pathways might be actively controlling growth?", "Is there evidence of organ primordia or early organ formation visible in the image?", "Does the image contain a structure where cell migration or germ layer interactions could be occurring?", "Can you see signs of body patterning, such as axis formation or segmentation?", "Is there a structure maintaining homeostasis through placental exchange or metabolic regulation?", "Does the image show evidence of trophoblast invasion or development of a maternal-fetal interface?", "Can you identify a region where nutrient transport or receptor expression at a placental barrier might be taking place?", "Is there a structure involved in transferring metabolic byproducts like urea or carbon dioxide to another system?", "Does the image include an entity that could be expressing immune-modulatory molecules or receiving maternal antibodies?", "Can you see evidence of hormone synthesis, such as production of human chorionic gonadotropin, or influence on maternal endocrine function?", "Is there a structure involved in regulating amniotic fluid, possibly through urine production or fluid absorption?", "Does the image show features of neurulation, neural tube formation, or early synaptogenesis?", "Can you identify a region where cardiomyocyte differentiation or pacemaker activity might be establishing a heartbeat?", "Is there evidence of skeletal development, such as cartilage templates or ossification processes, in the structure?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see a structure whose anatomical boundaries are defined by bone margins, soft tissues, or nearby neural structures?", "Is there a lesion in proximity to cranial nerves, spinal nerves, or major blood vessels such as the basilar artery?", "Can you identify a mass involving the vertebral bodies or the vertebral column?"], "contexual_behavior": ["Is there evidence of a tumor exhibiting invasive behavior into surrounding tissues, potentially influenced by matrix metalloproteinases?", "Can you identify a tumor that shows reduced extracellular matrix degradation in areas that might correspond to low-nutrient environments?", "Does the image show a neoplasm that may be evading immune surveillance, potentially through the expression of immune checkpoint molecules like PD-L1?"], "functions": ["Does the image show a lesion with evidence of slow growth or local recurrence?", "Can you identify a mass that appears to invade or compress surrounding tissues, leading to structural disruption?", "Can you identify disruption of normal bone remodeling, such as increased osteoclast activity or inhibited bone formation?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify an area that contains fibroblasts, macrophages, or endothelial cells?", "Is there a structure with a thickness that could fall within the range of 50 to 500 micrometers?", "Does the image show a structure with low cellularity, such as about 1,000 to 10,000 cells per cubic millimeter?"], "relational": ["Can you see structures that appear to provide support to organs like the breast, prostate, lung, or colon?", "Is there a visible boundary or interface between basement membrane and adjacent supportive tissue?", "Can you identify fibrous tissue adjacent to epithelial layers or parenchymal regions?"], "contexual_behavior": [], "functions": ["Does the image contain features suggestive of myofibroblast activation or excessive extracellular matrix deposition, as seen in fibrosis?", "Is there a region in the image that provides structural support to the tissue by forming a scaffold of extracellular matrix and connective tissue cells?", "Is there evidence of fibroblast activation, matrix deposition, or support for re-epithelialization in the tissue?"]}}, "rheumatoid arthritis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of joint swelling affecting between 4 and 10 joints?", "Can you identify signs of tenderness in 6 to 12 joints?", "Is there visible morning stiffness that appears to last longer than 60 minutes?", "Does the image display subcutaneous nodules in approximately 20 to 30% of the individuals shown?", "Are there radiographic features indicating mild to moderate joint erosions, with scores that might fall between 10 and 50 on the Sharp/van der Heijde scale?", "Can you observe any extra-articular manifestations present in about 40% of the depicted cases?", "Is there visual evidence suggesting a disease duration spanning 10 to 20 years?", "Does the image suggest the presence of anemia, with hemoglobin levels likely between 10 and 12 g/dL?", "Are there indications of elevated synovial fluid white blood cell counts, possibly ranging from 5,000 to 50,000 cells/\u03bcL?", "Can you infer that the average age of onset for the condition in the individuals shown is between 30 and 60 years?", "Is there evidence suggesting moderate to high disease activity, with a disease activity score (DAS28) likely between 3.2 and 5.1?"], "relational": ["Does the image show evidence of a condition affecting both the musculoskeletal and immune systems?", "Can you identify abnormalities in joints such as those of the hands, wrists, feet, or knees?", "Is there visible damage to structures like the synovial membrane, cartilage, ligaments, or bone within a joint?", "Does the image display chronic inflammation of the tissue lining a joint cavity?", "Are there signs of connective tissue involvement, such as changes in the synovium, tendons, or ligaments?", "Can you see structural alterations in bones such as the phalanges, metacarpals, or carpal bones?", "Is there evidence of joint deformity or bone erosions in the regions commonly affected by autoimmune processes?", "Does the image reveal features like synovial hyperplasia or cartilage erosion within a joint?", "Are there indications of an autoimmune process targeting joint tissues?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Does the image suggest metabolic or liver dysfunction that could influence the degradation rate of a water-regulating hormone?", "Is there a visual cue for physical or emotional stress that could activate the hypothalamic-pituitary axis and increase hormone release?", "Can you identify features suggesting overhydration or low plasma osmolality, which would promote water excretion by the kidneys?"], "properties": [], "relational": ["Can you identify an organ that produces hormones released by the posterior pituitary gland?", "Can you see blood vessels that might contain baroreceptors involved in regulating hormone release?", "Can you identify vascular smooth muscle that might be affected by hormonal activity?"], "contexual_behavior": [], "functions": ["Does the image suggest a response to elevated blood osmolality that would result in greater water reabsorption and osmotic balance?", "Does the image suggest any interaction between mechanisms responsible for fluid and electrolyte regulation, such as those involving aldosterone or angiotensin II?", "Can you identify renal tubules where water reabsorption is facilitated by the insertion of aquaporins in collecting duct cells?"]}}, "saggital section": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears thicker than normal, suggesting the presence of edema or hypertrophy?", "Can you identify any asymmetry in the depicted anatomy that could indicate a unilateral growth or congenital malformation?", "Does the image show areas with abnormal tissue density, which might be consistent with fibrosis or neoplastic changes?", "Is there visible swelling that could be explained by inflammation or fluid accumulation?", "Can you see any region with reduced volume, possibly due to atrophy or tissue degeneration?", "Does the image reveal any distortion of normal anatomical structures, as might occur with masses or traumatic injury?", "Are there areas with abnormal coloration, such as those seen in hemorrhage, necrosis, or pigment deposition?", "Can you identify regions where tissue appears to be missing, which could result from necrosis, infarction, or surgical removal?", "Is there evidence of abnormal mass formation, such as a tumor, cyst, or granuloma?", "Does the image show any localized fluid accumulation that could correspond to a cyst, abscess, or edema?", "Are there visible changes in tissue composition, such as increased fibrous tissue, fatty infiltration, or amyloid deposits?", "Can you see regions with increased opacity, which might be due to calcification, fibrosis, or dense neoplastic tissue?", "Are there abnormal surface features present, such as ulceration, nodularity, or scarring?", "Does the image show signs of hemorrhage, possibly resulting from trauma, vascular rupture, or a bleeding disorder?", "Is there evidence of calcification, which could be associated with chronic inflammation, neoplastic processes, or metabolic disorders?"], "properties": ["Does the image show a thin, flat slice with irregular anatomical contours?", "Can you identify a structure that appears to divide the specimen into left and right portions, consistent with a plane parallel to the median?", "Is there an object whose thickness appears to be in the range of a few micrometers, as seen in histological preparations?", "Does the image contain a slice whose width and length could be measured in millimeters to centimeters?", "Can you see an area that might span from a few square millimeters to several square centimeters?", "Is there a structure whose volume could be estimated by multiplying a micrometer-scale thickness by a millimeter- or centimeter-scale area?", "Does the specimen display pink and purple hues, as would be expected with hematoxylin and eosin staining?", "Is there a region in the image where cellular structures are clearly visible with moderate to strong staining intensity?", "Can you observe a section that is composed of fixed tissue, possibly embedded and stained for microscopic examination?", "Does the object appear to have reduced water content, as would be expected after dehydration steps in tissue processing?", "Is there evidence of a density similar to dehydrated biological tissue, around 1.3 grams per cubic centimeter?", "Can you identify an area where the refractive index might fall between 1.47 and 1.53, depending on the mounting medium?", "Is there a region where the density of cells varies, reflecting differences in tissue type or anatomical region?", "Does the image show a structure with a resolution typical of light microscopy, around 0.2 micrometers?"], "relational": ["Does the image display a view where structures such as the brain, spinal cord, or vertebral column are visible in profile?", "Can you identify anatomical regions like the head, neck, thorax, abdomen, or pelvis as if they are divided from side to side?", "Is there evidence that the section is oriented parallel to the body's midline?", "Does the image show organ systems such as the nervous, respiratory, digestive, or reproductive systems in a side view?", "Can you determine if the body is divided into left and right portions rather than front and back or top and bottom?", "Are tissues like brain tissue, bone, cartilage, or mucosa visible in a way that suggests a side-to-side cut?", "Does the image reveal separation between left and right structures, such as the two cerebral hemispheres or nasal cavities?", "Are anatomical landmarks like the midline, nasal septum, or vertebral bodies visible in a longitudinal orientation?", "Can you see body cavities such as the cranial, vertebral, thoracic, or abdominopelvic cavities in a longitudinal section?", "Is there visual evidence of symmetry or separation of paired organs or limbs, indicating a division into left and right sides?"], "contexual_behavior": ["Does the image show evidence of altered anatomical relationships that could indicate mass effect or displacement?", "Is there any indication that tissue swelling or edema is obscuring normal anatomical landmarks?", "Can you observe changes in the visualization of neural tracts or anatomical structures that might suggest compression or degeneration due to disease progression?", "Is there a failure to accurately display midline structures that could be explained by congenital abnormalities such as agenesis or malformation?", "Does the image provide a clear view of spinal cord deformation or narrowing that would be useful for assessing cord compression?", "Can you identify signs of impaired cerebrospinal fluid flow, such as ventricular enlargement or flow obstruction, that might suggest hydrocephalus?", "Is there evidence of structural disruption or hemorrhage that could indicate trauma and altered organ function?", "Can you see features such as synovial thickening or joint effusion that might affect joint movement in the context of inflammatory arthritis?", "Is there any indication of airway collapse or obstruction that could be relevant for assessing sleep apnea?", "Does the image reveal reduced or absent vascular flow that might suggest vessel occlusion or interrupted blood flow?"], "functions": ["Does the image provide a view that reveals the spatial relationships and alignment of anatomical structures along the body's midline?", "Can you identify how organs and tissues are arranged from front to back in this image?", "Is it possible to observe physiological processes such as swallowing or breathing based on the orientation shown?", "Does the image allow for the visualization of cerebrospinal fluid flow pathways?", "Can you trace the course of neural or vascular structures relative to midline landmarks in this view?", "Is there evidence of dynamic interactions between organs, such as tongue movement during speech or lung expansion?", "Does the image illustrate joint articulation or muscle alignment in a way that informs about biomechanics in the sagittal plane?", "Can you see clear views of midline structures that would be useful for functional visualization in imaging studies?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a figure that seems to have a dynamic range of 10 to 12 bits, allowing for over a thousand levels of gray?", "Is there an image where the brightness for soft tissue appears calibrated to a mid-gray value, around 128 on an 8-bit scale?", "Can you identify a grayscale image that appears to use 256 shades, corresponding to an 8-bit scale?"], "relational": ["Can you observe any evidence of fractures in the image?", "Does the image display anatomical structures such as bones or joints?", "Are tissues such as bone, muscle, fat, or air-filled spaces distinguishable in the image?"], "contexual_behavior": [], "functions": ["Is there visual information that could assist in guiding the placement of medical instruments or devices for a procedure?", "Can you identify differences in tissue density that allow clear depiction of bones or soft tissues in the image?", "Does the image show any masses, lesions, or areas of inflammation that could support the diagnosis of infections or tumors?"]}}, "stenotic foramen magnum": {"yes_questions": {"contexual_properties": ["Does the image show narrowing at the cranial base that could be seen in conditions like achondroplasia or congenital craniosynostosis?", "Is there evidence of decreased diameter at the opening in the skull base suggestive of abnormal bone development as seen in skeletal dysplasias?", "Can you identify increased bone thickening at the cranial base, which may be associated with disorders such as osteopetrosis or metabolic bone disease?", "Does the image reveal irregular margins at the cranial base opening, possibly due to congenital malformations or post-traumatic changes?", "Is there a reduced cross-sectional area at the cranial base in a way that could indicate a genetic disorder affecting cranial base growth?", "Can you see compression at the cranial base opening that might result from excessive bone deposition or premature fusion of cranial sutures?", "Does the shape of the cranial base opening appear altered, possibly due to abnormal ossification or chronic mechanical stress?", "Is there abnormal bone growth at the cranial base, as might be seen in fibrous dysplasia or bone tumors?", "Does the image show increased crowding of neural structures at the cranial base, which could result from congenital or acquired narrowing?", "Can you observe changes in bone density at the cranial base opening, potentially related to metabolic bone disorders or chronic inflammation?", "Is the cranial base opening more oval or misshapen, suggesting a developmental anomaly of the craniovertebral junction?", "Does the image demonstrate increased narrowing at the cranial base in a way that could be seen in syndromic craniosynostosis or skeletal dysplasia?", "Are there bony ridges or spurs present at the cranial base opening, possibly due to chronic mechanical irritation or degenerative changes?", "Can you see signs of reduced cerebrospinal fluid flow at the cranial base, which might occur if the aperture is critically narrowed by bone overgrowth?", "Is there evidence of progressive constriction at the cranial base opening during growth, as might be seen in children with genetic bone disorders affecting the skull base?"], "properties": ["Is there a bony opening at the base of the skull with an anteroposterior diameter less than 19 mm?", "Can you identify a structure whose cross-sectional area appears below 200 mm\u00b2?", "Does the image show an opening with an oval or irregular shape due to narrowing?", "Is there evidence of a minimum anteroposterior diameter between 10 and 15 mm in any cranial opening?", "Can you see a foramen with a transverse diameter reduced to less than 25 mm?", "Is there a bony aperture with a noticeably decreased volume, possibly under 3,000 mm\u00b3?", "Does the surrounding bone of any cranial opening appear unusually thick, measuring over 5 mm?", "Can you observe compact and cancellous bone with abnormal thickening around a major cranial foramen?", "Is there a visible reduction in the size of a cranial opening by 20\u201350% compared to typical dimensions?", "Does the image display a constricted bony opening with thickened margins at the skull base?", "Can you identify bone tissue in the region of a cranial foramen with density values typical of cortical bone (1200\u20131600 Hounsfield units)?", "Is there a cranial opening whose margins appear irregular or sclerotic due to abnormal bone growth?", "Does the image suggest that the narrowing of a cranial opening is present from early development and remains stable after skeletal maturity?"], "relational": ["Is there evidence of an abnormally narrowed opening at the cranial base region of the skull?", "Can you identify a structure whose boundaries are formed by the occipital bone and appears constricted?", "Does the image show a region where the medulla oblongata, vertebral arteries, or spinal accessory nerves would pass through a visibly restricted space?", "Is there a bony opening at the junction of the cranial cavity and vertebral canal that appears reduced in diameter?", "Can you see a constricted area near the lower brainstem or upper cervical spinal cord?", "Is there a narrowed passageway in the skull that could affect the vertebral arteries or anterior spinal artery?", "Does the image display a restricted opening adjacent to the posterior cranial fossa?", "Can you identify a region where the tectorial membrane or alar ligaments would attach to a visibly narrowed bony margin?", "Is there a constricted connection between the cranial cavity and the vertebral canal at the level of the first cervical vertebra?", "Does the image reveal a bony constriction at the cranial base that is smaller than expected for a typical opening in this location?"], "contexual_behavior": [], "functions": ["Does the image show evidence of neural or vascular structures being compressed, potentially leading to neurological deficits?", "Is there any indication of cerebrospinal fluid flow obstruction that could increase the risk of hydrocephalus or syringomyelia?", "Can you identify features suggesting compression of the spinal cord or lower brainstem that might disrupt neural signal transmission?", "Does the image reveal any signs of impaired brainstem function, such as possible autonomic instability or cranial nerve dysfunction?", "Is there visual evidence of compression affecting cranial nerves IX, X, or XI as they exit the skull, which could result in swallowing or speech deficits?", "Can you see any compromise of arterial or venous blood flow that might lead to ischemia or venous congestion in the brain?", "Is there any indication of medullary center involvement that could interfere with respiratory regulation or cause breathing impairment?", "Does the image suggest impaired motor function due to compression of descending motor pathways at the cervicomedullary junction?", "Are there features indicating altered sensory processing, such as compression of ascending sensory tracts that could result in numbness or paresthesia?", "Can you identify any abnormalities that might impact swallowing or speech by affecting the nuclei or fibers of cranial nerves involved in these functions?"]}, "no_questions": {"contexual_properties": ["Is there a noticeable difference in how transparent or opaque certain tissue areas appear?", "Is there a region where the surface texture appears rough, smooth, or irregular compared to surrounding tissue?", "Do you observe any disruptions in tissue integrity, such as fissures, cracks, or breakdown of the surface?"], "properties": [], "relational": ["Can you observe the spatial relationship, such as proximity or orientation, between a detailed area and its surrounding anatomy?", "Does the image show cellular components like epithelial cells, fibroblasts, or endothelial cells at high magnification?", "Can you see anatomical landmarks such as fissures, sulci, glands, or blood vessels in a detailed view?"], "contexual_behavior": ["Is the ability to evaluate global motility or broader anatomical context impaired by the perspective shown?", "Is the evaluation of dynamic physiological processes or temporal changes limited by the spatial context provided in the image?", "Is the detection rate of small tumors potentially increased in this image because of enhanced contrast and magnification?"], "functions": []}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a gently curved bone with an anterior concavity?", "Does the image contain a structure forming an angle of about 120 to 135 degrees with the skull base?", "Is there a structure present that measures approximately 4 to 6 centimeters in length?"], "relational": ["Does the image show a structure that is part of the cranial base?", "Can you identify a location near the hypoglossal canal or jugular foramen?", "Can you see a region that forms the posterior part of the sphenoid bone and the anterior part of the occipital bone, articulating with both?"], "contexual_behavior": ["Is there any indication of compromised separation between the brain and nasopharynx, such as bone loss or abscess formation, that might suggest infection?", "Can you identify any signs of instability or fracture at the base of the skull that might result from trauma?", "Is there evidence of bone swelling or erosion at the cranial base that might be due to inflammatory conditions such as osteitis or granulomatous disease?"], "functions": ["Can you see a structure that connects the sphenoid and occipital bones, reinforcing the central skull base?", "Does the image contain a feature that shields the pons and medulla oblongata from mechanical injury?", "Can you identify a structure that contributes to the structural integrity of the cranial base?"]}}, "fixed tissue": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a specimen in the image that appears pale, whitish, or light tan in color?", "Can you identify a sample that looks firm and rubbery in texture?", "Does the image show a block-shaped or irregularly shaped sample that could have been trimmed from a larger specimen?", "Is there an object whose size appears to be within the range of a few millimeters to several centimeters?", "Can you see a sample that might weigh between 0.1 and 10 grams based on its apparent size and density?", "Is there a structure that could have a reduced water content, around 60\u201370%?", "Does the image contain a specimen that might have a density between 1.05 and 1.10 g/cm\u00b3?", "Can you identify an object that may contain proteins, lipids, nucleic acids, and residual chemicals from processing?", "Is there evidence of a sample that could contain residual fixative agents such as formaldehyde, glutaraldehyde, or ethanol?", "Does the image show a specimen that might have a pH close to neutral, between 6.8 and 7.4?", "Can you see a sample that would likely have a high protein content, making up most of its dry weight?", "Is there a specimen that could have less than 10% lipid content due to processing?", "Does the image include a sample that might have only a small fraction of nucleic acids, possibly fragmented?", "Can you identify a specimen that would be expected to have a high degree of protein cross-linking?", "Is there evidence of a sample that might contain less than 1% formaldehyde by weight after processing?", "Does the image show a specimen with excellent preservation of cellular and structural detail?", "Can you see a sample whose color appears stable but may show signs of gradual fading or yellowing?", "Is there a specimen that could have undergone shrinkage of about 10\u201320% after processing?", "Does the image contain a sample that might have a refractive index between 1.45 and 1.50?", "Can you identify a thin section, possibly 4 to 10 micrometers thick, prepared for microscopic examination?"], "relational": ["Does the image show a chemically preserved sample derived from an organ or tissue?", "Can you identify a specimen that could originate from any organ system, such as the nervous or cardiovascular system?", "Is there a preserved anatomical structure that might represent a biopsy or tumor?", "Does the image contain a sample that could be from the head, thorax, abdomen, or limbs?", "Can you see a structure that may include cell types like epithelial cells, muscle cells, neurons, or immune cells?", "Is there a specimen that appears to be part of a larger anatomical structure, such as an organ or tissue block?", "Does the image show a sample containing substructures like blood vessels, glands, or extracellular matrix?", "Can you identify a specimen that has undergone a preservation process to maintain structural integrity?", "Is there a sample that could represent an organ commonly studied in histology, such as the liver, kidney, lung, or brain?", "Does the image allow you to observe preserved features such as cellular morphology, tissue architecture, nuclei, or cytoplasm?"], "contexual_behavior": ["Is there evidence in the image of tissue that no longer participates in metabolic processes due to chemical treatment?", "Can you identify a sample that appears resistant to enzymatic degradation, possibly due to cross-linking by agents like formaldehyde?", "Does the image show tissue where antigen detection might be compromised, suggesting possible overexposure to fixatives?", "Is there a region where the uptake of staining reagents appears altered, potentially reflecting changes in permeability from different fixative types?", "Can you observe any loss of cellular structure that might indicate incomplete or suboptimal preservation?", "Does the sample show signs of nucleic acid loss, such as diminished nuclear staining, possibly due to prolonged storage or acidic conditions?", "Is there evidence of reduced immunoreactivity in areas that may have been exposed to high temperatures during processing?", "Can you identify tissue that appears less suitable for molecular analysis, perhaps due to excessive cross-linking or fragmentation?", "Does the image suggest differences in protein cross-linking patterns that could result from the use of various fixatives like aldehydes or alcohols?", "Is there a region where enzyme activity appears absent, possibly due to denaturation or disruption of protein active sites by fixatives?"], "functions": ["Does the image show a biological sample that appears stabilized for research or experimental analysis?", "Can you identify a specimen where cellular structures seem well-preserved, suggesting cross-linking of proteins has maintained architectural integrity?", "Is there evidence that enzymatic degradation has been prevented, indicating inactivation of endogenous enzymes in the sample?", "Does the sample in the image appear suitable for long-term storage, with no visible signs of biological decay?", "Can you see a tissue where protein epitopes might be preserved, making it compatible with immunohistochemistry procedures?", "Is there a specimen that appears morphologically stable, allowing for detailed microscopic examination?", "Does the sample seem to have halted biological processes, supporting accurate analytical assessment?", "Can you identify a tissue where the original cellular and extracellular matrix structure is maintained, preventing autolysis?", "Is there a sample that retains diagnostic features necessary for histological evaluation in pathology?", "Does the specimen appear compatible with molecular analysis techniques, such as PCR or sequencing, due to stabilized nucleic acids and proteins?"]}, "no_questions": {"contexual_properties": ["Does the palate structure show changes that are more evident in the late second trimester?", "Is the facial profile visibly altered as the fetus matures, especially after mid-gestation?", "Does the image show a fetus with a noticeably reduced jaw size, particularly if the gestational age corresponds to the second trimester?"], "properties": ["Does the facial profile of the fetus appear receding or convex, possibly due to an underdeveloped mandible?", "Are there visible limb malformations or abnormalities present in the fetus?", "Is there any visual indication that the fetus might have a chromosomal abnormality characterized by three complete sets of chromosomes?"], "relational": ["Does the image show an abnormality in the lower jaw region?", "Is there a visible abnormality in the skeletal system of the head and neck region?", "Does the pharynx or lower facial region appear structurally abnormal?"], "contexual_behavior": ["Is there a fetus in the image with an undersized mandible that could compromise airway patency, especially in late gestation?", "Is there a fetus present with features that could increase the risk of respiratory distress due to mandibular growth failure in the third trimester?", "Can you observe signs of persistent mandibular hypoplasia in a fetus that might affect oral-motor function throughout gestation?"], "functions": ["Does the image show features that could result in poor suckling or feeding inefficiency?", "Is there a structure present that could lead to feeding impairment or difficulty with swallowing?", "Can you identify features that might cause airway obstruction or compromise respiratory function?"]}}, "mesothelioma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show abnormal tissue involving the serous membrane lining the lungs?", "Is there evidence of a lesion affecting the pleura or peritoneum?", "Can you identify changes in the thoracic or abdominal cavity that might indicate disease?", "Is there a visible mass adjacent to the lungs, diaphragm, or chest wall?", "Does the image reveal involvement of the pleural, peritoneal, or pericardial cavity?", "Are there signs of malignant changes in mesothelial or stromal cells?", "Can you see a structure arising from the membrane that lines the lungs?", "Is there evidence of secondary effects on the liver, diaphragm, or heart?", "Does the image suggest invasion into the chest wall, diaphragm, or mediastinum?", "Are there abnormalities in mediastinal, hilar, or diaphragmatic lymph nodes that could indicate disease spread?", "Is there a lesion affecting tissues associated with the respiratory, digestive, or cardiovascular systems?"], "contexual_behavior": [], "functions": ["Does the image show evidence of impaired organ function or systemic effects due to malignant growth in mesothelial tissues?", "Can you identify signs of respiratory distress or restricted lung movement in the image?", "Is there visual evidence of pleural thickening or pleural effusion present?", "Does the image suggest abnormal accumulation of fluid in the pleural cavity, possibly due to impaired absorption?", "Can you see features indicating compression of lung tissue or reduced alveolar surface area?", "Is there evidence of tissue invasion or destruction of pleural or adjacent structures?", "Does the image show a lung that appears encased or has reduced expansion due to surrounding tissue?", "Are there signs of chronic inflammation or altered immune responses in the pleural region?", "Can you identify areas with increased inflammatory cell infiltration or local cytokine release?", "Is there visual evidence of abnormal cellular proliferation or new blood vessel formation in the pleural or thoracic tissues?", "Does the image suggest loss of normal barrier function or uncontrolled growth of mesothelial cells?", "Are there indications of chest wall infiltration or nerve involvement that could be associated with pain generation?", "Can you see signs of lymphatic vessel or node obstruction leading to fluid accumulation in the chest?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show a variant in an intronic region that could affect splicing?", "Does the image show evidence of nucleotide changes such as missense, nonsense, frameshift, or splice site alterations in a gene associated with hereditary cancer risk?", "Can you identify a frameshift mutation, and if so, is it more prevalent than a missense mutation in the sample?"], "relational": ["Can you see any organ that might be relevant to hereditary breast and ovarian cancer syndrome?", "Is there a visible structure that could be part of the reproductive system, endocrine system, or digestive system, which are influenced by certain inherited genetic alterations?", "Can you identify any tissue that might be relevant for assessing familial risk among first-degree relatives like parents, siblings, or offspring?"], "contexual_behavior": [], "functions": ["Does the image reveal abnormal regulation of apoptosis, allowing survival of genetically damaged cells?", "Can you identify regions of abnormal cellular proliferation that might result from defective DNA repair and checkpoint control?", "Is there visual evidence of genomic instability, such as accumulation of DNA damage or chromosomal aberrations?"]}}}
[ { "answer": "remote kidney infarct", "extracted_concepts": [ "large fibrotic scar", "remote kidney infarct" ], "question": "what is replaced by a large fibrotic scar?" }, { "answer": "a large fibrotic scar", "extracted_concepts": [ "large fibrotic scar", "remote kidney infarct" ], "question": "what is the remote kidney infarct replaced by?" }, { "answer": "by a large fibrotic scar", "extracted_concepts": [ "large fibrotic scar", "remote kidney infarct" ], "question": "how is the remote kidney infarct replaced?" }, { "answer": "yes", "extracted_concepts": [ "large fibrotic scar", "remote kidney infarct" ], "question": "is the remote kidney infarct replaced by a large fibrotic scar?" } ]	["large fibrotic scar", "remote kidney infarct"]	{"large fibrotic scar": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show an area within the skin, cardiac muscle, liver, or lung that appears structurally different from the surrounding tissue?", "Can you identify a region in the heart, liver, lungs, kidneys, or skin that seems to have altered texture or color compared to adjacent areas?", "Is there a visible area that might contain an abundance of fibroblasts or myofibroblasts?", "Does the image show a region adjacent to healthy parenchyma, blood vessels, or nerves that appears distinct?", "Can you see an abnormal area located in the chest, abdomen, limbs, or back?", "Is there a region that appears to contain dense connective tissue components such as collagen fibers or elastin?", "Does the image reveal an area where the normal tissue architecture is disrupted or separated, possibly indicating impaired function?", "Can you identify a region that seems to replace part of the organ parenchyma, dermis, or myocardium?", "Is there a visible area associated with blood vessels such as capillaries, arterioles, or venules that appears abnormal?", "Does the image show a region with a dense collagen matrix or other extracellular matrix components like fibronectin or laminin?"], "contexual_behavior": [], "functions": ["Does the image show an area where dense connective tissue has replaced normal tissue, providing structural support but lacking typical function?", "Can you identify a region that appears to impair the restoration of original tissue architecture and function?", "Is there evidence of excessive fibrosis resulting in wound stabilization but limited functional recovery?", "Does the image contain a region where functional parenchyma has been replaced by non-functional fibrous tissue, potentially leading to decreased organ performance?", "Can you see an area characterized by prominent collagen deposition and inhibited normal extracellular matrix turnover?", "Is there a structure that appears to impede tissue elasticity or contractility, suggesting impaired physiological function?", "Does the image show a physical barrier that could prevent the proliferation and migration of regenerative cells, thereby limiting tissue regeneration?", "Can you identify a region that provides mechanical stability at the site of injury through a rigid matrix?", "Is there an area where local blood flow may be reduced due to compression of blood vessels and increased tissue stiffness?", "Does the image reveal a region associated with sustained chronic inflammation or altered immune cell infiltration?"]}, "no_questions": {"contexual_properties": ["Do any spaces appear to have thickened walls, which might suggest chronic inflammation, fibrosis, or scarring?", "Can you observe spaces that are more prominent in regions with increased fluid content or tissue breakdown?", "Can you observe spaces that appear in regions affected by neurodegeneration or ischemic injury?"], "properties": ["Can you identify clear or pale areas with sharply defined edges that appear empty or contain little cellular material?", "Is there any region whose width is less than 1 micrometer or extends up to several millimeters?", "Are there irregularly scattered or infrequently occurring slit-like spaces, possibly following connective tissue planes?"], "relational": ["Is there a narrow gap bordered by connective tissue that might provide structural support?", "Is there a feature present in the integumentary, musculoskeletal, or endocrine system that resembles a slit-like space?", "Does the image show a region within epithelial, connective, or glandular tissue that appears as a narrow space?"], "contexual_behavior": ["Does the image show evidence of increased fluid exchange that could occur during inflammation when endothelial junctions are loosened?", "Does the image suggest reduced permeability, as might be seen during dehydration when endothelial cells contract and junctions tighten?", "Can you identify areas where immune cell migration might be facilitated, as would happen during infection when cytokines widen intercellular gaps?"], "functions": ["Does the image show narrow gaps between adjacent cells that could facilitate the movement of fluids or cells within tissue?", "Can you observe structures that might regulate tissue hydration by permitting water and electrolyte movement between cells and the extracellular matrix?", "Does the tissue display features that would permit nutrient diffusion from capillaries to surrounding cells?"]}}, "remote kidney infarct": {"yes_questions": {"contexual_properties": ["Is there an area within the kidney that appears smaller or shrunken, suggesting tissue atrophy due to chronic ischemia and fibrosis?", "Can you identify a region in the kidney where the normal structure is lost, possibly replaced by fibrous or calcified tissue?", "Does the image show a kidney region with irregular borders, which could indicate chronic scarring and tissue remodeling?", "Is there evidence of increased connective tissue within a portion of the kidney, consistent with fibroblast activity and extracellular matrix deposition during healing?", "Can you see a kidney area that appears denser or more opaque, suggesting replacement of necrotic tissue by fibrous or calcified material?", "Is there a region in the kidney that has changed color, progressing from red to pale or yellow, indicating hemoglobin breakdown and fibrosis?", "Does the image reveal any cystic areas within the kidney that might result from liquefaction necrosis or secondary degeneration?", "Is there a visible area in the kidney with signs of scarring or fibrosis, suggesting chronic tissue repair following necrosis?", "Can you detect a region in the kidney that is more conspicuous on imaging due to increased contrast from fibrotic or calcified changes?", "Is there evidence of tissue shrinkage in a part of the kidney, consistent with replacement of necrotic tissue by contracted fibrous tissue?", "Does the image show a kidney region with signs of dystrophic calcification, indicating late-stage chronic infarct?", "Is there an area within the kidney where normal parenchyma appears to be replaced by fibrous tissue, inflammatory cells, or calcifications?", "Can you identify a region in the kidney that appears to have undergone tissue resorption and fibrosis, resulting in decreased size over time?", "Is there a kidney area that may have increased in size during an earlier phase due to edema and inflammation, but now shows chronic changes?", "Does the image show loss of typical renal architecture in any region, possibly due to necrosis followed by fibrosis?"], "properties": ["Is there a region within the kidney that measures between 1 and 3 centimeters in its greatest dimension?", "Can you identify an area in the kidney that appears wedge-shaped, consistent with a vascular supply pattern?", "Does the image show a pale gray or yellow-white area within the kidney, suggesting tissue loss or fibrosis?", "Is there a firm, fibrotic region visible in the kidney, possibly indicating scar tissue formation?", "Can you see a part of the kidney that appears denser than the surrounding tissue, potentially due to increased collagen?", "Is there a region in the kidney where the water content seems reduced compared to normal renal tissue?", "Does the image reveal a kidney area predominantly composed of fibrous or scar tissue with minimal viable parenchyma?", "Can you identify a kidney region that might contain fibroblasts, occasional inflammatory cells, or rare residual tubular epithelial cells?", "Is there evidence of mild to moderate calcification within a localized area of the kidney?", "Does the image show a region in the kidney with increased protein content, such as collagen accumulation?", "Can you see an area in the kidney that might have significantly reduced oxygen levels due to loss of blood supply?", "Is there a kidney region where the tissue pH could be slightly acidic to neutral, reflecting chronic ischemia?", "Does the temperature of a specific kidney region appear similar to the surrounding tissue, around core body temperature?"], "relational": ["Does the image show evidence of damage in an organ that is part of the renal or urinary system?", "Can you identify an area of tissue loss or abnormality in the cortical or medullary regions of a kidney, away from the hilum?", "Is there a region where the renal parenchyma, including cortical or medullary tissue, appears affected?", "Does the image reveal changes in areas supplied by segmental, interlobar, or arcuate arteries branching from the renal artery?", "Can you see any abnormality adjacent to the renal capsule, perirenal fat, or renal pelvis?", "Is there a visible alteration near the minor or major calyces, or the renal pelvis?", "Does the image show an affected area that could involve nephron components such as glomeruli, proximal tubules, loops of Henle, distal tubules, or collecting ducts?", "Can you identify a region of tissue damage in proximity to the adrenal gland, ureter, spleen, or liver?", "Is there a visible lesion in the kidney that appears distant from the hilum and involves either the cortex or medulla?", "Does the image display any abnormality in the blood supply regions of the kidney, specifically those served by the segmental, interlobar, or arcuate arteries?"], "contexual_behavior": [], "functions": ["Does the image show an area of tissue necrosis within a structure responsible for filtration and urine production?", "Is there evidence of localized dysfunction that could lead to reduced glomerular filtration rate in a specific region?", "Can you identify a region that might be associated with decreased urine output or oliguria due to impaired perfusion?", "Does the image suggest disruption of blood pressure regulation, possibly through altered renin secretion or renal autoregulation?", "Is there a visible area that could be linked to electrolyte disturbances such as hyperkalemia or hyponatremia?", "Can you see a region where the removal of metabolic waste products might be impaired, potentially leading to toxin accumulation?", "Does the image indicate a reduction in hormone production, such as erythropoietin or renin, which could affect systemic physiology?", "Is there evidence of altered fluid homeostasis, such as fluid retention or edema, within the depicted structure?", "Can you identify signs of local or systemic inflammation, such as leukocyte infiltration or cytokine release, in the affected area?", "Does the image suggest a risk of anemia due to decreased erythropoietin secretion and impaired oxygen transport?", "Is there visual evidence of compensatory mechanisms, such as hyperfiltration in remaining functional units or activation of the renin-angiotensin system?", "Can you see features that might indicate impaired acid-base regulation, such as reduced capacity for acid excretion or bicarbonate reabsorption?"]}, "no_questions": {"contexual_properties": ["Can you identify an area where the arrangement of cells or fibers forms a swirling configuration?", "Does the image contain any tissue patterns that resemble a vortex or whirlpool shape?", "Is there a region in the image where elements are organized in a concentric or whorled manner?"], "properties": ["Is there a region where fibers are oriented circumferentially or spirally around a central point?", "Does the image contain a structure that seems firm and rubbery in texture?", "Is there a visible pattern formed by bundles of collagen fibers and spindle-shaped cells?"], "relational": ["Is there evidence of a lesion within the muscularis layer, dermis, or submucosa that exhibits a distinctive structural pattern?", "Does the image show tissue with interlacing bundles or spiral arrangements?", "Does the tissue organization suggest the presence of connective tissue bundles or collagen fibers arranged in a patterned manner?"], "contexual_behavior": ["Can you see spiral or concentric collagen organization that might be associated with wound healing or scar formation?", "Does the image show a loss of organized growth and tissue invasion, as would be expected in malignant transformation?", "Is there a visible pattern that could be altered by hormonal fluctuations affecting stromal and cellular organization?"], "functions": ["Can you identify an area where cell alignment or orientation appears organized in a spiral or circular fashion?", "Can you identify a region where morphogenesis, fibrosis, or neoplastic transformation might be suggested by the tissue pattern?", "Can you see evidence of patterned growth that could reflect either normal development or a pathological process?"]}}}
[ { "answer": "no", "extracted_concepts": [ "large, bulky tumor mass", "borderline serous cystadenoma" ], "question": "is borderline serous cystadenoma opened to show a large, bulky tumor mass?" } ]	["large, bulky tumor mass", "borderline serous cystadenoma"]	{"large, bulky tumor mass": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears to have increased in size, suggesting rapid cellular proliferation?", "Is there an object that seems to have decreased in size, possibly indicating a response to treatment such as chemotherapy or surgical removal?", "Can you identify a region where tissue appears dead or pale, which could be due to insufficient blood supply and necrosis?", "Is there a mass with areas of varying density, possibly reflecting internal changes like fibrosis, necrosis, or calcification?", "Do you see regions within a mass that appear denser or brighter, suggesting the presence of calcification from chronic tissue damage?", "Is there evidence of increased blood vessel formation or enhanced vascularity within a mass, consistent with angiogenesis?", "Can you observe color changes within a mass, such as dark or pale areas, that might be due to hemorrhage, necrosis, or altered pigmentation?", "Does the mass appear softer or firmer in certain regions, possibly due to necrosis, cystic change, or fibrotic tissue formation?", "Are there fluid-filled spaces or cystic regions within a mass, which could result from central necrosis or degeneration?", "Is there evidence of increased metabolic activity, such as heightened glucose uptake, that might be detected on PET imaging?", "Can you see signs of structural breakdown or loss of integrity in a mass, possibly due to extensive necrosis or hemorrhage?", "Are there areas within a mass that appear to contain blood, suggesting intratumoral hemorrhage from fragile vessels?", "Does the mass seem to extend beyond its apparent margins, indicating invasion into surrounding tissues?", "Is there a region with a high density of cells, suggesting increased cellularity and active proliferation?", "Can you identify changes in the internal composition of a mass, such as regions of fibrosis, necrosis, calcification, or cyst formation?", "Is there visible accumulation of fluid within or around a mass, possibly due to cyst formation, edema, or necrosis?", "Do you see evidence of fibrotic tissue, such as firm or scar-like areas, indicating a chronic inflammatory or healing response?", "Is there a surface defect or open area on a mass, suggesting ulceration and invasion of overlying tissue?", "Are there imaging features that indicate changes in size, density, vascularity, or internal structure of a mass over time?", "Can you observe a well-defined border or capsule surrounding a mass, which might indicate fibrous encapsulation as a host response?"], "properties": ["Does the image show a mass that appears to exceed 5 centimeters in its greatest dimension?", "Can you identify a structure that might weigh several hundred grams or more based on its size and bulk?", "Is there an object with an irregular, lobulated, or nodular outline visible?", "Does the image contain a mass with a pale tan or grayish-white color, possibly with areas that appear hemorrhagic?", "Can you see a structure that looks firm or hard, but may have softer regions suggestive of necrosis?", "Is there a mass that could be composed predominantly of abnormal, densely packed cells?", "Does the image show a region where cellular proliferation appears to be high, as indicated by numerous mitotic figures?", "Can you identify an area with significant central necrosis or regions that appear less viable?", "Is there evidence of increased or heterogeneous vascularity within a large mass, such as areas with more or fewer visible blood vessels?", "Does the image reveal a mass with density greater than the surrounding tissue, but with some regions that appear less dense or cystic?", "Can you see areas within a mass that might have elevated water content, such as edematous or necrotic regions?", "Is there a structure that appears to have grown rapidly or is notably larger than typical benign lesions?", "Does the mass appear to have regions where only a portion of the tissue is viable, with the rest showing signs of necrosis?", "Can you identify a mass with moderate to marked fibrous tissue or stromal reaction?", "Is there evidence suggesting an acidic environment within a mass, such as features associated with tissue breakdown?", "Does the image show a region that might be hypoxic, indicated by pallor or lack of vascularization?", "Can you see a mass that may have elevated lipid content, such as one resembling a lipogenic tumor?", "Is there a structure that appears to have high protein content, as suggested by dense cellularity or extracellular matrix?", "Does the mass show signs of slightly elevated temperature, such as increased metabolic activity or hyperemia?", "Can you identify areas within a mass that show focal or extensive calcification?"], "relational": ["Does the image show a mass that could originate from epithelial, connective, muscle, or nervous tissue?", "Is there a structure present that could be located in organs such as the lung, liver, kidney, colon, breast, or ovary?", "Can you identify a mass affecting regions like the abdominal cavity, thoracic cavity, pelvic region, or mediastinum?", "Does the image display a structure that appears to displace adjacent organs, blood vessels, nerves, or muscles?", "Is there evidence of arteries, veins, capillaries, or major vascular structures being involved with a mass?", "Can you see lymph nodes, lymphatic vessels, or lymphatic ducts adjacent to a large structure?", "Does the image contain a mass that might include neoplastic, stromal, immune, or endothelial cells?", "Is there a visible boundary such as a capsule or infiltrative margin surrounding a mass?", "Can you observe a structure that invades neighboring tissues like muscle, fat, blood vessels, nerves, or adjacent organs?", "Does the image show a mass that could impact the digestive, respiratory, urinary, or nervous system?"], "contexual_behavior": ["Is there a structure in the image that could show increased metabolic activity and enhanced glycolysis in areas with limited oxygen supply?", "Can you identify a region where poor vascularization might limit drug delivery and contribute to resistance against chemotherapy?", "Does the image display a mass that appears to compress nearby blood vessels, potentially causing vascular obstruction or ischemia in surrounding tissues?", "Is there evidence of rapid growth in a structure that might stimulate the formation of new blood vessels due to hypoxic zones?", "Can you see an area where immune cell infiltration might be reduced because of a dense extracellular matrix or immunosuppressive barriers?", "Is there a region where tissue stiffness or changes in the extracellular matrix could influence the invasive behavior of a mass?", "Does the image show a structure that might be producing enzymes capable of degrading the extracellular matrix, suggesting potential for invasion or metastasis?", "Can you identify a mass that could resist cell death under nutrient deprivation by activating survival pathways?", "Is there a structure that appears to physically disrupt or displace adjacent tissues, potentially impairing organ function due to compression?", "Can you see evidence of hypoxic signaling, such as features suggesting activation of pathways like HIF-1\u03b1, in response to low oxygen levels?", "Does the image suggest a change in the growth rate of a mass that might be attributed to prior radiation therapy or DNA damage?", "Is there a region where proliferation appears reduced, possibly due to the effects of targeted therapy on oncogenic signaling pathways?", "Can you identify a structure that might evade immune destruction by expressing immune checkpoint molecules or recruiting suppressive immune cells?", "Is there evidence of normalized vasculature or reduced vascular permeability in response to anti-angiogenic treatment?", "Does the image show a region where secretion of immunosuppressive cytokines could be influencing the tumor microenvironment and promoting immune evasion?"], "functions": ["Is there evidence of a structure causing compression or displacement of nearby tissues?", "Can you identify an area where the normal architecture of an organ appears distorted or disrupted?", "Does the image show any obstruction of ducts, hollow organs, or blood vessels resulting in impaired flow?", "Is there a region where blood vessels seem compressed or invaded, possibly leading to reduced perfusion or ischemic changes?", "Can you observe signs of nerve involvement, such as compression or infiltration, that might result in sensory loss?", "Is there visual evidence suggesting pain or discomfort, such as tissue stretching or inflammation near a mass?", "Does the image reveal features of local tissue invasion, such as degradation of the extracellular matrix or new blood vessel formation?", "Can you see indications of impaired lymphatic drainage, such as swelling or fluid accumulation consistent with lymphedema?", "Is there evidence of an inflammatory response, such as immune cell infiltration or tissue injury adjacent to a mass?", "Do you observe areas with altered metabolic activity, such as regions of hypoxia or tissue changes suggestive of increased metabolic demand?", "Is there any sign of an altered immune microenvironment, such as features suggesting immune cell exclusion or suppression near a lesion?", "Can you identify secondary complications like edema or ulceration that might result from disrupted vascular or lymphatic flow?"]}, "no_questions": {"contexual_properties": ["Does the image show cells with altered contractile protein composition, possibly due to phenotypic switching or disease states?", "Are there cells containing vacuoles, which might indicate cellular injury, autophagy, or degenerative processes?", "Can you spot multinucleated cells, which might result from pathological conditions or cell fusion events?"], "properties": ["Can you identify structures that are approximately 100 micrometers in length and 5 micrometers in diameter?", "Can you see cells that are likely to have a water content of about 70\u201380% of their total mass?", "Can you identify cells likely to contain contractile proteins such as actin, myosin, tropomyosin, calmodulin, and desmin?"], "relational": ["Is there a visible layer that could be responsible for regulating the diameter of a vessel?", "Can you see areas where muscle layers are organized to support peristaltic movement?", "Can you identify a structure that might be found in the walls of the uterus, intestines, or blood vessels?"], "contexual_behavior": ["Is there a structure that would increase contraction during stress in response to elevated catecholamine levels?", "Is there a component that could show increased calcium sensitivity in diseases such as pulmonary hypertension or asthma?", "Is there an object that would increase its contraction during cold exposure due to sympathetic activation?"], "functions": ["Is there a structure that produces powerful contractions during labor or menstruation?", "Is there a structure involved in adjusting pupil size in response to changes in light intensity?", "Can you see a tissue coordinating wave-like contractions to move food along the gastrointestinal tract?"]}}, "borderline serous cystadenoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion associated with the female reproductive system?", "Is there an abnormality affecting the organ responsible for oocyte production?", "Can you identify a structure surrounded by ovarian cortex and tunica albuginea tissues?", "Is there a mass adjacent to the fallopian tube, uterine ligament, or pelvic peritoneum?", "Does the image reveal a cystic area lined by epithelial cells with serous or papillary features?", "Can you see a lesion located within the cortical or medullary regions of the ovary?", "Is there a structure in the image supplied by the ovarian artery and ovarian vein?", "Does the mass have boundaries defined by the ovarian capsule or nearby pelvic structures?", "Is there evidence of involvement or compression of the peritoneum, fallopian tube, or other pelvic organs?", "Can you observe a lesion that is separated from but may distort the ovarian stroma?"], "contexual_behavior": [], "functions": ["Does the image show a structure within the ovary that displays papillary projections or cystic spaces?", "Can you identify an area where epithelial cells appear to be proliferating with minimal invasion into the surrounding stroma?", "Is there evidence of ovarian tissue distortion or displacement that could impair normal ovulation?", "Does the image reveal increased mitotic activity or stratification of epithelial cells within a cystic lesion?", "Can you see signs of architectural distortion in the ovary, such as the formation of papillary structures?", "Is there visible accumulation of serous fluid leading to cystic enlargement or ovarian swelling?", "Does the image suggest local inflammation or immune cell infiltration near a cystic ovarian structure?", "Can you identify a lesion that compresses, displaces, or adheres to adjacent ovarian tissue?", "Is there any indication of cellular atypia within the epithelial lining of a cystic ovarian structure?", "Does the image show features consistent with a low risk of malignant transformation, such as minimal stromal invasion?", "Can you observe any signs that suggest possible hormone disruption due to significant ovarian tissue loss?", "Is there evidence of cyst rupture or irritation of surrounding tissue that might induce a local inflammatory response?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a collection measuring between 1 and 4 centimeters in its greatest dimension?", "Can you identify a collection composed of blood, clot, and surrounding edematous muscle tissue?", "Is there an ovoid or lentiform collection within the muscle visible in the image?"], "relational": ["Is there involvement of fascia, such as the temporal fascia or deep temporal fascia, in the observed abnormality?", "Does the image show changes affecting the musculoskeletal system in the area near the temporalis or masseter muscles?", "Can you identify any disruption or abnormality adjacent to the temporal bone or zygomatic bone?"], "contexual_behavior": ["Is there abnormal tissue swelling that could impair muscle function by increasing volume and pressure in the temporal region?", "Does the image suggest chronic muscle dysfunction or unresolved injury following trauma to the temporal area?", "Does the image reveal a hematoma or tissue damage that could increase the risk of secondary infection in the temporal region?"], "functions": ["Does the image suggest limited jaw mobility or trismus, possibly due to underlying tissue changes?", "Does the image reveal tissue changes that could activate nociceptors or cause local irritation?", "Can you identify features that might indicate impaired clearance of cellular debris or prolonged inflammation in a muscle near the temporal bone?"]}}}
[ { "answer": "top of calvaria typical lesions source", "extracted_concepts": [ "typical lesions", "top of calvaria" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "typical lesions", "top of calvaria" ], "question": "does this image show top of calvaria typical lesions source?" }, { "answer": "no", "extracted_concepts": [ "typical lesions", "metastatic carcinoma lung", "top of calvaria" ], "question": "does metastatic carcinoma lung show top of calvaria typical lesions source?" }, { "answer": "multiple myeloma", "extracted_concepts": [ "multiple myeloma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "multiple myeloma" ], "question": "is multiple myeloma present?" }, { "answer": "no", "extracted_concepts": [ "cervical leiomyoma" ], "question": "is cervical leiomyoma present?" }, { "answer": "multiple myeloma", "extracted_concepts": [ "multiple myeloma" ], "question": "what is present?" } ]	["metastatic carcinoma lung", "typical lesions", "multiple myeloma", "cervical leiomyoma", "top of calvaria"]	{"metastatic carcinoma lung": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a pathological process affecting the respiratory system?", "Can you identify abnormal lesions within the lung parenchyma or pleura?", "Is there a visible mass or abnormality in the peripheral lung fields or lower lobes?", "Does the image reveal any involvement of subpleural areas by a suspicious lesion?", "Are there enlarged hilar, mediastinal, or supraclavicular lymph nodes present?", "Can you see any abnormalities in the pulmonary arteries or veins that might suggest vascular dissemination?", "Is there evidence of invasion into adjacent tissues such as the chest wall, pleura, or diaphragm?", "Does the image show any signs of bronchial obstruction or airway compression?", "Are there endobronchial lesions visible within the bronchial tree?", "Can you detect abnormalities in organs such as the liver, bone, brain, or adrenal glands that might indicate secondary involvement?", "Is there visual evidence suggestive of hematogenous or lymphatic spread to the lung?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a process that could lead to impaired respiratory function or reduced oxygenation?", "Is there a structure present that appears to replace normal lung tissue with abnormal masses?", "Can you identify features suggesting airway obstruction or inflammation within the lung?", "Does the image reveal a reduction in alveolar surface area or signs of ventilation-perfusion mismatch?", "Is there visual evidence of decreased oxygen uptake or features that might contribute to anemia?", "Can you see signs of increased airway resistance, decreased lung compliance, or patterns consistent with restrictive or obstructive lung disease?", "Does the image suggest systemic effects such as cachexia or increased metabolic demand, possibly indicated by tissue wasting?", "Are there features that could indicate local immune suppression or immune evasion within the lung microenvironment?", "Is there evidence of abnormal tissue that might facilitate lymphatic or hematogenous spread to other organs?", "Can you identify signs of pleural invasion or pleural effusion, such as fluid accumulation or pleural thickening?", "Does the image show bronchial obstruction or features suggesting impaired mucociliary clearance?", "Is there visual evidence of vascular compression or thrombosis within the lung tissue?", "Can you see indications of reduced lung capacity, hypoxemia, or increased work of breathing?", "Are there features that might suggest increased catabolism, paraneoplastic syndromes, or disruption of energy balance?", "Does the image reveal signs of impaired local defenses or increased risk of infection, such as consolidation suggestive of pneumonia?", "Is there evidence of disruption in respiratory, metabolic, or immune system homeostasis within the lung?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a structure with a firm and rubbery texture?", "Is there a structure with a rich collagen fiber matrix and some reticulin present?", "Does the image reveal a structure with low to moderate vascular density?"], "relational": ["Can you identify a lesion that appears to arise from the outermost layer of the meninges?", "Is there evidence of a lesion primarily involving the dura mater layer of the meninges?", "Does the image show a mass that is external to the brain tissue but may compress or displace it?"], "contexual_behavior": ["Is there a structure whose mitotic activity could be reduced under conditions of decreased progesterone or estrogen levels?", "Can you see a lesion that might increase its invasion into surrounding tissues if matrix metalloproteinases are upregulated or cell adhesion molecules are lost?", "Does the image show a mass that could increase fibrous tissue deposition under chronic stress by stimulating fibroblast activity and extracellular matrix production?"], "functions": ["Is there any visible evidence of compression or encasement of cranial nerves that could result in neuropathy?", "Is there a structure exerting pressure on regions of the brain that could lead to neurological deficits?", "Can you identify a mass that appears to compress or displace nearby brain tissue?"]}}, "typical lesions": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show an area within epithelial, connective, or muscle tissue that appears different from the surrounding tissue?", "Can you identify any abnormal regions affecting the skin, lungs, liver, or kidneys?", "Is there a visible alteration in the dermis, mucosal surfaces, or parenchymal organs?", "Does the image display a region containing inflammatory cells, fibroblasts, or epithelial cells?", "Can you see a structure surrounded by healthy parenchyma, basement membrane, or extracellular matrix?", "Is there evidence of disruption, infiltration, or clear demarcation between an abnormal area and adjacent healthy tissue?", "Does the image suggest involvement of the immune, integumentary, or respiratory system in the formation of an abnormal region?", "Can you identify an area with well-defined borders, uniform cell composition, or predictable growth patterns compared to other abnormal regions?", "Is there a region associated with capillaries, lymphatic vessels, or small ducts?", "Does the image show changes involving the epidermis, dermis, submucosa, or parenchyma?"], "contexual_behavior": ["Is there a structure in the image that appears to heal more slowly, possibly suggesting impaired immune function?", "Can you identify an area with signs of increased inflammation that might be associated with autoimmune diseases such as lupus or rheumatoid arthritis?", "Does the image show a region where normal tissue regeneration seems impaired following infection or chronic tissue damage?", "Is there evidence of delayed wound closure in a context that could be related to diabetes mellitus, such as poor vascularization or abnormal tissue appearance?", "Can you see a lesion that appears more susceptible to secondary infection, potentially indicating compromised immunity?", "Is there a visible area with excessive scar tissue, such as hypertrophic scars or keloids, following trauma?", "Does the image show a lesion that appears to be healing rapidly, possibly due to the influence of growth factors?", "Can you identify a region with impaired healing that might be linked to corticosteroid therapy, such as reduced inflammation or poor fibroblast activity?", "Is there a lesion that has increased in size, possibly as a result of chronic irritation from repeated mechanical, chemical, or physical insults?", "Does the image reveal an area where re-epithelialization appears impaired, potentially due to malnutrition or deficiencies in protein, vitamins, or minerals?", "Can you observe reduced vascularization in a lesion, especially in a context suggestive of advanced age?", "Is there evidence of abnormal collagen deposition in a lesion, which could be associated with fibrotic disorders like scleroderma or pulmonary fibrosis?", "Does the image contain a lesion that appears persistent, possibly indicating an immunocompromised state such as HIV/AIDS or post-transplant immunosuppression?", "Can you identify a lesion with altered healing characteristics that might be related to chemotherapy, such as disrupted tissue architecture or delayed closure?", "Is there a region that demonstrates increased pain sensitivity or hyperalgesia, potentially due to underlying neuropathic conditions?"], "functions": ["Does the image show an area where tissue structure appears disrupted or damaged?", "Is there evidence of cellular damage or altered physiological processes in any region of the image?", "Can you identify a location where normal tissue architecture seems impaired or signaling appears abnormal?", "Is there a region that might be activating local immune responses, such as attracting immune cells?", "Does the image display signs of inflammation, like the presence of inflammatory cells or cytokine activity?", "Is there an area that could be associated with compromised organ function or loss of tissue integrity?", "Can you see features that might suggest chronic inflammation, fibrosis, or the potential for malignant transformation?", "Is there a region where cellular signaling pathways seem disrupted, possibly leading to abnormal cell behavior?", "Does the image show a breach in physiological barriers, such as the epithelial or endothelial layers?", "Is there evidence of increased susceptibility to infection or risk of further injury in any part of the image?", "Can you identify an area where tissue regeneration might be hindered, such as by scar formation or a hostile microenvironment?", "Is there a region with altered blood flow, vascular dysfunction, or new blood vessel formation?", "Does the image show features that could be associated with pain, sensory changes, or nerve injury?", "Can you see evidence of healing processes, such as recruitment of reparative cells or initiation of repair cascades?", "Is there an area where scar tissue appears to be forming or has already formed?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a mass supported by fibrous stroma, blood vessels, or connective tissue visible in the image?", "Can you identify a lesion with a defined capsule, infiltration margin, or interface with adjacent tissue?", "Can you see a mass surrounded by a fibrous capsule or adjacent parenchyma?"], "contexual_behavior": [], "functions": ["Does the image show an abnormal mass of proliferating cells with no apparent beneficial function?", "Is there evidence of altered cell proliferation or impaired cell death in any visible structure?", "Can you identify a region that could be secreting factors to promote neovascularization?"]}}, "multiple myeloma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a disease affecting the hematopoietic system?", "Can you identify abnormalities within bone marrow tissue?", "Is there a visible proliferation of plasma cells?", "Are there lesions present in anatomical sites such as the vertebrae, ribs, pelvis, or skull?", "Does the image reveal disruption of normal bone marrow structure or function?", "Are there signs of involvement in the spine, pelvis, ribs, or long bones?", "Can you observe changes that might indicate altered levels of immunoglobulins, red blood cells, or calcium?", "Is there any indication of interaction between abnormal cells and lymphatic structures like lymph nodes or spleen?", "Do you see evidence of damage to organs such as the kidneys, bones, or components of the immune system?", "Are there features suggesting impaired immune function, such as abnormal antibody production or immune suppression?"], "contexual_behavior": [], "functions": ["Does the image show evidence of widespread dysfunction affecting multiple organs, such as the skeletal, renal, hematopoietic, or immune systems?", "Can you identify any areas of bone destruction, such as lytic lesions or pathological fractures?", "Is there visual evidence of anemia, such as reduced red blood cell presence or signs of decreased erythropoiesis in the bone marrow?", "Does the image suggest suppression of immune function, such as reduced numbers of healthy immune cells or signs of immunodeficiency?", "Can you see abnormal plasma cells that appear to be proliferating uncontrollably within the bone marrow?", "Is there evidence of monoclonal protein accumulation, such as abnormal deposits or changes in blood composition?", "Does the image show signs of bone marrow infiltration, with malignant cells crowding out normal hematopoietic elements?", "Can you identify features consistent with increased osteoclast activity or inhibited osteoblast function, such as areas of osteolysis?", "Is there any indication of kidney dysfunction, such as changes in renal tissue that could be associated with light chain deposition or hypercalcemia?", "Does the image reveal signs of hypercalcemia, possibly related to increased bone resorption?", "Can you see evidence of cytokine-mediated suppression or other factors inhibiting normal bone marrow activity?", "Is there any indication of increased risk of infection, such as reduced levels of functional immunoglobulins or compromised immune cell populations?", "Does the image suggest the presence of paraproteinemia, such as abnormal protein deposits in blood or tissues?", "Can you identify features that indicate complications involving the skeletal, renal, hematopoietic, or immune systems?"]}, "no_questions": {"contexual_properties": ["Does the image show a structure with abnormal color, which might indicate hemorrhage, ischemia, or necrosis?", "Is there evidence of hemorrhage, such as after trauma, torsion, or a ruptured cyst?", "Does the image show a structure that appears atrophic, potentially due to menopause, radiation, or chronic disease?"], "properties": ["Is there a region with mineral content such as calcium, magnesium, or trace elements?", "Can you see an object that contains structural proteins, enzymes, and hormone-binding proteins?", "Does the image show a structure with slightly alkaline pH, around 7.2 to 7.4?"], "relational": ["Does the image show a structure closely related to the fimbriae of the fallopian tube, possibly involved in oocyte capture during ovulation?", "Does the image include an organ that interacts anatomically with the uterus, fallopian tube, or rectum?", "Can you see an object anchored within the pelvic cavity by ligaments such as the ovarian ligament, suspensory ligament, or mesovarium?"], "contexual_behavior": ["Can you see a structure that might increase estrogen synthesis to maintain hormonal balance after the loss of its contralateral counterpart?", "Is there evidence of increased follicular activity in a structure that could compensate for the removal of ovarian tissue on the opposite side?", "Is there a structure that may have altered vascular supply as a result of surgical intervention on the opposite side?"], "functions": ["Does the image contain something responsible for regulating the menstrual cycle through hormone release?", "Does the image show an object interacting with the fallopian tube or ovarian stroma to support reproductive processes?", "Is there a visible feature associated with the release of mature oocytes during ovulation?"]}}, "cervical leiomyoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a mass that is part of the female reproductive system?", "Is there a structure affecting the cervical portion of the uterus?", "Can you identify a lesion surrounded by cervical stroma or smooth muscle tissue?", "Is there a mass located near the vagina, bladder, or rectum?", "Does the image contain a structure that could receive blood supply from branches of the uterine or vaginal arteries?", "Is there a benign tumor arising from smooth muscle visible in the cervical region?", "Can you see a mass connected to the uterine body or endocervical canal?", "Does the image show a lesion composed of smooth muscle cells or fibroblasts?", "Is there a mass supported by ligaments such as the cardinal or uterosacral ligament?", "Can you identify a structure adjacent to reproductive organs like the ovaries or fallopian tubes?"], "contexual_behavior": [], "functions": ["Is there evidence of a mass that distorts the normal anatomy of the uterus?", "Can you identify a structure that might impair uterine contractility?", "Does the image show any feature that could be associated with heavier or prolonged menstrual bleeding?", "Is there a visible abnormality that could explain abnormal uterine bleeding?", "Can you see a mass that might disrupt the endometrial or vascular environment?", "Is there an object that could obstruct the cervical canal or interfere with sperm transport?", "Does the image reveal a structure that might compress the bladder or rectum, potentially causing urinary or bowel symptoms?", "Can you identify a mass that restricts the mobility of the cervix or adjacent pelvic organs?", "Is there a visible narrowing or blockage of the cervical canal?", "Does the image show a finding that could result in cervical stenosis?", "Is there evidence of a mass effect that could cause pelvic pain or a sensation of pressure?", "Can you see a structure that might obstruct the birth canal and increase the risk of delivery complications?", "Is there a feature that could alter local vascular or lymphatic flow, leading to congestion or edema in the pelvic region?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an area where the surface temperature could be around 33 to 35 degrees Celsius?", "Does the skin surface appear consistent with a pH range of 4.5 to 5.5?", "Does the depicted area contain layers or tissues such as skin, fat, muscle, nerves, blood vessels, and bone?"], "relational": ["Can you identify structures formed by bones such as the maxilla or mandible?", "Are there visible blood vessels that could correspond to the facial artery or superficial temporal artery?", "Does the area appear to be covered by layers such as the epidermis or dermis?"], "contexual_behavior": ["Does the image show an area that might lose its ability to regulate temperature in cases of autonomic dysfunction?", "Is there a surface that could show decreased barrier function in dermatological diseases like eczema or psoriasis?", "Can you identify a region where muscular activity changes during speech or mastication due to coordinated muscle contractions?"], "functions": ["Can you identify an area that enables facial expression and mimicry through the movement of soft tissues?", "Is there evidence of coordinated movements for chewing or speech production involving the jaw, lips, or cheeks?", "Can you observe intact skin or mucous membranes that serve as a barrier against pathogens and contribute to immune defense?"]}}, "top of calvaria": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a dome-shaped, convex structure visible in the image?", "Can you identify a bone region that appears pale yellowish-white in color?", "Does the image show a structure whose thickness could be estimated between 4 and 8 millimeters in adults?", "Is there a region that might have a density in the range of 1.7 to 2.0 grams per cubic centimeter?", "Can you see a bone area that could have a surface area of approximately 200 to 250 square centimeters in adults?", "Is there a structure that might weigh between 100 and 150 grams in adults?", "Does the image display a bone with an outer and inner layer of compact tissue and a middle spongy region?", "Can you identify an area that could contain bone cells such as osteocytes, osteoblasts, or osteoclasts?", "Is there a structure that might have a porosity between 5 and 15 percent?", "Can you see a bone region likely to have a water content of about 10 to 20 percent by weight?", "Is there an area that could contain approximately 20 to 25 percent collagen by weight?", "Does the image show a region that might be composed mainly of hydroxyapatite, a crystalline form of calcium phosphate?", "Can you identify a bone area with an estimated calcium content of 35 to 40 percent by weight?", "Is there a structure that could have a phosphorus concentration of about 17 to 18 percent by weight?", "Does the image display a bone region whose hardness might be around 3 to 4 on the Mohs scale?"], "relational": ["Does the image show a region that is part of the cranial vault?", "Can you identify an area formed by the parietal bones and the upper portion of the frontal bone?", "Is there a structure associated with the sagittal or coronal sutures?", "Does the image display layers such as periosteum, connective tissue, or scalp covering a bony surface?", "Can you see a region that overlies the meninges and the cerebral cortex?", "Is there an area where the scalp provides a protective covering over bone?", "Does the image include a region adjacent to the intracranial compartment or the subgaleal space?", "Can you identify a location supplied by branches of the superficial temporal or occipital arteries?", "Is there evidence of nerves such as the greater occipital nerve or supraorbital nerve near a bony surface?", "Does the image show anatomical landmarks like the bregma, sagittal suture, or coronal suture?"], "contexual_behavior": [], "functions": ["Does the image show a structure that acts as a rigid barrier protecting the upper part of the brain from external injury?", "Can you identify a region that provides support for the scalp and overlying soft tissues?", "Is there a bony area that contributes to the dome shape and structural stability of the skull by connecting cranial bones?", "Does the image contain a surface that serves as an attachment site for cranial muscles involved in head movement or facial expression?", "Can you see a structure that helps absorb and distribute forces to reduce the risk of trauma to the cranial cavity?", "Is there a region that contains spongy bone with spaces housing bone marrow involved in blood cell production?", "Does the image include a part that helps maintain the rigid enclosure necessary for regulating intracranial pressure?"]}, "no_questions": {"contexual_properties": ["Is there evidence of fibrotic changes or remodeling in the lung parenchyma, suggesting replacement of normal tissue by fibrous connective tissue?", "Do the lungs appear less compliant or more rigid, potentially due to accumulation of fibrotic tissue and reduced elasticity?", "Are there indications of decreased gas exchange surface area, such as obliteration of alveolar spaces by fibrous tissue?"], "properties": ["Does the pattern of lung involvement suggest a duration of symptoms between 4 and 8 weeks prior to diagnosis?", "Do you see multifocal lesions with a subpleural or peribronchial distribution?", "Do you see signs of increased lung tissue density, possibly in the range of 0.4 to 0.6 grams per cubic centimeter?"], "relational": ["Can you identify changes in the distal airspaces or subpleural regions of the lung?", "Are there visible changes involving terminal or respiratory bronchioles?", "Does the image reveal any abnormalities in alveolar or interstitial tissue?"], "contexual_behavior": [], "functions": ["Does the image show evidence of impaired lung function, such as reduced respiratory efficiency or abnormal lung appearance?", "Are there visible signs of chronic inflammation or immune cell accumulation in the lung parenchyma?", "Can you observe features suggesting decreased lung compliance or restrictive ventilatory patterns?"]}}}
[ { "answer": "close-up view of foramen magnum", "extracted_concepts": [ "foramen magnum" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "foramen magnum" ], "question": "does this image show close-up view of foramen magnum?" }, { "answer": "odontoid process subluxation with narrowing of foramen magnum", "extracted_concepts": [ "narrowing of foramen magnum", "odontoid process subluxation" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "narrowing of foramen magnum", "odontoid process subluxation" ], "question": "is odontoid process subluxation with narrowing of foramen magnum present?" }, { "answer": "odontoid process subluxation with narrowing of foramen magnum", "extracted_concepts": [ "narrowing of foramen magnum", "odontoid process subluxation" ], "question": "what is present?" } ]	["foramen magnum", "narrowing of foramen magnum", "odontoid process subluxation"]	{"foramen magnum": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an opening located centrally at the base of the occipital bone in the image?", "Can you identify an oval or elliptical structure at the skull base?", "Does the image show an aperture with an area between 700 and 900 square millimeters?", "Is there a foramen with a diameter close to 35 millimeters visible in the image?", "Can you see an opening with a circumference of about 100 millimeters?", "Is there a structure oriented obliquely, facing downward and slightly forward at the base of the skull?", "Does the image display an aperture with a height around 30 millimeters?", "Can you identify an opening with a width between 27 and 30 millimeters?", "Is there a visible distance of approximately 10 to 12 millimeters between the central opening and the occipital condyles?", "Does the bone surrounding the central opening appear to have a thickness between 5 and 10 millimeters?", "Is there a smooth, well-defined margin bordered by the occipital bone around the central aperture?", "Can you observe a smooth and regular surface texture on the margin of the opening at the skull base?", "Does the image suggest developmental variation in the size of the central skull base opening, such as differences between infants and adults?"], "relational": ["Can you identify a large opening within the occipital bone?", "Is there a structure located in the posterior cranial fossa of the skull?", "Does the image show an area where the medulla oblongata passes through?", "Can you see a region that allows passage of vertebral arteries?", "Is there an opening through which spinal accessory nerves and meninges traverse?", "Does the image include a feature adjacent to the clivus or jugular tubercles?", "Can you identify a structure near the occipital condyles?", "Is there an area where the lower brainstem or spinal cord could be seen passing?", "Can you see a location where cranial nerve XI might traverse?", "Does the image show attachment points for the tectorial membrane or alar ligaments?", "Is there a visible connection between the cranial cavity and the vertebral canal?", "Can you identify a region that enables continuity between the brain and spinal cord?", "Does the image include vascular structures such as the anterior or posterior spinal arteries near a large cranial opening?"], "contexual_behavior": ["Does the image show evidence of neural compression at the craniovertebral junction, as might occur in congenital malformations?", "Is there any indication of cerebellar tonsillar herniation through an opening at the skull base, suggesting impaired cerebrospinal fluid flow?", "Can you identify signs of brain tissue herniation into the upper spinal canal that could be associated with raised intracranial pressure?", "Is there visible trauma or fracture near the craniovertebral junction that could compromise brainstem protection?", "Does the image reveal a mass or lesion at the skull base that might compress the spinal cord?", "Are there signs of bony overgrowth at the base of the skull that could narrow an aperture and impair vascular flow?", "Can you detect features suggestive of craniovertebral instability, possibly related to connective tissue disorders?", "Is there any abnormality in the size or shape of the opening at the skull base that could indicate a growth disorder or altered skeletal development?", "Does the image show swelling or inflammatory changes near the craniovertebral junction that could obstruct neural passage?", "Are there features of bone weakening or degeneration at the skull base that might reduce structural protection for neural elements?"], "functions": ["Does the image show an opening at the base of the skull that allows passage between the cranial cavity and vertebral canal?", "Can you identify a structure that enables direct anatomical continuity between the brain and spinal cord?", "Is there a visible feature that permits neural tissue to pass from the brainstem into the spinal cord?", "Does the image contain an opening that supports the transition of motor and sensory tracts from the brain to the spinal cord?", "Can you see a structure that allows the vertebral arteries and accessory nerve to pass between the cranial and spinal compartments?", "Is there an anatomical feature that physically links the intracranial and spinal neural compartments, supporting central nervous system connectivity?", "Does the image show a bony boundary at the skull base that helps protect the brainstem and spinal cord during head movement?", "Can you identify an opening that facilitates cerebrospinal fluid flow between the cranial and spinal subarachnoid spaces?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Are there enlarged hilar, mediastinal, or supraclavicular lymph nodes present?", "Does the image show any signs of bronchial obstruction or airway compression?", "Can you see any abnormalities in the pulmonary arteries or veins that might suggest vascular dissemination?"], "contexual_behavior": [], "functions": ["Is there a structure present that appears to replace normal lung tissue with abnormal masses?", "Can you see signs of increased airway resistance, decreased lung compliance, or patterns consistent with restrictive or obstructive lung disease?", "Can you see indications of reduced lung capacity, hypoxemia, or increased work of breathing?"]}}, "narrowing of foramen magnum": {"yes_questions": {"contexual_properties": ["Does the image show evidence of abnormal bone growth or thickening at the craniovertebral junction?", "Can you identify a region where the diameter of a major cranial opening appears reduced compared to normal anatomy?", "Is there visible compression or deformation of neural or vascular structures near the base of the skull?", "Does the image reveal increased bone density or excessive bone deposition in the area where the skull meets the spine?", "Are there signs of altered bone composition suggestive of conditions like osteopetrosis or metabolic bone disease?", "Can you observe imaging findings that indicate a constricted aperture affecting cerebrospinal fluid flow?", "Is there evidence of impingement or deformation of the brainstem or upper spinal cord by adjacent bone structures?", "Does the image suggest rapid progression of bone changes, especially in a pediatric patient or in the context of an aggressive skeletal disorder?", "Are there radiographic or MRI features showing abnormal contours or margins of the cranial base opening?", "Can you see changes in the shape of the cranial opening that might result from bone remodeling or disease progression?", "Is there a visible reduction in the space available for neural or vascular structures at the craniovertebral junction?", "Does the image show features consistent with sclerosing bone dysplasia in the region where the skull and spine connect?", "Are there signs of compromised cerebrospinal fluid circulation due to a narrowed cranial base opening?", "Can you detect any deformation of adjacent anatomical structures resulting from bone overgrowth at the craniovertebral junction?"], "properties": ["Does the image show an opening at the base of the skull with a diameter less than 30 mm?", "Can you identify a structure whose width is below the normal range of 30 to 35 mm?", "Is there evidence of an opening with more than a 20% reduction in area compared to typical size?", "Does the sagittal diameter of the visible cranial opening appear to be less than 30 mm?", "Can you see a foramen with a transverse diameter under 25 mm?", "Is there an opening that appears more oval or constricted than the usual round or oval shape?", "Can you classify the degree of narrowing of the cranial opening as mild, moderate, or severe based on its dimensions?", "Does the cross-sectional area of the opening appear to be less than 500 mm\u00b2?", "Is there increased bone thickness at the margins of the opening, possibly exceeding 5 mm?", "Does the ratio of the opening's dimensions appear to be less than 0.8 compared to standard proportions?"], "relational": ["Is there evidence of a reduced opening at the cranial base where the medulla oblongata and vertebral arteries pass through?", "Can you observe any abnormal narrowing in the large aperture formed by the occipital bone?", "Does the image show any compression or crowding of structures such as the lower brainstem or upper spinal cord near the base of the skull?", "Is there a visible alteration in the continuity between the cranial cavity and the vertebral canal?", "Can you detect any signs of bony overgrowth or thickened tissues at the boundary of the occipital bone?", "Are there indications of congenital malformation affecting the area where the spinal cord exits the skull?", "Does the region adjacent to the cerebellum and clivus appear constricted?", "Is there any visible impact on the dura mater, arachnoid mater, or pia mater at the cranial base opening?", "Can you see any structural changes in the axial skeleton at the junction between the skull and vertebral column?", "Are the accessory nerves or vertebral arteries visibly compressed as they traverse the opening at the base of the skull?"], "contexual_behavior": ["Does the image show evidence of obstruction to cerebrospinal fluid flow between the cranial and spinal compartments?", "Is there any indication of increased risk for brainstem compression during head movement due to restricted space at the craniovertebral junction?", "Can you identify features suggesting reduced neural signal transmission between the brain and spinal cord at the craniovertebral junction?", "Does the image provide clues of impaired respiratory function during sleep, possibly due to compression of brainstem centers controlling breathing?", "Is there any sign of compromised blood flow to the brain during physical exertion, such as compression of vascular structures at the craniovertebral junction?", "Can you see evidence of decreased swallowing efficiency that might result from compression of lower cranial nerves at the craniovertebral junction?", "Does the image suggest exacerbation of symptoms during episodes of increased intracranial pressure, possibly due to a restricted outlet for CSF or blood flow?", "Is there any indication of impaired motor coordination in a pediatric subject, potentially due to compression of developing neural tracts during growth?", "Can you identify features that suggest reduced protective function of the craniovertebral junction during trauma, increasing vulnerability of neural structures?", "Does the image show signs of altered venous drainage from the brain, such as congestion from compression of venous sinuses or veins at the craniovertebral junction?", "Is there any evidence of impaired temperature regulation that could be explained by autonomic dysfunction from compression of descending fibers at the craniovertebral junction?", "Can you see features that would lead to more severe neurological deficits during infection or inflammation, possibly due to further reduction of available space for neural tissue?", "Does the image suggest increased risk of sudden cardiorespiratory compromise, such as compression of vital centers in the medulla during acute events?", "Is there any indication of disrupted growth and development of the nervous system, potentially due to chronic compression at the craniovertebral junction?", "Can you identify signs that the narrowing worsens during periods of rapid skeletal growth, such as disproportionate bone development further restricting the foramen\u2019s diameter?"], "functions": ["Does the image show evidence of compression of neural or vascular structures that could lead to impaired neurological function?", "Is there any indication of cerebrospinal fluid flow obstruction that might increase the risk of hydrocephalus or intracranial hypertension?", "Can you identify features suggesting disruption of neural signal transmission between the brain and spinal cord?", "Is there visible compromise of brainstem structures that could result in deficits in autonomic or motor control?", "Does the image reveal signs of impaired cerebrospinal fluid dynamics or venous outflow that could contribute to raised intracranial pressure?", "Is there any indication of compression affecting the medulla that might cause abnormal breathing or heart rate regulation?", "Can you see evidence of spinal cord compression at the junction with the skull, potentially leading to motor or sensory deficits below that level?", "Are there visual cues suggesting neurological symptoms such as headache, neck pain, ataxia, or weakness due to compromise of neural structures?", "Does the image show possible compression of cranial nerves that could result in dysphagia or vocal cord paralysis?", "Is there any indication of impaired movement or coordination that could be explained by dysfunction of cerebellar or corticospinal pathways?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the sample display a genetic variant present in the heterozygous state?", "Can you identify any genetic variants located in exons 10, 11, 18, or 27 of a tumor suppressor gene?", "Is there a mutation with a high predicted pathogenicity score, such as a truncating or frameshift variant?"], "relational": ["Does the image contain tissue types like breast, ovarian, prostate, or pancreatic tissue, which may be impacted by alterations in homologous recombination repair pathways?", "Does the image show any tissue or organ commonly affected by hereditary cancer syndromes involving genes such as BRCA2 or BRCA1?", "Is there a structure that could be associated with genes interacting in DNA repair, such as RAD51, PALB2, or ATM?"], "contexual_behavior": [], "functions": ["Is there visual evidence of genomic instability, such as accumulation of DNA damage or chromosomal aberrations?", "Can you observe any indications of reduced ability to accurately repair DNA, possibly due to homologous recombination deficiency?", "Is there evidence that the cells or tissue would be more sensitive to DNA-damaging agents, such as platinum compounds or PARP inhibitors?"]}}, "odontoid process subluxation": {"yes_questions": {"contexual_properties": ["Does the image show abnormal alignment at the atlantoaxial joint that could be worsened by trauma or inflammatory arthritis?", "Is there evidence of increased displacement between the first and second cervical vertebrae that might indicate ligament injury or instability?", "Can you identify signs of abnormal joint space width that could suggest synovial inflammation or joint effusion?", "Does the image reveal narrowing of the spinal canal due to posterior displacement of a cervical structure, potentially compressing the spinal cord?", "Are there visible changes in bone structure, such as remodeling or erosion, that might result from chronic instability?", "Is there swelling of tissues around the upper cervical spine that could be due to acute trauma or an inflammatory response?", "Can you see an increased gap between the atlas and a peg-like projection, possibly indicating rupture or laxity of the transverse ligament?", "Does the cervical spine show abnormal curvature that could be a compensatory change from chronic misalignment?", "Are there features suggesting weakened or degenerated ligaments supporting the atlantoaxial joint?", "Is there evidence of bone erosion at the atlantoaxial joint that could be associated with chronic inflammation or rheumatoid arthritis?", "Can you identify signs of increased joint laxity in the upper cervical region, possibly related to connective tissue disorders?", "Are there imaging findings such as sclerosis or pannus formation that would indicate chronic changes at the atlantoaxial joint?", "Does the image appear to be taken during flexion or extension, or does it use advanced imaging modalities like MRI to better reveal instability at the upper cervical spine?"], "properties": ["Does the image show a structure with displacement measuring between 3 and 5 millimeters?", "Is there evidence of angulation at the atlantoaxial joint in the range of 10 to 20 degrees?", "Can you identify anterior or posterior translation between C1 and C2 that is less than 5 millimeters?", "Is the atlantodental interval greater than 3 millimeters in an adult or greater than 5 millimeters in a child?", "Does the image reveal malalignment or a step-off between the anterior arch of the atlas and an adjacent bony process?", "Is there any sign of bone edema that might indicate an acute or traumatic injury on MRI?", "Can you observe cortical irregularity in a region that could be affected by chronic inflammatory conditions such as rheumatoid arthritis?", "Does the MRI show low signal intensity on T1-weighted images and high signal on T2-weighted images in a relevant bony structure, suggesting edema?", "Is there prevertebral soft tissue swelling greater than 6 millimeters at the level of the second cervical vertebra in an adult?", "Can you see abnormal alignment with anterior or posterior displacement of a bony process relative to the anterior arch of the atlas?"], "relational": ["Is there evidence of abnormal alignment at the joint connecting the first and second cervical vertebrae?", "Does the image show any displacement involving the upper cervical spine?", "Can you identify any irregular relationship between the atlas and axis bones?", "Is there a visible disruption of the articulation between the anterior arch of the atlas and the structure projecting from the axis?", "Does the image suggest involvement of ligaments such as the transverse ligament or alar ligaments in the upper cervical region?", "Is there any indication that joint capsules or neural tissue near the upper cervical spinal cord segments might be affected?", "Can you see any abnormal proximity or compression of the spinal cord adjacent to the first and second cervical vertebrae?", "Is there a structure in the axial skeleton of the musculoskeletal system that appears misaligned at the level of C1 and C2?", "Does the image reveal any alteration in the position of tissues near the tectorial membrane or anterior arch of the atlas?"], "contexual_behavior": ["Does the image show evidence of instability in the upper cervical spine, such as abnormal alignment between the first and second cervical vertebrae?", "Can you identify any signs of displacement at the atlantoaxial joint that might compromise ligamentous support?", "Is there visible narrowing of the spinal canal at the C1-C2 level that could increase the risk of spinal cord compression?", "Does the image suggest reduced range of motion or stiffness in the neck due to abnormal joint positioning?", "Are there features consistent with inflammatory changes, such as those seen in rheumatoid arthritis, affecting the atlantoaxial region?", "Can you see any indications of neural structure compression that might lead to impaired neural transmission or nerve root involvement?", "Is there evidence of vascular compromise, such as compression of the vertebral artery, that could affect blood flow to the brainstem?", "Does the alignment of the cervical vertebrae suggest disruption of normal proprioceptive feedback from the neck?", "Are there signs that trauma or sudden movement has resulted in increased mechanical stress or instability at the atlantoaxial joint?", "Can you identify features that might indicate compromised respiratory function due to involvement of neural pathways controlling respiratory muscles?", "Is there any indication of neural compression at the cervicomedullary junction that could impair swallowing or vocalization?", "Does the image show abnormal joint movement or tissue irritation that could be associated with increased pain during neck rotation?", "Are there signs of ligamentous laxity or structural weakness reducing the effectiveness of cervical spine support structures?", "Can you see evidence of dynamic instability or transient compression of neural elements that might occur during physical activity?", "Does the image reveal malalignment of the atlantoaxial joint under mechanical stress, suggesting ligamentous insufficiency?", "Are there indications that immobilization or surgical stabilization has been used to restore normal alignment and prevent further displacement in the cervical spine?"], "functions": ["Does the image show evidence of instability in the cervical spine that could increase the risk of abnormal vertebral motion or spinal cord injury?", "Is there a visible indication of spinal cord compression or stretching that might result in impaired motor or sensory function below a certain level?", "Can you identify any signs of mechanical deformation or ischemia in the cervical spinal cord that could disrupt neural signal transmission?", "Does the image suggest restricted or altered head and neck movement due to instability, pain, or a mechanical blockage?", "Is there any evidence of vertebral artery compression or kinking that could compromise blood flow and increase the risk of ischemic events?", "Can you see features that might contribute to neurological deficits such as weakness, numbness, or paralysis by damaging neural structures in the cervical region?", "Does the image reveal any impairment of respiratory function that could be linked to neural control disruption or direct compression of the medulla?", "Is there any indication of disrupted proprioceptive feedback from the cervical spine, such as abnormal joint alignment or altered sensory input?", "Can you identify signs of impaired protective reflexes in the neck, such as issues with the head righting reflex, due to instability or altered neural signaling?", "Does the image show abnormal alignment or biomechanics of the cervical vertebrae that could lead to uneven load distribution or increase the risk of degenerative changes?"]}, "no_questions": {"contexual_properties": ["Are there several distinct areas that appear larger than typical anatomical features in the image?", "Does the image contain multiple regions that differ in size or shape from the surrounding tissue?", "Does the image show multiple abnormal areas that are noticeably larger than surrounding structures?"], "properties": ["Does the image show multiple abnormal areas that appear larger than typical surrounding structures?", "Are there several distinct areas that are noticeably larger than other features in the image?", "Does the image contain multiple sizable regions that might indicate pathological changes?"], "relational": ["Can you detect areas that might contain inflammatory, necrotic, or tumor cells?", "Does the image show abnormal areas affecting epithelial, connective, or muscle tissue?", "Is there visual evidence of tissue compression, invasion, or local inflammation near abnormal regions?"], "contexual_behavior": ["Can you see areas where increased diffusion distances or necrotic zones with poor perfusion might reduce the effectiveness of local drug delivery?", "Does the image suggest accumulation of cellular debris, possibly due to overwhelmed local phagocytic capacity?", "Are there wounds of increased size or complexity that could complicate closure and delay recovery after surgical intervention?"], "functions": ["Are there regions that could be triggering an inflammatory response, possibly through the release of damage-associated molecular patterns?", "Can you see areas that might be attracting immune cells or promoting cytokine release?", "Does the image show areas where tissue or organ function appears compromised due to structural disruption?"]}}}
[ { "answer": "complete hydatidiform mole", "extracted_concepts": [ "numerous swollen villi", "complete hydatidiform mole" ], "question": "what consists of numerous swollen villi?" }, { "answer": "numerous swollen villi", "extracted_concepts": [ "numerous swollen villi", "complete hydatidiform mole" ], "question": "what does the complete hydatidiform mole consist of?" }, { "answer": "yes", "extracted_concepts": [ "numerous swollen villi", "complete hydatidiform mole" ], "question": "does the complete hydatidiform mole consist of numerous swollen villi?" }, { "answer": "no", "extracted_concepts": [ "villi", "cellular adaptation", "swollen villi" ], "question": "does the cellular adaptation depicted here consist of numerous swollen villi?" } ]	["villi", "cellular adaptation", "swollen villi", "numerous swollen villi", "complete hydatidiform mole"]	{"villi": {"yes_questions": {"contexual_properties": ["Does the image show structures that appear shortened, as might be seen in chronic inflammation or celiac disease?", "Can you identify any features that look flattened, which could indicate severe mucosal injury or advanced enteropathy?", "Are there elongated projections that might suggest an adaptive response to increased nutrient demand or recent intestinal resection?", "Is there a noticeable decrease in the number of finger-like projections, possibly reflecting mucosal atrophy or extensive epithelial loss?", "Do any of the structures appear blunted, which could be associated with autoimmune enteropathies or chronic inflammation?", "Can you see any projections that look swollen, as might occur with acute inflammation or mucosal edema?", "Are there areas where the normal architecture of the projections is lost, potentially due to severe infection, autoimmune disorder, or toxic injury?", "Do any of the projections appear fused together, which could result from congenital disorders or severe mucosal damage?", "Is there a change in color of the projections, possibly indicating ischemia, hemorrhage, or pigment deposition?", "Are there signs of atrophy in the projections, as might be seen in chronic malabsorption syndromes or prolonged nutrient deficiency?", "Do any of the structures show increased cellularity, which could be a response to active inflammation or lymphocytic infiltration?", "Are there thickened projections that might suggest chronic irritation or compensatory growth after injury?", "Can you observe accumulation of inflammatory cells within the projections, as might occur during infection, autoimmune disease, or allergic reaction?", "Do any of the structures appear edematous, possibly due to increased vascular permeability or local inflammation?", "Is there evidence of abnormal surface texture on the projections, which could result from epithelial damage or excessive mucus production?", "Are there projections that appear thickened, potentially reflecting chronic inflammatory conditions or hyperplastic states?", "Do any of the structures lack a brush border, as might be seen in enteropathies that damage enterocytes or disrupt microvilli?", "Is there evidence of increased permeability in the projections, which could be associated with inflammation, infection, or barrier dysfunction?", "Can you identify ulcerations on the projections, as might occur in severe inflammatory bowel disease or infectious enteritis?", "Are there visible changes in the epithelial composition of the projections, possibly due to chronic injury, metaplasia, or regenerative processes?"], "properties": ["Does the image show finger-like or leaf-shaped projections within the tissue?", "Can you identify structures that are approximately 0.5 to 1.5 millimeters in length?", "Are there projections with an average width close to 0.1 millimeters?", "Is there evidence of a high density of projections, about 10 to 40 per square millimeter?", "Can you see structures that contribute to a large surface area, possibly around 30 square meters in total?", "Are there visible features that appear pale pink due to vascularity?", "Do the projections contain a central capillary network or a lacteal?", "Is there an epithelial layer covering the projections that appears to be about 20 to 40 micrometers thick?", "Can you identify cells such as enterocytes, goblet cells, enteroendocrine cells, or Paneth cells within the projections?", "Are there signs of connective tissue, such as collagen or fibroblasts, in the core of these structures?", "Do the projections have a height-to-width ratio close to 10:1?", "Is there a visible glycocalyx layer on the surface, possibly 0.1 to 0.5 micrometers thick?", "Can you infer that the water content of these structures is high, around 70% by weight?", "Are the projections likely to have a low lipid content, approximately 2\u20135% by weight?", "Is there evidence of structural proteins, enzymes, or transporters present in these projections?", "Can you see indications of glycoproteins or glycocalyx components on the surface of the projections?", "Do the cells covering each projection appear to have thousands of microvilli?", "Is the local pH at the surface of these projections likely to be between 6.5 and 7.5?", "Can you estimate that the average volume of a single projection is about 0.01 cubic millimeters?", "Is there evidence of brush border enzymes present at micromolar concentrations on the surface of these structures?"], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify projections that are found within the small intestine?", "Is there evidence of specialized extensions of the intestinal mucosa?", "Does the image contain features supported by the lamina propria?", "Are there visible regions corresponding to the duodenum, jejunum, or ileum?", "Can you see structures composed of epithelium and connective tissue?", "Is there a presence of capillary networks or small blood vessels within any projections?", "Does the image show lymphatic structures such as lacteals within mucosal extensions?", "Are there cells present that resemble enterocytes, goblet cells, or Paneth cells?", "Can you identify projections containing both blood vessels and lymphatic channels?"], "contexual_behavior": ["Is there a structure in the image that shows signs of reduced nutrient absorption, possibly due to mucosal damage from intestinal inflammation?", "Can you identify an area where absorptive function appears diminished, as might be seen in celiac disease after gluten exposure?", "Does the image display elongated or hyperplastic features that could indicate increased surface area for absorption following fasting?", "Is there evidence of impaired fat absorption, such as structural abnormalities or dysfunctional enterocytes, which might be seen in malabsorption syndromes?", "Can you observe regions that appear to be regenerating rapidly, possibly due to recent injury and the influence of growth factors?", "Is there a structure that shows signs of impaired function or epithelial damage, which could result from chronic infection and persistent inflammation?", "Does the image reveal reduced enzyme activity or loss of specialized cells, as might occur in lactose intolerance with diminished lactase-producing enterocytes?", "Can you see areas where the surface appears flattened, suggesting decreased function and absorption, as might happen after gluten exposure in susceptible individuals?", "Is there evidence of increased water absorption, such as enhanced transport mechanisms, which could be present during dehydration?", "Does the image show features consistent with reduced nutrient uptake, possibly due to cytotoxic effects on rapidly dividing epithelial cells during chemotherapy?", "Can you identify regions with increased cell proliferation and surface area, indicating enhanced absorption after a period of nutrient deficiency?", "Is there evidence of reduced function or mucosal injury, as might be observed in inflammatory bowel disease due to chronic inflammation?", "Does the structure appear to have altered absorption capacity, possibly reflecting adaptation to a high-fat diet through changes in enterocyte gene expression?", "Can you observe signs of impaired micronutrient transport, such as defects in transporter proteins or cellular metabolism, which might be seen in certain genetic disorders?", "Is there evidence of increased activity or structural adaptation to meet elevated nutritional demands during periods of rapid growth?"], "functions": ["Does the image show finger-like projections that increase the surface area of the intestinal lining?", "Can you identify structures that facilitate the absorption of nutrients from the intestinal lumen?", "Is there evidence of specialized epithelial cells involved in nutrient uptake?", "Does the image display features that enable the transfer of digested molecules into the body?", "Are there visible projections that provide greater contact with chyme in the intestine?", "Can you see structures containing capillaries and lacteals for transporting nutrients into the bloodstream?", "Is there evidence of an extensive absorptive surface for vitamins and minerals?", "Does the image show features that could assist in fat absorption through the uptake of chylomicrons?", "Can you identify structures that enable efficient transfer of water and electrolytes across the intestinal epithelium?", "Is there visual evidence of tight junctions or mucus secretion contributing to intestinal barrier function?", "Does the image show the presence of immune cells, such as lymphocytes, or features related to antimicrobial defense within the intestinal lining?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a bone present with a water content of approximately 10 to 20 percent by weight?", "Can you see a bone containing cells such as osteocytes, osteoblasts, and osteoclasts?", "Can you see a structure with transverse processes measuring around 2 cm in length?"], "relational": ["Does the image contain a joint that enables head rotation, such as a pivot joint between two cervical vertebrae?", "Is there evidence of the atlanto-occipital or atlanto-axial joint present in the image?", "Is there a bone in the cervical region of the spine visible in the image?"], "contexual_behavior": ["Can you observe weakened support for the occipital condyles, such as might occur in rheumatoid arthritis with ligamentous erosion?", "Is there evidence that vertebral artery flow could be compromised by subluxation, fracture, or vascular compression in the cervical region?", "Is there visible limitation of movement in the upper cervical region due to muscular spasm, such as in torticollis or cervical muscle strain?"], "functions": ["Can you identify an anatomical feature that helps maintain posture by supporting the alignment of the head on the cervical spine?", "Is there a structure that assists in stabilizing the head through strong ligamentous and bony connections with the skull and another vertebra?", "Is there a bony ring encircling and protecting the upper portion of the spinal cord as it transitions from the brain to the vertebral column?"]}}, "cellular adaptation": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show tissue with regions where cell size or shape appears altered compared to normal?", "Can you identify areas where cells seem enlarged or shrunken, suggesting changes like hypertrophy or atrophy?", "Is there evidence of increased cell numbers in any region, which could indicate hyperplasia?", "Do you observe any areas with decreased cell density, as might be seen in atrophy?", "Are there visible changes in tissue architecture that could reflect metaplasia or other forms of adaptation?", "Can you see cells with enlarged cytoplasm or modified organelle content?", "Is there evidence of altered plasma membrane features in any cells?", "Do any regions show signs of mitochondrial proliferation or increased lysosomes?", "Are there cells with dilated endoplasmic reticulum visible in the image?", "Can you detect nuclear changes such as chromatin condensation, nuclear enlargement, or prominent nucleoli?", "Is there evidence of increased protein content, lipid, or glycogen accumulation within the cytoplasm?", "Do any areas display staining patterns like increased eosinophilia, variable basophilia, or inclusion bodies?", "Are there features suggesting enhanced glycolysis or increased protein synthesis, such as expanded cytoplasm or organelles?", "Can you identify regions where the Golgi apparatus or endoplasmic reticulum appears more prominent?", "Is there any indication of upregulated stress response, such as increased stress protein expression or altered metabolite concentrations?", "Do you observe any features that could reflect changes occurring over hours to weeks, such as progressive tissue remodeling?"], "relational": ["Does the image show any tissue that could be epithelial, muscle, or connective in nature?", "Can you identify an organ such as the heart, liver, kidney, or lungs that might exhibit changes consistent with adaptation?", "Is there evidence of cell types like epithelial cells, myocytes, fibroblasts, or hepatocytes undergoing structural changes?", "Does the image include structures belonging to the cardiovascular, respiratory, or renal systems that might be affected by adaptive processes?", "Can you see anatomical features such as blood vessels, alveoli, or renal tubules that could display signs of adaptation?", "Is there visual evidence of tissue remodeling processes like hypertrophy, hyperplasia, or atrophy?", "Does the image contain regions such as the myocardium, bronchi, or liver parenchyma that might show adaptive changes?", "Can you observe alterations in cell size, increased numbers of organelles, or changes in the cytoskeleton within any visible cells?", "Is there interaction between cells and extracellular structures like the extracellular matrix, basement membrane, or collagen fibers?", "Are there features in the image that suggest adaptation occurring at the molecular, cellular, tissue, or organ level?"], "contexual_behavior": [], "functions": ["Does the image show evidence of cells adjusting their structure or function in response to environmental stress?", "Can you identify features suggesting that cells are modifying their physiology or morphology to withstand stress?", "Is there visual evidence of tissue maintaining integrity by balancing cell survival, proliferation, and death?", "Does the image display signs of protective responses such as hypertrophy, atrophy, or autophagy to minimize cellular injury?", "Can you see indications of tissue repair, such as increased cell proliferation or differentiation after injury?", "Is there evidence that cells are surviving in adverse conditions, potentially contributing to chronic disease or malignancy?", "Does the image suggest that cells are altering gene expression, metabolism, or structural components to adapt to environmental changes?", "Can you observe features consistent with metabolic reprogramming or shifts in energy balance within the tissue?", "Is there visual evidence of immune cells adjusting their response to pathogens or inflammatory signals?", "Does the image show signs of regulated cell growth or division in response to internal or external cues?", "Can you identify features associated with cellular aging, such as senescence or altered repair capacity?", "Is there evidence that cells are activating detoxification pathways or altering membrane transport to resist toxins?", "Does the image display signs of recovery or restoration of normal cellular function after damage?"]}, "no_questions": {"contexual_properties": ["Can you identify a structure with a change in shape, which might be caused by growth, trauma, or underlying pathology?", "Is there evidence of discharge from a structure, which could be related to infection, hormonal stimulation, or cystic changes?", "Is there a structure that seems to contain additional glandular tissue, possibly due to embryological development or hormonal stimulation?"], "properties": ["Is there evidence of a structure with tissue density ranging from soft to firm, resembling that of normal nipple tissue?", "Can you see a structure that may have hair follicles, with a frequency similar to the adjacent skin?", "Does the image contain one or more small, nipple-like projections along the chest or abdomen, possibly following the embryonic milk line?"], "relational": ["Can you identify more than one structure resembling a nipple or areola on the chest or abdomen?", "Does the image show an abnormality affecting the integumentary system?", "Can you observe duplicated structures that might be explained by persistence of the mammary ridge?"], "contexual_behavior": ["Is there evidence of disrupted milk duct drainage, possibly caused by malformed or obstructed accessory ducts?", "Can you identify any features that could affect the sensory function of the breast, such as abnormal innervation?", "Is there evidence of structures that might alter the breast\u2019s response to hormonal changes during puberty?"], "functions": ["Is there a benign anatomical variation present that appears to have minimal impact on function?", "Can you see a structure that may respond to hormonal changes during puberty or pregnancy, but less so than the primary feature?", "Can you identify an accessory structure that is unlikely to interfere with lactation due to a lack of developed glandular tissue?"]}}, "swollen villi": {"yes_questions": {"contexual_properties": ["Does the image show finger-like projections that appear enlarged, possibly due to acute inflammation, infection, or edema?", "Can you identify structures that are elongated, which might indicate chronic irritation or mucosal adaptation?", "Is there evidence of color changes in mucosal projections, suggesting ischemia, hemorrhage, or inflammation?", "Do any villous structures appear more edematous, potentially due to increased capillary permeability or lymphatic obstruction?", "Can you see projections with increased fluid content, as might be seen in tissue edema or with inflammatory exudate?", "Are there surface texture abnormalities on mucosal projections, which could be due to epithelial injury, infection, or villous atrophy?", "Do any of the villous structures appear blunted, possibly as a result of celiac disease or persistent inflammation?", "Is there loss of normal architecture in mucosal projections, which might indicate severe inflammation, infection, or autoimmune damage?", "Can you observe increased cellular infiltration within villous structures, suggesting active inflammation or an immune response?", "Do any projections appear more fragile, which could be associated with mucosal injury, infection, or nutritional deficiency?", "Are there villous structures with thickened walls, potentially due to chronic inflammation, fibrosis, or persistent edema?", "Can you see accumulation of inflammatory cells within mucosal projections, as might occur in infection, allergic reactions, or autoimmune disorders?", "Do any of the projections appear pale, which could be a sign of anemia, ischemia, or reduced perfusion?", "Is there increased vascularity visible in the mucosal projections, possibly indicating active inflammation or angiogenesis?", "Do any villous structures appear shortened or decreased in height, as might be seen in chronic enteropathies, villous atrophy, or prolonged inflammation?", "Are there visible mucosal changes in the projections that could be associated with inflammatory bowel disease, infection, or allergy?", "Can you identify areas where mucosal projections are fused together, which might suggest severe mucosal injury, chronic inflammation, or congenital malformation?", "Is there evidence of increased permeability in the mucosal projections, possibly due to acute inflammation, infection, or barrier dysfunction?", "Do any projections show abnormal composition, such as infiltration by inflammatory cells, fibrosis, or lipid accumulation?", "Is there a change in the density of mucosal projections, which could result from edema, fibrosis, or cellular infiltration?"], "properties": ["Does the image show finger-like structures that appear blunted or broadened compared to normal?", "Can you identify any features that are pale or whitish in color, rather than healthy pink?", "Are there structures present that measure between 0.5 and 2 millimeters in length?", "Is there evidence of finger-like projections with a width ranging from 0.2 to 0.5 millimeters, possibly wider than usual?", "Do you observe any projections whose length appears reduced to between 0.5 and 1.5 millimeters?", "Are there structures with a decreased surface area, possibly measuring only 1 to 2 square millimeters each?", "Can you see finger-like projections composed of enterocytes, goblet cells, immune cells, and connective tissue?", "Do any of the structures appear soft or spongy in texture, suggesting increased water content?", "Is there visual evidence of decreased density in any finger-like projections, possibly due to fluid accumulation?", "Are there features that might have a water content exceeding 80% by weight, as indicated by their appearance?", "Can you identify projections that might have a slightly decreased protein content per unit volume?", "Are there finger-like structures where the lipid content appears normal, primarily within cell membranes?", "Do you observe projections whose carbohydrate content is mainly in the form of glycoproteins and mucins?", "Is there evidence of finger-like structures containing between 2,000 and 5,000 epithelial cells each?", "Can you see signs of moderate to severe interstitial fluid accumulation within finger-like projections?", "Are there features with increased vascularization, such as dilated capillaries or enhanced blood flow?", "Do any projections have an epithelial layer thickness of approximately 20 to 30 micrometers, possibly slightly increased?", "Is there visual evidence of elevated concentrations of immune cells, particularly lymphocytes and plasma cells, within finger-like structures?", "Can you identify projections that might show increased presence of inflammatory markers such as cytokines or adhesion molecules?"], "relational": ["Does the image show a structure that is part of the digestive system and located in the lining of the small intestine?", "Can you identify features adjacent to the intestinal crypts and the lumen of the intestine?", "Is there a region surrounded by the lamina propria and the epithelial layer of the intestinal mucosa?", "Can you see structures containing enterocytes, goblet cells, or lymphocytes?", "Does the image display features with increased width, edema, or blunted or fused tips compared to normal intestinal projections?", "Is there evidence of specialized structures within the intestinal mucosa that contribute to the absorptive surface?", "Can you identify these features in any region of the small intestine, such as the duodenum, jejunum, or ileum?", "Is there a visible blood supply from capillaries that could be derived from branches of the superior mesenteric artery?", "Does the image show lymphatic structures such as central lacteals or submucosal lymphatic vessels associated with intestinal projections?"], "contexual_behavior": ["Is there evidence of a structure in the intestine where nutrient absorption appears impaired due to inflammation or epithelial injury?", "Can you identify features suggesting fluid imbalance or edema interfering with normal transport processes in the intestinal lining?", "Does the image show reduced surface area for digestion, possibly due to blunting or fusion of finger-like projections in chronic disease?", "Is there a region where enzyme secretion might be compromised because of pathological swelling affecting enterocyte function?", "Can you observe signs of decreased barrier function against pathogens, such as loss of tight junction integrity during inflammation?", "Is there visual evidence of impaired glucose uptake, potentially resulting from mucosal injury or reduced transporter expression?", "Does the image display changes consistent with immune-mediated damage, such as atrophy and swelling of intestinal projections seen in celiac disease?", "Are there indications of malabsorption and mucosal disruption associated with chronic inflammation, as seen in inflammatory bowel disease?", "Can you detect signs of impaired fat absorption after infection, possibly due to enterocyte damage affecting chylomicron formation?", "Is there a region where regeneration appears inefficient, perhaps due to inhibited stem cell proliferation in the presence of ongoing inflammation?", "Does the image suggest increased permeability to toxins, possibly resulting from disruption of intercellular junctions by swelling?", "Can you see evidence of reduced immune surveillance, such as impaired lymphocyte trafficking in areas affected by villous edema?", "Are there features indicating worsened nutrient transport during chronic inflammation, potentially linked to altered transporter function by persistent cytokine activity?", "Does the image suggest recovery of absorptive function following removal of a dietary trigger and subsequent mucosal healing?", "Is there visual evidence of impaired electrolyte absorption during an episode of acute gastroenteritis, possibly due to epithelial disruption by infection?"], "functions": ["Does the image show intestinal structures with reduced surface area that could compromise absorption?", "Is there evidence of villus disruption that might lead to malabsorption or nutrient deficiency?", "Can you identify features that suggest impaired digestive processes due to limited enzyme access or substrate interaction?", "Does the image reveal signs of barrier dysfunction, such as increased permeability or potential entry points for pathogens?", "Are there visual cues indicating altered mucosal immunity or disrupted antigen presentation within the gut lining?", "Can you see features that might be associated with fluid or electrolyte imbalance, potentially leading to diarrhea?", "Is there evidence of impaired transport of macromolecules across the intestinal wall due to epithelial disruption?", "Does the image suggest delayed regeneration or disruption of the stem cell niche in the intestinal lining?", "Are there signs of villus atrophy or reduced absorptive capacity that could contribute to malabsorption syndromes?", "Can you observe decreased enzymatic activity on the intestinal surface, such as reduced brush border enzyme presence?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a visible area that might contain an abundance of fibroblasts or myofibroblasts?", "Is there a visible area associated with blood vessels such as capillaries, arterioles, or venules that appears abnormal?", "Can you identify a region in the heart, liver, lungs, kidneys, or skin that seems to have altered texture or color compared to adjacent areas?"], "contexual_behavior": [], "functions": ["Does the image show a physical barrier that could prevent the proliferation and migration of regenerative cells, thereby limiting tissue regeneration?", "Does the image contain a region where functional parenchyma has been replaced by non-functional fibrous tissue, potentially leading to decreased organ performance?", "Can you identify a region that appears to impair the restoration of original tissue architecture and function?"]}}, "numerous swollen villi": {"yes_questions": {"contexual_properties": ["Does the image show finger-like projections that appear enlarged or swollen?", "Can you identify multiple structures with a villous shape that seem abnormally distended?", "Is there evidence of numerous elongated surface features that are thicker than usual?", "Does the image display a region where many villi appear to be swollen or edematous?"], "properties": ["Does the image show structures that are larger than typical villi, measuring between 0.5 and 2 mm in diameter?", "Can you identify more than 20 villous structures within a single low-power microscopic field?", "Are there any features with a club-shaped or bulbous appearance present?", "Is there a region displaying a pale or whitish coloration suggestive of fluid accumulation?", "Do the elongated structures appear slightly shorter than healthy villi, with lengths between 0.5 and 1.5 mm?", "Are there villous structures with an increased width, commonly between 0.2 and 0.5 mm?", "Can you observe moderate to marked swelling or visible distention in any villous structures?", "Is there evidence of a soft, spongy, or edematous texture in the tissue?", "Do any areas appear to have high water content, possibly due to interstitial edema?", "Are cell types such as enterocytes, goblet cells, lymphocytes, or inflammatory cells visible within the villous structures?", "Can you detect increased capillary density or dilated capillaries within the villi?", "Is there a mild increase in epithelial thickness observable in the villous structures?", "Does the tissue surface area appear expanded due to an increased number and swelling of villi?", "Are there signs of slightly reduced protein content, such as protein loss into the interstitial space?", "Is the lipid content of the villous structures consistent with normal levels, unless there is evidence of malabsorption?"], "relational": ["Does the image show projections within the digestive system that are lined by epithelial or connective tissue?", "Can you identify structures adjacent to intestinal crypts or the lamina propria?", "Is there evidence of projections located in regions such as the duodenum, jejunum, or ileum?", "Does the image contain features populated by cells like enterocytes, goblet cells, or Paneth cells?", "Are there visible capillary loops, arterioles, or venules supplying any of the projections?", "Can you see lymphatic structures such as lacteals or lymphatic capillaries associated with any projections?", "Are there structures related to the mucosa or submucosa layers of the intestinal wall?", "Do you observe specialized projections arising from the intestinal mucosa?", "Is there evidence of interaction between projections and microvilli, capillaries, or lacteals involved in nutrient absorption?"], "contexual_behavior": ["Does the image show structures whose swelling could indicate impaired nutrient absorption, as seen in malabsorption or inflammatory conditions?", "Are there features present that suggest reduced surface area for digestion, such as blunted or fused projections due to edema or chronic inflammation?", "Can you identify areas where fluid exchange might be compromised, possibly due to mucosal injury or persistent inflammation?", "Is there evidence of increased permeability to pathogens, which could result from disrupted tight junctions during inflammation or infection?", "Do any structures appear to have diminished enzyme secretion, potentially reflecting enterocyte dysfunction or chronic disease?", "Are there signs of altered absorptive function, such as changes in epithelial integrity or cellular turnover associated with inflammation?", "Does the image reveal reduced motility of mucosal structures, possibly due to inflammation impairing contractile activity during infection?", "Can you see indications of impaired electrolyte transport, such as might occur with mucosal damage or persistent diarrhea?", "Are there features consistent with immune-mediated damage and atrophy, as seen in celiac disease leading to malabsorption?", "Is there visual evidence of disrupted structure that could result in decreased fat absorption due to chronic inflammation or lipid transport defects?", "Do you observe increased mucus production in response to irritation, possibly from allergens, toxins, or infectious agents?", "Are there signs that regenerative capacity is impaired, such as lack of recovery after injury due to stem cell dysfunction or chronic inflammation?", "Does the image suggest ongoing epithelial loss and impaired nutrient transport, which could be associated with chronic diarrhea?", "Are there features that might indicate altered cellular metabolism or barrier dysfunction in response to toxins?", "Can you identify areas where immune defense in the gut appears reduced, possibly due to loss of immune cells or compromised mucosal immunity?"], "functions": ["Does the image show evidence of mucosal injury or inflammation within the intestinal lining?", "Can you identify features that suggest impaired nutrient absorption or disruption of the epithelial surface?", "Is there a visible reduction in the surface area available for enzymatic activity and absorption?", "Does the image indicate compromised barrier function of the intestine, such as increased permeability or susceptibility to pathogens?", "Are there signs of altered fluid balance, such as features that could be associated with diarrhea or edema?", "Can you observe indications of electrolyte imbalance, such as potential sodium or potassium loss?", "Is there evidence of impaired mucosal immune defense or increased antigen penetration in the intestinal tissue?", "Does the image suggest chronic inflammation, malabsorption, or mucosal damage consistent with intestinal disease?", "Are there visual cues of abnormal transport of nutrients or fluids across the intestinal wall?", "Can you see signs of disruption in the interaction between gut microbes and the host, such as alterations in the mucosal surface or local microenvironment?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a vessel supplying the left ventricle or left atrium that appears to originate from the pulmonary artery rather than the ascending aorta?", "Are there any signs of ischemic changes in the myocardium of the left ventricle or left atrium that could result from an abnormal arterial origin?", "Does the image reveal a vessel connected to the pulmonary artery that branches toward the interventricular septum?"], "contexual_behavior": [], "functions": ["Is there a vessel originating from the pulmonary artery that appears to supply deoxygenated blood to the heart muscle?", "Is there evidence of features that could impair the heart\u2019s response to stress or increased workload, potentially increasing the risk of arrhythmias or sudden cardiac arrest?", "Are there indications of altered pressure gradients, such as left-to-right shunting or decreased coronary perfusion pressure?"]}}, "complete hydatidiform mole": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a mass with a grape-like or vesicular appearance?", "Is there a structure present that appears pale, translucent, or white in color?", "Can you identify a lesion measuring between 5 and 20 centimeters in its greatest dimension?", "Is there an object that could weigh between 50 and 200 grams based on its size and appearance?", "Does the image display tissue with diffuse swelling of villi and no visible blood vessels?", "Can you see a structure that lacks any fetal tissue?", "Is there evidence of marked or diffuse proliferation of trophoblastic cells?", "Does the image show tissue composed of cytotrophoblasts and syncytiotrophoblasts without any fetal parts?", "Is there a region where the stroma appears edematous and hypocellular?", "Can you identify features consistent with hydropic degeneration and high water content in the tissue?", "Is there a structure that could be associated with markedly elevated levels of human chorionic gonadotropin (hCG)?", "Does the image show increased mitotic activity within the proliferating cells?", "Is there a lesion whose genetic origin could be explained by fertilization of an empty ovum by one or two sperm, resulting in a diploid, androgenetic karyotype?"], "relational": ["Does the image show abnormal proliferation of trophoblastic tissue within the uterine cavity?", "Is there evidence of markedly altered chorionic villi or trophoblastic layers in the structure occupying the uterus?", "Can you identify hydropic swelling and abnormal proliferation of chorionic villi in the tissue present?", "Does the image display proliferating cytotrophoblasts or syncytiotrophoblasts within a uterine mass?", "Is there a structure replacing normal placental tissue inside the uterus?", "Can you see a mass affecting the endometrial lining or myometrium?", "Is there involvement of the fallopian tubes or cervix by an abnormal intrauterine process?", "Does the image lack fetal structures such as the embryo, amnion, or umbilical cord within the uterine cavity?", "Is there a lesion located specifically within the uterine cavity that interacts with maternal tissues like the endometrium?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal growth characterized by excessive proliferation of trophoblastic tissue?", "Is there a structure present that indicates the absence of embryonic or fetal development within the gestational sac?", "Can you identify areas where placental tissue appears to be replaced by swollen, cystic villi lacking visible fetal blood vessels?", "Does the image suggest impaired nutrient exchange due to avascular villi or placental dysfunction?", "Is there visual evidence of a uterine enlargement that seems disproportionate for the expected gestational age?", "Can you observe features consistent with diffuse trophoblastic hyperplasia and lack of normal villous differentiation?", "Does the image contain signs that could be associated with excessive secretion of hormones such as human chorionic gonadotropin?", "Are there indications of systemic maternal effects, such as changes that might be linked to complications like preeclampsia or endocrine disturbances?", "Can you see any evidence of abnormal angiogenesis or disrupted uterine vascularization, such as swollen, avascular chorionic villi?", "Does the image reveal features that could represent a precursor lesion for gestational trophoblastic disease or suggest malignant potential?", "Is there any indication of altered maternal immune tolerance or features that might suggest increased susceptibility to immune-mediated complications?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of a chromosomal alteration that occurs in about 10\u201320% of breast cancer or myeloid malignancy cases?", "Does the image suggest a deletion spanning approximately 1 to 40 megabases, with an average size of 10 to 20 megabases?", "Can you detect decreased expression or haploinsufficiency of genes such as CBFB, CDH1, or CYLD in the sample?"], "relational": ["Is there any sign of larger chromosomal abnormalities, such as monosomy or unbalanced translocations, affecting the depicted tissues?", "Does the image show any tissues where genetic alterations might affect epithelial or renal tubular cells?", "Is there evidence of cell cycle checkpoints or DNA repair complexes in the depicted cells that could be responding to chromosomal abnormalities?"], "contexual_behavior": [], "functions": ["Do you observe abnormalities in biological pathways related to cell cycle regulation, DNA repair, or metabolism?", "Can you observe decreased expression or absence of genes typically located on a specific chromosome, leading to cellular dysregulation?", "Do any of the cells display characteristics associated with tumor suppressor loss?"]}}}
[ { "answer": "severe body burns 24 hours anasarca", "extracted_concepts": [ "severe body burns", "anasarca", "24 hours" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "severe body burns", "anasarca", "24 hours" ], "question": "does this image show severe body burns 24 hours anasarca?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "edema", "extracted_concepts": [ "edema" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "edema" ], "question": "is edema present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "edema", "extracted_concepts": [ "edema" ], "question": "what is present?" } ]	["edema", "severe body burns", "24 hours", "face", "anasarca"]	{"edema": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region where tissue appears swollen due to increased fluid volume?", "Can you identify an area that might contain fluid with a clear or pale yellow appearance?", "Is there evidence of swelling in a dependent area, such as the lower limbs or sacral region?", "Does the image suggest the presence of tissue with increased water content, possibly exceeding 80% of its weight?", "Can you see a region where the fluid accumulation could range from several hundred milliliters to several liters?", "Is there an area that might contain fluid with a composition similar to plasma, including water, electrolytes, and protein?", "Does the image show swelling that could be due to fluid with a sodium concentration similar to plasma (approximately 135\u2013145 mmol/L)?", "Can you identify a region where the fluid might have a protein content consistent with either transudate (less than 3 g/dL) or exudate (greater than 3 g/dL)?", "Is there evidence of swelling where the fluid could have a specific gravity less than 1.015 or greater than 1.015, suggesting transudate or exudate?", "Does the image suggest the presence of fluid with a neutral to slightly alkaline pH, around 7.4?", "Can you see an area where the fluid's osmolarity might be similar to plasma, about 275\u2013295 mOsm/kg?", "Is there swelling in a region where the chloride concentration of the fluid could be close to plasma levels (around 98\u2013106 mmol/L)?", "Does the image show tissue that might contain fluid with a glucose concentration similar to plasma (approximately 70\u2013100 mg/dL)?", "Can you identify an area where the temperature of the accumulated fluid would likely reflect body temperature (36\u201337\u00b0C)?", "Is there a region where the clarity of the fluid could help distinguish between transudate (clear, non-turbid) and exudate (cloudy)?", "Does the image suggest a rate of fluid accumulation that could vary from several milliliters to liters per day depending on the underlying cause?"], "relational": ["Does the image show abnormal fluid accumulation in subcutaneous tissue or mucous membranes?", "Can you identify swelling in regions such as the lower limbs, ankles, or periorbital area?", "Is there evidence of fluid buildup in interstitial tissue or body compartments like the pleural or peritoneal cavity?", "Does the image display changes in organs such as the lungs, brain, liver, or kidneys that could indicate structural impact from excess fluid?", "Can you see signs of impaired lymphatic drainage, such as distended lymphatic vessels or lymph nodes?", "Is there visible swelling that could be related to lymphatic vessel dysfunction or obstruction?", "Does the image reveal features of the cardiovascular, renal, or lymphatic systems that might be involved in abnormal fluid retention?", "Are there indications of fluid accumulation in loose connective tissue or areolar tissue?", "Can you observe any alterations in capillaries, venules, or veins that might contribute to fluid leakage?", "Is there evidence of disruption to anatomical barriers like capillary endothelium or basement membrane that could affect fluid movement?"], "contexual_behavior": [], "functions": ["Does the image show evidence of tissue swelling that could indicate increased interstitial pressure?", "Can you identify an area where excess accumulation of interstitial fluid might be present?", "Is there a region where tissue fluid balance appears disrupted, possibly due to reduced fluid reabsorption?", "Does the image display localized swelling that could be associated with increased vascular permeability?", "Can you see signs of impaired organ function that might result from altered tissue architecture or increased pressure?", "Is there visual evidence suggesting that nutrient or oxygen delivery to tissues could be compromised, such as compressed capillaries or increased diffusion distance?", "Does the image show features that might indicate overloading or obstruction of lymphatic vessels, suggesting hindered lymphatic drainage?", "Can you identify areas where wound healing appears delayed, possibly due to increased infection risk or disrupted tissue repair?", "Is there a region where cellular signaling could be altered, such as changes in tissue structure that might affect cytokine gradients?", "Does the image reveal signs of chronic inflammation or tissue damage that could facilitate fibrosis?", "Can you see indications that metabolic waste removal from tissues might be impaired, such as slowed interstitial fluid flow or compromised venous and lymphatic clearance?"]}, "no_questions": {"contexual_properties": ["Can you identify a region in the kidney that appears to have undergone tissue resorption and fibrosis, resulting in decreased size over time?", "Is there evidence of tissue shrinkage in a part of the kidney, consistent with replacement of necrotic tissue by contracted fibrous tissue?", "Does the image show a kidney region with signs of dystrophic calcification, indicating late-stage chronic infarct?"], "properties": ["Can you see an area in the kidney that might have significantly reduced oxygen levels due to loss of blood supply?", "Can you identify an area in the kidney that appears wedge-shaped, consistent with a vascular supply pattern?", "Is there a firm, fibrotic region visible in the kidney, possibly indicating scar tissue formation?"], "relational": ["Can you identify an area of tissue loss or abnormality in the cortical or medullary regions of a kidney, away from the hilum?", "Does the image show an affected area that could involve nephron components such as glomeruli, proximal tubules, loops of Henle, distal tubules, or collecting ducts?", "Can you see any abnormality adjacent to the renal capsule, perirenal fat, or renal pelvis?"], "contexual_behavior": [], "functions": ["Is there visual evidence of compensatory mechanisms, such as hyperfiltration in remaining functional units or activation of the renin-angiotensin system?", "Can you see features that might indicate impaired acid-base regulation, such as reduced capacity for acid excretion or bicarbonate reabsorption?", "Can you identify a region that might be associated with decreased urine output or oliguria due to impaired perfusion?"]}}, "severe body burns": {"yes_questions": {"contexual_properties": ["Is there an area of skin that appears discolored, possibly indicating vascular damage or tissue injury?", "Can you observe regions where the skin looks unusually dry, suggesting rapid moisture loss and barrier disruption?", "Is there visible swelling of the skin that could be due to inflammation or fluid shift?", "Do you see any blisters that may have formed within hours, possibly indicating partial-thickness injury?", "Is there evidence of decreased skin thickness, such as areas where the dermal or epidermal layers appear damaged?", "Can you identify skin that looks leathery, which might suggest early full-thickness injury?", "Is there a region where the skin appears less elastic, potentially due to collagen or elastin fiber damage?", "Do you notice any charring of the skin, which could indicate immediate exposure to high heat or flame?", "Are there areas where the skin seems to be sloughing off, possibly due to necrosis and tissue separation?", "Does the image show signs of acute fluid loss, such as extensive dryness or shriveled appearance?", "Is there visual evidence that could suggest a rapid decrease in blood volume, such as pallor or collapsed veins?", "Can you see features that might indicate dehydration, like sunken skin or increased dryness, possibly related to elevated blood sodium levels?", "Is there any indication of tissue breakdown that could be associated with early increases in blood potassium?", "Do you observe signs that might suggest a decrease in blood protein, such as edema or fluid accumulation?", "Are there areas of the skin that appear necrotic, possibly due to immediate or recent thermal injury?", "Does the affected skin appear warmer or inflamed, suggesting an acute temperature increase at the site?", "Is there a region where the skin looks dry and cracked, possibly due to moisture loss and barrier destruction?", "Can you identify hardened, darkened tissue that could represent eschar formation within hours to days?", "Are there areas where the skin seems unresponsive to touch, possibly indicating immediate loss of sensation?", "Does the wound area appear to be expanding, which might suggest ongoing tissue damage or inadequate perfusion?"], "properties": ["Does the image show areas where more than 20% of the total body surface appears affected by injury?", "Can you identify regions where tissue damage seems to extend deep beneath the skin surface, possibly into subcutaneous layers?", "Are there visible signs consistent with deep partial-thickness or full-thickness injury?", "Does the image display skin areas with a white, charred, or leathery appearance?", "Can you see regions where the wound surface looks dry and is covered by a firm, thick layer?", "Is there evidence of marked swelling, either locally or throughout the body?", "Are there visible signs suggesting the presence of significant fluid loss from the affected areas?", "Does the image show wound surfaces that might be associated with the formation of eschar within 24 to 48 hours?", "Can you identify areas where the thickness of necrotic tissue appears to be several millimeters or more?", "Are there features suggesting the loss of water content from the affected regions, possibly exceeding several liters per day?", "Does the image show wounds that could be associated with exudate volumes up to several hundred milliliters per day?", "Are there visual cues indicating systemic effects, such as widespread edema, that might accompany extensive tissue injury?"], "relational": ["Does the image show damage involving all layers of the skin, including the epidermis, dermis, and subcutaneous tissue?", "Can you identify areas where underlying structures such as muscle, tendons, or bone are exposed?", "Is there evidence of injury to both the integumentary and cardiovascular systems?", "Does the image display affected anatomical regions such as the limbs, torso, face, neck, hands, or feet?", "Can you see signs of compromised connective tissues, like disrupted collagen or elastin fibers?", "Is there visible involvement of vascular structures, such as damaged capillaries or larger blood vessels?", "Does the image suggest loss of the skin's barrier function, potentially leading to fluid imbalance or increased infection risk?", "Are there indications that underlying organs, such as muscle or bone, might be at risk?", "Can you observe any evidence of nerve involvement, such as exposure of cutaneous or peripheral nerves?", "Is there visual damage to subcutaneous fat or fascia in the affected areas?", "Does the image suggest possible compromise of the respiratory or immune systems due to the extent of injury?"], "contexual_behavior": ["Does the image show evidence of compromised barrier function that could allow pathogens to enter the body?", "Can you identify areas where fluid loss might be occurring due to the absence of protective skin layers?", "Is there visual indication of tissue damage that would increase metabolic demands for repair?", "Does the image suggest impaired thermoregulation, such as large areas lacking skin for heat retention or dissipation?", "Are there signs that immune defense mechanisms might be weakened due to loss of skin integrity?", "Can you observe features that would indicate a risk of electrolyte imbalance or fluid shifts through damaged skin?", "Does the image suggest delayed healing or impaired tissue regeneration in the affected areas?", "Are there visual cues of excessive or dysregulated inflammation in response to injury?", "Can you see evidence of impaired temperature regulation, such as destruction of insulating or sweat-producing structures?", "Does the image suggest loss of sweat glands or impaired excretion of waste products through the skin?", "Are there features indicating increased susceptibility to systemic infections or sepsis?", "Can you identify signs of impaired protein synthesis or poor tissue regeneration in the healing process?", "Does the image suggest reduced oxygen delivery to tissues, such as pallor or signs of hypoperfusion?", "Are there visual indications of altered blood flow distribution or possible shock in the body?", "Can you observe areas where the skin's ability to synthesize vitamin D might be lost due to extensive epidermal damage?", "Does the image suggest impaired sensation or loss of protective reflexes in the affected regions?", "Are there signs that could indicate an increased risk of multi-organ dysfunction or systemic complications?", "Can you identify features that might reflect disrupted hormonal responses to stress following injury?", "Does the image suggest impaired regulation of body pH, such as signs of metabolic acidosis?", "Are there indications that the skin's antimicrobial activity is decreased, increasing susceptibility to infection?"], "functions": ["Does the image show evidence of a condition that disrupts the skin barrier, leading to increased permeability and loss of protection?", "Can you identify signs of tissue exposure that would increase the risk of infection?", "Is there visual evidence of fluid loss or features suggesting electrolyte imbalance, such as extensive areas of damaged skin?", "Does the image suggest a scenario where thermoregulation might be impaired due to loss of the skin\u2019s protective function?", "Can you see signs that might indicate delayed wound healing, such as tissue necrosis or impaired regeneration?", "Is there evidence of a hypermetabolic state, such as extensive tissue damage that would increase energy and protein requirements?", "Does the image suggest a situation where cardiovascular function could be compromised by reduced blood volume or increased cardiac workload?", "Are there visual cues indicating possible airway injury or pulmonary complications, such as facial burns or involvement of the neck and chest?", "Can you identify features that might be associated with systemic inflammation or a systemic inflammatory response?", "Does the image show signs that could lead to organ dysfunction through hypoperfusion or inflammatory damage?", "Is there evidence of coagulopathy, such as areas that suggest both bleeding and clotting tendencies?", "Can you see features that would increase nutrient requirements or indicate altered nutrient utilization, such as widespread tissue catabolism?", "Does the image suggest a situation where immune defenses are compromised, increasing susceptibility to infections?"]}, "no_questions": {"contexual_properties": ["Can you see any segments of the ureter that appear more rigid, potentially from collagen deposition and fibrosis?", "Does the image show any regions where the ureter appears narrowed, possibly due to chronic inflammation or fibrotic changes?", "Are there any calcifications present along the ureter, which could be associated with chronic inflammation or infection?"], "properties": ["Can you see signs of significant luminal obstruction, with more than 50% reduction in the diameter of both ureters?", "Is there visual evidence of decreased tissue elasticity in the narrowed segments of the pelvic ureters?", "Does the image reveal moderate to severe reduction in the caliber of both pelvic ureters?"], "relational": ["Can you observe any impact on the upper urinary tract that might be related to changes in the pelvic segments of these conduits?", "Does the image show any abnormalities affecting both lower segments of the conduits that connect the kidneys to the bladder within the pelvic region?", "Does the image reveal any alterations in the walls of the paired pelvic conduits that may impact urine flow to the bladder?"], "contexual_behavior": [], "functions": ["Does the image show evidence of impaired drainage from both kidneys that could suggest urinary obstruction?", "Can you identify findings that might indicate disruption of fluid or electrolyte homeostasis?", "Is there visual indication of increased pressure within the urinary tract proximal to a narrowing?"]}}, "24 hours": {"yes_questions": {"contexual_properties": ["Does the image provide evidence of circadian variation in hormone levels such as cortisol or melatonin?", "Can you identify signs of diurnal fluctuation in body temperature across a 24-hour period?", "Is there information suggesting blood pressure changes between daytime activity and nighttime rest?", "Does the image indicate heart rate differences between waking hours and sleep within a 24-hour cycle?", "Can you observe patterns of urine output that are greater during the day and reduced at night?", "Is there evidence of blood glucose levels rising after meals and decreasing during fasting intervals over a 24-hour span?", "Does the image suggest a nocturnal peak in melatonin concentration between midnight and early morning?", "Can you identify a pattern where cortisol levels are highest in the early morning and lowest at night?", "Is there a visible difference in respiratory rate between periods of daytime activity and nighttime sleep?", "Does the image show body weight fluctuations that could be attributed to food and fluid intake or elimination within a 24-hour timeframe?", "Can you detect shifts in electrolyte balance that correspond to dietary intake, renal excretion, or hormonal regulation over 24 hours?", "Is there evidence of skin moisture levels decreasing at night and increasing during daytime activity?", "Does the image suggest slight variations in blood pH due to metabolic or respiratory activity within a 24-hour period?", "Can you observe changes in plasma volume related to hydration status, posture, or hormonal effects over a 24-hour cycle?", "Is there any indication of minimal fluctuations in oxygen saturation, with possible decreases during sleep or hypoventilation, across a 24-hour period?"], "properties": ["Does the image contain a representation of a time span equal to 86,400 seconds?", "Is there a depiction of a duration that corresponds to 1,440 minutes?", "Can you identify something that could be measured as 86,400,000 milliseconds?", "Does the image show a label or notation such as '24h'?", "Is there an indication of a period equivalent to 1 day?", "Can you see a reference to 86,400,000,000 microseconds?", "Does the image include a value of 86,400,000,000,000 nanoseconds?", "Is there a visual element using the ISO 8601 duration format 'PT24H'?", "Can you find a division of time into 96 intervals of 15 minutes each?", "Does the image display a breakdown into 48 intervals of 30 minutes?"], "relational": ["Does the image show a brain region responsible for regulating circadian rhythms?", "Can you identify a structure involved in the sleep-wake cycle?", "Is there evidence of an anatomical feature that participates in hormone secretion following a daily pattern?", "Does the image include a region of the hypothalamus associated with timekeeping in the body?", "Can you see cells or tissues, such as retinal ganglion cells, that interact with the body's timing mechanisms?", "Is there a visible structure that could be part of the central nervous system's circadian regulation?", "Does the image contain the pineal gland, which plays a role in maintaining daily rhythms?", "Can you identify neural pathways, such as the retinohypothalamic tract, that transmit timing signals?", "Is there an organ, like the liver or adrenal glands, that synchronizes its activity with daily cycles?", "Does the image show tissues or glands that might act as peripheral clocks?", "Can you see anatomical features involved in the regulation of body temperature or metabolic processes over a 24-hour period?", "Is there a structure that could influence immune responses according to a daily pattern?", "Does the image include any endocrine glands that receive input from the body's timing system?", "Can you identify neural projections from the suprachiasmatic nucleus in the image?", "Is there a visible connection between the retina and hypothalamic regions involved in circadian regulation?"], "contexual_behavior": ["Does the image suggest any evidence of biological processes that fluctuate according to circadian rhythms over a 24-hour period?", "Can you identify features that indicate diurnal variation in cellular activity or rest phases?", "Is there visual evidence of hormone secretion patterns, such as increased cortisol in the morning or melatonin at night?", "Does the image show signs of metabolic rate peaking during the daytime or decreasing at night?", "Can you observe any indications of immune system activity that might be heightened during nighttime sleep?", "Is there evidence of hepatic enzyme activity or detoxification processes that change during the night?", "Does the image suggest shifts in cardiovascular activity, such as higher blood pressure or heart rate during the day?", "Can you identify features related to the regulation of the sleep-wake cycle and its impact on physiological processes?", "Is there any indication of glucose tolerance being higher in the morning or lower at night?", "Does the image show changes in body temperature regulation, such as a low point in the early morning or a peak in the late afternoon?", "Can you observe features that might reflect fluctuations in drug metabolism efficiency due to circadian regulation?", "Is there visual evidence suggesting an increased risk of cardiovascular events, such as heart attacks, in the early morning?", "Does the image indicate variations in cognitive performance between daytime and nighttime?", "Can you see signs of tissue repair activity that might peak during nighttime sleep?", "Is there evidence of appetite regulation shifting, with increased hunger in the evening?", "Does the image suggest changes in stress hormone levels, such as a peak in cortisol secretion in the early morning?"], "functions": ["Does the image show evidence of a process that follows a daily biological cycle, such as the regulation of sleep or wakefulness?", "Can you identify any visual cues indicating fluctuations in hormone levels like melatonin or cortisol that are controlled by a biological clock?", "Is there a depiction of metabolic activity, such as glucose or lipid processing, that might vary depending on the time of day?", "Does the image suggest changes in body temperature that could be associated with circadian variation?", "Can you see any signs of physiological regulation, such as alertness or digestion, that are influenced by a daily biological rhythm?", "Is there evidence of immune system activity that might be heightened or suppressed according to a daily cycle?", "Does the image show cellular repair processes, such as DNA repair or protein synthesis, that are typically coordinated with periods of sleep?", "Can you observe cardiovascular features, like heart rate or blood pressure, that might reflect daily rhythmic changes?", "Is there any indication of appetite regulation or digestive activity that could be modulated by a daily biological rhythm?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show attachment points for membranes such as the dura mater, arachnoid mater, or pia mater?", "Is there evidence of large openings like the foramen magnum or smaller foramina such as the jugular foramen, foramen ovale, or hypoglossal canal?", "Does the image suggest the presence of nerves such as the olfactory, optic, or trigeminal nerves traversing through bony openings?"], "contexual_behavior": ["Is there a region where tumor invasion could encase or compress major blood vessels, potentially affecting vascular flow?", "Does the image reveal any defects that could allow pathogens to enter the cranial cavity from the paranasal sinuses or middle ear?", "Can you identify any pathways by which infection from the middle ear could extend to the petrous part of the temporal bone or inner ear structures, potentially affecting hearing?"], "functions": ["Is there evidence of a region contributing to the overall stability and shape of the head by connecting cranial bones?", "Can you identify an area involved in transmitting sound vibrations through the temporal bone to the inner ear?", "Can you see any attachment points for muscles involved in chewing or swallowing?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": ["Can you observe cellular atypia or irregular cell shapes that might be present in neoplastic conditions like choriocarcinoma?", "Are there visible structural changes consistent with pathological remodeling, such as those found in trophoblastic tumors?", "Is there evidence of excessive tissue growth, possibly indicating a gestational trophoblastic neoplasm or complete mole?"], "properties": ["Is there a visible indication of active cell division in the epithelial covering of the chorion?", "Can you identify regions where the surface layer of the chorion appears thicker than usual?", "Does the image show evidence of increased cell numbers in the outermost fetal membrane?"], "relational": ["Does the image show a region that forms the outermost fetal layer of the placenta?", "Does the image show a tissue that interacts with the decidua basalis or maternal blood spaces?", "Does the image contain layers such as cytotrophoblast and syncytiotrophoblast?"], "contexual_behavior": ["Is there a visible indication of abnormal growth or expansion in the tissue covering the fetal side of the placenta?", "Can you identify regions where the epithelial layer of the chorion appears thicker or denser than usual?", "Does the image show evidence of increased cellular activity in the outermost fetal membrane?"], "functions": ["Can you observe areas that may correspond to hormone-secreting trophoblasts, potentially indicating active hormone regulation during pregnancy?", "Does the image suggest an increased number of cells involved in nutrient transfer between maternal and fetal compartments?", "Does the image provide visual cues of active cell proliferation, differentiation, or tissue remodeling within placental structures?"]}}, "anasarca": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a person with diffuse, symmetrical swelling throughout the subcutaneous tissues of the entire body?", "Can you observe skin that appears swollen, stretched, and shiny due to extensive fluid retention?", "Is there evidence of significant weight gain, possibly in the range of 5 to 20 kilograms or more?", "Does the image display limbs with noticeably increased circumference, potentially by 5 to 10 centimeters or more?", "Can you see areas where pressing on the swollen skin would likely result in a pitting depth greater than 1 cm?", "Is the swelling present in the image likely to persist for days to weeks if untreated?", "Does the affected skin appear pale or slightly translucent while maintaining a normal or cool temperature?", "Can you identify decreased skin turgor, such that the skin would return slowly after being pinched?", "Is there visual evidence suggesting a marked increase in tissue water content, possibly exceeding 70% of tissue weight?", "Does the image show swelling with a normal capillary refill time, typically less than 2 seconds?"], "relational": ["Does the image show evidence of widespread fluid accumulation in the subcutaneous tissue?", "Can you identify swelling that affects multiple regions such as the limbs, face, abdomen, or trunk?", "Is there visible involvement of tissues like connective or interstitial tissue with signs of fluid retention?", "Does the image display changes in the skin or mucous membranes that could be due to fluid buildup?", "Can you see features suggesting impaired lymphatic drainage or lymphatic dysfunction?", "Is there visual evidence of increased capillary permeability or venous congestion in the depicted structures?", "Does the image show alterations in organs such as the liver, kidneys, heart, or lungs that might be related to fluid overload?", "Can you identify swelling that appears to involve the extracellular or interstitial compartments?", "Are there signs of anatomical barriers, such as capillary endothelium or lymphatic vessels, being affected by fluid accumulation?"], "contexual_behavior": [], "functions": ["Does the image show evidence of widespread swelling that could indicate generalized fluid accumulation throughout the body?", "Can you identify signs of excessive interstitial fluid that suggest disruption of normal fluid balance?", "Is there visible swelling that might be due to increased capillary permeability or fluid overload?", "Does the image reveal tissue changes that could result in impaired perfusion or cellular dysfunction?", "Can you observe any features suggesting that organ function might be compromised by external pressure from surrounding tissues?", "Is there evidence of increased distance between capillaries and cells that could impair nutrient or oxygen delivery?", "Does the image show signs of lymphatic congestion or impaired drainage, such as extensive swelling that could indicate lymphedema?", "Can you identify visual cues that might suggest cardiovascular strain, such as signs consistent with increased preload or heart failure?", "Is there any indication of delayed wound healing or impaired tissue repair, possibly due to edematous tissue?", "Does the image suggest reduced mobility or physical limitation as a result of extensive swelling or discomfort?", "Can you see any areas where the skin appears stretched, at risk for breakdown, ulceration, or infection?"]}, "no_questions": {"contexual_properties": ["Can you observe changes in the consistency of a discharge that might reflect shifts in cellular content, protein concentration, or fluid balance during infection progression?", "Is there a brownish tint to any exudate, suggesting the presence of degraded blood products or chronic infection?", "Does the image show a collection that could contain a high number of bacteria, indicating active or uncontrolled infection?"], "properties": ["Can you identify a substance that could have high concentrations of inflammatory mediators like cytokines or chemokines?", "Does the image show a substance that appears yellow, green, or white?", "Does the image show a collection whose volume could range from a few milliliters to over a hundred milliliters?"], "relational": ["Can you identify a region that might contain neutrophils or dead macrophages?", "Is there a visible accumulation that could be associated with bacteria within tissue spaces or wounds?", "Does the image show evidence of acute inflammation in tissues such as the skin, lungs, or mucous membranes?"], "contexual_behavior": ["Is there evidence of poor wound healing or chronic wounds that might be associated with diabetes mellitus and increased accumulation?", "Does the image show changes in the appearance of the accumulation that could correspond to different stages of infection, such as varying cellular or protein content?", "Can you see persistent accumulation that could be due to impaired phagocytosis or chronic infection, possibly in an immunocompromised individual?"], "functions": ["Does the image display material that might be associated with the drainage of infected tissue or removal of pathogens?", "Can you identify an accumulation that suggests the recruitment of neutrophils or other immune cells at a site of inflammation?", "Is there an area that appears to be clearing necrotic tissue or promoting the resolution of inflammation?"]}}}
[ { "answer": "absence of palpebral fissure cleft palate", "extracted_concepts": [ "absence of palpebral fissure", "cleft palate", "large head" ], "question": "what large head see protocol for details?" }, { "answer": "head see protocol for details", "extracted_concepts": [ "head", "palpebral fissure", "protocol", "cleft palate", "absence of palpebral fissure" ], "question": "what does absence of palpebral fissure cleft palate see?" }, { "answer": "yes", "extracted_concepts": [ "head", "absence of palpebral fissure", "cleft palate", "protocol" ], "question": "does absence of palpebral fissure cleft palate see head see protocol for details?" }, { "answer": "absence of palpebral fissure cleft palate large head see protocol for details", "extracted_concepts": [ "absence of palpebral fissure", "cleft palate", "large head" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "absence of palpebral fissure", "cleft palate", "large head" ], "question": "does this image show absence of palpebral fissure cleft palate large head see protocol for details?" }, { "answer": "complex craniofacial abnormalities", "extracted_concepts": [ "complex craniofacial abnormalities" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "complex craniofacial abnormalities" ], "question": "is complex craniofacial abnormalities present?" }, { "answer": "yes", "extracted_concepts": [ "absence of palpebral fissure", "cleft palate", "protocol" ], "question": "does absence of palpebral fissure cleft palate see protocol for details?" }, { "answer": "absence of palpebral fissure cleft palate", "extracted_concepts": [ "palpebral fissure", "absence of palpebral fissure", "cleft palate", "protocol" ], "question": "what see protocol for details?" }, { "answer": "protocol for details", "extracted_concepts": [ "absence of palpebral fissure", "cleft palate" ], "question": "what does absence of palpebral fissure cleft palate see?" }, { "answer": "complex craniofacial abnormalities", "extracted_concepts": [ "complex craniofacial abnormalities" ], "question": "what is present?" } ]	["large head", "head", "palpebral fissure", "protocol", "complex craniofacial abnormalities", "cleft palate", "absence of palpebral fissure"]	{"large head": {"yes_questions": {"contexual_properties": ["Does the image show an individual with features that could indicate rapid brain growth or macrocephaly?", "Can you observe a head whose size appears disproportionate to the body, possibly suggesting a recent growth spurt or unresolved swelling?", "Is there evidence of cranial shape changes that might be associated with craniosynostosis, trauma, or developmental disorders?", "Does the head display signs of abnormal swelling that could be due to hydrocephalus, infection, or trauma?", "Are there visible changes in the bone structure of the head that might suggest craniosynostosis, a metabolic bone disease, or a genetic syndrome?", "Can you identify any asymmetry of the head that could be related to cranial deformities, positional plagiocephaly, or unilateral swelling?", "Is there visual evidence of increased fluid accumulation within the head, as might occur in hydrocephalus or subdural effusion?", "Does the head show discoloration that could be consistent with bruising, infection, or vascular malformations?", "Are there abnormal soft spots on the head that might indicate delayed fontanelle closure or increased intracranial pressure?", "Can you observe changes in head circumference that could be associated with a growth spurt, macrocephaly, or pathological swelling?", "Does the head appear unusually heavy or enlarged, possibly due to increased tissue mass, fluid accumulation, or abnormal growths?", "Is there evidence of abnormal tissue growth on the head, such as tumors, cysts, or signs of overgrowth syndromes?", "Can you see changes in the skin texture of the head that might suggest edema, infection, or a dermatological condition?", "Does the head appear more rigid than expected, potentially indicating premature suture closure or a calcification disorder?", "Are there visual cues of increased pressure within the head, such as those seen in hydrocephalus, intracranial hemorrhage, or space-occupying lesions?"], "properties": [], "relational": ["Does the image show a region containing both the cranium and the face?", "Can you identify an area that includes the scalp and jaw?", "Is there a structure composed of bones such as the frontal bone, parietal bones, or mandible?", "Does the image contain features associated with the maxilla or zygomatic bones?", "Can you see evidence of the nervous system or sensory system within a single anatomical region?", "Is there a visible area that could house the oral cavity as part of the digestive system?", "Does the image display muscles such as the temporalis, masseter, or frontalis?", "Can you identify regions where the orbicularis oculi or orbicularis oris muscles are present?", "Is there a structure that could contain nerves like the facial nerve or trigeminal nerve?", "Does the image show pathways for the optic or olfactory nerves?", "Can you see blood vessels such as the external carotid artery or jugular veins supplying a prominent region?", "Is there an area where the superficial temporal artery or facial artery might be found?", "Does the image include organs such as the brain, eyes, or ears within a single structure?", "Can you identify a region containing the nose, tongue, or salivary glands?", "Is there a visible connection between a large anatomical region and the neck, possibly involving occipital condyles or cervical vertebrae?", "Does the image show an area where the atlanto-occipital joint or neck muscles attach?", "Can you see tissues such as bone, muscle, or nervous tissue concentrated in a single region?", "Is there evidence of connective or epithelial tissue forming part of a prominent structure?", "Does the image display cavities such as the cranial cavity or oral cavity within a large anatomical area?", "Can you identify the presence of orbital cavities, nasal cavity, or paranasal sinuses in a single region?"], "contexual_behavior": [], "functions": ["Does the image show an individual with features suggesting increased cranial volume?", "Is there evidence of altered biomechanics or postural adaptation related to head size?", "Can you observe signs that might indicate enhanced physical protection for the brain, such as increased skull thickness?", "Does the image suggest atypical neurological development, such as differences in cognitive or motor skills?", "Are there visible changes in the spatial arrangement of sensory organs that could affect sensory processing or integration?", "Is there any indication of challenges with cranial pressure regulation, such as features associated with intracranial hypertension?", "Does the subject appear to be in an age group, such as infancy, where rapid brain growth and neurodevelopment are prominent?", "Can you see signs of altered balance or motor coordination, possibly due to a shifted center of gravity?", "Is there evidence of mechanisms for enhanced heat dissipation or thermoregulation around the head?", "Do the upper airway structures appear affected in a way that could influence breathing or airway function?", "Are there musculoskeletal adaptations visible, such as prominent neck muscles or changes in posture, that might compensate for head size?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify cartilage structures such as septal cartilage, lateral nasal cartilage, or alar cartilage within the section?", "Is there evidence of cell types like epithelial cells, chondrocytes, osteocytes, fibroblasts, or endothelial cells in the depicted structure?", "Is there an object present that could weigh between 10 and 20 grams based on its size and tissue composition?"], "relational": ["Can you identify an anatomical view that separates the left and right halves of both the external and internal nose?", "Does the image display tissues such as mucosa, cartilage, bone, and skin within the same section?", "Are vascular structures such as branches of the sphenopalatine artery, facial artery, or anterior ethmoidal artery visible in the sectioned area?"], "contexual_behavior": [], "functions": ["Is there visible disruption of the mucosal lining that could compromise mucociliary clearance or increase infection risk?", "Can you identify a modification that would allow for enhanced visualization or instrumentation of deep nasal regions?", "Is there evidence of a procedure that could disrupt the continuity of the nasal passages, potentially causing airflow obstruction or turbulence?"]}}, "head": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with an ovoid or ellipsoid shape?", "Can you identify an object whose size could be approximately 22 cm in length and 17 cm in width in adults?", "Is there a structure present that might weigh around 4.5 to 5 kg in an adult?", "Can you see something with a circumference likely between 54 and 58 cm?", "Does the image contain an object with an estimated volume of about 1.3 to 1.5 liters?", "Is there a visible area where the skin color ranges from pale to dark brown depending on pigmentation?", "Can you identify a region where the bone density could be around 1.5 to 2.0 g/cm\u00b3?", "Is there a structure that might contain about 70% water by weight?", "Can you see an area where fat content could account for 10% to 15% of total weight?", "Does the image show a region where the scalp thickness is likely between 5 and 7 mm?", "Is there a structure composed of bone, muscle, skin, nervous tissue, connective tissue, and adipose tissue?", "Can you identify an area where the temperature would be approximately 36.5 to 37.5\u00b0C?", "Does the image show a region with dense hair, possibly 200 to 300 hairs per cm\u00b2?", "Is there a structure that could contain minerals such as calcium, phosphorus, and magnesium in its bony component?", "Can you see an area where the skin pH might be between 4.5 and 5.5?", "Is there a structure that could be made up of 22 bones in an adult?", "Can you identify a region with high oxygen consumption, likely due to brain metabolism?", "Does the image show an area with a high concentration of sensory receptors, especially in the lips or tongue?", "Is there a structure that receives significant blood flow, approximately 750 ml/min?", "Can you see a region where the proportion of gray to white matter might be about 1.3:1?"], "relational": ["Does the image show a region containing components of the nervous system?", "Is there a structure present that includes elements of the musculoskeletal system?", "Can you identify an area that contains organs of the sensory system?", "Does the image include any part of the respiratory or digestive systems within a single region?", "Are there visible bones such as the cranium, mandible, or maxilla?", "Can you see features corresponding to the zygomatic, nasal, or temporal bones?", "Is there a region that includes the occipital, parietal, or frontal bones?", "Does the image show a compartment that could contain the brain?", "Are there visible structures corresponding to the eyes, ears, or nose?", "Can you identify an area that might contain the tongue or salivary glands?", "Is there a region that could be classified as the cranial cavity, facial region, or oral cavity?", "Does the image show an area that could be the nasal or orbital cavity?", "Are there muscles present such as the masseter, temporalis, or frontalis?", "Can you see features corresponding to the orbicularis oculi, orbicularis oris, or buccinator muscles?", "Is there evidence of nerves such as cranial nerves, trigeminal nerve, or facial nerve passing through this region?", "Does the image show structures that could be innervated by the optic, olfactory, glossopharyngeal, or vagus nerves?", "Are there visible blood vessels such as the carotid arteries, vertebral arteries, or jugular veins?", "Can you identify arteries like the facial artery or superficial temporal artery in the region?", "Is there a connection to the neck via structures such as the atlanto-occipital joint or foramen magnum?", "Does the image show features that could be associated with cervical vertebrae or neck muscles?", "Are there sensory organs such as the eyes, ears, nose, or tongue present in the region?", "Can you see cavities such as the cranial cavity, nasal cavity, oral cavity, or orbital cavity?", "Is there evidence of the middle ear cavity or paranasal sinuses in the image?"], "contexual_behavior": ["Does the image show a structure that would exhibit reduced sensory processing during sleep in the NREM stages?", "Is there evidence of impaired coordination that could result from disrupted neural pathways after a traumatic injury?", "Can you identify a region where increased blood flow might occur during cognitive activity to meet metabolic demands?", "Does the image contain a structure that could lose its ability to regulate temperature in the event of heatstroke due to hypothalamic dysfunction?", "Is there a feature that could experience altered pain perception during a migraine as a result of trigeminovascular pathway sensitization?", "Can you see an area where neural activity would decrease under anesthesia due to suppressed central nervous system signaling?", "Is there a structure that might fail to maintain balance after vestibular dysfunction involving the inner ear or brainstem pathways?", "Does the image show a region where intracranial pressure could increase during infection as inflammation and edema develop?", "Is there a part that could demonstrate impaired speech production after a stroke affecting language centers?", "Can you identify an area that would show reduced oxygen supply in hypoxic conditions when arterial oxygen levels fall?", "Is there a structure that might alter its sensory integration during sensory overload due to overstimulated neural circuits?", "Does the image show a region that could experience diminished reflex responses as neuronal degeneration progresses in neurodegenerative disease?", "Is there a part that would increase metabolic demand during mental stress as neuronal activity and glucose consumption rise?", "Can you see evidence of impaired eye movement coordination that could result from disruption of oculomotor pathways after concussion?", "Is there a region that could show impaired thermoregulation in hypothalamic disorders when temperature control centers are affected?"], "functions": ["Does the image show a structure that houses multiple sensory organs such as those for vision, hearing, smell, taste, or touch?", "Can you identify a region that protects a major neural organ within a bony cavity?", "Is there a part visible that enables communication through speech or facial expressions?", "Does the image contain structures responsible for sensory integration, such as eyes, ears, nose, tongue, or skin?", "Can you see evidence of a bony structure that safeguards neural tissue?", "Is there a region that facilitates feeding and swallowing by coordinating the mouth, jaws, tongue, or pharynx?", "Does the image include features associated with balance and orientation, such as the vestibular system or inner ear?", "Can you identify an area that assists with breathing or olfaction by containing a nasal cavity or respiratory passages?", "Is there a structure that enables facial expression via the action of muscles controlled by cranial nerves?", "Does the image show components involved in hearing, such as the auricle, tympanic membrane, or cochlea?", "Can you see organs responsible for vision and eye movement, including extraocular muscles or the optic nerve?", "Is there evidence of taste sensation through the presence of a tongue or palate?", "Does the image reveal structures that contribute to speech production, such as the larynx, vocal cords, tongue, lips, or jaw?"]}, "no_questions": {"contexual_properties": ["Does the image show a lesion within a ductal structure that contains multiple papillary projections?", "Can you identify a ductal abnormality characterized by the presence of multiple papillary growths and areas resembling apocrine metaplasia?", "Is there evidence of epithelial changes within a ductal lesion that suggest transformation toward apocrine cell characteristics?"], "properties": ["Does the image contain a lesion with numerous delicate papillary fronds within dilated ducts?", "Can you see a region where the Ki-67 proliferation index would likely be low?", "Is there a structure ranging from a few millimeters up to several centimeters in size?"], "relational": ["Are there regions containing epithelial cells, myoepithelial cells, or apocrine cells?", "Is there evidence of changes within lactiferous ducts or terminal duct-lobular units?", "Does the image reveal structures supported by a myoepithelial layer, basement membrane, or surrounding stroma?"], "contexual_behavior": ["Is there evidence of multiple papillary projections inside a ductal space?", "Does the image contain features suggestive of epithelial proliferation within a duct?", "Does the image show any abnormal growths within a ductal structure?"], "functions": ["Can you observe replacement of typical ductal epithelium by cells with apocrine characteristics?", "Does the image suggest increased or modified secretion within the ducts?", "Does the image show evidence of benign epithelial proliferation within a ductal structure?"]}}, "palpebral fissure": {"yes_questions": {"contexual_properties": ["Does the image show an area that appears wider than usual, possibly due to eyelid retraction or sympathetic activation?", "Can you identify a region that looks narrower, which might be caused by ptosis or contraction of the orbicularis oculi muscle?", "Is there evidence of a shape change in the space between the eyelids, as might be seen in congenital syndromes, trauma, or facial nerve palsy?", "Does the image reveal asymmetry between the left and right sides, potentially due to unilateral ptosis, facial nerve paralysis, or an orbital mass?", "Can you observe swelling in the region around the eyes, which could indicate periorbital edema, an allergic reaction, or cellulitis?", "Is there a visibly smaller opening between the eyelids, possibly resulting from blepharospasm, severe ptosis, or recent eyelid surgery?", "Does the area between the eyelids appear elongated, as might be seen in Down syndrome, craniofacial dysmorphism, or lateral canthal dystopia?", "Can you detect a shortened space between the eyelids, which could be due to medial canthal tendon abnormality, trauma, or surgical intervention?", "Is there any discoloration, such as bruising or ecchymosis, in the area bordered by the eyelids?", "Do you see abnormal margins or irregularities along the eyelid borders, which might be caused by chronic blepharitis, scarring, or a tumor?", "Is there a change in the orientation of the opening between the eyelids, as could occur in congenital syndromes, craniofacial anomalies, or after reconstructive surgery?", "Does the area between the eyelids appear red, suggesting conjunctivitis, inflammation, or increased vascularity?", "Can you observe edema in the eyelid region, possibly due to allergic reaction, infection, or systemic fluid overload?", "Are there visible signs of inflammation, such as redness or swelling, in the space bordered by the eyelids, which could be related to blepharitis, conjunctivitis, or autoimmune disorders?", "Is there evidence of abnormal tissue growth, such as a neoplasm or papilloma, within the area between the eyelids?"], "properties": ["Does the image show an almond-shaped or elliptical opening between the eyelids?", "Can you identify an opening with a length between 27 and 30 millimeters?", "Is there a structure with a width or vertical height of approximately 8 to 10 millimeters?", "Does the image display a gentle upward arc toward the outer corner of the eye?", "Is there an opening where the outer corner is 1\u20132 millimeters higher than the inner corner?", "Can you see a feature whose orientation is parallel or slightly inclined upward relative to the horizontal plane?", "Are the margins of the opening similar in color to the surrounding eyelid skin, appearing light pink or pale?", "Does the distance between the inner and outer corners of the opening measure about 28 to 30 millimeters?", "Is there bilateral symmetry, with both sides showing equal size and shape of the opening between the eyelids?"], "relational": ["Is there an opening within the orbital region of the face that is bordered by the upper and lower eyelids?", "Can you identify a space whose boundaries are formed by the margins of the upper and lower eyelids?", "Does the image show an area where the eyelid skin, conjunctiva, and orbicularis oculi muscle are adjacent?", "Is there a visible opening between the eyelids through which the cornea, sclera, or iris can be seen?", "Can you observe a region that exposes the anterior surface of the eyeball, particularly the cornea?", "Is there an external opening of the orbit that allows communication between the eye and the external environment?", "Does the image contain anatomical landmarks such as the medial canthus and lateral canthus at the ends of an eyelid opening?", "Can you see a structure whose size or shape might be influenced by muscles like the levator palpebrae superioris, orbicularis oculi, or M\u00fcller's muscle?", "Is there a feature in the image that interacts with the ocular, muscular, and integumentary systems?"], "contexual_behavior": ["Does the image show any evidence of eyelid narrowing that could be related to neuromuscular dysfunction, such as ptosis or oculomotor nerve palsy?", "Is there a visible widening of the space between the eyelids that might suggest sympathetic activation or contraction of the superior tarsal muscle?", "Can you identify signs of fatigable eyelid weakness, as might be seen in myasthenia gravis?", "Is there any indication of eyelid swelling or edema that could cause narrowing, possibly due to an allergic reaction?", "Does the image depict closed eyelids, as would occur during sleep or normal physiological eyelid closure?", "Is there evidence of incomplete eyelid closure, which could suggest lagophthalmos or eyelid dysfunction?", "Can you observe signs of impaired orbicularis oculi muscle function, such as reduced eyelid opening, that might be associated with facial nerve palsy?", "Is there abnormal widening of the eyelid opening that could be related to eyelid retraction in thyroid eye disease?", "Does the image show narrowing of the eyelid opening as a protective reflex to ocular pain, such as blepharospasm?", "Are there visible changes in eyelid position or movement that might correspond to emotional expressions like surprise or sadness?", "Can you detect asymmetry in the eyelid openings that could be due to trauma, swelling, or muscle injury?", "Is there evidence of squinting or narrowing of the eyelid opening in response to bright light or photophobia?", "Does the image show widened eyelid openings that could be associated with surprise, fear, or sympathetic activation?", "Are there signs of eyelid swelling or decreased opening due to inflammation or injury?", "Can you identify features suggestive of congenital syndromes, such as blepharophimosis or Down syndrome, that affect eyelid function or shape?"], "functions": ["Is there a visible opening that allows light to reach the cornea for clear vision?", "Can you identify a structure that enables the eyelids to close fully, protecting the eye from injury?", "Does the image show a feature that ensures even tear distribution across the eye surface during blinking?", "Is there an opening whose width can regulate the amount of light entering the eye?", "Can you see a structure that facilitates blinking and helps lubricate the ocular surface?", "Is there a feature that maintains moisture and prevents the eye surface from drying out?", "Does the image include an opening that acts as a barrier against dust and foreign particles?"]}, "no_questions": {"contexual_properties": ["Is there evidence of tortuosity in a vessel, which may be associated with aging or congenital anomalies?", "Can you observe increased stiffness in a vessel, which might be due to fibrosis or vascular calcification?", "Does the image show a vessel wall that appears thickened, which could result from chronic inflammation or hypertension?"], "properties": ["Does the tissue of any vessel appear to have a water content of about 70-80% by weight?", "Is there a structure that would typically experience pressures between 80 and 120 mmHg during the cardiac cycle?", "Can you identify a structure with a length ranging from about 10 to 100 millimeters, depending on its branch?"], "relational": ["Can you identify a structure adjacent to the pericardium?", "Can you see a vessel that gives rise to the right marginal artery?", "Can you see a vessel that penetrates the epicardium or myocardium?"], "contexual_behavior": ["Can you identify a structure whose blood flow might decrease during physical exertion if there is evidence of narrowing or obstruction?", "Can you see a vessel that would deliver less oxygen to the heart muscle during anemia because of reduced arterial oxygen content?", "Does the image contain a vessel that could lose its ability to adapt to exercise-induced stress if atherosclerosis or microvascular disease is present?"], "functions": ["Can you see evidence of a system that facilitates venous drainage from the heart muscle?", "Does the image show a structure capable of regulating blood flow to the heart through changes in vessel diameter?", "Is there evidence of endothelial-mediated vasodilation or metabolic regulation in the vessels supplying the heart?"]}}, "protocol": {"yes_questions": {"contexual_properties": ["Is there evidence that the amount of a substance administered has been altered in response to patient reactions or toxicity?", "Can you identify a change in the method of administration that might be related to efficacy or safety concerns?", "Does the image suggest that the duration of a process has been extended due to unmet therapeutic goals or the need for prolonged exposure?", "Is there an indication that the duration of a procedure has been shortened because of adverse effects or early achievement of endpoints?", "Can you observe additional monitoring steps that might be implemented due to increased risk or new safety concerns?", "Is there visual evidence of more frequent measurements being taken, possibly in response to rapid changes in clinical status or analyte levels?", "Does the image show a change in how often interventions are performed, potentially reflecting patient progress or interim analysis findings?", "Can you see any alteration in the composition of substances being administered, possibly due to formulation changes or stability issues?", "Is there an indication that temperature conditions have been adjusted to optimize reaction rates or ensure stability?", "Does the image suggest a change in the volume of samples collected, perhaps to meet analytical sensitivity or assay requirements?", "Can you identify adjustments in the timing of sample collection that might align with pharmacokinetic profiles or circadian rhythms?", "Is there evidence of different storage conditions being used to maintain sample integrity or address biosafety considerations?", "Does the image show a change in the concentration of reagents, possibly for assay optimization or increased sensitivity?", "Can you observe additional or fewer procedural steps, potentially reflecting updates in process efficiency or regulatory compliance?", "Is there a visible change in equipment settings that could be related to calibration or modified technical specifications?", "Does the image indicate a change in the physical form of a substance, perhaps to improve solubility or delivery method?", "Can you see more stringent sterility measures being implemented, possibly due to increased infection risk or the use of sensitive biological materials?", "Is there evidence that the number of cycles or repetitions in a process has been adjusted to meet experimental design or statistical power requirements?", "Does the image suggest a change in the measurable endpoints being tracked, possibly in response to revised study objectives or new regulatory guidance?", "Can you identify adjustments in the interval between procedures that might be based on recovery time or pharmacodynamic considerations?"], "properties": ["Is there evidence of a procedure that involves multiple sequential steps, possibly between 5 and 20?", "Can you identify any indication of a process where the duration might range from minutes to several hours?", "Does the image suggest the use of reagents measured in microliters or milliliters, such as volumes between 10 \u00b5L and 1 mL?", "Is there a visual cue indicating that solutions with specific concentrations, for example between 0.1 M and 1 M, are being used?", "Can you see any reference to temperature control within the range of 2\u00b0C to 37\u00b0C?", "Is there any indication that the pH is maintained between 6.0 and 8.0 for a particular process?", "Does the image suggest that individual steps might have defined time intervals, possibly from seconds to several hours?", "Is there evidence that the total completion time for a process could be less than an hour or extend to several days?", "Can you identify any equipment or labeling that suggests pressure settings such as 1 atm or 15 psi are being used?", "Is there any sign that measurement accuracy is important, with an error margin of \u00b15% or less?", "Does the image indicate the use of multiple replicates or samples, possibly ranging from 3 to 100 or more?", "Can you see any reference to storage conditions, such as specific temperatures like 4\u00b0C or -20\u00b0C, humidity control, or protection from light?", "Is there evidence of measurements being taken at specific wavelengths, such as 260 nm or 600 nm?", "Does the image suggest the use of mixing or agitation at rates between 300 rpm and 1200 rpm?", "Can you identify any indication that samples are incubated for periods ranging from minutes to overnight?"], "relational": ["Does the image depict a process or procedure such as diagnostic testing or therapeutic administration that appears to be organized in a structured manner?", "Can you identify a clinical workflow, like emergency response or medication management, that seems to follow a set of defined steps?", "Is there evidence of steps such as eligibility assessment, intervention, or outcome evaluation being followed in the depicted scenario?", "Does the image show a medical intervention, such as drug administration or surgical procedures, that appears to be coordinated according to a set of instructions?", "Are there healthcare professionals, such as nursing staff or physicians, interacting in a way that suggests adherence to a structured process?", "Can you see elements of patient care pathways, such as preoperative or postoperative management, that indicate a standardized approach?", "Is there visible documentation, such as consent forms or checklists, that would be associated with a structured medical process?", "Does the scene include references to related procedures, such as standard operating procedures or clinical guidelines, being followed?", "Are there medical devices or equipment, like infusion pumps or monitoring devices, being used in a way that suggests compliance with a set of instructions?", "Can you identify anatomical procedures, such as venipuncture or catheterization, being performed in a manner that appears standardized?"], "contexual_behavior": ["Is there evidence of a process that could fail to ensure accurate data collection due to unclear procedures or lack of standardized data entry?", "Can you identify a scenario where procedures might require modification because of unexpected safety concerns or adverse events?", "Is there an indication that patient safety monitoring is increased during high-risk procedures based on risk assessment findings?", "Does the process shown reduce the frequency of follow-up assessments for patients who are clinically stable over time?", "Is there a situation where rigid procedures might delay urgent decision-making, making the process less effective in emergency medical situations?", "Can you see features that would improve compliance in individuals with chronic diseases, such as simplified regimens or patient-centered support?", "Is there evidence that standardization across multiple sites could be compromised by inconsistent implementation or interpretation?", "Does the process include extended monitoring periods or large, diverse participant groups to enhance detection of rare side effects during drug testing?", "Is there an adaptation of procedures to account for differences between pediatric and adult populations, such as age-specific physiological or ethical considerations?", "Can you detect any indication that blinding might be compromised in a double-blind study due to procedural lapses or unintentional disclosures?", "Is there a streamlined approach or use of validated, low-cost methods to increase diagnostic accuracy in resource-limited settings?", "Does the process appear less effective due to signs of poor participant adherence, possibly from complex instructions or insufficient support?", "Is there evidence that data collection methods have been updated in response to new technological tools or platforms?", "Can you identify the integration of validated digital assessment tools or clear communication strategies to improve outcome measurement during remote or telemedicine interventions?", "Is there a sign that reliability is reduced when multiple diseases are present, possibly because standard procedures do not account for comorbid conditions?"], "functions": ["Does the image depict a scenario where structured instructions are being followed to guide a medical or laboratory procedure?", "Can you identify evidence of step-by-step actions or specified materials and conditions being used in a clinical or experimental workflow?", "Is there visual indication of uniform methods or criteria being applied to ensure standardization in diagnosis, treatment, or experimentation?", "Does the scene suggest the presence of safety measures, such as error prevention steps or emergency procedures, to protect patient safety during treatment?", "Can you observe a sequence or order of medical interventions being regulated, such as timing or the arrangement of steps in patient management?", "Is there evidence that the actions being performed are documented in a way that would support reproducibility and consistency in biomedical experiments?", "Does the image show coordination among multidisciplinary healthcare team members, with clear role definition or communication pathways?", "Can you see processes or documentation related to quality assurance, such as criteria for data collection, monitoring, or reporting in a clinical trial setting?", "Is there visual evidence of patient monitoring, such as assessment schedules, outcome measures, or adjustments to interventions based on feedback?", "Does the scene suggest that procedures are being conducted in alignment with regulatory, ethical, or legal standards, indicating compliance with institutional requirements?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of a structure that could form either exocrine or endocrine glands?", "Can you identify tissue that appears to be a specialized form of epithelial tissue adapted for secretion?", "Is there a region in the image, such as the neck, abdomen, breast, or oral cavity, that contains specialized tissue for secretion?"], "contexual_behavior": [], "functions": ["Does the image include a structure that participates in endocrine signaling by releasing hormones directly into the blood?", "Does the image show a structure involved in the secretion of hormones or enzymes?", "Can you see a structure that aids digestion by releasing digestive enzymes or fluids into the gastrointestinal tract?"]}}, "complex craniofacial abnormalities": {"yes_questions": {"contexual_properties": ["Does the image show facial features that appear more pronounced or altered, suggesting changes that might become evident during periods of rapid growth such as childhood or puberty?", "Can you observe increased asymmetry in the facial structures that could indicate progression of an underlying developmental or genetic disruption?", "Is there evidence of additional or irregular bone growth in the craniofacial region, possibly due to abnormal bone remodeling or pathological ossification?", "Do the facial proportions in the image appear altered, as might occur with abnormal development of craniofacial bones or soft tissues?", "Are there visible changes in the composition of facial tissues, such as unusual distribution or thickness of connective, muscular, or adipose tissue?", "Does the image reveal areas of swelling in the face that could be consistent with acute inflammation, infection, or trauma?", "Can you identify regions of the face with abnormal skin color, such as redness, pallor, or unusual pigmentation, that might suggest vascular malformations or pigmentation disorders?", "Is there visual evidence of abnormal bone density in the craniofacial area, such as regions that appear unusually dense or less dense than expected?", "Do any soft tissue areas of the face appear thickened, possibly due to excessive fibrous tissue or chronic inflammation?", "Are there signs of abnormal cartilage formation or irregularities in cartilage-containing structures of the face, as might be seen in congenital syndromes?", "Does the cranial size in the image appear increased or decreased, suggesting conditions like premature suture fusion or abnormal brain development?", "Can you detect displacement or malposition of facial structures, possibly resulting from asymmetric bone growth or mass effects?", "Is there evidence of abnormal mineral deposition in the craniofacial bones, such as regions that appear unusually calcified or lacking in mineralization?", "Do the contours or shape of the jaw appear abnormal, indicating possible disruptions in mandibular or maxillary growth?", "Are there areas of the face with abnormal pigmentation patterns, such as patches of lighter or darker skin, that could reflect altered melanocyte function or distribution?"], "properties": ["Does the image show any unusual or atypical features in the craniofacial region?", "Can you identify any irregularities in the structure or symmetry of the face or skull?", "Is there evidence of multiple abnormal formations affecting both the skull and facial bones?", "Does the image contain any signs of combined anomalies involving the head and facial structures?"], "relational": ["Does the image show any unusual features affecting the face, skull, jaw, or eye region?", "Can you identify any abnormalities involving the maxilla, mandible, zygomatic bone, frontal bone, or nasal bone?", "Is there evidence of changes in structures belonging to the skeletal, nervous, or respiratory systems?", "Do you observe alterations in facial features such as the nose, eyes, ears, lips, or cheeks?", "Are there visible differences in tissues like bone, cartilage, muscle, connective tissue, or skin?", "Can you see any irregularities in cranial sutures such as the coronal, sagittal, lambdoid, or metopic suture?", "Is there any indication of malformations or disruptions at the skull base or within the cranial fossae?", "Do you notice any changes in the palate, alveolar ridge, teeth, or oral mucosa?", "Are neighboring structures like the orbit, nasal cavity, paranasal sinuses, or temporomandibular joint affected?", "Can you detect features that might suggest developmental anomalies involving pharyngeal arches, neural crest cells, or the frontonasal prominence?"], "contexual_behavior": [], "functions": ["Does the image show evidence of structural changes that could impair breathing or suggest airway obstruction?", "Can you identify features that might make feeding or swallowing difficult, such as misalignment of oral or pharyngeal structures?", "Is there any indication of altered oral cavity shape or resonance that could interfere with speech development or articulation?", "Does the image reveal abnormalities in the position or structure of the orbits that might lead to visual disturbances or impaired eye movement?", "Are there visible malformations of the external, middle, or inner ear that could be associated with hearing loss?", "Can you see signs of restricted or distorted facial musculature or skeletal structure that might limit facial expression?", "Is there evidence of compromised airway protection mechanisms that could increase the risk of aspiration?", "Does the image suggest disruption of dental alignment or occlusion, such as malocclusion or impaired mastication?", "Are there features indicating abnormal cranial growth patterns, such as an unusual head shape or signs of craniosynostosis?", "Can you identify structural changes that might increase the risk of neurological impairment or neural compression?", "Is there evidence of sinus outflow tract obstruction that could impair sinus drainage or predispose to recurrent infections?", "Does the image show alterations in cranial vault structure that might affect the regulation of intracranial pressure or cerebrospinal fluid flow?"]}, "no_questions": {"contexual_properties": ["Is there a visible abnormality at the base of the cranial bones that could indicate trauma?", "Does the image show any evidence of a fracture involving the base of the skull?", "Can you identify any signs of disruption in the continuity of the bones forming the floor of the cranial cavity?"], "properties": ["Does the image suggest minimal displacement at the site of a skull base fracture, with a gap of less than 2 millimeters?", "Can you estimate the length of a fracture at the skull base, and is it within the range of a few millimeters to several centimeters?", "Is there evidence of a recent traumatic injury in a patient who appears to be between 20 and 40 years old, with findings suggestive of a skull base fracture?"], "relational": ["Can you observe any changes affecting the dura mater, arachnoid mater, or pia mater in the region of the skull base?", "Does the image suggest possible involvement of nerves like the olfactory, optic, oculomotor, facial, vestibulocochlear, glossopharyngeal, vagus, accessory, or hypoglossal nerves?", "Is there a structure in the image that could put the central nervous system, auditory system, or vestibular system at risk?"], "contexual_behavior": ["Can you identify any abnormalities at the base of the cranial bones that could indicate trauma?", "Is there a visible disruption in the continuity of the bones forming the floor of the cranial cavity?", "Does the image reveal any signs suggestive of injury to the lower part of the skull?"], "functions": ["Does the image reveal any features that might indicate an increased risk of central nervous system infection, such as a direct route for bacteria to reach the meninges?", "Are there visual cues that could be associated with functional impairments such as hearing loss, facial paralysis, visual disturbances, or balance problems?", "Does the image suggest the presence of cranial nerve injury, which could manifest as sensory loss or motor impairment?"]}}, "cleft palate": {"yes_questions": {"contexual_properties": ["Does the image show a gap or opening in the palate that appears wider than expected for the patient's age, possibly indicating developmental changes or lack of surgical intervention?", "Is there evidence of a narrowed palatal defect that might suggest successful surgical repair or tissue contraction during healing?", "Can you identify areas of swelling or edema in the palatal region that could be due to acute inflammation, infection, or recent trauma?", "Does the image reveal abnormal tissue growth or nodular changes in the palate, which might result from chronic irritation, repeated surgeries, or neoplastic transformation?", "Are there visible color changes in the palatal tissues, such as pallor, redness, or bruising, that could indicate infection, poor blood supply, or hemorrhage?", "Is there any sign of erythema, swelling, or purulent discharge in the palatal area, which may suggest postoperative infection or recent trauma?", "Can you observe areas of increased fibrosis or scarring in the palate, possibly due to repeated surgical interventions or chronic inflammation?", "Does the image show extensive scar tissue or fibrotic changes in the palate that could be the result of multiple surgeries or delayed healing?", "Are there ulcerated regions in the palatal tissue, which might be caused by trauma, infection, or impaired wound healing?", "Is there evidence of active bleeding or blood accumulation in the palatal area, potentially related to recent surgery, trauma, or a bleeding disorder?", "Can you identify a fistula or abnormal connection in the palate that may have developed after failed surgical repair or ongoing tissue breakdown?", "Does the palatal region appear to be healing slowly, with persistent defects or granulation tissue, possibly due to infection, malnutrition, or systemic disease?", "Is there visible fluid accumulation or edema in the palate that could be associated with infection, inflammation, or postoperative complications?", "Does the palatal defect seem more pronounced or larger than expected for the patient's developmental stage, suggesting progression during a growth spurt or lack of repair?", "Are there observable changes in the tissue composition of the palate, such as areas of scar tissue or altered texture, following surgical repair or chronic inflammation?"], "properties": [], "relational": ["Is there a visible abnormal opening at the roof of the mouth involving the anterior or posterior palatal regions?", "Can you identify a disruption in the continuity of the hard or soft palate?", "Does the image show an abnormal communication between the oral and nasal cavities?", "Are the palatal mucosa, muscle, or underlying bone visibly interrupted in the roof of the mouth?", "Is there evidence of involvement of the alveolar ridge in the palatal region?", "Can you see any discontinuity affecting the palatine processes of the maxilla or the horizontal plates of the palatine bones?", "Is there a defect that extends from the area near the incisive foramen to the region of the uvula?", "Are there visible changes in the upper lip or nasal septum that might be associated with a craniofacial anomaly?", "Does the image suggest possible impact on muscles such as the levator veli palatini, tensor veli palatini, or palatoglossus?", "Can you identify a structural abnormality that could influence the function of the digestive, respiratory, or speech systems?"], "contexual_behavior": [], "functions": ["Does the image show a structure that could impair the separation between the oral and nasal cavities, potentially leading to swallowing difficulties?", "Is there evidence of an anatomical feature that might cause nasal regurgitation during feeding or swallowing?", "Can you identify a condition that would disrupt normal speech production, possibly resulting in hypernasality or articulation errors?", "Does the image include a feature that could make it difficult for an infant to generate suction or coordinate swallowing, potentially leading to poor weight gain?", "Is there a visible abnormality that might increase the risk of recurrent ear infections by affecting Eustachian tube function?", "Can you see a structure that would allow food or air to pass between the oral and nasal cavities during eating or speaking?", "Is there an anatomical finding that could alter airflow, allowing air to escape through the nose during speech and reduce speech intelligibility?", "Does the image reveal a disruption in the attachment or function of facial muscles involved in swallowing, speech, or facial expression?", "Is there a feature that could interfere with the regulation of middle ear pressure by affecting the muscles that open the Eustachian tube?", "Can you identify an abnormality that would reduce the effectiveness of preventing food and liquids from entering the nasal cavity during swallowing?", "Does the image show a condition that could cause excessive nasal resonance or difficulty producing certain consonant sounds in speech?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of a skull without visible sutures separating individual bones?", "Can you identify a cranial vault that lacks the typical segmentation seen in normal skull anatomy?", "Does the image show a cranial structure where the bones appear to be fused into a single unit?"], "relational": ["Is there an object that appears to be formed by the fusion of bones such as the frontal, parietal, occipital, temporal, and sphenoid bones?", "Is there a visible bony structure characterized by the absence of sutures and the presence of a continuous shell?", "Can you identify membranes such as dura mater, arachnoid mater, or pia mater associated with a bony enclosure?"], "contexual_behavior": ["Can you identify a region of the skull that lacks visible sutures between its major components?", "Does the image show a structure where multiple cranial bones appear to be joined together as a single unit?", "Is there evidence of fusion among the bones that typically form the cranial vault?"], "functions": ["Does the image show a compartment that could help regulate intracranial pressure by resisting deformation?", "Can you identify a feature that forms the cranial vault and maintains its shape?", "Is there a structure present that provides encasement and protection for the brain?"]}}, "absence of palpebral fissure": {"yes_questions": {"contexual_properties": ["Does the image show both eyes with fused eyelid margins, suggesting bilateral involvement?", "Is there evidence of eyelid fusion or congenital malformation preventing normal separation of the eyelids?", "Can you identify features consistent with craniofacial syndromes or severe scarring conditions affecting the eyelid region?", "Is there a reduction or complete absence of the visible gap between the eyelids, altering the size of the orbital opening?", "Does the image display changes in facial symmetry due to unilateral eyelid anomalies?", "Are there visible alterations in the contour of the upper and lower eyelids, such as fusion or malformation?", "Can you observe periorbital skin changes, such as scarring or chronic inflammation, near the eyelid area?", "Is there swelling or edema present in the eyelid region, possibly related to trauma or inflammation?", "Do you see abnormal pigmentation around the eyes that could be linked to chronic irritation or post-inflammatory changes?", "Are there signs of thickening or thinning of the eyelid tissues, possibly due to fibrosis or atrophy?"], "properties": ["Does the image show a region near the eye where the skin forms a continuous surface without a visible eyelid opening?", "Is there an area where the normal eyelid gap, typically measuring 8 to 12 millimeters in width, is missing?", "Can you identify a region where the expected eyelid length of 25 to 30 millimeters is not present?", "Does the image contain evidence of fused eyelids or features consistent with ankyloblepharon?", "Is there a skin area near the orbit that matches the color of the surrounding periorbital skin and lacks an eyelid margin?", "Can you see a smooth, uninterrupted skin surface in the region where an eyelid opening would normally be found?", "Is there a region composed only of epidermis, dermis, and connective tissue without any structures typical of eyelids?"], "relational": ["Is there a region in the periorbital area of the face where the normal opening between the eyelids is missing?", "Does the image show an area where the upper and lower eyelids do not form a visible gap?", "Can you observe the absence of the anterior opening to the orbit that typically connects the eyelids to the orbital cavity?", "Is there a lack of visible conjunctiva or cornea in the area normally bordered by the eyelids?", "Does the image depict a disruption in the normal relationship between the eyebrows, eyelids, and canthi?", "Are the tissues adjacent to the eyelids, such as skin or orbicularis oculi muscle, directly continuous without an intervening opening?", "Can you see any abnormality in the periorbital region where the lacrimal apparatus would usually drain into the space between the eyelids?", "Is there an area where the function of the eyelids appears compromised due to the absence of their normal separation?", "Does the image show facial bones such as the maxilla, frontal bone, or zygomatic bone supporting a region without the typical eyelid opening?", "Is there evidence that the visual system is affected by the lack of a normal palpebral fissure in the image?"], "contexual_behavior": ["Is there an eye in the image where the normal opening between the eyelids is missing, potentially preventing tears from draining through the lacrimal system?", "Can you identify a situation where the ocular surface appears unprotected due to the absence of eyelid coverage?", "Does the image show an eye lacking the anatomical structures necessary for normal blinking reflexes?", "Is there evidence of increased corneal dryness, possibly due to an inability of the eyelids to spread the tear film?", "Can you see signs that normal eye lubrication is hindered because tears cannot be distributed across the ocular surface?", "Is there an eye where debris clearance might be compromised due to disrupted blinking and tear flow?", "Does the image suggest a loss of the protective barrier and tear-mediated antimicrobial mechanisms, increasing the risk of eye infections?", "Is there a reduction in the visual field or limited light entry to the retina due to the absence of an eyelid opening?", "Can you observe impaired eyelid closure mechanisms, where the anatomical structures for lid movement and apposition are missing?", "Is there evidence that ocular thermoregulation is altered, such as an inability to maintain corneal temperature through blinking and coverage?", "Does the image show an eye that appears more susceptible to environmental irritants like dust or wind due to lack of protection?", "Is there an indication that the eye remains exposed during sleep because the eyelids cannot close, compromising overnight protection?", "Can you see an eye that cannot regulate light entry in response to bright light due to the absence of a narrowing eyelid aperture?", "Is there evidence of impaired corneal healing, possibly because the ocular surface remains exposed and lacks necessary moisture?", "Does the image suggest that moisture retention on the ocular surface is disrupted due to the inability of the eyelids to prevent tear film evaporation?"], "functions": ["Does the image show a situation where the ocular surface is either completely exposed or covered, indicating an inability to open the eyelids?", "Is there evidence of impaired eye function due to the absence of a protective barrier normally provided by the eyelids?", "Can you identify increased vulnerability of the eye to trauma or environmental hazards because of missing eyelid function?", "Does the image suggest disruption in tear distribution or signs of dryness on the ocular surface?", "Is there an indication that blinking is not possible, resulting in compromised lubrication or maintenance of the eye's surface?", "Can you observe features consistent with severe visual impairment or loss of sight due to the eye being occluded or not exposed?", "Does the image show accumulation of debris on the ocular surface, suggesting impaired clearance mechanisms?", "Is there evidence that the eye cannot regulate light entry due to the eyelids being unable to open or close?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Is there a structure that could be innervated by the vagus nerve or fibers from the celiac plexus?", "Does the image reveal layers such as mucosa, submucosa, muscularis externa, or serosa in a wall of an organ?"], "contexual_behavior": [], "functions": ["Does the image show an area where parietal cells might be present?", "Is there a structure that produces hydrochloric acid to denature proteins and activate digestive enzymes?", "Can you identify an organ that releases hormones like ghrelin to regulate appetite?"]}}}
[ { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bilateral cleft palate" ], "question": "is bilateral cleft palate present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" } ]	["bilateral cleft palate", "face"]	{"bilateral cleft palate": {"yes_questions": {"contexual_properties": ["Does the image show a palatal gap that appears wider than usual, possibly indicating a pre-surgical or growing state?", "Can you observe a deepened separation in the palate that might result from vertical growth of the maxilla during childhood?", "Is there evidence of significant tissue deficiency in the palatal region, suggesting a preoperative or delayed repair condition?", "Do you see abnormal tissue characteristics, such as irregular surfaces, that could be associated with chronic inflammation or infection?", "Is there a palatal defect that appears more pronounced, possibly reflecting a period of rapid craniofacial growth without surgical intervention?", "Can you identify areas of redness or purplish discoloration in the palate, which may indicate infection or inflammation?", "Is there visible scar tissue in the palatal region, suggesting previous surgical repair?", "Do you notice swelling in the palate that could be due to recent surgery or acute infection?", "Is the palatal gap visibly reduced, possibly indicating a successful surgical intervention?", "Can you detect the presence of fluid or exudate in the palatal area, which might be due to infection, inflammation, or fistula formation?", "Are there any ulcerations or open sores in the palate that could result from trauma, infection, or poor oral hygiene?", "Do you see abnormal mucosal texture, such as roughness or irregularity, possibly due to repeated infections, scarring, or failed repairs?", "Is the palatal separation less apparent, potentially reflecting tissue remodeling after surgical repair and aging?", "Can you observe signs of bleeding in the palatal region, which may occur during surgery, trauma, or acute infection?", "Is there a visible fistula or abnormal opening in the palate, possibly indicating a postoperative complication or incomplete healing?"], "properties": ["Is there a structure in the image that shows a gap measuring between 5 and 20 millimeters in width?", "Can you identify a separation extending from the incisive foramen to the uvula, with a length of approximately 20 to 40 millimeters?", "Does the image display a shallow to moderate depression, with a depth between 2 and 8 millimeters, in the palatal region?", "Is there a visible V-shaped or U-shaped gap along the midline of the palate?", "Can you see a midline defect affecting both the hard and soft palate symmetrically?", "Does the image show a structure with a frequency of occurrence in live births between 0.02 and 0.05 percent?", "Is there tissue present that appears pink to reddish, possibly with areas of erythema, in the palatal region?", "Can you identify disrupted mucosa, connective tissue, or exposed bone or cartilage within a palatal gap?", "Does the image reveal a complete separation between the palatal shelves, with no fusion at the midline?", "Is there an area where the palatal tissue thickness is reduced to less than 2 millimeters?", "Can you observe an irregular or uneven surface texture, possibly with ulcerations or granulation tissue, in the palate?", "Is there evidence of bony defects in the palatal region, given that such defects are present in more than 90 percent of similar cases?", "Does the image show involvement of both the hard and soft palate, with the hard palate nearly always affected and the soft palate in most cases?", "Can you see discontinuity or compromised integrity of the mucosa, with exposure of underlying structures in the palate?", "Is the distance between two cleft margins in the palatal region within the range of 5 to 20 millimeters?"], "relational": ["Does the image show a disruption involving both the hard and soft regions forming the roof of the oral cavity?", "Can you identify a gap or separation affecting the midline and lateral aspects of the palatal shelves?", "Is there evidence of interrupted continuity in the maxilla or palatine bones within the oral cavity?", "Does the image reveal separation of the mucosal, muscular, and bony layers of the palate?", "Can you observe a defect indicating failure of fusion between the palatal processes of the maxilla?", "Is there a visible abnormality that could impact muscles such as the levator veli palatini or tensor veli palatini?", "Does the image show a structure adjacent to the nasal septum, upper lip, or lateral nasal wall that appears disrupted?", "Are the anatomical boundaries from the alveolar ridge to the uvula and lateral palatal shelves visibly altered?", "Can you detect additional anomalies such as a cleft in the upper lip, irregular dental development, or nasal deformities?", "Is there an abnormal opening between the oral and nasal cavities that could affect speech or feeding?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structural defect that could allow food or liquids to pass from the mouth into the nasal cavity, potentially leading to nasal regurgitation?", "Is there a visible abnormal communication between the oral and nasal spaces that might disrupt normal swallowing or oropharyngeal coordination?", "Can you identify a feature that could prevent proper closure of the velopharyngeal port, possibly resulting in hypernasal speech or articulation difficulties?", "Does the image suggest a condition that would make it difficult for an infant to create suction during feeding, potentially leading to poor intake or prolonged feeding times?", "Is there a structural abnormality that could compromise airway protection during eating or drinking, increasing the risk of aspiration or choking?", "Can you see an oronasal fistula or palatal defect that disrupts the normal separation between the oral and nasal cavities?", "Does the image show a feature that might alter nasal airflow or increase the likelihood of airway obstruction, possibly causing breathing difficulties?", "Is there evidence of a defect that could reduce the ability to generate intraoral pressure, affecting effective sucking, swallowing, or speech sound production?", "Can you identify a structural issue that might impair Eustachian tube function, increasing the risk of recurrent ear infections or middle ear effusion?", "Does the image suggest disturbances in facial growth or dental alignment, such as maxillary deficiency or malocclusion?", "Is there any indication that the individual may have developed compensatory mechanisms, such as atypical speech articulation or altered swallowing patterns, to adapt to a structural defect in the palate?"]}, "no_questions": {"contexual_properties": ["Does the image show an increased number of small, bright spots that could be associated with ductal carcinoma in situ or a benign proliferative process?", "Can you identify bright spots associated with areas of tissue distortion that could be due to invasive carcinoma or postsurgical changes?", "Are there regions with denser bright spots that could be related to metabolic disorders or chronic inflammation?"], "properties": ["Can you see one to three distinct clusters of high-density, radiopaque spots?", "Can you identify round, punctate, or irregularly shaped radiopaque foci in the image?", "Does the image show multiple bright, highly radiopaque spots measuring less than 1 millimeter in size?"], "relational": ["Does the image appear to be acquired using digital mammography or tomosynthesis, as opposed to ultrasound or MRI?", "Are there dense regions that appear to be connected to ductal walls, the stromal matrix, or adjacent lobules within the breast tissue?", "Can you identify any bright spots in regions such as the upper outer quadrant or subareolar area of the breast?"], "contexual_behavior": ["Is there an indication that tomosynthesis was used, such as multiple sectional images, which could reduce tissue overlap and enhance the conspicuity of small lesions?", "Can you observe tissue changes or fibrosis that might be consistent with prior radiation therapy and could obscure small bright deposits?", "Does the image appear to be from a younger individual, with denser tissue that could make the identification of small calcified areas less reliable?"], "functions": ["Are there patterns present that could contribute to assessing an individual's risk for developing breast cancer?", "Is there evidence of patterns or distributions that could help in recognizing malignant lesions?", "Can you observe any changes in the number, size, or appearance of certain features that would be relevant for monitoring disease progression?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a pathological process affecting the respiratory system?", "Is there a visible mass or abnormality in the peripheral lung fields or lower lobes?", "Does the image show any signs of bronchial obstruction or airway compression?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a process that could lead to impaired respiratory function or reduced oxygenation?", "Does the image reveal a reduction in alveolar surface area or signs of ventilation-perfusion mismatch?", "Is there evidence of abnormal tissue that might facilitate lymphatic or hematogenous spread to other organs?"]}}}
[ { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basilar skull fracture" ], "question": "is basilar skull fracture present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" } ]	["bone", "calvarium", "basilar skull fracture"]	{"bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see any cells whose cytoplasm contains both granules and glycogen?", "Does the image include cells that might contain enzymes such as myeloperoxidase or elastase?", "Are there cells whose average size or volume could be estimated at around 300 to 400 femtoliters?"], "relational": ["Does the image include structures produced in the bone marrow?", "Does the image show a component of the immune system?", "Is there evidence of cells located within inflamed or infected tissue?"], "contexual_behavior": [], "functions": ["Is there evidence of degranulation, such as the release of antimicrobial peptides or proteases?", "Do you observe cells that could be producing reactive oxygen species for microbial killing?", "Does the image contain cells that perform phagocytosis and lysosomal degradation of pathogens or debris?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Can you identify any masses that appear denser, potentially due to cell proliferation or fibrosis?", "Are there changes in the texture of any masses, which could be due to alterations in cellular composition, fibrosis, or necrosis?", "Are there fewer masses present, which might suggest successful treatment or lesion resolution?"], "properties": ["Is there an area that shows only mild to moderate contrast with the surrounding tissue?", "Can you identify a region with an irregular or non-spherical shape?", "Can you find an area with a heterogeneous or inhomogeneous internal texture?"], "relational": ["Can you identify a mass-like feature that appears within the breast parenchyma or mammary glands?", "Can you identify a mass-like area defined by anatomical boundaries such as the skin, pectoral muscle, or chest wall?", "Is there an abnormality that appears within or adjacent to scattered fibroglandular tissue?"], "contexual_behavior": ["Does the image contain a mass that is less distinguishable, potentially as a result of chemotherapy-induced changes in tissue contrast?", "Is there an area where a lesion appears more detectable, potentially due to transient changes in breast tissue during the luteal phase of the menstrual cycle?", "Is there a lesion whose clinical significance appears reduced, possibly following a benign biopsy result?"], "functions": ["Is there visual evidence of increased cellular density or abnormal tissue organization?", "Is there any indication of altered vascularization or physiological changes in the breast tissue?", "Are there features suggesting local tissue remodeling, such as increased stromal reaction or fibrosis?"]}}, "basilar skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a fracture involving the base of the skull, particularly in bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Is there a fracture line at the cranial base that appears less than a few millimeters wide?", "Does the image reveal a break limited to the thickness of the cranial base bones, typically only a few millimeters deep?", "Can you see a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Is there a lucent line traversing the base of the skull visible on the image?", "Does the image show an air-fluid level or evidence of pneumocephalus near the base of the skull?", "Can you identify any signs of cerebrospinal fluid leakage in association with a skull base fracture?", "Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Does the image suggest a unilateral fracture at the base of the skull, rather than a bilateral one?", "Is the temporal bone involved in the observed skull base fracture?", "Can you estimate whether the displacement of the fracture at the skull base is minimal, less than 2 millimeters?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?", "Are there air-fluid levels present near the base of the skull, as seen in about 20% to 30% of such fractures?", "On CT imaging, is there a hypodense (lucent) line at the base of the skull relative to the surrounding bone?", "Can you observe bruising patterns such as blue or purple discoloration behind the ear or around the eyes, which may change to yellow-green as they resolve?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Can you identify abnormalities in the anterior, middle, or posterior cranial fossae?", "Is there any indication of injury near the course of cranial nerves like the olfactory, optic, or facial nerves?", "Does the image reveal changes involving foramina such as the foramen magnum or cribriform plate?", "Are there visible alterations adjacent to the inner ear, nasal cavity, or orbit?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?", "Is there evidence of communication between the cranial cavity and spaces such as the subarachnoid space or paranasal sinuses?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Are there signs of disruption in sinuses such as the sphenoid or ethmoid sinus?", "Can you identify exposure or compromise of anatomical pathways like cerebrospinal fluid pathways or the auditory canal?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a disruption in the structural integrity of the skull base that could compromise brain protection?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Can you identify features suggesting a breach between the nasal cavity and cranial cavity, such as a defect in the cribriform plate?", "Does the image reveal any signs that could explain cranial nerve deficits, such as those affecting facial movement, hearing, vision, or swallowing?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?", "Can you see any indications that might increase the risk of infection entering the central nervous system, such as a direct pathway for pathogens?", "Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Are there features present that could facilitate the development of a cerebrospinal fluid leak due to openings in the dura mater or bone?", "Is there any sign of functional impairment, such as altered consciousness, seizures, or focal neurological deficits, that could be explained by a structural abnormality at the skull base?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you find a region with marked cellular crowding, where cells are closely packed together?", "Is there a section where the epithelial layer is thicker than normal, with several cell layers visible?", "Is there an area where the cytoplasm of cells is moderate in amount and may show a slightly basophilic (bluish) appearance?"], "relational": ["Does the image contain cells with features such as increased nuclear-to-cytoplasmic ratio or nuclear atypia?", "Is there evidence of cellular disorganization or loss of polarity in the epithelial or glandular layers?", "Does the image show areas with architectural complexity or cellular pleomorphism compared to surrounding parenchyma?"], "contexual_behavior": [], "functions": ["Does the image suggest disruption of cell cycle control or reduced apoptosis in a particular area?", "Does the image show alterations in cellular signaling pathways related to growth, differentiation, or apoptosis?", "Is there a lesion that could serve as a precursor to neoplastic progression?"]}}}
[ { "answer": "yes", "extracted_concepts": [], "question": "does this image show good close-up?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "basal skull fracture", "extracted_concepts": [ "basal skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basal skull fracture" ], "question": "is basal skull fracture present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "basal skull fracture", "extracted_concepts": [ "basal skull fracture" ], "question": "what is present?" } ]	["basal skull fracture", "bone", "calvarium"]	{"basal skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Is there evidence of a fracture involving the base of the skull, particularly affecting bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a fracture line at the skull base that measures from a few millimeters to several centimeters in length?", "Does the image show a fracture at the skull base with a width generally less than 2 millimeters?", "Is there a fracture whose depth appears limited to the thickness of the skull base, typically a few millimeters?", "Can you observe a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Does the imaging reveal a lucent line traversing the skull base, possibly accompanied by air-fluid levels or bone fragments?", "Is there any indication of cerebrospinal fluid leakage in association with a fracture at the skull base?", "Can you see a fracture at the skull base with minimal bone displacement, often less than 1 millimeter?", "Is there bruising near the base of the skull that appears blue or purple, or is transitioning to yellow-green?", "Does the image show air-fluid levels within the paranasal sinuses, which could be present in up to 30% of such cases?", "Is there an area at the skull base where bone density appears reduced compared to surrounding normal bone on CT imaging?", "Can you identify signs that suggest bone healing at the skull base, which typically occurs over 6 to 12 weeks?", "Does the thickness of the skull base at the site of a fracture fall within the range of 3 to 10 millimeters?", "Is there evidence of fluid discharge from the ear canal (otorrhea) in association with a skull base injury?", "Can you observe any signs of nasal fluid leakage (rhinorrhea) that might be related to a fracture at the base of the skull?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Is there any abnormality visible in the anterior, middle, or posterior cranial fossae?", "Can you identify changes near the course of cranial nerves like the olfactory, optic, oculomotor, facial, or vestibulocochlear nerves?", "Is there a visible irregularity involving foramina such as the foramen magnum, jugular foramen, foramen ovale, foramen spinosum, or cribriform plate?", "Are the adjacent meningeal layers, including dura mater, arachnoid mater, or pia mater, affected in the image?", "Can you see any compromise to vascular structures like the internal carotid artery, vertebral artery, or venous sinuses?", "Is there involvement of cavities or air spaces such as the paranasal sinuses, middle ear cavity, or mastoid air cells?", "Does the image reveal disruption of anatomical barriers separating the base of the skull from the brain, such as the dura mater or cranial fossae?", "Are there any abnormalities near central nervous system structures like the brainstem, cerebellum, or cranial nerve nuclei?", "Can you detect structural changes in the orbit, nasal cavity, auditory canal, or mastoid process?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structural compromise at the base of the skull that could reduce protection for the brain?", "Is there any indication of a breach in the barrier between the brain and the external environment, such as a meningeal disruption?", "Can you identify signs that suggest a cerebrospinal fluid leak, such as fluid accumulation near the nasal or ear cavities?", "Is there visual evidence of a dural tear or rhinorrhea that might indicate disrupted cerebrospinal fluid dynamics?", "Does the image reveal any injury to cranial nerves at the skull base, potentially resulting in facial paralysis or diplopia?", "Are there features suggesting damage to the temporal bone or vestibulocochlear nerve, such as findings consistent with hearing loss or balance disturbance?", "Can you see any abnormalities that might increase the risk of central nervous system infection, such as direct communication between the nasal or ear cavities and intracranial space?", "Is there evidence of a hematoma or other signs of direct trauma to neural tissue that could contribute to neurological deficits?", "Does the image show possible injury to vascular structures at the skull base, such as the carotid artery or venous sinuses, that could lead to hemorrhage or thrombosis?", "Are there findings that suggest altered intracranial pressure regulation, such as indications of CSF leakage or intracranial bleeding?"]}, "no_questions": {"contexual_properties": ["Can you see regions with increased redness or pallor, suggesting changes in blood flow or oxygenation?", "Are there visible changes in the vascular pattern, such as prominent or dilated blood vessels?", "Are there any masses, nodules, or irregular tissue formations visible that might indicate abnormal growths or lesions?"], "properties": [], "relational": ["Does the image contain a magnified view of a specific anatomical structure?", "Does the image display layers like the epidermis, dermis, subcutaneous tissue, or mucosa in a focused region?", "Can you see anatomical landmarks such as fissures, sulci, glands, or blood vessels in a detailed view?"], "contexual_behavior": ["Does the image hinder the assessment of functional movement or joint interactions due to a limited focus on a small area?", "Is the effectiveness of surgical navigation or spatial orientation reduced because anatomical landmarks are obscured by the perspective shown?", "Does the view in the image make it difficult to assess overall organ function because of a limited field of view?"], "functions": []}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see any involvement of anatomical landmarks such as the epiphysis, diaphysis, metaphysis, or articular surface?", "Can you detect abnormalities in bones that are weight-bearing or appear osteoporotic?", "Is there a visible alteration in regions surrounded by muscle tissue, connective tissue, blood vessels, or skin?"], "contexual_behavior": [], "functions": ["Can you identify features consistent with immobilization, such as maintained bone alignment or restricted movement at the injury site?", "Is there visual evidence of biological processes such as inflammation or callus formation at a site of bone injury?", "Does the image suggest the influence of regulatory mechanisms, such as growth factors or cytokines, in the healing process?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Is there a tubular structure in the image that appears to be attached to an ovary located on the opposite side?", "Can you identify a tube-like feature that is adherent to an adjacent ovarian structure across from it?", "Does the image show a tube that is in close contact with an ovary on the other side of the field?"], "properties": ["Is there a tubular structure in the image that appears to be attached to an ovary located on the opposite side?", "Does the image show a tube in close association with an ovary that is positioned on the other side of the body or field of view?", "Can you identify a tube-like feature that is visually adherent to an adjacent ovarian structure on the contralateral side?"], "relational": ["Is there a tube in the image that could receive blood supply from the ovarian or uterine arteries?", "Is there evidence of fimbrial or pathological adhesions between a tubular structure and an adjacent ovary?", "Does the image show a structure that is part of the female reproductive system and is physically attached to an ovary?"], "contexual_behavior": ["Can you identify a tube adjacent to an ovary that appears distorted or immobile, suggesting possible tubal dysfunction?", "Does the image show a tube with features suggesting increased susceptibility to infection, such as mucosal barrier disruption or impaired drainage?", "Is there evidence of a tubular structure whose movement is restricted by adhesions to a nearby ovary, potentially impairing ovum transport?"], "functions": ["Is there a tube present that supplies nutrients and maintains a microenvironment for an embryo in transit?", "Does the image show a structure adjacent to an ovary that is involved in transporting eggs?", "Can you identify a feature that could maintain an optimal environment for fertilization, such as by regulating pH or producing secretions?"]}}}
[ { "answer": "distended hydropic villi and proliferation of the chorionic epithelium", "extracted_concepts": [ "distended hydropic villi", "microscopic image", "proliferation of the chorionic epithelium" ], "question": "what are evident in this microscopic image?" }, { "answer": "yes", "extracted_concepts": [ "distended hydropic villi", "microscopic image", "chorionic epithelium", "proliferation of the chorionic epithelium" ], "question": "are distended hydropic villi and proliferation of the chorionic epithelium evident in this microscopic image?" } ]	["distended hydropic villi", "microscopic image", "chorionic epithelium", "proliferation of the chorionic epithelium"]	{"distended hydropic villi": {"yes_questions": {"contexual_properties": ["Does the image show structures that have increased in size, as might be seen in gestational trophoblastic disease?", "Can you identify areas where there is excessive fluid accumulation within the villous stroma, indicating hydropic change?", "Is there evidence of increased fluid content in structures associated with abnormal placental development or molar pregnancy?", "Do any regions appear more translucent, possibly due to stromal edema and thinning of tissue?", "Are there edematous changes in placental tissue that could suggest a gestational trophoblastic disorder?", "Can you see any loss of normal structure in villous tissue, which might result from extensive hydropic degeneration?", "Is there an area where increased proliferation of trophoblastic cells or loss of stromal cell integrity is visible?", "Do any structures appear more fragile or have thinned walls, possibly due to marked edema?", "Are there abnormal surface features such as irregular contours or excessive cellular covering, as seen in molar pregnancies?", "Can you observe changes in shape or morphology of villous tissue due to swelling and fluid accumulation?", "Is there evidence of increased stromal cell proliferation, particularly in association with partial moles?", "Do any villous structures show abnormal or decreased blood vessel formation, indicating altered vascularity?", "Are there more numerous villous structures in the placental tissue, as might occur in molar pregnancy?", "Can you identify areas with increased cellular covering, consistent with excessive trophoblastic proliferation in complete moles?", "Is there abnormal accumulation of extracellular matrix within villous tissue, suggesting pathological edema?"], "properties": ["Does the image show any structures that are rounded or balloon-like in shape?", "Can you identify objects that appear translucent, pale, or whitish in color?", "Are there any features measuring approximately 2 to 4 millimeters in diameter?", "Do you see any structures with a markedly enlarged volume compared to typical villi?", "Is there evidence of objects with a soft, cystic, or spongy texture?", "Can you find features that appear to have a high water content or are edematous?", "Are there structures with a central region containing scattered cells surrounded by an outer layer?", "Do any objects display a thin or attenuated outer layer?", "Is there a visible stroma that looks myxoid, edematous, and has low cellularity?", "Can you identify features with few nuclei or sparse stromal cell nuclei?", "Are there structures exhibiting fluid-filled spaces within their central region?", "Do any objects appear less dense due to expansion and increased fluid content?", "Is there evidence of marked edema or significant fluid accumulation within certain structures?", "Can you see features with an increased surface area relative to normal villi due to swelling?"], "relational": ["Does the image show any abnormal structures within the placenta?", "Can you identify tissue that is part of the villous or chorionic region of the placenta?", "Is there evidence of structures surrounded by trophoblastic layers and intervillous space?", "Are there visible features that contain cell types such as cytotrophoblasts or syncytiotrophoblasts?", "Can you see villous tissue with stromal cells present?", "Is there a structure that appears to contain fetal capillaries or an edematous stroma?", "Does the image include villi that differ from normal chorionic villi or avascular villi?", "Are there any regions adjacent to the amniotic or chorionic membranes that appear abnormal?", "Can you identify areas where maternal blood in the intervillous space interacts with fetal vessels within villi?"], "contexual_behavior": [], "functions": ["Does the image show placental structures that appear abnormal and do not perform typical functions during pregnancy?", "Can you identify areas where nutrient and gas exchange between mother and fetus might be impaired due to edematous tissue?", "Is there evidence of abnormal placental development, such as features associated with molar pregnancy?", "Does the image contain structures with excessive fluid accumulation in the villous stroma, suggesting edema?", "Can you see signs that might indicate altered hormone production or abnormal trophoblastic activity in the placenta?", "Is there a reduction in effective surface area within the placental tissue that could impair its function?", "Does the image suggest a disruption in fluid balance within the placenta?", "Are there features that could contribute to fetal growth restriction or developmental impairment by limiting oxygen and nutrient delivery?", "Can you observe any disruption in the regulation of maternal-fetal circulation that might increase the risk of pregnancy complications?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure whose estimated weight could fall between 10 and 200 grams?", "Is there a structure that likely expresses estrogen and progesterone receptors?", "Does the structure appear to have a moderate to high cellular density compared to adjacent cervical tissue?"], "relational": ["Does the image contain a mass composed of smooth muscle and connective tissue?", "Does the image show a mass associated with the female reproductive system?", "Is there a fibroid specifically located in the cervical portion of the uterus?"], "contexual_behavior": [], "functions": ["Is there evidence of a mass distorting the anatomy of the uterus?", "Is there a structure present that might interfere with sperm transport or embryo implantation, potentially reducing fertility?", "Is there a feature that might hinder cervical dilation during labor, increasing the risk of obstructed labor?"]}}, "microscopic image": {"yes_questions": {"contexual_properties": [], "properties": ["Can you determine if the image has a high number of pixels per unit area, indicating fine detail?", "Is there evidence of a scale bar that could help estimate the magnification level, such as 10x or 100x?", "Does the image display color information that suggests a specific color depth, like 8-bit or 24-bit?", "Can you infer the physical size represented by each pixel, such as micrometers per pixel?", "Is there any indication of the file format, such as visible compression artifacts typical of JPEG or the clarity associated with TIFF or PNG?", "Can you estimate the horizontal dimension of the image in pixels, for example, whether it is closer to 1024 or 2048 pixels wide?", "Does the vertical dimension of the image appear to match common values like 768 or 1536 pixels?", "Is it possible to deduce the number of bits used for each pixel based on the image's color richness or grayscale levels?", "Can you assess whether the difference in luminance or color between objects and background is high, indicating a strong contrast ratio?", "Does the overall light intensity suggest a particular brightness level, such as a high mean pixel intensity?", "Is there a visible reference bar that provides a measurement scale in micrometers or nanometers?", "Can you estimate the aspect ratio of the image, such as whether it is closer to 4:3 or 16:9?", "Does the image allow you to infer the spatial resolution, such as 0.5 \u03bcm/pixel or 1 \u03bcm/pixel?", "Is the background color predominantly white, black, or light gray?", "Can you estimate whether the file size would be in the kilobyte, megabyte, or gigabyte range based on the image's resolution and apparent format?"], "relational": ["Does the image display structures that could be cells or tissues?", "Can you identify features that resemble microvasculature?", "Is there evidence of epithelial, connective, muscle, or nervous tissue present?", "Can you see cellular components such as nuclei or cytoplasm?", "Does the image reveal details that might belong to the nervous, digestive, respiratory, or cardiovascular systems?", "Is there any indication that the visualized material comes from a histological section or tissue slice?", "Can you identify regions that could correspond to skin, liver, kidney, or lung?", "Are there visual cues suggesting the use of stains like hematoxylin and eosin, PAS, or immunohistochemistry?", "Does the image appear to be derived from a tissue sample, biopsy, or organ section?", "Can you observe structures at the organ, tissue, cell, or subcellular level?", "Is there evidence of subcellular features such as mitochondria or nucleoli?"], "contexual_behavior": ["Does the image show evidence of inadequate sample preparation, such as loss of cellular detail or the presence of artifacts?", "Can you identify signs of poor fixation, incomplete staining, or sample degradation affecting the diagnostic quality of the image?", "Is there visual evidence of altered cellular activity, such as atypical cell shapes or areas of necrosis?", "Does the image display features consistent with inflammation, like increased cellularity or immune cell infiltration?", "Are there regions where specific staining techniques have enhanced contrast or highlighted particular cellular components?", "Can you observe the effects of histochemical stains, immunohistochemistry, or fluorescent labeling in the image?", "Is there a loss of normal tissue organization, such as disorganization or fibrosis, that might indicate a disease process?", "Does the image reveal structural disruption, such as tumor infiltration or breakdown of tissue architecture?", "Are there morphological changes in cells that could be attributed to infection, such as swelling, infiltration, or inclusion bodies?", "Can you detect reduced staining intensity or diminished enzyme activity that might suggest hypoxic conditions?", "Is there evidence of decreased metabolic activity, such as pale or poorly stained regions, in the image?", "Does the image highlight the accumulation or activation of immune cells, suggesting an inflammatory response?", "Are mitotic figures difficult to identify, possibly due to treatment effects or fixation artifacts?", "Can you see chromatin condensation or other changes that might obscure mitotic structures in treated samples?", "Is there visual evidence of cell death, vacuolization, or organelle damage that could result from toxin exposure?", "Does the image display increased cell proliferation or migration, indicating tissue regeneration after injury?", "Are there signs of matrix remodeling or enhanced cellular interactions consistent with regenerative processes?"], "functions": ["Does the image provide visual information that could be used to identify disease states based on cellular or tissue features?", "Can you detect any abnormalities in cell size, shape, or structure that might indicate pathology?", "Is there evidence in the image that could be used to monitor changes in tissue or cellular characteristics over time?", "Does the image reveal the presence of bacteria, viruses, fungi, or parasites within the sample?", "Can you assess the detailed architecture and cellular composition of tissue in the image?", "Is it possible to evaluate the shapes, sizes, and distributions of red and white blood cells in this image?", "Does the image display pathological features that could influence therapeutic decisions, such as tumor grade or infection type?", "Can you identify signs of malignancy, inflammation, or other pathological changes that would be relevant for biopsy evaluation?", "Does the image allow for the visualization of cellular processes such as cell division or signaling at high resolution?", "Is there enough morphological detail in the image to classify microorganisms based on their distinguishing traits?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a feature adjacent to the vessel lumen or tunica media?", "Does the image contain an area with cells such as macrophages or foam cells?", "Can you see a disruption in the structure of an arterial wall?"], "contexual_behavior": [], "functions": ["Is there a region where the fibrous cap of an arterial wall appears thinned or weakened, increasing the risk of rupture?", "Is there evidence of vessel wall erosion or rupture that might lead to hemorrhage or thrombosis?", "Is there an area where the vessel wall appears disrupted, possibly exposing material that could promote blood clot formation?"]}}, "chorionic epithelium": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a tissue layer with a thickness between 10 and 30 micrometers?", "Can you identify a structure composed mainly of trophoblast cells, such as cytotrophoblasts or syncytiotrophoblasts?", "Is there a region where the cells are approximately 10 to 20 micrometers in diameter?", "Does the image contain cells that appear polygonal or cuboidal in shape?", "Can you see a tissue that appears pale eosinophilic to pinkish under the microscope?", "Is there a layer that consists of only one or two cell layers in thickness?", "Does the image show a structure likely to express proteins such as cytokeratins, human chorionic gonadotropin, or placental lactogen?", "Can you identify a tissue with a high water content, around 70 to 80 percent by weight?", "Is there a region where the lipid content appears to be less than 5 percent of the tissue weight?", "Does the image show a tissue with moderate glycogen content, serving as an energy reserve for trophoblast cells?", "Is there evidence of a low mitotic index, with less than 5 percent of cells undergoing division?", "Can you see a region with a cell density of approximately 1 to 2 \u00d7 10^5 cells per square millimeter?", "Does the tissue appear to have a pH close to physiological levels, around 7.2 to 7.4?", "Is there a surface area that could reach several square meters in a mature placenta?", "At the ultrastructural level, can you identify features such as microvilli, abundant mitochondria, or tight junctions between cells?"], "relational": ["Does the image show a layer that forms part of the fetal membranes?", "Is there a structure present that is adjacent to both the trophoblast externally and the extraembryonic mesoderm internally?", "Can you identify a region containing cell types such as cytotrophoblasts or syncytiotrophoblasts?", "Does the image include a component associated with both the amnion and the allantois?", "Is there a structure interacting with maternal tissues like the decidua basalis of the endometrium?", "Can you see a layer participating in the development of chorionic villi and contributing to the placenta?", "Does the image contain a structure that supports the fetal side of the placenta?", "Is there a region derived from embryonic tissues originating from the trophoblast?", "Can you identify a boundary between the amniotic membrane and the extraembryonic mesoderm?", "Does the image show a layer located within the chorionic membrane or the fetal portion of the placenta?"], "contexual_behavior": [], "functions": ["Does the image show a structure that mediates both nutrient and gas exchange between maternal and fetal circulations?", "Can you identify a layer that is responsible for selective transport of essential molecules from the mother to the fetus?", "Is there a visible interface where oxygen diffusion to the fetus and removal of carbon dioxide to the mother could occur?", "Does the image contain a region likely involved in the synthesis and secretion of hormones such as human chorionic gonadotropin?", "Can you see a barrier that might protect the fetus from maternal immune responses by modulating immune cell activity?", "Is there evidence of a structure that regulates passage of substances to the fetus through selective permeability or active transport?", "Does the image include a component that facilitates the transfer of fetal metabolic waste products into the maternal circulation?", "Can you identify a layer that restricts harmful substances and pathogens while allowing essential exchanges between mother and fetus?", "Is there a structure that supports fetal growth by ensuring a balanced supply of nutrients, gases, and hormones?", "Does the image show a region involved in promoting adhesion and invasion during the establishment of the maternal-fetal interface at implantation?"]}, "no_questions": {"contexual_properties": ["Does the image suggest loss of volume, possibly due to menopause, significant weight loss, aging, or surgical intervention?", "Are there visible calcifications that could be associated with aging, benign fibrocystic changes, or ductal carcinoma in situ?", "Are there areas of skin ulceration that may be due to advanced malignancy, chronic infection, or trauma?"], "properties": ["Can you identify a structure whose volume could be estimated between 200 and 500 milliliters?", "Can you identify an object whose average weight might be between 200 and 400 grams?", "Can you see a region where tissue density could be estimated between 0.9 and 1.1 grams per cubic centimeter?"], "relational": ["Does the image show ducts that could transport secretions to the surface?", "Does the image show a structure that is part of both the integumentary and reproductive systems?", "Can you identify supporting structures such as Cooper\u2019s ligaments or pectoral fascia?"], "contexual_behavior": ["Is there evidence of impaired tissue repair that could result from poor vascularization or chronic inflammation?", "Can you identify a tissue that may reduce its secretory function due to decreased estrogen and progesterone, as seen in menopause?", "Is there a structure that might have reduced antimicrobial activity in disease states such as mastitis?"], "functions": ["Does the image show a structure involved in providing nourishment to infants?", "Is there an object whose function is regulated by hormones such as prolactin or oxytocin?", "Can you see evidence of a system that supports passive immunity in infants?"]}}, "proliferation of the chorionic epithelium": {"yes_questions": {"contexual_properties": ["Does the image show evidence of increased cellular growth in structures associated with early pregnancy or gestational trophoblastic disease?", "Can you identify areas where cellular proliferation appears reduced, as might be seen in late pregnancy or placental insufficiency?", "Is there a region displaying abnormal growth patterns suggestive of hydatidiform mole or choriocarcinoma?", "Does the image reveal thickened tissue layers that could indicate excessive cellular replication, as in molar pregnancies?", "Are there visible structural changes consistent with pathological remodeling, such as those found in trophoblastic tumors?", "Can you observe cellular atypia or irregular cell shapes that might be present in neoplastic conditions like choriocarcinoma?", "Is there evidence of excessive tissue growth, possibly indicating a gestational trophoblastic neoplasm or complete mole?", "Do you see an increased number of mitotic figures within rapidly expanding lesions of trophoblastic origin?", "Is there a mass formation visible that could correspond to choriocarcinoma or an invasive mole?", "Are there regions where tissue proliferation appears insufficient, as might occur in placental insufficiency or fetal growth restriction?", "Can you detect changes in cellular composition or abnormal differentiation within areas affected by trophoblastic disease?", "Does the image show signs of edema or swelling, such as hydropic changes associated with molar pregnancies?", "Are there areas where tissue density appears altered, potentially reflecting hyperplasia or neoplastic transformation?", "Is there evidence of abnormal layering or disorganized cellular architecture, as seen in trophoblastic tumors?", "Do you observe regions of increased cellularity that could indicate hyperplastic lesions or gestational trophoblastic disease?"], "properties": ["Does the image show evidence of increased cell numbers in the outermost fetal membrane?", "Can you identify regions where the surface layer of the chorion appears thicker than usual?", "Is there a visible indication of active cell division in the epithelial covering of the chorion?", "Does the image contain any abnormal growth or expansion of the chorionic surface layer?"], "relational": ["Does the image show a region that forms the outermost fetal layer of the placenta?", "Can you identify a tissue that is part of the chorion within the fetal membranes?", "Is there evidence of a structure adjacent to both the trophoblast and extraembryonic mesoderm?", "Does the image contain layers such as cytotrophoblast and syncytiotrophoblast?", "Can you see a region composed of cytotrophoblasts and syncytiotrophoblasts?", "Is there a structure that is separated from the amniotic membrane by the extraembryonic mesoderm?", "Does the image show a tissue that interacts with the decidua basalis or maternal blood spaces?", "Can you identify a region contributing to the structure of the placenta?", "Is there a visible connection to embryonic structures such as the embryonic disc or connecting stalk?", "Does the image include vascular features like chorionic villi or fetal capillaries?", "Can you see a fetal membrane that is related to the amnion, yolk sac, or allantois?"], "contexual_behavior": ["Does the image show evidence of increased cellular activity in the outermost fetal membrane?", "Can you identify regions where the epithelial layer of the chorion appears thicker or denser than usual?", "Is there a visible indication of abnormal growth or expansion in the tissue covering the fetal side of the placenta?", "Does the image contain areas suggestive of enhanced cell division within the chorionic surface?"], "functions": ["Does the image show evidence of increased surface area in a structure that supports fetal-maternal interactions?", "Can you identify features consistent with the formation or branching of villi within the placenta?", "Is there a region where efficient nutrient or gas exchange between mother and fetus is likely occurring due to expanded placental surface?", "Does the image suggest an increased number of cells involved in nutrient transfer between maternal and fetal compartments?", "Can you observe areas that may correspond to hormone-secreting trophoblasts, potentially indicating active hormone regulation during pregnancy?", "Is there a continuous epithelial layer visible that could serve as a selective barrier regulating molecular passage between maternal and fetal tissues?", "Does the image provide visual cues of active cell proliferation, differentiation, or tissue remodeling within placental structures?", "Can you see evidence of cellular expansion contributing to the outgrowth or development of villous structures?", "Is there a robust barrier apparent that might limit immune cell infiltration and help protect the fetus from maternal immune responses?", "Does the image display features that support the maintenance of pregnancy, such as placental growth or sustained maternal-fetal exchange?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure that might contain proteins at concentrations similar to plasma ultrafiltrate, about 1\u20133 g/dL?", "Is there an area that could be lined by a single layer of mesothelial cells?", "Does the image show a surface that likely has low lipid content, primarily composed of membrane phospholipids?"], "relational": ["Is there a visible layer formed by mesothelium or connective tissue?", "Can you identify a surface that covers the stomach, intestines, lungs, or heart?", "Is there a structure surrounding the heart that could be a serosal membrane?"], "contexual_behavior": ["Can you observe features suggesting increased permeability of a mesothelial layer, possibly due to cytokine activity during inflammation?", "Is there visual evidence of barrier dysfunction, such as loss of separation between tissues, possibly due to severe inflammation or injury?", "Is there any indication of reduced anti-inflammatory function, such as persistent irritation or chronic disease affecting tissue appearance?"], "functions": ["Can you identify a surface that appears to provide a lubricated interface enabling smooth movement of organs?", "Can you see a surface that might shield internal organs from mechanical injury or infection?", "Is there evidence of a structure involved in fluid secretion or absorption within the body cavity?"]}}}
[ { "answer": "fixed tissue dissected eyes", "extracted_concepts": [ "dissected eyes", "fixed tissue" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "dissected eyes", "fixed tissue" ], "question": "does this image show fixed tissue dissected eyes?" }, { "answer": "conjoined twins cephalothoracopagus janiceps", "extracted_concepts": [ "conjoined twins", "cephalothoracopagus", "janiceps" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "conjoined twins", "cephalothoracopagus", "janiceps" ], "question": "is conjoined twins cephalothoracopagus janiceps present?" }, { "answer": "fixed tissue", "extracted_concepts": [ "dissected eyes?", "fixed tissue" ], "question": "what dissected eyes?" }, { "answer": "eyes", "extracted_concepts": [ "eyes", "fixed tissue" ], "question": "what is fixed tissue dissected?" }, { "answer": "conjoined twins cephalothoracopagus janiceps", "extracted_concepts": [ "conjoined twins", "cephalothoracopagus janiceps" ], "question": "what is present?" } ]	["dissected eyes?", "janiceps", "eyes", "cephalothoracopagus janiceps", "cephalothoracopagus", "conjoined twins", "dissected eyes", "fixed tissue"]	{"dissected eyes?": {"yes_questions": {"contexual_properties": ["Does the image show any swelling that could indicate recent trauma, infection, or postmortem changes?", "Is there evidence of cloudiness that might result from autolysis, dehydration, or early degeneration?", "Can you observe any color changes that could be due to blood breakdown, tissue decomposition, or chemical exposure?", "Is there a sign of retinal detachment, possibly following mechanical manipulation, trauma, or decomposition?", "Do you see any hemorrhages that might suggest blunt trauma, vascular injury, or underlying pathology?", "Is tissue thinning apparent, which could result from chronic disease, degeneration, or extended postmortem intervals?", "Can you detect increased intraocular pressure that might occur shortly after acute glaucoma or trauma?", "Is there lens opacity visible, potentially due to cataract formation, aging, or protein denaturation?", "Do you notice abnormal fluid accumulation that could be caused by inflammation, trauma, or breakdown of ocular barriers?", "Is corneal edema present, possibly resulting from hypoxia, endothelial dysfunction, or improper storage conditions?", "Are there pigment changes that might be associated with retinal degeneration, hemorrhage, or prolonged postmortem intervals?", "Can you see alterations in vascularization, such as neovascularization or changes due to chronic disease or trauma?", "Is atrophy of ocular tissues visible, which could indicate chronic degenerative disease or decomposition?", "Do you observe changes in vitreous volume that might result from dehydration, liquefaction, or postmortem changes?", "Are there any structural deformities that could be attributed to congenital anomalies, trauma, or advanced degeneration?"], "properties": ["Is there a structure in the image that measures approximately 24 millimeters in axial length?", "Can you identify an object with a weight close to 7.5 grams?", "Does the image show something with a spherical or slightly ovoid shape?", "Is there a structure that appears white with a transparent region and a colored central area, such as brown, blue, or green?", "Can you see an object with a volume around 6.5 milliliters?", "Does the image contain a structure composed of a transparent outer layer, a lens, an internal lining, a tough outer coat, and a gelatinous interior?", "Is there an object present that could contain epithelial, connective, nervous, and vascular tissues?", "Can you identify a structure that is mostly water by weight, approximately 98%?", "Does the image show an object likely to have 1\u20132% protein content, mainly concentrated in a transparent region and a central disc?", "Is there a structure that might contain 0.2\u20131% lipid content, especially in its internal lining and membranes?", "Can you see an object with a density close to 1.02 grams per cubic centimeter?", "Is there a structure with a firm yet elastic texture and a gelatinous interior?", "Does the image show an object that would have a pH between 7.0 and 7.4?", "Can you identify a structure where pigment concentration varies, with melanin present in a colored ring and an internal lining?", "Is there an object with a transparent region whose refractive index is about 1.336?", "Does the image contain a structure with a transparent outer layer measuring 500 to 550 micrometers in thickness at its center?", "Can you see an object with a central disc approximately 9 to 10 millimeters in diameter?", "Is there a structure that includes a cord-like extension measuring about 35 to 55 millimeters in length?", "Does the image show an object that would be at room temperature, around 20\u201325\u00b0C, after removal?", "Can you identify a structure that contains ten distinct internal layers in its internal lining?"], "relational": ["Does the image show a component of the sensory system involved in vision?", "Can you identify anatomical structures such as the cornea, lens, or retina that are typically revealed upon dissection?", "Is there evidence of principal layers like the fibrous tunic, vascular tunic, or neural tunic?", "Does the image display features such as the iris, sclera, or optic disc?", "Can you observe tissues such as nervous, connective, epithelial, or vascular tissue within any structure?", "Is there a visible connection to a structure that transmits visual information to the brain?", "Does the image suggest that the depicted structures were previously located within the orbital cavities of the head?", "Can you identify any part of the visual pathway, such as the optic nerve, optic chiasm, or optic tract?", "Is there evidence of internal fluids like aqueous humor or vitreous humor within any structure?", "Are there supporting structures present, such as eyelids, extraocular muscles, orbital fat, or lacrimal gland, in proximity to the main object?"], "contexual_behavior": ["Is there a structure in the image that would show reduced photoreceptor activity shortly after injury?", "Can you identify an object that would lose its ability to respond to light stimuli within minutes to hours after being removed from the organism?", "Does the image contain a tissue that would exhibit impaired signal transmission if oxygen supply were insufficient?", "Is there a structure that might demonstrate altered neurotransmitter release during inflammation?", "Can you see an object whose visual processing capacity would decrease after exposure to toxins?", "Does the image show a tissue that could fail to maintain normal ionic balance in response to osmotic stress?", "Is there a structure that would show diminished response to pharmacological agents as its viability decreases over time?", "Can you identify an object that would become more susceptible to oxidative damage during prolonged dissection?", "Does the image contain a tissue that would lose its ability to regenerate after mechanical trauma due to being outside the organism?", "Is there a structure whose electrophysiological properties would change under different temperature conditions due to temperature-dependent ion channel function?"], "functions": ["Does the image show a structure responsible for enabling vision or detecting light?", "Can you identify an object that focuses light onto a specialized layer containing photoreceptor cells?", "Is there evidence of specialized cells such as rods and cones within a layered tissue?", "Does the image include paired structures that could enable binocular vision or depth perception?", "Can you see a component that changes shape to focus on objects at different distances?", "Is there a visible opening whose size might be regulated in response to light intensity?", "Can you identify a structure that transmits signals from a sensory layer to the brain?", "Does the image show features that could participate in regulating circadian rhythms by detecting ambient light?", "Are there protective elements such as folds or fringes that might shield a sensitive surface from debris?", "Can you see a gland or duct system that could be involved in producing or distributing a lubricating fluid?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of increased stratification, with multiple layers of epithelial cells present in a localized area?", "Are nucleoli more frequently visible and sometimes prominent within the nuclei in a specific region?", "Is there a section where the epithelial layer is thicker than normal, with several cell layers visible?"], "relational": ["Does the image contain cells with features such as increased nuclear-to-cytoplasmic ratio or nuclear atypia?", "Can you identify an area in the endometrium, breast ducts, or prostate glands with disrupted tissue architecture?", "Does the image show areas with architectural complexity or cellular pleomorphism compared to surrounding parenchyma?"], "contexual_behavior": [], "functions": ["Is there a lesion that could serve as a precursor to neoplastic progression?", "Can you identify tissue where normal regeneration seems impaired by uncoordinated cell growth?", "Can you identify a region where the normal tissue structure appears disrupted or disorganized?"]}}, "janiceps": {"yes_questions": {"contexual_properties": ["Does the image show evidence of asymmetrical head size during embryonic or fetal development?", "Can you identify abnormal cranial structures that might result from incomplete cranial division in the prenatal period?", "Is there a visible fusion of facial features suggestive of craniofacial abnormality during early gestation?", "Does the image display differences in skull composition, such as variable degrees of fusion or ossification during fetal growth?", "Can you observe variation in neural tissue development that could be influenced by the degree of cranial fusion in utero?", "Is there a detectable change in head circumference that might be identified by prenatal imaging due to partially fused heads?", "Does the image reveal altered bone density in the skull, possibly resulting from abnormal bone formation and fusion during embryonic development?", "Can you see abnormal skin coloration on the heads at birth that could indicate vascular anomalies?", "Is there evidence of tissue or organ duplication that might have occurred during organogenesis as a result of twinning?", "Does the image show changes in the size of shared organs that could be attributed to developmental constraints from conjoined anatomy?"], "properties": ["Does the image show an individual with a head size that appears larger than average due to craniofacial duplication?", "Can you identify a newborn whose weight seems higher than typical for singletons, possibly exceeding 4 kilograms?", "Is there a broad and rounded cranial shape suggestive of bifacial cranium or cranial widening?", "Does the image depict two distinct sets of facial features, each on opposite sides of the head?", "Can you observe evidence of partial brain duplication or fused cerebral hemispheres within the cranial region?", "Is the skin color of the neonate consistent with normal variation for their genetic background?", "Does the length of the newborn appear within the typical range of 45 to 55 centimeters?", "Are there four eyes visible, with two eyes present on each face?", "Can you see two mouths, each corresponding to a separate set of facial features?", "Are there four ears present, with two ears per face?", "Do the facial features appear to be arranged symmetrically on opposite sides of the head?", "Is there a single, centrally located neck supporting both sets of facial features?", "Can you identify duplicated facial bones or partially fused cranial vault bones in the head structure?", "Does the distance between the two faces correspond to the width of the shared cranium?", "Are the facial features arranged in a mirror-image pattern across the sagittal plane?"], "relational": ["Does the image show a single head with two complete faces oriented in opposite directions?", "Can you identify a structure where the cranium is fused but facial features such as eyes, noses, and mouths are duplicated?", "Is there evidence of two sets of orbits, nasal cavities, and mandibles present on one skull?", "Does the image contain duplicated cranial structures, such as two brains or two sets of upper respiratory organs, within a shared torso?", "Can you see a region where the frontal, temporal, or occipital areas of the head appear structurally altered due to facial duplication?", "Is there a visible connection between two faces by shared cranial bone and soft tissue?", "Does the image depict a form of conjoined twinning characterized by craniofacial duplication rather than fusion at the thorax or pelvis?", "Are there duplicated facial bones, such as maxillae and zygomatic bones, present on a single fused cranium?", "Can you observe two faces affecting the head, neck, and upper thorax regions in the image?", "Is there a structure in the image where organ systems in the torso appear shared, but cranial features are duplicated?"], "contexual_behavior": ["Does the image show an individual with two heads that might have difficulty coordinating movement or integrating sensory information?", "Can you identify signs of altered breathing patterns that could result from shared thoracic structures or malformed thoracic organs?", "Is there evidence of reduced cardiac efficiency, such as signs of physical stress, that could be related to duplicated or fused cardiovascular anatomy?", "Does the image depict abnormal feeding behavior, possibly due to both mouths attempting to feed at the same time or interference between oral structures?", "Can you observe features that might indicate difficulty in regulating body temperature, such as duplicated heads or increased surface area?", "Is there any indication of compromised locomotor function, such as impaired coordination between two heads and shared musculoskeletal structures?", "Does the image suggest problems with swallowing or airway protection that could arise from duplicated pharyngeal or laryngeal structures?", "Can you see signs of altered metabolic activity, such as increased tissue mass or duplicated organs, that might affect energy balance?", "Is there visual evidence of increased risk of infection, possibly due to shared or fused organ systems that could facilitate pathogen transmission?", "Does the image suggest a failure to coordinate sensory input between two heads, such as conflicting responses to external stimuli?"], "functions": ["Does the image show a developmental anomaly characterized by craniofacial duplication?", "Can you identify evidence of conjoined twinning involving two faces on a single head?", "Is there visual indication of duplication or fusion of cranial and neural structures?", "Does the image reveal abnormalities that could disrupt normal physiological processes in the head or brain?", "Can you observe features suggesting shared or duplicated brain, airway, or vascular systems?", "Is there evidence of structural fusion that might impair organ function?", "Does the image display abnormal vascular connections or duplications in the head and neck region?", "Can you identify signs of circulatory compromise or hemodynamic instability related to vascular anomalies?", "Is there visual evidence of two brains or partially fused neural tissue that could affect neural coordination?", "Does the image suggest impaired or uncoordinated neural control due to neural fusion or brain duplication?", "Can you observe abnormal airway anatomy, such as duplicated or obstructed respiratory passages?", "Is there indication of respiratory compromise or pulmonary dysfunction due to airway malformation?", "Does the image show features that could disrupt metabolic regulation, such as duplicated or fused hypothalamic regions?", "Can you identify signs of endocrine disruption or hypothalamic anomaly that might affect metabolic balance?", "Is there evidence of duplicated or fused sensory organs or neural pathways that could alter sensory integration?", "Does the image suggest abnormal perception or processing due to sensory duplication or neural integration deficit?", "Can you observe oral or pharyngeal malformations that might hinder effective swallowing or feeding?", "Is there visual indication of digestive impairment or feeding difficulty related to abnormal oral structures?", "Does the image reveal signs of disrupted central nervous system control over vital functions?", "Can you identify features that might lead to homeostatic instability, such as temperature, fluid, or metabolic imbalance?"]}, "no_questions": {"contexual_properties": ["Can you identify a ductal abnormality characterized by the presence of multiple papillary growths and areas resembling apocrine metaplasia?", "Is there evidence of epithelial changes within a ductal lesion that suggest transformation toward apocrine cell characteristics?", "Does the image show a lesion within a ductal structure that contains multiple papillary projections?"], "properties": ["Is there a structure composed of papillary epithelial cells and myoepithelial cells?", "Does the lesion display low nuclear grade and a low mitotic rate?", "Is there an area where hormone receptor expression, such as estrogen or progesterone receptors, would be low or negative in the apocrine regions?"], "relational": ["Does the image reveal structures supported by a myoepithelial layer, basement membrane, or surrounding stroma?", "Can you see a proliferative lesion arising within the mammary gland?", "Is there evidence of changes within lactiferous ducts or terminal duct-lobular units?"], "contexual_behavior": ["Is there evidence of multiple papillary projections inside a ductal space?", "Can you identify areas where the lining of a duct appears to have undergone a change resembling apocrine cells?", "Does the image show any abnormal growths within a ductal structure?"], "functions": ["Is there evidence of tissue remodeling or changes in the surrounding stroma adjacent to ductal lesions?", "Can you identify areas where cellular proliferation appears regulated or where differentiation is evident?", "Does the image suggest increased or modified secretion within the ducts?"]}}, "eyes": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the visual system?", "Can you identify an object located within the orbital cavity of the head?", "Is there a structure connected to the optic nerve visible in the image?", "Does the image contain tissues such as corneal, retinal, or scleral tissue?", "Can you see an object surrounded by bones like the frontal, zygomatic, maxillary, or sphenoid bones?", "Is there evidence of extraocular muscles such as the superior rectus or lateral rectus controlling movement of a structure?", "Does the image show something associated with cranial nerves like the oculomotor, trochlear, or abducens nerves?", "Can you identify a region supplied by the ophthalmic artery or central retinal artery?", "Is there a structure related to glands such as the lacrimal gland or meibomian glands?", "Does the image display external or internal features such as the cornea, iris, lens, retina, or vitreous body?", "Can you see an object protected by eyelids?", "Is there a structure whose position or orientation could be influenced by extraocular muscles?"], "contexual_behavior": [], "functions": ["Is there a structure in the image responsible for enabling vision and visual perception?", "Can you identify an object that focuses light onto a layer containing photoreceptor cells?", "Does the image show a structure that detects and responds to light through specialized cells sensitive to photons?", "Is there evidence of an organ that contributes to color vision using cone cells sensitive to different wavelengths?", "Can you see paired structures that could provide slightly different images for depth perception and binocular vision?", "Does the image contain a feature that adjusts its opening size in response to changes in light intensity?", "Is there a visible component that changes shape to focus on objects at varying distances?", "Can you identify structures capable of smooth pursuit or rapid movement to track moving objects?", "Does the image show protective features such as movable coverings or hair-like projections that could prevent foreign particles from entering?", "Is there evidence of a gland or structure that could produce tears for lubrication of a surface?", "Can you see an object that transmits information to the brain via a prominent nerve pathway?", "Is there a structure that could provide visual cues important for maintaining balance and spatial orientation?", "Does the image include cells or regions specialized for detecting motion within a visual field?", "Can you identify a structure that might transmit light information to regulate circadian rhythms in the brain?"]}, "no_questions": {"contexual_properties": ["Does the image show an auricular structure that appears more prominent during periods of rapid growth or in the presence of craniofacial anomalies?", "Is there loss of normal ear contour, possibly due to scarring, congenital deformities, or previous surgical intervention?", "Does any ear appear red or inflamed, which could be a sign of cellulitis, otitis externa, or dermatitis?"], "properties": ["Can you identify an object whose superior attachment lies beneath the horizontal plane passing through the inner canthi?", "Is there a structure with a length between 6 and 6.5 centimeters, consistent with typical measurements for this region?", "Is there a structure with a smooth skin texture similar to adjacent facial areas?"], "relational": ["Does the auricle or pinna appear to be positioned differently compared to typical anatomy?", "Does the image contain features commonly seen in syndromes such as Down syndrome, Turner syndrome, or Edwards syndrome?", "Can you identify a structure adjacent to the mandible, mastoid process, or zygomatic arch that appears unusual?"], "contexual_behavior": ["Is there an external ear whose placement could disrupt the normal acoustic pathway to the ear canal, especially during head movement?", "Can you identify an external ear whose orientation or structure appears altered in a way that might suggest a craniofacial developmental disorder?", "Can you see an ear whose position or associated features might suggest the presence of a genetic syndrome with additional auditory or craniofacial anomalies?"], "functions": ["Can you identify an anatomical variation that leaves sound localization unchanged?", "Does the image show an external ear whose protective function for the ear canal seems unaffected?", "Can you see an ear structure where the ability to funnel sound waves into the auditory canal appears preserved?"]}}, "cephalothoracopagus janiceps": {"yes_questions": {"contexual_properties": ["Does the image show a case of conjoined twins with a shared head and thorax?", "Is there evidence of two faces oriented in opposite directions on a single head?", "Can you identify a condition where two individuals are fused at the upper body and head regions?", "Does the image depict a rare congenital anomaly involving duplication of facial structures on a shared cranium?"], "properties": ["Does the image show a case where two individuals are conjoined at both the head and the chest regions?", "Can you identify a situation where two faces are present on opposite sides of a shared head?", "Is there evidence of duplicated cranial or facial structures within a single fused upper body?", "Does the image depict a fusion of two bodies with a single head exhibiting two faces?"], "relational": ["Does the image show two faces that appear duplicated on a single upper body?", "Can you identify a continuous anatomical connection between the head and chest regions?", "Is there evidence of fusion between the cranial and thoracic areas?", "Does the image display a structure where the rib cage and sternum are shared by two heads?", "Can you see signs of a fused cranium or joined brain structures?", "Is there a visible joining of the skull base, cervical vertebrae, or thoracic spine?", "Does the image suggest the presence of shared thoracic organs such as the heart or liver?", "Are there duplicated facial features with a single thoracic region beneath them?", "Can you observe major arteries or veins, such as carotid arteries or jugular veins, that are shared between two head regions?", "Is there a clear anatomical boundary at the cranial vault or lower thoracic margin indicating fusion?", "Does the image show upper body regions that are fused while lower abdominal organs appear separated?", "Can you identify a structure affecting the respiratory, cardiovascular, or digestive systems due to fusion of the upper body?"], "contexual_behavior": ["Does the image show an individual with two heads that may have impaired coordination between them?", "Is there evidence of anatomical fusion in the thoracic region that could indicate shared heart or major vessels?", "Can you identify features suggesting that both heads might rely on a single or partially shared respiratory system?", "Does the image display duplicated or malpositioned oral or digestive structures that could affect feeding efficiency?", "Is there a shared body mass or surface area that might disrupt normal heat exchange and thermoregulation?", "Can you see signs of fused or malformed renal or gastrointestinal tracts that could impair waste elimination?", "Does the image suggest the presence of shared vascular structures that might alter circulatory dynamics during physical activity?", "Are there anatomical features indicating a shared lymphatic or hematopoietic system that could compromise immune defense?", "Can you identify shared respiratory or circulatory systems that might limit oxygen delivery during anesthesia or surgical intervention?"], "functions": ["Does the image show individuals with evidence of shared cranial or thoracic organs, suggesting systemic interdependence?", "Can you identify anatomical features indicating fusion of heads and upper bodies that might disrupt coordination of vital organ functions?", "Is there visual evidence of shared or partially fused airways or thoracic cavities that could compromise respiratory function?", "Does the image reveal the presence of conjoined hearts or major vessels that might affect circulatory system regulation?", "Can you observe duplicated or fused brain structures that could impair neural integration or sensory processing?", "Is there any indication of a shared upper digestive tract or anatomical obstruction that could complicate feeding and digestion?", "Does the image suggest altered body surface area or shared metabolic regions that might disrupt thermoregulation?", "Can you see signs of shared hepatic or endocrine organs that could affect metabolic homeostasis?", "Is there visual evidence of shared lymphatic structures that might increase susceptibility to infections?", "Do you observe duplicated or fused neural pathways or musculoskeletal structures that could impair coordination of motor activities?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the tissue in the lesion appear to have a pH close to neutral, around 7.0?", "Is there a lesion that could contain foveolar epithelial cells or mucous cells?", "Can you see features suggesting absent, low-grade, or possibly high-grade dysplasia within a lesion?"], "relational": ["Can you see a structure in an area supplied by branches of the left or right gastric arteries?", "Does the image contain a lesion composed of cells such as foveolar epithelial cells, glandular cells, or inflammatory cells?", "Does the image show a mass adjacent to the gastric lumen or near the muscularis mucosae?"], "contexual_behavior": [], "functions": ["Does the image reveal a lesion that could interfere with digestive processes by causing localized obstruction?", "Can you identify an area that could serve as a site for abnormal cell growth, dysplasia, or neoplastic transformation within the gastric mucosa?", "Does the image show signs of local inflammation, such as recruitment of inflammatory cells around a mucosal lesion?"]}}, "cephalothoracopagus": {"yes_questions": {"contexual_properties": ["Does the image show two individuals with noticeable asymmetry in size that could suggest unequal distribution of shared organs or tissues?", "Is there evidence of abnormal skin color at a region where two bodies are joined, possibly indicating compromised blood flow or vascular anomalies?", "Can you observe differences in organ composition or arrangement between the two individuals, suggesting incomplete duplication or fusion of vital organs?", "Is there an increased overall body weight or bulkiness that might be due to accumulation of shared tissues or fluid retention at a junction?", "Does the image reveal abnormal tissue structures or irregularities at the area where the two bodies are fused, possibly resulting from disrupted tissue differentiation?", "Are there visible changes in the size or shape of the head or thorax between the two individuals, indicating disproportionate growth or malformation of cranial or thoracic structures?", "Can you identify altered or abnormal vascular patterns at the site where the two bodies are joined, which might be consistent with vascular malformations?", "Is there localized swelling or puffiness at the fusion site that could be due to fluid accumulation or lymphatic obstruction?", "Does the image show abnormal bone formation, such as fused or malformed bones, at the area where the two bodies are connected?", "Are there visible signs that suggest differences in organ function or metabolic activity between the two individuals, such as asymmetry in measurable features?", "Can you observe any fluid accumulation at the junction of the two bodies, possibly indicating impaired drainage or increased vascular permeability?", "Is there a change in tissue density or texture at the area of union, which could be due to abnormal tissue composition or fibrosis?", "Does the fusion area display abnormal pigmentation or localized skin changes that might be related to vascular or developmental anomalies?", "Are there differences in limb size between the two individuals, suggesting disproportionate limb growth due to unequal nutrient or blood supply?", "Can you detect abnormal or unequal growth rates in either individual, potentially resulting from differential organ sharing or metabolic imbalance?"], "properties": ["Does the image show an individual whose overall size is similar to that of a term newborn?", "Can you identify a body with two heads that appear fused together and share a single upper torso?", "Is there evidence of two faces or crania that are joined at both the head and chest regions?", "Does the image display a configuration where the upper organs, such as the heart or lungs, might be shared between two heads?", "Are there four limbs visible, with two upper and two lower extremities, or any signs of limb duplication?", "Do the heads appear side by side or partially merged at the cranial region?", "Is there a single, broad chest cavity that could contain shared thoracic organs?", "Can you observe features suggesting a single heart, or possibly two hearts, within a shared thorax?", "Does the vertebral column appear partially fused in the neck and chest areas, with possible duplication below the chest?", "Are the head circumferences of each head within the range typical for newborns, approximately 32 to 38 centimeters?", "Is the skin color consistent with that of a non-conjoined newborn of the same ethnicity?", "Do the facial features appear duplicated, partially merged, or show midline fusion or asymmetry?", "Is the overall length of the body between 45 and 55 centimeters, similar to a term neonate?", "Can you see evidence of fused skulls with possible duplication of brain or facial structures?", "Are there signs that the lower organs might be duplicated while the upper organs are shared?"], "relational": ["Does the image show two individuals with their head and upper chest regions fused together?", "Can you identify a case where the skulls and cervical spines of two bodies are connected?", "Is there evidence of a shared cranial vault or merged facial bones between two individuals?", "Does the image display a fusion that extends from the top of the skull to the upper abdomen?", "Can you see two bodies with a contiguous cranial and thoracic region?", "Is there a visible merging of the neck and upper thorax between two individuals?", "Does the image suggest the presence of shared organ systems such as the upper respiratory, cardiovascular, or digestive systems between two bodies?", "Can you identify a structure where the brain, heart, or liver appears to be joined between two individuals?", "Is there a case of shared or interconnected circulatory systems, such as a common heart or major vessels, visible in the image?", "Does the image show merged cranial or thoracic cavities between two individuals?", "Can you see evidence of connected cerebral hemispheres, brainstem, or cranial nerves between two bodies?", "Is there a fusion involving the nasal cavities, pharynx, larynx, trachea, or upper lungs of two individuals?", "Does the image display a joining of the upper gastrointestinal tract, such as the esophagus, between two bodies?", "Can you observe anatomical boundaries of fusion that include both the cranial and thoracic regions?", "Is there a visible connection of the upper thoracic skeleton, including the thoracic cage, between two individuals?"], "contexual_behavior": ["Does the image show individuals with shared thoracic structures that could limit lung capacity or airway patency?", "Is there evidence of a shared cardiovascular system that might struggle to compensate during physiological stress?", "Can you identify features suggesting incomplete or mismatched neural pathways between conjoined individuals?", "Does the image depict overlapping hepatic or pancreatic tissues that could compromise metabolic processing?", "Is there a visible fusion or abnormality in the gastrointestinal tracts that might affect feeding coordination?", "Can you see anatomical features indicating disrupted thermoregulation due to shared or abnormal hypothalamic control?", "Is there evidence of merged or cross-reactive immune systems that could alter immune responses compared to single individuals?", "Does the image suggest shared or underdeveloped renal or hepatic systems that might decrease waste elimination efficiency?", "Can you identify features that could compromise immune cell production or distribution, affecting infection or inflammation responses?", "Is there anatomical evidence of fused or dysregulated glands, such as the thyroid or pituitary, that might impact endocrine function?", "Does the image show shared hearts or vessels that could impair circulation during physical exertion?", "Is there evidence that shared respiratory or circulatory systems might limit oxygen delivery under hypoxic conditions?", "Can you see signs that shared organ systems could make it difficult to maintain homeostasis during illness?", "Is there anatomical indication of incomplete or conflicting neural circuits that might decrease neural control of movement in response to stress?", "Does the image suggest functional limitations of shared organs that could impair growth or development for both individuals?"], "functions": ["Does the image show individuals with evidence of fused organs or complex anatomical connections?", "Can you identify any signs of compromised organ function or physiological complexity in the depicted structures?", "Is there visual evidence of shared organs that might be functioning under abnormal conditions?", "Does the image suggest an increased risk of organ failure due to impaired efficiency of shared anatomical structures?", "Can you observe features indicating shared or fused hearts or blood vessels, potentially leading to abnormal blood flow?", "Is there any indication of hemodynamic instability or vascular fusion in the circulatory system?", "Does the image show shared or malformed airways or lungs that could compromise respiratory processes?", "Can you see signs of reduced respiratory efficiency or potential for respiratory distress?", "Is there visual evidence of fused or duplicated neural structures that might affect coordination or neural control?", "Do the depicted individuals show features that could lead to conflicting neural signals or coordination challenges?", "Can you identify shared livers or endocrine organs that might disrupt metabolic regulation or homeostasis?", "Is there any indication of difficulties in maintaining metabolic balance or signs of endocrine disruption?", "Does the image suggest shared gastrointestinal tracts or vascular systems that could affect nutrient absorption and distribution?", "Can you observe features that might lead to unequal nutrient delivery or risk of malnutrition?", "Is there evidence of shared or malformed excretory organs that could impair waste elimination?", "Does the image suggest a risk of metabolic waste accumulation or renal dysfunction?", "Can you see fused skeletal or muscular systems that might restrict movement or motor control?", "Is there visual evidence of limited mobility or motor impairment due to anatomical fusion?", "Do the depicted individuals show signs of shared lymphatic tissues or atypical immune system features?", "Is there any indication of altered immune responses or exposure to different antigens in the shared anatomy?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of calcification within the coronary vessels?", "Are there any alterations in structures adjacent to the coronary arteries, such as the epicardium or myocardium?", "Is there a reduction in blood supply to regions like the left ventricle or interventricular septum?"], "contexual_behavior": [], "functions": ["Are there features present that could increase the risk of arrhythmias or impaired contractility in the heart?", "Does the image suggest a mismatch between coronary blood supply and the oxygen needs of the myocardium?", "Does the image reveal signs of chronic inflammation or immune cell infiltration within the coronary vessels?"]}}, "conjoined twins": {"yes_questions": {"contexual_properties": ["Can you identify two individuals in the image who display differences in organ size that might suggest unequal blood supply or asymmetric development?", "Is there evidence of unequal body weights between two connected individuals, possibly indicating growth disparity or metabolic differences?", "Do you observe asymmetrical limb lengths that could be due to uneven musculoskeletal development or differential limb usage?", "Is there abnormal skin coloration present in one of the connected bodies that might indicate vascular anomalies or compromised circulation?", "Can you see a difference in head circumference between the two individuals, which could suggest unequal cranial development or hydrocephalus?", "Are there visible signs that suggest variations in blood composition, such as differences in skin tone or vascular patterns, possibly due to shared or separate circulation?", "Does the image show a shared organ or structure that appears incompletely divided or functionally partitioned between two bodies?", "Is there swelling at the connection site that could be explained by lymphatic obstruction or localized inflammation?", "Can you observe changes in tissue density at the junction, such as areas that look unusually firm or fibrotic?", "Are there visible differences in features that might reflect unequal hormone levels, such as variations in secondary sexual characteristics or growth patterns?", "Is there evidence of abnormal fluid accumulation, such as localized edema, that could be due to impaired lymphatic drainage or cardiac dysfunction in one or both individuals?", "Do you notice differences in bone structure or density, possibly reflecting unequal mechanical loading or nutritional disparities?", "Is there a visible difference in body temperature distribution, such as one individual appearing flushed or pale compared to the other, suggesting altered blood flow or metabolism?", "Can you see differences in muscle mass between the two bodies, which might indicate variations in physical activity or nutritional support?", "Is there a change in skin texture at the junction, such as areas of scarring or chronic friction?", "Are there signs of differing blood pressure, such as one individual having more prominent veins or pallor, that could suggest partially shared or independent cardiovascular systems?", "Do you observe abnormal tissue growth at the site of connection, such as masses or irregularities that could indicate chronic irritation or neoplastic changes?", "Is there visual evidence of changes in organ composition, such as differences in tissue color or consistency, possibly due to unequal metabolic exchange?", "Can you identify differences in apparent metabolic rates, such as one individual appearing more energetic or with different body composition?", "Is there discoloration at the junction area, such as bluish or darkened skin, that might result from impaired venous return, local hypoxia, or chronic pressure?"], "properties": ["Does the image show two anatomically connected bodies with evidence of physical fusion?", "Can you identify a case where there is thoracic, abdominal, pelvic, or cranial fusion between two individuals?", "Is there visual evidence of organ sharing, such as a single liver or heart serving both bodies?", "Does the image suggest the presence of shared gastrointestinal or genitourinary organs between two connected individuals?", "Can you observe asymmetry or partial symmetry in the distribution of body parts between the two connected bodies?", "Is there a noticeable difference in limb length, torso size, or head circumference between the two fused individuals?", "Does the total number of limbs visible range from four to eight, suggesting variable limb count due to physical fusion?", "Can you see any signs of fused skulls or shared facial structures, particularly in the cranial region?", "Is there evidence of shared vascular structures, such as hepatic veins or cardiac vessels, between the two bodies?", "Does the image depict two neonates with normal skin color for their genetic background?", "Can you estimate if the combined birth weight of the two connected individuals falls within the low birth weight range of 2.5 to 4.5 kilograms?", "Is there any indication that the gestational age at birth is preterm, around 34 to 36 weeks?", "Does the head circumference of either individual appear to be within the normal neonatal range of 33 to 36 centimeters?", "Can you infer from the image whether the two connected individuals are genetically identical?"], "relational": ["Does the image show two individuals with a visible connection at regions such as the thorax, abdomen, pelvis, or head?", "Can you identify any shared anatomical structures, such as a single liver or heart, between two bodies?", "Is there evidence of fusion involving organ systems like the digestive or circulatory systems?", "Do you observe tissues such as skin, muscle, or bone forming a bridge between two individuals?", "Are there skeletal elements, such as the sternum, vertebrae, pelvic bones, or skull, that appear joined between two bodies?", "Does the image suggest the presence of shared blood vessels or cross-circulation between two individuals?", "Can you see duplication or sharing of organs like the intestines, kidneys, or bladder between two connected bodies?", "Is there a visible fusion along anatomical planes such as sagittal, transverse, or coronal between two individuals?", "Do the thoracic, abdominal, pelvic, or cranial cavities appear to be connected between two bodies in the image?", "Are there points of attachment at the chest, abdomen, pelvis, head, or spine linking two individuals?"], "contexual_behavior": ["Does the image show individuals whose anatomy suggests that vital organs might be shared or incompletely separated, potentially leading to compromised physiological processes?", "Can you identify evidence of anatomical fusion that could restrict independent movement or joint articulation?", "Is there visual indication of extensive vascular connections that might result in unbalanced circulation under physical or hemodynamic stress?", "Does the image suggest the possibility of altered metabolic rates due to unequal tissue distribution or shared organs?", "Can you see features that imply a shared digestive tract, which could affect nutrient absorption?", "Is there evidence of shared excretory organs, such as kidneys or bladder, that might impair waste elimination for both individuals?", "Does the anatomy depicted suggest that heat dissipation or retention could be affected by shared body mass or surface area, potentially altering thermoregulation?", "Is there a visible indication that total lung capacity or ventilation might be reduced due to shared lungs?", "Can you identify a situation where a single heart might be responsible for the circulatory demands of two bodies, possibly leading to insufficient cardiac output?", "Does the image suggest the presence of shared circulation, which could increase susceptibility to infection by facilitating pathogen transfer?", "Is there anatomical evidence that could indicate a slower healing process after surgery due to shared vascular supply or increased physiological stress?", "Can you see signs that suggest shared endocrine organs, which might disrupt hormonal regulation?", "Does the depicted anatomy imply that a shared nervous system could alter pain perception or sensory processing?", "Is there visual evidence that the risk of organ failure could be increased during critical illness due to shared organs?", "Can you identify features that might indicate a difference in growth rate compared to non-fused individuals, possibly due to metabolic or anatomical constraints?", "Does the image suggest that compensation for blood loss could be affected by the extent of shared vascular connections?", "Is there anatomical evidence that the function of shared organs might deteriorate with age due to cumulative physiological stress?", "Can you see signs that drug metabolism could be altered if a single liver is shared between two individuals?", "Does the depicted anatomy suggest that immune response or pathogen exposure might differ between the individuals due to shared immune organs or cross-circulation?", "Is there evidence that the stress response during illness could be affected by shared physiological systems or organs?"], "functions": ["Does the image show individuals who might experience challenges in maintaining homeostasis due to interconnected anatomical structures?", "Can you identify a case where organ function could be compromised by the fusion of two bodies?", "Is there evidence of anatomical fusion that could require physiological coordination between two individuals?", "Does the image suggest the possibility of shared circulatory systems, which might lead to mixed blood flow or cross-circulation complications?", "Can you see features indicating that nutrient distribution or oxygen delivery might be affected by shared vascular connections?", "Is there a scenario where metabolic processes or drug metabolism could be complicated by the presence of shared organs?", "Does the image suggest that waste elimination might be challenging due to altered anatomical pathways?", "Can you identify overlapping tissues or organs that could result in increased susceptibility to infection or autoimmune reactions?", "Is there visual evidence of duplicated organs that might provide functional redundancy or independence?", "Does the image show anatomical features that would require coordinated regulation of shared organs?", "Can you see signs of integrated feedback mechanisms or compensatory physiological adjustments maintaining balance between two individuals?", "Is there evidence of adaptive anatomical connections that could enable survival with shared vital organs?", "Does the image suggest the need for complex motor coordination or voluntary cooperation between two bodies?", "Can you identify features indicating shared or separate nervous systems that might affect sensory perception or motor control?", "Is there visual evidence of altered digestive flow or gastrointestinal sharing that could impact nutrient absorption or risk of obstruction?", "Does the image suggest the presence of integrated systemic regulation or compensatory organ function to maintain physiological balance?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display a compartment that is connected to the cytosol and the Golgi apparatus?", "Does the image show an organelle interacting with the Golgi apparatus or mitochondria?", "Does the image show a structure that is part of the endomembrane system?"], "contexual_behavior": ["Is there a region where function is reduced due to oxidative stress, leading to protein damage and impaired processes?", "Can you see a component that fails to maintain membrane lipid balance in the context of metabolic syndrome due to disrupted lipid metabolism?", "Is there evidence of decreased detoxification activity in association with liver disease, such as cirrhosis or hepatitis?"], "functions": ["Is there an organelle present that participates in calcium signaling or interacts with signaling proteins?", "Can you see a region where ribosomes might be attached for mRNA translation?", "Is there a visible feature associated with the transport of proteins to the Golgi apparatus?"]}}, "dissected eyes": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a diameter between 2 and 2.5 centimeters, depending on the species?", "Can you identify an object that weighs approximately 7 to 8 grams in adult humans?", "Is there a structure with a spherical or slightly ovoid shape present?", "Does the image contain an object with a white outer layer, a colored central ring, and a transparent covering?", "Can you see something with a volume of about 6.5 to 7 milliliters in adult humans?", "Is there a structure that contains tissues such as retina, cornea, lens, sclera, choroid, and vitreous body?", "Does the image include an object with a firm exterior and a gelatinous interior?", "Can you identify a structure whose interior contains about 98% water and whose lens contains 65\u201370% water?", "Is there an object present that contains crystallins in one part and opsins in another?", "Does the image show a structure where the lipid content is mainly found in the retina, making up about 5\u201310% of that tissue?", "Can you see an object that contains minerals such as sodium, potassium, calcium, and magnesium?", "Is there a structure with a density close to that of water, around 1.02 grams per cubic centimeter?", "Does the image include something with a neutral pH, between 7.0 and 7.4?", "Can you identify an object in adult humans with a diameter of about 24 millimeters?", "Is there a structure where melanin pigment is present in both a colored ring and a pigmented epithelial layer?"], "relational": ["Does the image show a structure that is part of the visual or sensory system?", "Can you identify anatomical features such as the cornea, lens, or retina?", "Is there evidence of neural, connective, epithelial, or vascular tissue within any dissected structure?", "Does the image display components like the sclera, iris, choroid, or vitreous body?", "Can you see a structure directly connected to a neural pathway that transmits visual information to the brain?", "Are the fibrous, vascular, or neural layers visible in any of the dissected regions?", "Does the image reveal the presence of fluids such as aqueous humor or vitreous humor?", "Is there a structure connected to the optic chiasm or optic tract?", "Can you identify something located in the orbital region or eye socket of the head?", "Are supporting structures such as extraocular muscles, eyelids, lacrimal glands, or orbital fat visible in the image?"], "contexual_behavior": ["Does the image show a structure that would exhibit reduced photoreceptor activity after exposure to substances disrupting cellular metabolism?", "Is there evidence of impaired light response in a tissue that might have experienced oxygen deprivation?", "Can you identify a sample where neurotransmitter release could be altered due to metabolic stress affecting synaptic function?", "Does the image include a specimen that may have lost its ability to generate electrical signals after prolonged storage?", "Is there a structure that would display decreased visual pigment regeneration in darkness if metabolic pathways were disrupted?", "Can you see a tissue that might be more susceptible to oxidative damage during inflammation when antioxidant defenses are low?", "Does the image contain a sample where synaptic transmission could be diminished following mechanical injury?", "Is there a structure that would show reduced responsiveness to light stimuli at low temperatures due to slowed enzymatic activity?", "Can you identify a tissue that might have impaired signal transduction in the presence of drugs inhibiting phototransduction pathways?", "Does the image show a specimen that could recover functional activity after reoxygenation following an anoxic period?", "Is there a structure that might alter its electrophysiological properties during nutrient deprivation affecting ion channels?", "Can you see a sample that would fail to maintain ionic gradients after membrane disruption caused by injury?", "Does the image include a tissue that could increase spontaneous activity after exposure to neurotoxins altering neuronal excitability?", "Is there a structure that would demonstrate reduced adaptation to changing light conditions after photobleaching impairs photopigment recovery?", "Can you identify a specimen that might show impaired function due to enzymatic degradation of structural proteins and membranes during dissection?"], "functions": ["Does the image show a specimen that could be used for direct examination of ocular structure and function in experimental analysis?", "Is there evidence of a preparation that would allow researchers to access neural circuits involved in image formation?", "Can you identify a sample suitable for studying photoreceptor function and light detection?", "Does the image contain tissue that could be used to investigate synaptic activity within the retina or optic nerve?", "Is there a structure present that would enable analysis of visual transduction or adaptation mechanisms?", "Can you see a preparation that could be exposed to light stimuli for measuring electrophysiological or molecular responses?", "Does the image include a model that could be used to investigate pathophysiological changes associated with ocular diseases?", "Is there a specimen that would allow direct application of drugs to observe pharmacological effects on ocular tissues?", "Can you identify tissue suitable for assessing retinal function through measurements of electrical activity or morphological changes?", "Does the image show a preparation that could facilitate research on cellular differentiation or regenerative processes in the eye?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure whose wall appears soft and rugose due to the presence of folds?", "Is there a structure likely to have substantial collagen content, contributing to strength and elasticity?", "Is there a structure that could support a microbial community dominated by Lactobacillus species?"], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify a region that is anatomically connected to the cervix at its upper end and the vulva at its lower end?", "Can you see a structure composed of stratified squamous epithelium, smooth muscle, and connective tissue?"], "contexual_behavior": ["Does the image show increased susceptibility to irritation that might follow disruption of the mucosal barrier, such as after douching?", "Does the image suggest a shift in microbial balance or flora composition that could result from hormonal therapy?", "Does the image suggest reduced lubrication that could be associated with decreased estrogen levels during menopause?"], "functions": ["Does the image show a region that might maintain an acidic environment due to lactic acid production?", "Is there a structure that facilitates the deposition of sperm during sexual intercourse?", "Can you identify a passageway that enables the exit of menstrual blood from the uterus?"]}}, "fixed tissue": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a specimen in the image that appears pale, whitish, or light tan in color?", "Can you identify a sample that looks firm and rubbery in texture?", "Does the image show a block-shaped or irregularly shaped sample that could have been trimmed from a larger specimen?", "Is there an object whose size appears to be within the range of a few millimeters to several centimeters?", "Can you see a sample that might weigh between 0.1 and 10 grams based on its apparent size and density?", "Is there a structure that could have a reduced water content, around 60\u201370%?", "Does the image contain a specimen that might have a density between 1.05 and 1.10 g/cm\u00b3?", "Can you identify an object that may contain proteins, lipids, nucleic acids, and residual chemicals from processing?", "Is there evidence of a sample that could contain residual fixative agents such as formaldehyde, glutaraldehyde, or ethanol?", "Does the image show a specimen that might have a pH close to neutral, between 6.8 and 7.4?", "Can you see a sample that would likely have a high protein content, making up most of its dry weight?", "Is there a specimen that could have less than 10% lipid content due to processing?", "Does the image include a sample that might have only a small fraction of nucleic acids, possibly fragmented?", "Can you identify a specimen that would be expected to have a high degree of protein cross-linking?", "Is there evidence of a sample that might contain less than 1% formaldehyde by weight after processing?", "Does the image show a specimen with excellent preservation of cellular and structural detail?", "Can you see a sample whose color appears stable but may show signs of gradual fading or yellowing?", "Is there a specimen that could have undergone shrinkage of about 10\u201320% after processing?", "Does the image contain a sample that might have a refractive index between 1.45 and 1.50?", "Can you identify a thin section, possibly 4 to 10 micrometers thick, prepared for microscopic examination?"], "relational": ["Does the image show a chemically preserved sample derived from an organ or tissue?", "Can you identify a specimen that could originate from any organ system, such as the nervous or cardiovascular system?", "Is there a preserved anatomical structure that might represent a biopsy or tumor?", "Does the image contain a sample that could be from the head, thorax, abdomen, or limbs?", "Can you see a structure that may include cell types like epithelial cells, muscle cells, neurons, or immune cells?", "Is there a specimen that appears to be part of a larger anatomical structure, such as an organ or tissue block?", "Does the image show a sample containing substructures like blood vessels, glands, or extracellular matrix?", "Can you identify a specimen that has undergone a preservation process to maintain structural integrity?", "Is there a sample that could represent an organ commonly studied in histology, such as the liver, kidney, lung, or brain?", "Does the image allow you to observe preserved features such as cellular morphology, tissue architecture, nuclei, or cytoplasm?"], "contexual_behavior": ["Is there evidence in the image of tissue that no longer participates in metabolic processes due to chemical treatment?", "Can you identify a sample that appears resistant to enzymatic degradation, possibly due to cross-linking by agents like formaldehyde?", "Does the image show tissue where antigen detection might be compromised, suggesting possible overexposure to fixatives?", "Is there a region where the uptake of staining reagents appears altered, potentially reflecting changes in permeability from different fixative types?", "Can you observe any loss of cellular structure that might indicate incomplete or suboptimal preservation?", "Does the sample show signs of nucleic acid loss, such as diminished nuclear staining, possibly due to prolonged storage or acidic conditions?", "Is there evidence of reduced immunoreactivity in areas that may have been exposed to high temperatures during processing?", "Can you identify tissue that appears less suitable for molecular analysis, perhaps due to excessive cross-linking or fragmentation?", "Does the image suggest differences in protein cross-linking patterns that could result from the use of various fixatives like aldehydes or alcohols?", "Is there a region where enzyme activity appears absent, possibly due to denaturation or disruption of protein active sites by fixatives?"], "functions": ["Does the image show a biological sample that appears stabilized for research or experimental analysis?", "Can you identify a specimen where cellular structures seem well-preserved, suggesting cross-linking of proteins has maintained architectural integrity?", "Is there evidence that enzymatic degradation has been prevented, indicating inactivation of endogenous enzymes in the sample?", "Does the sample in the image appear suitable for long-term storage, with no visible signs of biological decay?", "Can you see a tissue where protein epitopes might be preserved, making it compatible with immunohistochemistry procedures?", "Is there a specimen that appears morphologically stable, allowing for detailed microscopic examination?", "Does the sample seem to have halted biological processes, supporting accurate analytical assessment?", "Can you identify a tissue where the original cellular and extracellular matrix structure is maintained, preventing autolysis?", "Is there a sample that retains diagnostic features necessary for histological evaluation in pathology?", "Does the specimen appear compatible with molecular analysis techniques, such as PCR or sequencing, due to stabilized nucleic acids and proteins?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a localized growth present in regions like the head and neck, extremities, abdomen, or pelvis?", "Can you identify a well-demarcated structure within organs like the skin, brain, uterus, breast, or colon?", "Can you identify a mass with clear anatomical boundaries, such as a basement membrane or organ capsule?"], "contexual_behavior": [], "functions": ["Can you identify a mass that compresses or displaces surrounding anatomical structures without directly invading them?", "Does the image reveal a well-circumscribed lesion that distorts normal tissue architecture by displacement rather than infiltration?", "Can you identify a mass that induces symptoms related to pressure on adjacent anatomical structures?"]}}}
[ { "answer": "opened skull showing base with two foramina magna", "extracted_concepts": [ "base", "opened skull", "foramina magna" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "base", "two foramina magna", "opened skull", "image" ], "question": "does this image show opened skull showing base with two foramina magna?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "skull" ], "question": "is bone, skull present?" }, { "answer": "conjoined twins cephalothoracopagus janiceps", "extracted_concepts": [ "conjoined twins", "cephalothoracopagus", "janiceps" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "conjoined twins", "cephalothoracopagus", "janiceps" ], "question": "is conjoined twins cephalothoracopagus janiceps present?" }, { "answer": "bone, skull", "extracted_concepts": [ "bone", "skull" ], "question": "what is present?" }, { "answer": "conjoined twins cephalothoracopagus janiceps", "extracted_concepts": [ "conjoined twins", "cephalothoracopagus", "janiceps" ], "question": "what is present?" } ]	["two foramina magna", "base", "opened skull", "image", "bone", "janiceps", "foramina magna", "skull", "cephalothoracopagus", "conjoined twins"]	{"two foramina magna": {"yes_questions": {"contexual_properties": ["Does the image show two openings at the base of the skull that appear enlarged, which could be associated with conditions like Chiari malformation or increased intracranial pressure?", "Can you identify two structures that seem narrowed, possibly due to congenital anomalies, bone overgrowth, or craniosynostosis?", "Are there any signs of shape changes in paired skull base openings that might suggest developmental disorders, trauma, or pathological bone remodeling?", "Is there evidence of abnormal bone growth near two adjacent foramina, as seen in disorders such as osteopetrosis or Paget\u2019s disease?", "Do the paired openings appear asymmetrical, which could indicate unilateral bone lesions, tumors, or congenital malformations?", "Can you observe increased size variation between two adjacent foramina, potentially reflecting genetic diversity or skeletal dysplasia?", "Are the margins of two neighboring skull base openings irregular, possibly due to bone erosion, infection, or neoplastic invasion?", "Do you see signs of erosion affecting two adjacent foramina, which might be caused by chronic inflammatory disease, metastatic cancer, or osteomyelitis?", "Is there any indication that either of the two openings is obstructed by a mass, herniated brain tissue, or a congenital membrane?", "Can you detect calcification within or around two adjacent foramina, as might occur in metabolic bone disorders or after chronic inflammation?", "Do the positions of two neighboring skull base openings appear altered, possibly due to cranial base fracture, developmental anomaly, or surgical intervention?", "Is there evidence of abnormal tissue composition, such as neoplastic infiltration, fibrosis, or congenital tissue anomalies, within the area of two adjacent foramina?", "Do the paired openings appear compressed, which could be a result of mass effect from a tumor, edema, or herniation?", "Are there changes in density\u2014such as increased sclerosis, lytic lesions, or calcification\u2014visible in the region of two adjacent foramina?", "Do you observe deformation of two neighboring skull base openings, potentially due to congenital malformation, trauma, or bone disease?"], "properties": ["Does the image show two openings at the base of the occipital bone in the posterior cranial fossa?", "Can you identify a pair of structures with an oval or somewhat round shape located in the posterior cranial fossa?", "Are there two foramina present, each measuring approximately 35 mm anteroposteriorly and 30 mm transversely?", "Is there evidence of duplication of a large foramen at the base of the skull, rather than the usual single opening?", "Can you see two openings surrounded by compact and cancellous bone of the occipital region?", "Are there two structures with a cross-sectional area of about 800\u2013900 mm\u00b2 each?", "Does the image display two openings in bone that appears pale yellowish-white, consistent with cranial bone?", "Is there a pair of foramina with an estimated volume of around 2,000\u20132,500 mm\u00b3 each?", "Do the two openings show minimal developmental variation in size, or is there noticeable asymmetry?", "Is the distance between the two large openings variable, reflecting a rare anatomical variation?"], "relational": ["Is there a structure visible at the base of the skull?", "Can you identify an opening associated with the occipital bone?", "Does the image show features located in the posterior region of the cranial cavity?", "Is there an area through which the medulla oblongata passes?", "Can you see an opening that transmits vertebral arteries?", "Is there a structure traversed by the spinal accessory nerve?", "Does the image show an opening connected to the dura mater or pia mater?", "Can you identify a junction between the cranial cavity and the vertebral canal?", "Is there a structure adjacent to the cisterna magna or the upper cervical spinal canal?", "Are there openings near the jugular foramen or hypoglossal canal visible in the image?"], "contexual_behavior": ["Does the image show evidence of a congenital malformation, such as occipital encephalocele or Chiari malformation, that could disrupt normal anatomical development at the craniospinal junction?", "Is there a visible reduction in cerebrospinal fluid flow or signs of increased intracranial pressure that might suggest compression or obstruction at the level of the foramen magnum?", "Can you identify herniation of the cerebellar tonsils that could partially or completely block openings at the craniospinal junction, as seen in Chiari malformation?", "Does the image reveal a posterior fossa tumor or mass effect that may compromise brainstem circulation or displace neural structures near the craniospinal junction?", "Is there evidence of neural tissue herniation through the craniospinal opening, possibly due to trauma or increased pressure?", "Can you see signs of hydrocephalus, such as enlarged ventricles, that might indicate altered cerebrospinal fluid drainage at the craniospinal junction?", "Does the image suggest a blockage or anatomical distortion at the craniospinal opening that could affect pressure gradients between the cranial and spinal compartments?", "Is there any indication that cerebrospinal fluid outflow through the craniospinal junction is increased, such as during a Valsalva maneuver or transient pressure changes?", "Can you identify any masses, congenital anomalies, or edema that might obstruct the passage at the craniospinal opening and impair neural function?", "Does the image show degenerative changes in bone or ligaments at the craniospinal junction that could compromise the protection of neural structures?"], "functions": ["Does the image show major openings at the base of the skull that allow neural and vascular structures to pass between the cranial cavity and spinal canal?", "Can you identify structures that enable the medulla oblongata and associated nerves to transition from the brain to the spinal cord?", "Is there a visible conduit for cerebrospinal fluid to flow between the cranial and spinal subarachnoid spaces?", "Does the image contain bony features that protect the brainstem and spinal cord while permitting necessary neural and vascular connections?", "Can you see openings that maintain anatomical and functional continuity between the cranial cavity and the vertebral canal?", "Are there structures present that allow vertebral arteries and other blood vessels to reach the brain and spinal cord?", "Does the image show features involved in balancing intracranial and spinal pressure by permitting cerebrospinal fluid movement and accommodating pressure changes?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a region where the bone thickness measures between 2 and 4 mm despite overall enlargement?", "Can you see a bony structure with a surface area greater than 150 mm\u00b2?", "Does the image display a bony depression with an enlarged height, width, or depth compared to normal reference values?"], "relational": ["Is there a structure bordered laterally by the sphenoid bone?", "Does the image reveal an enlarged space that could indicate pituitary gland enlargement or pathology?", "Can you identify a dural fold, such as the diaphragma sellae, overlying a bony cavity?"], "contexual_behavior": ["Does the image suggest a structural abnormality that could hinder hormonal adaptation during puberty or pregnancy?", "Does the image show evidence of a structure that could compress or displace pituitary tissue, as seen in conditions like empty sella syndrome or pituitary tumors?", "Can you identify an abnormality that could interfere with the regulation of endocrine functions by affecting hormone synthesis or release?"], "functions": ["Is there a feature that might influence cerebrospinal fluid dynamics, possibly leading to conditions like empty sella syndrome?", "Is there visual evidence of a cranial alteration that might be associated with neurological symptoms such as headaches or visual disturbances?", "Can you identify any signs that suggest possible disruption of normal hormone regulation due to changes in a bony cranial structure?"]}}, "base": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears enlarged, possibly due to inflammation, edema, or a tumor?", "Can you identify an area that seems reduced in size, which might suggest atrophy, ischemia, or degeneration?", "Does any region show a change in color that could be explained by hemorrhage, necrosis, or pigment deposition?", "Is there a part that looks heavier or more swollen, potentially from fluid accumulation, cellular infiltration, or calcification?", "Can you see evidence of tissue loss or shrinkage, which might indicate necrosis, atrophy, or resorption?", "Is there a visible change in composition, such as increased fibrosis, calcification, or infiltration by abnormal cells?", "Does any area appear denser than usual, possibly due to calcification, fibrosis, or increased cellularity?", "Can you identify a region that looks less dense, which could be caused by edema, cystic changes, or tissue loss?", "Is there an abnormal texture present, as might be seen with fibrosis, necrosis, or tumor formation?", "Does any structure show accumulation of unusual substances, such as amyloid, lipid, or hemosiderin?", "Are there visible structural changes suggestive of remodeling, scarring, or neoplastic transformation?", "Is there a swollen area that could be attributed to inflammation, infection, or trauma?", "Can you see a region that appears shrunken, possibly due to atrophy, ischemia, or chronic disease?", "Does any part of the image show discoloration that could result from hemorrhage, necrosis, or pigment accumulation?", "Are there abnormal measurable features in the image that might correspond to laboratory or imaging findings seen in pathological processes?"], "properties": ["Does the image show a chemical substance that could accept protons or contain hydroxide ions?", "Is there a material present that might have a pH greater than 7 in aqueous solution?", "Can you identify something that could be classified as alkaline?", "Does the image include a substance that could be sodium hydroxide or ammonia?", "Is there an object whose molecular weight could correspond to 40 g/mol or 17 g/mol?", "Can you see a solution or solid that might have a concentration between 0.01 M and 1 M?", "Is there a material that appears colorless in solution or white as a solid?", "Does the image show a solid that could have a density around 2.13 g/cm\u00b3 or a solution with density close to water?", "Can you identify a substance that is likely highly soluble in water?", "Is there a solid that might have a melting point near 318\u00b0C or 360\u00b0C?", "Does the image contain a material that could decompose before boiling at around 1,388\u00b0C?", "Can you see a chemical with a structural formula similar to NaOH or NH3?", "Is there an object that might emit a pungent odor, or is otherwise odorless?", "Does the image show a solution with a refractive index close to 1.33?", "Is there a liquid that could conduct electricity well due to mobile ions?", "Can you identify a solution that might have an osmolarity of about 2 Osm/L if it were 1 M in concentration?", "Is there a liquid whose viscosity is similar to water, or slightly higher if concentrated?"], "relational": ["Is there a region at the inferior or proximal end of a larger anatomical structure visible in the image?", "Can you identify an area where supporting tissues or blood vessels attach to a broader part of an organ or bone?", "Does the image show a segment containing connective tissue, muscle, or epithelial layers at the foundational aspect of a structure?", "Are there visible ligaments, fascia, or skeletal elements providing support to the lower or proximal portion of an anatomical structure?", "Can you see neighboring segments or surfaces adjacent to the broader end of an organ or bone?", "Is there a structure in the image that is opposite to an apex, forming the more stable or wider end?", "Does the image include a foundational region that could belong to the cardiovascular, respiratory, or skeletal system?", "Are there entry or exit points for vessels, nerves, or ducts located at the proximal or inferior aspect of a structure?", "Can you identify tendons, membranes, or adjacent organs connecting to the broader or more stable end of an anatomical entity?", "Is there a part of a structure that is positioned at the lower, proximal, or foundational location relative to its other regions?"], "contexual_behavior": ["Does the image show evidence of a condition where hydrogen ion loss or bicarbonate gain could lead to elevated blood pH?", "Is there a visual indication of chronic kidney disease that might suggest reduced buffering capacity due to impaired bicarbonate regeneration?", "Can you identify signs of prolonged vomiting that could result in increased bicarbonate concentration in the blood?", "Does the image suggest respiratory acidosis, where elevated carbon dioxide might impair the effectiveness of the bicarbonate buffer system?", "Is there evidence of recent antacid ingestion that could increase neutralization of gastric acid?", "Can you see features consistent with renal failure that might indicate decreased excretion and retention of bicarbonate?", "Does the image suggest compensatory mechanisms for acidosis, such as increased renal conservation of bicarbonate?", "Is there a sign of severe diarrhea that could be associated with accelerated loss of bicarbonate in intestinal fluids?", "Can you identify features of strenuous exercise that might challenge the bicarbonate buffer system due to increased lactic acid production?", "Does the image show any indication of changes in blood pH that could prompt the body to adjust bicarbonate levels for acid-base homeostasis?", "Is there evidence of sepsis that could be linked to impaired bicarbonate production and decreased contribution to acid-base balance?", "Can you see signs of excessive bicarbonate administration that might result in base accumulation and metabolic alkalosis?", "Does the image suggest an endocrine disorder such as hyperaldosteronism that could disrupt renal handling of bicarbonate?", "Is there evidence of dehydration that might alter renal reabsorption and excretion of bicarbonate?", "Can you identify correction of electrolyte imbalances, such as hypokalemia, that could restore normal renal processing of bicarbonate?"], "functions": ["Is there evidence in the image of a process or structure that helps maintain physiological pH by accepting hydrogen ions?", "Can you identify a feature involved in neutralizing excess acids to support acid-base balance?", "Does the image show a component that contributes to blood pH stability by buffering hydrogen ions?", "Is there a visible process where acids are neutralized through the formation of water or weak acids?", "Can you see evidence of metabolic activity that involves proton transfer or maintenance of optimal pH for enzyme function?", "Does the image depict a system or structure that participates in buffering, such as the bicarbonate buffer?", "Is there a feature that helps stabilize intracellular or extracellular pH environments for cellular homeostasis?", "Can you identify a region where enzyme activity might be facilitated by an optimal pH environment?", "Does the image show evidence of respiratory or renal compensation mechanisms that correct acid-base imbalances?", "Is there a process or structure present that could help prevent acidosis by supporting the body's buffering capacity?"]}, "no_questions": {"contexual_properties": ["Can you detect loss of normal anatomical structure that could be due to destruction or distortion from trauma, infection, or malignancy?", "Can you identify abnormal shadows that could be due to tumors, infiltrates, or the presence of a foreign body?", "Does the image show any abnormal soft tissue or bone growths that might represent a mass or tumor?"], "properties": ["Is the image quality consistent with an intensity of 10^4 to 10^6 photons per square millimeter per second?", "Is the field size of the image within the range of 18 \u00d7 24 centimeters to 35 \u00d7 43 centimeters?", "Can you infer that the voltage used to generate the image was between 40 and 150 kilovolts peak?"], "relational": ["Can you assess bone alignment or joint spaces in the image?", "Can you see organs such as the lungs or heart in the image?", "Is it possible to evaluate organ position within the thoracic or abdominal cavity?"], "contexual_behavior": ["Is there a reduction in the ability to detect tumors when dense tissue or overlapping structures are present in the image?", "Does the image have limited diagnostic value for detecting early-stage osteoarthritis due to the invisibility of initial cartilage loss?", "Can you determine if the image provides primarily structural rather than functional information, especially in the context of acute inflammation?"], "functions": ["Can you identify any discontinuities or abnormal alignments in bones that might indicate a fracture?", "Can you see features that would help guide a medical procedure, such as the placement of a catheter or orthopedic hardware?", "Can you assess the alignment of bones, joint spaces, or signs of degeneration in joints or the spine?"]}}, "opened skull": {"yes_questions": {"contexual_properties": ["Is there evidence of increased bleeding that could suggest trauma, vascular injury, or a problem with blood clotting?", "Can you observe swelling of tissues that might indicate inflammation, infection, or fluid accumulation within the cranial cavity?", "Is there any discoloration of bone that could be due to hemorrhage, bruising, or a chronic bone disorder?", "Do you see areas where the bone texture appears abnormal, possibly consistent with osteoporosis, infection, or tumor infiltration?", "Is there visible thinning of bone that might be associated with osteoporosis, long-term steroid use, or a metabolic bone disorder?", "Can you identify regions of bone thickening that could suggest Paget\u2019s disease, chronic infection, or hyperostosis?", "Are there any fractures or cracks present that might be the result of blunt force, weakened bone, or surgical intervention?", "Do you notice any accumulation of fluid that could indicate a subdural hematoma, abscess, or leakage of cerebrospinal fluid?", "Is there abnormal tissue growth visible that could correspond to a tumor, granuloma, or meningioma?", "Can you detect changes in bone density that might be caused by a metabolic bone disorder, malignancy, or chronic infection?", "Are there signs of infection such as pus or redness that could be due to osteomyelitis, meningitis, or a scalp infection?", "Is there evidence of bone softening that might suggest rickets, osteomalacia, or chronic infection?", "Do you observe erosion of the bone surface that could be caused by chronic infection, tumor invasion, or pressure from a nearby mass?", "Is there abnormal coloration of the meninges that could indicate meningeal hemorrhage, infection, or chemical irritation?", "Can you see any effects that might suggest increased intracranial pressure, such as swelling from cerebral edema, a mass lesion, or hydrocephalus?"], "properties": ["Is there a structure in the image that measures approximately 20 to 25 centimeters in length and 15 to 20 centimeters in width?", "Can you identify an object that would weigh around 1.2 to 1.5 kilograms in adults?", "Does the image show something with an oval or rounded shape and a domed vault?", "Is there a bone present that appears off-white to pale yellow in color?", "Can you see a structure where the bone thickness ranges from 4 to 8 millimeters depending on the region?", "Is there an object with a smooth inner surface and a slightly rough outer surface?", "Does the image contain a structure composed mainly of hydroxyapatite, collagen, and water?", "Can you identify a bone with a density of about 1.5 to 2.0 grams per cubic centimeter?", "Is there a cavity visible that could hold approximately 1200 to 1500 milliliters in volume?", "Does the bone in the image appear to have a water content of roughly 10 to 20 percent by weight?", "Is there a structure where calcium phosphate accounts for about 60 to 70 percent of its mass?", "Can you see an object that would likely be at room temperature, around 20 to 25 degrees Celsius, during examination?", "Is there a bone present with a slightly alkaline pH, typically between 7.2 and 7.4?", "Does the image show a structure with moderate porosity, featuring cancellous bone between compact layers?", "Can you identify a surface area within the cranial vault estimated to be about 800 to 900 square centimeters in adults?"], "relational": ["Does the image show anatomical structures such as the brain or its protective membranes exposed?", "Can you identify separated cranial bones like the frontal, parietal, temporal, or occipital bones?", "Is there visual evidence of membranes such as dura mater, arachnoid mater, or pia mater?", "Does the image reveal regions of the brain like the cerebral cortex, cerebellum, or brainstem?", "Are cranial cavities such as the anterior, middle, or posterior cranial fossae visible?", "Can you see blood vessels like the middle meningeal artery, superior sagittal sinus, or cerebral veins?", "Is there direct exposure of the meninges that cover and protect the brain?", "Are adjacent facial or cranial structures such as the orbits, nasal cavity, zygomatic bones, or mandible present near the exposed area?", "Does the image show anatomical layers traversed, including the scalp, periosteum, skull bones, and meninges?", "Are parts of the nervous system such as the cerebrum, cerebellum, cranial nerves, or brainstem accessible in the image?"], "contexual_behavior": ["Does the image show evidence of cranial exposure that could increase the risk of brain infection from external pathogens?", "Is there a visible breach in the protective barriers of the head, such as the skull and meninges?", "Can you identify a situation where the regulation of intracranial pressure might be disrupted due to loss of the cranial vault's rigidity?", "Is there a region where the brain appears less protected against mechanical shocks because bony structures are missing or compromised?", "Does the image suggest possible leakage of cerebrospinal fluid due to disruption of the dura mater or other meningeal layers?", "Is there any indication of exposed vascular structures that could increase the risk of bleeding or impaired hemostasis?", "Can you see an area where the brain is directly vulnerable to environmental toxins due to loss of natural barriers?", "Does the image reveal a defect that could lead to abnormal heat loss or disrupted thermoregulation of brain tissue?", "Is there evidence that the brain's metabolic stability or homeostasis might be affected by exposure to the external environment?", "Can you identify features suggesting that the immune response within the cranial cavity could be altered due to a barrier breach?", "Does the image show a scenario where physiological regulation and homeostasis might be impaired during a surgical procedure due to loss of protective barriers?", "Is there visible exposure of blood vessels that could increase the risk of hemorrhage during trauma?", "Can you see signs that the effectiveness of the blood-brain barrier may be reduced due to structural disruption?", "Does the image suggest changes in cerebral blood flow dynamics as a result of altered intracranial pressure or loss of cranial enclosure?", "Is there evidence that the brain's defense against pathogens could be impaired during an open neurosurgical procedure because natural barriers are bypassed?"], "functions": ["Does the image show a situation where intracranial contents are directly exposed?", "Is there evidence of a loss of the protective barrier that normally surrounds the brain?", "Can you identify a scenario where the brain appears more vulnerable to external injury?", "Does the image suggest disruption of homeostatic pressure maintenance within the cranial cavity?", "Is there a visible indication that immune defense mechanisms for the brain might be compromised?", "Can you see signs that the regulation of intracranial pressure could be impaired due to the absence of a rigid enclosure?", "Does the image depict a context where direct access to intracranial structures for surgical intervention is possible?", "Is there visual evidence of instruments or visualization of brain tissue that would enable precise manipulation?", "Can you identify features that indicate an increased risk of trauma or infection to neural tissue?", "Does the image suggest the possibility of cerebrospinal fluid leakage or instability in pressure that would not occur with an intact cranium?", "Is there a scenario where the risk of central nervous system infection appears elevated due to loss of a protective barrier?", "Can you see signs that the brain\u2019s ability to buffer mechanical injury or maintain physiological stability is reduced?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a cell present that contains large, coarse granules?", "Is there a cell in the image whose density would be expected to be between 0 and 100 per microliter of peripheral blood?", "Can you see a cell with a volume in the range of 120 to 160 femtoliters?"], "relational": ["Is there a cell visible that circulates within the circulatory system and participates in immune surveillance?", "Is there a structure present in blood or connective tissue that could be involved in immune responses?", "Does the image include a structure that interacts with blood vessels or endothelial cells during inflammation?"], "contexual_behavior": [], "functions": ["Is there a cell present that contributes to immune defense by attracting or activating other immune cells?", "Can you see a cell that might undergo degranulation in response to immunoglobulin E (IgE) binding?", "Can you identify a structure that participates in immune regulation by releasing mediators?"]}}, "image": {"yes_questions": {"contexual_properties": ["Does the image contain areas where features are difficult to distinguish due to reduced clarity, possibly from loss of focus or motion?", "Can you observe regions where the difference between light and dark areas is minimal, making structures hard to see?", "Is there evidence of altered proportions of primary colors, suggesting a change in color balance or white balance?", "Are there parts of the image where individual pixels are visible, indicating insufficient resolution for the display size?", "Do you notice random variations in brightness or color that could indicate increased noise, perhaps from high sensor sensitivity or low light?", "Is there a loss of fine detail that might be due to decreased pixel density or overall resolution?", "Are there areas that appear excessively bright, with loss of detail, suggesting overexposure?", "Does the image contain regions that are unusually dark, with lost detail, possibly due to underexposure?", "Can you see any unwanted visual elements or irregularities that might be artifacts from technical limitations or processing errors?", "Are there places where edges and fine details are less defined, indicating a loss of sharpness?", "Is there any visible alteration in geometric proportions, such as bending or stretching, that could be due to distortion or lens aberration?", "Do you observe regions where the overall luminance is abnormally high or low, suggesting abnormal brightness?", "Are there areas where the intensity of colors appears unusually high or low, indicating altered saturation?", "Can you spot repetitive or unexpected patterns that might result from technical faults or interference?", "Are there shadows present in locations that do not correspond to the expected direction of illumination?", "Is there a noticeable loss of fine structures or details, possibly due to compression, low resolution, or blurring?", "Does the image have a coarse or grainy texture, especially in low-light areas, indicating high noise levels?", "Are there regions where the colors appear reversed, as in a negative image, possibly due to processing errors?", "Do you see areas where the difference between light and dark is exaggerated, making features more pronounced than usual?", "Are there unexpected spots or marks present, which could be due to sensor defects, dust, or artifacts?"], "properties": ["Can you identify an object whose resolution is defined by the number of pixels along its width and height?", "Is there an entity present whose file size would depend on its resolution, color depth, and compression?", "Does the scene include something characterized by a color depth such as 8-bit or 24-bit?", "Can you find an object with an aspect ratio like 4:3 or 16:9?", "Is there a structure whose width in pixels could be specified as 800, 1920, or 3840?", "Can you see something whose height in pixels might be 600, 1080, or 2160?", "Is there an entity that could be stored in formats such as JPEG, PNG, or TIFF?", "Can you identify an object with a bit depth per channel of 8 bits, 12 bits, or 16 bits?", "Is there something whose compression ratio might range from 2:1 to 20:1 depending on its format?", "Can you observe an entity whose average brightness level could be measured on a scale from 0 (black) to 255 (white)?", "Does the scene include something whose contrast level is defined by the difference between its darkest and brightest areas?", "Is there an object whose dynamic range could be expressed in stops or decibels?", "Can you find something with a pixel density measured in dots per inch, such as 72, 150, or 300 DPI?", "Is there an entity that uses a color space like sRGB, Adobe RGB, or CMYK?", "Can you see an object whose noise level could be quantified by signal-to-noise ratio or noise variance?"], "relational": ["Does the image display any structures that could be classified as bones or muscles?", "Can you identify features belonging to the skeletal or cardiovascular systems?", "Is there evidence of anatomical regions such as the thorax or abdomen in the image?", "Does the image show tissues like connective or nervous tissue?", "Can you observe spatial orientation or continuity between anatomical structures?", "Are there cells visible that resemble neurons or adipocytes?", "Does the image include structures adjacent to major blood vessels or ligaments?", "Can you determine if the image is oriented along the sagittal or transverse plane?", "Is there a visible organ such as the heart or kidneys in the image?", "Can you identify anatomical features at the tissue or cellular level?", "Does the image show proximity or overlap between neighboring organs?", "Are muscle tissue and epithelial tissue both present in the image?", "Can you see anatomical relationships that suggest the presence of surrounding tissues?", "Is the head or limbs region represented in the image?", "Does the image capture multiple hierarchical levels, such as both organs and tissues?"], "contexual_behavior": ["Does the image show any signs of reduced clarity or sharpness that could compromise diagnostic interpretation?", "Are there visible artifacts suggesting patient movement that might obscure anatomical details?", "Can you identify the use of contrast agents enhancing the visibility of specific tissues or lesions?", "Does the image appear to have been acquired using advanced techniques such as high-resolution MRI or PET, potentially improving sensitivity for disease detection?", "Is there evidence of low resolution that could limit the detection of subtle anatomical changes important for disease monitoring?", "Does the image suggest challenges in clarity or depth that might be encountered in obese patients during image-guided interventions?", "Can you determine which imaging modality was used, and does it provide unique contrast for differentiating tissue types?", "Is there evidence of 3D reconstruction that enhances spatial orientation and anatomical detail for surgical planning?", "Does the image quality suggest a high or low signal-to-noise ratio, potentially affecting the detection of small structures such as microcalcifications?", "Are there features in the image that highlight metabolic or physiological activity, aiding in tumor localization?", "Is there anatomical overlap present that could obscure regions of interest and compromise diagnostic function?", "Does the image appear to be part of a screening program where patient age or risk factors might influence disease detectability?", "Can you observe the effects of image enhancement processing, such as increased contrast or reduced artifacts, that might improve interpretation?", "Is there evidence of metallic implants causing artifacts that could obscure underlying tissues and hinder early disease detection?", "Does the image include dynamic contrast features that enable visualization of blood flow or vessel patency for vascular assessment?", "Are there motion artifacts present that could reduce the reliability of image-based measurements?", "Can you identify the fusion of information from multiple imaging modalities that might improve diagnostic function?", "Is anatomical visualization sufficient to guide a biopsy, or does poor visualization make target localization difficult?", "Does the image suggest it is being used for therapy monitoring during rapid disease progression, possibly requiring advanced or frequent imaging?", "Are there indications that specific radiotracers were used to enhance the detection of inflammation?"], "functions": ["Does the image provide visualization of internal anatomical structures?", "Can you identify any documentation of clinical findings within the image?", "Is there evidence in the image that could support clinical decision-making?", "Does the image reveal any pathological changes or abnormal findings?", "Can you use the image to aid in disease diagnosis by identifying abnormalities?", "Is there information in the image that could be used to monitor disease progression over time?", "Does the image allow for serial comparison to assess changes in anatomy or function?", "Can the image be used to support treatment planning by localizing lesions or mapping anatomy?", "Is there anatomical detail in the image that would help in targeting areas for intervention?", "Does the image provide real-time visualization or navigation of anatomical landmarks for surgical guidance?", "Can you use the image to detect anatomical abnormalities by assessing structure or function?", "Is there evidence in the image that could be used for organ function assessment, such as functional imaging features?", "Does the image contain information relevant to physiological evaluation of an organ?", "Can the image be used for disease screening or early detection of asymptomatic conditions?", "Is there visual evidence in the image that could facilitate preventive imaging?", "Does the image allow for assessment of therapy response by comparing pre- and post-treatment findings?", "Can you use the image to monitor treatment outcomes or evaluate changes in disease status?", "Is there information in the image that could facilitate image-guided minimally invasive procedures?", "Does the image provide visualization that would assist in procedural navigation during interventions?"]}, "no_questions": {"contexual_properties": ["Does the palate appear morphologically normal, with no interruption or gap present?", "Does the image show a face where the normal opening between the eyelids is missing or closed?", "Is there a lack of separation between the eyelids, possibly due to agenesis or congenital anomaly?"], "properties": ["Is there evidence of both eyelid tissue deficiency and a cleft in the palatal region?", "Does the image show a region where the normal eyelid opening is missing?", "Are there signs of feeding difficulties or speech impairment that could be related to anatomical defects in the eyelid and palate?"], "relational": ["Are the conjunctiva and eyelashes present without signs of abnormal clefts?", "Does the connective tissue and conjunctival epithelium appear unbroken in the eyelid region?", "Is there an absence of discontinuity in the hard or soft palate regions?"], "contexual_behavior": ["Does the image suggest a lower risk of speech or language delays commonly linked to the presence of a cleft palate?", "Does the image imply that surgical intervention for palate repair in early childhood is unlikely to be necessary?", "Can you identify features indicating preserved nasal airflow and normal breathing patterns, with no abnormal connection between the oral and nasal cavities?"], "functions": ["Is there evidence of typical facial development without disruptions to the eyelid or palate?", "Is there visual confirmation of eyelids capable of complete closure and movement?", "Are the eyelids and palate present in a way that would maintain physiological integrity and functional maintenance?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify evidence of a study that visualizes the gastrointestinal tract using X-ray imaging?", "Does the image show features consistent with the administration of a substance to outline the esophagus, stomach, or intestines on an X-ray?", "Is there a visible indication of a process designed to enhance the contrast of internal digestive structures for radiographic examination?"], "relational": ["Does the image provide information about the function or structure of the gastrointestinal tract?", "Is there evidence of a substance outlining the lumen of the gastrointestinal tract?", "Can you identify structures belonging to the digestive system that appear enhanced in the image?"], "contexual_behavior": ["Is there a visible indication of a substance enhancing the contrast of internal digestive structures on the image?", "Does the image depict a diagnostic procedure involving the use of a radiopaque contrast agent?", "Can you identify evidence of a study that visualizes the gastrointestinal tract using imaging techniques?"], "functions": ["Does the image provide information about motility or peristaltic activity in the digestive tract by showing the transit of a visible substance?", "Is there evidence of abnormalities such as masses, ulcers, or strictures within the digestive tract?", "Does the image show enhanced visualization of the gastrointestinal tract using a contrast agent?"]}}, "janiceps": {"yes_questions": {"contexual_properties": ["Does the image show evidence of asymmetrical head size during embryonic or fetal development?", "Can you identify abnormal cranial structures that might result from incomplete cranial division in the prenatal period?", "Is there a visible fusion of facial features suggestive of craniofacial abnormality during early gestation?", "Does the image display differences in skull composition, such as variable degrees of fusion or ossification during fetal growth?", "Can you observe variation in neural tissue development that could be influenced by the degree of cranial fusion in utero?", "Is there a detectable change in head circumference that might be identified by prenatal imaging due to partially fused heads?", "Does the image reveal altered bone density in the skull, possibly resulting from abnormal bone formation and fusion during embryonic development?", "Can you see abnormal skin coloration on the heads at birth that could indicate vascular anomalies?", "Is there evidence of tissue or organ duplication that might have occurred during organogenesis as a result of twinning?", "Does the image show changes in the size of shared organs that could be attributed to developmental constraints from conjoined anatomy?"], "properties": ["Does the image show an individual with a head size that appears larger than average due to craniofacial duplication?", "Can you identify a newborn whose weight seems higher than typical for singletons, possibly exceeding 4 kilograms?", "Is there a broad and rounded cranial shape suggestive of bifacial cranium or cranial widening?", "Does the image depict two distinct sets of facial features, each on opposite sides of the head?", "Can you observe evidence of partial brain duplication or fused cerebral hemispheres within the cranial region?", "Is the skin color of the neonate consistent with normal variation for their genetic background?", "Does the length of the newborn appear within the typical range of 45 to 55 centimeters?", "Are there four eyes visible, with two eyes present on each face?", "Can you see two mouths, each corresponding to a separate set of facial features?", "Are there four ears present, with two ears per face?", "Do the facial features appear to be arranged symmetrically on opposite sides of the head?", "Is there a single, centrally located neck supporting both sets of facial features?", "Can you identify duplicated facial bones or partially fused cranial vault bones in the head structure?", "Does the distance between the two faces correspond to the width of the shared cranium?", "Are the facial features arranged in a mirror-image pattern across the sagittal plane?"], "relational": ["Does the image show a single head with two complete faces oriented in opposite directions?", "Can you identify a structure where the cranium is fused but facial features such as eyes, noses, and mouths are duplicated?", "Is there evidence of two sets of orbits, nasal cavities, and mandibles present on one skull?", "Does the image contain duplicated cranial structures, such as two brains or two sets of upper respiratory organs, within a shared torso?", "Can you see a region where the frontal, temporal, or occipital areas of the head appear structurally altered due to facial duplication?", "Is there a visible connection between two faces by shared cranial bone and soft tissue?", "Does the image depict a form of conjoined twinning characterized by craniofacial duplication rather than fusion at the thorax or pelvis?", "Are there duplicated facial bones, such as maxillae and zygomatic bones, present on a single fused cranium?", "Can you observe two faces affecting the head, neck, and upper thorax regions in the image?", "Is there a structure in the image where organ systems in the torso appear shared, but cranial features are duplicated?"], "contexual_behavior": ["Does the image show an individual with two heads that might have difficulty coordinating movement or integrating sensory information?", "Can you identify signs of altered breathing patterns that could result from shared thoracic structures or malformed thoracic organs?", "Is there evidence of reduced cardiac efficiency, such as signs of physical stress, that could be related to duplicated or fused cardiovascular anatomy?", "Does the image depict abnormal feeding behavior, possibly due to both mouths attempting to feed at the same time or interference between oral structures?", "Can you observe features that might indicate difficulty in regulating body temperature, such as duplicated heads or increased surface area?", "Is there any indication of compromised locomotor function, such as impaired coordination between two heads and shared musculoskeletal structures?", "Does the image suggest problems with swallowing or airway protection that could arise from duplicated pharyngeal or laryngeal structures?", "Can you see signs of altered metabolic activity, such as increased tissue mass or duplicated organs, that might affect energy balance?", "Is there visual evidence of increased risk of infection, possibly due to shared or fused organ systems that could facilitate pathogen transmission?", "Does the image suggest a failure to coordinate sensory input between two heads, such as conflicting responses to external stimuli?"], "functions": ["Does the image show a developmental anomaly characterized by craniofacial duplication?", "Can you identify evidence of conjoined twinning involving two faces on a single head?", "Is there visual indication of duplication or fusion of cranial and neural structures?", "Does the image reveal abnormalities that could disrupt normal physiological processes in the head or brain?", "Can you observe features suggesting shared or duplicated brain, airway, or vascular systems?", "Is there evidence of structural fusion that might impair organ function?", "Does the image display abnormal vascular connections or duplications in the head and neck region?", "Can you identify signs of circulatory compromise or hemodynamic instability related to vascular anomalies?", "Is there visual evidence of two brains or partially fused neural tissue that could affect neural coordination?", "Does the image suggest impaired or uncoordinated neural control due to neural fusion or brain duplication?", "Can you observe abnormal airway anatomy, such as duplicated or obstructed respiratory passages?", "Is there indication of respiratory compromise or pulmonary dysfunction due to airway malformation?", "Does the image show features that could disrupt metabolic regulation, such as duplicated or fused hypothalamic regions?", "Can you identify signs of endocrine disruption or hypothalamic anomaly that might affect metabolic balance?", "Is there evidence of duplicated or fused sensory organs or neural pathways that could alter sensory integration?", "Does the image suggest abnormal perception or processing due to sensory duplication or neural integration deficit?", "Can you observe oral or pharyngeal malformations that might hinder effective swallowing or feeding?", "Is there visual indication of digestive impairment or feeding difficulty related to abnormal oral structures?", "Does the image reveal signs of disrupted central nervous system control over vital functions?", "Can you identify features that might lead to homeostatic instability, such as temperature, fluid, or metabolic imbalance?"]}, "no_questions": {"contexual_properties": ["Do you see changes in cell composition that could be linked to differentiation or microenvironmental influences?", "Is there evidence of cells changing in size, possibly indicating activation or differentiation processes?", "Can you observe enlarged cells that may be undergoing activation, senescence, or pathological stress?"], "properties": ["Do any cells exhibit a diploid chromosomal content, specifically 46 chromosomes?", "Are there cells that could have a lifespan of several weeks to a few months in vitro?", "Is there a population of cells with a higher proliferation rate than mature hepatocytes, possibly doubling every 24 to 48 hours?"], "relational": ["Is there evidence of cells that could give rise to hepatocytes or cholangiocytes?", "Is there a visible anatomical feature corresponding to periportal regions within the liver?", "Can you identify a region within the liver that contains specialized canals, such as the canals of Hering?"], "contexual_behavior": ["Does the image suggest enhanced tissue repair following partial removal of liver tissue, indicating activation of a regenerative cell population?", "Is there a decline in the ability to repopulate damaged liver tissue in an aging context, potentially due to cellular senescence?", "Is there a visible reduction in differentiation into hepatocytes in the context of chronic liver disease, possibly due to persistent inflammation?"], "functions": ["Can you identify structures that could contribute to liver regeneration by forming new hepatocytes or cholangiocytes after injury?", "Is there visual evidence of tissue regeneration or anti-fibrotic effects that might occur during chronic liver disease repair?", "Does the image display cells that appear activated, proliferating, or migrating toward areas of liver damage?"]}}, "foramina magna": {"yes_questions": {"contexual_properties": ["Does the image show an opening at the craniovertebral junction that appears enlarged, as might be seen in achondroplasia or basilar invagination?", "Is there evidence of narrowing at the base of the skull, suggestive of conditions like Chiari malformation or craniosynostosis?", "Can you identify a structure whose shape appears altered due to congenital anomalies, trauma, or bone disease?", "Is there abnormal bone growth near the cranial base, as might occur in osteopetrosis or Paget\u2019s disease?", "Does the image reveal irregular margins at the cranial opening, possibly due to chronic pressure, bone erosion, or neoplastic invasion?", "Is there a visible mass compressing the cranial opening, such as a meningioma or herniated brain tissue?", "Can you see an enlarged opening at the skull base, which could be associated with megalencephaly or hydrocephalus?", "Does the cranial base appear misshapen, potentially due to developmental disorders, trauma, or prior surgery?", "Is there an obstruction at the cranial opening caused by a lesion, cyst, or downward herniation of cerebellar tissue?", "Can you observe thinning of the bone surrounding the cranial opening, as might be seen in metabolic bone disease or osteoporosis?", "Is there evidence of bony spurs or outgrowths at the base of the skull, suggestive of diffuse idiopathic skeletal hyperostosis or degenerative changes?", "Does the image show signs of bone erosion at the cranial opening, possibly due to chronic inflammation, metastatic cancer, or infection?", "Is there a change in the position of the cranial opening relative to the skull base, as seen in basilar invagination or atlantoaxial dislocation?", "Can you identify calcification around the cranial opening, which might result from metabolic disorders, chronic inflammation, or trauma?", "Does the opening at the cranial base appear asymmetric, potentially due to congenital malformation, trauma, or unilateral bone disease?"], "properties": ["Is there an opening located at the base of the skull within the occipital bone?", "Can you identify a structure with an oval or elliptical shape near the skull base?", "Does the image show an aperture with a diameter close to 35 millimeters?", "Is there a feature whose area appears to be within the range of 700 to 900 square millimeters?", "Can you see an opening with a circumference of approximately 100 millimeters?", "Is there a structure with an average height of about 30 millimeters and width of around 27 millimeters?", "Does the image contain an opening oriented in an anteroposterior direction, sloping slightly forward?", "Can you identify a feature formed entirely by the occipital bone?", "Is there evidence of size variation in the opening that could be attributed to differences in age or developmental stage?"], "relational": ["Is there a large opening within the occipital bone visible in the image?", "Can you identify a structure located in the posterior cranial fossa of the skull?", "Does the image show an area where the medulla oblongata or spinal cord passes through?", "Is there a region where vertebral arteries or spinal accessory nerves might traverse?", "Can you see anatomical features adjacent to a large cranial opening, such as occipital condyles or the clivus?", "Is there a structure near the jugular tubercles in the posterior part of the skull?", "Does the image display a connection between the cranial cavity and the cervical spinal canal, starting with the atlas (C1 vertebra)?", "Is there evidence of ligaments such as the tectorial membrane or alar ligaments attaching near a major cranial opening?", "Can you identify an area where the anterior or posterior spinal arteries enter or exit the skull?", "Is there a visible relationship between the occipital bone and the passage of lower cranial nerves (IX\u2013XI)?"], "contexual_behavior": ["Does the image show evidence of an opening at the base of the skull where cerebrospinal fluid flow might be obstructed during increased intracranial pressure?", "Is there a region where downward displacement of brain tissue, such as the cerebellar tonsils, could impair neural transmission?", "Can you identify an area that might restrict the normal passage of the brainstem in the presence of congenital malformations like Chiari malformation or basilar invagination?", "Does the image reveal signs of vascular structures, such as vertebral arteries or veins, being compressed by swelling, hemorrhage, or bone displacement after trauma?", "Is there visual evidence of compromised protection for neural structures due to downward herniation of cerebellar tissue, as seen in Chiari malformation?", "Can you see abnormal displacement of cerebellar tissue through an opening at the base of the skull, possibly due to raised intracranial pressure?", "Does the image suggest changes in craniospinal communication following surgical procedures like decompressive craniectomy or decompression at the cranial base?", "Is there an indication of cerebrospinal fluid drainage being obstructed by herniated tissue or congenital narrowing, as might occur in hydrocephalus?", "Can you detect signs of bone erosion or weakening at the cranial base that could be caused by metastatic disease?", "Is there evidence of downward displacement of the brainstem, potentially resulting from acute brain swelling and increased intracranial pressure?"], "functions": ["Does the image show a large opening at the base of the skull that serves as a passageway for the medulla oblongata?", "Can you identify a structure that provides direct anatomical continuity between the brainstem and the spinal cord?", "Is there an opening visible that allows neural tissue and meninges to pass from the cranial cavity into the vertebral canal?", "Does the image contain a feature that permits the transition of motor and sensory neural tracts between the brain and spinal cord?", "Can you see an opening through which vertebral arteries and spinal arteries enter the cranial cavity to supply blood to the brain?", "Is there a structure at the cranial base that encases and protects the lower brainstem and upper spinal cord within the skull?", "Does the image show a region that enables the flow of cerebrospinal fluid between the cranial and spinal subarachnoid spaces?", "Can you identify a feature that contributes to cranial stability by connecting the skull to the vertebral column at the atlanto-occipital joint?", "Is there an opening that could serve as a conduit for pressure equalization between the cranial and spinal compartments, influencing intracranial pressure?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see a structure that originates from the heart and distributes oxygenated blood?", "Is there a major blood vessel visible in the neck, thorax, abdomen, or limbs?", "Does the image show a vessel adjacent to nerves, veins, or lymphatic vessels?"], "contexual_behavior": ["Does the image show a structure that could have reduced oxygen transport capacity in hypoxic conditions?", "Can you identify an object that would constrict more in response to cold exposure due to increased sympathetic activation?", "Is there an object that could alter its blood flow pattern during stress because of sympathetic nervous system activation?"], "functions": ["Can you identify a structure whose walls contain smooth muscle for controlling blood flow and resistance?", "Is there a structure that indirectly supports waste removal by delivering blood to sites of exchange?", "Is there an object involved in thermoregulation by altering blood flow to the skin?"]}}, "skull": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with an oval or rounded shape and a slightly elongated anteroposterior axis?", "Can you identify an object that appears off-white or pale ivory due to mineralized bone tissue?", "Is there a structure present that could measure approximately 22 cm in length, 17 cm in width, and 14 cm in height?", "Does the image contain an object whose thickness varies between 4 and 8 millimeters depending on the region?", "Can you see a structure that might weigh between 1.3 and 1.5 kilograms in adults?", "Is there an object composed primarily of compact and spongy bone, collagen fibers, hydroxyapatite, and water?", "Does the image include a structure made up of 22 bones, with both cranial and facial components?", "Can you identify an object with a moderate porosity, especially in regions containing spongy bone?", "Is there a structure whose surface appears mostly smooth but with some roughened areas for muscle attachment?", "Does the image show an object with a circumference of about 55 to 58 centimeters?", "Can you see a structure that might have a bone density ranging from 1.5 to 2.0 g/cm\u00b3?", "Is there an object whose water content is approximately 10% by weight?", "Does the image contain a structure with a mineral content mainly consisting of hydroxyapatite, accounting for about 65% of its dry weight?", "Can you identify an object with a calcium concentration of about 20\u201325% and a phosphorus concentration of roughly 10\u201312% of its total weight?", "Is there a structure with a collagen content of about 20\u201325% of its organic matrix?", "Does the image show an object with a typical hardness of around 5 on the Mohs scale?", "Can you see a structure whose cranial cavity volume could be approximately 1350 to 1500 milliliters?"], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify any bones such as the frontal, parietal, or temporal bones?", "Is there a region visible that could correspond to the cranium or facial skeleton?", "Does the image display features like the calvaria or cranial base?", "Can you see any joints such as cranial sutures or the temporomandibular joint?", "Is there evidence of cavities like the cranial, nasal, or orbital cavities?", "Does the image include a structure that protects the brain or eyes?", "Can you identify an articulation point with the vertebral column, such as the foramen magnum?", "Is there a visible area where muscles like the temporalis or masseter might attach?", "Can you see any foramina, such as the optic canal or jugular foramen?", "Are there distinguishing features such as multiple cavities or complex articulations present?", "Does the image show a structure involved in protecting the inner ear or nasal passages?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides protection for the brain?", "Can you identify a rigid bony cavity that encapsulates neural tissue?", "Does the image show a framework that supports sensory organs such as the eyes or ears?", "Is there a visible structure forming orbital or nasal cavities?", "Can you see attachment points for muscles involved in chewing?", "Does the image include features like the mandible or maxilla that enable mastication?", "Is there a bony framework shaping the forehead, cheeks, or jaw?", "Can you identify surfaces or ridges for the attachment of facial muscles responsible for expression?", "Does the image show structures forming the oral or nasal cavities, which facilitate speech resonance?", "Is there evidence of air-filled cavities that could contribute to sound resonance?", "Can you see anatomical features that protect the entrances to the respiratory or digestive tracts?", "Is there a structure maintaining a closed cavity that could help regulate intracranial pressure?"]}, "no_questions": {"contexual_properties": ["Can you identify a case where each individual has their own brainstem visible in the image?", "Does the image show two individuals who are physically connected but have distinct lower brain structures?", "Does the image depict two bodies sharing some anatomy but maintaining separate neural connections at the base of the brain?"], "properties": ["Can you see anatomical features that would support separate arterial and venous systems for each brain, with only minor shared vessels at points of fusion?", "Does the image suggest that cerebral oxygenation levels in each brain could be within the normal range of 60\u201370%?", "Is there evidence of partially or fully separated skulls, suggesting individual cranial cavities?"], "relational": ["Does the image depict two brainstems, each associated with its own cerebellum and spinal cord?", "Is there evidence of two separate sets of vascular structures, such as basilar or vertebral arteries, supplying neural tissue?", "Are there musculoskeletal features indicating partial fusion or separation, such as shared vertebrae or scalp?"], "contexual_behavior": ["Can you identify a pair of bodies where the lower brain regions are distinct for each individual?", "Does the image depict twins with independent connections between their brains and spinal cords?", "Is there evidence of two separate neural structures at the base of the brain in the image?"], "functions": ["Can you see signs that each individual possesses their own consciousness and awareness?", "Does the image show two individuals who each appear to maintain their own vital signs such as breathing and heart rate?", "Does the image suggest that autonomic processes like digestion or thermoregulation are independently regulated in each person?"]}}, "cephalothoracopagus": {"yes_questions": {"contexual_properties": ["Does the image show two individuals with noticeable asymmetry in size that could suggest unequal distribution of shared organs or tissues?", "Is there evidence of abnormal skin color at a region where two bodies are joined, possibly indicating compromised blood flow or vascular anomalies?", "Can you observe differences in organ composition or arrangement between the two individuals, suggesting incomplete duplication or fusion of vital organs?", "Is there an increased overall body weight or bulkiness that might be due to accumulation of shared tissues or fluid retention at a junction?", "Does the image reveal abnormal tissue structures or irregularities at the area where the two bodies are fused, possibly resulting from disrupted tissue differentiation?", "Are there visible changes in the size or shape of the head or thorax between the two individuals, indicating disproportionate growth or malformation of cranial or thoracic structures?", "Can you identify altered or abnormal vascular patterns at the site where the two bodies are joined, which might be consistent with vascular malformations?", "Is there localized swelling or puffiness at the fusion site that could be due to fluid accumulation or lymphatic obstruction?", "Does the image show abnormal bone formation, such as fused or malformed bones, at the area where the two bodies are connected?", "Are there visible signs that suggest differences in organ function or metabolic activity between the two individuals, such as asymmetry in measurable features?", "Can you observe any fluid accumulation at the junction of the two bodies, possibly indicating impaired drainage or increased vascular permeability?", "Is there a change in tissue density or texture at the area of union, which could be due to abnormal tissue composition or fibrosis?", "Does the fusion area display abnormal pigmentation or localized skin changes that might be related to vascular or developmental anomalies?", "Are there differences in limb size between the two individuals, suggesting disproportionate limb growth due to unequal nutrient or blood supply?", "Can you detect abnormal or unequal growth rates in either individual, potentially resulting from differential organ sharing or metabolic imbalance?"], "properties": ["Does the image show an individual whose overall size is similar to that of a term newborn?", "Can you identify a body with two heads that appear fused together and share a single upper torso?", "Is there evidence of two faces or crania that are joined at both the head and chest regions?", "Does the image display a configuration where the upper organs, such as the heart or lungs, might be shared between two heads?", "Are there four limbs visible, with two upper and two lower extremities, or any signs of limb duplication?", "Do the heads appear side by side or partially merged at the cranial region?", "Is there a single, broad chest cavity that could contain shared thoracic organs?", "Can you observe features suggesting a single heart, or possibly two hearts, within a shared thorax?", "Does the vertebral column appear partially fused in the neck and chest areas, with possible duplication below the chest?", "Are the head circumferences of each head within the range typical for newborns, approximately 32 to 38 centimeters?", "Is the skin color consistent with that of a non-conjoined newborn of the same ethnicity?", "Do the facial features appear duplicated, partially merged, or show midline fusion or asymmetry?", "Is the overall length of the body between 45 and 55 centimeters, similar to a term neonate?", "Can you see evidence of fused skulls with possible duplication of brain or facial structures?", "Are there signs that the lower organs might be duplicated while the upper organs are shared?"], "relational": ["Does the image show two individuals with their head and upper chest regions fused together?", "Can you identify a case where the skulls and cervical spines of two bodies are connected?", "Is there evidence of a shared cranial vault or merged facial bones between two individuals?", "Does the image display a fusion that extends from the top of the skull to the upper abdomen?", "Can you see two bodies with a contiguous cranial and thoracic region?", "Is there a visible merging of the neck and upper thorax between two individuals?", "Does the image suggest the presence of shared organ systems such as the upper respiratory, cardiovascular, or digestive systems between two bodies?", "Can you identify a structure where the brain, heart, or liver appears to be joined between two individuals?", "Is there a case of shared or interconnected circulatory systems, such as a common heart or major vessels, visible in the image?", "Does the image show merged cranial or thoracic cavities between two individuals?", "Can you see evidence of connected cerebral hemispheres, brainstem, or cranial nerves between two bodies?", "Is there a fusion involving the nasal cavities, pharynx, larynx, trachea, or upper lungs of two individuals?", "Does the image display a joining of the upper gastrointestinal tract, such as the esophagus, between two bodies?", "Can you observe anatomical boundaries of fusion that include both the cranial and thoracic regions?", "Is there a visible connection of the upper thoracic skeleton, including the thoracic cage, between two individuals?"], "contexual_behavior": ["Does the image show individuals with shared thoracic structures that could limit lung capacity or airway patency?", "Is there evidence of a shared cardiovascular system that might struggle to compensate during physiological stress?", "Can you identify features suggesting incomplete or mismatched neural pathways between conjoined individuals?", "Does the image depict overlapping hepatic or pancreatic tissues that could compromise metabolic processing?", "Is there a visible fusion or abnormality in the gastrointestinal tracts that might affect feeding coordination?", "Can you see anatomical features indicating disrupted thermoregulation due to shared or abnormal hypothalamic control?", "Is there evidence of merged or cross-reactive immune systems that could alter immune responses compared to single individuals?", "Does the image suggest shared or underdeveloped renal or hepatic systems that might decrease waste elimination efficiency?", "Can you identify features that could compromise immune cell production or distribution, affecting infection or inflammation responses?", "Is there anatomical evidence of fused or dysregulated glands, such as the thyroid or pituitary, that might impact endocrine function?", "Does the image show shared hearts or vessels that could impair circulation during physical exertion?", "Is there evidence that shared respiratory or circulatory systems might limit oxygen delivery under hypoxic conditions?", "Can you see signs that shared organ systems could make it difficult to maintain homeostasis during illness?", "Is there anatomical indication of incomplete or conflicting neural circuits that might decrease neural control of movement in response to stress?", "Does the image suggest functional limitations of shared organs that could impair growth or development for both individuals?"], "functions": ["Does the image show individuals with evidence of fused organs or complex anatomical connections?", "Can you identify any signs of compromised organ function or physiological complexity in the depicted structures?", "Is there visual evidence of shared organs that might be functioning under abnormal conditions?", "Does the image suggest an increased risk of organ failure due to impaired efficiency of shared anatomical structures?", "Can you observe features indicating shared or fused hearts or blood vessels, potentially leading to abnormal blood flow?", "Is there any indication of hemodynamic instability or vascular fusion in the circulatory system?", "Does the image show shared or malformed airways or lungs that could compromise respiratory processes?", "Can you see signs of reduced respiratory efficiency or potential for respiratory distress?", "Is there visual evidence of fused or duplicated neural structures that might affect coordination or neural control?", "Do the depicted individuals show features that could lead to conflicting neural signals or coordination challenges?", "Can you identify shared livers or endocrine organs that might disrupt metabolic regulation or homeostasis?", "Is there any indication of difficulties in maintaining metabolic balance or signs of endocrine disruption?", "Does the image suggest shared gastrointestinal tracts or vascular systems that could affect nutrient absorption and distribution?", "Can you observe features that might lead to unequal nutrient delivery or risk of malnutrition?", "Is there evidence of shared or malformed excretory organs that could impair waste elimination?", "Does the image suggest a risk of metabolic waste accumulation or renal dysfunction?", "Can you see fused skeletal or muscular systems that might restrict movement or motor control?", "Is there visual evidence of limited mobility or motor impairment due to anatomical fusion?", "Do the depicted individuals show signs of shared lymphatic tissues or atypical immune system features?", "Is there any indication of altered immune responses or exposure to different antigens in the shared anatomy?"]}, "no_questions": {"contexual_properties": ["Does the image reveal new layers or stratification on the surface of an existing clot, suggesting recurrent thrombosis?", "Is there evidence of fragmentation or small pieces within a venous structure, possibly resulting from mechanical disruption, thrombolytic therapy, or spontaneous embolization?", "Does the image show features such as organization, recanalization, or calcification that would indicate chronicity of a venous lesion?"], "properties": ["Is there a structure in a deep vein that might show signs of increased organization, suggesting it has been present for some time?", "Is there evidence of a mass in a deep vein that is likely composed primarily of fibrin and red blood cells?", "Is there a mass within a deep vein that could have a high protein content due to the presence of fibrin and plasma proteins?"], "relational": ["Does the image contain a finding that could affect the systemic venous circulation?", "Does the image show evidence of an obstruction within the deep venous system of the lower limb?", "Is there a visible abnormality within the femoral, popliteal, iliac, or tibial veins?"], "contexual_behavior": ["Can you identify a region where venous return might be severely impaired due to a sizable or occlusive formation?", "Is there evidence of persistent venous obstruction or valve damage that could contribute to chronic venous insufficiency?", "Is there evidence of a structure within a major vein, such as the femoral or iliac, that appears large or causes significant blockage of blood flow?"], "functions": ["Are there chronic changes present, such as persistent edema or skin alterations, that could be associated with chronic venous insufficiency?", "Does the image reveal swelling of the limb that could be attributed to increased hydrostatic pressure or fluid accumulation?", "Does the image show evidence of venous obstruction or reduced blood flow in a deep vein of the lower limb?"]}}, "conjoined twins": {"yes_questions": {"contexual_properties": ["Can you identify two individuals in the image who display differences in organ size that might suggest unequal blood supply or asymmetric development?", "Is there evidence of unequal body weights between two connected individuals, possibly indicating growth disparity or metabolic differences?", "Do you observe asymmetrical limb lengths that could be due to uneven musculoskeletal development or differential limb usage?", "Is there abnormal skin coloration present in one of the connected bodies that might indicate vascular anomalies or compromised circulation?", "Can you see a difference in head circumference between the two individuals, which could suggest unequal cranial development or hydrocephalus?", "Are there visible signs that suggest variations in blood composition, such as differences in skin tone or vascular patterns, possibly due to shared or separate circulation?", "Does the image show a shared organ or structure that appears incompletely divided or functionally partitioned between two bodies?", "Is there swelling at the connection site that could be explained by lymphatic obstruction or localized inflammation?", "Can you observe changes in tissue density at the junction, such as areas that look unusually firm or fibrotic?", "Are there visible differences in features that might reflect unequal hormone levels, such as variations in secondary sexual characteristics or growth patterns?", "Is there evidence of abnormal fluid accumulation, such as localized edema, that could be due to impaired lymphatic drainage or cardiac dysfunction in one or both individuals?", "Do you notice differences in bone structure or density, possibly reflecting unequal mechanical loading or nutritional disparities?", "Is there a visible difference in body temperature distribution, such as one individual appearing flushed or pale compared to the other, suggesting altered blood flow or metabolism?", "Can you see differences in muscle mass between the two bodies, which might indicate variations in physical activity or nutritional support?", "Is there a change in skin texture at the junction, such as areas of scarring or chronic friction?", "Are there signs of differing blood pressure, such as one individual having more prominent veins or pallor, that could suggest partially shared or independent cardiovascular systems?", "Do you observe abnormal tissue growth at the site of connection, such as masses or irregularities that could indicate chronic irritation or neoplastic changes?", "Is there visual evidence of changes in organ composition, such as differences in tissue color or consistency, possibly due to unequal metabolic exchange?", "Can you identify differences in apparent metabolic rates, such as one individual appearing more energetic or with different body composition?", "Is there discoloration at the junction area, such as bluish or darkened skin, that might result from impaired venous return, local hypoxia, or chronic pressure?"], "properties": ["Does the image show two anatomically connected bodies with evidence of physical fusion?", "Can you identify a case where there is thoracic, abdominal, pelvic, or cranial fusion between two individuals?", "Is there visual evidence of organ sharing, such as a single liver or heart serving both bodies?", "Does the image suggest the presence of shared gastrointestinal or genitourinary organs between two connected individuals?", "Can you observe asymmetry or partial symmetry in the distribution of body parts between the two connected bodies?", "Is there a noticeable difference in limb length, torso size, or head circumference between the two fused individuals?", "Does the total number of limbs visible range from four to eight, suggesting variable limb count due to physical fusion?", "Can you see any signs of fused skulls or shared facial structures, particularly in the cranial region?", "Is there evidence of shared vascular structures, such as hepatic veins or cardiac vessels, between the two bodies?", "Does the image depict two neonates with normal skin color for their genetic background?", "Can you estimate if the combined birth weight of the two connected individuals falls within the low birth weight range of 2.5 to 4.5 kilograms?", "Is there any indication that the gestational age at birth is preterm, around 34 to 36 weeks?", "Does the head circumference of either individual appear to be within the normal neonatal range of 33 to 36 centimeters?", "Can you infer from the image whether the two connected individuals are genetically identical?"], "relational": ["Does the image show two individuals with a visible connection at regions such as the thorax, abdomen, pelvis, or head?", "Can you identify any shared anatomical structures, such as a single liver or heart, between two bodies?", "Is there evidence of fusion involving organ systems like the digestive or circulatory systems?", "Do you observe tissues such as skin, muscle, or bone forming a bridge between two individuals?", "Are there skeletal elements, such as the sternum, vertebrae, pelvic bones, or skull, that appear joined between two bodies?", "Does the image suggest the presence of shared blood vessels or cross-circulation between two individuals?", "Can you see duplication or sharing of organs like the intestines, kidneys, or bladder between two connected bodies?", "Is there a visible fusion along anatomical planes such as sagittal, transverse, or coronal between two individuals?", "Do the thoracic, abdominal, pelvic, or cranial cavities appear to be connected between two bodies in the image?", "Are there points of attachment at the chest, abdomen, pelvis, head, or spine linking two individuals?"], "contexual_behavior": ["Does the image show individuals whose anatomy suggests that vital organs might be shared or incompletely separated, potentially leading to compromised physiological processes?", "Can you identify evidence of anatomical fusion that could restrict independent movement or joint articulation?", "Is there visual indication of extensive vascular connections that might result in unbalanced circulation under physical or hemodynamic stress?", "Does the image suggest the possibility of altered metabolic rates due to unequal tissue distribution or shared organs?", "Can you see features that imply a shared digestive tract, which could affect nutrient absorption?", "Is there evidence of shared excretory organs, such as kidneys or bladder, that might impair waste elimination for both individuals?", "Does the anatomy depicted suggest that heat dissipation or retention could be affected by shared body mass or surface area, potentially altering thermoregulation?", "Is there a visible indication that total lung capacity or ventilation might be reduced due to shared lungs?", "Can you identify a situation where a single heart might be responsible for the circulatory demands of two bodies, possibly leading to insufficient cardiac output?", "Does the image suggest the presence of shared circulation, which could increase susceptibility to infection by facilitating pathogen transfer?", "Is there anatomical evidence that could indicate a slower healing process after surgery due to shared vascular supply or increased physiological stress?", "Can you see signs that suggest shared endocrine organs, which might disrupt hormonal regulation?", "Does the depicted anatomy imply that a shared nervous system could alter pain perception or sensory processing?", "Is there visual evidence that the risk of organ failure could be increased during critical illness due to shared organs?", "Can you identify features that might indicate a difference in growth rate compared to non-fused individuals, possibly due to metabolic or anatomical constraints?", "Does the image suggest that compensation for blood loss could be affected by the extent of shared vascular connections?", "Is there anatomical evidence that the function of shared organs might deteriorate with age due to cumulative physiological stress?", "Can you see signs that drug metabolism could be altered if a single liver is shared between two individuals?", "Does the depicted anatomy suggest that immune response or pathogen exposure might differ between the individuals due to shared immune organs or cross-circulation?", "Is there evidence that the stress response during illness could be affected by shared physiological systems or organs?"], "functions": ["Does the image show individuals who might experience challenges in maintaining homeostasis due to interconnected anatomical structures?", "Can you identify a case where organ function could be compromised by the fusion of two bodies?", "Is there evidence of anatomical fusion that could require physiological coordination between two individuals?", "Does the image suggest the possibility of shared circulatory systems, which might lead to mixed blood flow or cross-circulation complications?", "Can you see features indicating that nutrient distribution or oxygen delivery might be affected by shared vascular connections?", "Is there a scenario where metabolic processes or drug metabolism could be complicated by the presence of shared organs?", "Does the image suggest that waste elimination might be challenging due to altered anatomical pathways?", "Can you identify overlapping tissues or organs that could result in increased susceptibility to infection or autoimmune reactions?", "Is there visual evidence of duplicated organs that might provide functional redundancy or independence?", "Does the image show anatomical features that would require coordinated regulation of shared organs?", "Can you see signs of integrated feedback mechanisms or compensatory physiological adjustments maintaining balance between two individuals?", "Is there evidence of adaptive anatomical connections that could enable survival with shared vital organs?", "Does the image suggest the need for complex motor coordination or voluntary cooperation between two bodies?", "Can you identify features indicating shared or separate nervous systems that might affect sensory perception or motor control?", "Is there visual evidence of altered digestive flow or gastrointestinal sharing that could impact nutrient absorption or risk of obstruction?", "Does the image suggest the presence of integrated systemic regulation or compensatory organ function to maintain physiological balance?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a sample that looks firm and rubbery in texture?", "Does the image contain a sample that might have a refractive index between 1.45 and 1.50?", "Is there a specimen that could have less than 10% lipid content due to processing?"], "relational": ["Does the image show a sample containing substructures like blood vessels, glands, or extracellular matrix?", "Is there a specimen that appears to be part of a larger anatomical structure, such as an organ or tissue block?", "Is there a sample that could represent an organ commonly studied in histology, such as the liver, kidney, lung, or brain?"], "contexual_behavior": ["Can you observe any loss of cellular structure that might indicate incomplete or suboptimal preservation?", "Is there a region where enzyme activity appears absent, possibly due to denaturation or disruption of protein active sites by fixatives?", "Can you identify tissue that appears less suitable for molecular analysis, perhaps due to excessive cross-linking or fragmentation?"], "functions": ["Does the specimen appear compatible with molecular analysis techniques, such as PCR or sequencing, due to stabilized nucleic acids and proteins?", "Is there a sample that retains diagnostic features necessary for histological evaluation in pathology?", "Does the image show a biological sample that appears stabilized for research or experimental analysis?"]}}}
[ { "answer": "due to terminal alcoholic cirrhosis with shock and typical facial appearance of edema due to generalized capillary permeability increase or shock", "extracted_concepts": [ "edema", "terminal alcoholic cirrhosis", "typical facial appearance of edema", "jaundice", "generalized capillary permeability increase", "shock" ], "question": "why does this image show jaundice?" }, { "answer": "due generalized capillary permeability increase or", "extracted_concepts": [ "edema", "terminal alcoholic cirrhosis", "typical facial appearance of edema", "jaundice", "generalized capillary permeability increase", "shock" ], "question": "why does this image show jaundice due to terminal alcoholic cirrhosis with shock and typical facial appearance of edema?" }, { "answer": "jaundice due to terminal alcoholic cirrhosis with shock and typical facial appearance of edema due to generalized capillary permeability increase or shock", "extracted_concepts": [ "edema", "terminal alcoholic cirrhosis", "typical facial appearance of edema", "jaundice", "generalized capillary permeability increase", "shock" ], "question": "what does this image show?" } ]	["edema", "terminal alcoholic cirrhosis", "typical facial appearance of edema", "jaundice", "generalized capillary permeability increase", "shock"]	{"edema": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region where tissue appears swollen due to increased fluid volume?", "Can you identify an area that might contain fluid with a clear or pale yellow appearance?", "Is there evidence of swelling in a dependent area, such as the lower limbs or sacral region?", "Does the image suggest the presence of tissue with increased water content, possibly exceeding 80% of its weight?", "Can you see a region where the fluid accumulation could range from several hundred milliliters to several liters?", "Is there an area that might contain fluid with a composition similar to plasma, including water, electrolytes, and protein?", "Does the image show swelling that could be due to fluid with a sodium concentration similar to plasma (approximately 135\u2013145 mmol/L)?", "Can you identify a region where the fluid might have a protein content consistent with either transudate (less than 3 g/dL) or exudate (greater than 3 g/dL)?", "Is there evidence of swelling where the fluid could have a specific gravity less than 1.015 or greater than 1.015, suggesting transudate or exudate?", "Does the image suggest the presence of fluid with a neutral to slightly alkaline pH, around 7.4?", "Can you see an area where the fluid's osmolarity might be similar to plasma, about 275\u2013295 mOsm/kg?", "Is there swelling in a region where the chloride concentration of the fluid could be close to plasma levels (around 98\u2013106 mmol/L)?", "Does the image show tissue that might contain fluid with a glucose concentration similar to plasma (approximately 70\u2013100 mg/dL)?", "Can you identify an area where the temperature of the accumulated fluid would likely reflect body temperature (36\u201337\u00b0C)?", "Is there a region where the clarity of the fluid could help distinguish between transudate (clear, non-turbid) and exudate (cloudy)?", "Does the image suggest a rate of fluid accumulation that could vary from several milliliters to liters per day depending on the underlying cause?"], "relational": ["Does the image show abnormal fluid accumulation in subcutaneous tissue or mucous membranes?", "Can you identify swelling in regions such as the lower limbs, ankles, or periorbital area?", "Is there evidence of fluid buildup in interstitial tissue or body compartments like the pleural or peritoneal cavity?", "Does the image display changes in organs such as the lungs, brain, liver, or kidneys that could indicate structural impact from excess fluid?", "Can you see signs of impaired lymphatic drainage, such as distended lymphatic vessels or lymph nodes?", "Is there visible swelling that could be related to lymphatic vessel dysfunction or obstruction?", "Does the image reveal features of the cardiovascular, renal, or lymphatic systems that might be involved in abnormal fluid retention?", "Are there indications of fluid accumulation in loose connective tissue or areolar tissue?", "Can you observe any alterations in capillaries, venules, or veins that might contribute to fluid leakage?", "Is there evidence of disruption to anatomical barriers like capillary endothelium or basement membrane that could affect fluid movement?"], "contexual_behavior": [], "functions": ["Does the image show evidence of tissue swelling that could indicate increased interstitial pressure?", "Can you identify an area where excess accumulation of interstitial fluid might be present?", "Is there a region where tissue fluid balance appears disrupted, possibly due to reduced fluid reabsorption?", "Does the image display localized swelling that could be associated with increased vascular permeability?", "Can you see signs of impaired organ function that might result from altered tissue architecture or increased pressure?", "Is there visual evidence suggesting that nutrient or oxygen delivery to tissues could be compromised, such as compressed capillaries or increased diffusion distance?", "Does the image show features that might indicate overloading or obstruction of lymphatic vessels, suggesting hindered lymphatic drainage?", "Can you identify areas where wound healing appears delayed, possibly due to increased infection risk or disrupted tissue repair?", "Is there a region where cellular signaling could be altered, such as changes in tissue structure that might affect cytokine gradients?", "Does the image reveal signs of chronic inflammation or tissue damage that could facilitate fibrosis?", "Can you see indications that metabolic waste removal from tissues might be impaired, such as slowed interstitial fluid flow or compromised venous and lymphatic clearance?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of sutures like the coronal, sagittal, or lambdoid sutures connecting bones in the image?", "Does the image display a region that encloses the cranial cavity?", "Can you identify blood vessels such as the middle meningeal artery or diploic veins associated with a bony structure?"], "contexual_behavior": [], "functions": ["Does the image include a feature that distributes impact forces to minimize direct injury to underlying tissues?", "Can you see a surface that could serve as an attachment point for scalp or facial muscles?", "Is there evidence of a structure capable of bone remodeling or repair in response to injury or stress?"]}}, "terminal alcoholic cirrhosis": {"yes_questions": {"contexual_properties": ["Does the image show an organ that appears shrunken, suggesting advanced chronic damage?", "Can you identify a structure with a nodular surface, indicating extensive fibrosis and regenerative nodules?", "Is there evidence of hardening or firmness in an organ due to replacement of normal tissue with fibrous material?", "Does the organ in the image have a yellow or greenish hue, possibly due to bile pigment accumulation?", "Can you see signs of increased fibrous tissue within an organ, consistent with chronic inflammation and collagen deposition?", "Is there visual evidence of fluid accumulation in the abdomen, which could be related to portal hypertension and low protein levels?", "Does the structure display an irregular surface, lacking normal smoothness due to fibrous septa and nodularity?", "Can you observe a reduction in the size or mass of an organ, possibly due to parenchymal loss and atrophy?", "Is there a change in the texture of the organ, such as increased firmness or fibrotic appearance?", "Do you notice abnormal fat deposits within the organ, suggesting fatty change or steatosis?", "Is there visible jaundice of the skin, indicating elevated bilirubin levels?", "Can you see any signs that might suggest the presence of regenerative nodules within the organ?", "Does the image show features consistent with ascites, such as abdominal distension?", "Is there any indication of vascular congestion or changes that might suggest increased portal vein pressure?", "Can you identify any changes in the color of urine or stool, such as dark urine or pale stools, that could be related to disrupted bilirubin metabolism?"], "properties": ["Is there an organ in the image that appears shrunken or atrophic compared to normal?", "Can you identify a structure with a firm, hard, and nodular surface?", "Does the image show an organ with coarse, irregular, and large nodularity on its surface?", "Is there evidence of extensive fibrosis or diffuse fibrous tissue replacing normal parenchyma?", "Can you see regenerative nodules surrounded by fibrous bands within the tissue?", "Does the depicted organ display a yellow-brown or greenish coloration?", "Is there a structure with reduced fat content, suggesting decreased steatosis?", "Can you identify an organ with reduced water content or dehydrated appearance?", "Is there visual evidence of increased iron deposition, such as areas suggestive of hemosiderosis?", "Does the tissue show a marked reduction in normal cell types, such as hepatocytes, with increased fibroblasts and inflammatory cells?", "Can you observe proliferating bile ductules within the tissue architecture?", "Is there a loss of normal lobular architecture, replaced by fibrous septa and nodules?", "Does the organ appear to have a decreased size or weight relative to what is expected for its type?", "Is there any indication of impaired protein synthesis or function in the depicted tissue?", "Can you identify features that might be associated with elevated portal pressure, such as congestion or vascular changes?", "Does the tissue show signs of increased collagen deposition or excessive fibrous material?", "Is there evidence of inflammatory cell infiltration within the organ?", "Can you see features that would suggest impaired coagulation, such as prolonged prothrombin time or related changes?", "Does the image suggest elevated bilirubin or ammonia levels through associated tissue changes?"], "relational": ["Does the image show evidence of altered hepatic lobules or portal tracts?", "Can you identify fibrous septa or bridging areas connecting different regions within the hepatic tissue?", "Is there visible replacement of normal parenchyma by fibrous tissue or regenerative nodules?", "Does the image display changes in the periportal or centrilobular regions?", "Can you see features suggesting bridging fibrosis between portal and central areas?", "Is there evidence of impaired or distorted portal vein branches or hepatic artery branches?", "Does the image suggest increased resistance or impaired flow in the portal vein, possibly indicating portal hypertension?", "Are intrahepatic bile ducts or canaliculi visibly affected or altered?", "Can you observe secondary changes in organs such as the spleen or kidneys that might be related to hepatic pathology?", "Is there any indication of hepatocyte necrosis or ballooning degeneration within the tissue?", "Does the image show increased fibroblast activity or proliferation in the hepatic tissue?", "Are sinusoidal capillaries or portal-central vein pathways visibly disrupted or abnormal?", "Can you identify any abnormalities in biliary drainage routes within the hepatic structure?", "Is there visual evidence of changes in the gastrointestinal tract that could be secondary to hepatic dysfunction?"], "contexual_behavior": ["Does the image show evidence of a structure with impaired detoxification leading to toxin accumulation?", "Is there a feature suggesting end-stage disease characterized by detoxification failure?", "Can you identify signs of coagulopathy, such as features consistent with clotting factor deficiency or extensive tissue loss?", "Does the image suggest impaired regulation of blood glucose, possibly due to hepatic dysfunction?", "Are there visual cues indicating decreased bile production or cholestasis resulting from severe fibrosis?", "Is there evidence of hyperammonemia or features that could be associated with urea cycle failure?", "Can you see indications of diminished protein synthesis, such as signs of albumin deficiency or hypoproteinemia?", "Does the image suggest impaired hormone metabolism or metabolic dysfunction due to disrupted enzymatic pathways?", "Are there features consistent with immune suppression or Kupffer cell dysfunction, increasing infection risk?", "Is there evidence of regeneration failure, such as extensive fibrosis or lack of cellular proliferation?", "Can you identify signs of impaired drug metabolism or enzyme deficiency, possibly leading to toxicity?", "Does the image show features that could indicate a glycogen storage deficit or energy imbalance?", "Are there visual clues suggesting cholesterol dysregulation or lipid metabolism disorder?", "Can you see signs of increased infection susceptibility or immune dysfunction, such as features consistent with sepsis risk?", "Is there evidence of fluid imbalance, such as ascites or electrolyte disturbance, possibly due to hypoalbuminemia?", "Does the image suggest hyperbilirubinemia or jaundice, indicating bilirubin clearance failure?", "Are there features that could indicate metabolic inflexibility or nutrient malabsorption due to impaired nutrient processing?", "Can you identify signs of portal hypertension or malnutrition resulting from nutrient processing deficit?", "Does the image show evidence of oxidative stress or cellular damage, possibly due to antioxidant deficiency?", "Are there features suggesting hepatic encephalopathy or neurotoxicity resulting from functional decline?", "Can you see signs of blood volume dysregulation, such as features consistent with hypoalbuminemia or vascular homeostasis disruption?"], "functions": ["Does the image show evidence of severe impairment in metabolic or detoxification functions, such as signs of liver failure or metabolic dysfunction?", "Can you identify features that suggest accumulation of toxins, like ammonia, which might indicate impaired detoxification or hepatic encephalopathy?", "Is there visual evidence of reduced bile production, such as signs of jaundice or cholestasis?", "Does the image display indications of disrupted carbohydrate, protein, or lipid metabolism, such as hypoglycemia or hyperlipidemia?", "Are there signs of compromised blood clotting, such as bleeding tendency or features suggesting coagulopathy?", "Can you observe indications of hormonal imbalance or altered steroid metabolism, possibly reflecting endocrine dysfunction?", "Is there evidence of increased resistance to blood flow, such as features consistent with portal hypertension or the presence of varices?", "Does the image suggest diminished ability to filter toxins from the blood, potentially leading to systemic toxicity or hepatic encephalopathy?", "Are there signs of decreased protein synthesis, such as hypoalbuminemia or muscle wasting (sarcopenia)?", "Can you identify features that might indicate weakened immune defense, such as signs of infection or reduced immune proteins?", "Is there visual evidence of disrupted fluid regulation, such as the presence of ascites or edema?", "Does the image show accumulation of waste products, such as hyperbilirubinemia or hyperammonemia?", "Are there signs of impaired glucose regulation, such as features suggesting hypoglycemia or insulin resistance?", "Can you observe indications of fat malabsorption, such as steatorrhea or nutrient deficiency?", "Is there evidence of compromised storage of vitamins or minerals, such as signs of vitamin or mineral deficiency?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image provide a view of organs like the lungs or heart?", "Is there visual evidence of bone deformities or abnormalities?", "Can you identify regions of the body like the chest, abdomen, or limbs in the image?"], "contexual_behavior": ["Does the image fail to reveal subtle changes that might be expected in early-stage lung disease, where findings are often radiographically occult?", "Are there overlapping anatomical structures in the image that could obscure pathology and reduce diagnostic confidence?", "Does the image reveal enhanced visualization of certain tissues or vessels, possibly due to the use of a contrast agent?"], "functions": ["Can you identify any bone discontinuities or misalignments that might indicate a fracture?", "Does the image appear to guide a medical procedure, such as catheter placement or orthopedic intervention?", "Does the image allow for evaluation of joints or the spine for structural changes, degeneration, or misalignment?"]}}, "typical facial appearance of edema": {"yes_questions": {"contexual_properties": ["Does the image show facial swelling that appears more pronounced in the morning or after lying down for a long time?", "Can you identify puffiness of the face that might be related to fluid overload, heart failure, or kidney problems?", "Is there visible soft tissue swelling of the face that could be due to interstitial fluid accumulation?", "Does the facial skin show discoloration that might suggest inflammation, poor venous return, or cyanosis?", "Can you see facial swelling that appears reduced, possibly after treatment or elevation?", "Is there a change in skin texture or evidence of skin stretching that could indicate chronic swelling or fibrosis?", "Does the swelling involve both sides of the face, suggesting a systemic condition like nephrotic syndrome or heart failure?", "Is there asymmetric facial swelling that could be due to localized infection, trauma, or lymphatic blockage?", "Can you observe increased firmness of the facial tissues that might be due to chronic swelling, fibrosis, or inflammation?", "Does the facial swelling show indentation after pressure, indicating pitting edema?", "Is there a shiny appearance of the facial skin that could result from significant fluid retention and skin stretching?", "Can you see changes in the normal facial contour or landmarks due to swelling?", "Is there redness of the facial skin that might be associated with inflammation or cellulitis?", "Does the facial swelling appear to have resolved or decreased, possibly after fluid reduction or treatment?", "Is there evidence of increased facial swelling during an acute exacerbation of a systemic or local disease process?"], "properties": ["Does the image show a face with puffiness or swelling?", "Can you identify fullness in the facial features present?", "Is there evidence of swelling that appears moderate, or does it range from mild to severe?", "Do you observe puffiness that is most prominent around the eyes, possibly extending to the cheeks or lips?", "Is there visible swelling in the periorbital region, such as the lower or upper eyelids?", "Does the facial swelling appear to affect both sides of the face equally, suggesting symmetry?", "Is the swelling or puffiness bilateral, involving both sides of the face?", "Does the skin on the face appear normal in color, pale, or slightly erythematous?", "Is the skin texture of the face smooth and stretched, possibly due to underlying fluid accumulation?", "Do the facial tissues look soft, or do they give the impression of being doughy or spongy?", "Is there an absence or only mild presence of indentation or pitting when observing the swollen areas, suggesting non-pitting edema?", "Does the swelling appear transient, as if it could last from hours to several days?"], "relational": ["Does the image show swelling in areas such as the periorbital region, cheeks, or lips?", "Can you observe changes in the subcutaneous tissue or dermis that suggest fluid accumulation?", "Is there visible puffiness affecting the eyelids, malar region, or lower jaw?", "Does the image contain signs of involvement of the lymphatic, circulatory, or integumentary systems in the facial area?", "Are the eyelids, cheeks, or lips noticeably altered in appearance compared to normal facial contours?", "Can you identify soft tissue swelling or loss of normal facial contours in the face?", "Is there evidence of impaired lymphatic drainage or fluid buildup in the facial tissues?", "Do facial muscles, blood vessels, or lymphatic vessels appear to interact with swollen regions?", "Are there structural changes in the scalp, neck, or periorbital tissues connected to facial swelling?", "Can you see features suggesting involvement of loose areolar tissue, collagen fibers, or the extracellular matrix in the affected facial areas?"], "contexual_behavior": [], "functions": ["Does the image show signs of facial swelling that could impair expression or cause discomfort?", "Can you identify visual evidence of excess fluid accumulation in the facial tissues?", "Is there any indication of compromised lymphatic drainage or increased vascular permeability in the facial region?", "Does the image suggest fluid retention, such as puffiness that might result from sodium or water retention or decreased oncotic pressure?", "Can you observe features consistent with increased hydrostatic pressure, reduced plasma protein levels, or possible lymphatic obstruction in the face?", "Is there visible puffiness or swelling that could be due to altered capillary permeability and plasma leakage into the interstitial space?", "Does the facial appearance indicate a disruption in tissue fluid homeostasis, such as an imbalance between filtration and reabsorption?", "Can you see facial changes that might serve as a diagnostic indicator of systemic or local dysfunctions, such as heart failure, renal disease, or localized inflammation?"]}, "no_questions": {"contexual_properties": ["Is there a region displaying abnormal growth patterns suggestive of hydatidiform mole or choriocarcinoma?", "Is there a mass formation visible that could correspond to choriocarcinoma or an invasive mole?", "Is there evidence of excessive tissue growth, possibly indicating a gestational trophoblastic neoplasm or complete mole?"], "properties": ["Can you identify regions where the surface layer of the chorion appears thicker than usual?", "Does the image contain any abnormal growth or expansion of the chorionic surface layer?", "Does the image show evidence of increased cell numbers in the outermost fetal membrane?"], "relational": ["Can you identify a region contributing to the structure of the placenta?", "Can you see a fetal membrane that is related to the amnion, yolk sac, or allantois?", "Does the image show a region that forms the outermost fetal layer of the placenta?"], "contexual_behavior": ["Can you identify regions where the epithelial layer of the chorion appears thicker or denser than usual?", "Does the image contain areas suggestive of enhanced cell division within the chorionic surface?", "Is there a visible indication of abnormal growth or expansion in the tissue covering the fetal side of the placenta?"], "functions": ["Is there a robust barrier apparent that might limit immune cell infiltration and help protect the fetus from maternal immune responses?", "Does the image provide visual cues of active cell proliferation, differentiation, or tissue remodeling within placental structures?", "Can you see evidence of cellular expansion contributing to the outgrowth or development of villous structures?"]}}, "jaundice": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show an individual with yellow discoloration of the skin or the whites of the eyes?", "Can you observe any signs that might indicate elevated bilirubin levels above 2\u20133 mg/dL?", "Is there visual evidence suggesting the presence of dark or tea-colored urine?", "Does the image include stool that appears pale or clay-colored?", "Can you identify features that might suggest the person is a newborn within the first week of life?", "Is there any indication that the individual could have elevated liver enzyme levels such as ALT, AST, or ALP?", "Based on visible signs, can you estimate whether the severity of the condition might be mild, moderate, or severe?", "Does the image suggest that the yellow discoloration has been present for days to weeks?", "Are there visual cues that the yellow discoloration is resolving, possibly within 1\u20134 weeks after treatment?"], "relational": ["Does the image show any evidence of altered coloration in tissues such as the skin or sclera?", "Can you identify any changes in the appearance of the hepatic system or digestive system that might indicate impaired bilirubin metabolism?", "Is there a visible structure, such as the liver or gallbladder, that appears abnormal or affected?", "Does the image reveal any signs of obstruction or inflammation in the biliary tract, such as the common bile duct or hepatic ducts?", "Can you see any anatomical features suggesting dysfunction in bile flow?", "Is there any indication of blood plasma or mucous membranes displaying unusual coloration?", "Does the image show any relationship between the pancreas and the bile duct that could suggest compression or obstruction?", "Are there visible abnormalities in the portal vein or cystic duct that could be associated with impaired bilirubin excretion?", "Can you identify any features in the small intestine that might be related to bilirubin clearance?", "Is there any evidence of interaction between hepatic tissue and bilirubin, such as discoloration or textural changes?"], "contexual_behavior": [], "functions": ["Is there evidence of yellow discoloration affecting the skin or the whites of the eyes in the image?", "Can you observe any signs that might suggest elevated levels of bilirubin, such as changes in skin or sclera coloration?", "Does the image show features that could indicate impaired metabolism or accumulation of bile pigments in the body?", "Is there a visible indication of compromised liver function, such as changes in tissue color or texture?", "Can you identify any signs that might be associated with increased breakdown of red blood cells, such as pallor or other indirect indicators?", "Does the image suggest impaired detoxification processes, possibly due to hepatic overload?", "Are there visual clues pointing to retention of bile pigments, such as abnormal coloration of tissues?", "Can you see any features that might suggest altered excretion, like dark urine or pale stools if these are visible in the image?", "Is there evidence of impaired digestion or nutrient absorption, such as signs of malnutrition or wasting?", "Does the image show features that could be related to dysregulated blood bilirubin levels?", "Can you observe any indications of anemia, such as pallor, that might suggest decreased tissue oxygenation?", "Are there visual signs that could be associated with increased oxidative stress or antioxidant imbalance in the tissues?"]}, "no_questions": {"contexual_properties": ["Does the image reveal abnormal endometrial thickness, which could be associated with inflammation or retained products after childbirth?", "Are there visual signs of microabscesses or localized collections within the endometrial tissue?", "Can you detect increased vascularity or hyperemia in the uterine lining, consistent with a vascular response to inflammation?"], "properties": [], "relational": ["Can you see any abnormalities at the site where the placenta was previously attached?", "Can you identify an area where the endometrial lining appears altered or inflamed?", "Can you observe any anatomical barriers, like the peritoneum or broad ligament, that might limit the spread of inflammation?"], "contexual_behavior": [], "functions": ["Is there visual evidence of increased leukocyte infiltration or heightened immune activity in the uterine tissue?", "Is there evidence of abnormal discharge or impaired regeneration of the endometrial lining?", "Can you identify signs of delayed healing or abnormal tissue remodeling in the uterus postpartum?"]}}, "generalized capillary permeability increase": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of a pathological state characterized by unusually high permeability of small blood vessels?", "Can you identify signs of widespread and severe fluid accumulation affecting multiple tissues or organs?", "Is there visual evidence suggesting that plasma proteins, such as albumin, have leaked into the interstitial space at levels exceeding 1\u20132 g/dL?", "Does the image suggest a condition where several liters of fluid may be lost from the capillaries each day?", "Are there indications that the onset of tissue changes occurred acutely within hours and may persist for days?", "Can you see signs consistent with the passage of large molecules, such as proteins up to 70 kDa, from blood vessels into surrounding tissues?", "Is there evidence that the concentration of albumin in the interstitial fluid could be as high as 50\u201370% of its plasma concentration?", "Does the image suggest that the hydrostatic pressure within small blood vessels is within the range of 25\u201330 mmHg or slightly elevated?", "Are there features indicating that the oncotic pressure in the interstitial space is increased while plasma oncotic pressure is decreased?", "Can you identify a scenario where the thickness of the capillary walls appears normal, but their barrier function is compromised, leading to abnormal fluid and protein movement?"], "relational": ["Does the image show evidence of altered fluid exchange within the cardiovascular or lymphatic systems?", "Can you identify changes in connective, endothelial, or interstitial tissues that might indicate increased permeability?", "Is there a visible alteration in capillary types such as continuous, fenestrated, or sinusoidal vessels?", "Does the image display interactions between capillaries and structures like the basement membrane or interstitial space?", "Are there signs of increased permeability in regions such as the skin, lungs, kidneys, or gastrointestinal tract?", "Can you observe endothelial cells, pericytes, or leukocytes within capillaries that appear affected?", "Is there visual evidence of disrupted vascular permeability or changes in microcirculation?", "Do any organs such as the lungs, kidneys, liver, or brain appear impacted by changes in capillary permeability?", "Can you see alterations in extracellular matrix, plasma proteins, or interstitial fluid that suggest increased permeability?", "Are there structural changes in capillaries, such as disrupted endothelial junctions or increased pore formation, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show evidence of fluid accumulation in tissues that could indicate enhanced leakage of plasma components?", "Can you identify signs of swelling or edema that might result from increased movement of fluid from blood vessels into the interstitial space?", "Is there visual evidence of tissue changes that could be associated with transudation or exudation?", "Does the image suggest the presence of an inflammatory response, such as immune cells migrating into affected tissues?", "Can you see features that might indicate protein leakage or loss, such as tissue swelling or abnormal fluid retention?", "Is there any indication of leukocyte migration from blood vessels into surrounding tissues?", "Does the image reveal signs of disrupted tissue homeostasis, such as protein imbalance or abnormal fluid distribution?", "Can you observe tissue characteristics that might be consistent with wound healing or tissue repair involving increased delivery of immune factors?", "Is there evidence of altered nutrient transport or impaired waste clearance that could result from changes in fluid dynamics?", "Does the image display features that could be linked to complications of disease processes like sepsis, allergic reactions, or acute respiratory distress syndrome?"]}, "no_questions": {"contexual_properties": ["Does the tissue show signs of fatty replacement, which could occur with aging, after menopause, or following significant weight loss?", "Is there increased nodularity that might be explained by fibrocystic changes, hormonal fluctuations, or benign proliferative disorders?", "Is there asymmetry between paired structures that could result from developmental variation, trauma, surgery, tumor, or localized swelling?"], "properties": ["Does the image show a protruding structure with a diameter of about 1 to 1.5 centimeters?", "Is there an area where the tissue pH could be slightly acidic, around 7.0 to 7.4?", "Is there a region where water content might account for 30% to 40% of the tissue by weight?"], "relational": ["Does the image show a structure that is part of both the integumentary and reproductive systems?", "Is there an area composed of glandular, adipose, and connective tissues?", "Does the image show ducts that could transport secretions to the surface?"], "contexual_behavior": ["Can you identify a structure that may fail to respond to hormonal stimulation in cases of endocrine dysfunction?", "Can you see signs of increased inflammatory response and reduced secretion that might occur during mastitis?", "Does the image show a structure that could increase milk production in response to infant suckling?"], "functions": ["Can you see evidence of a system that supports passive immunity in infants?", "Is there a structure that could transfer immunoglobulins or antimicrobial proteins to an infant?", "Can you identify an area responsible for milk production and secretion?"]}}, "shock": {"yes_questions": {"contexual_properties": [], "properties": ["Is there evidence of a patient with low blood pressure, such as a systolic value below 90 mmHg?", "Can you identify signs of an elevated heart rate, for example, a pulse exceeding 100 beats per minute?", "Does the image suggest a body temperature below 36\u00b0C, indicating possible hypothermia?", "Is there any indication of reduced oxygen saturation, such as SpO2 values under 94%?", "Can you see laboratory results or monitors showing blood lactate levels above 2 mmol/L?", "Is there evidence of decreased urine output, for example, less than 0.5 mL/kg/hr?", "Does the image display a blood pH value below 7.35, suggesting acidemia?", "Can you identify a respiratory rate greater than 20 breaths per minute?", "Is there a central venous pressure measurement below 8 mmHg, except in cases of cardiac or obstructive causes?", "Does the image show a capillary refill time longer than 2 seconds?", "Are there visible signs of pale, cool, or mottled skin?", "Can you observe blood glucose values that are either abnormally low or high?", "Is there evidence of cardiac output less than 4 L/min in an adult patient?", "Does the image indicate a base excess value less than -2 mmol/L, suggesting a base deficit?", "Are there signs of altered mental status, such as confusion or reduced consciousness?"], "relational": ["Does the image show evidence of impaired function in the cardiovascular, respiratory, renal, or nervous systems?", "Can you identify tissues such as muscle, nervous, epithelial, or endothelial tissue that appear affected by a systemic process?", "Is there a visible alteration in organs like the heart, kidneys, brain, or liver that could be related to changes in blood flow?", "Are there anatomical structures such as blood vessels, the heart, adrenal glands, or lungs that display signs of an acute systemic response?", "Does the image reveal abnormalities in arteries, veins, or capillaries that might indicate a disruption in blood flow?", "Can you observe features consistent with hypoperfusion, hypotension, or impaired circulation within the cardiovascular system?", "Is there evidence of injury or dysfunction in the brain, kidneys, heart, or gastrointestinal tract that could be attributed to compromised perfusion?", "Are cellular components like endothelial cells, leukocytes, platelets, or erythrocytes visibly altered in a way that suggests a systemic response?", "Does the image show compensatory changes in the cardiovascular, endocrine, or respiratory systems?", "Can you identify disruptions in systemic circulation, microcirculation, or oxygen delivery pathways within the depicted structures?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a condition characterized by low blood pressure and rapid heart rate?", "Can you identify signs of reduced tissue perfusion, such as pallor or cyanosis, in the depicted structures?", "Is there visual indication of impaired oxygen delivery to organs, such as hypoxemia or organ dysfunction?", "Does the image suggest systemic vasodilation or decreased cardiac output affecting blood pressure regulation?", "Are there features consistent with metabolic disturbances like lactic acidosis or signs of energy failure?", "Can you observe compensatory mechanisms such as increased heart rate or vasoconstriction in the cardiovascular system?", "Is there evidence of impaired function in organs like the kidneys, liver, or brain that could indicate organ dysfunction?", "Does the image display signs of an exaggerated inflammatory response, such as tissue swelling or increased vascular permeability?", "Can you see indications of fluid imbalance, such as edema or third-spacing of fluids?", "Is there visual evidence of multi-organ dysfunction or systemic inflammation due to sustained hypoperfusion?", "Are there signs of impaired waste removal, such as accumulation of metabolites or renal dysfunction?", "Does the image suggest altered blood flow distribution, with centralization to vital organs and reduced perfusion to peripheral tissues?", "Can you identify changes in the cardiovascular system, such as decreased cardiac output or altered vascular resistance?", "Is there evidence of disrupted homeostasis, such as abnormal temperature regulation, acid-base disturbance, or electrolyte imbalance?", "Does the image suggest increased susceptibility to infection or impaired immune response, possibly due to immunosuppression?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see a structure whose volume could be estimated as less than 20 milliliters?", "Is there a collection measuring between 1 and 4 centimeters in its greatest dimension?", "Can you identify a localized area within the temporal muscle or adjacent fascia that appears hyperdense or bright on CT?"], "relational": ["Does the image reveal changes within skeletal muscle tissue, subcutaneous tissue, or periosteum in the temporal area?", "Can you identify any disruption or abnormality adjacent to the temporal bone or zygomatic bone?", "Can you see any abnormality within the temporal fossa or masticator space?"], "contexual_behavior": ["Does the image suggest that ongoing pain, swelling, or tissue damage could limit the effectiveness of physical therapy in the temporal muscle?", "Is there evidence of muscle fiber disruption that could interfere with normal contraction in the temporal region?", "Can you identify signs of local vascular compression or reduced blood supply to muscle fibers near the side of the head?"], "functions": ["Can you observe features that might reflect decreased blood flow or vascular compression in a masticatory muscle?", "Does the image reveal tissue changes that could activate nociceptors or cause local irritation?", "Does the image suggest weakness or dysfunction in a muscle involved in mastication, potentially leading to painful chewing?"]}}}
[ { "answer": "yes", "extracted_concepts": [], "question": "does this image show grotesque?" }, { "answer": "anencephaly", "extracted_concepts": [ "anencephaly" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "anencephaly" ], "question": "is anencephaly present?" }, { "answer": "anencephaly", "extracted_concepts": [ "anencephaly" ], "question": "what is present?" } ]	["anencephaly"]	{"anencephaly": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show an individual with a markedly reduced cranial size compared to normal?", "Is there evidence of microcephaly or a head circumference far below the expected range for gestational age?", "Can you identify a case where the cranial vault appears absent or severely underdeveloped, potentially exposing underlying tissue?", "Is there visible neural tissue that appears dark red to purple and has a friable, gelatinous texture?", "Does the image reveal disorganized or incomplete remnants of forebrain and midbrain structures?", "Can you see exposed neural tissue with a disorganized appearance and absence of the cerebrum?", "Is there a near-complete absence of skull bones in the cranial region?", "Does the brain tissue volume appear severely diminished, possibly limited to rudimentary brainstem structures?", "Is there evidence of malformed brainstem or primitive neural elements with no visible cerebral hemispheres?", "Can you infer from the image that the brain weight would likely be significantly below normal, possibly less than 100 grams?"], "relational": ["Does the image show absence or severe malformation of major structures such as the cerebral hemispheres or cranial vault?", "Is there a region of the head where the scalp appears missing or abnormal?", "Can you identify abnormalities affecting the forebrain or midbrain regions?", "Does the image reveal missing parts of the brain such as the cerebral cortex or cerebrum?", "Is there evidence of absent or malformed diencephalon in the cranial area?", "Are the bones of the skull or meninges visibly absent or disrupted?", "Can you see areas where neural tissue is exposed or not covered by cranial bone or skin?", "Is there a failure of cranial bone or overlying ectoderm development visible in the image?", "Does the image suggest a disruption in neural tube closure, particularly at the anterior end?", "Are there visible abnormalities in both the nervous and integumentary systems of the head?", "Can you identify regions where embryological structures such as the neural plate or neural folds may have failed to develop properly?", "Is the interface between the brain and skull altered, with evidence of exposed neural tissue?", "Does the upper facial region or calvaria appear structurally abnormal or incomplete?", "Is there a lack of normal scalp covering the cranial region?", "Are the skull bones missing or severely underdeveloped in the cranial area?"], "contexual_behavior": ["Does the image show evidence of a neural tube defect affecting the development of brain structures during early embryogenesis?", "Can you identify a fetus with malformation or absence of major brain regions that would disrupt central autonomic control?", "Is there a visible absence or severe underdevelopment of the forebrain and cerebrum, suggesting reduced neural control of vital physiological processes?", "Does the image indicate impaired coordination of fetal movement due to missing or underdeveloped motor cortex and neural circuits?", "Can you observe signs of failed sensory processing in the fetus, possibly due to missing sensory relay centers in the brain?", "Is there evidence of disrupted signaling between the brain and other organs, as might occur if neural pathways for inter-organ communication are absent?", "Does the image suggest abnormal regulation of heart rate or respiration that could result from a malformed or absent brainstem?", "Can you see indications that hypothalamic or pituitary structures have failed to develop, potentially affecting neurohormone production?", "Is there a decreased capacity for reflex responses in the fetus, possibly due to incomplete or absent neural circuits in the brain?", "Does the image show a lack of integration of neural pathways necessary for survival after birth, as would be expected if critical brain regions are missing?"], "functions": ["Does the image show an individual with severe malformation of the brain, particularly lacking the cerebral hemispheres and forebrain?", "Can you identify a case where neural regulation of vital physiological processes such as breathing and heart rate appears critically compromised?", "Is there evidence of profound sensory and motor deficits due to missing essential brain structures?", "Does the image suggest inadequate regulation of involuntary functions like blood pressure or digestion, indicating autonomic instability?", "Can you observe signs of impaired respiratory or cardiovascular regulation, such as respiratory failure or abnormal heart function?", "Is there an absence of normal reflexes or basic survival behaviors, possibly due to missing neural circuits in the brainstem or higher centers?", "Does the image indicate disruption of hormonal regulation or homeostasis, such as impaired hypothalamic or pituitary function?", "Can you see evidence of abolished movement coordination or postural instability, potentially due to absent cerebrum and cerebellum?", "Is there a complete lack of consciousness or cognitive function, as might be expected if the cerebral cortex is not developed?", "Does the image suggest a loss of communication between organ systems, possibly due to missing central neural pathways?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of invasion into neighboring organs such as the bowel, bladder, diaphragm, or spleen?", "Can you identify an abnormal mass affecting organs such as the lung, liver, kidney, ovary, or colon?", "Is there a structure in the image that appears to arise from epithelial, connective, muscle, or nervous tissue?"], "contexual_behavior": [], "functions": ["Does the mass appear to influence surrounding tissues by secreting substances that could alter cellular signaling or promote growth?", "Can you see a mass that appears to block hollow organs or passageways, which might result in pain or organ dysfunction?", "Does the image show evidence of blood vessels being compressed or invaded, possibly leading to reduced blood flow or congestion?"]}}}
[ { "answer": "this benign tumor", "extracted_concepts": [ "expansile growth pattern", "pushing circumscribed borders", "benign tumor" ], "question": "what has an expansile growth pattern with pushing circumscribed borders?" }, { "answer": "an expansile growth pattern with pushing circumscribed borders", "extracted_concepts": [ "expansile growth pattern", "pushing circumscribed borders", "benign tumor" ], "question": "what does this benign tumor have?" }, { "answer": "yes", "extracted_concepts": [ "expansile growth pattern", "pushing circumscribed borders", "benign tumor" ], "question": "does this benign tumor have an expansile growth pattern with pushing circumscribed borders?" }, { "answer": "no", "extracted_concepts": [ "bone marrow", "pushing circumscribed borders", "expansile growth pattern", "infant" ], "question": "does bone marrow from an infant have an expansile growth pattern with pushing circumscribed borders?" } ]	["expansile growth pattern", "infant", "pushing circumscribed borders", "bone marrow", "benign tumor"]	{"expansile growth pattern": {"yes_questions": {"contexual_properties": ["Is there a mass in the image that appears to be enlarging within a confined tissue space without infiltrating adjacent structures?", "Can you identify a lesion that is pushing aside surrounding normal tissues rather than invading them?", "Does the image show a structure with a well-circumscribed border, clearly demarcated from neighboring tissues?", "Is there evidence of increased cellular density within an expanding area of tissue?", "Can you see a mass that is compressing or distorting the structure of adjacent tissues?", "Is there a region where the surrounding tissues appear displaced due to the presence of an enlarging mass?", "Does the image reveal a mass with increased vascularity, suggesting angiogenesis to support its growth?", "Are there areas within a lesion that appear necrotic, possibly due to outgrowing their blood supply?", "Can you observe changes in the size, cellularity, or composition of a mass that might indicate a response to therapy?", "Is there a mass with a multilobulated appearance, showing multiple lobular projections or irregular expansion?", "Do you see evidence of compositional changes within a lesion, such as fibrosis, hemorrhage, or cystic transformation?", "Is there a region within a mass that appears cystic, possibly due to liquefaction or cyst formation?", "Can you identify areas of calcification within an expanding lesion, suggesting dystrophic mineralization?", "Does the border of a mass appear less defined, possibly indicating secondary infiltration or irregular growth at the margins?"], "properties": ["Does the image show a lesion with a size ranging from a few millimeters to several centimeters?", "Can you identify a structure with a rounded or lobulated shape?", "Is there an area that appears larger in volume compared to surrounding infiltrative patterns?", "Does the image display a mass with well-defined, smooth borders compressing adjacent tissues?", "Can you see a region with moderate to high cellular density?", "Is there a lesion where the mitotic activity appears low to moderate, as might be seen in benign growths?", "Does any area show cells with a normal or only mildly increased nuclear-cytoplasmic ratio?", "Can you identify a region with low or only focal necrosis, unless the lesion seems to have outgrown its blood supply?", "Is there evidence of moderate stromal content, particularly with stroma compressed at the periphery of a mass?", "Does any tissue appear tan to pale on gross examination?", "Can you observe a solid or cohesive texture in the lesion under microscopic view?", "Is there a structure composed of multiple cell layers forming nests or sheets?", "Does the image show moderate vascularity with supporting blood vessels for an expanding mass?", "Can you see moderate collagen content, especially within compressed stroma at the lesion's edge?", "Is there an arrangement of cells in cohesive nests, sheets, or lobular patterns?"], "relational": ["Does the image show a mass that displaces surrounding parenchyma or connective tissue without invading it?", "Can you identify a lesion with smooth borders and clear margins separating it from adjacent tissues?", "Is there evidence of a compressive effect on neighboring organs or structures, such as displacement rather than infiltration?", "Does the image contain a tumor that could be classified as an adenoma, mucinous carcinoma, or benign neoplasm?", "Can you see a structure that appears well-circumscribed, possibly surrounded by a fibrous capsule or pseudocapsule?", "Is there a mass effect altering the parenchymal compartment, lobular units, or submucosal layer of an organ?", "Does the image show a lesion in the liver, ovary, or lung that is pushing aside but not invading surrounding tissue?", "Can you identify a growth pattern that is non-infiltrative, with a lack of tissue infiltration into the stroma?", "Is there a visible boundary formed by an organ capsule, basement membrane, or dense connective tissue limiting the spread of a mass?", "Does the image show a structure that could be part of the digestive, reproductive, or respiratory system exhibiting a compressive mass?"], "contexual_behavior": ["Is there evidence of a tumor mass that appears confined within a space without invading adjacent tissues, suggesting a non-invasive process?", "Can you identify a lesion whose expansion seems reduced, possibly indicating the effects of chemotherapy or increased cell death?", "Does the image show a tumor where the growth pattern appears to transition from confined expansion to invasion of surrounding tissues, which could be a response to hypoxic conditions?", "Is there a mass where the boundary with surrounding tissue is poorly maintained, suggesting the acquisition of invasive properties during malignancy?", "Do you observe a lesion with a well-demarcated border, more characteristic of benign neoplasms due to the lack of tissue invasion?", "Is there a tumor whose growth pattern appears less distinct, possibly due to chronic inflammation disrupting normal tissue architecture?", "Can you see a mass whose expansion seems limited by the presence of dense fibrotic tissue acting as a physical barrier?", "Is there a lesion that appears to be enlarging rapidly, consistent with increased cell division and accelerated tumor growth?", "Does the image show a tumor with slowed expansion, which could be due to reduced vascularization following anti-angiogenic therapy?", "Is there evidence of immune cell infiltration around a tumor, potentially restricting its expansion?", "Can you identify a mass whose growth pattern appears altered, possibly due to changes in the rigidity of the surrounding extracellular matrix?", "Is there a lesion in hormone-responsive tissue that appears to be expanding more prominently, potentially due to hormonal stimulation?", "Does the image show a tumor with decreased expansion and signs of tissue damage, which may be a result of radiation therapy?", "Is there a mass whose growth dynamics differ from surrounding lesions, possibly indicating a shift in pattern during tumor recurrence?", "Can you see a tumor whose expansion appears impaired in an area with reduced blood supply, suggesting hypovascularity?"], "functions": ["Does the image show a mass that appears to push aside, rather than invade, the surrounding tissues?", "Can you identify a lesion that compresses and displaces adjacent structures without directly infiltrating them?", "Is there evidence of a well-circumscribed mass that maintains clear boundaries with neighboring tissues?", "Does the image contain a structure that causes compression of nearby tissues, possibly leading to visible remodeling or displacement?", "Can you see a mass that appears to expand locally with minimal invasion into the surrounding stroma?", "Is there a lesion that seems to grow in a localized manner, without aggressive spread into adjacent tissues?", "Does the image show a mass that could be palpable and well-defined, with less aggressive visual features?", "Can you identify a structure that appears to have limited or no invasion into blood vessels or lymphatic channels?", "Is there evidence of tissue compression that might result in mass effect or pressure on adjacent anatomical structures?", "Does the image suggest impairment of organ function due to compression, rather than destruction, of normal tissue?", "Can you see a mass whose visual characteristics suggest a lower likelihood of early metastasis due to limited invasion?"]}, "no_questions": {"contexual_properties": ["Is there evidence of enlarged nuclei that could indicate dysplasia or malignant transformation?", "Can you see a loss of tissue organization that might be associated with neoplasia or severe inflammation?", "Does the image show evidence of increased cell size that might indicate hypertrophy or cellular adaptation?"], "properties": ["Are the nuclei within the cells approximately 5 to 10 micrometers in diameter?", "Are the majority of cells in the image between 10 and 30 micrometers in diameter?", "Do the cells exhibit round, polygonal, or elongated shapes depending on their location or function?"], "relational": ["Does the tissue exhibit distinct layers, functional units, or specific cellular arrangements?", "Does the image show anatomical structures like glands, blood vessels, nerves, or basement membranes?", "Does the image display tissue organization characteristic of the digestive, respiratory, nervous, or cardiovascular systems?"], "contexual_behavior": ["Can you see damage to excretory cells or disrupted clearance mechanisms, suggesting impaired waste removal following toxin exposure?", "Can you observe features such as cellular senescence or mitochondrial dysfunction that would indicate reduced metabolic activity, as seen during aging?", "Can you identify areas where cellular organization appears lost, possibly due to oxygen deprivation leading to swelling and disarray?"], "functions": ["Does the tissue display a balanced composition of cell types and extracellular components, suggesting maintenance of integrity and function?", "Can you observe features such as organized vascular structures or cell layers that would facilitate optimal nutrient and waste exchange?", "Is there evidence of structural cues or microenvironments that could guide cell movement and differentiation within the tissue?"]}}, "infant": {"yes_questions": {"contexual_properties": ["Is there an individual in the image who appears to be in a phase of rapid weight gain, characteristic of early life growth spurts?", "Can you identify someone who may have recently experienced physiological weight loss due to postnatal adaptation?", "Does the image show a person whose skin color suggests circulatory adjustment, such as acrocyanosis or jaundice?", "Is there evidence of abnormal head circumference increase that could indicate neurological disorders like hydrocephalus?", "Can you observe an individual whose length growth appears to be slowing, consistent with developmental milestones after the first year?", "Is there a visible sign of jaundice, such as yellowish skin, that might suggest immature liver function in the first week of life?", "Does anyone in the image display decreased muscle tone, possibly indicating hypotonia or neuromuscular disorders?", "Is there an individual who appears to be affected by hypothermia, such as showing signs of cold exposure or prematurity?", "Can you see a sunken fontanelle, which could be a clinical sign of dehydration or fluid imbalance?", "Is there a bulging fontanelle visible, potentially indicating increased intracranial pressure or meningitis?", "Does the skin of any individual appear mottled, which might suggest circulatory instability or shock?", "Is there a person who could be experiencing hypoglycemia, as indicated by signs of prematurity or feeding issues?", "Can you observe signs that might indicate elevated bilirubin levels, such as yellowish discoloration of the skin?", "Is there evidence of decreased oxygen saturation, such as signs of respiratory distress or cardiac disorders?", "Does anyone in the image appear to have an increased heart rate, possibly due to fever, dehydration, or infection?", "Is there a visible increase in respiratory rate, which could be a response to respiratory distress or metabolic disorders?", "Can you identify swelling or puffiness that might suggest edema from renal or cardiac conditions?", "Is there an indication that weight gain has plateaued, possibly due to illness or inadequate nutrition?", "Does the skin appear dry or flaky, which could be associated with post-term birth, eczema, or dehydration?", "Is there visual evidence of increased fat mass or changing body composition typical of early developmental stages?"], "properties": ["Does the image show a person whose estimated weight is around 3.2 to 3.4 kilograms?", "Is there an individual whose length appears to be approximately 50 centimeters?", "Can you identify someone with a head circumference likely between 33 and 35 centimeters?", "Does the image include a person whose chest circumference seems to be about 30 to 33 centimeters?", "Is there a subject whose body temperature would typically be between 36.5 and 37.5 degrees Celsius?", "Can you see an individual whose heart rate is expected to be in the range of 120 to 160 beats per minute?", "Is there someone present whose respiratory rate would normally fall between 30 and 60 breaths per minute?", "Does the image show a person whose blood pressure is likely around 60/40 to 80/50 mmHg?", "Is there an individual with a healthy pink skin color?", "Can you identify someone whose hemoglobin level is expected to be between 14 and 20 grams per deciliter?", "Is there a subject whose white blood cell count would typically range from 9,000 to 30,000 per microliter?", "Does the image include a person whose platelet count is likely between 150,000 and 400,000 per microliter?", "Can you see an individual whose glucose level would normally be 40 to 100 milligrams per deciliter?", "Is there a subject whose bilirubin level at birth is less than 5 milligrams per deciliter, possibly rising to 12 mg/dL in the first week?", "Does the image show a person with an estimated body fat percentage of about 13 to 15 percent?", "Is there an individual whose Apgar score at birth would typically be in the range of 7 to 10?", "Can you identify someone whose oxygen saturation level is expected to be between 95 and 100 percent?", "Is there a subject whose daily urine output would be approximately 1 to 3 milliliters per kilogram per hour?", "Does the image include a person whose serum calcium level is likely between 8 and 10.5 milligrams per deciliter?", "Can you see an individual whose serum sodium level would normally be 135 to 145 milliequivalents per liter?"], "relational": ["Does the image show an individual with all major anatomical systems present, such as the nervous, cardiovascular, and musculoskeletal systems?", "Can you identify a figure with body parts including a head, trunk, limbs, hands, and feet?", "Is there a subject with visible features like eyes, ears, or mouth?", "Does the image display a head with soft spots or gaps between the cranial bones, such as an anterior or posterior fontanelle?", "Can you see evidence of open sutures or unfused regions in the skull?", "Is there a figure whose head appears proportionally larger compared to the rest of the body?", "Does the subject have a prominent abdomen or cheeks relative to the rest of the body?", "Can you observe any signs of tissues that are still developing, such as bone or cartilage?", "Is there a visible structure that suggests the presence of functional lungs and independent feeding ability?", "Does the image lack any connection to the placenta or umbilical cord, indicating closed umbilical circulation?", "Can you see skeletal elements, such as cranial sutures or epiphyseal plates, that have not yet fused?", "Is there a visible thymus or liver that appears relatively large for the body size?", "Does the subject display open fontanelles as opposed to a fully fused skull?", "Are there features indicating ongoing structural changes in organ systems like the nervous or immune system?", "Can you identify a figure with especially prominent eyes?"], "contexual_behavior": ["Does the image show a young individual who may have increased susceptibility to infections due to immature immune responses?", "Is there evidence of a person in the early stage of life who might be undergoing dietary transition, such as weaning or introduction of solid foods?", "Can you identify a subject who could be at risk of impaired thermoregulation in cold environments because of limited subcutaneous fat?", "Does the image depict someone likely experiencing rapid growth and high metabolic demand characteristic of the first year of life?", "Is there a young individual who may have decreased nutrient absorption during illness due to gastrointestinal disturbances?", "Can you see a person whose respiratory function might be compromised during infections like bronchiolitis or pneumonia?", "Is there a subject whose sleep-wake cycle could be influenced by environmental light as circadian rhythms develop?", "Does the image include someone whose ability to concentrate urine is still maturing, as seen by the end of the first year of life?", "Can you identify a person who may be at risk for jaundice due to immature bilirubin metabolism?", "Is there a young individual whose cardiovascular system is adapting to life outside the womb, such as through closure of fetal shunts?", "Does the image show someone whose antibody production could increase following vaccination due to adaptive immune response development?", "Is there a subject who might experience glucose instability during fasting because of limited glycogen stores and immature gluconeogenesis?", "Can you see a person whose thermoregulatory ability improves with age as physiological mechanisms mature and body fat increases?", "Is there evidence of a young individual whose immune function could be affected by disruption of gut microbiota after antibiotic exposure?", "Does the image depict someone whose feeding behavior might change during illness or teething due to decreased appetite or oral discomfort?", "Can you identify a subject likely to be undergoing accelerated bone growth during growth spurts in early life?", "Is there a person whose lung function could improve after treatment for respiratory distress, such as surfactant or oxygen therapy?", "Does the image show a young individual at increased risk of dehydration during fever or diarrhea due to higher fluid losses?", "Is there a subject whose neurological function could be impaired by hypoxia, especially during birth complications or respiratory failure?", "Can you see a person whose immune response to pathogens may differ from older children due to reliance on innate immunity and limited memory responses?"], "functions": ["Does the image show an individual exhibiting rapid growth or high metabolic activity?", "Can you identify someone with immature organ systems, such as underdeveloped immunity or kidneys?", "Is there a subject whose body temperature might be regulated by brown adipose tissue rather than shivering?", "Does the image include an individual likely to rely on maternal antibodies for immune protection?", "Can you see someone whose nutrient absorption is primarily through enzymatic digestion of breast milk or formula?", "Is there a person with a high respiratory rate and a compliant chest wall?", "Does the image show an individual with ongoing neurodevelopment, such as active myelination or synaptogenesis?", "Can you identify someone with high total body water content and immature renal function?", "Is there a subject whose metabolic processes include accelerated protein synthesis and increased fat utilization?", "Does the image contain an individual who may have frequent feeding to regulate blood glucose levels?", "Can you see someone whose digestive system is adapted for milk digestion with high lactase activity?", "Is there a person whose endocrine system is actively involved in growth hormone and thyroid hormone regulation?", "Does the image show an individual likely to have frequent urination and bowel movements due to immature renal excretion?", "Can you identify someone whose cardiovascular system is adapting postnatally, such as with closure of fetal shunts or higher heart rates?", "Is there a subject with limited adaptive immune responses and increased susceptibility to infections?", "Does the image include an individual whose growth and development are driven by hormonal control and genetic regulation?", "Can you see someone whose thermoregulation depends on non-shivering mechanisms and limited peripheral vasoconstriction?", "Is there a person whose small intestine is specialized for efficient absorption of nutrients from milk?", "Does the image show an individual with immature alveolar structures in the lungs?", "Can you identify someone whose blood glucose regulation depends on hepatic glycogenolysis and limited gluconeogenesis?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show features consistent with the administration of a substance to outline the esophagus, stomach, or intestines on an X-ray?", "Does the image depict a diagnostic procedure involving the use of a radiopaque contrast agent?", "Is there a visible indication of a process designed to enhance the contrast of internal digestive structures for radiographic examination?"], "relational": ["Can you see anatomical pathways that begin at the oral cavity and continue through the pharynx and esophagus?", "Is there evidence of a substance outlining the lumen of the gastrointestinal tract?", "Does the image provide information about the function or structure of the gastrointestinal tract?"], "contexual_behavior": ["Is there a visible indication of a substance enhancing the contrast of internal digestive structures on the image?", "Can you identify evidence of a study that visualizes the gastrointestinal tract using imaging techniques?", "Does the image depict a diagnostic procedure involving the use of a radiopaque contrast agent?"], "functions": ["Does the image allow assessment of swallowing by showing the movement of a substance through the oropharynx or esophagus?", "Does the image provide information about motility or peristaltic activity in the digestive tract by showing the transit of a visible substance?", "Can you compare this image to previous ones to assess changes in lesions or structural abnormalities over time?"]}}, "pushing circumscribed borders": {"yes_questions": {"contexual_properties": ["Is there a lesion in the image that appears to expand in a cohesive, non-infiltrative manner, resulting in more pronounced and well-defined borders?", "Can you identify an area where the border of a lesion becomes less distinct, possibly indicating infiltration of surrounding tissue or tumor progression?", "Do you observe any changes in the thickness of a lesion's border that might suggest alterations in cellular proliferation or a stromal response?", "Is there evidence of irregular or uneven borders in a lesion that could be due to uneven growth or partial infiltration?", "Can you see a lesion whose border appears more elevated, possibly as a result of underlying tissue compression or outward growth?", "Does the image show a lesion with flattened borders, which might indicate reduced tumor pressure or regression?", "Are there visible color changes along the border of a lesion that could be attributed to hemorrhage, necrosis, or vascular changes?", "Do you observe an increase in the size of a lesion's border, suggesting cohesive expansion or enlargement?", "Is there a decrease in the size of a lesion's border that could be consistent with lesion shrinkage or a therapeutic response?", "Can you identify changes in the texture of a lesion's border, such as increased fibrosis, edema, or other cellular alterations?", "Is there a border that appears more fibrotic, possibly due to chronic inflammation or a stromal reaction?", "Do you see evidence of edema at the border of a lesion, which might result from increased vascular permeability or local inflammation?", "Are there areas of increased cellularity at the border of a lesion, suggesting active tumor proliferation or an inflammatory response?", "Can you find a lesion whose border is sharply demarcated, indicating well-circumscribed and non-infiltrative growth?", "Is there a border that has become less sharply demarcated, potentially due to infiltrative growth or tissue invasion?", "Do you observe any calcification at the border of a lesion, which could be a sign of dystrophic mineralization?", "Is there evidence of necrosis at the border of a lesion, possibly resulting from rapid growth or insufficient blood supply?", "Can you see changes in the composition of a lesion's border, such as alterations in cellular, stromal, or extracellular matrix components?", "Does the border of a lesion appear more compressible, which might be due to increased edema or reduced fibrous content?", "Is there a firmer border around a lesion, possibly resulting from increased fibrosis or collagen deposition?"], "properties": ["Does the image show a lesion with a rounded or oval outline?", "Can you identify an area with well-defined, sharply demarcated margins?", "Is there a structure whose borders are clearly separated from the surrounding tissue?", "Does the image contain a region with a smooth and regular contour?", "Can you see a lesion that appears pale or similar in color to adjacent tissue?", "Is there an area where the tissue appears firmer or denser than normal?", "Can you observe a structure with a uniform texture throughout?", "Is there a lesion whose thickness appears to be several millimeters to centimeters?", "Does the image show a region with minimal infiltration into the surrounding tissue?", "Can you identify an area that might contain densely packed neoplastic cells?"], "relational": ["Does the image show a mass that is clearly separated from the surrounding tissue without evidence of invasion?", "Can you identify a lesion that compresses but does not infiltrate adjacent normal parenchyma?", "Is there a structure with a well-demarcated interface from the surrounding tissue architecture?", "Does the image contain a nodule or cyst with a sharp margin rather than an irregular one?", "Can you see a mass that appears to be encapsulated or surrounded by a fibrous capsule?", "Is there evidence of compressed stroma or connective tissue at the periphery of a lesion?", "Does the image show an expansile growth pattern with cohesive cell nests at the border of a mass?", "Can you identify a lesion that separates itself from the host tissue or parenchyma?", "Is there a structure in the liver, breast, thyroid, kidney, or ovary that demonstrates a clear boundary from adjacent tissue?", "Does the image show a benign-appearing tumor or encapsulated neoplasm with compressed adjacent tissue?", "Can you see collagen bundles or a fibrous capsule outlining a mass?", "Is there a lesion whose border maintains a sharp distinction from the surrounding anatomical compartment?"], "contexual_behavior": ["Does the image show a boundary around a mass that appears less defined, suggesting possible invasion into the surrounding stroma?", "Is there evidence of a border that fails to contain tumor growth, indicating infiltrative or destructive behavior?", "Can you identify a border that appears more prominent, possibly due to localized inflammation or fibrotic encapsulation?", "Does the image reveal a boundary that seems disrupted, which could be due to rapid tumor proliferation or mechanical stress?", "Is there a border that appears less effective at preventing local tissue invasion, possibly under hypoxic conditions?", "Can you see signs of border disruption that might be associated with chronic inflammation or persistent inflammatory mediators?", "Does the border around a lesion appear particularly resistant to breakdown, suggesting dense collagen deposition or the presence of protease inhibitors?", "Is there a boundary that seems less effective or altered in an older individual, possibly due to tissue remodeling or reduced regenerative capacity?", "Can you observe changes in the border that might be related to anti-cancer therapy or alterations in the tumor microenvironment?", "Is there a well-defined, pronounced border around a mass, consistent with expansile growth typical of benign neoplasms and a lack of invasion into adjacent tissues?"], "functions": ["Does the image show a lesion with a well-defined margin that compresses but does not infiltrate surrounding tissues?", "Can you identify a mass with a smooth and rounded contour, suggesting an expansile growth pattern?", "Is there evidence of a structure that displaces neighboring tissues without penetrating them, resulting in a distinct boundary?", "Does the image contain a lesion that appears less aggressive, with features indicating reduced local tissue invasion?", "Can you see a mass that demonstrates a confined outward expansion, compressing adjacent structures but maintaining a clear separation?", "Is there a pathological process in the image that is sharply demarcated from normal tissue, aiding in diagnostic clarity?", "Does the lesion in the image exhibit a contained growth pattern, with a sharp interface between abnormal and normal tissues?", "Can you observe a structure where the interaction with surrounding tissue is limited by a defined margin, minimizing direct infiltration?"]}, "no_questions": {"contexual_properties": ["Is there evidence of calcification within a tumor, possibly indicating necrosis or tissue degeneration?", "Are papillary or finger-like projections visible along the wall of a cystic structure?", "Is there visual evidence suggesting abnormal biomarker expression, such as diagnostic staining or labeling?"], "properties": ["Is there a structure that appears to have both soft and firm regions, with a mixture of cystic and solid components?", "Is there a mass that could be classified as high-grade based on its features?", "Can you infer that the pH of the cystic fluid in the mass is mildly acidic to neutral, between 6.5 and 7.0?"], "relational": ["Can you see regional lymph nodes or lymphatic vessels in proximity to an abnormal mass?", "Is there evidence of connective tissue, adjacent organs, or serosal membranes surrounding a suspicious lesion?", "Are there visible blood vessels such as the ovarian artery, hepatic artery, or pancreatic arteries supplying a mass in the image?"], "contexual_behavior": ["Does the structure appear to be modifying its immune evasion strategies, such as by altering antigen presentation or expressing inhibitory ligands, possibly in response to immunotherapy?", "Is there evidence of increased metastatic spread, possibly associated with chronic inflammation or cytokine activity in the tumor microenvironment?", "Can you identify a region with enhanced blood vessel formation, possibly indicating angiogenesis under low oxygen conditions?"], "functions": ["Is there visual evidence of stromal cell activation, such as increased fibroblast presence or remodeling of the surrounding matrix?", "Can you see indications of local or systemic inflammation, such as increased immune cell presence or tissue swelling?", "Can you observe features suggesting tumor cell detachment or possible entry into blood vessels, which could indicate metastatic potential?"]}}, "bone marrow": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a tissue that is part of both the skeletal and hematopoietic systems?", "Can you identify a structure located within the femur, pelvis, sternum, vertebrae, or ribs?", "Is there a region containing specialized cells such as hematopoietic stem cells or megakaryocytes?", "Does the image display an area with abundant blood vessels like sinusoidal capillaries?", "Can you see a tissue surrounded by endosteum, compact bone, or spongy bone?", "Is there a structure protected by cortical bone or periosteum?", "Does the image reveal a tissue residing in the medullary cavity of a bone?", "Can you identify a region that interacts with organs such as the spleen, thymus, or lymph nodes in the process of blood cell formation?", "Is there a structure found in the axial skeleton, proximal ends of long bones, or pelvic girdle?", "Does the image show a tissue responsible for producing lymphocytes or other immune cells?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for hematopoiesis?", "Can you identify an area involved in immune cell production?", "Is there a region that serves as a storage site for stem cells?", "Does the image contain a tissue where erythrocytes, leukocytes, and platelets are produced?", "Can you see a structure that generates and matures lymphocytes, monocytes, or granulocytes?", "Is there evidence of a microenvironment supporting stem cell proliferation and differentiation?", "Does the image show a site where erythroid progenitor cells develop into red blood cells?", "Can you identify a location where neutrophils, eosinophils, or basophils might originate?", "Is there a structure responsible for platelet production through the maturation of megakaryocytes?", "Does the image contain a region that regulates blood cell levels by adjusting proliferation or apoptosis?", "Can you see a tissue that would increase white blood cell output in response to infection?", "Is there a structure supplying the body with both adaptive and innate immune cells?", "Does the image show an area that could replace damaged or lost blood cells through stem cell activation?", "Can you identify a region that stores hematopoietic or mesenchymal stem cells?", "Is there a structure that accelerates red blood cell and platelet production in response to blood loss?", "Does the image contain a tissue that increases erythropoiesis during anemia?", "Can you see a region where blood cell development is regulated by growth factors or cytokine signaling?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify an area where the temperature would be approximately 36.5 to 37.5\u00b0C?", "Does the image show a structure with an ovoid or ellipsoid shape?", "Does the image contain an object with an estimated volume of about 1.3 to 1.5 liters?"], "relational": ["Is there a region that includes the occipital, parietal, or frontal bones?", "Is there evidence of the middle ear cavity or paranasal sinuses in the image?", "Can you identify an area that might contain the tongue or salivary glands?"], "contexual_behavior": ["Is there a part that would increase metabolic demand during mental stress as neuronal activity and glucose consumption rise?", "Does the image contain a structure that could lose its ability to regulate temperature in the event of heatstroke due to hypothalamic dysfunction?", "Does the image show a region that could experience diminished reflex responses as neuronal degeneration progresses in neurodegenerative disease?"], "functions": ["Is there a part visible that enables communication through speech or facial expressions?", "Can you see evidence of a bony structure that safeguards neural tissue?", "Does the image reveal structures that contribute to speech production, such as the larynx, vocal cords, tongue, lips, or jaw?"]}}, "benign tumor": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a localized mass arising from tissues such as epithelium, connective tissue, muscle, or nervous tissue?", "Can you identify a well-demarcated structure within organs like the skin, brain, uterus, breast, or colon?", "Is there a mass composed of cell types such as epithelial cells, fibroblasts, adipocytes, or Schwann cells?", "Does the image contain a lesion adjacent to blood vessels, nerves, or surrounding parenchyma?", "Can you see a mass located within the integumentary, nervous, reproductive, or gastrointestinal systems?", "Is there a structure that appears to displace rather than infiltrate the surrounding tissue?", "Does the image show a lesion that is encapsulated or surrounded by a fibrous capsule?", "Can you identify a mass with clear anatomical boundaries, such as a basement membrane or organ capsule?", "Is there a localized growth present in regions like the head and neck, extremities, abdomen, or pelvis?", "Does the image show a structure with features such as slow growth, lack of invasion, and absence of metastasis?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that appears to be growing slowly and does not invade nearby tissues?", "Can you identify a mass that compresses or displaces surrounding anatomical structures without directly invading them?", "Does the image show a localized area of tissue enlargement with well-defined and possibly encapsulated borders?", "Is there evidence of a mass effect causing pressure or obstruction that could impair the function of a nearby organ?", "Can you see a structure with an expansive growth pattern that does not appear to infiltrate adjacent tissues?", "Is there a mass that might be compressing local blood vessels, potentially reducing blood flow to nearby tissues?", "Does the image reveal a well-circumscribed lesion that distorts normal tissue architecture by displacement rather than infiltration?", "Is there a structure that could be altering local cellular signaling, such as by producing growth factors affecting neighboring cells?", "Can you identify a mass that induces symptoms related to pressure on adjacent anatomical structures?", "Is there a lesion that appears to evade immune detection and does not cause widespread systemic disruption?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a surface that could potentially cover several hundred square centimeters, depending on the organ?", "Does the image show a layer with moderate protein content, possibly containing structural and functional proteins?", "Is there evidence of a tissue composed of simple squamous cells supported by connective tissue?"], "relational": ["Can you see a membrane that is continuous with the peritoneum?", "Can you identify a structure that forms the outermost layer of the stomach, small intestine, large intestine, or uterus?", "Is there a thin tissue layer supported by subserosa or loose connective tissue visible in the image?"], "contexual_behavior": ["Is there a region where increased permeability and immune cell infiltration might be seen during infection?", "Does the image show loss of normal tissue separation, possibly due to fibrin deposition and exudate accumulation during inflammation?", "Can you observe signs of impaired healing after injury, such as persistent inflammation or chronic tissue changes?"], "functions": ["Does the image show a structure that could participate in immune defense by housing immune cells within a body cavity?", "Can you identify a feature that maintains organ stability or prevents displacement within the cavity?", "Is there a thin membrane visible that provides a protective covering for internal organs?"]}}}
[ { "answer": "anencephaly", "extracted_concepts": [ "anencephaly" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "anencephaly" ], "question": "is anencephaly present?" }, { "answer": "anencephaly", "extracted_concepts": [ "anencephaly" ], "question": "what is present?" } ]	["anencephaly"]	{"anencephaly": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show an individual with a markedly reduced cranial size compared to normal?", "Is there evidence of microcephaly or a head circumference far below the expected range for gestational age?", "Can you identify a case where the cranial vault appears absent or severely underdeveloped, potentially exposing underlying tissue?", "Is there visible neural tissue that appears dark red to purple and has a friable, gelatinous texture?", "Does the image reveal disorganized or incomplete remnants of forebrain and midbrain structures?", "Can you see exposed neural tissue with a disorganized appearance and absence of the cerebrum?", "Is there a near-complete absence of skull bones in the cranial region?", "Does the brain tissue volume appear severely diminished, possibly limited to rudimentary brainstem structures?", "Is there evidence of malformed brainstem or primitive neural elements with no visible cerebral hemispheres?", "Can you infer from the image that the brain weight would likely be significantly below normal, possibly less than 100 grams?"], "relational": ["Does the image show absence or severe malformation of major structures such as the cerebral hemispheres or cranial vault?", "Is there a region of the head where the scalp appears missing or abnormal?", "Can you identify abnormalities affecting the forebrain or midbrain regions?", "Does the image reveal missing parts of the brain such as the cerebral cortex or cerebrum?", "Is there evidence of absent or malformed diencephalon in the cranial area?", "Are the bones of the skull or meninges visibly absent or disrupted?", "Can you see areas where neural tissue is exposed or not covered by cranial bone or skin?", "Is there a failure of cranial bone or overlying ectoderm development visible in the image?", "Does the image suggest a disruption in neural tube closure, particularly at the anterior end?", "Are there visible abnormalities in both the nervous and integumentary systems of the head?", "Can you identify regions where embryological structures such as the neural plate or neural folds may have failed to develop properly?", "Is the interface between the brain and skull altered, with evidence of exposed neural tissue?", "Does the upper facial region or calvaria appear structurally abnormal or incomplete?", "Is there a lack of normal scalp covering the cranial region?", "Are the skull bones missing or severely underdeveloped in the cranial area?"], "contexual_behavior": ["Does the image show evidence of a neural tube defect affecting the development of brain structures during early embryogenesis?", "Can you identify a fetus with malformation or absence of major brain regions that would disrupt central autonomic control?", "Is there a visible absence or severe underdevelopment of the forebrain and cerebrum, suggesting reduced neural control of vital physiological processes?", "Does the image indicate impaired coordination of fetal movement due to missing or underdeveloped motor cortex and neural circuits?", "Can you observe signs of failed sensory processing in the fetus, possibly due to missing sensory relay centers in the brain?", "Is there evidence of disrupted signaling between the brain and other organs, as might occur if neural pathways for inter-organ communication are absent?", "Does the image suggest abnormal regulation of heart rate or respiration that could result from a malformed or absent brainstem?", "Can you see indications that hypothalamic or pituitary structures have failed to develop, potentially affecting neurohormone production?", "Is there a decreased capacity for reflex responses in the fetus, possibly due to incomplete or absent neural circuits in the brain?", "Does the image show a lack of integration of neural pathways necessary for survival after birth, as would be expected if critical brain regions are missing?"], "functions": ["Does the image show an individual with severe malformation of the brain, particularly lacking the cerebral hemispheres and forebrain?", "Can you identify a case where neural regulation of vital physiological processes such as breathing and heart rate appears critically compromised?", "Is there evidence of profound sensory and motor deficits due to missing essential brain structures?", "Does the image suggest inadequate regulation of involuntary functions like blood pressure or digestion, indicating autonomic instability?", "Can you observe signs of impaired respiratory or cardiovascular regulation, such as respiratory failure or abnormal heart function?", "Is there an absence of normal reflexes or basic survival behaviors, possibly due to missing neural circuits in the brainstem or higher centers?", "Does the image indicate disruption of hormonal regulation or homeostasis, such as impaired hypothalamic or pituitary function?", "Can you see evidence of abolished movement coordination or postural instability, potentially due to absent cerebrum and cerebellum?", "Is there a complete lack of consciousness or cognitive function, as might be expected if the cerebral cortex is not developed?", "Does the image suggest a loss of communication between organ systems, possibly due to missing central neural pathways?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a large artery from which the coronary arteries, brachiocephalic trunk, left common carotid artery, or left subclavian artery branch off?", "Does the image display a vessel adjacent to the esophagus or vertebral column?", "Can you identify two major parallel vessels responsible for arterial outflow and venous return?"], "contexual_behavior": [], "functions": ["Is there a vessel that supplies blood to the coronary arteries via openings just above a heart valve?", "Can you identify a vessel that branches into major arteries supplying all regions of the body?", "Can you see a structure that receives blood during ventricular systole and releases it steadily during diastole?"]}}}
[ { "answer": "lymphangiomatosis", "extracted_concepts": [ "lymphangiomatosis" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "lymphangiomatosis" ], "question": "is lymphangiomatosis present?" }, { "answer": "lymphangiomatosis", "extracted_concepts": [ "lymphangiomatosis" ], "question": "what is present?" } ]	["lymphangiomatosis"]	{"lymphangiomatosis": {"yes_questions": {"contexual_properties": ["Does the image show any abnormal proliferation of lymphatic vessels?", "Can you identify regions with diffuse or multifocal lymphatic channel involvement?", "Is there evidence of a condition affecting multiple organs or tissues through lymphatic vessel overgrowth?", "Does the image reveal any widespread lymphatic abnormalities that could indicate a systemic disorder?"], "properties": ["Does the image show multiple masses that are diffuse throughout the tissue?", "Can you identify lesions that range in size from a few millimeters to several centimeters?", "Are there structures that appear translucent, pale, or yellowish in color?", "Is there evidence of tissue composed predominantly of lymphatic vessels and connective tissue?", "Do any of the visible lesions seem to contain fluid volumes in the milliliter to tens of milliliters range?", "Can you see masses that might have a low protein content in their fluid, similar to lymph?", "Are there areas with a cellular makeup including lymphatic endothelial cells, fibroblasts, or occasional inflammatory cells?", "Does the affected tissue appear to have lower density than surrounding normal tissue, possibly due to fluid-filled spaces?", "Are any of the lesions irregular or multiloculated in shape?", "Can you identify structures that might have a high water content, consistent with serous fluid?", "Is there evidence of tissue with low lipid content, except in regions that could contain chylous fluid?", "Do any of the lesions appear to have a soft, spongy, or cystic texture?", "Are there masses that seem to grow slowly and progressively over time?", "Can you see lesions that would be expected to have a neutral to slightly alkaline pH in their fluid?", "Are there areas with low vascularity, suggesting the presence of lymphatic rather than blood vessels?"], "relational": ["Does the image show evidence of abnormal changes within the lymphatic system?", "Can you identify any alterations in lymphatic vessels or connective tissue?", "Is there a visible abnormality affecting the respiratory or skeletal systems?", "Does the image reveal involvement of anatomical regions such as the thorax, abdomen, bones, or skin?", "Are there signs of altered lymphatic capillaries or collecting lymphatic vessels?", "Can you see any lesions present in the pleural or peritoneal cavity, or the mediastinum?", "Is there evidence of abnormal proliferation within lymphatic structures?", "Does the image show changes in organs like the lungs, liver, spleen, or bones?", "Are there visible abnormalities in tissues adjacent to blood vessels, nerves, or muscles?", "Can you identify any interactions between affected tissues and the circulatory, immune, or musculoskeletal systems?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal proliferation of vessels that could indicate multi-organ dysfunction?", "Can you identify any signs of vessel obstruction or malformation that might disrupt normal drainage?", "Is there visible fluid retention or swelling in tissues suggestive of impaired lymphatic function?", "Does the image display features consistent with impaired migration of immune cells due to blocked lymphatic pathways?", "Are there indications of excessive vessel growth or structural abnormalities affecting normal vessel function?", "Can you observe tissue swelling or edema that could result from poor lymphatic drainage?", "Is there evidence of impaired absorption of dietary fats, such as changes in intestinal structures responsible for chylomicron transport?", "Does the image suggest reduced clearance of waste products from tissues, possibly due to lymphatic dysfunction?", "Are there signs that immune surveillance might be decreased, such as limited movement of antigen-presenting cells or lymphocytes?", "Can you see features that would indicate increased interstitial fluid pressure resulting from disrupted drainage and fluid accumulation?"]}, "no_questions": {"contexual_properties": ["Can you observe cystic changes in a tube adherent to the ovary, as seen in hydrosalpinx or chronic salpingitis?", "Can you identify a tube near the ovary that looks swollen, which might indicate acute infection or an ectopic pregnancy?", "Is there evidence of fibrous tissue formation in a tube adherent to the ovary, possibly resulting from chronic inflammation and healing?"], "properties": ["Is there an object with a volume estimated between 0.5 and 1 milliliter?", "Does the image show a structure with a length of approximately 10 to 12 centimeters and a diameter of 1 to 4 millimeters?", "Is there a structure where fibrosis appears minimal under normal conditions?"], "relational": ["Is there a structure in the reproductive tract that communicates with the uterus at the uterine horn?", "Is there evidence of adhesion or physical attachment between a tubular structure and an ovary?", "Can you identify a tube-like structure in the pelvic region that is in direct contact with an ovary on the opposite side?"], "contexual_behavior": ["Is there evidence of a tube-like structure with narrowed or blocked lumen, suggesting possible impairment of fertilization due to inflammation or fibrosis?", "Can you identify a structure where ciliary movement might be altered, possibly as a result of pelvic inflammatory disease affecting the ciliated epithelium?", "Is there visual evidence of anatomical distortion or fibrosis in a tube-like structure, suggesting dysfunction possibly related to endometriosis?"], "functions": ["Does the image suggest disruption of the environment needed for fertilization, such as altered fluid secretion or microenvironment regulation, due to tube-ovary adhesion?", "Is there evidence of impaired ciliary motion or reduced motility in a tube adjacent to the ovary due to adherence?", "Can you see any indication of mechanical obstruction or altered function in a tube that could lead to infertility?"]}}}
[ { "answer": "yes", "extracted_concepts": [ "bilateral fractures" ], "question": "does this image show close-up bilateral fractures?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basilar skull fracture" ], "question": "is basilar skull fracture present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" } ]	["basilar skull fracture", "bilateral fractures"]	{"basilar skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a fracture involving the base of the skull, particularly in bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Is there a fracture line at the cranial base that appears less than a few millimeters wide?", "Does the image reveal a break limited to the thickness of the cranial base bones, typically only a few millimeters deep?", "Can you see a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Is there a lucent line traversing the base of the skull visible on the image?", "Does the image show an air-fluid level or evidence of pneumocephalus near the base of the skull?", "Can you identify any signs of cerebrospinal fluid leakage in association with a skull base fracture?", "Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Does the image suggest a unilateral fracture at the base of the skull, rather than a bilateral one?", "Is the temporal bone involved in the observed skull base fracture?", "Can you estimate whether the displacement of the fracture at the skull base is minimal, less than 2 millimeters?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?", "Are there air-fluid levels present near the base of the skull, as seen in about 20% to 30% of such fractures?", "On CT imaging, is there a hypodense (lucent) line at the base of the skull relative to the surrounding bone?", "Can you observe bruising patterns such as blue or purple discoloration behind the ear or around the eyes, which may change to yellow-green as they resolve?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Can you identify abnormalities in the anterior, middle, or posterior cranial fossae?", "Is there any indication of injury near the course of cranial nerves like the olfactory, optic, or facial nerves?", "Does the image reveal changes involving foramina such as the foramen magnum or cribriform plate?", "Are there visible alterations adjacent to the inner ear, nasal cavity, or orbit?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?", "Is there evidence of communication between the cranial cavity and spaces such as the subarachnoid space or paranasal sinuses?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Are there signs of disruption in sinuses such as the sphenoid or ethmoid sinus?", "Can you identify exposure or compromise of anatomical pathways like cerebrospinal fluid pathways or the auditory canal?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a disruption in the structural integrity of the skull base that could compromise brain protection?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Can you identify features suggesting a breach between the nasal cavity and cranial cavity, such as a defect in the cribriform plate?", "Does the image reveal any signs that could explain cranial nerve deficits, such as those affecting facial movement, hearing, vision, or swallowing?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?", "Can you see any indications that might increase the risk of infection entering the central nervous system, such as a direct pathway for pathogens?", "Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Are there features present that could facilitate the development of a cerebrospinal fluid leak due to openings in the dura mater or bone?", "Is there any sign of functional impairment, such as altered consciousness, seizures, or focal neurological deficits, that could be explained by a structural abnormality at the skull base?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify cells with an estimated lifespan of several months?", "Are there cells where water appears to constitute a significant portion of their mass, approximately 70\u201380%?", "Are there cells that appear pale eosinophilic or light pink under the microscope?"], "relational": ["Is there a cellular component present within the biliary system or hepatic lobule?", "Can you see anatomical connections to features like the Canals of Hering or portal triads?", "Can you identify cells located within the liver?"], "contexual_behavior": [], "functions": ["Is there evidence of a barrier protecting the biliary tract from toxins?", "Does the image display features consistent with secretion or absorption processes that regulate bile volume or composition?", "Can you see any indication of paracrine signaling or immune modulation between cells in the liver region?"]}}, "bilateral fractures": {"yes_questions": {"contexual_properties": ["Is there evidence of increased swelling or edema on both sides, suggesting an acute inflammatory response following injury?", "Can you identify areas where bone fragments appear displaced due to trauma or instability?", "Does the image show abnormal angulation or misalignment of bones on both sides, possibly due to inadequate reduction?", "Is there visible callus formation at the site of injury, indicating the reparative phase of bone healing?", "Are there signs of delayed healing, such as persistent fracture lines or lack of bridging bone, possibly due to impaired vascularity or infection?", "Can you observe bone shortening or overlapping fragments that might indicate loss of bone length during healing?", "Is there a visible deformity or malalignment present immediately after injury or persisting during healing?", "Does the image reveal areas of increased bone density at the fracture sites, consistent with the remodeling phase?", "Are there widened gaps between bone fragments, suggesting distraction or instability?", "Can you detect abnormal bone texture at the injury sites, which could indicate impaired healing or nonunion?", "Is there a change in alignment of bones on both sides, either immediately post-injury or during the healing process?", "Do you see increased bruising or hematoma formation in the soft tissues adjacent to the injury sites?", "Are there indications of abnormal mobility or instability at the fracture sites before healing or in cases of nonunion?", "Does the image show disruption or loss of continuity in the bone structure on both sides?", "Is there evidence of periosteal reaction, such as new bone formation along the periosteum, during the early reparative phase?", "Can you identify features suggesting nonunion or malunion, such as persistent fracture lines or bones healing in incorrect alignment?", "Are there signs of limb length discrepancy, possibly due to bone shortening or malunion during healing?", "Do you observe soft tissue swelling adjacent to both injury sites, consistent with acute inflammation?", "Is there increased radiolucency at the fracture sites, indicating early stage healing or delayed union?", "Can you see narrowing of joint spaces near the fracture sites, suggesting articular involvement or post-traumatic changes?"], "properties": ["Does the image show injuries affecting both members of a paired bone, such as both femurs or both tibiae?", "Can you identify fractures in paired long bones like the humeri or femurs?", "Is there evidence of bone breaks with an affected segment length between 5 and 15 centimeters on both sides?", "Does the image reveal fracture gaps measuring approximately 2 to 5 millimeters in width?", "Can you observe displacement at the fracture sites measuring between 1 and 3 centimeters?", "Are there fracture patterns present that appear transverse, oblique, or comminuted in paired bones?", "Does the image suggest a moderate to severe grade of injury in both corresponding bones?", "Is there visual evidence of reduced bone density or osteopenia at the sites of paired fractures?", "Do the fractures appear as linear or irregular lines in both affected bones?", "Can you see swelling near the fracture sites measuring around 3 to 6 centimeters?", "Are the paired fractures located in bones such as the tibia, femur, or radius?", "Is there an observable angulation at the fracture sites between 5 and 20 degrees?", "Does the image suggest the possibility of slightly elevated temperature (37.5\u201338.5\u00b0C) at the sites of injury?", "Can you estimate whether the blood loss associated with the observed fractures could be in the range of 500 to 1500 milliliters?", "Does the image suggest that the injuries are more likely to occur in young adults or elderly individuals?"], "relational": ["Does the image show disruption of bone integrity on both sides of the body in corresponding bones?", "Can you identify fractures involving paired bones such as femurs, tibiae, humeri, radius, or ulnae on both the left and right sides?", "Is there evidence of injury affecting both upper or both lower limbs simultaneously?", "Does the image display fractures in regions like the pelvis, ribs, or clavicles on both sides?", "Are there visible signs of musculoskeletal system disruption involving symmetrical bones?", "Can you see anatomical structures adjacent to fracture sites, such as muscles, blood vessels, nerves, or ligaments, on both sides?", "Is there involvement of joints like the knee, elbow, hip, shoulder, wrist, or ankle on both the left and right sides due to fractures?", "Does the image show surrounding tissues\u2014such as skeletal muscle, subcutaneous tissue, periosteum, skin, or fascia\u2014affected near symmetrical fracture sites?", "Are both appendicular or both axial skeletal segments involved in the observed injuries?", "Can you identify anatomical landmarks such as the greater trochanter, medial malleolus, olecranon, acromion, or epicondyles associated with fractures on both sides?", "Is there evidence of soft tissue injury, vascular injury, nerve damage, or compartment syndrome occurring in conjunction with symmetrical bone injuries?"], "contexual_behavior": ["Does the image show injuries affecting corresponding bones on both sides of the body, potentially leading to more severe mobility limitations than if only one side were involved?", "Can you identify evidence of trauma to both limbs that might limit compensatory movement and ambulation?", "Is there visual indication of impaired healing capacity due to increased physiological stress or reduced vascular supply at two symmetrical injury sites?", "Does the image suggest disruption of blood circulation in both affected limbs, such as swelling or vascular compromise on both sides?", "Can you observe signs of decreased muscle function or immobilization affecting muscle groups bilaterally?", "Is there evidence of extensive tissue damage on both sides that could trigger a systemic inflammatory response?", "Does the image show both limbs unable to support body weight, indicating compromised weight-bearing ability under physical stress?", "Can you see signs that suggest both sides require prolonged immobilization, potentially delaying functional recovery during rehabilitation?", "Is there visual evidence that both limbs are nonfunctional, which could significantly impair daily activities and self-care?", "Does the image indicate instability or weakness on both sides of the body, potentially affecting balance and postural control?", "Can you identify signs of nerve impairment, such as swelling or trauma, in both affected regions?", "Is there evidence of immobility and vascular injury on both sides that could increase the risk of deep vein thrombosis?", "Does the image suggest that both limbs are immobilized, potentially decreasing the capacity for self-care and independence?", "Can you observe multiple injury sites that would require simultaneous bone repair, increasing metabolic demand for healing?", "Is there indication of pain or discomfort originating from both injured regions, which could exacerbate pain perception and complicate pain management?", "Does the image show bilateral dysfunction that would impair the body's ability to compensate for injury during movement?"], "functions": ["Does the image show injuries on both sides of the body that could lead to significant loss of function or disability?", "Is there evidence of trauma affecting paired limbs, resulting in reduced mobility or difficulty with ambulation?", "Can you identify damage to both limbs that would make weight-bearing activities difficult or impossible?", "Does the image suggest decreased strength, range of motion, or dexterity in both affected limbs?", "Is there visual indication that the healing process might be prolonged due to injuries on both sides?", "Can you see signs that muscle coordination could be disrupted because compensatory mechanisms are limited?", "Does the image imply that rehabilitation would be more complex or require extended therapy due to injuries on both sides?", "Is there evidence that daily living activities might be significantly hindered, leading to increased dependency on assistance?", "Can you identify features suggesting compromised balance or an increased risk of falls and instability?", "Does the image show injuries that could elevate the risk of complications such as immobility, pressure ulcers, or infection due to reduced movement?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of a tumor arising from the epithelial lining within the gastrointestinal tract?", "Does the image show a malignant process affecting the gastrointestinal system?", "Is there a structure whose relationship to the colon wall layers can be visually assessed for invasion or disruption?"], "contexual_behavior": [], "functions": ["Can you see evidence of changes in the tumor microenvironment, such as fibrosis or altered immune cell distribution?", "Does the image show a region with evidence of uncontrolled cellular growth or invasion into surrounding tissues?", "Does the image display features consistent with new blood vessel formation, possibly indicating angiogenesis?"]}}}
[ { "answer": "opened skull looking into foramina magna single fused calvarium twins with separate brainstems", "extracted_concepts": [ "opened skull", "separate brainstems", "foramina magna", "twins", "single fused calvarium" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "opened skull", "separate brainstems", "foramina magna", "twins", "single fused calvarium" ], "question": "does this image show opened skull looking into foramina magna single fused calvarium twins with separate brainstems?" }, { "answer": "cephalothoracopagus janiceps", "extracted_concepts": [ "cephalothoracopagus", "janiceps" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "cephalothoracopagus janiceps" ], "question": "is cephalothoracopagus janiceps present?" }, { "answer": "cephalothoracopagus janiceps", "extracted_concepts": [ "cephalothoracopagus", "janiceps" ], "question": "what is present?" } ]	["opened skull", "janiceps", "separate brainstems", "cephalothoracopagus janiceps", "foramina magna", "cephalothoracopagus", "twins", "single fused calvarium"]	{"opened skull": {"yes_questions": {"contexual_properties": ["Is there evidence of increased bleeding that could suggest trauma, vascular injury, or a problem with blood clotting?", "Can you observe swelling of tissues that might indicate inflammation, infection, or fluid accumulation within the cranial cavity?", "Is there any discoloration of bone that could be due to hemorrhage, bruising, or a chronic bone disorder?", "Do you see areas where the bone texture appears abnormal, possibly consistent with osteoporosis, infection, or tumor infiltration?", "Is there visible thinning of bone that might be associated with osteoporosis, long-term steroid use, or a metabolic bone disorder?", "Can you identify regions of bone thickening that could suggest Paget\u2019s disease, chronic infection, or hyperostosis?", "Are there any fractures or cracks present that might be the result of blunt force, weakened bone, or surgical intervention?", "Do you notice any accumulation of fluid that could indicate a subdural hematoma, abscess, or leakage of cerebrospinal fluid?", "Is there abnormal tissue growth visible that could correspond to a tumor, granuloma, or meningioma?", "Can you detect changes in bone density that might be caused by a metabolic bone disorder, malignancy, or chronic infection?", "Are there signs of infection such as pus or redness that could be due to osteomyelitis, meningitis, or a scalp infection?", "Is there evidence of bone softening that might suggest rickets, osteomalacia, or chronic infection?", "Do you observe erosion of the bone surface that could be caused by chronic infection, tumor invasion, or pressure from a nearby mass?", "Is there abnormal coloration of the meninges that could indicate meningeal hemorrhage, infection, or chemical irritation?", "Can you see any effects that might suggest increased intracranial pressure, such as swelling from cerebral edema, a mass lesion, or hydrocephalus?"], "properties": ["Is there a structure in the image that measures approximately 20 to 25 centimeters in length and 15 to 20 centimeters in width?", "Can you identify an object that would weigh around 1.2 to 1.5 kilograms in adults?", "Does the image show something with an oval or rounded shape and a domed vault?", "Is there a bone present that appears off-white to pale yellow in color?", "Can you see a structure where the bone thickness ranges from 4 to 8 millimeters depending on the region?", "Is there an object with a smooth inner surface and a slightly rough outer surface?", "Does the image contain a structure composed mainly of hydroxyapatite, collagen, and water?", "Can you identify a bone with a density of about 1.5 to 2.0 grams per cubic centimeter?", "Is there a cavity visible that could hold approximately 1200 to 1500 milliliters in volume?", "Does the bone in the image appear to have a water content of roughly 10 to 20 percent by weight?", "Is there a structure where calcium phosphate accounts for about 60 to 70 percent of its mass?", "Can you see an object that would likely be at room temperature, around 20 to 25 degrees Celsius, during examination?", "Is there a bone present with a slightly alkaline pH, typically between 7.2 and 7.4?", "Does the image show a structure with moderate porosity, featuring cancellous bone between compact layers?", "Can you identify a surface area within the cranial vault estimated to be about 800 to 900 square centimeters in adults?"], "relational": ["Does the image show anatomical structures such as the brain or its protective membranes exposed?", "Can you identify separated cranial bones like the frontal, parietal, temporal, or occipital bones?", "Is there visual evidence of membranes such as dura mater, arachnoid mater, or pia mater?", "Does the image reveal regions of the brain like the cerebral cortex, cerebellum, or brainstem?", "Are cranial cavities such as the anterior, middle, or posterior cranial fossae visible?", "Can you see blood vessels like the middle meningeal artery, superior sagittal sinus, or cerebral veins?", "Is there direct exposure of the meninges that cover and protect the brain?", "Are adjacent facial or cranial structures such as the orbits, nasal cavity, zygomatic bones, or mandible present near the exposed area?", "Does the image show anatomical layers traversed, including the scalp, periosteum, skull bones, and meninges?", "Are parts of the nervous system such as the cerebrum, cerebellum, cranial nerves, or brainstem accessible in the image?"], "contexual_behavior": ["Does the image show evidence of cranial exposure that could increase the risk of brain infection from external pathogens?", "Is there a visible breach in the protective barriers of the head, such as the skull and meninges?", "Can you identify a situation where the regulation of intracranial pressure might be disrupted due to loss of the cranial vault's rigidity?", "Is there a region where the brain appears less protected against mechanical shocks because bony structures are missing or compromised?", "Does the image suggest possible leakage of cerebrospinal fluid due to disruption of the dura mater or other meningeal layers?", "Is there any indication of exposed vascular structures that could increase the risk of bleeding or impaired hemostasis?", "Can you see an area where the brain is directly vulnerable to environmental toxins due to loss of natural barriers?", "Does the image reveal a defect that could lead to abnormal heat loss or disrupted thermoregulation of brain tissue?", "Is there evidence that the brain's metabolic stability or homeostasis might be affected by exposure to the external environment?", "Can you identify features suggesting that the immune response within the cranial cavity could be altered due to a barrier breach?", "Does the image show a scenario where physiological regulation and homeostasis might be impaired during a surgical procedure due to loss of protective barriers?", "Is there visible exposure of blood vessels that could increase the risk of hemorrhage during trauma?", "Can you see signs that the effectiveness of the blood-brain barrier may be reduced due to structural disruption?", "Does the image suggest changes in cerebral blood flow dynamics as a result of altered intracranial pressure or loss of cranial enclosure?", "Is there evidence that the brain's defense against pathogens could be impaired during an open neurosurgical procedure because natural barriers are bypassed?"], "functions": ["Does the image show a situation where intracranial contents are directly exposed?", "Is there evidence of a loss of the protective barrier that normally surrounds the brain?", "Can you identify a scenario where the brain appears more vulnerable to external injury?", "Does the image suggest disruption of homeostatic pressure maintenance within the cranial cavity?", "Is there a visible indication that immune defense mechanisms for the brain might be compromised?", "Can you see signs that the regulation of intracranial pressure could be impaired due to the absence of a rigid enclosure?", "Does the image depict a context where direct access to intracranial structures for surgical intervention is possible?", "Is there visual evidence of instruments or visualization of brain tissue that would enable precise manipulation?", "Can you identify features that indicate an increased risk of trauma or infection to neural tissue?", "Does the image suggest the possibility of cerebrospinal fluid leakage or instability in pressure that would not occur with an intact cranium?", "Is there a scenario where the risk of central nervous system infection appears elevated due to loss of a protective barrier?", "Can you see signs that the brain\u2019s ability to buffer mechanical injury or maintain physiological stability is reduced?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify anatomical variations such as an anomalous right coronary artery or an interarterial course of a coronary vessel?", "Can you identify a vessel supplying the left ventricle or left atrium that appears to originate from the pulmonary artery rather than the ascending aorta?", "Is there evidence of a coronary artery arising from the pulmonary artery instead of the left aortic sinus?"], "contexual_behavior": [], "functions": ["Is there a vessel originating from the pulmonary artery that appears to supply deoxygenated blood to the heart muscle?", "Is there evidence of features that could impair the heart\u2019s response to stress or increased workload, potentially increasing the risk of arrhythmias or sudden cardiac arrest?", "Does the image show evidence of a structure that could lead to reduced oxygenated blood supply to the myocardium, potentially resulting in myocardial ischemia or heart failure?"]}}, "janiceps": {"yes_questions": {"contexual_properties": ["Does the image show evidence of asymmetrical head size during embryonic or fetal development?", "Can you identify abnormal cranial structures that might result from incomplete cranial division in the prenatal period?", "Is there a visible fusion of facial features suggestive of craniofacial abnormality during early gestation?", "Does the image display differences in skull composition, such as variable degrees of fusion or ossification during fetal growth?", "Can you observe variation in neural tissue development that could be influenced by the degree of cranial fusion in utero?", "Is there a detectable change in head circumference that might be identified by prenatal imaging due to partially fused heads?", "Does the image reveal altered bone density in the skull, possibly resulting from abnormal bone formation and fusion during embryonic development?", "Can you see abnormal skin coloration on the heads at birth that could indicate vascular anomalies?", "Is there evidence of tissue or organ duplication that might have occurred during organogenesis as a result of twinning?", "Does the image show changes in the size of shared organs that could be attributed to developmental constraints from conjoined anatomy?"], "properties": ["Does the image show an individual with a head size that appears larger than average due to craniofacial duplication?", "Can you identify a newborn whose weight seems higher than typical for singletons, possibly exceeding 4 kilograms?", "Is there a broad and rounded cranial shape suggestive of bifacial cranium or cranial widening?", "Does the image depict two distinct sets of facial features, each on opposite sides of the head?", "Can you observe evidence of partial brain duplication or fused cerebral hemispheres within the cranial region?", "Is the skin color of the neonate consistent with normal variation for their genetic background?", "Does the length of the newborn appear within the typical range of 45 to 55 centimeters?", "Are there four eyes visible, with two eyes present on each face?", "Can you see two mouths, each corresponding to a separate set of facial features?", "Are there four ears present, with two ears per face?", "Do the facial features appear to be arranged symmetrically on opposite sides of the head?", "Is there a single, centrally located neck supporting both sets of facial features?", "Can you identify duplicated facial bones or partially fused cranial vault bones in the head structure?", "Does the distance between the two faces correspond to the width of the shared cranium?", "Are the facial features arranged in a mirror-image pattern across the sagittal plane?"], "relational": ["Does the image show a single head with two complete faces oriented in opposite directions?", "Can you identify a structure where the cranium is fused but facial features such as eyes, noses, and mouths are duplicated?", "Is there evidence of two sets of orbits, nasal cavities, and mandibles present on one skull?", "Does the image contain duplicated cranial structures, such as two brains or two sets of upper respiratory organs, within a shared torso?", "Can you see a region where the frontal, temporal, or occipital areas of the head appear structurally altered due to facial duplication?", "Is there a visible connection between two faces by shared cranial bone and soft tissue?", "Does the image depict a form of conjoined twinning characterized by craniofacial duplication rather than fusion at the thorax or pelvis?", "Are there duplicated facial bones, such as maxillae and zygomatic bones, present on a single fused cranium?", "Can you observe two faces affecting the head, neck, and upper thorax regions in the image?", "Is there a structure in the image where organ systems in the torso appear shared, but cranial features are duplicated?"], "contexual_behavior": ["Does the image show an individual with two heads that might have difficulty coordinating movement or integrating sensory information?", "Can you identify signs of altered breathing patterns that could result from shared thoracic structures or malformed thoracic organs?", "Is there evidence of reduced cardiac efficiency, such as signs of physical stress, that could be related to duplicated or fused cardiovascular anatomy?", "Does the image depict abnormal feeding behavior, possibly due to both mouths attempting to feed at the same time or interference between oral structures?", "Can you observe features that might indicate difficulty in regulating body temperature, such as duplicated heads or increased surface area?", "Is there any indication of compromised locomotor function, such as impaired coordination between two heads and shared musculoskeletal structures?", "Does the image suggest problems with swallowing or airway protection that could arise from duplicated pharyngeal or laryngeal structures?", "Can you see signs of altered metabolic activity, such as increased tissue mass or duplicated organs, that might affect energy balance?", "Is there visual evidence of increased risk of infection, possibly due to shared or fused organ systems that could facilitate pathogen transmission?", "Does the image suggest a failure to coordinate sensory input between two heads, such as conflicting responses to external stimuli?"], "functions": ["Does the image show a developmental anomaly characterized by craniofacial duplication?", "Can you identify evidence of conjoined twinning involving two faces on a single head?", "Is there visual indication of duplication or fusion of cranial and neural structures?", "Does the image reveal abnormalities that could disrupt normal physiological processes in the head or brain?", "Can you observe features suggesting shared or duplicated brain, airway, or vascular systems?", "Is there evidence of structural fusion that might impair organ function?", "Does the image display abnormal vascular connections or duplications in the head and neck region?", "Can you identify signs of circulatory compromise or hemodynamic instability related to vascular anomalies?", "Is there visual evidence of two brains or partially fused neural tissue that could affect neural coordination?", "Does the image suggest impaired or uncoordinated neural control due to neural fusion or brain duplication?", "Can you observe abnormal airway anatomy, such as duplicated or obstructed respiratory passages?", "Is there indication of respiratory compromise or pulmonary dysfunction due to airway malformation?", "Does the image show features that could disrupt metabolic regulation, such as duplicated or fused hypothalamic regions?", "Can you identify signs of endocrine disruption or hypothalamic anomaly that might affect metabolic balance?", "Is there evidence of duplicated or fused sensory organs or neural pathways that could alter sensory integration?", "Does the image suggest abnormal perception or processing due to sensory duplication or neural integration deficit?", "Can you observe oral or pharyngeal malformations that might hinder effective swallowing or feeding?", "Is there visual indication of digestive impairment or feeding difficulty related to abnormal oral structures?", "Does the image reveal signs of disrupted central nervous system control over vital functions?", "Can you identify features that might lead to homeostatic instability, such as temperature, fluid, or metabolic imbalance?"]}, "no_questions": {"contexual_properties": ["Are there abnormal cell shapes present, which could be associated with dysplasia or certain genetic disorders?", "Does the tissue thickness appear altered, possibly due to hyperplasia or atrophy?", "Do you notice changes in tissue color that might result from pigment deposition or altered blood content?"], "properties": ["Is there evidence of basophilic nuclei and eosinophilic cytoplasm after standard staining?", "Do the tissue sections appear pink and purple, consistent with hematoxylin and eosin staining?", "Are prominent organelles such as nuclei, nucleoli, and mitochondria visible within the cells?"], "relational": ["Can you distinguish layers such as mucosa, submucosa, muscularis, or serosa within the tissue?", "Is there connective tissue present, indicated by collagen fibers, elastic fibers, ground substance, or extracellular matrix?", "Is there evidence of organs such as the liver, kidney, heart, lung, or skin being examined?"], "contexual_behavior": ["Is there a region where epithelial integrity or tight junctions seem compromised, indicating impaired barrier function in response to infection?", "Is there evidence of immune-mediated tissue destruction that disrupts physiological balance, indicating a failure to maintain homeostasis in an autoimmune condition?", "Does the image show evidence of tissue where immune cell infiltration or edema has disrupted the normal architecture, suggesting an inflammatory response?"], "functions": ["Can you see signs of balanced cell turnover or a stable microenvironment that would indicate tissue homeostasis?", "Is there a visible structural niche that could support immune cell surveillance within the tissue?", "Can you identify a region where cells and extracellular matrix appear coordinated, suggesting support for vital physiological processes?"]}}, "separate brainstems": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears swollen, which could indicate edema or inflammation?", "Is there an area that looks reduced in size, suggesting possible atrophy or chronic neurodegenerative disease?", "Can you identify a region with abnormal coloration, such as darkening or pallor, that might result from hemorrhage or hypoxia?", "Is there evidence of abnormal tissue composition, such as masses or irregular textures, that could be associated with tumors or demyelinating diseases?", "Does the image reveal a structure that appears compressed by an adjacent mass or shows signs of displacement?", "Is there an area with increased vascularity, such as prominent blood vessels, which might be seen in neoplasms or vascular malformations?", "Can you observe features consistent with edema, such as diffuse swelling or blurred margins, possibly due to acute injury or infection?", "Is there a region that appears atrophic, with thinning or shrinkage, as seen in progressive neurological disorders?", "Does the image display lesions or focal abnormalities that could be related to demyelinating diseases or vascular insults?", "Can you see changes in texture, such as areas that look fibrotic, necrotic, or cystic?", "Is there visible fluid accumulation, such as cystic spaces or swelling, that might indicate edema or obstructed cerebrospinal fluid flow?", "Are there signs of demyelination, such as patchy or irregular signal changes, that could be due to autoimmune or infectious diseases?", "Does the structure appear softer or firmer than surrounding tissue, suggesting necrosis, fibrosis, or calcification?", "Can you identify regions of hemorrhage, such as localized bleeding or darkened areas, possibly following trauma or vascular rupture?", "Is there evidence of calcification, such as bright or dense spots, which could result from chronic infection or metabolic disorders?", "Does the image show abnormal cell densities, such as areas of infiltration or increased cellularity, that might indicate neoplastic or inflammatory processes?", "Are there signs of compromised structural integrity, such as fragmentation or loss of normal architecture, following severe trauma or infarction?", "Can you observe displacement of a structure due to mass effect or herniation from an expanding lesion?", "Is there evidence of altered metabolic activity, such as regions that appear unusually bright or dark, which could be associated with tumors or degenerative diseases?", "Does the image display abnormal imaging signals, such as hyperintense or contrast-enhancing areas, that might indicate infarction, demyelination, or neoplastic infiltration?"], "properties": ["Does the image show a structure that is cylindrical or elongated with slight tapering?", "Can you identify an object that measures between 7 and 9 centimeters in length?", "Is there a structure present with a width of about 2 to 2.5 centimeters?", "Does the image contain an object weighing approximately 25 to 30 grams?", "Can you see a structure with a volume close to 15 to 20 cubic centimeters?", "Is there a pale white to light gray structure visible?", "Does the image include a region where neurons, astrocytes, oligodendrocytes, and microglia are likely to be found together?", "Can you identify an area with moderate myelin content, indicating both myelinated and unmyelinated fibers?", "Is there a structure where the ratio of gray matter to white matter is roughly equal?", "Does the image show an object that would typically have a water content of about 78 to 80 percent by weight?", "Can you see a region with a density close to 1.04 grams per cubic centimeter?", "Is there a structure that would be expected to have a pH between 7.1 and 7.3?", "Does the image include an area likely to be at core body temperature, around 36.5 to 37\u00b0C?", "Is there a structure where neurotransmitters such as serotonin, dopamine, norepinephrine, acetylcholine, and glutamate are present?", "Can you identify an object composed mainly of structural proteins, enzymes, and neurotransmitter-related proteins?", "Is there a region with a lipid content of about 10 to 12 percent by weight?", "Does the image show a structure with a glucose concentration typically between 2 and 4 millimoles per liter?", "Can you see an area where the oxygen level is maintained at about 20 milliliters per 100 grams of tissue?", "Is there a structure with an iron concentration of approximately 30 to 50 micrograms per gram of tissue?"], "relational": ["Does the image show a structure that is part of the central nervous system?", "Can you identify a region that includes the midbrain, pons, or medulla oblongata?", "Is there a structure that connects to the cerebellum or spinal cord?", "Does the image contain an area associated with cranial nerves III through XII?", "Can you see a part of the nervous system adjacent to the cerebrum or cerebellum?", "Is there a structure whose boundaries are defined by the foramen magnum or tentorium cerebelli?", "Does the image show a region near the fourth ventricle?", "Can you identify an area supplied by the basilar artery or vertebral arteries?", "Is there a structure that is continuous with the spinal cord at the medullary-spinal junction?", "Does the image show tissue surrounded by meninges or cerebrospinal fluid?", "Can you see a structure located within the cranial cavity?"], "contexual_behavior": ["Is there evidence of a structure that could be involved in impaired coordination of autonomic functions, such as might occur in congenital malformations or after trauma?", "Can you identify an area that might alter its control of breathing during sleep, as seen in central sleep apnea or following a lesion?", "Does the image show a region that could have reduced ability to regulate heart rate under stress, as in dysautonomia or after injury?", "Is there a structure that might fail to synchronize motor responses during movement, possibly due to developmental anomalies or neurodegenerative conditions?", "Can you see an area that would increase its activity in response to hypoxia or low oxygen availability?", "Is there a region that might decrease its responsiveness to sensory input during anesthesia?", "Does the image contain a structure that could show altered reflex control in neurodegenerative diseases such as ALS or MSA?", "Can you identify an area that might lose its capacity to maintain consciousness after severe trauma or stroke?", "Is there a region that could change its regulation of swallowing during neurological disorders like bulbar palsy or multiple sclerosis?", "Does the image show a structure that might exhibit impaired temperature regulation in extreme environments due to disrupted hypothalamic integration?", "Is there an area that could enhance its role in arousal during acute stress by activating the reticular activating system?", "Can you identify a region that might reduce its function in coordinating eye movements during fatigue?", "Does the image show a structure that could fail to modulate pain perception in chronic pain conditions?", "Is there an area that might alter its control of blood pressure during orthostatic changes, as seen in autonomic failure or baroreflex impairment?", "Can you see a region that could show decreased neurotransmitter release in conditions such as Parkinson\u2019s disease due to degeneration of dopaminergic neurons?"], "functions": ["Does the image show structures responsible for autonomic regulation, such as controlling breathing and heart rate?", "Can you identify regions that would house centers generating rhythmic breathing patterns?", "Is there evidence of anatomical areas that modulate autonomic output to the heart?", "Does the image contain structures that could integrate sensory input and motor output for reflexes like swallowing or gagging?", "Are there regions that support arousal and alertness, possibly through the reticular activating system?", "Can you see pathways that would transmit motor signals between the brain and spinal cord?", "Does the image show structures involved in relaying sensory information from peripheral nerves to higher brain centers?", "Are there areas that could integrate signals influencing sleep cycles and wakefulness?", "Can you identify regions that might control sympathetic and parasympathetic outputs to organs?", "Does the image show structures that integrate vestibular and proprioceptive inputs for maintaining balance and posture?"]}, "no_questions": {"contexual_properties": ["Is there visual evidence that could correspond to significant maternal blood loss, such as anemia or hypovolemia?", "Is there visible damage to placental tissue, such as infarcts, hemorrhages, or disrupted areas?", "Does the image indicate a drop in maternal blood pressure, possibly due to acute blood loss?"], "properties": ["Is there visual evidence of acute changes near the placenta that could have developed over minutes to hours?", "Can you see a dark red or maroon area suggestive of accumulated blood near the placenta?", "Does the image suggest a partial or complete separation of the placenta from the uterine wall?"], "relational": ["Can you observe any impact on fetal structures like the chorionic villi or umbilical cord?", "Does the image show alterations in the anatomical connection between the placenta and the uterine wall?", "Does the image reveal disruption at the placental implantation site on the uterine wall?"], "contexual_behavior": ["Is there visual evidence of decreased hormone production or endocrine dysfunction at the maternal-fetal interface due to structural separation?", "Can you identify features suggesting compromised fetal growth or restricted development, possibly resulting from chronic insufficiency of a structure responsible for nutrient and oxygen delivery?", "Does the image show signs of impaired maternal cardiovascular stability, such as hypovolemia or shock, that could be associated with significant blood loss from a detached structure?"], "functions": ["Does the image show evidence of placental separation that could lead to fetal distress or maternal hemorrhage?", "Are there visual cues of physiological responses such as uterine tenderness or signs suggestive of shock?", "Is there evidence of conditions that could increase the risk of preterm birth or perinatal mortality due to fetal hypoxia?"]}}, "cephalothoracopagus janiceps": {"yes_questions": {"contexual_properties": ["Does the image show a case of conjoined twins with a shared head and thorax?", "Is there evidence of two faces oriented in opposite directions on a single head?", "Can you identify a condition where two individuals are fused at the upper body and head regions?", "Does the image depict a rare congenital anomaly involving duplication of facial structures on a shared cranium?"], "properties": ["Does the image show a case where two individuals are conjoined at both the head and the chest regions?", "Can you identify a situation where two faces are present on opposite sides of a shared head?", "Is there evidence of duplicated cranial or facial structures within a single fused upper body?", "Does the image depict a fusion of two bodies with a single head exhibiting two faces?"], "relational": ["Does the image show two faces that appear duplicated on a single upper body?", "Can you identify a continuous anatomical connection between the head and chest regions?", "Is there evidence of fusion between the cranial and thoracic areas?", "Does the image display a structure where the rib cage and sternum are shared by two heads?", "Can you see signs of a fused cranium or joined brain structures?", "Is there a visible joining of the skull base, cervical vertebrae, or thoracic spine?", "Does the image suggest the presence of shared thoracic organs such as the heart or liver?", "Are there duplicated facial features with a single thoracic region beneath them?", "Can you observe major arteries or veins, such as carotid arteries or jugular veins, that are shared between two head regions?", "Is there a clear anatomical boundary at the cranial vault or lower thoracic margin indicating fusion?", "Does the image show upper body regions that are fused while lower abdominal organs appear separated?", "Can you identify a structure affecting the respiratory, cardiovascular, or digestive systems due to fusion of the upper body?"], "contexual_behavior": ["Does the image show an individual with two heads that may have impaired coordination between them?", "Is there evidence of anatomical fusion in the thoracic region that could indicate shared heart or major vessels?", "Can you identify features suggesting that both heads might rely on a single or partially shared respiratory system?", "Does the image display duplicated or malpositioned oral or digestive structures that could affect feeding efficiency?", "Is there a shared body mass or surface area that might disrupt normal heat exchange and thermoregulation?", "Can you see signs of fused or malformed renal or gastrointestinal tracts that could impair waste elimination?", "Does the image suggest the presence of shared vascular structures that might alter circulatory dynamics during physical activity?", "Are there anatomical features indicating a shared lymphatic or hematopoietic system that could compromise immune defense?", "Can you identify shared respiratory or circulatory systems that might limit oxygen delivery during anesthesia or surgical intervention?"], "functions": ["Does the image show individuals with evidence of shared cranial or thoracic organs, suggesting systemic interdependence?", "Can you identify anatomical features indicating fusion of heads and upper bodies that might disrupt coordination of vital organ functions?", "Is there visual evidence of shared or partially fused airways or thoracic cavities that could compromise respiratory function?", "Does the image reveal the presence of conjoined hearts or major vessels that might affect circulatory system regulation?", "Can you observe duplicated or fused brain structures that could impair neural integration or sensory processing?", "Is there any indication of a shared upper digestive tract or anatomical obstruction that could complicate feeding and digestion?", "Does the image suggest altered body surface area or shared metabolic regions that might disrupt thermoregulation?", "Can you see signs of shared hepatic or endocrine organs that could affect metabolic homeostasis?", "Is there visual evidence of shared lymphatic structures that might increase susceptibility to infections?", "Do you observe duplicated or fused neural pathways or musculoskeletal structures that could impair coordination of motor activities?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Does the image show a structure that is part of the axial skeleton?"], "contexual_behavior": [], "functions": ["Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}}, "foramina magna": {"yes_questions": {"contexual_properties": ["Does the image show an opening at the craniovertebral junction that appears enlarged, as might be seen in achondroplasia or basilar invagination?", "Is there evidence of narrowing at the base of the skull, suggestive of conditions like Chiari malformation or craniosynostosis?", "Can you identify a structure whose shape appears altered due to congenital anomalies, trauma, or bone disease?", "Is there abnormal bone growth near the cranial base, as might occur in osteopetrosis or Paget\u2019s disease?", "Does the image reveal irregular margins at the cranial opening, possibly due to chronic pressure, bone erosion, or neoplastic invasion?", "Is there a visible mass compressing the cranial opening, such as a meningioma or herniated brain tissue?", "Can you see an enlarged opening at the skull base, which could be associated with megalencephaly or hydrocephalus?", "Does the cranial base appear misshapen, potentially due to developmental disorders, trauma, or prior surgery?", "Is there an obstruction at the cranial opening caused by a lesion, cyst, or downward herniation of cerebellar tissue?", "Can you observe thinning of the bone surrounding the cranial opening, as might be seen in metabolic bone disease or osteoporosis?", "Is there evidence of bony spurs or outgrowths at the base of the skull, suggestive of diffuse idiopathic skeletal hyperostosis or degenerative changes?", "Does the image show signs of bone erosion at the cranial opening, possibly due to chronic inflammation, metastatic cancer, or infection?", "Is there a change in the position of the cranial opening relative to the skull base, as seen in basilar invagination or atlantoaxial dislocation?", "Can you identify calcification around the cranial opening, which might result from metabolic disorders, chronic inflammation, or trauma?", "Does the opening at the cranial base appear asymmetric, potentially due to congenital malformation, trauma, or unilateral bone disease?"], "properties": ["Is there an opening located at the base of the skull within the occipital bone?", "Can you identify a structure with an oval or elliptical shape near the skull base?", "Does the image show an aperture with a diameter close to 35 millimeters?", "Is there a feature whose area appears to be within the range of 700 to 900 square millimeters?", "Can you see an opening with a circumference of approximately 100 millimeters?", "Is there a structure with an average height of about 30 millimeters and width of around 27 millimeters?", "Does the image contain an opening oriented in an anteroposterior direction, sloping slightly forward?", "Can you identify a feature formed entirely by the occipital bone?", "Is there evidence of size variation in the opening that could be attributed to differences in age or developmental stage?"], "relational": ["Is there a large opening within the occipital bone visible in the image?", "Can you identify a structure located in the posterior cranial fossa of the skull?", "Does the image show an area where the medulla oblongata or spinal cord passes through?", "Is there a region where vertebral arteries or spinal accessory nerves might traverse?", "Can you see anatomical features adjacent to a large cranial opening, such as occipital condyles or the clivus?", "Is there a structure near the jugular tubercles in the posterior part of the skull?", "Does the image display a connection between the cranial cavity and the cervical spinal canal, starting with the atlas (C1 vertebra)?", "Is there evidence of ligaments such as the tectorial membrane or alar ligaments attaching near a major cranial opening?", "Can you identify an area where the anterior or posterior spinal arteries enter or exit the skull?", "Is there a visible relationship between the occipital bone and the passage of lower cranial nerves (IX\u2013XI)?"], "contexual_behavior": ["Does the image show evidence of an opening at the base of the skull where cerebrospinal fluid flow might be obstructed during increased intracranial pressure?", "Is there a region where downward displacement of brain tissue, such as the cerebellar tonsils, could impair neural transmission?", "Can you identify an area that might restrict the normal passage of the brainstem in the presence of congenital malformations like Chiari malformation or basilar invagination?", "Does the image reveal signs of vascular structures, such as vertebral arteries or veins, being compressed by swelling, hemorrhage, or bone displacement after trauma?", "Is there visual evidence of compromised protection for neural structures due to downward herniation of cerebellar tissue, as seen in Chiari malformation?", "Can you see abnormal displacement of cerebellar tissue through an opening at the base of the skull, possibly due to raised intracranial pressure?", "Does the image suggest changes in craniospinal communication following surgical procedures like decompressive craniectomy or decompression at the cranial base?", "Is there an indication of cerebrospinal fluid drainage being obstructed by herniated tissue or congenital narrowing, as might occur in hydrocephalus?", "Can you detect signs of bone erosion or weakening at the cranial base that could be caused by metastatic disease?", "Is there evidence of downward displacement of the brainstem, potentially resulting from acute brain swelling and increased intracranial pressure?"], "functions": ["Does the image show a large opening at the base of the skull that serves as a passageway for the medulla oblongata?", "Can you identify a structure that provides direct anatomical continuity between the brainstem and the spinal cord?", "Is there an opening visible that allows neural tissue and meninges to pass from the cranial cavity into the vertebral canal?", "Does the image contain a feature that permits the transition of motor and sensory neural tracts between the brain and spinal cord?", "Can you see an opening through which vertebral arteries and spinal arteries enter the cranial cavity to supply blood to the brain?", "Is there a structure at the cranial base that encases and protects the lower brainstem and upper spinal cord within the skull?", "Does the image show a region that enables the flow of cerebrospinal fluid between the cranial and spinal subarachnoid spaces?", "Can you identify a feature that contributes to cranial stability by connecting the skull to the vertebral column at the atlanto-occipital joint?", "Is there an opening that could serve as a conduit for pressure equalization between the cranial and spinal compartments, influencing intracranial pressure?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure that seems to have moderate to high stromal cell density?", "Is there a mass present that measures between 5 and 10 centimeters in diameter?", "Does the image show a lesion with minimal or absent cellular atypia?"], "relational": ["Does the image show a structure associated with the reproductive system?", "Is there a mass containing stromal or connective tissue visible?", "Is there a mass located within the pelvic cavity?"], "contexual_behavior": ["Can you see an area where sex steroid production might be diminished due to cellular degeneration or insufficient theca cell function?", "Can you identify a structure whose hormone production may be altered in the presence of other ovarian tumors due to local paracrine signaling?", "Does the image show a feature that might impair ovarian function during menopause by disrupting hormone balance?"], "functions": ["Is there evidence of a tumor that may cause estrogen overproduction?", "Does the image contain a mass that could disrupt normal ovarian function or alter the ovarian environment?", "Does the image suggest the presence of a mass that could cause menstrual irregularities or abnormal uterine bleeding?"]}}, "cephalothoracopagus": {"yes_questions": {"contexual_properties": ["Does the image show two individuals with noticeable asymmetry in size that could suggest unequal distribution of shared organs or tissues?", "Is there evidence of abnormal skin color at a region where two bodies are joined, possibly indicating compromised blood flow or vascular anomalies?", "Can you observe differences in organ composition or arrangement between the two individuals, suggesting incomplete duplication or fusion of vital organs?", "Is there an increased overall body weight or bulkiness that might be due to accumulation of shared tissues or fluid retention at a junction?", "Does the image reveal abnormal tissue structures or irregularities at the area where the two bodies are fused, possibly resulting from disrupted tissue differentiation?", "Are there visible changes in the size or shape of the head or thorax between the two individuals, indicating disproportionate growth or malformation of cranial or thoracic structures?", "Can you identify altered or abnormal vascular patterns at the site where the two bodies are joined, which might be consistent with vascular malformations?", "Is there localized swelling or puffiness at the fusion site that could be due to fluid accumulation or lymphatic obstruction?", "Does the image show abnormal bone formation, such as fused or malformed bones, at the area where the two bodies are connected?", "Are there visible signs that suggest differences in organ function or metabolic activity between the two individuals, such as asymmetry in measurable features?", "Can you observe any fluid accumulation at the junction of the two bodies, possibly indicating impaired drainage or increased vascular permeability?", "Is there a change in tissue density or texture at the area of union, which could be due to abnormal tissue composition or fibrosis?", "Does the fusion area display abnormal pigmentation or localized skin changes that might be related to vascular or developmental anomalies?", "Are there differences in limb size between the two individuals, suggesting disproportionate limb growth due to unequal nutrient or blood supply?", "Can you detect abnormal or unequal growth rates in either individual, potentially resulting from differential organ sharing or metabolic imbalance?"], "properties": ["Does the image show an individual whose overall size is similar to that of a term newborn?", "Can you identify a body with two heads that appear fused together and share a single upper torso?", "Is there evidence of two faces or crania that are joined at both the head and chest regions?", "Does the image display a configuration where the upper organs, such as the heart or lungs, might be shared between two heads?", "Are there four limbs visible, with two upper and two lower extremities, or any signs of limb duplication?", "Do the heads appear side by side or partially merged at the cranial region?", "Is there a single, broad chest cavity that could contain shared thoracic organs?", "Can you observe features suggesting a single heart, or possibly two hearts, within a shared thorax?", "Does the vertebral column appear partially fused in the neck and chest areas, with possible duplication below the chest?", "Are the head circumferences of each head within the range typical for newborns, approximately 32 to 38 centimeters?", "Is the skin color consistent with that of a non-conjoined newborn of the same ethnicity?", "Do the facial features appear duplicated, partially merged, or show midline fusion or asymmetry?", "Is the overall length of the body between 45 and 55 centimeters, similar to a term neonate?", "Can you see evidence of fused skulls with possible duplication of brain or facial structures?", "Are there signs that the lower organs might be duplicated while the upper organs are shared?"], "relational": ["Does the image show two individuals with their head and upper chest regions fused together?", "Can you identify a case where the skulls and cervical spines of two bodies are connected?", "Is there evidence of a shared cranial vault or merged facial bones between two individuals?", "Does the image display a fusion that extends from the top of the skull to the upper abdomen?", "Can you see two bodies with a contiguous cranial and thoracic region?", "Is there a visible merging of the neck and upper thorax between two individuals?", "Does the image suggest the presence of shared organ systems such as the upper respiratory, cardiovascular, or digestive systems between two bodies?", "Can you identify a structure where the brain, heart, or liver appears to be joined between two individuals?", "Is there a case of shared or interconnected circulatory systems, such as a common heart or major vessels, visible in the image?", "Does the image show merged cranial or thoracic cavities between two individuals?", "Can you see evidence of connected cerebral hemispheres, brainstem, or cranial nerves between two bodies?", "Is there a fusion involving the nasal cavities, pharynx, larynx, trachea, or upper lungs of two individuals?", "Does the image display a joining of the upper gastrointestinal tract, such as the esophagus, between two bodies?", "Can you observe anatomical boundaries of fusion that include both the cranial and thoracic regions?", "Is there a visible connection of the upper thoracic skeleton, including the thoracic cage, between two individuals?"], "contexual_behavior": ["Does the image show individuals with shared thoracic structures that could limit lung capacity or airway patency?", "Is there evidence of a shared cardiovascular system that might struggle to compensate during physiological stress?", "Can you identify features suggesting incomplete or mismatched neural pathways between conjoined individuals?", "Does the image depict overlapping hepatic or pancreatic tissues that could compromise metabolic processing?", "Is there a visible fusion or abnormality in the gastrointestinal tracts that might affect feeding coordination?", "Can you see anatomical features indicating disrupted thermoregulation due to shared or abnormal hypothalamic control?", "Is there evidence of merged or cross-reactive immune systems that could alter immune responses compared to single individuals?", "Does the image suggest shared or underdeveloped renal or hepatic systems that might decrease waste elimination efficiency?", "Can you identify features that could compromise immune cell production or distribution, affecting infection or inflammation responses?", "Is there anatomical evidence of fused or dysregulated glands, such as the thyroid or pituitary, that might impact endocrine function?", "Does the image show shared hearts or vessels that could impair circulation during physical exertion?", "Is there evidence that shared respiratory or circulatory systems might limit oxygen delivery under hypoxic conditions?", "Can you see signs that shared organ systems could make it difficult to maintain homeostasis during illness?", "Is there anatomical indication of incomplete or conflicting neural circuits that might decrease neural control of movement in response to stress?", "Does the image suggest functional limitations of shared organs that could impair growth or development for both individuals?"], "functions": ["Does the image show individuals with evidence of fused organs or complex anatomical connections?", "Can you identify any signs of compromised organ function or physiological complexity in the depicted structures?", "Is there visual evidence of shared organs that might be functioning under abnormal conditions?", "Does the image suggest an increased risk of organ failure due to impaired efficiency of shared anatomical structures?", "Can you observe features indicating shared or fused hearts or blood vessels, potentially leading to abnormal blood flow?", "Is there any indication of hemodynamic instability or vascular fusion in the circulatory system?", "Does the image show shared or malformed airways or lungs that could compromise respiratory processes?", "Can you see signs of reduced respiratory efficiency or potential for respiratory distress?", "Is there visual evidence of fused or duplicated neural structures that might affect coordination or neural control?", "Do the depicted individuals show features that could lead to conflicting neural signals or coordination challenges?", "Can you identify shared livers or endocrine organs that might disrupt metabolic regulation or homeostasis?", "Is there any indication of difficulties in maintaining metabolic balance or signs of endocrine disruption?", "Does the image suggest shared gastrointestinal tracts or vascular systems that could affect nutrient absorption and distribution?", "Can you observe features that might lead to unequal nutrient delivery or risk of malnutrition?", "Is there evidence of shared or malformed excretory organs that could impair waste elimination?", "Does the image suggest a risk of metabolic waste accumulation or renal dysfunction?", "Can you see fused skeletal or muscular systems that might restrict movement or motor control?", "Is there visual evidence of limited mobility or motor impairment due to anatomical fusion?", "Do the depicted individuals show signs of shared lymphatic tissues or atypical immune system features?", "Is there any indication of altered immune responses or exposure to different antigens in the shared anatomy?"]}, "no_questions": {"contexual_properties": ["Does the image reveal any areas that might have lost sensation, as seen in peripheral neuropathy?", "Can you identify a region that appears colder than surrounding areas, possibly due to reduced blood flow?", "Is there visible discoloration that might be associated with vascular disorders or fungal infections?"], "properties": [], "relational": ["Is there a region that includes joints such as the ankle joint or metatarsophalangeal joints?", "Does the image show compartments such as medial, lateral, central, or interosseous compartments within a structure?", "Does the image display a structure connected to muscles like the flexor digitorum brevis or abductor hallucis?"], "contexual_behavior": ["Can you see a structure that could alter its load-bearing function due to increased body weight?", "Does the image show a body part that could have reduced propulsion if muscle strength or tendon function were compromised?", "Is there a visible area that could experience decreased muscle activity during prolonged immobility?"], "functions": ["Can you identify an anatomical feature responsible for distributing body weight through arches during standing or walking?", "Does the image show a part that contributes to stability by offering a broad base of support?", "Is there a feature that helps maintain posture by making micro-adjustments to body alignment?"]}}, "twins": {"yes_questions": {"contexual_properties": ["Does the image show more than one fetus with a noticeable difference in size, particularly in the third trimester?", "Can you identify two fetuses whose birth weights appear lower than expected for their gestational age after the second trimester?", "Is there evidence of slowed growth rate in two fetuses compared to what would be expected for a single fetus at 28 to 32 weeks of gestation?", "Does the image reveal a significant size difference between two fetuses after 28 weeks?", "Can you observe differences in amniotic fluid volume between two fetuses, which might suggest a complication such as transfusion syndrome?", "Is there a placenta that appears larger than what is typical for a single fetus, especially in the third trimester?", "Do the head circumferences of two fetuses appear smaller than the norm for their gestational age after 32 weeks?", "Is there a visible difference in the length of two newborns that could be related to gestational age or chorionicity?", "Can you observe signs that might indicate changes in hemoglobin levels in two fetuses, such as pallor or evidence of anemia?", "Does the image suggest an increased risk of low birth weight in two infants, particularly after 32 weeks of gestation?", "Is there a visible reduction in body fat percentage in two newborns, especially if they appear preterm?", "Can you detect signs of delayed organ development in two infants, particularly in the context of preterm birth or growth restriction?", "Is there a difference in crown-rump length between two fetuses that becomes more pronounced in the second or third trimester?", "Does the image show discordance in fetal weight between two fetuses, especially in the third trimester?", "Can you infer that the gestational age at delivery for two infants is earlier than typical, such as between 34 and 37 weeks?", "Are there visible indications of congenital anomalies in two infants, particularly if they appear monozygotic?", "Do the Apgar scores of two newborns appear to differ, especially in the context of preterm delivery or birth complications?", "Is there evidence that bone mineral content is lower in two infants at birth, particularly if they are preterm?", "Can you observe differences in cord blood composition between two newborns that might suggest transfusion syndrome or discordant growth?", "Does the image suggest that two infants were born preterm, before 37 weeks of gestation?", "Is there a change in the head-to-abdomen circumference ratio in two fetuses that could indicate growth restriction or discordant growth in the third trimester?"], "properties": ["Are there two newborns present whose combined birth weights appear lower than that of a typical singleton?", "Can you identify a pair of infants who seem to have been born slightly before full term, around 36 to 37 weeks of gestation?", "Is there evidence of two neonates with birth lengths in the range of 45 to 47 centimeters?", "Do you observe a pair of newborns with head circumferences between 32 and 34 centimeters?", "Are there two infants whose Apgar scores at 5 minutes might fall within the 7 to 9 range?", "Can you see a pair of siblings with a noticeable but not extreme difference in birth weight, possibly around 10 to 20 percent?", "Is there visual indication of two placentas or a shared placental structure, suggesting dichorionic or monochorionic placentation?", "Do you observe two infants who might share the same blood type, as would be expected in identical siblings?", "Are there two newborns whose growth rate in infancy might be slightly lower than that of a single infant, with potential for catch-up growth?", "Is there evidence of two neonates with hemoglobin levels likely within the 14 to 20 g/dL range?", "Do both infants display a pink or reddish skin color similar to that of singletons at birth?", "Are there two newborns whose body temperatures are approximately 36.5 to 37.5 degrees Celsius?", "Can you identify a pair of infants with heart rates in the normal neonatal range of 120 to 160 beats per minute?", "Are there two newborns with respiratory rates between 30 and 60 breaths per minute?", "Is there any indication that the incidence of congenital anomalies is higher among the pair of infants compared to a single newborn?"], "relational": ["Does the image show more than one fetus within the uterine cavity?", "Can you identify two individuals that may be sharing or occupying separate compartments within the uterus?", "Is there evidence of shared or separate placental structures present in the image?", "Does the image display two umbilical cords connecting to a single or multiple placental masses?", "Can you see fetal membranes such as the amnion or chorion surrounding more than one fetus?", "Is there a visible arrangement suggesting dichorionic or monochorionic placentation?", "Does the image indicate the presence of diamniotic or monoamniotic sacs around the fetuses?", "Are there maternal anatomical features such as the uterus, endometrium, or maternal blood vessels interacting with multiple fetuses?", "Can you observe vascular connections between placental regions, such as arterio-arterial or veno-venous anastomoses?", "Does the image provide visual cues that could help distinguish between genetically identical and genetically distinct siblings based on membrane or placental sharing?", "Is there evidence of the maternal cardiovascular, endocrine, or reproductive systems supporting more than one developing fetus?"], "contexual_behavior": ["Does the image show more than one newborn who might have experienced altered immune interactions during fetal or neonatal life?", "Can you identify two infants who may have shared nutrients differently during the second or third trimester of pregnancy?", "Is there evidence of multiple newborns whose growth rates could have been influenced by maternal health during gestation?", "Does the image suggest the presence of two infants who might be at risk for placental dysfunction, such as in twin-to-twin transfusion syndrome, especially during the second trimester?", "Can you see a pair of newborns whose metabolic activity may have been affected by intrauterine competition in late gestation?", "Is there a visible difference in birth weight between two infants that could be related to maternal stress during the third trimester or at delivery?", "Does the image include infants who might be at increased risk for developmental delays due to being born before 37 weeks of gestation?", "Can you identify two newborns who may have experienced altered hormonal regulation during fetal or early postnatal life?", "Is there evidence of immune tolerance changes between two infants, possibly indicating a monochorionic pregnancy during mid to late gestation?", "Does the image show a pair of infants who could be at risk for organ function impairment due to shared circulation, such as in monochorionic gestation or twin-to-twin transfusion syndrome?", "Are there two newborns who might have experienced changes in oxygen delivery during a complicated or prolonged labor?", "Can you see infants in a neonatal intensive care setting who may have increased susceptibility to infections, particularly if they are preterm?", "Does the image suggest a pair of infants whose rate of growth catch-up might differ from that of singletons during infancy or early childhood?", "Is there evidence of two newborns whose neurological development could have been affected by perinatal hypoxia during birth or the immediate neonatal period?", "Can you identify infants whose metabolic adaptation might differ depending on whether they are being breastfed or formula fed during the neonatal or early infancy stages?"], "functions": ["Does the image show more than one fetus sharing a uterine environment?", "Can you identify two individuals who appear to have lower birth weight compared to typical singletons?", "Is there evidence of preterm birth or perinatal complications affecting more than one newborn in the image?", "Do you observe physical contact or close proximity between two developing fetuses?", "Is there a shared amniotic space or indications of shared placental circulation visible?", "Can you see signs of division of a single zygote, such as identical-appearing fetuses?", "Is there visual evidence suggesting competition for uterine resources, such as discordant growth between two fetuses?", "Do you notice features consistent with growth restriction or differences in size between two co-developing individuals?", "Is there any indication of unequal blood flow or complications that could suggest twin-to-twin transfusion syndrome?", "Can you identify vascular connections or placental features that might indicate blood flow imbalance between two fetuses?", "Is there evidence of immune modulation, such as shared antigens or microchimerism, between two developing individuals?", "Do you observe placental pathophysiology, such as abnormal vascular anastomoses, that could affect more than one fetus?", "Are there signs of adverse birth outcomes, such as preterm delivery or the need for neonatal intensive care, involving two newborns?", "Can you distinguish phenotypic variation or differences in traits that might suggest genetic or epigenetic influences between two individuals?", "Is there evidence of hormonal signaling or behavioral interaction between two closely positioned newborns?"]}, "no_questions": {"contexual_properties": ["Does the image display bony overgrowth at the cranial base that might be linked to mucopolysaccharidosis or sclerotic bone disease?", "Is there evidence of structural deformity in a skull base opening that could result from genetic mutation, trauma, or chronic disease?", "Can you observe increased bone density in the region of a cranial foramen, which could be associated with metabolic bone disorders or sclerosing dysplasias?"], "properties": ["Is there a feature where the flow of cerebrospinal fluid through an opening appears diminished, potentially less than 5 ml/min?", "Is there an area where the cross-sectional opening is reduced to less than 200 mm\u00b2?", "Is there a region at the base of the skull where the opening appears narrowed by approximately 30% to 60% compared to typical anatomy?"], "relational": ["Is there evidence of compression or impingement on nerves such as the spinal accessory nerve or upper cervical spinal nerves near the craniovertebral junction?", "Does the image show any abnormal narrowing at the craniovertebral junction or skull base?", "Does the image reveal any abnormalities involving ligaments like the tectorial membrane or alar ligaments in the region where the skull meets the spine?"], "contexual_behavior": [], "functions": ["Does the image suggest possible disruption of respiratory or cardiovascular regulation due to brainstem involvement?", "Can you see any abnormality that might impinge on the medulla oblongata or upper cervical spinal cord?", "Does the image show narrowing that could impede the passage of cranial nerves responsible for swallowing, vocalization, or shoulder movement?"]}}, "single fused calvarium": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a cranial structure where the bones appear to be fused into a single unit?", "Is there evidence of a skull without visible sutures separating individual bones?", "Can you identify a cranial vault that lacks the typical segmentation seen in normal skull anatomy?"], "relational": ["Does the image show a structure that is part of the skeletal system and forms the superior and lateral boundaries of the cranial cavity?", "Can you identify a continuous bony shell enclosing the brain and cranial blood vessels?", "Is there an object that appears to be formed by the fusion of bones such as the frontal, parietal, occipital, temporal, and sphenoid bones?", "Does the image contain a structure that includes the cranial vault and calvarial roof?", "Can you see evidence of tissues such as periosteum, dura mater, or scalp attached to a bony surface?", "Is there a structure that connects to the facial skeleton through features like the cranial base or zygomatic arches?", "Can you identify membranes such as dura mater, arachnoid mater, or pia mater associated with a bony enclosure?", "Does the image show the absence of normal cranial sutures such as the coronal, sagittal, or lambdoid sutures?", "Is there a visible bony structure characterized by the absence of sutures and the presence of a continuous shell?"], "contexual_behavior": ["Does the image show a structure where multiple cranial bones appear to be joined together as a single unit?", "Can you identify a region of the skull that lacks visible sutures between its major components?", "Is there evidence of fusion among the bones that typically form the cranial vault?"], "functions": ["Does the image show a rigid, continuous bony shell that could serve as a barrier against trauma to the brain?", "Is there a structure present that provides encasement and protection for the brain?", "Can you identify a feature that forms the cranial vault and maintains its shape?", "Does the image contain a unified bony dome that lacks visible sutures, suggesting enhanced skull stability?", "Is there evidence of a structure that could provide attachment sites for the meninges or scalp?", "Can you see a bony surface broad enough to support the attachment of head or neck muscles?", "Is there a structure that appears to shield sensory organs such as the eyes or ears by forming part of the cranial walls or roof?", "Does the image show a compartment that could help regulate intracranial pressure by resisting deformation?", "Is there a structure that encloses cranial blood vessels within bony grooves or foramina, offering vascular protection?", "Can you identify a feature that plays a role in shaping and enclosing the cranial cavity during development?"]}, "no_questions": {"contexual_properties": ["Does the image show any localized fluid accumulation that could correspond to a cyst, abscess, or edema?", "Can you identify regions where tissue appears to be missing, which could result from necrosis, infarction, or surgical removal?", "Is there evidence of abnormal mass formation, such as a tumor, cyst, or granuloma?"], "properties": ["Does the image show a structure with a resolution typical of light microscopy, around 0.2 micrometers?", "Can you see an area that might span from a few square millimeters to several square centimeters?", "Can you identify an area where the refractive index might fall between 1.47 and 1.53, depending on the mounting medium?"], "relational": ["Does the image reveal separation between left and right structures, such as the two cerebral hemispheres or nasal cavities?", "Can you determine if the body is divided into left and right portions rather than front and back or top and bottom?", "Are anatomical landmarks like the midline, nasal septum, or vertebral bodies visible in a longitudinal orientation?"], "contexual_behavior": ["Does the image provide a clear view of spinal cord deformation or narrowing that would be useful for assessing cord compression?", "Can you see features such as synovial thickening or joint effusion that might affect joint movement in the context of inflammatory arthritis?", "Does the image reveal reduced or absent vascular flow that might suggest vessel occlusion or interrupted blood flow?"], "functions": ["Can you identify how organs and tissues are arranged from front to back in this image?", "Is it possible to observe physiological processes such as swallowing or breathing based on the orientation shown?", "Can you see clear views of midline structures that would be useful for functional visualization in imaging studies?"]}}}
[ { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "beckwith-wiedemann syndrome", "extracted_concepts": [ "beckwith-wiedemann syndrome" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "beckwith-wiedemann syndrome" ], "question": "is beckwith-wiedemann syndrome present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "beckwith-wiedemann syndrome", "extracted_concepts": [ "beckwith-wiedemann syndrome" ], "question": "what is present?" } ]	["beckwith-wiedemann syndrome", "face"]	{"beckwith-wiedemann syndrome": {"yes_questions": {"contexual_properties": ["Is there evidence of organ enlargement that could have developed before or shortly after birth?", "Does the image show signs of increased birth weight or fetal overgrowth?", "Can you identify asymmetric limb growth that might be present from birth or early childhood?", "Is there an enlarged tongue visible, particularly in a newborn or infant?", "Does the image reveal any abdominal wall defects, such as omphalocele or umbilical hernia, that are apparent at birth?", "Are there indications of low blood glucose, especially in a neonate?", "Can you see signs of kidney enlargement that may be present prenatally or in early childhood?", "Is there any facial appearance suggestive of midface hypoplasia or prominent eyes in an infant?", "Does the image suggest a predisposition to embryonal tumors, especially in a child?", "Are there visible changes in organ structure, such as altered tissue architecture or cellular overgrowth, in early development?", "Can you detect abnormal ear creases or pits, such as posterior helical pits, present at birth?", "Is there evidence of accelerated somatic growth, particularly in the prenatal or early postnatal period?", "Does the image suggest increased amniotic fluid volume, which might be detected during pregnancy?", "Can you see signs of an enlarged placenta during pregnancy?", "Are there indications of abnormal tissue composition, such as increased mesenchymal tissue or organ hyperplasia, in early life?"], "properties": ["Does the image show an individual with features such as excessive body size or rapid linear growth during infancy?", "Is there evidence of a tongue that appears unusually large compared to the oral cavity?", "Can you identify any organs that appear enlarged relative to typical pediatric anatomy?", "Is there asymmetry in limb or body size suggestive of hemihyperplasia?", "Does the abdominal region display signs of wall defects, such as an omphalocele or umbilical hernia?", "Is the birth weight or overall size of the infant above the 90th percentile for age and sex?", "Does the head circumference appear disproportionately large, possibly exceeding the 90th percentile?", "Are there facial features such as midface hypoplasia, prominent eyes, or visible ear creases or pits?", "Can you observe any signs of nephromegaly, such as visibly enlarged kidneys?", "Is there evidence of tall stature in the child, with height above the 90th percentile for age?", "Does the image suggest the presence of tumors such as Wilms tumor or hepatoblastoma?", "Are there visual indications of neonatal hypoglycemia, such as lethargy or abnormal feeding behavior?", "Can you see any laboratory findings or annotations indicating elevated insulin levels or abnormal methylation at the 11p15 region?", "Is there an umbilical hernia or omphalocele present in the abdominal area?", "Are there any visible signs of organomegaly affecting multiple organs?", "Does the image show a child with features that typically present at birth or in the neonatal period?", "Are there ear creases or pits visible on the external ear in the image?", "Is there evidence of both macroglossia and organomegaly in the same individual?"], "relational": ["Does the image show evidence of overgrowth in soft tissue, muscle, or connective tissue?", "Can you identify any asymmetry in the limbs or face suggestive of hemihyperplasia?", "Is there visible enlargement of the tongue or other features consistent with macroglossia?", "Does the image reveal abnormalities in the abdominal wall, such as incomplete closure or omphalocele?", "Are there signs of visceromegaly, such as an enlarged abdomen or prominent abdominal organs?", "Can you see any features indicating enlargement of the kidneys, liver, or limbs?", "Is there evidence of structural changes in the ear, such as creases or pits?", "Does the image suggest increased size or abnormal appearance of the pancreas or adrenal glands?", "Are there visual cues of altered tissue growth regulation in the musculoskeletal or lymphatic systems?", "Can you observe any changes in embryonic-derived structures, such as the abdominal wall or somatic tissues?", "Is there any indication of tumor risk in abdominal organs like the kidneys or liver?", "Does the image show involvement of multiple organ systems, such as endocrine, digestive, or genitourinary systems?", "Are there visible changes in the face, abdomen, or limbs that could be associated with a congenital overgrowth syndrome?"], "contexual_behavior": ["Does the image show evidence of abnormal growth regulation during fetal development or early childhood, possibly due to disruptions in imprinted gene expression?", "Is there a visible indication of increased risk for embryonal tumors, such as Wilms tumor or hepatoblastoma, particularly in a child?", "Can you identify features suggestive of metabolic dysfunction in infancy, such as signs of hypoglycemia or pancreatic islet cell hyperplasia?", "Does the image display signs of persistent hypoglycemia or disrupted glucose homeostasis during the neonatal period or early infancy?", "Is there evidence of organ overgrowth affecting the liver, kidneys, or tongue during prenatal development or early childhood?", "Can you see indications of abnormal hormone secretion in infancy or childhood, such as increased insulin production or pancreatic beta-cell hyperplasia?", "Does the image suggest postprandial hypoglycemia or impaired blood sugar regulation after feeding in a newborn?", "Is there any sign of susceptibility to hypoglycemia during fasting in a newborn or infant, possibly due to dysregulated insulin secretion?", "Can you identify features that might indicate metabolic instability or increased risk of hypoglycemia in response to surgical stress at any age?", "Does the image show structural anomalies such as nephromegaly or adrenal cytomegaly, suggesting altered kidney or adrenal gland function during childhood?", "Is there any evidence of secondary effects on the immune system during early development, even if immune dysfunction is not the primary feature?", "Can you observe signs of altered growth factor response, such as changes in IGF2 expression, affecting development?", "Does the image reveal abnormal placental function during pregnancy, such as placentomegaly or related complications?", "Is there any indication of impaired wound healing or tissue regeneration in a child, possibly due to altered cellular proliferation or growth factor signaling?", "Can you see signs of increased metabolic rate or anabolic activity during childhood, potentially associated with organ overgrowth?", "Does the image suggest impaired regulation of cell proliferation during embryonic or early postnatal development, possibly due to loss of imprinting at growth-regulating loci?", "Is there evidence of altered defense against oxidative stress during early life, even if this is not a primary clinical feature?", "Can you identify features of hepatomegaly or metabolic disturbances affecting liver function during neonatal development?", "Does the image show generalized or organ-specific overgrowth in infancy or childhood, indicating increased anabolic activity?", "Is there any indication of reduced effectiveness of normal growth suppression mechanisms throughout development, possibly due to epigenetic alterations affecting growth-regulatory genes?"], "functions": ["Does the image show evidence of generalized overgrowth or organ enlargement?", "Can you identify any signs of abnormal growth regulation, such as excessive prenatal or postnatal size?", "Is there visual evidence of metabolic imbalance, such as features suggestive of neonatal hypoglycemia?", "Does the image display enlargement of specific organs, such as the tongue, kidneys, or liver?", "Can you see any indications of abnormal insulin secretion or altered growth factor signaling?", "Is there evidence of increased cellular proliferation or abnormal tissue growth?", "Does the image suggest a predisposition to embryonal tumors, such as Wilms tumor or hepatoblastoma?", "Are there features consistent with glucose dysregulation, particularly in a neonatal context?", "Can you observe abnormal growth patterns or asymmetry in organ development?", "Is there visual evidence of altered sensitivity to growth signals, possibly due to changes in growth factor pathways?"]}, "no_questions": {"contexual_properties": ["Does the image show a tubular structure adjacent to the left side of the uterus?", "Is there a visible structure to the left of the uterus that could be responsible for hormone production?", "Does the image contain a pair of connected structures to the left of the uterus, one appearing as a tube and the other as a rounded organ?"], "properties": ["Can you identify an organ on the left of the uterus that is typically paired and involved in gamete production?", "Can you see a tube and a small organ located to the left of the uterus?", "Is there a structure to the left of the uterus that appears to connect a tube-like formation with a small, oval organ?"], "relational": ["Can you identify structures that might be innervated by the ovarian plexus or pelvic splanchnic nerves?", "Does the image show a passage or duct, such as a lumen, leading from a tubular structure into the peritoneal cavity or ovarian hilum on the left side?", "Can you see a structure that could be supplied by the left ovarian artery or left uterine artery?"], "contexual_behavior": ["Can you see a pair of structures to the left of the uterus that are typically associated with ovulation and gamete transport?", "Does the image show an organ on the left side of the uterus that may be involved in oocyte production or transport?", "Can you identify a tubular structure adjacent to the uterus on the left side?"], "functions": ["Is there a region that facilitates the transport of gametes from the ovary toward the uterus on the left side?", "Does the image show a structure responsible for producing oocytes on the left side of the uterus?", "Does the image show a tube that could help clear debris from the reproductive tract through mucociliary transport on the left?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": ["Can you see a mass with cystic regions, possibly resulting from central necrosis or degeneration?", "Does the image suggest changes in the molecular composition of a mass, potentially due to progression, therapy, or clonal evolution?", "Is there a mass with rare calcifications, possibly associated with prior therapy or necrotic changes?"], "properties": ["Is the tumor consistent with a basal-like molecular subtype based on its appearance or marker expression?", "Does the tissue appear pale or gray-white with visible areas of necrosis?", "Does the tumor appear in a patient who is younger than typical for other breast cancer subtypes, such as around 40 to 50 years old?"], "relational": ["Can you identify epithelial or basal-like tumor cells in the sample?", "Is there evidence of a malignancy involving the axillary lymph nodes?", "Does the image show a carcinoma affecting breast tissue or the mammary gland epithelium?"], "contexual_behavior": [], "functions": ["Does the tumor microenvironment show signs of stromal cell recruitment or increased inflammation?", "Is there a visible indication of angiogenesis, such as increased blood vessel formation around a tumor?", "Is there evidence of alternative growth pathways being utilized by any of the cancerous tissues?"]}}}
[ { "answer": "lateral view of head ear lobe crease web neck other photos in file", "extracted_concepts": [ "whole body", "anterior face", "kidneys", "diastasis recti", "head", "web neck", "lateral view of head", "bilateral pelvic-ureteral strictures", "ear lobe crease" ], "question": "what are anterior face whole body showing diastasis recti and kidneys with bilateral pelvic-ureteral strictures?" }, { "answer": "anterior face", "extracted_concepts": [ "whole body", "anterior face", "kidneys", "diastasis recti", "web neck", "lateral view of head", "bilateral pelvic-ureteral strictures", "ear lobe crease" ], "question": "what are lateral view of head with ear lobe crease and web neck other photos in file whole body showing diastasis recti and kidneys with bilateral pelvic-ureteral strictures?" }, { "answer": "lateral view of head with ear lobe crease and web neck other photos in file are anterior face whole body showing diastasis recti and kidneys with bilateral pelvic-ureteral strictures", "extracted_concepts": [ "kidneys", "diastasis recti", "web neck", "bilateral pelvic-ureteral strictures", "ear lobe crease" ], "question": "what does this image show?" }, { "answer": "beckwith-wiedemann syndrome", "extracted_concepts": [ "beckwith-wiedemann syndrome" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "beckwith-wiedemann syndrome" ], "question": "is beckwith-wiedemann syndrome present?" }, { "answer": "no", "extracted_concepts": [ "angiogram" ], "question": "is angiogram present?" }, { "answer": "lateral view of head ear lobe crease web neck other photos in file", "extracted_concepts": [ "ear lobe", "anterior face", "kidneys", "diastasis recti", "head", "web neck", "lateral view of head", "bilateral pelvic-ureteral strictures", "ear lobe crease" ], "question": "what are anterior face whole body showing diastasis recti and kidneys with bilateral pelvic-ureteral strictures?" }, { "answer": "anterior face", "extracted_concepts": [ "whole body", "anterior face", "kidneys", "diastasis recti", "web neck", "lateral view of head", "bilateral pelvic-ureteral strictures", "ear lobe crease" ], "question": "what are lateral view of head with ear lobe crease and web neck other photos in file whole body showing diastasis recti and kidneys with bilateral pelvic-ureteral strictures?" }, { "answer": "beckwith-wiedemann syndrome", "extracted_concepts": [ "beckwith-wiedemann syndrome" ], "question": "what is present?" } ]	["angiogram", "ear lobe", "anterior face", "whole body", "beckwith-wiedemann syndrome", "kidneys", "diastasis recti", "head", "web neck", "lateral view of head", "bilateral pelvic-ureteral strictures", "ear lobe crease"]	{"angiogram": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image display grayscale regions with high contrast that could represent blood vessels?", "Is there evidence of an imaging modality that produces images with a typical spatial resolution between 0.2 and 0.5 millimeters?", "Can you identify an image that might have a standard size of 1024 by 1024 pixels?", "Does the visualized region appear to cover an area between 10 and 40 centimeters?", "Is there a structure or feature that suggests the use of a contrast agent with a concentration between 300 and 370 mg iodine per mL?", "Can you infer the presence of a procedure where the average duration is approximately 30 to 60 minutes?", "Does the image suggest a radiation-based technique delivering a dose between 5 and 30 millisieverts?", "Is there any indication that the image was acquired at a frame rate between 15 and 30 frames per second?", "Can you see evidence of an image with a pixel depth in the range of 8 to 16 bits per pixel?", "Does the image suggest a 3D acquisition with a slice thickness between 0.5 and 2 millimeters?", "Is there a visual cue indicating that a contrast agent volume of 80 to 120 milliliters may have been administered?", "Can you infer from the image that the contrast agent was injected at a rate of 3 to 6 milliliters per second?", "Does the field of view in the image appear to be within the range of 15 to 40 centimeters?", "Is there evidence that the image acquisition for a series lasted between 5 and 20 seconds?", "Can you assess whether the image quality corresponds to a signal-to-noise ratio between 20 and 40?"], "relational": ["Does the image display structures such as arteries or veins?", "Can you identify blood vessels like coronary, cerebral, or peripheral arteries?", "Is there evidence of anatomical features belonging to the cardiovascular, nervous, or renal systems?", "Does the image include regions such as the heart, brain, limbs, or abdomen?", "Can you see commonly involved vessels such as the femoral artery, radial artery, or jugular vein?", "Is there a depiction of vascular anatomy, blood flow, or vessel patency?", "Are anatomical landmarks like the inguinal ligament, brachial artery, or carotid bifurcation visible?", "Does the image highlight blood vessels, vascular lumen, or branch points?", "Can you observe tissues such as connective tissue, muscle, or fat surrounding blood vessels?", "Is there a visible entry point such as the femoral, radial, or brachial artery?"], "contexual_behavior": [], "functions": ["Does the image provide detailed visualization of blood vessels to assist in diagnosis or treatment planning?", "Can you identify the use of contrast agents to reveal the patency and flow within vessels?", "Is there evidence of imaging that highlights areas of vascular blockage, such as stenosis or occlusion?", "Does the image allow for real-time observation of blood flow dynamics through the vascular system?", "Can you see anatomical maps that could guide catheter placement or other vascular interventions?", "Is there visual information that could assist in detecting circulatory abnormalities like aneurysms, malformations, or thrombosis?", "Does the image support evaluation of arterial health, such as assessing vessel integrity or detecting arterial narrowing?", "Can you compare vessel images to monitor the effectiveness of a vascular treatment or intervention?", "Is there evidence of abnormal vessel morphology, such as irregular shapes, leaks, or unusual branching patterns?", "Does the image provide information about the distribution of blood flow to specific tissues or organs, supporting perfusion assessment?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the nuclear-to-cytoplasmic ratio in these cells appear low to moderate?", "Can you see tightly cohesive clusters of cells with minimal intervening stroma?", "Can you identify a rounded or ovoid cluster of glands?"], "relational": ["Can you see anatomical features adjacent to ducts, blood vessels, or nerves?", "Does the image include a region that could be located in the pelvis, oral cavity, or abdomen?", "Can you identify a structure embedded within or supported by stroma or extracellular matrix?"], "contexual_behavior": ["Can you identify a group of glands that could reduce hormone production in the presence of chronic inflammation or signs of atrophy?", "Does the image show a cluster of structures that might increase secretory activity during periods of hormonal signaling or heightened functional demand?", "Does the image display glandular nests with signs of immune cell infiltration or inflammation that could impair their function?"], "functions": ["Do any regions in the image suggest adaptive changes in secretory activity or cellular proliferation in response to local stimuli?", "Is there evidence of structures that might regulate the composition of local fluids or support balanced cellular turnover?", "Can you see concentrated sites that could be involved in the biosynthesis and release of hormones or enzymes?"]}}, "ear lobe": {"yes_questions": {"contexual_properties": ["Is there a visible structure that appears swollen, possibly due to infection, trauma, or an allergic reaction?", "Can you identify an area that shows color changes such as bruising, cyanosis, or signs of inflammation?", "Does the image show a part that is red, suggesting increased blood flow from irritation or infection?", "Is there a region that looks thickened, which might indicate chronic irritation or keloid formation?", "Can you see a structure that appears thinner, possibly as a result of aging or repeated trauma?", "Is there any evidence of nodules that could represent cysts, keloids, or benign tumors?", "Does the image show discoloration that might be due to hematoma, pigmentation disorder, or vascular compromise?", "Can you identify an area that seems less elastic, perhaps due to aging or sun exposure?", "Is there a region that appears hardened, possibly from scar tissue or chronic inflammation?", "Do you observe any creases that could be associated with aging or cardiovascular disease?", "Is there visible fluid accumulation suggesting edema or an allergic reaction?", "Does any part look tender or inflamed, as indicated by swelling or redness?", "Can you see a region that appears shrunken, possibly from tissue loss or scarring?", "Is there an area that seems enlarged, which could be due to edema, inflammation, or keloid formation?", "Are there any cyst-like structures that might result from blocked sebaceous glands?", "Does the image show signs such as redness, swelling, warmth, or discharge that could indicate infection?", "Is there a region that appears pale, possibly due to poor circulation or anemia?", "Can you identify any scar tissue that may have formed after injury or repeated procedures?", "Is there an area with ulceration, possibly resulting from trauma or skin disease?", "Do you observe any changes in texture that might be related to scarring or chronic dermatological conditions?"], "properties": ["Is there a structure present that measures approximately 1 to 2 centimeters in both length and width?", "Can you identify an area with a thickness of about 4 to 8 millimeters?", "Does the image show a feature that is either attached or free-hanging, and appears rounded or oval in shape?", "Is there a region with a color ranging from light pink to brown, depending on skin tone?", "Can you see a part that appears soft and pliable to the touch?", "Is there a visible structure that likely weighs less than 1 gram?", "Does the image include tissue composed of skin, subcutaneous fat, and connective tissue, but with little or no cartilage?", "Can you identify an area with a relatively high fat content compared to surrounding regions?", "Is there a structure with moderate blood supply, possibly from branches of the posterior auricular or superficial temporal arteries?", "Does the image show a region that could stretch and return to its original shape easily, indicating high elasticity?", "Can you see a part of the image that likely contains about 60 to 70 percent water by weight, similar to other skin areas?", "Is there a structure where collagen is present at moderate levels, primarily within the dermis and connective tissue?", "Does the image show a region where melanin concentration might vary depending on the individual's skin type?", "Can you identify an area with moderate nerve density, supporting tactile sensation and pain perception?", "Is there a structure whose temperature would likely match peripheral skin temperature, around 32 to 34 degrees Celsius?", "Does the image show a region with minimal or absent cartilage, distinguishing it from other parts of the external ear?", "Can you see a structure with low tissue density due to high fat and low cartilage content?", "Is there a region with moderate vascularization and a well-developed capillary network?", "Does the image include an area where the skin pH is likely slightly acidic, between 4.5 and 5.5?", "Can you identify a structure composed of cell types such as keratinocytes, fibroblasts, adipocytes, melanocytes, and endothelial cells?"], "relational": ["Does the image show a structure that is part of the external ear?", "Can you identify a fleshy region forming the lower portion of the external ear?", "Is there a soft tissue area adjacent to the cheek or jawline?", "Does the image contain a region composed mainly of adipose and connective tissue rather than cartilage?", "Can you see a structure that connects to the face at the auriculofacial junction?", "Is there a visible area whose blood supply could come from branches of the posterior auricular or superficial temporal arteries?", "Does the image show a region that might be innervated by the great auricular or auriculotemporal nerves?", "Can you identify an area whose lymphatic drainage could be directed toward the superficial parotid or mastoid lymph nodes?", "Is there a part of the external ear where the skin includes layers such as the epidermis, dermis, and subcutaneous tissue?", "Does the image show a soft, non-cartilaginous structure at the lower end of the external ear?"], "contexual_behavior": ["Is there a structure in the image that might show reduced blood flow when exposed to cold temperatures?", "Can you identify an area that could exhibit diminished tactile sensation if peripheral nerves are damaged?", "Does the image include a part that would increase blood flow for heat dissipation in high temperatures?", "Is there a region that might fail to heal properly after injury or piercing due to infection or poor vascular supply?", "Can you see a structure where wound healing could be delayed in diabetic conditions?", "Is there an area that may be more susceptible to infection after trauma because of disrupted skin barriers?", "Does the image show a part that could demonstrate altered sensation in cases of peripheral neuropathy?", "Can you identify a region that might display decreased elasticity as a result of aging?", "Is there a structure that could have a reduced vascular response in the presence of circulatory disorders?", "Does the image include an area that may be more prone to bruising in bleeding disorders due to fragile capillaries?"], "functions": ["Does the image show a soft tissue structure that provides support for external ornaments or devices?", "Can you identify an area that appears flexible and suitable for the attachment of earrings?", "Is there a region that could serve as a site for ornamentation on the external ear?", "Does the image include a part of the ear that is highly vascularized but does not actively regulate temperature?", "Can you see a structure that might allow for passive heat loss due to its blood supply?", "Is there a visible area that could detect touch or pressure through cutaneous receptors?", "Does the image show a region with a rich capillary network contributing to local blood flow in the external ear?", "Can you identify a part of the ear that might cushion and absorb minor impacts to protect the external ear?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a bone present with a vertebral foramen diameter of about 2.5 cm?", "Is there a ring-shaped, oval bone structure visible in the image?", "Can you identify a bone that lacks a vertebral body?"], "relational": ["Can you identify attachment sites for muscles like the rectus capitis anterior, rectus capitis lateralis, or obliquus capitis superior on a cervical vertebra?", "Does the image contain a joint that enables head rotation, such as a pivot joint between two cervical vertebrae?", "Can you identify a vertebra that articulates with both the occipital bone and another cervical vertebra?"], "contexual_behavior": ["Does the image show diminished ability to absorb mechanical stress in the upper cervical vertebrae, possibly due to fracture or bone loss?", "Can you see excessive movement or instability in the upper cervical region, possibly due to torn or absent ligaments?", "Can you see changes in head tilt facilitation, possibly related to ligamentous laxity from connective tissue disorders or trauma?"], "functions": ["Is there an object that, together with another vertebra, enables rotation of the head through a specialized joint?", "Can you identify an anatomical feature that helps maintain posture by supporting the alignment of the head on the cervical spine?", "Can you see a structure that articulates with the occipital condyles to enable nodding motions?"]}}, "anterior face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region with an oval or slightly rounded contour?", "Can you identify an area whose width appears to be between 12 and 16 centimeters in adults?", "Is there a region with a height that could be approximately 18 to 22 centimeters in adults?", "Does the image display skin tones ranging from light to dark, reflecting individual pigmentation?", "Can you see an area where the skin appears smooth and supple?", "Is there a visible region where the skin seems to be about 1.5 to 2 millimeters thick?", "Are anatomical landmarks such as the forehead, eyes, nose, cheeks, lips, and chin present in the image?", "Does the depicted area contain layers or tissues such as skin, fat, muscle, nerves, blood vessels, and bone?", "Can you observe fat distribution localized in the cheeks, around the eyes, or under the chin?", "Is there evidence of relatively low muscle mass, with facial muscles comprising a small proportion of the tissue?", "Does the image show sparse hair density, with possible increased density in the beard or mustache area in males?", "Can you infer that the tissue water content is likely between 60 and 70 percent by weight?", "Is there an area where the surface temperature could be around 33 to 35 degrees Celsius?", "Does the skin surface appear consistent with a pH range of 4.5 to 5.5?", "Can you identify a region where the underlying bone density might be about 1.2 to 1.5 grams per cubic centimeter?"], "relational": ["Does the image show a region located in the cephalic part of the body?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oris or masseter in the depicted area?", "Does the region appear to receive innervation from cranial nerves such as the facial or trigeminal nerve?", "Are there visible blood vessels that could correspond to the facial artery or superficial temporal artery?", "Can you see sensory organs such as the eyes, nose, or mouth in the image?", "Is there a region adjacent to the scalp, neck, or lateral face present?", "Does the area appear to be covered by layers such as the epidermis or dermis?", "Are there lymphatic structures like submandibular or parotid lymph nodes visible?", "Can you identify spaces such as the oral cavity, nasal cavity, or orbital cavities in the image?"], "contexual_behavior": ["Does the image show a region where sensory perception might be reduced following injury to the trigeminal nerve?", "Can you identify an area that would increase sweat production in response to heat due to sympathetic nervous system activation?", "Is there a structure whose ability to express emotions could be diminished in neurological disorders such as Bell's palsy or Parkinson's disease?", "Does the image include a region that could exhibit impaired muscle movement after a stroke affecting facial nerve pathways?", "Can you see an area that might display increased blood flow during blushing or inflammation due to vasodilation?", "Is there a surface that could show decreased barrier function in dermatological diseases like eczema or psoriasis?", "Does the image contain a region where sensation might be altered during an allergic reaction due to histamine release?", "Can you identify an area that would have reduced mobility in cases of facial paralysis or nerve dysfunction?", "Is there a region that could show increased oil secretion during adolescence or hormonal changes due to sebaceous gland activity?", "Does the image show an area that might lose its ability to regulate temperature in cases of autonomic dysfunction?", "Can you see a region that could experience impaired wound healing in diabetes due to microvascular complications?", "Is there an area that might display increased sensitivity and neuropathic pain in trigeminal neuralgia?", "Does the image include a region where defense against pathogens could be reduced in immunodeficiency states, increasing infection susceptibility?", "Can you identify a region where muscular activity changes during speech or mastication due to coordinated muscle contractions?", "Is there an area that could show reduced tactile discrimination in aging due to loss of mechanoreceptors and nerve degeneration?"], "functions": ["Does the image show a region involved in sensory reception such as vision, olfaction, or touch?", "Can you identify an area that enables facial expression and mimicry through the movement of soft tissues?", "Is there a structure that produces visual cues for nonverbal communication or assists in speech articulation?", "Does the image include features that protect underlying structures like the eyes, nasal cavity, or oral cavity from injury or environmental exposure?", "Can you see anatomical elements that participate in breathing or olfactory detection through airflow and odor sensing?", "Is there evidence of coordinated movements for chewing or speech production involving the jaw, lips, or cheeks?", "Does the image display a surface that could aid in heat dissipation or show signs of vasodilation for temperature regulation?", "Can you observe intact skin or mucous membranes that serve as a barrier against pathogens and contribute to immune defense?", "Is there a region that facilitates social interaction by conveying emotions or intentions through expressions or eye contact?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image reveal a lesion situated in the thoracic region, particularly within the right lower lobe of the lung?", "Does the image show a lesion located within the respiratory system, specifically in the lungs?", "Is there a mass adjacent to anatomical structures such as the bronchi, pulmonary arteries, or pleura?"], "contexual_behavior": [], "functions": ["Is there a structure that might be promoting its own survival by adapting to low oxygen conditions?", "Is there a structure that could be secreting growth factors to modify its microenvironment?", "Does the image suggest the presence of a mass with the potential for metastasis, such as evidence of cell motility or entry into blood vessels?"]}}, "whole body": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display multiple organ systems such as the nervous or circulatory system?", "Can you identify regions like the head, neck, thorax, or limbs in the image?", "Is there evidence of tissues such as muscle or nervous tissue distributed throughout the structures shown?", "Does the image contain organs like the heart, lungs, or kidneys?", "Are there visible anatomical structures that connect different regions, such as blood vessels or nerves?", "Can you see cavities such as the thoracic or abdominal cavity represented in the image?", "Is there visual evidence of integration among different organ systems?", "Does the image show cell types like neurons or muscle cells distributed across various regions?", "Are major body parts such as the trunk, upper limbs, or lower limbs present?", "Can you identify structures that link the internal environment to the outside, such as skin or sensory organs?"], "contexual_behavior": [], "functions": ["Does the image show an entity capable of survival and adaptation to its environment?", "Can you identify a structure that integrates multiple organ systems to maintain homeostasis?", "Is there evidence of coordinated physiological processes involving both nervous and endocrine systems?", "Does the image depict features associated with stress response mechanisms, such as those mediated by the hypothalamic-pituitary-adrenal axis?", "Can you see indications of thermoregulation, such as sweating or shivering?", "Is there a visible integration of skeletal muscles, bones, and joints supporting movement or locomotion?", "Does the image include elements involved in immune defense, such as tissues participating in innate or adaptive immunity?", "Can you identify features related to metabolic regulation or energy balance, such as indicators of nutrient storage or mobilization?", "Is there evidence of fluid or electrolyte homeostasis, possibly involving renal structures?", "Does the image show processes or structures responsible for waste elimination, such as those involved in urination, defecation, respiration, or perspiration?", "Can you see signs of growth or development, potentially influenced by hormonal signaling or nutrient supply?", "Is there evidence of gas exchange, such as the integration of respiratory and circulatory system features?", "Does the image suggest regulation of hormones through coordinated activity of endocrine glands or feedback loops?", "Can you identify features associated with immune surveillance or inflammation in response to infection?", "Is there evidence of physiological or behavioral adaptation to environmental changes?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure that could pose a risk to the lung, pleura, or mediastinum?", "Does the image reveal enlargement or involvement of hilar or mediastinal lymph nodes?", "Are there lesions defined by lobar fissures, pleural surfaces, or bronchovascular bundles?"], "contexual_behavior": ["Does the image suggest a tumor that fails to evade immune detection in a host with intact adaptive immunity?", "Does the image show a lesion with reduced proliferation following exposure to cytotoxic chemotherapy agents?", "Does the image show impaired tumor growth in the presence of cytokines like interferon-gamma or tumor necrosis factor-alpha?"], "functions": []}}, "beckwith-wiedemann syndrome": {"yes_questions": {"contexual_properties": ["Is there evidence of organ enlargement that could have developed before or shortly after birth?", "Does the image show signs of increased birth weight or fetal overgrowth?", "Can you identify asymmetric limb growth that might be present from birth or early childhood?", "Is there an enlarged tongue visible, particularly in a newborn or infant?", "Does the image reveal any abdominal wall defects, such as omphalocele or umbilical hernia, that are apparent at birth?", "Are there indications of low blood glucose, especially in a neonate?", "Can you see signs of kidney enlargement that may be present prenatally or in early childhood?", "Is there any facial appearance suggestive of midface hypoplasia or prominent eyes in an infant?", "Does the image suggest a predisposition to embryonal tumors, especially in a child?", "Are there visible changes in organ structure, such as altered tissue architecture or cellular overgrowth, in early development?", "Can you detect abnormal ear creases or pits, such as posterior helical pits, present at birth?", "Is there evidence of accelerated somatic growth, particularly in the prenatal or early postnatal period?", "Does the image suggest increased amniotic fluid volume, which might be detected during pregnancy?", "Can you see signs of an enlarged placenta during pregnancy?", "Are there indications of abnormal tissue composition, such as increased mesenchymal tissue or organ hyperplasia, in early life?"], "properties": ["Does the image show an individual with features such as excessive body size or rapid linear growth during infancy?", "Is there evidence of a tongue that appears unusually large compared to the oral cavity?", "Can you identify any organs that appear enlarged relative to typical pediatric anatomy?", "Is there asymmetry in limb or body size suggestive of hemihyperplasia?", "Does the abdominal region display signs of wall defects, such as an omphalocele or umbilical hernia?", "Is the birth weight or overall size of the infant above the 90th percentile for age and sex?", "Does the head circumference appear disproportionately large, possibly exceeding the 90th percentile?", "Are there facial features such as midface hypoplasia, prominent eyes, or visible ear creases or pits?", "Can you observe any signs of nephromegaly, such as visibly enlarged kidneys?", "Is there evidence of tall stature in the child, with height above the 90th percentile for age?", "Does the image suggest the presence of tumors such as Wilms tumor or hepatoblastoma?", "Are there visual indications of neonatal hypoglycemia, such as lethargy or abnormal feeding behavior?", "Can you see any laboratory findings or annotations indicating elevated insulin levels or abnormal methylation at the 11p15 region?", "Is there an umbilical hernia or omphalocele present in the abdominal area?", "Are there any visible signs of organomegaly affecting multiple organs?", "Does the image show a child with features that typically present at birth or in the neonatal period?", "Are there ear creases or pits visible on the external ear in the image?", "Is there evidence of both macroglossia and organomegaly in the same individual?"], "relational": ["Does the image show evidence of overgrowth in soft tissue, muscle, or connective tissue?", "Can you identify any asymmetry in the limbs or face suggestive of hemihyperplasia?", "Is there visible enlargement of the tongue or other features consistent with macroglossia?", "Does the image reveal abnormalities in the abdominal wall, such as incomplete closure or omphalocele?", "Are there signs of visceromegaly, such as an enlarged abdomen or prominent abdominal organs?", "Can you see any features indicating enlargement of the kidneys, liver, or limbs?", "Is there evidence of structural changes in the ear, such as creases or pits?", "Does the image suggest increased size or abnormal appearance of the pancreas or adrenal glands?", "Are there visual cues of altered tissue growth regulation in the musculoskeletal or lymphatic systems?", "Can you observe any changes in embryonic-derived structures, such as the abdominal wall or somatic tissues?", "Is there any indication of tumor risk in abdominal organs like the kidneys or liver?", "Does the image show involvement of multiple organ systems, such as endocrine, digestive, or genitourinary systems?", "Are there visible changes in the face, abdomen, or limbs that could be associated with a congenital overgrowth syndrome?"], "contexual_behavior": ["Does the image show evidence of abnormal growth regulation during fetal development or early childhood, possibly due to disruptions in imprinted gene expression?", "Is there a visible indication of increased risk for embryonal tumors, such as Wilms tumor or hepatoblastoma, particularly in a child?", "Can you identify features suggestive of metabolic dysfunction in infancy, such as signs of hypoglycemia or pancreatic islet cell hyperplasia?", "Does the image display signs of persistent hypoglycemia or disrupted glucose homeostasis during the neonatal period or early infancy?", "Is there evidence of organ overgrowth affecting the liver, kidneys, or tongue during prenatal development or early childhood?", "Can you see indications of abnormal hormone secretion in infancy or childhood, such as increased insulin production or pancreatic beta-cell hyperplasia?", "Does the image suggest postprandial hypoglycemia or impaired blood sugar regulation after feeding in a newborn?", "Is there any sign of susceptibility to hypoglycemia during fasting in a newborn or infant, possibly due to dysregulated insulin secretion?", "Can you identify features that might indicate metabolic instability or increased risk of hypoglycemia in response to surgical stress at any age?", "Does the image show structural anomalies such as nephromegaly or adrenal cytomegaly, suggesting altered kidney or adrenal gland function during childhood?", "Is there any evidence of secondary effects on the immune system during early development, even if immune dysfunction is not the primary feature?", "Can you observe signs of altered growth factor response, such as changes in IGF2 expression, affecting development?", "Does the image reveal abnormal placental function during pregnancy, such as placentomegaly or related complications?", "Is there any indication of impaired wound healing or tissue regeneration in a child, possibly due to altered cellular proliferation or growth factor signaling?", "Can you see signs of increased metabolic rate or anabolic activity during childhood, potentially associated with organ overgrowth?", "Does the image suggest impaired regulation of cell proliferation during embryonic or early postnatal development, possibly due to loss of imprinting at growth-regulating loci?", "Is there evidence of altered defense against oxidative stress during early life, even if this is not a primary clinical feature?", "Can you identify features of hepatomegaly or metabolic disturbances affecting liver function during neonatal development?", "Does the image show generalized or organ-specific overgrowth in infancy or childhood, indicating increased anabolic activity?", "Is there any indication of reduced effectiveness of normal growth suppression mechanisms throughout development, possibly due to epigenetic alterations affecting growth-regulatory genes?"], "functions": ["Does the image show evidence of generalized overgrowth or organ enlargement?", "Can you identify any signs of abnormal growth regulation, such as excessive prenatal or postnatal size?", "Is there visual evidence of metabolic imbalance, such as features suggestive of neonatal hypoglycemia?", "Does the image display enlargement of specific organs, such as the tongue, kidneys, or liver?", "Can you see any indications of abnormal insulin secretion or altered growth factor signaling?", "Is there evidence of increased cellular proliferation or abnormal tissue growth?", "Does the image suggest a predisposition to embryonal tumors, such as Wilms tumor or hepatoblastoma?", "Are there features consistent with glucose dysregulation, particularly in a neonatal context?", "Can you observe abnormal growth patterns or asymmetry in organ development?", "Is there visual evidence of altered sensitivity to growth signals, possibly due to changes in growth factor pathways?"]}, "no_questions": {"contexual_properties": ["Can you observe an increase in the measurable volume of an organ or tissue, potentially due to expansion of cell populations?", "Does the image show an area where the number of cells seems increased, possibly due to stimulated mitotic activity?", "Can you see any swelling or expansion in a tissue area that might be caused by an increased cell mass?"], "properties": ["Do you observe preserved tissue architecture in a region with increased cellularity?", "Is there an area where the nuclear-to-cytoplasmic ratio of cells appears normal, despite increased cell numbers?", "Can you identify an area where parenchymal or epithelial cells appear more numerous than usual?"], "relational": ["Does the image show a region within epithelial or glandular tissue where there appears to be an increased number of cells while maintaining normal tissue organization?", "Can you identify a structure within the prostate, endometrium, thyroid, or skin that appears enlarged due to cellular proliferation?", "Can you identify a region where the extracellular matrix appears to support an increased population of cells within a defined tissue border?"], "contexual_behavior": ["Is there a reduction in abnormal tissue proliferation following the resolution of inflammation?", "Do you observe a decrease in abnormal tissue growth following successful treatment or removal of a causative agent, such as an infectious organism or tumor?", "Is there a lack of tissue regeneration in areas that have sustained injury, suggesting impaired cellular response or stem cell dysfunction?"], "functions": ["Does the image show compensatory growth, such as expansion of cell populations to restore organ mass or function?", "Does the image suggest enhanced or disrupted organ function due to an increase in cell numbers?", "Does the image display signs of tissue remodeling or cellular response to physiological demands?"]}}, "kidneys": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the urinary system?", "Can you identify an organ located in the retroperitoneal space of the abdominal cavity?", "Is there a structure anatomically adjacent to the adrenal glands, liver, spleen, or intestines?", "Does the image contain an object connected to blood vessels such as the renal artery or renal vein?", "Can you see a structure linked to ducts or tubes like the ureters?", "Is there an organ supported or surrounded by features such as a capsule, perirenal fat, or fascia?", "Does the image display a structure composed of regions like the cortex, medulla, renal pyramids, or renal pelvis?", "Can you identify an object containing specialized cells such as podocytes or tubular epithelial cells?", "Is there a structure that interacts with the ureters, bladder, or urethra in the process of urine formation or excretion?", "Can you see an organ with the adrenal gland positioned directly superior to it?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Is there displacement of anatomical structures that could be due to a mass, hernia, or extrinsic compression?", "Are strictures apparent that might result from chronic inflammation, radiation injury, or a neoplastic process?", "Can you see any outpouchings along the gastrointestinal tract, as might be present in diverticula or Meckel's diverticulum?"], "properties": ["Does the image suggest the use of a preparation containing suspending agents, preservatives, or flavoring agents?", "Does the image suggest the use of a contrast agent with a viscosity ranging from 30 to 1000 centipoise?", "Does the image imply the use of a suspension with barium sulfate particles smaller than 15 micrometers?"], "relational": ["Does the image show any part of the digestive system being examined using a contrast agent?", "Does the image appear to be part of a radiologic imaging or contrast radiography procedure?", "Can you identify structures belonging to the gastrointestinal tract that are highlighted for assessment?"], "contexual_behavior": ["Does the image suggest delayed or absent progression of contrast, which might indicate a bowel obstruction?", "Is there impaired contrast coating or mucosal irregularity that might be explained by edema or ulceration from mucosal inflammation?", "Are there artifacts or residual air present that might reduce the effectiveness of imaging following a recent endoscopic procedure?"], "functions": ["Does the image allow evaluation of gastric emptying by showing the passage of a contrast agent from the stomach into the duodenum?", "Does the image show a procedure used to visualize the structure and function of the gastrointestinal tract?", "Does the image reveal any structural abnormalities of the digestive tract, such as strictures, ulcers, or masses highlighted by a contrast agent?"]}}, "diastasis recti": {"yes_questions": {"contexual_properties": ["Does the image show a separation between the left and right sides of the rectus abdominis muscle?", "Can you identify an abnormal gap along the midline of the abdominal wall?", "Is there evidence of a widened linea alba in the abdominal region?", "Does the image display a condition where the rectus muscles are not closely approximated at the midline?"], "properties": ["Is there a visible separation along the midline of the abdominal wall that appears wider than 2 centimeters?", "Can you identify a gap extending from the lower end of the sternum to the pubic region, possibly measuring between 10 and 25 centimeters in length?", "Does the image show a midline space whose depth varies and may appear deeper in more severe cases?", "Is there evidence that the connective tissue at the midline is thinner than usual, possibly less than 2 millimeters?", "Can you observe signs of reduced tensile strength in the abdominal wall, such as sagging or decreased firmness?", "Does the connective tissue in the midline appear less elastic, with increased laxity or less recoil?", "Is there a visible bulge or ridge along the midline of the abdomen, especially when the subject is straining?", "Can you see areas where the connective tissue and the midline structure appear stretched or attenuated?", "Does the image suggest that the intra-abdominal pressure at rest is within the normal range of 5 to 7 mmHg?", "Is there a reduction in the tone of the muscles running vertically along the abdomen, possibly due to separation?", "Can you detect changes in the organization or content of collagen in the midline connective tissue?", "Does the skin over the midline of the abdomen appear stretched, thinned, or marked with striae?", "Is the distance between the vertical abdominal muscles at the level of the navel greater than 2 centimeters?"], "relational": ["Does the image show a condition affecting the midline of the anterior abdominal wall?", "Can you identify a separation between paired muscles that run vertically along the abdomen?", "Is there visible widening or thinning of the connective tissue that lies between the rectus abdominis muscles?", "Does the image display an abnormal gap in the region associated with the linea alba?", "Can you see evidence of altered alignment or spacing of the rectus abdominis muscles?", "Is there a disruption in the continuity of the abdominal fascia at the midline?", "Are there signs of separation involving layers of the anterior abdominal wall?", "Does the image show changes in the relationship between the rectus abdominis and adjacent muscles such as the transversus abdominis or obliques?", "Can you observe any abnormal distance between the left and right rectus abdominis muscles?", "Is there a visible alteration in the area bordered by the external oblique and internal oblique muscles?", "Does the image suggest involvement of both the musculoskeletal and digestive systems in the abdominal region?", "Are the peritoneal or abdominal cavities adjacent to the region of interest in the image?"], "contexual_behavior": ["Is there evidence of impaired core muscle function during physical activity, such as difficulty with coordinated muscle engagement?", "Does the image suggest that increased intra-abdominal pressure, for example from coughing or lifting, could exacerbate the stretching of the connective tissue along the midline?", "Can you identify reduced support of the abdominal wall, particularly in the context of pregnancy where muscle and connective tissue stretching may be present?", "Is there a sign of decreased trunk stability or persistent muscle weakness following childbirth?", "Does the image indicate altered breathing mechanics during exertion, possibly due to a weakened abdominal wall?", "Is there disruption in the continuity of the abdominal muscles that could impair force transmission across the trunk?", "Can you observe signs that might contribute to lower back pain during movement, such as insufficient core support?", "Does the image show features that could affect posture during prolonged standing, for example, weakened abdominal muscles failing to maintain spinal alignment?", "Is there visual evidence suggesting limited ability to perform heavy lifting due to compromised abdominal integrity and reduced core stabilization?", "Can you see indications that the effectiveness of abdominal bracing during exercise might be reduced because of muscle separation?", "Does the image suggest interference with normal bowel or bladder function under strain, possibly due to a weakened abdominal wall unable to support pelvic organs?", "Are there signs that targeted physical therapy could improve the condition by strengthening the deep core and promoting tissue healing?", "Is there an increased risk of hernia formation during physical stress, such as protrusion of abdominal contents through a compromised midline structure?", "Does the image suggest impaired recovery of abdominal function after surgery, for example, delayed healing or muscle rehabilitation due to pre-existing separation?", "Can you observe features that might affect pelvic floor muscle coordination during daily activities, such as altered abdominal mechanics disrupting synergistic muscle activation?"], "functions": ["Does the image show evidence of reduced core strength or instability in the trunk region?", "Can you identify a separation between the left and right rectus abdominis muscles?", "Is there a visible impairment in the coordination or force transmission of the abdominal muscles?", "Does the image suggest postural changes such as increased lumbar lordosis or altered spinal alignment?", "Can you observe signs of reduced efficiency in trunk flexion or extension?", "Is there any indication of disrupted intra-abdominal pressure regulation or difficulty stabilizing the trunk during movement?", "Does the image suggest altered breathing mechanics due to limited support of the abdominal wall for diaphragmatic movement?", "Can you see signs of decreased support for pelvic organs, such as increased risk of pelvic floor dysfunction or organ prolapse?", "Is there visual evidence of reduced functional strength of the abdominal wall that could impair physical performance?", "Does the image indicate difficulty with activities requiring lifting or straining, or an increased risk of hernia or injury?"]}, "no_questions": {"contexual_properties": ["Do you observe regions where the overall luminance is abnormally high or low, suggesting abnormal brightness?", "Is there a noticeable loss of fine structures or details, possibly due to compression, low resolution, or blurring?", "Are there shadows present in locations that do not correspond to the expected direction of illumination?"], "properties": ["Is there an entity present whose file size would depend on its resolution, color depth, and compression?", "Can you see something whose height in pixels might be 600, 1080, or 2160?", "Can you find an object with an aspect ratio like 4:3 or 16:9?"], "relational": ["Does the image show proximity or overlap between neighboring organs?", "Is there a visible organ such as the heart or kidneys in the image?", "Can you see anatomical relationships that suggest the presence of surrounding tissues?"], "contexual_behavior": ["Are there visible artifacts suggesting patient movement that might obscure anatomical details?", "Is there evidence of metallic implants causing artifacts that could obscure underlying tissues and hinder early disease detection?", "Does the image suggest challenges in clarity or depth that might be encountered in obese patients during image-guided interventions?"], "functions": ["Can you identify any documentation of clinical findings within the image?", "Is there information in the image that could facilitate image-guided minimally invasive procedures?", "Can the image be used for disease screening or early detection of asymptomatic conditions?"]}}, "head": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with an ovoid or ellipsoid shape?", "Can you identify an object whose size could be approximately 22 cm in length and 17 cm in width in adults?", "Is there a structure present that might weigh around 4.5 to 5 kg in an adult?", "Can you see something with a circumference likely between 54 and 58 cm?", "Does the image contain an object with an estimated volume of about 1.3 to 1.5 liters?", "Is there a visible area where the skin color ranges from pale to dark brown depending on pigmentation?", "Can you identify a region where the bone density could be around 1.5 to 2.0 g/cm\u00b3?", "Is there a structure that might contain about 70% water by weight?", "Can you see an area where fat content could account for 10% to 15% of total weight?", "Does the image show a region where the scalp thickness is likely between 5 and 7 mm?", "Is there a structure composed of bone, muscle, skin, nervous tissue, connective tissue, and adipose tissue?", "Can you identify an area where the temperature would be approximately 36.5 to 37.5\u00b0C?", "Does the image show a region with dense hair, possibly 200 to 300 hairs per cm\u00b2?", "Is there a structure that could contain minerals such as calcium, phosphorus, and magnesium in its bony component?", "Can you see an area where the skin pH might be between 4.5 and 5.5?", "Is there a structure that could be made up of 22 bones in an adult?", "Can you identify a region with high oxygen consumption, likely due to brain metabolism?", "Does the image show an area with a high concentration of sensory receptors, especially in the lips or tongue?", "Is there a structure that receives significant blood flow, approximately 750 ml/min?", "Can you see a region where the proportion of gray to white matter might be about 1.3:1?"], "relational": ["Does the image show a region containing components of the nervous system?", "Is there a structure present that includes elements of the musculoskeletal system?", "Can you identify an area that contains organs of the sensory system?", "Does the image include any part of the respiratory or digestive systems within a single region?", "Are there visible bones such as the cranium, mandible, or maxilla?", "Can you see features corresponding to the zygomatic, nasal, or temporal bones?", "Is there a region that includes the occipital, parietal, or frontal bones?", "Does the image show a compartment that could contain the brain?", "Are there visible structures corresponding to the eyes, ears, or nose?", "Can you identify an area that might contain the tongue or salivary glands?", "Is there a region that could be classified as the cranial cavity, facial region, or oral cavity?", "Does the image show an area that could be the nasal or orbital cavity?", "Are there muscles present such as the masseter, temporalis, or frontalis?", "Can you see features corresponding to the orbicularis oculi, orbicularis oris, or buccinator muscles?", "Is there evidence of nerves such as cranial nerves, trigeminal nerve, or facial nerve passing through this region?", "Does the image show structures that could be innervated by the optic, olfactory, glossopharyngeal, or vagus nerves?", "Are there visible blood vessels such as the carotid arteries, vertebral arteries, or jugular veins?", "Can you identify arteries like the facial artery or superficial temporal artery in the region?", "Is there a connection to the neck via structures such as the atlanto-occipital joint or foramen magnum?", "Does the image show features that could be associated with cervical vertebrae or neck muscles?", "Are there sensory organs such as the eyes, ears, nose, or tongue present in the region?", "Can you see cavities such as the cranial cavity, nasal cavity, oral cavity, or orbital cavity?", "Is there evidence of the middle ear cavity or paranasal sinuses in the image?"], "contexual_behavior": ["Does the image show a structure that would exhibit reduced sensory processing during sleep in the NREM stages?", "Is there evidence of impaired coordination that could result from disrupted neural pathways after a traumatic injury?", "Can you identify a region where increased blood flow might occur during cognitive activity to meet metabolic demands?", "Does the image contain a structure that could lose its ability to regulate temperature in the event of heatstroke due to hypothalamic dysfunction?", "Is there a feature that could experience altered pain perception during a migraine as a result of trigeminovascular pathway sensitization?", "Can you see an area where neural activity would decrease under anesthesia due to suppressed central nervous system signaling?", "Is there a structure that might fail to maintain balance after vestibular dysfunction involving the inner ear or brainstem pathways?", "Does the image show a region where intracranial pressure could increase during infection as inflammation and edema develop?", "Is there a part that could demonstrate impaired speech production after a stroke affecting language centers?", "Can you identify an area that would show reduced oxygen supply in hypoxic conditions when arterial oxygen levels fall?", "Is there a structure that might alter its sensory integration during sensory overload due to overstimulated neural circuits?", "Does the image show a region that could experience diminished reflex responses as neuronal degeneration progresses in neurodegenerative disease?", "Is there a part that would increase metabolic demand during mental stress as neuronal activity and glucose consumption rise?", "Can you see evidence of impaired eye movement coordination that could result from disruption of oculomotor pathways after concussion?", "Is there a region that could show impaired thermoregulation in hypothalamic disorders when temperature control centers are affected?"], "functions": ["Does the image show a structure that houses multiple sensory organs such as those for vision, hearing, smell, taste, or touch?", "Can you identify a region that protects a major neural organ within a bony cavity?", "Is there a part visible that enables communication through speech or facial expressions?", "Does the image contain structures responsible for sensory integration, such as eyes, ears, nose, tongue, or skin?", "Can you see evidence of a bony structure that safeguards neural tissue?", "Is there a region that facilitates feeding and swallowing by coordinating the mouth, jaws, tongue, or pharynx?", "Does the image include features associated with balance and orientation, such as the vestibular system or inner ear?", "Can you identify an area that assists with breathing or olfaction by containing a nasal cavity or respiratory passages?", "Is there a structure that enables facial expression via the action of muscles controlled by cranial nerves?", "Does the image show components involved in hearing, such as the auricle, tympanic membrane, or cochlea?", "Can you see organs responsible for vision and eye movement, including extraocular muscles or the optic nerve?", "Is there evidence of taste sensation through the presence of a tongue or palate?", "Does the image reveal structures that contribute to speech production, such as the larynx, vocal cords, tongue, lips, or jaw?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see any foramina such as the hypoglossal canal or condylar canal in the depicted bone?", "Is there a structure through which the hypoglossal nerve (cranial nerve XII) could pass?", "Can you identify occipital condyles that would articulate with the first cervical vertebra?"], "contexual_behavior": ["Does the image show a cranial structure whose ability to protect the brain may be compromised following trauma or fracture?", "Is there evidence of a bone in the posterior skull region where reduced mineral density could indicate compromised structural support, as seen in osteoporosis?", "Can you identify a region of the skull where a fracture might alter cranial stability due to loss of bone continuity?"], "functions": ["Can you identify a region that shields the occipital lobes from injury?", "Does the image show a bone that articulates with the parietal, temporal, and sphenoid bones to maintain cranial stability?", "Is there a structure enclosing the foramen magnum?"]}}, "web neck": {"yes_questions": {"contexual_properties": ["Does the image show a neck region with increased width that could be associated with congenital anomalies or lymphatic malformations?", "Is there evidence of a neck structure that appears more pronounced, possibly indicating a genetic disorder such as Turner syndrome?", "Can you observe swelling or edema in the neck area that might suggest acute lymphedema or inflammation?", "Is there visible discoloration in the neck region that could be due to bruising, vascular changes, or underlying skin conditions?", "Does the neck display increased skin folds that might be related to connective tissue disorders or obesity?", "Can you see changes in skin texture on the neck that could result from chronic lymphedema or repeated skin infections?", "Is there a reduction in the thickness or prominence of the neck region that might indicate surgical correction or edema reduction?", "Does the neck area appear less prominent, possibly due to surgical intervention or age-related skin tightening?", "Can you identify changes in skin elasticity in the neck that might be associated with aging or connective tissue diseases?", "Is there evidence of abnormal tissue composition, such as fibrosis or adipose tissue accumulation, in the neck region?", "Does the neck appear edematous, suggesting lymphatic obstruction or ongoing inflammatory processes?", "Are there signs of fibrotic changes in the neck that could be due to chronic inflammation or previous surgical procedures?", "Can you observe a change in the length of the neck region that might be related to growth or surgical reconstruction?", "Is there visible pigmentation change on the neck that could be caused by chronic irritation, sun exposure, or dermatological conditions?", "Does the neck appear thickened, possibly as a response to chronic lymphedema or fibrotic remodeling?"], "properties": ["Does the image show a neck region that appears wider than average, possibly by several centimeters?", "Can you identify lateral skin folds extending from the area behind the ear to the tip of the shoulder?", "Is there a structure where the skin thickness resembles that of typical cervical skin, around 1.5 to 2.5 millimeters?", "Does the neck display broad, laterally extended, and posteriorly sloping skin folds?", "Is the skin color in the lateral neck region similar to adjacent areas, appearing flesh-colored or slightly darker?", "Can you observe skin in the neck area that appears smooth but may also look redundant or slightly wrinkled?", "Is there evidence of excess or overlapping skin folds along the side of the neck?", "Does the region between the mastoid process and the acromion show a continuous web-like extension?", "Can you see signs of reduced skin elasticity in the lateral neck, possibly due to underlying connective tissue changes?", "Is there an indication of increased or abnormally distributed collagen in the skin of the neck folds?", "Does the subcutaneous tissue in the lateral neck appear mildly increased in fat content?", "Is the water content of the skin in the neck region consistent with normal physiological levels?", "Can you estimate if the distance from the mastoid process to the acromion exceeds 10 centimeters?", "Does the skin in the lateral neck area appear to have normal vascularity, with no obvious increase or decrease in blood supply?", "Are tissues such as skin, subcutaneous fat, connective tissue, or fibrous bands visible within the lateral neck folds?"], "relational": ["Does the image show prominent lateral skin folds in the neck region?", "Is there evidence of pterygium colli present in the lateral or posterior neck?", "Can you identify thickened tissue or fibrous bands along the sides or back of the neck?", "Is there an abnormality affecting the musculoskeletal system in the lateral neck area?", "Does the image display features that could impact the lymphatic system near the cervical region?", "Are the superficial or posterior cervical lymph nodes visible or displaced in the neck?", "Can you see any changes in the skin or subcutaneous connective tissue along the lateral neck?", "Is there a structure that appears anatomically contiguous with the cervical vertebrae and extends laterally?", "Are the trapezius or sternocleidomastoid muscles adjacent to a region of abnormal skin folding?", "Does the image include the platysma muscle near an area of thickened or folded skin?", "Are the clavicles or cervical vertebrae associated with an unusual tissue extension in the neck?", "Is there a feature in the neck region that could be associated with Turner syndrome or Noonan syndrome?"], "contexual_behavior": ["Does the image show a cervical region where skin folds or fibrous tissue might restrict movement, especially during periods of rapid growth?", "Can you identify a neck structure where redundant skin or tissue could compress lymphatic vessels and potentially reduce lymphatic drainage in certain postures?", "Is there evidence of excess tissue in the upper neck that could encroach on the airway, particularly when lying in a supine position during sleep?", "Does the lateral aspect of the neck appear to have folds that might limit extension, rotation, or flexion during physical activity?", "Can you see thickened tissue in the neck that could compress superficial veins or arteries and potentially alter blood flow during exercise?", "Is there a neck configuration that might increase susceptibility to recurrent respiratory infections due to impaired lymphatic drainage or airway narrowing?", "Does the image show tissue redundancy in the neck that could impinge on the pharynx or esophagus, possibly contributing to swallowing difficulties under stress?", "Is there visible tightness or restriction in the neck region that could exacerbate functional limitations during puberty or periods of rapid growth?", "Can you identify excess skin in the neck area that might hinder heat dissipation and impair thermoregulation in hot environments?", "Does the neck structure appear to compound structural or physiological deficits in the presence of other congenital anomalies, potentially worsening functional impairment?"], "functions": ["Does the image show evidence of limited neck mobility, such as restricted range of motion or visible skin folds?", "Can you identify excess skin or fibrous tissue in the neck region that might reduce lateral flexion or rotation?", "Is there a visible abnormality in head or neck posture, such as a forward head position, that could be due to restricted soft tissue mobility?", "Does the image suggest the presence of inelastic tissue bands affecting cervical spine biomechanics?", "Are there signs of superficial vein compression or venous congestion in the neck area?", "Can you observe features that might indicate impaired lymphatic drainage, such as localized swelling suggestive of lymphedema?", "Is there any indication of mild compromise to airway patency, without evidence of significant obstruction?", "Does the image suggest possible interference with swallowing or speech due to tissue impingement on pharyngeal or laryngeal structures?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify an area within the left hemibody or left anatomical compartments that appears affected?", "Is there a visible abnormality located lateral to the sagittal plane, specifically on the left hemisphere or left lateral aspect?", "Can you identify a region on the left lateral aspect of the body that appears different from the contralateral side?"], "contexual_behavior": [], "functions": ["Can you see involvement of a brain region associated with speech production or fluency deficits?", "Can you identify a structural abnormality that might cause verbal memory loss or short-term memory deficits?", "Does the image contain signs of an area that could lead to decreased sensation or numbness on the right side?"]}}, "lateral view of head": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling that could indicate edema, cellulitis, or a tumor?", "Can you observe any thickening of bone that might suggest disorders such as Paget\u2019s disease, chronic osteomyelitis, or fibrous dysplasia?", "Does the image show abnormal contours that could be due to craniofacial anomalies, fractures, or neoplastic processes?", "Is there a reduction in bone density that might be consistent with metabolic bone diseases like osteoporosis or hyperparathyroidism?", "Can you detect any asymmetry that could result from developmental disorders, trauma, or a space-occupying lesion?", "Is there visible soft tissue enlargement that may be related to infection, allergic reaction, or neoplastic infiltration?", "Do you see abnormal calcifications that could be associated with meningioma, vascular malformations, or chronic infections?", "Is there any indication of fractures, such as those of the skull, mandible, or facial bones, possibly due to trauma?", "Can you identify areas of increased opacity that might correspond to sinusitis, a neoplasm, or hemorrhage?", "Is there evidence of fluid levels within the sinuses that could suggest acute or chronic sinusitis or facial trauma?", "Do you observe bone loss that might be attributed to chronic infection, malignancy, or periodontal disease?", "Is there a visible abnormal mass that could represent a benign or malignant tumor, cyst, or abscess?", "Can you see displacement of anatomical structures that may result from trauma, expanding masses, or congenital anomalies?", "Are there changes in air spaces that could indicate sinus disease, trauma, or the presence of a mass?", "Do you notice abnormal bone growths that might be consistent with exostoses, osteomas, or bone-forming tumors?"], "properties": [], "relational": ["Does the image display anatomical regions such as the temporal, parietal, or zygomatic areas?", "Can you identify bones like the mandible, maxilla, or sphenoid bone in the image?", "Is there evidence of muscles such as the temporalis or masseter present in the depicted structures?", "Does the image show branches of cranial nerves like the facial or trigeminal nerve?", "Are facial features such as the external ear, cheek, or chin visible in the image?", "Can you observe the contours and relationships of cranial and facial bones from an external perspective?", "Does the image include vascular structures like the superficial temporal artery or external jugular vein?", "Are sensory organs such as the eye or nose present in the view?", "Can you identify soft tissues like skin, parotid gland, or subcutaneous tissue in the image?", "Is there a region in the image that overlies brain areas such as the temporal or occipital lobe?"], "contexual_behavior": ["Does the image show evidence of abnormal condylar translation or joint space narrowing that could indicate impaired jaw movement?", "Is there visible narrowing or collapse in the oropharyngeal region suggesting altered airway patency, as might be seen in sleep apnea?", "Can you identify mucosal thickening or opacification of the paranasal sinuses that would suggest reduced sinus ventilation?", "Does the image reveal deviations in skull shape or abnormal suture closure patterns that could indicate abnormal cranial growth?", "Is there malalignment of the dental arches or abnormal occlusal relationships that might point to impaired mastication?", "Can you see turbinate hypertrophy or narrowing of the nasal passages that could result in decreased nasal airflow?", "Does the image display delayed or incomplete movement of the hyoid bone or epiglottis, which might reflect changes in swallowing mechanics?", "Is there evidence of vertebral displacement or abnormal curvature suggesting altered cervical spine alignment?", "Can you observe abnormal positioning or movement of the tongue, palate, or jaw that could indicate impaired speech articulation?", "Does the image show joint space narrowing, erosions, or condylar deformities that would suggest reduced temporomandibular joint function?"], "functions": ["Does the image provide a perspective that reveals the spatial arrangement of organs responsible for vision, hearing, smell, and taste?", "Can you identify the anatomical pathways or exit points of nerves that pass through the skull and soft tissues from this viewpoint?", "Is there evidence of the alignment or movement of the jaw, teeth, or associated muscles involved in mastication?", "Does the image display the passage of air through structures such as the nasal cavity, pharynx, larynx, or trachea?", "Can you observe the coordination of the lips, tongue, soft palate, or larynx in relation to speech production?", "Is it possible to assess the oral cavity, pharynx, or esophagus during the swallowing process from this perspective?", "Does the image allow for the observation of facial muscles responsible for expressions or functional movements?", "Can you evaluate the movement or articulation of the temporomandibular joint during jaw opening or closing?", "Is there visibility of the external, middle, or inner ear structures involved in hearing or balance?", "Does the image permit assessment of airway openness by showing the relationship among the tongue, soft palate, and pharyngeal walls?"]}, "no_questions": {"contexual_properties": ["Can you observe increased bone density in the region of a cranial foramen, which could be associated with metabolic bone disorders or sclerosing dysplasias?", "Is there visible calcification around a skull base opening that might be due to chronic inflammation, metabolic disturbance, or aging?", "Can you detect changes in the size of a cranial foramen that could be attributed to growth, development, or pathological processes like bone dysplasia?"], "properties": ["Does the image suggest a reduction in the volume of a cranial opening by approximately 30% to 50%?", "Does the image show a structure at the cranial base that appears oval or irregular instead of round?", "Can you observe thickened bone or fibrous tissue at the site of a narrowed cranial opening?"], "relational": ["Can you identify any disruption in the anatomical connection between the skull and vertebral column at the large opening at the skull base?", "Are there visible changes to tissues like dura mater, bone, or connective tissue surrounding the large opening at the skull base?", "Is there evidence of compression or impingement on nerves such as the spinal accessory nerve or upper cervical spinal nerves near the craniovertebral junction?"], "contexual_behavior": [], "functions": ["Does the image suggest possible disruption of respiratory or cardiovascular regulation due to brainstem involvement?", "Is there a visible narrowing that could obstruct cerebrospinal fluid flow and increase the risk of hydrocephalus?", "Does the image show narrowing that could impede the passage of cranial nerves responsible for swallowing, vocalization, or shoulder movement?"]}}, "bilateral pelvic-ureteral strictures": {"yes_questions": {"contexual_properties": ["Is there evidence of narrowing in the tubular structures that could be explained by chronic inflammation or fibrosis?", "Can you identify any regions where the length of a tubular segment appears increased, possibly due to persistent injury or inflammation?", "Does the image show signs of upstream urine retention or swelling that might result from an obstruction in the urinary tract?", "Is there visible thickening of the wall in any ureteral segments, suggesting sustained inflammation or fibrotic tissue deposition?", "Can you observe areas where fibrous tissue seems to have replaced normal ureteral architecture, indicating chronic injury and tissue remodeling?", "Are there regions where the lumen diameter of a tubular structure is decreased, possibly due to tissue contraction and fibrosis?", "Does the image reveal any signs of hydronephrosis, such as dilation of the renal pelvis, that could result from impaired urine drainage?", "Can you detect calcification or dystrophic mineral deposits in any chronic or advanced lesions within the urinary tract?", "Is there evidence that a tubular structure has become more rigid, potentially due to collagen or extracellular matrix accumulation?", "Do you see any changes in the apparent flow of urine, such as decreased flow rate or pooling, that might be caused by luminal narrowing?", "Are there areas of mucosal ulceration or surface disruption, possibly associated with acute inflammation or ischemic injury?", "Can you identify irregularities or scarring on the mucosal surface of a ureteral segment, suggesting chronic remodeling?", "Is there visible tissue edema or swelling in the urinary tract, potentially related to acute inflammation or obstruction?", "Do you observe changes in tissue composition, such as loss of normal structure and increased fibrous tissue, within the ureteral wall?", "Are there regions with increased cellular infiltration, indicating an active inflammatory or immune response in the urinary tract?"], "properties": ["Does the image show segmental narrowing at the proximal ureter near the ureteropelvic junction on both sides?", "Can you identify bilateral structures with a length between 1 and 3 centimeters?", "Is there evidence of luminal reduction of 50% or more in the proximal ureteral segments?", "Does the image reveal areas with a diameter less than 4 millimeters in the proximal ureters?", "Are there regions where the wall thickness measures between 2 and 5 millimeters?", "Can you see segmental narrowing accompanied by proximal ureteral dilation on both sides?", "Is there a visible reduction in cross-sectional area to less than 10 square millimeters in any bilateral proximal ureteral segments?", "Do any bilateral proximal ureteral segments appear pale or whitish, suggesting fibrotic changes?", "Is there evidence of firm and irregular surface texture in the narrowed proximal ureteral regions?", "Can you identify areas with increased tissue density compared to normal ureteral tissue?", "Are there bilateral proximal ureteral segments that show moderate to severe fibrosis?", "Does the image suggest decreased vascularity in any narrowed proximal ureteral regions?", "Are there signs of reduced water content in the tissue of bilateral proximal ureteral segments?", "Can you detect regions with increased collagen and decreased elastin compared to healthy ureteral tissue?", "Is there a moderate to high concentration of inflammatory cells present in the narrowed bilateral proximal ureteral segments?", "Do the affected bilateral proximal ureteral regions appear to contain fibroblasts and myofibroblasts?", "Is the tissue pH in the narrowed bilateral proximal ureteral segments approximately neutral, around 7.0 to 7.4?"], "relational": ["Does the image show any abnormalities affecting both lower tubes that connect the kidneys to the bladder?", "Can you identify any changes in the structures that are part of the urinary system, specifically in the pelvic region?", "Is there evidence of narrowing or obstruction in the pelvic portions of both ureters?", "Does the image suggest impaired urine flow from both kidneys, possibly resulting in swelling of the upper urinary tract?", "Can you see any signs of urine retention or backflow near the junction where the tubes enter the bladder?", "Are there visible alterations in the walls of the lower ureters, such as thickening or irregularity?", "Does the image show any relationship between the affected structures and the surrounding connective tissue, smooth muscle, or pelvic fascia?", "Is there evidence of involvement of blood vessels such as branches of the internal iliac or vesical arteries near the lower ureters?", "Can you identify lymph nodes adjacent to the pelvic ureters, such as the external or internal iliac lymph nodes, that may be affected?", "Are there any changes in nearby urinary tract structures like the renal pelvis, bladder trigone, or urethra that could be related to obstruction in the lower ureters?"], "contexual_behavior": ["Does the image show evidence of a condition that causes narrowing of both ureters, potentially leading to obstruction of urinary outflow from the kidneys?", "Is there a visual indication of impaired urine drainage from both kidneys, such as dilation of the renal pelvis or ureters?", "Can you identify signs of increased pressure in the renal pelvis, which may suggest hydronephrosis due to urinary obstruction?", "Does the image suggest decreased urine flow from the kidneys, possibly resulting in waste retention or impaired excretion?", "Are there features consistent with reduced glomerular filtration rate, such as swollen kidneys or signs of increased intrarenal pressure?", "Is there visual evidence of impaired urine drainage that could be exacerbated during dehydration or after physical exertion?", "Can you see any signs that might indicate worsened kidney function in the presence of a urinary tract infection or inflammation?", "Does the image suggest decreased urine output despite signs of fluid overload, possibly due to bilateral urinary obstruction?", "Are there indications of chronic damage to the renal medulla, which could impair the kidneys\u2019 ability to concentrate urine?", "Can you identify features that might suggest electrolyte imbalance or impaired excretion of metabolic waste due to obstructive uropathy?", "Is there evidence of toxin accumulation or reduced renal clearance, such as enlarged kidneys or abnormal tissue appearance?", "Does the image show any features that could increase the risk of acute kidney injury, especially in the context of hypotension?", "Are there signs that the kidneys may be failing to regulate blood pressure, possibly due to impaired function from obstruction?", "Can you see any indications that drug excretion might be impaired, such as swelling or abnormal appearance of the urinary tract?", "Is there evidence that renal dysfunction could be exacerbated during pregnancy, such as increased urinary tract compression?", "Does the image suggest impaired recovery of kidney function after relief of an obstruction, such as signs of fibrosis or chronic damage?", "Are there features that indicate an altered response to diuretic therapy, such as persistent swelling despite treatment?", "Can you identify signs of worsening renal function in the context of chronic kidney disease, possibly due to additional urinary obstruction?", "Does the image show evidence of impaired acid-base balance regulation, such as changes in kidney structure associated with obstructive uropathy?", "Are there visual clues suggesting decreased renal perfusion, especially in the context of sepsis or systemic hypotension?"], "functions": ["Does the image show evidence of impaired urine drainage from the kidneys?", "Is there a visible narrowing at the pelvic junction of both tubes connecting the kidneys to the bladder?", "Can you identify signs of reduced urine flow from the kidneys to the bladder?", "Is there any indication of back pressure or potential damage to the tissue of the kidneys?", "Does the image suggest disruption of fluid or electrolyte balance due to impaired kidney excretion?", "Can you see signs of urine accumulation or dilation of the renal pelvis consistent with hydronephrosis?", "Is there evidence of urinary stasis that could increase susceptibility to infection?", "Does the image suggest impaired elimination of metabolic waste products or possible toxin retention?", "Are there features indicating elevated pressure within the urinary tract or upstream dilation?", "Can you identify signs of chronic obstruction or loss of nephron function leading to renal insufficiency?", "Is there evidence of decreased urine output or disruption of the body's homeostasis due to reduced excretion?"]}, "no_questions": {"contexual_properties": ["Does the image show evidence of a malignant neoplasm originating from a glandular organ in the male reproductive system that has spread to other tissues?", "Does the image contain features consistent with the spread of a glandular cancer beyond its organ of origin in the male genitourinary tract?", "Is there a lesion present that suggests secondary involvement by a cancer typically arising from the prostate?"], "properties": [], "relational": ["Does the image reveal lesions or changes in the bones, particularly in the axial skeleton?", "Is there evidence of disease affecting structures adjacent to the prostate, such as the bladder, rectum, seminal vesicles, or pelvic lymph nodes?", "Are there signs of abnormality in the lymph nodes, such as pelvic, obturator, internal iliac, or para-aortic nodes?"], "contexual_behavior": [], "functions": []}}, "ear lobe crease": {"yes_questions": {"contexual_properties": ["Is there a visible crease that appears deeper or more prominent in individuals with signs of aging or decreased skin elasticity?", "Can you identify a feature that is more noticeable in people with cardiovascular risk factors or as part of the natural aging process?", "Does the image show a crease with altered color, possibly indicating local trauma, bruising, or vascular changes?", "Is there a visible line that appears wider, potentially due to loss of subcutaneous fat or collagen?", "Can you see a crease present in both ears, which might be more common in older adults or those with systemic conditions?", "Is there a feature that becomes more visible with cumulative skin changes associated with increasing age?", "Does the image show a crease that appears less noticeable, possibly due to improved skin turgor or cosmetic procedures?", "Can you identify an asymmetrical crease that could be related to unilateral sleeping habits, trauma, or localized skin changes?", "Is there a visible line associated with thinning of the skin, possibly due to aging or dermatological disease?", "Does the crease show changes in texture that might be due to chronic sun exposure, skin disorders, or scarring?", "Is there swelling near a crease that could suggest local infection, allergic reaction, or trauma?", "Can you see a crease that appears to have developed suddenly, possibly following acute trauma or rapid changes in skin integrity?", "Does the image show a crease with discoloration that could be linked to bruising, vascular compromise, or pigmentation disorders?", "Is there a more pronounced crease that might be associated with dehydration and reduced skin turgor?", "Can you identify a crease that has changed in appearance following weight loss, possibly due to diminished subcutaneous fat?"], "properties": ["Is there a linear or diagonal marking visible across the anterior surface of the ear lobe, running from the tragus to the lower edge?", "Can you identify a shallow indentation, less than 1 millimeter deep, on the ear lobe?", "Does the image show a marking on the ear lobe that is between 1 and 2 centimeters in length?", "Is there a feature on the ear lobe that appears 1 to 3 millimeters wide?", "Can you see a marking on the ear lobe whose color matches the surrounding skin or is slightly darker?", "Does the texture of the ear lobe show a smooth but indented line compared to adjacent skin?", "Are there similar markings present on both ear lobes, suggesting a bilateral appearance?", "Is there a visible feature on the ear lobe that is more likely to appear in individuals over 40 years of age?", "Does the image show a marking on the ear lobe that is consistent with a feature found in 20\u201330% of adults?", "Can you identify whether the marking on the ear lobe is unilateral or bilateral, and if so, does it match the higher prevalence of bilateral cases?"], "relational": ["Is there a linear fold or indentation visible within the tissue of the auricle?", "Can you identify a superficial feature formed in the skin of the external ear?", "Does the image show a morphological variant located on the lower part of the auricular region?", "Is there a visible skin fold adjacent to the margin of the ear lobe and the cheek skin?", "Can you see a structure in the auricular region that contains epidermis, dermis, adipose tissue, and connective tissue?", "Does the image display a feature that could be supplied by branches of the posterior auricular or superficial temporal arteries?", "Is there a visible fold in the ear lobe area that might be innervated by the great auricular or auriculotemporal nerve?", "Can you identify a linear indentation among other features such as piercing sites or pigmentation spots on the ear lobe?"], "contexual_behavior": ["Does the image show a feature that becomes more pronounced in individuals with increased vascular aging or arterial stiffness?", "Is there a visible sign that may persist even after improvements in metabolic health due to underlying structural changes in connective tissue?", "Can you identify a feature that tends to deepen with aging as elastin and collagen fibers degrade?", "Does the image contain a characteristic that can appear or worsen in response to chronic stress and prolonged exposure to elevated cortisol?", "Is there a visible indicator that correlates with impaired microcirculation or compromised capillary blood flow?", "Can you see a feature that is more prominent in individuals with diabetes as a result of microvascular complications and connective tissue glycation?", "Does the image show a sign that may develop or progress during systemic atherosclerosis due to chronic arterial narrowing and reduced tissue perfusion?", "Is there a feature that could change in appearance after weight loss or lifestyle modification if vascular health and skin elasticity improve?", "Can you identify a characteristic that becomes less prominent following improved cardiovascular function and restored tissue perfusion?", "Does the image contain a visible sign that may indicate altered connective tissue behavior in metabolic syndrome due to changes in the extracellular matrix and chronic inflammation?"], "functions": ["Does the image show an anatomical variation that does not have a known function?", "Can you identify a visible feature that serves as an anatomical marker without participating in physiological processes?", "Is there a crease present that has been studied as a potential clinical indicator of increased cardiovascular risk?", "Does the image display a feature that may reflect alterations in vascular or connective tissue integrity?", "Can you see a structure that could be associated with age-related changes or microvascular pathology?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure present that appears pale, translucent, or white in color?", "Does the image show a mass with a grape-like or vesicular appearance?", "Does the image display tissue with diffuse swelling of villi and no visible blood vessels?"], "relational": ["Can you see a mass affecting the endometrial lining or myometrium?", "Is there involvement of the fallopian tubes or cervix by an abnormal intrauterine process?", "Does the image display proliferating cytotrophoblasts or syncytiotrophoblasts within a uterine mass?"], "contexual_behavior": [], "functions": ["Is there any indication of altered maternal immune tolerance or features that might suggest increased susceptibility to immune-mediated complications?", "Can you observe features consistent with diffuse trophoblastic hyperplasia and lack of normal villous differentiation?", "Can you identify areas where placental tissue appears to be replaced by swollen, cystic villi lacking visible fetal blood vessels?"]}}}
[ { "answer": "opened base of skull with brain", "extracted_concepts": [ "base of skull", "brain", "opened base of skull with brain" ], "question": "what removed?" }, { "answer": "yes", "extracted_concepts": [ "brain removed", "opened base of skull" ], "question": "is opened base of skull with brain removed?" }, { "answer": "no", "extracted_concepts": [ "narrowing of foramen magnum", "odontoid process subluxation" ], "question": "is odontoid process subluxation with narrowing of foramen magnum removed?" }, { "answer": "opened base of skull with brain removed", "extracted_concepts": [ "base of skull", "brain removed", "opened base of skull", "brain" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "brain removed", "opened base of skull" ], "question": "does this image show opened base of skull with brain removed?" }, { "answer": "no", "extracted_concepts": [ "brain removed", "opened base of skull" ], "question": "does side show opened base of skull with brain removed?" }, { "answer": "lesion", "extracted_concepts": [ "lesion", "right petrous bone" ], "question": "what seen on surface right petrous bone?" }, { "answer": "on surface right petrous bone", "extracted_concepts": [ "lesion", "right petrous bone" ], "question": "what is lesion seen?" }, { "answer": "yes", "extracted_concepts": [ "lesion", "right petrous bone" ], "question": "is lesion seen on surface right petrous bone?" }, { "answer": "no", "extracted_concepts": [ "right petrous bone" ], "question": "is interesting case seen on surface right petrous bone?" }, { "answer": "fibrous meningioma", "extracted_concepts": [ "fibrous meningioma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "fibrous meningioma" ], "question": "is fibrous meningioma present?" }, { "answer": "no", "extracted_concepts": [ "gastrointestinal" ], "question": "is gastrointestinal present?" }, { "answer": "lesion", "extracted_concepts": [ "lesion", "right petrous bone" ], "question": "what seen on surface right petrous bone?" }, { "answer": "opened base of skull with brain", "extracted_concepts": [ "base of skull", "brain" ], "question": "what removed?" }, { "answer": "fibrous meningioma", "extracted_concepts": [ "fibrous meningioma" ], "question": "what is present?" }, { "answer": "right", "extracted_concepts": [ "lesion", "petrous bone" ], "question": "how is lesion seen on surface petrous bone?" }, { "answer": "petrous", "extracted_concepts": [ "lesion", "surface right bone", "petrous" ], "question": "how is lesion seen on surface right bone?" } ]	["fibrous meningioma", "opened base of skull", "opened base of skull with brain", "right petrous bone", "petrous", "petrous bone", "brain removed", "gastrointestinal", "base of skull", "lesion", "surface right bone", "brain", "odontoid process subluxation", "narrowing of foramen magnum"]	{"fibrous meningioma": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a well-circumscribed, lobulated, or ovoid mass measuring between 1 and 5 centimeters in diameter visible in the image?", "Can you identify a structure with a firm and rubbery texture?", "Does the image show a mass with a grayish-white or tan coloration?", "Is there evidence of a lesion with high density due to abundant fibrous tissue?", "Can you see a tumor that appears to have low water content compared to surrounding tissues?", "Does the image reveal a structure with low to moderate vascular density?", "Is there a mass that displays scattered calcifications resembling psammoma bodies?", "Can you identify a lesion with a marked degree of fibrosis throughout?", "Does the image show a tumor composed of spindle-shaped cells and fibroblast-like cells?", "Is there a structure with a rich collagen fiber matrix and some reticulin present?", "Can you see a mass that would be expected to have a low mitotic index, with fewer than 4 mitoses per 10 high-power fields?", "Is there evidence of a lesion with low to moderate cellularity and a low to moderate nuclear-cytoplasmic ratio?", "Does the image suggest the presence of a tumor with finely granular and evenly distributed chromatin in its cells?", "Is there a mass that would likely show negative or very low S100 protein expression?", "Can you identify a structure that would be expected to have positive membranous staining for epithelial membrane antigen (EMA)?", "Does the image reveal a lesion with a Ki-67 proliferation index of less than 4%?"], "relational": ["Does the image show a mass that is external to the brain tissue but may compress or displace it?", "Can you identify a lesion that appears to arise from the outermost layer of the meninges?", "Is there a structure located adjacent to the dura mater, brain parenchyma, or inner surface of the skull?", "Does the image contain a mass that is part of the central nervous system?", "Can you see a lesion that could affect nearby cerebral cortex, cranial nerves, or blood vessels?", "Is there a mass that appears to be associated with meningeal arteries or dural veins?", "Does the image show a structure near the cranial vault, skull base, or falx cerebri?", "Can you identify a mass that may involve fibroblast-like or meningothelial cell populations?", "Is there evidence of a lesion primarily involving the dura mater layer of the meninges?", "Does the image reveal a mass with anatomical boundaries defined by the dura mater, adjacent brain tissue, or the inner skull surface?"], "contexual_behavior": ["Does the image show a mass that might exhibit increased cell proliferation in response to elevated growth factor signaling?", "Is there a structure present whose extracellular matrix production could be reduced following targeted therapy or exposure to matrix synthesis inhibitors?", "Can you identify a lesion that might display enhanced vascularization under hypoxic conditions due to upregulation of angiogenic factors such as VEGF?", "Does the image contain a tumor that could decrease its collagen synthesis when subjected to antifibrotic agents or metabolic stress?", "Is there evidence of a mass whose growth may be impaired as a result of radiation therapy or exposure to ionizing radiation?", "Can you see a lesion that might increase its invasion into surrounding tissues if matrix metalloproteinases are upregulated or cell adhesion molecules are lost?", "Is there a structure whose mitotic activity could be reduced under conditions of decreased progesterone or estrogen levels?", "Does the image show a tumor that may alter its growth rate during pregnancy due to hormonal fluctuations and increased blood flow?", "Can you identify a mass that might exhibit increased resistance to apoptosis in hypoxic regions through activation of survival pathways like HIF-1\u03b1?", "Is there a lesion that could show decreased responsiveness to immune surveillance when immune checkpoint molecules are expressed or in an immunosuppressive environment?", "Does the image contain a structure that might increase secretion of growth factors in response to inflammation via activation of inflammatory signaling pathways?", "Can you see a tumor whose metabolic activity could be reduced after chemotherapy due to cytotoxic effects and cellular stress responses?", "Is there evidence of a lesion whose behavior might be altered by genetic mutations affecting tumor suppressor genes or signaling pathways?", "Does the image show a mass that could increase fibrous tissue deposition under chronic stress by stimulating fibroblast activity and extracellular matrix production?", "Is there a structure whose angiogenic potential might be decreased after anti-angiogenic therapy through inhibition of vascular growth factor signaling?"], "functions": ["Is there evidence of a pathological growth of meningothelial cells in the image?", "Can you identify a mass that appears to compress or displace nearby brain tissue?", "Does the image show any signs of obstruction in cerebrospinal fluid pathways, such as enlarged ventricles or features suggestive of hydrocephalus?", "Is there a structure exerting pressure on regions of the brain that could lead to neurological deficits?", "Can you see any indication of compression or invasion of local blood vessels, such as areas of reduced perfusion or edema?", "Does the image reveal a space-occupying lesion that might increase intracranial pressure?", "Is there any visible evidence of compression or encasement of cranial nerves that could result in neuropathy?", "Can you detect signs of a localized immune response, such as peritumoral inflammation or lymphocytic infiltration?", "Is there any indication of disrupted neuronal pathways or interference with normal brain signaling?", "Does the image show reactive changes in adjacent tissues, such as gliosis or edema, in response to a nearby mass?"]}, "no_questions": {"contexual_properties": ["Is there a visible mass compressing the cranial opening, such as a meningioma or herniated brain tissue?", "Is there abnormal bone growth near the cranial base, as might occur in osteopetrosis or Paget\u2019s disease?", "Does the opening at the cranial base appear asymmetric, potentially due to congenital malformation, trauma, or unilateral bone disease?"], "properties": ["Is there an opening located at the base of the skull within the occipital bone?", "Can you identify a feature formed entirely by the occipital bone?", "Is there a feature whose area appears to be within the range of 700 to 900 square millimeters?"], "relational": ["Can you identify a structure located in the posterior cranial fossa of the skull?", "Is there a large opening within the occipital bone visible in the image?", "Is there a structure near the jugular tubercles in the posterior part of the skull?"], "contexual_behavior": ["Can you detect signs of bone erosion or weakening at the cranial base that could be caused by metastatic disease?", "Does the image show evidence of an opening at the base of the skull where cerebrospinal fluid flow might be obstructed during increased intracranial pressure?", "Does the image reveal signs of vascular structures, such as vertebral arteries or veins, being compressed by swelling, hemorrhage, or bone displacement after trauma?"], "functions": ["Is there a structure at the cranial base that encases and protects the lower brainstem and upper spinal cord within the skull?", "Does the image show a large opening at the base of the skull that serves as a passageway for the medulla oblongata?", "Is there an opening visible that allows neural tissue and meninges to pass from the cranial cavity into the vertebral canal?"]}}, "opened base of skull": {"yes_questions": {"contexual_properties": ["Is there evidence of increased bleeding that could suggest trauma or a vascular injury?", "Can you observe any abnormal bone erosion that might indicate infection or a neoplastic process?", "Does the image show discoloration that could be due to hemorrhage, bruising, or tissue necrosis?", "Is there visible swelling of tissues that may be associated with infection, inflammation, or edema?", "Can you identify signs of pus accumulation or infection, such as might be seen in osteomyelitis or an abscess?", "Does the image reveal areas of bone thinning that could be related to metabolic bone disease or chronic infection?", "Is there any abnormal tissue growth present that could correspond to a tumor, granuloma, or meningioma?", "Can you see fractures or bone fragments that might result from trauma, surgery, or pathological weakening?", "Does the image display regions of increased vascularity that could be associated with a tumor or arteriovenous malformation?", "Is there evidence of abnormal fluid accumulation, such as might occur with a cerebrospinal fluid leak, edema, or abscess?", "Can you observe changes in bone density that could suggest a metabolic disorder, chronic infection, or neoplastic infiltration?", "Does the image show areas of calcification that might be due to chronic inflammation, a tumor, or a metabolic condition?", "Is there any indication of bone softening that could be consistent with rickets, osteomalacia, or chronic infection?", "Can you detect abnormal color changes in the dura mater that might indicate infection, hemorrhage, or tumor infiltration?", "Does the image demonstrate loss of bone integrity that could result from severe trauma, infection, or advanced neoplastic disease?"], "properties": ["Does the image show a structure with an irregular, concave shape featuring multiple depressions and projections?", "Can you identify a bony area with a typical length of about 13 centimeters from front to back?", "Is there a region present that measures approximately 9 centimeters at its widest point?", "Does the image contain a structure whose overall size could be estimated between 12 to 15 centimeters in length and 8 to 10 centimeters in width?", "Can you see a bony surface that appears off-white to pale yellow in color?", "Is there a structure that seems to weigh between 150 and 250 grams based on its apparent size and density?", "Does the image include bone tissue composed of both compact and cancellous types, with a matrix containing collagen and hydroxyapatite?", "Can you identify a region where the bone thickness varies between 3 and 8 millimeters depending on the area?", "Is there a structure with a bone density estimated between 1.5 and 2.0 grams per cubic centimeter?", "Does the image show a hard, slightly porous bone with a rough internal surface?", "Can you see a bony structure with a surface area likely between 100 and 150 square centimeters?", "Is there evidence of mineral content, such as calcium and phosphate in the form of hydroxyapatite, making up about 65% of the bone mass?", "Can you identify a region where the water content of the bone might be around 20% by weight?", "Does the image display anatomical landmarks such as the foramen magnum, sella turcica, clivus, or the petrous part of the temporal bone?", "Are there visible foramina, including the foramen magnum, jugular foramen, carotid canal, foramen ovale, or foramen spinosum?"], "relational": ["Does the image show a region formed by bones such as the occipital, sphenoid, temporal, ethmoid, or frontal bones?", "Can you identify areas corresponding to the anterior, middle, or posterior cranial fossae?", "Is there evidence of large openings such as the foramen magnum or jugular foramen?", "Does the image display multiple foramina, including the foramen ovale, foramen spinosum, foramen rotundum, carotid canal, hypoglossal canal, or cribriform plate foramina?", "Can you see passageways that would allow cranial nerves, such as the olfactory or optic nerves, to traverse the structure?", "Is there a visible pathway for major blood vessels like the internal carotid artery or vertebral artery?", "Does the structure provide support for regions of the brain, such as the frontal lobes, temporal lobes, brainstem, or cerebellum?", "Are there attachment points for membranes like the dura mater, arachnoid mater, or pia mater?", "Can you identify features that form the inferior boundary of the cranial cavity and provide passageways for neurovascular structures?", "Is there a connection to the vertebral column through structures such as the foramen magnum or occipital condyles?", "Does the image show distinguishing features such as exposed fossae, visible foramina, or the absence of the calvaria and overlying soft tissues?", "Is the cranial floor directly visible, indicating an opened rather than intact skull base?"], "contexual_behavior": ["Does the image show a disruption of the bony floor that could expose neural structures to external injury?", "Is there evidence of a breach that might allow cerebrospinal fluid to escape from the cranial cavity?", "Can you identify a loss of anatomical continuity that would increase the risk of infection entering the intracranial space?", "Does the image reveal compromised bony margins around foramina, potentially making cranial nerves more vulnerable?", "Is there visible exposure or injury to blood vessels traversing the cranial cavity, suggesting a risk of hemorrhage?", "Can you see an opening that would prevent the cranial vault from maintaining normal intracranial pressure?", "Does the image show disruption of venous sinuses or emissary veins that could impair drainage of blood from the brain?", "Is there a loss of structural support that might increase the risk of abnormal brain displacement or herniation?", "Can you identify a breach in anatomical barriers such as the tentorium or falx, altering communication between cranial compartments?", "Does the image reveal abnormal connections between the cranial cavity and adjacent spaces, such as sinuses or nasal cavities, that could allow air or fluid to pass through?", "Is there evidence of reduced mechanical stability of the head, making it more susceptible to further trauma?", "Can you see a defect that would allow blood to escape from the cranial vault, reducing the containment of hemorrhage?", "Does the absence of a rigid cranial base suggest altered movement or deformation of brain tissue during head injury?", "Is there a disruption of the sella turcica that could affect the function or environment of the pituitary gland?", "Can you identify a pathway that would allow pathogens from the nasal or oral cavities to ascend into the cranial cavity due to loss of anatomical barriers?"], "functions": ["Does the image show a surgical approach that provides access to the cranial base for treating underlying pathologies?", "Can you identify a procedure that allows direct visualization of intracranial structures such as the brainstem or cranial nerves?", "Is there evidence of an intervention designed to expose deep-seated anatomical regions for tumor or lesion removal?", "Does the image depict a method that enables decompression of neural tissues by relieving pressure from swelling or masses?", "Can you see a surgical field that offers access to major blood vessels for vascular repair or hemostasis?", "Is there an indication of controlled cerebrospinal fluid drainage to manage intracranial pressure during surgery?", "Does the image include features consistent with trauma management, such as evacuation of hematomas or repair of cranial fractures?", "Can you identify an exposure that facilitates microsurgical repair of cranial nerve injuries?", "Is there visual evidence of a surgical approach aimed at improving lesion access, relieving symptoms, or restoring neurological function?", "Does the image show a procedure that enables drainage or debridement of infected tissue within the cranial cavity for infection or abscess management?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image contain an object whose thickness varies between 4 and 8 millimeters depending on the region?", "Can you identify an object that appears off-white or pale ivory due to mineralized bone tissue?", "Does the image show a structure with an oval or rounded shape and a slightly elongated anteroposterior axis?"], "relational": ["Is there evidence of cavities like the cranial, nasal, or orbital cavities?", "Does the image show a structure that is part of the skeletal system?", "Can you see any foramina, such as the optic canal or jugular foramen?"], "contexual_behavior": [], "functions": ["Does the image show a framework that supports sensory organs such as the eyes or ears?", "Is there a bony framework shaping the forehead, cheeks, or jaw?", "Does the image show structures forming the oral or nasal cavities, which facilitate speech resonance?"]}}, "opened base of skull with brain": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display an area where cranial fossae are exposed?", "Can you identify any major blood vessels traversing the base of the skull near the brain?", "Is there evidence of meninges covering the lower aspect of the brain?", "Are any cranial nerves visible as they pass through the base of the skull?", "Can you see bony structures such as the occipital, sphenoid, temporal, ethmoid, or frontal bones in relation to the brain?", "Are regions of the brain such as the frontal lobes, temporal lobes, brainstem, or cerebellum visible at the base of the skull?", "Does the image show any foramina, such as the foramen magnum or optic canal, at the base of the skull?", "Is there a visible structure that could be the internal carotid artery, vertebral artery, basilar artery, or internal jugular vein?", "Can you see coverings that might correspond to dura mater, arachnoid mater, or pia mater?", "Are the anterior, middle, or posterior cranial fossae distinguishable in the image?", "Does the image show any dural folds, such as the falx cerebri or tentorium cerebelli?", "Can you identify any structures that connect the brain to the base of the skull, such as cranial nerve roots or meningeal attachments?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides a stable platform accommodating the weight and shape of the brain?", "Can you identify a rigid barrier that protects the brain from mechanical injury?", "Is there evidence of openings that allow cranial nerves to exit or enter the brain?", "Does the image reveal channels or passages that could regulate blood flow to and from the brain?", "Can you see foramina or canals that might transmit nerves and blood vessels essential for brain function?", "Is there a structure that anchors or stabilizes the brain by providing attachment points for connective tissues or meninges?", "Does the image display bony features that support sensory or motor nerve pathways?", "Can you identify channels or sinuses that could participate in cerebrospinal fluid drainage?", "Is there a visible floor of the cranial cavity through which the brainstem passes to connect with the spinal cord?", "Does the image show a conduit for neural communication or vascular transmission between the brain and the rest of the body?"]}, "no_questions": {"contexual_properties": ["Is there evidence of hyperplasia, such as thickened or proliferative regions, possibly in response to chronic irritation, hormonal stimulation, or regeneration?", "Is there a visible superficial defect or erosion, possibly resulting from injury, chemical damage, or infection?", "Does any area appear unusually pale, suggesting anemia, ischemia, or reduced blood flow?"], "properties": ["Is there a tissue area that might contain a moderate amount of elastic fibers, contributing to flexibility and resilience?", "Does the image contain a region that looks soft, moist, and smooth in texture?", "Is there a tissue area that could have a density similar to 1.05 grams per cubic centimeter?"], "relational": ["Is there a layer that lies superficial to the submucosa and is separated from it by another thin muscle layer?", "Is there evidence of glands, capillaries, lymphatic vessels, or nerve endings supported by a tissue layer?", "Is there a structure present that might belong to the stomach, intestine, esophagus, nasal cavity, or bladder?"], "contexual_behavior": ["Is there a region where enzymatic activity might be diminished in the context of chronic inflammation or enzyme deficiency?", "Does the image contain a region that could enhance immune defense activity during antigen exposure or immune stimulation?", "Does the image show a tissue that fails to protect underlying layers when epithelial integrity is compromised or ulceration is present?"], "functions": ["Does the image suggest the presence of a tissue involved in local inflammatory responses, such as recruiting immune cells or releasing cytokines upon injury or infection?", "Does the image show a tissue that could contain sensory receptors or nerve endings for sensing environmental changes?", "Is there a visible layer where tight junctions between epithelial cells or a mucus layer might be present?"]}}, "right petrous bone": {"yes_questions": {"contexual_properties": ["Is there a region of the skull base that appears thickened, which could suggest conditions like fibrous dysplasia or Paget disease?", "Can you identify an area that appears thinned, possibly due to congenital anomalies or pressure from an adjacent mass?", "Is there evidence of abnormal bone density that might indicate a metabolic bone disease or osteolytic lesion?", "Does the image show any lesions that could be consistent with cholesteatoma, metastasis, or a primary bone tumor?", "Is there a sclerotic appearance in a part of the temporal bone that could be related to chronic inflammation or metastatic prostate cancer?", "Can you see any bone erosion that might be caused by cholesteatoma, malignancy, or chronic infection?", "Is there a region with increased porosity, as seen in osteoporosis or hyperparathyroidism?", "Do you observe any shape changes in the skull base that could be due to congenital malformation, trauma, or an expansive lesion?", "Is there evidence of bone deformation that might result from trauma, neoplastic invasion, or a developmental disorder?", "Can you identify abnormal calcification, such as might be seen with osteoma or a calcified meningioma?", "Is there a visible loss of bone mass that could be attributed to osteoporosis or neoplastic destruction?", "Does any area show abnormal imaging signal that could suggest infection, tumor, or bone marrow edema?", "Are there signs of fracture in the skull base that might be due to trauma, metastatic disease, or severe osteoporosis?", "Is there a region that appears hyperintense on MRI, possibly indicating bone marrow edema or acute infection?", "Do you see any hypointense areas on MRI that could be related to sclerotic lesions, fibrosis, or calcification?", "Is there abnormal enhancement after contrast administration, which might suggest tumor, infection, or a vascular malformation?", "Can you identify cystic changes that could be due to a petrous apex cephalocele, cholesterol granuloma, or a cystic tumor?", "Is there evidence of tumor infiltration from a primary bone malignancy, metastatic disease, or direct extension from an adjacent cancer?", "Do you observe increased vascularity that could be associated with a vascular tumor, arteriovenous malformation, or inflammation?", "Are there abnormal surface irregularities that might result from chronic infection, neoplastic invasion, or post-traumatic remodeling?"], "properties": ["Is there a structure in the image that measures approximately 3 to 4 centimeters in length and 1 to 2 centimeters in width?", "Can you identify an object with a pyramidal or wedge-like shape?", "Does the image show a bone with a dense, hard, and slightly rough surface texture?", "Is there a structure with a density around 1.8 to 2.0 grams per cubic centimeter?", "Can you see a bone that appears off-white to pale yellow in color?", "Is there an object whose thickness ranges from 4 to 8 millimeters?", "Does the image contain a structure with low porosity, typically less than 10%?", "Can you identify a bone that is primarily composed of hydroxyapatite, calcium, and phosphate?", "Is there a structure with a calcium concentration of approximately 35% by weight?", "Does the image show a bone with a phosphorus content of about 17% by weight?", "Can you see a structure with a collagen content of around 20% by weight?", "Is there an object with minimal fat content, generally less than 5% by weight?", "Does the image include a bone with negligible marrow content, mainly composed of dense cortical tissue?", "Can you identify a structure whose volume is around 3 to 6 cubic centimeters?", "Is there a bone with a Vickers hardness value between 50 and 70 HV?", "Does the image show a structure that contains cell types such as osteocytes, osteoblasts, and osteoclasts?", "Can you see an object with a water content of approximately 20% by weight?", "Is there a bone that weighs about 5 to 7 grams?"], "relational": ["Does the image show a structure that forms part of the cranial base?", "Is there an object that is a component of the skull and located on the right side?", "Can you identify a region adjacent to the occipital, sphenoid, or parietal bones?", "Does the image contain a structure associated with the posterior or middle cranial fossa?", "Is there a visible feature that contains openings such as the internal acoustic meatus, jugular foramen, or carotid canal?", "Can you see a pathway through which the facial nerve or vestibulocochlear nerve might pass?", "Does the image show a region related to the internal carotid artery or jugular vein?", "Is there a structure with distinct parts such as an apex or base, or features like the cochlear aqueduct?", "Can you identify an area that houses the cochlea, vestibular apparatus, or facial canal?", "Does the image include the petrous portion of the right temporal bone?", "Is there a structure that separates the middle ear from the inner ear or divides the middle and posterior cranial fossae?"], "contexual_behavior": ["Does the image show evidence of impaired protection for inner ear structures following trauma?", "Is there a visible fracture that could disrupt the continuity of the bony labyrinth and affect sound transmission?", "Can you identify signs of infection or inflammation that might cause bone edema or erosion and alter support for cranial nerves?", "Does the image reveal invasion or erosion by a skull base tumor that could compromise the shielding of the cochlea or vestibular apparatus?", "Is there any indication of bone erosion that exposes or compresses vascular channels such as the internal carotid artery or jugular vein?", "Can you see features suggesting decreased resistance to pressure changes, such as microfractures or demineralization, possibly due to barotrauma?", "Does the image display congenital malformations that might obstruct the vestibular or cochlear aqueducts and impair inner ear drainage?", "Are there signs of chronic otitis media with infection spreading to the petrous apex or causing bone demineralization that could alter protective function?", "Is there evidence of bone destruction or necrosis that would indicate loss of structural integrity due to osteomyelitis?", "Can you observe disruption of the ossicular chain or cochlear capsule that could affect the passage of sound, possibly resulting from a temporal bone fracture?"], "functions": ["Does the image show a region of the temporal bone that provides protection and structural support to critical sensory organs?", "Can you identify a dense bony enclosure that surrounds the cochlea and vestibular apparatus, shielding the inner ear from trauma?", "Is there a structure present that houses the organ responsible for converting sound vibrations into neural signals for hearing?", "Does the image contain a bony area that supports the organs involved in detecting head position and movement for balance?", "Can you see a region that provides canals for the passage of the vestibulocochlear nerve?", "Is there a structure that anchors the oval window and facilitates the transmission of sound from the middle ear to the cochlea?", "Does the image show a bony pathway that safeguards cranial nerves such as the facial nerve and vestibulocochlear nerve?", "Can you identify an area that encases and protects the internal carotid artery as it passes through the base of the skull?"]}, "no_questions": {"contexual_properties": ["Can you identify visual signs consistent with severe hepatic dysfunction?", "Does the image display features suggestive of advanced liver disease with possible complications affecting other organs?", "Does the image show evidence of a chronic liver condition associated with end-stage organ damage?"], "properties": ["Can you identify features consistent with end-stage damage to an organ involved in metabolism and detoxification, accompanied by signs of acute hemodynamic instability?", "Does the image show evidence of a chronic liver condition characterized by extensive scarring and nodular regeneration?", "Is there visual indication of a pathological process that could lead to impaired hepatic function and systemic circulatory collapse?"], "relational": ["Does the image display structural changes within the abdominal cavity, peritoneal space, or lower extremities?", "Is there evidence of fluid accumulation involving the peritoneum, portal capillaries, or lymphatic vessels?", "Can you identify structural alterations in organs such as the liver, spleen, or kidneys?"], "contexual_behavior": ["Does the image show evidence of an advanced liver condition characterized by widespread scarring and nodularity?", "Is there visual indication of a pathological process that could lead to impaired liver function and systemic circulatory failure?", "Can you identify features consistent with end-stage damage to an organ involved in metabolism and detoxification, accompanied by signs of hemodynamic instability?"], "functions": ["Is there a structure present that could indicate end-stage damage to a gland involved in metabolism?", "Can you identify visual signs consistent with severe dysfunction of an organ responsible for detoxification?", "Does the image reveal features suggestive of circulatory collapse or poor perfusion in association with chronic organ disease?"]}}, "petrous": {"yes_questions": {"contexual_properties": ["Is there a region of bone that appears thickened, which could suggest conditions like fibrous dysplasia or Paget\u2019s disease?", "Does the image show an area of increased bone density that might be seen in osteopetrosis or sclerotic metastases?", "Can you identify any bone that appears demineralized, as might occur in osteoporosis or chronic otitis media with bone erosion?", "Is there evidence of altered bone shape that could be due to congenital anomaly, trauma, or an expansive lesion such as cholesteatoma?", "Does the image reveal sclerotic changes in bone that might indicate chronic infection, osteosclerosis, or metastatic disease?", "Are there abnormal calcifications present that could be associated with labyrinthitis ossificans or certain tumors?", "Can you see any bone erosion that might result from cholesteatoma, chronic infection, or neoplastic invasion?", "Is there a region with reduced bone mass, possibly due to metabolic bone diseases like osteoporosis or hyperparathyroidism?", "Does any part of the bone appear enlarged, which could be a sign of fibrous dysplasia, Paget\u2019s disease, or a neoplastic process?", "Are there lytic lesions visible that could suggest multiple myeloma, metastasis, or Langerhans cell histiocytosis?", "Is there any area of bone that appears discolored on imaging, as might be seen with hemorrhage, infection, or neoplastic infiltration?", "Does the image show abnormal signal intensity on MRI in a region that could indicate inflammation, tumor, or vascular malformation?", "Can you identify porous bone that might be present in osteoporosis, chronic infection, or osteogenesis imperfecta?", "Is there evidence of loss of structural integrity in bone, possibly due to trauma, extensive infection, or malignant invasion?", "Are there signs of abnormal tissue infiltration that could be due to neoplastic spread, granulomatous disease, or leukemia?", "Does the image reveal compression of bone by an expanding mass such as a tumor, cyst, or vascular anomaly?", "Are there cystic changes present that might be consistent with cholesterol granuloma or a petrous apex cyst?", "Is there a region with increased vascularity, as might be seen in vascular tumors like paraganglioma or hemangioma?", "Can you see any fractures in the bone that could result from blunt head trauma or temporal bone injury?", "Is there evidence of abnormal bone remodeling that might be associated with chronic infection, Paget\u2019s disease, or prior surgical intervention?"], "properties": ["Is there a structure in the image that has a pyramidal or wedge-shaped form?", "Can you identify an object that appears pale yellowish-white in color?", "Does the image show a bone with a smooth and dense surface texture?", "Is there a structure that seems to be composed primarily of compact bone with minimal cancellous bone?", "Can you see an object that would likely measure about 30 to 40 millimeters in length?", "Is there a structure whose width could be estimated at 8 to 12 millimeters?", "Does the image contain a bone that might be 4 to 8 millimeters thick?", "Can you identify a structure that would be expected to weigh approximately 5 to 7 grams?", "Is there an object that would have a high mineral content, mainly hydroxyapatite with elevated calcium and phosphorus levels?", "Does the image show a bone with very low porosity, generally less than 5%?", "Is there a structure that would be expected to have a low water content, less than 10% by weight?", "Can you see an object that would likely have a high hardness, around 5 on the Mohs scale?", "Is there a structure that would be expected to have a density of about 2.0 to 2.2 grams per cubic centimeter?", "Does the image show a bone with a calcium concentration of approximately 350 to 400 milligrams per gram?", "Can you identify a structure with a phosphorus concentration of about 150 to 200 milligrams per gram?", "Is there an object whose temperature would match core body temperature, around 37 degrees Celsius?"], "relational": ["Does the image show a pyramid-shaped region within the temporal bone?", "Is there a structure visible at the cranial base that could be part of the temporal bone?", "Can you identify an area adjacent to the middle cranial fossa?", "Does the image contain a region near the internal acoustic meatus or jugular foramen?", "Is there evidence of foramina such as the internal acoustic meatus or carotid canal?", "Can you see any anatomical features associated with the passage of the facial, vestibulocochlear, or trigeminal nerves?", "Is there a structure in the image that could be traversed by the internal carotid artery or related to the superior petrosal sinus or jugular vein?", "Does the image show cavities or spaces like the inner ear cavity or mastoid air cells?", "Can you identify inner ear structures such as the cochlea, vestibule, or semicircular canals within a bony region?", "Is there a location where ligaments or membranes like the petrosphenoidal ligament or tentorium cerebelli might attach?"], "contexual_behavior": ["Does the image show a region where inner ear structures might be less protected in the presence of bone erosion or congenital malformation?", "Can you identify an area whose ability to transmit sound vibrations could be impaired by trauma or neoplastic invasion?", "Is there evidence of a structure that might allow infection to spread from adjacent tissues, such as in osteomyelitis or after surgery?", "Does the image reveal a region that fails to shield the cochlea and vestibular apparatus during basilar skull fractures?", "Can you see an area where support for cranial nerve passage may be altered due to inflammation or stenosis?", "Is there a structure whose barrier function against intracranial pressure changes could be compromised by bone thinning or invasive infection?", "Does the image include a region where vascular protection might be impaired during petrositis or osteomyelitis?", "Can you identify an area where sound conduction could be disrupted after a fracture involving the ossicular chain?", "Is there a visible region where separation between middle and inner ear spaces might be altered due to congenital anomalies or abnormal ossification?", "Does the image show a structure that could lose effectiveness in dampening mechanical forces during a comminuted fracture?", "Is there an area where support for the internal auditory canal may be compromised by tumor growth such as vestibular schwannoma?", "Can you see a region where anchoring of the dura mater might be affected by chronic infection or bone destruction?", "Does the image reveal a structure whose protective role for the facial nerve could decrease due to bone resorption from osteomyelitis?", "Is there evidence of impaired cranial base stability in a region affected by osteoporosis or bone weakening?", "Can you identify an area where chronic otitis media may have caused bone erosion, sclerosis, or inflammatory changes?"], "functions": ["Does the image show a dense bony structure that encases delicate components of the inner ear?", "Can you identify a region that provides attachment points for muscles or ligaments near the base of the skull?", "Is there a bony enclosure visible that shields the cochlea and vestibular apparatus from potential injury?", "Does the image contain a structure that houses the organ responsible for converting sound waves into neural signals?", "Can you see a region that contains the apparatus responsible for detecting head position and maintaining balance?", "Is there a rigid bony area that supports the cochlea and facilitates the transmission of sound vibrations?", "Does the image include a foramen, such as the internal acoustic meatus, that allows passage of cranial nerves VII and VIII?", "Can you identify a structure that provides protection for neurovascular elements like the facial nerve, vestibulocochlear nerve, or internal carotid artery?", "Is there evidence of a bony barrier that reduces the risk of external trauma to the inner ear?", "Does the image show a labyrinthine bony region that houses both auditory and vestibular apparatus, such as the cochlea and semicircular canals?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a cavity adjacent to the nasal cavity, orbit, or upper teeth roots?", "Is there a space that connects to the nasal cavity through an opening in the middle meatus?", "Does the image show a structure that is part of the respiratory system and is surrounded by the maxilla?"], "contexual_behavior": [], "functions": ["Is there a cavity present that could amplify or modify sound vibrations during speech?", "Can you identify a structure that contributes to humidifying and warming inhaled air by providing a moist mucosal surface?", "Does the image contain a space lined with mucosa that produces mucus and facilitates its drainage into the nasal cavity?"]}}, "petrous bone": {"yes_questions": {"contexual_properties": ["Does the image show a thickened region of bone that could be associated with chronic otitis media or Paget's disease?", "Is there evidence of sclerosis in a structure that might result from chronic inflammation, osteopetrosis, or otosclerosis?", "Can you identify an area of decreased bone density that could suggest osteolytic lesions, metastases, or osteoporosis?", "Is there a region of bone erosion that might be due to cholesteatoma, malignancy, or chronic infection?", "Does the image reveal abnormal calcification that could be linked to osteosclerosis, fibrous dysplasia, or prior trauma?", "Can you see any lesions that may indicate the presence of tumors, cysts, or infectious processes?", "Is there a deformed bony structure that could be the result of congenital anomalies, trauma, or advanced bone disease?", "Does the image show increased porosity in a bone that might be associated with osteoporosis or hyperparathyroidism?", "Is there a region of bone discoloration that could be caused by hemorrhage, infection, or neoplastic infiltration?", "Can you identify an enlarged bony area that might be related to Paget's disease, fibrous dysplasia, or neoplastic growth?", "Is there evidence of bone thinning that could be due to chronic pressure erosion, congenital hypoplasia, or osteolytic processes?", "Does the image display abnormal MRI signal in a region that could be affected by edema, tumor, or infection?", "Can you see cystic changes that might result from congenital cysts, cholesterol granuloma, or neoplastic degeneration?", "Is there a loss of structural integrity in a bone that could be attributed to severe infection, malignancy, or extensive trauma?", "Does the image show abnormal vascularity in a bony region that might be due to vascular malformations, tumors, or inflammation?", "Can you identify fluid accumulation that could suggest petrous apicitis, cyst formation, or abscess development?", "Is there evidence of bone marrow changes that might be caused by marrow infiltration, infection, or hematologic disorders?", "Does the image reveal bone fragmentation that could result from severe trauma, osteomyelitis, or neoplastic destruction?", "Is there a region with abnormal mineral content that might indicate metabolic bone diseases such as osteomalacia or hyperparathyroidism?", "Can you see signs of infection in a bony area that could be related to petrous apicitis, osteomyelitis, or chronic mastoiditis?"], "properties": ["Is there a structure in the image with a pyramidal or wedge-like shape?", "Can you identify an object located obliquely at the base of the skull between the sphenoid and occipital bones?", "Does the image show a bone with a pale ivory to light yellow appearance?", "Is there a structure whose size appears to be approximately 2 to 3 centimeters in length and 1 to 2 centimeters in width?", "Can you see a bone that might have a thickness between 4 and 8 millimeters?", "Does the image contain a structure with a smooth and compact surface texture?", "Is there an object that could have a low porosity, generally less than 5 percent?", "Can you identify a bone that is likely to have high density, around 2.0 to 2.2 grams per cubic centimeter?", "Does the image show a structure that could weigh about 2 to 4 grams?", "Is there a bone present with an estimated volume of 2 to 4 cubic centimeters?", "Can you see a structure that contains cell types such as osteocytes, osteoblasts, and osteoclasts?", "Is there an object that might have a mineral composition primarily of hydroxyapatite, containing calcium and phosphate?", "Does the image include a bone with a water content of approximately 10 to 20 percent by weight?", "Can you identify a structure with a Vickers hardness value of about 60 to 70 HV?", "Is there a bone that could have a calcium concentration of roughly 20 to 25 percent by weight?", "Does the image show a structure with a phosphorus concentration of about 10 to 12 percent by weight?", "Can you see an object whose organic matrix content is approximately 20 to 25 percent by weight?", "Is there a bone present with collagen making up about 90 percent of its organic matrix, mainly type I collagen?"], "relational": ["Does the image show a dense, pyramid-shaped region within the temporal bone?", "Can you identify a structure located at the base of the skull in the cranial region?", "Is there a part of the skull that forms the petrous portion of the temporal bone?", "Does the image include anatomical features such as the internal acoustic meatus, jugular fossa, or carotid canal?", "Can you see foramina like the internal acoustic meatus or carotid canal within the temporal bone?", "Is there a region that houses inner ear structures such as the cochlea, vestibule, or semicircular canals?", "Does the image show the passage or proximity of cranial nerves such as the facial, vestibulocochlear, or trigeminal nerves?", "Can you identify blood vessels like the internal carotid artery or the superior petrosal sinus associated with a bony region?", "Is there a cavity or space resembling the bony labyrinth or internal acoustic meatus present?", "Does the image show attachments for membranes or ligaments such as the tentorium cerebelli or the petro-sphenoidal ligament?"], "contexual_behavior": ["Does the image show evidence of impaired protection of inner ear structures, such as might be seen in the presence of a temporal bone fracture or osteolytic lesion?", "Is there a structure whose ability to transmit sound vibrations appears reduced, possibly due to sclerosis, fracture, or signs of chronic ear infection?", "Can you identify features suggesting inflammation, bone erosion, or cholesteatoma formation that could alter the function of a bone involved in chronic ear infections?", "Does the image reveal exposure of the cochlea or vestibular apparatus that might result from bone fracture or erosion?", "Is there any indication that the support for cranial nerves is compromised, such as by tumors, infections, or demyelinating lesions near the temporal region?", "Can you see disruption of the bony labyrinth that could affect the housing of auditory and vestibular organs, as might occur after a fracture?", "Does the image suggest a breach between intracranial and extracranial compartments, possibly due to a skull base fracture or congenital defect?", "Are there signs that increased intracranial pressure is being transmitted to adjacent neurovascular structures, indicating altered protective behavior of a dense cranial bone?", "Is there visual evidence of reduced bone density or structural weakening that could affect ligament and muscle attachment, as seen in osteoporosis?", "Can you detect changes in venous drainage patterns, such as might occur with thrombosis of the petrosal sinuses or adjacent veins?", "Does the image show age-related changes like bone sclerosis or degeneration that could contribute to a decline in hearing transmission?", "Is there evidence of bone erosion or dehiscence that might allow infection to spread to the inner ear from chronic infection?", "Can you identify any compromise of the facial nerve's structural support, possibly due to tumors such as schwannomas or cholesteatomas?", "Does the image reveal alterations in sound conduction pathways that could result from surgical interventions like mastoidectomy or cochlear implantation?", "Is there any indication that the internal carotid artery is less protected, such as after trauma causing fracture or injury to the carotid canal?"], "functions": ["Is there a dense bony structure in the image that provides protection and structural support to delicate inner ear components?", "Can you identify a region that forms an enclosure around the cochlea and vestibular apparatus, shielding them from mechanical injury?", "Does the image show a structure that houses the cochlea, enabling the transmission of sound vibrations to auditory receptors?", "Is there an area that contains the vestibular apparatus and provides a stable environment necessary for balance and equilibrium?", "Can you see a structure that anchors the oval window and facilitates the transmission of sound vibrations from the middle ear to the cochlea?", "Does the image include a region that encases the internal auditory canal, thereby protecting the auditory and vestibular nerves?", "Is there a visible bony canal that safeguards the facial nerve as it passes through the temporal bone?", "Can you identify a barrier that separates the middle ear from the inner ear, helping to prevent the spread of infection and maintain compartmentalization?", "Is there a structure acting as a buffer between the inner ear and the posterior cranial fossa, contributing to brainstem protection at the cranial base?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure composed of glandular tissue and fibromuscular stroma?", "Is there a structure whose lymphatic drainage could involve the internal iliac or obturator lymph nodes?", "Does the image contain a region with connective tissue in the pelvic area?"], "contexual_behavior": ["Is there a structure that may fail to regulate seminal pH under physiological or psychological stress?", "Is there a structure that reduces its functional capacity after surgical intervention, such as removal or resection?", "Is there an anatomical entity whose function could be impaired by hormonal imbalance, particularly with decreased androgen levels?"], "functions": ["Can you identify an organ that adds enzymes and nutrients to semen to support sperm motility and viability?", "Does the image show an organ that regulates seminal fluid composition by releasing substances such as zinc and citric acid?", "Can you identify an organ that responds to androgens and influences local hormone activity?"]}}, "brain removed": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears lighter in weight or mass compared to its typical in situ state, possibly due to dehydration or tissue mass reduction?", "Is there evidence of color changes in a tissue that could result from oxidation or hemoglobin breakdown over time?", "Can you observe a structure that appears softer or more fragile, potentially due to autolysis or enzymatic degradation?", "Does the image display a tissue that seems to have lost moisture, showing signs of evaporation or desiccation?", "Is there a structure that appears shrunken, possibly as a result of fluid loss or tissue contraction?", "Can you identify surface discoloration on a tissue that might be caused by blood pooling or microbial activity?", "Does the image reveal tissue breakdown or loss of structural integrity, suggesting autolytic or putrefactive processes?", "Is there a structure that looks more fragile, perhaps due to connective tissue degradation or decreased cellular cohesion?", "Can you see abnormal texture in a tissue, which could be attributed to enzymatic digestion or microbial invasion?", "Does the image show a loss of structural integrity in a tissue, possibly from cellular or matrix component breakdown?", "Is there evidence of increased decomposition in a structure, indicated by bacterial or enzymatic activity?", "Can you observe fluid accumulation in a tissue, potentially resulting from autolysis or vascular barrier breakdown?", "Does the image show cavities or hollow areas within a tissue, which might be due to liquefaction or tissue necrosis?", "Is there a structure that appears lighter, possibly as a result of water loss or reduction in tissue mass?", "Can you detect changes in density or composition of a tissue, which could be explained by fluid loss or tissue degradation?"], "properties": ["Is there an object in the image with an irregularly ovoid shape and prominent convolutions?", "Can you identify a structure that appears pale gray with some pinkish or off-white areas?", "Does the image show something with a soft, gelatinous texture that looks easily deformable?", "Is there a structure whose size could be approximately 15 centimeters in length, 13 centimeters in width, and 9 centimeters in height?", "Can you see an object that might weigh between 1200 and 1400 grams?", "Is there a structure with a glossy surface and clear separation into two hemispheres?", "Does the image contain an object with visible gyri and sulci, possibly dozens per hemisphere?", "Can you identify a structure whose estimated surface area could be between 2000 and 2500 square centimeters?", "Is there an object that could have a volume in the range of 1200 to 1500 milliliters?", "Does the image show a structure that is likely to have a water content of about 75 to 80 percent by weight?", "Can you see an object that might have a density close to 1.03 grams per cubic centimeter?", "Is there a structure that could contain neurons, astrocytes, oligodendrocytes, microglia, and endothelial cells?", "Does the image include an object that might have a lipid content of 10 to 12 percent of its wet weight?", "Can you identify a structure that could have a protein content of approximately 8 to 10 percent of its wet weight?", "Is there an object that might have a cholesterol level of 2 to 3 percent of its dry weight?", "Does the image show a structure that could contain about 50 to 60 milligrams of iron per kilogram of tissue?", "Can you see an object whose pH might be slightly acidic, around 6.8 to 7.0?", "Is there a structure that would rapidly approach room temperature after removal?", "Does the image show an object whose composition includes water, lipids, proteins, carbohydrates, and minerals?", "Can you identify a structure in which the glucose concentration would be less than 1 mmol/L postmortem?"], "relational": ["Does the image show the absence of a component of the nervous system within the cranial cavity?", "Is there a visible space where the cerebrum, cerebellum, or brainstem would normally be located?", "Can you observe the medulla oblongata exposed or disconnected from its usual connection?", "Are the protective membranes such as the dura mater, arachnoid mater, or pia mater visible without the underlying tissue they typically cover?", "Does the image reveal blood vessels like the internal carotid or vertebral arteries without their usual destination?", "Are the lateral, third, or fourth ventricles exposed or empty in the cranial cavity?", "Can you see cranial nerves such as the olfactory, optic, or trigeminal nerves without their typical origin?", "Are the bones of the cranium, such as the frontal, parietal, or occipital bones, visible without the structure they usually encase?", "Is the pia mater or cerebral cortex absent or missing from its normal location?", "Are adjacent structures like the pituitary gland, cranial nerves, or cerebrospinal fluid spaces more exposed than usual?"], "contexual_behavior": ["Does the image show a specimen where regulation of vital autonomic functions such as heart rate and respiration would be immediately impaired?", "Is there evidence that voluntary movement coordination is no longer possible in the subject depicted?", "Can you determine if hormonal regulation via the hypothalamic-pituitary axis is absent in this specimen?", "Does the image suggest that sensory perception and processing are no longer possible?", "Is there an indication that normal sleep-wake cycles and circadian rhythm regulation are disrupted?", "Can you infer that cognitive integration and higher mental processes are no longer present?", "Does the specimen lack the capacity for reflexive responses mediated by higher centers?", "Is there evidence that physiological homeostasis cannot be maintained in the depicted subject?", "Can you see signs that cardiovascular regulation via central autonomic input is disrupted?", "Does the image suggest that adaptive behavioral responses to environmental changes are no longer possible?", "Is there an absence of central control over respiratory rhythm in the specimen?", "Can you infer that thermoregulation mechanisms, particularly those involving the hypothalamus, are disrupted?", "Does the subject lack the ability to modulate immune system function through neuroimmune interactions?", "Is there evidence that central processing of pain signals (nociception) is abolished?", "Can you determine if learning and memory formation are no longer possible in this specimen?", "Does the image suggest that emotional responses mediated by the limbic system are absent?", "Is there impairment in the coordination of swallowing and speech in the depicted subject?", "Can you infer that endocrine feedback loops regulated by the hypothalamus and pituitary are disrupted?", "Does the specimen lack the ability to adapt to stress due to loss of central regulatory mechanisms?", "Is there evidence that initiation of movement is no longer possible in the subject shown?"], "functions": ["Does the image show an organism lacking the ability to perform voluntary movements?", "Is there evidence that sensory perception or processing is absent in the depicted subject?", "Can you identify a body where central regulation of homeostasis and autonomic functions is disrupted?", "Does the image suggest that respiration and heartbeat regulation have ceased?", "Is there an absence of neural signaling or motor control observable in the specimen?", "Can you see signs that hormone secretion or endocrine system regulation is no longer centrally controlled?", "Does the subject appear incapable of automatic regulation of breathing or heart rate?", "Is there any indication that the ability to respond to external stimuli or perform reflex actions is lost?", "Can you infer from the image that consciousness and awareness are entirely absent?", "Does the depicted organism show failure of coordination among organ systems due to loss of integrative neural control?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a cell with abundant, pale, and slightly basophilic cytoplasm visible?", "Is there a cell in the image that measures between 20 and 50 micrometers in diameter?", "Can you identify a cell with pale pink cytoplasm and dark purple nuclei under light microscopy?"], "relational": ["Can you identify a structure that is related to mononuclear Hodgkin cells or lacunar cells?", "Does the image show a lesion within lymphoid tissue that is characteristic of Hodgkin lymphoma?", "Does the image display a tumor mass or cellular infiltrate typical of Hodgkin lymphoma?"], "contexual_behavior": [], "functions": ["Is there a structure that could be evading immune detection, possibly by expressing immune checkpoint molecules or reducing antigen presentation?", "Is there visual evidence of cytokine or chemokine signaling activity, such as clustering of immune cells around atypical cells?", "Can you identify cells that might be suppressing immune responses or recruiting inflammatory cells in their vicinity?"]}}, "gastrointestinal": {"yes_questions": {"contexual_properties": ["Is there evidence of inflammation in a tubular structure that could suggest gastroenteritis or inflammatory bowel disease?", "Can you see a thickened wall in any segment that might indicate Crohn's disease or neoplasia?", "Is there a visible narrowing of a passage that could be due to a stricture or tumor?", "Do you observe any ulcerations that might be associated with peptic ulcer disease or NSAID use?", "Is there an area with increased mucus that could suggest infection or an allergic reaction?", "Can you identify a dilated segment that might be consistent with obstruction or megacolon?", "Do you see any changes in the color of the lining that could indicate ischemia or jaundice?", "Are there any polyp-like growths that could be related to familial adenomatous polyposis or colorectal cancer risk?", "Is there swelling or edema visible in the wall that might be due to acute inflammation or ischemic injury?", "Do you observe signs that could indicate increased permeability, such as mucosal irregularity in the context of celiac disease or infection?", "Is there a loss of normal folds in a segment that could suggest atrophic gastritis or malabsorption?", "Can you see evidence of a stricture that might have developed after surgery or radiation therapy?", "Are there abnormal motility patterns, such as stasis or distension, that could indicate gastroparesis or intestinal obstruction?", "Is there an accumulation of gas within a segment that might be due to bacterial overgrowth or malabsorption?", "Do you notice areas where the wall appears thinner, possibly due to atrophy or chronic malnutrition?", "Is there visible bleeding or evidence of hemorrhage that could be related to peptic ulcers or malignancy?", "Can you see increased cellular infiltration, such as thickened mucosa or whitish patches, that might suggest infection or chronic inflammatory disorders?", "Are there abnormal tissue growths, such as masses or nodules, that could indicate neoplasia or granulomatous disease?", "Do you observe any features that might suggest a change in pH, such as erosions or discoloration, possibly due to acid secretion disorders?", "Is there a segment that appears obstructed, with upstream dilation or impacted material, that could be caused by a tumor or stricture?"], "properties": [], "relational": ["Does the image contain any structure that is part of the digestive system?", "Can you identify organs such as the esophagus, stomach, small intestine, or large intestine?", "Is there a visible region corresponding to the oral cavity or pharynx?", "Does the image show any connecting structures like sphincters, mesentery, or ducts?", "Can you see glands such as salivary glands, gastric glands, or intestinal glands?", "Is there evidence of mucosal layers, such as epithelium, lamina propria, or muscularis mucosae?", "Are there major blood vessels present, such as the celiac artery, superior mesenteric artery, or inferior mesenteric artery?", "Does the image show any nerves or neural structures like the vagus nerve or enteric nervous system?", "Can you identify lymphatic features such as Peyer's patches, mesenteric lymph nodes, or lacteals?", "Are there organs adjacent to the digestive tract, such as the liver, pancreas, spleen, or gallbladder, visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show any structure involved in digestion or absorption of nutrients?", "Can you identify an area where mechanical breakdown or enzymatic hydrolysis of food might occur?", "Is there evidence of peristalsis or coordinated motility in any visible tissue?", "Does the image include regions where nutrient absorption is likely to take place, such as the small or large intestine?", "Can you see a structure that could be responsible for water absorption or electrolyte transport?", "Is there a visible pathway or opening through which waste could be expelled from the body?", "Does the image show features that might protect against pathogens, such as a mucosal barrier or lymphoid tissue?", "Can you identify any tissue that could secrete hormones like gastrin or secretin to regulate digestive processes?", "Is there evidence of immune defense mechanisms, such as mucosal immunity or clusters of lymphoid tissue?", "Does the image contain smooth muscle layers or networks that could coordinate motility via the enteric nervous system?", "Can you see any structures that might help maintain a balanced microbial environment, such as a mucosal surface?", "Is there a region where neutralization of stomach acid could occur, possibly involving bicarbonate secretion or specialized glands?", "Does the image show any features that could be involved in regulating appetite or satiety through hormonal or neural signals?"]}, "no_questions": {"contexual_properties": ["Does the image display an accumulation of exudate that might indicate active infection and ongoing exudation?", "Can you identify areas where the exudate looks more fibrinous, suggesting fibrinogen leakage and fibrin formation?", "Can you observe changes in the exudate that might reflect alterations in pH due to metabolic activity of immune cells or bacteria?"], "properties": ["Does the image show a viscous or caseous material?", "Can you see a sample with high fibrin content, potentially showing signs of clot formation?", "Does the image show a fluid that might have elevated lactate dehydrogenase (LDH) levels?"], "relational": ["Is there a region showing caseous necrosis or tissue destruction associated with an exudative process?", "Are there larger pathological structures such as caseating nodules or tuberculous granulomas present?", "Does the image contain structures located in the lungs, lymph nodes, or serous membranes that appear abnormal?"], "contexual_behavior": ["Can you identify a region with increased protein content, which might suggest active infection and inflammation?", "Can you see increased fibrin deposition, which could be a sign of chronic disease and persistent inflammation?", "Is there a visible decrease in defensive function, possibly related to malnutrition or immune deficiency?"], "functions": ["Does the image display features suggesting the aggregation of immune cells to form a matrix that walls off bacteria?", "Does the image show signs of chemotactic activity, such as the recruitment of macrophages, neutrophils, or lymphocytes to a specific area?", "Can you see features that suggest the infection is being contained locally, or alternatively, signs that liquefaction may be facilitating dissemination through airways or lymphatics?"]}}, "base of skull": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a region formed by bones such as the occipital, sphenoid, temporal, ethmoid, or frontal bones?", "Can you identify areas corresponding to the anterior, middle, or posterior cranial fossae?", "Is there evidence of large openings like the foramen magnum or smaller foramina such as the jugular foramen, foramen ovale, or hypoglossal canal?", "Does the image depict pathways for cranial nerves or major blood vessels?", "Can you see structures that support the frontal lobes, temporal lobes, cerebellum, or brainstem?", "Is there a visible floor of the cranial cavity that separates the brain from other regions?", "Does the image suggest the presence of nerves such as the olfactory, optic, or trigeminal nerves traversing through bony openings?", "Can you identify blood vessels like the internal carotid artery, vertebral artery, jugular vein, or basilar artery in relation to bony structures?", "Is there a region adjacent to the neck, nasal cavity, oral cavity, pharynx, or vertebral column?", "Does the image show attachment points for membranes such as the dura mater, arachnoid mater, or pia mater?"], "contexual_behavior": ["Does the image show evidence of a region where neural structures might be at increased risk of injury following trauma?", "Is there a visible area where a fracture could potentially disrupt the function of cranial nerves passing through foramina?", "Can you identify any features that might suggest impaired cerebrospinal fluid drainage due to obstruction or herniation?", "Does the image reveal any defects that could allow pathogens to enter the cranial cavity from the paranasal sinuses or middle ear?", "Is there a region where tumor invasion could encase or compress major blood vessels, potentially affecting vascular flow?", "Can you see any signs of disrupted bone integrity that would reduce the ability to absorb shock from high-impact injury?", "Does the image display any anatomical variations or malformations that might compromise structural support and lead to instability?", "Are there features suggesting narrowed sinus ostia or drainage pathways that could impair normal sinus drainage?", "Can you identify any pathways by which infection from the middle ear could extend to the petrous part of the temporal bone or inner ear structures, potentially affecting hearing?", "Is there evidence of unsealed dural or bony defects that could result in cerebrospinal fluid leakage after surgical intervention?"], "functions": ["Is there a structure in the image that provides a rigid platform supporting the brain?", "Can you identify an area that acts as a barrier separating the cranial cavity from facial or neck regions?", "Does the image show any features that serve as passageways for cranial nerves or blood vessels between the brain and peripheral areas?", "Is there a region that contains foramina or canals for nerve and vascular conduits?", "Can you see any attachment points for muscles involved in chewing or swallowing?", "Does the image include a structure that encases and protects cranial nerves as they exit or enter the cranial cavity?", "Is there evidence of a region contributing to the overall stability and shape of the head by connecting cranial bones?", "Can you identify an area involved in transmitting sound vibrations through the temporal bone to the inner ear?"]}, "no_questions": {"contexual_properties": ["Is there a visible lesion that might suggest the spread of malignant cells to a new location?", "Is there a structure that could represent a secondary growth from a primary tumor elsewhere in the body?", "Does the image contain a lesion with a solid, flesh-like appearance?"], "properties": [], "relational": ["Does the lesion appear to be associated with capillaries, arterioles, or venules?", "Is there a region that might contain malignant epithelial cells, stromal cells, or inflammatory cells?", "Does the lesion appear to be supported by fibrous stroma, extracellular matrix, or collagen fibers?"], "contexual_behavior": [], "functions": ["Is there a region that might show increased glucose uptake or altered metabolic activity, such as hypoxic areas within a mass?", "Is there evidence of a lesion causing disruption or compression of surrounding healthy cells?", "Is there visual evidence of local inflammation or tissue disruption near a tumor-like structure?"]}}, "lesion": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an area in the image that varies in size from a few millimeters to several centimeters?", "Can you identify a region with a round, oval, irregular, or linear shape?", "Does the image show any area with colors such as red, brown, black, white, or skin-colored?", "Is there a structure with a smooth, rough, scaly, or verrucous texture visible?", "Can you see a region with well-defined or ill-defined borders?", "Is there an area that appears superficial, partial-thickness, or full-thickness in depth?", "Does the image contain a region that looks soft, firm, hard, or fluctuant?", "Can you identify a surface that is flat, raised, depressed, or ulcerated?", "Is there a region whose volume appears variable based on its size and depth?", "Does any area seem to have increased temperature, possibly indicating inflammation or infection?", "Can you see a region that appears dry, moist, or exudative?", "Is there a structure that looks soft or hard, suggesting differences in firmness?", "Can you identify an area where the tissue appears to have decreased, normal, or increased elasticity?", "Does the image show a region that could be composed of cells, fluid, necrotic tissue, or fibrous material?", "Is there an area with low, intermediate, or high density as might be seen on imaging or by palpation?", "Can you see a region with uniform, variegated, or absent pigmentation patterns?", "Is there a surface that appears non-ulcerated or ulcerated?", "Does any area show signs of low, moderate, or high vascularity, such as increased redness or bleeding tendency?", "Can you identify a region with absent, scant, moderate, or copious exudate?", "Is there an area that appears to be growing slowly, moderately, or rapidly compared to surrounding tissue?"], "relational": ["Is there an area within the image where the structure of epithelial, connective, muscle, or nervous tissue appears altered?", "Can you identify a region in the skin, liver, brain, lung, or kidney that looks abnormal compared to the surrounding tissue?", "Does the image show any abnormality in regions such as the oral cavity, gastrointestinal tract, central nervous system, or skin?", "Is there a localized area that is surrounded by parenchyma, stroma, blood vessels, or a basement membrane?", "Can you see a region containing cells that resemble inflammatory, neoplastic, fibroblastic, or necrotic cell types?", "Does the image reveal a disruption in the structure or function of the nervous, respiratory, digestive, or integumentary system?", "Is there evidence of tissue disruption, infiltration, or inflammation in any part of the image?", "Can you identify a region with distinct margins, a capsule, or a clear interface with normal tissue?", "Does the image contain a structure that could be related to a tumor, ulcer, scar, or abscess?", "Is there an area involving specific tissue layers such as the epidermis, dermis, submucosa, muscularis, or subcutaneous tissue?"], "contexual_behavior": ["Is there a structure in the image that might heal more slowly if immune function is impaired?", "Can you identify an area that could increase in size during chronic inflammation?", "Does the image show a region where normal tissue regeneration might fail if fibrosis predominates?", "Is there a feature that could exhibit reduced repair activity in the context of diabetes mellitus?", "Can you see an area that might be more prone to infection in an immunocompromised state?", "Does the image contain a region that could demonstrate accelerated healing after therapeutic intervention?", "Is there a structure that might show impaired vascularization in a hypoxic environment?", "Can you identify an area that could persist due to ongoing exposure to toxins?", "Does the image show a region where increased scarring might occur during abnormal wound healing?", "Is there a feature that could fail to resolve in the presence of autoimmune disease?", "Can you see an area that might become more active following acute trauma?", "Does the image contain a region that could demonstrate decreased cellular turnover in aging tissue?", "Is there a structure that might exhibit delayed closure under malnutrition?", "Can you identify an area that could show increased inflammatory response during infection?", "Does the image show a region that might fail to repair due to poor blood supply?"], "functions": ["Does the image show an area of abnormal tissue change or damage?", "Is there a region where normal tissue architecture appears disrupted?", "Can you identify a structure that might impair the function of the surrounding tissue?", "Is there evidence of altered cell proliferation or increased cell death in a specific area?", "Does the image reveal signs of local inflammation, such as immune cell infiltration?", "Can you see a region that could be activating local immune responses?", "Is there an area where tissue repair or regeneration might be occurring, such as the presence of healing cells?", "Does the image show features suggesting the release of cytokines or growth factors in a localized region?", "Is there a visible abnormality that could compromise the function of an organ or tissue?", "Can you identify a region that might be contributing to chronic inflammation or disease progression?", "Is there evidence of vascular or lymphatic obstruction, such as localized swelling or impaired drainage?", "Does the image show an area that could be causing pain or altered sensation by affecting nerve endings?", "Can you see signs of protective responses like clot formation or increased immune activity in a specific region?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a structure composed mainly of trophoblast cells, such as cytotrophoblasts or syncytiotrophoblasts?", "Can you identify a tissue with a high water content, around 70 to 80 percent by weight?", "Can you see a tissue that appears pale eosinophilic to pinkish under the microscope?"], "relational": ["Does the image show a layer located within the chorionic membrane or the fetal portion of the placenta?", "Is there a structure interacting with maternal tissues like the decidua basalis of the endometrium?", "Can you identify a boundary between the amniotic membrane and the extraembryonic mesoderm?"], "contexual_behavior": [], "functions": ["Is there a visible interface where oxygen diffusion to the fetus and removal of carbon dioxide to the mother could occur?", "Does the image include a component that facilitates the transfer of fetal metabolic waste products into the maternal circulation?", "Does the image show a region involved in promoting adhesion and invasion during the establishment of the maternal-fetal interface at implantation?"]}}, "surface right bone": {"yes_questions": {"contexual_properties": ["Is there a structure on the right side of the image that appears roughened, possibly indicating osteoarthritis or chronic inflammation?", "Can you identify a right-sided structure with increased porosity, as might be seen in metabolic bone diseases such as osteoporosis?", "Does the image show erosion on a right-sided structure, which could suggest rheumatoid arthritis or infection?", "Is there evidence of abnormal growths, such as osteophytes or exostoses, on a right-sided bony surface?", "Can you see thickening of a right-sided structure that might indicate osteosclerosis or Paget\u2019s disease?", "Is there a right-sided structure that appears thinned, as might occur in osteoporosis or after prolonged disuse?", "Does the image reveal any color changes on a right-sided structure, such as those caused by bruising or pigment deposition?", "Is there a sclerotic appearance on a right-sided structure, possibly due to chronic inflammation or metastasis?", "Can you observe pits or depressions on a right-sided structure, as seen in bone resorption disorders or osteitis fibrosa cystica?", "Does a right-sided structure appear smoother than expected, which could result from surgical intervention or bone remodeling?", "Is there evidence of mineral deposits on a right-sided structure, as might be found in osteopetrosis or chronic kidney disease?", "Can you see signs of inflammation, such as swelling or redness, on a right-sided structure that could indicate osteomyelitis or periostitis?", "Is there a loss of density in a right-sided structure, as might be seen in osteomalacia or after prolonged immobilization?", "Does a right-sided structure appear irregular, potentially due to fracture healing or chronic infection?", "Can you identify cracks or fissures on a right-sided structure, as might occur in stress fractures or trauma?", "Is there an increase in vascular markings on a right-sided structure, possibly related to hyperemia or bone infection?", "Does a right-sided structure appear brittle, which could be a sign of osteogenesis imperfecta or chronic corticosteroid therapy?", "Can you observe cystic changes on a right-sided structure, such as those seen in unicameral or aneurysmal bone cysts?", "Is there a hyperdense area on a right-sided structure, as might be seen in osteosclerosis or metastatic prostate cancer?", "Does the image show lytic lesions on a right-sided structure, which could indicate multiple myeloma or metastatic cancer?"], "properties": ["Is there a structure on the right side of the skeleton that appears curved and elongated?", "Can you identify an object with an off-white to pale yellow color on the right side of the body?", "Does the image show a structure whose thickness could be estimated between 1.5 and 4 millimeters?", "Is there an elongated structure with a width likely between 2 and 5 centimeters?", "Can you see a right-sided skeletal element that might have a surface area between 100 and 300 square centimeters?", "Is there a structure whose length could fall within the range of 10 to 30 centimeters?", "Does the image contain a dense, smooth-surfaced object on the right side of the skeleton?", "Can you identify a structure that is likely to have a low fat content, less than 5 percent by weight?", "Is there a right-sided skeletal element that could contain cells such as osteocytes, osteoblasts, or osteoclasts?", "Does the image show a structure whose mineral composition is mainly hydroxyapatite with calcium and phosphate?", "Can you see an object that might have a water content of about 10 to 20 percent by weight?", "Is there a structure that could have a collagen content of approximately 20 to 30 percent by weight?", "Can you identify a right-sided skeletal element that would be expected to have a hardness of 3 to 4 on the Mohs scale?", "Does the image show a structure with a porosity likely between 5 and 10 percent?", "Is there a right-sided bone that could have a magnesium concentration of about 1 to 2 milligrams per gram?", "Can you see a structure whose elastic modulus might be in the range of 17 to 20 gigapascals?", "Does the image contain a right-sided skeletal structure with a microstructure that includes organized osteons and Haversian systems?", "Is there a structure that could have a calcium concentration between 200 and 250 milligrams per gram?", "Can you identify an object with a phosphate concentration likely between 100 and 120 milligrams per gram?"], "relational": ["Does the image show a bony structure located on the right side of the body?", "Can you identify a bone that is part of either the axial or appendicular skeleton on the right?", "Is there a bone in the right anatomical region, such as the right arm, right leg, or right thorax?", "Does the image contain a bone that is adjacent to other bones on the right side?", "Can you see a structure that has a contralateral counterpart on the left side, indicating bilateral symmetry?", "Is there a bone associated with synovial, fibrous, or cartilaginous joints on the right side?", "Can you identify a bone with regional skeletal muscles or tendinous attachments nearby?", "Does the image show ligaments connecting to a bone in the right anatomical region?", "Is there evidence of regional peripheral nerves or cutaneous nerves in proximity to a right-sided bone?", "Can you see regional arteries, veins, or nutrient arteries supplying a bone on the right side?", "Does the image show a bone covered by periosteum, connective tissue, or skin on the right side?"], "contexual_behavior": ["Does the image show a structure on the right side that might have reduced ability to support mechanical load, as seen in osteoporosis or significant bone loss?", "Can you identify a region where impaired remodeling could be occurring due to decreased osteoblastic activity and increased resorption, as in osteoporosis?", "Is there evidence of increased bone formation on the right surface, possibly indicating healing after injury with osteoblast recruitment?", "Does the image suggest decreased mineralization on the right surface, which could be due to vitamin D deficiency affecting calcium and phosphate metabolism?", "Can you see signs that the protective function of a right-sided bone surface is compromised, as might happen with infection or osteomyelitis?", "Is there a region on the right where increased bone resorption may be occurring due to inflammation and osteoclast activation?", "Does the image reveal microdamage or signs of repair failure on the right surface, possibly resulting from repetitive stress and insufficient remodeling?", "Can you identify a right-sided area where increased osteoclastic activity might be releasing calcium, as would occur during hypocalcemia?", "Is there visual evidence of reduced structural integrity on the right surface, potentially due to metabolic bone disease affecting the bone matrix?", "Does the right-sided bone surface appear to have altered remodeling rate, possibly due to immobilization and decreased mechanical loading?", "Is there a region on the right where osteoblastic activity seems increased, suggesting new bone formation and repair after a fracture?", "Can you see features on the right surface that indicate decreased resistance to fracture, as might be expected with aging and reduced bone mass?", "Does the image show impaired healing on the right surface, which could be associated with diabetes and vascular complications?", "Is there evidence of increased bone turnover on the right, possibly due to elevated parathyroid hormone as seen in hyperparathyroidism?", "Can you identify a right-sided bone surface where function appears reduced, potentially due to chronic corticosteroid use suppressing osteoblasts and increasing resorption?"], "functions": ["Is there a structure in the image that provides support to maintain body shape and posture?", "Can you identify an object that acts as a physical barrier to protect internal organs?", "Does the image show a structure that serves as a rigid lever for muscle action and joint movement?", "Is there a visible feature that provides attachment sites for muscles to enable force transmission?", "Can you see an object that acts as a reservoir for minerals such as calcium and phosphorus?", "Does the image include a structure that houses bone marrow for blood cell production?", "Is there a part that helps regulate calcium levels in the body by storing or releasing minerals?", "Can you identify a structure that acts as a pivot point to facilitate movement at joints?", "Is there an object that distributes mechanical forces to reduce impact on joints and absorb shock?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a mass located within the kidney?", "Can you identify a lesion with bland cytology and lacking significant atypia?", "Is there a lesion situated in the renal parenchyma, possibly near the cortex or medulla?"], "contexual_behavior": [], "functions": ["Does the image show a benign growth with papillary architecture?", "Is there a structure that might be interfering with tissue organization or potentially obstructing a duct or lumen?", "Is there evidence of a structure that could disrupt normal glandular secretion?"]}}, "brain": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears swollen, which could indicate conditions like cerebral edema or infection?", "Is there evidence of shrinkage or reduced size in a structure that might be associated with aging or neurodegenerative diseases?", "Can you identify an area with decreased volume that could be related to disorders such as Alzheimer's disease or malnutrition?", "Does the image reveal abnormal lesions that might suggest multiple sclerosis, stroke, or a tumor?", "Is there visible accumulation of fluid within a structure, as seen in hydrocephalus or meningitis?", "Can you detect regions with increased iron deposition, which may occur in neurodegenerative diseases like Parkinson's disease?", "Is there a change in color, such as pallor or discoloration, that could result from hypoxia or hemorrhage?", "Does the structure appear softer than normal, possibly due to liquefactive necrosis or severe hypoxic injury?", "Is there evidence of increased firmness, which might be caused by chronic gliosis or calcification?", "Can you see plaques or deposits that are characteristic of Alzheimer's disease or demyelinating disorders?", "Are there increased white matter lesions visible, which could be associated with aging or small vessel disease?", "Does the image suggest atrophy, as seen in chronic neurodegenerative diseases or after prolonged injury?", "Is there any indication of increased intracranial pressure, such as compression or displacement of adjacent structures?", "Can you identify hemorrhages that might be due to hypertension, trauma, or coagulopathies?", "Is there evidence of abnormal electrical activity, which could be related to epilepsy or encephalopathy?", "Can you detect amyloid accumulation, as seen in Alzheimer's disease or cerebral amyloid angiopathy?", "Does the structure display abnormal tissue density, which may be present in stroke, tumors, or demyelinating diseases?", "Is there a region with altered metabolic activity, either increased or decreased, that could suggest epilepsy, tumors, or neurodegenerative diseases?", "Can you see calcifications that might be due to congenital infections, metabolic disorders, or chronic infarcts?", "Is there evidence of changes in neurotransmitter-related features, which could be associated with psychiatric disorders or Parkinson's disease?"], "properties": ["Is there a structure in the image that has an irregular, convoluted surface with visible gyri and sulci?", "Can you identify an object that appears pale grayish-pink in color?", "Does the image show a structure whose size could be approximately 15 centimeters in length and 14 centimeters in width?", "Is there an object present that could have a volume between 1,200 and 1,500 milliliters?", "Can you see a structure that is likely to contain cell types such as neurons, astrocytes, or oligodendrocytes?", "Is there evidence of a region that could contain around 86 billion neurons?", "Does the image include a structure where the number of glial cells might be roughly equal to or slightly greater than the number of neurons?", "Can you identify an object that might have a gray matter to white matter ratio of about 1.3 to 1?", "Is there a structure that could have a water content of approximately 75% to 80% by weight?", "Does the image show an object that might have a lipid content of about 10% to 12% of its wet weight?", "Is there a region that could contain myelin making up about 20% of its dry weight?", "Can you see a structure that might have a cholesterol content of 15 to 20 milligrams per gram of tissue?", "Is there an object that could have an iron concentration ranging from 30 to 60 micrograms per gram, depending on the region?", "Does the image include a structure that typically maintains a temperature between 36.5 and 38 degrees Celsius?", "Can you identify an object that would normally have a pH between 7.1 and 7.4?", "Is there a region that could consume oxygen at a rate of about 3.5 milliliters per 100 grams per minute?", "Does the image show a structure where the glucose concentration might be between 0.7 and 2.5 millimoles per liter?", "Can you see an object that would likely have a protein content of approximately 8% to 10% of its wet weight?", "Is there a structure present that could weigh between 1,300 and 1,400 grams in an adult human?"], "relational": ["Does the image show a structure that is part of the nervous system?", "Can you identify regions such as the cerebrum, cerebellum, or brainstem in the image?", "Is there a structure that connects directly to the spinal cord via the brainstem or medulla oblongata?", "Are protective membranes like the dura mater, arachnoid mater, or pia mater visible surrounding any structure?", "Does the image include blood vessels such as the internal carotid arteries or vertebral arteries supplying a central organ?", "Can you see internal cavities resembling ventricles, such as the lateral, third, or fourth ventricle?", "Is there evidence of cranial nerves, such as the optic nerve or other nerves originating from a central structure?", "Does the image show a structure protected by the bones of the cranium or skull?", "Are there areas distinguishable as gray matter or white matter within a central organ?", "Can you identify neural tissue or glial cells within any structure present?", "Is there a principal organ of the central nervous system coordinating with the spinal cord visible in the image?"], "contexual_behavior": ["Does the image show a structure that reduces its processing speed during normal aging or neurodegenerative conditions?", "Can you identify an area that would increase neural activity in response to stress via the hypothalamic-pituitary-adrenal axis?", "Is there a structure whose memory formation could be impaired by sleep deprivation affecting REM and slow-wave sleep?", "Does the image contain a region where neurotransmitter release, such as serotonin, norepinephrine, or dopamine, might be decreased in depression?", "Can you see an area that enhances synaptic plasticity during learning through mechanisms like long-term potentiation?", "Is there a structure that fails to regulate motor control in Parkinson\u2019s disease due to degeneration of dopaminergic neurons?", "Does the image show a region that would increase glucose uptake during intense mental activity?", "Can you identify a structure that reduces oxygen consumption during anesthesia as neural activity decreases?", "Is there an area that alters its function during hypoxia by shifting to anaerobic metabolism and reducing neuronal activity?", "Does the image contain a region that shows decreased responsiveness under sedation due to suppression of cortical and subcortical activity?", "Can you see a structure that increases pain perception in chronic pain conditions through central sensitization?", "Is there an area that fails to coordinate sensory input after injury when neural pathways are disrupted by trauma or stroke?", "Does the image show a region that enhances neuroprotection during mild hypothermia by reducing metabolic demand?", "Can you identify a structure that reduces executive function during aging as prefrontal cortex efficiency declines?", "Is there an area that increases neuroinflammation in neurodegenerative diseases due to activation of microglia and astrocytes?", "Does the image contain a region that alters its activity during meditation by modulating the default mode network and increasing alpha wave activity?", "Can you see a structure that shows impaired signal transmission in multiple sclerosis due to demyelination of central nervous system axons?", "Is there a region that increases blood flow during physical exercise to supply active neurons with oxygen and nutrients?", "Does the image show a structure that reduces its ability to regulate emotions in anxiety disorders due to dysregulation of limbic and prefrontal circuits?", "Can you identify an area that fails to maintain homeostasis during severe trauma when autoregulatory mechanisms are overwhelmed?"], "functions": ["Does the image contain a structure responsible for cognition and perception?", "Is there an object that controls movement by sending signals to muscles?", "Can you identify a region involved in processing sensory information?", "Does the image show structures such as the amygdala or limbic system that regulate emotions?", "Is there a visible area associated with memory formation, such as the hippocampus?", "Can you see regions like the basal ganglia or cerebellum that coordinate voluntary actions?", "Does the image include a structure that regulates hormone release through the pituitary gland?", "Is there an area related to language comprehension or production, such as Broca\u2019s or Wernicke\u2019s area?", "Can you identify a region that maintains homeostasis by adjusting bodily functions?", "Does the image show centers like the medulla oblongata or brainstem involved in regulating breathing and heart rate?", "Is there a structure supporting learning and cognition through neural plasticity?", "Can you see association areas that integrate information from multiple senses?", "Is there a region involved in regulating sleep and circadian rhythms?", "Does the image contain a structure that participates in the stress response by activating the HPA axis?", "Can you identify an area involved in decision making, such as the prefrontal cortex?"]}, "no_questions": {"contexual_properties": ["Does the image contain a region located at the lower back part of the cranial cavity?", "Is there a visible space that could be associated with the posterior aspect of the brain?", "Can you identify an area that is situated near the base of the skull and behind the temporal bone?"], "properties": ["Does the image show a concave, irregularly shaped region conforming to the cranial base?", "Is there a structure with bone thickness ranging from 3 to 8 millimeters?", "Does the image display bone with a pale yellowish-white coloration?"], "relational": ["Can you identify a region where the temporal fossa is situated superior and lateral to another fossa at the posterior cranial base?", "Does the image show dural folds like the tentorium cerebelli or falx cerebelli?", "Can you see major blood vessels like the internal carotid artery or vertebral artery in proximity to a cranial region?"], "contexual_behavior": ["Can you identify a space that might be found beneath the tentorium cerebelli?", "Does the image show a region that could house structures such as the cerebellum or brainstem?", "Does the image contain a region located at the base or back of the skull?"], "functions": ["Is there a region that supports motor coordination by housing the cerebellum and its neural connections?", "Does the image include areas or pathways involved in auditory, vestibular, or somatosensory processing?", "Does the image show a region that houses structures responsible for sensory processing or motor coordination?"]}}, "odontoid process subluxation": {"yes_questions": {"contexual_properties": ["Does the image show abnormal alignment at the atlantoaxial joint that could be worsened by trauma or inflammatory arthritis?", "Is there evidence of increased displacement between the first and second cervical vertebrae that might indicate ligament injury or instability?", "Can you identify signs of abnormal joint space width that could suggest synovial inflammation or joint effusion?", "Does the image reveal narrowing of the spinal canal due to posterior displacement of a cervical structure, potentially compressing the spinal cord?", "Are there visible changes in bone structure, such as remodeling or erosion, that might result from chronic instability?", "Is there swelling of tissues around the upper cervical spine that could be due to acute trauma or an inflammatory response?", "Can you see an increased gap between the atlas and a peg-like projection, possibly indicating rupture or laxity of the transverse ligament?", "Does the cervical spine show abnormal curvature that could be a compensatory change from chronic misalignment?", "Are there features suggesting weakened or degenerated ligaments supporting the atlantoaxial joint?", "Is there evidence of bone erosion at the atlantoaxial joint that could be associated with chronic inflammation or rheumatoid arthritis?", "Can you identify signs of increased joint laxity in the upper cervical region, possibly related to connective tissue disorders?", "Are there imaging findings such as sclerosis or pannus formation that would indicate chronic changes at the atlantoaxial joint?", "Does the image appear to be taken during flexion or extension, or does it use advanced imaging modalities like MRI to better reveal instability at the upper cervical spine?"], "properties": ["Does the image show a structure with displacement measuring between 3 and 5 millimeters?", "Is there evidence of angulation at the atlantoaxial joint in the range of 10 to 20 degrees?", "Can you identify anterior or posterior translation between C1 and C2 that is less than 5 millimeters?", "Is the atlantodental interval greater than 3 millimeters in an adult or greater than 5 millimeters in a child?", "Does the image reveal malalignment or a step-off between the anterior arch of the atlas and an adjacent bony process?", "Is there any sign of bone edema that might indicate an acute or traumatic injury on MRI?", "Can you observe cortical irregularity in a region that could be affected by chronic inflammatory conditions such as rheumatoid arthritis?", "Does the MRI show low signal intensity on T1-weighted images and high signal on T2-weighted images in a relevant bony structure, suggesting edema?", "Is there prevertebral soft tissue swelling greater than 6 millimeters at the level of the second cervical vertebra in an adult?", "Can you see abnormal alignment with anterior or posterior displacement of a bony process relative to the anterior arch of the atlas?"], "relational": ["Is there evidence of abnormal alignment at the joint connecting the first and second cervical vertebrae?", "Does the image show any displacement involving the upper cervical spine?", "Can you identify any irregular relationship between the atlas and axis bones?", "Is there a visible disruption of the articulation between the anterior arch of the atlas and the structure projecting from the axis?", "Does the image suggest involvement of ligaments such as the transverse ligament or alar ligaments in the upper cervical region?", "Is there any indication that joint capsules or neural tissue near the upper cervical spinal cord segments might be affected?", "Can you see any abnormal proximity or compression of the spinal cord adjacent to the first and second cervical vertebrae?", "Is there a structure in the axial skeleton of the musculoskeletal system that appears misaligned at the level of C1 and C2?", "Does the image reveal any alteration in the position of tissues near the tectorial membrane or anterior arch of the atlas?"], "contexual_behavior": ["Does the image show evidence of instability in the upper cervical spine, such as abnormal alignment between the first and second cervical vertebrae?", "Can you identify any signs of displacement at the atlantoaxial joint that might compromise ligamentous support?", "Is there visible narrowing of the spinal canal at the C1-C2 level that could increase the risk of spinal cord compression?", "Does the image suggest reduced range of motion or stiffness in the neck due to abnormal joint positioning?", "Are there features consistent with inflammatory changes, such as those seen in rheumatoid arthritis, affecting the atlantoaxial region?", "Can you see any indications of neural structure compression that might lead to impaired neural transmission or nerve root involvement?", "Is there evidence of vascular compromise, such as compression of the vertebral artery, that could affect blood flow to the brainstem?", "Does the alignment of the cervical vertebrae suggest disruption of normal proprioceptive feedback from the neck?", "Are there signs that trauma or sudden movement has resulted in increased mechanical stress or instability at the atlantoaxial joint?", "Can you identify features that might indicate compromised respiratory function due to involvement of neural pathways controlling respiratory muscles?", "Is there any indication of neural compression at the cervicomedullary junction that could impair swallowing or vocalization?", "Does the image show abnormal joint movement or tissue irritation that could be associated with increased pain during neck rotation?", "Are there signs of ligamentous laxity or structural weakness reducing the effectiveness of cervical spine support structures?", "Can you see evidence of dynamic instability or transient compression of neural elements that might occur during physical activity?", "Does the image reveal malalignment of the atlantoaxial joint under mechanical stress, suggesting ligamentous insufficiency?", "Are there indications that immobilization or surgical stabilization has been used to restore normal alignment and prevent further displacement in the cervical spine?"], "functions": ["Does the image show evidence of instability in the cervical spine that could increase the risk of abnormal vertebral motion or spinal cord injury?", "Is there a visible indication of spinal cord compression or stretching that might result in impaired motor or sensory function below a certain level?", "Can you identify any signs of mechanical deformation or ischemia in the cervical spinal cord that could disrupt neural signal transmission?", "Does the image suggest restricted or altered head and neck movement due to instability, pain, or a mechanical blockage?", "Is there any evidence of vertebral artery compression or kinking that could compromise blood flow and increase the risk of ischemic events?", "Can you see features that might contribute to neurological deficits such as weakness, numbness, or paralysis by damaging neural structures in the cervical region?", "Does the image reveal any impairment of respiratory function that could be linked to neural control disruption or direct compression of the medulla?", "Is there any indication of disrupted proprioceptive feedback from the cervical spine, such as abnormal joint alignment or altered sensory input?", "Can you identify signs of impaired protective reflexes in the neck, such as issues with the head righting reflex, due to instability or altered neural signaling?", "Does the image show abnormal alignment or biomechanics of the cervical vertebrae that could lead to uneven load distribution or increase the risk of degenerative changes?"]}, "no_questions": {"contexual_properties": [], "properties": ["Are there vesicles present that contain serous fluid?", "Do you observe between 20 and 100 lesions grouped in a localized area?", "Is there any indication that the fluid within the vesicles might have a mildly alkaline pH, around 7.4 to 7.6?"], "relational": ["Does the image show features that could be explained by processes in the peripheral or central nervous system, particularly involving sensory ganglia?", "Is there evidence of changes in areas innervated by sensory nerves, cranial nerves, or spinal nerves?", "Can you identify lesions involving the epidermis or dermis?"], "contexual_behavior": [], "functions": ["Is there evidence of tissue inflammation that could be explained by the release of pro-inflammatory cytokines or immune cell recruitment?", "Can you see any indications of disrupted skin barrier function, like open lesions or areas susceptible to secondary infection?", "Does the image show patterns of skin involvement that follow nerve pathways, suggesting anterograde axonal spread to peripheral tissues?"]}}, "narrowing of foramen magnum": {"yes_questions": {"contexual_properties": ["Does the image show evidence of abnormal bone growth or thickening at the craniovertebral junction?", "Can you identify a region where the diameter of a major cranial opening appears reduced compared to normal anatomy?", "Is there visible compression or deformation of neural or vascular structures near the base of the skull?", "Does the image reveal increased bone density or excessive bone deposition in the area where the skull meets the spine?", "Are there signs of altered bone composition suggestive of conditions like osteopetrosis or metabolic bone disease?", "Can you observe imaging findings that indicate a constricted aperture affecting cerebrospinal fluid flow?", "Is there evidence of impingement or deformation of the brainstem or upper spinal cord by adjacent bone structures?", "Does the image suggest rapid progression of bone changes, especially in a pediatric patient or in the context of an aggressive skeletal disorder?", "Are there radiographic or MRI features showing abnormal contours or margins of the cranial base opening?", "Can you see changes in the shape of the cranial opening that might result from bone remodeling or disease progression?", "Is there a visible reduction in the space available for neural or vascular structures at the craniovertebral junction?", "Does the image show features consistent with sclerosing bone dysplasia in the region where the skull and spine connect?", "Are there signs of compromised cerebrospinal fluid circulation due to a narrowed cranial base opening?", "Can you detect any deformation of adjacent anatomical structures resulting from bone overgrowth at the craniovertebral junction?"], "properties": ["Does the image show an opening at the base of the skull with a diameter less than 30 mm?", "Can you identify a structure whose width is below the normal range of 30 to 35 mm?", "Is there evidence of an opening with more than a 20% reduction in area compared to typical size?", "Does the sagittal diameter of the visible cranial opening appear to be less than 30 mm?", "Can you see a foramen with a transverse diameter under 25 mm?", "Is there an opening that appears more oval or constricted than the usual round or oval shape?", "Can you classify the degree of narrowing of the cranial opening as mild, moderate, or severe based on its dimensions?", "Does the cross-sectional area of the opening appear to be less than 500 mm\u00b2?", "Is there increased bone thickness at the margins of the opening, possibly exceeding 5 mm?", "Does the ratio of the opening's dimensions appear to be less than 0.8 compared to standard proportions?"], "relational": ["Is there evidence of a reduced opening at the cranial base where the medulla oblongata and vertebral arteries pass through?", "Can you observe any abnormal narrowing in the large aperture formed by the occipital bone?", "Does the image show any compression or crowding of structures such as the lower brainstem or upper spinal cord near the base of the skull?", "Is there a visible alteration in the continuity between the cranial cavity and the vertebral canal?", "Can you detect any signs of bony overgrowth or thickened tissues at the boundary of the occipital bone?", "Are there indications of congenital malformation affecting the area where the spinal cord exits the skull?", "Does the region adjacent to the cerebellum and clivus appear constricted?", "Is there any visible impact on the dura mater, arachnoid mater, or pia mater at the cranial base opening?", "Can you see any structural changes in the axial skeleton at the junction between the skull and vertebral column?", "Are the accessory nerves or vertebral arteries visibly compressed as they traverse the opening at the base of the skull?"], "contexual_behavior": ["Does the image show evidence of obstruction to cerebrospinal fluid flow between the cranial and spinal compartments?", "Is there any indication of increased risk for brainstem compression during head movement due to restricted space at the craniovertebral junction?", "Can you identify features suggesting reduced neural signal transmission between the brain and spinal cord at the craniovertebral junction?", "Does the image provide clues of impaired respiratory function during sleep, possibly due to compression of brainstem centers controlling breathing?", "Is there any sign of compromised blood flow to the brain during physical exertion, such as compression of vascular structures at the craniovertebral junction?", "Can you see evidence of decreased swallowing efficiency that might result from compression of lower cranial nerves at the craniovertebral junction?", "Does the image suggest exacerbation of symptoms during episodes of increased intracranial pressure, possibly due to a restricted outlet for CSF or blood flow?", "Is there any indication of impaired motor coordination in a pediatric subject, potentially due to compression of developing neural tracts during growth?", "Can you identify features that suggest reduced protective function of the craniovertebral junction during trauma, increasing vulnerability of neural structures?", "Does the image show signs of altered venous drainage from the brain, such as congestion from compression of venous sinuses or veins at the craniovertebral junction?", "Is there any evidence of impaired temperature regulation that could be explained by autonomic dysfunction from compression of descending fibers at the craniovertebral junction?", "Can you see features that would lead to more severe neurological deficits during infection or inflammation, possibly due to further reduction of available space for neural tissue?", "Does the image suggest increased risk of sudden cardiorespiratory compromise, such as compression of vital centers in the medulla during acute events?", "Is there any indication of disrupted growth and development of the nervous system, potentially due to chronic compression at the craniovertebral junction?", "Can you identify signs that the narrowing worsens during periods of rapid skeletal growth, such as disproportionate bone development further restricting the foramen\u2019s diameter?"], "functions": ["Does the image show evidence of compression of neural or vascular structures that could lead to impaired neurological function?", "Is there any indication of cerebrospinal fluid flow obstruction that might increase the risk of hydrocephalus or intracranial hypertension?", "Can you identify features suggesting disruption of neural signal transmission between the brain and spinal cord?", "Is there visible compromise of brainstem structures that could result in deficits in autonomic or motor control?", "Does the image reveal signs of impaired cerebrospinal fluid dynamics or venous outflow that could contribute to raised intracranial pressure?", "Is there any indication of compression affecting the medulla that might cause abnormal breathing or heart rate regulation?", "Can you see evidence of spinal cord compression at the junction with the skull, potentially leading to motor or sensory deficits below that level?", "Are there visual cues suggesting neurological symptoms such as headache, neck pain, ataxia, or weakness due to compromise of neural structures?", "Does the image show possible compression of cranial nerves that could result in dysphagia or vocal cord paralysis?", "Is there any indication of impaired movement or coordination that could be explained by dysfunction of cerebellar or corticospinal pathways?"]}, "no_questions": {"contexual_properties": ["Do you see an object with increased granularity, which could be a sign of metabolic activity or ingestion of material?", "Is there a visible change in nuclear appearance that could be associated with mitosis or cellular stress?", "Does the image show a structure that appears to be increasing in number, suggesting active cell division or asexual reproduction?"], "properties": [], "relational": ["Does the image contain cells such as epithelial cells, hepatocytes, or immune cells at a potential site of infection?", "Is there evidence of anatomical barriers such as the intestinal epithelium or mucosal barrier present in the image?", "Can you identify a region within the abdominal cavity or hepatic region that may be relevant?"], "contexual_behavior": [], "functions": ["Does the image include an area that could modulate access to growth factors or environmental cues for protozoan development?", "Is there a structure present that supplies essential nutrients and optimal conditions for the growth of protozoan cells?", "Can you identify a substrate that could present signals or molecules triggering developmental changes in protozoan cells?"]}}}
[ { "answer": "proliferating stromal cells", "extracted_concepts": [ "surrounding stroma", "proliferating stromal cells", "glandular tissue", "cleftlike spaces" ], "question": "what distorts the glandular tissue, forming cleftlike spaces, and bulges into surrounding stroma?" }, { "answer": "the glandular tissue", "extracted_concepts": [ "glandular tissue", "proliferating stromal cells" ], "question": "what do proliferating stromal cells distort?" }, { "answer": "yes", "extracted_concepts": [ "surrounding stroma", "glandular tissue", "proliferating stromal cells", "cleftlike spaces" ], "question": "do proliferating stromal cells distort the glandular tissue, forming cleftlike spaces, and bulge into surrounding stroma?" }, { "answer": "no", "extracted_concepts": [ "carcinoid tumors", "surrounding stroma", "glandular tissue", "cleftlike spaces" ], "question": "do carcinoid tumors distort the glandular tissue, forming cleftlike spaces, and bulge into surrounding stroma?" } ]	["carcinoid tumors", "glandular tissue", "proliferating stromal cells", "cleftlike spaces", "surrounding stroma"]	{"carcinoid tumors": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion located within the gastrointestinal, respiratory, or endocrine systems?", "Is there a mass affecting the mucosa or submucosa of an organ?", "Can you identify a growth in neuroendocrine tissue?", "Is there a lesion present in the small intestine, appendix, rectum, or bronchi?", "Does the image reveal a mass adjacent to the muscularis propria, serosa, or mesentery?", "Is there evidence of invasion into the liver, lymph nodes, or peritoneum by a nearby lesion?", "Can you see a tumor composed of neuroendocrine or chromaffin cells?", "Is there a structure with supporting stromal cells associated with a neoplastic process?", "Does the image show involvement of regional lymph nodes, mesenteric lymphatics, or the thoracic duct?", "Is there a mass in proximity to mesenteric veins, the portal vein, or submucosal capillaries?", "Can you observe infiltration of the mucosa, submucosa, muscularis propria, or serosa by a lesion?", "Is there a neoplasm with the appendix as its primary site within the gastrointestinal tract?"], "contexual_behavior": [], "functions": ["Does the image show an abnormal growth that could secrete hormones and disrupt normal tissue processes?", "Is there evidence of a lesion that might be responsible for excessive serotonin or histamine production?", "Can you identify a mass that could be a source of increased systemic serotonin levels?", "Does the image contain a structure that might impair gastrointestinal motility or be associated with symptoms like diarrhea or abdominal pain?", "Is there a lesion that could release vasoactive substances leading to systemic symptoms such as flushing or bronchospasm?", "Can you see a mass that might disrupt local tissue function through invasion or by exerting a mass effect?", "Is there evidence of a tumor that could evade immune surveillance or induce local inflammation?", "Does the image show a growth that might activate cell proliferation or hormone secretion pathways?", "Can you identify a lesion that could interfere with normal metabolic regulation by producing hormones or peptides?", "Is there a structure that might cause vascular changes such as fibrosis, increased blood vessel formation, or altered local blood flow?", "Does the image reveal a mass that could impair nutrient absorption or digestion by affecting intestinal function?", "Is there a lesion that could cause systemic endocrine imbalance through the production of bioactive amines or peptides?", "Can you see evidence of a tumor that may have metastasized to distant organs and continues to secrete hormones at those sites?"]}, "no_questions": {"contexual_properties": ["Does the tissue exhibit altered firmness or consistency, possibly due to the accumulation of additional cells?", "Is there a structure that appears heavier or more massive, possibly due to an increased number of cells?", "Can you see any swelling or expansion in a tissue area that might be caused by an increased cell mass?"], "properties": ["Is there a region where the volume of tissue is increased relative to adjacent areas?", "Does the image show a region where the number of cells is noticeably increased compared to surrounding tissue?", "Is there a region whose degree of enlargement or cellularity might suggest a process that varies in duration depending on the presence of a stimulus?"], "relational": ["Can you identify a structure within the prostate, endometrium, thyroid, or skin that appears enlarged due to cellular proliferation?", "Can you identify a region where the extracellular matrix appears to support an increased population of cells within a defined tissue border?", "Does the image show a region within epithelial or glandular tissue where there appears to be an increased number of cells while maintaining normal tissue organization?"], "contexual_behavior": ["Can you observe abnormal enlargement of an organ that could be associated with impaired function, as seen in disease states like benign prostatic enlargement?", "Can you identify areas where excessive cell proliferation may indicate a pathological process such as neoplasia or cancer?", "Does the image show increased cellular layers or thickening in epithelial tissues exposed to persistent mechanical stress, such as chronic friction or pressure?"], "functions": ["Can you identify a region where cell proliferation appears to have caused organ enlargement?", "Does the image display signs of tissue remodeling or cellular response to physiological demands?", "Can you see features indicating cell proliferation as part of tissue repair or regeneration after injury?"]}}, "glandular tissue": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the endocrine, digestive, or integumentary system?", "Can you identify an organ in the image such as the thyroid gland, pancreas, salivary glands, or mammary glands?", "Is there evidence of a structure that could form either exocrine or endocrine glands?", "Does the image contain cells resembling secretory epithelial cells, myoepithelial cells, or ductal cells?", "Can you see anatomical features adjacent to the structure, such as connective tissue, blood vessels, or nerve fibers?", "Is there a region in the image, such as the neck, abdomen, breast, or oral cavity, that contains specialized tissue for secretion?", "Does the image display ducts like salivary ducts, pancreatic ducts, or mammary ducts?", "Can you identify tissue that appears to be a specialized form of epithelial tissue adapted for secretion?", "Is there a structure in the image that could interact with the liver, kidneys, or small intestine through secretory processes?", "Does the image show tissue that is structurally related to epithelial, connective, or muscle tissue?"], "contexual_behavior": [], "functions": ["Does the image show a structure involved in the secretion of hormones or enzymes?", "Can you identify tissue that releases substances through exocytosis into the bloodstream or ducts?", "Is there a region that regulates body processes by releasing signaling molecules affecting metabolism or growth?", "Does the image contain tissue that adjusts secretion in response to internal or external changes to maintain homeostasis?", "Can you see a structure that aids digestion by releasing digestive enzymes or fluids into the gastrointestinal tract?", "Is there evidence of tissue releasing substances such as sweat, saliva, or digestive juices onto surfaces or into ducts?", "Does the image include a structure that participates in endocrine signaling by releasing hormones directly into the blood?", "Can you identify tissue that alters its secretion rate in response to neural, hormonal, or chemical stimuli?", "Is there a region that helps maintain fluid or electrolyte balance by secreting regulatory hormones?", "Does the image show tissue involved in controlling glucose, lipid, or protein metabolism through hormone production?", "Can you see a structure that supports immune defense by secreting antimicrobial peptides or mucins?", "Is there tissue present that plays a role in reproductive functions by producing hormones or fluids for gamete maturation or lactation?", "Does the image contain a region that modulates the local tissue environment by releasing factors influencing cell growth or inflammation?"]}, "no_questions": {"contexual_properties": ["Can you identify regions where linear arrangements of cells show increased cellularity, as seen in neoplasia or reactive hyperplasia?", "Are there any linear cellular structures exhibiting calcification, as seen in dystrophic or metastatic calcification?", "Are there linear cellular structures that appear more prominent, suggesting a fibrotic or reparative tissue response?"], "properties": ["Is there a structure present where the width is approximately one to two cells across, measuring about 10\u201330 micrometers?", "Is there a visible feature with a high length-to-width ratio, possibly exceeding 10:1?", "Can you identify any features that appear as single-file or parallel arrangements of cells?"], "relational": ["Can you identify an organ, such as the liver, adrenal gland, or parathyroid gland, that displays linear arrangements of its cellular components?", "Does the image display regions where hepatocytes, adrenal cortical cells, or parathyroid chief cells are arranged in a linear fashion?", "Can you identify structures in the abdominal cavity, neck, or retroperitoneal space that are composed of elongated groups of cells?"], "contexual_behavior": ["Is there evidence of increased cellular proliferation or activity in response to tissue damage or wound healing?", "Is there evidence of disrupted tissue architecture or loss of polarity that might indicate malignant transformation or cancerous conditions?", "Is there evidence of impaired differentiation among cells, potentially due to mutations affecting developmental signaling pathways in genetic disorders?"], "functions": ["Is there evidence of pathways that could facilitate direct cell-to-cell contact and communication?", "Do you see any arrangements that might serve as templates for proliferating or migrating cells during tissue repair?", "Can you find structures that might establish the initial architecture for organ-specific development?"]}}, "proliferating stromal cells": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a tissue type such as bone marrow, endometrium, or tumor stroma?", "Can you identify a region that is part of the reproductive, hematopoietic, or musculoskeletal system?", "Is there evidence of cell types like fibroblasts or mesenchymal stem cells within the tissue?", "Does the image display interactions between connective tissue cells and blood vessels or epithelial layers?", "Are there visible extracellular matrix components such as collagen or fibronectin present in the tissue?", "Can you see a region from organs like the uterus, bone, lymph nodes, or skin that contains specialized connective tissue cells?", "Is there a structure that could be classified as connective tissue?", "Does the image include cells that might be pericytes, adipocytes, or endothelial cells adjacent to other stromal cells?", "Can you identify a body region such as the pelvic cavity, long bones, or subcutaneous tissue that contains specialized stromal cells?", "Is there a visible microenvironment, such as a stem cell niche or perivascular region, that could support the proliferation of certain stromal cells?"], "contexual_behavior": [], "functions": ["Does the image show cells that could be providing structural support within the tissue?", "Can you identify cells that might be secreting growth factors to influence their surroundings?", "Is there evidence of cell populations involved in tissue remodeling or regeneration?", "Does the image display cells that appear to be proliferating or differentiating to replace damaged tissue components?", "Are there cells visible that could be migrating toward an injury site as part of wound healing?", "Can you see evidence of extracellular matrix production, such as collagen or fibronectin deposition?", "Is there a cell population that might be creating a supportive microenvironment for tissue repair?", "Are there cells that seem to be supporting neighboring cell types through structural scaffolding or secreted factors?", "Does the image show cells that could be interacting with immune cells or modulating local immune responses?", "Is there evidence of angiogenesis, such as support for endothelial cell migration or new vessel formation, possibly influenced by local cell populations?", "Can you identify cells that might be balancing matrix turnover or maintaining tissue homeostasis?", "Is there any indication of interactions between stromal and cancer cells that could promote tumor progression or immune evasion?", "Does the image show signs of inflammation modulation, such as the presence of cells producing cytokines in response to the tissue context?", "Are there features suggesting excessive extracellular matrix deposition or tissue scarring, indicative of fibrosis?", "Can you see cells that might be responding to local growth factors or cytokines, as evidenced by changes in proliferation, migration, or differentiation?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see something with a volume of about 6.5 to 7 milliliters in adult humans?", "Does the image include an object with a firm exterior and a gelatinous interior?", "Is there a structure that contains tissues such as retina, cornea, lens, sclera, choroid, and vitreous body?"], "relational": ["Does the image show a structure that is part of the visual or sensory system?", "Is there evidence of neural, connective, epithelial, or vascular tissue within any dissected structure?", "Does the image display components like the sclera, iris, choroid, or vitreous body?"], "contexual_behavior": ["Can you identify a sample where neurotransmitter release could be altered due to metabolic stress affecting synaptic function?", "Is there a structure that would demonstrate reduced adaptation to changing light conditions after photobleaching impairs photopigment recovery?", "Does the image show a specimen that could recover functional activity after reoxygenation following an anoxic period?"], "functions": ["Does the image include a model that could be used to investigate pathophysiological changes associated with ocular diseases?", "Does the image contain tissue that could be used to investigate synaptic activity within the retina or optic nerve?", "Is there evidence of a preparation that would allow researchers to access neural circuits involved in image formation?"]}}, "cleftlike spaces": {"yes_questions": {"contexual_properties": ["Does the image show spaces that appear enlarged in areas affected by swelling or cyst formation?", "Can you identify regions where the number of spaces increases in association with tissue degeneration or chronic inflammation?", "Is there evidence of fluid-filled spaces that could indicate serous effusion or exudate accumulation?", "Do you see abnormal spaces in locations suggestive of developmental anomalies, neoplastic growth, or tissue injury?", "Are there spaces whose shape appears altered due to compression, fibrosis, or remodeling of the surrounding tissue?", "Can you observe spaces that are more prominent in regions with increased fluid content or tissue breakdown?", "Is there visual evidence of spaces containing cellular debris, possibly due to necrosis, apoptosis, or inflammatory infiltration?", "Do any spaces appear to have thickened walls, which might suggest chronic inflammation, fibrosis, or scarring?", "Can you identify spaces that have decreased in size, potentially indicating resolution of edema or tissue repair?", "Are there spaces with accumulation of proteinaceous material, possibly due to increased vascular permeability or protein leakage?", "Do you see spaces that are compressed by adjacent masses, tumors, or areas of increased interstitial pressure?", "Is there evidence of hemorrhage within spaces, such as might occur with trauma or vascular rupture?", "Are there spaces with irregular outlines, which could be associated with necrosis, malignancy, or chronic inflammation?", "Can you observe spaces that appear in regions affected by neurodegeneration or ischemic injury?", "Is there visual evidence of increased permeability in spaces, as might occur in inflammatory or allergic conditions?"], "properties": ["Does the image show any elongated, narrow, or slit-like regions within the tissue?", "Can you identify clear or pale areas with sharply defined edges that appear empty or contain little cellular material?", "Are there structures present that measure only a few micrometers to several millimeters in size?", "Is there any region whose width is less than 1 micrometer or extends up to several millimeters?", "Can you find areas that are several times longer than they are wide?", "Does the image contain small spaces whose volume would likely be in the microliter or nanoliter range?", "Are there regions that appear colorless or pale due to a lack of cellular content?", "Can you see spaces that may contain interstitial fluid, extracellular matrix, or appear empty?", "Is there evidence of spaces with no obvious lining, or lined by flattened endothelial or epithelial cells?", "Do you observe any structures with very thin or absent walls, possibly formed by a single cell layer?", "Are there irregularly scattered or infrequently occurring slit-like spaces, possibly following connective tissue planes?", "Can you see any variability in the distance between adjacent narrow spaces, depending on the tissue context?"], "relational": ["Does the image show a region within epithelial, connective, or glandular tissue that appears as a narrow space?", "Can you identify a structure that contributes to the formation of glandular acini or synovial cavities?", "Is there a feature present in the integumentary, musculoskeletal, or endocrine system that resembles a slit-like space?", "Do you observe a space lined by epithelial cells, endothelial cells, or synoviocytes?", "Is there a narrow gap bordered by connective tissue that might provide structural support?", "Can you see a space located in or near joints, salivary glands, or skin?", "Is there a region adjacent to a basement membrane, capillaries, or parenchymal cells that appears as a cleft?", "Does the image contain a space that could hold interstitial fluid, synovial fluid, or secretions?", "Can you identify a larger anatomical feature, such as a synovial membrane, glandular lobule, or dermal layer, that is composed of multiple narrow spaces?", "Is there evidence of synovial clefts, intercellular clefts, or glandular clefts in the depicted tissue?"], "contexual_behavior": ["Does the image show evidence of increased fluid exchange that could occur during inflammation when endothelial junctions are loosened?", "Can you identify areas where immune cell migration might be facilitated, as would happen during infection when cytokines widen intercellular gaps?", "Is there visual indication of enlarged spaces that could be associated with pathological edema due to excessive fluid leakage?", "Does the image suggest reduced permeability, as might be seen during dehydration when endothelial cells contract and junctions tighten?", "Can you observe features that might indicate barrier dysfunction, such as the passage of large molecules, which could occur in disease states with disrupted structural proteins?", "Is there evidence of increased nutrient diffusion, possibly related to tissue repair when growth factors temporarily loosen cell junctions?", "Does the image show signs of impaired waste removal or fluid movement, as might be seen in hypoxic conditions?", "Can you identify abnormal fluid accumulation that could be linked to elevated venous pressure, as seen in heart failure?", "Is there any indication of altered barrier function, such as increased vascular permeability, that might occur during an allergic reaction due to histamine release?", "Does the image suggest reduced intercellular communication, as might happen under stress when gap junction activity is downregulated?"], "functions": ["Does the image show narrow gaps between adjacent cells that could facilitate the movement of fluids or cells within tissue?", "Can you identify structures that might provide low-resistance pathways for paracellular transport or cell migration?", "Is there evidence of selective permeability between cells, suggesting a paracellular pathway for molecules and ions?", "Does the tissue display features that would permit nutrient diffusion from capillaries to surrounding cells?", "Can you see intercellular spaces that could allow metabolic byproducts to diffuse toward capillaries for clearance?", "Is there a visible route for signaling molecules or mediators to pass between neighboring cells, supporting cell communication?", "Does the image suggest the presence of pathways that could influence local concentration gradients of signaling molecules within the tissue?", "Can you observe structures that might regulate tissue hydration by permitting water and electrolyte movement between cells and the extracellular matrix?", "Is there a potential conduit for immune cells, such as leukocytes, to traverse tissue barriers during immune surveillance?", "Does the tissue architecture allow for the diffusion of gases like oxygen and carbon dioxide between capillaries and cells through intercellular gaps?"]}, "no_questions": {"contexual_properties": ["Can you identify regions that appear different from the surrounding brain structures?", "Does the image show any abnormal areas within neural tissue?", "Is there evidence of localized changes in the tissue that could indicate pathology?"], "properties": ["Can you identify regions where the mitotic index appears elevated or variable, suggesting increased cell proliferation?", "Is there a pattern of increased hematoxylin and eosin staining or positivity for immunohistochemical markers in certain areas?", "Do you see pigment deposits, such as hemosiderin or melanin, within any of the affected areas?"], "relational": ["Can you identify adjacent structures such as ventricles in proximity to the abnormal area?", "Are any of the meningeal membranes, such as dura mater, arachnoid mater, or pia mater, visible surrounding the abnormal tissue?", "Does the image show a structure that is part of the central nervous system?"], "contexual_behavior": ["Is there a region that might indicate impaired neurotransmitter release due to hypoxic conditions?", "Does the image reveal network disruptions that could alter functional connectivity during sleep deprivation?", "Is there visible damage to regions involved in synaptic remodeling, potentially reducing neuroplasticity after injury?"], "functions": ["Is there any indication of disruption in areas responsible for regulatory activities like homeostasis or circadian rhythms?", "Are there visible features that might be associated with impaired memory or learning processes?", "Does the slide display abnormalities that might correspond to compromised motor control or coordination?"]}}, "surrounding stroma": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region composed mainly of extracellular matrix, cells, and interstitial fluid?", "Can you identify an area that contains fibroblasts, macrophages, or endothelial cells?", "Is there a structure with a thickness that could fall within the range of 50 to 500 micrometers?", "Does the image include a region that appears pale pink or whitish in color?", "Can you see an area with a soft and fibrous texture?", "Is there a region where fibroblasts seem to make up the majority of the cellular population?", "Does the image show a structure with low cellularity, such as about 1,000 to 10,000 cells per cubic millimeter?", "Can you identify an area where the extracellular matrix appears to occupy most of the volume?", "Is there a region that might have a high collagen content, making up the majority of its dry weight?", "Does the image include a structure that could have a water content of around 60 to 70 percent by weight?", "Can you see an area that might contain elastic fibers as a small proportion of the total matrix?", "Is there a region where glycosaminoglycans could be present at a concentration of 1 to 5 milligrams per gram of tissue?", "Does the image show a structure that might have a density between 1.05 and 1.10 grams per cubic centimeter?", "Can you identify an area where the protein content could be around 20 to 30 percent of its dry weight?", "Is there a region that would be expected to have a pH close to neutral, around 7.2 to 7.4?"], "relational": ["Does the image show tissue that could be classified as loose or dense connective tissue?", "Can you identify fibrous tissue adjacent to epithelial layers or parenchymal regions?", "Is there a region in the image that might be present in organ systems such as the digestive, respiratory, or reproductive system?", "Can you see structures that appear to provide support to organs like the breast, prostate, lung, or colon?", "Does the image contain areas composed of cells such as fibroblasts, immune cells, endothelial cells, or adipocytes?", "Is there evidence of extracellular matrix components like collagen, elastin, fibronectin, or proteoglycans in the tissue?", "Can you identify connective tissue types such as areolar, reticular, or dense irregular connective tissue?", "Is there a region that appears to interact with epithelial tissue by offering structural support or facilitating nutrient exchange?", "Does the image show blood vessels such as capillaries, arterioles, or venules within connective tissue?", "Can you see lymphatic structures like lymphatic capillaries, lymph nodes, or lymphatic vessels associated with the connective tissue?", "Is there a visible boundary or interface between basement membrane and adjacent supportive tissue?"], "contexual_behavior": [], "functions": ["Is there a region in the image that provides structural support to the tissue by forming a scaffold of extracellular matrix and connective tissue cells?", "Can you identify an area that mediates cell signaling or facilitates tissue repair?", "Does the image show a structure that regulates cell growth by secreting growth factors or modulating the microenvironment?", "Is there evidence of fibroblast activation, matrix deposition, or support for re-epithelialization in the tissue?", "Can you see regions where immune cells are being recruited or where antigen presentation might be occurring within the tissue?", "Is there a visible area involved in remodeling the extracellular matrix or coordinating cellular responses for tissue regeneration?", "Does the image contain vascular networks or blood vessels that could provide nutrients to surrounding cells through diffusion?", "Can you identify regions where paracrine signaling or direct cell-matrix interactions with epithelial cells might be taking place?", "Is there a structure responsible for producing and maintaining extracellular matrix components, such as collagen synthesis?", "Can you see evidence of cytokine or chemokine release that could indicate regulation of inflammation or modulation of immune cell activity?", "Is there a region that appears to be remodeling the matrix, promoting angiogenesis, or supporting invasion of abnormal cells, as seen in tumor progression?", "Does the image show an area involved in balancing matrix turnover and regulating cell behavior to maintain tissue homeostasis?", "Can you identify regions where pro-angiogenic factors might be secreted or where new blood vessel formation is supported?", "Is there evidence of signaling molecule secretion or direct cell-cell interactions that modulate communication between different cell types?", "Does the image contain features suggestive of myofibroblast activation or excessive extracellular matrix deposition, as seen in fibrosis?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a structure located within the femur, pelvis, sternum, vertebrae, or ribs?", "Does the image reveal a tissue residing in the medullary cavity of a bone?", "Is there a structure protected by cortical bone or periosteum?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for hematopoiesis?", "Is there a region that serves as a storage site for stem cells?", "Does the image contain a tissue that increases erythropoiesis during anemia?"]}}}
[ { "answer": "left side lesion", "extracted_concepts": [ "left side lesion" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "left side lesion" ], "question": "does this image show left side lesion?" }, { "answer": "no", "extracted_concepts": [ "muscle atrophy", "left side lesion" ], "question": "does good example of muscle atrophy show left side lesion?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "no", "extracted_concepts": [ "nodule" ], "question": "is nodule present?" }, { "answer": "cleft palate", "extracted_concepts": [ "cleft palate" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "cleft palate" ], "question": "is cleft palate present?" }, { "answer": "no", "extracted_concepts": [ "myoma lesion" ], "question": "is myoma lesion present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "cleft palate", "extracted_concepts": [ "cleft palate" ], "question": "what is present?" } ]	["nodule", "muscle atrophy", "cleft palate", "left side lesion", "face", "myoma lesion"]	{"nodule": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a small lesion in the image that measures less than 3 centimeters in diameter?", "Can you identify a structure with a round or oval appearance?", "Does the image show an object whose color is similar to the surrounding tissue or appears pale?", "Is there a structure that could be either soft or firm in consistency?", "Can you see an area that might be solid, cystic, or have mixed density?", "Is there a feature composed of cells, extracellular matrix, or possibly containing fluid or calcifications?", "Does the image contain an object with a smooth or irregular surface texture?", "Can you find a structure with well-defined or ill-defined margins?", "On ultrasound, is there a region that appears hypoechoic, isoechoic, or hyperechoic compared to adjacent tissue?", "On CT imaging, is there a small area with low, intermediate, or high attenuation?", "Can you identify a structure that shows punctate or coarse calcification, or lacks calcification entirely?", "Is there an area that appears avascular, hypovascular, or hypervascular?", "Does the image show a lesion that appears to have grown slowly or has a variable growth rate?", "Can you see a structure with a homogeneous or heterogeneous internal pattern?", "Is there an object that might feel firm, soft, or rubbery if palpated?", "Can you identify a region that could have high water content, such as a cystic area?", "Is there a small structure with low lipid content, unless it appears to be of adipose origin?", "Does the image show an area where protein concentration might be high due to cellular or matrix components?", "Can you see a region whose temperature would likely match that of the surrounding tissue unless there are signs of inflammation?"], "relational": ["Is there a localized mass present within epithelial, connective, or glandular tissue in the image?", "Can you identify a focal lesion associated with organs such as the thyroid, lung, liver, or skin?", "Does the image show a structure situated in regions like the neck, lungs, breast, or subcutaneous tissue?", "Is there an embedded structure adjacent to blood vessels, nerves, or surrounding parenchyma?", "Can you see a mass containing cell types such as epithelial cells, fibroblasts, inflammatory cells, or neoplastic cells?", "Is there a visible structure that appears as a focal lesion within or attached to the surrounding tissue?", "Does the image contain a mass that is part of a larger anatomical structure such as an organ, lobe, or gland?", "Can you identify a structural component that may belong to the endocrine, respiratory, or integumentary system?", "Is there a mass with arteries, veins, lymphatic vessels, or ducts passing near or connected to it?", "Does the image show a localized structure situated in the dermis, subcutaneous layer, parenchyma, or mucosa?"], "contexual_behavior": ["Does the image show a structure that could increase hormone secretion in response to stimulation, as seen in hyperfunctioning endocrine conditions?", "Is there an area that appears to fail in regulating local tissue metabolism, possibly due to disrupted cellular composition or signaling?", "Can you identify a region that might impair organ function by causing local edema, cellular infiltration, or compressing nearby structures?", "Does the image contain a feature that could indicate altered signaling activity, suggestive of malignant transformation or abnormal growth communication?", "Is there evidence of reduced secretory function in a region where fibrosis or increased extracellular matrix deposition has replaced functional cells?", "Can you see a structure with increased vascularization, possibly due to hypoxic conditions and upregulation of angiogenic factors?", "Is there a part of the tissue where normal architecture appears disrupted, potentially due to rapid cellular proliferation outpacing supporting stroma?", "Does the image reveal an area with decreased metabolic activity, which might indicate a response to therapy or reduced cellular viability?", "Can you identify a region showing signs of abnormal cell proliferation, as might occur in pathological or neoplastic processes?", "Is there evidence of loss of homeostasis in a localized area, possibly due to infection and immune cell infiltration?", "Does the image show a site with enhanced local immune response, such as lymphocytic infiltration and cytokine production in autoimmune disease?", "Is there a region where normal tissue function appears suppressed, potentially due to exposure to toxins or necrosis?", "Can you see a structure with altered endocrine activity, possibly resulting from disrupted feedback mechanisms and hormonal imbalance?", "Is there an area that seems unresponsive to regulatory signals, which could be due to chronic disease and desensitized receptors or pathways?", "Does the image reveal increased extracellular matrix production in response to injury, such as activation of fibroblasts and collagen deposition?"], "functions": ["Does the image show a localized mass that could indicate abnormal tissue growth or a response to injury?", "Is there evidence of a structure that disrupts normal tissue architecture or impairs the function of the surrounding tissue?", "Can you identify a region that might be associated with inflammation, fibrosis, or neoplastic transformation?", "Is there a visible area where increased cell proliferation, immune cell recruitment, or extracellular matrix deposition could be occurring?", "Does the image contain a site that could contribute to disease progression, such as persistent inflammation, tumor development, or organ dysfunction?", "Is there a structure that appears to attract immune cells or modulate local immune responses?", "Can you see an area that might compromise organ function by obstructing normal tissue pathways or altering physiological processes?", "Is there a region supporting unchecked cellular proliferation or accumulation of extracellular material, suggesting abnormal tissue growth?", "Does the image show a formation that could signal tissue injury or a repair response to chronic damage?", "Is there a visible feature that might disrupt blood flow, alter secretion, or impede normal tissue interactions at its location?"]}, "no_questions": {"contexual_properties": ["Does the image show a structure that appears enlarged, which could suggest the presence of cysts, ovulation, or a tumor?", "Does the image suggest a decrease in organ weight, as might occur after menopause, surgical removal, or atrophy?", "Can you identify fluid accumulation within or around a structure, as might be seen with cysts, edema, or hyperstimulation syndrome?"], "properties": ["Does the image show a structure that could have a water content of about 70 to 80 percent by weight?", "Does the image contain an object with a temperature similar to core body temperature, around 37 degrees Celsius?", "Can you see a structure that might weigh between 5 and 8 grams in an adult woman?"], "relational": ["Can you identify tissues such as an outer cortex, inner medulla, or a germinal epithelium layer?", "Can you identify an object located in the pelvic cavity?", "Does the image show a structure connected to the uterine tube?"], "contexual_behavior": ["Is there a structure that could have reduced function after exposure to chemotherapy or radiation due to follicular and stromal damage?", "Can you identify a structure that increases estrogen secretion during the phase when follicles are developing?", "Does the image contain something that could exhibit reduced progesterone output due to inadequate corpus luteum function?"], "functions": ["Can you identify a structure where follicle maturation and selection of a dominant follicle occur?", "Does the image contain an object that synthesizes estrogen and progesterone?", "Is there evidence of a structure that forms a corpus luteum after ovulation?"]}}, "muscle atrophy": {"yes_questions": {"contexual_properties": ["Does the image show a region where muscle mass appears reduced compared to surrounding areas?", "Can you identify a muscle that appears visibly thinner than normal?", "Is there evidence of increased fat or connective tissue within a muscle structure?", "Does the image reveal a muscle with decreased cross-sectional area or volume?", "Can you see signs of muscle weakness, such as reduced muscle bulk or loss of tone?", "Is there a muscle that appears paler or has a different color, suggesting replacement by fatty or connective tissue?", "Does the image show muscle fibers that seem shrunken or diminished in size?", "Is there a visible change in muscle texture, such as increased fibrous appearance or loss of normal striations?", "Can you observe a muscle with decreased density, possibly due to loss of contractile proteins?", "Is there evidence of muscle wasting that could be associated with chronic disease, prolonged inactivity, or aging?", "Does the image display a muscle with signs of fibrosis or increased connective tissue content?", "Can you identify a muscle that appears to have lost volume due to replacement by non-muscle tissue?", "Is there a region where muscle tone seems reduced, possibly due to lack of neural stimulation?", "Does the image suggest muscle wasting that could be accelerated by systemic illness or corticosteroid use?", "Can you see any muscle changes that might indicate malnutrition, immobilization, or disuse?"], "properties": ["Can you identify a region where the mass of contractile tissue appears reduced by up to 20% compared to surrounding areas?", "Is there evidence of muscle fibers that appear thinner, with diameters decreased by as much as 30%?", "Does the image show tissue where the cross-sectional area of fibers is visibly reduced by up to 50%?", "Can you see a region where the density of muscle tissue appears lower, possibly due to increased fat content?", "Is there an area where the tissue appears paler or lighter in color than typical healthy muscle?", "Does any region show a softer or less firm texture compared to adjacent muscle tissue?", "Can you identify tissue that might have increased fat or connective tissue infiltration?", "Is there a visible indication of increased collagen or fibrotic tissue within the muscle?", "Does the image suggest a reduction in muscle strength, as might be inferred from decreased muscle bulk?", "Can you see evidence of reduced mitochondrial content, such as a loss of oxidative capacity in the tissue?", "Is there a region where muscle glycogen stores might be depleted, as suggested by changes in tissue appearance?", "Does the image show muscle tissue that could have decreased levels of muscle-specific enzymes like creatine kinase?", "Can you identify an area where the water content appears slightly reduced compared to normal muscle tissue?"], "relational": ["Does the image show a region where skeletal muscle tissue appears reduced or diminished?", "Can you identify any areas in the upper or lower limbs that display signs of decreased muscle mass?", "Is there evidence of changes in the arms or legs that could suggest involvement of the musculoskeletal system?", "Does the image reveal any alterations in structures such as tendons or bones adjacent to muscles?", "Can you observe any features that might indicate impaired neural input, such as changes near peripheral nerves or motor neurons?", "Are there visible differences in the hands or feet that could be associated with reduced muscle bulk?", "Does the image show connective tissue structures like endomysium or perimysium in association with thin or wasted muscles?", "Is there any indication of altered cellular components, such as reduced density of myofibrils or mitochondria, within muscle tissue?", "Can you see any changes in the relationship between muscles and nearby joints or ligaments?", "Does the image suggest involvement of neuromuscular junctions in areas where muscle tissue appears diminished?"], "contexual_behavior": [], "functions": ["Does the image show evidence of decreased muscle mass or impaired muscle function?", "Can you identify signs of reduced muscle strength or limited range of movement?", "Is there any indication of impaired mobility or increased risk of falls?", "Does the image suggest a reduction in basal metabolic rate or protein synthesis due to loss of muscle tissue?", "Can you observe features that might indicate lower overall energy expenditure?", "Is there visual evidence of reduced endurance or impaired ability to perform physical tasks?", "Does the image reveal postural weakness or signs of balance impairment?", "Can you see indications of diminished adaptation to exercise or increased fatigue?", "Is there any sign that recovery from injury or illness might be delayed or functional deficits prolonged?", "Does the image suggest impaired glucose uptake or decreased insulin sensitivity in muscle tissue?", "Can you observe decreased joint stability or muscle weakness supporting the joints?", "Is there any indication of impaired thermoregulation or reduced heat production?", "Does the image show features that might contribute to increased frailty or progression of chronic diseases?"]}, "no_questions": {"contexual_properties": ["Is there evidence of increased fluid accumulation at a site of acute inflammation or infection?", "Is there evidence of increased fibrin content or fibrin deposition, which might be seen in fibrinous inflammation or coagulation activation?", "Is there a clear, watery fluid present that might be associated with mild inflammation or early tissue injury?"], "properties": ["Is there a fluid present that might have a higher protein concentration than typical plasma?", "Does the image show a fluid that is likely close to body temperature, around 37\u00b0C?", "Is there a fluid that could have a low glucose level compared to plasma?"], "relational": ["Can you see any signs of increased permeability in blood vessels or capillaries, such as fluid or cells escaping into surrounding tissues?", "Can you identify organs like the lungs, heart, liver, joints, or skin that appear affected by localized fluid or cellular accumulation?", "Does the image show evidence of fluid accumulation in areas such as the pleural cavity, peritoneal cavity, joint spaces, or alveoli?"], "contexual_behavior": ["Does the image suggest a reduction in fluid accumulation following infection control and resolution of inflammation?", "Is there visible swelling or edema that could be attributed to increased hydrostatic pressure, as seen in congestive heart failure?", "Does the image show evidence of increased fluid accumulation in tissues that might occur during the early stages of acute inflammation?"], "functions": ["Is there a structure that could be providing a medium for immune cell migration or chemotaxis?", "Does the image suggest the presence of a substance that could be reducing tissue viscosity and forming chemotactic gradients for white blood cell migration?", "Is there a feature that might be delivering nutrients such as proteins, glucose, or electrolytes to damaged tissues?"]}}, "cleft palate": {"yes_questions": {"contexual_properties": ["Does the image show a gap or opening in the palate that appears wider than expected for the patient's age, possibly indicating developmental changes or lack of surgical intervention?", "Is there evidence of a narrowed palatal defect that might suggest successful surgical repair or tissue contraction during healing?", "Can you identify areas of swelling or edema in the palatal region that could be due to acute inflammation, infection, or recent trauma?", "Does the image reveal abnormal tissue growth or nodular changes in the palate, which might result from chronic irritation, repeated surgeries, or neoplastic transformation?", "Are there visible color changes in the palatal tissues, such as pallor, redness, or bruising, that could indicate infection, poor blood supply, or hemorrhage?", "Is there any sign of erythema, swelling, or purulent discharge in the palatal area, which may suggest postoperative infection or recent trauma?", "Can you observe areas of increased fibrosis or scarring in the palate, possibly due to repeated surgical interventions or chronic inflammation?", "Does the image show extensive scar tissue or fibrotic changes in the palate that could be the result of multiple surgeries or delayed healing?", "Are there ulcerated regions in the palatal tissue, which might be caused by trauma, infection, or impaired wound healing?", "Is there evidence of active bleeding or blood accumulation in the palatal area, potentially related to recent surgery, trauma, or a bleeding disorder?", "Can you identify a fistula or abnormal connection in the palate that may have developed after failed surgical repair or ongoing tissue breakdown?", "Does the palatal region appear to be healing slowly, with persistent defects or granulation tissue, possibly due to infection, malnutrition, or systemic disease?", "Is there visible fluid accumulation or edema in the palate that could be associated with infection, inflammation, or postoperative complications?", "Does the palatal defect seem more pronounced or larger than expected for the patient's developmental stage, suggesting progression during a growth spurt or lack of repair?", "Are there observable changes in the tissue composition of the palate, such as areas of scar tissue or altered texture, following surgical repair or chronic inflammation?"], "properties": [], "relational": ["Is there a visible abnormal opening at the roof of the mouth involving the anterior or posterior palatal regions?", "Can you identify a disruption in the continuity of the hard or soft palate?", "Does the image show an abnormal communication between the oral and nasal cavities?", "Are the palatal mucosa, muscle, or underlying bone visibly interrupted in the roof of the mouth?", "Is there evidence of involvement of the alveolar ridge in the palatal region?", "Can you see any discontinuity affecting the palatine processes of the maxilla or the horizontal plates of the palatine bones?", "Is there a defect that extends from the area near the incisive foramen to the region of the uvula?", "Are there visible changes in the upper lip or nasal septum that might be associated with a craniofacial anomaly?", "Does the image suggest possible impact on muscles such as the levator veli palatini, tensor veli palatini, or palatoglossus?", "Can you identify a structural abnormality that could influence the function of the digestive, respiratory, or speech systems?"], "contexual_behavior": [], "functions": ["Does the image show a structure that could impair the separation between the oral and nasal cavities, potentially leading to swallowing difficulties?", "Is there evidence of an anatomical feature that might cause nasal regurgitation during feeding or swallowing?", "Can you identify a condition that would disrupt normal speech production, possibly resulting in hypernasality or articulation errors?", "Does the image include a feature that could make it difficult for an infant to generate suction or coordinate swallowing, potentially leading to poor weight gain?", "Is there a visible abnormality that might increase the risk of recurrent ear infections by affecting Eustachian tube function?", "Can you see a structure that would allow food or air to pass between the oral and nasal cavities during eating or speaking?", "Is there an anatomical finding that could alter airflow, allowing air to escape through the nose during speech and reduce speech intelligibility?", "Does the image reveal a disruption in the attachment or function of facial muscles involved in swallowing, speech, or facial expression?", "Is there a feature that could interfere with the regulation of middle ear pressure by affecting the muscles that open the Eustachian tube?", "Can you identify an abnormality that would reduce the effectiveness of preventing food and liquids from entering the nasal cavity during swallowing?", "Does the image show a condition that could cause excessive nasal resonance or difficulty producing certain consonant sounds in speech?"]}, "no_questions": {"contexual_properties": ["Is there increased background staining that might result from inadequate blocking, high antibody concentration, or poor tissue processing?", "Does the image display diffuse staining in regions that could represent uniformly expressing tissues, such as lung or breast adenocarcinoma?", "Are there granular staining patterns that could be due to cytoplasmic aggregation or specific fixation conditions?"], "properties": ["Does the image suggest that heat-induced epitope retrieval with citrate buffer was performed prior to staining?", "Can you infer that the incubation time for the staining procedure was between 30 and 60 minutes at room temperature based on the staining intensity and pattern?", "Can you observe a chromogenic reaction that is likely due to the use of 3,3'-diaminobenzidine (DAB)?"], "relational": ["Can you see areas where the staining could be compared to other cytokeratin stains, such as cytokeratin 20 or cytokeratin 8?", "Does the image include cells from the respiratory, female genital, urinary, or gastrointestinal tracts that are highlighted by a particular stain?", "Is there a staining pattern that helps detect or characterize epithelial tissues based on their cytoskeletal proteins?"], "contexual_behavior": ["Does the staining fail to clearly differentiate between benign and malignant lesions in areas that might be affected by hypoxia?", "Can you identify regions of a carcinoma with diminished staining, suggesting a loss of epithelial differentiation?", "Do you see enhanced staining in tissues that might have been exposed to chemotherapeutic agents, indicating upregulation of the target antigen?"], "functions": ["Is there evidence of a method that supports the identification of metastatic tumors by revealing positive staining in secondary sites?", "Does the image provide visual information that could be used for functional characterization of tumors through assessment of a specific protein marker?", "Is there a staining pattern that could help differentiate between various epithelial tissues?"]}}, "left side lesion": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any abnormality affecting the left thorax, left abdomen, left limbs, or the left side of the head and neck?", "Is there evidence of a pathological change within the left side of any organ system, such as the nervous, musculoskeletal, cardiovascular, respiratory, or digestive system?", "Can you identify a region on the left lateral aspect of the body that appears different from the contralateral side?", "Does the image reveal any disruption or alteration in tissues such as epithelial, muscle, nervous, or connective tissue on the left side?", "Is there a visible abnormality located lateral to the sagittal plane, specifically on the left hemisphere or left lateral aspect?", "Can you see any changes in the left lung, left kidney, left arm, left leg, or the left hemisphere of the brain?", "Does the image show a region on the left side that is defined by the lateral body wall or ipsilateral landmarks?", "Is there any indication of involvement of organs such as the spleen, left ovary, or left testis?", "Can you identify an area within the left hemibody or left anatomical compartments that appears affected?", "Does the image suggest that nerves, blood vessels, muscles, bones, or adjacent organs on the left side are impacted?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a condition that could cause language deficits such as aphasia?", "Is there a visible abnormality that might result in weakness or paralysis on the right side of the body?", "Can you identify a region that, if damaged, would likely cause impaired analytical reasoning or verbal memory?", "Does the image contain signs of an area that could lead to decreased sensation or numbness on the right side?", "Is there a lesion present that might compromise coordination or fine motor skills on the right side?", "Can you see involvement of a brain region associated with speech production or fluency deficits?", "Is there evidence of damage to an area that could impair comprehension of spoken or written language?", "Does the image suggest a lesion that might be linked to behavioral changes such as depression or apathy?", "Is there a region affected that could result in emotional dysregulation or mood disturbances?", "Can you identify a structural abnormality that might cause verbal memory loss or short-term memory deficits?", "Does the image show a lesion that could lead to right-sided visual field loss?", "Is there evidence of a brain region affected that could reduce problem-solving abilities or executive function?", "Can you see a lesion that might hinder independence in daily living activities due to combined language, motor, or cognitive impairments?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a visible organ composed of a cortex, medulla, and a connective tissue capsule?", "Is there a structure supported or surrounded by the pericardium, sternum, pleura, or great vessels?", "Is there an object that receives blood supply from arteries such as the inferior thyroid or internal thoracic artery?"], "contexual_behavior": ["Is there an organ present that may exhibit reduced function or atrophy in response to chronic stress or elevated glucocorticoids?", "Does the image contain an organ whose function might be impaired in cases of congenital immunodeficiency or severe infection?", "Can you identify an organ that decreases its activity and output of mature T cells after puberty?"], "functions": ["Is there a structure present that facilitates the selection of thymocytes based on their response to self-antigens?", "Does the image contain an organ responsible for eliminating T cells that strongly react to self-antigens?", "Can you identify an organ that generates a diverse repertoire of T cells for adaptive immunity?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image suggest developmental variation in the size of the central skull base opening, such as differences between infants and adults?", "Can you identify an oval or elliptical structure at the skull base?", "Can you see an opening with a circumference of about 100 millimeters?"], "relational": ["Does the image include a feature adjacent to the clivus or jugular tubercles?", "Is there a structure located in the posterior cranial fossa of the skull?", "Is there an opening through which spinal accessory nerves and meninges traverse?"], "contexual_behavior": ["Is there any indication of cerebellar tonsillar herniation through an opening at the skull base, suggesting impaired cerebrospinal fluid flow?", "Does the image show evidence of neural compression at the craniovertebral junction, as might occur in congenital malformations?", "Is there any abnormality in the size or shape of the opening at the skull base that could indicate a growth disorder or altered skeletal development?"], "functions": ["Can you identify an opening that facilitates cerebrospinal fluid flow between the cranial and spinal subarachnoid spaces?", "Is there an anatomical feature that physically links the intracranial and spinal neural compartments, supporting central nervous system connectivity?", "Can you see a structure that allows the vertebral arteries and accessory nerve to pass between the cranial and spinal compartments?"]}}, "myoma lesion": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure associated with the female reproductive system?", "Is there a lesion involving smooth muscle or connective tissue visible in the image?", "Can you identify an abnormality located in the uterus or cervix?", "Does the image display a mass adjacent to the endometrium, myometrium, or serosa?", "Is there a lesion present within the submucosal, intramural, or subserosal layers of the uterus?", "Can you see a structure that appears to receive blood supply from the uterine or ovarian artery?", "Is there evidence of an abnormality altering the structure of the uterine wall?", "Does the image contain a mass composed of smooth muscle cells or fibroblasts?", "Is there a lesion affecting the uterine corpus or fundus?", "Can you observe any displacement or compression of the bladder, rectum, or uterine cavity by a mass?"], "contexual_behavior": ["Does the image show a lesion whose growth rate might be higher during the reproductive years and lower after menopause?", "Is there a structure present that could impair uterine contractility during menstruation by interfering with myometrial function?", "Can you identify a lesion that may alter its vascularization or show increased angiogenesis during pregnancy?", "Does the image contain a mass that could decrease in metabolic activity following hormonal therapy with GnRH agonists?", "Is there evidence of a structure that might increase extracellular matrix production in response to estrogen stimulation?", "Can you see a lesion that could distort the uterine cavity and disrupt normal endometrial function during the menstrual cycle?", "Is there a mass that may reduce its ability to promote angiogenesis after menopause due to lower estrogen levels?", "Does the image show a lesion that could increase inflammatory signaling and local cytokine release during tissue injury or degeneration?", "Can you identify a structure that might impair fertility by altering the uterine environment or distorting the endometrial cavity?", "Is there a lesion that could increase its secretion of growth factors in response to progesterone, supporting cellular proliferation?", "Does the image show a mass whose proliferation might be reduced after treatment with GnRH agonists?", "Can you see a lesion that could alter uterine blood flow during pregnancy due to increased vascular demand and hormonal changes?", "Is there evidence of a structure that might increase fibrotic activity and collagen deposition under chronic inflammation?", "Does the image contain a lesion whose functional impact could decrease after surgical intervention such as myomectomy or ablation?"], "functions": ["Does the image show a benign growth within the uterus that could disrupt normal smooth muscle architecture?", "Is there evidence of a uterine mass that might impair contractility of the uterine wall?", "Can you identify a lesion that could be responsible for abnormal or heavy menstrual bleeding?", "Does the image contain a structure that might distort the uterine cavity and potentially interfere with embryo implantation?", "Is there a mass present that could alter the uterus's responsiveness to estrogen or progesterone?", "Can you see a lesion that might cause pelvic pain or exert pressure on nearby pelvic organs?", "Is there a structure that could disrupt normal endometrial function or cause local inflammation?", "Does the image show a mass that might affect the vascular supply of the uterus, such as by compressing blood vessels or promoting abnormal angiogenesis?", "Can you identify a lesion interacting with adjacent uterine tissues by compressing or displacing the myometrium or endometrium?", "Is there evidence of abnormal uterine growth due to proliferation of smooth muscle cells and extracellular matrix?"]}, "no_questions": {"contexual_properties": ["Can you identify areas where cellular proliferation appears reduced, as might be seen in late pregnancy or placental insufficiency?", "Are there areas where tissue density appears altered, potentially reflecting hyperplasia or neoplastic transformation?", "Are there regions where tissue proliferation appears insufficient, as might occur in placental insufficiency or fetal growth restriction?"], "properties": ["Does the image contain any abnormal growth or expansion of the chorionic surface layer?", "Can you identify regions where the surface layer of the chorion appears thicker than usual?", "Does the image show evidence of increased cell numbers in the outermost fetal membrane?"], "relational": ["Does the image contain layers such as cytotrophoblast and syncytiotrophoblast?", "Does the image include vascular features like chorionic villi or fetal capillaries?", "Can you see a region composed of cytotrophoblasts and syncytiotrophoblasts?"], "contexual_behavior": ["Does the image show evidence of increased cellular activity in the outermost fetal membrane?", "Can you identify regions where the epithelial layer of the chorion appears thicker or denser than usual?", "Is there a visible indication of abnormal growth or expansion in the tissue covering the fetal side of the placenta?"], "functions": ["Does the image suggest an increased number of cells involved in nutrient transfer between maternal and fetal compartments?", "Is there a robust barrier apparent that might limit immune cell infiltration and help protect the fetus from maternal immune responses?", "Is there a region where efficient nutrient or gas exchange between mother and fetus is likely occurring due to expanded placental surface?"]}}}
[ { "answer": "cephalohematoma", "extracted_concepts": [ "cephalohematoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "cephalohematoma" ], "question": "is cephalohematoma present?" }, { "answer": "no", "extracted_concepts": [ "cytomegaly" ], "question": "is cytomegaly present?" }, { "answer": "cephalohematoma", "extracted_concepts": [ "cephalohematoma" ], "question": "what is present?" } ]	["cephalohematoma", "cytomegaly"]	{"cephalohematoma": {"yes_questions": {"contexual_properties": ["Is there a swelling that appears to have increased in size shortly after birth, suggesting ongoing hemorrhage beneath the periosteum?", "Can you identify a mass that appears to be gradually decreasing in size, consistent with blood resorption over days to weeks?", "Is there a lesion whose color changes from red to yellow or green, indicating hemoglobin breakdown and bilirubin formation?", "Does the image show a mass that has become firmer, possibly due to clot organization and formation during the subacute phase?", "Can you see an area that appears softer or more fluctuant, which may indicate clot liquefaction or ongoing blood resorption?", "Is there evidence of calcification within a swelling, suggesting chronicity and incomplete blood resorption?", "Does the image reveal signs of infection such as redness, swelling, or pus over a localized mass?", "Can you observe overlying skin changes like erythema or ulceration that might result from infection or pressure necrosis?", "Is there a fluctuant mass present, possibly due to enzymatic breakdown of a clot and partial liquefaction?", "Does the image suggest a spontaneously resolving swelling, consistent with gradual blood reabsorption over several weeks?", "Is there a persistent mass that has not resolved within the expected timeframe, possibly due to calcification, ongoing bleeding, or impaired resorption?", "Can you identify a swelling with multiple lobes or irregular borders, which may indicate extension along suture lines or multilobulated hematoma?", "Is there a mass that appears to have increased in size following birth trauma, suggesting continued bleeding?", "Does the image show signs of neonatal jaundice that could be associated with the breakdown of red blood cells in a localized swelling?"], "properties": ["Is there a dome-shaped or ovoid swelling visible over the parietal region of the skull?", "Can you identify a bluish or purplish area beneath the periosteum of the parietal bone?", "Does the image show a soft, fluctuant swelling that could measure between 2 and 10 centimeters in diameter?", "Is there evidence of a subperiosteal accumulation that might contain clotted blood and plasma?", "Can you see a swelling whose size suggests a volume between 10 and 50 milliliters?", "Is there a structure present that would be expected to resolve within 2 to 6 weeks after birth?", "Does the image show a lesion whose density and water content are similar to those of blood?", "Is there a swelling that would likely have a temperature matching normal body temperature, around 36\u201337\u00b0C?", "Can you identify a structure that would be expected to have a high red blood cell concentration and low white blood cell count unless infected?", "Is there a swelling whose protein content would be similar to that of plasma, approximately 60\u201380 grams per liter?", "Does the image show a lesion located beneath the periosteum and confined to the parietal bone?"], "relational": ["Is there a swelling located between the periosteum and the skull bone, but not involving the more superficial layers of the scalp?", "Can you identify a collection that is limited by the margins of a single cranial bone, such as the parietal bone?", "Does the image show a subperiosteal accumulation that does not cross cranial bone sutures?", "Is there evidence of a lesion that is contained by the periosteum and does not extend beyond the boundaries of an individual cranial bone?", "Can you see a swelling that is most prominent over the parietal region of the skull?", "Is there a feature that could result from rupture of small blood vessels crossing the periosteum, such as emissary veins?", "Does the image show a scalp swelling that is anatomically distinct from more superficial conditions like caput succedaneum?", "Is there a collection located in the subperiosteal space of the scalp?", "Can you identify a swelling that is structurally related to, but distinct from, subgaleal hematoma or caput succedaneum?"], "contexual_behavior": ["Does the image show a scalp swelling that appears unusually large or tense, which might suggest delayed blood reabsorption or impaired scalp mobility?", "Is there evidence of skin breakdown or recent invasive procedures over a scalp swelling, indicating an increased risk of infection?", "Can you identify persistent swelling or signs of infection in the scalp area that could impair normal tissue healing?", "Does the image suggest the presence of jaundice in a newborn, possibly related to the breakdown of accumulated blood in a scalp swelling?", "Is there a scalp swelling that does not appear to be decreasing in size, which might indicate ongoing bleeding, infection, or impaired resorption?", "Can you see a scalp mass large enough to potentially compress surrounding blood vessels or tissues, suggesting interference with local blood circulation?", "Does the image show an extensive scalp swelling or associated cranial injuries that could contribute to increased intracranial pressure?", "Are there visual cues suggesting a bleeding or clotting disorder in the newborn, which could alter the absorption rate of a scalp hematoma?", "Is the newborn premature, with a scalp swelling that appears to be resolving slowly, possibly due to immature metabolic or resorptive processes?", "Does the image show a scalp swelling that has persisted for several weeks, raising the risk of calcification due to delayed resolution?", "Is there a scalp mass that appears to restrict movement or flexibility of the overlying scalp, possibly due to its size, tension, or underlying fibrosis?", "Can you identify signs of local inflammation, such as redness or swelling, in the area of a scalp hematoma, which might be due to infection or repeated trauma?", "Is there evidence that the underlying bone may be at risk for infection, such as an infected scalp hematoma or compromised overlying skin?", "Does the newborn appear anemic, possibly as a result of significant blood loss into a large scalp swelling?", "Are there indications of secondary trauma or rebleeding in the area of a scalp hematoma, which could alter the normal healing process?"], "functions": ["Does the image show a region of localized swelling that could indicate disruption of blood circulation beneath the scalp?", "Is there evidence of a collection between the periosteum and skull that might cause local pressure?", "Can you identify an area where inflammation, such as leukocyte infiltration, may be present at a site of injury?", "Does the image suggest delayed healing or impaired tissue repair in the scalp region?", "Is there a visible feature that could be associated with increased risk of anemia or jaundice in a newborn?", "Can you see any signs that might indicate elevated bilirubin levels due to red blood cell breakdown?", "Is there evidence of calcification or abnormal calcium deposition within a scalp lesion?", "Does the image show a region where clot resolution or fibrinolytic activity might be occurring?", "Can you identify an area where phagocytosis or tissue remodeling processes may be active?", "Is there a visible space that could increase the risk of bacterial growth or infection?", "Does the image suggest activation of fibroblasts or deposition of extracellular matrix in a healing scalp lesion?", "Can you see any signs of tenderness or restricted movement in the scalp tissues that could indicate functional impairment?"]}, "no_questions": {"contexual_properties": ["Is there evidence of thickening or rigidity in the lining that covers the abdominal organs?", "Does the image show any loss of the normal smoothness of the peritoneal cavity due to nodules, fibrosis, or inflammation?", "Is there visual evidence suggesting increased vascular permeability or lymphatic obstruction, such as excessive fluid accumulation?"], "properties": ["Do the tumor cells show features consistent with abnormal chromosomal content, such as aneuploidy?", "Are there structures that seem to have a firm or hard consistency?", "Do the lesions appear to be of moderate to high grade, suggesting poor differentiation?"], "relational": ["Is there evidence of disease affecting organs such as the ovaries, stomach, colon, liver, or small intestine?", "Does the image reveal changes associated with the parietal or visceral peritoneum?", "Does the image show abnormal findings in the abdominal or pelvic cavity?"], "contexual_behavior": ["Can you detect any features that might indicate delayed healing or surgical complications in the peritoneum, such as persistent defects or abnormal tissue regeneration?", "Are there visual cues suggesting changes in the cytokine environment, such as altered cellular composition or tissue appearance in the peritoneum?", "Can you observe any signs of ascites formation, such as free fluid in the abdomen, that could result from increased vascular permeability or impaired lymphatic drainage?"], "functions": ["Are there indications of mechanical compression or obstruction affecting abdominal organs?", "Is there evidence of bowel obstruction, mucosal infiltration, or malabsorption that could impact nutrient absorption?", "Is there evidence of local inflammatory processes, such as cytokine production or recruitment of inflammatory cells?"]}}, "cytomegaly": {"yes_questions": {"contexual_properties": ["Does the image show cells that appear enlarged compared to their neighbors, suggesting a pathological process?", "Can you identify cells with increased volume, possibly due to intracellular accumulation or viral replication?", "Are there cells with altered shapes, such as swelling or irregular outlines, that might indicate cytoskeletal disruption?", "Does the image contain cells with noticeably more cytoplasm, suggesting enhanced synthesis or impaired clearance of cytoplasmic components?", "Can you see cells with enlarged or abnormal nuclei, possibly due to increased nuclear material or the presence of viral inclusions?", "Are there cells whose staining properties differ from surrounding cells, indicating changes in cytoplasmic or nuclear composition?", "Does the image reveal cells with abnormal structural features, such as disrupted architecture or inclusion body formation?", "Can you identify visible inclusion bodies within cells, which may be a result of viral infection or protein aggregation?", "Are there cells that appear swollen under the microscope, consistent with marked cellular enlargement?", "Does the tissue in the image appear enlarged or denser than normal, suggesting accumulation of many affected cells?", "Can you observe changes in tissue density that might result from the presence of enlarged cells?", "Are there cells with altered membrane appearance, such as irregular or disrupted cell borders, possibly due to swelling or viral effects?", "Does the image show multinucleated cells, which could result from cell fusion or abnormal mitosis?", "Can you identify cells with abnormal accumulation of proteins or organelles, indicating altered cellular composition?", "Are there cells with increased cytoplasmic granularity, possibly due to the formation of cytoplasmic inclusions or aggregates?"], "properties": ["Does the image show any cells that are markedly larger than their neighbors, potentially exceeding two to three times the typical cell diameter?", "Can you identify any cells with diameters in the range of 20 to 40 micrometers or greater?", "Is there evidence of cells with volumes surpassing 4000 cubic micrometers?", "Are there cells with enlarged, round to oval nuclei that contain prominent inclusions?", "Do you observe any cells with abundant, basophilic cytoplasm that might contain viral inclusions?", "Is there a cell where the cytoplasm appears disproportionately expanded compared to the nucleus, resulting in a decreased nuclear-to-cytoplasmic ratio?", "Can you see cells that display a dense basophilic or amphophilic staining pattern?", "Are there cells with cytoplasm that appears granular or shows signs of vacuolation?", "Do any nuclei exhibit chromatin that is marginated or clumped, possibly with a clear 'halo' around inclusions?", "Can you identify cells with one to three prominent nucleoli within an enlarged nucleus?"], "relational": ["Does the image show evidence of abnormal enlargement in cells within epithelial, connective, or nervous tissue?", "Can you identify any cells, such as epithelial or endothelial cells, that appear larger than normal?", "Is there a region in the liver, kidney, brain, or lung where cells seem unusually enlarged?", "Does the image display changes in the size of cellular components like the nucleus or cytoplasm?", "Can you observe alterations in the cellular membrane that might indicate abnormal cell growth?", "Is there a visible impact on systems such as the nervous, hepatic, renal, or respiratory systems due to enlarged cells?", "Does the image suggest an abnormal increase in cell or nuclear size that disrupts normal cellular architecture?", "Are there signs of cell enlargement in the central nervous system, liver, kidneys, or lungs?", "Can you see microscopic structures, such as the nucleus or organelles, that appear enlarged or distorted?", "Is there evidence of pathological processes like viral infection, inflammation, or neoplasia that could be associated with enlarged cells?", "Do any histological layers, such as the epithelial, endothelial, or parenchymal layers, show signs of abnormal cell size?"], "contexual_behavior": [], "functions": ["Does the image show cells with abnormal enlargement or altered morphology?", "Can you identify areas where cellular size appears increased compared to normal tissue?", "Is there evidence of disrupted tissue architecture or impaired intercellular communication?", "Does the image suggest functional impairment or organ dysfunction due to changes in cell size?", "Are there visual signs of pathological remodeling or cellular stress within the tissue?", "Can you observe features that might indicate altered energy utilization or changes in biosynthetic activity at the cellular level?", "Is there a reduction in cell proliferation or an increase in apoptotic cells visible in the image?", "Does the tissue display signs of inflammation or damage that could be linked to abnormal cell enlargement?", "Are there indications of disrupted signal transduction or altered receptor function in the cells present?", "Can you see evidence of modified antigen presentation or changes in immune cell activation within the tissue?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a visible junction where the ileum meets a larger tubular structure, possibly involving the ileocecal valve?", "Does the image show a wall composed of multiple layers such as mucosa, submucosa, muscularis propria, and serosa?", "Is there evidence of innervation by the enteric nervous system or by fibers from the vagus or pelvic splanchnic nerves in any visible structure?"], "contexual_behavior": [], "functions": ["Is there a region where undigested carbohydrates might be fermented by anaerobic bacteria?", "Is there a visible area where vitamins like vitamin K and B vitamins could be absorbed after being synthesized by resident bacteria?", "Does the image show a structure that propels fecal matter toward the rectum for excretion?"]}}}
[ { "answer": "inner table prostate primary", "extracted_concepts": [ "metastatic lesion", "skull cap", "inner table", "prostate primary" ], "question": "where does this image show skull cap with obvious metastatic lesion seen on?" }, { "answer": "skull cap with obvious metastatic lesion seen on inner table prostate primary", "extracted_concepts": [ "metastatic lesion", "skull cap", "inner table", "prostate primary" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "obvious metastatic lesion", "skull cap", "inner table", "prostate primary" ], "question": "does this image show skull cap with obvious metastatic lesion seen on inner table prostate primary?" }, { "answer": "no", "extracted_concepts": [ "obvious metastatic lesion", "skull cap", "inner table", "prostate primary" ], "question": "does yo show skull cap with obvious metastatic lesion seen on inner table prostate primary?" }, { "answer": "metastatic carcinoma", "extracted_concepts": [ "metastatic carcinoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "metastatic carcinoma" ], "question": "is metastatic carcinoma present?" }, { "answer": "no", "extracted_concepts": [ "ear lobe horizontal crease" ], "question": "is ear lobe horizontal crease present?" }, { "answer": "skull cap with obvious metastatic lesion", "extracted_concepts": [ "skull cap", "obvious metastatic lesion", "inner table", "prostate primary" ], "question": "what seen on inner table prostate primary?" }, { "answer": "on inner table prostate primary", "extracted_concepts": [ "obvious metastatic lesion", "skull cap", "inner table", "prostate primary" ], "question": "what is skull cap with obvious metastatic lesion seen?" }, { "answer": "metastatic carcinoma", "extracted_concepts": [ "metastatic carcinoma" ], "question": "what is present?" }, { "answer": "inner", "extracted_concepts": [ "table prostate primary", "obvious metastatic lesion", "skull cap" ], "question": "how is skull cap with obvious metastatic lesion seen on table prostate primary?" }, { "answer": "primary", "extracted_concepts": [ "obvious metastatic lesion", "primary", "inner table", "prostate", "skull cap" ], "question": "how is skull cap with obvious metastatic lesion seen on inner table prostate?" } ]	["table prostate primary", "obvious metastatic lesion", "primary", "metastatic carcinoma", "metastatic lesion", "inner table", "prostate", "ear lobe horizontal crease", "skull cap", "prostate primary"]	{"table prostate primary": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears enlarged, which could suggest benign prostatic hyperplasia or malignancy?", "Can you identify an object that seems reduced in size, possibly due to androgen deprivation therapy or age-related atrophy?", "Does the image show a structure with increased weight or mass, potentially indicating pathological growth or inflammation?", "Is there an area that appears firmer than surrounding tissue, which might be associated with malignancy, fibrosis, or chronic inflammation?", "Can you see a region that looks softer, possibly due to acute inflammation or tissue necrosis?", "Is there evidence of color changes within a structure, such as those caused by hemorrhage, necrosis, or infection?", "Does the image reveal nodular formations that could be linked to benign prostatic hyperplasia or cancer?", "Is there a structure that might be associated with elevated PSA levels due to malignancy, inflammation, or hyperplasia?", "Can you identify areas with calcifications, which may be related to aging or chronic inflammation?", "Is there visible asymmetry in a structure, possibly resulting from tumors or nodular hyperplasia?", "Does the image show abnormal tissue composition, such as that seen in cancer, chronic inflammation, or fibrosis?", "Can you detect cystic regions that might result from ductal obstruction, inflammation, or congenital anomalies?", "Is there evidence of inflammation, such as swelling or redness, that could indicate prostatitis or infection?", "Does the structure display increased vascularity, which may be present in malignancy or acute inflammation?", "Is there a loss of normal glandular architecture, as might occur in advanced cancer or severe fibrosis?", "Can you see areas of increased density, potentially due to fibrosis or tumor infiltration?", "Is there visible edema, such as swelling, that could be caused by acute inflammation or infection?", "Does the image show fibrotic changes, possibly following chronic inflammation or injury?", "Can you observe alterations in texture, such as nodularity, fibrosis, or edema, within the structure?", "Is there evidence of increased cellularity, which could be associated with hyperplasia or malignancy?"], "properties": ["Does the image show a structure with dimensions approximately 3 to 4 cm wide, 4 to 5 cm long, and 2 to 3 cm deep?", "Is there an object present that would weigh about 20 to 30 grams in an adult male?", "Can you identify a structure that appears chestnut-shaped or conical?", "Does the image contain something with a pale grayish or light reddish-brown appearance?", "Is there a structure whose volume would be around 20 to 30 milliliters in an adult male?", "Can you see an object composed of glandular tissue, fibromuscular stroma, and connective tissue?", "Does the image show a structure likely to contain secretory epithelial cells, basal cells, neuroendocrine cells, and stromal cells?", "Is there an object with a density close to 1.05 grams per cubic centimeter?", "Can you identify a structure that would have a water content of approximately 70 to 80 percent by weight?", "Does the image show something with a firm and rubbery texture?", "Is there a structure that would produce a fluid with a slightly acidic pH, around 6.4 to 7.0?", "Can you see an object whose protein content is about 20 to 25 percent of its wet weight?", "Does the image contain a structure with a lipid content of approximately 2 to 4 percent of its wet weight?", "Is there an object that contains minerals such as zinc, calcium, magnesium, and phosphorus?", "Can you identify a structure estimated to have between 30 and 50 glandular units?"], "relational": ["Does the image show a structure that is part of the male reproductive system?", "Can you identify an organ located within the pelvic region?", "Is there a structure situated inferior to the urinary bladder and surrounding its neck?", "Does the image contain an object adjacent to both the rectum and the seminal vesicles?", "Can you see a structure that encircles the proximal portion of the urethra, forming a specialized segment?", "Is there evidence of ducts such as the prostatic urethra or ejaculatory ducts connected to a visible organ?", "Does the image show a structure that receives blood supply from branches of the internal iliac artery or the inferior vesical artery?", "Can you identify an organ composed of glandular tissue, fibromuscular stroma, and connective tissue?", "Is there a structure associated with both the seminal vesicles and bulbourethral glands?", "Does the image reveal anatomical layers such as a capsule, peripheral zone, central zone, or transitional zone within a visible organ?"], "contexual_behavior": ["Does the image show a structure whose secretory activity might decrease with advancing age or chronic disease?", "Can you identify a gland that could exhibit impaired function if its tissue is compressed by hyperplastic nodules, as seen in benign prostatic hyperplasia?", "Is there an organ that might increase its secretory activity in response to elevated androgen levels, such as during puberty or hormonal stimulation?", "Does the image contain a structure that could fail to contribute to semen liquefaction in the presence of severe glandular dysfunction or advanced disease?", "Can you see an organ whose function may decline due to persistent inflammation damaging its glandular tissue, as in chronic prostatitis?", "Is there a gland that could alter its secretory profile due to malignant transformation, such as during cancer development?", "Does the image show a structure whose ability to protect sperm might be reduced under inflammatory conditions?", "Can you identify an organ whose enzymatic activity could change with aging due to reduced androgen levels and cellular senescence?", "Is there a gland that might increase its secretion of a specific antigen in response to inflammation, benign hyperplasia, or malignancy?", "Does the image contain a structure whose function could become impaired after therapy that deprives it of androgens?", "Can you see an organ whose contribution to fertility might decrease in the context of metabolic and hormonal dysregulation, such as metabolic syndrome?", "Is there a gland that could alter its behavior during acute infection by increasing inflammatory mediator production and reducing normal secretion?", "Does the image show a structure that might exhibit reduced function following radiation therapy due to tissue damage?", "Can you identify an organ that increases inflammatory mediator production as part of the immune response to infection?", "Is there a gland whose secretory function could improve after successful treatment for infection and recovery of glandular tissue?"], "functions": ["Does the image show a structure involved in male reproductive function or urinary regulation?", "Is there an object present that produces components of seminal fluid to support sperm?", "Can you identify a gland that adds fluid to semen to enhance sperm motility and fertility?", "Does the image contain a structure that surrounds the proximal urethra and helps control urine flow?", "Is there evidence of a gland that participates in hormone metabolism by converting testosterone to dihydrotestosterone?", "Can you see a structure that secretes enzymes and nutrients to activate and nourish sperm?", "Is there an object that produces secretions such as PSA, citric acid, or zinc to liquefy semen and protect sperm?", "Does the image include a gland that interacts with seminal vesicles or bulbourethral glands to coordinate seminal fluid composition?", "Can you identify a structure that secretes alkaline fluid to buffer semen against acidic environments?", "Is there a gland visible that contracts during ejaculation to expel fluid into the urethra?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify an area that would be expected to have a mildly acidic pH, between 4.5 and 5.5?", "Is there an area that could be composed of cell types such as keratinocytes, melanocytes, myoepithelial cells, or ductal epithelial cells?", "Is there a surface that appears slightly rough or wrinkled, possibly due to small papillae and multiple openings?"], "relational": ["Does the image contain a structure composed of stratified squamous epithelium and smooth muscle?", "Is there an object positioned on the anterior thoracic region of the body?", "Is there a structure likely innervated by the fourth intercostal nerve?"], "contexual_behavior": [], "functions": ["Does the image include a region involved in transmitting sensory signals that contribute to sexual arousal?", "Can you identify an area that provides tactile or olfactory cues important for infant feeding behavior?", "Can you see a region likely to contain dense sensory nerve endings for detecting touch or temperature?"]}}, "obvious metastatic lesion": {"yes_questions": {"contexual_properties": ["Does the image show any abnormal area that could indicate the spread of disease from another primary site?", "Can you identify a region that appears distinct from surrounding tissue and may suggest secondary involvement by a pathological process?", "Is there a visible lesion that differs in appearance from normal tissue and could represent a distant manifestation of a primary condition elsewhere in the body?"], "properties": [], "relational": ["Does the image show an abnormality within the skeletal, respiratory, hepatic, or nervous systems?", "Can you identify a lesion in the bone, liver parenchyma, lung parenchyma, brain tissue, or lymph nodes?", "Is there a region in the image that could be associated with secondary involvement from cancers such as breast, lung, prostate, colorectal carcinoma, or melanoma?", "Does the image contain a structure located in the liver, lungs, brain, bones, or lymph nodes that appears abnormal?", "Can you see an area adjacent to normal parenchyma, blood vessels, connective tissue, or nerves that appears disrupted or infiltrative?", "Is there evidence of lymphatic involvement, such as lymph node infiltration or lymphovascular invasion, in the image?", "Does the image suggest the presence of a lesion that may have spread via the circulatory or lymphatic systems?", "Can you identify a mass or lesion that appears to have formed through hematogenous or lymphatic spread, or by direct extension?", "Is there a region where malignant tumor cells might be present, possibly accompanied by stromal, inflammatory, or endothelial cells?"], "contexual_behavior": ["Does the image show an area that could represent abnormal tissue growth distinct from surrounding structures?", "Is there a region that appears different in texture or color compared to adjacent tissues, suggesting a pathological process?", "Can you identify a lesion that is visually distinct and may indicate the presence of disease spread from another location?", "Does the image contain any structures that look atypical or out of place relative to normal anatomy?"], "functions": ["Does the image show a region where normal tissue architecture appears distorted or replaced by abnormal growth?", "Is there evidence of a structure that could be causing local destruction or compromising the integrity of an organ?", "Can you identify an area that might be interfering with normal physiological activities of the surrounding tissue?", "Is there a visible mass that could represent a secondary site of tumor growth, distinct from the primary lesion?", "Does the image contain features suggestive of new blood vessel formation or abnormal vascular patterns?", "Is there a region that appears to be undergoing rapid cell proliferation or expansion?", "Can you see signs of tissue invasion into areas that are normally separate or protected?", "Is there evidence of hypoxic regions or possible hemorrhage associated with abnormal tissue?", "Does the image suggest the presence of a lesion that could be modulating the local immune environment, such as by altering immune cell infiltration?", "Is there a structure that might be modifying the extracellular matrix or secreting factors to support its own growth?", "Can you identify an area that could be involved in the dissemination of malignant cells to distant sites?", "Is there a region that appears resistant to therapy, such as persisting despite signs of treatment or showing features of survival advantage?", "Does the image show any signs of architectural distortion that could indicate functional impairment of the affected organ?", "Is there evidence of vascular remodeling or abnormal blood vessel arrangement in association with a suspicious lesion?", "Can you see features that might indicate the activation of abnormal signaling pathways within a mass or lesion?"]}, "no_questions": {"contexual_properties": ["Is there a vertebral structure with bony changes that might result from chronic stress, osteoarthritis, or a previous fracture?", "Is there loss of normal curvature in the upper cervical spine that could indicate chronic misalignment or muscular imbalance?", "Does the image reveal swelling or edema around a cervical vertebra following injury?"], "properties": ["Does the image reveal any irregular spacing or positioning near the atlas vertebra?", "Does the image show any abnormal alignment involving the first cervical vertebra?", "Can you identify any displacement at the junction between the skull and the cervical spine?"], "relational": ["Can you see any indication of vascular structures, such as vertebral arteries, being impinged in the cervical region?", "Is there evidence of instability or abnormal spacing at the atlanto-occipital joint?", "Does the image suggest possible compromise of neural structures near the upper cervical spine?"], "contexual_behavior": ["Can you observe any irregular spacing or positioning involving the uppermost cervical vertebra?", "Is there evidence of partial displacement at the junction between the head and the cervical spine?", "Does the image show any abnormal alignment between the first cervical vertebra and the skull?"], "functions": ["Is there evidence of abnormal muscle tone or impaired coordination in the neck region that could be due to altered neural signaling?", "Can you identify any signs that suggest compression or irritation of the spinal cord or adjacent nerve roots in the upper cervical region?", "Is there a visible reduction in the range of neck rotation or flexion-extension movements?"]}}, "primary": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears enlarged, possibly due to growth, inflammation, or tumor formation?", "Can you identify an area that looks reduced in size, suggesting atrophy, degeneration, or tissue loss?", "Does the image show a region with color changes that might indicate hemorrhage, necrosis, or a pigmentation disorder?", "Is there an object that appears heavier or denser, potentially due to fluid accumulation, increased cell numbers, or infiltration by abnormal substances?", "Can you see a structure that seems lighter or reduced in mass, which could be due to atrophy, dehydration, or necrosis?", "Is there evidence of altered tissue composition, such as changes from metabolic processes, infiltration by foreign cells, or fibrosis?", "Does the image reveal abnormal structural features that could be associated with dysplasia, neoplasia, or congenital malformations?", "Is there a region that appears swollen, possibly as a result of inflammation, edema, or infection?", "Can you identify an area that looks shrunken, which might be due to atrophy, fibrosis, or the resolution of previous swelling?", "Does the image show changes in density, such as increased calcification, fat infiltration, or fluid accumulation?", "Is there evidence of abnormal material buildup, like amyloid deposits, fat accumulation, or iron overload?", "Can you see signs of cellular changes, such as increased cell numbers, transformation of cell type, or cell death?", "Is there a region that appears fibrotic, possibly due to chronic inflammation, injury, or fibrotic disease?", "Does the image display unusual surface features, such as ulcers, nodules, or papillomatous growths?", "Is there a structure that shows abnormal measurable levels, which could indicate dysfunction, disease progression, or metabolic imbalance?"], "properties": ["Does the image show any structures that are approximately 10 to 100 micrometers in diameter?", "Can you identify an object whose weight might be in the nanogram or picogram range?", "Is there a structure present that appears spherical or ovoid in shape?", "Do you see any objects that are transparent or slightly off-white when unstained?", "Is there evidence of a structure composed of water, proteins, lipids, carbohydrates, nucleic acids, and minerals?", "Can you identify an object with a density close to 1.05 to 1.10 grams per cubic centimeter?", "Does the image include a structure likely to maintain a neutral to slightly alkaline pH between 7.0 and 7.4?", "Is there an object that could contain about 70% water by weight?", "Can you see a structure where proteins might make up 10% to 20% of its mass?", "Is there evidence of an object with a lipid content of approximately 2% to 5%?", "Does the image show a structure that could have 1% to 3% carbohydrate content?", "Can you identify an object where nucleic acids might constitute less than 1% of its total mass?", "Is there a structure present with mineral content less than 1% by weight, possibly including sodium, potassium, or calcium ions?", "Does the image include an object that would typically be at a temperature of about 37\u00b0C in the human body?", "Can you see a structure whose lifespan could range from hours to years depending on its type?"], "relational": ["Does the image contain any structure whose anatomical context is ambiguous or cannot be determined?", "Is there an object present for which substructures cannot be identified due to lack of anatomical specificity?", "Can you see any tissue or region that remains undefined without additional context?", "Does the image show any anatomical region whose adjacent areas cannot be established?", "Is there a structure whose interactions with organ systems are indeterminate due to lack of anatomical clarity?", "Can you identify any object for which the relationship to secondary structures cannot be described?", "Does the image include any region where connected vessels or ducts are not identifiable due to insufficient context?", "Is there a structure present for which the cell types cannot be specified without a defined anatomical reference?", "Can you see any organ whose structural relationships are unclear in the absence of precise definition?", "Does the image show any area where anatomical boundaries cannot be defined without additional anatomical information?"], "contexual_behavior": ["Is there evidence in the image of a tissue whose main function appears impaired, possibly due to pathological changes?", "Can you identify a cell type that shows increased activity, which might indicate an adaptive response to stress?", "Does the image suggest an organ whose main role may have shifted, potentially in response to hormonal changes?", "Is there a structure where the main biological process seems slowed, possibly reflecting aging or cellular senescence?", "Can you observe signs of impaired function in a structure that might have suffered injury or inflammation?", "Does the image show a system with accelerated activity, which could indicate activation during acute illness?", "Is there visual evidence of a physiological role changing in response to environmental stress or adaptation?", "Can you identify a structure whose main function appears decreased, possibly due to chronic pathological conditions?", "Does the image suggest altered behavior of a biological structure, potentially as a response to metabolic disturbances?", "Is there a feature indicating enhanced activity or regeneration during recovery from illness?"], "functions": ["Does the image show cells or tissues that are responsible for maintaining normal physiological activity within an organ?", "Can you identify structures that support organ-specific roles through specialized cellular functions?", "Is there evidence of cells performing tasks such as secretion, absorption, or contraction depending on their type?", "Does the image reveal features indicative of tissue maintenance, such as ongoing cell turnover or structural support?", "Can you see signs of repair mechanisms, such as activation of pathways or secretion of signaling molecules in response to injury or stress?", "Is there visual evidence of cell proliferation or differentiation that would suggest regeneration or replacement of damaged tissue?", "Does the image show cells or tissues involved in producing or responding to cytokines, hormones, or growth factors?", "Can you identify features that indicate the performance of core activities essential for organ function and systemic health?", "Is there evidence of feedback mechanisms or receptor-mediated signaling regulating cellular activity in the tissue?", "Does the image show cells presenting antigens or interacting with immune cells, suggesting involvement in immune responses?", "Can you see indications of cells sensing environmental changes or communicating with neighboring cells to maintain homeostasis?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": [], "contexual_behavior": [], "functions": ["Does the image suggest the presence of paired structures that could enable depth perception through binocular vision?", "Does the image show glands or ducts that could be involved in tear production and ocular lubrication?", "Does the image show a structure responsible for detecting light and forming images?"]}}, "metastatic carcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show abnormal tissue invading connective, muscle, epithelial, or nervous tissue?", "Can you identify lesions affecting organs such as the liver, lungs, bones, or brain?", "Is there evidence of abnormal cells utilizing lymphatic vessels or lymph nodes to reach distant sites?", "Does the image suggest a possible origin from tissues like breast, lung, colon, prostate, or skin?", "Can you see signs of disease spreading through the circulatory or lymphatic systems?", "Is there a structure that appears to facilitate the movement of abnormal cells, such as blood vessels, lymphatic vessels, or basement membrane disruption?", "Are there visible abnormalities in regions commonly targeted by secondary tumors, such as the liver, lungs, bones, brain, or lymph nodes?", "Does the image show abnormal cells interacting with or invading blood vessels or capillaries?", "Is there evidence of cells crossing anatomical barriers like the basement membrane, endothelial barriers, or the blood-brain barrier?", "Can you identify both a primary lesion and a separate secondary lesion, suggesting the spread of malignant cells from one site to another?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal cell clusters invading surrounding tissues?", "Can you identify areas where healthy tissue appears to be replaced or disrupted, potentially impairing organ function?", "Is there visual evidence of tissue structures being breached, such as the basement membrane or extracellular matrix?", "Does the image reveal signs of new blood vessel formation that could be stimulated by pro-angiogenic factors?", "Can you see regions where the local tissue environment appears altered, such as increased stromal cell presence or changes in matrix composition?", "Is there evidence of immune cell infiltration or inflammation, possibly due to cytokine release?", "Does the image display features suggestive of fibroblast activation or increased matrix metalloproteinase activity?", "Are there signs of abnormal cellular proliferation or expansion beyond normal tissue boundaries?", "Can you observe areas that might indicate hypoxia or nutrient competition, such as poorly vascularized or necrotic regions?", "Is there visual indication of organ dysfunction or structural compromise, such as distortion or loss of normal architecture?", "Does the image suggest the presence of cells that may be resisting apoptosis or exhibiting survival advantages?", "Can you identify features that could be associated with altered growth factor signaling or disrupted intercellular communication?", "Is there evidence of metastatic spread, such as abnormal cell clusters present in distant organs or tissues?", "Does the image show signs of cachexia or systemic metabolic effects, such as tissue wasting or loss of normal tissue mass?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see any abnormality supplied by pulmonary or bronchial arteries?", "Are there lesions defined by lobar fissures, pleural surfaces, or bronchovascular bundles?", "Is there a suspicious area located in the right lung, particularly in the lower lobe?"], "contexual_behavior": ["Is there a mass that fails to establish in the presence of activated innate immunity, suggesting effective early immune-mediated clearance?", "Does the image suggest a tumor that fails to evade immune detection in a host with intact adaptive immunity?", "Does the image suggest enhanced immune evasion by a tumor after repeated transplantation, possibly indicating selection of immune-resistant variants?"], "functions": []}}, "metastatic lesion": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears to be increasing in size, suggesting disease progression or inadequate response to therapy?", "Is there an area that has decreased in size, indicating a possible response to treatment or tumor cell death?", "Can you identify a region that has changed shape, possibly due to invasion into surrounding tissue or effects of therapy?", "Does the image reveal a structure with increased vascularity, which might indicate angiogenesis driven by tumor growth?", "Is there a region with altered density, such as areas that appear necrotic, hemorrhagic, fibrotic, or calcified?", "Can you see evidence of necrosis within a lesion, possibly due to insufficient blood supply or cytotoxic therapy?", "Is there a focus of calcification that could be the result of dystrophic mineralization following necrosis?", "Does the image display a lesion with color changes, such as areas of hemorrhage, necrosis, or pigmentation?", "Is there a region with a different texture, perhaps due to fibrosis, necrosis, or cystic degeneration?", "Can you identify a structure that might have increased metabolic activity, suggesting rapid tumor cell proliferation?", "Is there a lesion with a cystic appearance, possibly resulting from central necrosis or liquefaction?", "Does the image show evidence of hemorrhage within a lesion, such as areas of acute bleeding or vessel rupture?", "Is there a region that appears more cellular, which could indicate active tumor growth or a high-grade malignancy?", "Can you see a structure that has lost its normal integrity, possibly due to extensive necrosis or rapid growth?", "Is there a lesion surrounded by a fibrous capsule, suggesting a chronic process or host tissue reaction?", "Does the image show edema around a lesion, which might result from vascular disruption or inflammation?", "Is there a region with heterogeneous composition, displaying mixed areas of necrosis, hemorrhage, fibrosis, or viable tumor tissue?", "Can you identify a lesion that would likely show increased uptake on a PET scan due to elevated glucose metabolism?", "Is there evidence of a structure becoming more infiltrative, with tumor cells invading adjacent tissues?", "Does the border of a lesion appear less defined or altered, possibly due to invasive growth or therapeutic response?"], "properties": ["Is there a structure in the image that appears irregular or nodular in shape?", "Can you identify an area that ranges in size from a few millimeters to several centimeters?", "Does the image show a mass with a gray-white or tan coloration?", "Is there a region that appears denser than the surrounding normal tissue, possibly with areas of variable density?", "Can you see a lesion that might contain both malignant and inflammatory cells?", "Is there evidence of increased vascularity or new blood vessel formation within any abnormal structure?", "Does any area display features suggestive of high cellular proliferation, such as a high mitotic index?", "Is there a region where the cells seem to have a high nuclear-to-cytoplasmic ratio?", "Can you identify a mass that appears firm or hard, with possible softer areas indicating necrosis?", "Is there a lesion that seems poorly or moderately differentiated compared to surrounding tissue?", "Does any structure show signs of rapid or accelerated growth relative to other lesions?", "Can you see evidence of necrosis, such as areas of tissue breakdown within a mass?", "Is there a region that might express proteins like cytokeratins, vimentin, or HER2, depending on the tumor type?", "Does any lesion appear to have variable or increased lipid content, possibly indicating adipogenic differentiation?", "Is there an area where the water content appears normal or slightly increased, perhaps due to edema?", "Can you identify a mass with occasional calcification, especially if the tumor type is known to be mucinous?", "Is there a region that might harbor genetic alterations such as KRAS, TP53, or EGFR mutations?", "Does any abnormal structure exhibit an acidic microenvironment, possibly reflecting increased glycolysis and hypoxia?"], "relational": ["Does the image show an abnormal area within epithelial, connective, nervous, or muscle tissue?", "Is there a suspicious region affecting organs such as the liver, lungs, brain, or bones?", "Can you identify a structure that might represent the spread of malignant cells from a primary tumor to a distant site?", "Is there evidence of involvement in the skeletal, nervous, respiratory, or digestive systems?", "Does the image display an abnormality adjacent to parenchyma, blood vessels, lymphatic vessels, or connective tissue?", "Can you see a region that could contain malignant tumor cells along with stromal or immune cells?", "Is there a visible pattern suggesting spread through blood vessels or lymphatic channels?", "Does the image show an area located in common secondary sites such as the liver, lungs, brain, bones, or lymph nodes?", "Can you identify any lymphatic structures, such as lymph nodes or lymphatic vessels, associated with an abnormal region?", "Is there a suspicious area near veins, capillaries, arteries, or venules that could indicate dissemination?"], "contexual_behavior": ["Does the image show a structure that could be invading surrounding tissues, possibly due to increased protease activity or features of epithelial-mesenchymal transition?", "Is there evidence of a mass with limited new blood vessel formation, which might suggest inhibition of angiogenic signaling?", "Can you identify a lesion that may be evading immune detection, potentially through expression of immune checkpoint molecules or reduced antigen presentation?", "Does the image contain a region where cell proliferation appears reduced, possibly as a response to chemotherapy?", "Is there a structure that might be resisting programmed cell death, perhaps through upregulation of anti-apoptotic proteins?", "Can you see a lesion that could be adapting to a low-oxygen environment by increasing glycolytic activity?", "Is there evidence of extracellular matrix degradation near a mass, which could indicate increased secretion of matrix metalloproteinases?", "Does the image suggest a lesion that is failing to establish itself in a new organ, possibly due to incompatibility with the local microenvironment?", "Can you observe impaired migration of abnormal cells, potentially due to altered expression of adhesion molecules?", "Is there a mass whose growth rate might be influenced by hormonal signals, suggesting the presence of hormone-sensitive receptors?", "Does the image show a lesion with reduced spread, possibly as a result of targeted therapy inhibiting oncogenic pathways?", "Is there evidence that a mass is altering its behavior in response to changes in the surrounding tissue environment?", "Can you identify a lesion that may be more resistant to radiotherapy, potentially due to enhanced DNA repair or antioxidant activity?", "Is there a structure with reduced recruitment of stromal support cells, possibly due to decreased chemokine signaling?", "Does the image suggest enhanced dissemination of abnormal cells in the context of systemic inflammation and increased cytokine activity?", "Can you see a lesion that appears functionally impaired, possibly due to nutrient deprivation in its microenvironment?", "Is there evidence of increased immune evasion following immunosuppressive treatment, such as enhanced activation of immune inhibitory pathways?", "Does the image show a mass with reduced spread and limited neovascularization, potentially as a result of anti-angiogenic therapy?", "Can you observe features suggesting that a lesion is responding to oxidative stress by modulating its signaling pathways or increasing antioxidant defenses?", "Is there evidence that abnormal cells are surviving in circulation, possibly through resistance to anoikis or interaction with platelets or immune cells?"], "functions": ["Does the image show evidence of a secondary tumor site distant from a possible primary tumor?", "Can you identify a structure that suggests tumor dissemination or secondary growth in a new tissue?", "Is there a region that appears to disrupt normal tissue architecture, indicating possible tissue invasion or functional impairment?", "Does the image reveal any abnormal mass that could be interfering with organ function at its location?", "Can you see features that might indicate the spread of malignant cells through the bloodstream or lymphatic system?", "Is there evidence of local tissue inflammation or remodeling of the extracellular matrix near an abnormal structure?", "Does the image contain a mass that could be modulating the local immune response or evading immune surveillance?", "Can you identify signs of new blood vessel formation, such as angiogenesis, associated with an abnormal growth?", "Is there a region that appears hypoxic or shows signs of rapid proliferation outcompeting normal cells for resources?", "Does the image suggest the presence of heterogeneous cell populations within a tumor, potentially indicating therapy resistance?", "Are there visual cues of aberrant cellular signaling, such as abnormal tissue growth or altered paracrine effects?", "Can you see evidence of systemic effects, such as tissue wasting or features consistent with cachexia, that might be linked to a tumor?", "Is there a structure that could be releasing cytokines or contributing to paraneoplastic syndromes?", "Does the image show any abnormality that might be associated with the metastatic cascade, such as signs of cell migration or colonization in a distant tissue?"]}, "no_questions": {"contexual_properties": ["Does the image display any features that might correspond to lesions affecting neural function?", "Is there evidence of localized disruptions that could be associated with disease processes in the brain?", "Does the image show any abnormal areas that could indicate tissue damage within the central nervous system?"], "properties": ["Can you identify regions with altered coloration or texture compared to the surrounding tissue?", "Does the image contain any localized changes that might correspond to lesions in brain tissue?", "Are there visible features that suggest damage or disease within the neural tissue?"], "relational": ["Does the image show a structure that is part of the central nervous system?", "Does the image contain small blood vessels like capillaries, arterioles, or venules near the abnormal area?", "Can you see distinct areas corresponding to cortex, subcortical structures, or a region of abnormality?"], "contexual_behavior": ["Is there evidence of disrupted tissue or blood accumulation that could impair cerebrospinal fluid dynamics and affect intracranial pressure after hemorrhage?", "Is there any indication of neuronal dysfunction that could affect neurotransmitter release, as seen in neurodegenerative diseases?", "Does the image show evidence of disrupted neural connectivity that could impair signaling during inflammation?"], "functions": ["Can you identify a region that might influence emotional regulation, such as causing mood swings?", "Does the image contain an abnormality that might result in motor dysfunction such as weakness or ataxia?", "Can you see a region that might influence autonomic functions, such as blood pressure or heart rate regulation?"]}}, "inner table": {"yes_questions": {"contexual_properties": ["Is there a bony structure in the image that appears thickened, which could be seen in conditions like hyperostosis frontalis interna or chronic meningioma?", "Can you identify an area of bone that appears thinned, as might occur with osteoporosis or chronic increased intracranial pressure?", "Does the image show a region of bone with increased porosity, which could suggest a metabolic bone disease such as osteomalacia or Paget\u2019s disease?", "Is there evidence of irregularities in a bony layer that might result from trauma, infection, or neoplastic infiltration?", "Can you see a sclerotic appearance in a bone structure, possibly due to chronic inflammation or repeated injury?", "Is there an area of bone erosion visible, which could be associated with metastatic disease, chronic infection, or tumor invasion?", "Does the image reveal changes in bone density that might be related to metabolic disorders, neoplastic processes, or trauma?", "Is there a region of bone that appears hyperostotic, as might be seen in meningioma or hyperostosis frontalis interna?", "Can you detect lytic lesions in a bony layer, which could indicate metastatic cancer, multiple myeloma, or infection?", "Is there abnormal calcification present in a bone structure, possibly due to chronic inflammation, metabolic disorder, or trauma?", "Does the image show a roughened surface on a bony layer, which could result from chronic infection, trauma, or neoplastic infiltration?", "Can you identify loss of structural integrity in a bone, as might be seen in severe osteoporosis, extensive lytic lesions, or advanced infection?", "Is there a thickened appearance of a bony layer on imaging, which could be associated with hyperostosis, meningioma, or increased intracranial pressure?", "Does the image show deformation of a bone structure, possibly following trauma, congenital skull abnormality, or neoplastic growth?", "Is there increased radiopacity in a bony region, which could be due to sclerotic bone conditions, chronic inflammation, or bone healing?"], "properties": ["Is there a cranial structure in the image with a thickness typically between 0.5 and 1.5 millimeters?", "Can you identify a region of the cranial vault that appears dense, consistent with a compact bone density of around 1.8 to 2.0 g/cm\u00b3?", "Does the image show a layer composed primarily of compact bone with a matrix likely containing hydroxyapatite and collagen fibers?", "Is there a pale ivory or white, smooth and hard surface visible along the inner aspect of the cranial vault?", "Can you see a structure that appears flat or gently curved, following the contour of the cranial vault?", "Is there evidence of a bone layer with low porosity, typically less than 10%?", "Does the image reveal a region with a width close to 1 millimeter, possibly varying by cranial location?", "Can you identify a bone layer that is likely to contain osteocytes, osteoblasts, and osteoclasts within its matrix?", "Is there a compact bone region that would be expected to have a water content of about 10\u201320% by weight?", "Does the image show a structure whose mineral content is predominantly hydroxyapatite, with significant calcium and phosphate?", "Is there a bone layer that could contain type I collagen making up about 20\u201330% of its organic matrix?", "Can you identify a region where the calcium concentration is likely around 25\u201330% by weight and phosphorus is about 12\u201315%?", "Does the image reveal tightly packed osteons and lamellae characteristic of cortical bone organization?"], "relational": ["Does the image show a component of the cranial bones that forms part of the skull?", "Is there a structure present in the calvarial region of the skull?", "Can you identify a layer that lies adjacent to both the diplo\u00eb and the dura mater?", "Does the image display the three-layered organization of cranial bone, including a layer between the diplo\u00eb and the cranial cavity?", "Is there evidence of a structure that forms the internal surface of the cranial bones?", "Can you see a layer that is in contact with the dura mater or other meningeal tissues?", "Does the image include a feature that separates the diplo\u00eb from the cranial cavity?", "Is there a structure contributing to the architecture of the cranial vault?", "Can you identify a layer present within the frontal, parietal, temporal, or occipital bones of the cranial vault?"], "contexual_behavior": ["Is there evidence of a cranial structure that appears more susceptible to fracture under high-impact trauma or in the presence of bone fragility?", "Can you identify a region of bone that may show impaired protective function in the context of osteomyelitis or other bone diseases?", "Does the image reveal any area of the skull with signs of decreased bone mineral density or increased porosity, suggestive of osteoporosis?", "Is there a bony layer whose barrier function might be compromised due to infection or inflammation?", "Can you observe any indication of active bone remodeling or changes consistent with skull growth or healing after cranial injury?", "Is there a part of the cranial bone that could show altered resistance to pressure, possibly due to metabolic bone disorders such as hyperparathyroidism or rickets?", "Does the image show a region where the bone fails to protect the brain, as might occur in severe head injury with fracture or displacement?", "Can you see any evidence of increased bone resorption or osteoclastic activity in response to chronic inflammation?", "Is there a layer of bone that appears thinned or less supportive of the outer table, possibly due to aging and loss of density?", "Does the image suggest any functional alteration of a cranial bone layer, such as might occur during cranial surgery or trauma repair?"], "functions": ["Does the image show a dense, compact layer within a cranial bone that provides structural support?", "Is there a hard barrier visible that could help shield the brain from external forces or injuries?", "Can you identify a region of cranial bone that appears to add rigidity and resistance to deformation?", "Does the image contain a structure that reinforces the inner aspect of the skull to help prevent fractures?", "Is there a smooth surface present that could serve as an attachment site for the meninges lining the cranial cavity?", "Can you see a protective layer situated between neural tissue and the outer skull that might shield against trauma?", "Does the image include a component of cranial bone that appears to maintain bone density and contribute to overall skull durability?"]}, "no_questions": {"contexual_properties": ["Is there visual evidence of a change in heart rate, such as tachycardia, that could be a response to hypotension?", "Does the image display signs consistent with rapid mediator release, such as mast cell activation?", "Can you see visible hives or urticaria that could have formed within minutes following exposure to an allergen?"], "properties": ["Is there evidence of swelling or welts measuring between 1 and 10 centimeters in diameter?", "Can you see indications of decreased blood oxygen saturation, such as cyanosis?", "Does the image suggest a rapid onset of symptoms occurring within 30 minutes of exposure?"], "relational": ["Is there evidence of a reaction occurring in the skin, nasal mucosa, bronchi, or gastrointestinal tract?", "Does the image show engagement or disruption of anatomical barriers such as the epithelial, endothelial, or mucosal barriers?", "Does the image show evidence of a process involving the immune, integumentary, or respiratory systems?"], "contexual_behavior": ["Is there any indication of impaired immunity or mast cell dysfunction that could be seen in immunodeficient patients?", "Does the image indicate altered immune cell activation or mediator release that could occur during acute infection?", "Does the image show evidence of a process that becomes exaggerated during allergic responses involving IgE and mast cell degranulation?"], "functions": ["Is there visual indication of degranulation or mediator release from immune cells?", "Can you identify signs of an IgE-mediated allergic reaction, such as mast cell activation?", "Can you see evidence of complement activation in the tissue?"]}}, "prostate": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears enlarged, as might be seen in benign growths or malignant tumors?", "Can you identify an organ that appears shrunken, possibly due to hormonal therapy or age-related changes?", "Is there a structure with altered texture, which could indicate malignancy, chronic inflammation, or fibrotic changes?", "Does the image reveal an area that appears firmer than surrounding tissue, suggestive of cancer, fibrosis, or chronic inflammation?", "Can you see a region that looks softer, which might be associated with acute inflammation or abscess formation?", "Is there evidence of nodular formations that could be related to benign hyperplasia or neoplastic processes?", "Does the structure display an irregular or asymmetric shape, possibly due to unilateral nodules, tumors, or cysts?", "Are there visible calcifications within a glandular structure, which might result from chronic inflammation, aging, or prior infection?", "Can you identify signs of inflammation, such as swelling or redness, that could indicate an infectious or inflammatory process?", "Is there a change in color within the tissue, potentially due to hemorrhage, necrosis, or inflammation?", "Does the organ appear heavier or bulkier, as might occur in benign hyperplasia or neoplastic growth?", "Is there evidence of decreased size or weight, which could be due to atrophy, hormonal therapy, or aging?", "Can you see cystic areas that may have formed from ductal obstruction or congenital anomalies?", "Is there abnormal tissue composition, such as areas of irregular density or structure, possibly indicating cancer, inflammation, or fibrosis?", "Does the structure show increased vascularity, which might be associated with malignancy or chronic inflammation?", "Are there regions of necrosis visible, as could occur in advanced cancer or severe infection?", "Can you identify areas with increased cellularity, suggestive of hyperplasia or malignancy?", "Does the tissue appear less elastic, which may be due to fibrosis, chronic inflammation, or aging?"], "properties": ["Is there a structure in the image that measures approximately 3 cm in height, 4 cm in width, and 2 cm in depth?", "Can you identify an object with an average weight of about 20 to 30 grams?", "Does the image show a chestnut-shaped or rounded-conical structure?", "Is there a grayish-white anatomical entity present?", "Can you see a structure with a volume around 20 to 30 milliliters?", "Is there an object that appears firm and rubbery in texture?", "Does the image contain a structure composed of secretory epithelial cells, basal cells, neuroendocrine cells, and stromal cells?", "Can you identify an anatomical entity with approximately 80% water content by weight?", "Is there a structure with a density close to 1.05 grams per cubic centimeter?", "Does the image show an object that would have a slightly acidic pH, typically between 6.4 and 6.7?", "Is there a structure known for high zinc concentration, ranging from 1,000 to 3,000 micrograms per gram of tissue?", "Can you see an anatomical entity with elevated citrate levels, typically 40 to 150 millimoles per kilogram?", "Is there a structure with a calcium concentration of about 1 to 2 milligrams per gram of tissue?", "Does the image contain an object whose protein content is approximately 10 to 15% of its wet weight?", "Can you identify a structure that produces enzymes such as prostate-specific antigen, acid phosphatase, or kallikrein-related peptidases?", "Is there an anatomical entity with a PSA concentration around 0.5 to 2 micrograms per gram?", "Does the image show a structure divided into five lobes: anterior, posterior, median, and two lateral lobes?", "Can you see an object with a lipid content of about 2 to 5% of its wet weight?", "Is there a structure with a temperature close to 37\u00b0C?", "Does the image contain an anatomical entity where connective tissue comprises about 30% of its total volume?"], "relational": ["Does the image show a structure that is part of the male reproductive system?", "Can you identify an organ located near the bladder and rectum?", "Is there a structure adjacent to the seminal vesicles?", "Does the image contain a region connected to the ejaculatory ducts?", "Can you see an area where the urethra passes through an organ, forming a distinct passage?", "Is there evidence of anatomical support from pelvic floor muscles or puboprostatic ligaments for a structure in the image?", "Does the image display zones such as peripheral, central, or transitional regions within a single organ?", "Can you identify a structure that receives blood supply from the inferior vesical artery or middle rectal artery?", "Is there an organ in the image associated with the internal pudendal artery?", "Does the image show a region containing glandular epithelium, fibromuscular stroma, or connective tissue?", "Can you see a structure that interacts with both the seminal vesicles and the vas deferens during ejaculation?", "Is there an organ in the image that is anatomically related to the bulbourethral glands?", "Does the image contain a structure that forms part of the urethral passage?"], "contexual_behavior": ["Is there a structure in the image that increases its secretory activity during sexual stimulation?", "Can you identify an object whose contribution to semen volume would decrease after surgical removal or in cases of androgen deficiency?", "Does the image show a gland that may fail to support sperm motility effectively in the presence of chronic inflammation?", "Is there a structure that would increase inflammatory mediator production during prostatitis?", "Can you see an object that might decrease its function due to aging and reduced androgen levels?", "Is there a gland in the image that could show enlargement and altered secretion in benign prostatic hyperplasia?", "Does the image contain a structure that would increase its metabolic activity during malignant transformation?", "Can you identify an object that reduces zinc secretion under chronic inflammation or malignancy?", "Is there a structure that may fail to regulate the pH of seminal fluid in cases of infection or gland dysfunction?", "Can you see an object whose function is altered in response to fluctuations in testosterone or dihydrotestosterone?", "Is there a gland that would decrease its secretory output after hormone therapy or castration?", "Does the image show a structure that may exhibit reduced function following surgical intervention such as transurethral resection?", "Is there an object that increases immune cell infiltration and changes its secretion composition during acute infection?", "Can you identify a structure that fails to maintain normal seminal viscosity in disease states like chronic inflammation or malignancy?"], "functions": ["Does the image show a structure that produces a fluid essential for supporting sperm motility?", "Is there an object present that contributes a slightly alkaline secretion to semen?", "Can you identify a structure that plays a role in male fertility by providing nutrients and enzymes to enhance sperm viability?", "Does the image contain something that surrounds the urethra and helps regulate the flow of urine?", "Is there a visible structure that produces a fluid containing enzymes, zinc, and citric acid?", "Can you see an object that releases substances to activate and protect sperm cells during ejaculation?", "Is there a structure present that secretes antimicrobial agents and buffering substances to protect sperm from acidic environments?", "Does the image include a gland that responds to androgens such as testosterone and dihydrotestosterone?", "Can you identify a component of the male reproductive system that facilitates ejaculation and supports sperm health?", "Is there a structure that influences the pH of seminal fluid by secreting alkaline substances to optimize sperm survival?"]}, "no_questions": {"contexual_properties": ["Is there evidence of epithelial changes within a ductal lesion that suggest transformation toward apocrine cell characteristics?", "Can you identify a ductal abnormality characterized by the presence of multiple papillary growths and areas resembling apocrine metaplasia?", "Does the image show a lesion within a ductal structure that contains multiple papillary projections?"], "properties": ["Does the image contain a lesion with numerous delicate papillary fronds within dilated ducts?", "Is there a structure composed of papillary epithelial cells and myoepithelial cells?", "Does the image show a lesion with multiple papillary or frond-like structures?"], "relational": ["Does the image reveal structures supported by a myoepithelial layer, basement membrane, or surrounding stroma?", "Does the image display tissue types such as epithelial, stromal, or apocrine metaplastic tissue?", "Can you identify any abnormalities affecting mammary ducts or breast lobules?"], "contexual_behavior": ["Can you identify areas where the lining of a duct appears to have undergone a change resembling apocrine cells?", "Can you see any regions where the ductal epithelium appears altered or metaplastic?", "Does the image show any abnormal growths within a ductal structure?"], "functions": ["Are there multiple papillary projections visible within a single ductal space?", "Is there evidence of tissue remodeling or changes in the surrounding stroma adjacent to ductal lesions?", "Can you observe replacement of typical ductal epithelium by cells with apocrine characteristics?"]}}, "ear lobe horizontal crease": {"yes_questions": {"contexual_properties": ["Does the image show a crease on the ear lobe that appears more prominent in older adults or individuals with cardiovascular risk factors?", "Can you observe a horizontal line on the ear lobe that seems deeper in areas where the skin looks less elastic or thinner?", "Is there a visible ear lobe feature that appears wider in individuals who may have chronic systemic conditions or advanced age?", "Do you notice any color changes along a horizontal crease on the ear lobe that could indicate inflammation, bruising, or vascular changes?", "Is there a reduction in the visibility of a horizontal ear lobe crease in areas where the skin appears tighter or after cosmetic intervention?", "Can you identify a horizontal crease present on both ear lobes, especially in an older individual or someone with bilateral risk factors?", "Are there multiple horizontal lines or additional creases on the ear lobe that might suggest repetitive mechanical stress or further aging?", "Does the horizontal crease on the ear lobe appear alongside thickened skin, possibly indicating chronic dermatitis or lymphedema?", "Is there swelling around a horizontal ear lobe crease that could be due to local infection, trauma, or an allergic reaction?", "Do you see any changes in the texture of a horizontal crease on the ear lobe, such as roughness or irregularity, that might suggest scarring, fibrosis, or chronic skin disease?", "Is the horizontal crease on the ear lobe more noticeable in areas where the skin shows cumulative aging changes or loss of elasticity?", "Can you spot a horizontal crease on the ear lobe of a younger individual, which might be associated with a genetic syndrome or premature aging disorder?", "Does the horizontal crease on the ear lobe coincide with changes in ear lobe size, such as atrophy or hypertrophy of the tissue?", "Is there evidence of decreased elasticity in the ear lobe, such as sagging or folding, that could be related to collagen or elastin fiber degradation near a horizontal crease?", "Do you observe discoloration of the skin surrounding a horizontal ear lobe crease, possibly due to vascular compromise, bruising, or a dermatological condition?"], "properties": ["Does the image show a linear, horizontal indentation on the anterior surface of the ear lobe, extending from the tragus toward the lower margin?", "Can you identify a shallow crease, less than 1 millimeter deep, on the ear lobe?", "Is there a feature on the ear lobe that measures approximately 1 to 2 centimeters in length?", "Does the ear lobe display a crease with a width of about 1 to 2 millimeters?", "Can you observe a smooth, indented line on the ear lobe that matches the surrounding skin color or appears slightly darker?", "Is there a horizontal crease present on both ear lobes rather than just one?", "Does the image show a feature on the ear lobe that is more commonly seen in adults over 50 years of age?", "Can you see a crease on the ear lobe that typically appears after the age of 40?", "Is there a visible indentation on the ear lobe that is more likely to be found bilaterally than unilaterally?"], "relational": ["Does the image show a surface marking located on the external ear?", "Can you identify a feature situated within the inferior part of the ear lobe?", "Is there a visible crease in the lateral region of the head, specifically in the auricular area?", "Does the image contain a marking composed of skin, subcutaneous tissue, and connective tissue on the ear lobe?", "Can you see a structure adjacent to the lower margin of the auricle or near the preauricular region?", "Is there a surface feature found close to anatomical landmarks such as the tragus, antitragus, or lobule margin?", "Does the image display a marking that is part of the integumentary system and located on the external ear?", "Can you observe a crease associated with the skin and underlying connective tissue of the ear lobe?"], "contexual_behavior": ["Does the image show a feature that becomes more pronounced in individuals with coronary artery disease?", "Is there a visible sign that could indicate impaired microcirculation due to reduced capillary blood flow in the tissue?", "Can you identify a feature that often correlates with reduced tissue elasticity as a result of aging?", "Does the image contain a marker that may reflect altered collagen metabolism in someone with diabetes mellitus?", "Is there a visible characteristic that becomes more apparent during the progression of systemic atherosclerosis?", "Can you see a feature associated with impaired wound healing in conditions affecting vascular or connective tissue health?", "Is there a visible sign that may deepen in response to chronic cardiovascular stress such as persistent hypertension?", "Does the image show a feature that can signal decreased peripheral blood flow, particularly in peripheral arterial disease?", "Can you identify a characteristic that may become less apparent after improvement in cardiovascular health and restoration of vascular function?", "Is there a visible sign that can indicate altered connective tissue function in the context of metabolic syndrome?"], "functions": ["Does the image show a physical feature that is sometimes considered during health assessments?", "Can you identify a visible sign that may be used as a clinical marker for certain conditions?", "Is there a crease present that could be associated with increased cardiovascular risk?", "Does the image contain a physical sign that might be noted during a cardiovascular assessment?", "Can you see a feature that, while having no known physiological function, is sometimes evaluated in medical examinations?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a visible area covered by tissues such as the periosteum, connective tissue, or scalp?", "Can you identify bones such as the frontal, parietal, occipital, or temporal bones in the image?", "Is there evidence of sutures like the coronal, sagittal, or lambdoid sutures connecting bones in the image?"], "contexual_behavior": [], "functions": ["Does the image show a structure that forms the upper part of the cranial cavity?", "Does the image contain a structure that helps maintain the integrity and stability of the skull?", "Is there a structure visible that encases and shields major cranial blood vessels?"]}}, "skull cap": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that forms part of the cranium?", "Can you identify bones such as the frontal, parietal, or occipital within the image?", "Is there a region adjacent to the scalp or temporal area visible?", "Does the image display connections between bones that could represent coronal, sagittal, or lambdoid sutures?", "Can you see a surface covered by tissues like periosteum or skin?", "Is there a structure that encloses a cavity for the brain?", "Does the image show a boundary forming the uppermost part of the cranial cavity?", "Are there features suggesting the presence of meninges or blood vessels beneath a bony surface?", "Can you identify membranes such as dura mater, arachnoid mater, or pia mater lining the inner surface of a structure?", "Is there evidence of protection for superior brain structures or the cerebrum in the image?"], "contexual_behavior": ["Is there evidence of a cranial structure with fractures or defects that could reduce brain protection during trauma?", "Does the image show signs of bone density loss or increased brittleness that might indicate decreased impact absorption with age?", "Can you identify areas of bone thinning or reduced mineral content that could suggest osteoporosis affecting cranial protection?", "Are there visible features consistent with congenital defects, such as abnormal bone formation or early suture closure, that might compromise cranial shielding?", "Does the cranial region appear to facilitate increased heat dissipation, possibly in response to fever?", "Is there any indication of disrupted bone integrity due to infection or inflammation, such as changes seen in osteomyelitis?", "Can you observe impaired healing or poor vascular supply in the cranial bones following a fracture?", "Are there structural changes in the cranial region that could be attributed to metabolic bone diseases like rickets or Paget\u2019s disease?", "Does the image reveal localized thinning or remodeling of cranial bones that might result from chronic pressure?", "Are there signs of impaired bone mineralization, such as decreased resistance to penetration, that could be linked to vitamin D deficiency?", "Is there evidence of a depressed fracture or loss of bone continuity that could affect the maintenance of intracranial pressure after injury?", "Can you see alterations in cranial bone structure that might result from surgical removal or repositioning of bone flaps?", "Does the cranial region display features of age-related bone thinning or decreased elasticity, particularly in elderly individuals?", "Are there visual cues of compromised bone matrix or reduced strength in the cranial bones that could be associated with malnutrition?", "Does the image suggest that the cranial structure is serving as a primary barrier against external forces, especially in the context of high-risk activities?"], "functions": ["Does the image show a structure that provides a rigid barrier shielding the brain from external trauma?", "Is there a bony enclosure that helps maintain the shape and stability of the upper portion of the head?", "Can you identify a feature that serves as a protective enclosure for sensory organs such as the eyes and ears?", "Does the image contain a curved bone that could absorb and distribute mechanical forces from impacts?", "Is there a surface present that offers attachment sites for scalp muscles involved in movement and expression?", "Can you see a structure that encloses and safeguards the brain and meninges from external harm?", "Is there evidence of a rigid enclosure that helps maintain intracranial pressure by housing the brain and cerebrospinal fluid?", "Does the image include a bony structure that protects blood vessels within the cranial cavity by encasing them?", "Can you identify a feature that provides structural support to the head and helps prevent brain injury?", "Is there a visible component that contributes to the dissipation of mechanical forces across its curved surface to minimize localized damage?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see a moist environment, possibly due to exudate or tissue fluid?", "Does the image reveal exposed subcutaneous tissue, muscle, or bone?", "Is there a region where the tissue appears to have a reduced density compared to surrounding intact areas?"], "relational": ["Does the image contain a defect involving anatomical layers like the epidermis, dermis, or subcutaneous fat?", "Can you see exposed cell types such as fibroblasts or myocytes due to tissue loss?", "Can you identify a region where internal organs like the intestine or liver might be exposed or affected?"], "contexual_behavior": [], "functions": ["Does the image display an area that might be experiencing impaired regeneration due to its size?", "Is there exposed tissue that could increase the risk of infection?", "Can you see signs of compromised blood flow, such as pallor or tissue ischemia, in any area?"]}}, "prostate primary": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the male reproductive system?", "Can you identify an object located within the pelvic cavity?", "Is there a structure composed of glandular tissue and fibromuscular stroma?", "Does the image contain a region with connective tissue in the pelvic area?", "Can you see an object adjacent to the bladder or rectum?", "Is there a structure positioned near the seminal vesicles?", "Does the image show something connected to the prostatic ducts or ejaculatory ducts?", "Can you identify a region that receives blood supply from the inferior vesical artery or middle rectal artery?", "Is there a structure whose lymphatic drainage could involve the internal iliac or obturator lymph nodes?", "Does the image include an object that surrounds the proximal portion of the urethra?", "Can you see a region forming the prostatic urethra?", "Is there a structure with visible anatomical layers such as a capsule or distinct zones?", "Can you identify peripheral, central, or transitional zones within a structure in the pelvic region?"], "contexual_behavior": ["Is there a structure in the image that increases its fluid secretion during sexual arousal or ejaculation?", "Can you identify an object whose secretory function might be reduced during inflammation, such as in prostatitis?", "Does the image show a structure that may fail to contribute to semen composition in cases of advanced cancer or severe infection?", "Is there an anatomical entity whose function could be impaired by hormonal imbalance, particularly with decreased androgen levels?", "Can you see a structure that typically alters its secretory activity as part of the normal aging process, often resulting in reduced output?", "Is there an object that decreases its contribution to fertility in pathological conditions like chronic inflammation or malignancy?", "Does the image contain a structure that increases production of a specific antigen during malignancy, especially in cancerous states?", "Can you identify an entity that reduces its role in supporting sperm motility after infection due to impaired secretion?", "Is there a structure that may fail to regulate seminal pH under physiological or psychological stress?", "Does the image show an object that alters its function during benign enlargement, often leading to changes in secretion and urinary symptoms?", "Can you see a structure that decreases its secretory output after therapy aimed at reducing androgen levels, as in certain cancer treatments?", "Is there an anatomical entity that increases release of inflammatory mediators during episodes of inflammation?", "Does the image include a structure that shows impaired function following radiation therapy, which can damage glandular tissue?", "Can you identify an object that changes its secretory profile in response to dietary factors such as high-fat diets or phytoestrogen intake?", "Is there a structure that reduces its functional capacity after surgical intervention, such as removal or resection?"], "functions": ["Does the image contain a structure responsible for secreting fluid that contributes significantly to semen?", "Can you identify an organ that adds enzymes and nutrients to semen to support sperm motility and viability?", "Is there a structure present that facilitates sperm transport and supports male fertility through its secretions?", "Does the image show an organ that regulates seminal fluid composition by releasing substances such as zinc and citric acid?", "Can you see a structure that produces antioxidant-rich fluid and antimicrobial proteins to protect sperm?", "Is there an object that secretes enzymes like prostate-specific antigen (PSA) essential for sperm motility and semen liquefaction?", "Does the image include a structure that surrounds the urethra and helps control urine flow by contracting smooth muscle fibers?", "Can you identify an organ that responds to androgens and influences local hormone activity?", "Is there a structure that contributes to semen liquefaction after ejaculation by releasing PSA to break down seminal coagulum?", "Does the image show an organ that enhances antimicrobial defense in the male reproductive tract by secreting antimicrobial peptides and proteins?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see an object surrounded by bones like the frontal, zygomatic, maxillary, or sphenoid bones?", "Does the image show something associated with cranial nerves like the oculomotor, trochlear, or abducens nerves?", "Is there a structure whose position or orientation could be influenced by extraocular muscles?"], "contexual_behavior": [], "functions": ["Can you identify structures capable of smooth pursuit or rapid movement to track moving objects?", "Is there a structure that could provide visual cues important for maintaining balance and spatial orientation?", "Does the image contain a feature that adjusts its opening size in response to changes in light intensity?"]}}}
[ { "answer": "close-up of obvious lesion primary in prostate", "extracted_concepts": [ "obvious lesion", "primary lesion", "prostate" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "obvious lesion primary in prostate", "prostate" ], "question": "does this image show close-up of obvious lesion primary in prostate?" }, { "answer": "no", "extracted_concepts": [ "obvious lesion", "intrauterine contraceptive device", "prostate" ], "question": "does intrauterine contraceptive device show close-up of obvious lesion primary in prostate?" }, { "answer": "metastatic carcinoma", "extracted_concepts": [ "metastatic carcinoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "metastatic carcinoma" ], "question": "is metastatic carcinoma present?" }, { "answer": "no", "extracted_concepts": [], "question": "is stein leventhal present?" }, { "answer": "metastatic carcinoma", "extracted_concepts": [ "metastatic carcinoma" ], "question": "what is present?" } ]	["primary lesion", "metastatic carcinoma", "intrauterine contraceptive device", "prostate", "obvious lesion", "obvious lesion primary in prostate"]	{"primary lesion": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to have increased in size, possibly due to cellular proliferation or fluid accumulation?", "Can you identify an area that has decreased in size, suggesting healing or response to therapy?", "Is there a region showing a change in color that could be attributed to hemorrhage, pigmentation, or inflammation?", "Do you see a raised area that might result from edema, cellular infiltration, or tissue hyperplasia?", "Is there evidence of surface breakdown, such as ulceration, that could be due to necrosis, trauma, or infection?", "Can you find a region that appears indurated, possibly from fibrosis, chronic inflammation, or tumor infiltration?", "Is there a structure with an irregular shape, potentially due to abnormal growth or merging with adjacent areas?", "Do you observe multiple similar structures that could indicate disease progression or dissemination?", "Is there an area with visible fluid accumulation, such as vesiculation, blistering, or exudation?", "Can you see a crusted surface that may have formed from drying of exudate, serum, or blood?", "Is there a region with altered texture, such as increased keratinization, fibrosis, or edema?", "Do you notice any pigmented areas that might result from melanin or hemosiderin deposition?", "Is there a region showing signs of tissue necrosis, possibly due to ischemia, infection, or cytotoxic injury?", "Can you identify an area with increased vascularity, suggesting angiogenesis, inflammation, or tumor growth?", "Is there a scaly surface present, which could be due to excessive keratin production or abnormal epidermal turnover?", "Do you observe any purulent discharge that might indicate bacterial infection and neutrophilic infiltration?", "Is there evidence of hemorrhage, such as a region with blood accumulation from vessel rupture or trauma?", "Can you find an area that appears hardened, possibly due to fibrosis, calcification, or chronic inflammation?", "Is there a region that appears softened, which could result from liquefaction necrosis, edema, or enzymatic degradation?", "Do you see a structure with a change in border definition, possibly due to peripheral growth, inflammation, or regression?"], "properties": ["Is there a skin abnormality in the image that varies in size from a few millimeters to several centimeters?", "Can you identify a structure with a round, oval, linear, or irregular outline?", "Does the image show an area with a color such as red, pink, brown, black, or flesh-colored?", "Is there a lesion present with a diameter between 1 mm and 2 cm?", "Can you observe a skin feature that appears smooth, rough, scaly, or verrucous in texture?", "Is there an area that feels or appears soft, firm, hard, or fluctuant?", "Does the image contain a region that is flat, raised, depressed, or atrophic compared to the surrounding skin?", "Can you see a surface that is smooth, crusted, ulcerated, or keratinized?", "Is there a skin change with a well-defined or ill-defined border?", "Does the image show a localized, generalized, grouped, or linear distribution pattern of skin changes?", "Can you identify an area that appears dry, moist, or exudative?", "Is there a region where the temperature is increased compared to adjacent tissue, possibly indicating inflammation?", "Can you observe a skin feature that is hypopigmented, hyperpigmented, or non-pigmented?", "Does the image show increased vascularity, such as erythema or visible telangiectasia?", "Is there a translucent, opaque, or pearly area visible on the skin?", "Can you see evidence of exudate that is absent, scant, moderate, or copious?", "Is there a region that appears ulcerated or non-ulcerated?", "Does the image contain a skin abnormality that appears fluid-filled, solid, or keratinized?"], "relational": ["Is there an abnormal structure originating from epithelial, connective, muscle, or nervous tissue visible in the image?", "Can you identify a region on the skin, mucous membranes, or internal organs that appears disrupted?", "Does the image show an area where healthy tissue is adjacent to an abnormal structure?", "Is there evidence of a structure affecting the integumentary, respiratory, or gastrointestinal system?", "Can you see a region where epithelial cells, inflammatory cells, or neoplastic cells might be involved in its formation?", "Does the image display disruption of normal tissue architecture or signs of local invasion?", "Is there an abnormality present on the skin, oral mucosa, or genital mucosa?", "Can you observe changes involving the epidermis, dermis, or subcutaneous tissue?", "Does the image reveal alterations to blood vessels, nerve endings, or the extracellular matrix near an abnormal area?", "Is there a structure that could serve as the origin for ulceration, infection, or scarring?"], "contexual_behavior": ["Is there a structure in the image that might show impaired inflammation or lack of immune cell response, as could occur in cases of immunodeficiency?", "Can you identify an area that appears to be healing slowly, which could suggest an immunocompromised state or malnutrition?", "Does the image show a lesion that appears enlarged, possibly indicating secondary infection?", "Is there evidence of impaired tissue regeneration, such as poor wound closure, that might be associated with diabetes mellitus?", "Can you see a lesion that appears to be resolving rapidly, which could be a sign of effective antimicrobial therapy?", "Is there a structure showing signs of ulceration, especially in regions where poor circulation might be present?", "Does any lesion in the image appear persistent or chronic, possibly due to ongoing inflammation?", "Can you identify a lesion that seems to have excessive scar tissue, which could be related to genetic disorders like keloid formation or Ehlers-Danlos syndrome?", "Is there a region where the lesion seems to have lost its barrier function, such as open wounds after severe trauma?", "Does the image show abnormal blood vessel growth within a lesion, which could suggest cancer-related angiogenesis?", "Is there a lesion that appears to have reduced immune cell infiltration, as might be seen in elderly individuals?", "Can you identify an area that might be more sensitive to pain, potentially due to acute infection?", "Is there evidence of secondary lesion formation near an existing lesion, possibly due to ongoing irritation or repeated trauma?", "Does any lesion in the image appear to facilitate the spread of infection, as might occur with inadequate immune containment?"], "functions": ["Does the image show an area that could represent the initial manifestation of tissue abnormality in a disease process?", "Is there a region where normal tissue architecture appears disrupted, suggesting the onset of pathological changes?", "Can you identify a site that might be exposing antigens or damaged cells, potentially triggering an immune response?", "Is there evidence of a focal point that could contribute to further tissue damage, inflammation, or spread of pathology?", "Does the image display features consistent with the activation of inflammation, cellular repair, or immune surveillance?", "Can you see localized changes that might indicate increased vascular permeability, cytokine release, or infiltration of immune cells?", "Is there a structure that could serve as a source for the formation or dissemination of additional lesions?", "Does the image include an area where tissue repair pathways, immune cell recruitment, or regeneration might be occurring?", "Can you identify a region that could provide early evidence of disease and serve as a diagnostic marker?", "Is there a site where signaling molecules may be released, the extracellular matrix is altered, or neighboring cell behavior is affected?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a longitudinal slice that reveals internal organization along a specific anatomical plane?", "Can you identify organs such as the brain, heart, kidney, or muscle within the section?", "Is there evidence that the sample could be used to study the nervous, endocrine, or reproductive system?"], "contexual_behavior": ["Is there impaired detection of enzymatic activity, potentially due to prolonged storage leading to enzyme degradation or inactivation?", "Does the section display loss of morphological detail, tissue shrinkage, or distortion that could result from suboptimal dehydration or embedding?", "Does the image show evidence of reduced preservation of cellular structures that might result from inadequate crosslinking or delayed immersion?"], "functions": ["Can you detect lesions, abnormalities, or histopathological changes in the tissue presented?", "Is there evidence of neural tracts or pathways that could be mapped within the central nervous system?", "Can you identify spatial relationships between different anatomical regions along a side-to-side axis in the image?"]}}, "metastatic carcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show abnormal tissue invading connective, muscle, epithelial, or nervous tissue?", "Can you identify lesions affecting organs such as the liver, lungs, bones, or brain?", "Is there evidence of abnormal cells utilizing lymphatic vessels or lymph nodes to reach distant sites?", "Does the image suggest a possible origin from tissues like breast, lung, colon, prostate, or skin?", "Can you see signs of disease spreading through the circulatory or lymphatic systems?", "Is there a structure that appears to facilitate the movement of abnormal cells, such as blood vessels, lymphatic vessels, or basement membrane disruption?", "Are there visible abnormalities in regions commonly targeted by secondary tumors, such as the liver, lungs, bones, brain, or lymph nodes?", "Does the image show abnormal cells interacting with or invading blood vessels or capillaries?", "Is there evidence of cells crossing anatomical barriers like the basement membrane, endothelial barriers, or the blood-brain barrier?", "Can you identify both a primary lesion and a separate secondary lesion, suggesting the spread of malignant cells from one site to another?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal cell clusters invading surrounding tissues?", "Can you identify areas where healthy tissue appears to be replaced or disrupted, potentially impairing organ function?", "Is there visual evidence of tissue structures being breached, such as the basement membrane or extracellular matrix?", "Does the image reveal signs of new blood vessel formation that could be stimulated by pro-angiogenic factors?", "Can you see regions where the local tissue environment appears altered, such as increased stromal cell presence or changes in matrix composition?", "Is there evidence of immune cell infiltration or inflammation, possibly due to cytokine release?", "Does the image display features suggestive of fibroblast activation or increased matrix metalloproteinase activity?", "Are there signs of abnormal cellular proliferation or expansion beyond normal tissue boundaries?", "Can you observe areas that might indicate hypoxia or nutrient competition, such as poorly vascularized or necrotic regions?", "Is there visual indication of organ dysfunction or structural compromise, such as distortion or loss of normal architecture?", "Does the image suggest the presence of cells that may be resisting apoptosis or exhibiting survival advantages?", "Can you identify features that could be associated with altered growth factor signaling or disrupted intercellular communication?", "Is there evidence of metastatic spread, such as abnormal cell clusters present in distant organs or tissues?", "Does the image show signs of cachexia or systemic metabolic effects, such as tissue wasting or loss of normal tissue mass?"]}, "no_questions": {"contexual_properties": ["Is there visible scaling or flaking that could be due to dermatitis, psoriasis, or eczema?", "Does the image show any evidence of swelling that could indicate underlying inflammation or trauma?", "Can you observe discoloration that might suggest bruising or hyperpigmentation?"], "properties": ["Does the image have a pixel density that appears to be in the range of 200 to 400 pixels per inch?", "Is the aspect ratio of the image consistent with standard values like 4:3 or 16:9?", "Does the brightness of the image seem to fall within the range of 150 to 250 cd/m\u00b2?"], "relational": ["Can you identify features belonging to the integumentary or musculoskeletal systems in the image?", "Are tissues such as the epidermis, dermis, subcutaneous tissue, or facial muscles apparent in the image?", "Are the posterior head, neck, or ears excluded from the visible region in the image?"], "contexual_behavior": ["Does the image enhance the visibility of vascular patterns, possibly indicating facial erythema or edema from an allergic reaction?", "Does the image reveal changes in facial expression or muscle tone that could be associated with emotional stress?", "Is there reduced clarity of facial contours, potentially caused by tissue swelling or edema?"], "functions": []}}, "intrauterine contraceptive device": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image contain a device located within the uterine cavity?", "Is there a visible object that could serve as a contraceptive by being placed inside the uterus?", "Can you identify a structure that is not a natural anatomical part but is present within the uterus?", "Does the image show a foreign object whose presence suggests a method of birth control?"], "relational": ["Does the image show an internal foreign object located within the female reproductive system?", "Is there a structure present inside the uterine cavity?", "Can you identify an object that is in direct contact with the endometrial lining or uterine mucosa?", "Does the image contain a foreign body positioned in the fundus or body region of the uterus?", "Is there evidence of an object that has been inserted through the cervix and now resides superior to it?", "Can you see a structure that interacts anatomically with the endometrial cavity?", "Is there an object whose placement is separated from other pelvic organs by the uterine wall or peritoneum?", "Does the image show a foreign object adjacent to the fallopian tubes or ovaries?", "Can you identify something that would have traversed the vaginal and cervical canal to reach its current position?", "Is there a structure within the uterus that is not a native anatomical part?"], "contexual_behavior": ["Is there a device present that could lose its ability to prevent implantation if it is not fully within the uterine cavity?", "Can you identify an object that might trigger a local inflammatory response shortly after being placed inside the uterus?", "Does the image show a device whose effectiveness at inhibiting sperm movement depends on its correct position within the uterus?", "Is there a structure whose contraceptive efficacy could be altered in the presence of uterine infection or endometrial inflammation?", "Can you see a device that would impair endometrial receptivity more during the proliferative phase of the menstrual cycle?", "Is there evidence of a device that could become less effective if it is partially or completely expelled from the uterus?", "Does the image contain a structure that might be associated with increased menstrual bleeding in the months following its insertion, especially if it contains copper?", "Is there a device visible that could reduce its function after long-term use due to biofilm formation or degradation?", "Can you identify an object whose contraceptive action might fail in the presence of enzyme-inducing medications, particularly if it releases hormones?", "Is there a device that could enhance its contraceptive effect during the luteal phase due to increased endometrial changes?", "Does the image show a structure whose function may be impaired in the presence of uterine anomalies such as a septate or bicornuate uterus?", "Is there an object that could increase the risk of pelvic inflammatory disease, especially within the first 20 days after its placement?", "Can you see a device that decreases sperm viability more effectively if it contains copper?", "Is there a structure whose local hormone release might be altered under metabolic stress, potentially affecting the release rate of levonorgestrel?", "Does the image show a device that would lose its contraceptive effect if it is completely expelled from the uterine cavity?"], "functions": ["Does the image show a device that serves to prevent pregnancy by interfering with fertilization or implantation?", "Can you identify an object that inhibits sperm movement or alters the endometrial environment?", "Is there a structure present that could induce local inflammation or modify the uterine lining?", "Does the image contain a device that might reduce sperm motility or decrease sperm survival within the uterus?", "Can you see an object that creates a barrier to sperm and ova interaction, thereby inhibiting fertilization?", "Is there evidence of a device that could disrupt endometrial receptivity and prevent implantation?", "Does the image show something that could enhance local immune responses, such as increasing leukocyte activity in the uterus?", "Can you identify a structure that might release hormones or copper ions to locally inhibit reproductive processes?", "Is there a device present that could thicken cervical mucus and block sperm penetration?", "Does the image contain an object that could cause morphological or biochemical changes in the uterine lining, reducing its receptivity?"]}, "no_questions": {"contexual_properties": ["Is there evidence of increased fluid accumulation at a site of acute inflammation or infection?", "Is there a clear, watery fluid present that might be associated with mild inflammation or early tissue injury?", "Is there any indication that the fluid's properties might have changed due to bacterial metabolism, cellular breakdown, or alterations in the local tissue environment?"], "properties": ["Does the image contain a substance that appears to have a high density or specific gravity?", "Can you identify any material that could have a low lipid content, unless it appears chylous?", "Can you see any material that might form fibrinous strands or clots?"], "relational": ["Is there evidence of abnormal fluid accumulation in the lungs, joints, peritoneum, pleura, or skin?", "Does the image display changes in serous, synovial, or mucous membranes that could indicate fluid buildup?", "Does the image suggest the presence of a protein-rich, cell-containing fluid rather than a clear, low-protein transudate?"], "contexual_behavior": ["Can you observe differences in fluid appearance or composition that might reflect varying immune responses to different pathogens?", "Is there evidence of excessive or persistent fluid that might impair tissue healing, especially in the context of an immunocompromised state?", "Is there evidence of excessive fluid in the pleural space, suggesting pleural effusion due to inflammation or infection?"], "functions": ["Does the image show evidence of tissue repair, such as a fluid that might be supplying growth factors or supporting regeneration?", "Does the image suggest the presence of a substance that could be reducing tissue viscosity and forming chemotactic gradients for white blood cell migration?", "Is there a feature that might be delivering nutrients such as proteins, glucose, or electrolytes to damaged tissues?"]}}, "prostate": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears enlarged, as might be seen in benign growths or malignant tumors?", "Can you identify an organ that appears shrunken, possibly due to hormonal therapy or age-related changes?", "Is there a structure with altered texture, which could indicate malignancy, chronic inflammation, or fibrotic changes?", "Does the image reveal an area that appears firmer than surrounding tissue, suggestive of cancer, fibrosis, or chronic inflammation?", "Can you see a region that looks softer, which might be associated with acute inflammation or abscess formation?", "Is there evidence of nodular formations that could be related to benign hyperplasia or neoplastic processes?", "Does the structure display an irregular or asymmetric shape, possibly due to unilateral nodules, tumors, or cysts?", "Are there visible calcifications within a glandular structure, which might result from chronic inflammation, aging, or prior infection?", "Can you identify signs of inflammation, such as swelling or redness, that could indicate an infectious or inflammatory process?", "Is there a change in color within the tissue, potentially due to hemorrhage, necrosis, or inflammation?", "Does the organ appear heavier or bulkier, as might occur in benign hyperplasia or neoplastic growth?", "Is there evidence of decreased size or weight, which could be due to atrophy, hormonal therapy, or aging?", "Can you see cystic areas that may have formed from ductal obstruction or congenital anomalies?", "Is there abnormal tissue composition, such as areas of irregular density or structure, possibly indicating cancer, inflammation, or fibrosis?", "Does the structure show increased vascularity, which might be associated with malignancy or chronic inflammation?", "Are there regions of necrosis visible, as could occur in advanced cancer or severe infection?", "Can you identify areas with increased cellularity, suggestive of hyperplasia or malignancy?", "Does the tissue appear less elastic, which may be due to fibrosis, chronic inflammation, or aging?"], "properties": ["Is there a structure in the image that measures approximately 3 cm in height, 4 cm in width, and 2 cm in depth?", "Can you identify an object with an average weight of about 20 to 30 grams?", "Does the image show a chestnut-shaped or rounded-conical structure?", "Is there a grayish-white anatomical entity present?", "Can you see a structure with a volume around 20 to 30 milliliters?", "Is there an object that appears firm and rubbery in texture?", "Does the image contain a structure composed of secretory epithelial cells, basal cells, neuroendocrine cells, and stromal cells?", "Can you identify an anatomical entity with approximately 80% water content by weight?", "Is there a structure with a density close to 1.05 grams per cubic centimeter?", "Does the image show an object that would have a slightly acidic pH, typically between 6.4 and 6.7?", "Is there a structure known for high zinc concentration, ranging from 1,000 to 3,000 micrograms per gram of tissue?", "Can you see an anatomical entity with elevated citrate levels, typically 40 to 150 millimoles per kilogram?", "Is there a structure with a calcium concentration of about 1 to 2 milligrams per gram of tissue?", "Does the image contain an object whose protein content is approximately 10 to 15% of its wet weight?", "Can you identify a structure that produces enzymes such as prostate-specific antigen, acid phosphatase, or kallikrein-related peptidases?", "Is there an anatomical entity with a PSA concentration around 0.5 to 2 micrograms per gram?", "Does the image show a structure divided into five lobes: anterior, posterior, median, and two lateral lobes?", "Can you see an object with a lipid content of about 2 to 5% of its wet weight?", "Is there a structure with a temperature close to 37\u00b0C?", "Does the image contain an anatomical entity where connective tissue comprises about 30% of its total volume?"], "relational": ["Does the image show a structure that is part of the male reproductive system?", "Can you identify an organ located near the bladder and rectum?", "Is there a structure adjacent to the seminal vesicles?", "Does the image contain a region connected to the ejaculatory ducts?", "Can you see an area where the urethra passes through an organ, forming a distinct passage?", "Is there evidence of anatomical support from pelvic floor muscles or puboprostatic ligaments for a structure in the image?", "Does the image display zones such as peripheral, central, or transitional regions within a single organ?", "Can you identify a structure that receives blood supply from the inferior vesical artery or middle rectal artery?", "Is there an organ in the image associated with the internal pudendal artery?", "Does the image show a region containing glandular epithelium, fibromuscular stroma, or connective tissue?", "Can you see a structure that interacts with both the seminal vesicles and the vas deferens during ejaculation?", "Is there an organ in the image that is anatomically related to the bulbourethral glands?", "Does the image contain a structure that forms part of the urethral passage?"], "contexual_behavior": ["Is there a structure in the image that increases its secretory activity during sexual stimulation?", "Can you identify an object whose contribution to semen volume would decrease after surgical removal or in cases of androgen deficiency?", "Does the image show a gland that may fail to support sperm motility effectively in the presence of chronic inflammation?", "Is there a structure that would increase inflammatory mediator production during prostatitis?", "Can you see an object that might decrease its function due to aging and reduced androgen levels?", "Is there a gland in the image that could show enlargement and altered secretion in benign prostatic hyperplasia?", "Does the image contain a structure that would increase its metabolic activity during malignant transformation?", "Can you identify an object that reduces zinc secretion under chronic inflammation or malignancy?", "Is there a structure that may fail to regulate the pH of seminal fluid in cases of infection or gland dysfunction?", "Can you see an object whose function is altered in response to fluctuations in testosterone or dihydrotestosterone?", "Is there a gland that would decrease its secretory output after hormone therapy or castration?", "Does the image show a structure that may exhibit reduced function following surgical intervention such as transurethral resection?", "Is there an object that increases immune cell infiltration and changes its secretion composition during acute infection?", "Can you identify a structure that fails to maintain normal seminal viscosity in disease states like chronic inflammation or malignancy?"], "functions": ["Does the image show a structure that produces a fluid essential for supporting sperm motility?", "Is there an object present that contributes a slightly alkaline secretion to semen?", "Can you identify a structure that plays a role in male fertility by providing nutrients and enzymes to enhance sperm viability?", "Does the image contain something that surrounds the urethra and helps regulate the flow of urine?", "Is there a visible structure that produces a fluid containing enzymes, zinc, and citric acid?", "Can you see an object that releases substances to activate and protect sperm cells during ejaculation?", "Is there a structure present that secretes antimicrobial agents and buffering substances to protect sperm from acidic environments?", "Does the image include a gland that responds to androgens such as testosterone and dihydrotestosterone?", "Can you identify a component of the male reproductive system that facilitates ejaculation and supports sperm health?", "Is there a structure that influences the pH of seminal fluid by secreting alkaline substances to optimize sperm survival?"]}, "no_questions": {"contexual_properties": ["Is there evidence of calcification in a tube next to the ovary, possibly following chronic inflammation or previous tubal infections?", "Is there abnormal tissue growth in a tube near the ovary, which could be due to endometriosis or neoplastic transformation?", "Can you observe cystic changes in a tube adherent to the ovary, as seen in hydrosalpinx or chronic salpingitis?"], "properties": ["Does the image show a structure with a length of approximately 10 to 12 centimeters and a diameter of 1 to 4 millimeters?", "Does the image include a structure with moderate vascularity and a rich capillary network?", "Can you see an object with high water content, approximately 70% by weight?"], "relational": ["Does the image show a structure located near the ovary, uterus, urinary bladder, or rectum within the pelvic region?", "Can you see a tube that is anatomically connected to both the ovary and the uterus?", "Does the image contain a structure that is supported by tissues such as the mesosalpinx or serosal layers?"], "contexual_behavior": ["Is there evidence of a tube-like structure with narrowed or blocked lumen, suggesting possible impairment of fertilization due to inflammation or fibrosis?", "Can you see a tube whose fimbrial end appears restricted or adherent, potentially reducing its ability to pick up oocytes after ovulation?", "Is there a structure present that, if its patency or function is compromised, could increase the risk of ectopic implantation due to embryo retention?"], "functions": ["Can you observe restricted movement of fimbriae or impaired access to the ovary, possibly interfering with ovum capture?", "Is there a structure visible that appears to be attached to an adjacent ovary, potentially affecting the capture and transport of an egg toward the uterus?", "Can you see any indication of mechanical obstruction or altered function in a tube that could lead to infertility?"]}}, "obvious lesion": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears larger, suggesting active cellular proliferation or ongoing inflammation?", "Can you identify an area that seems to have decreased in size, possibly indicating a response to treatment or natural healing?", "Does the image show a region with a noticeable color change, which could be due to altered vascularity, melanin content, or hemorrhage?", "Is there a raised area that might be explained by edema, cellular infiltration, or neoplastic growth?", "Can you see a surface breakdown or ulceration that could result from necrosis, trauma, or infection?", "Is there a region that appears firmer than surrounding tissue, possibly due to fibrosis, calcification, or tumor infiltration?", "Does the image contain a softer area that could be the result of liquefaction, cystic degeneration, or abscess formation?", "Is there a structure with an irregular shape, suggesting uneven growth or infiltration into adjacent tissues?", "Can you observe a border change in any area, which might be caused by malignant transformation or inflammatory processes?", "Is there a region that appears more pigmented, potentially due to increased melanin production or pigment deposition?", "Does the image show an area with loss of pigmentation, possibly indicating melanocyte destruction or regression?", "Is there a visibly inflamed region, which could be due to immune activation or secondary infection?", "Can you identify an area with increased exudate, suggesting higher vascular permeability or infection with pus formation?", "Is there evidence of tissue necrosis, such as a darkened or dead area, possibly resulting from compromised blood supply or rapid cell death?", "Does the image show surface crusting, which could be caused by dried exudate or coagulated blood?", "Is there a region that appears to bleed easily, perhaps due to increased vascular fragility or disruption of the surface epithelium?", "Can you see an indurated area, indicating tissue hardening from chronic inflammation or fibrosis?", "Is there a noticeable change in texture in any region, which could be due to modifications in cellular composition or the extracellular matrix?", "Are there smaller lesions near a primary abnormal area, suggesting malignant or infectious spread to adjacent skin?", "Does the image show changes in the composition of a region, such as alterations in cellular, stromal, or vascular elements, possibly due to disease progression?"], "properties": ["Is there a structure in the image that measures more than 5 millimeters in diameter?", "Can you identify an area with an irregular or asymmetrical shape compared to surrounding tissue?", "Does the image show a region that appears red, pale, or darker than the adjacent tissue?", "Is there a visible area that seems to extend from the surface layer into deeper tissue layers?", "Can you see a region with a rough, ulcerated, or nodular surface texture?", "Is there an area that appears firm, indurated, or possibly soft in consistency?", "Does the image contain a region with a well-defined or raised border that stands out from nearby tissue?", "Can you identify an area that might be warmer than the surrounding tissue, suggesting increased temperature?", "Is there a structure that is either elevated above or depressed below the level of the adjacent tissue?", "Does the image show a region with increased or decreased moisture, such as a moist or dry surface?", "Can you see an area with an irregular, ulcerated, or crusted surface appearance?", "Is there a structure whose volume appears larger than 0.1 cubic centimeters?", "Can you identify a region that is firm to touch, or possibly soft if cystic or necrotic changes are present?", "Does the image show an area with uniform or variegated pigmentation, including zones of increased or decreased color?", "Is there a region with visible blood vessels, increased vascularity, or evidence of bleeding?"], "relational": ["Does the image show an area within epithelial, connective, muscle, or nervous tissue that appears different from the surrounding tissue?", "Can you identify a region affecting the skin, liver, lung, colon, or breast that stands out from adjacent structures?", "Is there a distinct area located in the head and neck, thorax, abdomen, or limbs that appears abnormal?", "Can you see a region that is surrounded by healthy tissue, blood vessels, nerves, or extracellular matrix?", "Does the image contain a focus where inflammatory cells, neoplastic cells, fibroblasts, or endothelial cells might be present?", "Is there a structure that could impact the integumentary, digestive, respiratory, or nervous system?", "Can you identify an area where the continuity between itself and the adjacent healthy tissue is disrupted, possibly showing signs of inflammation, edema, or tissue damage?", "Does the image reveal a region with clear anatomical boundaries such as margins, a capsule, or a zone of demarcation?", "Is there an area that appears to be connected to other body structures via lymphatic vessels, blood vessels, or nerve fibers?", "Can you see a component within an organ, organ system, or body region that appears visually distinct from its surroundings?"], "contexual_behavior": ["Is there a region in the image where tissue damage appears extensive or located in a critical area, potentially leading to severe functional impairment?", "Can you identify an area that might heal more slowly due to signs of poor blood supply, advanced age, or evidence of chronic disease?", "Does the image show a site where protective barriers seem disrupted, possibly increasing the risk of infection?", "Is there evidence of inflammation, such as swelling or redness, that might indicate altered cellular signaling or dysfunction?", "Can you see a region where persistent injury could result in fibrosis or loss of normal tissue, potentially interfering with organ function?", "Is there an area that appears pale or poorly perfused, suggesting failed regeneration due to ischemia?", "Does the image reveal a site that might elicit a stronger pain response if exposed to cold, pressure, or chemical irritants?", "Is there visual evidence of exaggerated or suppressed inflammation that could indicate altered immune response during systemic illness?", "Can you identify a wound that may be healing poorly, possibly due to diabetes-related microvascular complications?", "Does any region appear to be becoming less visible or changing in appearance, suggesting ongoing tissue repair and remodeling?", "Is there a site that looks prone to increased bleeding, which could be associated with impaired clotting mechanisms?", "Can you see an area where the wound edges fail to approximate, possibly due to persistent mechanical stress?", "Is there evidence of abnormal scar formation, such as excessive fibrous tissue or irregular texture, following injury?", "Does the image show compromised epithelial integrity that could facilitate pathogen entry and reduce barrier function?", "Is there a lesion that appears to resolve slowly, which might be due to impaired immune cell activity in an immunocompromised state?"], "functions": ["Does the image show an area where normal tissue structure appears disrupted, potentially leading to impaired function?", "Can you identify a region where cellular architecture is altered, possibly interfering with organ-specific activities?", "Is there evidence of tissue damage that might hinder cell regeneration or metabolic exchange?", "Does the image contain a region where local blood flow could be compromised, suggesting vascular injury or edema?", "Can you see signs of inflammation, such as immune cell infiltration or tissue swelling, in any area?", "Is there a region where tissue repair seems impaired, possibly indicating fibrosis or delayed healing?", "Does the image show an area that might be attracting immune cells or associated with increased cytokine activity?", "Can you identify a region where cellular signaling could be disrupted due to tissue damage?", "Is there an area that might reduce the overall function of the organ or system it belongs to?", "Does the image show a region that could be associated with pain sensation or altered sensory input?", "Is there evidence of ongoing or accelerated disease progression, such as chronic inflammation or further tissue damage?", "Can you see an area where the tissue barrier appears compromised, potentially increasing susceptibility to infection or fluid loss?"]}, "no_questions": {"contexual_properties": ["Are there new brain regions showing accumulation of deposits, suggesting regional spread along neural pathways?", "Are there regions where aggregates appear more widespread, consistent with the progression of neurodegenerative conditions?", "Do any of the deposits display color changes on staining, which could indicate biochemical or structural modifications?"], "properties": [], "relational": ["Are there anatomical relationships to structures such as the spinal cord, brainstem, or thalamus?", "Can you see any changes near barriers or membranes like the blood-brain barrier, pia mater, or arachnoid mater?", "Can you identify changes in regions such as the cerebral cortex, hippocampus, or basal ganglia?"], "contexual_behavior": [], "functions": ["Are there features consistent with disrupted neuronal signaling or synapse loss?", "Does the image reveal features associated with neurodegeneration, such as neuronal loss or chronic inflammation?", "Can you see signs of homeostatic imbalance, such as altered cellular metabolism or oxidative stress in neural tissue?"]}}, "obvious lesion primary in prostate": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure located within the male reproductive system that appears abnormal?", "Is there a visible abnormality in the pelvic cavity region?", "Can you identify a lesion adjacent to the seminal vesicles, bladder, or rectum?", "Does the image reveal an area of altered glandular epithelium or fibromuscular stroma?", "Is there a region within the peripheral, central, or transitional zones that appears different from surrounding tissue?", "Can you see an abnormality involving the prostatic or ejaculatory ducts?", "Is there evidence of changes in the area supplied by the inferior vesical artery or drained by the prostatic venous plexus?", "Does the image show lymphatic involvement near the obturator or internal iliac lymph nodes?", "Is there a lesion in close proximity to the urinary bladder, rectum, or seminal vesicles?", "Can you identify an abnormality that might affect the lower urinary tract?"], "contexual_behavior": [], "functions": ["Does the image show a region with disrupted tissue structure or abnormal cellular proliferation within a glandular organ?", "Is there evidence of a lesion that could cause urinary symptoms such as hesitancy or a weak stream by compressing the urethra?", "Can you identify an area that might interfere with local hormone signaling or androgen metabolism?", "Does the image reveal a region that could impair seminal fluid production and potentially affect fertility?", "Is there a visible lesion that appears to invade local tissues, suggesting the possibility of extracapsular extension or involvement of nearby structures?", "Can you see any sign of partial or complete obstruction of the prostatic urethra that might lead to urinary retention?", "Is there an area where the composition or amount of glandular secretions could be decreased or altered?", "Does the image show changes in cellular architecture, vascular supply, or secretory function within a glandular structure?", "Is there evidence of local inflammation, such as immune cell infiltration or regions suggestive of cytokine release?", "Can you identify a lesion that appears to invade or compress adjacent organs such as the bladder, seminal vesicles, or rectum?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you observe any asymmetry or overgrowth affecting the limbs?", "Does the image reveal visceromegaly involving abdominal organs?", "Are there visible features of organomegaly in the abdomen?"], "contexual_behavior": [], "functions": ["Can you see indications of abnormal insulin secretion or altered endocrine function?", "Is there evidence of increased cell proliferation or tissue hyperplasia?", "Does the image suggest the presence of visceromegaly or macroglossia?"]}}}
[ { "answer": "an apocrine cyst", "extracted_concepts": [ "nonproliferative breast disease", "apocrine cyst" ], "question": "what is shown that is a common feature of nonproliferative breast disease?" }, { "answer": "a common feature of nonproliferative breast disease", "extracted_concepts": [ "nonproliferative breast disease", "breast disease", "apocrine cyst" ], "question": "what is an apocrine cyst?" }, { "answer": "yes", "extracted_concepts": [ "nonproliferative breast disease", "apocrine cyst" ], "question": "is an apocrine cyst a common feature of nonproliferative breast disease?" }, { "answer": "no", "extracted_concepts": [ "nonproliferative breast disease", "prominent cell" ], "question": "is the prominent cell in the center field a common feature of nonproliferative breast disease?" } ]	["nonproliferative breast disease", "breast disease", "prominent cell", "apocrine cyst"]	{"nonproliferative breast disease": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a lesion with cyst formation or fibrosis?", "Can you identify areas with mild ductal ectasia?", "Is there evidence of structures composed of epithelial cells, myoepithelial cells, or stromal fibroblasts?", "Does the lesion appear to be a few millimeters to several centimeters in size?", "Are there cysts with flattened epithelium visible under magnification?", "Can you see regions of dense stroma with minimal cellular atypia?", "Is the tissue architecture characterized by dilated ducts or cystic spaces?", "Do you observe increased fibrous tissue in the sample?", "Does the tissue appear to have low to moderate density?", "Is the color of the lesion white to tan, or are there translucent areas suggestive of cystic regions?", "Can you identify areas with moderate to high water content, especially within cystic spaces?", "Is there evidence of increased collagen due to stromal fibrosis?", "Does the fat content appear similar to normal breast tissue or only slightly reduced?", "Are calcifications infrequent or scattered within the lesion?", "Can you see a single cyst or multiple cysts present in the tissue?", "Is the epithelial cell morphology flattened or cuboidal with minimal atypia?", "Does the lesion display a low mitotic index?", "Are the nuclei of the cells low grade or grade 1 in appearance?"], "relational": ["Does the image show changes affecting the epithelial or stromal tissues within the breast?", "Can you identify alterations involving the terminal duct lobular units, ducts, or surrounding connective tissue?", "Is there evidence of lesions located in the upper outer quadrant or subareolar region of the breast?", "Does the image display any abnormalities in the ducts or lobules of the mammary glands without signs of increased cellular proliferation?", "Can you see features that are part of the female reproductive system?", "Are there visible lesions such as cysts, fibroadenomas, or areas suggestive of simple ductal hyperplasia?", "Does the image reveal changes involving the terminal ducts or lobules?", "Is there evidence of involvement of fibrous stroma or adipose tissue in the breast?", "Can you identify any interaction between the lactiferous sinuses and the surrounding adipose tissue in the affected area?", "Does the image lack signs of increased epithelial cellularity or proliferation in the observed breast tissue?"], "contexual_behavior": [], "functions": ["Does the image show breast tissue with benign changes but no evidence of increased cellular proliferation?", "Can you identify areas in the breast that display cyst formation or mild fibrosis without significant disruption of normal tissue structure?", "Is there evidence of cystic remodeling or localized fluid accumulation within the breast tissue?", "Does the glandular tissue in the breast appear to have preserved secretory function and normal milk production?", "Can you see any signs that suggest the hormonal sensitivity of the breast tissue, such as estrogen or progesterone response, remains unchanged?", "Is there visual evidence of mild ductal changes without active tissue turnover or significant remodeling?", "Does the image show breast tissue with minimal or absent inflammatory response, indicating little immune activation?", "Can you observe features suggesting that healing and inflammatory processes in the breast tissue are typical and not significantly altered?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display features consistent with a sagittal, midsagittal, or parasagittal plane?", "Is there a visible division of larger structures such as brain hemispheres or the vertebral column?", "Can you see anatomical continuity from superior to inferior regions within the sample?"], "contexual_behavior": ["Can you detect diminished nucleic acid integrity, such as poor DNA or RNA staining, that could be caused by acidic fixatives?", "Does the tissue architecture appear disrupted, suggesting autolysis or degradation from delayed fixation after harvest?", "Can you see decreased visualization of specific proteins, possibly due to exposure to high temperatures that denature protein epitopes?"], "functions": ["Is there visual information that could be used to compare normal and abnormal tissue features within a defined anatomical context?", "Does the image reveal how cell populations are distributed across different tissue layers?", "Is there evidence of neural tracts or pathways that could be mapped within the central nervous system?"]}}, "breast disease": {"yes_questions": {"contexual_properties": ["Does the image show tissue enlargement that could be due to gynecomastia, mastitis, or a tumor?", "Is there visible swelling that might suggest inflammation, infection, or malignancy?", "Can you observe any color changes, such as redness or bruising, that could indicate inflammation or a vascular disorder?", "Does the image reveal any lumps that might represent a benign mass, malignant tumor, cyst, or fibroadenoma?", "Is there an area that appears firmer, possibly due to fibrosis, tumor infiltration, or chronic inflammation?", "Can you see any dimpling of the skin that might be caused by underlying malignancy, as seen in peau d\u2019orange?", "Is there evidence of nipple retraction that could be due to a tumor or fibrosis?", "Does the tissue appear denser, which might be related to fibrocystic changes, hormonal stimulation, or neoplasia?", "Can you identify any abnormal discharge that could be associated with infection, duct ectasia, or an intraductal tumor?", "Is there increased vascularity, possibly indicating inflammation or rapid tumor growth?", "Does the area appear painful to touch, as might be suggested by signs of inflammation, infection, or trauma?", "Is there any ulceration present that could result from a malignant tumor invading the skin or a severe infection?", "Can you detect calcifications that might be due to fat necrosis or malignancy?", "Are there noticeable changes in texture, such as edema, fibrosis, or involvement of the skin by a tumor?", "Does the image show redness or warmth that could be associated with acute mastitis or inflammatory breast cancer?", "Is there evidence of volume loss that might follow atrophy, surgery, or radiation therapy?", "Can you observe any thickening of the skin that could result from lymphedema, inflammation, or tumor infiltration?", "Are there cystic changes visible, possibly due to fibrocystic alterations or benign cyst formation?", "Does the image display abnormal findings such as a mass, calcification, or architectural distortion?", "Is there any sign of tissue necrosis that could be caused by severe infection, abscess, or advanced malignancy?"], "properties": ["Does the image show a lesion that is most likely to occur in adults between the ages of 30 and 70?", "Can you identify any areas with epithelial proliferation or fibrosis?", "Is there evidence of inflammatory infiltrates or cellular atypia within the tissue?", "Does the image reveal a mass or lesion measuring between 1 millimeter and 5 centimeters?", "Are there visual features such as masses, calcifications, architectural distortion, or asymmetry present?", "Can you observe any changes that might have developed over several weeks to months?", "Is there a region containing a mix of epithelial, stromal, inflammatory, or myoepithelial cells?", "Does the image suggest that hormone receptor status, such as estrogen or progesterone positivity, could be relevant for this lesion?", "Can you assess whether the pathological grade of the lesion appears to be low, intermediate, or high?", "Is there an indication of a low or high mitotic index within the lesion?", "Does the image suggest a molecular subtype such as luminal A, luminal B, HER2-enriched, or triple negative?", "Are there features that might be associated with genetic alterations in BRCA1, BRCA2, TP53, or PIK3CA?", "Is the density of the affected tissue higher than what would be expected in normal breast tissue?", "Does the lesion appear to have increased vascularity compared to surrounding tissue?", "Can you infer whether the growth rate of the lesion is slow or rapid based on its appearance?"], "relational": ["Does the image show any abnormality affecting a structure that is part of both the integumentary and reproductive systems?", "Is there evidence of changes involving the mammary glands, ducts, lobules, or nipple?", "Can you identify alterations in glandular, adipose, or connective tissue within the depicted region?", "Does the image display any involvement of the breast, axilla, or chest wall?", "Are there visible changes in lymphatic structures such as the axillary, internal mammary, or supraclavicular lymph nodes?", "Can you see any relationship between the affected area and nearby organs like the skin, pectoral muscles, or ribs?", "Is there evidence of abnormality in cell types such as epithelial cells, myoepithelial cells, adipocytes, or immune cells?", "Does the image reveal any changes in the lactiferous ducts, terminal duct lobular units, or major lobules?", "Is there any sign of invasion or alteration of the pectoralis major muscle or the overlying skin?", "Can you identify involvement of vascular structures such as the internal thoracic artery, lateral thoracic artery, or intercostal veins in the affected area?"], "contexual_behavior": ["Does the image show evidence of a process that could disrupt the secretion of milk, such as inflammation or abnormal tissue growth?", "Is there a visible indication of impaired immune defense in breast tissue, possibly due to inflammation or malignancy?", "Can you identify features suggesting altered hormone responsiveness in breast cells, such as the presence of hormone receptor-positive tumors?", "Does the image display signs of increased inflammatory activity in the breast, such as swelling or redness that could indicate infection or chronic inflammation?", "Is there evidence of disrupted tissue repair in the breast, such as scarring or fibrosis?", "Can you see any indication of decreased structural support in breast tissue, possibly due to invasive growth or connective tissue degradation?", "Does the image reveal signs of impaired lymphatic drainage, such as swelling or edema that might result from tumor or fibrosis?", "Is there visual evidence of abnormal cell proliferation, such as masses or thickened areas that could represent benign or malignant growth?", "Can you identify features suggesting reduced ability of the breast to respond to injury, such as chronic disease or visible scarring?", "Does the image show changes in metabolic activity of breast cells, such as areas of altered density that might indicate neoplastic transformation or inflammation?", "Is there evidence of failure of normal programmed cell death, such as persistent abnormal tissue that could result from genetic mutations or oncogenic processes?", "Can you see signs that might indicate increased susceptibility to infection in the breast, such as tissue changes associated with immunosuppression or trauma?", "Does the image suggest a decreased response to hormonal changes during the menstrual cycle, possibly due to altered hormone receptor function?", "Is there evidence of impaired healing after trauma, such as persistent inflammation, infection, or abnormal tissue in the breast?", "Can you identify alterations in the vascular supply to breast tissue, such as compressed or invaded blood vessels?", "Does the image show features that could indicate reduced capacity for lactation after childbirth, such as damage to glandular tissue?", "Is there visual evidence of increased oxidative stress in breast tissue, such as changes associated with inflammation or neoplastic processes?", "Can you see signs of disrupted signaling between breast cells, such as irregular tissue patterns that might result from mutations or tumor growth?", "Does the image reveal impaired removal of cellular waste from breast tissue, such as swelling that could be due to compromised lymphatic or vascular drainage?", "Is there evidence that the breast\u2019s response to environmental toxins might be altered, such as tissue changes linked to genetic alterations, inflammation, or neoplasia?"], "functions": ["Does the image show evidence of functional impairment in a structure associated with lactation, such as swelling or altered tissue architecture?", "Can you identify any signs of decreased milk production or obstruction of glandular ducts in the relevant area?", "Is there visual evidence suggesting disruption of hormonal regulation, such as changes that might indicate altered estrogen or progesterone receptor activity?", "Does the image reveal any features consistent with abnormal immune responses, such as chronic inflammation or increased susceptibility to infection in the tissue?", "Can you observe any disruptions in normal tissue remodeling, such as an imbalance between cell proliferation and apoptosis?", "Is there a visible change in texture, lump formation, or alteration in the appearance of the skin or nipple?", "Does the structure in question show signs of compromised barrier function, such as increased risk of infection or tissue damage?", "Can you see localized redness, warmth, or swelling that might indicate an enhanced inflammatory process?", "Is there evidence of abnormal cell growth, impaired apoptosis, or possible tumor formation in the tissue?", "Does the image suggest obstruction of lymphatic drainage, such as swelling or lymphedema in the breast or surrounding areas?"]}, "no_questions": {"contexual_properties": ["Can you identify a region that appears distinct from surrounding tissue and may suggest secondary involvement by a pathological process?", "Is there a visible lesion that differs in appearance from normal tissue and could represent a distant manifestation of a primary condition elsewhere in the body?", "Does the image show any abnormal area that could indicate the spread of disease from another primary site?"], "properties": [], "relational": ["Does the image show an abnormality within the skeletal, respiratory, hepatic, or nervous systems?", "Can you identify a lesion in the bone, liver parenchyma, lung parenchyma, brain tissue, or lymph nodes?", "Can you identify a mass or lesion that appears to have formed through hematogenous or lymphatic spread, or by direct extension?"], "contexual_behavior": ["Does the image contain any structures that look atypical or out of place relative to normal anatomy?", "Does the image show an area that could represent abnormal tissue growth distinct from surrounding structures?", "Is there a region that appears different in texture or color compared to adjacent tissues, suggesting a pathological process?"], "functions": ["Is there a region that appears resistant to therapy, such as persisting despite signs of treatment or showing features of survival advantage?", "Is there a visible mass that could represent a secondary site of tumor growth, distinct from the primary lesion?", "Is there evidence of a structure that could be causing local destruction or compromising the integrity of an organ?"]}}, "prominent cell": {"yes_questions": {"contexual_properties": ["Is there a cell in the image that appears enlarged, possibly due to hypertrophy, activation, or neoplastic transformation?", "Can you identify a cell that seems reduced in size, which might indicate atrophy, apoptosis, or senescence?", "Does the image show a cell with an altered shape, as might occur during differentiation, migration, or epithelial-mesenchymal transition?", "Is there a multinucleated cell present, suggesting cell fusion, viral infection, or muscle regeneration?", "Can you see a cell with abnormal inclusions, which could be related to storage diseases, viral infection, or protein aggregation disorders?", "Is there a cell that changes color with staining, possibly due to increased protein or nucleic acid content?", "Does the image reveal a cell with increased cytoplasmic granularity, as seen during activation, inflammation, or toxic injury?", "Is there a cell containing vacuoles, which might result from autophagy, degeneration, or exposure to toxins?", "Can you identify a cell with altered membrane features, potentially due to activation, malignancy, or infection?", "Is there a cell with an enlarged nucleus, which could indicate cell growth, malignancy, or viral infection?", "Does the image show a cell with abnormal chromatin patterns, as seen in neoplastic transformation, viral infection, or apoptosis?", "Is there a cell that appears more refractile under microscopy, possibly due to inclusions, protein aggregation, or cytoplasmic changes?", "Can you observe a cell with noticeably increased or decreased cytoplasmic volume, which might be due to hypertrophy, atrophy, or injury?", "Is there a cell displaying changes in surface markers, as would occur during differentiation, immune activation, or malignant transformation?", "Does the image contain a cell with accumulated lipid droplets, suggesting a metabolic disorder, steatosis, or toxic exposure?", "Is there a cell that appears more eosinophilic or basophilic, possibly due to changes in protein or nucleic acid content, or injury?", "Can you identify a cell with increased mitotic figures, as seen during rapid proliferation, neoplastic growth, or tissue regeneration?", "Is there a cell with abnormal structural features, which could be associated with congenital disorders, neoplasia, or injury?", "Does the image show a cell with altered organelle content, possibly reflecting metabolic adaptation, stress response, or disease?", "Can you see a cell exhibiting cytoplasmic or nuclear fragmentation, as might occur during apoptosis, necrosis, or other pathological processes?"], "properties": ["Can you identify a structure measuring between 10 and 30 micrometers in diameter?", "Is there a cell with a generally round or oval shape visible in the image?", "Does the image show a cell whose volume appears to be within the range of 500 to 4000 cubic micrometers?", "Can you see a cell that appears colorless or only lightly stained under the microscope?", "Is there a cell present with a nuclear-to-cytoplasmic ratio of approximately 1:2 to 1:4?", "Does the image contain a cell that has a single nucleus?", "Can you identify a cell with low to moderate cytoplasmic granularity?", "Is there a cell whose protein content could be estimated at about 10\u201320% of its wet weight?", "Does the image show a cell with a lipid content likely between 2\u20135% of its wet weight?", "Can you see a cell that might have a carbohydrate content of 1\u20132% of its wet weight?", "Is there a cell present that appears to have a water content around 70\u201385% of its total mass?", "Can you identify a cell that would be expected to contain approximately 6 picograms of DNA per diploid nucleus?", "Does the image show a cell with an RNA content estimated at 10\u201330 picograms per cell?", "Is there a cell whose surface area appears to be within the range of 300 to 2000 square micrometers?", "Can you see a cell that might contain between 100 and 1000 mitochondria?", "Is there a cell present with an average membrane potential of approximately \u201370 millivolts?", "Does the image show a cell whose cytoplasmic pH is likely around 7.2?", "Can you identify a cell that contains enzymes such as hydrolases, kinases, or oxidoreductases?", "Is there a cell present whose lifespan is likely to be several days to weeks?", "Can you see a cell with a density close to 1.05 grams per cubic centimeter?"], "relational": ["Does the image show any tissue that could be classified as epithelial, connective, or nervous?", "Can you identify a structure that is part of the nervous, immune, or muscular system?", "Is there evidence of specialized cells such as neurons, myocytes, or hepatocytes?", "Does the image contain anatomical features like muscle fibers, nerve bundles, or glandular tissue?", "Can you see cells interacting with the extracellular matrix through anchorage or providing structural support?", "Is there a visible organ such as the brain, heart, or liver?", "Are there cells in the image that appear to interact with fibroblasts, endothelial cells, or glial cells?", "Does the image show regions like the cerebral cortex, myocardium, or epidermis?", "Can you identify developmental origins such as neural tube, mesoderm, or endoderm derivatives in the structures present?", "Are there cells containing prominent subcellular features like a nucleus, mitochondria, or endoplasmic reticulum?"], "contexual_behavior": ["Is there a cell in the image that appears more active in regions showing signs of inflammation or tissue injury?", "Can you identify a cell whose activity seems diminished in areas with reduced oxygen supply or hypoxic conditions?", "Does the image show a cell that might be dysfunctional in the presence of a high pathogen load or microbial toxins?", "Is there evidence of a cell with increased metabolic activity in response to visible signs of cellular stress?", "Can you see a cell that appears less involved in tissue repair in regions affected by chronic inflammation?", "Is there a cell whose signaling behavior might be altered in areas exposed to environmental toxins or pollutants?", "Does the image contain a cell that could be functionally impaired due to an immune attack, as seen in autoimmune disease?", "Is there a cell that shows increased proliferation in regions undergoing tissue regeneration or repair?", "Can you identify a cell with a reduced immune response in tissues affected by chronic disease?", "Does the image show a cell that might be adapting to DNA damage or oxidative stress following radiation exposure?", "Is there evidence of a cell failing to maintain homeostasis in tissues showing signs of aging or cellular senescence?", "Can you see a cell that increases cytokine secretion in response to the presence of pathogens?", "Is there a cell with reduced defense mechanisms in areas where immunosuppressive drugs or regulatory cytokines might be present?", "Does the image show a cell that alters its metabolic pathways in regions where nutrient availability appears limited, such as during fasting?", "Can you identify a cell with impaired function in tissues showing signs of nutrient deficiency or malnutrition?"], "functions": ["Does the image show a cell that appears to be actively involved in metabolism or growth?", "Can you identify a cell that seems to provide structural support to the surrounding tissue?", "Is there evidence of a cell facilitating tissue repair or enabling communication with neighboring cells?", "Does the image contain a cell participating in signal transduction or nutrient transport?", "Can you see a cell that might be involved in waste removal from its environment?", "Is there a cell that appears to be activating receptors or secreting signaling molecules?", "Does the image show a cell maintaining homeostasis by regulating ion balance or controlling pH?", "Can you identify a cell that seems to be responding to injury or stress, such as by initiating repair pathways?", "Is there evidence of a cell releasing cytokines or undergoing apoptosis in response to stress?", "Does the image contain a cell contributing to immune defense, for example by presenting antigens or performing phagocytosis?", "Can you see a cell that appears to be remodeling the extracellular matrix or releasing growth factors?", "Is there a cell that seems to be migrating, proliferating, or differentiating within the tissue?", "Does the image show a cell interacting with other cell types through direct contact or paracrine signaling?", "Can you identify a cell that is part of a functional network with other cells?"]}, "no_questions": {"contexual_properties": ["Does the image demonstrate increased narrowing at the cranial base in a way that could be seen in syndromic craniosynostosis or skeletal dysplasia?", "Can you see signs of reduced cerebrospinal fluid flow at the cranial base, which might occur if the aperture is critically narrowed by bone overgrowth?", "Is there abnormal bone growth at the cranial base, as might be seen in fibrous dysplasia or bone tumors?"], "properties": ["Does the image display a constricted bony opening with thickened margins at the skull base?", "Can you observe compact and cancellous bone with abnormal thickening around a major cranial foramen?", "Is there a bony opening at the base of the skull with an anteroposterior diameter less than 19 mm?"], "relational": ["Does the image show a region where the medulla oblongata, vertebral arteries, or spinal accessory nerves would pass through a visibly restricted space?", "Can you identify a structure whose boundaries are formed by the occipital bone and appears constricted?", "Is there a narrowed passageway in the skull that could affect the vertebral arteries or anterior spinal artery?"], "contexual_behavior": [], "functions": ["Is there any indication of medullary center involvement that could interfere with respiratory regulation or cause breathing impairment?", "Does the image reveal any signs of impaired brainstem function, such as possible autonomic instability or cranial nerve dysfunction?", "Can you see any compromise of arterial or venous blood flow that might lead to ischemia or venous congestion in the brain?"]}}, "apocrine cyst": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure in the image that measures between 0.5 and 2 centimeters in diameter?", "Can you identify a round or oval-shaped lesion?", "Does the image show a cystic structure containing fluid that appears straw-colored or yellow?", "Is there evidence of a cavity with a fluid volume estimated between 0.1 and 2 milliliters?", "Can you see a cystic area with contents that look serous or slightly viscous?", "Is there a thin-walled cyst, with the wall thickness appearing to be about 0.1 to 0.5 millimeters?", "Does the fluid-filled structure seem to have a neutral to slightly alkaline environment, with a pH around 7.0 to 7.5?", "Is there a cystic lesion whose fluid is likely to have a low to moderate protein concentration, approximately 1 to 3 grams per deciliter?", "Can you identify a cyst lined by a single layer of cuboidal or columnar epithelial cells, possibly with myoepithelial cells present?", "Is there a fluid-filled cavity where the cholesterol content is likely to be low, typically less than 50 milligrams per deciliter?", "Does the cystic fluid appear to have a glucose level similar to plasma, about 70 to 100 milligrams per deciliter?", "Is there a structure that might contain fluid with a faint or mild odor?", "Can you see a cystic lesion where the fluid is likely to have a high water content, over 90 percent?", "Does the fluid in the cyst appear to have a density close to that of water, around 1.005 to 1.015 grams per milliliter?", "Is there evidence of a cyst lined by a single layer of apocrine epithelial cells, either cuboidal or columnar in shape?"], "relational": ["Does the image show a structure associated with the integumentary system?", "Can you identify an area containing both epithelial and connective tissue?", "Is there a lesion located near the dermis or subcutaneous tissue?", "Does the image include a feature related to apocrine glands?", "Can you see a cystic structure in regions such as the axilla, anogenital area, or areola?", "Is there a visible abnormality involving the dermis or epidermis?", "Does the image show a structure connected to apocrine ducts or pilosebaceous units?", "Is there a cystic lesion associated with the upper portion of a hair follicle?", "Can you identify a structure surrounded by a dermal matrix or connective tissue within the skin?", "Is there a cystic entity encompassed by cutaneous tissue?"], "contexual_behavior": ["Is there a cystic structure that might show increased secretory activity during periods of stress or anxiety?", "Can you identify a lesion that could produce more protein-rich fluid during puberty or menstrual cycles?", "Does the image show a cyst whose drainage might be impaired due to inflammation or ductal obstruction?", "Is there a structure that could have reduced fluid reabsorption if its epithelial lining is damaged?", "Can you see a cystic area that might fail to maintain its barrier function in the presence of infection or chronic irritation?", "Is there a lesion that could alter its secretion in response to infection by increasing inflammatory mediators?", "Does the image include a cystic structure that might decrease its secretory function in an older individual due to cellular senescence?", "Is there evidence of increased fluid accumulation in a cystic area that could be explained by recent trauma or tissue injury?", "Can you identify a cyst that might show reduced antimicrobial activity in an immunosuppressed patient?", "Is there a lesion that could fail to clear cellular debris in the context of chronic disease and persistent inflammation?", "Does the image show a cystic structure that might increase its secretion and inflammatory response during local skin irritation?", "Is there a cystic lesion that could become more active in response to endocrine disorders with elevated hormone levels?", "Can you see a cyst that might decrease its secretory output in a dehydrated individual?", "Is there a cystic structure whose function could be impaired due to duct blockage by keratin, debris, or inflammation?"], "functions": ["Does the image show a localized cavity containing accumulated fluid produced by secretory glands?", "Is there evidence of swelling or mild inflammation that could indicate disruption of local tissue physiology?", "Can you identify a structure that acts as a reservoir for secreted fluid, suggesting retention rather than normal excretion onto the skin surface?", "Does the image display any alteration in local moisture balance or features that might predispose to secondary infection?", "Is there visual evidence of a mild local immune response, such as chronic inflammation or recruitment of immune cells?", "Can you see any compression or distortion of nearby glandular structures that might affect their normal secretory function?", "Does the image contain a slowly growing, benign-appearing lesion with features suggesting a low risk of recurrence?", "Is there a structure that appears to obstruct glandular ducts and block normal secretion?"]}, "no_questions": {"contexual_properties": ["Is there a region in the image where elements are organized in a concentric or whorled manner?", "Does the image contain any tissue patterns that resemble a vortex or whirlpool shape?", "Does the image display any structures with a spiral or circular pattern?"], "properties": ["Is there a structure whose size could be measured in millimeters or centimeters and varies depending on tissue context?", "Can you find a pattern commonly seen in histological samples of uterine leiomyomas or nerve sheath tumors?", "Does the image show a structure with a spiral or concentric circular pattern?"], "relational": ["Does the image contain an area from the uterus, skin, or central nervous system with a unique organization?", "Is there a structure composed of smooth muscle, fibrous, or neural tissue displaying a distinctive pattern?", "Does the image show a larger structure like a leiomyoma, neurofibroma, or meningioma containing areas with a patterned organization?"], "contexual_behavior": ["Does the image show a pattern that becomes more pronounced during tissue remodeling with increased collagen deposition?", "Is there evidence of abnormal fiber aggregation and patterning that could be more evident in degenerative diseases?", "Is there a visible pattern that could be altered by hormonal fluctuations affecting stromal and cellular organization?"], "functions": ["Is there a region where the arrangement of cells or extracellular matrix could influence mechanical strength?", "Is there a structure that appears resilient to mechanical stress due to its organized pattern?", "Does the image show a tissue organization pattern that suggests enhanced structural support?"]}}}
[ { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "no", "extracted_concepts": [ "bicornate uterus" ], "question": "is bicornate uterus present?" }, { "answer": "cyclops", "extracted_concepts": [], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "cyclops" ], "question": "is cyclops present?" }, { "answer": "no", "extracted_concepts": [ "glissons", "tuberculoid granuloma", "liver" ], "question": "is liver with tuberculoid granuloma in glissons present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "cyclops", "extracted_concepts": [ "cyclops" ], "question": "what is present?" } ]	["tuberculoid granuloma", "cyclops", "face", "glissons", "liver", "bicornate uterus"]	{"tuberculoid granuloma": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears larger, suggesting an active immune response to a persistent infection?", "Can you identify an area that has decreased in size, possibly indicating effective immune clearance or response to treatment?", "Does the image show a region with increased fibrosis, which may be a sign of chronic inflammation or prolonged healing?", "Is there a structure with high cellularity, suggesting heightened immune cell recruitment in an early or active stage?", "Can you see an area with central necrosis, which might indicate immune failure or lesion progression?", "Does any region display altered color, potentially due to changes in vascularity, hemorrhage, or tissue necrosis?", "Is there evidence of calcification within a lesion, suggesting late-stage healing or chronicity?", "Can you identify a structure with increased lymphocyte infiltration, indicating an active cell-mediated immune response?", "Is there an area that appears less organized, possibly due to immune suppression or tissue breakdown?", "Does the image show increased collagen deposition, which may be associated with the fibrotic phase of chronic inflammation?", "Can you see a compact region where immune cells are tightly aggregated and fibrosis is present?", "Is there a structure with reduced numbers of giant cells, suggesting resolution or a decline in immune activity?", "Does any area show signs of caseation, which could indicate a shift toward a more necrotizing immune response?", "Is there evidence of increased edema, such as swelling, that might result from acute inflammation or vascular leakage?", "Can you observe changes in cellular composition within a lesion, reflecting evolution of the immune response or healing?", "Is there a region that appears softer, possibly due to early inflammation or the development of necrosis?", "Does the image show a firmer area, which may result from increased fibrosis and collagen deposition?", "Is there evidence of increased vascularization, such as new blood vessels, indicating repair or granulation tissue formation?", "Can you identify a structure with poorly defined borders, which might result from inflammation spread or tissue destruction?", "Is there a region with increased macrophage content, suggesting an active immune response to mycobacterial antigens?"], "properties": ["Is there a round or oval structure measuring between 0.5 and 2 millimeters in diameter visible in the image?", "Can you identify an area composed predominantly of epithelioid cells and lymphocytes, with occasional multinucleated giant cells?", "Does the image show a compact cluster of several hundred to a few thousand cells?", "Is there a region that appears pale pink to eosinophilic under microscopic examination?", "Can you see a firm, dense area with high cellularity and fibrous tissue?", "Is there a structure with a moderate to high collagen content, especially in a fibrous capsule?", "Does the image contain a region where necrosis is absent or minimal?", "Can you identify an area where caseation is not present?", "Is there a structure surrounded by a fibrous capsule approximately 10 to 50 micrometers thick?", "Can you see a region where lymphocytes make up about 20 to 40 percent of the cellular population?", "Is there an area where epithelioid cells constitute 40 to 70 percent of the cells?", "Does the image show a cluster where multinucleated giant cells are present in less than 10 percent of the total cell population?", "Is there a region with elevated concentrations of interferon-gamma and TNF-alpha?", "Can you identify an area with a slightly acidic pH, around 6.5 to 7.0?", "Does the image show a structure with moderate water content due to its cellular and fibrous composition?", "Is there a region where calcification is absent or minimal?", "Can you see an area with reduced oxygen concentration compared to the surrounding tissue?"], "relational": ["Does the image show a lesion located in the lung, skin, or lymph node?", "Can you identify a structure that contains epithelioid macrophages and Langhans giant cells?", "Is there an area surrounded by a rim of lymphocytes or fibroblasts?", "Does the image include a region with abundant collagen fibers encircling a central focus?", "Can you see a granulomatous structure within the pulmonary parenchyma, dermis, or peripheral lymphatic tissue?", "Is there evidence of an immune response involving T helper 1 cells or macrophages in the depicted tissue?", "Does the image show a granuloma with minimal or absent caseous necrosis?", "Can you identify a granulomatous lesion associated with lymphatic vessels or lymph nodes?", "Is there a structure formed within the parenchyma, subcutaneous tissue, or connective tissue layers?", "Does the image contain a granuloma that can be distinguished from sarcoid, foreign body, or lepromatous granulomas based on cellular composition or surrounding features?"], "contexual_behavior": ["Does the image show a structure whose ability to contain Mycobacterium infection might be compromised in the context of immune suppression or advanced disease?", "Can you identify a feature that would increase immune activity during the acute phase of infection when antigenic stimulation is high?", "Is there evidence of a structure that may lose its structural integrity in the presence of HIV infection or after immunosuppressive therapy?", "Does the image display a region where cytokine production could be decreased due to chronic disease or immune exhaustion?", "Can you see a formation that would enhance macrophage activation during early infection when Th1 cytokines are elevated?", "Is there a structure that might lose its capacity to limit bacterial spread in the context of HIV co-infection and impaired cell-mediated immunity?", "Does the image contain a feature whose function could be altered by corticosteroid therapy through suppression of inflammatory and immune responses?", "Is there evidence of impaired antigen presentation, possibly due to genetic immune deficiencies affecting MHC or T-cell function?", "Can you identify an area where fibrosis is increased as a result of prolonged inflammation and persistent immune activation?", "Does the image show a structure where T-cell recruitment might be decreased in advanced tuberculosis due to immune exhaustion or tissue remodeling?", "Is there a region that fails to resolve after antimicrobial treatment, with persistent fibrotic or calcified tissue?", "Can you see a formation that would enhance its defensive role upon reinfection by rapid activation of memory T cells?", "Is there evidence of reduced necrosis in a structure, suggesting effective immune regulation and limited tissue damage in mild disease?", "Does the image display a well-organized cellular barrier that increases containment function in localized infection?", "Is there a structure whose ability to restrict pathogen growth could be compromised in the setting of malnutrition and impaired immune cell function?"], "functions": ["Does the image show a structure that functions to contain pathogens within tissue?", "Is there evidence of localized recruitment and activation of immune cells at a site of infection?", "Can you identify a lesion that physically restricts the spread of Mycobacterium?", "Does the image display features consistent with coordinated cytokine release and immune cell interactions?", "Is there a visible barrier that limits tissue damage while controlling pathogen dissemination?", "Can you see signs of macrophage and T cell activation targeting infected cells?", "Does the image reveal an organized aggregation of lymphocytes and macrophages forming a structured lesion?", "Is there a structure that encapsulates pathogens, isolating them from surrounding healthy tissue?", "Can you identify a microenvironment where dendritic cells and macrophages interact with T cells for antigen presentation?", "Does the image suggest a lesion that maintains chronic inflammation control and immune homeostasis by preventing excessive tissue destruction?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you infer that the average age of onset for the condition in the individuals shown is between 30 and 60 years?", "Are there indications of elevated synovial fluid white blood cell counts, possibly ranging from 5,000 to 50,000 cells/\u03bcL?", "Are there radiographic features indicating mild to moderate joint erosions, with scores that might fall between 10 and 50 on the Sharp/van der Heijde scale?"], "relational": ["Are there indications of an autoimmune process targeting joint tissues?", "Is there visible damage to structures like the synovial membrane, cartilage, ligaments, or bone within a joint?", "Does the image show evidence of a condition affecting both the musculoskeletal and immune systems?"], "contexual_behavior": [], "functions": []}}, "cyclops": {"yes_questions": {"contexual_properties": ["Is there an individual in the image with an enlarged eye located at the midline of the face, suggesting abnormal optic vesicle development?", "Can you observe any unusual eye color in a single median eye that might indicate a pigmentation disorder?", "Does the image show changes in cranial size or shape that could result from midline fusion defects affecting skull growth?", "Is there evidence of altered facial structure or midline facial asymmetry consistent with incomplete separation during embryonic development?", "Can you identify abnormal composition or differentiation of ocular tissues within a single orbital cavity?", "Is there visible swelling or puffiness around the eye region that could suggest periorbital edema or inflammation?", "Does the image show a single eye that appears smaller than normal, possibly indicating microphthalmia or eye hypoplasia?", "Can you see abnormal or ectopic tissue growth in the orbital area that might be due to dysplasia or teratogenic effects?", "Is there discoloration of the skin surrounding the eye, possibly due to vascular malformation or bruising in the periorbital region?", "Does the craniofacial skeleton appear to have abnormal bone density or irregularities that could be linked to developmental defects?", "Is there increased fluid accumulation or swelling near the eye that might be caused by lymphatic malformation or cyst formation?", "Can you observe abnormal pigmentation of the eye, such as irregular melanin distribution or color changes?", "Are there structural abnormalities of the eyelid that could be related to disrupted morphogenesis or craniofacial defects?", "Is there any evidence of abnormal growths or masses in the craniofacial region that might indicate dysplasia or neoplastic proliferation?", "Does the skin over the forehead show changes in texture, such as thickening or scarring, that could be associated with cutaneous anomalies?"], "properties": ["Is there a figure in the image whose stature greatly exceeds that of an average human?", "Can you identify an individual whose estimated weight would be several hundred kilograms based on their massive build?", "Does the image show a being with pale, grayish, or ruddy skin coloration?", "Is there a character with a single, round eye centrally located on the forehead?", "Can you find a monocular figure present in the scene?", "Does the image include an entity whose height appears to be between 4 and 6 meters?", "Is there a figure whose apparent muscle mass suggests extremely high strength?", "Can you see an individual whose bone structure would require greater density to support their size?", "Is there a being whose body temperature is likely similar to that of mammals?", "Does the image show a character with dark or black hair?", "Can you identify a figure whose head circumference is much larger than that of a human?", "Is there an entity whose blood volume would be significantly greater than that of a human, proportional to their size?", "Does the image depict a being with thick and tough skin, possibly providing extra protection?", "Can you see a figure whose apparent strength would far surpass human capabilities?"], "relational": ["Does the image show a congenital anomaly affecting both the craniofacial and nervous systems?", "Is there evidence of abnormal development in the orbits, nose, or forebrain?", "Can you identify any structural changes in the midline face, frontal region, or nasal region?", "Is there a visible fusion of the orbits or absence of nasal structures?", "Does the image display a single median eye or fused orbital regions?", "Is there an absence of nasal features in the midline facial area?", "Can you see signs of severe malformation of the forebrain, such as those seen in holoprosencephaly?", "Is there an abnormality involving embryonic regions like the prosencephalon or frontonasal prominence?", "Does the image suggest disruption of midline patterning pathways, such as those involving the Sonic Hedgehog pathway?", "Are there visible changes in the central nervous system or pituitary gland associated with craniofacial anomalies?"], "contexual_behavior": ["Does the image show evidence of increased activity in a signaling pathway during early embryonic stages such as gastrulation or mesendoderm formation?", "Is there a structure present that could be affected by mutations in the ndr2 gene during embryonic development?", "Can you identify any features that might indicate decreased expression of a developmental regulator in response to heat shock or chemical exposure?", "Does the image suggest a failure to establish left-right asymmetry during somitogenesis, possibly due to disrupted signaling?", "Are there visible changes in midline or endodermal structures that could result from dynamic signaling during organogenesis?", "Is there evidence of altered neural or craniofacial development that might be associated with exposure to teratogenic substances like cyclopamine?", "Can you see any signs of reduced activity in embryonic signaling pathways under hypoxic conditions?", "Does the image reveal abnormal optic vesicle or eye development that could be linked to pathway disruption during early embryogenesis?", "Are there indications of increased signaling activity during tissue regeneration, particularly in regions undergoing mesendodermal cell specification?", "Is there evidence of functional decline in embryonic signaling components that could be attributed to oxidative stress?", "Can you identify features suggestive of overactive Nodal signaling, as might be seen in certain developmental disorders?", "Does the image reflect changes in expression levels of a developmental regulator, with peak activity during gastrulation and reduced levels at later stages?", "Are there signs of impaired cell differentiation that could result from disruption of the Nodal pathway under pathological conditions?", "Is there evidence of increased signaling activity in response to injury and tissue regeneration?", "Can you observe abnormal morphogenesis that might result from genetic or environmental perturbations disrupting a key signaling pathway?"], "functions": ["Does the image show evidence of a process that regulates embryonic development or cellular signaling?", "Can you identify features indicative of Nodal signaling activity essential for mesoderm or endoderm formation?", "Is there visual evidence of axis formation or germ layer specification occurring in the specimen?", "Does the image suggest modulation of gene expression in response to Nodal signaling during early development?", "Can you observe signs of tissue differentiation, particularly the specification of mesodermal or endodermal cell types?", "Is there evidence of organogenesis, such as the development of the notochord or heart, in the image?", "Does the image show processes related to cell fate specification or lineage commitment of progenitor cells?", "Can you see patterns or boundaries that suggest developmental patterning and proper tissue organization?", "Is there visual indication of coordinated cell movement or differentiation processes involved in morphogenesis?", "Does the image provide clues of interactions between signaling molecules, such as Lefty or Squint, that modulate developmental pathways?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image contain a device located within the uterine cavity?", "Is there a visible object that could serve as a contraceptive by being placed inside the uterus?", "Does the image show a foreign object whose presence suggests a method of birth control?"], "relational": ["Is there evidence of an object that has been inserted through the cervix and now resides superior to it?", "Does the image show a foreign object adjacent to the fallopian tubes or ovaries?", "Is there a structure within the uterus that is not a native anatomical part?"], "contexual_behavior": ["Is there evidence of a device that could become less effective if it is partially or completely expelled from the uterus?", "Is there a device present that could lose its ability to prevent implantation if it is not fully within the uterine cavity?", "Does the image show a structure whose function may be impaired in the presence of uterine anomalies such as a septate or bicornuate uterus?"], "functions": ["Does the image show a device that serves to prevent pregnancy by interfering with fertilization or implantation?", "Is there a structure present that could induce local inflammation or modify the uterine lining?", "Is there a device present that could thicken cervical mucus and block sperm penetration?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": ["Do you notice abnormal fat deposits within the organ, suggesting fatty change or steatosis?", "Does the image show an organ that appears shrunken, suggesting advanced chronic damage?", "Can you see signs of increased fibrous tissue within an organ, consistent with chronic inflammation and collagen deposition?"], "properties": ["Does the image suggest elevated bilirubin or ammonia levels through associated tissue changes?", "Does the image show an organ with coarse, irregular, and large nodularity on its surface?", "Is there evidence of extensive fibrosis or diffuse fibrous tissue replacing normal parenchyma?"], "relational": ["Is there visible replacement of normal parenchyma by fibrous tissue or regenerative nodules?", "Does the image show evidence of altered hepatic lobules or portal tracts?", "Does the image display changes in the periportal or centrilobular regions?"], "contexual_behavior": ["Can you see signs of blood volume dysregulation, such as features consistent with hypoalbuminemia or vascular homeostasis disruption?", "Does the image suggest hyperbilirubinemia or jaundice, indicating bilirubin clearance failure?", "Can you identify signs of portal hypertension or malnutrition resulting from nutrient processing deficit?"], "functions": ["Can you identify features that suggest accumulation of toxins, like ammonia, which might indicate impaired detoxification or hepatic encephalopathy?", "Can you observe indications of hormonal imbalance or altered steroid metabolism, possibly reflecting endocrine dysfunction?", "Is there visual evidence of reduced bile production, such as signs of jaundice or cholestasis?"]}}, "glissons": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears enlarged in the context of hepatic inflammation or portal hypertension?", "Is there a visible feature that changes color in association with jaundice or congestive hepatopathy?", "Can you identify a structure that looks swollen, possibly due to liver edema or acute hepatitis?", "Does the image contain a region with increased thickness, as seen in chronic liver diseases like fibrosis or cirrhosis?", "Is there evidence of fibrotic tissue in an area affected by progressive liver fibrosis or cirrhosis?", "Can you observe abnormal tissue composition, such as infiltration by inflammatory or fibrous cells, in the setting of advanced liver disease?", "Does the image reveal an edematous appearance in a structure during acute liver injury or congestive states?", "Are there nodules present that could be associated with nodular regenerative hyperplasia or cirrhosis?", "Is there a region that appears reduced in size, possibly indicating atrophic liver conditions or advanced cirrhosis?", "Can you detect a change in texture, such as increased firmness or irregularity, due to fibrosis, edema, or chronic inflammation?", "Does the image show evidence of fat accumulation in a structure, as might occur in severe hepatic steatosis?", "Is there increased cellularity visible, suggesting active inflammation or immune cell infiltration?", "Can you identify an area that appears hardened, potentially due to advanced fibrosis or cirrhosis?", "Does the image show loss of structural integrity in a region affected by severe liver injury or necrosis?", "Are there signs of inflammation, such as redness or swelling, in association with hepatitis or other inflammatory liver conditions?", "Can you observe calcifications that might indicate chronic granulomatous disease or healed infections?", "Is there a structure that appears pale, possibly due to anemia, ischemia, or severe fatty liver?", "Does the image reveal increased vascularization, as might be seen with chronic inflammation or neovascularization in liver disease?", "Is there evidence of increased connective tissue in a region affected by chronic liver fibrosis or cirrhosis?", "Can you identify an atrophic appearance in a structure, as seen in end-stage liver disease or chronic atrophy?"], "properties": ["Does the image show a thin, continuous, and smooth membrane enveloping another structure?", "Can you identify a pale or whitish layer that appears to be about 0.5 to 1 millimeter thick?", "Is there a structure present that has a firm yet flexible texture, suggestive of connective tissue?", "Does the image contain a membrane composed of dense irregular connective tissue with visible collagen and elastic fibers?", "Can you see a layer that might contain fibroblasts, endothelial cells, or occasional immune cells?", "Is there evidence of a structure with high collagen content, providing tensile strength to a surrounding membrane?", "Does the image show a membrane with moderate elastic fiber content, allowing for some elasticity?", "Can you identify a layer with moderate water content, typical of connective tissue?", "Is there a membrane whose density appears similar to other dense connective tissues, around 1.04 to 1.06 g/cm\u00b3?", "Does the image suggest the presence of a structure with moderate vascularization, containing small blood vessels and lymphatics?"], "relational": ["Does the image show a structure that is part of the hepatic system?", "Can you identify a component that is connected to the portal vein, hepatic artery, or bile ducts?", "Is there a region containing connective tissue, vascular tissue, or biliary epithelium?", "Does the image contain a structure that is part of the liver?", "Can you see an area associated with vessels such as the portal vein, hepatic artery, or lymphatic vessels?", "Is there a connective tissue sheath surrounding a portal triad within the liver?", "Does the image show ducts or channels such as bile ducts or lymphatic channels within the liver?", "Can you identify a structure located in the hepatic region of the abdominal cavity?", "Is there a component surrounded by liver parenchyma and hepatic lobules?", "Does the image contain a structure composed of connective tissue, blood vessels, bile ducts, and lymphatics?"], "contexual_behavior": ["Is there evidence of disrupted architecture in the connective tissue surrounding the portal tracts, suggesting progressive extracellular matrix deposition?", "Can you identify signs of impaired bile transport within the portal areas, such as obstruction or inflammation affecting intrahepatic bile ducts?", "Does the image show compression of portal vessels that could indicate reduced support for hepatic blood flow due to fibrotic expansion?", "Are there features consistent with extensive scarring replacing normal connective tissue in the portal regions, as seen in cirrhosis?", "Can you observe fibrous thickening within the portal tracts that might increase resistance to portal blood flow, as occurs in portal hypertension?", "Is there visible damage to the ductal epithelium of bile ducts within the portal areas, possibly due to immune-mediated injury in inflammatory states?", "Does the image suggest activation of immune cells within the portal tracts, which could indicate altered immune responses during hepatic infection?", "Are there signs of decreased elasticity in the connective tissue of the portal regions, such as increased stiffness from collagen accumulation in chronic liver disease?", "Can you detect excess matrix protein deposition by fibroblasts or stellate cells in the portal areas, suggesting enhanced fibrogenesis during hepatic injury?", "Is there evidence of disrupted microvascular flow within the portal tracts that could impair nutrient exchange in advanced liver pathology?"], "functions": ["Does the image show a connective tissue sheath surrounding an organ involved in digestion?", "Can you identify a structure that provides structural support and protection to hepatic tissue?", "Is there a visible layer that encapsulates the liver and allows blood vessels, lymphatics, and nerves to enter the organ?", "Does the image include a feature responsible for maintaining the integrity of the liver's external surface?", "Can you see a structure that mediates interactions between the liver and surrounding tissues?", "Is there evidence of a layer that accommodates the expansion and contraction of the liver during physiological changes such as respiration or blood flow?"]}, "no_questions": {"contexual_properties": ["Is there abnormal vascularization present, indicating angiogenesis associated with tumor progression?", "Are there visible mitotic figures or signs of high proliferative activity within a tumor?", "Does the image show increased stromal content or signs of a desmoplastic reaction in the tumor microenvironment?"], "properties": ["Is there positivity for basal cytokeratins, such as CK5/6 or CK14, in the tumor cells?", "Can you see features consistent with a high proliferation index, such as increased Ki-67 staining?", "Does the tumor exhibit a high mitotic count, indicating increased cell division?"], "relational": ["Does the image contain breast lobules or ducts with abnormal cellular features?", "Does the specimen appear to be from a core needle biopsy or surgical excision of breast tissue?", "Can you identify lymphatic vessels or lymph nodes that might be involved in tumor spread?"], "contexual_behavior": [], "functions": ["Is there visual evidence that could be associated with a high recurrence rate or early recurrence of the tumor?", "Can you identify evidence of genomic instability within the depicted tumor tissue?", "Is there a structure present that appears to grow independently of hormonal signals?"]}}, "liver": {"yes_questions": {"contexual_properties": ["Is there an organ in the image that appears enlarged, which could indicate inflammation, congestion, or fatty infiltration?", "Can you identify a structure that shows signs of excess fat accumulation, possibly due to metabolic syndrome or alcohol use?", "Does any organ in the image display a yellowish, dark, or greenish hue, suggesting underlying pathological changes?", "Is there a structure that appears heavier or denser, potentially due to fat, iron, or tumor infiltration?", "Can you see an organ that looks shrunken or atrophic, which might be associated with advanced cirrhosis or chronic disease?", "Is there evidence of iron accumulation, such as increased density or discoloration, that could indicate iron overload disorders?", "Do you observe any signs of fibrosis or scarring, such as increased firmness or irregular texture, in an organ that could be affected by chronic injury?", "Is there a structure with a nodular or irregular surface, possibly reflecting cirrhosis or regenerative changes?", "Can you identify an organ with abnormal texture, such as increased firmness, nodularity, or softening, which may result from fibrosis, fat, or tumor infiltration?", "Is there evidence of abnormal tissue growth, such as masses or lesions, that could represent tumors, metastases, or regenerative nodules?", "Does any structure appear swollen or edematous, which might be due to acute inflammation or congestion?", "Can you see an organ that appears hypodense or hyperdense on imaging, suggesting fat accumulation, iron overload, or tumor presence?", "Is there a visible yellow coloration in an organ, possibly indicating fat infiltration or severe jaundice?", "Do you observe increased fat content in a structure, which could be related to obesity, metabolic syndrome, or excessive alcohol intake?", "Is there an organ with increased volume, possibly due to inflammation, congestion, or tumor growth?", "Can you identify unusual surface features, such as nodularity or irregularity, that might be seen in chronic hepatitis or metastatic disease?", "Is there evidence of cellular changes, such as atypia or regeneration, within an organ that could indicate inflammation or neoplastic transformation?"], "properties": ["Does the image show an organ with a wedge-shaped or triangular appearance?", "Can you identify a structure that is reddish-brown in color?", "Is there an object whose size appears to be approximately 15 to 17 centimeters along the midclavicular line?", "Does the image contain a structure that could weigh between 1.4 and 1.6 kilograms in an adult?", "Can you see an organ with a soft and smooth texture?", "Is there a structure with a volume likely between 1200 and 1600 milliliters?", "Does the image show a tissue that might be composed of hepatocytes, Kupffer cells, stellate cells, or sinusoidal endothelial cells?", "Can you identify an object where the fat content is likely less than 5% of its weight?", "Is there a structure that could contain iron levels of about 0.5 to 1.5 milligrams per gram of dry tissue?", "Does the image show a tissue that might contain enzymes such as ALT, AST, ALP, or cytochrome P450?", "Can you see a structure that produces proteins like albumin, clotting factors, or transferrin?", "Is there an object where glycogen storage might account for about 1\u20132% of its weight?", "Does the image show a structure that could have an oxygen level of 30\u201340 mmHg in its portal vein?", "Can you identify a tissue with a pH close to 7.0 to 7.4?", "Is there an organ whose temperature is likely around 37 degrees Celsius?", "Does the image show a structure with a water content of about 70\u201375% by weight?", "Can you see a tissue where cholesterol levels might be approximately 2\u20135 milligrams per gram?", "Is there an object with a density close to 1.05 grams per cubic centimeter?", "Does the image show a structure that is divided into four anatomical lobes?"], "relational": ["Does the image show an organ that is part of the digestive system and located in the right upper quadrant of the abdominal cavity?", "Can you identify a structure that is positioned near the stomach, gallbladder, or right kidney?", "Is there a visible organ connected to blood vessels such as the hepatic artery, portal vein, or hepatic veins?", "Does the image include ducts like the common hepatic duct or bile ducts associated with a major abdominal organ?", "Can you see a structure composed of distinct regions such as a right lobe, left lobe, caudate lobe, or quadrate lobe?", "Is there evidence of specialized cells such as hepatocytes, Kupffer cells, or hepatic stellate cells within any structure?", "Does the image contain an organ that interacts with the pancreas, small intestine, or gallbladder in the process of digestion?", "Can you identify a structure that is connected to the gallbladder via the biliary tract, with the gallbladder serving as a storage site for bile?", "Are there supporting anatomical features such as the falciform ligament, coronary ligament, or round ligament visible in association with a large abdominal organ?"], "contexual_behavior": ["Does the image show a structure whose detoxification activity might be reduced in cases of hepatic failure?", "Is there an organ present that could fail to regulate blood sugar in diabetes mellitus?", "Can you identify a structure that would produce fewer clotting factors during cirrhosis?", "Does the image contain something that might slow down bile production in the presence of biliary obstruction?", "Is there an object that could increase fat metabolism during prolonged fasting?", "Can you see a structure that would stop converting ammonia into urea effectively during hepatic encephalopathy?", "Is there an organ that might reduce protein synthesis in severe hepatitis?", "Does the image show a structure whose function could decline due to chronic alcohol abuse?", "Is there an object that would increase enzyme activity during inflammation such as hepatitis?", "Can you identify a structure that might slow cholesterol regulation in metabolic syndrome?", "Does the image contain something that could struggle to store glucose as glycogen during insulin resistance?", "Is there an organ that would show impaired hormone breakdown in severe hepatic impairment?", "Can you see a structure that increases its metabolic workload during infection or trauma?", "Is there an object that might fail to filter toxins efficiently in hepatic insufficiency?", "Does the image show a structure whose function may improve after fasting due to reduced metabolic load?", "Is there an organ that could have reduced regeneration capacity in chronic disease or aging?", "Can you identify a structure that alters its behavior by increasing immune response during viral infection?", "Does the image contain something that stops responding to insulin properly in type 2 diabetes?", "Is there an object that increases bile secretion after a fatty meal due to cholecystokinin stimulation?", "Can you see a structure that decreases its contribution to immune defense during immunosuppression?"], "functions": ["Is there a structure in the image responsible for detoxifying the bloodstream by enzymatically breaking down toxins?", "Can you identify an organ that produces a digestive fluid necessary for emulsifying and absorbing dietary fats?", "Does the image show a structure that stores nutrients such as glycogen, vitamins, or minerals for later release?", "Is there an object involved in maintaining blood sugar levels by converting glucose to glycogen and releasing it when needed?", "Can you see a structure that processes carbohydrates, fats, and proteins to regulate energy balance?", "Is there an organ in the image that synthesizes most plasma proteins, including albumin and clotting factors?", "Does the image contain a structure that metabolizes and inactivates hormones to regulate their levels?", "Can you identify an object that filters blood by removing toxins, old cells, and metabolic waste products?", "Is there a structure that metabolizes drugs by converting them into forms suitable for excretion?", "Does the image show an organ that produces blood clotting factors necessary for normal coagulation?", "Can you see a structure that converts toxic ammonia into urea for safe excretion by the kidneys?", "Is there an object that performs immune functions by housing cells capable of phagocytosing pathogens?"]}, "no_questions": {"contexual_properties": ["Is there evidence of hormonal changes, such as elevated cortisol or adrenaline, that could accelerate the breakdown of stored fats?", "Is there visual evidence of insulin deficiency or resistance, which could lead to increased mobilization of stored fats?", "Are there features consistent with metabolic syndrome or diabetes, where blood lipid composition may be altered due to changes in fat metabolism?"], "properties": ["Does the image suggest that an initial metabolic reaction occurs in the cytosol, followed by subsequent steps in the mitochondria?", "Can you see evidence of glycerol concentrations in plasma within the range of 0.05\u20130.1 mmol/L?", "Can you identify a reaction that requires one molecule of water per hydrolysis step?"], "relational": ["Does the image show any part of the digestive system involved in the processing of dietary fats?", "Does the image show the small intestine in a way that suggests active enzymatic digestion and absorption of lipids?", "Is there a region of the digestive tract, such as the duodenum or jejunum, that is specialized for lipid processing?"], "contexual_behavior": ["Does the image reveal rapid fat loss that could be consistent with cachexia and increased catabolic signaling?", "Is there evidence of suppressed fat breakdown that might be associated with chronic hyperinsulinemia in obesity?", "Can you identify features suggestive of impaired fat metabolism as seen in obesity or type 2 diabetes?"], "functions": ["Does the image show evidence of a process that converts stored fats into energy?", "Can you see signs of triglyceride hydrolysis resulting in free fatty acids and glycerol?", "Does the image indicate the formation of acetyl-CoA for ketone body production in the liver?"]}}, "bicornate uterus": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify an organ that is adjacent to the bladder or rectum?", "Is there a structure located near the ovaries?", "Does the image contain an organ with two distinct horns?", "Can you see a structure that has either a single cervix or partially separated cervices?", "Is there an object whose walls appear to be composed of layers such as endometrium, myometrium, and perimetrium?", "Does the image show a structure that receives blood supply from uterine or ovarian arteries?", "Can you identify an organ supported by ligaments like the broad ligament, round ligament, or uterosacral ligament?", "Is there a structure connected to the cervix, which opens into the vaginal canal?", "Can you see an organ that is joined to the fallopian tubes at the apex of two separate regions?", "Does the image show a structure located near the sigmoid colon in the pelvic cavity?", "Is there an organ present that has two separate internal cavities?", "Can you identify a structure with a prominent external indentation at its uppermost part?"], "contexual_behavior": [], "functions": ["Does the image show a reproductive organ with two separate internal cavities where embryo implantation could occur?", "Can you identify a structure that participates in menstruation by shedding the endometrial lining from both of its horns?", "Is there an organ present that provides a divided intrauterine space capable of supporting one or more fetuses during pregnancy?", "Does the image contain a structure where sperm migration could occur through two distinct horns toward the fallopian tubes for fertilization?", "Can you see an organ that supports gestation by providing a nurturing environment for embryo implantation and fetal growth, but with a divided cavity that may affect gestational capacity?", "Is there a structure that contracts during labor to expel the fetus, where its abnormal shape could increase the risk of malpresentation or preterm birth?", "Does the image include an organ that responds to hormonal changes by thickening and shedding the endometrial lining in both horns during the menstrual cycle?", "Can you identify a structure where endometrial shedding involves the loss of lining from two separate uterine cavities during menstruation?", "Is there an organ that regulates the uterine environment for conception by maintaining endometrial receptivity in both horns, with a divided structure that may influence implantation success?"]}, "no_questions": {"contexual_properties": ["Does the image contain any tissue patterns that resemble a vortex or whirlpool shape?", "Is there a region in the image where elements are organized in a concentric or whorled manner?", "Does the image display any structures with a spiral or circular pattern?"], "properties": ["Is there a visible pattern formed by bundles of collagen fibers and spindle-shaped cells?", "Do you observe cells arranged in concentric or spiral layers within any structure?", "Does the image show a structure with a spiral or concentric circular pattern?"], "relational": ["Is there a structure composed of smooth muscle, fibrous, or neural tissue displaying a distinctive pattern?", "Is there a mass or lesion resembling a fibroid, schwannoma, or meningioma present?", "Can you identify a region with concentric layers within the tissue?"], "contexual_behavior": ["Can you identify an area where the organization of collagen fibers suggests ongoing fibrosis?", "Can you see a pattern that could result from abnormal cell proliferation?", "Is there a disruption of normal tissue patterns that might be explained by chronic inflammation and matrix remodeling?"], "functions": ["Is there a structure that appears resilient to mechanical stress due to its organized pattern?", "Can you identify a region where morphogenesis, fibrosis, or neoplastic transformation might be suggested by the tissue pattern?", "Can you see evidence of patterned growth that could reflect either normal development or a pathological process?"]}}}
[ { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "no", "extracted_concepts": [ "lymphangiomatosis" ], "question": "is lymphangiomatosis present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bilateral cleft palate" ], "question": "is bilateral cleft palate present?" }, { "answer": "no", "extracted_concepts": [ "abruption" ], "question": "is abruption present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" } ]	["bilateral cleft palate", "abruption", "lymphangiomatosis", "face"]	{"bilateral cleft palate": {"yes_questions": {"contexual_properties": ["Does the image show a palatal gap that appears wider than usual, possibly indicating a pre-surgical or growing state?", "Can you observe a deepened separation in the palate that might result from vertical growth of the maxilla during childhood?", "Is there evidence of significant tissue deficiency in the palatal region, suggesting a preoperative or delayed repair condition?", "Do you see abnormal tissue characteristics, such as irregular surfaces, that could be associated with chronic inflammation or infection?", "Is there a palatal defect that appears more pronounced, possibly reflecting a period of rapid craniofacial growth without surgical intervention?", "Can you identify areas of redness or purplish discoloration in the palate, which may indicate infection or inflammation?", "Is there visible scar tissue in the palatal region, suggesting previous surgical repair?", "Do you notice swelling in the palate that could be due to recent surgery or acute infection?", "Is the palatal gap visibly reduced, possibly indicating a successful surgical intervention?", "Can you detect the presence of fluid or exudate in the palatal area, which might be due to infection, inflammation, or fistula formation?", "Are there any ulcerations or open sores in the palate that could result from trauma, infection, or poor oral hygiene?", "Do you see abnormal mucosal texture, such as roughness or irregularity, possibly due to repeated infections, scarring, or failed repairs?", "Is the palatal separation less apparent, potentially reflecting tissue remodeling after surgical repair and aging?", "Can you observe signs of bleeding in the palatal region, which may occur during surgery, trauma, or acute infection?", "Is there a visible fistula or abnormal opening in the palate, possibly indicating a postoperative complication or incomplete healing?"], "properties": ["Is there a structure in the image that shows a gap measuring between 5 and 20 millimeters in width?", "Can you identify a separation extending from the incisive foramen to the uvula, with a length of approximately 20 to 40 millimeters?", "Does the image display a shallow to moderate depression, with a depth between 2 and 8 millimeters, in the palatal region?", "Is there a visible V-shaped or U-shaped gap along the midline of the palate?", "Can you see a midline defect affecting both the hard and soft palate symmetrically?", "Does the image show a structure with a frequency of occurrence in live births between 0.02 and 0.05 percent?", "Is there tissue present that appears pink to reddish, possibly with areas of erythema, in the palatal region?", "Can you identify disrupted mucosa, connective tissue, or exposed bone or cartilage within a palatal gap?", "Does the image reveal a complete separation between the palatal shelves, with no fusion at the midline?", "Is there an area where the palatal tissue thickness is reduced to less than 2 millimeters?", "Can you observe an irregular or uneven surface texture, possibly with ulcerations or granulation tissue, in the palate?", "Is there evidence of bony defects in the palatal region, given that such defects are present in more than 90 percent of similar cases?", "Does the image show involvement of both the hard and soft palate, with the hard palate nearly always affected and the soft palate in most cases?", "Can you see discontinuity or compromised integrity of the mucosa, with exposure of underlying structures in the palate?", "Is the distance between two cleft margins in the palatal region within the range of 5 to 20 millimeters?"], "relational": ["Does the image show a disruption involving both the hard and soft regions forming the roof of the oral cavity?", "Can you identify a gap or separation affecting the midline and lateral aspects of the palatal shelves?", "Is there evidence of interrupted continuity in the maxilla or palatine bones within the oral cavity?", "Does the image reveal separation of the mucosal, muscular, and bony layers of the palate?", "Can you observe a defect indicating failure of fusion between the palatal processes of the maxilla?", "Is there a visible abnormality that could impact muscles such as the levator veli palatini or tensor veli palatini?", "Does the image show a structure adjacent to the nasal septum, upper lip, or lateral nasal wall that appears disrupted?", "Are the anatomical boundaries from the alveolar ridge to the uvula and lateral palatal shelves visibly altered?", "Can you detect additional anomalies such as a cleft in the upper lip, irregular dental development, or nasal deformities?", "Is there an abnormal opening between the oral and nasal cavities that could affect speech or feeding?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structural defect that could allow food or liquids to pass from the mouth into the nasal cavity, potentially leading to nasal regurgitation?", "Is there a visible abnormal communication between the oral and nasal spaces that might disrupt normal swallowing or oropharyngeal coordination?", "Can you identify a feature that could prevent proper closure of the velopharyngeal port, possibly resulting in hypernasal speech or articulation difficulties?", "Does the image suggest a condition that would make it difficult for an infant to create suction during feeding, potentially leading to poor intake or prolonged feeding times?", "Is there a structural abnormality that could compromise airway protection during eating or drinking, increasing the risk of aspiration or choking?", "Can you see an oronasal fistula or palatal defect that disrupts the normal separation between the oral and nasal cavities?", "Does the image show a feature that might alter nasal airflow or increase the likelihood of airway obstruction, possibly causing breathing difficulties?", "Is there evidence of a defect that could reduce the ability to generate intraoral pressure, affecting effective sucking, swallowing, or speech sound production?", "Can you identify a structural issue that might impair Eustachian tube function, increasing the risk of recurrent ear infections or middle ear effusion?", "Does the image suggest disturbances in facial growth or dental alignment, such as maxillary deficiency or malocclusion?", "Is there any indication that the individual may have developed compensatory mechanisms, such as atypical speech articulation or altered swallowing patterns, to adapt to a structural defect in the palate?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify any changes in the overlying skin that may be related to underlying pathology?", "Are there signs of disease affecting the bones, lungs, liver, or brain that could suggest metastatic spread?", "Is there evidence of disease extending to the skin, pectoral fascia, or the lateral or medial borders of the breast?"], "contexual_behavior": [], "functions": ["Does the image suggest the presence of cells that may evade immune detection or suppress immune responses?", "Can you identify an area with evidence of uncontrolled cell proliferation or abnormal growth patterns?", "Is there a region where immune cells are recruited or inflammation is present in association with abnormal tissue?"]}}, "abruption": {"yes_questions": {"contexual_properties": ["Does the image show evidence of significant separation between the placenta and the uterine wall, possibly leading to hemorrhage?", "Can you identify any changes in the size of the placenta that might suggest extensive detachment or hematoma formation?", "Is there visible discoloration, such as dark or bluish areas, behind the placenta that could indicate retroplacental hemorrhage?", "Does the image reveal any clots located between the placenta and the uterine wall?", "Can you observe thickening or enlargement of the uterine wall that might result from blood infiltrating the myometrium?", "Is there any indication of decreased oxygen supply to the fetus, such as signs of placental insufficiency or fetal hypoxia?", "Does the image suggest accumulation of blood within the uterus without evidence of external expulsion?", "Can you see any changes in amniotic fluid volume that could be associated with fetal distress or oligohydramnios?", "Is there visible damage to placental tissue, such as infarcts, hemorrhages, or disrupted areas?", "Does the image suggest increased uterine tenderness, possibly due to myometrial irritation?", "Can you identify abnormal placental texture, such as areas altered by clot formation or tissue necrosis?", "Is there visual evidence that could correspond to significant maternal blood loss, such as anemia or hypovolemia?", "Does the image indicate a drop in maternal blood pressure, possibly due to acute blood loss?", "Can you observe increased uterine tone or firmness, potentially resulting from blood accumulation and muscle contraction?", "Is there expelled blood that appears dark or clotted, suggesting partial retention and breakdown before expulsion?"], "properties": ["Is there an area adjacent to the placenta that appears hypoechoic or has a heterogeneous appearance on imaging?", "Can you identify a region between the placenta and uterine wall that shows increased thickness compared to the surrounding placental tissue?", "Does the image reveal a lesion with an irregular or crescentic shape along the placental margin?", "Is there evidence of a coarse or uneven texture in a region near the maternal side of the placenta?", "Can you see a dark red or maroon area suggestive of accumulated blood near the placenta?", "Does the image show a region with low or mixed echogenicity relative to the placenta?", "Is there a visible area that appears firm or rubbery in consistency, possibly due to a blood clot?", "Can you estimate if a portion of the placental surface, ranging from less than 10% to over 50%, is separated from the uterine wall?", "Does the image suggest a partial or complete separation of the placenta from the uterine wall?", "Is there a region whose size varies from a few centimeters to covering a significant portion of the placenta?", "Can you identify a lesion whose thickness measures several millimeters to centimeters?", "Does the image suggest the presence of a blood clot weighing from a few grams up to several hundred grams?", "Is there visual evidence of acute changes near the placenta that could have developed over minutes to hours?"], "relational": ["Does the image show any abnormality involving the placenta and the uterine wall?", "Can you identify a region where placental tissue appears separated from the decidua basalis?", "Is there evidence of premature detachment of the placenta from the uterus?", "Does the image reveal disruption at the placental implantation site on the uterine wall?", "Are there visible changes in maternal structures such as the myometrium or uterine blood vessels near the placenta?", "Can you observe any impact on fetal structures like the chorionic villi or umbilical cord?", "Is there any indication of disrupted spiral arteries or intervillous vessels in the placental region?", "Does the image show alterations in the anatomical connection between the placenta and the uterine wall?", "Are there any abnormalities involving the amniotic membrane or chorion adjacent to the placenta?"], "contexual_behavior": ["Does the image show evidence of a structure that has separated from the uterine wall before delivery, potentially impairing oxygen and nutrient transfer to the fetus?", "Is there visual indication of decreased fetal blood supply that could be associated with maternal trauma and placental detachment?", "Can you identify signs of increased maternal blood loss during labor that might result from separation of a structure responsible for fetal support?", "Does the image suggest abnormal uterine contraction patterns that could be triggered by detachment of a key maternal-fetal interface?", "Is there evidence of reduced removal of fetal metabolic byproducts, possibly due to impaired exchange at the maternal-fetal boundary?", "Can you observe features indicating altered maternal blood coagulation, such as signs of coagulopathy following injury to a structure involved in maternal-fetal exchange?", "Does the image suggest disruption of hormonal signaling between mother and fetus, potentially due to separation of an endocrine-active interface?", "Is there any indication of preterm delivery or early labor that could be linked to dysfunction of a structure responsible for placental support?", "Can you detect decreased fetal heart rate variability or signs of fetal distress that might result from reduced perfusion at the maternal-fetal interface?", "Does the image show signs of impaired maternal cardiovascular stability, such as hypovolemia or shock, that could be associated with significant blood loss from a detached structure?", "Is there visual evidence of decreased hormone production or endocrine dysfunction at the maternal-fetal interface due to structural separation?", "Can you identify features suggesting compromised fetal growth or restricted development, possibly resulting from chronic insufficiency of a structure responsible for nutrient and oxygen delivery?", "Does the image indicate altered maternal immune response at the maternal-fetal interface, such as immune activation following injury to a key barrier?", "Is there evidence of impaired gas exchange between mother and fetus, such as reduced surface area for oxygen and carbon dioxide transfer, due to separation of a critical interface?", "Can you observe loss of barrier function against toxins at the maternal-fetal interface, potentially increasing fetal exposure due to detachment of a protective structure?"], "functions": ["Does the image show evidence of placental separation that could lead to fetal distress or maternal hemorrhage?", "Can you identify signs of reduced placental blood flow, such as detachment or vascular disruption?", "Is there visual indication of impaired maternal-fetal circulation that might result in fetal hypoxia or nutrient deficiency?", "Does the image suggest a compromised placental interface that could limit gas exchange or reduce nutrient transfer?", "Are there features consistent with uterine contractions possibly triggered by prostaglandin release or myometrial irritation?", "Can you observe signs of ruptured maternal vessels or retroplacental hemorrhage that may contribute to maternal blood loss?", "Is there evidence of conditions that could increase the risk of preterm birth or perinatal mortality due to fetal hypoxia?", "Does the image suggest activation of the coagulation cascade or features that could indicate an increased risk of thrombosis?", "Are there visual cues of physiological responses such as uterine tenderness or signs suggestive of shock?", "Can you see alterations in placental structure that might disrupt hormone production or impair waste removal?"]}, "no_questions": {"contexual_properties": ["Can you identify areas where there is excessive fluid accumulation within the villous stroma, indicating hydropic change?", "Can you identify areas with increased cellular covering, consistent with excessive trophoblastic proliferation in complete moles?", "Do any structures appear more fragile or have thinned walls, possibly due to marked edema?"], "properties": ["Do any objects display a thin or attenuated outer layer?", "Is there evidence of marked edema or significant fluid accumulation within certain structures?", "Can you see features with an increased surface area relative to normal villi due to swelling?"], "relational": ["Can you identify tissue that is part of the villous or chorionic region of the placenta?", "Can you identify areas where maternal blood in the intervillous space interacts with fetal vessels within villi?", "Does the image include villi that differ from normal chorionic villi or avascular villi?"], "contexual_behavior": [], "functions": ["Can you identify areas where nutrient and gas exchange between mother and fetus might be impaired due to edematous tissue?", "Does the image show placental structures that appear abnormal and do not perform typical functions during pregnancy?", "Can you see signs that might indicate altered hormone production or abnormal trophoblastic activity in the placenta?"]}}, "lymphangiomatosis": {"yes_questions": {"contexual_properties": ["Does the image show any abnormal proliferation of lymphatic vessels?", "Can you identify regions with diffuse or multifocal lymphatic channel involvement?", "Is there evidence of a condition affecting multiple organs or tissues through lymphatic vessel overgrowth?", "Does the image reveal any widespread lymphatic abnormalities that could indicate a systemic disorder?"], "properties": ["Does the image show multiple masses that are diffuse throughout the tissue?", "Can you identify lesions that range in size from a few millimeters to several centimeters?", "Are there structures that appear translucent, pale, or yellowish in color?", "Is there evidence of tissue composed predominantly of lymphatic vessels and connective tissue?", "Do any of the visible lesions seem to contain fluid volumes in the milliliter to tens of milliliters range?", "Can you see masses that might have a low protein content in their fluid, similar to lymph?", "Are there areas with a cellular makeup including lymphatic endothelial cells, fibroblasts, or occasional inflammatory cells?", "Does the affected tissue appear to have lower density than surrounding normal tissue, possibly due to fluid-filled spaces?", "Are any of the lesions irregular or multiloculated in shape?", "Can you identify structures that might have a high water content, consistent with serous fluid?", "Is there evidence of tissue with low lipid content, except in regions that could contain chylous fluid?", "Do any of the lesions appear to have a soft, spongy, or cystic texture?", "Are there masses that seem to grow slowly and progressively over time?", "Can you see lesions that would be expected to have a neutral to slightly alkaline pH in their fluid?", "Are there areas with low vascularity, suggesting the presence of lymphatic rather than blood vessels?"], "relational": ["Does the image show evidence of abnormal changes within the lymphatic system?", "Can you identify any alterations in lymphatic vessels or connective tissue?", "Is there a visible abnormality affecting the respiratory or skeletal systems?", "Does the image reveal involvement of anatomical regions such as the thorax, abdomen, bones, or skin?", "Are there signs of altered lymphatic capillaries or collecting lymphatic vessels?", "Can you see any lesions present in the pleural or peritoneal cavity, or the mediastinum?", "Is there evidence of abnormal proliferation within lymphatic structures?", "Does the image show changes in organs like the lungs, liver, spleen, or bones?", "Are there visible abnormalities in tissues adjacent to blood vessels, nerves, or muscles?", "Can you identify any interactions between affected tissues and the circulatory, immune, or musculoskeletal systems?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal proliferation of vessels that could indicate multi-organ dysfunction?", "Can you identify any signs of vessel obstruction or malformation that might disrupt normal drainage?", "Is there visible fluid retention or swelling in tissues suggestive of impaired lymphatic function?", "Does the image display features consistent with impaired migration of immune cells due to blocked lymphatic pathways?", "Are there indications of excessive vessel growth or structural abnormalities affecting normal vessel function?", "Can you observe tissue swelling or edema that could result from poor lymphatic drainage?", "Is there evidence of impaired absorption of dietary fats, such as changes in intestinal structures responsible for chylomicron transport?", "Does the image suggest reduced clearance of waste products from tissues, possibly due to lymphatic dysfunction?", "Are there signs that immune surveillance might be decreased, such as limited movement of antigen-presenting cells or lymphocytes?", "Can you see features that would indicate increased interstitial fluid pressure resulting from disrupted drainage and fluid accumulation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see any anatomical features associated with the passage of the vertebral arteries or occipital vein?", "Does the image contain a structure featuring a large opening for the passage of the spinal cord?", "Can you identify occipital condyles that would articulate with the first cervical vertebra?"], "contexual_behavior": ["Can you identify a region of the skull where a fracture might alter cranial stability due to loss of bone continuity?", "Is there evidence of a bone in the posterior skull region where reduced mineral density could indicate compromised structural support, as seen in osteoporosis?", "Does the image show any signs of weakened bone structure in the posterior skull that could be associated with osteomyelitis or other bone infections?"], "functions": ["Does the image show a bone that articulates with the parietal, temporal, and sphenoid bones to maintain cranial stability?", "Does the image include a bone forming the posterior base of the cranial cavity?", "Is there evidence of an articulation that allows for nodding movements of the head?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": ["Are there signs of delayed bone healing, such as lack of bridging callus or persistent fracture lines, possibly due to poor vascularity or infection?", "Are there changes in limb length, such as shortening, due to overriding bone fragments or bone loss?", "Is there evidence of increased local temperature or redness, indicating hyperemia during the acute inflammatory phase?"], "properties": ["Can you observe swelling near the site of injury measuring about 3 to 8 centimeters in diameter?", "Do the bone breaks appear to be of transverse, oblique, or comminuted pattern?", "Can you identify bone fragments that are each between 2 and 10 centimeters in length?"], "relational": ["Can you see affected regions in the limbs, spine, or skull that suggest more than one bone is involved?", "Are there signs of injury in flat bones or the pelvis?", "Are there features suggesting the participation of bone marrow or blood vessels in the healing process at multiple sites?"], "contexual_behavior": [], "functions": ["Can you observe features that might indicate delayed bone healing, such as abnormal alignment or persistent gaps at multiple injury sites?", "Is there evidence of tissue ischemia or impaired perfusion in areas affected by more than one injury?", "Can you identify signs that tissue repair or regeneration may be impaired, such as persistent wounds or delayed closure at multiple sites?"]}}}
[ { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "no", "extracted_concepts": [ "oat cell", "metastatic carcinoma" ], "question": "is metastatic carcinoma oat cell present?" }, { "answer": "potters facies", "extracted_concepts": [ "potters facies" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "potters facies" ], "question": "is potters facies present?" }, { "answer": "no", "extracted_concepts": [ "normal palmar creases" ], "question": "is normal palmar creases present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "potters facies", "extracted_concepts": [ "potters facies" ], "question": "what is present?" } ]	["metastatic carcinoma", "normal palmar creases", "oat cell", "face", "potters facies"]	{"metastatic carcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show abnormal tissue invading connective, muscle, epithelial, or nervous tissue?", "Can you identify lesions affecting organs such as the liver, lungs, bones, or brain?", "Is there evidence of abnormal cells utilizing lymphatic vessels or lymph nodes to reach distant sites?", "Does the image suggest a possible origin from tissues like breast, lung, colon, prostate, or skin?", "Can you see signs of disease spreading through the circulatory or lymphatic systems?", "Is there a structure that appears to facilitate the movement of abnormal cells, such as blood vessels, lymphatic vessels, or basement membrane disruption?", "Are there visible abnormalities in regions commonly targeted by secondary tumors, such as the liver, lungs, bones, brain, or lymph nodes?", "Does the image show abnormal cells interacting with or invading blood vessels or capillaries?", "Is there evidence of cells crossing anatomical barriers like the basement membrane, endothelial barriers, or the blood-brain barrier?", "Can you identify both a primary lesion and a separate secondary lesion, suggesting the spread of malignant cells from one site to another?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal cell clusters invading surrounding tissues?", "Can you identify areas where healthy tissue appears to be replaced or disrupted, potentially impairing organ function?", "Is there visual evidence of tissue structures being breached, such as the basement membrane or extracellular matrix?", "Does the image reveal signs of new blood vessel formation that could be stimulated by pro-angiogenic factors?", "Can you see regions where the local tissue environment appears altered, such as increased stromal cell presence or changes in matrix composition?", "Is there evidence of immune cell infiltration or inflammation, possibly due to cytokine release?", "Does the image display features suggestive of fibroblast activation or increased matrix metalloproteinase activity?", "Are there signs of abnormal cellular proliferation or expansion beyond normal tissue boundaries?", "Can you observe areas that might indicate hypoxia or nutrient competition, such as poorly vascularized or necrotic regions?", "Is there visual indication of organ dysfunction or structural compromise, such as distortion or loss of normal architecture?", "Does the image suggest the presence of cells that may be resisting apoptosis or exhibiting survival advantages?", "Can you identify features that could be associated with altered growth factor signaling or disrupted intercellular communication?", "Is there evidence of metastatic spread, such as abnormal cell clusters present in distant organs or tissues?", "Does the image show signs of cachexia or systemic metabolic effects, such as tissue wasting or loss of normal tissue mass?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show something associated with bones such as the femur, tibia, humerus, or spine?", "Is there an object positioned near arteries, veins, or capillaries?", "Does the image show an object present within the musculoskeletal, cardiovascular, nervous, or reproductive systems?"], "contexual_behavior": [], "functions": ["Is there a structure that could act as a scaffold or fixation device to promote bone healing or regeneration?", "Can you see an object that appears to integrate with biological tissue or form a mechanical or biochemical interface?", "Does the image contain an object that reinforces or stabilizes bones, joints, or soft tissues?"]}}, "normal palmar creases": {"yes_questions": {"contexual_properties": ["Does the image show any features that become deeper with repeated hand movement or increased skin tension?", "Can you identify areas that appear shallower, possibly due to swelling or reduced hand mobility?", "Is there evidence of color changes that could be related to vascular alterations, bruising, or skin conditions?", "Do any lines appear more prominent, which might suggest dehydration, weight loss, or frequent manual activity?", "Are there regions where these features are less visible, potentially due to swelling, thickened skin, or increased subcutaneous fat?", "Can you observe any widening of these lines that might be associated with chronic swelling, connective tissue disorders, or past trauma?", "Are there any areas where the lines appear narrowed, possibly as a result of skin tightening, scarring, or fibrosis?", "Do you see interruptions in these features that could be due to scarring, injury, or congenital differences?", "Is there any distortion of these lines, which might indicate burns, contractures, or severe skin disease?", "Are there signs of swelling along these features that could suggest local inflammation, infection, or an allergic reaction?", "Do any of these lines appear red, possibly due to irritation, dermatitis, or increased blood flow?", "Can you see areas that look dry or cracked, which might be related to low humidity, eczema, or frequent washing?", "Are there regions where these features look thickened, potentially from chronic friction, callus formation, or skin disorders?", "Do any of these lines appear pale, which could be a sign of anemia, poor circulation, or vasoconstriction?", "Is there evidence of pigmentation changes along these features, possibly due to sun exposure, hormonal shifts, or skin disease?"], "properties": ["Does the image show three distinct lines on the anterior surface of the hand, including both longitudinal and transverse orientations?", "Can you identify an M-shaped arrangement formed by curved or arched lines across the palm?", "Are there grooves on the palm that appear to be between 4 and 8 centimeters in length, depending on hand size?", "Do the visible lines on the palm have a width of approximately 1 to 3 millimeters?", "Are the grooves on the palm shallow, with a depth of about 0.5 to 1 millimeter?", "Is there a smooth but slightly indented texture along the main lines of the palm compared to the surrounding skin?", "Do the main lines on the palm appear slightly lighter or similar in color to the adjacent palmar skin?", "Can you observe that the distance between the primary lines on the palm is about 1 to 2 centimeters apart?", "Are the main lines on the palm following a curved or arched path along the natural contours of the hand?"], "relational": ["Does the image show the anterior surface of the hand with visible lines in the palmar region?", "Can you identify features adjacent to the palmar skin, such as digital pads or the thenar and hypothenar eminences?", "Is there evidence of surface markings formed by the epidermis and dermis layers of the skin on the palm?", "Can you see any lines that overlie the metacarpal bones or proximal phalanges?", "Are there visible features on the palm that correspond to the location of underlying muscles like the flexor digitorum superficialis or lumbricals?", "Does the image include areas supplied by the superficial palmar arch or palmar digital arteries?", "Can you identify lines or creases that are associated with the metacarpophalangeal or interphalangeal joints?", "Are there markings on the palm that demarcate the flexion lines at the base or along the length of the fingers?", "Is there a structure present that is part of the palm and, by extension, the hand?", "Can you see any features on the palm that are situated near the course of the median or ulnar nerves?"], "contexual_behavior": ["Is there evidence of skin folds on the palm that appear less defined, possibly due to increased hydration or swelling?", "Can you identify deeper skin lines on the palm that might suggest repetitive manual labor or increased mechanical stress?", "Does the image show palm skin lines that are less prominent, which could be associated with connective tissue disorders affecting collagen?", "Are there alterations in the pattern of palm skin folds that might indicate chronic swelling or persistent edema?", "Do the palm skin lines appear more visible, as might be seen after prolonged immersion in water?", "Is there a loss of typical skin fold function as flexion guides, potentially due to reduced elasticity from conditions like scleroderma?", "Can you observe changes in the appearance of palm skin lines that could be due to acute inflammation, such as swelling or redness obscuring the usual patterns?", "Do the palm skin folds appear less functional in guiding hand movement, possibly as a result of severe edema restricting mobility?", "Is there evidence of impaired flexibility in the palm skin lines, as might be seen in aging with reduced collagen and elastin?", "Are the palm skin lines more pronounced, which could be due to low subcutaneous fat making the folds more visible?"], "functions": ["Does the image show features that enhance the flexibility and range of motion of the palm?", "Can you identify structures that allow the skin to fold smoothly during hand movement?", "Is there evidence of adaptations that improve grip by enabling the skin to conform to objects?", "Does the image display characteristics that increase the pliability of the palmar skin for dynamic hand shape changes?", "Can you see features that help maintain the alignment of sensory receptors for precise tactile feedback?", "Is there a visible pattern that distributes mechanical stress during hand movement to protect the skin?", "Does the image show adaptations that enable intricate finger and palm movements required for fine motor skills?", "Can you identify natural hinge lines in the skin that facilitate folding and extension of the palm?"]}, "no_questions": {"contexual_properties": ["Do any masses exhibit a change in shape, which could be related to tumor invasion, growth, or treatment effects?", "Does the image show any masses that appear larger than expected, suggesting possible tumor growth or disease progression?", "Do any masses have more indistinct margins, which might be caused by infiltrative growth or edema?"], "properties": ["Is there a region that appears as a slightly increased opacity relative to the background?", "Are calcifications rarely or infrequently observed within any of the subtle masses present?", "Is there only one such irregular area present in the image, rather than multiple similar findings?"], "relational": ["Does the image show a region where the adjacent parenchyma, lobules, or terminal ductal lobular units appear affected by an irregular mass?", "Does the image show a region of dense or heterogeneously dense parenchyma with an irregular feature?", "Can you identify a mass-like feature that appears within the breast parenchyma or mammary glands?"], "contexual_behavior": ["Can you see a region where post-surgical scarring makes it difficult to identify or distinguish a mass from surrounding tissue?", "Does the image contain a mass that is less distinguishable, potentially as a result of chemotherapy-induced changes in tissue contrast?", "Is there a lesion whose clinical significance appears reduced, possibly following a benign biopsy result?"], "functions": ["Can you see any areas where the normal ductal or lobular architecture is disrupted?", "Are there subtle regions that appear denser or stiffer than the surrounding tissue?", "Does the image show any areas that could serve as early radiological markers for pathological changes?"]}}, "oat cell": {"yes_questions": {"contexual_properties": ["Does the image show cells that have increased in size, possibly due to hypertrophy or malignant transformation?", "Can you identify cells that appear reduced in size, which might indicate atrophy or a response to cytotoxic treatment?", "Are there cells with altered shapes, suggesting mitosis or neoplastic progression?", "Does the image contain areas where a particular cell type is more numerous, consistent with rapid tumor proliferation or metastatic spread?", "Can you observe cells with abnormal nuclear features, which could be associated with malignancy or high-grade tumor progression?", "Are there cells with changes in their cytoplasmic composition, possibly due to metabolic reprogramming or exposure to chemotherapeutic agents?", "Do you see cells with increased chromatin accumulation, indicating heightened nuclear activity or mitotic abnormalities?", "Is there evidence of densely packed cells within tissue, suggesting tumor mass expansion or stromal invasion?", "Can you identify an increased number of mitotic figures, which may be a sign of rapid cell division or aggressive tumor growth?", "Are there cells exhibiting cytoplasmic granules, which could indicate neuroendocrine differentiation or secretory activity?", "Do any cells display altered staining properties, possibly due to special stains or changes in cellular composition?", "Can you find multinucleated cells, which might result from abnormal mitosis or cell fusion events?", "Are there cells with reduced cytoplasmic volume, consistent with apoptosis or necrosis?", "Is there evidence of necrotic changes in cells, potentially due to hypoxia or cytotoxic injury?", "Do you observe cells with an increased nuclear-to-cytoplasmic ratio, as seen in malignant transformation or high-grade tumors?", "Are there cells showing vacuolization, which could be due to degenerative changes or autophagic processes?", "Can you identify cells with increased pleomorphism, possibly reflecting tumor progression or genetic instability?", "Are there cells with abnormal surface markers, which may result from malignant transformation or genetic mutations?", "Do you see areas where cell density is increased, suggesting tumor growth or cellular crowding?", "Are there cells with altered membrane properties, potentially due to oncogenic transformation or therapeutic intervention?"], "properties": ["Does the image show cells that are unusually small, measuring between 2 and 4 micrometers in diameter?", "Can you identify cells with an elongated or oval shape, resembling grains of oats?", "Are there cells present with a high nuclear-to-cytoplasmic ratio, where the nucleus occupies most of the cell?", "Do you observe cells with finely granular and evenly distributed chromatin?", "Is there evidence of cells with scant, basophilic cytoplasm under light microscopy?", "Can you see cells where nucleoli are absent or inconspicuous?", "Are there cells that stain intensely with hematoxylin and eosin, showing dark nuclei and scant pale cytoplasm?", "Does the image contain cells exhibiting a high mitotic rate, with frequent mitotic figures visible?", "Are there cells that appear blue to purple due to basophilic staining properties?", "Do you observe densely packed cells forming sheets or clusters in the tissue sample?", "Are there cells with nuclei measuring approximately 1.5 to 2.5 micrometers in diameter?", "Can you identify arrangements of cells in sheets, clusters, or as single cells with evidence of nuclear molding?", "Are there cells with cytoplasm that contains few or no granules?", "Do you see cells with smooth and delicate cytoplasmic texture?", "Is there evidence of cell organelles displaying moderate electron density on ultrastructural examination?"], "relational": ["Does the image show a malignant cell type associated with the respiratory system?", "Is there evidence of neuroendocrine tissue within epithelial structures in the thoracic region?", "Can you identify abnormal cells located in or near bronchial or pulmonary structures?", "Does the image reveal tumor masses or nodules within lung parenchyma?", "Is there a cluster of cells forming a tumor predominantly in the lungs?", "Can you see cells with prominent nuclei, cytoplasm, and possible neurosecretory granules?", "Is there a tumor mass that could be classified as a small cell lung carcinoma?", "Are there malignant cells that may have spread to the mediastinum or distant organs?", "Does the image show a region where lymphocytes, fibroblasts, or endothelial cells are found adjacent to abnormal cell clusters?", "Can you identify a structure in the thoracic region that is affected by malignancy originating in the lung?"], "contexual_behavior": ["Does the image show evidence of cells with abnormal hormone secretion that could be linked to paraneoplastic syndromes?", "Can you identify cells that might exhibit impaired regulation of cell growth, suggesting malignant transformation or tumor progression?", "Is there a visible indication of accelerated cell proliferation that could be associated with exposure to carcinogens such as tobacco smoke?", "Does the image contain cells with features of neuroendocrine dysregulation, as seen in certain aggressive lung cancers?", "Can you observe a decrease in programmed cell death, possibly due to upregulation of anti-apoptotic pathways in a malignant context?", "Is there evidence of cells that might display resistance to chemotherapy-induced stress, suggesting adaptation during cancer treatment?", "Does the image suggest increased secretion of hormones that could be responsible for paraneoplastic syndromes in a malignant setting?", "Can you see signs of disrupted tissue architecture, such as loss of cell adhesion or invasion into surrounding tissue, indicative of cancer development?", "Is there evidence of intensified invasive behavior in regions that might be experiencing low oxygen levels?", "Does the image show cells with increased glycolytic activity or metabolic adaptation in response to nutrient deprivation?", "Can you identify features suggesting enhanced immune evasion, such as increased PD-L1 expression, during tumor progression?", "Is there a visible loss of cellular differentiation, with cells appearing more undifferentiated in advanced disease?", "Does the image suggest impaired DNA repair mechanisms, possibly as a result of radiation exposure leading to genomic instability?", "Can you observe features consistent with increased metastatic potential, such as enhanced cell motility or invasion in late-stage disease?", "Is there evidence that secretion of growth factors by certain cells has changed, possibly as an adaptation to targeted therapy?"], "functions": ["Does the image show cells exhibiting features of malignant neuroendocrine activity?", "Can you identify a population of cells associated with rapid tumor growth and aggressive cancer progression?", "Are there cells present that display high mitotic activity or resistance to programmed cell death?", "Does the image contain cells that could be responsible for ectopic hormone production, potentially leading to paraneoplastic syndromes such as SIADH or Cushing\u2019s syndrome?", "Can you see evidence of cells that might evade immune detection through reduced antigen presentation or secretion of immunosuppressive factors?", "Is there visual indication of cells invading blood vessels or lymphatics, suggesting the potential for metastatic spread?", "Are there cells infiltrating surrounding tissues, possibly through degradation of the extracellular matrix?", "Can you identify cellular features consistent with dysregulation of oncogenes or inhibition of apoptosis?", "Does the image show evidence of cells that might contribute to resistance against chemotherapy, such as by expressing drug efflux pumps or altering DNA repair?", "Are there signs of tumor microenvironment modification, such as recruitment of stromal cells or new blood vessel formation (angiogenesis)?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image suggest possible spread through lymphatic vessels, venous plexuses, or by direct extension?", "Can you identify an abnormality involving glandular epithelial tissue surrounded by prostatic stroma?", "Does the image show a lesion originating within a gland of the male reproductive system?"], "contexual_behavior": [], "functions": []}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": ["Is there evidence of a substance that would become more diluted if additional solvent, such as water, were mixed in?", "Is there a depiction of the stomach where the content of a particular substance increases after food intake or stimulation by a hormone?", "Does the image show a container where the volume of a liquid could increase by adding more solute or solvent?"], "properties": ["Is there an object that could melt at temperatures like \u2212114\u00b0C or 10\u00b0C?", "Is there a solution or liquid that would likely conduct electricity well due to ionization?", "Can you see a substance that might boil at around 110\u00b0C or 337\u00b0C?"], "relational": ["Can you identify organs or tissues involved in regulating the concentration of hydrogen ions, such as the kidneys or lungs?", "Does the image show anatomical compartments where acid-base balance is maintained, such as blood plasma or interstitial fluid?", "Is there a visible organ known for secreting substances that lower pH, such as the stomach or kidneys?"], "contexual_behavior": [], "functions": ["Does the image show a process or structure that could be involved in denaturing proteins?", "Is there evidence of a substance in the image that contributes to the breakdown of food during digestion?", "Can you identify a component that might disrupt hydrogen bonds to alter protein structure?"]}}, "potters facies": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a face with a flattened and broad nasal bridge?", "Can you identify a small and receding chin in the image?", "Is there evidence of widely spaced eyes or increased distance between the eyes?", "Does the face appear to have flat cheeks or poorly defined cheekbones?", "Are the ears positioned lower than usual or do they appear abnormally shaped?", "Is the mouth downturned or does it have a small oral opening?", "Can you observe loose or wrinkled skin, especially around the face?", "Does the skin color appear normal or is there any sign of pallor?", "Are prominent epicanthal folds visible near the eyes?", "Is there a marked degree of micrognathia present?", "Do the lips appear thin or pursed?", "Are multiple facial features flattened or lacking normal contour?"], "relational": ["Does the image show facial features such as a flattened nasal bridge or recessed chin?", "Can you identify low-set ears or epicanthal folds in the facial structures present?", "Is there evidence of abnormalities in the midface, periorbital region, or mandibular area?", "Are there visible alterations in the skin, subcutaneous tissue, or cartilage of the face?", "Does the image reveal skeletal changes involving the mandible, maxilla, or nasal bones?", "Can you observe features that might suggest an association with conditions like Potter sequence or bilateral absence of kidneys?", "Is there any indication of developmental issues such as oligohydramnios reflected in the facial appearance?", "Are there signs of anomalies in the craniofacial system that could be linked to the urinary system?", "Does the image show other congenital anomalies such as limb deformities, underdeveloped lungs, or clubfoot?"], "contexual_behavior": ["Does the image show facial features that could be associated with prolonged or severe deficiency of amniotic fluid during gestation?", "Are there signs of facial changes that might be less pronounced if some renal function and amniotic fluid volume were preserved?", "Can you identify a face that appears unaffected, possibly indicating that any reduction in amniotic fluid was only temporary and resolved before critical development periods?", "Is there evidence of facial characteristics that could be modified or overlapped due to the presence of another craniofacial syndrome?", "Does the image suggest more severe facial alterations that might result from early-onset absence of kidney development and extended periods of low amniotic fluid?", "Are there facial features that appear less distinct, potentially indicating that amniotic fluid levels normalized before mid-gestation?", "Can you see facial variations that might be explained by amniotic fluid loss from causes other than kidney problems, such as chronic leakage?", "Does the image lack the typical facial changes expected when urinary tract obstruction is mild and amniotic fluid remains sufficient?", "Are there visual signs of severe facial flattening that could be linked to impaired airway passages?", "Is there evidence of malformations around the mouth or nose that might contribute to feeding or breathing difficulties in a newborn?"], "functions": ["Does the image show a newborn with facial features that could compromise breathing or cause airway obstruction?", "Is there evidence of facial structure that might interfere with feeding or sucking ability in an infant?", "Can you identify features that suggest an increased risk of aspiration due to altered protective facial anatomy?", "Does the image reveal signs of limited facial muscle function, such as reduced mobility or weakness?", "Is there any indication of oral or facial malformations that could delay or impair speech development?", "Do you observe eyelid abnormalities or reduced facial tone that might hinder effective blinking or eye protection?", "Is there visual evidence of poor oral competence, such as drooling or difficulty controlling saliva?", "Does the facial appearance suggest diminished ability to express emotions or reduced facial expressivity?"]}, "no_questions": {"contexual_properties": ["Is there a structure in the image that appears to be attached to an ovary on the opposite side?", "Can you identify any tissue or anatomical feature that is visually continuous with an ovary across to the other side?", "Does the image show evidence of a structure adhering to an ovary located on the contralateral side?"], "properties": ["Is there a connective tissue near the ovary that likely contains fibroblasts, mesothelial cells, or inflammatory cells?", "Is there a structure near the ovary on the opposite side that appears irregular or band-shaped?", "Is there evidence of tissue with low to moderate density and sparse blood vessels near the ovary on the opposite side?"], "relational": ["Does the image show any abnormal attachment involving the suspensory ligament of the ovary and a neighboring pelvic organ?", "Can you identify any evidence of adhesion between a pelvic peritoneal surface and an organ near the lateral pelvic wall?", "Does the image show any evidence of the ovarian artery or vein being involved in an adhesion with adjacent tissues?"], "contexual_behavior": ["Is there a structure in the image that appears to be attached to an ovary located on the opposite side?", "Can you identify any tissue or anatomical feature that seems to be physically connected to an ovary across from it?", "Does the image show evidence of an anatomical entity adhering to an adjacent ovary on the contralateral side?"], "functions": ["Is there a visible disruption in the normal pathway for gamete movement or evidence of a physical barrier affecting egg transport?", "Can you identify any mechanical obstruction or altered positioning of reproductive organs that could impact reproductive processes?", "Is there evidence of an adhesion that might disrupt blood flow or interfere with follicular development in an ovary?"]}}}
[ { "answer": "view of low set ears", "extracted_concepts": [ "low set ears" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "low set ears" ], "question": "does this image show view of low set ears?" }, { "answer": "no", "extracted_concepts": [ "premature coronary disease", "low set ears" ], "question": "does premature coronary disease show view of low set ears?" }, { "answer": "potters facies", "extracted_concepts": [ "potters facies" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "potters facies" ], "question": "is potters facies present?" }, { "answer": "no", "extracted_concepts": [], "question": "is sets present?" }, { "answer": "potters facies", "extracted_concepts": [ "potters facies" ], "question": "what is present?" } ]	["premature coronary disease", "potters facies", "low set ears"]	{"premature coronary disease": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of early pathological changes in the vessels supplying blood to the heart muscle?", "Can you identify any narrowing or abnormalities in arteries such as the left anterior descending, right coronary, or left circumflex artery?", "Is there a visible indication of accelerated atherosclerosis in the coronary circulation?", "Does the image reveal compromised cardiac muscle tissue or vascular endothelium?", "Are there signs of affected regions within the myocardium, such as the left ventricular wall or interventricular septum?", "Can you see any structural changes in the heart muscle that might suggest early onset disease in individuals below a typical age threshold?", "Is there evidence of involvement of the cardiac conduction system or subendocardial regions?", "Does the image display any relationship between the coronary arteries and larger cardiovascular structures like the aorta, left ventricle, or right atrium?", "Are there features present that indicate the cardiovascular system is primarily affected?"], "contexual_behavior": [], "functions": ["Is there evidence of reduced patency in the coronary arteries, such as visible narrowing or blockage?", "Can you identify signs of impaired blood flow to the heart muscle, such as regions suggestive of myocardial ischemia?", "Does the image show features consistent with early-onset atherosclerosis or arterial stenosis in the coronary vessels?", "Is there any indication of decreased oxygen delivery to cardiac tissue, such as areas of hypoperfusion or hypoxia?", "Can you observe structural or functional changes in the heart muscle that might indicate contractile dysfunction or systolic impairment?", "Are there visual cues suggesting transient ischemia or regions that could be associated with angina pectoris?", "Does the image reveal any signs of plaque rupture or thrombotic events within the coronary arteries?", "Is there evidence of myocardial infarction, such as localized tissue damage or scarring in the heart?", "Can you detect abnormalities in the cardiac conduction system or features that might suggest arrhythmias?", "Are there indications that the heart\u2019s ability to increase output during physical stress is compromised, such as reduced cardiac reserve?", "Does the image show structural changes or dysfunction that could contribute to heart failure or ventricular impairment?", "Is there any evidence of impaired blood pressure regulation, such as signs of hemodynamic instability or altered cardiac output?", "Can you identify features that might explain exercise intolerance, such as reduced endurance capacity or exertional angina?", "Are there visual signs of impaired healing in the heart tissue, such as fibrosis or scar formation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify supporting structures such as a plantar plate, collateral ligaments, or sesamoid ligaments in the medial forefoot?", "Is there a joint visible that could correspond to either a metatarsophalangeal or interphalangeal joint of the hallux?", "Does the image include a region where muscles such as the flexor hallucis longus, extensor hallucis longus, or abductor hallucis might attach?"], "contexual_behavior": [], "functions": ["Does the image show something that enables precise adjustments in toe positioning and grip for fine motor control of the foot?", "Does the image show a part that plays a crucial role in walking or running by enabling effective push-off?", "Can you see something that helps maintain posture by stabilizing the foot and supporting the body's upright position?"]}}, "potters facies": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a face with a flattened and broad nasal bridge?", "Can you identify a small and receding chin in the image?", "Is there evidence of widely spaced eyes or increased distance between the eyes?", "Does the face appear to have flat cheeks or poorly defined cheekbones?", "Are the ears positioned lower than usual or do they appear abnormally shaped?", "Is the mouth downturned or does it have a small oral opening?", "Can you observe loose or wrinkled skin, especially around the face?", "Does the skin color appear normal or is there any sign of pallor?", "Are prominent epicanthal folds visible near the eyes?", "Is there a marked degree of micrognathia present?", "Do the lips appear thin or pursed?", "Are multiple facial features flattened or lacking normal contour?"], "relational": ["Does the image show facial features such as a flattened nasal bridge or recessed chin?", "Can you identify low-set ears or epicanthal folds in the facial structures present?", "Is there evidence of abnormalities in the midface, periorbital region, or mandibular area?", "Are there visible alterations in the skin, subcutaneous tissue, or cartilage of the face?", "Does the image reveal skeletal changes involving the mandible, maxilla, or nasal bones?", "Can you observe features that might suggest an association with conditions like Potter sequence or bilateral absence of kidneys?", "Is there any indication of developmental issues such as oligohydramnios reflected in the facial appearance?", "Are there signs of anomalies in the craniofacial system that could be linked to the urinary system?", "Does the image show other congenital anomalies such as limb deformities, underdeveloped lungs, or clubfoot?"], "contexual_behavior": ["Does the image show facial features that could be associated with prolonged or severe deficiency of amniotic fluid during gestation?", "Are there signs of facial changes that might be less pronounced if some renal function and amniotic fluid volume were preserved?", "Can you identify a face that appears unaffected, possibly indicating that any reduction in amniotic fluid was only temporary and resolved before critical development periods?", "Is there evidence of facial characteristics that could be modified or overlapped due to the presence of another craniofacial syndrome?", "Does the image suggest more severe facial alterations that might result from early-onset absence of kidney development and extended periods of low amniotic fluid?", "Are there facial features that appear less distinct, potentially indicating that amniotic fluid levels normalized before mid-gestation?", "Can you see facial variations that might be explained by amniotic fluid loss from causes other than kidney problems, such as chronic leakage?", "Does the image lack the typical facial changes expected when urinary tract obstruction is mild and amniotic fluid remains sufficient?", "Are there visual signs of severe facial flattening that could be linked to impaired airway passages?", "Is there evidence of malformations around the mouth or nose that might contribute to feeding or breathing difficulties in a newborn?"], "functions": ["Does the image show a newborn with facial features that could compromise breathing or cause airway obstruction?", "Is there evidence of facial structure that might interfere with feeding or sucking ability in an infant?", "Can you identify features that suggest an increased risk of aspiration due to altered protective facial anatomy?", "Does the image reveal signs of limited facial muscle function, such as reduced mobility or weakness?", "Is there any indication of oral or facial malformations that could delay or impair speech development?", "Do you observe eyelid abnormalities or reduced facial tone that might hinder effective blinking or eye protection?", "Is there visual evidence of poor oral competence, such as drooling or difficulty controlling saliva?", "Does the facial appearance suggest diminished ability to express emotions or reduced facial expressivity?"]}, "no_questions": {"contexual_properties": ["Is there increased vascularity in a tube adjacent to the ovary, suggesting acute inflammation or a neoplastic process?", "Is there evidence of fibrous tissue formation in a tube adherent to the ovary, possibly resulting from chronic inflammation and healing?", "Does the image show a tube next to the ovary with color changes that could be due to hemorrhage, ischemia, or necrosis?"], "properties": ["Does the image include a structure with moderate vascularity and a rich capillary network?", "Is there a structure where fibrosis appears minimal under normal conditions?", "Does the image show a structure with considerable elasticity, allowing for distension and contraction?"], "relational": ["Is there a structure in the reproductive tract that communicates with the uterus at the uterine horn?", "Does the image show a structure located near the ovary, uterus, urinary bladder, or rectum within the pelvic region?", "Can you identify a tube-like structure in the pelvic region that is in direct contact with an ovary on the opposite side?"], "contexual_behavior": ["Does the image show a tube that may fail to support embryo transport due to mechanical obstruction or loss of coordinated motility from pelvic adhesions?", "Is there a structure present that, if its patency or function is compromised, could increase the risk of ectopic implantation due to embryo retention?", "Is there visual evidence of anatomical distortion or fibrosis in a tube-like structure, suggesting dysfunction possibly related to endometriosis?"], "functions": ["Is there evidence of impaired ciliary motion or reduced motility in a tube adjacent to the ovary due to adherence?", "Can you see any indication of mechanical obstruction or altered function in a tube that could lead to infertility?", "Does the image show a tube whose adherence to the ovary might impair the clearance of peritoneal fluid by restricting normal drainage or mobility?"]}}, "low set ears": {"yes_questions": {"contexual_properties": ["Does the image show an auricular structure that appears more prominent during periods of rapid growth or in the presence of craniofacial anomalies?", "Can you identify an ear that looks swollen, possibly due to local infection, trauma, or an allergic reaction?", "Is there an auricular region displaying color changes suggestive of inflammation, bruising, or a vascular disorder?", "Does the image reveal an ear with abnormal shape, potentially associated with a congenital syndrome or developmental defect?", "Can you see an ear with unusual creases that might indicate a genetic condition such as Down syndrome or the effects of chronic pressure?", "Is there evidence of asymmetry between the ears, possibly due to unilateral developmental anomalies or trauma?", "Does any ear appear red or inflamed, which could be a sign of cellulitis, otitis externa, or dermatitis?", "Can you observe changes in ear size that might result from edema, growth abnormalities, or neoplastic processes?", "Is there an auricular area with skin lesions consistent with dermatological conditions like eczema, psoriasis, or infection?", "Does any ear appear edematous, suggesting an allergic reaction, infection, or systemic disease causing fluid retention?", "Can you detect alterations in cartilage structure of the ear, possibly due to congenital malformations, trauma, or degenerative disease?", "Is there evidence of discoloration in the ear, such as bruising, cyanosis, or signs of vascular compromise?", "Does the image show abnormal tissue growth on the ear, which could be due to neoplastic conditions, keloid formation, or chronic inflammation?", "Can you identify thickening of the auricle that might result from chronic inflammation, repeated trauma, or cartilage disorders?", "Is there loss of normal ear contour, possibly due to scarring, congenital deformities, or previous surgical intervention?"], "properties": ["Is there a structure on the side of the head positioned below an imaginary horizontal line connecting the inner corners of the eyes to the back of the head?", "Can you identify an object whose superior attachment lies beneath the horizontal plane passing through the inner canthi?", "Does the image show a feature attached at an angle greater than 15 degrees from the vertical plane of the head?", "Is there a structure with a length between 6 and 6.5 centimeters, consistent with typical measurements for this region?", "Can you see an object with a width of about 3 centimeters, matching the average for this anatomical area?", "Is there a visible structure that maintains normal auricular features such as the helix, antihelix, and lobule?", "Does the distance between this structure and the eyes appear increased compared to typical facial proportions?", "Can you observe a region whose skin color matches the surrounding facial skin, ranging from light pink to brown depending on pigmentation?", "Is there a structure with a smooth skin texture similar to adjacent facial areas?"], "relational": ["Does the image show an abnormality affecting the lateral aspect of the craniofacial region?", "Can you identify a structure adjacent to the mandible, mastoid process, or zygomatic arch that appears unusual?", "Is there evidence of craniofacial features such as micrognathia, hypertelorism, or a flat nasal bridge?", "Does the auricle or pinna appear to be positioned differently compared to typical anatomy?", "Is there a visible relationship between the auricle and the temporal bone, mastoid process, or mandible that suggests abnormal placement?", "Can you see any indication that the first or second pharyngeal arch development may have influenced the positioning of external ear structures?", "Does the image contain features commonly seen in syndromes such as Down syndrome, Turner syndrome, or Edwards syndrome?", "Is there evidence of mandibular hypoplasia or abnormal jaw development in the craniofacial region?", "Can you assess the position of the auricle relative to the cantho-occipital or canthotragal lines?", "Are there other ear anomalies present, such as microtia, posteriorly rotated ears, or preauricular tags?"], "contexual_behavior": ["Does the image show an external ear whose position might disrupt the alignment of the pinnae relative to the auditory axis, potentially affecting sound localization?", "Is there evidence of an ear structure that could be associated with hearing difficulties due to malformations of the ear or auditory canal, as seen in certain syndromes?", "Can you identify an external ear whose orientation or structure appears altered in a way that might suggest a craniofacial developmental disorder?", "Does the anatomical position of the external ear in the image appear to expose the ear canal to increased risk of trauma or infection?", "Is there an auricle that has not ascended to its typical location, possibly indicating impaired embryological positioning during fetal development?", "Does the image contain an external ear whose displacement or angle could alter the effectiveness of sound wave collection?", "Can you see an ear whose position or associated features might suggest the presence of a genetic syndrome with additional auditory or craniofacial anomalies?", "Is there an external ear whose placement could disrupt the normal acoustic pathway to the ear canal, especially during head movement?", "Does the image show an ear whose position or orientation appears further altered by abnormal cranial growth?", "Can you identify an external ear whose atypical placement might interfere with the provision of normal anatomical cues for auditory processing, as seen in certain developmental disorders?"], "functions": ["Is there a visible feature that does not appear to impact hearing ability?", "Can you identify an anatomical variation that leaves sound localization unchanged?", "Does the image show an external ear whose protective function for the ear canal seems unaffected?", "Is there a feature present that would not be expected to alter ear drainage?", "Can you see an ear structure where the ability to funnel sound waves into the auditory canal appears preserved?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show an area of tissue that appears dark brown, black, or greenish in color?", "Does the tissue in any area appear to have reduced water content or seem unusually moist compared to surrounding areas?", "Does any tissue region appear to have low or high moisture levels, suggesting different types of tissue breakdown?"], "relational": ["Does the image show evidence of tissue damage affecting the skin, subcutaneous tissue, or muscle?", "Does the image suggest impaired blood flow, vascular occlusion, or ischemia in any region?", "Is there evidence of damage to epithelial, muscle, or endothelial cells in the depicted tissue?"], "contexual_behavior": [], "functions": ["Is there visible evidence of an exaggerated inflammatory response, such as leukocyte infiltration, cytokine release, or edema?", "Does the image show signs of disrupted blood supply, such as vascular occlusion or impaired perfusion?", "Can you observe features consistent with hypoxia, enzymatic degradation, or inflammatory damage to tissue?"]}}}
[ { "answer": "view of head with scalp", "extracted_concepts": [ "scalp", "head", "massive fractures" ], "question": "what retracted to show massive fractures?" }, { "answer": "to show massive fractures", "extracted_concepts": [ "scalp retracted", "massive fractures", "view of head" ], "question": "what is view of head with scalp retracted?" }, { "answer": "yes", "extracted_concepts": [ "scalp retracted", "scalp", "massive fractures", "view of head" ], "question": "is view of head with scalp retracted to show massive fractures?" }, { "answer": "no", "extracted_concepts": [ "endocrine", "massive fractures" ], "question": "is endocrine retracted to show massive fractures?" }, { "answer": "view of head with scalp retracted to show massive fractures", "extracted_concepts": [ "fractures", "head", "scalp", "massive fractures", "scalp retracted" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "scalp retracted", "head", "scalp", "massive fractures" ], "question": "does this image show view of head with scalp retracted to show massive fractures?" }, { "answer": "no", "extracted_concepts": [ "thecoma", "head", "scalp", "view of head", "massive fractures", "scalp retracted", "yellow foci" ], "question": "does this typical thecoma with yellow foci show view of head with scalp retracted to show massive fractures?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "muscle atrophy" ], "question": "is muscle atrophy present?" }, { "answer": "view of head with scalp", "extracted_concepts": [ "scalp", "head", "massive fractures", "view of head with scalp" ], "question": "what retracted to show massive fractures?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "massive", "extracted_concepts": [ "view of head with scalp retracted to show fractures", "head", "scalp", "fractures" ], "question": "how is view of head with scalp retracted to show fractures?" } ]	["fractures", "thecoma", "bone", "head", "scalp", "endocrine", "view of head", "muscle atrophy", "view of head with scalp retracted to show fractures", "massive fractures", "view of head with scalp", "calvarium", "scalp retracted", "yellow foci"]	{"fractures": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a disruption in the integrity of a structure that could be part of the musculoskeletal system?", "Can you identify any abnormality affecting long bones such as the femur, radius, or tibia?", "Is there evidence of a condition that might compromise mobility or structural support in the appendicular or axial skeleton?", "Does the image display changes in areas near joints like the knee, elbow, hip, or wrist?", "Can you see any involvement of anatomical landmarks such as the epiphysis, diaphysis, metaphysis, or articular surface?", "Is there a visible alteration in regions surrounded by muscle tissue, connective tissue, blood vessels, or skin?", "Does the image suggest an impact on organ systems like the circulatory or nervous system adjacent to a skeletal abnormality?", "Are there signs of stabilization by structures such as ligaments, muscles, periosteum, or external fixation devices?", "Can you detect abnormalities in bones that are weight-bearing or appear osteoporotic?", "Is there visual evidence of disruption near anatomical structures like blood vessels or nerves adjacent to a skeletal region?"], "contexual_behavior": [], "functions": ["Does the image show an area where bone continuity is lost, potentially compromising structural support?", "Can you identify a region where skeletal stability appears disrupted, possibly affecting weight bearing or mobility?", "Is there visual evidence of biological processes such as inflammation or callus formation at a site of bone injury?", "Does the image reveal signs of hematoma formation or accumulation of inflammatory cells near a bone defect?", "Can you see features suggesting debris clearance or recruitment of repair cells at a site of tissue regeneration?", "Is there an area where local blood vessels may be disrupted, leading to reduced perfusion or impaired healing?", "Does the image show a structure that could represent a stabilizing callus or scaffold for new bone growth?", "Can you identify regions where immature bone is being replaced by more organized lamellar bone, indicating structural restoration?", "Is there visual evidence of cellular activity, such as bone matrix synthesis or resorption, contributing to restoration of bone integrity?", "Does the image suggest impaired function of nearby muscles or joints, such as restricted movement or joint stiffness?", "Can you see signs of new bone matrix being formed or damaged bone being resorbed, indicating coordinated bone turnover?", "Is there evidence of progressive mineralization or tissue remodeling that would restore mechanical strength to the bone?", "Does the image suggest the influence of regulatory mechanisms, such as growth factors or cytokines, in the healing process?", "Can you identify features consistent with immobilization, such as maintained bone alignment or restricted movement at the injury site?", "Is there visual indication of nutrient or oxygen delivery supporting tissue repair in the area of bone injury?"]}, "no_questions": {"contexual_properties": [], "properties": ["Based on visible signs, can you estimate whether the severity of the condition might be mild, moderate, or severe?", "Can you identify features that might suggest the person is a newborn within the first week of life?", "Are there visual cues that the yellow discoloration is resolving, possibly within 1\u20134 weeks after treatment?"], "relational": ["Can you identify any features in the small intestine that might be related to bilirubin clearance?", "Does the image show any evidence of altered coloration in tissues such as the skin or sclera?", "Are there visible abnormalities in the portal vein or cystic duct that could be associated with impaired bilirubin excretion?"], "contexual_behavior": [], "functions": ["Is there evidence of impaired digestion or nutrient absorption, such as signs of malnutrition or wasting?", "Does the image show features that could indicate impaired metabolism or accumulation of bile pigments in the body?", "Does the image suggest impaired detoxification processes, possibly due to hepatic overload?"]}}, "thecoma": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a mass present that measures between 5 and 10 centimeters in diameter?", "Can you identify a structure that appears round or oval in shape?", "Does the image show a mass with a yellow to yellow-white coloration?", "Is there a solid lesion with a firm consistency visible?", "Can you see a structure that appears to have high lipid content, as suggested by its color?", "Is there evidence of moderate to abundant collagen forming part of the stromal matrix in any mass present?", "Does the image show a lesion with low vascularity?", "Can you identify a mass that appears to have a slow growth rate based on its features?", "Is there a structure that seems to have moderate to high stromal cell density?", "Does any mass appear to have a low nuclear-to-cytoplasmic ratio, with abundant cytoplasm in its cells?", "Is there a lesion where calcifications are rare or absent?", "Can you see a mass with moderate water content suggested by its appearance?", "Does the image show a lesion with minimal or absent cellular atypia?", "Is there a structure where the mitotic activity appears very low, with less than 1 mitosis per high power field?", "Can you identify a mass that might express markers such as inhibin, calretinin, or vimentin?", "Does the extracellular matrix of any lesion appear to be composed mainly of collagen fibers and lipid-rich stroma?", "Is there a mass that could be associated with elevated estrogen production based on its features?"], "relational": ["Does the image show a structure associated with the reproductive system?", "Is there a mass containing stromal or connective tissue visible?", "Can you identify a lesion adjacent to the ovarian cortex or follicles?", "Does the image reveal a structure arising from the ovarian stroma or medulla?", "Is there a mass located within the pelvic cavity?", "Can you see evidence of blood vessels such as the ovarian artery or vein supplying a lesion?", "Is there a structure interacting with ovarian follicles, corpus luteum, or the surface epithelium?", "Does the image contain cells resembling theca cells or spindle-shaped stromal cells?", "Can you identify supporting fibrous stroma or vascular connective tissue surrounding a mass within the ovary?"], "contexual_behavior": ["Is there a structure in the image that could be responsible for increased estrogen production, particularly in individuals of reproductive age?", "Can you identify an object whose hormone secretion appears reduced in postmenopausal individuals?", "Does the image show a feature that might impair ovarian function during menopause by disrupting hormone balance?", "Is there evidence of a structure whose growth rate could be influenced by elevated gonadotropin levels or hormone therapy?", "Can you see an area where sex steroid production might be diminished due to cellular degeneration or insufficient theca cell function?", "Is there a region that could display increased metabolic activity during pregnancy as a result of elevated circulating hormones?", "Does the image contain a structure whose functional activity might be decreased following chemotherapy?", "Is there an object that could contribute to abnormal uterine bleeding by stimulating the endometrial lining with excess estrogen?", "Can you identify a structure whose hormone production may be altered in the presence of other ovarian tumors due to local paracrine signaling?", "Is there evidence of impaired steroidogenesis in an aging individual, possibly due to reduced enzymatic activity or cellular senescence?", "Does the image show a structure that could play a role in endometrial stimulation through high levels of estrogen secretion?", "Can you see a region whose functional impact might be reduced after surgical removal or debulking of tumor tissue?", "Is there a structure that could alter its biological behavior in response to metabolic stress, such as hypoxia or nutrient deprivation?", "Does the image contain an object whose estrogenic activity might lead to endometrial hyperplasia under prolonged unopposed estrogen exposure?", "Can you identify a feature whose function may change during recurrence after initial treatment, possibly due to genetic alterations or changes in the tumor microenvironment?"], "functions": ["Does the image show an ovarian mass that could be involved in hormone production?", "Is there a structure present that might be classified as an ovarian neoplasm?", "Can you identify a lesion that could be responsible for increased steroid hormone secretion, especially estrogen?", "Is there evidence of a tumor that may cause estrogen overproduction?", "Does the image contain a mass that could disrupt normal ovarian function or alter the ovarian environment?", "Can you see a structure that might be linked to hormonal imbalance or endocrine disruption?", "Is there a lesion that could regulate biological processes such as endometrial proliferation or menstrual cycle modulation?", "Does the image suggest the presence of a mass that could cause menstrual irregularities or abnormal uterine bleeding?", "Can you identify features consistent with endometrial hyperplasia or thickening, possibly due to increased estrogen levels?", "Is there a structure that might suppress other reproductive hormones by elevating estrogen?", "Does the image show a mass that could influence ovulation, fertility, or endometrial receptivity?", "Can you see evidence of stromal proliferation or compression of normal ovarian tissue adjacent to a mass?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure through which the hypoglossal nerve (cranial nerve XII) could pass?", "Is there a bone adjacent to the occipital lobe or cerebellum of the brain?", "Does the image show a component of the cranium that is positioned near the posterior cranial fossa?"], "contexual_behavior": ["Can you see any abnormalities in the enclosure of the posterior cranial fossa that might indicate developmental disorders affecting bone formation?", "Is there evidence of altered articulation with the cervical spine that might suggest surgical intervention affecting head movement support?", "Can you observe features of a cranial bone where increased porosity or decreased mass, possibly due to aging, could reduce its ability to absorb impact forces?"], "functions": ["Can you identify an opening at the base of the skull that allows the spinal cord to pass through?", "Is there a structure enclosing the foramen magnum?", "Is there evidence of an articulation that allows for nodding movements of the head?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Can you observe any enlargement of a lesion or expansion of an affected region outward from an initial site?", "Is there evidence of tissue hardening, such as areas that appear more firm or fibrotic compared to surrounding tissue?", "Does the image show evidence of cells spreading beyond their original boundaries into neighboring tissues?"], "properties": ["Is there an area where the density of abnormal cells per square millimeter appears increased compared to surrounding tissue?", "Is there a region in the image where the spatial extent of abnormal cell spread could be measured in square millimeters or centimeters?", "Can you identify a region where the percentage of affected tissue could be calculated as a proportion of the total area?"], "relational": ["Does the image show any disruption or penetration of anatomical boundaries such as tissue interfaces or organ capsules?", "Is there evidence of matrix metalloproteinase activity affecting the extracellular matrix?", "Is there visual indication of tissue destruction or local extension into surrounding structures?"], "contexual_behavior": [], "functions": ["Can you identify features suggesting the spread of pathogens through breached physical barriers?", "Does the image display signs of extracellular matrix breakdown or disrupted cellular architecture?", "Is there visual indication of adhesion or motility by microorganisms within the tissue?"]}}, "head": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with an ovoid or ellipsoid shape?", "Can you identify an object whose size could be approximately 22 cm in length and 17 cm in width in adults?", "Is there a structure present that might weigh around 4.5 to 5 kg in an adult?", "Can you see something with a circumference likely between 54 and 58 cm?", "Does the image contain an object with an estimated volume of about 1.3 to 1.5 liters?", "Is there a visible area where the skin color ranges from pale to dark brown depending on pigmentation?", "Can you identify a region where the bone density could be around 1.5 to 2.0 g/cm\u00b3?", "Is there a structure that might contain about 70% water by weight?", "Can you see an area where fat content could account for 10% to 15% of total weight?", "Does the image show a region where the scalp thickness is likely between 5 and 7 mm?", "Is there a structure composed of bone, muscle, skin, nervous tissue, connective tissue, and adipose tissue?", "Can you identify an area where the temperature would be approximately 36.5 to 37.5\u00b0C?", "Does the image show a region with dense hair, possibly 200 to 300 hairs per cm\u00b2?", "Is there a structure that could contain minerals such as calcium, phosphorus, and magnesium in its bony component?", "Can you see an area where the skin pH might be between 4.5 and 5.5?", "Is there a structure that could be made up of 22 bones in an adult?", "Can you identify a region with high oxygen consumption, likely due to brain metabolism?", "Does the image show an area with a high concentration of sensory receptors, especially in the lips or tongue?", "Is there a structure that receives significant blood flow, approximately 750 ml/min?", "Can you see a region where the proportion of gray to white matter might be about 1.3:1?"], "relational": ["Does the image show a region containing components of the nervous system?", "Is there a structure present that includes elements of the musculoskeletal system?", "Can you identify an area that contains organs of the sensory system?", "Does the image include any part of the respiratory or digestive systems within a single region?", "Are there visible bones such as the cranium, mandible, or maxilla?", "Can you see features corresponding to the zygomatic, nasal, or temporal bones?", "Is there a region that includes the occipital, parietal, or frontal bones?", "Does the image show a compartment that could contain the brain?", "Are there visible structures corresponding to the eyes, ears, or nose?", "Can you identify an area that might contain the tongue or salivary glands?", "Is there a region that could be classified as the cranial cavity, facial region, or oral cavity?", "Does the image show an area that could be the nasal or orbital cavity?", "Are there muscles present such as the masseter, temporalis, or frontalis?", "Can you see features corresponding to the orbicularis oculi, orbicularis oris, or buccinator muscles?", "Is there evidence of nerves such as cranial nerves, trigeminal nerve, or facial nerve passing through this region?", "Does the image show structures that could be innervated by the optic, olfactory, glossopharyngeal, or vagus nerves?", "Are there visible blood vessels such as the carotid arteries, vertebral arteries, or jugular veins?", "Can you identify arteries like the facial artery or superficial temporal artery in the region?", "Is there a connection to the neck via structures such as the atlanto-occipital joint or foramen magnum?", "Does the image show features that could be associated with cervical vertebrae or neck muscles?", "Are there sensory organs such as the eyes, ears, nose, or tongue present in the region?", "Can you see cavities such as the cranial cavity, nasal cavity, oral cavity, or orbital cavity?", "Is there evidence of the middle ear cavity or paranasal sinuses in the image?"], "contexual_behavior": ["Does the image show a structure that would exhibit reduced sensory processing during sleep in the NREM stages?", "Is there evidence of impaired coordination that could result from disrupted neural pathways after a traumatic injury?", "Can you identify a region where increased blood flow might occur during cognitive activity to meet metabolic demands?", "Does the image contain a structure that could lose its ability to regulate temperature in the event of heatstroke due to hypothalamic dysfunction?", "Is there a feature that could experience altered pain perception during a migraine as a result of trigeminovascular pathway sensitization?", "Can you see an area where neural activity would decrease under anesthesia due to suppressed central nervous system signaling?", "Is there a structure that might fail to maintain balance after vestibular dysfunction involving the inner ear or brainstem pathways?", "Does the image show a region where intracranial pressure could increase during infection as inflammation and edema develop?", "Is there a part that could demonstrate impaired speech production after a stroke affecting language centers?", "Can you identify an area that would show reduced oxygen supply in hypoxic conditions when arterial oxygen levels fall?", "Is there a structure that might alter its sensory integration during sensory overload due to overstimulated neural circuits?", "Does the image show a region that could experience diminished reflex responses as neuronal degeneration progresses in neurodegenerative disease?", "Is there a part that would increase metabolic demand during mental stress as neuronal activity and glucose consumption rise?", "Can you see evidence of impaired eye movement coordination that could result from disruption of oculomotor pathways after concussion?", "Is there a region that could show impaired thermoregulation in hypothalamic disorders when temperature control centers are affected?"], "functions": ["Does the image show a structure that houses multiple sensory organs such as those for vision, hearing, smell, taste, or touch?", "Can you identify a region that protects a major neural organ within a bony cavity?", "Is there a part visible that enables communication through speech or facial expressions?", "Does the image contain structures responsible for sensory integration, such as eyes, ears, nose, tongue, or skin?", "Can you see evidence of a bony structure that safeguards neural tissue?", "Is there a region that facilitates feeding and swallowing by coordinating the mouth, jaws, tongue, or pharynx?", "Does the image include features associated with balance and orientation, such as the vestibular system or inner ear?", "Can you identify an area that assists with breathing or olfaction by containing a nasal cavity or respiratory passages?", "Is there a structure that enables facial expression via the action of muscles controlled by cranial nerves?", "Does the image show components involved in hearing, such as the auricle, tympanic membrane, or cochlea?", "Can you see organs responsible for vision and eye movement, including extraocular muscles or the optic nerve?", "Is there evidence of taste sensation through the presence of a tongue or palate?", "Does the image reveal structures that contribute to speech production, such as the larynx, vocal cords, tongue, lips, or jaw?"]}, "no_questions": {"contexual_properties": ["Does the image show a tube that is in close contact with an ovary on the other side of the field?", "Can you identify a tube-like feature that is adherent to an adjacent ovarian structure across from it?", "Is there a tubular structure in the image that appears to be attached to an ovary located on the opposite side?"], "properties": ["Can you identify a tube-like feature that is visually adherent to an adjacent ovarian structure on the contralateral side?", "Is there a tubular structure in the image that appears to be attached to an ovary located on the opposite side?", "Does the image show a tube in close association with an ovary that is positioned on the other side of the body or field of view?"], "relational": ["Can you identify a tube-like structure in the adnexal or pelvic region that is connected to both the uterus and the ovary?", "Does the image contain a structure supported by the broad ligament, mesosalpinx, or serosal layer?", "Does the image show a structure that is part of the female reproductive system and is physically attached to an ovary?"], "contexual_behavior": ["Can you see any indication of tubal obstruction or microenvironment disruption that could interfere with fertilization?", "Is there a loss of normal communication between a tubular structure and the uterine cavity, possibly due to occlusion or severe adhesion?", "Does the image suggest decreased debris clearance or pathogen removal in a tube near the ovary, possibly from impaired ciliary function?"], "functions": ["Does the image show a structure adjacent to an ovary that is involved in transporting eggs?", "Is there a tube present that supplies nutrients and maintains a microenvironment for an embryo in transit?", "Can you identify a tube-like structure that supports fertilization by providing a site for sperm and egg interaction?"]}}, "scalp": {"yes_questions": {"contexual_properties": ["Is there a region that appears swollen, possibly due to trauma or infection?", "Can you observe any areas with discoloration suggestive of bruising or vascular lesions?", "Does the image show thickened folds or ridges that could indicate a chronic inflammatory skin disorder?", "Are there regions that appear thinner, possibly due to aging or atrophy?", "Can you identify any scaling or flaking that might be associated with seborrheic dermatitis or a fungal infection?", "Is there evidence of excessive oiliness, such as a shiny surface, that could be due to overactive sebaceous glands?", "Do you see any dry or rough patches that may result from eczema or environmental factors?", "Is there a visible loss of elasticity, such as sagging or wrinkling, that could be related to aging or connective tissue disorders?", "Are there any lesions present that might suggest infection, autoimmune disease, or neoplastic processes?", "Can you detect increased redness that could indicate inflammation or sunburn?", "Is there a presence of crusts, possibly resulting from impetigo or scratching?", "Do any areas appear tender or inflamed, suggesting infection or trauma?", "Can you see patches where hair is missing, which might be due to alopecia or a fungal infection?", "Is there visible accumulation of sebum, possibly indicating seborrheic dermatitis or hormonal changes?", "Are there regions that seem more sensitive or irritated, potentially due to contact dermatitis or chemical exposure?", "Do you observe areas of hyperpigmentation that could follow inflammation or chronic dermatitis?", "Are there patches of lighter color that might indicate hypopigmentation from vitiligo or post-inflammatory changes?", "Can you identify flaky regions that could be consistent with dandruff or psoriasis?", "Is there evidence of thickened plaques that might suggest chronic psoriasis or discoid lupus erythematosus?", "Do you see increased vascularity, such as prominent blood vessels, possibly due to chronic inflammation or healing?"], "properties": ["Is there a region in the image that appears to have a thickness between 5 and 7 millimeters?", "Can you identify an area with a surface area roughly between 500 and 600 square centimeters?", "Does the image show a region with a pale or light pink coloration, depending on skin pigmentation?", "Is there a structure that could weigh approximately 600 to 700 grams in adults?", "Can you see an area that appears smooth and pliable due to its layered structure?", "Does the image contain tissue likely composed of keratinocytes, melanocytes, fibroblasts, and hair follicle cells?", "Is there a region where the density of hair follicles seems to be about 100 to 150 follicles per square centimeter?", "Can you identify an area where the acidity might be within a pH range of 4.5 to 5.5?", "Does the image show a structure that could have a water content of approximately 60 to 70 percent by weight?", "Is there a region where the lipid content might be about 10 to 15 percent of the outermost layer by weight?", "Can you see an area with a high density of sebaceous glands, around 80 to 100 glands per square centimeter?", "Does the image show a region that could have a temperature between 33 and 35 degrees Celsius?", "Is there a structure where the melanin concentration appears lower than that of facial skin, but variable with ethnicity?", "Can you identify an area where the collagen content in the dermis is approximately 70 to 80 percent of its dry weight?", "Does the image show a region with a blood flow rate of about 50 to 70 milliliters per minute per 100 grams of tissue?", "Is there an area with a sweat gland density of about 200 to 400 glands per square centimeter?", "Can you see a region where the skin shows moderate elasticity, allowing for movement and stretching over the underlying bone?", "Does the image show an area where the moisture level in the outermost layer is maintained at around 20 to 30 percent?", "Is there a region where the cell turnover rate in the outer skin layer is approximately 28 to 30 days?", "Can you identify an area where the thickness of the outermost skin layer is about 0.05 to 0.1 millimeters?"], "relational": ["Does the image show a region located on the head?", "Can you identify an area composed of multiple layers, including skin and connective tissue?", "Is there a structure that overlies the frontal, parietal, temporal, or occipital bones?", "Does the image contain tissue associated with both the integumentary and nervous systems?", "Can you see an area that might receive blood supply from branches such as the superficial temporal or occipital arteries?", "Is there a region likely innervated by branches of the trigeminal or cervical nerves?", "Does the image show a connection between the occipitofrontalis muscle and a broad aponeurotic layer?", "Can you identify a region bordered by the face, nape of the neck, and temporal areas?", "Is there a visible area containing layers such as epidermis, dermis, subcutaneous tissue, and periosteum?", "Does the image include a soft tissue covering that provides protection for the cranial bones?"], "contexual_behavior": ["Is there evidence of a structure that enhances its protective barrier in response to increased microbial exposure or minor injury?", "Can you identify an area where thermoregulation might be impaired due to severe burns or extensive scarring?", "Does the image show signs of heightened sensory response, such as inflammation that could lead to increased nerve sensitivity?", "Is there a region where sebum production appears abnormal, possibly due to psychological or physiological stress?", "Can you observe delayed healing in an area with poor vascular supply, infection, or signs of systemic disease?", "Does the image reveal features consistent with dermatological diseases like psoriasis, eczema, or seborrheic dermatitis, indicating barrier dysfunction?", "Is there visual evidence of increased sweating in response to physical activity?", "Can you identify signs of compromised immune defense, such as chronic disease or immunosuppression?", "Does the image show reduced blood flow or pallor in response to cold exposure, suggesting vasoconstriction?", "Is there an area where hair growth appears reduced, possibly due to hormonal changes such as menopause or thyroid disorders?", "Can you see signs of exaggerated response to allergens, as might occur in atopic or allergic contact dermatitis?", "Does the structure show features of aging, such as thinning skin or reduced regenerative capacity, indicating declined protection?", "Is there evidence of an increased inflammatory response, such as immune cell recruitment or cytokine production, in the presence of infection?", "Can you identify regions with reduced sensory perception, as might be seen in neuropathic disorders or nerve injury?", "Does the image suggest impaired moisture retention, such as dryness or increased transepidermal water loss, possibly due to dehydration?"], "functions": ["Is there a structure visible that provides protection for the head?", "Can you identify a region that supports hair growth by nourishing hair follicles?", "Does the image show a multilayered area that acts as a physical barrier and cushions the skull?", "Is there evidence of a structure that helps regulate temperature through blood flow or sweat glands?", "Can you see an area that might facilitate sensory perception, such as detecting touch or temperature?", "Is there a region that acts as a barrier against infection, possibly through an intact epidermis or secretion of antimicrobial substances?", "Does the image display features consistent with shock absorption, such as connective or fatty tissue layers?", "Can you identify a surface that maintains skin hydration by producing sebum or retaining moisture?", "Is there a region that could participate in wound healing by supporting tissue repair or local immune responses?", "Does the image show an area involved in immune defense, such as through resident immune cells or protective secretions?"]}, "no_questions": {"contexual_properties": [], "properties": ["Are there cells present that could account for a normal count of 1,500 to 8,000 per microliter in human blood?", "Is it possible to observe cells with a density close to 1.08 grams per milliliter?", "Are there cells present that contain granules within their cytoplasm?"], "relational": ["Does the image include structures produced in the bone marrow?", "Is there a structure associated with blood components such as plasma, red blood cells, or platelets?", "Are there cells migrating toward damaged or infected tissue in the image?"], "contexual_behavior": [], "functions": ["Can you see cells that might be releasing growth factors to promote tissue repair?", "Does the image contain cells that perform phagocytosis and lysosomal degradation of pathogens or debris?", "Can you observe any signs of tissue damage that could be caused by the release of proteolytic enzymes or reactive oxygen species?"]}}, "endocrine": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure that produces hormones such as insulin or cortisol?", "Can you identify an object that might secrete thyroxine, estrogen, or testosterone?", "Is there a structure that could be responsible for releasing growth hormone or adrenaline?", "Does the image contain a gland with a lobular or clustered appearance?", "Can you see a structure that appears highly vascularized, suggesting rapid hormone release into the bloodstream?", "Is there an object whose size could range from a few millimeters to several centimeters?", "Can you identify a structure that might weigh less than 1 gram up to about 20 grams?", "Does the image show tissue composed of specialized secretory cells such as chromaffin or follicular cells?", "Is there a structure that appears pale pink or reddish-brown in color?", "Can you see a gland with a soft, friable texture?", "Is there an object with an oval, round, or irregular shape?", "Does the image show a structure that might have a high water content, around 70\u201380% by weight?", "Can you identify tissue that could have moderate lipid content, approximately 5\u201315% by weight?", "Is there a structure that might contain about 10\u201320% protein by weight?", "Can you see a gland that likely has low carbohydrate content, less than 5% by weight?", "Does the image show tissue that could have trace amounts of minerals such as calcium, potassium, or sodium?", "Is there an object that might contain two to five distinct cell types?", "Can you identify a structure that would function optimally at a temperature of 36\u201337\u00b0C?", "Does the image show a gland that would have a slightly alkaline pH, around 7.2 to 7.4?", "Is there a structure where the concentration of secreted molecules could be in the nanomolar to picomolar range?"], "relational": ["Does the image contain a gland located in the brain, neck, abdomen, pelvis, or thorax?", "Can you identify a structure that is ductless and releases substances directly into the blood?", "Is there an organ that could be part of the reproductive, metabolic, skeletal, or cardiovascular system due to hormonal influence?", "Does the image show a structure that could be the pituitary gland, thyroid gland, adrenal gland, pancreas, pineal gland, parathyroid gland, ovaries, or testes?", "Can you see a tissue that might interact with blood or nervous tissue as part of its function?", "Is there a structure that could be supplied by the hypophyseal portal system, thyroid arteries, adrenal arteries, or pancreatic blood vessels?", "Does the image contain a region where neuroendocrine integration or hypothalamic-pituitary axis activity might occur?", "Can you identify a structure that could contain endocrine cells, chromaffin cells, follicular cells, or islet cells?", "Is there an organ that is structurally linked to the hypothalamus, pituitary gland, thyroid gland, adrenal glands, or pancreas?", "Does the image show a gland that influences target organs through feedback loops?"], "contexual_behavior": [], "functions": ["Does the image show any structures responsible for hormone secretion?", "Can you identify a feature involved in regulating metabolism or maintaining physiological balance?", "Is there evidence of a gland or tissue participating in negative feedback or hormonal control?", "Does the image contain a structure that could release hormones such as insulin, glucagon, or thyroid hormones?", "Can you see an organ that might control growth or development through hormone secretion?", "Is there a visible feature associated with the stress response, such as the adrenal glands?", "Does the image include a structure involved in sexual development or reproductive cycles?", "Can you identify a feature that might help maintain homeostasis by adjusting physiological processes?", "Is there a structure that could regulate blood sugar through the production of insulin or glucagon?", "Does the image show any features that could influence mood or behavior via hormone action on the brain?", "Can you see evidence of coordination between hormone-producing structures and other body systems such as the nervous or digestive system?", "Is there a structure that might help maintain electrolyte balance by regulating sodium, potassium, or water levels?", "Does the image include a feature that could regulate blood pressure through hormonal mechanisms?", "Can you identify a structure that might adjust hormone secretion in response to environmental changes like light or temperature?", "Is there a feature involved in synchronizing physiological processes with the day-night cycle?", "Does the image show a structure that could modulate immune function through hormone release?"]}, "no_questions": {"contexual_properties": ["Does the image show evidence of abnormal tissue growth on the outer surfaces of reproductive organs such as the uterus or ovaries?", "Can you identify any lesions or nodules present on the serosal surfaces of pelvic organs?", "Is there visual indication of metastatic spread involving the lining of the abdominal cavity and affecting female reproductive structures?"], "properties": ["Does the image show abnormal tissue growths on the outer surfaces of pelvic reproductive organs?", "Is there evidence of pathological implants on the outer surface of the ovaries?", "Are there visual signs of disease affecting both the uterus and ovaries at their outermost layers?"], "relational": ["Is there evidence of implants on the visceral peritoneum or subserosal connective tissue in the pelvic cavity?", "Can you identify any lesions or nodules involving the serosal surfaces of structures such as the uterus or ovaries?", "Does the image reveal changes on the uterine or ovarian surfaces consistent with involvement of the pelvic peritoneum?"], "contexual_behavior": ["Is there visual indication of metastatic deposits on the peritoneal surfaces adjacent to female reproductive structures?", "Does the image show evidence of abnormal growths on the outer surfaces of reproductive organs such as the uterus or ovaries?", "Does the image reveal any irregularities or masses on the surfaces of organs within the pelvic cavity?"], "functions": ["Does the image suggest impaired organ function, such as changes in the appearance of the uterus or ovaries that could indicate dysfunction?", "Can you see any features that could indicate tissue damage, fibrosis, or impaired tissue repair in the uterus or ovaries?", "Can you identify any structural disruption or abnormal tissue architecture involving the uterus or ovaries?"]}}, "view of head": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling that could suggest trauma, infection, or an allergic reaction?", "Can you identify any areas of discoloration that might indicate bruising, cyanosis, or jaundice?", "Does the image show asymmetry that could be related to a congenital anomaly, tumor, or previous injury?", "Is there a noticeable abnormality in size that could be consistent with macrocephaly, microcephaly, or hydrocephalus?", "Can you see any deformities that might be associated with craniofacial syndromes, trauma, or developmental disorders?", "Is there visible bruising that could result from blunt force, a fall, or a coagulopathy?", "Does the image reveal changes in contour that might be due to a mass, edema, or a bone abnormality?", "Are there any visible masses or lumps that could represent a cyst, tumor, or abscess?", "Can you observe any skin changes that might be due to a dermatological condition, infection, or inflammation?", "Is there an area with abnormal texture that could be explained by scarring, edema, or a dermatological disorder?", "Does the image show evidence of hair loss that might be related to alopecia, a fungal infection, or an autoimmune disease?", "Is there increased redness that could suggest cellulitis, erythema, or an allergic reaction?", "Can you see pallor that might be associated with anemia, shock, or vascular insufficiency?", "Are there abnormal surface features such as lesions, ulcers, or congenital malformations present?", "Is there visible edema that could be due to an allergic reaction, infection, or heart failure?"], "properties": ["Does the image display a region with an oval or rounded shape that matches the typical contours of the human head?", "Can you identify anatomical landmarks such as the skull, orbits, nasal cavity, mandible, or cranial sutures in the image?", "Is the orientation of the image consistent with axial, coronal, or sagittal planes commonly used in medical imaging?", "Does the image appear to be captured in the axial plane, as is standard for this type of view?", "Is the spatial resolution of the image sufficient to distinguish features at the millimeter scale, typically between 0.3 mm and 1 mm per pixel?", "Can you observe differentiation between soft tissue, bone, and air spaces, indicating appropriate contrast levels in the image?", "Is the brightness of the image optimized to clearly visualize anatomical structures?", "Does the field of view encompass the entire cranium and facial bones, covering an area approximately 18\u201325 centimeters in size?", "Is the image presented in grayscale, or does it use color representation as seen in some imaging modalities?", "Does the pixel density appear to be around 1\u20132 pixels per millimeter, providing adequate spatial sampling?", "Is the aspect ratio of the image close to 1:1, suggesting a square format?", "Does the scale or magnification of the image correspond to life-size or a 1:1 anatomical scale?", "If the image is cross-sectional, is the slice thickness between 1 and 5 millimeters as is typical for this type of view?", "Does the anatomical coverage in the image include the entire skull, facial bones, and soft tissues of the head?", "Is the image size within the typical range of 512x512 to 1024x1024 pixels?"], "relational": ["Does the image display a region that includes both cranial and facial areas?", "Can you identify bones such as the frontal, parietal, or zygomatic in the image?", "Is there evidence of structures like the maxilla or mandible present?", "Does the image contain organs such as the brain, eyes, or oral cavity?", "Are sensory structures like the ears or nose visible?", "Can you see muscles such as the masseter or temporalis in the depicted region?", "Is there a visible feature corresponding to the orbicularis oculi or orbicularis oris?", "Does the image show blood vessels such as the superficial temporal artery or facial artery?", "Can you identify any veins or arteries like the external jugular vein or internal carotid artery?", "Are nerves such as the facial or trigeminal nerve represented in the image?", "Is there a visible indication of the optic or olfactory nerve?", "Does the image include cavities like the cranial, nasal, or orbital cavity?", "Can you see the oral cavity or any of its boundaries?", "Are tissues such as bone, muscle, or nervous tissue observable in the depicted area?", "Is there evidence of connective or epithelial tissue in the region shown?", "Does the image contain anatomical landmarks such as the hairline, chin, or jaw angle?", "Can you identify the zygomatic arch, supraorbital margin, or mastoid process in the image?", "Is there a region defined by both the cranial cavity and the facial region present?", "Does the image show taste buds or structures associated with taste sensation?"], "contexual_behavior": ["Does the image show a situation where sensory input might be reduced due to visual impairment such as cataracts or retinal disease?", "Is there evidence of altered head orientation that could be related to balance disturbances like vertigo or vestibular dysfunction?", "Can you observe a change in the field of vision that might result from head rotation or eye movement?", "Does the image suggest a restricted field of view that could be associated with neurological disorders such as stroke or multiple sclerosis?", "Is there an indication that head position is being adjusted to compensate for vestibular dysfunction and stabilize gaze?", "Can you see signs of gaze maintenance during rapid movement, possibly reflecting the vestibulo-ocular reflex?", "Does the image include features that might indicate impaired vision following traumatic injury to the brain, eyes, or cranial nerves?", "Is there visual evidence of adaptation to low-light conditions, such as increased retinal sensitivity or pupil dilation?", "Can you detect a narrowed field of view that might be associated with migraine aura or transient visual disturbances?", "Does the image suggest realignment of gaze and head position to maintain equilibrium during motion sickness?", "Is there a sign of altered awareness of one side of space, possibly indicating spatial neglect syndrome?", "Can you observe changes in head or eye direction that might occur during visual field testing?", "Is there evidence of image instability that could be due to involuntary eye movements, such as nystagmus?", "Does the image suggest an expanded field of view or increased visual attention, as might occur during heightened alertness?", "Can you see limitations in the field of vision that could result from swelling or inflammation affecting the eyes, eyelids, or surrounding tissues?"], "functions": ["Can you identify any anatomical structures in the head region that would be relevant for clinical evaluation?", "Does the image provide enough visual information to assess for pathological changes in the head?", "Is there evidence of cranial nerve function or abnormal head posture observable in the image?", "Can you detect any abnormal movements that might indicate a neurological condition?", "Does the image reveal any signs of cranial trauma, such as deformities, lacerations, or hematomas?", "Is there visible asymmetry when comparing bilateral facial features?", "Can you observe any fractures, depressions, or abnormal contours in the skull?", "Does the image allow for identification of cranial or facial anatomical landmarks useful for surgical planning?", "Is there any indication of swelling, changes in mass size, or deformity that could be monitored over time?", "Can you visually inspect the scalp, face, jaw, or cervical regions for abnormalities?", "Are there any abnormal contours, asymmetry, or visible lumps suggesting soft tissue swelling or masses?", "Does the image enable rapid identification of external injuries, bleeding, or deformities in the head region?"]}, "no_questions": {"contexual_properties": ["Are there visible indications of congenital anomalies in two infants, particularly if they appear monozygotic?", "Does the image suggest an increased risk of low birth weight in two infants, particularly after 32 weeks of gestation?", "Is there a difference in crown-rump length between two fetuses that becomes more pronounced in the second or third trimester?"], "properties": ["Are there two infants whose Apgar scores at 5 minutes might fall within the 7 to 9 range?", "Are there two newborns present whose combined birth weights appear lower than that of a typical singleton?", "Is there evidence of two neonates with hemoglobin levels likely within the 14 to 20 g/dL range?"], "relational": ["Is there evidence of the maternal cardiovascular, endocrine, or reproductive systems supporting more than one developing fetus?", "Does the image indicate the presence of diamniotic or monoamniotic sacs around the fetuses?", "Can you observe vascular connections between placental regions, such as arterio-arterial or veno-venous anastomoses?"], "contexual_behavior": ["Is there evidence of two newborns whose neurological development could have been affected by perinatal hypoxia during birth or the immediate neonatal period?", "Are there two newborns who might have experienced changes in oxygen delivery during a complicated or prolonged labor?", "Can you identify two infants who may have shared nutrients differently during the second or third trimester of pregnancy?"], "functions": ["Does the image show more than one fetus sharing a uterine environment?", "Are there signs of adverse birth outcomes, such as preterm delivery or the need for neonatal intensive care, involving two newborns?", "Do you notice features consistent with growth restriction or differences in size between two co-developing individuals?"]}}, "muscle atrophy": {"yes_questions": {"contexual_properties": ["Does the image show a region where muscle mass appears reduced compared to surrounding areas?", "Can you identify a muscle that appears visibly thinner than normal?", "Is there evidence of increased fat or connective tissue within a muscle structure?", "Does the image reveal a muscle with decreased cross-sectional area or volume?", "Can you see signs of muscle weakness, such as reduced muscle bulk or loss of tone?", "Is there a muscle that appears paler or has a different color, suggesting replacement by fatty or connective tissue?", "Does the image show muscle fibers that seem shrunken or diminished in size?", "Is there a visible change in muscle texture, such as increased fibrous appearance or loss of normal striations?", "Can you observe a muscle with decreased density, possibly due to loss of contractile proteins?", "Is there evidence of muscle wasting that could be associated with chronic disease, prolonged inactivity, or aging?", "Does the image display a muscle with signs of fibrosis or increased connective tissue content?", "Can you identify a muscle that appears to have lost volume due to replacement by non-muscle tissue?", "Is there a region where muscle tone seems reduced, possibly due to lack of neural stimulation?", "Does the image suggest muscle wasting that could be accelerated by systemic illness or corticosteroid use?", "Can you see any muscle changes that might indicate malnutrition, immobilization, or disuse?"], "properties": ["Can you identify a region where the mass of contractile tissue appears reduced by up to 20% compared to surrounding areas?", "Is there evidence of muscle fibers that appear thinner, with diameters decreased by as much as 30%?", "Does the image show tissue where the cross-sectional area of fibers is visibly reduced by up to 50%?", "Can you see a region where the density of muscle tissue appears lower, possibly due to increased fat content?", "Is there an area where the tissue appears paler or lighter in color than typical healthy muscle?", "Does any region show a softer or less firm texture compared to adjacent muscle tissue?", "Can you identify tissue that might have increased fat or connective tissue infiltration?", "Is there a visible indication of increased collagen or fibrotic tissue within the muscle?", "Does the image suggest a reduction in muscle strength, as might be inferred from decreased muscle bulk?", "Can you see evidence of reduced mitochondrial content, such as a loss of oxidative capacity in the tissue?", "Is there a region where muscle glycogen stores might be depleted, as suggested by changes in tissue appearance?", "Does the image show muscle tissue that could have decreased levels of muscle-specific enzymes like creatine kinase?", "Can you identify an area where the water content appears slightly reduced compared to normal muscle tissue?"], "relational": ["Does the image show a region where skeletal muscle tissue appears reduced or diminished?", "Can you identify any areas in the upper or lower limbs that display signs of decreased muscle mass?", "Is there evidence of changes in the arms or legs that could suggest involvement of the musculoskeletal system?", "Does the image reveal any alterations in structures such as tendons or bones adjacent to muscles?", "Can you observe any features that might indicate impaired neural input, such as changes near peripheral nerves or motor neurons?", "Are there visible differences in the hands or feet that could be associated with reduced muscle bulk?", "Does the image show connective tissue structures like endomysium or perimysium in association with thin or wasted muscles?", "Is there any indication of altered cellular components, such as reduced density of myofibrils or mitochondria, within muscle tissue?", "Can you see any changes in the relationship between muscles and nearby joints or ligaments?", "Does the image suggest involvement of neuromuscular junctions in areas where muscle tissue appears diminished?"], "contexual_behavior": [], "functions": ["Does the image show evidence of decreased muscle mass or impaired muscle function?", "Can you identify signs of reduced muscle strength or limited range of movement?", "Is there any indication of impaired mobility or increased risk of falls?", "Does the image suggest a reduction in basal metabolic rate or protein synthesis due to loss of muscle tissue?", "Can you observe features that might indicate lower overall energy expenditure?", "Is there visual evidence of reduced endurance or impaired ability to perform physical tasks?", "Does the image reveal postural weakness or signs of balance impairment?", "Can you see indications of diminished adaptation to exercise or increased fatigue?", "Is there any sign that recovery from injury or illness might be delayed or functional deficits prolonged?", "Does the image suggest impaired glucose uptake or decreased insulin sensitivity in muscle tissue?", "Can you observe decreased joint stability or muscle weakness supporting the joints?", "Is there any indication of impaired thermoregulation or reduced heat production?", "Does the image show features that might contribute to increased frailty or progression of chronic diseases?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a centrally located cell that appears round or oval in shape?", "Is there a cell in the center field with a nuclear-to-cytoplasmic ratio close to 1:1 or slightly higher?", "Does the nucleus of the central cell appear to be between 6 and 10 micrometers in diameter?"], "relational": ["Does the area surrounding the central prominent cell contain anatomical structures like blood vessels, connective tissue, or a basement membrane?", "Is the anatomical region containing the central prominent cell best described as cortex, medulla, or parenchyma?", "Can you determine if the central prominent cell is part of a broader system, such as the immune, circulatory, or digestive system, based on its context?"], "contexual_behavior": [], "functions": ["Is there evidence of a cell in the center that regulates apoptosis or modulates the local microenvironment?", "Does the image reveal a cell in the center field that appears to be involved in receptor-mediated signaling or paracrine communication?", "Is there a centrally located cell that appears to provide structural support to the surrounding tissue?"]}}, "view of head with scalp retracted to show fractures": {"yes_questions": {"contexual_properties": ["Does the image show an area of soft tissue swelling or localized inflammation overlying a cranial injury?", "Can you identify regions where the tissue color appears altered, such as bruising or ecchymosis, near a site of trauma?", "Is there visible evidence of increased bleeding or vascular injury in the soft tissue overlying a cranial fracture?", "Does the image display edematous tissue or fluid accumulation in the area surrounding a bone injury?", "Can you observe increased thickness of the soft tissue as a result of swelling or hematoma formation?", "Is there a collection of blood beneath the soft tissue, such as a hematoma, overlying a cranial defect?", "Does the exposed bone show signs of displacement or depression consistent with a skull fracture?", "Are there any lacerations or open wounds in the soft tissue that could be associated with underlying bone injury?", "Is the soft tissue retracted in a way that suggests reduced resistance due to connective tissue damage?", "Can you see evidence of depressed or comminuted fractures of the exposed bone after the soft tissue has been retracted?", "Does the surface of the soft tissue appear to have an abnormal texture, possibly due to swelling or tissue disruption?", "Is there an area of pallor or mottling in the tissue overlying a cranial injury, suggesting compromised blood flow?", "Can you identify changes in the composition of the soft tissue, such as infiltration by inflammatory cells or development of edema?", "Does the image suggest increased tenderness or nerve irritation in the tissue overlying a bone injury, as might be inferred from signs of inflammation?", "Is there visible separation between the soft tissue and the underlying bone, possibly due to displacement or severe fracture?"], "properties": ["Does the image show disruptions in the continuity of cranial bones that appear as linear or comminuted patterns?", "Can you identify any irregular, jagged, or branching lines on the exposed cranial surface?", "Is there a structure in the image that is white or off-white in color and appears to be bone?", "Can you visually estimate if the thickness of the exposed cranial bones falls within the range of 4 to 7 millimeters?", "Does the bone surface appear hard, smooth, and slightly porous?", "Are there between one and three distinct fracture lines visible on the cranial bones?", "Do any of the fracture lines appear to be less than 1 millimeter in width?", "Is the length of the largest visible fracture several centimeters or possibly up to 10 centimeters or more?", "Can you observe if the distance between adjacent fracture lines measures several millimeters to a few centimeters?", "Do any of the fractures seem to extend through the full thickness of the cranial bone, approximately 4 to 7 millimeters?", "Are the underlying tissues exposed in the image pink or red, suggesting vascularity?", "Is there evidence of moderate bleeding originating from the scalp or fracture sites?", "Can you distinguish both compact (cortical) bone and underlying cancellous (spongy) bone in the exposed area?", "Does the density of the visible cranial bone appear consistent with a value of approximately 1.5 to 2.0 grams per cubic centimeter?", "Is there a thin, pale, fibrous membrane closely adherent to the outer surface of the bone, consistent with the periosteum?"], "relational": ["Does the image display an area where the outermost soft tissue layers have been moved aside to reveal the calvaria?", "Can you identify the cranial vault with its underlying bony structures exposed?", "Are the frontal, parietal, temporal, or occipital bones visible in the image?", "Does the image show tissue layers such as the subcutaneous tissue or galea aponeurotica between the skin and the skull?", "Can you see connective tissues like the pericranium or galea aponeurotica present beneath the scalp?", "Are features such as cranial sutures or diploic spaces visible on the exposed skull surface?", "Does the image reveal the outer table of the skull?", "Can you identify any fractures, such as linear, depressed, or comminuted types, on the exposed cranial bones?", "Are there visible signs of injury to the parietal or temporal bones, which are commonly fractured in this region?", "Does the image show anatomical boundaries such as the superior nuchal line, supraorbital margin, temporal lines, or zygomatic arches?", "Can you see neurovascular structures like the superficial temporal artery, occipital artery, or branches of the trigeminal nerve exposed by the removal of the scalp?", "Is there evidence that the protective barrier normally provided by the scalp is absent, exposing the underlying cranial bones?"], "contexual_behavior": ["Does the image show a situation where the brain is more exposed due to loss of soft tissue and bone integrity?", "Is there evidence of increased risk for infection because protective barriers have been compromised?", "Can you identify a scenario where the cranial cavity is exposed, potentially affecting intracranial pressure?", "Does the image suggest impaired hemostatic function, such as visible bleeding from disrupted blood vessels?", "Is there a loss of the head's barrier function against environmental pathogens visible in the image?", "Can you see signs that local temperature regulation might be impaired due to loss of insulating tissue?", "Does the image indicate delayed healing or increased tissue damage that could slow the recovery process?", "Is there visual evidence suggesting a risk of cerebrospinal fluid leakage from disruption of the dura mater or cranial vault?", "Can you observe compromised structural support for facial muscles due to destabilized bone and connective tissue?", "Does the image show possible sensory alteration or nerve exposure resulting from underlying fractures?"], "functions": ["Does the image show a situation where fracture lines can be directly inspected and precisely localized?", "Can you identify areas where visualization of bone injury might help assess potential brain compromise or dural tears?", "Is there evidence of surgical access to cranial fractures, such as unobstructed exposure for debridement or stabilization?", "Does the image allow for assessment of the extent of bone injury and involvement of vital structures to inform treatment planning?", "Can you observe patterns in the exposed bone that could be used to predict complications or guide reconstruction?", "Is there visual access to injured vessels that would facilitate bleeding control or hemostasis?", "Does the exposure provide clear access for procedures like fracture fixation or bone grafting?", "Can you see features that would assist in evaluating possible damage to the dura mater or brain parenchyma?", "Is there an opportunity to assess the displacement or alignment of bone fragments for surgical repair?", "Does the image suggest that infection prevention measures, such as irrigation or removal of foreign material, could be performed before closure?"]}, "no_questions": {"contexual_properties": ["Is there a structure in the image that appears enlarged, possibly due to growth, inflammation, or tumor formation?", "Does the image show changes in density, such as increased calcification, fat infiltration, or fluid accumulation?", "Is there a region that appears fibrotic, possibly due to chronic inflammation, injury, or fibrotic disease?"], "properties": ["Can you see a structure whose lifespan could range from hours to years depending on its type?", "Can you see a structure where proteins might make up 10% to 20% of its mass?", "Is there an object that could contain about 70% water by weight?"], "relational": ["Can you identify any object for which the relationship to secondary structures cannot be described?", "Does the image show any area where anatomical boundaries cannot be defined without additional anatomical information?", "Does the image contain any structure whose anatomical context is ambiguous or cannot be determined?"], "contexual_behavior": ["Can you observe signs of impaired function in a structure that might have suffered injury or inflammation?", "Does the image show a system with accelerated activity, which could indicate activation during acute illness?", "Is there evidence in the image of a tissue whose main function appears impaired, possibly due to pathological changes?"], "functions": ["Can you identify structures that support organ-specific roles through specialized cellular functions?", "Can you see indications of cells sensing environmental changes or communicating with neighboring cells to maintain homeostasis?", "Is there visual evidence of cell proliferation or differentiation that would suggest regeneration or replacement of damaged tissue?"]}}, "massive fractures": {"yes_questions": {"contexual_properties": ["Is there evidence of bone fragments that are displaced from their normal position, suggesting a forceful injury?", "Can you observe significant swelling or edema at a site where bone continuity appears disrupted?", "Does the image show abnormal angulation or malalignment of a bone, indicating disrupted alignment of bone fragments?", "Is there a region where the bone appears to have lost its structural integrity, with possible instability or loss of support?", "Can you identify a visible deformity or distortion in the contour of a limb, possibly due to displaced bone fragments?", "Is there visual evidence of increased bleeding or hemorrhage around a disrupted bone area, such as pooling of blood or vascular injury?", "Do you see soft tissue swelling or signs of an inflammatory response adjacent to a disrupted bone structure?", "Is there a noticeable shortening of a limb or bone segment, possibly due to overlapping bone fragments?", "Can you observe changes in skin color, such as bruising or ecchymosis, overlying a region of bone disruption?", "Is there a large hematoma or collection of blood visible in the soft tissues near a disrupted bone?", "Does the image show exposed bone ends protruding through the skin, indicating an open injury?", "Can you detect abnormal mobility or pathological movement at a site where bone continuity is lost?", "Is there evidence of a bone shattered into multiple pieces, suggesting comminution from high-energy impact?", "Do you notice increased local temperature or redness at an injury site, possibly due to inflammation and hyperemia?", "Is there a visibly widened gap between bone fragments, potentially caused by severe displacement or soft tissue interposition?"], "properties": ["Does the image show a bone injury with displacement greater than 2 centimeters?", "Can you identify a fracture with a gap width between 1 and 3 centimeters?", "Is there evidence of angulation at the fracture site exceeding 20 degrees?", "Does the image reveal significant bone loss, such as a missing segment or loss greater than 2 centimeters?", "Is there marked soft tissue swelling involving the entire compartment around a fracture?", "Can you see signs of a large hematoma, with a volume possibly between 200 and 1000 milliliters?", "Does the injury appear to require an extended healing period, such as 4 to 8 months?", "Is there a high degree of bone fragmentation, with multiple large and small fragments visible?", "Can you identify a fracture that is severely comminuted or segmental in nature?", "Does the image suggest substantial blood loss, potentially in the range of 500 to 2000 milliliters?", "Are there radiographic features such as displaced, comminuted fragments, wide fracture gaps, and soft tissue shadowing present?", "Can you see bone fragments larger than 1 centimeter in size?", "Is there evidence that the local temperature at the injury site might be elevated above 38\u00b0C due to inflammation?", "Does the image show limb shortening in the range of 1 to 5 centimeters?", "Is there an indication that the pain intensity associated with the injury would be severe, possibly rated 8 to 10 out of 10?"], "relational": ["Does the image show a disruption involving large bones such as those in the lower extremities or pelvis?", "Is there evidence of structural damage to cortical or cancellous bone in the image?", "Can you identify an injury that may affect the musculoskeletal system?", "Does the image suggest possible compromise of the circulatory system near a major bone injury?", "Is there a visible abnormality in the pelvic region or upper limbs that could indicate severe bone trauma?", "Are there signs of joint involvement, such as at the hip, knee, or shoulder, associated with a major bone injury?", "Does the image show potential risk to major blood vessels like the femoral or brachial artery near a bone disruption?", "Can you see disruption of connective tissues such as ligaments, tendons, or joint capsules adjacent to a bone injury?", "Is there evidence of damage to supporting structures like the periosteum or surrounding muscles near a large bone?", "Does the image suggest possible involvement of nerves such as the sciatic, femoral, or radial nerve in the region of a bone injury?", "Are there signs of muscle disruption, such as in the quadriceps femoris or gluteus maximus, adjacent to a major bone injury?"], "contexual_behavior": ["Is there evidence of a bone injury that would immediately prevent the affected limb from supporting weight?", "Can you identify signs of disrupted blood flow or possible ischemia near a site of significant bone damage?", "Does the image suggest a bone injury so extensive that normal self-repair would be compromised?", "Are there visual cues indicating a disturbance in calcium or mineral balance at the site of a severe bone injury?", "Is there an area where limb mobility appears limited due to pain, instability, or loss of bone integrity?", "Can you see features that might increase the risk of fat embolism, such as exposed or disrupted medullary cavities?", "Is there evidence of exaggerated or prolonged inflammation, such as local edema, at a site of major bone disruption?", "Does the image show a bone injury where the segments appear misaligned or separated, suggesting delayed or non-union?", "Is there a region where the protective function of the skeleton is compromised, potentially exposing internal tissues to harm?", "Can you identify an area where bone marrow function might be impaired due to extensive damage or replacement by fibrous tissue?", "Are there signs that the metabolic demand for bone remodeling is elevated, such as increased bone turnover at a major injury site?", "Does the image suggest a reduced local immune defense or increased risk of infection at a site of severe bone injury?", "Is there evidence of abnormal bone healing, such as malunion or pseudoarthrosis, where bone fragments are misaligned or fail to unite?", "Can you see indications of nerve injury or neurological deficit adjacent to a displaced bone fragment?", "Are there features suggesting altered biomechanics or rehabilitation challenges due to weak or misaligned healing tissue?", "Is there visual evidence of increased susceptibility to infection, such as compromised soft tissue integrity at a bone injury site?", "Does the injury appear to extend into a joint or alter joint alignment, potentially causing joint dysfunction?", "Are there signs that the body's mineral balance could be impaired due to excessive bone resorption at the injury site?", "Can you identify areas of excessive bleeding or impaired hemostasis associated with damage to major blood vessels near a bone injury?", "Does the image suggest delayed restoration of normal bone architecture, such as persistent structural abnormality or poor remodeling after injury?"], "functions": ["Does the image show evidence of an injury that could lead to hypovolemia or shock?", "Is there a disruption visible that might result in multi-organ dysfunction?", "Can you identify a site where normal bone healing appears delayed or vascular supply seems compromised?", "Does the image suggest extensive tissue damage that could impair regeneration?", "Is there visual evidence of significant blood loss or features indicating hemodynamic instability?", "Can you see signs that might be associated with a robust inflammatory response, such as swelling or redness?", "Does the image suggest the possibility of systemic complications like fat embolism due to marrow fat release?", "Is there a region where musculoskeletal function could be severely impaired due to structural instability?", "Can you identify features that might indicate impaired mobility or pain?", "Does the image suggest a disruption in mineral metabolism, such as signs of calcium or phosphate imbalance?", "Is there evidence of overwhelmed tissue repair mechanisms or delayed regeneration at the injury site?", "Can you see signs that might indicate increased susceptibility to infection or altered immune response?", "Does the image show features that could elevate the risk of sepsis or tissue necrosis?", "Is there evidence suggesting increased intracompartmental pressure or vascular compromise that could lead to compartment syndrome?", "Can you identify signs of marrow content release, such as fat embolism or dissemination of hematopoietic cells?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify an area that would be expected to have a mildly acidic pH, between 4.5 and 5.5?", "Is there a part of the image that might have a water content similar to other skin tissues, around 60 to 70 percent?", "Is there an area that could be composed of cell types such as keratinocytes, melanocytes, myoepithelial cells, or ductal epithelial cells?"], "relational": ["Is there a structure present that belongs to both the integumentary and reproductive systems?", "Is there a structure likely innervated by the fourth intercostal nerve?", "Is there an object that is centrally positioned within a pigmented area on the chest?"], "contexual_behavior": [], "functions": ["Can you identify an area that provides tactile or olfactory cues important for infant feeding behavior?", "Is there a visible structure that might change shape or sensitivity in response to temperature?", "Is there a part of the image that could transmit tactile stimulation to trigger the let-down reflex?"]}}, "view of head with scalp": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling on the outer covering of the head that could suggest trauma, infection, or an allergic reaction?", "Can you observe any areas of discoloration on the surface of the head, such as bruising or pigment changes?", "Does the image show thinning of the outermost layer of the head, possibly due to aging or nutritional deficiency?", "Are there visible lesions present on the surface covering of the head that might indicate infection, autoimmune disease, or neoplastic processes?", "Is there a region on the head that appears unusually pale, which could be related to anemia or poor blood flow?", "Can you identify any thickening of the outer layer of the head, as might be seen in chronic inflammatory or infiltrative conditions?", "Is there increased redness on the surface of the head, suggesting inflammation or vascular dilation?", "Do you see any scaling or flakiness on the head\u2019s surface, which could be associated with dermatological conditions like dandruff or psoriasis?", "Is there noticeable hair loss on the top of the head, possibly due to hormonal changes or autoimmune disorders?", "Does the surface of the head appear oily, which might indicate increased sebaceous gland activity?", "Are there areas on the head that look dry, possibly due to decreased sebum production or environmental exposure?", "Can you observe crusts forming on the head\u2019s surface, which could result from infection, eczema, or healing wounds?", "Is there evidence of increased blood vessels or vascularity on the outer covering of the head, as might occur with inflammation or neoplastic processes?", "Does the surface of the head appear tender or sensitive, possibly due to infection, trauma, or inflammation?", "Are there any ulcers visible on the head\u2019s surface, which could be due to chronic infection, malignancy, or autoimmune disease?", "Can you see signs of bruising on the head, such as areas of blue or purple coloration, which might result from trauma or bleeding disorders?", "Is there flakiness present on the head\u2019s surface, suggesting excessive desquamation?", "Does the texture of the head\u2019s outer covering appear altered, possibly due to scarring or chronic inflammation?", "Are there nodules present on the surface of the head, which could indicate cysts, tumors, or granulomatous disease?", "Does any part of the head\u2019s surface appear shiny, which might be due to atrophy, scarring, or hair loss?"], "properties": ["Does the image show a structure with an ovoid or rounded contour consistent with the human skull?", "Can you identify an area whose circumference would likely fall within the adult range of 54 to 58 centimeters?", "Is there a region that could have a surface area between 500 and 700 square centimeters in adults?", "Does the visible area display a color ranging from pale to light brown, reflecting variations in skin pigmentation?", "Can you observe a region where the thickness appears to be within the range of 3 to 8 millimeters?", "Is there evidence of a surface with a hair density of approximately 100 to 150 hairs per square centimeter?", "Does the image show a smooth and pliable texture, possibly due to a layered structure?", "Can you identify an area that would likely contain cell types such as keratinocytes, melanocytes, fibroblasts, or dermal papilla cells?", "Is there a region where the water content could be estimated at around 60 to 70 percent by weight?", "Does the visible area suggest a lipid content of about 10 to 15 percent, possibly due to sebaceous gland secretions?", "Can you observe variations in pigmentation that might reflect different levels of melanin concentration?", "Is there a region that could maintain a temperature in the range of 33 to 35 degrees Celsius?", "Does the image suggest a high density of blood vessels, such as an extensive capillary network within the dermis?", "Can you infer the presence of a substantial number of sensory nerve fibers supporting tactile or pain sensation?", "Is there evidence of significant collagen content providing structural integrity to the dermal layer?"], "relational": ["Does the image show a region that includes the scalp, forehead, or occipital area?", "Can you identify any bones such as the frontal, parietal, temporal, or occipital bones in the depicted view?", "Is there evidence of muscles like the occipitofrontalis or temporalis in the visible structures?", "Does the image display multiple layers such as skin, connective tissue, or aponeurosis overlying a bony surface?", "Can you see any features that might correspond to nerves like the supraorbital or greater occipital nerve?", "Are there visible blood vessels such as the superficial temporal artery or scalp veins in the region shown?", "Is there a structure where the scalp overlies skull bones, separated by connective tissue layers?", "Can you identify dense connective tissue, loose areolar tissue, or an epicranial aponeurosis in the image?", "Does the image contain sensory structures such as hair follicles, sebaceous glands, or sweat glands?", "Are there visible regions adjacent to the main area, such as the temples or upper part of the auricular region?"], "contexual_behavior": ["Does the image show evidence of trauma, laceration, or atrophy that could compromise the protective function of the outermost covering of the head?", "Is there any indication of temperature regulation, such as vasoconstriction or vasodilation, in response to environmental extremes like cold or heat?", "Can you identify signs of skin disease, such as scaling or redness, that might suggest impaired barrier function due to conditions like psoriasis, eczema, or dermatitis?", "Is there visible redness or swelling that could indicate increased blood flow from inflammation or injury?", "Does the image suggest any sensory impairment, such as changes in skin texture or appearance, that might be associated with neuropathy or nerve damage?", "Are there visual cues, such as increased oiliness, that could indicate heightened sebum production possibly due to hormonal changes like those in puberty or pregnancy?", "Is there evidence of extensive tissue loss, infection, or poor vascularization that might suggest decreased healing capacity after injury?", "Can you see signs of local immune activation, such as swelling or pus, that could indicate an infection triggering immune cell recruitment?", "Is there a visible reduction in subcutaneous tissue or fat that could suggest diminished cushioning for the skull after injury or surgery?", "Does the image show increased sweat or moisture that might be associated with physical exertion and activation of sweat glands?", "Are there signs of disrupted hair growth, such as thinning or patchy areas, that could be related to stress, illness, or hormonal imbalance?", "Can you observe differences in pigmentation or signs of sunburn that might reflect varying responses to UV exposure based on skin type or melanin content?", "Is there evidence of decreased vascular supply, such as pallor or thinning, that could be linked to systemic diseases like atherosclerosis or diabetes?", "Does the image suggest sensory loss, such as lack of response to touch or visible nerve injury, possibly due to cranial or peripheral nerve damage?", "Are there visual indicators of increased blood flow or sweating that might suggest an active role in thermoregulation during fever?"], "functions": ["Does the image show a region that acts as a protective barrier for the head by cushioning external forces?", "Is there evidence of a structure that aids in temperature regulation of the head through a rich blood supply or sweat glands?", "Can you identify an area that enables sensation by containing numerous nerve endings for detecting touch or pain?", "Does the image display a region that supports hair growth by anchoring hair follicles and providing vascularization?", "Is there a visible layer that absorbs and disperses mechanical impacts to prevent injury to deeper tissues?", "Can you see a surface that helps prevent infection of underlying tissues through an intact skin barrier?", "Is there an area that would facilitate wound healing by promoting tissue repair and regeneration on the head?", "Does the image show a region with glands that distribute sweat or sebum to maintain moisture and scalp health?", "Can you identify a structure with a vascular supply important for nutrient delivery and supporting hair maintenance?", "Is there a layer that interacts with the underlying skull by providing shock absorption and reducing force transmission to bone?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system and projects into the vaginal canal?", "Does the image include an outer portion of the cervix that is connected to both the uterus and the vagina?", "Can you identify a region that is part of the ectocervix and lies adjacent to the cervical canal?"], "contexual_behavior": ["Does the image show signs of impaired tissue repair, such as ongoing tissue damage or chronic inflammatory changes?", "Does the image show signs of impaired cellular turnover, such as abnormal cell proliferation or differentiation, due to inflammatory processes?", "Is there visual evidence of increased recruitment of immune cells in response to tissue damage or infection?"], "functions": ["Can you identify a region where immune cells like neutrophils or macrophages might be recruited to the site of inflammation?", "Does the image show signs that pro-inflammatory mediators might be present, such as increased immune cell presence or tissue swelling?", "Does any structure in the image display signs of epithelial disruption or compromised tissue integrity?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Is there an organ that appears shrunken, possibly indicating menopause, surgical removal, or atrophy?", "Can you identify fluid accumulation within or around a structure, as might be seen with cysts, edema, or hyperstimulation syndrome?", "Is there visible surface scarring on an organ, possibly due to repeated ovulation, surgical intervention, or inflammation?"], "properties": ["Does the image contain an object with a temperature similar to core body temperature, around 37 degrees Celsius?", "Can you identify an object that may have several hundred to several hundred thousand small follicles, depending on age?", "Is there a structure that contains specialized cells such as oocytes or granulosa cells?"], "relational": ["Does the image include an object adjacent to the pelvic wall or rectum?", "Does the image show a structure that is part of the female reproductive system?", "Can you identify an object located in the pelvic cavity?"], "contexual_behavior": ["Is there a structure that might stop ovulating under chronic stress because of altered hypothalamic-pituitary signaling?", "Can you identify an object that increases androgen production in certain endocrine disorders such as congenital adrenal hyperplasia?", "Can you identify an object that increases its metabolic activity to support follicle rupture and oocyte release during ovulation?"], "functions": ["Does the image contain an object that alters follicle growth and hormone secretion during the menstrual cycle?", "Can you see an organ that interacts with the hypothalamic-pituitary axis through hormonal feedback mechanisms?", "Is there a structure present that contributes to the maintenance of secondary sexual characteristics in females?"]}}, "scalp retracted": {"yes_questions": {"contexual_properties": ["Is there evidence of a structure that has been exposed by the use of surgical retractors?", "Can you identify tissue that appears under increased tension, possibly due to prolonged mechanical force?", "Does the image show an area where color changes suggest altered blood flow or localized ischemia?", "Is there visible swelling that could indicate tissue trauma or an inflammatory response?", "Can you see signs of edema that might result from impaired venous or lymphatic drainage?", "Is there evidence of bleeding or capillary damage, such as small hemorrhages in the tissue?", "Does any region appear less elastic, possibly due to tissue stretching or repeated mechanical stress?", "Can you identify bruising or subcutaneous hemorrhage that might result from vessel rupture?", "Is there a noticeable change in thickness, possibly due to swelling or compression of tissue?", "Does any area appear unusually pale, suggesting reduced perfusion or temporary ischemia?", "Is there a region that looks drier than surrounding tissue, potentially from barrier disruption or prolonged air exposure?", "Can you see signs of increased fragility, such as tissue that appears damaged from repeated trauma?", "Is there abnormal texture, such as firmness or irregularity, that could be due to fibrosis or chronic edema?", "Does any area show signs of delayed healing, possibly from tissue injury or vascular compromise?", "Is there a visible change in temperature, such as redness or pallor, that might indicate altered blood flow or environmental exposure?"], "properties": ["Is there a region in the image where tissue appears taut and glistening with underlying connective structures exposed?", "Can you identify an area where the tissue thickness seems to be within the 5 to 7 millimeter range, varying by location?", "Does the image show a surface that is pale pink to reddish, possibly due to increased visibility of blood vessels?", "Is there a tissue area that appears moderately elastic, able to stretch and return to its original position after manipulation?", "Can you observe a slightly moist surface, potentially due to tissue fluids or minor bleeding?", "Does any part of the image suggest a peripheral skin temperature in the range of 33 to 35 degrees Celsius?", "Is there a region with a smooth and firm texture, possibly interrupted by visible hair follicles or connective tissue?", "Can you see evidence of reduced blood flow, such as compressed vessels, compared to surrounding tissue?", "Is there an area where the tissue plane appears stretched and under increased tension?", "Does the image show a surface that would likely have a slightly acidic pH, between 4.5 and 5.5?"], "relational": ["Does the image show a region of the head where underlying bones such as the frontal or parietal bones are visible?", "Can you identify an area where layers like skin and connective tissue have been moved aside to expose deeper structures?", "Is there a visible space exposing the pericranium or subgaleal region?", "Does the image reveal skull bones that are normally covered by multiple tissue layers?", "Can you see anatomical features such as the occipitofrontalis or temporoparietalis muscles adjacent to an exposed area?", "Is there evidence of blood vessels like the superficial temporal artery or occipital artery in a region where overlying tissue is absent?", "Does the image display nerves such as the supraorbital or greater occipital nerve in an area lacking its usual covering?", "Can you observe the anatomical boundaries defined by the supraorbital margins, superior nuchal lines, or zygomatic arches in relation to an exposed cranial surface?", "Is there a region where the pericranium is directly visible without the usual overlying layers?", "Does the image show facial muscles or loose areolar tissue adjacent to a region where deeper cranial structures are exposed?"], "contexual_behavior": ["Does the image show an area where blood flow to tissues might be reduced due to compression of blood vessels?", "Is there evidence of underlying tissues being exposed to the external environment, indicating a loss of the normal protective barrier?", "Can you identify a region where the risk of infection may be increased because skin integrity is compromised and subcutaneous layers are visible?", "Does the image display tissue tension or displacement that could disrupt normal wound closure or cellular repair processes?", "Is there a visible reduction in the insulating layers that would decrease the ability to regulate temperature or increase heat loss?", "Can you see signs suggesting that nerve function or sensation might be impaired due to stretching or exposure of nerves?", "Is there an area where wound healing could be delayed because of poor vascularization or tissue edges under tension?", "Does the image show evidence of increased bleeding or vessel injury, such as visible hemorrhage, in a region where tissue has been pulled back?", "Is there a loss of soft tissue layers that would normally cushion the skull, potentially increasing vulnerability to impact?", "Can you observe changes in the distribution or appearance of hair follicles that might indicate altered growth or ischemic changes due to disrupted blood supply?"], "functions": ["Does the image show a surgical field where access to the cranial vault is unobstructed?", "Is there evidence that deeper cranial structures are visible due to the movement of soft tissue away from the operative site?", "Can you see indications that the scalp has been stabilized to minimize unnecessary tissue manipulation?", "Does the image suggest that bleeding vessels are more easily identified and controlled in the operative area?", "Is the visibility of the surgical field enhanced by the removal of soft tissue from the area of interest?", "Are there visual cues that neural tissues are protected by clear separation between tissue layers?", "Does the operative site appear to be maintained in a way that reduces the risk of contamination?", "Can you observe that scalp flaps are managed and stabilized, preventing interference with the surgical procedure?"]}, "no_questions": {"contexual_properties": ["Is there evidence of cells with several internal inclusions rather than a single one?", "Does the image contain cells where the cytoplasm is interrupted by multiple separate inclusions?", "Can you identify cellular structures that display multiple discrete bodies or deposits inside the cytoplasmic area?"], "properties": ["Do you see cytoplasmic structures with a higher density than the surrounding cytoplasm?", "Does the image show intracellular structures that are generally spherical or ovoid in shape and measure between 0.2 and 2 micrometers in diameter?", "Can you identify intracellular droplets that suggest a substantial lipid content?"], "relational": ["Does the image show cells that contain non-membranous entities within their cytoplasm?", "Are there visible inclusions in the cytoplasm of cells such as hepatocytes, neurons, macrophages, or adipocytes?", "Does the image contain cells with inclusions such as glycogen granules, lipid droplets, pigment granules, or crystalline inclusions?"], "contexual_behavior": ["Are there visible cytoplasmic features within cells that suggest the presence of several inclusions?", "Does the image show cells containing more than one distinct structure within their cytoplasm?", "Can you identify any cells that display multiple internal inclusions or bodies?"], "functions": ["Does the image show specialized cytoplasmic structures that could be involved in protein or lipid storage, such as protein granules or lipid droplets?", "Are there visible aggregates or bodies that could indicate a cellular response to stress, such as the storage of damaged or misfolded proteins?", "Are there visible inclusions that could correspond to pigment granules or lipid droplets?"]}}, "yellow foci": {"yes_questions": {"contexual_properties": ["Does the image show any areas that have increased in size, suggesting ongoing lipid accumulation or tumor growth?", "Are there fewer abnormal spots visible, which could indicate disease remission or a positive response to therapy?", "Can you identify regions that appear more prominent, possibly due to intensified inflammation or cellular infiltration?", "Is there evidence of color change in any lesions, which might suggest hemorrhage or necrosis altering their composition?", "Do you observe new abnormal areas in locations not previously affected, indicating possible disease spread or new lesion formation?", "Are there regions that appear paler, which could be a sign of increased lipid content or advanced necrosis?", "Does the image show an increased number of abnormal foci, consistent with disease progression or ongoing injury?", "Can you see any lesions that have merged together, suggesting coalescence due to expansion or tissue breakdown?", "Are there visible changes in the texture of any lesions, such as signs of fibrosis, calcification, or liquefaction?", "Do any abnormal areas have altered borders, possibly due to inflammation, fibrosis, or tumor invasion affecting the lesion margins?", "Are there regions that appear raised or indurated, which could be due to increased cellular infiltration or fibrous tissue deposition?", "Can you identify lesions with changes in composition, such as areas of necrosis, calcification, or lipid accumulation?", "Do any abnormal foci appear softer or firmer, indicating changes in consistency from liquefaction or fibrosis?", "Are there lesions that have shrunk or resolved, suggesting healing or a response to treatment?", "Is there evidence of hemorrhage associated with any abnormal areas, possibly due to vascular injury or lesion rupture?", "Do you see regions surrounded by inflammation, indicating an acute or chronic immune response?", "Are there abnormal foci present that could be associated with metabolic, infectious, or neoplastic disease progression?", "Can you identify areas that suggest lipid accumulation, as seen in metabolic disorders like steatosis or xanthomatosis?", "Are there lesions showing signs of necrosis, possibly resulting from severe cellular injury or ischemia?", "Do any regions display a change in density on imaging, which could reflect alterations in internal composition such as calcification or increased lipid content?"], "properties": ["Does the image show small, pale yellow areas ranging from 1 to 5 millimeters in diameter?", "Can you identify round or oval structures with a soft or greasy appearance?", "Are there multiple pale yellow spots, varying from a few to several dozen, visible within the tissue section?", "Do you observe any regions approximately 2 to 5 millimeters across that appear different from the surrounding tissue?", "Is there evidence of clusters composed mainly of lipids, hepatocytes, and inflammatory cells?", "Can you see areas where the lipid content seems significantly higher than in the surrounding tissue?", "Are there visible regions that might contain hepatocytes with steatosis, macrophages, or occasional neutrophils?", "Do any areas appear to have reduced protein concentration compared to adjacent tissue?", "Is there a region where the water content seems lower than in the surrounding healthy tissue?", "Can you identify spots that appear less dense than the normal parenchyma, possibly due to high lipid content?", "Under microscopic view, do you see clusters of swollen hepatocytes with clear cytoplasm?", "Are there randomly or focally distributed pale yellow regions within the liver parenchyma?", "Can you find areas whose estimated volume falls between 4 and 65 cubic millimeters?"], "relational": ["Does the image show any regions within the hepatic, digestive, or endocrine systems that appear visually distinct?", "Can you identify areas within the liver parenchyma, adipose tissue, or connective tissue that differ in appearance from their surroundings?", "Is there a focus within the liver, pancreas, or subcutaneous tissue that stands out due to its color or texture?", "Are there visible clusters of cells that could include hepatocytes, lipid-laden macrophages, or inflammatory cells?", "Do you observe any areas surrounded by normal parenchyma, fibrous septa, or blood vessels?", "Is there a region that appears to abut or infiltrate organs such as the gallbladder, pancreas, or intestine?", "Can you detect lesions that resemble steatotic nodules, lipogranulomas, or xanthomas?", "Are there well-demarcated areas characterized by yellow discoloration or apparent fat accumulation?", "Does the image contain features that might affect the hepatic, metabolic, or immune systems?", "Are there pathological structures such as fibrosis, inflammatory infiltrates, or necrotic areas adjacent to any visually distinct foci?"], "contexual_behavior": ["Does the image show regions within hepatic tissue that increase in number during liver injury?", "Are there areas that might indicate impaired metabolic activity due to exposure to hepatotoxic agents?", "Can you identify focal expansions within the liver that could be associated with excessive lipid accumulation from a high-fat diet?", "Does the image contain regions that may demonstrate reduced detoxification capacity as seen in disease progression?", "Are there areas within the liver that appear to have lost regenerative ability, possibly due to chronic inflammation?", "Can you see regions that might exhibit altered enzyme activity in response to carcinogen exposure?", "Does the image reveal areas that could be experiencing functional decline as a result of oxidative stress?", "Are there regions that might show disrupted cellular signaling under conditions of oxygen deprivation?", "Can you identify areas with increased lipid accumulation, potentially indicating steatosis during metabolic syndrome?", "Does the image show regions that could have impaired protein synthesis, as seen in advanced liver disease?", "Are there areas within the liver that might display changes in secretory behavior during fibrosis development?", "Can you see regions that may contribute less to hepatic clearance, possibly reflecting age-related functional decline?", "Does the image reveal areas that appear to have increased proliferation following partial hepatectomy?", "Are there regions that might display altered glucose metabolism, as could occur during insulin resistance?", "Can you identify areas that may have lost normal function after exposure to hepatotoxins?"], "functions": ["Does the image show any localized lesions that could indicate lipid accumulation or necrosis?", "Can you identify areas that might represent sites of cellular degeneration or inflammation?", "Are there visible regions that could correspond to fat deposition within the tissue?", "Does the image contain any foci where inflammatory cells or lipid-laden macrophages might be accumulating?", "Can you see evidence of immune cell infiltration or a localized tissue response to injury or infection?", "Are there regions that suggest recruitment of inflammatory cells, such as macrophages or neutrophils?", "Does the image display any features that could disrupt normal tissue metabolism or promote lipid storage?", "Can you identify markers that might indicate underlying disease processes like steatosis, infection, or tissue injury?", "Are there areas that could signify ongoing tissue damage, inflammation, or metabolic disturbance?", "Does the image show sites where cytokine release or immune cell activation might be occurring?"]}, "no_questions": {"contexual_properties": ["Does the image show signs of inflammation, such as redness or swelling, possibly resulting from infection, autoimmune reaction, or injury?", "Is there a visible accumulation of fluid within a structure, suggesting duct obstruction or cyst formation?", "Does any structure appear to have decreased secretions, possibly due to atrophy or hormonal deficiency?"], "properties": ["Can you see a structure likely composed of secretory epithelial cells or myoepithelial cells?", "Is there an object that appears well hydrated, possibly containing 70\u201380% water by mass?", "Is there an object present whose weight might vary from less than a gram to around 30 grams depending on its type?"], "relational": ["Is there an object adjacent to muscles, blood vessels, nerves, or bones that could indicate a secretory function?", "Does the image contain a structure that might interact anatomically with the brain, kidneys, liver, or reproductive organs?", "Does the image contain something resembling sebaceous, sweat, or salivary tissue?"], "contexual_behavior": ["Does the image contain an object that might fail to respond to regulatory signals due to insulin resistance or beta-cell dysfunction, as seen in diabetes?", "Does the image show a structure that could fail to regulate metabolism due to insufficient thyroid hormone production, as in hypothyroidism?", "Can you see a structure that would decrease its secretion when exposed to medications that inhibit glandular activity or block signaling pathways?"], "functions": ["Is there a structure present that could regulate fluid and electrolyte balance by releasing hormones such as aldosterone or antidiuretic hormone?", "Is there a visible object that could support immune defense by producing substances such as antibodies or antimicrobial peptides?", "Can you see an object that might influence blood pressure by secreting hormones affecting vascular tone or fluid retention?"]}}}
[ { "answer": "the most common pathway", "extracted_concepts": [ "er-positive cancers" ], "question": "what leads to er-positive cancers?" }, { "answer": "yes", "extracted_concepts": [ "er-positive cancers" ], "question": "does the most common pathway lead to er-positive cancers?" }, { "answer": "no", "extracted_concepts": [ "two helical spirochetes", "er-positive cancers" ], "question": "does two helical spirochetes lead to er-positive cancers?" }, { "answer": "morphologically recognized precursor lesions", "extracted_concepts": [ "flat epithelial atypia", "gains of chromosome 1", "losses of chromosome 16", "invasive er-positive carcinomas", "adh", "mutations of pik3ca", "gene encoding pi3k", "morphologically recognized precursor lesions", "dcis" ], "question": "what include flat epithelial atypia, adh, and dcis, all of which share certain genomic events with invasive er-positive carcinomas, such gains of chromosome 1, losses of chromosome 16, and mutations of pik3ca the gene encoding pi3k?" }, { "answer": "flat epithelial atypia", "extracted_concepts": [ "flat epithelial atypia", "morphologically recognized precursor lesions" ], "question": "what do morphologically recognized precursor lesions include?" }, { "answer": "yes", "extracted_concepts": [ "flat epithelial atypia", "morphologically recognized precursor lesions", "dcis", "adh" ], "question": "do morphologically recognized precursor lesions include flat epithelial atypia, adh, and dcis?" }, { "answer": "no", "extracted_concepts": [], "question": "do the principal cellular alterations that characterize reversible cell injury and necrosis include flat epithelial atypia, adh, and dcis?" }, { "answer": "er-positive carcinomas", "extracted_concepts": [ "er-positive carcinomas", "luminal", "gene expression profiling" ], "question": "what are classified as luminal by gene expression profiling?" }, { "answer": "yes", "extracted_concepts": [ "luminal", "cancers", "gene expression profiling" ], "question": "are these cancers classified as luminal by gene expression profiling?" }, { "answer": "no", "extracted_concepts": [ "luminal", "skin stem cells", "gene expression profiling" ], "question": "are skin stem cells classified as luminal by gene expression profiling?" }, { "answer": "luminal", "extracted_concepts": [ "germline brca2 mutations", "type of cancer", "luminal" ], "question": "what is the type of cancer that arises most commonly in individuals with germline brca2 mutations?" }, { "answer": "yes", "extracted_concepts": [ "germline brca2 mutations", "type of cancer", "cancer" ], "question": "is this the type of cancer that arises most commonly in individuals with germline brca2 mutations?" }, { "answer": "no", "extracted_concepts": [ "germline brca2 mutations", "flow cytometry", "cancer" ], "question": "is show flow cytometry the type of cancer that arises most commonly in individuals with germline brca2 mutations?" }, { "answer": "a possible precursor lesion", "extracted_concepts": [ "precursor lesion", "apocrine dcis", "atypical apocrine adenosis" ], "question": "what is atypical apocrine adenosis, which shares features with apocrine dcis?" }, { "answer": "atypical apocrine adenosis", "extracted_concepts": [ "possible precursor lesion", "apocrine dcis", "atypical apocrine adenosis" ], "question": "what is a possible precursor lesion, which shares features with apocrine dcis?" }, { "answer": "no", "extracted_concepts": [ "apocrine dcis", "head atypical apocrine adenosis" ], "question": "is the head atypical apocrine adenosis, which shares features with apocrine dcis?" }, { "answer": "the least common but molecularly most distinctive type of breast cancer", "extracted_concepts": [ "negative for er and her2 (triple negative)", "triple negative", "breast cancer", "the least common but molecularly most distinctive type of breast cancer" ], "question": "what is negative for er and her2 (triple negative)?" }, { "answer": "negative for er and her2", "extracted_concepts": [ "her2", "breast cancer", "er", "negative for er and her2" ], "question": "what is the least common but molecularly most distinctive type of breast cancer?" }, { "answer": "yes", "extracted_concepts": [ "triple negative", "her2", "negative for er", "breast cancer", "er", "negative for her2" ], "question": "is the least common but molecularly most distinctive type of breast cancer negative for er and her2 triple negative ; blue arrow?" }, { "answer": "no", "extracted_concepts": [ "histologic features", "her2", "er", "triple negative" ], "question": "are histologic features negative for er and her2 triple negative?" }, { "answer": "the majority of triple-negative cancers", "extracted_concepts": [ "basal-like", "triple-negative cancers", "gene expression profiling" ], "question": "what are classified as basal-like by gene expression profiling?" }, { "answer": "basal-like", "extracted_concepts": [ "basal-like", "triple-negative cancers" ], "question": "what are the majority of triple-negative cancers classified as?" }, { "answer": "yes", "extracted_concepts": [ "basal-like", "triple-negative cancers", "gene expression profiling" ], "question": "are the majority of triple-negative cancers classified as basal-like by gene expression profiling?" }, { "answer": "no", "extracted_concepts": [ "advanced organizing pneumonia", "basal-like", "gene expression profiling" ], "question": "is advanced organizing pneumonia classified as basal-like by gene expression profiling?" } ]	["two helical spirochetes", "cancers", "negative for er and her2 (triple negative)", "apocrine dcis", "head atypical apocrine adenosis", "adh", "luminal", "atypical apocrine adenosis", "cancer", "triple-negative cancers", "dcis", "negative for her2", "flat epithelial atypia", "gains of chromosome 1", "basal-like", "losses of chromosome 16", "her2", "type of cancer", "precursor lesion", "er", "skin stem cells", "invasive er-positive carcinomas", "triple negative", "negative for er", "possible precursor lesion", "mutations of pik3ca", "gene encoding pi3k", "breast cancer", "negative for er and her2", "the least common but molecularly most distinctive type of breast cancer", "er-positive cancers", "germline brca2 mutations", "advanced organizing pneumonia", "er-positive carcinomas", "flow cytometry", "histologic features", "gene expression profiling", "morphologically recognized precursor lesions"]	{"two helical spirochetes": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show two microorganisms with a helical shape and flexible cell bodies?", "Are there two structures present that could belong to the Spirochaetaceae family?", "Can you identify two entities that might colonize mucous membranes or blood vessels?", "Does the image contain two objects that could be found in body fluids such as blood or cerebrospinal fluid?", "Are there two organisms that interact with epithelial or endothelial tissues?", "Can you see two structures that possess periplasmic flagella and an outer membrane?", "Is there evidence of two microorganisms capable of corkscrew motility?", "Are there two entities that could cross anatomical barriers like the blood-brain barrier?", "Does the image show two organisms structurally similar to Leptospira, Borrelia, or Treponema?", "Can you identify two objects that might trigger innate immunity or antibody production?", "Are there two microorganisms that could affect organs such as the liver, kidneys, or heart?", "Does the image reveal two bacteria with both a cytoplasmic membrane and a peptidoglycan layer?"], "contexual_behavior": [], "functions": ["Does the image show two organisms with a helical shape that could be involved in causing infectious diseases?", "Can you identify two structures that might move through tissues using axial filaments for corkscrew-like motility?", "Are there two entities present that appear to be adhering to host surfaces or penetrating epithelial barriers?", "Does the image include two objects that could evade immune detection by varying their surface proteins?", "Can you see two structures that might be binding to extracellular matrix components or forming biofilms?", "Are there two organisms that could be disseminating through tissues and potentially inducing inflammation?", "Does the image show two entities that might secrete enzymes to degrade host barriers for tissue invasion?", "Can you identify two structures that appear to be attaching to or entering host cells?", "Are there two objects that could be performing glycolysis or anaerobic respiration for energy production within a host?", "Does the image contain two organisms that might adapt to different environments by altering gene expression or membrane composition?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there visual evidence of a reaction that might require a pH between 6.0 and 7.5 for optimal results?", "Does the image suggest that the staining reagents might have a shelf life of 6 to 24 months depending on storage conditions?", "Is there evidence in the image that buffer solutions were used as part of the staining process?"], "relational": ["Is there a specimen that could be formalin-fixed, paraffin-embedded tissue, a frozen section, or a cytology smear?", "Does the image show a tissue sample that could be from a tumor or a normal organ?", "Is there visualization of cellular organelles such as nuclei or mitochondria?"], "contexual_behavior": [], "functions": ["Is there visual information suggesting the detection of markers indicative of particular stages or lineages of cell development?", "Is there evidence of unique cellular markers being labeled to distinguish between different cell types?", "Does the image reveal areas where disease markers are detected through the presence or absence of specific molecular targets?"]}}, "cancers": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to be increasing in size due to rapid cell proliferation?", "Can you identify an area that seems to be shrinking, possibly as a result of effective therapy or cell death?", "Does the image show a region with color changes that might indicate altered blood supply, tissue death, or bleeding?", "Is there evidence of increased blood vessel formation supplying a particular mass?", "Can you see a region within a mass that appears necrotic, possibly due to insufficient blood supply?", "Are there visible calcifications within a mass that could suggest mineralization in degenerating tissue?", "Does any area appear more solid, potentially due to increased cellular density or supporting tissue growth?", "Is there a part of a mass that looks cystic, indicating fluid-filled spaces from tissue degeneration?", "Can you observe features suggestive of increased cellular atypia, such as abnormal cell shapes or sizes?", "Does the density of a mass vary, possibly reflecting differences in cellularity, necrosis, fibrosis, or cystic transformation?", "Is there evidence that a structure is invading or infiltrating surrounding tissues, suggesting a breach of normal boundaries?", "Do you see a mass with irregular or non-uniform borders, possibly due to infiltration into adjacent tissues?", "Are there areas with a high number of dividing cells, indicating elevated mitotic activity?", "Can you identify regions where fluid has accumulated, perhaps due to lymphatic blockage or cystic change?", "Is there a lesion with surface breakdown or ulceration, suggesting disruption of the overlying tissue?", "Does any area show signs of increased metabolic activity, such as high glucose uptake?", "Are there regions within a mass that appear heterogeneous, with mixed areas of necrosis, bleeding, fibrosis, or cystic change?", "Can you see evidence of bleeding within a mass, possibly due to ruptured or invaded blood vessels?", "Is there a structure that might be associated with elevated levels of specific biomarkers?", "Do you observe changes in the texture of a mass, potentially due to variations in cellularity, fibrosis, necrosis, or cystic degeneration?"], "properties": ["Is there a structure in the image that measures several millimeters to centimeters in size, suggesting abnormal tissue growth?", "Can you identify an area that might show evidence of rapid progression over weeks to months?", "Does the image reveal a mass composed predominantly of abnormal cells, possibly accompanied by stromal, immune, or endothelial cells?", "Is there a region where the number of dividing cells appears unusually high, indicating an elevated mitotic index?", "Can you observe cells with enlarged nuclei relative to their cytoplasm, suggesting a high nuclear-to-cytoplasmic ratio?", "Is there evidence of cells with abnormal or increased DNA content compared to surrounding tissue?", "Does the image show features consistent with chromosomal abnormalities, such as irregular nuclear shapes or sizes?", "Can you identify an area with increased vascularization or a higher density of small blood vessels than normal tissue?", "Is there a region that might exhibit elevated metabolic activity, such as increased glycolysis or altered energy metabolism?", "Does the tissue appear to be poorly differentiated or show a moderate to high histological grade?", "Is there evidence of protein expression patterns such as high levels of Ki-67 or p53 in any part of the tissue?", "Can you see indications of a high proliferation index, such as a large proportion of cells actively dividing?", "Is there a region that might correspond to increased glucose uptake, as would be visualized in FDG-PET imaging?", "Are there areas within the tissue that could be hypoxic, possibly indicated by regions lacking normal vascular supply?", "Does the microenvironment of the tissue suggest an acidic pH, potentially visible as areas of cellular stress or necrosis?", "Can you identify features that might reflect a high mutation burden, such as marked cellular or nuclear variability?", "Is there evidence of increased lipid content, such as changes in membrane density or structure?", "Does the tissue appear to have a high water content, possibly indicated by its texture or translucency?", "Are there regions in the image where the tissue is white, gray, or tan, possibly with areas of necrosis or hemorrhage?", "Can you assess whether the density of the tissue is similar to or slightly higher than that of normal soft tissue, around 1.05\u20131.10 grams per cubic centimeter?"], "relational": ["Does the image show any abnormality affecting the respiratory, digestive, reproductive, nervous, or musculoskeletal systems?", "Can you identify a lesion that appears to arise from epithelial, connective, muscle, or nervous tissue?", "Is there evidence of abnormal proliferation of cells such as epithelial cells, lymphocytes, melanocytes, or fibroblasts?", "Does the image display any irregularity in regions like the lung, breast, colon, prostate, or skin?", "Can you see any mass or lesion that appears to invade blood vessels, lymph nodes, adjacent organs, or bone?", "Is there visual evidence suggesting spread through lymphatic vessels, such as enlarged or abnormal lymph nodes?", "Does the image show a structure that could have originated from the lung, breast, colon, prostate, liver, or skin?", "Can you identify any abnormality that might interact with the immune, circulatory, or endocrine systems during its progression?", "Is there a visible disruption of anatomical barriers such as the basement membrane, blood-brain barrier, capsule, or fascia?", "Does the image reveal features consistent with metastasis, such as involvement of lymphatic vessels, blood vessels, the extracellular matrix, or secondary organs?"], "contexual_behavior": ["Does the image show a structure that appears to be growing rapidly in areas where oxygen levels might be low?", "Can you identify a region where immune cells seem unable to infiltrate or affect abnormal tissue, possibly due to immune evasion mechanisms?", "Is there evidence of increased formation of new blood vessels, potentially in response to hypoxic conditions or secretion of pro-angiogenic factors?", "Does the image suggest the presence of tissue that might be resistant to chemotherapy, such as by showing signs of drug efflux or enhanced DNA repair?", "Can you observe areas where abnormal cells appear to be utilizing alternative metabolic pathways, such as increased glycolysis under nutrient deprivation?", "Is there visual evidence of abnormal tissue spreading to distant or adjacent sites, possibly facilitated by inflammation or cytokine signaling?", "Does the image indicate suppression of programmed cell death, such as regions with high cell density and little evidence of apoptosis?", "Can you see signs of increased cell proliferation following what might be radiation exposure, such as clusters of rapidly dividing cells?", "Is there evidence that abnormal tissue is less responsive to targeted therapies, possibly due to resistance mutations or activation of alternative signaling pathways?", "Do you observe invasive growth into surrounding tissues, potentially associated with reduced cell adhesion or upregulation of matrix metalloproteinases?", "Is there a region where antigen presentation to immune cells might be reduced, such as by downregulation of MHC class I molecules?", "Can you identify tissue that appears to rely more on glycolysis than oxidative phosphorylation, especially in low-oxygen areas?", "Does the image suggest genomic instability, such as abnormal mitotic figures or evidence of DNA repair deficiency?", "Is there evidence of increased secretion of immunosuppressive factors in the microenvironment, possibly affecting immune cell infiltration?", "Can you see abnormal growth patterns that might be influenced by hormonal changes, such as regions with hormone receptor expression?", "Is there a region where chronic inflammation appears to be associated with more aggressive abnormal tissue behavior?", "Does the image show areas where growth seems inhibited, possibly due to nutrient scarcity or metabolic stress?", "Can you observe signs of increased mutation rate, such as cellular atypia, in regions that might be under genotoxic stress?", "Is there evidence that abnormal tissue is proliferating independently of external growth signals, possibly due to constitutive activation of oncogenic pathways?", "Can you identify regions where abnormal cells seem to survive well in low-oxygen environments, suggesting activation of hypoxia-adaptive pathways or metabolic flexibility?"], "functions": ["Does the image show evidence of a process characterized by uncontrolled cell proliferation?", "Can you identify a region where tissue invasion or spread to adjacent structures is apparent?", "Is there a visible indication of neovascularization, such as newly formed blood vessels supporting abnormal tissue growth?", "Does the image contain features suggesting the presence of distant tissue colonization or spread beyond the primary site?", "Is there evidence of altered tissue architecture that could result from extracellular matrix degradation or changes in cell adhesion?", "Can you see signs of immune cell exclusion or reduced immune infiltration in a particular area?", "Does the image show abnormal tissue that may be resisting cell death or apoptosis?", "Is there a region where normal organ structure appears to be replaced or obstructed by abnormal growth?", "Can you identify areas with increased inflammatory cell presence or signs of cytokine-mediated inflammation?", "Is there visual evidence of stromal cell recruitment or fibroblast activation surrounding abnormal tissue?", "Does the image suggest a disruption of normal physiological processes, such as duct or vessel obstruction?", "Are there features that might indicate genetic instability, such as cellular pleomorphism or abnormal mitotic figures?", "Can you see evidence of altered energy metabolism, such as regions with high glucose uptake or metabolic activity?", "Is there a visible indication of aberrant signaling, such as overgrowth in response to growth factor stimulation?", "Does the image show abnormal tissue that appears to evade growth suppressors or disrupt normal cell cycle checkpoints?"]}, "no_questions": {"contexual_properties": ["Can you observe areas where the staining appears more intense, suggesting increased concentration from evaporation or addition of more reagent?", "Can you identify tissue sections with decreased staining intensity, possibly due to prolonged exposure to light, air, or improper storage?", "Can you detect changes in staining that might be related to altered pH, such as after mixing with acidic or basic substances?"], "properties": ["Can you identify a material that is colorless to pale yellow in its pure form?", "Is there a solution present that might have a pH between 2.0 and 3.5?", "Can you see evidence of a substance with a melting point in the range of 220\u2013223\u00b0C?"], "relational": ["Does the tissue section appear to be from an organ system such as the nervous, digestive, respiratory, or reproductive system, with nuclear features highlighted?", "Is there a visual indication that another stain, such as eosin, periodic acid-Schiff, or Masson's trichrome, has been used alongside the nuclear stain?", "Are there regions in the tissue section where nuclei or chromatin are more intensely stained than the surrounding cytoplasm?"], "contexual_behavior": ["Can you observe enhanced nuclear contrast that might result from antigen retrieval procedures restoring chromatin structure?", "Does the image display staining variability in areas with high lipid content, such as uneven or patchy nuclear coloration?", "Are there tissue regions where nuclei are absent or unstained, potentially due to excessive autolysis?"], "functions": ["Can you see nuclear highlighting that aids in the identification of structural organization within the tissue?", "Is there a contrast between nuclear features and other cellular or extracellular components, suggesting the use of a counterstain?", "Is there visual evidence of a staining agent that enables differentiation of cellular elements in a pathological context?"]}}, "negative for er and her2 (triple negative)": {"yes_questions": {"contexual_properties": ["Does the image show a mass that appears to have changed in size, possibly due to tumor progression or response to therapy?", "Is there a structure that looks larger than surrounding tissues, suggesting loss of growth regulation or increased cell proliferation?", "Can you identify an area that appears to have shrunk, which might indicate a response to chemotherapy or targeted treatment?", "Does the image reveal a mass with variable texture, possibly due to fibrosis, necrosis, or effects of treatment?", "Is there a region with altered color that could be explained by hemorrhage, necrosis, or changes in vascularity?", "Can you see an area with increased cellular density, consistent with rapid growth or a high mitotic index?", "Does the image contain regions of necrosis, which might result from ischemia or cytotoxic therapy?", "Is there evidence of heterogeneity within a mass, suggesting genetic diversity or adaptation to the microenvironment?", "Can you identify calcifications that may have formed during chronic necrosis or after therapy?", "Does the image show numerous mitotic figures, indicating high proliferative activity?", "Is there a region where nuclear morphology appears altered, possibly due to malignant progression or genotoxic stress?", "Can you see cystic changes within a mass, which might be due to central necrosis or degeneration?", "Is there evidence of increased vascularity, such as prominent blood vessels, suggesting angiogenesis to support tumor growth?", "Does the image show a mass with infiltrative borders, indicating invasive properties or tissue degradation?", "Are there visible changes in the extracellular matrix, possibly due to invasion or remodeling of the tumor microenvironment?", "Can you identify areas of hemorrhage that might result from vessel rupture or rapid tumor growth?", "Does the image reveal increased expression of proliferation markers, consistent with active growth or a high mitotic rate?", "Is there evidence of altered cell adhesion, such as loss of epithelial characteristics or features of epithelial-mesenchymal transition?", "Can you see changes in stromal content, possibly due to remodeling by cancer-associated fibroblasts?", "Is there increased infiltration of immune cells in response to tumor antigens or immunogenic cell death?"], "properties": ["Does the image show a tumor that lacks detectable estrogen receptor expression?", "Is there evidence of a neoplasm with less than 1% of cells positive for progesterone receptor?", "Can you identify a lesion where HER2 protein expression is absent or scored as 0 or 1+ by immunohistochemistry?", "Does the tumor in the image appear to be of high histological grade, such as grade 3?", "Is there a region with an elevated proliferation index, for example, high Ki-67 staining?", "Can you see features consistent with a basal-like molecular subtype, such as positivity for cytokeratin 5/6 or EGFR?", "Does the tumor appear larger than 2 cm in size?", "Are there signs of increased mitotic activity, such as frequent mitotic figures?", "Is there evidence of high nuclear pleomorphism and prominent nucleoli in the tumor cells?", "Does the image show a neoplasm with a high nuclear grade, indicating marked atypia?", "Are basal markers like cytokeratin 5/6 or EGFR frequently expressed in the tumor cells?", "Can you identify features that might suggest the presence of TP53 or BRCA1 mutations in the tumor?", "Is there evidence of complex chromosomal aberrations, such as gains on chromosomes 1q or 8q?", "Does immunohistochemical staining reveal negativity for estrogen receptor, progesterone receptor, and HER2, but positivity for basal cytokeratins and EGFR?"], "relational": ["Does the image show a malignant epithelial tissue within the breast?", "Is there a tumor mass present in the breast ducts or lobular units?", "Can you identify a neoplasm that fits the subclassification of triple negative breast cancer?", "Are there tumor cell nuclei or cell membranes visible that could be evaluated for receptor status?", "Does the image contain a lesion involving the glandular or ductal regions of the breast?", "Is there evidence of a tumor infiltrating or abutting the breast stroma, adipose tissue, or skin?", "Can you see histological features consistent with invasive ductal carcinoma or medullary carcinoma?", "Is there a specimen that appears to be from a core needle biopsy or an excisional sample of a breast mass?", "Are there any regions suggestive of lymphatic invasion or involvement of axillary lymph nodes?", "Does the image show areas where biomarkers such as progesterone receptor or Ki-67 might be assessed alongside ER and HER2?"], "contexual_behavior": ["Is there evidence of cells that change their function in response to chemotherapy or develop resistance to drugs?", "Can you identify a tumor that would likely show resistance to hormone therapy due to the absence of estrogen receptor and HER2 pathways?", "Does the image suggest increased cell proliferation in regions that might be hypoxic, possibly due to hypoxia-inducible factor activation?", "Is there a tumor exhibiting altered metastatic behavior in the presence of inflammation or inflammatory mediators?", "Can you see features suggesting immune evasion that might change during immunotherapy or when immune checkpoint pathways are inhibited?", "Does the tumor display signs of impaired DNA repair, such as after radiation exposure, possibly due to defects in homologous recombination?", "Is there evidence of increased invasiveness in response to growth factors like EGF or TGF-\u03b2?", "Can you observe reduced apoptotic response under oxidative stress, potentially due to upregulation of anti-apoptotic pathways?", "Does the image show increased angiogenic activity, such as enhanced blood vessel formation during tumor progression?", "Is there a tumor that appears to have shifted its metabolic activity to glycolysis in a nutrient-deprived environment?", "Can you identify a tumor that would not respond to therapies targeting estrogen receptor or HER2 due to their absence?", "Is there evidence of increased cell cycle progression, possibly following the loss of tumor suppressors such as p53 or RB?", "Does the image suggest improved immune recognition, such as enhanced T cell infiltration, after checkpoint inhibitor treatment?", "Can you see signs of reduced sensitivity to DNA-damaging agents, possibly due to upregulated or alternative DNA repair mechanisms?", "Is there evidence of increased cell migration in the presence of inflammatory cytokines like IL-6 or TNF-\u03b1?"], "functions": ["Does the image show a tumor with features suggesting high proliferation or invasiveness?", "Is there evidence of rapid tumor growth or early progression in the depicted tissue?", "Can you identify a neoplastic area that appears to lack hormone or HER2 receptor expression?", "Does the image suggest uncontrolled cancer cell proliferation without signs of hormone or HER2-mediated growth regulation?", "Is there a tumor that might be resistant to hormone-based therapies due to the absence of specific receptors?", "Are there visual cues indicating dysregulation of DNA repair, cell cycle, or immune evasion mechanisms?", "Does the tumor exhibit characteristics associated with a high risk of distant organ spread or metastasis?", "Can you observe increased infiltration of immune cells or features suggestive of immune checkpoint expression within the tumor microenvironment?", "Is there evidence of disrupted signaling pathways, possibly indicating reliance on alternative growth signals?", "Does the tumor display features linked to greater aggressiveness or a poorer clinical prognosis compared to other subtypes?", "Are there indications that the tumor may be more sensitive to chemotherapy due to a high proliferation rate and lack of targeted therapy options?", "Can you distinguish a neoplasm with a distinct molecular profile or unique therapeutic vulnerabilities compared to hormone-dependent subtypes?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image contain a suspicious mass within the adrenal gland, colon, thyroid, or lung?", "Is there a visible association between a mass and regional lymph nodes or lymphatic capillaries?", "Can you see evidence of tissue invasion, fibrosis, or a stromal reaction near a lesion?"], "contexual_behavior": [], "functions": ["Does the image show signs of inflammation or changes in the local tissue environment, such as matrix remodeling or altered stromal cell behavior?", "Is there evidence of a pro-tumorigenic inflammatory response, such as the presence of recruited immune cells or cytokine-mediated changes in the tissue?", "Is there visual evidence of altered cellular signaling, such as abnormal growth patterns or loss of normal tissue boundaries?"]}}, "apocrine dcis": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a process occurring within the ductal system of the mammary gland?", "Can you identify a non-invasive neoplastic lesion confined to the ducts of the breast?", "Is there a structure present that affects the mammary or lactiferous ducts?", "Does the image contain epithelial tissue with features of apocrine cells?", "Can you see a lesion surrounded by breast stroma or adipose tissue?", "Is there evidence of a process involving ductal epithelium within glandular tissue of the breast?", "Does the image show a region where apocrine epithelial cells and myoepithelial cells are present together?", "Can you identify a lesion arising within the breast ductal system but not invading surrounding tissue?", "Is there a structure adjacent to lobules, connective tissue, or blood vessels that appears abnormal?", "Does the image include a process limited to ductal structures within the mammary gland?"], "contexual_behavior": ["Does the image show a lesion with increased cell proliferation that could be associated with elevated growth factor signaling?", "Is there evidence of a structure that might exhibit reduced responsiveness to hormonal signals, such as low estrogen or progesterone receptor expression?", "Can you identify an area where apoptotic regulation appears impaired, possibly due to overexpression of anti-apoptotic proteins?", "Does the image contain cells with prominent apocrine-type protein secretion or features of active secretory phases?", "Is there a region where growth rate appears altered, potentially in response to endocrine therapy?", "Can you see features suggesting enhanced invasive potential, such as those that might occur under hypoxic conditions?", "Is there evidence of decreased differentiation capacity, possibly indicating tumor progression?", "Does the image show reduced immune evasion, which could be due to increased immune surveillance or inhibited immune checkpoint pathways?", "Can you identify areas with increased metabolic activity, potentially in response to growth factors?", "Is there a region where epithelial barrier function appears compromised, such as loss of cell junction integrity?", "Does the image show changes in secretory behavior that might be linked to inflammation or cytokine activity?", "Are there features suggestive of impaired DNA repair, such as those that might occur under genotoxic stress?", "Can you identify areas where resistance to apoptosis is increased, possibly in the context of chemotherapy exposure?", "Is there evidence of decreased hormone receptor expression, potentially associated with disease progression and dedifferentiation?", "Does the image reveal changes in cellular signaling that could be attributed to alterations in the extracellular matrix or stromal interactions?"], "functions": ["Does the image show a region within breast tissue where cells are proliferating in place without invading surrounding structures?", "Can you identify an area with cells displaying cytological atypia, such as enlarged nuclei or abnormal shapes?", "Is there evidence of local progression within a ductal structure, such as expansion or extension along the duct?", "Does the image reveal abnormal proliferation of ductal epithelial cells, possibly with loss of their usual alignment or polarity?", "Can you see ducts that are distended or filled with atypical cells, leading to distortion of normal breast architecture?", "Is there a visible alteration of the basement membrane or signs of immune cell infiltration around affected ducts?", "Does the image contain regions with a high number of mitotic figures, indicating increased proliferative activity?", "Can you identify areas with abnormal secretion, such as the presence of eosinophilic granular cytoplasm or apocrine secretory material within ducts?", "Is there evidence of local inflammation, such as accumulation of lymphocytes or macrophages near certain ducts?", "Does the image suggest dysregulated cell growth, with unchecked proliferation and reduced signs of apoptosis?", "Can you observe features that might indicate altered hormone responsiveness, such as regions with low expression of estrogen or progesterone receptors?", "Is there any indication of stromal remodeling or activation of fibroblasts adjacent to affected ducts?"]}, "no_questions": {"contexual_properties": ["Is there an absence of visible tubular or ovarian structures on the left of the uterus, possibly explained by an overlying mass?", "Can you identify a hemorrhagic inflammatory mass that prevents visualization of structures normally present near the left uterine region?", "Does the image show a mass that obscures anatomical features typically found adjacent to the left side of the uterus?"], "properties": ["Is there a mass in the left adnexal area that prevents visualization of typical reproductive structures?", "Is there a region in the image where a hemorrhagic inflammatory mass is present, potentially obscuring adjacent anatomical structures?", "Does the image show evidence of inflammation and hemorrhage in the adnexal region adjacent to the uterus?"], "relational": ["Can you see any disruption or involvement of ligaments such as the suspensory ligament of ovary or ovarian ligament in the region lateral to the uterus?", "Is there a region lateral to the uterus where the left fallopian tube and ovary would be expected, but are not visible due to an overlying mass?", "Is there a mass affecting the anatomical boundaries defined by the pelvic brim, lateral pelvic wall, and uterus?"], "contexual_behavior": ["Does the image show an area to the left of the uterus where anatomical structures are hidden by a mass with signs of bleeding and inflammation?", "Can you identify a region where the normal appearance of a tube and an ovary to the left of the uterus is not visible due to a hemorrhagic inflammatory process?", "Is there a mass present that prevents visualization of the left-sided adnexal structures next to the uterus?"], "functions": ["Does the image suggest structural or functional disruption of ovulation and egg transport roles on the left side?", "Does the image reveal tissue changes in the left adnexa that might interfere with follicular development or ovulation?", "Can you identify features consistent with obstruction or damage to the left fallopian tube, potentially hindering the passage of eggs toward the uterus?"]}}, "head atypical apocrine adenosis": {"yes_questions": {"contexual_properties": ["Does the image show a lesion that appears larger, possibly indicating recent hormonal changes or increased cellular proliferation?", "Is there evidence of a structure that has decreased in size, which might suggest hormonal stabilization or the effects of treatment?", "Can you identify an area where the cellular composition appears to be changing, such as increased or decreased numbers of atypical cells?", "Does the image reveal features consistent with heightened cellular dysplasia or progression toward malignancy, such as increased cellular atypia?", "Is there a region that appears more fibrotic, possibly due to stromal fibrosis or chronic inflammation?", "Can you observe cystic changes, such as fluid-filled spaces, that might result from secretion accumulation or ductal obstruction?", "Does the image show areas with increased mitotic activity, suggesting active cellular proliferation?", "Are there visible changes in color or appearance, such as areas of hemorrhage, necrosis, or increased vascularity?", "Is there a densely packed area where cellular proliferation seems to outpace stromal expansion?", "Can you identify regions with necrosis, which could be due to insufficient blood supply or rapid cellular turnover?", "Does the image show increased nuclear pleomorphism, possibly indicating progression of atypia or early malignant transformation?", "Are there calcifications present, which might result from chronic inflammation or degenerative changes?", "Can you see an accumulation of secretory material, suggesting apocrine hyperactivity or ductal obstruction?", "Is there a lesion that appears more palpable, either due to enlargement or increased fibrosis?", "Does the image show stromal changes that could be attributed to chronic irritation, fibrosis, or inflammatory processes?"], "properties": ["Is there a small lesion, less than 1 cm in size, visible in the image?", "Can you identify a structure that appears round or oval in shape?", "Does the image show a tissue area with a tan to pink coloration?", "Is there a region composed mainly of large cells with abundant, eosinophilic granular cytoplasm?", "Can you see evidence of crowded glands with some irregular arrangement?", "Is there an area where the density of glands is increased compared to surrounding tissue?", "Does the image reveal cells with mild to moderate nuclear atypia?", "Is there a region where the mitotic activity appears low?", "Can you identify glands containing secretory material within their lumens?", "Is there a tissue area showing mild to moderate fibrosis?", "Does the image show cells with a low nuclear-cytoplasmic ratio due to abundant cytoplasm?", "Can you see features suggestive of prominent apocrine differentiation?", "Is there evidence of both apocrine epithelial cells and scattered myoepithelial cells in the tissue?", "Does the image suggest the presence of immunohistochemical markers such as GCDFP-15 or androgen receptor positivity, along with preserved myoepithelial markers?"], "relational": ["Does the image show a region of the head that is part of the integumentary system?", "Is there an area involving the scalp or facial skin that appears abnormal?", "Can you identify changes in the dermis, epidermis, or subcutaneous tissue of the head?", "Does the image contain evidence of altered apocrine sweat glands in a head region?", "Are there visible structures adjacent to the affected area, such as hair follicles or sebaceous glands?", "Can you see any abnormalities near blood vessels within the skin of the head?", "Is there a region where atypical epithelial or myoepithelial cells might be present?", "Does the image show any changes in apocrine gland-rich regions of the head?", "Are apocrine gland ducts or their secretory units visibly altered in the image?", "Can you identify involvement of the epidermis, dermis, or superficial subcutaneous tissue in a head lesion?", "Is there evidence of interaction with nerve endings, lymphatic vessels, or other adnexal structures in the affected area?"], "contexual_behavior": ["Is there a glandular structure in the image that might display increased cellular proliferation when exposed to elevated levels of estrogens or androgens?", "Can you identify a region where secretory activity appears reduced in the context of local inflammation, possibly due to cytokine-mediated suppression?", "Does the image show a glandular area with impaired secretion that could be explained by decreased oxygen availability or tissue hypoxia?", "Is there evidence of increased proliferative behavior in a glandular structure that might be associated with chronic mechanical or chemical irritation?", "Can you see signs of altered glandular function that could result from exposure to substances interfering with normal hormonal signaling?", "Does the image contain a glandular region with decreased secretory output that might be consistent with a postmenopausal state?", "Is there a structure exhibiting abnormal cellular turnover, such as dysregulated proliferation or apoptosis, suggestive of neoplastic transformation?", "Can you identify a glandular area that appears more susceptible to functional impairment in the presence of oxidative stress or accumulation of reactive oxygen species?", "Does the image show a region where the secretory profile of a glandular structure appears altered in response to local infection or immune cell infiltration?", "Is there evidence of reduced regenerative capacity in a glandular region following tissue injury, possibly due to compromised cellular repair mechanisms?"], "functions": ["Does the image show a pathological lesion involving glandular tissue in the head region?", "Is there evidence of abnormal proliferation of apocrine glandular cells in the head area?", "Can you identify a region where normal glandular secretion appears disrupted or altered?", "Does the image reveal architectural distortion, inflammation, or fibrosis in tissues of the head?", "Is there a structure displaying increased cellular proliferation or atypical secretory behavior?", "Can you observe signs of increased mitotic activity or nuclear atypia within glandular structures?", "Is there evidence of abnormal glandular architecture or distortion in the head region?", "Does the image suggest disrupted regulation of apocrine gland processes, such as hyperplasia or secretory dysfunction?", "Can you see indications of a localized immune response, such as lymphocytic infiltration or chronic inflammation, in the head tissues?", "Is there visual evidence of secretory product accumulation or dysregulation in apocrine glands of the head?"]}, "no_questions": {"contexual_properties": ["Does the fluid appear protein-rich, which could result from increased endothelial permeability due to inflammation?", "Can you identify an area where the fluid appears thick or contains visible debris, suggesting chronic inflammation or high protein content?", "Is there a region where the fluid appears purulent, possibly due to neutrophil accumulation and bacterial infection?"], "properties": ["Can you see any material that might form fibrinous strands or clots?", "Does the image contain a substance that appears to have a high density or specific gravity?", "Can you identify a material that could have an elevated white blood cell count, possibly exceeding 1,000 cells/\u03bcL?"], "relational": ["Does the image display changes in serous, synovial, or mucous membranes that could indicate fluid buildup?", "Does the image show any anatomical structures, such as serous or synovial membranes, that appear altered or thickened?", "Can you see any signs of increased permeability in blood vessels or capillaries, such as fluid or cells escaping into surrounding tissues?"], "contexual_behavior": ["Can you identify an area where fluid appears more protein-rich, possibly due to widened endothelial gaps in response to infection?", "Does the image reveal accelerated fluid accumulation and leukocyte migration that could be associated with tissue injury?", "Can you observe differences in fluid appearance or composition that might reflect varying immune responses to different pathogens?"], "functions": ["Does the image show a substance that might be diluting toxins or dispersing harmful substances in inflamed tissue?", "Is there a structure that could be providing a medium for immune cell migration or chemotaxis?", "Does the image reveal a moist environment that could facilitate wound healing or support cell migration?"]}}, "adh": {"yes_questions": {"contexual_properties": ["Does the image show evidence of a state where water conservation by the body is likely increased?", "Is there a visual indication of dehydration or high plasma osmolality that would trigger a compensatory hormonal response?", "Can you identify features suggesting overhydration or low plasma osmolality, which would promote water excretion by the kidneys?", "Does the image contain signs of a condition such as SIADH or diabetes insipidus, which are associated with abnormal hormone secretion?", "Is there evidence of a pituitary disorder that could affect the release of a hormone involved in water balance?", "Can you see indications of genetic or hereditary disorders that might alter the molecular structure of a hormone regulating water retention?", "Does the image suggest metabolic or liver dysfunction that could influence the degradation rate of a water-regulating hormone?", "Is there a visual cue for physical or emotional stress that could activate the hypothalamic-pituitary axis and increase hormone release?", "Can you identify features consistent with heart failure, where a compensatory hormonal response to reduced blood volume may be present?", "Does the image show signs of posterior pituitary damage, which could result in decreased secretion of a hormone important for water balance?", "Is there evidence of alcohol intake or its effects, which might inhibit the secretion of a hormone from the posterior pituitary?", "Can you see indications that the subject is asleep, a state during which urine production is typically reduced due to hormonal regulation?", "Does the image suggest renal resistance or impaired secretion, as seen in diabetes insipidus, affecting water homeostasis?", "Is there any visual evidence of improper storage or metabolic disorder that could destabilize a hormone in plasma?"], "properties": [], "relational": ["Does the image show any structures that are part of the endocrine system?", "Can you identify an organ that produces hormones released by the posterior pituitary gland?", "Is there a visible structure that regulates hormone secretion in the body?", "Does the image contain the hypothalamus or the pituitary gland?", "Can you see anatomical features involved in the release of hormones from the posterior pituitary?", "Is there a structure that targets the kidneys, specifically the collecting ducts?", "Does the image show renal epithelial tissue or collecting ducts within the kidneys?", "Can you identify vascular smooth muscle that might be affected by hormonal activity?", "Is there evidence of water reabsorption occurring in the kidneys?", "Does the image include blood vessels such as capillaries or veins that could transport hormones through the bloodstream?", "Are there structures present that could function as osmoreceptors in the hypothalamus?", "Can you see blood vessels that might contain baroreceptors involved in regulating hormone release?"], "contexual_behavior": [], "functions": ["Is there evidence of a process that regulates water retention and fluid balance in the body?", "Can you identify a mechanism that increases water reabsorption in the kidneys, leading to reduced water loss in urine?", "Does the image show structures, such as collecting ducts, where water reabsorption is promoted to concentrate urine?", "Is there a feature indicating increased permeability of renal collecting ducts to water, resulting in less dilute urine?", "Can you observe any indication of a process that helps maintain blood pressure by increasing blood volume through water retention?", "Is there evidence of fluid retention due to increased renal reabsorption, leading to reduced fluid excretion?", "Does the image suggest a response to elevated blood osmolality that would result in greater water reabsorption and osmotic balance?", "Can you identify renal tubules where water reabsorption is facilitated by the insertion of aquaporins in collecting duct cells?", "Is there a process visible that contributes to homeostasis by regulating body water content, osmotic balance, or blood pressure?", "Does the image suggest any interaction between mechanisms responsible for fluid and electrolyte regulation, such as those involving aldosterone or angiotensin II?"]}, "no_questions": {"contexual_properties": ["Is there visible thickening of the ureteral walls that could indicate ongoing fibrosis or chronic inflammation?", "Are there any calcifications present along the ureter, which could be associated with chronic inflammation or infection?", "Is there a visible change in tissue composition where normal smooth muscle seems replaced by fibrous tissue in the ureter?"], "properties": ["Does the image show narrowing at the pelvic segment of both ureters near the bladder?", "Can you see signs of significant luminal obstruction, with more than 50% reduction in the diameter of both ureters?", "Is there segmental narrowing of both pelvic ureters with proximal dilation visible on the image?"], "relational": ["Does the image reveal any alterations in the walls of the paired pelvic conduits that may impact urine flow to the bladder?", "Are there signs of lymphatic involvement near the external or internal iliac lymph nodes adjacent to the pelvic portions of the urinary pathways?", "Does the image show any abnormalities affecting both lower segments of the conduits that connect the kidneys to the bladder within the pelvic region?"], "contexual_behavior": [], "functions": ["Is there evidence of structures or changes that could affect blood pressure regulation through altered renal perfusion?", "Does the image suggest accumulation of metabolic waste or impaired excretion from the kidneys?", "Are there visual cues indicating possible renal dysfunction or reduced filtration capacity?"]}}, "luminal": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a tubular or hollow appearance?", "Can you identify a region whose diameter or length varies depending on the organ it belongs to?", "Is there a surface area that appears extensive, possibly due to the presence of villi or microvilli?", "Does the image contain a cavity whose volume could range from very small to several liters depending on its anatomical context?", "Can you see a region where the pH might be acidic, neutral, or alkaline depending on the organ?", "Is there evidence of contents such as water, electrolytes, mucus, or enzymes within a hollow space?", "Does the lining of a visible cavity appear pale pink to reddish, suggesting vascularization?", "Can you observe a surface that is smooth or folded, possibly with microvilli or cilia?", "Is there a region likely to be at or near core body temperature?", "Does the fluid within a visible cavity appear to have a high water content?", "Can you identify a space where the concentration of electrolytes such as sodium, potassium, chloride, or bicarbonate might be significant?", "Are there cells lining a surface that resemble epithelial, goblet, or ciliated cells?", "Can you see evidence of mucus that could serve to protect or lubricate a lining?", "Is there a region where the oxygen level might be lower than in blood, possibly indicating hypoxic conditions?"], "relational": ["Does the image show an internal open space within an organ such as a blood vessel, intestine, or airway?", "Can you identify a region that is part of the cardiovascular, gastrointestinal, respiratory, or urinary system and contains an inner compartment?", "Is there a visible boundary formed by epithelial tissue, such as endothelium or mucosa, lining an internal space?", "Does the image include an organ like the stomach, trachea, bladder, or intestine with a distinct inner surface?", "Can you distinguish between the inner open compartment and the surrounding region of a tubular structure?", "Are there cells lining an internal surface that resemble epithelial cells, such as enterocytes, goblet cells, or endothelial cells?", "Does the image show a space containing fluids, gases, blood, chyme, or cellular debris within an organ?", "Can you identify a cavity that could represent the lumen of the gastrointestinal tract, a blood vessel, or a bronchus?", "Is there a region directly lined by an epithelial layer that acts as a barrier to the internal environment?", "Does the image display a pathway, such as the gastrointestinal tract, a blood vessel, a ureter, or a bronchus, defined by its internal open space?"], "contexual_behavior": ["Does the image show evidence of increased absorption in the digestive tract that might occur after eating or in response to hormones like secretin?", "Is there a visible reduction in secretion within the gastrointestinal tract that could suggest inflammation or cytokine imbalance?", "Can you identify signs of impaired nutrient transport that might be associated with mucosal injury or malabsorption syndromes?", "Does the image reveal changes in the digestive tract that could indicate altered pH affecting enzyme activity, such as variations in gastric acid or bicarbonate secretion?", "Is there any indication of weakened barrier function in the digestive lining, possibly due to infection or inflammation disrupting tight junctions?", "Can you observe an increase in fluid volume within the intestinal space that might result from an osmotic load drawing water into the lumen?", "Does the image suggest slowed clearance of toxins, as might be seen in conditions like liver failure or impaired peristalsis?", "Is there evidence of heightened immune defense in the digestive tract, such as increased presence of immune cells or secreted immunoglobulins, possibly due to pathogen exposure?", "Can you detect decreased motility in the gastrointestinal tract that could be related to the effects of medications like opioids or anticholinergics?", "Does the image display features consistent with accelerated transit of intestinal contents, as might occur during diarrhea?", "Is there any indication that the environment within the digestive tract is less favorable for beneficial microbiota, potentially due to antibiotic use or dietary changes?", "Can you see signs of decreased electrolyte absorption in the digestive lining, possibly resulting from chronic illness or transporter dysfunction?", "Is there visible evidence of increased mucus secretion in response to irritants such as toxins, allergens, or infections?", "Does the image suggest heightened antigen presentation or increased immune cell activity in the digestive tract, as might occur during allergic reactions?", "Can you identify signs of slowed enzymatic breakdown of food in the digestive tract, potentially due to reduced secretion of digestive enzymes as seen in pancreatic insufficiency?"], "functions": ["Does the image show a structure that acts as a conduit for transporting substances within an organ?", "Can you identify a region that provides a smooth, mucosal-lined surface to facilitate the movement of materials?", "Is there an area where increased surface area suggests a role in absorption or epithelial contact?", "Does the image contain a compartment where glands or epithelial cells might release enzymes or mucus?", "Can you see a surface that could enable nutrient uptake by allowing molecules to cross into underlying tissues?", "Is there a space that appears to house digestive enzymes or facilitate the mixing of ingested materials?", "Does the image show a region that might serve as a physical barrier, protecting underlying tissues and supporting mucosal defense?", "Can you identify an area where the passage of fluids or gases could be regulated by sphincters, valves, or selective permeability?", "Is there a surface that could contribute to immune defense by hosting immune cells or producing antimicrobial peptides?", "Does the image reveal a compartment that might support colonization by commensal microbes or play a role in host defense against pathogens?"]}, "no_questions": {"contexual_properties": ["Is there an indication that weight gain has plateaued, possibly due to illness or inadequate nutrition?", "Does anyone in the image appear to have an increased heart rate, possibly due to fever, dehydration, or infection?", "Is there an individual who appears to be affected by hypothermia, such as showing signs of cold exposure or prematurity?"], "properties": ["Is there an individual whose length appears to be approximately 50 centimeters?", "Is there a subject whose daily urine output would be approximately 1 to 3 milliliters per kilogram per hour?", "Is there a subject whose bilirubin level at birth is less than 5 milligrams per deciliter, possibly rising to 12 mg/dL in the first week?"], "relational": ["Are there features indicating ongoing structural changes in organ systems like the nervous or immune system?", "Can you identify a figure with body parts including a head, trunk, limbs, hands, and feet?", "Does the image display a head with soft spots or gaps between the cranial bones, such as an anterior or posterior fontanelle?"], "contexual_behavior": ["Is there a person whose lung function could improve after treatment for respiratory distress, such as surfactant or oxygen therapy?", "Is there a subject whose neurological function could be impaired by hypoxia, especially during birth complications or respiratory failure?", "Does the image depict someone whose feeding behavior might change during illness or teething due to decreased appetite or oral discomfort?"], "functions": ["Can you identify someone with immature organ systems, such as underdeveloped immunity or kidneys?", "Does the image show an individual with immature alveolar structures in the lungs?", "Can you identify someone whose cardiovascular system is adapting postnatally, such as with closure of fetal shunts or higher heart rates?"]}}, "atypical apocrine adenosis": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a small lesion, less than 1 cm in size, visible in the image?", "Can you identify a structure with an irregular or lobulated shape?", "Does the image show a glandular proliferation with a sclerosing architectural pattern?", "Is there a proliferation of cells with abundant eosinophilic granular cytoplasm?", "Can you see a lesion composed mainly of apocrine epithelial cells surrounded by myoepithelial cell layers?", "Does the tissue display a pink to eosinophilic appearance under the microscope?", "Is there evidence of low to intermediate nuclear grade in the epithelial cells present?", "Can you identify an area with mild to moderate cellular atypia?", "Does the lesion exhibit low mitotic activity and a low Ki-67 proliferation index?", "Is necrosis absent in the area of interest?", "Can you see a fibrous or sclerotic stroma surrounding the glandular structures?", "Are calcifications rare or infrequently present within the lesion?", "Does the immunohistochemical staining show positivity for GCDFP-15 or androgen receptor, and negativity for estrogen and progesterone receptors?"], "relational": ["Does the image show a lesion arising from glandular epithelial tissue within the breast?", "Can you identify a proliferative lesion associated with the mammary gland system?", "Is there a structure located in the peripheral or subareolar region of the breast?", "Does the image contain a lesion involving terminal ducts or lobules?", "Can you see cellular components such as apocrine epithelial cells or myoepithelial cells within a breast lesion?", "Is there evidence of a lesion adjacent to terminal duct lobular units or surrounded by breast stroma?", "Does the image show a proliferative lesion with cytologic atypia within otherwise normal breast tissue?", "Can you identify a lesion structurally related to sclerosing adenosis or apocrine ductal hyperplasia?", "Is there a lesion supported by fibrous stroma or a collagenous matrix?", "Does the image contain a lesion encompassed by a breast lobe or mammary gland?"], "contexual_behavior": ["Does the image show a region with increased cellular proliferation that could be associated with hormonal stimulation or proliferative breast disease?", "Is there evidence of impaired glandular secretion in areas where apocrine glands display architectural distortion or cellular atypia?", "Can you identify structures that might exhibit altered hormone responsiveness, such as changes in estrogen or androgen receptor expression?", "Does the image contain tissue remodeling that could be linked to chronic inflammation or fibrocystic changes?", "Is there a region where cytologic atypia or the presence of other high-risk breast lesions might suggest an increased risk of malignant transformation?", "Can you see areas where normal apocrine function appears reduced, possibly due to hormonal changes like menopause or endocrine therapy?", "Is there evidence of decreased apoptotic activity, such as increased cellular survival signals or anti-apoptotic molecular alterations?", "Does the image show altered secretory behavior in glandular structures that could be influenced by cytokine-mediated changes during inflammation?", "Are there regions where epithelial barrier function may be compromised, indicated by disruption of cell junctions or loss of epithelial integrity?", "Can you identify areas with increased resistance to cell death, potentially due to upregulation of survival pathways or impaired apoptotic mechanisms?"], "functions": ["Does the image show areas within breast lobules where the epithelial cells display abnormal nuclear features or increased mitotic activity?", "Can you identify regions in the breast tissue where there is an expansion of lobular units with disorganized architecture?", "Is there evidence of increased numbers of apocrine cells leading to altered or abnormal glandular secretion profiles?", "Does the image contain breast tissue where typical epithelial cells appear to be replaced by cells with atypical apocrine features?", "Can you see signs of stromal changes or mild inflammation surrounding certain lobules in the breast tissue?", "Is there visual evidence of architectural distortion or disorganization within the lobular structures of the breast?", "Does the image reveal areas where the normal ductal or lobular architecture appears distorted or dominated by a single cell type?", "Can you detect regions where regular glandular activity seems impaired due to the presence of atypical cellular features?", "Is there a visible proliferation of cells within breast lobules that suggests hyperplasia of apocrine cells?", "Does the image show any signs of tissue remodeling, such as expansion or disorganization of lobular structures?"]}, "no_questions": {"contexual_properties": ["Does the image show an increased presence of cells typically associated with severe hepatic damage or chronic disease states?", "Do any cells exhibit increased marker expression, such as CK19 or EpCAM, in areas of liver injury?", "Can you identify small cells that appear more numerous in regions where hepatocyte proliferation might be impaired?"], "properties": ["Do you see a cell that is likely diploid, with a 2n chromosomal content?", "Can you identify a cell where water constitutes about 70 to 80% of its total mass?", "Do you observe a cell with relatively high RNA content, approximately 10 to 20 picograms per cell?"], "relational": ["Are there cells near branches of the portal vein or hepatic artery?", "Can you identify cells related to hepatocytes, cholangiocytes, or hepatic progenitor cells in the image?", "Does the image show cells situated within the hepatic lobule or portal tract compartments?"], "contexual_behavior": ["Is there abnormal proliferation of a cell population in the presence of carcinogens, potentially contributing to tumorigenesis?", "Is there impaired tissue repair after viral hepatitis, possibly due to chronic inflammation affecting progenitor cell function?", "Does the image suggest increased activity of a progenitor population in response to metabolic stress, such as steatosis or insulin resistance?"], "functions": ["Does the image contain cells undergoing lineage commitment, giving rise to both hepatocytes and biliary epithelial cells?", "Is there a visible expansion or activation of cells in response to chronic liver damage?", "Does the image show cells contributing to hepatic function by generating new functional liver cells or participating in tissue remodeling during liver disease?"]}}, "cancer": {"yes_questions": {"contexual_properties": ["Is there a region in the image that appears to be increasing in size due to rapid cell proliferation?", "Can you identify an area that seems to have shrunk, possibly indicating a response to therapy or increased cell death?", "Does the image show a structure with color changes that might reflect altered blood supply, necrosis, or bleeding?", "Is there evidence of increased vascularization, suggesting the formation of new blood vessels to support tissue growth?", "Can you see central regions within a mass that appear necrotic, possibly due to insufficient blood supply?", "Does any area appear denser, which could be due to increased cellularity or extracellular matrix deposition?", "Is there visible loss of cellular uniformity, such as pleomorphism or atypical cell shapes?", "Can you detect regions with heightened cell proliferation, possibly due to activation of oncogenic pathways?", "Are there areas within a mass that show calcifications, which may result from mineralization in necrotic tissue?", "Does the image reveal invasive features, such as tissue extending into or degrading surrounding structures?", "Is there abnormal tissue composition where normal architecture is replaced by malignant cells or altered stroma?", "Can you identify regions with increased metabolic activity, potentially reflecting upregulated glycolysis?", "Does the structure appear heterogeneous, with areas showing different genetic or phenotypic characteristics?", "Are there surface irregularities or ulcerations visible, suggesting changes in the extracellular matrix or epithelial breakdown?", "Can you see cystic regions or fluid-filled spaces within a mass, possibly due to liquefactive necrosis?", "Are there increased mitotic figures, indicating elevated rates of cell division?", "Is there evidence of surface ulceration where the overlying epithelium or mucosa is disrupted?", "Does the image suggest changes in molecular marker expression, such as altered protein or gene levels?", "Are there regions that appear more rigid, possibly due to fibrosis or a desmoplastic reaction in the stroma?", "Can you identify hemorrhagic areas within a mass, which may result from ruptured or fragile blood vessels?"], "properties": ["Is there a mass in the image that measures between 1 and 5 centimeters in diameter?", "Can you identify a region where the cells appear to be proliferating at a rate higher than normal tissue?", "Does the image show tissue composed of a mix of malignant, stromal, immune, and endothelial cells?", "Is there an area where the proportion of dividing cells seems elevated, possibly exceeding 10%?", "Can you see cells with a nuclear-to-cytoplasmic ratio greater than 1:1?", "Is there evidence of cells with increased or abnormal DNA content compared to typical diploid cells?", "Are there visible signs of chromosomal abnormalities such as aneuploidy, translocations, deletions, or amplifications?", "Does the image contain a region where the average cell doubling time might be as short as 24 hours to several days?", "Can you identify cells with irregular shapes, prominent nucleoli, or variable sizes within the tissue?", "Is there an area that appears hyperchromatic, with increased staining intensity under microscopy?", "Does the tissue show overexpression of biomarkers such as CEA, CA-125, or PSA?", "Can you see evidence of increased vascular density, possibly due to angiogenesis?", "Is there a region that might exhibit high metabolic activity, such as increased glucose uptake or glycolysis?", "Does the image suggest areas of low oxygen concentration, indicating possible hypoxic regions?", "Is there evidence that the microenvironment pH is acidic, possibly between 6.5 and 6.9?", "Can you identify cells with altered protein expression, such as upregulation of oncogenes or downregulation of tumor suppressors?", "Does the tissue appear stiffer than normal, suggesting increased extracellular matrix deposition?", "Is there an indication that the water content of the tissue is around 70-80%?", "Can you see evidence of elevated lipid content in the cells, reflecting altered membrane synthesis or metabolism?", "Is there a region where the genetic mutation burden appears high, with numerous somatic mutations present?"], "relational": ["Does the image show abnormal growth originating from epithelial, connective, muscle, or nervous tissue?", "Can you identify a lesion affecting organs such as the lung, liver, breast, colon, or prostate?", "Is there evidence of altered epithelial cells, lymphocytes, melanocytes, or glial cells within the image?", "Does the image reveal involvement of lymph nodes, bones, brain, liver, or lungs by an abnormal process?", "Can you see signs of lymphatic invasion or lymph node involvement in the depicted structures?", "Is there a visible impact on the respiratory, digestive, nervous, or hematopoietic systems?", "Does the image show abnormal structures interacting with blood vessels, lymphatic vessels, or body cavities?", "Can you identify disruption or invasion of anatomical barriers such as the basement membrane, blood-brain barrier, or extracellular matrix?", "Is there evidence of abnormal tissue in organs commonly affected by metastatic processes, such as the liver, lungs, bones, or brain?", "Does the image display features suggestive of new blood vessel formation, vascular invasion, or spread through the bloodstream?"], "contexual_behavior": ["Does the image show evidence of abnormal cell proliferation that could be associated with activation of pathways like MAPK or PI3K/AKT?", "Is there a region where cells appear resistant to programmed cell death, potentially due to upregulation of anti-apoptotic proteins or loss of tumor suppressor function?", "Can you identify features suggesting invasion into surrounding tissues, such as changes consistent with epithelial-mesenchymal transition or increased matrix degradation?", "Is there visual evidence of reduced sensitivity to chemotherapy, such as regions with high expression of drug efflux pumps or signs of enhanced DNA repair?", "Does the image display increased formation of new blood vessels, possibly in response to hypoxic conditions and secretion of pro-angiogenic factors?", "Are there indications of suppressed immune response, such as overexpression of immune checkpoint molecules or presence of regulatory T cells?", "Can you observe metabolic changes consistent with increased glycolysis and lactate production, especially under hypoxic conditions?", "Is there evidence of reduced growth or cell density following targeted therapy, suggesting inhibition of oncogenic drivers or lack of adaptive resistance?", "Are there features indicating increased metastatic potential, such as cell motility or invasion associated with inflammation and cytokine activity in the microenvironment?", "Does the image suggest effective immune surveillance, such as visible immune effector cell activity or presentation of tumor antigens?", "Is there evidence of increased mutation rate, such as cellular atypia or features consistent with genotoxic stress and deficient DNA repair?", "Can you identify areas where cell proliferation is reduced and cell cycle arrest is apparent, possibly due to nutrient deprivation and activation of energy-sensing pathways?", "Are there signs of increased drug efflux activity, such as upregulation of ATP-binding cassette transporters in response to treatment?", "Does the image show alterations in cellular signaling or morphology that could be linked to changes in hormone receptor activity?", "Is there a reduction in cell proliferation or density following radiation exposure, potentially due to activation of DNA damage checkpoints?", "Can you observe adaptations for survival in a low pH environment, such as upregulation of acid-resistant enzymes or metabolic changes?", "Are there signs of increased secretion of growth factors, such as enhanced autocrine or paracrine signaling during tumor progression?", "Does the image indicate reduced invasiveness after immunotherapy, possibly due to immune-mediated cytotoxicity?", "Are there features suggesting behavioral adaptation in response to anti-angiogenic drugs, such as activation of alternative angiogenic pathways or increased invasiveness?", "Can you detect increased immune evasion mechanisms in the presence of checkpoint inhibitors, such as upregulation of alternative immune checkpoints or recruitment of immunosuppressive cells?"], "functions": ["Does the image show a region where cells appear to be proliferating uncontrollably or invading surrounding tissues?", "Is there evidence of tissue architecture being distorted or normal cells being replaced by abnormal ones?", "Can you identify an area where organ function might be impaired due to infiltration by abnormal cells?", "Does the image reveal signs of new blood vessel formation that could be stimulated by factors like VEGF?", "Is there a region where the extracellular matrix appears degraded or where cells seem to have increased motility?", "Can you see features suggesting that abnormal cells have spread to distant organs, possibly through the circulation?", "Does the image show clusters of cells that might be activating proliferative signaling pathways or blocking differentiation?", "Is there visual evidence of immune cell exclusion or suppression, such as regions with few immune cells or altered microenvironment?", "Can you identify areas where cells might be resisting programmed cell death, such as dense clusters lacking apoptotic features?", "Does the image display recruitment of stromal cells or remodeling of the extracellular matrix around abnormal cell clusters?", "Is there evidence of increased nutrient uptake or metabolic changes, such as densely packed cells near new blood vessels?", "Can you see signs of inflammation, such as immune cell recruitment or regions with increased cytokine production?", "Does the image suggest systemic effects, like tissue wasting or metabolic alterations, possibly due to inflammatory mediator release?", "Are there visual cues indicating genetic instability, such as cellular pleomorphism or abnormal mitotic figures?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show a region with relatively low fat content compared to the surrounding tissue?", "Can you see a structure that might contain between 4 and 18 small openings on its surface?", "Is there an area that could be composed of cell types such as keratinocytes, melanocytes, myoepithelial cells, or ductal epithelial cells?"], "relational": ["Is there a structure present that belongs to both the integumentary and reproductive systems?", "Can you identify an area supplied by branches of the internal thoracic or lateral thoracic arteries?", "Is there an object that is centrally positioned within a pigmented area on the chest?"], "contexual_behavior": [], "functions": ["Does the image show a structure that facilitates milk delivery?", "Can you identify an area that provides an accessible point for infant latch during breastfeeding?", "Is there a visible conduit for milk to pass from lactiferous ducts to an infant?"]}}, "triple-negative cancers": {"yes_questions": {"contexual_properties": ["Does the image show a mass that appears to be rapidly increasing in size, suggesting aggressive progression?", "Is there evidence of tissue necrosis or regions lacking blood supply within a tumor-like structure?", "Can you identify an area with unusually high cellular density or signs of accelerated cell proliferation?", "Does the lesion display heterogeneous appearance or color changes that might indicate necrosis or hemorrhage?", "Are there any calcifications present within a tumor, possibly as a result of prior therapy or degeneration?", "Can you observe features consistent with a high mitotic rate, such as numerous dividing cells within the mass?", "Is there visible heterogeneity in tissue composition, suggesting clonal diversity or tumor evolution?", "Does the image reveal areas with elevated proliferation markers, such as increased Ki-67 staining?", "Are there signs of invasive growth patterns or structural changes associated with genetic alterations or epithelial-mesenchymal transition?", "Can you see fibrotic regions within the tumor, possibly resulting from chronic inflammation or post-treatment effects?", "Is there evidence of increased vascularity or new blood vessel formation, indicating angiogenesis or rapid tumor expansion?", "Do you observe changes in tumor marker expression or levels that could reflect disease progression or response to therapy?", "Are there edematous regions within or around the mass, suggesting increased vascular permeability or lymphatic obstruction?", "Does the tumor contain cystic areas, possibly due to central necrosis or degeneration?", "Is there evidence of increased metabolic activity, such as high glucose uptake on PET imaging, within the lesion?", "Can you identify changes in nuclear size or shape, indicating malignant transformation or cellular atypia?", "Are there hypoxic regions within the tumor, possibly due to rapid growth outpacing vascular supply?", "Does the mass display increased stromal content or a desmoplastic response in the surrounding tissue?", "Is there abnormal extracellular matrix composition or remodeling visible within the tumor microenvironment?", "Can you detect features suggestive of genomic instability, such as variable nuclear morphology or chromosomal aberrations?"], "properties": ["Does the image show a tumor with high cellular pleomorphism or poorly differentiated morphology?", "Is there a mass present that appears larger than 2 centimeters?", "Can you identify a region with a high density of mitotic figures, suggesting rapid cell division?", "Does the image contain cells with prominent nucleoli or a high nuclear grade?", "Is there evidence of invasive ductal carcinoma with minimal glandular formation?", "Can you see a tumor area with increased cell turnover or a high proliferation rate?", "Are there visual signs of chromosomal aberrations or genomic instability, such as irregular nuclear shapes?", "Does the image suggest a complex karyotype or frequent copy number alterations in the tumor cells?", "Is there a region with notably high tumor cell density or a compact tumor mass?", "Can you identify areas with high expression of proliferation markers such as Ki-67?", "Are there indications of abnormal DNA content or aneuploidy in the tumor cells?", "Do the cells display moderate to high cytoplasmic content relative to their nuclei?", "Is there a significant proportion of necrotic tissue, possibly exceeding 30% of the tumor area?", "Can you observe moderate to high stromal content or a desmoplastic stroma surrounding the tumor?", "Does the image reveal increased vascular density or evidence of angiogenesis within the tumor?", "Is there a tumor present that would be classified as grade 3 based on its histological features?", "Are there visual cues suggesting a high mutation burden or extensive genomic alterations?", "Can you detect moderate to high infiltration of immune cells, such as tumor-infiltrating lymphocytes, within the tumor microenvironment?", "Is there evidence of elevated lipid content or visible lipid droplets in the tumor cells?", "Does the protein expression profile appear to lack estrogen receptor, progesterone receptor, and HER2, while showing features consistent with basal-like markers?"], "relational": ["Does the image show a region that could be part of the breast or axillary area?", "Is there evidence of abnormal tissue involving the breast epithelium or stromal tissue?", "Can you identify malignant epithelial cells or associated stromal and immune cells in the image?", "Is there a structure adjacent to the pectoral muscles or chest wall that appears abnormal?", "Does the image display lymphatic structures such as axillary or supraclavicular lymph nodes that appear enlarged or involved?", "Are there visible changes near blood vessels like the internal mammary artery or lateral thoracic artery?", "Can you see any indication of invasion into the skin, chest wall, or lungs?", "Is there a disruption or abnormality at anatomical boundaries such as the breast capsule, pectoral fascia, or dermis?", "Does the image suggest possible spread to larger regions such as the lungs, liver, bones, or brain?", "Are there features in the connective tissue or stromal regions that might indicate malignancy?"], "contexual_behavior": ["Does the image show a tumor that might be resistant to chemotherapy after repeated exposure to cytotoxic agents?", "Can you identify a neoplasm that could display multidrug resistance features?", "Is there evidence of increased metastatic activity or signs of tumor progression, possibly linked to epithelial-mesenchymal transition?", "Does the image contain a malignancy that would likely not respond to hormone therapy due to the absence of estrogen, progesterone, and HER2 receptors?", "Can you see a tumor that might evade immune detection during progression or under immune pressure?", "Is there a neoplastic region that could show metabolic adaptation to hypoxic conditions, such as increased glycolysis?", "Does the image reveal enhanced angiogenesis, possibly as a response to hypoxic signaling during tumor growth?", "Is there a tumor area where proliferation rate appears reduced, potentially due to cellular stress or chemotherapy exposure?", "Can you identify a malignancy that would not respond to targeted therapies aimed at hormone receptors or HER2?", "Does the image suggest increased DNA repair activity in response to radiation exposure or genotoxic stress?", "Is there evidence of altered cell signaling in response to growth factors during tumor progression or microenvironmental changes?", "Can you see features suggesting increased invasiveness or cell migration in the presence of inflammatory cytokines?", "Does the tumor appear to have decreased apoptosis, possibly due to upregulation of anti-apoptotic proteins under cellular stress?", "Is there evidence of a modified immune microenvironment, such as altered immune cell infiltration or cytokine production, potentially in the context of immunotherapy?", "Can you identify a region with increased glycolytic activity during nutrient deprivation, consistent with the Warburg effect?", "Does the image suggest reduced antigen presentation, such as downregulation of MHC class I molecules, under immune pressure?"], "functions": ["Does the image show a tumor that lacks expression of estrogen receptor, progesterone receptor, and HER2?", "Is there evidence of a neoplasm with aggressive features and limited options for targeted therapy?", "Can you identify a tumor that might evade immune detection by expressing high levels of PD-L1 or showing reduced antigen presentation?", "Does the image reveal a mass with signs of rapid cell division or high proliferative activity?", "Is there a tumor displaying features consistent with enhanced epithelial-mesenchymal transition or increased cell motility?", "Can you observe evidence of extracellular matrix degradation or features suggestive of metastatic potential?", "Is there a neoplasm that could initially respond to chemotherapy but is associated with a high risk of recurrence or poor prognosis?", "Does the image suggest mechanisms of drug resistance, such as increased DNA repair activity or reduced apoptosis?", "Can you see features indicating recruitment of immunosuppressive cells or secretion of pro-inflammatory cytokines within the tumor microenvironment?", "Is there evidence of increased blood vessel formation, possibly due to upregulation of vascular endothelial growth factor or other pro-angiogenic factors?", "Does the tumor appear to rely on alternative growth signals rather than hormone receptor pathways for progression?", "Can you identify signs of inflammation, such as immune cell infiltration or secretion of inflammatory mediators supporting tumor growth?", "Is there visual evidence of interaction between the tumor and stromal cells, such as activated fibroblasts or remodeling of the extracellular matrix?", "Does the tumor display features suggestive of genetic instability, such as high mutation rates or chromosomal abnormalities?", "Can you observe alterations in the immune landscape, such as increased regulatory T cell infiltration or changes in cytokine profiles?", "Is there evidence of dysregulated cell cycle checkpoints or inhibited programmed cell death contributing to enhanced tumor cell survival?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you deduce from the staining pattern whether the antibodies used could have a molecular weight in the range of 150 to 160 kDa?", "Does the image suggest that the staining reagents might have a shelf life of 6 to 24 months depending on storage conditions?", "Does the staining intensity in the image appear weak, moderate, or strong, suggesting variable antigen expression?"], "relational": ["Is there visualization of cellular organelles such as nuclei or mitochondria?", "Does the image show tissue from the nervous, immune, or endocrine system?", "Does the image show a tissue sample that could be from a tumor or a normal organ?"], "contexual_behavior": [], "functions": ["Can you identify features that would assist in classifying tumor origin or subtype based on tumor-specific antigen detection?", "Can you observe visualization of immune cell markers or cytokine expression patterns that would support evaluation of immune responses in the tissue?", "Does the image show labeling of pathogen-specific antigens that could indicate the presence of infectious agents?"]}}, "dcis": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion located within the mammary gland system?", "Is there an abnormality affecting the epithelial layer or basement membrane of breast ducts?", "Can you identify a structure surrounded by a basement membrane and myoepithelial layer?", "Does the image contain a lesion confined to the mammary or lactiferous ducts?", "Is there evidence of a process arising within the ductal epithelium of the breast?", "Can you see a lesion present in the central, peripheral, or subareolar regions of the breast?", "Does the image show clusters of neoplastic epithelial cells within a ductal structure?", "Is there a structure where myoepithelial cells are present around an abnormal proliferation?", "Can you identify an area where an intact basement membrane separates abnormal cells from surrounding stromal tissue?", "Does the image contain a lesion whose boundaries are defined by ductal walls or a basement membrane?", "Is there evidence of a process confined to ductal structures without involving the lobules of the breast?"], "contexual_behavior": [], "functions": ["Does the image show evidence of epithelial cell proliferation confined within a ductal structure?", "Can you identify a region where the ductal lumen appears obstructed or filled with abnormal cells?", "Is there an area where the organization of epithelial cells within a duct seems disrupted?", "Does the image contain a lesion that remains within the ductal basement membrane without invading surrounding tissue?", "Can you see features suggestive of a non-invasive growth pattern within the breast ducts?", "Is there a region where increased cellular density is visible inside a ductal structure?", "Does the image show signs of local inflammation or immune cell recruitment near a ductal lesion?", "Can you identify areas where the extracellular matrix around a duct appears altered but the basement membrane remains intact?", "Is there evidence of increased mitotic activity or abnormal cell division within a ductal region?", "Does the image reveal loss of cell polarity or abnormal arrangement of epithelial cells within a duct?", "Can you see indications of impaired apoptosis, such as accumulation of abnormal cells within a duct?", "Is there a ductal lesion that could represent an early, non-invasive stage of breast tumorigenesis?", "Does the image contain a structure that could serve as a precursor to invasive breast cancer?", "Can you identify a ductal area where stromal-epithelial interactions appear altered?", "Is there evidence of abnormal signaling or loss of growth control within a ductal epithelial population?", "Does the image show a ductal lesion with an intact basement membrane and no signs of invasion into adjacent tissue?"]}, "no_questions": {"contexual_properties": ["Is there visual evidence of dissolution, such as reduction in size or disappearance of abnormal material, possibly due to chelation therapy or restored metabolic balance?", "Are there signs of local inflammation or tissue injury associated with the abnormal material, suggesting immune activation or crystal-induced inflammation?", "Does the image show any areas that appear larger due to ongoing accumulation of calcium or urate salts?"], "properties": ["Is there evidence of masses that could weigh from milligrams to several grams?", "Can you identify any areas with a chalky, brittle, or powdery texture?", "Are there deposits that might have a hardness of approximately 3\u20135 on the Mohs scale?"], "relational": ["Can you see any clusters of cells such as macrophages, fibroblasts, lymphocytes, or giant cells near abnormal deposits?", "Can you identify firm nodules, areas of discoloration, or calcified masses that distinguish certain regions from the surrounding tissue?", "Is there evidence of larger pathological structures such as tophi, calcified plaques, or dystrophic calcifications that might contain abnormal deposits?"], "contexual_behavior": ["Are there fewer abnormal deposits in areas where dietary modification or metabolic control may have reduced serum calcium or uric acid levels?", "Is there evidence that abnormal deposits are interfering with normal enzymatic activity or disrupting the local biochemical environment in tissues?", "Are there areas of soft tissue with increased abnormal mineralization that could be associated with metabolic disorders like hyperparathyroidism or pseudogout?"], "functions": ["Can you identify areas where functional decline of tissue might be occurring?", "Can you see signs of phagocytosis or an inflammatory response in the tissue?", "Are there visual cues of cellular stress or impaired nutrient exchange in the affected region?"]}}, "negative for her2": {"yes_questions": {"contexual_properties": ["Does the image show tissue where a specific protein's expression is below the detection limit of standard assays?", "Is there evidence in the image of a biomarker whose staining intensity is weak or absent, corresponding to a score of 0 or 1+ in immunohistochemical analysis?", "Can you identify a sample where gene amplification for a particular receptor is undetectable by fluorescence in situ hybridization?", "Does the image depict tissue where a protein is not overexpressed or is absent, resulting in a negative status?", "Is there a region where the immunohistochemistry score for a certain receptor would be classified as 0 or 1+ according to clinical guidelines?", "Can you see evidence of low receptor density on cell membranes, falling below the threshold for positivity?", "Does the image suggest a status conversion, where previous overexpression or gene amplification is no longer present on follow-up testing?", "Is there an absence of signal in fluorescence in situ hybridization, with a HER2/CEP17 ratio below the amplification cutoff?", "Can you observe tissue where membranous staining for a specific receptor is absent, indicating negative membrane expression?"], "properties": ["Does the image show a tissue sample with absent or very low levels of a certain receptor protein overexpression?", "Can you identify a sample where the immunohistochemistry score for a specific marker is 0 or 1+?", "Is there evidence of weak or no membrane staining in the cells present?", "Does the image contain a sample where less than 10% of cells show positive staining for a particular protein?", "Can you see a case where the gene copy number for a specific marker is less than 6 signals per cell?", "Is there a tissue sample where the fluorescence in situ hybridization ratio for a certain gene is below 2.0?", "Does the image show a sample with a HER2/CEP17 ratio less than 2.0?", "Is there a region where the staining intensity is absent or only faint and incomplete along the cell membrane?", "Can you identify a sample with low mRNA expression of a specific gene, below the diagnostic threshold?", "Does the image show a case that meets the diagnostic criteria for negativity based on IHC \u22641+ or FISH ratio <2.0?"], "relational": ["Does the image show a tissue sample from the breast, stomach, or esophagus being evaluated for a specific biomarker?", "Can you identify ductal or glandular epithelial structures that are typically assessed in biomarker testing?", "Is there a tumor mass present in the image that could be relevant for evaluating a receptor status?", "Does the image contain epithelial tumor cells or carcinoma cells that might be assessed for receptor expression?", "Is there a lesion or tumor in the breast, stomach, or esophagus that could be the focus of biomarker analysis?", "Can you see evidence of other biomarkers such as estrogen receptor, progesterone receptor, or EGFR in the tissue sample?", "Does the image include a breast lesion, gastric tumor, or lymph node that might be sampled for receptor status?", "Is there a tumor located in the breast, stomach, or esophagus that could be tested for a specific protein's absence?", "Are there visible cell membranes, tumor nests, or glandular structures that would be examined for receptor expression?", "Can you observe features such as cellular morphology, tissue architecture, or membranous staining patterns that are important for interpreting receptor negativity?"], "contexual_behavior": ["Is there evidence in the image of a tumor that would be less responsive to therapies targeting HER2, such as trastuzumab?", "Can you identify a tumor that might exhibit slower cell proliferation due to the absence of HER2-driven signaling?", "Does the image suggest a tumor that could respond better to endocrine therapy if hormone receptors are present?", "Is there a tumor that appears less aggressive or shows fewer signs of distant metastasis, possibly due to reduced HER2 expression?", "Can you see features indicating that cell signaling pathways like PI3K/AKT or MAPK are not highly activated within the tumor?", "Does the tumor in the image appear less sensitive to certain chemotherapeutic agents that are more effective in HER2-positive cases?", "Is there any indication that immune recognition of tumor cells might be altered due to the absence of HER2-driven neoantigen expression?", "Can you identify a tumor with a lower risk of early recurrence, potentially associated with reduced HER2 expression?", "Does the tumor microenvironment show diminished angiogenesis, possibly due to reduced HER2-driven pro-angiogenic signaling?", "Is there evidence that anti-apoptotic pathways are not strongly activated in the tumor, suggesting impaired HER2-mediated cell survival?", "Does the tumor appear to have a different radiosensitivity profile compared to HER2-positive tumors?", "Can you observe metabolic features in the tumor that differ from those typically seen in HER2-driven metabolic reprogramming?", "Is there any indication that the tumor is progressing more slowly, consistent with the absence of HER2 amplification?", "Does the tumor show altered adaptation to cellular stress, possibly due to lack of HER2-mediated stress response pathways?", "Is there less disruption of adjacent normal tissues, suggesting reduced paracrine signaling from the tumor?"], "functions": ["Is there evidence in the image of a tumor that does not show overexpression of a receptor involved in signal transduction pathways?", "Can you identify a tumor that appears less reliant on growth factor signaling mediated by a specific receptor, suggesting dependence on alternative pathways?", "Does the image show a tumor with lower cell proliferation rates compared to those typically driven by mitogenic signaling from a particular receptor?", "Is there a tumor present that would likely not respond to therapies targeting a specific receptor, such as trastuzumab?", "Can you see features suggesting a tumor with a molecular profile distinct from those characterized by high expression of a certain growth receptor?", "Does the tumor in the image appear to have a lower potential for metastasis, possibly due to the absence of aggressive signaling from a particular receptor?", "Is there visual evidence of altered cell cycle regulation, indicating that cell division is less influenced by a specific signaling pathway?", "Can you identify a tumor that might interact differently with the immune system, lacking immune evasion mechanisms associated with overexpression of a certain receptor?", "Does the image suggest a tumor with reduced ability to evade apoptosis due to the absence of survival signaling from a specific receptor?", "Is there a tumor whose biological behavior and therapeutic response are influenced by the lack of a particular receptor's expression?"]}, "no_questions": {"contexual_properties": ["Are there indications of low blood glucose, especially in a neonate?", "Does the image show signs of increased birth weight or fetal overgrowth?", "Can you detect abnormal ear creases or pits, such as posterior helical pits, present at birth?"], "properties": ["Does the abdominal region display signs of wall defects, such as an omphalocele or umbilical hernia?", "Can you observe any signs of nephromegaly, such as visibly enlarged kidneys?", "Is the birth weight or overall size of the infant above the 90th percentile for age and sex?"], "relational": ["Is there visible enlargement of the tongue or other features consistent with macroglossia?", "Is there any indication of tumor risk in abdominal organs like the kidneys or liver?", "Does the image show evidence of overgrowth in soft tissue, muscle, or connective tissue?"], "contexual_behavior": ["Is there evidence of organ overgrowth affecting the liver, kidneys, or tongue during prenatal development or early childhood?", "Does the image show evidence of abnormal growth regulation during fetal development or early childhood, possibly due to disruptions in imprinted gene expression?", "Does the image show structural anomalies such as nephromegaly or adrenal cytomegaly, suggesting altered kidney or adrenal gland function during childhood?"], "functions": ["Does the image display enlargement of specific organs, such as the tongue, kidneys, or liver?", "Is there visual evidence of metabolic imbalance, such as features suggestive of neonatal hypoglycemia?", "Can you identify any signs of abnormal growth regulation, such as excessive prenatal or postnatal size?"]}}, "flat epithelial atypia": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show an abnormality within the epithelial tissue of the breast?", "Is there a region in the breast tissue where luminal epithelial cells appear altered?", "Can you identify changes occurring within the terminal duct lobular units?", "Does the image display any lesions that are part of the columnar cell lesion spectrum?", "Are there visible alterations in the terminal ducts or lobules of the breast?", "Is there evidence of changes in the epithelial layer of a terminal duct lobular unit?", "Can you see any features suggestive of columnar cell change or atypical ductal hyperplasia?", "Is there an area in the breast tissue where the stroma is adjacent to an abnormal epithelial region?", "Does the image contain structures consistent with the histological pattern of columnar cell lesions?"], "contexual_behavior": ["Does the image show an epithelial region with increased cellular proliferation that could be associated with exposure to mitogenic stimuli or hormonal imbalance?", "Can you identify an area where the normal epithelial barrier appears disrupted due to atypical architectural changes?", "Is there evidence of impaired response to hormonal changes, such as altered estrogen or progesterone signaling, in any epithelial structures present?", "Does the image contain epithelial tissue that appears at risk of progressing to higher-grade lesions, possibly in association with chronic inflammation or persistent inflammatory mediators?", "Can you observe regions where cell adhesion properties seem altered, potentially due to changes in the extracellular matrix during tissue remodeling?", "Is there an epithelial area where normal cell differentiation appears reduced, possibly indicating disruption of regulatory pathways for epithelial maturation?", "Does the image show epithelial cells with increased susceptibility to DNA damage, which could be a result of oxidative stress or compromised antioxidant defenses?", "Can you identify regions where apoptotic activity seems impaired, potentially due to oncogenic signaling or inhibition of pro-apoptotic pathways?", "Is there evidence of altered secretory function in epithelial cells, possibly influenced by growth factors that modulate cell activity?", "Does the image reveal epithelial areas with heightened proliferative activity that might be linked to increased estrogen receptor signaling during estrogen exposure?", "Can you see signs of failed cell cycle regulation in epithelial cells, which could be due to genetic mutations affecting key regulatory genes?", "Is there an epithelial region where the ability to maintain tissue homeostasis appears decreased, possibly as a result of aging and declining cellular repair mechanisms?", "Does the image show epithelial cells with enhanced resistance to cell death, particularly in hypoxic areas where survival pathways may be activated?", "Can you identify regions where repair mechanisms following tissue injury seem impaired, possibly due to deficiencies in DNA repair or cellular regeneration?", "Is there evidence that the functional behavior of epithelial cells is altered in the presence of an adjacent carcinoma, potentially due to influences from the tumor microenvironment or paracrine signaling?"], "functions": ["Does the image show a region within breast tissue where the epithelial cells appear more uniform and monotonous than usual?", "Can you identify an area in the breast epithelium with mild cytologic atypia or altered cellular organization?", "Is there evidence of abnormal proliferation or increased cellularity within the ducts of the breast tissue?", "Does the image reveal loss of normal cell polarity or architectural disturbance in the epithelial lining?", "Can you see a region where the epithelial layers appear flattened or the normal tissue architecture is distorted?", "Is there a visible area where cell-to-cell adhesion seems altered, potentially weakening the epithelial barrier?", "Does the image contain a lesion that could represent an early alteration in breast tissue, possibly preceding more advanced precancerous changes?", "Can you identify a ductal region with increased proliferation but without features of overt neoplasia?", "Is there evidence of impaired differentiation or disrupted regeneration in the breast epithelium?", "Does the image show a structure that may have altered sensitivity to hormonal regulation, such as estrogen, within the breast epithelium?", "Can you find a lesion that could be considered a non-obligate precursor to ductal carcinoma in situ?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see any anatomical features associated with the passage of the vertebral arteries or occipital vein?", "Does the image contain a structure featuring a large opening for the passage of the spinal cord?", "Can you see any foramina such as the hypoglossal canal or condylar canal in the depicted bone?"], "contexual_behavior": ["Is there a structure contributing to the foramen magnum whose integrity might be affected by congenital malformations such as basilar invagination?", "Does the image show any signs of weakened bone structure in the posterior skull that could be associated with osteomyelitis or other bone infections?", "Is there evidence of a bone in the posterior skull region where reduced mineral density could indicate compromised structural support, as seen in osteoporosis?"], "functions": ["Is there evidence of an articulation that allows for nodding movements of the head?", "Is there a structure enclosing the foramen magnum?", "Is there a bone forming the posterior and inferior walls of the cranial cavity?"]}}, "gains of chromosome 1": {"yes_questions": {"contexual_properties": ["Does the image show cells with increased DNA content suggestive of aneuploidy?", "Can you identify abnormal karyotype patterns that indicate the presence of extra chromosomal material?", "Is there evidence of structural variation, such as partial or whole-arm duplications, affecting a specific chromosome?", "Do any cells display nuclear enlargement that could be associated with chromosomal gain?", "Is there a cytogenetic abnormality visible that might be detected by karyotyping or FISH analysis?", "Can you observe mosaicism, where only a subset of cells in the tissue shows chromosomal abnormalities?", "Are there indications of increased copy number variation or genomic instability in the sample?", "Does the image contain malignant plasma cells or neuroblastoma cells with features of chromosomal gain?", "Is there a visible alteration in chromosomal banding patterns, particularly affecting a specific chromosome?", "Can you detect regional amplification, such as selective duplication of a chromosome arm like 1q?", "Are there features consistent with high-risk cancer or advanced tumor progression in the sample?", "Do you see evidence of tissue heterogeneity that could reflect mosaic chromosomal changes?", "Is there a correlation between abnormal chromosomal features and increased gene dosage or overexpression in the cells?", "Are there cytogenetic features that become more prevalent in older individuals, possibly due to chromosomal instability?", "Does the image suggest disease progression or a transition from early to advanced cancer stages based on chromosomal abnormalities?"], "properties": ["Does the image show evidence of a chromosomal region with an increased size ranging from several megabases to an entire arm?", "Can you identify a chromosomal segment that appears to have an extra copy, resulting in a total of three copies?", "Is there a visible gain involving the long arm of a chromosome, particularly the region labeled as 1q?", "Does the image display an increased copy number specifically in the bands between 1q21 and 1q44?", "Is there a region where the DNA content appears to be increased by approximately 1.5-fold compared to normal?", "Can you detect a chromosomal abnormality that is commonly found in up to 40% of certain cancers such as multiple myeloma?", "Does the image reveal a duplicated region on a chromosome that is between 10 million and 100 million base pairs in length?", "Is there a segment with a gene density of roughly 10 to 15 genes per megabase?", "Can you identify a region with a GC content of about 41 to 42 percent?", "Does the image show a chromosomal region with a copy number ranging from three to five?", "Is there evidence that 10% to nearly 50% of a chromosome is affected by a gain, either segmental or involving a whole arm?", "Can you distinguish between whole-arm and segmental duplications in the chromosomal structure?"], "relational": ["Does the image show evidence of a chromosomal aberration affecting the largest chromosome in the human genome?", "Can you identify a structural variation involving the 1q arm or pericentromeric regions of a chromosome?", "Is there a visible increase in copy number affecting regions such as 1q21, 1q32, or 1p36?", "Does the image contain cells, such as neuroblastoma or hematopoietic cells, displaying chromosomal gains?", "Can you see a chromosome with a distinctive banding pattern and a prominent long arm that appears altered?", "Is there an abnormality involving the nuclear genome or mitotic chromosome compartment visible in the image?", "Does the image show a chromosomal structure interacting with the mitotic spindle or kinetochore that appears to have gained material?", "Can you identify a region within the cell nucleus where genes like MCL1 or JUN might be affected by increased copy number?", "Is there a human chromosome in the image that appears structurally related to chromosomes 2, 3, or 4 but shows evidence of gain?", "Does the image show a copy number variation involving the human chromosome set, specifically affecting the largest chromosome?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a chromosomal aberration that could increase the dosage of genes located on a specific chromosome?", "Is there a visual indication of altered cellular functions or disease phenotypes that might result from increased gene dosage?", "Can you identify features consistent with enhanced cellular growth or proliferation, possibly due to upregulation of oncogenes or cell cycle regulators?", "Does the image display characteristics of tumorigenesis or malignant transformation that could be linked to genomic instability?", "Are there signs of widespread changes in gene expression, such as overexpression of genes from a particular chromosomal region?", "Is there evidence of disrupted cell cycle regulation, such as increased expression of cyclins or abnormal cell division?", "Can you see features that suggest impaired DNA repair mechanisms or increased mutation rates?", "Does the image show characteristics associated with drug resistance, such as upregulation of efflux pumps or survival pathways?", "Are there visual cues indicating dysregulated cellular differentiation, possibly due to altered transcription factors or signaling pathways?", "Can you identify features that suggest inhibition of apoptosis, such as increased cell survival or reduced pro-apoptotic signaling?", "Is there evidence of altered metabolic pathways, such as enhanced glycolysis or lipid metabolism, that could result from changes in gene expression?", "Does the image show signs of immune evasion by tumor cells, such as overexpression of immune modulatory factors or suppression of immune recognition?"]}, "no_questions": {"contexual_properties": ["Does the image show a nodular appearance in a structure, which might be associated with chronic inflammation or multinodular changes?", "Is there visual evidence of increased secretions, which might be linked to hyperstimulation or an endocrine disorder?", "Does the image show a structure that appears enlarged, which could suggest infection, inflammation, or abnormal growth?"], "properties": ["Is there a structure whose volume could range from less than 1 mL to over 20 mL?", "Is there an object present whose weight might vary from less than a gram to around 30 grams depending on its type?", "Can you identify a structure with a tubular, acinar, or lobular shape?"], "relational": ["Can you identify a structure associated with ducts such as those for saliva, bile, sweat, or pancreatic secretions?", "Does the image show a component that could be found in the skin, pancreas, stomach, intestines, or mammary tissue?", "Does the image show a structure with nearby arteries, veins, or capillaries supplying it?"], "contexual_behavior": ["Is there a structure that would increase its activity during puberty in response to rising levels of gonadotropins and sex steroids?", "Is there a structure that could show reduced function after radiation exposure due to cellular damage and loss of secretory capacity?", "Can you see a structure that would increase enzyme release after food intake as part of the digestive process?"], "functions": ["Is there a structure present that could regulate fluid and electrolyte balance by releasing hormones such as aldosterone or antidiuretic hormone?", "Can you see a structure that might assist in the body's stress response by releasing hormones like cortisol or adrenaline?", "Can you identify an object that might regulate hormone secretion through feedback mechanisms involving the nervous or endocrine systems?"]}}, "basal-like": {"yes_questions": {"contexual_properties": ["Does the image show a region with increased cellular density that could indicate malignancy or tumor progression?", "Is there an area where nuclear size appears altered, suggesting dysplasia or neoplastic changes?", "Can you identify a region with high cellular proliferation, as might be seen in aggressive cancer subtypes?", "Does the image display tissue with altered protein expression, possibly due to oncogenic signaling or changes in the tumor microenvironment?", "Are there increased mitotic figures present, indicating rapid cell division as seen in certain carcinomas?", "Is there evidence of changes in cytoplasmic composition, which could be a sign of cellular stress or metabolic reprogramming?", "Can you see regions with increased necrosis, particularly in areas that may be poorly vascularized or in advanced cancer stages?", "Does the tissue exhibit abnormal morphology that could be associated with malignant progression or genetic mutations?", "Is there an increase in stromal content, possibly due to desmoplastic reactions or tumor-stroma interactions?", "Can you identify areas where the tissue appears more infiltrative, suggesting invasive growth or epithelial-mesenchymal transition?", "Are there regions that might display higher levels of biomarkers such as cytokeratin 5/6 or EGFR, as seen in certain breast cancers?", "Does the image show tissue with changes in color or appearance under staining, such as those observed with H&E or immunohistochemical stains?", "Is there evidence of increased fibrosis, which could result from chronic injury or stromal remodeling?", "Can you see signs of altered cell-to-cell adhesion, potentially due to reduced E-cadherin expression or tumor progression?", "Are there areas with increased immune cell infiltration, possibly indicating tumor-associated inflammation or an immune response?"], "properties": ["Does the image show cells with a high nuclear-to-cytoplasmic ratio and prominent nucleoli?", "Can you identify a population of poorly differentiated cells with elevated mitotic activity?", "Are there cells that appear basophilic, staining deep blue or purple under histological staining?", "Is there evidence of a cell group with positive expression for cytokeratin 5/6 or cytokeratin 14?", "Can you see cells that are likely to be negative for estrogen and progesterone receptors?", "Does the image contain cells with low or absent HER2 expression?", "Are there cells that appear to have a high proliferation rate, such as a high Ki-67 index?", "Can you identify cells that are approximately 10 to 20 micrometers in diameter?", "Is there a cell population that may express surface markers such as CD44 positive, CD24 negative, and EGFR positive?", "Do you observe features suggestive of high genomic instability, such as abnormal mitotic figures or pleomorphic nuclei?", "Are there cells that could be associated with mutations in TP53, BRCA1, or PTEN based on their morphology?", "Can you see a group of cells that might exhibit global hypomethylation or focal hypermethylation patterns?", "Is there evidence of high expression of proteins such as EGFR or P-cadherin in any cell population?"], "relational": ["Does the image show a tissue or organ that could be part of the breast, prostate, or skin?", "Can you identify cells that are located at the base of an epithelial tissue layer?", "Is there a structure present that is part of the integumentary or mammary glandular system?", "Does the image contain ducts or glands that might belong to the mammary gland or prostate?", "Can you see cells that are adjacent to or in close contact with the basement membrane?", "Is there evidence of cells with a high nuclear-to-cytoplasmic ratio?", "Does the image show epithelial tissue with distinct basal and luminal cell populations?", "Are there cells that could be classified as myoepithelial or basal epithelial cells?", "Can you identify regions containing both stromal and immune cells alongside epithelial cells?", "Is there a visible layer of cells providing structural support at the base of an epithelial tissue?", "Does the image include anatomical features of the epidermis or glandular ducts?", "Can you see evidence of expression patterns or features typical of basal cytokeratins?", "Is there a tissue subtype present that fits within the hierarchy of epithelial cell types?"], "contexual_behavior": ["Does the image show a tumor with increased proliferative activity, possibly in response to growth factor stimulation?", "Is there evidence of a neoplastic region that appears resistant to chemotherapy or shows features suggestive of recurrence after cytotoxic treatment?", "Can you identify a tumor area with impaired differentiation, potentially indicating disrupted lineage signaling during progression?", "Does the image reveal regions of increased invasiveness, especially in areas that might be hypoxic or show activation of hypoxia-inducible pathways?", "Is there a tumor component displaying altered immune evasion, such as evading immune surveillance or resisting immune checkpoint blockade?", "Can you see a neoplastic area with reduced hormone receptor signaling, such as lacking estrogen or progesterone receptor expression?", "Does the image suggest the presence of cells with stem cell-like characteristics, possibly enriched after radiation exposure?", "Is there evidence of heightened metabolic activity in tumor regions, potentially as an adaptation to glucose deprivation?", "Can you identify tumor areas with decreased apoptosis, possibly in response to targeted therapy or activation of anti-apoptotic pathways?", "Does the image show increased angiogenesis, particularly in hypoxic regions or during tumor progression?", "Is there a tumor region with signs of impaired DNA repair, such as features consistent with homologous recombination deficiency under genotoxic stress?", "Can you observe evidence of altered signaling pathways in tumor regions that might be adapting to new microenvironments during metastasis?", "Does the image suggest increased expression of drug efflux pumps in tumor cells, which could indicate multidrug resistance after chemotherapy?", "Is there a neoplastic area that appears unresponsive to endocrine therapy, possibly due to lack of hormone receptor expression or intrinsic resistance?", "Can you identify regions within the tumor microenvironment showing enhanced inflammatory signaling, especially in association with immune cell infiltration?"], "functions": ["Does the image show cells with high proliferative capacity or multipotency?", "Can you identify a cell population expressing markers typically found in basal cells?", "Is there evidence of progenitor cells contributing to tissue regeneration or differentiation into specialized cell types?", "Does the image display features consistent with maintenance of the epithelial barrier, such as replenishment of lost or damaged cells?", "Can you see cells participating in wound healing by proliferating or migrating toward an injury site?", "Is there evidence of cytokine production or interactions with immune cells that suggest modulation of local immune responses?", "Does the image show cells providing differentiation signals or influencing cell fate determination within the tissue?", "Can you identify a response to injury or stress characterized by activation of repair pathways and increased cell proliferation?", "Is there visual evidence of balanced self-renewal and differentiation supporting tissue homeostasis?", "Does the image suggest activation of signaling pathways such as Notch, Wnt/\u03b2-catenin, or EGFR during tissue repair?", "Can you observe interactions between epithelial cells and stromal or immune cells through paracrine signaling or direct contact to maintain tissue function?"]}, "no_questions": {"contexual_properties": ["Do any of these lines appear red, possibly due to irritation, dermatitis, or increased blood flow?", "Are there regions where these features look thickened, potentially from chronic friction, callus formation, or skin disorders?", "Is there any distortion of these lines, which might indicate burns, contractures, or severe skin disease?"], "properties": ["Are the main lines on the palm following a curved or arched path along the natural contours of the hand?", "Are there grooves on the palm that appear to be between 4 and 8 centimeters in length, depending on hand size?", "Are the grooves on the palm shallow, with a depth of about 0.5 to 1 millimeter?"], "relational": ["Are there markings on the palm that demarcate the flexion lines at the base or along the length of the fingers?", "Can you identify lines or creases that are associated with the metacarpophalangeal or interphalangeal joints?", "Are there visible features on the palm that correspond to the location of underlying muscles like the flexor digitorum superficialis or lumbricals?"], "contexual_behavior": ["Do the palm skin lines appear more visible, as might be seen after prolonged immersion in water?", "Is there evidence of skin folds on the palm that appear less defined, possibly due to increased hydration or swelling?", "Can you observe changes in the appearance of palm skin lines that could be due to acute inflammation, such as swelling or redness obscuring the usual patterns?"], "functions": ["Can you identify structures that allow the skin to fold smoothly during hand movement?", "Is there evidence of adaptations that improve grip by enabling the skin to conform to objects?", "Does the image show features that enhance the flexibility and range of motion of the palm?"]}}, "losses of chromosome 16": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of a chromosomal region with only one copy present, such as monosomy or partial monosomy?", "Can you identify a chromosomal abnormality involving deletions in regions like 16p13, 16q11, or 16q22-q24?", "Is there a visible loss affecting the chromosomal band 16q22 or its subregion 16q22.1?", "Does the image suggest a deletion spanning approximately 1 to 40 megabases, with an average size of 10 to 20 megabases?", "Can you detect decreased expression or haploinsufficiency of genes such as CBFB, CDH1, or CYLD in the sample?", "Is there evidence of a chromosomal alteration that occurs in about 10\u201320% of breast cancer or myeloid malignancy cases?", "Does the sample appear to have 20% to over 80% of cells exhibiting a specific chromosomal loss?", "Can you observe a minimal deleted region mapped to 16q22.1 within the chromosomal structure?"], "relational": ["Does the image show any tissues where genetic alterations might affect epithelial or renal tubular cells?", "Is there evidence of abnormalities in breast, kidney, or bone marrow tissue that could be linked to chromosomal changes?", "Can you identify structures belonging to the urinary or hematopoietic systems that might be impacted by chromosomal loss?", "Are there visual indications of cellular components, such as the spindle apparatus, that could be involved in detecting chromosomal abnormalities?", "Does the image include anatomical sites like the kidney or breast that are commonly associated with chromosomal losses in disease?", "Is there any sign of larger chromosomal abnormalities, such as monosomy or unbalanced translocations, affecting the depicted tissues?", "Can you observe any features suggesting involvement of the renal, hematologic, or endocrine systems due to chromosomal changes?", "Are there visual cues indicating the presence of hematopoietic cells or bone marrow tissue that could be affected by chromosomal loss?", "Does the image show any interaction between chromosomes or genetic structures, such as centromeres or homologous chromosomes, that might relate to chromosomal loss?", "Is there evidence of cell cycle checkpoints or DNA repair complexes in the depicted cells that could be responding to chromosomal abnormalities?"], "contexual_behavior": [], "functions": ["Is there evidence of genomic instability or gene dosage imbalance in any of the cells shown?", "Can you identify features suggestive of increased susceptibility to malignancies in the sample?", "Does the image show signs of disrupted cell growth or abnormal signaling pathways?", "Are there indications of impaired DNA repair mechanisms, such as defects in homologous recombination?", "Can you observe decreased expression or absence of genes typically located on a specific chromosome, leading to cellular dysregulation?", "Is there visual evidence of cell cycle dysregulation, such as abnormal mitotic figures or loss of cell cycle checkpoints?", "Do any of the cells display characteristics associated with tumor suppressor loss?", "Are there features consistent with oncogenic transformation or malignant progression?", "Can you detect signs of metabolic disruption, such as altered lipid metabolism or energy homeostasis, in the tissue?", "Is there evidence of compromised immune cell development or impaired immune response in the image?", "Do you observe abnormalities in biological pathways related to cell cycle regulation, DNA repair, or metabolism?", "Are there indications of enhanced tumor aggressiveness, therapy resistance, or metastatic potential?", "Can you identify abnormal cellular differentiation or lineage commitment, suggesting developmental abnormalities?", "Is there evidence of altered apoptosis regulation or changes in cell survival, such as increased or decreased programmed cell death?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure that might contain fluid with a faint or mild odor?", "Can you see a cystic lesion where the fluid is likely to have a high water content, over 90 percent?", "Does the image show a cystic structure containing fluid that appears straw-colored or yellow?"], "relational": ["Does the image show a structure associated with the integumentary system?", "Can you identify an area containing both epithelial and connective tissue?", "Is there a visible abnormality involving the dermis or epidermis?"], "contexual_behavior": ["Is there a lesion that could fail to clear cellular debris in the context of chronic disease and persistent inflammation?", "Can you identify a cyst that might show reduced antimicrobial activity in an immunosuppressed patient?", "Is there evidence of increased fluid accumulation in a cystic area that could be explained by recent trauma or tissue injury?"], "functions": ["Is there visual evidence of a mild local immune response, such as chronic inflammation or recruitment of immune cells?", "Does the image display any alteration in local moisture balance or features that might predispose to secondary infection?", "Can you identify a structure that acts as a reservoir for secreted fluid, suggesting retention rather than normal excretion onto the skin surface?"]}}, "her2": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a membranous brown staining pattern when using DAB chromogen in immunohistochemistry?", "Is there evidence of a protein with an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular tyrosine kinase domain?", "Can you identify a structure that is glycosylated at multiple asparagine residues in its extracellular region?", "Does the image suggest low expression of a certain protein in healthy epithelial tissues?", "Is there an indication of a protein whose normal concentration in serum is less than 15 ng/mL?", "Can you observe features consistent with a protein encoded by a gene located on chromosome 17 at position 17q12?", "Is there evidence of a protein that typically has a length of 1,255 amino acids?", "Does the image suggest the presence of a protein with a molecular weight around 185 kilodaltons?", "Can you see signs of low mRNA expression for a particular protein in non-cancerous tissue?", "Is there an indication of a protein that is normally present in two gene copies per cell?", "Does the image suggest a low or unphosphorylated state for a membrane-associated protein in healthy cells?"], "relational": ["Does the image show cells with prominent features at the plasma membrane or cell surface?", "Can you identify epithelial or tumor cells that might display specific membrane-associated markers?", "Is there evidence of marker expression in breast tissue or gastric mucosa within the image?", "Does the image contain structures belonging to the mammary gland or gastrointestinal system that could exhibit specialized cell surface proteins?", "Can you see any indications of molecular complexes involving membrane proteins, such as heterodimers?", "Is there visual evidence of interactions between membrane components, such as lipid rafts or receptor tyrosine kinases?", "Does the image suggest the presence of receptor assemblies that could include proteins like HER3 or HER4?", "Are there regions in the breast or upper gastrointestinal tract that appear to have high levels of a particular cell surface marker?", "Can you identify features that might be associated with the EGFR family of receptors based on their localization or clustering?", "Is there any indication of shared structural domains or signaling pathways among membrane-bound receptors in the image?", "Do you observe any cellular compartments, such as intracellular vesicles, that might contain membrane-associated proteins?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a receptor tyrosine kinase involved in regulating cell growth or differentiation?", "Is there a structure present that could activate intracellular signaling cascades such as the MAPK or PI3K/AKT pathways to promote cell proliferation?", "Can you identify features suggesting receptor dimerization or signal transduction from the cell surface to the nucleus?", "Does the image contain evidence of enhanced cell cycle progression or signal amplification driving proliferation?", "Is there a region in the image where epithelial cell growth or maintenance of tissue architecture is apparent?", "Can you observe signs of signaling modulation influencing cell fate or differentiation?", "Is there visual evidence of uncontrolled cell division or tumorigenesis that could be linked to overexpression of a growth-promoting receptor?", "Does the image suggest increased sensitivity to growth factors or amplification of growth-promoting signals in certain cells?", "Can you identify areas where anti-apoptotic signaling or inhibition of programmed cell death might be occurring?", "Is there evidence of interaction between receptor proteins such as EGFR, HER3, or HER4 through heterodimerization?", "Does the image show features consistent with accelerated tumor progression, such as increased proliferation, invasion, or resistance to apoptosis?", "Can you see indications of tissue repair or regeneration involving stimulated cell proliferation and migration in response to injury?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system and projects into the vaginal canal?", "Is there a visible area that forms part of the cervical portio vaginalis?", "Does the image contain a portion of tissue that is contiguous with the endocervix at the squamocolumnar junction?"], "contexual_behavior": ["Is there evidence of increased vascular permeability, such as edema or leukocyte infiltration, associated with acute inflammation?", "Can you see any indication that protective function during menstruation might be reduced due to weakened epithelial barriers or immune defenses?", "Is there a region that appears to have reduced barrier function against pathogens, possibly indicating increased susceptibility to infection?"], "functions": ["Can you see features suggesting the release of inflammatory mediators, such as localized redness or edema?", "Can you identify a region where immune cells like neutrophils or macrophages might be recruited to the site of inflammation?", "Can you identify a region where antimicrobial activity might be enhanced, such as increased secretion or surface changes?"]}}, "type of cancer": {"yes_questions": {"contexual_properties": ["Does the image show a mass that appears to be increasing in size, suggesting rapid cell proliferation?", "Is there evidence of a lesion that has decreased in size, possibly indicating a response to therapy or cell death?", "Can you identify an area with altered color that might reflect changes in vascularity, hemorrhage, or necrosis?", "Does the image reveal a structure with increased blood vessel formation, consistent with neovascularization?", "Is there a region within a mass that appears necrotic, possibly due to insufficient blood supply?", "Can you see a lesion that looks denser than surrounding tissue, which could be due to increased cellularity or fibrosis?", "Is there an area within a mass that appears less dense, suggesting necrosis or cystic change?", "Does the image show cells with abnormal shapes or sizes, indicating increased cellular atypia?", "Can you identify any calcified regions within a mass, which may result from mineralization of necrotic tissue?", "Is there a surface defect or ulceration visible, possibly due to invasion and destruction of overlying tissue?", "Does the image show changes in tissue composition, such as areas of metaplasia or stromal reaction?", "Is there evidence of a structure infiltrating into adjacent tissues, suggesting invasiveness and basement membrane breach?", "Can you see cystic regions or fluid-filled spaces within a mass, indicating degeneration or fluid accumulation?", "Are there increased mitotic figures visible, suggesting heightened cell division?", "Does the image show a mass surrounded by a fibrous capsule, which could indicate encapsulation?", "Is there loss of normal tissue architecture or organization, possibly due to malignant invasion?", "Can you identify areas with increased metabolic activity, such as regions that might appear more active on specialized imaging?", "Is there evidence of hemorrhage within a lesion, such as areas of internal bleeding?", "Does the mass appear to have increased in weight or bulk, consistent with tumor expansion?", "Are there abnormal surface features, such as irregular contour or texture changes, present on the lesion?"], "properties": ["Does the image show a mass with a diameter between 1 and 5 centimeters?", "Is there a structure with an irregular or nodular outline rather than a smooth border?", "Can you identify a lesion that appears to have grown rapidly or slowly, suggesting variable growth rates?", "Does the tissue in the image appear pale, grayish-white, or show areas of hemorrhage?", "Is there evidence of a mass composed of a mix of different cell types, such as malignant, stromal, immune, or endothelial cells?", "Can you see regions where cell division appears increased compared to surrounding tissue?", "Is there a population of cells with enlarged nuclei and reduced cytoplasm, indicating a high nuclear-to-cytoplasmic ratio?", "Does the image suggest abnormal DNA content in cells, such as aneuploidy or polyploidy?", "Can you identify a lesion that could be classified as low, intermediate, or high grade based on cellular features and mitotic activity?", "Are there areas of necrosis present within the mass, especially in regions that appear more aggressive?", "Does the structure show increased vascularity, possibly due to new blood vessel formation?", "Is there evidence of elevated expression of tumor markers, such as CEA, CA-125, or PSA, in the tissue?", "Can you infer a high mutation burden in the cells present, compared to normal tissue?", "Are there regions with a high proliferation index, as might be indicated by markers like Ki-67?", "Does the tissue show varying levels of differentiation, from well-differentiated to poorly differentiated areas?", "Can you detect chromosomal abnormalities such as translocations, deletions, duplications, or aneuploidy in the cells?", "Is the density of the mass higher than that of the surrounding normal tissue, suggesting increased cellularity?", "Does the lesion exhibit increased metabolic activity, such as high glucose uptake?", "Is there evidence of hormone receptor positivity, such as ER or PR expression, in the tissue?", "Can you identify overexpression of specific antigens like HER2, EGFR, or CD20 in the mass?"], "relational": ["Does the image show evidence of a process affecting the respiratory, digestive, reproductive, or nervous systems?", "Can you identify an abnormality originating from epithelial, connective, muscle, or hematopoietic tissues?", "Is there a visible lesion or mass in regions such as the lungs, liver, breast, colon, or skin?", "Does the image display changes involving epithelial cells, lymphocytes, melanocytes, or glial cells?", "Can you see any indication of invasion into blood vessels, lymphatic vessels, nerves, or adjacent organs?", "Is there involvement of regional lymph nodes, lymphatic capillaries, or the thoracic duct visible in the image?", "Does the image suggest spread to distant sites such as the liver, lungs, bones, or brain?", "Are there disruptions or breaches of anatomical boundaries like the organ capsule, serosal surface, basement membrane, or tissue planes?", "Can you observe interactions with the immune, circulatory, or endocrine systems in the context of abnormal tissue growth?", "Is there visual evidence of connective tissue changes such as desmoplasia, fibrosis, or tissue remodeling surrounding a lesion?"], "contexual_behavior": ["Does the image show evidence of increased cell proliferation that could be associated with adaptation to low oxygen conditions?", "Can you identify features suggesting resistance to apoptosis, possibly as a result of chemotherapy exposure?", "Is there visual evidence of enhanced blood vessel formation that might indicate a response to nutrient deprivation?", "Does the image suggest increased antigen presentation or immune cell infiltration that could follow immunotherapy?", "Are there signs of increased metastatic spread that might be linked to chronic inflammation in the surrounding tissue?", "Can you observe a reduction in cell proliferation that could be due to inhibition of oncogenic signaling pathways by targeted therapy?", "Is there evidence of altered metabolic activity, such as increased reliance on alternative energy sources, in regions that might be low in glucose?", "Does the image reveal areas of unrepaired DNA damage that could be consistent with defects in DNA repair mechanisms after radiation exposure?", "Are there features indicating increased invasiveness, such as changes in cell morphology, that may be driven by growth factor signaling?", "Can you detect a decrease in hormone receptor expression or altered growth patterns that might result from endocrine therapy?", "Is there evidence of reduced immune cell infiltration or decreased antigen visibility that could be associated with immunosuppression?", "Does the image suggest increased drug efflux activity, such as overexpression of membrane transporters, following prolonged drug exposure?", "Are there signs of reduced angiogenic signaling, such as fewer new blood vessels, that might result from anti-angiogenic treatment?", "Can you observe changes in cell signaling or tissue architecture that could reflect adaptation to microenvironmental changes?", "Is there evidence of increased glycolytic activity, such as high cellular density or metabolic byproducts, during rapid growth phases?", "Does the image suggest loss of tumor suppressor gene function, possibly in the context of a genetic syndrome?", "Are there features indicating enrichment of stem cell-like populations, such as after a relapse event?", "Can you detect reduced antigen presentation, such as decreased MHC molecule expression, in the context of chronic infection?", "Is there evidence of enhanced antioxidant defenses or stress response mechanisms that might be activated during oxidative stress?", "Does the image show areas of reduced growth or cellular dormancy that could be associated with nutrient restriction?"], "functions": ["Does the image show evidence of abnormal cell growth that could indicate uncontrolled proliferation?", "Can you identify regions where normal tissue architecture appears disrupted or replaced by atypical cells?", "Is there visual evidence of tissue invasion or structures suggesting spread into surrounding areas?", "Does the image reveal features consistent with impaired organ function or tissue destruction?", "Can you observe increased blood vessel formation that might suggest stimulation of angiogenesis?", "Is there a visible area where cells appear densely packed, possibly indicating evasion of growth suppressors?", "Does the image show signs of altered cellular organization that could be due to genomic instability or cell cycle dysregulation?", "Can you identify regions where normal immune cell infiltration seems reduced, suggesting evasion of immune surveillance?", "Is there evidence of abnormal metabolic activity, such as increased cellular density or altered tissue appearance, that could indicate a glycolytic shift?", "Does the image contain features suggesting continuous cell division or loss of normal cell cycle checkpoints?", "Can you see signs of stromal cell recruitment or increased inflammation in the surrounding tissue?", "Is there evidence of abnormal signaling, such as regions with excessive growth or lack of regulatory feedback?", "Does the image show areas with increased nutrient or oxygen supply, possibly due to upregulated transporters or angiogenesis?", "Can you identify features that might indicate resistance to cell death, such as persistent abnormal cell clusters?", "Is there visual evidence of distant colonization or spread to other organs, suggesting metastatic potential?", "Does the image show signs of systemic effects, such as tissue wasting or changes that could be linked to cachexia?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure where melanin pigment is present in both a colored ring and a pigmented epithelial layer?", "Is there a structure with a spherical or slightly ovoid shape present?", "Does the image include an object with a firm exterior and a gelatinous interior?"], "relational": ["Can you see a structure directly connected to a neural pathway that transmits visual information to the brain?", "Are the fibrous, vascular, or neural layers visible in any of the dissected regions?", "Does the image show a structure that is part of the visual or sensory system?"], "contexual_behavior": ["Can you see a sample that would fail to maintain ionic gradients after membrane disruption caused by injury?", "Is there a structure that would show reduced responsiveness to light stimuli at low temperatures due to slowed enzymatic activity?", "Is there a structure that would display decreased visual pigment regeneration in darkness if metabolic pathways were disrupted?"], "functions": ["Can you see a preparation that could be exposed to light stimuli for measuring electrophysiological or molecular responses?", "Is there a specimen that would allow direct application of drugs to observe pharmacological effects on ocular tissues?", "Does the image show a preparation that could facilitate research on cellular differentiation or regenerative processes in the eye?"]}}, "precursor lesion": {"yes_questions": {"contexual_properties": ["Does the image show an area that appears to be increasing in size compared to surrounding tissue?", "Is there a region with more irregular borders than adjacent structures?", "Can you identify a lesion that displays a change in color, possibly due to altered vascularity or hemorrhage?", "Is there a visible area that appears thicker than the surrounding tissue?", "Does the image reveal a region with abnormal cellular composition or signs of cellular atypia?", "Can you see evidence of increased cellular density or hypercellularity in any lesion?", "Is there a structure that appears to have developed new or increased blood vessels, suggesting angiogenesis?", "Does the image show any areas with calcifications or signs of dystrophic mineralization?", "Is there a region where the normal tissue architecture appears distorted or disorganized?", "Can you identify a lesion with surface breakdown or ulceration?", "Does the image reveal areas with increased mitotic figures or signs of active cellular proliferation?", "Is there a region where normal tissue polarity or structure seems to be lost?", "Can you see any areas of necrosis or tissue death within a lesion?", "Is there evidence of abnormal protein accumulation, such as amyloid deposits, within a lesion?", "Does the image show a mass that appears palpable or firmer than the surrounding tissue?", "Is there a region that might exhibit increased metabolic uptake or hypermetabolism?", "Can you identify a lesion with a change in texture, possibly due to fibrosis or edema?", "Is there an area that appears more firm, suggesting increased fibrous tissue or cellular density?", "Does the image reveal any changes in molecular markers or features suggestive of genetic or epigenetic alterations?"], "properties": ["Is there a small structure, less than 1 cm in diameter, visible in the image?", "Can you identify an area with an irregular or oval shape compared to the surrounding tissue?", "Does the image show a region that appears pale, erythematous, or otherwise discolored relative to adjacent tissue?", "Is there a zone where the cellular density appears increased compared to normal areas?", "Can you see a region that might contain dysplastic epithelial cells or possibly some inflammatory cells?", "Does the image show an area where the mitotic activity is elevated but not as high as in malignant lesions?", "Is there evidence of cells with a higher nuclear-to-cytoplasmic ratio than normal?", "Can you identify a region where cellular atypia appears mild to moderate?", "Is there a thin area, often less than 1 mm thick, limited to the epithelial layer?", "Does the image reveal a disorganized architectural pattern or loss of normal tissue polarity?", "Is there a region that could correspond to low- or moderate-grade dysplasia?", "Can you see an area where the proliferation rate of cells seems increased compared to normal tissue?", "Is there evidence of increased expression of molecular markers such as Ki-67 or abnormal p53 in any region?", "Does the image show an area with variable or minimal keratinization, especially in non-keratinizing epithelia?", "Can you identify a region where the number of cell layers exceeds typical epithelial stratification?", "Is there evidence of cells with hyperchromatic and irregular chromatin patterns?", "Does any area suggest mild to moderate aneuploidy in DNA content?", "Is there a region where necrosis is absent or minimal?", "Can you see an area with mild or variable inflammation?", "Does the image show a region with slightly increased vascularity compared to normal tissue?"], "relational": ["Does the image show an area within epithelial, glandular, or mucosal tissue that appears abnormal?", "Can you identify a region in the digestive, respiratory, or reproductive system that displays early pathological changes?", "Is there evidence of dysplastic or atypical epithelial cells in any tissue shown?", "Does the image contain a localized area of abnormal cells adjacent to normal tissue, basement membrane, or stromal tissue?", "Can you see a structure that could potentially give rise to malignant tumors or carcinomas if left untreated?", "Is there a region exhibiting cellular atypia or localized growth that remains non-invasive?", "Does the image include changes within the colon, cervix, lung, or breast that suggest an early pathological process?", "Can you identify abnormal features on mucosal surfaces, transitional zones, or epithelial linings?", "Is there evidence of cellular dysplasia, architectural distortion, or loss of polarity in any tissue region?", "Does the image show a lesion that appears to be at an intermediate stage between normal tissue and overt malignancy?"], "contexual_behavior": ["Does the image show a structure with increased cellular proliferation, possibly in response to growth factors or oncogenic signals?", "Is there evidence of a region where DNA repair mechanisms might be compromised due to genetic or epigenetic alterations?", "Can you identify an area that appears more resistant to apoptosis, potentially due to upregulated anti-apoptotic signaling?", "Does the image display a region with increased angiogenic activity, such as enhanced blood vessel formation, possibly under hypoxic conditions or influenced by VEGF?", "Is there a structure that appears less differentiated, which could be due to mutations affecting differentiation-related genes or pathways?", "Can you see evidence of accelerated progression toward malignancy, such as features suggesting the accumulation of driver mutations or changes in the surrounding microenvironment?", "Is there a region where immune surveillance seems reduced, possibly due to the activation of immune evasion mechanisms or upregulation of checkpoint molecules?", "Does the image show metabolic changes, such as increased glycolysis or lactate production, that might occur under hypoxic conditions?", "Can you identify an area where normal tissue architecture is disrupted, perhaps due to loss of cell polarity or downregulation of adhesion molecules?", "Is there evidence of increased invasive potential, such as tissue infiltration, that could be associated with chronic inflammation and the release of proteolytic enzymes?", "Does the image suggest slowed progression of abnormal tissue, possibly as a result of chemopreventive agents that inhibit proliferation or induce apoptosis?", "Is there a region with signs of impaired cell cycle regulation, such as abnormal mitotic figures, which could result from inactivation of tumor suppressor genes or checkpoints?", "Can you see features that might indicate enhanced immune evasion, such as reduced antigen presentation or expression of immune-inhibitory molecules?", "Is there evidence of decreased apoptotic signaling in response to environmental toxins, possibly due to activation of survival pathways?", "Does the image show increased genomic instability, such as nuclear atypia, which might be associated with oxidative stress and impaired DNA repair?", "Can you identify a region with an altered secretory profile, such as increased release of cytokines or extracellular vesicles, possibly in response to growth factors?", "Is there evidence of compromised barrier function, such as loss of tight junctions or disrupted epithelial integrity?", "Does the image suggest increased susceptibility to malignant transformation, potentially during hormonal changes that promote proliferation or inhibit apoptosis?", "Is there a region where abnormal cell growth is not limited after injury, possibly due to disrupted regulatory feedback mechanisms?", "Can you see evidence of behavioral changes in response to targeted therapy, such as features suggesting resistance mechanisms or altered signaling pathways?"], "functions": ["Does the image show an area where tissue appears abnormal in a way that could indicate early disease development?", "Is there evidence of changes that might signal the initiation of a pathological process, such as early oncogenesis?", "Can you identify a region with features like dysplasia or atypical cell proliferation?", "Does the image reveal architectural distortion or altered tissue structure suggestive of early abnormality?", "Is there a visible area where the extracellular matrix appears remodeled or where local inflammation is present?", "Can you see signs of uncontrolled cell growth, such as increased cell density or loss of normal regulatory patterns?", "Is there evidence of disrupted cell signaling, such as irregular growth or differentiation patterns?", "Does the image show regions where gene expression or cell cycle control might be altered, as indicated by abnormal cell morphology?", "Can you identify areas with immune cell infiltration or features that suggest evasion of immune surveillance?", "Is there a region where normal tissue function or organ architecture appears disrupted?", "Does the image show evidence of impaired cell differentiation, such as loss of specialized cell features or abnormal lineage patterns?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show a cord-like structure with a thickness of about 1.5 to 2 centimeters near the neck?", "Is there any indication that blood flow through the cord-like structure is maintained, or are there signs of possible compromise due to tightness?", "Can you see a cord-like structure that may contain a gelatinous substance rich in mucopolysaccharides such as hyaluronic acid and chondroitin sulfate?"], "relational": ["Does the cord connect to the abdominal wall or umbilicus while looping around the neck?", "Can you identify a cord that appears to be affecting the respiratory or circulatory systems by its position around the neck?", "Is there evidence of a structure encircling the cervical region of a newborn?"], "contexual_behavior": ["Does the image depict a scenario that may be associated with perinatal complications involving the neck of a newborn?", "Does the image show a situation where a flexible structure is wrapped around the neck of a newborn?", "Is there a visible indication of a structure that could potentially compromise the airway or circulation in a newborn's neck area?"], "functions": ["Can you identify any visual evidence of bradycardia or abnormal heart rate in the newborn?", "Does the image suggest the presence of birth-related stress responses, such as irritability or increased sympathetic activity?", "Is there any indication of hypotonia or neurological impairment in the newborn?"]}}, "er": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the endomembrane system?", "Can you identify a feature present in eukaryotic cells such as hepatocytes or neurons?", "Is there a structure that appears continuous with the nuclear envelope?", "Does the image show an organelle interacting with the Golgi apparatus or mitochondria?", "Can you see regions that could correspond to both rough and smooth forms of a membranous network?", "Is there evidence of a continuous membrane system connecting the nuclear envelope to another organelle?", "Does the image display a compartment that is connected to the cytosol and the Golgi apparatus?", "Are there visible ribosomes or complexes such as translocons associated with a membrane structure?", "Can you identify vesicular transport occurring between a membranous network and the Golgi apparatus?", "Is there a structure anchored by cytoskeletal elements like microtubules or actin filaments?"], "contexual_behavior": ["Does the image show a structure that increases protein synthesis in response to growth factor stimulation or high cellular demand?", "Is there evidence of a component that reduces its protein folding capacity during prolonged cellular stress or when chaperone proteins are depleted?", "Can you identify a structure that might exhibit impaired calcium storage under conditions such as hypoxia or oxidative damage?", "Does the image contain a feature that enhances lipid synthesis during periods of increased metabolic demand, such as cell growth or adipogenesis?", "Is there a region where misfolded proteins might accumulate due to overwhelmed degradation pathways or proteasome dysfunction?", "Can you see a structure that would activate the unfolded protein response when misfolded proteins build up under stress?", "Is there evidence of decreased detoxification activity in association with liver disease, such as cirrhosis or hepatitis?", "Does the image suggest altered function of a structure that could be hijacked by viruses for replication and protein synthesis during infection?", "Can you identify an area where chaperone activity might increase in response to heat shock to protect proteins from denaturation?", "Is there a feature that shows reduced calcium release during muscle fatigue, possibly due to impaired calcium channels or energy depletion?", "Does the image contain a structure that could become dysfunctional in neurodegenerative diseases like Alzheimer's or Parkinson's disease?", "Is there evidence of increased autophagy activity during nutrient deprivation to support cellular survival?", "Can you see a component that fails to maintain membrane lipid balance in the context of metabolic syndrome due to disrupted lipid metabolism?", "Does the image show a structure that enhances protein export during immune activation to support secretion of immune mediators?", "Is there a region where function is reduced due to oxidative stress, leading to protein damage and impaired processes?"], "functions": ["Is there a structure in the image that serves as a site for protein synthesis and folding?", "Can you identify an organelle involved in lipid metabolism or membrane biogenesis?", "Does the image show a cellular component responsible for calcium storage and release?", "Is there evidence of a structure that assists in detoxification, possibly through cytochrome P450 activity?", "Can you see a region where ribosomes might be attached for mRNA translation?", "Is there a visible feature associated with the transport of proteins to the Golgi apparatus?", "Does the image contain an area where molecular chaperones could facilitate protein folding?", "Can you identify a structure that monitors protein quality and targets misfolded proteins for degradation?", "Is there an organelle present that participates in calcium signaling or interacts with signaling proteins?", "Does the image show a component that interacts closely with the Golgi apparatus, mitochondria, or lysosomes?"]}, "no_questions": {"contexual_properties": ["Does any area show increased vascularity, possibly due to chronic inflammation or healing?", "Is there a surface that appears inflamed, suggesting infection, autoimmune disease, or irritation?", "Can you see any ulcers or breaks in a lining that might be associated with Crohn's disease or infection?"], "properties": ["Can you see an area with high vascular density to support nutrient exchange and immune function?", "Can you identify a region that displays a pink or reddish coloration due to high vascularity?", "Does the image show a layer composed of epithelial cells, connective tissue, blood vessels, and mucus?"], "relational": ["Does the image include regions like the oral cavity, nasal cavity, gastrointestinal tract, or genitourinary tract with a specialized internal surface?", "Can you identify a boundary between an innermost lining and adjacent layers such as the submucosa or muscularis externa in a hollow organ?", "Does the image display a layered wall where the innermost lining is directly superficial to a deeper submucosal region?"], "contexual_behavior": ["Does the image show a tissue layer that may lose its protective function due to immune-mediated epithelial damage, as seen in autoimmune disorders?", "Is there a tissue that could show impaired function as a result of medication side effects, such as injury from NSAIDs or chemotherapy?", "Is there a structure that might fail to prevent pathogen entry if immune surveillance and barrier functions are compromised, as in immunodeficiency?"], "functions": ["Does the image show a tissue layer that provides protection, absorption, secretion, or sensation within an organ system?", "Does the image reveal sensory receptors or nerve endings embedded within a tissue layer?", "Can you identify features suggesting tissue repair or regeneration, such as areas of cellular proliferation or resident stem cells?"]}}, "skin stem cells": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a tissue that is part of the integumentary system?", "Can you identify a region corresponding to the basal layer of the epidermis?", "Is there a structure resembling the bulge region of a hair follicle?", "Does the image include both epidermal and dermal tissue?", "Can you see cells that are likely to interact with the basement membrane?", "Is there evidence of structures such as hair follicles or sebaceous glands?", "Does the image show features associated with the regeneration or maintenance of hair follicles?", "Can you identify areas that might be involved in the renewal or repair of the epidermis?", "Is there a visible presence of related cell types such as keratinocytes or melanocytes?", "Does the image suggest the presence of transit-amplifying cells within the skin layers?", "Can you see extracellular matrix components like collagen, laminin, or fibronectin surrounding skin structures?", "Is there evidence of anatomical regions such as the scalp, limbs, or trunk depicted in the image?", "Does the image include structures that could be associated with melanocyte stem cells or dermal papilla stem cells?"], "contexual_behavior": ["Does the image show evidence of increased tissue regeneration or repair shortly after an acute skin injury?", "Is there a visible indication of reduced tissue renewal or thinning that could be associated with aging or cellular senescence?", "Can you identify signs of impaired healing or persistent inflammation in a chronic wound?", "Is there evidence of enhanced cellular differentiation or protective adaptation in response to UV exposure?", "Does the image display features of inflammatory skin diseases, such as psoriasis or atopic dermatitis, that might suggest impaired regenerative function?", "Are there visual cues of decreased regenerative activity or diminished repair potential that could be linked to prolonged stress?", "Is there accelerated tissue repair, increased cell proliferation, or migration visible in the context of a burn injury?", "Can you see signs of loss of self-renewal or abnormal skin structure that might be associated with genetic disorders like epidermolysis bullosa?", "Is there evidence of increased cell migration or repopulation of damaged areas during wound healing?", "Does the image suggest reduced maintenance of the epidermis or compromised skin integrity that could be related to diabetes or metabolic dysfunction?", "Are there features indicating altered cellular behavior or immune modulation in response to infection?", "Can you identify signs of skin barrier dysfunction or lesions that might be linked to autoimmune conditions such as lupus erythematosus?", "Is there evidence of rapid tissue turnover or hyperproliferation, such as increased cell division after injury?", "Does the image show decreased regenerative capacity, thinning, or damage that could be attributed to radiation exposure?", "Are there abnormalities in skin structure or differentiation that might result from exposure to chemical irritants?"], "functions": ["Does the image show evidence of cells that are actively maintaining or repairing skin tissue?", "Can you identify areas where new keratinocytes or other skin cell types are being generated after injury or normal turnover?", "Is there visual indication of cell migration or proliferation at a wound site, suggesting restoration of the epidermal barrier?", "Does the image display features consistent with continuous replenishment of lost or damaged skin cells to maintain tissue balance?", "Can you see signs of specialized skin cells reconstructing the epidermis or dermis after tissue damage?", "Is there evidence of cell division and integration into existing skin layers to replace lost or dead cells?", "Does the image suggest a constant supply of new cells to the skin surface, indicating active epidermal turnover?", "Are there visual cues of cellular activation, proliferation, or migration in response to skin injury?", "Can you observe features that indicate regeneration of the skin barrier or removal of damaged cells after environmental exposure?", "Is there evidence of cells differentiating into follicular structures, supporting hair follicle formation or development?", "Does the image show interactions between skin cells and immune cells, or maintenance of physical and immunological barriers in the skin?"]}, "no_questions": {"contexual_properties": ["Does the image contain a pair of connected structures to the left of the uterus, one appearing as a tube and the other as a rounded organ?", "Can you identify a structure on the left of the uterus that may be involved in transporting gametes?", "Is there an organ located to the left of the uterus that could be part of the female reproductive system?"], "properties": ["Does the image contain a left-sided anatomical feature next to the uterus that may be part of the female reproductive system?", "Does the image show a tubular structure adjacent to the left side of the uterus?", "Can you identify an organ on the left of the uterus that is typically paired and involved in gamete production?"], "relational": ["Is there evidence of a tubular structure and an ovoid organ connected by ligaments on the left side of the uterus?", "Does the image display anatomical features such as the mesosalpinx or infundibulopelvic ligament adjacent to the uterus?", "Is there a region adjacent to the sigmoid colon or left ureter that contains reproductive structures?"], "contexual_behavior": ["Is there a structure visible to the left of the uterus that could be part of the female reproductive system?", "Is there a visible connection between a tube-like structure and an organ on the left of the uterus?", "Can you see a pair of structures to the left of the uterus that are typically associated with ovulation and gamete transport?"], "functions": ["Is there a visible area that might support early pregnancy by producing progesterone to maintain the uterine lining on the left?", "Is there a region that facilitates the transport of gametes from the ovary toward the uterus on the left side?", "Can you identify a structure that creates a favorable environment for sperm guidance and chemotaxis on the left side?"]}}, "invasive er-positive carcinomas": {"yes_questions": {"contexual_properties": ["Does the image show a mass that appears to have increased in size, suggesting unchecked cell proliferation or tumor progression?", "Is there evidence of a lesion that has decreased in size, possibly indicating a response to endocrine therapy or chemotherapy?", "Can you identify a tumor with regions of varying cellular composition, which might reflect clonal selection or therapy-induced changes?", "Is there a structure displaying high mitotic activity or features consistent with a high-grade lesion?", "Does the image reveal areas of necrosis within a tumor, possibly due to rapid growth outpacing blood supply or following cytotoxic treatment?", "Can you see fibrotic regions within a mass, suggesting desmoplasia or a stromal reaction to chronic inflammation or tumor regression?", "Is there a change in color within a lesion, such as areas of hemorrhage or necrosis, or changes following therapy?", "Are there visible calcifications within a tumor, which could be associated with necrosis or post-treatment changes?", "Does the image suggest increased estrogen receptor expression in a lesion, possibly due to hormonal stimulation or genetic alterations?", "Is there evidence of reduced estrogen receptor expression in a tumor, which might indicate progression, dedifferentiation, or therapy resistance?", "Can you identify a mass with heterogeneous structural features, possibly reflecting tumor evolution or therapy response?", "Is there increased vascularity within a lesion, suggesting angiogenesis associated with tumor growth or progression?", "Does the tumor exhibit cystic changes, which could result from necrosis, degeneration, or treatment effects?", "Is there evidence of increased cellular atypia within a mass, consistent with a higher grade or genetic instability?", "Can you observe changes in density within a lesion on imaging, possibly due to necrosis, fibrosis, or therapeutic response?", "Does the image suggest altered hormone receptor status in a tumor, which could be due to progression, clonal selection, or therapy resistance?", "Is there a mass with infiltrative borders, indicating progression to a higher grade or acquisition of invasive characteristics?", "Can you identify mucinous components within a tumor, suggesting differentiation into mucin-producing subtypes or histological heterogeneity?", "Does the lesion show a high proliferation index, indicating active tumor growth or a high-grade nature?", "Is there a change in texture or firmness of a mass, possibly due to fibrosis, necrosis, or a desmoplastic reaction?"], "properties": ["Is there a mass in the image measuring between 1 and 5 centimeters in size?", "Can you identify a lesion that might weigh between 1 and 30 grams based on its dimensions?", "Does the image show a structure with an irregular or nodular outline?", "Is there an area with a white to tan coloration on gross examination?", "Can you detect a region that could correspond to a histological grade of 1 or 2?", "Is there evidence of moderate to high cellular density compared to surrounding tissue?", "Does the image suggest a low to intermediate rate of cell division, as indicated by mitotic figures?", "Can you identify a region where estrogen receptor expression might exceed 1%, possibly over 70% of cells?", "Is there a structure where progesterone receptor positivity could range from 20% to over 80%?", "Does the image show a lesion that is likely negative or equivocal for HER2 expression?", "Is there an area where the Ki-67 proliferation index appears low to moderate, likely under 20%?", "Can you see nuclei that display mild to moderate variation in size and shape?", "Is there evidence of well to moderately differentiated tubule formation, suggesting a low to intermediate score?", "Does the lesion appear to lack significant necrosis, or show only minimal necrotic areas?", "Is there a moderate amount of fibrous stroma present within the lesion?", "Can you identify a region where the DNA content is likely diploid?", "Is there a tumor area where the proportion of tumor cells exceeds 60% of the total area?", "Does the lesion display moderate vascularity with signs of angiogenesis?", "Is there little to no mucin content visible within the structure?", "Are calcifications sparse or absent, with only occasional microcalcifications present in the lesion?"], "relational": ["Does the image show a lesion originating from mammary gland tissue?", "Is there evidence of a process affecting the integumentary system, specifically the breast?", "Can you identify an area composed of malignant epithelial cells that may express estrogen receptors?", "Does the image reveal invasion into the surrounding breast parenchyma or chest wall?", "Is there a mass that appears to involve or distort the overlying skin?", "Can you see a structure adjacent to subcutaneous fat or pectoralis major muscle that appears abnormal?", "Is there any indication of involvement of axillary, internal mammary, or supraclavicular lymph nodes?", "Does the image show abnormality near the internal mammary or lateral thoracic vessels?", "Is there evidence of interaction with stromal tissue, such as remodeling of the extracellular matrix?", "Can you observe a lesion whose boundaries are defined by infiltration into skin, muscle, or chest wall?", "Is there a mass that appears to extend directly into the pectoral muscles or underlying chest wall structures?"], "contexual_behavior": ["Does the image show a tumor that might increase its growth rate in response to elevated estrogen or growth factor signaling?", "Can you identify a carcinoma that could become less responsive to estrogen signaling after long-term hormone therapy?", "Is there evidence of a tumor that would show reduced hormone-driven growth if estrogen levels were suppressed or after developing resistance to hormone therapy?", "Does the image contain a neoplasm that may develop resistance to endocrine therapy following chronic exposure to anti-estrogen agents or due to genetic changes?", "Can you see features suggesting increased metastatic potential, possibly due to advanced disease or acquisition of invasive characteristics?", "Is there a tumor that might display adaptive changes to hypoxic conditions, such as those seen when a mass outgrows its blood supply?", "Does the image show a carcinoma that could decrease apoptosis in response to treatment, potentially due to upregulated anti-apoptotic pathways or impaired p53 function?", "Is there visual evidence of increased angiogenesis, possibly as a response to nutrient deprivation or hypoxic stress within a tumor?", "Can you identify a neoplasm that might reduce immune evasion mechanisms when exposed to immunomodulatory therapies?", "Does the image suggest a tumor that could increase estrogen receptor activity after menopause, perhaps due to local estrogen production or hypersensitivity to low estrogen levels?", "Is there a carcinoma that might show impaired DNA repair under genotoxic stress, possibly due to overwhelmed or mutated DNA repair pathways?", "Can you see evidence of altered metabolic activity in a tumor, such as a shift to glycolytic metabolism or adaptation to changes in the microenvironment?", "Does the image contain a neoplasm that could decrease sensitivity to chemotherapy after repeated exposure or through activation of drug efflux mechanisms?", "Is there a tumor that might increase its invasive behavior in response to inflammatory signals like cytokine release from the surrounding tissue?", "Can you identify a carcinoma that could reduce hormone receptor expression after prolonged anti-estrogen therapy or due to epigenetic modifications?", "Does the image show a tumor that might enhance survival in the presence of anti-estrogen drugs by activating alternative signaling pathways or upregulating survival proteins?", "Is there evidence of a neoplasm that could change its signaling pathways during recurrence by adopting alternative growth and survival mechanisms?", "Can you see a tumor that might increase its proliferation during pregnancy due to elevated estrogen and progesterone levels?", "Does the image suggest a carcinoma that could decrease its dependency on estrogen in advanced stages by acquiring mutations or activating alternative growth pathways?", "Is there a tumor that might alter its behavior in the presence of co-morbid metabolic disorders, such as responding to changes in insulin, glucose, or adipokine levels?"], "functions": ["Does the image show a region with evidence of uncontrolled cell proliferation and invasion into surrounding tissues?", "Can you identify an area where cells express estrogen receptors?", "Is there visual evidence of tissue invasion, such as disruption of normal tissue boundaries?", "Does the image contain features suggestive of increased cell division or evasion of growth suppressors?", "Can you see signs of estrogen-driven signaling, such as clusters of proliferating cells with hormone receptor activity?", "Is there an area where gene expression patterns might support cell survival and resistance to apoptosis?", "Does the image show degradation of the extracellular matrix or increased cellular motility?", "Can you identify regions with altered immune cell infiltration or changes in cytokine profiles?", "Is there evidence of immune evasion, such as reduced antigen presentation or the presence of immunosuppressive factors?", "Does the image suggest that cells have entered blood vessels or lymphatic channels, indicating potential for metastasis?", "Can you see signs of stromal cell recruitment, angiogenesis, or changes in the extracellular matrix composition?", "Is there evidence of tumor vascularization, such as increased blood vessel formation supported by pro-angiogenic factors?", "Does the image show features that might indicate a response to hormonal therapy or the development of resistance mechanisms?", "Can you identify areas where estrogen receptor-mediated transcription or downstream signaling cascades are likely active?", "Is there visual evidence of upregulated anti-apoptotic proteins or activated survival pathways?", "Does the image suggest increased local estrogen synthesis or altered hormone receptor expression?", "Can you see morphological changes consistent with activation of PI3K/AKT, MAPK, or estrogen receptor signaling pathways?", "Is there evidence of tissue remodeling, such as the presence of matrix metalloproteinases or remodeling enzymes leading to extracellular matrix degradation?"]}, "no_questions": {"contexual_properties": ["Does the image show any evidence of a fracture involving the base of the skull?", "Can you identify any signs of disruption in the continuity of the bones forming the floor of the cranial cavity?", "Is there a visible abnormality at the base of the cranial bones that could indicate trauma?"], "properties": ["Is there evidence of a recent traumatic injury in a patient who appears to be between 20 and 40 years old, with findings suggestive of a skull base fracture?", "Is there a visible fracture at the skull base that appears linear, or does it show comminuted or depressed features?", "Does the bone at the site of the fracture appear to have a thickness between 3 and 6 millimeters?"], "relational": ["Does the image suggest possible involvement of nerves like the olfactory, optic, oculomotor, facial, vestibulocochlear, glossopharyngeal, vagus, accessory, or hypoglossal nerves?", "Can you see any disruption involving foramina or canals such as the foramen magnum, jugular foramen, carotid canal, optic canal, or internal acoustic meatus?", "Does the image show abnormalities involving cavities or sinuses like the sphenoid sinus, ethmoid sinus, mastoid air cells, nasal cavity, or middle ear cavity?"], "contexual_behavior": ["Can you identify any abnormalities at the base of the cranial bones that could indicate trauma?", "Does the image show any evidence of a fracture involving the base of the skull?", "Does the image reveal any signs suggestive of injury to the lower part of the skull?"], "functions": ["Does the image suggest the presence of cranial nerve injury, which could manifest as sensory loss or motor impairment?", "Is there evidence of altered intracranial pressure regulation, possibly due to cerebrospinal fluid leakage or intracranial bleeding?", "Does the image reveal any features that might indicate an increased risk of central nervous system infection, such as a direct route for bacteria to reach the meninges?"]}}, "triple negative": {"yes_questions": {"contexual_properties": ["Is there a mass in the image that appears to have increased in size, suggesting unchecked cell division or progression?", "Can you identify a lesion that has decreased in size, possibly indicating a response to therapy?", "Does the image show a region with altered density that could be due to necrosis, fibrosis, or treatment effects?", "Is there evidence of a mass with central areas of necrosis, suggesting it has outgrown its blood supply or undergone cytotoxic treatment?", "Can you see a lesion with high cellularity, consistent with aggressive growth or rapid proliferation?", "Is there a mass with rare calcifications, possibly associated with prior therapy or necrotic changes?", "Does the texture of any lesion appear altered, such as becoming more fibrotic or necrotic?", "Is there a mass that appears heterogeneous, with regions of necrosis, fibrosis, and viable tissue?", "Can you identify a lesion with abnormal vascular patterns, possibly due to angiogenesis or therapy-induced vascular remodeling?", "Does the image show a mass with numerous mitotic figures, indicating high proliferative activity?", "Is there a lesion with areas of altered color, such as those caused by hemorrhage, necrosis, or treatment effects?", "Can you see a mass with cystic regions, possibly resulting from central necrosis or degeneration?", "Is there evidence of increased proliferation markers, such as high Ki-67 expression, in any lesion?", "Does the image suggest changes in the molecular composition of a mass, potentially due to progression, therapy, or clonal evolution?", "Is there a lesion with increased surrounding edema, possibly due to local inflammation or vascular leakage?"], "properties": ["Does the image show a tumor that lacks expression of estrogen, progesterone, and HER2 receptors?", "Is there a lesion present with absent or very low HER2 expression?", "Can you identify a tumor with high histological grade features?", "Does the image display cells with marked nuclear pleomorphism and scant cytoplasm?", "Is there evidence of a high mitotic rate within the tumor tissue?", "Does the tumor appear to be larger than 2 centimeters in size?", "Can you see indications of a high proliferation rate, such as an elevated Ki-67 index?", "Is there a tumor with high nuclear grade characteristics?", "Are there features suggestive of underlying TP53 or BRCA1 gene mutations in the tumor?", "Does the tissue appear pale or gray-white with visible areas of necrosis?", "Is the tumor consistent with a basal-like molecular subtype based on its appearance or marker expression?", "Can you observe moderate to high levels of necrosis within the tumor mass?", "Is there a prominent stromal component or evidence of desmoplastic reaction in the tumor?", "Does the tumor appear in a patient who is younger than typical for other breast cancer subtypes, such as around 40 to 50 years old?", "Are there signs of high expression of basal markers like cytokeratin 5/6 or EGFR in the tumor cells?"], "relational": ["Does the image show a carcinoma affecting breast tissue or the mammary gland epithelium?", "Is there evidence of a malignancy involving the axillary lymph nodes?", "Can you identify epithelial or basal-like tumor cells in the sample?", "Does the image include tissue from the breast, lymph nodes, or lung that could be examined for metastatic disease?", "Is there a tumor present that lacks visible expression of estrogen receptor, progesterone receptor, and HER2?", "Can you observe a high mitotic index or basal-like morphology in the tumor cells?", "Does the sample appear to be from a breast tumor biopsy or a lymph node biopsy?", "Is there evidence of involvement of the mammary, lymphatic, or immune systems in the pathology shown?", "Can you distinguish features consistent with basal-like, mesenchymal, immunomodulatory, or luminal androgen receptor subtypes within the tumor?"], "contexual_behavior": [], "functions": ["Does the image show a tumor with features suggestive of high proliferation or rapid cell division?", "Is there evidence of increased invasiveness or metastatic spread in any of the visible lesions?", "Can you identify a tumor that appears highly aggressive or associated with poor prognosis?", "Does the image suggest early recurrence or resistance to targeted therapies in any of the cancerous regions?", "Is there a visible indication of angiogenesis, such as increased blood vessel formation around a tumor?", "Can you see signs of immune evasion, such as upregulation of immune checkpoint molecules or altered immune cell infiltration?", "Does any tumor in the image appear to lack hormone receptor expression, potentially indicating resistance to endocrine therapies?", "Is there evidence of alternative growth pathways being utilized by any of the cancerous tissues?", "Can you identify a tumor that might initially respond to chemotherapy but shows signs of relapse or resistance?", "Is there morphological evidence of epithelial-mesenchymal transition or increased cell motility in any of the tumor cells?", "Does the tumor microenvironment show signs of stromal cell recruitment or increased inflammation?", "Are there features suggestive of enhanced drug efflux, increased DNA repair, or inhibition of apoptosis in any of the cancerous areas?", "Can you see indications of activated signaling pathways such as PI3K/AKT or MAPK that might regulate cell proliferation and survival?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see evidence of protein denaturation or degradation within the tissue?", "Can you identify cells with nuclear changes such as fading, shrinkage, or fragmentation?", "Is there evidence of cytoplasmic eosinophilia in any of the cells present?"], "relational": ["Does the image show evidence of cell death in tissues such as muscle, connective, or nervous tissue?", "Is there an area where parenchymal cells or neurons seem to have lost their normal appearance?", "Is there a contrast between areas with preserved cellular integrity and those with structural breakdown?"], "contexual_behavior": [], "functions": ["Is there evidence of disrupted blood vessels, hemorrhage, or impaired perfusion in the tissue?", "Are there features consistent with unregulated, pro-inflammatory cell death, such as cell swelling and rupture?", "Does the image suggest ongoing tissue destruction or exacerbated inflammation that could contribute to disease progression?"]}}, "negative for er": {"yes_questions": {"contexual_properties": ["Does the image show tissue in which no cells display specific nuclear staining for a hormone receptor, as would be detected by immunohistochemistry?", "Can you identify a sample where all examined cells lack visible nuclear immunoreactivity for a particular receptor?", "Is there evidence of an increased proportion of cells lacking hormone receptor expression, possibly indicating tumor progression or response to therapy?", "Does the tissue appear to have shifted from weak to completely absent receptor status, with staining intensity and percentage of positive cells falling below a diagnostic cutoff?", "Can you see signs that the concentration of a specific receptor protein is below the threshold required for a positive diagnostic result?", "Is there a loss of immunoreactivity in the tissue, suggesting absence or degradation of a hormone receptor protein?", "Does the image suggest that gene expression for a certain receptor may be silenced, for example by promoter methylation or gene deletion?", "Is there visual evidence that the receptor status has changed from positive to negative, possibly following therapy or genetic alteration?", "Can you detect a decrease in measurable receptor content to levels considered negative by biochemical or immunoassay standards?", "Does the tissue composition appear to lack detectable molecules of a specific receptor, as confirmed by molecular or immunohistochemical analysis?"], "properties": ["Does the image show malignant epithelial cells with no visible nuclear staining for a hormone receptor?", "Can you identify tumor cell nuclei with less than 1% showing positive staining in the sample?", "Is there an absence of detectable nuclear staining, or only faint background staining, in the tumor cells present?", "Does the image suggest that the concentration of a specific receptor protein is below the detection limit of the assay?", "Can you determine if the Allred or H-score for the sample would fall below the threshold for positivity?", "Is there evidence that the tissue sample would be classified as negative according to standard immunohistochemistry scoring systems?", "Does the sample appear to meet the diagnostic cutoff of less than 1% of tumor cell nuclei staining positive?", "Can you see features consistent with a breast cancer tissue sample where 20% to 30% of cases show no nuclear staining for a particular receptor?", "Is there visual evidence of high reproducibility in the assessment of receptor negativity, or do you notice any variability that might affect interpretation?"], "relational": ["Does the image show a tissue sample that could be from a breast tumor biopsy or a surgical resection specimen?", "Is there evidence of anatomical structures such as breast lobules, ductal epithelium, or tumor masses present in the image?", "Can you identify features associated with the mammary gland system or the endocrine system?", "Does the image contain epithelial tumor cells or carcinoma cells that could be evaluated for receptor status?", "Is there a region in the image, such as the breast or axillary lymph nodes, that is commonly assessed for receptor expression?", "Can you see tumor cell nuclei or glandular structures that might be analyzed for nuclear staining patterns?", "Is there an absence of nuclear staining in carcinoma cells, suggesting lack of a specific receptor expression?", "Does the image include areas where cellular morphology or nuclear staining patterns could be used to classify tissue?", "Are there any indications of related biomarkers, such as progesterone receptor or HER2/neu, that might be evaluated in the same sample?", "Can you identify metastatic sites or lymph nodes that are typically examined for receptor status in oncology?"], "contexual_behavior": ["Does the image show tumor cells that are likely unresponsive to hormone-based therapies such as tamoxifen?", "Can you identify a region where estrogen signaling is unlikely to be active due to the absence of receptor expression?", "Is there evidence of tumor proliferation that appears independent of hormonal regulation?", "Does the image suggest the presence of tumor cells that might exhibit resistance to endocrine treatments targeting estrogen pathways?", "Can you see features indicating tumor growth that would persist even in postmenopausal conditions with low estrogen levels?", "Is there a region where estrogen is unlikely to regulate gene expression or cellular behavior in breast tissue?", "Does the image suggest that anti-estrogen drugs would have limited effect on certain tumor cells present?", "Can you identify tumor areas that may display increased aggressiveness or metastatic potential under microenvironmental stress?", "Is there evidence of a tumor microenvironment with increased immune cell infiltration, suggesting altered immune response?", "Does the image show tumor regions that might be more sensitive to chemotherapy due to lack of hormone-driven survival pathways?"], "functions": ["Does the image show cells or tissues that lack detectable estrogen receptor expression?", "Can you identify areas where estrogen-mediated signaling appears to be absent?", "Is there evidence of cells that do not respond to estrogen stimulation, suggesting reduced hormone responsiveness?", "Does the image contain features indicating impaired estrogen-dependent gene transcription or cellular responses?", "Can you see signs of hormone-independent cell growth or more aggressive proliferation?", "Is there an absence of estrogen-induced transcriptional regulation affecting gene expression in the depicted cells?", "Does the image suggest resistance to endocrine therapies targeting estrogen signaling, such as tamoxifen?", "Are there visual cues consistent with a poorer prognosis or more rapid progression, as seen in certain cancers lacking estrogen receptor activity?", "Can you identify evidence of alternative growth and survival pathways being favored over estrogen-dependent ones?", "Does the image show less differentiated cellular phenotypes, possibly due to limited estrogen-driven differentiation?", "Are there features of a tumor microenvironment that appears less responsive to hormonal cues or potentially more immunogenic?"]}, "no_questions": {"contexual_properties": ["Is there evidence of altered bone shape that could be due to congenital anomaly, trauma, or an expansive lesion such as cholesteatoma?", "Does the image reveal compression of bone by an expanding mass such as a tumor, cyst, or vascular anomaly?", "Are there abnormal calcifications present that could be associated with labyrinthitis ossificans or certain tumors?"], "properties": ["Is there an object whose temperature would match core body temperature, around 37 degrees Celsius?", "Can you identify an object that appears pale yellowish-white in color?", "Is there a structure that would be expected to have a low water content, less than 10% by weight?"], "relational": ["Does the image contain a region near the internal acoustic meatus or jugular foramen?", "Does the image show a pyramid-shaped region within the temporal bone?", "Does the image show cavities or spaces like the inner ear cavity or mastoid air cells?"], "contexual_behavior": ["Does the image reveal a structure whose protective role for the facial nerve could decrease due to bone resorption from osteomyelitis?", "Is there an area where support for the internal auditory canal may be compromised by tumor growth such as vestibular schwannoma?", "Is there a structure whose barrier function against intracranial pressure changes could be compromised by bone thinning or invasive infection?"], "functions": ["Can you see a region that contains the apparatus responsible for detecting head position and maintaining balance?", "Does the image show a labyrinthine bony region that houses both auditory and vestibular apparatus, such as the cochlea and semicircular canals?", "Is there a rigid bony area that supports the cochlea and facilitates the transmission of sound vibrations?"]}}, "possible precursor lesion": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to have increased in size, possibly due to cellular proliferation or progression toward malignancy?", "Can you identify an area that has decreased in size, suggesting regression, apoptosis, or a response to treatment?", "Does any region show a change in color that could be attributed to vascular changes, altered melanin content, or hemorrhage?", "Is there a lesion with a more irregular shape, potentially indicating dysplasia or uncontrolled growth?", "Can you see a raised or thickened area that might result from hyperplasia, edema, or extracellular matrix deposition?", "Does any structure display abnormal cellular composition, such as the presence of atypical cells or metaplastic changes?", "Is there evidence of calcification within a lesion, suggesting dystrophic or metastatic mineralization?", "Can you identify an area with surface breakdown or ulceration, possibly due to necrosis or trauma?", "Does any region exhibit a change in texture, such as increased firmness or keratinization, that could be caused by fibrosis, keratinization, or edema?", "Is there a lesion showing increased cellular atypia, which might result from genetic mutations or epigenetic alterations?", "Can you see evidence of abnormal protein accumulation within a structure, possibly due to dysregulated protein synthesis or impaired degradation?", "Is there a region that appears more vascularized, potentially as a result of angiogenesis stimulated by hypoxia or growth factors?", "Does any lesion display necrotic areas, which could be due to local ischemia or rapid cell turnover?", "Can you identify increased mitotic activity in a region, suggesting upregulated proliferative signaling or cell cycle activation?", "Is there evidence of loss of normal tissue architecture, possibly due to severe dysplasia or architectural disorganization?", "Does any structure appear more infiltrative, with cells invading adjacent tissues beyond the original boundary?", "Can you see surface erosion in any area, which might result from superficial cell loss due to inflammation or trauma?", "Is there a region with increased density on imaging, potentially caused by fibrosis, calcification, or cellular accumulation?", "Does any lesion have less defined margins, possibly due to infiltration or edema causing margin blurring?", "Can you identify changes in molecular marker expression in a region, which might reflect underlying genetic or epigenetic alterations?"], "properties": ["Is there a small lesion, generally less than 1 cm in diameter, visible in the image?", "Can you identify an area that appears flat, slightly elevated, or plaque-like?", "Is there a region with a pale, whitish, or erythematous coloration compared to the surrounding tissue?", "Does the image show a thin lesion, with a thickness less than a few millimeters?", "Can you see a structure that might be composed mainly of epithelial cells, possibly with some atypical or inflammatory cells?", "Is there evidence of a mildly to moderately increased mitotic index in any area compared to adjacent normal tissue?", "Does any region display cells with an increased nuclear-to-cytoplasmic ratio relative to normal cells?", "Can you identify an area where the cells show mild to moderate atypia?", "Is there a region with a disorganized architectural pattern or loss of normal tissue polarity?", "Does the image contain a small-volume lesion, generally less than 0.5 cm\u00b3?", "Can you see evidence of cells with normal or slightly increased DNA content, or signs of aneuploidy?", "Is there a region where the proliferation rate appears higher than normal tissue but lower than what is seen in malignant lesions?", "Can you identify an area where biomarkers such as Ki-67 or p53 might be expressed at low to moderate levels?", "Does any lesion appear to have a smooth or slightly rough texture?", "Is there a region that could be classified as having mild to moderate dysplasia?", "Can you see a lesion that appears to consist of two to several cell layers?", "Is there evidence of normal or slightly increased vascularity in any area compared to surrounding tissue?", "Does the image show a region with absent or minimal keratinization, except for possible focal keratinization in squamous tissue?", "Is there a lesion whose density is similar to or slightly greater than that of the adjacent tissue?", "Can you identify an area with a smooth surface, possibly with slight irregularities or granularity?"], "relational": ["Does the image show an area arising from epithelial, glandular, or mucosal tissue that appears different from the surrounding tissue?", "Can you identify a region associated with the digestive, reproductive, or respiratory system that looks abnormal?", "Is there an abnormal area present in common sites such as the cervix, colon, esophagus, or skin?", "Does the image contain cells that resemble dysplastic epithelial cells, basal cells, or inflammatory cells within a localized region?", "Can you see a structure surrounded by a basement membrane, stroma, or adjacent normal epithelium?", "Is there a visible transition zone or interface between abnormal and healthy cells in the tissue?", "Does the image show a localized area within an organ, organ subregion, or tissue compartment that appears distinct from the rest?", "Can you identify a region that could be structurally related to benign neoplasms, hyperplastic lesions, or carcinoma in situ?", "Is there an abnormal area present in organs such as the colon, cervix, breast, or prostate?", "Does the image show a region with clearly defined lesion margins, a basement membrane boundary, or surrounding tissue demarcation?"], "contexual_behavior": ["Is there a structure in the image that could show features of increased cellular proliferation, possibly due to chronic inflammation?", "Can you identify an area that might display abnormal tissue architecture, suggesting disruption of cell polarity or adhesion after injury?", "Does the image reveal a region where new blood vessel formation is evident, potentially indicating increased angiogenic activity under hypoxic conditions?", "Is there evidence of a lesion that appears more resistant to immune cell infiltration, possibly due to immune checkpoint molecule expression or reduced antigen presentation?", "Can you see a region where the tissue appears to have decreased apoptotic activity, which might be associated with impaired p53 function or upregulated anti-apoptotic pathways?", "Is there a structure that seems to have impaired differentiation, perhaps in the context of altered hormone receptor signaling?", "Does the image contain an area that could be shifting its metabolic activity towards glycolysis, possibly as a response to oxidative stress?", "Can you identify a lesion that appears more invasive, which might be due to increased matrix metalloproteinase activity or altered cell adhesion after carcinogen exposure?", "Is there a region that shows signs of reduced cell turnover, potentially reflecting cellular senescence in aging tissue?", "Does the image show a lesion that might be surviving better in an immunosuppressed environment, possibly by evading immune detection or resisting apoptosis?", "Can you see evidence of deficient DNA repair, such as abnormal nuclear morphology, in a region that may have been exposed to mutagens?", "Is there an area in the image that appears to be secreting pro-inflammatory cytokines, possibly in response to infection or local immune activation?", "Does the image reveal a lesion that seems less responsive to growth-inhibitory signals, which could be due to inactivation of tumor suppressor pathways like TGF-beta?", "Is there a structure that appears to have lost its ability to regress, potentially due to irreversible molecular changes stabilizing an abnormal phenotype?", "Can you identify a region that may be at increased risk for malignant transformation if additional genetic or epigenetic alterations are acquired?"], "functions": ["Does the image show an area of abnormal tissue change that could indicate the early stages of disease initiation?", "Can you identify a region where genetic or epigenetic alterations might be accumulating, potentially leading to pathogenesis?", "Is there evidence of dysplasia, such as altered cell proliferation or loss of normal tissue architecture, visible in the image?", "Does the image display features consistent with tissue remodeling or signs of cellular transformation disrupting normal growth patterns?", "Can you see a region that could serve as a biomarker or target for early disease detection or screening?", "Is there a structure that might be participating in signaling pathways related to cell cycle regulation, apoptosis, or inflammation?", "Does the image reveal areas where gene expression appears altered or where normal cellular homeostasis might be disrupted?", "Can you identify regions showing signs of microenvironment modification, such as inflammation, angiogenesis, or changes in the extracellular matrix?", "Is there visual evidence of immune activation, such as the presence of infiltrating immune cells or features suggesting neoantigen presentation?", "Does the image show abnormal cell-to-cell communication or signs of local invasion into surrounding healthy tissue?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion that is encapsulated or surrounded by a fibrous capsule?", "Can you see a mass located within the integumentary, nervous, reproductive, or gastrointestinal systems?", "Is there a localized growth present in regions like the head and neck, extremities, abdomen, or pelvis?"], "contexual_behavior": [], "functions": ["Can you identify a mass that induces symptoms related to pressure on adjacent anatomical structures?", "Is there a structure in the image that appears to be growing slowly and does not invade nearby tissues?", "Is there a structure that could be altering local cellular signaling, such as by producing growth factors affecting neighboring cells?"]}}, "mutations of pik3ca": {"yes_questions": {"contexual_properties": ["Does the image show evidence of genetic alterations that increase in frequency during tumor progression?", "Can you identify features suggesting a higher prevalence of specific mutations in advanced tumors or particular cancer subtypes such as breast or colorectal cancers?", "Is there visual or molecular evidence indicating clonal expansion or dominance of certain tumor cell populations?", "Does the image suggest changes in the mutation spectrum in response to targeted therapy or environmental influences?", "Are there indications of structural alterations in proteins at known hotspot regions such as E545K or H1047R?", "Can you detect increased gene copy number or amplification events in cancer cells?", "Is there evidence of co-occurring genetic alterations, such as those involving TP53 or KRAS, within the same tumor sample?", "Does the image suggest higher gene expression levels due to amplification or transcriptional upregulation?", "Are there features consistent with metastatic tissue, as opposed to primary tumors, in certain cancer types?", "Can you observe patterns indicative of therapy resistance, such as the emergence of resistant subclones or shifts in mutation types?", "Is there evidence of increased detection of tumor-derived DNA in circulation during active disease or tumor progression?", "Does the image suggest accumulation of genetic alterations in tissue types such as breast, endometrial, or colorectal tissues?", "Are there signs of higher mutation burden in tumors with genomic instability or mismatch repair deficiency?", "Can you identify differences in the distribution of mutations across exons depending on cancer type or selective pressures?", "Is there evidence of altered phosphorylation sites affecting key residues involved in kinase activity?"], "properties": ["Does the image show evidence of genetic alterations such as missense changes, insertions, or deletions in a gene associated with the PI3K pathway?", "Can you identify nucleotide substitutions like c.3140A>G or c.1633G>A in the depicted genetic material?", "Is there a visible amino acid change corresponding to p.H1047R, p.E545K, or p.E542K in the protein sequence shown?", "Does the image suggest the presence of a mutation occurring in approximately 10-20% of certain cancers?", "Can you see alterations located specifically in exon 9 or exon 20 of a gene involved in oncogenic signaling?", "Is there evidence of structural changes affecting the helical or kinase domains of a protein in the PI3K pathway?", "Does the image indicate constitutive activation of the PI3K pathway due to a genetic alteration?", "Can you observe clustering of mutations within exon 9 or exon 20 in the genetic data presented?", "Is there a mutation hotspot accounting for over 80% of alterations in the gene depicted?", "Does the image suggest that the zygosity status of a mutation is heterozygous in a tumor sample?", "Can you identify a variant allele frequency between 10% and 50% in the tumor sample shown?", "Is there an insertion or deletion of 1 to 10 base pairs visible in the genetic sequence?", "Does the image highlight a mutation affecting codon 1047 in the gene sequence?", "Can you see evidence of a genetic variant with a high pathogenicity or oncogenic score?", "Is the reference sequence NM_006218.4 used to annotate the genetic changes in the image?"], "relational": ["Does the image show tissue from the breast, colon, uterus, or brain that could contain cells with specific genetic alterations?", "Can you identify epithelial, tumor, or endothelial cells that might exhibit changes in cell proliferation pathways?", "Is there evidence of altered PI3K-AKT signaling or mTOR pathway activity in any of the visible tissues?", "Does the image contain structures that could be part of the endocrine, nervous, reproductive, or digestive systems and potentially affected by genetic changes?", "Can you see any protein complexes, such as PI3K or mTORC1, that might interact with altered gene products?", "Is there a visible association with other genetic alterations, such as TP53 or KRAS mutations, PTEN loss, or HER2 amplification, in the depicted tissues?", "Does the image display molecular features like a modified kinase domain or phosphoinositide binding sites within any cells?", "Can you identify anatomical regions corresponding to chromosomal changes at 3q26.32 in the context of the depicted tissue?", "Is there visual evidence of cell types or structures that could be impacted by changes in the p110\u03b1 catalytic subunit?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show narrowing or plaque formation within an artery supplying the heart?", "Is there evidence of calcification within the coronary vessels?", "Are there visible changes in the intima, media, or adventitia layers of a coronary artery?"], "contexual_behavior": [], "functions": ["Does the image show evidence of narrowed arteries that could restrict blood flow to the heart muscle?", "Can you identify any features suggesting decreased elasticity or compliance in the coronary arteries?", "Is there any indication of plaque buildup or thickening of the arterial wall that could contribute to disease progression?"]}}, "gene encoding pi3k": {"yes_questions": {"contexual_properties": ["Does the image show evidence of increased gene expression in the context of cancer progression or growth factor stimulation?", "Is there a visual indication of decreased gene expression during cellular differentiation or following targeted therapy?", "Can you identify features consistent with frequent gene mutation in breast, colorectal, or endometrial tumors?", "Does the image suggest gene amplification in malignancies such as ovarian or lung cancer, possibly indicating increased oncogenic signaling?", "Is there evidence of gene deletion associated with rare genetic disorders or tumor suppressor loss?", "Can you observe abnormal methylation patterns that might be linked to tumorigenesis or epigenetic dysregulation?", "Does the image reveal alternative splicing events during embryonic development, tissue-specific expression, or within cancer cells?", "Is there a sign of altered gene copy number in the presence of genomic instability, aneuploidy, or solid tumors?", "Can you detect abnormal transcript variants resulting from splicing factor mutations or cellular stress?", "Does the image provide clues about changes in promoter activity due to transcription factor binding or epigenetic modification?", "Is there visual evidence of altered chromatin structure during cell cycle progression or in response to chromatin remodeling complexes?", "Can you identify increased mutation frequency in regions of high mutational burden or following genotoxic stress?", "Does the image show abnormal RNA levels in malignancies, metabolic disorders, or after targeted inhibition?", "Is there evidence of structural rearrangements such as chromosomal translocations, gene fusions, or complex karyotypes?", "Can you observe changes in sequence integrity that might result from DNA damage, replication errors, or mutagen exposure?", "Does the image suggest altered regulatory element binding due to enhancer or promoter mutations or in response to signaling cues?", "Is there a sign of gene hypermethylation associated with gene silencing events, certain cancers, or epigenetic therapy?", "Can you detect hypomethylation in the context of genomic instability, oncogene activation, or developmental disorders?", "Does the image indicate increased single nucleotide polymorphisms in cancer genomes or inherited susceptibility loci?", "Is there evidence of abnormal chromosomal localization due to chromosomal rearrangement, aneuploidy, or genetic syndromes?"], "properties": ["Does the image contain a representation of a DNA sequence unique to a specific isoform of a kinase involved in phosphatidylinositol signaling?", "Is there evidence of a gene with a length between 30,000 and 35,000 base pairs?", "Can you identify a chromosomal region labeled as 3q26.32, which is relevant to a catalytic subunit frequently altered in cancer?", "Does the image show any indication of gene variants such as E545K or H1047R, which are commonly associated with oncogenic processes?", "Is there a depiction of a gene with a GC content in the range of 50\u201355 percent?", "Can you see a gene structure composed of multiple exons and introns, with the number and arrangement varying by isoform?", "Is there a visual cue suggesting moderate gene expression in immune or epithelial cells?", "Does the image include a promoter region with regulatory elements like TATA boxes or transcription factor binding sites?", "Is there any indication of low to moderate methylation status in a gene, suggesting active transcription?", "Can you identify an mRNA transcript with a length of approximately 7,000 to 8,000 nucleotides?", "Does the image show a gene with about 20 to 21 exons, as seen in certain kinase-encoding genes?", "Is there a protein product depicted that functions as a catalytic subunit in a lipid kinase complex?", "Can you see a protein with a molecular weight close to 124 kilodaltons, corresponding to a p110\u03b1 subunit?", "Is there a representation of a protein with an isoelectric point between 6.5 and 7.0?", "Does the image suggest the presence of multiple transcript isoforms resulting from alternative splicing, particularly affecting catalytic or regulatory subunits?"], "relational": ["Does the image show a region that could correspond to chromosome 3, chromosome 5, chromosome 19, or chromosome 7?", "Is there a visible area that might represent a genetic locus such as PIK3CA, PIK3CB, or PIK3R1?", "Can you identify a structure that interacts with the nucleus or chromatin?", "Does the image contain features associated with transcriptional machinery?", "Is there evidence of genes located near MCF2L2, TERC, or MRAS?", "Can you see tissues or cells from the immune, nervous, or endocrine systems?", "Does the image include liver, brain, muscle, or blood tissue where this gene might be expressed?", "Is there a structure that could produce proteins like p110\u03b1, p110\u03b2, p85\u03b1, or p110\u03b4?", "Can you identify regulatory elements such as promoters, enhancers, or CpG islands?", "Does the image show cell types such as lymphocytes, neurons, hepatocytes, or epithelial cells?", "Is there a visible molecular complex that could be a transcription factor complex, RNA polymerase II complex, or chromatin remodeling complex?"], "contexual_behavior": ["Does the image show evidence of increased signaling in response to growth factor stimulation or cell proliferation?", "Is there a visual indication of reduced pathway activity that could be associated with nutrient starvation?", "Can you identify features suggestive of impaired signaling or loss of function in a cancerous context?", "Does the image contain signs of enhanced transcription or metabolic effects following insulin stimulation?", "Is there evidence of impaired downstream signaling that might be linked to a metabolic disease such as type 2 diabetes?", "Can you observe features consistent with lowered expression or reduced survival signaling during cellular aging?", "Is there a visual cue indicating modulated activity in response to oxidative stress, possibly affecting cell survival or repair?", "Does the image suggest enhanced function during immune cell activation, such as increased lymphocyte proliferation?", "Are there signs of decreased signaling that could result from the presence of a drug inhibitor targeting a specific pathway?", "Can you see features that might indicate hyperactivation of a signaling pathway due to oncogenic mutation, leading to uncontrolled proliferation?", "Is there evidence of reduced survival signaling under hypoxic conditions, suggesting impaired pathway activation?", "Does the image show increased glucose uptake or metabolic response following feeding, consistent with postprandial insulin effects?", "Are there visual features indicating reduced autophagy or altered energy management during fasting?", "Can you identify signs of dysregulated immune cell signaling or inflammation that might be associated with an inflammatory disease?", "Is there evidence of upregulated signaling during tissue repair, such as enhanced cell growth or regeneration?"], "functions": ["Is there evidence of a process where catalytic or regulatory subunits of phosphoinositide 3-kinase are being produced?", "Can you identify cellular activity that suggests the presence of PI3K/AKT/mTOR pathway activation, such as increased cell growth or protein synthesis?", "Does the image show signs of phosphatidylinositol (3,4,5)-trisphosphate generation, indicating recruitment of downstream effectors in cell signaling?", "Is there visual evidence of enhanced cell survival, possibly due to anti-apoptotic signaling or AKT phosphorylation?", "Can you observe features consistent with increased glucose uptake or glycogen synthesis, suggesting active insulin signaling pathways?", "Does the image indicate lymphocyte activation, proliferation, or migration, reflecting immune cell function regulation?", "Are there signs of cytokine production or leukocyte activity that would suggest modulation of inflammation?", "Can you identify cellular proliferation or mitogenic signaling, such as increased DNA synthesis or cell cycle entry?", "Is there evidence of apoptosis inhibition or pro-survival signaling within the cells?", "Does the image show translocation of glucose transporters to the cell membrane, indicating active insulin signaling?", "Are there features of angiogenesis, such as endothelial cell migration or proliferation, possibly mediated by VEGF signaling?", "Can you observe cellular changes associated with oncogenic signaling, increased cell survival, or resistance to apoptosis, which may relate to cancer progression?", "Is there evidence of autophagy regulation, such as changes in mTOR activity or vesicle trafficking?", "Does the image suggest integration of growth factor signals leading to cellular differentiation or determination of cell fate?", "Are there visual cues of tissue repair or regeneration, such as coordinated cell migration, proliferation, and survival during healing?"]}, "no_questions": {"contexual_properties": ["Is there a structure that seems to have lost its capsule and is infiltrating adjacent tissues, indicating invasive behavior?", "Can you see a region that appears necrotic, possibly due to insufficient blood supply or rapid expansion?", "Do you see a surface defect or ulceration, which might result from outgrowing the blood supply or invasion of overlying tissue?"], "properties": ["Can you identify an area with increased or heterogeneous vascularity, possibly due to angiogenesis?", "Can you identify a structure that could weigh anywhere from less than a gram to several kilograms, depending on its characteristics?", "Does the image suggest a region where cell division is elevated compared to surrounding tissue?"], "relational": ["Does the image show an abnormal mass originating from epithelial, connective, muscle, or nervous tissue?", "Can you observe a mass interacting with surrounding connective tissue, possibly through invasion or tissue remodeling?", "Is there a structure that appears to cross anatomical barriers such as the basement membrane, blood-brain barrier, serosal membranes, or fascia?"], "contexual_behavior": ["Is there evidence of increased production of growth factors to support proliferation and new blood vessel formation?", "Is there a mass that seems to be disrupting the normal architecture of nearby tissue, potentially suppressing local function?", "Does the image show a structure that might be resisting oxidative stress, as suggested by features indicating upregulated antioxidant defenses?"], "functions": ["Can you see a region where abnormal cell proliferation might be driven by sustained mitogenic signaling?", "Is there a visible area that could be evading immune detection, such as by lacking typical antigen presentation markers?", "Does the image show evidence of new blood vessel formation, possibly due to secretion of vascular endothelial growth factors?"]}}, "breast cancer": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any abnormality originating from the epithelial lining of ducts or lobules?", "Is there evidence of a lesion affecting the mammary ducts or lobules?", "Can you identify changes in the breast stroma that might indicate disease involvement?", "Does the image reveal any enlargement or involvement of axillary lymph nodes?", "Is there visible abnormality in the supraclavicular or internal mammary lymph nodes?", "Can you see any structure that is part of the integumentary system showing signs of disease?", "Is there a suspicious area located in the upper outer quadrant, central region, or lower inner quadrant of the breast?", "Does the image show any irregularity near the internal thoracic vein, axillary vein, or intercostal veins?", "Are there signs of disease affecting the bones, lungs, liver, or brain that could suggest metastatic spread?", "Can you see any abnormality involving the mammary glands?", "Is there evidence of disease extending to the skin, pectoral fascia, or the lateral or medial borders of the breast?", "Does the image show invasion into the pectoralis major muscle or chest wall?", "Can you identify any changes in the overlying skin that may be related to underlying pathology?"], "contexual_behavior": [], "functions": ["Does the image show a region where normal glandular architecture is disrupted or replaced by abnormal cells?", "Can you identify an area with evidence of uncontrolled cell proliferation or abnormal growth patterns?", "Is there a structure that appears to invade or extend into surrounding tissues, suggesting loss of normal boundaries?", "Does the image display signs of basement membrane degradation or extracellular matrix breakdown?", "Can you see evidence of new blood vessel formation that might suggest angiogenesis?", "Is there a region where immune cells are recruited or inflammation is present in association with abnormal tissue?", "Does the image contain features indicating altered interactions between stromal cells and abnormal cell clusters?", "Can you identify areas where the extracellular matrix appears remodeled or its composition seems altered?", "Is there visual evidence of abnormal cell clusters that could be resisting programmed cell death?", "Does the image show regions where the normal tissue is replaced by cells that might modulate hormone receptors?", "Can you see signs of abnormal mitotic activity or loss of growth control in any cell population?", "Is there a region where fibroblast activation or changes in the tumor microenvironment are apparent?", "Does the image suggest the presence of cells that may evade immune detection or suppress immune responses?", "Can you identify features that might indicate the spread of abnormal cells into blood vessels or distant tissues?"]}, "no_questions": {"contexual_properties": ["Does the image display features consistent with craniofacial malformation, such as altered or missing eyelid openings?", "Is there an absence of a cleft in the palate, indicating normal embryonic fusion?", "Can you observe a palate that is complete and shows no evidence of a developmental defect?"], "properties": ["Does the palate appear to have exposed pink or reddish mucosa?", "Is there a measurable gap in the palate that could indicate a cleft?", "Can you observe histological features such as absence of stratified squamous epithelium or muscle fibers in the affected regions?"], "relational": ["Can you see evidence that the frontonasal prominence, maxillary processes, and palatal shelves have developed without resulting in clefts?", "Can you observe the craniofacial skeletal system with no visible clefts in the palatal region?", "Is the roof of the mouth depicted as continuous, without visible gaps or separations?"], "contexual_behavior": ["Does the image suggest a reduced risk of aspiration during infancy compared to individuals with a cleft palate?", "Can you identify features that indicate normal Eustachian tube function and a lower risk of middle ear problems?", "Does the image suggest a lower risk of speech or language delays commonly linked to the presence of a cleft palate?"], "functions": ["Can you see features that would allow for unimpaired feeding and speech?", "Is there evidence of typical facial development without disruptions to the eyelid or palate?", "Can you identify facial features that suggest normal eyelid and oral function?"]}}, "negative for er and her2": {"yes_questions": {"contexual_properties": ["Does the image show a tumor sample where the absence of certain hormone and growth factor receptors could be influenced by technical assay variation or recent therapeutic intervention?", "Can you identify evidence of tumor progression that might alter the receptor status from undetectable to detectable?", "Is there a visual indication that genetic mutations or epigenetic modifications could have led to the appearance of new receptor expression in previously negative tumor cells?", "Does the sample display features suggesting therapy resistance, potentially resulting in a shift from undetectable to detectable receptor status?", "Can you observe any staining patterns that might indicate gene amplification, transcriptional activation, or cellular differentiation in tumor cells?", "Is there evidence of sampling error or tumor heterogeneity that could affect the measured absence of specific receptors in the tissue?", "Does the image suggest changes in assay sensitivity that might impact the detection of certain proteins in tumor cells?", "Can you see a decrease in the proportion of cells lacking these receptors, possibly due to clonal evolution or selective pressure from treatment?", "Is there a staining pattern that appears borderline or equivocal, potentially caused by technical artifacts or pre-analytical tissue changes?", "Does the intensity of immunohistochemical staining suggest the use of improved detection methods, antigen retrieval techniques, or possible sample degradation?", "Can you identify morphological or molecular features that might indicate acquired mutations, pathway activation, or phenotypic plasticity under treatment?", "Does the tumor composition show signs of cellular adaptation, microenvironmental influence, or metastatic spread that could affect receptor status?", "Is there visual evidence that protein levels of these receptors have increased in a previously negative sample, possibly due to tumor evolution, therapy-induced changes, or technical reassessment?"], "properties": ["Does the image show a tumor with absent or minimal estrogen receptor expression?", "Can you identify a lesion where HER2 staining is undetectable or scored as 0 or 1+ by immunohistochemistry?", "Is there evidence of low or absent progesterone receptor expression in the depicted tissue?", "Does the tumor exhibit features consistent with a high histological grade, such as grade 2 or 3?", "Can you see indications of a high Ki-67 proliferation index, suggesting more than 20% of cells are proliferating?", "Is there a region with an increased mitotic count, reflecting high cellular proliferation?", "Does the image reveal marked variation in nuclear size and shape, consistent with high nuclear pleomorphism?", "Is there a tumor mass that appears larger than 2 cm in size?", "Can you observe poorly differentiated, high-grade tumor cell morphology in the sample?", "Does the cytoplasmic staining pattern appear negative or non-specific for estrogen receptor and HER2 markers?", "Is there evidence of coarse and irregular chromatin within the nuclei of tumor cells?", "Can you identify frequent areas of tumor necrosis within the tissue?", "Does the tumor display densely packed cells, indicating high cell density?", "Are the nucleoli within tumor cell nuclei prominent and possibly multiple?"], "relational": ["Does the image show tumor cells within breast tissue that lack both estrogen receptor and HER2 protein expression?", "Can you identify a lesion in the mammary gland that would be classified as negative for both ER and HER2?", "Is there evidence of a breast tumor where neither the nuclei nor the cell membranes of the tumor cells display ER or HER2 positivity?", "Does the image contain a carcinoma in the breast that could be consistent with triple-negative breast cancer?", "Can you see a tumor sample from the mammary gland that would not express estrogen receptor or HER2 protein?", "Is there a structure in the image, possibly from a tumor biopsy, where both ER and HER2 biomarkers are absent?", "Does the image include invasive ductal carcinoma cells that are negative for both ER and HER2?", "Can you identify a breast tumor where the nuclei do not show ER staining and the cell membranes do not show HER2 staining?", "Is there a sample from the female reproductive system, specifically the breast, where both ER and HER2 are not detected?", "Does the image show a tumor in the breast or a metastatic site that lacks both estrogen receptor and HER2 expression?", "Are there tumor cells present where other biomarkers such as progesterone receptor or Ki-67 might be evaluated alongside negative ER and HER2 status?", "Can you see a lesion in the lymph nodes that could have originated from a breast tumor negative for both ER and HER2?"], "contexual_behavior": ["Does the image show a tumor that is unlikely to respond to hormone-based therapies due to lack of certain receptor expression?", "Is there evidence of a neoplasm that would not benefit from anti-ER or anti-HER2 targeted agents?", "Can you identify a tumor with features suggestive of high proliferation and aggressive growth patterns?", "Does the image depict a cancer type that may exhibit resistance to conventional chemotherapy and display basal-like characteristics?", "Is there a tumor present that is associated with a higher risk of visceral or brain metastases, as seen in certain triple-negative cancers?", "Can you see evidence of a neoplastic lesion that might display increased immunogenicity or altered antigen presentation?", "Does the image suggest a tumor with limited likelihood of regression following hormone or HER2-targeted treatment?", "Is there a neoplasm that appears to grow independently of estrogen or HER2 signaling pathways?", "Can you identify a tumor type with a higher risk of early recurrence after surgical intervention?", "Does the image show a cancer that may exhibit adaptive survival mechanisms under hypoxic conditions?", "Is there evidence of increased vascularization in a tumor that might rely on alternative pro-angiogenic pathways?", "Can you see features of a neoplasm that may evade apoptosis through non-receptor-mediated survival mechanisms?", "Does the tumor appear to have a growth rate during pregnancy that is not driven by hormonal changes?", "Is there a cancer present that could potentially respond better to immune checkpoint inhibitors due to higher immunogenicity?", "Can you identify a tumor that may rely on glycolytic metabolism and show adaptation to nutrient stress?"], "functions": ["Does the image show a tumor that lacks both estrogen receptor and human epidermal growth factor receptor 2 expression?", "Is there evidence of a breast tumor with features suggesting limited options for targeted or hormone-based therapies?", "Can you identify cancer cells that would likely not respond to drugs such as tamoxifen or trastuzumab?", "Does the image suggest a tumor with an aggressive phenotype and a higher risk of recurrence?", "Is there a visible indication of high proliferation, such as an elevated mitotic index or increased Ki-67 staining?", "Can you see features consistent with a basal-like or triple-negative phenotype, such as poor differentiation or high histological grade?", "Is there evidence of upregulated alternative signaling pathways, such as increased EGFR or basal marker expression?", "Does the tumor appear to have characteristics associated with early relapse or a greater likelihood of metastasis to visceral organs or the central nervous system?", "Are there morphological signs of mesenchymal transition or gene expression changes linked to basal-like features?", "Can you identify a tumor that demonstrates resistance to both endocrine and targeted therapies directed at ER and HER2?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Are there visible extracellular matrix components such as collagen or fibronectin present in the tissue?", "Can you identify a region that is part of the reproductive, hematopoietic, or musculoskeletal system?", "Is there a structure that could be classified as connective tissue?"], "contexual_behavior": [], "functions": ["Can you see evidence of extracellular matrix production, such as collagen or fibronectin deposition?", "Does the image show cells that could be interacting with immune cells or modulating local immune responses?", "Is there a cell population that might be creating a supportive microenvironment for tissue repair?"]}}, "the least common but molecularly most distinctive type of breast cancer": {"yes_questions": {"contexual_properties": ["Does the image show a breast lesion that appears to have increased in size, suggesting progressive tumor growth or an advanced disease stage?", "Can you identify a tumor with evidence of changes in cellular composition, such as areas that look different from typical breast tissue, indicating metaplastic transformation?", "Is there a region with unusual tissue density, possibly due to extensive stromal reaction or matrix production within a breast mass?", "Does the image display calcifications within a breast tumor, which could be associated with necrosis or dystrophic mineralization in advanced lesions?", "Is there a breast tumor that may lack typical hormone receptor expression, such as estrogen or progesterone receptors, based on associated diagnostic information?", "Can you see evidence of changes in molecular marker expression, such as altered cytokeratin or EGFR patterns, within a breast lesion?", "Does the tumor exhibit structural heterogeneity, with areas that might represent both epithelial and mesenchymal components?", "Is there abnormal cell morphology visible, suggesting early metaplastic changes within a breast mass?", "Can you identify a region with a high mitotic rate, indicating rapid proliferation or aggressive tumor growth?", "Does the image show necrotic areas within a breast tumor, possibly due to the tumor outgrowing its blood supply, especially in larger or high-grade lesions?", "Are there visible changes in color or appearance within a breast mass that could be attributed to necrosis, hemorrhage, or matrix production?", "Is there evidence of increased genetic instability, such as features consistent with tumor progression or heterogeneity in a breast lesion?", "Can you identify a breast tumor with a high proliferation index, as might be indicated by markers like Ki-67 or by features of aggressive growth?", "Does the tumor appear to invade surrounding stroma or muscle, suggesting greater invasiveness and an advanced stage?", "Is there evidence of altered protein expression, such as increased basal or mesenchymal marker expression, within a breast tumor undergoing molecular evolution?"], "properties": ["Does the image show a breast tumor with abundant extracellular mucin pools containing clusters or single cells floating within them?", "Can you identify a lesion where more than half of the tumor volume appears to be composed of mucin?", "Is there evidence of tumor cells with round to oval nuclei and scant cytoplasm suspended in mucinous material?", "Does the tumor exhibit a low to intermediate grade, most often grade 1 or 2, based on nuclear features and mitotic activity?", "Can you observe a low mitotic index, with few mitotic figures present in the tumor?", "Is there visual or immunohistochemical evidence of cytoplasmic or membranous staining for mucin proteins such as MUC1?", "Does the tumor architecture include floating clusters of cells within large mucin lakes?", "Can you identify features consistent with a diploid DNA content, suggesting a near-normal DNA ploidy?", "Is there evidence of low to moderate levels of tumor-infiltrating lymphocytes in the tumor microenvironment?", "Does the tumor show positivity for epithelial markers such as cytokeratin 7 and negativity for E-cadherin on immunostaining?", "Is there an indication of low proliferative activity, such as a Ki-67 index less than 10%?", "Can you identify a tumor with a low mutational burden and few copy number alterations based on genomic or cytogenetic analysis?", "Does the lesion appear to be approximately 2 to 3 centimeters in size?", "Is there evidence of hormone receptor positivity, such as estrogen or progesterone receptor expression, in the tumor cells?", "Does the tumor show negative or low expression of HER2/neu?", "Can you identify the presence of the ETV6-NTRK3 fusion gene or the t(12;15)(p13;q25) chromosomal translocation in the tumor?", "Is the nuclear grade of the tumor low, typically grade 1, based on nuclear morphology?", "Does the tumor display a generally stable karyotype on cytogenetic analysis?"], "relational": ["Does the image show a lesion affecting the mammary gland or breast tissue?", "Is there evidence of a tumor involving the central or peripheral parenchyma of the breast?", "Can you identify abnormalities in epithelial, glandular, or stromal tissue within the breast region?", "Is there a mass located adjacent to the pectoralis major muscle, chest wall, or skin?", "Does the image reveal involvement of axillary, internal mammary, or supraclavicular lymph nodes?", "Is there any indication that a tumor is invading the chest wall, ribs, or overlying skin?", "Can you detect the presence of signet ring cells, discohesive tumor cells, or mucin-producing cells in the tissue sample?", "Is there evidence of disease affecting terminal duct lobular units, lobules, or ducts?", "Does the image suggest a breast cancer type that is distinct from invasive ductal carcinoma, medullary carcinoma, or mucinous carcinoma?", "Are there signs of secondary involvement of the skeletal, respiratory, central nervous, or hepatic systems that could be due to metastasis from a breast lesion?"], "contexual_behavior": ["Is there evidence of a breast tumor that appears resistant to both chemotherapy and radiotherapy?", "Can you identify a breast lesion that shows features of altered metastatic behavior, such as signs of epithelial-mesenchymal transition or invasion into distant tissues?", "Does the image suggest a breast cancer with low or absent hormone receptor expression, potentially indicating impaired response to hormonal treatments?", "Is there a breast tumor that appears highly proliferative, possibly in association with hypoxic regions or activation of hypoxia-inducible factors?", "Can you see signs of increased tumor-infiltrating lymphocytes or features suggesting reduced immune evasion in a breast malignancy?", "Is there evidence of a breast cancer that may have altered signaling pathways, such as changes following targeted therapy or resistance to tyrosine kinase inhibitors?", "Does the image show a breast tumor with decreased angiogenic activity, possibly as a result of anti-angiogenic therapy or VEGF inhibition?", "Can you identify a breast lesion that appears to resist apoptosis despite evidence of DNA damage, potentially due to TP53 mutation or overexpression of anti-apoptotic proteins?", "Is there a breast tumor displaying increased invasiveness after chemotherapy, possibly associated with matrix metalloproteinase activation or epithelial-mesenchymal transition?", "Does the image suggest a shift in metabolic activity within a breast tumor, such as increased glycolysis or features consistent with the Warburg effect?", "Can you see indications of impaired DNA repair mechanisms in a breast malignancy, such as signs of genomic instability or deficiencies in homologous recombination?", "Is there evidence of enhanced immune evasion in a breast tumor, such as upregulation of PD-L1 or reduced antigen presentation?", "Does the image suggest reduction in hormone receptor expression in a breast cancer under endocrine therapy, possibly due to receptor downregulation or gene silencing?", "Can you identify a breast tumor with altered growth rate or adaptation to microenvironmental stress, such as survival under nutrient deprivation or oxidative stress?", "Is there evidence of increased stem cell-like properties in a recurrent breast tumor, suggesting enrichment for cancer stem cell populations after therapy?"], "functions": ["Does the image show a breast tumor with features suggesting high cellular heterogeneity or aggressive behavior compared to other types?", "Is there evidence of a lesion invading surrounding breast tissue, possibly through loss of cell adhesion or increased motility?", "Can you identify a tumor that appears to disrupt normal tissue architecture, indicating local tissue destruction?", "Does the image suggest the presence of a neoplasm with altered differentiation or signs of epithelial-mesenchymal transition?", "Is there a breast tumor that appears to lack influence from hormone receptor signaling pathways?", "Can you see a lesion that might be negative for estrogen, progesterone, and HER2 receptors?", "Does the tumor exhibit features consistent with rapid proliferation, possibly due to activation of pathways like PI3K/AKT/mTOR or Wnt/\u03b2-catenin?", "Is there visual evidence of a tumor microenvironment that could support immune evasion, such as increased immune checkpoint activity or immunosuppression?", "Can you identify a mass with signs of enhanced motility or matrix degradation, suggesting a propensity for metastasis?", "Does the image show increased vascularization within a breast tumor, possibly due to elevated VEGF or angiogenesis?", "Is there evidence of a lesion with abnormal cell cycle activity, potentially due to loss of tumor suppressors like p53 or RB?", "Can you see signs of increased extracellular matrix deposition or fibrosis within or around the tumor?", "Does the tumor appear to recruit surrounding stromal cells or show enhanced desmoplasia?", "Is there any indication of therapy resistance, such as heterogeneous cell populations or features suggestive of drug efflux mechanisms?", "Can you identify a tumor that might overexpress stem cell markers or show evidence of aberrant EGFR or Notch pathway activation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a pathological structure associated with the mammary gland system?", "Is there evidence of a process affecting any region of the breast, such as the upper outer quadrant or central area?", "Does the abnormality reside within a larger structure such as the breast or mammary gland?"], "contexual_behavior": [], "functions": []}}, "er-positive cancers": {"yes_questions": {"contexual_properties": ["Does the image show a tumor with features suggesting increased expression of hormone receptors in response to estrogenic stimulation?", "Is there evidence of a neoplasm that may have lost hormone receptor expression, possibly indicating progression or resistance to endocrine therapy?", "Can you identify a mass that has changed in size, which might reflect tumor growth, response to treatment, or recurrence?", "Is there a lesion that appears denser, potentially due to increased cell proliferation or expansion of stromal components?", "Does the image reveal a tumor with heterogeneous cellular composition, possibly as a result of progression or therapy effects?", "Are there areas of necrosis visible within a tumor, which could be due to rapid growth outpacing blood supply or following cytotoxic treatment?", "Can you observe changes in color within a lesion, possibly indicating altered vascularity, necrosis, or hemorrhage?", "Is there evidence of calcifications within a tumor, which may have developed due to necrosis, secretory changes, or therapy effects?", "Does the image show a mass with increased vascularity, suggesting angiogenesis associated with tumor progression?", "Are there visual signs of high proliferation, such as increased mitotic figures or markers of active cell division?", "Can you identify fibrotic tissue within or around a tumor, possibly resulting from a desmoplastic reaction or chronic inflammation?", "Is there a change in the texture of a lesion, which might indicate evolving tumor architecture or the development of fibrosis?", "Does the tumor display abnormal nuclear morphology, such as nuclear atypia, which could be associated with malignant progression or high-grade features?", "Are there features suggesting increased infiltration or invasiveness of a mass, possibly indicating progression to a higher grade?", "Can you see cystic components within a tumor, which may have formed due to necrosis, degeneration, or secretory activity?", "Is there evidence of metabolic activity changes within a lesion, potentially reflecting tumor progression, therapy response, or metabolic reprogramming?", "Does the image suggest the presence of hormone receptor heterogeneity within a tumor, possibly due to clonal evolution or therapy-induced selective pressure?", "Are there visual cues indicating altered gene expression profiles in a tumor, such as changes in morphology or heterogeneity, that might be associated with progression or resistance?"], "properties": ["Does the image show a tumor with high levels of estrogen receptor expression?", "Can you identify a mass measuring between 1 and 5 centimeters in size?", "Is there evidence of a neoplasm with a low to intermediate histological grade?", "Does the tumor exhibit a low to moderate number of mitotic figures?", "Are the cancer cells small to medium in size with uniform nuclei?", "Is there a visible indication of a low proliferation rate within the tumor?", "Does the tissue display a hormone receptor profile that is positive for estrogen receptor but negative or low for progesterone receptor and HER2?", "Is there a neoplasm with relatively few genomic mutations compared to other subtypes?", "Can you see evidence of low or negative HER2 protein expression in the tumor cells?", "Does the image reveal a nuclear grade that is low to intermediate?", "Is the Ki-67 proliferation index less than 20% in the observed tumor?", "Are there few chromosomal abnormalities present in the cancer cells?", "Do the tumor cells have moderate to scant cytoplasm with a pale staining appearance?", "Is the DNA content of the cancer cells diploid or near-diploid?", "Does the protein expression profile show high estrogen receptor and low HER2 levels?", "Is the tissue coloration under microscopy light pink to eosinophilic?", "Are more than 1%, and possibly over 50%, of the tumor cells positive for estrogen receptor?", "Do the cancer cells contain a low to moderate amount of lipid content?", "Is there minimal or no necrosis visible within the tumor tissue?", "Are calcifications rare or absent in the observed neoplasm?"], "relational": ["Does the image show a malignancy arising in glandular tissue such as that found in the breast or endometrium?", "Is there evidence of a tumor located within the reproductive or endocrine systems?", "Can you identify a mass composed of epithelial cells that might express hormone receptors?", "Does the image display involvement of lymph nodes, blood vessels, or connective tissue adjacent to a tumor?", "Is there a lesion present in the breast region or pelvic region?", "Can you see tissue that appears responsive to estrogen signaling?", "Does the image show abnormal enlargement or involvement of axillary or internal mammary lymph nodes?", "Is there any indication of metastatic spread to the bones, liver, lungs, or brain?", "Can you observe invasion of surrounding adipose tissue, muscle, or skin near a primary lesion?", "Is there a neoplastic process that could be classified as a carcinoma or a hormone receptor-positive cancer?"], "contexual_behavior": ["Does the image show a tumor whose growth rate might increase in the presence of elevated estrogen levels?", "Is there evidence of reduced proliferation in a neoplasm following the application of anti-estrogen therapies such as tamoxifen or aromatase inhibitors?", "Can you identify a cancerous lesion that may have developed resistance to hormone therapy after prolonged endocrine treatment?", "Is there a tumor that shows impaired response to endocrine treatments, possibly due to altered receptor signaling?", "Does the image suggest gene expression changes or activation of alternative growth pathways in a cancer under low estrogen conditions?", "Is there evidence of increased metastatic potential in a tumor under hypoxic conditions, possibly due to activation of hypoxia-inducible factors?", "Can you observe decreased hormone receptor activity in a neoplastic tissue during disease progression or under therapeutic pressure?", "Does the image suggest enhanced cell survival in a tumor during chemotherapy, potentially through activation of anti-apoptotic pathways?", "Is there a cancerous region that may have lost estrogen receptor signaling after prolonged anti-estrogen treatment or receptor downregulation?", "Can you identify increased angiogenesis in a tumor, possibly as a response to hypoxia or inflammation in the microenvironment?", "Is there evidence of reduced apoptosis in a neoplasm in the presence of growth factors that activate survival pathways?", "Does the tumor display altered metabolic activity, such as a shift to alternative energy sources during nutrient deprivation?", "Is there indication of increased immune evasion in a cancer during immunosuppression, potentially through modulation of immune checkpoint molecules?", "Can you observe decreased sensitivity to aromatase inhibitors in a tumor, possibly due to mutations or alternative estrogen synthesis pathways?", "Is there a change in proliferation rate of a neoplasm after menopause, potentially related to reduced systemic estrogen levels?", "Does the image suggest increased DNA repair activity in a tumor under genotoxic stress to maintain genomic stability?", "Is there evidence that a neoplasm has reduced dependence on estrogen signaling during late-stage disease, possibly through activation of alternative growth pathways?", "Can you identify enhanced invasive behavior in a tumor following epithelial-mesenchymal transition, which may promote metastasis?", "Is there a change in the response of a cancerous lesion to targeted therapies in the presence of co-mutations affecting signaling pathways?", "Does the image suggest increased hormone-independent growth in a tumor after long-term estrogen deprivation, possibly due to activation of ligand-independent receptor pathways?"], "functions": ["Does the image show a tumor that might depend on hormone signaling for its growth?", "Is there evidence of a neoplasm that could express receptors responsive to estrogen?", "Can you identify a cancerous region where cell proliferation might be driven by hormone pathways?", "Does the image suggest the presence of a tumor that could activate genes involved in growth through hormone receptor signaling?", "Is there a region where cell cycle regulation may be influenced by hormone receptor activity?", "Can you see features consistent with a tumor that might inhibit apoptosis and promote cell survival in response to hormonal cues?", "Does the image include a neoplastic area that could respond to therapies targeting hormone signaling, such as tamoxifen or aromatase inhibitors?", "Is there evidence of tumor progression that could be sustained by hormone-driven pathways?", "Can you identify a region where invasive behavior and altered cell adhesion might suggest metastatic potential influenced by hormone signaling?", "Does the image show features that could indicate immune evasion, such as a suppressed immune cell presence or altered antigen presentation in the tumor microenvironment?", "Is there a tumor area that might display resistance to endocrine therapy, possibly through changes in receptor expression or activation of alternative signaling pathways?", "Can you see evidence of a microenvironment where cytokines or growth factors may be supporting tumor growth or modulating immune responses?", "Does the image suggest altered gene expression patterns that could result from hormone receptor-mediated transcriptional regulation?", "Is there a region where cellular differentiation appears to be influenced by lineage-specific transcription factors under hormone receptor control?", "Can you identify features consistent with increased angiogenesis, possibly due to upregulation of pro-angiogenic factors in response to hormone signaling?", "Does the tumor area show signs of apoptosis regulation, such as increased cell survival that might be mediated by anti-apoptotic proteins under hormone receptor influence?"]}, "no_questions": {"contexual_properties": ["Does the image depict a rare form of twinning characterized by a single head with two faces and a shared upper body?", "Is there evidence of a congenital condition involving fusion of cranial and thoracic regions between two bodies?", "Can you identify a case where two faces are oriented in opposite directions on a shared head?"], "properties": ["Can you see a case where two heads are fused and oriented in opposite directions?", "Does the image depict a rare form of conjoined twinning with shared cranial and thoracic structures?", "Does the image show two individuals who are physically joined together?"], "relational": ["Is there evidence of common heart circulation serving both bodies?", "Is there evidence of shared central nervous system structures between two bodies?", "Can you identify two distinct faces, each with separate eyes, nose, and mouth, on a single fused cranial structure?"], "contexual_behavior": ["Does the image show two individuals who are physically joined together at the head and upper torso?", "Can you identify a case where two faces are oriented in opposite directions on a shared head?", "Is there evidence of a congenital condition involving fusion of cranial and thoracic regions between two bodies?"], "functions": ["Does the image suggest a partially or fully shared circulatory system, potentially leading to complex hemodynamics?", "Does the image show individuals with anatomical features that could lead to compromised cardiorespiratory function?", "Can you observe anatomical features indicating a shared upper digestive tract, which might complicate feeding or swallowing coordination?"]}}, "germline brca2 mutations": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of nucleotide changes such as missense, nonsense, frameshift, or splice site alterations in a gene associated with hereditary cancer risk?", "Can you identify any genetic variants located in exons 10, 11, 18, or 27 of a tumor suppressor gene?", "Is there a rare or population-specific genetic variant present in the depicted sample?", "Does the image suggest the presence of a truncated or structurally disrupted protein due to a premature stop codon?", "Can you observe a protein product that is shorter than the typical 3418 amino acids expected for the wild-type form?", "Is there evidence of amino acid changes such as Glu2856Lys, Ser1982Arg, or Trp2626Cys in the gene sequence shown?", "Does the sample display a genetic variant present in the heterozygous state?", "Is there a reduction or absence of gene expression or protein product compared to normal levels?", "Can you identify a frameshift mutation, and if so, is it more prevalent than a missense mutation in the sample?", "Does the image indicate the presence of a pathogenic variant rather than a benign one in the gene of interest?", "Is the molecular weight of the observed protein less than 384 kDa, suggesting a truncating mutation?", "Are there any large genomic rearrangements visible, accounting for a small percentage of all variants in the gene?", "Does the image show a variant in an intronic region that could affect splicing?", "Is there a mutation with a high predicted pathogenicity score, such as a truncating or frameshift variant?", "Does the sample originate from an individual in early adulthood to middle age, consistent with the typical age of onset for cancer associated with these mutations?"], "relational": ["Does the image show any tissue or organ commonly affected by hereditary cancer syndromes involving genes such as BRCA2 or BRCA1?", "Is there a visible structure that could be part of the reproductive system, endocrine system, or digestive system, which are influenced by certain inherited genetic alterations?", "Can you identify any anatomical site, such as breast, ovary, prostate, or pancreas, that is frequently associated with tumors linked to inherited mutations in DNA repair genes?", "Does the image contain tissue types like breast, ovarian, prostate, or pancreatic tissue, which may be impacted by alterations in homologous recombination repair pathways?", "Is there evidence of a structure composed of nucleated cells that could be affected by inherited mutations present in both somatic and germ cells?", "Can you see any organ that might be relevant to hereditary breast and ovarian cancer syndrome?", "Does the image include any features suggesting involvement of molecular pathways such as DNA damage response or homologous recombination repair?", "Is there a structure that could be associated with genes interacting in DNA repair, such as RAD51, PALB2, or ATM?", "Can you identify any tissue that might be relevant for assessing familial risk among first-degree relatives like parents, siblings, or offspring?"], "contexual_behavior": [], "functions": ["Does the image show evidence of impaired DNA repair or increased risk of tumor formation?", "Can you identify cells or tissues exhibiting signs of homologous recombination deficiency, such as defective repair of double-strand DNA breaks?", "Is there visual evidence of genomic instability, such as accumulation of DNA damage or chromosomal aberrations?", "Does the image display features consistent with cell cycle dysregulation or checkpoint failure, such as uncontrolled cell division?", "Can you observe any indications of reduced ability to accurately repair DNA, possibly due to homologous recombination deficiency?", "Is there evidence of increased susceptibility to cancers like breast, ovarian, or prostate cancer in the tissue sample?", "Does the image suggest a loss of tumor suppressor function, such as propagation of damaged cells or uncontrolled proliferation?", "Can you see signs of impaired cellular response to DNA damage, such as persistence of genetic errors or mutation accumulation?", "Is there visual indication of chromosomal instability, such as misrepair, chromosomal breaks, or aneuploidy?", "Does the image reveal abnormal regulation of apoptosis, allowing survival of genetically damaged cells?", "Can you identify regions of abnormal cellular proliferation that might result from defective DNA repair and checkpoint control?", "Is there evidence that the cells or tissue would be more sensitive to DNA-damaging agents, such as platinum compounds or PARP inhibitors?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure adjacent to both the endocardium and the cardiac valves?", "Does the image display tissue composed mainly of cardiac muscle cells?", "Is there a layer covered externally by the epicardium in the heart?"], "contexual_behavior": [], "functions": ["Can you see evidence of compensatory mechanisms, such as thickened muscle or structural changes, that protect the heart from overload?", "Can you identify tissue that supports oxygen delivery by maintaining effective blood flow to other organs?", "Does the image show a region that could regulate blood pressure by adjusting the force and rate of contraction?"]}}, "advanced organizing pneumonia": {"yes_questions": {"contexual_properties": ["Does the image show areas of increased tissue density within the lungs that could indicate accumulation of fibrous tissue and cellular debris?", "Can you identify regions of increased opacity on imaging that might result from alveolar spaces being filled with granulation tissue and exudates?", "Is there evidence of fibrotic changes or remodeling in the lung parenchyma, suggesting replacement of normal tissue by fibrous connective tissue?", "Does the image reveal any signs of lung volume loss, such as contraction of the parenchyma, which could be due to fibrosis and scarring?", "Are there regions of consolidation visible, where alveolar spaces appear filled with organizing exudate and granulation tissue?", "Can you observe any areas where the lung tissue appears stiffer or less elastic, possibly due to replacement by fibrotic tissue?", "Is there visual evidence of abnormal cellular composition, such as infiltration of inflammatory or fibroblastic cells in the alveolar or interstitial spaces?", "Do you see airspaces that appear to be filled with granulation tissue, consistent with the organization phase of a disease process?", "Is there architectural distortion of the lung visible, such as disruption of normal structure due to fibrosis and scarring?", "Does the image display a reticular pattern, which could be a sign of interstitial fibrosis and thickening?", "Are there indications of decreased gas exchange surface area, such as obliteration of alveolar spaces by fibrous tissue?", "Can you identify a patchy appearance on radiographs, where areas of consolidation are interspersed with unaffected lung tissue?", "Is there evidence of increased inflammatory cell infiltration in the lungs, suggesting an active inflammatory phase?", "Do the lungs appear less compliant or more rigid, potentially due to accumulation of fibrotic tissue and reduced elasticity?", "Are there persistent opacities visible despite signs of treatment, which might indicate established fibrotic changes?"], "properties": ["Does the image show areas of patchy consolidation or ground-glass opacity within the lungs?", "Can you identify bilateral regions with perilobular patterns?", "Is there evidence of dense consolidation or fibrotic bands in the lung tissue?", "Do you see multifocal lesions with a subpleural or peribronchial distribution?", "Are there visible bands within the lung that appear to be 1 to 3 millimeters thick?", "Does the image show extensive consolidation involving multiple lobes?", "Can you observe patchy, non-uniform involvement of the alveoli?", "Is there a region of the lung that appears pale gray or tan in color?", "Do you see signs of increased lung tissue density, possibly in the range of 0.4 to 0.6 grams per cubic centimeter?", "Is there evidence of increased water content in the lung tissue, suggesting more than 80% by weight?", "Can you identify areas that might contain fibroblasts, myofibroblasts, macrophages, or lymphocytes?", "Are there regions where the protein concentration in alveolar exudate could be greater than 3 grams per deciliter?", "Does the image suggest the presence of 5 to 15 fibroblastic foci per low-power field in a biopsy sample?", "Is there any indication of turbid bronchoalveolar lavage fluid with increased cellularity?", "Can you infer a slightly acidic pH, around 6.8 to 7.0, in the affected lung tissue?", "Does the image suggest reduced oxygen saturation, possibly below 92% on room air?", "Are there visual cues that might correspond to elevated inflammatory markers such as C-reactive protein or erythrocyte sedimentation rate?", "Does the pattern of lung involvement suggest a duration of symptoms between 4 and 8 weeks prior to diagnosis?"], "relational": ["Does the image show any abnormalities in the respiratory system?", "Can you identify changes in the distal airspaces or subpleural regions of the lung?", "Is there evidence of altered alveolar walls, bronchioles, or interstitium?", "Does the image reveal any abnormalities in alveolar or interstitial tissue?", "Are there visible changes involving terminal or respiratory bronchioles?", "Can you detect the presence of cells such as fibroblasts, macrophages, or lymphocytes within lung lesions?", "Is there any indication of alveoli filled with granulation tissue or inflammatory cells?", "Does the image suggest excessive proliferation of fibroblasts or increased collagen deposition in lung tissue?", "Are pulmonary capillaries or small arterioles seen near areas of abnormality?", "Can you observe any interaction between affected lung regions and the pleura or adjacent bronchi?"], "contexual_behavior": [], "functions": ["Does the image show evidence of impaired lung function, such as reduced respiratory efficiency or abnormal lung appearance?", "Can you identify areas where inflammation or fibrosis might be present within the lung tissue?", "Is there visual indication of alveolar spaces being filled or replaced, potentially hindering gas exchange?", "Does the image reveal signs of reduced oxygen and carbon dioxide diffusion, such as thickened or consolidated regions?", "Can you observe features suggesting decreased lung compliance or restrictive ventilatory patterns?", "Is there evidence of abnormal tissue remodeling, such as excessive fibroblast proliferation or extracellular matrix deposition?", "Does the image display granulation tissue plugs within bronchioles or alveolar ducts that could contribute to airway obstruction?", "Are there visible signs of chronic inflammation or immune cell accumulation in the lung parenchyma?", "Can you see areas where normal alveolar structure is lost and replaced by fibrotic tissue?", "Is there indication of impaired alveolar ventilation or thickened alveolar-capillary membranes that might result in reduced blood oxygenation?", "Does the image suggest ongoing fibroproliferation or collagen deposition consistent with pulmonary fibrosis?", "Are there features indicating impaired mucociliary clearance, such as airway inflammation or obstruction by debris?", "Can you identify patchy regions of consolidation or fibrosis that could disrupt ventilation-perfusion matching and cause regional hypoxia?", "Is there visual evidence of decreased lung elasticity or stiffening due to fibrotic changes?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show a person with their head extended backward at an angle between 15 and 30 degrees?", "Can you observe the lower jaw protruding 5 to 10 millimeters in front of the upper front teeth?", "Is the distance between the upper and lower front teeth (inter-incisal distance) between 35 and 50 millimeters?"], "relational": ["Are there visible features indicating involvement of the musculoskeletal or nervous systems in the depicted posture?", "Does the image suggest stretching or repositioning of cervical muscles due to the head's tilt?", "Does the image reveal the pharyngeal or nasal cavities due to the mouth being open?"], "contexual_behavior": [], "functions": ["Is there a posture that might indicate adaptation to neurological or musculoskeletal deficits?", "Is there a posture in the image that could help maintain an open airway?", "Does the image depict a position that could straighten the upper airway and improve airflow or bolus passage?"]}}, "er-positive carcinomas": {"yes_questions": {"contexual_properties": ["Is there a lesion in the image that appears larger, suggesting recent cell proliferation or possible estrogen stimulation?", "Can you identify a mass that appears smaller, potentially indicating a response to hormonal or chemotherapeutic treatment?", "Does the image show a tumor with varying cellular composition, which might reflect progression or response to therapy?", "Is there a region that appears denser, possibly due to increased tumor cell proliferation or expansion of stromal tissue?", "Can you see an area of decreased density, which could be the result of necrosis, effective therapy, or cystic degeneration?", "Does the image reveal a tumor with features suggesting increased estrogen receptor activity, such as in early tumorigenesis or under hormonal influence?", "Is there evidence of reduced estrogen receptor expression, possibly following prolonged anti-estrogen therapy or tumor dedifferentiation?", "Can you observe a change in color within a mass, which might indicate hemorrhage, necrosis, or altered vascularity?", "Is there a region within a tumor that appears necrotic, possibly due to rapid growth outpacing blood supply or cytotoxic treatment?", "Does the image show increased vascularization within a lesion, suggesting angiogenesis in an advanced or aggressive tumor?", "Is there a mass that appears to have lost hormone receptor positivity, potentially due to progression, dedifferentiation, or therapy resistance?", "Can you identify areas of calcification within a tumor, which may result from necrosis, secretory activity, or dystrophic processes?", "Does the lesion display an increased number of mitotic figures, suggesting high proliferation or a higher tumor grade?", "Is there evidence of structural heterogeneity within a tumor, possibly reflecting genetic instability or histological variation?", "Can you see cystic changes within a mass, which might be due to necrosis, degeneration, or secretory activity?", "Does the image show increased expression of proliferation markers such as Ki-67, indicating active tumor growth or high-grade features?", "Is there a tumor with infiltrative borders, suggesting invasive characteristics and tissue degradation?", "Can you observe changes in the texture of a mass, possibly due to fibrosis, necrosis, or cystic transformation?", "Does the lesion exhibit fibrotic stroma, which could be a result of tumor-stroma interaction or chronic inflammation?", "Is there evidence of altered molecular marker levels within a tumor, potentially reflecting progression, therapy response, or genetic changes?"], "properties": ["Does the image show a tumor with cells that have round to oval nuclei and moderate amounts of cytoplasm?", "Is there a mass present that measures approximately 2 to 3 centimeters in diameter?", "Can you identify a neoplastic area with low to intermediate nuclear grade?", "Does the tumor exhibit a low to moderate mitotic index, suggesting limited cell proliferation?", "Is there evidence of high nuclear positivity for estrogen receptor expression in the tumor cells?", "Can you observe areas where progesterone receptor expression is positive, though possibly variable?", "Does the tissue lack or show low levels of HER2 expression?", "Is the Ki-67 proliferation index in the tumor low to moderate, typically under 20%?", "Do you see features consistent with invasive ductal carcinoma of no special type?", "Is there any indication of chromosomal gain at 1q or loss at 16q in the tumor cells?", "Does the tumor appear to have diploid or near-diploid DNA content?", "Are the cytoplasmic regions of the tumor cells moderate in amount and possibly eosinophilic in appearance?", "Is the tumor cell density moderate compared to other breast cancer subtypes?", "On gross examination, does the tissue appear tan to white in color?", "Can you identify glandular or tubular architectural patterns within the tumor?", "Does the tumor tissue show generally low lipid content?", "Is there a high level of estrogen receptor protein expression with variable levels of other biomarkers?", "Is mucin production infrequent or absent in the tumor?", "Does the neoplastic tissue display minimal or no necrosis?", "Is the water content of the tumor tissue similar to that of other soft tissues, around 70% by weight?"], "relational": ["Does the image show a lesion affecting glandular epithelial tissue, such as that found in the breast?", "Is there a structure present that could be part of the reproductive or endocrine systems?", "Can you identify a region containing estrogen receptor-positive epithelial cells?", "Does the image include areas adjacent to adipose tissue, connective tissue, or ducts within a glandular organ?", "Is there an abnormality located in the breast or thoracic region?", "Can you see a mass arising from or located within the mammary gland?", "Does the image display any involvement of axillary or internal mammary lymph nodes?", "Is there evidence of invasion into the chest wall, lungs, liver, or bones?", "Can you identify any structures that might facilitate spread via lymphatic or blood vessels?", "Are there tissues such as stroma, adipose tissue, or connective tissue surrounding a suspicious lesion at the primary site?"], "contexual_behavior": ["Does the image show a tumor whose proliferation could increase in response to elevated estrogen levels?", "Is there evidence of a carcinoma that might reduce its growth following anti-estrogen therapy such as tamoxifen administration?", "Can you identify a tumor that could become less responsive to hormone therapy after prolonged treatment?", "Does the image suggest increased metastatic potential in a tumor under hypoxic conditions?", "Is there a carcinoma that may display altered gene expression as a result of adaptation to ongoing hormone blockade?", "Can you observe features consistent with decreased apoptosis in the presence of activated survival pathways like PI3K/AKT?", "Does the tumor exhibit increased angiogenesis, suggesting new blood vessel formation during progression?", "Is there evidence of reduced hormone receptor activity in a tumor after long-term exposure to agents like tamoxifen?", "Can you see signs of increased cell cycle progression in a tumor that might be exposed to high estrogen states?", "Does the image indicate impaired DNA repair mechanisms in a tumor under oxidative stress?", "Is there evidence of altered immune evasion strategies in a tumor during immunosuppression?", "Can you identify a carcinoma that appears less dependent on estrogen signaling, possibly due to activation of alternative growth pathways in advanced disease?", "Does the tumor show signs of increased resistance to chemotherapy following failure of hormone-based therapies?", "Is there evidence of metabolic adaptation in a tumor, such as a shift to alternative energy sources under nutrient deprivation?", "Can you observe decreased proliferation in a tumor that might be associated with reduced systemic estrogen, such as after oophorectomy?", "Does the image suggest increased local invasion in a tumor following loss of cell-cell adhesion molecules like E-cadherin?", "Is there a carcinoma that may have altered response to targeted therapies due to the acquisition of new genetic mutations?", "Can you see evidence of reduced estrogen receptor expression in a tumor, possibly due to epigenetic modifications?", "Does the tumor appear to secrete more pro-inflammatory cytokines, indicating a more inflammatory microenvironment during progression?", "Is there evidence of decreased sensitivity to aromatase inhibitors in a tumor from a postmenopausal woman, possibly due to resistance mechanisms or activation of alternative pathways?"], "functions": ["Does the image show a tumor that could be dependent on hormone signaling for its growth?", "Is there evidence of a carcinoma that might express receptors responsive to estrogen?", "Can you identify a tumor that could activate cell proliferation and survival pathways in response to hormonal cues?", "Is there a neoplastic structure that may regulate gene expression through receptor-mediated DNA binding?", "Does the image contain a carcinoma that could be sensitive to therapies targeting estrogen signaling, such as tamoxifen or aromatase inhibitors?", "Is there a tumor whose growth might be influenced by changes in hormonal levels?", "Can you see evidence of a neoplasm that may evade immune detection by altering antigen presentation or creating an immunosuppressive environment?", "Is there a tumor that could contribute to progression and metastasis via hormone-driven proliferation and invasion mechanisms?", "Does the image show a carcinoma that might interact with stromal or immune cells, or remodel the extracellular matrix within the tumor microenvironment?", "Can you identify a neoplastic structure that may develop resistance to hormone therapy through receptor mutation or activation of alternative pathways?", "Is there evidence of local tissue invasion potentially mediated by upregulation of proteases or changes in cell adhesion molecules?", "Does the tumor appear to impact cell cycle regulation, possibly through increased expression of cyclins in response to hormonal signals?", "Can you see features suggesting increased angiogenesis, such as enhanced vascularization, that could be driven by pro-angiogenic factors in response to estrogen?", "Is there a carcinoma that might modulate apoptosis by increasing anti-apoptotic gene expression through hormone receptor signaling?"]}, "no_questions": {"contexual_properties": ["Can you observe any changes in the distribution of bright spots that might suggest disease progression or recurrence?", "Does the image show an increased number of small, bright spots that could be associated with ductal carcinoma in situ or a benign proliferative process?", "Can you identify clusters of bright spots that could indicate malignancy or a proliferative lesion?"], "properties": ["Are there several dozen or fewer bright, punctate or amorphous structures visible?", "Can you see one to three distinct clusters of high-density, radiopaque spots?", "Is there evidence of clustered, linear, or segmental arrangements of small, dense spots?"], "relational": ["Can you identify any bright spots in regions such as the upper outer quadrant or subareolar area of the breast?", "Are there visible features within the ductal epithelium or lobular stroma that differ in density from surrounding fibroglandular tissue?", "Do you observe any patterns of bright spots that seem to originate within ductal structures or lobular units?"], "contexual_behavior": ["Is there any indication that the image is from a high-risk patient under increased surveillance, such as the presence of multiple sequential images or targeted views?", "Can you see breast implants that might obscure or mask underlying small bright deposits, making their identification more difficult?", "Can you observe tissue changes or fibrosis that might be consistent with prior radiation therapy and could obscure small bright deposits?"], "functions": ["Is there a region that could be localized for targeted sampling in a diagnostic procedure such as a biopsy?", "Does the image show changes that might be used to evaluate response to therapy or treatment?", "Is there evidence of patterns or distributions that could help in recognizing malignant lesions?"]}}, "flow cytometry": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show an instrument or setup that requires a sample volume between 100 and 500 microliters?", "Can you identify a system capable of detecting particles as small as 0.2 micrometers and as large as 50 micrometers?", "Is there evidence of a device sensitive enough to detect fluorescent signals corresponding to as few as 10 to 100 molecules of equivalent soluble fluorochrome?", "Does the image include equipment that can measure up to 40 different parameters at once?", "Can you see an apparatus that operates with a flow rate between 10 and 60 microliters per minute?", "Is there a system present that can distinguish cell populations differing by only 1 to 2% in fluorescence intensity?", "Does the image show lasers or components that might emit light in the range of 355 to 640 nanometers?", "Can you identify a detection system with a dynamic range spanning 10,000- to 1,000,000-fold in fluorescence signal?", "Is there any indication that the analysis requires a minimum cell concentration of about 1 \u00d7 10^5 cells per milliliter?", "Does the setup suggest that a typical run would last between 5 and 30 minutes depending on the sample size?", "Can you see instrumentation capable of forward scatter measurements with a coefficient of variation less than 5%?", "Is there evidence of a method that can detect rare cell populations at frequencies as low as 0.01% of total events?", "Does the environment or setup suggest operation at room temperature, specifically between 20 and 25 degrees Celsius?", "Is there a system that appears to collect between 10,000 and 1,000,000 events during a standard experiment?", "Can you identify a measurement system capable of quantifying fluorescence intensities from 10^1 to 10^6 arbitrary units?"], "relational": ["Does the image show a biological sample that could be analyzed for cell surface markers or intracellular proteins?", "Is there a specimen present that might originate from peripheral blood, bone marrow, or lymph node aspirate?", "Can you identify a tissue or fluid that could provide cells from the immune, hematopoietic, or lymphatic systems?", "Does the image contain cells such as lymphocytes, monocytes, granulocytes, or stem cells?", "Is there a visible anatomical source like blood, bone marrow, lymph nodes, or spleen that could be used for cellular analysis?", "Can you see a sample that could be processed as whole blood, bone marrow aspirate, or lymphoid tissue?", "Is there evidence of hematopoietic tissue that could be analyzed for blood cell populations or leukemic cells?", "Does the image include a body fluid such as cerebrospinal fluid, pleural effusion, or ascitic fluid that could be suitable for cellular analysis?", "Can you identify cells or structures that might express CD antigens, immunoglobulins, or intracellular cytokines?", "Is there a compartment such as peripheral circulation, bone marrow cavity, or a lymphoid organ represented in the image?"], "contexual_behavior": [], "functions": ["Does the image show a technique used to analyze the physical or chemical characteristics of cells or particles?", "Is there evidence of a method that distinguishes different cell types using fluorescently labeled antibodies?", "Can you identify a process that assesses immune cell function by measuring cytokine production or activation markers?", "Does the image depict a way to measure cell proliferation using DNA-binding dyes or nucleotide analogs like BrdU or EdU?", "Is there a method present that detects cell surface markers through fluorescently conjugated antibodies?", "Can you see an approach that evaluates cell viability using dyes that differentiate live from dead cells based on membrane integrity?", "Does the image include a technique that analyzes cell cycle phases by quantifying DNA content with fluorescent dyes?", "Is there a process for detecting apoptosis using markers such as Annexin V binding or propidium iodide staining?", "Can you identify a method that quantifies intracellular proteins by permeabilizing cells and staining with fluorescent antibodies?", "Does the image show a way to monitor disease progression through longitudinal analysis of cell populations and marker expression?", "Is there evidence of a diagnostic approach for hematological disorders by identifying abnormal cell populations or immunophenotypes?", "Can you see a method that monitors response to therapy by tracking changes in cell populations or marker expression before and after treatment?", "Does the image depict a technique for detecting rare cell populations using high-throughput analysis or sensitive gating strategies?", "Is there a process present that facilitates immune functional assays by measuring cytokine production, degranulation, or proliferation at the single-cell level?"]}, "no_questions": {"contexual_properties": ["Does the image show a mass that has become firmer, possibly due to clot organization and formation during the subacute phase?", "Is there a lesion whose color changes from red to yellow or green, indicating hemoglobin breakdown and bilirubin formation?", "Is there evidence of calcification within a swelling, suggesting chronicity and incomplete blood resorption?"], "properties": ["Is there evidence of a subperiosteal accumulation that might contain clotted blood and plasma?", "Is there a swelling whose protein content would be similar to that of plasma, approximately 60\u201380 grams per liter?", "Does the image show a lesion whose density and water content are similar to those of blood?"], "relational": ["Is there evidence of a lesion that is contained by the periosteum and does not extend beyond the boundaries of an individual cranial bone?", "Is there a swelling located between the periosteum and the skull bone, but not involving the more superficial layers of the scalp?", "Is there a collection located in the subperiosteal space of the scalp?"], "contexual_behavior": ["Does the image show a scalp swelling that has persisted for several weeks, raising the risk of calcification due to delayed resolution?", "Does the image show an extensive scalp swelling or associated cranial injuries that could contribute to increased intracranial pressure?", "Is the newborn premature, with a scalp swelling that appears to be resolving slowly, possibly due to immature metabolic or resorptive processes?"], "functions": ["Does the image suggest activation of fibroblasts or deposition of extracellular matrix in a healing scalp lesion?", "Can you identify an area where phagocytosis or tissue remodeling processes may be active?", "Is there evidence of a collection between the periosteum and skull that might cause local pressure?"]}}, "histologic features": {"yes_questions": {"contexual_properties": ["Does the image show areas where there is an increased number of cells, which could be seen in neoplastic growth, inflammation, or tissue regeneration?", "Can you identify regions with evidence of tissue death, as might occur in ischemia, infection, or toxic injury?", "Are there cells with abnormal shapes that could suggest dysplasia, malignancy, or a genetic disorder?", "Is there an increase in fibrous tissue, possibly indicating chronic inflammation, tissue injury, or a fibrotic process?", "Do you observe infiltration by inflammatory cells, which may be present in acute or chronic inflammation or during an immune response?", "Is there visible fluid accumulation in the tissue, suggesting edema due to inflammation, injury, or vascular leakage?", "Can you see deposits that might represent calcification, as found in degenerative diseases, chronic inflammation, or metabolic disorders?", "Is there a disruption or loss of the normal tissue architecture, which could be associated with malignancy, severe injury, or advanced inflammation?", "Are there numerous mitotic figures, indicating rapid cell proliferation as seen in neoplasms or regenerative processes?", "Do you observe areas of tissue shrinkage or reduction in size, which may suggest atrophy from disuse, denervation, or malnutrition?", "Is there evidence of enlarged cells, possibly reflecting hypertrophy due to increased workload, hormonal effects, or compensatory mechanisms?", "Are there regions with unusual staining patterns that might be linked to metabolic storage diseases, infections, or neoplastic changes?", "Can you identify fat accumulation within cells, as seen in steatosis, metabolic syndrome, or lipid storage disorders?", "Is there evidence of bleeding within the tissue, such as hemorrhage from trauma, vascular injury, or a bleeding disorder?", "Do you see amorphous deposits that could represent amyloid, as found in amyloidosis, chronic inflammatory diseases, or certain neoplasms?", "Are there cells displaying atypical features, which may be indicative of dysplasia, malignancy, or viral infection?", "Can you find multinucleated cells, which might be present in granulomatous inflammation, viral infections, or some tumors?", "Is there an increased amount of extracellular matrix, suggesting fibrosis, tissue repair, or chronic inflammation?", "Do you observe loss of polarity in epithelial layers, which could be a sign of epithelial dysplasia, carcinoma, or tissue disorganization?", "Are there cells with vacuoles in their cytoplasm, possibly indicating cellular injury, a metabolic disorder, or toxic exposure?"], "properties": ["Does the image show cells with distinct sizes or shapes that can be visually assessed?", "Can you identify patterns of cellular arrangement such as sheets, nests, glands, or cords?", "Is there variation in cell size, ranging from small to large, visible in the tissue?", "Do the nuclei of the cells appear round, oval, or elongated?", "Can you observe cytoplasmic staining patterns such as eosinophilic, basophilic, or clear cytoplasm?", "Is it possible to estimate the nuclear-to-cytoplasmic ratio as low, moderate, or high in the cells present?", "Does the image reveal a low, moderate, or high mitotic index based on visible mitotic figures?", "Is there evidence of cellular pleomorphism, either minimal, moderate, or marked, in the tissue?", "Can you detect areas of necrosis, whether absent, focal, or extensive?", "Is the chromatin pattern in the nuclei evenly distributed, clumped, or vesicular?", "Does the tissue show any degree of fibrosis, such as absent, mild, moderate, or severe?", "Can you assess the density of inflammatory cells as sparse, moderate, or dense?", "Is the overall tissue organization well-organized or disorganized?", "Do you see variable amounts of extracellular matrix in the tissue section?", "Can you estimate the vascular density as low, moderate, or high based on visible blood vessels?", "Is there evidence of calcification, either absent, focal, or extensive, in the tissue?", "Does the tissue section display a pink to purple coloration consistent with standard H&E staining?", "Can you identify glandular formation as absent, focal, or prominent in the tissue?", "Is there mucin present, and if so, is it absent, scant, or abundant?", "Do you observe keratinization, and is it absent, focal, or extensive in the epithelial areas?"], "relational": ["Does the image display tissue types such as epithelium, connective tissue, muscle, or nervous tissue that can be distinguished by their microscopic characteristics?", "Can you identify regions belonging to the respiratory, gastrointestinal, or integumentary systems based on their unique microscopic patterns?", "Are there cells present that resemble neurons, adipocytes, fibroblasts, or epithelial cells as seen under high magnification?", "Does the image show anatomical structures like glands, blood vessels, or alveoli that are defined by their microscopic appearance?", "Can you observe distinct layers such as mucosa, submucosa, muscularis, or serosa within the tissue sample?", "Is there evidence of organized cellular arrangement, extracellular matrix composition, or structural layering visible in the specimen?", "Does the image contain organs such as the liver, kidney, or skin that can be identified by their microscopic architecture?", "Are structural components like basement membranes, collagen fibers, or capillaries visible in the tissue section?", "Can you see regions corresponding to the brain, heart, or lungs that are identifiable by their microscopic features?", "Are microscopic structures such as nuclei, cytoplasm, or intercellular junctions apparent in the image?"], "contexual_behavior": ["Does the image show evidence of increased cellular proliferation, such as a high number of dividing cells, which might be seen in rapidly growing tumors?", "Is there a region where tissue repair appears impaired, with signs like persistent inflammation or incomplete epithelial coverage, as might be found in chronic wounds or non-healing ulcers?", "Can you identify areas with reduced leukocyte infiltration or minimal inflammatory cells, which could indicate immunosuppression or the effects of steroid therapy?", "Does the image reveal increased collagen deposition or disrupted tissue architecture, suggesting fibrosis as seen in chronic liver disease or pulmonary fibrosis?", "Is there a noticeable reduction in apoptotic bodies or increased cell survival, which could be characteristic of malignancy or tumor resistance?", "Are there regions with enhanced infiltration of immune cells such as neutrophils, lymphocytes, or macrophages, consistent with acute infections or abscess formation?", "Can you observe cellular swelling, increased capillary density, or other adaptive changes that might indicate chronic hypoxia or hypoxic injury?", "Is there a visible reduction in new blood vessel formation or persistent tissue hypoxia, which could suggest impaired angiogenesis as seen in ischemic conditions?", "Does the image display widespread cell death, loss of tissue structure, or cellular debris, which are features of necrosis in infarction or severe trauma?", "Are there disorganized tissue patterns or atypical cell types that might indicate abnormal differentiation, as seen in congenital malformations or dysplasia?", "Can you see decreased capillary density or thinning of vessel walls, which are typical of reduced vascularization in aging tissues?", "Is there evidence of extracellular amyloid plaques or Congo red positivity, suggesting increased amyloid deposition as found in neurodegenerative diseases?", "Does the image show disrupted epithelial lining, increased mucosal permeability, or inflammatory infiltrates, which could indicate impaired barrier function in inflammatory bowel disease?", "Are there changes in gland size, secretory activity, or cellular morphology that might reflect altered glandular secretion in endocrine disorders?", "Can you identify excessive collagen deposition and replacement of normal tissue with scar tissue, which are signs of increased fibrosis after chronic inflammation?", "Is there nodular regeneration surrounded by fibrous septa and loss of normal tissue architecture, suggesting reduced regenerative capacity as seen in cirrhotic liver?", "Does the image show edema, eosinophil infiltration, or degranulation of mast cells, which are features of acute allergic reactions?", "Are there areas with loss of myelin sheaths, presence of macrophages, or axonal damage, indicating impaired myelination in demyelinating diseases?", "Can you observe numerous mitotic figures or atypical cell divisions, which are indicative of increased mitotic activity in high-grade malignancies?", "Does the image reveal cellular swelling, vacuolization, or loss of tissue organization, which could be signs of toxic exposure or chemical injury?"], "functions": ["Does the image display patterns that reveal the architecture or organization of tissue?", "Can you identify evidence of specific cellular compositions within the tissue shown?", "Is there any indication of pathological changes such as fibrosis or necrosis?", "Does the image show signs of cellular proliferation, differentiation, or apoptosis?", "Can you observe alterations suggestive of disease progression, like cellular atypia?", "Is there visual evidence of new cell growth or matrix deposition indicating tissue regeneration?", "Does the tissue exhibit features of leukocyte infiltration or edema, suggesting inflammation?", "Can you identify changes in the extracellular matrix or cellular organization that might indicate tissue remodeling?", "Is there anything in the image that could provide insight into tissue function or cellular interactions?", "Are there visible signs of cellular responses to injury, such as necrosis, apoptosis, or reactive changes?", "Can you detect features associated with tissue repair, like granulation tissue or re-epithelialization?", "Does the image show abnormal cellular activity, such as dysplasia, hyperplasia, or increased mitotic figures?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a region where the stroma appears edematous and hypocellular?", "Does the image display tissue with diffuse swelling of villi and no visible blood vessels?", "Is there an object that could weigh between 50 and 200 grams based on its size and appearance?"], "relational": ["Does the image show abnormal proliferation of trophoblastic tissue within the uterine cavity?", "Is there a lesion located specifically within the uterine cavity that interacts with maternal tissues like the endometrium?", "Is there involvement of the fallopian tubes or cervix by an abnormal intrauterine process?"], "contexual_behavior": [], "functions": ["Is there a structure present that indicates the absence of embryonic or fetal development within the gestational sac?", "Does the image show evidence of abnormal growth characterized by excessive proliferation of trophoblastic tissue?", "Is there visual evidence of a uterine enlargement that seems disproportionate for the expected gestational age?"]}}, "gene expression profiling": {"yes_questions": {"contexual_properties": ["Does the image provide evidence of increased gene activity following cellular activation or exposure to stimulatory factors?", "Can you identify regions where gene activity appears suppressed after treatment or inhibitory signals?", "Is there visual indication of altered gene patterns associated with disease states such as cancer or infection?", "Does the image suggest upregulation of specific genes in response to environmental stress or signaling molecules?", "Can you observe areas where gene activity is downregulated due to drug treatment or gene silencing interventions?", "Is there evidence of changes in gene signatures under stress conditions like hypoxia or oxidative stress?", "Does the image reveal abnormal transcript levels that could be linked to genetic mutations or chromosomal abnormalities?", "Can you detect differential gene expression by comparing tumor and normal tissue regions?", "Is there a visible shift in gene expression patterns following infection or immune response activation?", "Does the image show altered gene profiles during inflammation, such as activation of cytokine genes?", "Can you identify changes in gene expression that might be associated with aging or cellular senescence?", "Is there variability in gene expression patterns between healthy and diseased tissue regions?", "Does the image indicate changes in gene expression in response to drug exposure or pharmacogenomic effects?", "Can you observe altered gene expression related to genetic disorders or dysregulated pathways?", "Is there evidence of changes in gene expression during cell differentiation, such as the presence of lineage-specific markers?"], "properties": ["Does the image show evidence of a technique capable of detecting transcripts present at very low abundance, such as only a few copies per cell?", "Is there an indication of a method that can distinguish between closely related RNA molecules or isoforms with high specificity?", "Can you identify a process that measures transcript levels across a wide dynamic range, spanning several orders of magnitude?", "Does the depicted workflow suggest the ability to detect expression levels as low as single molecules per sample?", "Is there a representation of a technology that can analyze thousands to millions of RNA molecules simultaneously in a single sample?", "Does the image suggest a method known for producing highly reproducible results under standardized conditions?", "Can you see evidence of an approach that provides resolution down to individual genes or even single exons?", "Is there a process shown that achieves high accuracy in quantifying RNA transcript abundance, validated against reference standards?", "Does the image indicate a technique that requires only a small amount of total RNA input, such as between 1 nanogram and 1 microgram?", "Are there any visual cues suggesting that data output formats include files like FASTQ, BAM, or normalized expression matrices?", "Can you infer from the image whether the typical turnaround time for the depicted process ranges from one day to two weeks?", "Is there evidence of a method with a low error rate, typically below 1% for high-quality results?", "Does the image suggest a process that achieves high sequencing coverage, such as tens to hundreds of millions of reads per sample?", "Can you identify a workflow capable of detecting a broad range of transcripts, potentially numbering from ten thousand to sixty thousand per sample?", "Is there an indication that quantification is performed using techniques such as read counting, signal intensity measurement, or normalization algorithms?"], "relational": ["Does the image show a biological sample such as blood, a tissue biopsy, or a cell culture that could be analyzed for molecular information?", "Is there a structure in the image that contains cellular components like a nucleus, cytoplasm, or ribosomes, which could be assessed for molecular content?", "Can you identify tissue sources such as liver, brain, muscle, or tumor tissue that might be suitable for molecular analysis?", "Does the image contain material where molecules like mRNA, cDNA, or microRNAs could be measured?", "Is there a visible anatomical region such as the cerebral cortex, myocardium, or lymph nodes that could be studied for molecular differences?", "Can you see cell types such as epithelial cells, immune cells, neurons, or stem cells that might be selected for molecular profiling?", "Does the image include structures that are part of the nervous, immune, or endocrine systems, which could be investigated at the molecular level?", "Is there evidence of a tissue biopsy or sample acquisition procedure in the image?", "Can you identify organs, tissues, or isolated cells that could provide material for molecular analysis?", "Does the image allow for a comparison between normal and tumor tissue, or between diseased and healthy organs, based on anatomical or cellular features?"], "contexual_behavior": [], "functions": ["Does the image show a process or technology that measures and compares the expression levels of many genes at once?", "Is there evidence of an analysis that reveals patterns of gene upregulation or downregulation to identify active biological pathways?", "Can you identify a method that uncovers gene expression alterations associated with disease mechanisms or molecular signatures?", "Does the image depict an approach used to guide therapy selection based on individual gene expression patterns for personalized medicine?", "Is there a process shown that assists in monitoring treatment response by detecting changes in gene expression before and after therapy?", "Can you see evidence of a technique that captures shifts in gene activity during physiological or pathological processes to detect cellular changes?", "Does the image include a method used to distinguish unique gene expression signatures among patient groups for disease subtype classification?", "Is there a process depicted that supports biomarker discovery by identifying genes whose expression correlates with disease presence or progression?", "Can you identify an approach that maps expression patterns controlled by regulatory elements to study gene regulation?", "Does the image show a technique that captures temporal or stimulus-induced variations in gene activity?", "Is there evidence of a method used to track gene expression changes during differentiation and growth to understand developmental processes?", "Can you see a process that highlights genes and pathways altered in disease for the purpose of identifying potential drug targets?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure with a density close to that of soft tissue, around 1.03 grams per cubic centimeter?", "Is there a structure that could have a surface area comparable to 1.7 to 2.0 square meters in adults?", "Does the image show a layer with a thickness less than 1 millimeter?"], "relational": ["Can you identify anatomical spaces such as the greater sac or rectouterine pouch defined by a membranous structure?", "Are there organs present that appear to be positioned behind a membranous lining, such as the kidneys or pancreas?", "Does the image show a structure that is part of the digestive system and forms a lining within the abdominal cavity?"], "contexual_behavior": ["Can you identify signs of excess fluid accumulation that might result from injury, peritonitis, malignancy, or liver disease?", "Can you observe features consistent with increased cytokine production, such as those seen in sepsis or systemic inflammation?", "Does the image show features suggestive of adhesion formation following surgical trauma or repeated inflammation?"], "functions": ["Does the image display any signs of adhesions or encapsulated regions that might indicate infection isolation or injury containment?", "Can you identify a scaffold-like feature that could support tissue regeneration or cellular repair?", "Is there a structure that could house immune cells or contribute to cytokine production for pathogen defense?"]}}, "morphologically recognized precursor lesions": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region with cells that have enlarged, darkly staining nuclei and loss of their usual orientation?", "Can you identify an area with a size ranging from a few millimeters up to several centimeters that appears distinct from surrounding tissue?", "Is there a structure with an irregular, flat, papillary, or nodular shape visible in the image?", "Does the image contain a lesion limited to the epithelial layer, with a thickness less than 1 millimeter?", "Can you see a region that appears paler or more basophilic compared to adjacent tissue under microscopy?", "Is there an area where the nuclear-to-cytoplasmic ratio is increased due to larger nuclei?", "Does the image show a region with a higher number of mitotic figures than the surrounding normal tissue?", "Can you identify an area displaying mild to moderate cellular atypia?", "Is there a region where the normal layering of cells is disrupted and tissue organization is lost?", "Does the image show an area with more than two layers of cells, exceeding the normal single or double layer?", "Is there a region where necrosis is absent or only minimally present?", "Can you see nuclei with coarse or irregular chromatin patterns in any part of the image?", "Is there an area where the cytoplasm of the cells is scant and appears either eosinophilic or basophilic?", "Does the image contain a region where abnormal mitotic figures are present at a low to moderate frequency?", "Can you identify an area with varying degrees of dysplasia, ranging from mild to severe, depending on the progression?"], "relational": ["Does the image show an abnormal area originating from epithelial, glandular, or mucosal tissue?", "Is there a lesion present within an organ of the gastrointestinal, respiratory, or reproductive system?", "Can you identify a suspicious region in the colon, cervix, breast, esophagus, or prostate?", "Does the image reveal cells with features of dysplasia, such as abnormal epithelial, basal, or glandular cells?", "Is there a structure that could potentially progress to carcinoma or adenocarcinoma?", "Can you see a lesion interacting with stromal tissue, the basement membrane, or adjacent normal epithelium?", "Does the image display evidence of cellular atypia, architectural distortion, or loss of normal tissue polarity?", "Is there a visible boundary defined by the basement membrane or a clear interface with normal tissue?", "Can you identify a region that is juxtaposed to, or appears to transition from, adjacent normal tissue?"], "contexual_behavior": ["Does the image show a lesion with increased cellular proliferation, possibly in response to growth signals or oncogenic mutations?", "Can you identify an area where differentiation appears impaired, potentially associated with chronic inflammation or persistent cytokines?", "Is there evidence of a lesion that might progress rapidly toward malignancy, perhaps due to genetic or epigenetic alterations?", "Does the image contain a structure with decreased apoptotic activity, possibly influenced by anti-apoptotic signaling or loss of tumor suppressor function?", "Can you observe a lesion that may exhibit an altered response to hormonal changes, such as those caused by receptor dysregulation or signaling pathway abnormalities?", "Is there a region where normal tissue architecture is disrupted, potentially due to loss of cell polarity or adhesion molecules?", "Does the image show a lesion that appears resistant to immune surveillance, possibly through upregulated immune evasion mechanisms?", "Can you see an area with increased metabolic activity, which might be associated with hypoxia and activation of hypoxia-inducible factors or glycolytic pathways?", "Is there evidence of reduced DNA repair capacity in response to genotoxic stress, perhaps due to mutations in DNA repair genes?", "Does the image reveal a lesion with accelerated growth, potentially linked to exposure to carcinogens and acquisition of additional mutations?", "Can you identify a structure with increased vascularization, possibly resulting from overexpression of pro-angiogenic factors?", "Is there a lesion that behaves abnormally during tissue regeneration, perhaps due to altered interactions with regenerative signals?", "Does the image show a region where contact inhibition is lost, possibly under mechanical stress or due to disrupted cell-cell signaling?", "Can you observe a lesion with increased invasive potential, which may be associated with changes in the extracellular matrix and upregulation of proteases or motility factors?", "Is there evidence of a lesion that fails to undergo senescence in aging tissue, potentially due to inactivation of senescence pathways or telomerase activation?"], "functions": ["Does the image show an area with early signs of abnormal cellular changes that could indicate pre-malignancy?", "Can you identify a region that might serve as an early indicator for disease progression toward invasive cancer?", "Is there evidence of atypical cellular proliferation or altered differentiation without signs of tissue invasion?", "Does the image display any disruption of normal tissue organization or changes in the extracellular matrix?", "Can you see a structure that could represent the initial step in the multistep process of cancer development?", "Is there a region exhibiting increased mitotic activity or loss of normal growth control?", "Does the image reveal disorganization of cellular layers or loss of polarity within the tissue?", "Can you identify areas where local immune responses might be modulated, such as regions with increased inflammatory cells or altered cytokine profiles?", "Is there a feature that could serve as a histological marker for early neoplastic transformation?", "Does the image show evidence of interaction with surrounding stromal cells, such as stromal activation or changes in the tumor microenvironment?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show a pale ivory or light yellow area within the temporal bone?", "Is there a structure in the image that appears irregular and wedge-shaped, conforming to the temporal bone?", "Does the image show a bone region with a phosphorus content of about 15-18% by weight?"], "relational": ["Does the image include a region near the internal acoustic meatus?", "Can you identify a structure located at the cranial base of the skull?", "Is there a bony structure that forms the framework protecting the inner ear?"], "contexual_behavior": ["Is there a region where osteitis or bone destruction due to infection may compromise the shielding of the cochlea and vestibular apparatus?", "Does the image suggest abnormal development or incomplete bony partitioning that could expose neurovascular structures due to a congenital anomaly?", "Does the image show any signs of trauma, bony disruption, or displacement that could alter support for cranial nerve passage?"], "functions": ["Does the image show a region that anchors and encases auditory structures involved in sound transmission?", "Is there an area that houses the vestibular system, which is essential for maintaining balance and equilibrium?", "Can you see a structure that shields cranial nerves such as the facial and vestibulocochlear nerves as they pass through the temporal bone?"]}}}
[ { "answer": "close-up view of meaty appearing metastatic lesion in temporal and posterior fossa", "extracted_concepts": [ "metastatic lesion", "posterior fossa" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "meaty appearing metastatic lesion", "posterior fossa", "close-up view", "temporal" ], "question": "does this image show close-up view of meaty appearing metastatic lesion in temporal and posterior fossa?" }, { "answer": "no", "extracted_concepts": [ "temporal", "metastatic lesion", "posterior fossa", "section", "adrenal capsule" ], "question": "does outside adrenal capsule section show close-up view of meaty appearing metastatic lesion in temporal and posterior fossa?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "skull" ], "question": "is bone, skull present?" }, { "answer": "no", "extracted_concepts": [ "atrophy" ], "question": "is atrophy present?" }, { "answer": "metastatic carcinoma", "extracted_concepts": [ "metastatic carcinoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "metastatic carcinoma" ], "question": "is metastatic carcinoma present?" }, { "answer": "no", "extracted_concepts": [ "atheromatous embolus" ], "question": "is atheromatous embolus present?" }, { "answer": "bone, skull", "extracted_concepts": [ "bone", "skull" ], "question": "what is present?" }, { "answer": "metastatic carcinoma", "extracted_concepts": [ "metastatic carcinoma" ], "question": "what is present?" } ]	["temporal", "close-up view", "atheromatous embolus", "bone", "metastatic carcinoma", "meaty appearing metastatic lesion", "metastatic lesion", "skull", "atrophy", "posterior fossa", "section", "adrenal capsule"]	{"temporal": {"yes_questions": {"contexual_properties": ["Does the image show a brain region that appears enlarged, which could be related to a tumor, developmental malformation, or chronic epilepsy?", "Is there evidence of shrinkage or atrophy in a brain area that might suggest neurodegenerative disease, dementia, or a history of seizures?", "Can you identify abnormal imaging signals in a region that could indicate stroke, encephalitis, tumor, or demyelinating disease?", "Is there a visible lesion that might be due to infection, neoplasm, vascular event, or trauma?", "Does the image reveal atrophy in a brain area commonly affected by Alzheimer's disease, frontotemporal dementia, or epilepsy?", "Are there volume changes in a brain region that could be associated with aging, neurodegeneration, or prolonged seizures?", "Is there evidence of edema in a brain area that might result from acute encephalitis, trauma, or ischemic injury?", "Can you see signs of increased metabolic activity in a region that could be related to seizures or tumors?", "Is there decreased metabolic activity in a brain area that might be seen in Alzheimer's disease, chronic epilepsy, or after infarction?", "Does the image show calcifications in a region that could be due to chronic infection, congenital disorder, or tumor?", "Are there alterations in tissue composition in a brain area that might suggest demyelinating disease, neoplasm, or infarction?", "Is there increased vascularity in a region that could indicate a high-grade tumor, arteriovenous malformation, or inflammation?", "Can you identify discoloration in a brain area that might result from hemorrhage, infarction, or chronic gliosis?", "Is there evidence of abnormal cell density in a region that could be associated with cortical dysplasia, tumor, or chronic epilepsy?", "Does the image show demyelination in a brain area, possibly due to multiple sclerosis, progressive multifocal leukoencephalopathy, or acute disseminated encephalomyelitis?", "Are there MRI signal changes in a region that could indicate encephalitis, stroke, tumor, or demyelinating disease?", "Can you see signs of sclerosis in a brain area, which might be related to mesial temporal sclerosis and chronic epilepsy?", "Is there evidence of herniation or edema in a brain region that could be caused by increased intracranial pressure?", "Does the image reveal cystic changes in a brain area that might result from a low-grade tumor, parasitic infection, or infarction?", "Is there hemorrhage in a brain region that could be due to trauma, vascular malformation, or hemorrhagic stroke?"], "properties": ["Is there a structure in the image that measures approximately 7 cm in length and 4 cm in height in adults?", "Can you identify an object that typically weighs between 30 and 40 grams in adults?", "Does the image show a structure with an irregular shape featuring multiple projections and cavities?", "Is there a region that appears off-white to pale yellow in color?", "Can you see an object that might have a density in the range of 1.8 to 2.0 g/cm\u00b3?", "Is there a structure likely composed primarily of hydroxyapatite containing calcium and phosphate?", "Does the image include a region where thickness varies from as thin as 2 mm to over 8 mm?", "Can you identify an object with a width of about 4 to 5 cm?", "Is there a structure with a hard and compact texture, possibly with some spongy areas?", "Does the image show a region that could contain cell types such as osteocytes, osteoblasts, or osteoclasts?", "Is there an object that might have a calcium concentration of 20-25% by weight?", "Can you see a structure with a phosphorus concentration of about 10-12% by weight?", "Does the image include a region where porosity ranges from 5% to 15% depending on location?", "Is there an object with an estimated volume of 15-20 cm\u00b3 in adults?", "Can you identify a structure whose organic matrix contains roughly 20% collagen?", "Is there a region with low marrow content, mainly present in a specific portion such as the mastoid?", "Does the image show a structure with a surface area estimated between 30 and 40 cm\u00b2 in adults?", "Is there an object that might have a water content of about 10-20% by weight?"], "relational": ["Is there a structure located in the lateral region of the skull visible in the image?", "Can you identify a bone that is adjacent to the parietal or zygomatic bones?", "Does the image show a region containing the middle or inner ear?", "Is there evidence of cranial nerves such as the facial or vestibulocochlear nerve passing through a visible area?", "Can you see any muscles like the temporalis or sternocleidomastoid attaching to a bone in the lateral skull?", "Is there a joint such as the temporomandibular joint or squamosal suture present in the image?", "Does the image show arteries like the superficial temporal artery supplying a region of the skull?", "Can you identify veins such as the superficial temporal vein draining a visible area?", "Is there a structure that houses or protects the tympanic cavity?", "Are anatomical landmarks such as the mastoid process, zygomatic process, styloid process, or external acoustic meatus visible in the image?"], "contexual_behavior": ["Is there evidence of a brain region showing increased activity during memory encoding or retrieval?", "Can you identify an area that might exhibit progressive dysfunction in the early or moderate stages of Alzheimer's disease?", "Does the image show a region of the cortex that could be involved in altered processing during auditory hallucinations, as seen in schizophrenia?", "Is there a brain area that might be acutely impaired following traumatic injury, such as contusions or diffuse axonal injury?", "Can you see a structure that would be more active during complex language comprehension or semantic analysis?", "Is there a region that would show decreased activity during deep sleep, particularly in slow-wave or non-REM stages?", "Does the image include an area that could fail to process rapid or complex sounds accurately, as in auditory processing disorders?", "Can you identify a region that might display abnormal electrical discharges during epileptic seizures?", "Is there a brain area that would show reduced activation in aging, especially during memory or auditory tasks?", "Does the image show a region whose function could improve after cognitive rehabilitation in patients recovering from brain injury or stroke?", "Is there a structure that would alter its neural activity during emotional stress?", "Can you see a region that would show increased activity during music perception, especially in areas related to auditory and emotional processing?", "Does the image include a brain area that contributes less to facial recognition in cases of prosopagnosia, particularly due to dysfunction in the fusiform gyrus?", "Is there a region that could be disrupted by hypoxia, especially during periods of reduced oxygen supply?", "Can you identify an area that would show increased metabolic activity during language tasks, particularly in the superior temporal gyrus?"], "functions": ["Does the image show a region that houses structures responsible for hearing and balance?", "Can you identify an area that protects parts of the brain involved in auditory processing?", "Is there a visible structure associated with interpreting sound characteristics such as pitch and volume?", "Does the image contain a region linked to language comprehension, such as the area responsible for interpreting spoken and written language?", "Can you see a part of the brain essential for memory formation, particularly involving medial temporal structures?", "Is there a region that interacts with the limbic system to process emotional stimuli?", "Does the image show an area involved in integrating auditory, visual, and olfactory information?", "Can you identify a region specialized in facial recognition through visual processing?", "Is there a structure that aids in understanding speech by analyzing auditory signals?", "Does the image contain a region that enables recognition of objects by integrating visual and auditory information?", "Can you see an area that supports learning and memory retrieval through hippocampal circuits?"]}, "no_questions": {"contexual_properties": ["Are there calluses visible, possibly resulting from repeated friction or manual labor?", "Are there changes in skin texture, such as thickening or scaling, that could be related to scleroderma or chronic dermatitis?", "Do any areas appear to lack sensation, as might occur in peripheral neuropathy or nerve compression?"], "properties": [], "relational": ["Is there evidence of joints connecting certain structures to the hand or foot, such as metacarpophalangeal or metatarsophalangeal joints?", "Can you see structures that would receive nerve supply from nerves like the median, ulnar, radial, tibial, or peroneal nerves?", "Does the image show structures that are part of both the musculoskeletal and integumentary systems?"], "contexual_behavior": [], "functions": ["Can you identify something that provides opposable surfaces for precision grip or dexterity?", "Is there a structure used for gesturing, forming signs, or nonverbal communication?", "Is there a structure in the image that enables grasping or manipulation of objects?"]}}, "close-up view": {"yes_questions": {"contexual_properties": ["Does the image reveal changes in texture that might suggest inflammation, fibrosis, or abnormal cell growth?", "Is there evidence of discoloration that could indicate bruising, jaundice, cyanosis, or localized bleeding?", "Can you observe swelling that might be due to fluid accumulation, infection, or recent trauma?", "Are there abnormal surface features such as ulceration, nodules, or irregular growths visible?", "Does the image show increased redness that could be associated with inflammation, infection, or an allergic reaction?", "Are there lesions or spots present that resemble petechiae, macules, or papules?", "Can you detect changes in moisture level, such as excessive sweating, dryness, or the presence of exudate?", "Is there visible scaling or flaking that could be related to conditions like psoriasis, eczema, or a fungal infection?", "Do you see changes in the size of any structures that might suggest hypertrophy, atrophy, or tumor formation?", "Is there abnormal pigmentation present, such as areas of depigmentation, dark patches, or post-inflammatory color changes?", "Are there areas of tissue breakdown or ulceration that could be due to infection, pressure, or poor blood supply?", "Can you observe thickened tissue that might indicate lichenification, callus formation, or chronic inflammation?", "Is there loss of normal structure suggestive of necrosis, erosion, or tissue destruction?", "Does the image show increased vascularity that could be due to new blood vessel formation, inflammation, or vascular malformations?", "Are there signs of fluid accumulation or edema that might result from increased vascular permeability, lymphatic blockage, or heart failure?"], "properties": ["Does the image display a region with high magnification, such as between 5x and 40x?", "Is there an area where small structures are shown in fine detail due to high resolution?", "Can you identify a portion of the image that covers only a limited area of the subject?", "Is there a region where only a thin plane is in sharp focus, indicating a shallow depth of field?", "Does the image contain features that appear on a millimeter or micrometer scale?", "Is there a section where the colors appear highly accurate and true to the subject?", "Can you see an area with increased contrast that helps distinguish fine details and boundaries?", "Is there a region of the image that appears especially sharp and free from distortion?", "Does any part of the image exhibit a high pixel density, resulting in crisp and detailed visualization?", "Is there evidence of bright lighting or enhanced illumination on a small area of the subject?"], "relational": ["Does the image provide a perspective where individual cells or capillaries are visible?", "Can you observe anatomical features such as cell layers or microvasculature in the depicted tissue?", "Is there evidence of glandular units or extracellular matrix in the detailed area shown?", "Does the image reveal cellular components like nuclei, mitochondria, or cell membranes?", "Can you see microscopic details while still recognizing the broader anatomical context?", "Are microstructures such as basement membrane, tight junctions, or microvilli apparent in the view?", "Does the image allow you to distinguish between tissue, cellular, and subcellular levels of organization?", "Can you identify connections between cells, such as cell junctions, intercellular bridges, or synapses?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Does the image contain a region located at the lower back part of the cranial cavity?", "Can you identify an area that is situated near the base of the skull and behind the temporal bone?", "Is there a visible space that could be associated with the posterior aspect of the brain?"], "properties": ["Is there a region in the image that measures approximately 5 to 7 centimeters in width and 4 to 6 centimeters in depth in an adult specimen?", "Does the image contain bone that likely includes hydroxyapatite, calcium, and phosphate as its main mineral components?", "Is there an area with a surface area estimated between 40 and 60 square centimeters?"], "relational": ["Is there a visible area related to the sigmoid sinus or jugular vein?", "Is there a region through which cranial nerves such as the trigeminal, facial, or vestibulocochlear nerves pass?", "Can you see tissues or organs adjacent to a cranial region, such as the middle ear, mastoid air cells, pharynx, or cervical spinal cord?"], "contexual_behavior": ["Does the image show a region that could house structures such as the cerebellum or brainstem?", "Is there a visible area that could correspond to the temporal region of the cranial cavity?", "Is there an area visible that could be associated with the lower part of the cranial cavity?"], "functions": ["Does the image include areas or pathways involved in auditory, vestibular, or somatosensory processing?", "Is there a region that supports motor coordination by housing the cerebellum and its neural connections?", "Can you identify an area that provides protection to critical brain regions such as the temporal lobe, cerebellum, or brainstem?"]}}, "atheromatous embolus": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show any structures measuring between 100 micrometers and several millimeters in size?", "Can you identify any objects with an irregular or fragmented shape?", "Is there a structure composed mainly of cholesterol crystals, lipids, calcium, and cellular debris?", "Do you see any areas with a yellowish-white coloration?", "Is there evidence of a structure with a high cholesterol content?", "Can you find an object with substantial lipid content, primarily due to cholesterol and other lipids?", "Are there regions containing microcalcifications or variable amounts of calcium?", "Does the image reveal a structure with a friable and granular texture?", "Is there an object with heterogeneous density, reflecting a mixture of lipids, calcium, and cellular material?", "Can you observe single or multiple similar structures within a vessel?", "Are there cells such as macrophages, foam cells, or smooth muscle cells present within a structure?", "Is there a region with moderate protein content, mainly from cellular debris and extracellular matrix proteins?", "Do you see any structures with relatively low water content compared to normal blood clots?", "Is there a visible accumulation of crystalline material, particularly cholesterol crystals, in significant amounts?", "Can you identify any objects with a thickness ranging from 0.1 to several millimeters?"], "relational": ["Does the image show evidence of obstruction in arteries or arterioles?", "Can you identify any signs of vascular blockage affecting the cerebral or renal circulation?", "Is there a structure that could originate from arterial plaques, such as material from the aorta or carotid arteries?", "Does the image contain features consistent with cholesterol crystals or lipid debris within a blood vessel?", "Can you see any tissue changes in the brain, renal cortex, or peripheral tissues that might result from downstream vascular obstruction?", "Is there evidence of compromised blood flow to the brain, kidneys, or lower limbs?", "Does the image suggest the presence of foam cells or other components associated with arterial embolization?", "Can you identify any vascular territories, such as the cerebral or peripheral arteries, that appear affected by embolic material?", "Is there a visible relationship between atherosclerotic plaque rupture and material found within a vessel?", "Does the image show any anatomical evidence of embolic events impacting the lower extremities?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structure causing vascular obstruction within an artery?", "Is there a visible blockage within a blood vessel that could impede normal blood flow?", "Can you identify a region where arterial blockage might be leading to embolic occlusion?", "Does the image suggest tissue ischemia due to lack of oxygenated blood supply downstream of a vessel?", "Is there an area of decreased perfusion to an organ that could be explained by arterial obstruction?", "Can you see signs of tissue necrosis or infarction that might result from prolonged arterial blockage?", "Is there evidence of an inflammatory response, such as leukocyte accumulation, at the site of a vascular blockage?", "Does the image show microvascular obstruction, such as blocked small arterioles or capillaries, leading to localized hypoxia?", "Can you identify features suggesting organ dysfunction or ischemic damage due to compromised blood supply?", "Is there a region in the brain where a cerebral artery appears occluded, potentially indicating a focal ischemic event?", "Does the image display characteristics of an acute vascular event, such as sudden arterial occlusion and tissue injury?"]}, "no_questions": {"contexual_properties": ["Can you identify calcifications that may have formed during chronic necrosis or after therapy?", "Does the image reveal a mass with variable texture, possibly due to fibrosis, necrosis, or effects of treatment?", "Does the image show a mass with infiltrative borders, indicating invasive properties or tissue degradation?"], "properties": ["Is there evidence of a neoplasm with less than 1% of cells positive for progesterone receptor?", "Does the tumor in the image appear to be of high histological grade, such as grade 3?", "Does the tumor appear larger than 2 cm in size?"], "relational": ["Can you see histological features consistent with invasive ductal carcinoma or medullary carcinoma?", "Does the image show a malignant epithelial tissue within the breast?", "Are there any regions suggestive of lymphatic invasion or involvement of axillary lymph nodes?"], "contexual_behavior": ["Does the image suggest improved immune recognition, such as enhanced T cell infiltration, after checkpoint inhibitor treatment?", "Does the image show increased angiogenic activity, such as enhanced blood vessel formation during tumor progression?", "Is there evidence of increased cell cycle progression, possibly following the loss of tumor suppressors such as p53 or RB?"], "functions": ["Does the image suggest uncontrolled cancer cell proliferation without signs of hormone or HER2-mediated growth regulation?", "Can you distinguish a neoplasm with a distinct molecular profile or unique therapeutic vulnerabilities compared to hormone-dependent subtypes?", "Does the tumor display features linked to greater aggressiveness or a poorer clinical prognosis compared to other subtypes?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Is there evidence of a watery exudate that might indicate an early or acute infection?", "Is there a visible exudate that might be associated with a foul odor, suggesting anaerobic infection or tissue necrosis?", "Do you see signs that a substance might be more acidic, possibly due to intense bacterial metabolism or anaerobic infection?"], "properties": ["Is there a collection of fluid that might have a protein concentration between 3 and 6 g/dL?", "Does the image show a collection that could contain a high concentration of bacteria?", "Does the image contain material that could be rich in neutrophils or macrophages?"], "relational": ["Does the image contain a localized collection within an abscess cavity?", "Can you identify a region that might contain neutrophils or dead macrophages?", "Is there a region that suggests the presence of an infected wound resulting from an immune response to bacterial invasion?"], "contexual_behavior": ["Is there evidence of delayed healing or persistent accumulation that might be seen in malnourished individuals with impaired immunity?", "Does the image show evidence of increased neutrophil response and bacterial lysis, suggesting an acute infection?", "Is there a sign of localized accumulation that could indicate inefficient drainage or a robust immune response?"], "functions": ["Can you identify an accumulation that suggests the recruitment of neutrophils or other immune cells at a site of inflammation?", "Does the image show evidence of a substance involved in collecting and removing dead cells or debris from an area of infection?", "Can you see a localized collection that could be playing a role in isolating infection and facilitating tissue repair?"]}}, "metastatic carcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show abnormal tissue invading connective, muscle, epithelial, or nervous tissue?", "Can you identify lesions affecting organs such as the liver, lungs, bones, or brain?", "Is there evidence of abnormal cells utilizing lymphatic vessels or lymph nodes to reach distant sites?", "Does the image suggest a possible origin from tissues like breast, lung, colon, prostate, or skin?", "Can you see signs of disease spreading through the circulatory or lymphatic systems?", "Is there a structure that appears to facilitate the movement of abnormal cells, such as blood vessels, lymphatic vessels, or basement membrane disruption?", "Are there visible abnormalities in regions commonly targeted by secondary tumors, such as the liver, lungs, bones, brain, or lymph nodes?", "Does the image show abnormal cells interacting with or invading blood vessels or capillaries?", "Is there evidence of cells crossing anatomical barriers like the basement membrane, endothelial barriers, or the blood-brain barrier?", "Can you identify both a primary lesion and a separate secondary lesion, suggesting the spread of malignant cells from one site to another?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal cell clusters invading surrounding tissues?", "Can you identify areas where healthy tissue appears to be replaced or disrupted, potentially impairing organ function?", "Is there visual evidence of tissue structures being breached, such as the basement membrane or extracellular matrix?", "Does the image reveal signs of new blood vessel formation that could be stimulated by pro-angiogenic factors?", "Can you see regions where the local tissue environment appears altered, such as increased stromal cell presence or changes in matrix composition?", "Is there evidence of immune cell infiltration or inflammation, possibly due to cytokine release?", "Does the image display features suggestive of fibroblast activation or increased matrix metalloproteinase activity?", "Are there signs of abnormal cellular proliferation or expansion beyond normal tissue boundaries?", "Can you observe areas that might indicate hypoxia or nutrient competition, such as poorly vascularized or necrotic regions?", "Is there visual indication of organ dysfunction or structural compromise, such as distortion or loss of normal architecture?", "Does the image suggest the presence of cells that may be resisting apoptosis or exhibiting survival advantages?", "Can you identify features that could be associated with altered growth factor signaling or disrupted intercellular communication?", "Is there evidence of metastatic spread, such as abnormal cell clusters present in distant organs or tissues?", "Does the image show signs of cachexia or systemic metabolic effects, such as tissue wasting or loss of normal tissue mass?"]}, "no_questions": {"contexual_properties": ["Can you identify abnormal cranial structures that might result from incomplete cranial division in the prenatal period?", "Does the image show changes in the size of shared organs that could be attributed to developmental constraints from conjoined anatomy?", "Does the image display differences in skull composition, such as variable degrees of fusion or ossification during fetal growth?"], "properties": ["Are the facial features arranged in a mirror-image pattern across the sagittal plane?", "Are there four ears present, with two ears per face?", "Does the image depict two distinct sets of facial features, each on opposite sides of the head?"], "relational": ["Is there a structure in the image where organ systems in the torso appear shared, but cranial features are duplicated?", "Are there duplicated facial bones, such as maxillae and zygomatic bones, present on a single fused cranium?", "Does the image depict a form of conjoined twinning characterized by craniofacial duplication rather than fusion at the thorax or pelvis?"], "contexual_behavior": ["Does the image depict abnormal feeding behavior, possibly due to both mouths attempting to feed at the same time or interference between oral structures?", "Can you identify signs of altered breathing patterns that could result from shared thoracic structures or malformed thoracic organs?", "Can you observe features that might indicate difficulty in regulating body temperature, such as duplicated heads or increased surface area?"], "functions": ["Does the image display abnormal vascular connections or duplications in the head and neck region?", "Can you identify features that might lead to homeostatic instability, such as temperature, fluid, or metabolic imbalance?", "Can you identify evidence of conjoined twinning involving two faces on a single head?"]}}, "meaty appearing metastatic lesion": {"yes_questions": {"contexual_properties": ["Does the image contain a lesion with a solid, flesh-like appearance?", "Is there a structure that could represent a secondary growth from a primary tumor elsewhere in the body?", "Can you identify an abnormal mass that appears different in texture or color compared to surrounding tissues?", "Is there a visible lesion that might suggest the spread of malignant cells to a new location?"], "properties": [], "relational": ["Is there a structure present within parenchyma, muscle, or subcutaneous tissue that appears distinct from the surrounding tissue?", "Can you identify an abnormal area within the lung, liver, skeletal muscle, or lymph nodes?", "Does the image show a lesion adjacent to blood vessels, nerves, or surrounding parenchyma?", "Is there evidence of a secondary tumor that may have originated from a different primary neoplasm?", "Can you see a mass that could involve the circulatory or lymphatic systems?", "Is there a region that might contain malignant epithelial cells, stromal cells, or inflammatory cells?", "Does the lesion appear to be associated with capillaries, arterioles, or venules?", "Can you identify any interaction between the abnormal area and lymphatic vessels, regional lymph nodes, or lymphatic sinuses?", "Is there a mass located specifically within the lung parenchyma, liver parenchyma, or skeletal muscle?", "Does the lesion appear to be supported by fibrous stroma, extracellular matrix, or collagen fibers?"], "contexual_behavior": [], "functions": ["Does the image show a solid, fleshy mass that appears to invade and replace normal tissue structures?", "Is there evidence of a lesion causing disruption or compression of surrounding healthy cells?", "Can you identify an area where normal organ architecture is lost, potentially leading to impaired function?", "Does the image reveal a mass that might be compressing blood vessels or causing abnormal new vessel formation?", "Is there a region that could be associated with local tissue ischemia due to vascular compression?", "Can you see signs of increased cell proliferation or reduced cell death within a mass?", "Is there visual evidence of local inflammation or tissue disruption near a tumor-like structure?", "Does the image contain a mass that appears to support further tumor growth or invasion into adjacent tissues?", "Is there a structure that could be creating an immunosuppressive environment or evading immune detection?", "Can you identify a lesion interacting with or degrading the extracellular matrix, leading to tissue remodeling?", "Is there a mass that appears to be stimulating new blood vessel formation, possibly through angiogenesis?", "Does the image suggest the presence of tumor cells detaching or migrating away from a primary lesion?", "Is there a region that might show increased glucose uptake or altered metabolic activity, such as hypoxic areas within a mass?", "Can you observe changes in the tissue microenvironment, such as inflammation or stromal cell activation, surrounding a lesion?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of activation by membrane receptors like receptor tyrosine kinases or G protein-coupled receptors?", "Can you identify localization near organelles such as endosomes or lysosomes?", "Does the image show a structure associated with the plasma membrane or cytosol?"], "contexual_behavior": [], "functions": ["Is there a structure or process depicted that could be involved in lipid kinase activity or signal transduction?", "Is there evidence of immune cell activation, such as lymphocyte signaling or cytokine response, that could be mediated by a key signaling molecule?", "Does the image display changes in cytoskeletal organization, such as actin polymerization or alterations in cell shape during migration or division?"]}}, "metastatic lesion": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears to be increasing in size, suggesting disease progression or inadequate response to therapy?", "Is there an area that has decreased in size, indicating a possible response to treatment or tumor cell death?", "Can you identify a region that has changed shape, possibly due to invasion into surrounding tissue or effects of therapy?", "Does the image reveal a structure with increased vascularity, which might indicate angiogenesis driven by tumor growth?", "Is there a region with altered density, such as areas that appear necrotic, hemorrhagic, fibrotic, or calcified?", "Can you see evidence of necrosis within a lesion, possibly due to insufficient blood supply or cytotoxic therapy?", "Is there a focus of calcification that could be the result of dystrophic mineralization following necrosis?", "Does the image display a lesion with color changes, such as areas of hemorrhage, necrosis, or pigmentation?", "Is there a region with a different texture, perhaps due to fibrosis, necrosis, or cystic degeneration?", "Can you identify a structure that might have increased metabolic activity, suggesting rapid tumor cell proliferation?", "Is there a lesion with a cystic appearance, possibly resulting from central necrosis or liquefaction?", "Does the image show evidence of hemorrhage within a lesion, such as areas of acute bleeding or vessel rupture?", "Is there a region that appears more cellular, which could indicate active tumor growth or a high-grade malignancy?", "Can you see a structure that has lost its normal integrity, possibly due to extensive necrosis or rapid growth?", "Is there a lesion surrounded by a fibrous capsule, suggesting a chronic process or host tissue reaction?", "Does the image show edema around a lesion, which might result from vascular disruption or inflammation?", "Is there a region with heterogeneous composition, displaying mixed areas of necrosis, hemorrhage, fibrosis, or viable tumor tissue?", "Can you identify a lesion that would likely show increased uptake on a PET scan due to elevated glucose metabolism?", "Is there evidence of a structure becoming more infiltrative, with tumor cells invading adjacent tissues?", "Does the border of a lesion appear less defined or altered, possibly due to invasive growth or therapeutic response?"], "properties": ["Is there a structure in the image that appears irregular or nodular in shape?", "Can you identify an area that ranges in size from a few millimeters to several centimeters?", "Does the image show a mass with a gray-white or tan coloration?", "Is there a region that appears denser than the surrounding normal tissue, possibly with areas of variable density?", "Can you see a lesion that might contain both malignant and inflammatory cells?", "Is there evidence of increased vascularity or new blood vessel formation within any abnormal structure?", "Does any area display features suggestive of high cellular proliferation, such as a high mitotic index?", "Is there a region where the cells seem to have a high nuclear-to-cytoplasmic ratio?", "Can you identify a mass that appears firm or hard, with possible softer areas indicating necrosis?", "Is there a lesion that seems poorly or moderately differentiated compared to surrounding tissue?", "Does any structure show signs of rapid or accelerated growth relative to other lesions?", "Can you see evidence of necrosis, such as areas of tissue breakdown within a mass?", "Is there a region that might express proteins like cytokeratins, vimentin, or HER2, depending on the tumor type?", "Does any lesion appear to have variable or increased lipid content, possibly indicating adipogenic differentiation?", "Is there an area where the water content appears normal or slightly increased, perhaps due to edema?", "Can you identify a mass with occasional calcification, especially if the tumor type is known to be mucinous?", "Is there a region that might harbor genetic alterations such as KRAS, TP53, or EGFR mutations?", "Does any abnormal structure exhibit an acidic microenvironment, possibly reflecting increased glycolysis and hypoxia?"], "relational": ["Does the image show an abnormal area within epithelial, connective, nervous, or muscle tissue?", "Is there a suspicious region affecting organs such as the liver, lungs, brain, or bones?", "Can you identify a structure that might represent the spread of malignant cells from a primary tumor to a distant site?", "Is there evidence of involvement in the skeletal, nervous, respiratory, or digestive systems?", "Does the image display an abnormality adjacent to parenchyma, blood vessels, lymphatic vessels, or connective tissue?", "Can you see a region that could contain malignant tumor cells along with stromal or immune cells?", "Is there a visible pattern suggesting spread through blood vessels or lymphatic channels?", "Does the image show an area located in common secondary sites such as the liver, lungs, brain, bones, or lymph nodes?", "Can you identify any lymphatic structures, such as lymph nodes or lymphatic vessels, associated with an abnormal region?", "Is there a suspicious area near veins, capillaries, arteries, or venules that could indicate dissemination?"], "contexual_behavior": ["Does the image show a structure that could be invading surrounding tissues, possibly due to increased protease activity or features of epithelial-mesenchymal transition?", "Is there evidence of a mass with limited new blood vessel formation, which might suggest inhibition of angiogenic signaling?", "Can you identify a lesion that may be evading immune detection, potentially through expression of immune checkpoint molecules or reduced antigen presentation?", "Does the image contain a region where cell proliferation appears reduced, possibly as a response to chemotherapy?", "Is there a structure that might be resisting programmed cell death, perhaps through upregulation of anti-apoptotic proteins?", "Can you see a lesion that could be adapting to a low-oxygen environment by increasing glycolytic activity?", "Is there evidence of extracellular matrix degradation near a mass, which could indicate increased secretion of matrix metalloproteinases?", "Does the image suggest a lesion that is failing to establish itself in a new organ, possibly due to incompatibility with the local microenvironment?", "Can you observe impaired migration of abnormal cells, potentially due to altered expression of adhesion molecules?", "Is there a mass whose growth rate might be influenced by hormonal signals, suggesting the presence of hormone-sensitive receptors?", "Does the image show a lesion with reduced spread, possibly as a result of targeted therapy inhibiting oncogenic pathways?", "Is there evidence that a mass is altering its behavior in response to changes in the surrounding tissue environment?", "Can you identify a lesion that may be more resistant to radiotherapy, potentially due to enhanced DNA repair or antioxidant activity?", "Is there a structure with reduced recruitment of stromal support cells, possibly due to decreased chemokine signaling?", "Does the image suggest enhanced dissemination of abnormal cells in the context of systemic inflammation and increased cytokine activity?", "Can you see a lesion that appears functionally impaired, possibly due to nutrient deprivation in its microenvironment?", "Is there evidence of increased immune evasion following immunosuppressive treatment, such as enhanced activation of immune inhibitory pathways?", "Does the image show a mass with reduced spread and limited neovascularization, potentially as a result of anti-angiogenic therapy?", "Can you observe features suggesting that a lesion is responding to oxidative stress by modulating its signaling pathways or increasing antioxidant defenses?", "Is there evidence that abnormal cells are surviving in circulation, possibly through resistance to anoikis or interaction with platelets or immune cells?"], "functions": ["Does the image show evidence of a secondary tumor site distant from a possible primary tumor?", "Can you identify a structure that suggests tumor dissemination or secondary growth in a new tissue?", "Is there a region that appears to disrupt normal tissue architecture, indicating possible tissue invasion or functional impairment?", "Does the image reveal any abnormal mass that could be interfering with organ function at its location?", "Can you see features that might indicate the spread of malignant cells through the bloodstream or lymphatic system?", "Is there evidence of local tissue inflammation or remodeling of the extracellular matrix near an abnormal structure?", "Does the image contain a mass that could be modulating the local immune response or evading immune surveillance?", "Can you identify signs of new blood vessel formation, such as angiogenesis, associated with an abnormal growth?", "Is there a region that appears hypoxic or shows signs of rapid proliferation outcompeting normal cells for resources?", "Does the image suggest the presence of heterogeneous cell populations within a tumor, potentially indicating therapy resistance?", "Are there visual cues of aberrant cellular signaling, such as abnormal tissue growth or altered paracrine effects?", "Can you see evidence of systemic effects, such as tissue wasting or features consistent with cachexia, that might be linked to a tumor?", "Is there a structure that could be releasing cytokines or contributing to paraneoplastic syndromes?", "Does the image show any abnormality that might be associated with the metastatic cascade, such as signs of cell migration or colonization in a distant tissue?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a layer that consists of only one or two cell layers in thickness?", "Does the image contain cells that appear polygonal or cuboidal in shape?", "Does the image show a tissue with moderate glycogen content, serving as an energy reserve for trophoblast cells?"], "relational": ["Can you see a layer participating in the development of chorionic villi and contributing to the placenta?", "Is there a region derived from embryonic tissues originating from the trophoblast?", "Can you identify a region containing cell types such as cytotrophoblasts or syncytiotrophoblasts?"], "contexual_behavior": [], "functions": ["Can you identify a layer that restricts harmful substances and pathogens while allowing essential exchanges between mother and fetus?", "Does the image show a region involved in promoting adhesion and invasion during the establishment of the maternal-fetal interface at implantation?", "Can you identify a layer that is responsible for selective transport of essential molecules from the mother to the fetus?"]}}, "skull": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with an oval or rounded shape and a slightly elongated anteroposterior axis?", "Can you identify an object that appears off-white or pale ivory due to mineralized bone tissue?", "Is there a structure present that could measure approximately 22 cm in length, 17 cm in width, and 14 cm in height?", "Does the image contain an object whose thickness varies between 4 and 8 millimeters depending on the region?", "Can you see a structure that might weigh between 1.3 and 1.5 kilograms in adults?", "Is there an object composed primarily of compact and spongy bone, collagen fibers, hydroxyapatite, and water?", "Does the image include a structure made up of 22 bones, with both cranial and facial components?", "Can you identify an object with a moderate porosity, especially in regions containing spongy bone?", "Is there a structure whose surface appears mostly smooth but with some roughened areas for muscle attachment?", "Does the image show an object with a circumference of about 55 to 58 centimeters?", "Can you see a structure that might have a bone density ranging from 1.5 to 2.0 g/cm\u00b3?", "Is there an object whose water content is approximately 10% by weight?", "Does the image contain a structure with a mineral content mainly consisting of hydroxyapatite, accounting for about 65% of its dry weight?", "Can you identify an object with a calcium concentration of about 20\u201325% and a phosphorus concentration of roughly 10\u201312% of its total weight?", "Is there a structure with a collagen content of about 20\u201325% of its organic matrix?", "Does the image show an object with a typical hardness of around 5 on the Mohs scale?", "Can you see a structure whose cranial cavity volume could be approximately 1350 to 1500 milliliters?"], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify any bones such as the frontal, parietal, or temporal bones?", "Is there a region visible that could correspond to the cranium or facial skeleton?", "Does the image display features like the calvaria or cranial base?", "Can you see any joints such as cranial sutures or the temporomandibular joint?", "Is there evidence of cavities like the cranial, nasal, or orbital cavities?", "Does the image include a structure that protects the brain or eyes?", "Can you identify an articulation point with the vertebral column, such as the foramen magnum?", "Is there a visible area where muscles like the temporalis or masseter might attach?", "Can you see any foramina, such as the optic canal or jugular foramen?", "Are there distinguishing features such as multiple cavities or complex articulations present?", "Does the image show a structure involved in protecting the inner ear or nasal passages?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides protection for the brain?", "Can you identify a rigid bony cavity that encapsulates neural tissue?", "Does the image show a framework that supports sensory organs such as the eyes or ears?", "Is there a visible structure forming orbital or nasal cavities?", "Can you see attachment points for muscles involved in chewing?", "Does the image include features like the mandible or maxilla that enable mastication?", "Is there a bony framework shaping the forehead, cheeks, or jaw?", "Can you identify surfaces or ridges for the attachment of facial muscles responsible for expression?", "Does the image show structures forming the oral or nasal cavities, which facilitate speech resonance?", "Is there evidence of air-filled cavities that could contribute to sound resonance?", "Can you see anatomical features that protect the entrances to the respiratory or digestive tracts?", "Is there a structure maintaining a closed cavity that could help regulate intracranial pressure?"]}, "no_questions": {"contexual_properties": ["Is there a lesion present that suggests secondary involvement by a cancer typically arising from the prostate?", "Does the image show evidence of a malignant neoplasm originating from a glandular organ in the male reproductive system that has spread to other tissues?", "Can you identify abnormal tissue growth that may indicate the dissemination of a carcinoma from its primary site in the male pelvis?"], "properties": [], "relational": ["Is there visible involvement of pelvic tissues adjacent to the prostate region?", "Can you see any evidence of disease spread to the liver or lungs?", "Does the image show evidence of disease affecting the male genitourinary system?"], "contexual_behavior": [], "functions": []}}, "atrophy": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears reduced in size, possibly due to prolonged disuse or aging?", "Can you identify tissue that looks thinner or less dense, which might suggest a period of malnutrition or reduced stimulation?", "Is there evidence of decreased organ weight or mass, potentially resulting from cell shrinkage or cell loss?", "Does the image reveal tissue that appears structurally degraded or resorbed, indicating possible thinning?", "Can you see a region where muscle mass seems diminished, perhaps due to immobilization, denervation, or cachexia?", "Is there a visible area where normal cells seem to be replaced by connective or fatty tissue?", "Does the image suggest a reduction in cell number, possibly due to increased apoptosis or necrosis?", "Is there a structure that appears more fragile or depleted, which could be due to loss of supportive matrix and cellular content?", "Can you observe a change in tissue color that might be caused by decreased blood supply or fatty replacement?", "Does the image show decreased tissue density, possibly from loss of cellular or extracellular components?", "Is there evidence of disrupted normal architecture in an organ, suggesting structural changes from tissue loss?", "Can you identify increased fat infiltration in a tissue, where muscle or parenchymal cells may have been replaced by adipocytes?", "Does the tissue texture appear altered, such as being softer or more fibrotic than expected?", "Is there a region where function-related biomarkers might be reduced due to loss of functional tissue mass?", "Does the image display visible shrinkage of a tissue or organ, indicating significant volume loss?"], "properties": ["Does the image show a tissue or organ that appears smaller or shrunken compared to what would be expected for its type?", "Can you identify a structure that looks pale or yellowish and possibly translucent?", "Is there evidence of a region with noticeably reduced thickness or volume?", "Does any tissue in the image appear to have a softer, flaccid, or friable texture?", "Can you see an area where the tissue mass or weight seems diminished by a significant proportion?", "Is there a structure that could have lost up to half of its original size or weight?", "Does the image suggest a gradual reduction in tissue size that might have occurred over weeks or months?", "Can you identify a region where the density of cells appears increased, even though the overall number of cells seems reduced?", "Is there visual evidence of increased connective tissue or fibrosis within a tissue, possibly at the expense of normal cellular elements?", "Does any area appear to have altered composition, such as more collagen or less glycosaminoglycan content?", "Can you see signs that suggest a decrease in protein or water content within a tissue?", "Is there a region where individual cells seem smaller than usual, possibly due to reduced cytoplasmic or organelle content?"], "relational": ["Does the image show a reduction in the size or mass of a tissue that could be muscle, brain, liver, or kidney?", "Can you identify any changes in structures belonging to the musculoskeletal, nervous, or endocrine systems that might indicate a loss of tissue?", "Is there evidence of decreased bulk in skeletal muscle, cerebral cortex, or cardiac muscle?", "Does the image reveal alterations in muscle fibers, neurons, or adipocytes that suggest a degenerative process?", "Can you see a region where skeletal muscle tissue appears diminished in mass or strength?", "Is there a visible reduction in the size of the limbs, brain, or heart?", "Does the image display features such as cell shrinkage, loss of tissue mass, or fewer cellular organelles?", "Are there signs of thinning or weakening in connective tissues like tendons, ligaments, or fascia?", "Can you observe structural changes in organs such as the brain, heart, skeletal muscle, or thymus?", "Is there evidence of altered interaction between tissues and the nervous, circulatory, or immune systems that could be due to tissue degeneration?"], "contexual_behavior": [], "functions": ["Does the image show a tissue or organ with visibly reduced size and diminished function compared to normal?", "Can you identify an area where there is evidence of tissue loss or functional decline?", "Is there a structure that appears less efficient or impaired in its normal function?", "Does the image suggest decreased protein content or increased signs of cellular breakdown, such as catabolism or apoptosis?", "Can you see a region where muscle mass appears reduced, potentially leading to weakness or impaired movement?", "Is there evidence of organ dysfunction or cellular loss in any of the depicted tissues?", "Does any area in the image appear to have lower metabolic activity, such as reduced cellular density or hypometabolism?", "Can you identify features that might indicate altered hormonal regulation, neural input, or increased proteolysis in a tissue?", "Is there a region where the capacity for tissue repair or regeneration seems compromised, such as a reduced pool of viable cells?", "Does the image show an area with decreased nutrient uptake or altered metabolic characteristics?", "Can you see evidence of weakened tissue resilience or impaired recovery from injury or stress in any structure?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there an abnormal structure located within the abdominal cavity, thoracic cavity, or neck region?", "Does the image show a lesion that could be present in the endocrine, digestive, or respiratory system?", "Are there arterioles, capillaries, or venules supplying a suspicious area in the image?"], "contexual_behavior": [], "functions": ["Is there evidence of a pro-tumorigenic inflammatory response, such as the presence of recruited immune cells or cytokine-mediated changes in the tissue?", "Does the image suggest resistance to cell death, for example by showing densely packed cells with little evidence of apoptosis?", "Can you see any indication of new blood vessel formation that might be driven by pro-angiogenic factors?"]}}, "posterior fossa": {"yes_questions": {"contexual_properties": ["Is there evidence of an enlarged space that could suggest Dandy-Walker malformation or an arachnoid cyst?", "Can you identify a region that appears compressed, possibly due to a mass such as a tumor or severe swelling?", "Does the image show abnormal fluid accumulation that might indicate hydrocephalus or a cystic malformation?", "Is there a visibly reduced volume in a region that could result from congenital hypoplasia or prior surgical removal?", "Are there structural abnormalities present that might be due to congenital anomalies, trauma, or neoplastic processes?", "Can you see an abnormal mass that could represent a medulloblastoma or ependymoma?", "Is there any displacement of structures that might be caused by mass effect from a tumor, hemorrhage, or edema?", "Does a region appear crowded, as might be seen in Chiari malformation or with reduced cerebrospinal fluid space?", "Is there any indication of increased pressure, such as swelling or compression, that could be due to a tumor, hemorrhage, or obstructive hydrocephalus?", "Can you observe an altered shape in a region that might result from a congenital malformation or surgical intervention?", "Is there evidence of hemorrhage that could be associated with trauma, vascular malformation, or hypertensive crisis?", "Do you see calcifications that might be linked to a tumor, chronic infection, or congenital disorder?", "Are there cystic changes present that could suggest an arachnoid cyst, cystic tumor, or Dandy-Walker malformation?", "Is there visible edema that could be related to acute infarction, tumor, or infection?", "Can you detect changes in tissue density that might indicate infarct, tumor, or hemorrhage?"], "properties": ["Is there a region in the image that appears concave and roughly triangular in sagittal section?", "Can you identify an area bounded posteriorly by the occipital bone, laterally by the petrous part of the temporal bones, and anteriorly by the dorsum sellae?", "Does the image show a space containing neural tissue, meninges, cerebrospinal fluid, and blood vessels?", "Is there a compartment where the brain tissue appears grayish-white and the surrounding fluid is clear?", "Can you see a structure with an estimated volume between 150 and 200 milliliters?", "Is there a region with a width of about 6 to 7 centimeters, a height of 5 to 6 centimeters, and a depth of 4 to 5 centimeters?", "Does the image include an area where the surrounding bone thickness is approximately 4 to 8 millimeters?", "Can you identify a space with a surface area estimated between 60 and 80 square centimeters?", "Is there a compartment where the cerebrospinal fluid volume is approximately 20 to 30 milliliters?", "Does the image show a region where the density of brain tissue is around 30 to 40 Hounsfield units and the surrounding fluid is near zero on CT imaging?", "Can you see an area where the cerebrospinal fluid pressure would typically be between 7 and 15 mmHg?", "Is there a region likely to contain neurons, glial cells, endothelial cells, and meningeal cells?", "Does the image include a space where the cerebrospinal fluid pH is expected to be between 7.31 and 7.34?"], "relational": ["Does the image show a region located at the base of the skull within the cranial cavity?", "Can you identify an area that is bounded by the occipital bone, temporal bones, and part of the sphenoid bone?", "Is there a space containing major brain structures such as the cerebellum, pons, or medulla oblongata?", "Does the image include a region where the cerebellum occupies most of the space?", "Can you see an area that houses the brainstem, including the pons and medulla?", "Is there evidence of cranial nerves V through XII passing through a particular region?", "Does the image show vascular structures such as the vertebral arteries, basilar artery, or dural venous sinuses in a specific area?", "Can you identify dural folds like the tentorium cerebelli or falx cerebelli within the image?", "Is there a region adjacent to the middle cranial fossa or the foramen magnum?", "Does the image display foramina such as the foramen magnum, jugular foramen, internal acoustic meatus, or hypoglossal canal in a particular area?"], "contexual_behavior": ["Does the image show evidence of impaired cerebrospinal fluid circulation, such as signs of obstructive hydrocephalus or mass effect?", "Is there a visible indication of increased intracranial pressure, such as compression of the brainstem or cerebellum?", "Can you identify features suggesting brainstem dysfunction due to mass effect from a tumor or hemorrhage?", "Does the image contain signs of disrupted coordination or cerebellar disorders, such as ataxia or cerebellitis?", "Is there evidence of trauma, such as skull fracture or epidural hematoma, that could decrease protection of neural structures?", "Can you see signs of compromised blood supply in the region supplied by the posterior circulation, such as findings consistent with a posterior circulation stroke?", "Does the image suggest balance impairment or vestibular dysfunction involving the cerebellum or vestibular nuclei?", "Is there evidence of cerebrospinal fluid outflow obstruction at the fourth ventricle or aqueduct, indicating impaired pressure buffering?", "Can you identify a mass lesion that may be compressing cranial nerve nuclei or roots?", "Does the image show features of respiratory dysfunction related to brainstem compression from a mass lesion or edema?", "Are there findings consistent with a congenital malformation, such as Dandy-Walker malformation, leading to impaired cerebrospinal fluid drainage?", "Is there evidence of cerebellar tonsil herniation through the foramen magnum, as seen in Chiari malformation?", "Can you see signs of infection, inflammation, or abscess formation that might alter neural connectivity in this region?", "Does the image reveal cerebellar atrophy with associated impairment of motor coordination?", "Is there evidence of acute hemorrhage affecting the brainstem or surrounding structures, potentially leading to autonomic dysfunction?"], "functions": ["Does the image show a region that houses and protects both the cerebellum and the brainstem?", "Is there an area providing structural support and space for the brainstem and its neural pathways?", "Can you identify a region that enables movement coordination by containing the cerebellum?", "Does the image include a space involved in balance and posture through processing vestibular and proprioceptive information?", "Is there a region that contains multiple cranial nerve nuclei responsible for sensory and motor functions of the head and neck?", "Can you see an area that allows communication between the brain and spinal cord by accommodating major ascending and descending neural tracts?", "Is there a structure involved in regulating vital autonomic functions such as respiration and cardiovascular control?", "Does the image show a region participating in sensory and motor signal integration through the inclusion of the cerebellum and brainstem nuclei?", "Can you identify an area that maintains cerebrospinal fluid flow by containing the fourth ventricle and related cisterns?", "Is there a region contributing to reflex control by housing neural circuits involved in cranial and spinal reflexes?"]}, "no_questions": {"contexual_properties": ["Can you see a region that appears shrunken, possibly from tissue loss or scarring?", "Is there a region that appears pale, possibly due to poor circulation or anemia?", "Is there an area that seems enlarged, which could be due to edema, inflammation, or keloid formation?"], "properties": ["Can you identify a structure composed of cell types such as keratinocytes, fibroblasts, adipocytes, melanocytes, and endothelial cells?", "Is there a structure with moderate blood supply, possibly from branches of the posterior auricular or superficial temporal arteries?", "Does the image include tissue composed of skin, subcutaneous fat, and connective tissue, but with little or no cartilage?"], "relational": ["Does the image show a soft, non-cartilaginous structure at the lower end of the external ear?", "Does the image show a structure that is part of the external ear?", "Can you identify a fleshy region forming the lower portion of the external ear?"], "contexual_behavior": ["Is there a structure that could have a reduced vascular response in the presence of circulatory disorders?", "Is there an area that may be more susceptible to infection after trauma because of disrupted skin barriers?", "Can you identify a region that might display decreased elasticity as a result of aging?"], "functions": ["Can you identify a part of the ear that might cushion and absorb minor impacts to protect the external ear?", "Is there a region that could serve as a site for ornamentation on the external ear?", "Is there a visible area that could detect touch or pressure through cutaneous receptors?"]}}, "section": {"yes_questions": {"contexual_properties": ["Does the image show a tissue sample that appears thicker, possibly due to microtome settings or incomplete embedding?", "Is there a sample that looks thinner, which could result from lower microtome thickness or overprocessing?", "Can you identify a tissue area where the color varies, suggesting different stains or changes in tissue composition?", "Does the sample display regions with increased cellularity, as might be seen in hyperplasia, neoplasia, or inflammation?", "Is there an area with decreased cellularity, which could indicate atrophy, necrosis, or degeneration?", "Can you observe any abnormal staining patterns that might result from altered staining protocols or pathological changes?", "Is there evidence of fragmentation in the tissue, possibly due to brittleness, poor fixation, or excessive thinness?", "Does the sample show increased fibrous tissue, as might occur in chronic inflammation or tissue repair?", "Can you see signs of fluid accumulation, such as edema, within the tissue?", "Is there visible deposition of substances like amyloid, hemosiderin, or lipids, suggesting diseases such as amyloidosis or lipidosis?", "Does the sample contain areas of necrosis, possibly due to cell death from injury, ischemia, or toxins?", "Is there a region that appears more transparent, which could be due to thinness, poor staining, or increased extracellular matrix?", "Can you identify a part of the sample that looks opaque, potentially from increased thickness, heavy staining, or dense fibrotic material?", "Does the tissue architecture appear altered, as might be seen in neoplasia, inflammation, or remodeling?", "Is there evidence of increased immune cell infiltration, suggesting inflammation from infection or autoimmune disease?", "Can you observe any loss of structural integrity, which could result from poor fixation, overprocessing, or necrosis?", "Are there areas showing calcification, possibly indicating dystrophic or metastatic calcification?", "Does the sample appear more eosinophilic, which might reflect increased protein content or cell injury?", "Is there a region that appears more basophilic, suggesting increased nucleic acid content or ribosomal activity?", "Can you see abnormal cell morphology, as might occur in dysplasia, malignancy, or viral infection?"], "properties": ["Is there an object in the image that measures between 1 and 5 centimeters in length?", "Can you identify a structure whose width appears to be within the range of 0.5 to 2 centimeters?", "Does the image show a thin object that could be 3 to 10 micrometers thick, as used in histological analysis?", "Is there a rectangular or oval-shaped area present, reflecting a typical cutting method?", "Can you see a region whose area might fall between 0.5 and 10 square centimeters?", "Is there an object whose estimated volume could be between 1 and 100 cubic millimeters, based on its area and thickness?", "Does the image contain a structure that appears pink, purple, or blue, possibly due to staining under light microscopy?", "Can you identify an object that might have a density close to 1.0 to 1.1 grams per cubic centimeter, as expected for biological tissue?", "Is there a region that could be composed of cellular and extracellular components such as proteins, lipids, carbohydrates, and water?", "Does the surface of any structure appear smooth or display microstructural features typical of prepared tissue samples?", "Can you see an object that might have a refractive index in the range of 1.35 to 1.55, as seen in tissue sections?", "Is there evidence of a structure with high water content, possibly comprising 60% to 80% of its mass?", "Can you identify a region that could contain 10% to 20% protein by mass, as is typical for tissue samples?", "Does the image show an area that might have a lipid content between 2% and 30%, depending on tissue type?", "Is there a structure that could contain 1% to 5% carbohydrate by mass?", "Can you observe differences in staining intensity, ranging from weak to strong, across any regions in the image?", "Is there an object that appears to be maintained at room temperature, approximately 20 to 25 degrees Celsius, during analysis?", "Can you identify a region that might have a pH between 6.8 and 7.4, as expected after typical tissue processing?"], "relational": ["Does the image display a specific slice or subdivision of an anatomical structure?", "Can you identify a portion that serves as a component of a larger organ or tissue?", "Is there a defined area where smaller parts such as cells, fibers, or microstructures are visible?", "Does the image show a region that maintains spatial or functional relationships with the entire structure?", "Can you see a portion containing different tissue types, such as epithelial, connective, muscle, or nervous tissue?", "Is there a visible boundary or landmark that could represent a plane of dissection or a natural demarcation?", "Are there adjacent regions or features that could be neighboring subdivisions or connective tissue within the same organ?", "Does the image include a subdivision that might be used in anatomical nomenclature, histology, or surgical classification?", "Can you identify an area that shares borders and appears functionally continuous with neighboring regions?", "Is there evidence that the displayed portion was created using a specific anatomical plane, such as sagittal, coronal, or transverse?"], "contexual_behavior": ["Is there evidence of localized injury in any tissue area, such as disrupted cellular integrity or altered architecture?", "Can you identify a region where metabolic activity might be impaired due to reduced blood supply or signs of hypoxia?", "Does the image show an area with increased cell proliferation or tissue repair, suggesting regenerative activity after damage?", "Is there a muscle region that appears to have reduced contractile function, possibly indicating fatigue or energy depletion?", "Can you see a brain area that might be experiencing abnormal signaling, as could occur during a seizure?", "Is there a section of the intestine that shows signs of inflammation, such as compromised mucosal integrity or reduced absorption?", "Does the lung tissue display features like filled alveolar spaces, which could indicate impaired gas exchange due to infection?", "Is there a heart region with evidence of cell death or scar tissue, suggesting reduced pumping efficiency after infarction?", "Can you identify a kidney area that may have decreased filtration, possibly due to acute injury to glomerular or tubular cells?", "Is there a liver region that appears to be increasing enzyme production, potentially in response to toxins?", "Does any skin area show loss of barrier function, such as disruption of the epidermal layer after trauma?", "Is there a bone region with signs of increased remodeling activity, as might be seen during fracture healing?", "Can you see a glandular tissue area where secretion appears altered, possibly due to hormonal regulation?", "Is there a spinal cord region that might have lost signal transmission, such as after compression or disruption of axonal pathways?", "Does the pancreas show any area with decreased insulin secretion, which could be associated with beta cell dysfunction in diabetes?"], "functions": ["Does the image show a thin slice or subdivision of tissue prepared for analysis?", "Can you identify a sample that allows detailed observation of cellular and structural organization within the tissue?", "Is there a visible area that reveals spatial relationships among cells and extracellular components?", "Does the image contain a sample suitable for microscopic examination of tissue morphology?", "Can you see a region that could be used for histopathological evaluation or disease identification?", "Is there evidence of cellular abnormalities or pathological changes within the tissue sample?", "Does the image allow for the assessment of cell interactions, proliferation, or differentiation within a defined tissue context?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image contain a mass composed of smooth muscle cells or fibroblasts?", "Can you observe any displacement or compression of the bladder, rectum, or uterine cavity by a mass?", "Is there a lesion present within the submucosal, intramural, or subserosal layers of the uterus?"], "contexual_behavior": ["Does the image show a lesion that could increase inflammatory signaling and local cytokine release during tissue injury or degeneration?", "Is there a structure present that could impair uterine contractility during menstruation by interfering with myometrial function?", "Can you identify a lesion that may alter its vascularization or show increased angiogenesis during pregnancy?"], "functions": ["Can you identify a lesion interacting with adjacent uterine tissues by compressing or displacing the myometrium or endometrium?", "Does the image show a mass that might affect the vascular supply of the uterus, such as by compressing blood vessels or promoting abnormal angiogenesis?", "Is there a mass present that could alter the uterus's responsiveness to estrogen or progesterone?"]}}, "adrenal capsule": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears thickened, which could suggest chronic inflammation, fibrosis, or the presence of a tumor?", "Can you identify a region that seems thinner than usual, potentially indicating atrophy or the effects of prolonged corticosteroid therapy?", "Does the image show evidence of calcification in a capsule-like structure, possibly related to old hemorrhage, tuberculosis, or metastatic disease?", "Is there a visible change in color of a capsule that might be due to hemorrhage, necrosis, or pigment deposition?", "Can you see fibrotic changes in a capsule, which could result from chronic injury, autoimmune adrenalitis, or long-standing inflammation?", "Is there a capsule displaying nodular formations, suggesting nodular hyperplasia or a neoplastic process?", "Does any capsule-like area appear disrupted or lacking integrity, which could be due to trauma, infarction, or severe infection?", "Is there swelling or edema present in a capsule, possibly indicating acute inflammation or infection?", "Can you observe shrinkage of a capsule, which might be associated with chronic atrophy or prolonged corticosteroid exposure?", "Is there abnormal tissue deposition within a capsule, such as might be seen in amyloidosis, metastatic infiltration, or granulomatous disease?", "Does the capsule appear edematous, which could be a sign of acute inflammation, allergic reaction, or vascular compromise?", "Is there hardening of a capsule-like structure, potentially due to fibrosis, calcification, or chronic granulomatous disease?", "Can you identify areas where a capsule appears softened, possibly resulting from acute necrosis, liquefactive changes, or enzymatic digestion?", "Is there increased cellularity within a capsule, which could indicate inflammatory infiltrates, neoplastic invasion, or hyperplasia?", "Does the capsule show irregular texture, scarring, or signs of tumor infiltration?", "Is there evidence of hemorrhage within a capsule, potentially following trauma, coagulopathy, or adrenal vein thrombosis?", "Can you see any disruption of a capsule, possibly caused by direct injury, surgical intervention, or invasive tumors?", "Is there fat accumulation within a capsule, which might be related to aging, obesity, or a lipomatous tumor?", "Does the capsule show inflammatory changes that could be due to autoimmune adrenalitis, infection, or systemic inflammatory diseases?", "Is there a visible change in the composition of a capsule, such as fibrosis, calcification, or infiltration by abnormal cells?"], "properties": ["Is there a thin, fibrous structure enveloping a gland with a crescent or triangular shape?", "Can you identify a whitish or pale layer that conforms to the outer contour of a gland?", "Does the image show a firm, fibrous texture surrounding an organ?", "Is there a region with high density and compact connective tissue visible?", "Can you see a structure with high collagen content and low elastic fiber content?", "Is there a layer composed mainly of dense connective tissue rich in collagen fibers?", "Does the outermost part of the gland appear to have sparse fibroblasts and occasional smooth muscle cells?", "Can you identify a structure whose thickness appears to be very thin, possibly between 50 and 200 micrometers?", "Is there a region whose surface area matches that of the gland, typically between 4 and 6 square centimeters in adults?", "Does the image show a layer with low cellularity, primarily containing fibroblasts?", "Is there an area where the protein content is predominantly structural, such as collagen?", "Can you see a structure with moderate water content, consistent with connective tissue?", "Is there a visible component whose weight would be a small fraction of the gland, likely less than 0.1 grams?"], "relational": ["Does the image show a structure that is part of the endocrine system?", "Can you identify an outer boundary that surrounds the adrenal gland?", "Is there a visible layer that forms the outermost part of the adrenal cortex?", "Does the image contain a region composed primarily of dense connective tissue?", "Can you see a structure adjacent to both the adrenal cortex and periadrenal fat?", "Is there a layer located in the suprarenal region of the abdomen?", "Does the image show a structure that receives blood supply from branches of the superior, middle, and inferior suprarenal arteries?", "Can you identify an area containing collagen fibers and fibroblasts?", "Is there a structure positioned near the kidney and diaphragm?", "Does the image reveal a boundary above the zona glomerulosa of the adrenal cortex?"], "contexual_behavior": ["Does the image show a structure whose extracellular matrix or cellular integrity appears disrupted, as might occur during inflammation?", "Is there evidence of impaired structural support, such as fibrosis or degradation, that could result from immune cell infiltration in autoimmune disease?", "Can you identify a region where altered permeability or changes in cellular junctions might suggest prolonged exposure to stress hormones?", "Does the image reveal compromised barrier function or loss of structural proteins that could be due to infection or the effect of inflammatory cytokines?", "Is there visual indication of thinning, reduced collagen content, or decreased cellular renewal that might be associated with aging?", "Can you see signs of structural failure or invasion that would allow expansion of an adjacent tumor beyond its usual boundaries?", "Is there evidence of increased susceptibility to damage, such as tears or weakness, that could result from trauma or pre-existing structural compromise?", "Does the image suggest developmental defects or impaired composition that might be seen in congenital adrenal disorders affecting protective function?", "Is there any indication of rupture, distension, or vascular injury that could be consistent with acute hemorrhage and increased intracapsular pressure?", "Can you observe changes in compartmentalization or barrier properties that might alter hormone diffusion in disease states?"], "functions": ["Does the image show a structure that serves as a protective outer layer for an endocrine gland?", "Is there a visible feature that provides physical support and separation from surrounding tissues for the adrenal gland?", "Can you identify a barrier that shields an adrenal structure from mechanical injury or infection?", "Does the image contain an enclosing layer that maintains the integrity of the adrenal gland's internal structures?", "Is there evidence of a selective barrier that could regulate the passage of molecules or cells into an adrenal region?", "Can you see a structure that helps preserve the specialized environment of the adrenal cortex by limiting external influences?", "Is there a layer that separates the adrenal cortex from adjacent tissues, supporting compartmentalization within the gland?", "Does the image show a feature that might participate in tissue repair or modulate inflammation in response to injury or stress around the adrenal gland?"]}, "no_questions": {"contexual_properties": ["Are there areas with decreased signal that might correspond to disuse atrophy, denervation, or cachexia?", "Can you observe changes in solubility or aggregation patterns in response to altered ionic strength or pH in the tissue?", "Does the image show fragmented cytoskeletal structures in areas of apoptosis or necrosis?"], "properties": ["Is there a structure that forms globular monomers capable of polymerizing into filamentous assemblies?", "Does the image suggest the presence of a protein with a cellular half-life of about 1 to 2 days?", "Is there a protein present that is highly soluble in its monomeric form in aqueous solutions with appropriate ionic strength?"], "relational": ["Does the image display interactions between cellular structures and the extracellular matrix, basement membrane, or integrins?", "Does the image contain anatomical features such as arterial walls, bronchioles, or the intestinal muscularis?", "Can you identify regions within blood vessels that correspond to the tunica media or vascular smooth muscle layer?"], "contexual_behavior": ["Are there vascular regions where smooth muscle relaxation and reduced constriction might be present following nitric oxide exposure?", "Do any tissues appear aged or senescent, potentially indicating reduced regenerative capacity and decreased contractile protein expression?", "Do uterine tissues in the image show adaptations for increased contractility and remodeling, consistent with pregnancy and preparation for parturition?"], "functions": ["Is there evidence of wound contraction or tissue repair processes occurring in the tissue?", "Does the image show evidence of structures involved in muscle contraction or cytoskeletal support?", "Are there indications of cell movement or migration, possibly due to cytoskeletal rearrangement?"]}}}
[ { "answer": "hemisection of nose", "extracted_concepts": [ "hemisection of nose", "patency", "patent", "left side", "right side" ], "question": "what left side showing patency right side was not patent?" }, { "answer": "side showing patency right side was not patent", "extracted_concepts": [ "side showing patency", "hemisection of nose left", "not patent", "right side" ], "question": "what is hemisection of nose left?" }, { "answer": "yes", "extracted_concepts": [ "hemisection of nose", "not patent", "patency", "left side", "right side" ], "question": "is hemisection of nose left side showing patency right side was not patent?" }, { "answer": "no", "extracted_concepts": [ "patency", "patent", "narrowing of foramen magnum", "odontoid process subluxation" ], "question": "is odontoid process subluxation with narrowing of foramen magnum left side showing patency right side was not patent?" }, { "answer": "hemisection of nose left side showing patency right side was not patent", "extracted_concepts": [ "hemisection of nose", "not patent", "patency", "left side", "right side" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "hemisection of nose", "left side showing patency", "right side was not patent" ], "question": "does this image show hemisection of nose left side showing patency right side was not patent?" }, { "answer": "no", "extracted_concepts": [ "hemisection of nose", "not patent", "nose left side", "patency", "left side", "lesion", "right side" ], "question": "does lesion show hemisection of nose left side showing patency right side was not patent?" }, { "answer": "side showing patency right side", "extracted_concepts": [ "patent", "side showing patency", "patency", "right side" ], "question": "what was not patent?" }, { "answer": "not patent", "extracted_concepts": [ "not patent", "patency", "right side" ], "question": "what was side showing patency right side?" }, { "answer": "yes", "extracted_concepts": [ "patency", "right side" ], "question": "was side showing patency right side not patent?" }, { "answer": "no", "extracted_concepts": [ "not patent", "leiomyoma" ], "question": "was leiomyoma not patent?" }, { "answer": "choanal patency", "extracted_concepts": [ "choanal patency" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "choanal patency" ], "question": "is choanal patency present?" }, { "answer": "no", "extracted_concepts": [ "eye" ], "question": "is eye present?" }, { "answer": "side showing patency right side", "extracted_concepts": [ "not patent", "side", "patency", "right side" ], "question": "what was not patent?" }, { "answer": "not patent", "extracted_concepts": [ "not patent", "patency", "right side" ], "question": "what was side showing patency right side?" }, { "answer": "hemisection of nose", "extracted_concepts": [ "right side was not patent?", "hemisection of nose", "left side showing patency" ], "question": "what left side showing patency right side was not patent?" }, { "answer": "choanal patency", "extracted_concepts": [ "choanal patency" ], "question": "what is present?" }, { "answer": "right", "extracted_concepts": [ "hemisection of nose left side", "not patent", "patency side" ], "question": "how is hemisection of nose left side showing patency side was not patent?" } ]	["hemisection of nose", "right side was not patent", "lesion", "odontoid process subluxation", "eye", "side showing patency", "patent", "leiomyoma", "narrowing of foramen magnum", "side", "nose left side", "right side was not patent?", "hemisection of nose left", "patency side", "left side", "left side showing patency", "not patent", "choanal patency", "hemisection of nose left side", "patency", "right side"]	{"hemisection of nose": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a sagittal section with a curved, triangular profile measuring approximately 2\u20133 cm in width and 3\u20134 cm in height?", "Can you identify a structure that appears to be about half the size of a typical nose?", "Is there an object present that could weigh between 10 and 20 grams based on its size and tissue composition?", "Does the image contain a section displaying pink to reddish coloration due to high vascularization?", "Can you see tissues such as cartilage, bone, mucosa, skin, or connective tissue within a single section?", "Is there evidence of cell types like epithelial cells, chondrocytes, osteocytes, fibroblasts, or endothelial cells in the depicted structure?", "Does the mucosal lining of the section appear to be between 1 and 4 mm thick?", "Can you identify cartilage structures such as septal cartilage, lateral nasal cartilage, or alar cartilage within the section?", "Is there bone present that could correspond to the nasal bone, maxilla, ethmoid bone, or vomer?", "Does the structure exhibit high vascular density, with numerous capillaries or venous plexuses visible?", "Is there an area lined by pseudostratified ciliated columnar epithelium or squamous epithelium?", "Can you infer that the water content of the tissue is approximately 60\u201370% by weight?", "Does the surface area of the section appear to be within the range of 10\u201315 cm\u00b2?", "Is the density of the tissue similar to that of soft tissue, around 1.05\u20131.10 g/cm\u00b3?", "Can you identify a mucosal region that would likely have a slightly acidic pH, around 5.5\u20136.5?"], "relational": ["Does the image show a structure where the nasal septum is visibly divided along the midline?", "Can you identify an anatomical view that separates the left and right halves of both the external and internal nose?", "Is there a region in the image where the nasal cavity and lateral nasal wall are exposed?", "Does the image display tissues such as mucosa, cartilage, bone, and skin within the same section?", "Are bones like the nasal bone, maxilla, or ethmoid bone visible in the exposed area?", "Can you see structures such as the nasal conchae or meatuses within a single nasal cavity?", "Is there evidence of cartilaginous elements such as septal cartilage, lateral nasal cartilage, or alar cartilage being sectioned?", "Does the image reveal the nasal septum in a way that suggests a midline division?", "Are adjacent facial structures like the upper lip, maxillary sinus, or orbit visible in continuity with the exposed nasal area?", "Can you identify a connection between the exposed nasal region and the upper respiratory tract, specifically the nasopharynx?", "Are vascular structures such as branches of the sphenopalatine artery, facial artery, or anterior ethmoidal artery visible in the sectioned area?"], "contexual_behavior": [], "functions": ["Does the image show a surgical alteration that provides access to internal nasal or paranasal structures?", "Is there evidence of a procedure that could disrupt the continuity of the nasal passages, potentially causing airflow obstruction or turbulence?", "Can you identify a modification that would allow for enhanced visualization or instrumentation of deep nasal regions?", "Does the image suggest a change that might impair the sense of smell by affecting the olfactory region or its airflow?", "Is there visible disruption of the mucosal lining that could compromise mucociliary clearance or increase infection risk?", "Can you see anatomical changes that might make nasal breathing less efficient due to increased airway resistance?", "Is there an alteration that could affect normal sinus drainage pathways, possibly increasing the risk of sinusitis?", "Does the image show a loss of mucosal surface or barriers that would reduce the nasal cavity's filtration and humidification functions?"]}, "no_questions": {"contexual_properties": ["Is there evidence of narrowing at the craniovertebral junction due to displacement of the first cervical vertebra?", "Is there a visible change in the shape of the foramen magnum that could be attributed to abnormal alignment of the first cervical vertebra?", "Can you see any obstruction or reduction in the patency of the foramen magnum opening that may be caused by severe displacement of the atlas?"], "properties": ["Does the joint space between the top vertebra and the occipital bone appear narrowed to about 2 millimeters?", "Can you identify a vertebra whose alignment angle is 25 degrees anterior to the normal axis?", "Does the image show a structure at the base of the skull with a markedly reduced opening, consistent with severe narrowing?"], "relational": ["Does the image show any abnormality in the region where the medulla oblongata transitions into the spinal canal?", "Is there a visible impact on the passage of vertebral arteries or the accessory nerve through the large opening at the base of the skull?", "Can you identify the relationship between the first cervical vertebra and the axis vertebra in the image?"], "contexual_behavior": ["Does the image show any narrowing at the large opening at the base of the skull?", "Is there evidence of reduced space where the brainstem transitions into the spinal cord?", "Does the image reveal any abnormal positioning of the atlas vertebra that could compromise the opening at the skull base?"], "functions": ["Can you identify any anatomical changes that could result in symptoms like dysphagia or cardiovascular instability?", "Does the image suggest any compromise to the protected passage for neural pathways at the base of the skull?", "Is there a misalignment of the first cervical vertebra that could directly reduce the space at the craniovertebral junction?"]}}, "right side was not patent": {"yes_questions": {"contexual_properties": ["Does the image show narrowing on one side that could be due to stenosis or chronic inflammation?", "Is there evidence of reduced blood flow on one side, suggesting vascular occlusion or thrombosis?", "Can you observe structural changes on one side that might result from injury, fibrosis, or a congenital anomaly?", "Does the image reveal an obstruction on one side, possibly caused by a clot, plaque, or external compression?", "Is there increased pressure or swelling on one side that could indicate hypertension, obstruction, or heart failure?", "Can you see signs of edema, inflammation, or lymphatic blockage affecting one side?", "Is there abnormal tissue buildup on one side, such as might be seen in atherosclerosis or tumor growth?", "Does one side appear less flexible or more rigid, potentially due to fibrosis, calcification, or chronic inflammation?", "Can you detect thickening on one side that could be related to hypertrophy, chronic inflammation, or scarring?", "Is there discoloration on one side that might result from hemorrhage, ischemia, or infection?", "Does the image show decreased lumen size on one side, possibly due to stenosis, plaque, or chronic inflammation?", "Are there abnormal deposits visible on one side, such as those seen in amyloidosis, calcification, or lipid accumulation?", "Can you observe changes in tissue composition on one side, like fibrosis, fatty infiltration, or necrosis?", "Does one side appear more rigid or stiff, which could be caused by calcification, fibrosis, or chronic scarring?", "Is there evidence of atrophy on one side, possibly due to chronic ischemia, disuse, or neurogenic injury?"], "properties": ["Does the image show a structure on the right side that appears collapsed or occluded?", "Can you identify an area on the right side with a narrowed or absent lumen?", "Is there evidence of increased wall thickness or edema on the right side?", "Does the right side display features of obstruction, such as being filled with debris or thrombus?", "Can you see a region on the right side that appears pale, whitish, or otherwise discolored?", "Is there a firm or rigid area on the right side suggestive of fibrosis or chronic obstruction?", "Does the right side show increased density or fibrous content on imaging?", "Is there a reduction in the size of the right-sided structure compared to normal?", "Can you observe signs of high resistance to flow on the right side, such as near-total occlusion?", "Does the right side contain material that could be fibrous tissue, thrombus, or other obstructive debris?"], "relational": ["Does the image show any evidence of an obstruction or lack of openness in vessels or ducts located on the right half of the body?", "Can you identify any right-sided cardiovascular or respiratory structures, such as the right heart chambers or right bronchus, that appear non-patent?", "Is there a visible interruption or blockage in the right pulmonary artery, right hepatic duct, or right ureter?", "Does the image suggest impaired function or abnormal appearance in organs supplied by right-sided pathways, such as the right lung or right lobe of the liver?", "Are there any differences in the appearance of paired structures, such as the right and left lungs or kidneys, that might indicate a lack of patency on the right?", "Can you see any signs of abnormality in the right thoracic or abdominal cavity that could be related to non-patent right-sided vessels or ducts?", "Is there any visual evidence that the right bronchus or right lymphatic duct is not open or is obstructed?", "Does the image show any changes in the mediastinum, right ribs, or diaphragm that could be secondary to a non-patent right-sided structure?", "Are there any indications that the right side's anatomical connections, such as the inferior vena cava or right phrenic nerve, are affected by a lack of patency?", "Can you observe any consequences of impaired flow or drainage in right-sided organs or tissues, such as congestion or swelling in the right lung or liver?"], "contexual_behavior": ["Does the image show evidence of obstruction or blockage affecting the right side?", "Can you identify signs of decreased blood flow on the right side due to a possible occlusion?", "Is there visual indication that the right side is failing to support normal circulation?", "Does the image suggest reduced oxygen delivery on the right side as a result of impaired flow?", "Can you observe any accumulation of fluid on the right side that might indicate impaired drainage?", "Is there evidence of reduced metabolic exchange on the right side, possibly due to limited movement of blood or lymph?", "Does the image show signs that waste removal is decreased on the right side because of an obstructed outflow pathway?", "Can you detect disruption of normal pressure gradients on the right side, suggesting impaired hemodynamics?", "Is there any indication that immune cell trafficking is altered on the right side due to blocked vascular or lymphatic routes?", "Does the image reveal decreased tissue perfusion on the right side, possibly caused by impaired delivery of blood or fluids?"], "functions": ["Does the image show evidence of an obstruction or closure on the right side of an anatomical structure?", "Is there a visual indication of impaired flow or stasis on the right side?", "Can you identify signs of disrupted transport of fluids, gases, or cells through a pathway on the right?", "Does the image suggest reduced blood flow or circulatory impairment affecting tissues downstream of the right side?", "Is there any indication of congestion or ischemia in tissues supplied by the right side?", "Can you observe features that might indicate compromised organ function due to limited perfusion or drainage on the right?", "Is there evidence of compensatory collateral formation or increased pressure in alternative pathways near the right side?", "Does the image show signs of decreased tissue oxygenation, such as hypoxia, in areas associated with the right side?", "Can you see accumulation or backflow of substances that would normally pass through the right side?", "Is there a visible buildup suggesting impaired removal of waste or deficits in detoxification on the right?", "Does the image indicate increased pressure upstream of a possible right-sided obstruction?", "Are there visual clues of pressure redistribution or dysregulation within the system on the right side?", "Can you identify uneven distribution of nutrients or hormones in tissues associated with the right side?"]}, "no_questions": {"contexual_properties": ["Can you identify a region where tissue appears dead or pale, which could be due to insufficient blood supply and necrosis?", "Does the mass appear softer or firmer in certain regions, possibly due to necrosis, cystic change, or fibrotic tissue formation?", "Does the mass seem to extend beyond its apparent margins, indicating invasion into surrounding tissues?"], "properties": ["Does the image reveal a mass with density greater than the surrounding tissue, but with some regions that appear less dense or cystic?", "Does the image show a region where cellular proliferation appears to be high, as indicated by numerous mitotic figures?", "Can you see a mass that may have elevated lipid content, such as one resembling a lipogenic tumor?"], "relational": ["Can you observe a structure that invades neighboring tissues like muscle, fat, blood vessels, nerves, or adjacent organs?", "Does the image show a mass that could originate from epithelial, connective, muscle, or nervous tissue?", "Does the image contain a mass that might include neoplastic, stromal, immune, or endothelial cells?"], "contexual_behavior": ["Can you identify a mass that could resist cell death under nutrient deprivation by activating survival pathways?", "Does the image display a mass that appears to compress nearby blood vessels, potentially causing vascular obstruction or ischemia in surrounding tissues?", "Is there a structure in the image that could show increased metabolic activity and enhanced glycolysis in areas with limited oxygen supply?"], "functions": ["Can you identify secondary complications like edema or ulceration that might result from disrupted vascular or lymphatic flow?", "Do you observe areas with altered metabolic activity, such as regions of hypoxia or tissue changes suggestive of increased metabolic demand?", "Can you see indications of impaired lymphatic drainage, such as swelling or fluid accumulation consistent with lymphedema?"]}}, "lesion": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an area in the image that varies in size from a few millimeters to several centimeters?", "Can you identify a region with a round, oval, irregular, or linear shape?", "Does the image show any area with colors such as red, brown, black, white, or skin-colored?", "Is there a structure with a smooth, rough, scaly, or verrucous texture visible?", "Can you see a region with well-defined or ill-defined borders?", "Is there an area that appears superficial, partial-thickness, or full-thickness in depth?", "Does the image contain a region that looks soft, firm, hard, or fluctuant?", "Can you identify a surface that is flat, raised, depressed, or ulcerated?", "Is there a region whose volume appears variable based on its size and depth?", "Does any area seem to have increased temperature, possibly indicating inflammation or infection?", "Can you see a region that appears dry, moist, or exudative?", "Is there a structure that looks soft or hard, suggesting differences in firmness?", "Can you identify an area where the tissue appears to have decreased, normal, or increased elasticity?", "Does the image show a region that could be composed of cells, fluid, necrotic tissue, or fibrous material?", "Is there an area with low, intermediate, or high density as might be seen on imaging or by palpation?", "Can you see a region with uniform, variegated, or absent pigmentation patterns?", "Is there a surface that appears non-ulcerated or ulcerated?", "Does any area show signs of low, moderate, or high vascularity, such as increased redness or bleeding tendency?", "Can you identify a region with absent, scant, moderate, or copious exudate?", "Is there an area that appears to be growing slowly, moderately, or rapidly compared to surrounding tissue?"], "relational": ["Is there an area within the image where the structure of epithelial, connective, muscle, or nervous tissue appears altered?", "Can you identify a region in the skin, liver, brain, lung, or kidney that looks abnormal compared to the surrounding tissue?", "Does the image show any abnormality in regions such as the oral cavity, gastrointestinal tract, central nervous system, or skin?", "Is there a localized area that is surrounded by parenchyma, stroma, blood vessels, or a basement membrane?", "Can you see a region containing cells that resemble inflammatory, neoplastic, fibroblastic, or necrotic cell types?", "Does the image reveal a disruption in the structure or function of the nervous, respiratory, digestive, or integumentary system?", "Is there evidence of tissue disruption, infiltration, or inflammation in any part of the image?", "Can you identify a region with distinct margins, a capsule, or a clear interface with normal tissue?", "Does the image contain a structure that could be related to a tumor, ulcer, scar, or abscess?", "Is there an area involving specific tissue layers such as the epidermis, dermis, submucosa, muscularis, or subcutaneous tissue?"], "contexual_behavior": ["Is there a structure in the image that might heal more slowly if immune function is impaired?", "Can you identify an area that could increase in size during chronic inflammation?", "Does the image show a region where normal tissue regeneration might fail if fibrosis predominates?", "Is there a feature that could exhibit reduced repair activity in the context of diabetes mellitus?", "Can you see an area that might be more prone to infection in an immunocompromised state?", "Does the image contain a region that could demonstrate accelerated healing after therapeutic intervention?", "Is there a structure that might show impaired vascularization in a hypoxic environment?", "Can you identify an area that could persist due to ongoing exposure to toxins?", "Does the image show a region where increased scarring might occur during abnormal wound healing?", "Is there a feature that could fail to resolve in the presence of autoimmune disease?", "Can you see an area that might become more active following acute trauma?", "Does the image contain a region that could demonstrate decreased cellular turnover in aging tissue?", "Is there a structure that might exhibit delayed closure under malnutrition?", "Can you identify an area that could show increased inflammatory response during infection?", "Does the image show a region that might fail to repair due to poor blood supply?"], "functions": ["Does the image show an area of abnormal tissue change or damage?", "Is there a region where normal tissue architecture appears disrupted?", "Can you identify a structure that might impair the function of the surrounding tissue?", "Is there evidence of altered cell proliferation or increased cell death in a specific area?", "Does the image reveal signs of local inflammation, such as immune cell infiltration?", "Can you see a region that could be activating local immune responses?", "Is there an area where tissue repair or regeneration might be occurring, such as the presence of healing cells?", "Does the image show features suggesting the release of cytokines or growth factors in a localized region?", "Is there a visible abnormality that could compromise the function of an organ or tissue?", "Can you identify a region that might be contributing to chronic inflammation or disease progression?", "Is there evidence of vascular or lymphatic obstruction, such as localized swelling or impaired drainage?", "Does the image show an area that could be causing pain or altered sensation by affecting nerve endings?", "Can you see signs of protective responses like clot formation or increased immune activity in a specific region?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image include anatomical sites commonly used for diagnosis, such as bone marrow, peripheral blood, or cerebrospinal fluid?", "Does the image suggest disruption of normal hematopoiesis within the bone marrow?", "Is there evidence of a process originating from lymphoid progenitor cells within the lymphatic system?"], "contexual_behavior": [], "functions": ["Is there visual evidence of abnormal expansion of lymphoblasts in blood or tissue samples?", "Does the image reveal replacement of normal bone marrow elements with abnormal cells?", "Is there visual indication of immune system compromise, such as a decreased presence of functional lymphocytes?"]}}, "odontoid process subluxation": {"yes_questions": {"contexual_properties": ["Does the image show abnormal alignment at the atlantoaxial joint that could be worsened by trauma or inflammatory arthritis?", "Is there evidence of increased displacement between the first and second cervical vertebrae that might indicate ligament injury or instability?", "Can you identify signs of abnormal joint space width that could suggest synovial inflammation or joint effusion?", "Does the image reveal narrowing of the spinal canal due to posterior displacement of a cervical structure, potentially compressing the spinal cord?", "Are there visible changes in bone structure, such as remodeling or erosion, that might result from chronic instability?", "Is there swelling of tissues around the upper cervical spine that could be due to acute trauma or an inflammatory response?", "Can you see an increased gap between the atlas and a peg-like projection, possibly indicating rupture or laxity of the transverse ligament?", "Does the cervical spine show abnormal curvature that could be a compensatory change from chronic misalignment?", "Are there features suggesting weakened or degenerated ligaments supporting the atlantoaxial joint?", "Is there evidence of bone erosion at the atlantoaxial joint that could be associated with chronic inflammation or rheumatoid arthritis?", "Can you identify signs of increased joint laxity in the upper cervical region, possibly related to connective tissue disorders?", "Are there imaging findings such as sclerosis or pannus formation that would indicate chronic changes at the atlantoaxial joint?", "Does the image appear to be taken during flexion or extension, or does it use advanced imaging modalities like MRI to better reveal instability at the upper cervical spine?"], "properties": ["Does the image show a structure with displacement measuring between 3 and 5 millimeters?", "Is there evidence of angulation at the atlantoaxial joint in the range of 10 to 20 degrees?", "Can you identify anterior or posterior translation between C1 and C2 that is less than 5 millimeters?", "Is the atlantodental interval greater than 3 millimeters in an adult or greater than 5 millimeters in a child?", "Does the image reveal malalignment or a step-off between the anterior arch of the atlas and an adjacent bony process?", "Is there any sign of bone edema that might indicate an acute or traumatic injury on MRI?", "Can you observe cortical irregularity in a region that could be affected by chronic inflammatory conditions such as rheumatoid arthritis?", "Does the MRI show low signal intensity on T1-weighted images and high signal on T2-weighted images in a relevant bony structure, suggesting edema?", "Is there prevertebral soft tissue swelling greater than 6 millimeters at the level of the second cervical vertebra in an adult?", "Can you see abnormal alignment with anterior or posterior displacement of a bony process relative to the anterior arch of the atlas?"], "relational": ["Is there evidence of abnormal alignment at the joint connecting the first and second cervical vertebrae?", "Does the image show any displacement involving the upper cervical spine?", "Can you identify any irregular relationship between the atlas and axis bones?", "Is there a visible disruption of the articulation between the anterior arch of the atlas and the structure projecting from the axis?", "Does the image suggest involvement of ligaments such as the transverse ligament or alar ligaments in the upper cervical region?", "Is there any indication that joint capsules or neural tissue near the upper cervical spinal cord segments might be affected?", "Can you see any abnormal proximity or compression of the spinal cord adjacent to the first and second cervical vertebrae?", "Is there a structure in the axial skeleton of the musculoskeletal system that appears misaligned at the level of C1 and C2?", "Does the image reveal any alteration in the position of tissues near the tectorial membrane or anterior arch of the atlas?"], "contexual_behavior": ["Does the image show evidence of instability in the upper cervical spine, such as abnormal alignment between the first and second cervical vertebrae?", "Can you identify any signs of displacement at the atlantoaxial joint that might compromise ligamentous support?", "Is there visible narrowing of the spinal canal at the C1-C2 level that could increase the risk of spinal cord compression?", "Does the image suggest reduced range of motion or stiffness in the neck due to abnormal joint positioning?", "Are there features consistent with inflammatory changes, such as those seen in rheumatoid arthritis, affecting the atlantoaxial region?", "Can you see any indications of neural structure compression that might lead to impaired neural transmission or nerve root involvement?", "Is there evidence of vascular compromise, such as compression of the vertebral artery, that could affect blood flow to the brainstem?", "Does the alignment of the cervical vertebrae suggest disruption of normal proprioceptive feedback from the neck?", "Are there signs that trauma or sudden movement has resulted in increased mechanical stress or instability at the atlantoaxial joint?", "Can you identify features that might indicate compromised respiratory function due to involvement of neural pathways controlling respiratory muscles?", "Is there any indication of neural compression at the cervicomedullary junction that could impair swallowing or vocalization?", "Does the image show abnormal joint movement or tissue irritation that could be associated with increased pain during neck rotation?", "Are there signs of ligamentous laxity or structural weakness reducing the effectiveness of cervical spine support structures?", "Can you see evidence of dynamic instability or transient compression of neural elements that might occur during physical activity?", "Does the image reveal malalignment of the atlantoaxial joint under mechanical stress, suggesting ligamentous insufficiency?", "Are there indications that immobilization or surgical stabilization has been used to restore normal alignment and prevent further displacement in the cervical spine?"], "functions": ["Does the image show evidence of instability in the cervical spine that could increase the risk of abnormal vertebral motion or spinal cord injury?", "Is there a visible indication of spinal cord compression or stretching that might result in impaired motor or sensory function below a certain level?", "Can you identify any signs of mechanical deformation or ischemia in the cervical spinal cord that could disrupt neural signal transmission?", "Does the image suggest restricted or altered head and neck movement due to instability, pain, or a mechanical blockage?", "Is there any evidence of vertebral artery compression or kinking that could compromise blood flow and increase the risk of ischemic events?", "Can you see features that might contribute to neurological deficits such as weakness, numbness, or paralysis by damaging neural structures in the cervical region?", "Does the image reveal any impairment of respiratory function that could be linked to neural control disruption or direct compression of the medulla?", "Is there any indication of disrupted proprioceptive feedback from the cervical spine, such as abnormal joint alignment or altered sensory input?", "Can you identify signs of impaired protective reflexes in the neck, such as issues with the head righting reflex, due to instability or altered neural signaling?", "Does the image show abnormal alignment or biomechanics of the cervical vertebrae that could lead to uneven load distribution or increase the risk of degenerative changes?"]}, "no_questions": {"contexual_properties": ["Does the image show evidence of extensive tissue damage that could result from a major thermal injury?", "Is there visible disruption of the skin barrier that might indicate a critical loss of protective function?", "Can you identify signs of widespread injury that could lead to fluid loss or risk of infection?"], "properties": ["Can you identify visual signs consistent with a critical injury that may have occurred approximately one day ago?", "Is there evidence of widespread skin loss or charring that could indicate a severe acute injury?", "Does the image show evidence of extensive tissue damage affecting a large portion of the body?"], "relational": ["Can you see signs of tissue damage extending to the hypodermis?", "Does the image reveal exposure of deeper structures such as subcutaneous fat, muscle, or even bone?", "Is there any indication of impaired immune response, such as signs of infection or inflammation in the affected areas?"], "contexual_behavior": [], "functions": ["Can you identify visual signs consistent with a severe injury that may have occurred approximately one day ago?", "Does the image show evidence of extensive tissue damage affecting a large area of the body?", "Is there visible disruption of the skin barrier over a significant portion of the body surface?"]}}, "eye": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": [], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for detecting light and forming images?", "Can you identify an area containing photoreceptor cells such as rods and cones?", "Is there evidence of a region where light is focused onto a surface for signal transmission to the brain?", "Does the image include a component that changes shape to adjust image clarity, possibly through the action of ciliary muscles?", "Can you see a part that alters its opening size to adapt to different light intensities, likely involving the iris?", "Is there a structure that contributes to color vision by containing cells sensitive to different wavelengths?", "Does the image suggest the presence of paired structures that could enable depth perception through binocular vision?", "Can you identify muscles around a spherical structure that might coordinate its movement for tracking objects?", "Is there evidence of protective features such as eyelids, eyelashes, or a tear film?", "Does the image show glands or ducts that could be involved in tear production and ocular lubrication?", "Can you see a pathway or connection that might transmit visual signals to the brain, such as an optic nerve?", "Is there a structure that could provide visual input to assist with balance and spatial orientation?", "Does the image suggest a role in regulating circadian rhythms by transmitting light information to the brain?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see any features suggesting involvement of blood vessels like the radial or femoral artery near a damaged area?", "Is there evidence of structural damage affecting bones such as the radius, femur, or clavicle?", "Can you identify an area where the periosteum or surrounding soft tissue appears altered or disrupted?"], "contexual_behavior": ["Can you see a bone injury located in an avascular region where impaired vascularization might lead to poor healing?", "Does the image show a bone lesion that could demonstrate altered healing in the presence of systemic inflammation?", "Can you see a bone injury that might fail to remodel correctly in the context of osteoporosis or decreased bone density?"], "functions": ["Does the image reveal any features suggestive of impaired mobility or instability in a limb or joint?", "Does the image show evidence of disruption in the continuity of a bone structure?", "Does the image suggest loss of normal anatomical alignment or function in a skeletal region?"]}}, "side showing patency": {"yes_questions": {"contexual_properties": ["Is there a region in the image where a vessel appears narrowed, suggesting possible stenosis or atherosclerosis?", "Can you identify an area where a vessel seems obstructed by a thrombus or embolus?", "Does the image show a vessel segment with increased diameter, as seen in aneurysm or dilation?", "Is there evidence of vessel constriction, such as decreased diameter due to vasoconstriction or spasm?", "Do you observe any vessel walls that appear irregular, possibly indicating vascular injury or inflammation?", "Is there a vessel segment displaying abnormal tissue growth, such as neoplasm or intimal hyperplasia?", "Can you see a vessel that appears less flexible, possibly due to fibrosis or calcification?", "Does the image show a vessel with increased resistance to flow, such as narrowing from plaque or thrombus?", "Is there a vessel that appears dilated, which could be a response to chronic hypertension or wall weakness?", "Do you notice any changes in vessel color, such as pallor, cyanosis, or hemorrhage?", "Is there visible accumulation of debris or plaque within a vessel, suggesting chronic vascular disease?", "Can you identify a vessel that appears compressed by an external mass, tumor, or edema?", "Does the vessel wall appear thickened, possibly due to chronic inflammation or hypertrophy?", "Is there a segment of a vessel that seems blocked by thrombus, embolus, or severe plaque formation?", "Do you observe decreased blood flow in a vessel, as might occur with stenosis or vascular spasm?"], "properties": ["Does the image show a channel or lumen that appears open and unobstructed?", "Can you identify a structure with a round or tubular shape, consistent with a healthy vessel or duct?", "Is there a passage whose diameter falls within the expected physiological range for its type?", "Does the image contain a structure with a pinkish or pale color, indicating healthy tissue?", "Can you see a channel whose width matches the normal anatomical standard for that vessel or duct?", "Is there a tubular structure whose length corresponds to the typical anatomical course of such vessels or ducts?", "Does the image show a surface that appears smooth and regular, suggesting an intact lining or endothelium?", "Can you identify a cross-sectional area that matches the physiological range for the vessel or duct depicted?", "Is there a lumen whose size appears within the normal range for its anatomical structure?", "Does the wall thickness of any visible vessel or duct appear consistent with healthy, non-diseased tissue?"], "relational": ["Does the image display a segment of a vessel or duct that appears open and unobstructed?", "Can you identify a surface within the cardiovascular, lymphatic, or digestive system that maintains an open channel?", "Is there a region in the thorax, abdomen, limbs, or neck where a vessel or duct remains patent?", "Does the image show a structure adjacent to surrounding tissues or neighboring vessels with a visible open lumen?", "Can you see an artery, vein, bile duct, or ureter that is free of obstruction?", "Is there evidence of endothelium, smooth muscle, or connective tissue lining an open channel?", "Does the image allow assessment of lumen diameter or the absence of blockage in a vessel or duct?", "Can you observe blood flow or fluid movement indicating an unobstructed pathway?", "Is there a structure connected to the heart, liver, kidneys, or lungs that demonstrates patency?", "Does the image show a vessel or duct that enables fluid flow, nutrient transport, or waste removal?", "Can you identify vessel walls, duct linings, or adjacent tissue planes that define an open segment?"], "contexual_behavior": ["Is there a region where normal flow appears to be lost due to complete blockage or severe narrowing of a vessel?", "Can you identify an area where swelling or infiltration of inflammatory cells might be causing reduced openness of a vessel?", "Does the image show evidence of a blood clot obstructing a vessel lumen, leading to impaired flow?", "Is there a side where flow capacity seems increased following an intervention such as angioplasty or surgical bypass?", "Can you see a vessel segment with decreased openness that could be explained by transient constriction of vascular smooth muscle?", "Is there a location where surgical repair appears to have failed due to restenosis or scarring at the repair site?", "Does the image show a vessel where patency seems improved, possibly as a result of anticoagulant therapy promoting recanalization?", "Is there a vessel segment compromised by plaque buildup, suggesting narrowing due to atherosclerosis?", "Can you identify an area where normal flow has been restored after removal of an obstruction such as a thrombus or embolus?", "Does the image show reduced flow in a vessel segment that could be attributed to external compression from a mass or tight bandage?", "Is there evidence of altered vessel behavior that might be associated with infection or sepsis, such as endothelial dysfunction or microvascular changes?", "Can you see a vessel with decreased openness that may be due to chronic inflammation, ongoing tissue damage, or fibrosis?", "Is there a region where a stent appears to be holding a vessel open, resulting in increased patency?", "Does the image show a vessel with decreased openness that could be explained by reduced blood volume or collapse from dehydration or hypovolemia?", "Is there a vessel segment where recovery has failed after trauma or injury, possibly due to persistent damage or inadequate healing?"], "functions": ["Does the image show a vessel or lumen that appears open and unobstructed, allowing for normal flow?", "Can you identify a structure that would permit blood to flow freely, supporting effective circulation?", "Is there evidence of vessel integrity being maintained, with no signs of collapse or blockage?", "Does the image suggest that tissue perfusion and oxygenation are being adequately supported by continuous blood delivery?", "Can you see features that indicate the prevention of vascular obstruction, reducing the risk of ischemia or infarction?", "Is there a vessel or lumen that appears to be supporting organ function by ensuring sufficient blood supply?", "Does the image show uninterrupted pathways for nutrient delivery to tissues?", "Can you identify a structure that would facilitate the removal of metabolic waste through effective blood flow?", "Is there visual evidence suggesting successful restoration or preservation of vessel openness, as might be assessed after surgery?", "Does the image indicate support for normal physiological processes through continuous circulation and maintenance of homeostasis?"]}, "no_questions": {"contexual_properties": ["Does the image contain any lesions with characteristics typical of a malignant tumor?", "Can you identify any structures that might represent a malignant neoplasm?", "Does the image show any abnormal growths that could indicate a malignant process?"], "properties": ["Does the image show any abnormal growths or masses that could indicate a malignant process?", "Can you identify any structures that might represent a malignant neoplasm with cystic characteristics?", "Is there evidence of a lesion with features suggestive of cancerous transformation?"], "relational": ["Can you identify a structure located within the abdominal or pelvic cavity that appears abnormal?", "Is there a mass adjacent to anatomical structures like the peritoneum, mesentery, or nearby blood vessels?", "Are there signs of involvement of regional lymph nodes or lymphatic vessels near an abnormal structure?"], "contexual_behavior": ["Can you identify any structures that may represent a malignant neoplasm?", "Does the image show any abnormal masses that could indicate a malignant process?", "Is there evidence of a lesion with features suggestive of cancerous growth?"], "functions": ["Are there signs of a remodeled stroma or increased inflammation in the local tissue environment?", "Is there any indication that malignant cells are evading immune detection, such as reduced immune cell infiltration?", "Does the image show cystic or glandular structures that could result from aberrant epithelial differentiation or mucin production?"]}}, "patent": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears thickened, possibly due to inflammation or fibrosis?", "Can you identify any narrowing of a tubular structure that might suggest stenosis or external compression?", "Does the image show a vessel-like structure with an altered diameter, such as dilation or constriction?", "Is there evidence of increased permeability, such as swelling or edema, that could indicate endothelial dysfunction or injury?", "Can you see any signs of obstruction, such as a blockage that might be caused by a thrombus or embolus?", "Are there any irregularities in the walls of a vessel-like structure, possibly due to chronic inflammation or malformation?", "Does the image reveal altered flow patterns, such as turbulence or narrowing, within a vessel?", "Is there a visible dilation of a vessel, which could suggest aneurysm formation or chronic hypertension?", "Can you observe any changes in the structural integrity of a vessel, such as degeneration or trauma?", "Is there evidence of abnormal tissue within a vessel, such as lipid or calcium deposits?", "Does any vessel-like structure appear less flexible, possibly due to fibrosis or calcification?", "Are there signs of increased pressure within a vessel, such as distension or outflow obstruction?", "Can you identify calcification within a vessel, which may be associated with chronic inflammation or metabolic disease?", "Is there a thickened lining visible in a vessel, possibly due to chronic irritation or hyperplasia?", "Does the image show a tortuous vessel, which could be related to hypertension or vessel wall weakness?", "Are there any changes in color or appearance of a vessel-like structure, such as pallor or hemorrhage, that might indicate ischemia or inflammation?", "Can you see evidence of plaque formation or lipid accumulation within a vessel?", "Is there a vessel that appears less elastic, possibly due to aging or chronic disease?", "Does any vessel-like structure seem more fragile or prone to damage, perhaps due to degeneration or nutritional deficiencies?", "Are there signs of swelling or edema around a vessel, which could be caused by increased vascular permeability or impaired lymphatic drainage?"], "properties": ["Is there any feature in the image that cannot be described by physical properties such as length, width, or thickness?", "Can you identify an aspect in the image that is not associated with color, shape, or texture?", "Does the image contain any element that lacks measurable dimensions or material composition?", "Is there a feature present that cannot be characterized by density, temperature, or pH?", "Can you find something in the image that is described by a term rather than by its physical appearance or structure?"], "relational": ["Does the image show a structure that could be a blood vessel, duct, tube, or airway with an open passage?", "Is there a feature present that might belong to the cardiovascular, respiratory, digestive, or urinary system and appears unobstructed?", "Can you identify an open passageway in the thorax, abdomen, pelvis, or limbs?", "Does the image contain a vessel or tube with a visible lumen that interacts with surrounding connective tissue or smooth muscle?", "Is there a structure resembling a bile duct, ureter, trachea, bronchus, or fallopian tube that appears unobstructed?", "Can you see evidence of vascular continuity, ductal flow, or an open airway passage?", "Is there a structure such as an intestine, blood vessel, urethra, or esophagus that appears to maintain anatomical continuity through an open channel?", "Does the image include a component of the circulatory, respiratory, or gastrointestinal system that relies on an open passage for function?", "Can you identify an organ such as the heart, lungs, kidneys, intestines, or bladder with a visible open lumen?", "Is there a passageway bordered by epithelial tissue, smooth muscle, connective tissue, or adventitia that appears unobstructed?"], "contexual_behavior": ["Is there evidence of an invention whose protection has been lost due to invalidation following legal proceedings?", "Can you identify a situation where exclusive rights have ceased because the invention has entered the public domain after expiration?", "Does the image suggest that exclusive rights are not recognized in certain regions due to territorial limitations or lack of jurisdiction?", "Is there an indication of unauthorized use occurring during ongoing litigation, possibly due to the absence of a preliminary injunction?", "Can you see a scenario where protection is limited because authorities have imposed compulsory licensing to ensure access during a public health emergency?", "Is there a case where the incentive for innovation has decreased after full disclosure, allowing competitors to use the disclosed information post-expiration?", "Does the image show a situation where the discovery of prior art has weakened exclusivity, potentially leading to invalidation?", "Is there evidence that revenue generation has declined due to the entry of generic products following loss of exclusivity?", "Can you identify a context where technology transfer is facilitated through collaboration, such as licensing agreements or joint ventures?", "Is there a scenario where the defensive function has been impaired because the protective effect was removed after a legal challenge or opposition?"], "functions": ["Does the image show a structure that appears open and unobstructed, allowing for normal passage or flow?", "Can you identify an anatomical pathway that would permit the movement of fluids or gases?", "Is there evidence of a channel or lumen that is maintained in an open state to support physiological function?", "Does the image suggest the presence of a structure that could facilitate adaptive responses such as increased blood flow or secretion?", "Can you see a vessel or duct whose openness would be important for the success of an intervention like stent placement or drainage?", "Is there a feature in the image that would support homeostasis by ensuring unobstructed transport within the body?", "Does the image contain an anatomical structure whose functional integrity depends on being unobstructed?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a structure whose weight could plausibly range from 20 to 200 grams?", "Is there a mass in the image that measures between 2 and 10 centimeters at its largest dimension?", "Does the image show a lesion that appears round, oval, or lobulated in shape?"], "relational": ["Is there a structure present that could compress or displace the heart, lungs, trachea, or esophagus?", "Does the image reveal a mass arising from or closely related to the thymus gland?", "Is there a structure whose anatomical boundaries are defined by the sternum anteriorly, pericardium posteriorly, lungs laterally, thoracic inlet superiorly, and diaphragm inferiorly?"], "contexual_behavior": [], "functions": ["Can you identify an abnormality that could interfere with T cell development or maturation?", "Is there a structure that could compromise immune tolerance by allowing self-reactive T cells to escape into the periphery?", "Can you identify a mass whose presence could lead to immunodeficiency or increased susceptibility to infections?"]}}, "leiomyoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a mass located within an organ of the reproductive, gastrointestinal, or urinary system?", "Can you identify a lesion arising from tissue composed of smooth muscle?", "Is there a structure adjacent to the endometrium, myometrium, or serosa visible in the image?", "Does the image contain a mass primarily made up of smooth muscle cells or fibroblasts?", "Can you see a tumor-like structure in the uterus, small intestine, esophagus, or skin?", "Is there a growth originating from the smooth muscle layer of the uterus?", "Does the image show a mass arising from layers such as the myometrium, muscularis propria, or tunica media?", "Can you identify a lesion with blood supply from vessels like the uterine artery or branches of the internal iliac artery?", "Is there a structure surrounded by a pseudocapsule or dense collagen fibers?", "Does the image show a mass located in the uterine body, cervix, or broad ligament?"], "contexual_behavior": ["Does the image show a structure whose growth might accelerate during pregnancy due to increased sex steroid hormones?", "Is there evidence of a mass that could be more responsive to estrogen and progesterone during the reproductive years?", "Can you identify a lesion that would likely reduce in size after menopause when ovarian hormone production declines?", "Does the image contain a structure that could impair uterine contractility during menstruation by disrupting normal myometrial function?", "Is there a mass that might alter its vascular supply under hypoxic conditions by promoting angiogenesis or vascular remodeling?", "Can you see a lesion that would decrease its metabolic activity in response to hormonal therapy such as GnRH agonists?", "Is there a structure that could increase extracellular matrix production in response to inflammation through fibroblast activation?", "Does the image show a mass that might distort the endometrial cavity and affect hemostasis during episodes of heavy menstrual bleeding?", "Is there a lesion whose proliferative activity would be reduced after treatment with GnRH agonists due to hormonal suppression?", "Can you identify a structure that might increase local estrogen production in obese individuals because of enhanced aromatase activity in adipose tissue?", "Does the image contain a mass that could impair fertility by altering the uterine environment, including endometrial receptivity and embryo implantation?", "Is there evidence of a lesion that increases angiogenic activity during rapid growth phases to support tissue expansion?", "Can you see a structure that might decrease its responsiveness to progesterone in the context of chronic inflammation due to altered receptor expression?", "Is there a mass that could alter uterine blood flow during physical exertion by compressing adjacent vessels and modifying vascular resistance?", "Does the image show a lesion that might increase cytokine secretion in response to tissue injury, contributing to local inflammation and tissue remodeling?"], "functions": ["Does the image show a benign growth originating from smooth muscle tissue?", "Is there evidence of a mass that could disrupt the normal contractile function of the uterus?", "Can you identify a structure that might distort the architecture of the myometrium?", "Does the image contain a lesion that could increase or irregularize menstrual bleeding by altering the endometrial surface or vascular supply?", "Is there a mass that could interfere with embryo implantation or contribute to infertility by distorting the uterine cavity?", "Can you see a structure that might compress or increase blood vessels, potentially altering local blood flow?", "Is there evidence of tissue displacement, compression, or hypertrophy of adjacent smooth muscle fibers?", "Does the image show a mass that could express hormone receptors and modify the local hormonal environment in the uterus?", "Is there a lesion that might cause pelvic pain or pressure symptoms by exerting a mass effect on surrounding pelvic structures?", "Can you identify a structure that could contribute to bulk-related pelvic symptoms such as discomfort, urinary frequency, or constipation?", "Does the image show a mass that could compromise normal uterine function, including menstruation, fertility, or contractility?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image display limbs with noticeably increased circumference, potentially by 5 to 10 centimeters or more?", "Does the image show swelling with a normal capillary refill time, typically less than 2 seconds?", "Is there visual evidence suggesting a marked increase in tissue water content, possibly exceeding 70% of tissue weight?"], "relational": ["Does the image show evidence of widespread fluid accumulation in the subcutaneous tissue?", "Are there signs of anatomical barriers, such as capillary endothelium or lymphatic vessels, being affected by fluid accumulation?", "Does the image display changes in the skin or mucous membranes that could be due to fluid buildup?"], "contexual_behavior": [], "functions": ["Does the image suggest reduced mobility or physical limitation as a result of extensive swelling or discomfort?", "Is there visible swelling that might be due to increased capillary permeability or fluid overload?", "Is there evidence of increased distance between capillaries and cells that could impair nutrient or oxygen delivery?"]}}, "narrowing of foramen magnum": {"yes_questions": {"contexual_properties": ["Does the image show evidence of abnormal bone growth or thickening at the craniovertebral junction?", "Can you identify a region where the diameter of a major cranial opening appears reduced compared to normal anatomy?", "Is there visible compression or deformation of neural or vascular structures near the base of the skull?", "Does the image reveal increased bone density or excessive bone deposition in the area where the skull meets the spine?", "Are there signs of altered bone composition suggestive of conditions like osteopetrosis or metabolic bone disease?", "Can you observe imaging findings that indicate a constricted aperture affecting cerebrospinal fluid flow?", "Is there evidence of impingement or deformation of the brainstem or upper spinal cord by adjacent bone structures?", "Does the image suggest rapid progression of bone changes, especially in a pediatric patient or in the context of an aggressive skeletal disorder?", "Are there radiographic or MRI features showing abnormal contours or margins of the cranial base opening?", "Can you see changes in the shape of the cranial opening that might result from bone remodeling or disease progression?", "Is there a visible reduction in the space available for neural or vascular structures at the craniovertebral junction?", "Does the image show features consistent with sclerosing bone dysplasia in the region where the skull and spine connect?", "Are there signs of compromised cerebrospinal fluid circulation due to a narrowed cranial base opening?", "Can you detect any deformation of adjacent anatomical structures resulting from bone overgrowth at the craniovertebral junction?"], "properties": ["Does the image show an opening at the base of the skull with a diameter less than 30 mm?", "Can you identify a structure whose width is below the normal range of 30 to 35 mm?", "Is there evidence of an opening with more than a 20% reduction in area compared to typical size?", "Does the sagittal diameter of the visible cranial opening appear to be less than 30 mm?", "Can you see a foramen with a transverse diameter under 25 mm?", "Is there an opening that appears more oval or constricted than the usual round or oval shape?", "Can you classify the degree of narrowing of the cranial opening as mild, moderate, or severe based on its dimensions?", "Does the cross-sectional area of the opening appear to be less than 500 mm\u00b2?", "Is there increased bone thickness at the margins of the opening, possibly exceeding 5 mm?", "Does the ratio of the opening's dimensions appear to be less than 0.8 compared to standard proportions?"], "relational": ["Is there evidence of a reduced opening at the cranial base where the medulla oblongata and vertebral arteries pass through?", "Can you observe any abnormal narrowing in the large aperture formed by the occipital bone?", "Does the image show any compression or crowding of structures such as the lower brainstem or upper spinal cord near the base of the skull?", "Is there a visible alteration in the continuity between the cranial cavity and the vertebral canal?", "Can you detect any signs of bony overgrowth or thickened tissues at the boundary of the occipital bone?", "Are there indications of congenital malformation affecting the area where the spinal cord exits the skull?", "Does the region adjacent to the cerebellum and clivus appear constricted?", "Is there any visible impact on the dura mater, arachnoid mater, or pia mater at the cranial base opening?", "Can you see any structural changes in the axial skeleton at the junction between the skull and vertebral column?", "Are the accessory nerves or vertebral arteries visibly compressed as they traverse the opening at the base of the skull?"], "contexual_behavior": ["Does the image show evidence of obstruction to cerebrospinal fluid flow between the cranial and spinal compartments?", "Is there any indication of increased risk for brainstem compression during head movement due to restricted space at the craniovertebral junction?", "Can you identify features suggesting reduced neural signal transmission between the brain and spinal cord at the craniovertebral junction?", "Does the image provide clues of impaired respiratory function during sleep, possibly due to compression of brainstem centers controlling breathing?", "Is there any sign of compromised blood flow to the brain during physical exertion, such as compression of vascular structures at the craniovertebral junction?", "Can you see evidence of decreased swallowing efficiency that might result from compression of lower cranial nerves at the craniovertebral junction?", "Does the image suggest exacerbation of symptoms during episodes of increased intracranial pressure, possibly due to a restricted outlet for CSF or blood flow?", "Is there any indication of impaired motor coordination in a pediatric subject, potentially due to compression of developing neural tracts during growth?", "Can you identify features that suggest reduced protective function of the craniovertebral junction during trauma, increasing vulnerability of neural structures?", "Does the image show signs of altered venous drainage from the brain, such as congestion from compression of venous sinuses or veins at the craniovertebral junction?", "Is there any evidence of impaired temperature regulation that could be explained by autonomic dysfunction from compression of descending fibers at the craniovertebral junction?", "Can you see features that would lead to more severe neurological deficits during infection or inflammation, possibly due to further reduction of available space for neural tissue?", "Does the image suggest increased risk of sudden cardiorespiratory compromise, such as compression of vital centers in the medulla during acute events?", "Is there any indication of disrupted growth and development of the nervous system, potentially due to chronic compression at the craniovertebral junction?", "Can you identify signs that the narrowing worsens during periods of rapid skeletal growth, such as disproportionate bone development further restricting the foramen\u2019s diameter?"], "functions": ["Does the image show evidence of compression of neural or vascular structures that could lead to impaired neurological function?", "Is there any indication of cerebrospinal fluid flow obstruction that might increase the risk of hydrocephalus or intracranial hypertension?", "Can you identify features suggesting disruption of neural signal transmission between the brain and spinal cord?", "Is there visible compromise of brainstem structures that could result in deficits in autonomic or motor control?", "Does the image reveal signs of impaired cerebrospinal fluid dynamics or venous outflow that could contribute to raised intracranial pressure?", "Is there any indication of compression affecting the medulla that might cause abnormal breathing or heart rate regulation?", "Can you see evidence of spinal cord compression at the junction with the skull, potentially leading to motor or sensory deficits below that level?", "Are there visual cues suggesting neurological symptoms such as headache, neck pain, ataxia, or weakness due to compromise of neural structures?", "Does the image show possible compression of cranial nerves that could result in dysphagia or vocal cord paralysis?", "Is there any indication of impaired movement or coordination that could be explained by dysfunction of cerebellar or corticospinal pathways?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an object that could contain iron at a concentration of 0.5 to 1.5 milligrams per gram of tissue?", "Does the image show an ovoid or wedge-shaped anatomical structure?", "Can you identify a structure that would be expected to have about 75% water content by weight?"], "relational": ["Can you identify an organ located in the left upper quadrant of the abdominal cavity?", "Is there evidence of tissues resembling white pulp or red pulp?", "Is there a structure associated with vascular channels such as sinusoids, but not directly with ducts?"], "contexual_behavior": [], "functions": ["Can you see evidence of increased lymphocyte proliferation and antibody synthesis in response to infection?", "Does the image show an organ that regulates the balance of white blood cells and platelets by sequestering and releasing them as needed?", "Is there a structure that facilitates the maturation and proliferation of lymphocytes within a specialized region?"]}}, "side": {"yes_questions": {"contexual_properties": ["Is there an area that appears swollen, possibly indicating trauma, infection, or inflammation?", "Can you observe any color changes that might suggest bruising, circulatory issues, or a skin disorder?", "Is there a region that looks tender, such as one affected by injury or localized infection?", "Do you see a lump that could be due to a cyst, tumor, or localized swelling?", "Is there evidence of bruising that might result from trauma or a bleeding disorder?", "Can you identify any discoloration that could be caused by hematoma, infection, or vascular compromise?", "Is there a visible increase in size that might be due to edema, mass formation, or inflammation?", "Do you notice a decrease in size that could indicate resolution of swelling, atrophy, or tissue loss?", "Is there any redness present that might be associated with inflammation, infection, or an allergic reaction?", "Can you see an area that appears warmer, possibly due to infection, inflammation, or increased blood flow?", "Is there a region that looks cooler, which could be caused by poor circulation, ischemia, or cold exposure?", "Do you observe a rash that might be related to allergy, infection, or a dermatological disease?", "Is there an area that appears firmer, suggesting fibrosis, mass formation, or swelling?", "Can you see a region that looks softer, possibly due to tissue breakdown, edema, or fat accumulation?", "Is there abnormal texture present, such as from scarring, edema, or a skin disorder?", "Do you notice any fluid accumulation that could indicate edema, seroma, or infection?", "Is there an indentation that might result from pressure, tissue loss, or scarring?", "Can you observe skin changes that could be due to dermatitis, infection, or chronic disease?", "Are there signs such as redness, warmth, swelling, or pus that might indicate infection?", "Do you see abnormal pigmentation that could be related to bruising, chronic skin conditions, or melanocytic changes?"], "properties": ["Is there a region in the image whose length and width appear variable depending on the anatomical structure?", "Can you identify an area where the thickness changes according to the tissue or organ present?", "Does the image show a surface whose area seems to depend on the size of the anatomical structure it belongs to?", "Can you see a region that appears either planar or curved, reflecting the contour of the associated anatomy?", "Is there a surface whose color matches that of the underlying tissue, such as pink for skin or red for muscle?", "Does the image display an area with a texture that could be smooth like serosa or rough like muscle fascia?", "Can you identify a region where the curvature varies depending on its anatomical location?", "Is there a visible area that would be expected to have a temperature around 36.5\u201337.5\u00b0C?", "Does the image show a region whose density could reflect soft tissue or bone, depending on the tissue type?", "Can you see an area composed of epithelial tissue, connective tissue, or muscle fibers?", "Is there a region that likely contains 60\u201380% water content, as seen in soft tissues?", "Does the image display a surface that would be expected to have a pH between 6.8 and 7.4?", "Can you identify an area where elasticity might vary, being greater in connective tissue than in other types?", "Is there a region whose hardness ranges from soft, like skin or muscle, to hard, like bone, depending on the anatomical structure?"], "relational": ["Does the image show structures that are mirrored on both halves of the body?", "Can you identify paired organs such as kidneys or lungs on opposite sides?", "Are there visible features that are lateral, positioned away from the midline?", "Does the image include bones like the humerus or femur present on both the left and right?", "Can you see muscles such as the deltoid or biceps brachii on each half of the body?", "Is there evidence of bilateral symmetry in the arrangement of anatomical structures?", "Are there nerves, such as the sciatic or facial nerves, distributed on both sides?", "Does the image depict regions separated by a midsagittal or parasagittal plane?", "Can you identify limbs or eyes located on both the left and right sides?", "Are there lateral anatomical features that distinguish the left from the right in the image?", "Does the organization of the musculoskeletal or nervous system appear to be side-specific?", "Can you see adrenal glands or ovaries distributed on each half of the body?", "Are there lymphatic structures arranged according to the sides of the body?", "Does the image show paired bones such as the radius, ulna, or fibula on both sides?", "Can you identify external oblique muscles on both the left and right?"], "contexual_behavior": ["Does the image show evidence of compromised musculoskeletal structures, such as muscles or ribs, that could affect posture support on one lateral aspect of the body?", "Is there any indication of trauma disrupting the thoracic or abdominal wall, potentially reducing protection for internal organs on one side?", "Can you observe signs of muscle weakness in the lateral trunk, such as impaired oblique muscles, that might limit trunk movement?", "Does the image suggest impaired lateral flexion or abnormal motor control of trunk muscles, possibly due to a neurological disorder?", "Is there evidence of altered balance or posture that could be related to disrupted sensory input for spatial orientation, as seen in vestibular dysfunction?", "Can you identify reduced sensory response or changes in the skin or nerves along the lateral body, which might indicate peripheral nerve damage?", "Does the image show increased muscular activity or compensatory movement on one lateral aspect, possibly due to weakness or injury on the opposite side?", "Is there a visible rib fracture or discontinuity in the rib cage that could impair force transmission along one lateral region?", "Can you see signs of restricted expansion of the lateral thoracic wall, which might suggest changes in respiration as seen in restrictive lung disease?", "Does the image reveal impaired coordination or asymmetry in movement of the lateral trunk, possibly resulting from damage to neural pathways after a stroke?"], "functions": ["Does the image show a lateral region that separates the front and back aspects of the body?", "Can you identify an area that provides structural support along the body's side?", "Is there a region visible that allows for lateral bending or movement, possibly involving oblique muscles?", "Does the image include a part of the rib cage or muscular wall that helps protect internal organs such as the lungs or liver?", "Can you see structures that house muscles assisting in thoracic expansion during breathing?", "Is there a region that appears to stabilize the trunk or support the alignment of the vertebral column?", "Does the image show an area where trunk rotation or lateral bending could be facilitated by coordinated muscle contraction?", "Can you identify attachment points for muscles like the latissimus dorsi or serratus anterior involved in movement coordination?", "Is there a region that may contain cutaneous nerves responsible for transmitting touch, pain, or temperature sensations from the skin?"]}, "no_questions": {"contexual_properties": ["Does the image show a region where the tissue response is more pronounced in the context of tumor progression or active injury?", "Can you identify increased myofibroblast presence within the stroma, as might be seen during wound healing or fibrotic progression?", "Does the image display increased fibrosis in areas suggestive of persistent injury or fibrogenic signaling?"], "properties": ["Does the image contain an area with a small amount of extracellular matrix?", "Can you identify a region with minimal infiltration by inflammatory cells?", "Does the supporting tissue appear thin, without significant expansion beyond the baseline structure?"], "relational": ["Are there areas where the proliferation or activation of connective tissue is minimal?", "Can you identify carcinoma nests or malignant glands that lack a prominent fibrous response?", "Does the image show epithelial or tumor tissue with minimal surrounding connective tissue reaction?"], "contexual_behavior": ["Does the image suggest impaired tissue remodeling after surgery, with suboptimal reorganization of the affected area?", "Does the tissue display inadequate scar formation, suggesting insufficient reparative stroma?", "Can you detect altered signaling or communication between stromal and parenchymal cells in the tissue?"], "functions": ["Is there minimal interaction or support between supporting tissue and epithelial cells, possibly indicating epithelial independence?", "Does the tissue display decreased paracrine or autocrine signaling between supporting and other cells, suggesting cellular quiescence?", "Does the image show tissue with minimal activation or proliferation of supporting cells, suggesting stromal inactivity?"]}}, "nose left side": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling on one side of the nasal structure that could suggest trauma, infection, allergy, or inflammation?", "Do you observe redness localized to one side of the nose, possibly indicating inflammation, infection, rosacea, or increased blood flow?", "Can you identify any discoloration, such as bruising or abnormal vascular patterns, affecting one lateral aspect of the nose?", "Is there an area on one side of the nose that appears enlarged, which might be due to edema, a mass, or acute inflammation?", "Does the image show a reduction in size or volume on one side of the nose, potentially following the resolution of swelling, tissue loss, or surgery?", "Are there any visible changes in skin texture, such as roughness or scarring, affecting one side of the nasal region?", "Can you see signs of tenderness, such as swelling or redness, on one side of the nose that might be associated with cellulitis, abscess, or trauma?", "Is there a lesion or ulcer present on one lateral aspect of the nose that could be due to skin cancer, infection, or autoimmune disease?", "Do you notice pallor or a pale appearance on one side of the nose, which could suggest anemia, vasoconstriction, or Raynaud's phenomenon?", "Is there any indication of increased warmth or erythema on one side of the nose, possibly reflecting local infection or acute inflammation?", "Can you observe crusting on one side of the nose that might be related to chronic rhinitis, eczema, or bacterial infection?", "Does the image reveal dryness or flakiness affecting one side of the nasal area, potentially due to environmental exposure, dermatitis, or dehydration?", "Is there visible edema or puffiness on one side of the nose, which could be a response to allergy, trauma, or infection?", "Are there signs of increased vascularity, such as prominent blood vessels, on one side of the nose that might be seen in rosacea, inflammation, or neoplastic conditions?", "Do you see any nodules or masses on one lateral aspect of the nose that could represent a benign tumor, cyst, or malignancy?", "Is there any deformation or abnormal shape of one side of the nose, possibly resulting from trauma, congenital anomaly, or tumor invasion?", "Can you detect abnormal secretions or discharge emerging from one side of the nose, which might indicate infection, allergic rhinitis, or sinusitis?", "Does the contour of one side of the nose appear disrupted or irregular, potentially due to trauma, surgery, or tissue necrosis?", "Are there signs of skin breakdown, such as ulceration or open sores, on one side of the nose that could be caused by pressure, infection, or chronic inflammation?", "Do you observe any pigmentation changes, such as darkening or uneven color, on one side of the nose that might be due to post-inflammatory hyperpigmentation, melasma, or sun exposure?"], "properties": ["Is there a structure visible that occupies approximately half the width and length of the nasal region?", "Can you identify an area on the face where the width measures about 1.5 to 2 centimeters in an adult?", "Does the image show a region extending from the nasal root to the tip with a length of about 2.5 to 3.5 centimeters?", "Is there a part of the nose that follows a convex or straight contour matching the overall nasal shape?", "Can you see a skin area on the nose that ranges in color from light pink to brown, depending on pigmentation?", "Is there a region containing layers such as skin, subcutaneous tissue, cartilage, bone, and mucosa?", "Does the image show an area likely composed of cell types like keratinocytes, melanocytes, fibroblasts, chondrocytes, and endothelial cells?", "Can you identify a region where the skin thickness appears to be about 1 to 2 millimeters?", "Is there a visible area that could contain lateral nasal cartilage or alar cartilage?", "Does the nasal structure include a section formed by the nasal bone and the frontal process of the maxilla?", "Is there a region where the skin temperature would be expected to be around 32 to 34 degrees Celsius?", "Can you see an area with a rich capillary network supporting both the skin and mucosa?", "Is there a part of the nose likely to have moderate to high nerve density, with sensory input from branches of the trigeminal nerve?", "Does the tissue in this region appear consistent with a water content of about 60 to 70 percent by weight?", "Is there a visible area with minimal subcutaneous adipose tissue, indicating low fat content?", "Can you identify a region where the skin texture is smooth but may have visible pores?", "Is there a part of the nose where the melanin concentration is moderate and reflects the overall facial skin tone?", "Does the tissue in this area appear to have a density similar to other facial soft tissues, around 1.05 grams per cubic centimeter?", "Is there a region where the skin pH is likely slightly acidic, between 4.5 and 5.5?", "Can you see an area of the nose with low hair follicle density, showing few or no terminal hair follicles?"], "relational": ["Does the image show a structure that is part of the respiratory system on the left side of the face?", "Can you identify an area adjacent to the left nasal bone or left maxilla?", "Is there a region supported by the frontal process of the maxilla on the left side?", "Does the image contain cartilaginous features such as the left lateral nasal cartilage or left alar cartilage?", "Can you see an area corresponding to the left nasal vestibule or left inferior meatus?", "Is there a visible structure composed of skin, subcutaneous tissue, cartilage, bone, and mucosa on the left side of the nose?", "Does the image show a region that could receive blood from the facial artery or lateral nasal artery on the left?", "Can you identify an area that might be innervated by the infraorbital nerve or the external nasal branch of the anterior ethmoidal nerve?", "Is there a structure lateral to the nasal septum and separated from it by septal cartilage and mucosa?", "Can you see a region externally connected to the left nostril, left nasolabial fold, or left cheek?"], "contexual_behavior": ["Is there evidence of reduced airflow through a structure that could be affected by mucosal swelling or inflammation?", "Can you identify a region where filtration of inhaled particles might be impaired due to inflammation or ciliary dysfunction?", "Does the image show increased mucus production in response to potential allergen exposure such as pollen or dust mites?", "Is there a structure that might display impaired olfactory function due to inflammation or blockage from a sinus infection?", "Can you see signs of decreased humidification of inspired air, possibly due to mucosal dryness in a dry environment?", "Is there a region that appears less effective at warming air, which could result from cold exposure or decreased blood flow?", "Does the image suggest an altered airflow pattern that might be caused by a deviated septum narrowing a nasal passage?", "Can you identify a structure where mucus drainage appears impaired, possibly due to chronic inflammation or sinus ostia obstruction?", "Is there evidence of enhanced defense mechanisms, such as increased mucus or immune cell activity, in response to a viral infection?", "Does the image show signs of reduced airflow during what could be an episode of sleep apnea, possibly due to airway obstruction?", "Can you see a region that seems to compensate for reduced function on the opposite side, perhaps by increasing airflow or activity?", "Is there evidence of impaired ciliary activity or epithelial damage that could be attributed to exposure to tobacco smoke?", "Does the image suggest increased blood flow in a region, potentially as part of the autonomic regulation during a nasal cycle shift?", "Can you identify a structure where filtering efficiency appears decreased, possibly due to particulate overload in a polluted environment?", "Is there a region showing altered function, such as changes in airflow, filtration, or sensation, that might result from trauma or injury?"], "functions": ["Is there a structure in the image that participates in the passage of air and filtration of inhaled particles?", "Can you identify an area where nasal hairs and mucus might be present to trap dust and microbes?", "Does the image show a region that could add moisture to inhaled air through a mucosal lining?", "Is there evidence of a vascularized mucosa that could warm incoming air via heat exchange?", "Can you see a location where olfactory epithelium might be present for detecting odor molecules?", "Is there a part of the image that could house immune cells or produce antimicrobial secretions for defense?", "Does the image show a region likely involved in mucus production and ciliary clearance toward the pharynx?", "Can you identify an area where mucociliary transport might remove trapped airborne particles?", "Is there a structure that could regulate airflow by adjusting the size of the nasal passage during breathing?", "Does the image contain a region that might contribute to vocal resonance by shaping the nasal cavity and affecting sound quality?"]}, "no_questions": {"contexual_properties": ["Are there areas where the skin seems to be sloughing off, possibly due to necrosis and tissue separation?", "Do you observe signs that might suggest a decrease in blood protein, such as edema or fluid accumulation?", "Is there visible swelling of the skin that could be due to inflammation or fluid shift?"], "properties": ["Can you identify areas where the thickness of necrotic tissue appears to be several millimeters or more?", "Does the image display skin areas with a white, charred, or leathery appearance?", "Is there evidence of marked swelling, either locally or throughout the body?"], "relational": ["Does the image suggest possible compromise of the respiratory or immune systems due to the extent of injury?", "Is there visible involvement of vascular structures, such as damaged capillaries or larger blood vessels?", "Does the image display affected anatomical regions such as the limbs, torso, face, neck, hands, or feet?"], "contexual_behavior": ["Does the image show evidence of compromised barrier function that could allow pathogens to enter the body?", "Does the image suggest reduced oxygen delivery to tissues, such as pallor or signs of hypoperfusion?", "Does the image suggest impaired regulation of body pH, such as signs of metabolic acidosis?"], "functions": ["Can you identify features that might be associated with systemic inflammation or a systemic inflammatory response?", "Can you see features that would increase nutrient requirements or indicate altered nutrient utilization, such as widespread tissue catabolism?", "Is there evidence of a hypermetabolic state, such as extensive tissue damage that would increase energy and protein requirements?"]}}, "right side was not patent?": {"yes_questions": {"contexual_properties": ["Does the image show evidence of reduced blood flow on one side, possibly due to vascular occlusion or stenosis?", "Is there a region that appears obstructed, suggesting thrombosis, embolism, or congenital atresia?", "Can you identify signs of increased pressure on one side, such as might occur in right-sided heart failure or pulmonary hypertension?", "Is there visible swelling or edema localized to one side, which could indicate lymphatic obstruction or inflammation?", "Does the image reveal abnormal tissue formation, such as masses or nodules, that could represent tumors, fibrosis, or granulomatous disease on one side?", "Is there structural narrowing or irregularity on one side, possibly due to atherosclerosis, scarring, or congenital malformation?", "Can you observe discoloration\u2014such as cyanosis, bruising, or pallor\u2014on one side, suggesting poor perfusion or hypoperfusion?", "Is there evidence of fluid accumulation, like pleural effusion, ascites, or localized edema, affecting one side?", "Does one side appear to have decreased oxygenation, as might be seen with hypoxemia, pulmonary embolism, or impaired ventilation?", "Is there a loss of flexibility or increased stiffness on one side, which could be due to fibrosis, sclerosis, or chronic inflammation?", "Can you see thickening of the walls or hypertrophy on one side, possibly resulting from chronic pressure overload or inflammation?", "Is there an abnormal mass, cyst, or abscess present on one side?", "Does the image suggest altered flow rates or patterns on one side, as might occur with stenosis, occlusion, or shunt formation?", "Is there pallor or paleness on one side, which could be due to anemia, arterial insufficiency, or recent blood loss?", "Can you identify signs of increased vascular resistance on one side, such as might be seen in vascular disease, vasospasm, or chronic hypertension?"], "properties": ["Does the image show any anatomical structures on the right half of the body, such as the right lung, right kidney, or right atrium?", "Is there evidence of normal organ-specific size or anatomical variation in structures located on the right side?", "Can you observe bilateral symmetry between the right and left sides in terms of organ shape and contours?", "Does the color of the right-sided organs or tissues in the image match the expected hues, such as flesh-toned skin or reddish-brown liver tissue?", "Are the tissue types present on the right side consistent with epithelial, muscle, connective, or nervous tissues?", "Can you estimate the proportion or weight of right-sided organs compared to the rest of the body based on the image?", "Is there visual evidence of normal venous blood flow to the right atrium or pulmonary circulation through the right lung?", "Can you infer differences in oxygen saturation between venous and arterial blood in right-sided structures?", "Does the image suggest typical pressure levels in right-sided anatomical sites, such as lower pressure in the right atrium?", "Is there any indication that the temperature of right-sided tissues is consistent with core body temperature?", "Can you assess whether the water content or tissue hydration on the right side appears normal and similar to the left?", "Are cell types such as epithelial cells, myocytes, or neurons identifiable in right-sided structures?", "Does the density of tissues or organs on the right side appear comparable to the left, considering bone, muscle, fat, and organ composition?", "Is there any visual clue that the acid-base balance or blood pH in right-sided tissues is within the normal range?"], "relational": ["Does the image show a portion of a paired anatomical structure that is not open or unobstructed on one side?", "Is there evidence that the right component of a bilateral organ or system is not patent?", "Can you identify any differences between the two sides of a paired structure, specifically regarding the openness of the right side?", "Does the image suggest that the right portion of the cardiovascular, respiratory, or lymphatic system is not allowing normal flow?", "Is there a visible obstruction or closure in the area corresponding to the right thoracic cavity?", "Can you see any abnormality in the right upper quadrant or right limb that could indicate lack of patency?", "Does the right side of a structure, such as a vessel or duct, appear different from the left in terms of openness?", "Is there a region adjacent to the midline where the right side appears compromised compared to the contralateral side?", "Are there any unique vascular structures on the right that appear blocked or absent?", "Does the image show a right-sided anatomical landmark that is not continuous or open as expected?", "Can you observe any interaction between the right side and neighboring organs, such as the diaphragm or liver, that suggests a lack of patency?", "Is there a difference in the appearance of the right and left lobes or segments of an organ that could indicate the right side is not patent?"], "contexual_behavior": ["Does the image show evidence of a vessel or lumen on the right side that appears obstructed or narrowed?", "Is there a region on the right side where blood flow seems restricted, potentially leading to reduced oxygen delivery to tissues?", "Can you identify signs of increased pressure upstream or decreased perfusion downstream of a right-sided blockage?", "Does the image suggest hypoperfusion or possible organ dysfunction on the right side due to impaired blood flow?", "Are there visual indications of metabolic waste accumulation, such as edema, on the right side that could result from blocked venous or lymphatic drainage?", "Is there evidence of collateral vessel formation or vascular remodeling on the right side, suggesting the body is compensating for an obstruction?", "Can you see any signs of tissue ischemia or hypoxia on the right side that might result from insufficient blood supply?", "Does the image suggest impaired nutrient transport or possible malnutrition in tissues on the right side due to reduced blood flow?", "Are there features indicating disrupted venous return, such as venous stasis or congestion, on the right side?", "Is there evidence that blood distribution on the right side is altered during physical activity, possibly leading to reduced oxygen delivery or exercise intolerance?"], "functions": ["Does the image show evidence of impaired flow or obstruction on one side, such as congestion or reduced physiological function?", "Can you identify signs of disrupted circulation, such as tissue hypoxia or congestion, specifically affecting the right side?", "Is there visual evidence of pressure buildup upstream or reduced perfusion downstream, suggesting impaired circulation on the right?", "Does the image reveal organ dysfunction or signs of reduced substrate delivery and waste accumulation on one side?", "Can you see indications of collateral vessel formation or increased pressure in alternative pathways, possibly compensating for a blockage?", "Is there evidence of decreased oxygen or nutrient delivery to tissues on the right, such as cellular injury or metabolic disturbances?", "Does the image suggest a disruption of normal flow or physiological exchange, leading to impaired function on one side?", "Are there visible clinical signs such as swelling, cyanosis, or dysfunction that could result from impaired flow on the right?", "Can you observe features indicating hemodynamic disruption, pressure imbalance, or failure of tissue homeostasis on one side?", "Is there evidence of impaired waste removal or toxin accumulation, such as tissue changes or metabolic disturbance, on the right?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a visible area that could contain necrotic tissue, cellular debris, or inflammatory cells such as neutrophils or macrophages?", "Can you see a well-demarcated border separating two regions, possibly with an adjacent zone of inflammation?", "Can you identify an area that is pale, white, or dark red, possibly indicating different types of tissue injury?"], "relational": ["Is there visual evidence of a process such as ischemia, thrombosis, or embolism affecting the tissue?", "Does the image display changes in the cerebral cortex, myocardial wall, renal cortex, or pulmonary lobes that suggest localized damage?", "Are there regions containing cells such as neutrophils or macrophages, possibly indicating an inflammatory response?"], "contexual_behavior": [], "functions": ["Can you identify an area in cardiac tissue where electrical conduction or contractility might be impaired?", "Is there evidence of localized cell death due to a prolonged lack of oxygen and nutrients?", "Can you see signs of compromised cellular metabolism, such as regions that might be experiencing hypoxia?"]}}, "hemisection of nose left": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling on one side of the nasal structure that could suggest edema or inflammation?", "Can you observe any color changes such as bruising, redness, or bluish discoloration on the left portion of the nose?", "Is there any abnormal tissue growth, such as a mass or nodule, visible on one half of the nose that could indicate neoplasia or granulomatous disease?", "Does the image show signs of inflammation, such as redness or swelling, affecting one side of the nasal region?", "Is there increased vascularity or visible blood vessels on one half of the nose, possibly indicating chronic inflammation or neoplastic changes?", "Can you identify any edematous appearance on the left side of the nose that might result from trauma or allergic reactions?", "Is there any visible tissue loss, ulceration, or necrotic area on one side of the nose?", "Can you see any ulcerated lesions or open sores on the left nasal region that might be due to infection or autoimmune disease?", "Is there discoloration such as bruising, cyanosis, or erythema present on one half of the nose?", "Does the image reveal any structural deformity, such as flattening or irregular contour, on one side of the nose that could be due to trauma or cartilage loss?", "Is there any abnormal secretion, such as purulent discharge or excessive mucus, coming from one side of the nose?", "Can you observe thickening of the tissue on the left nasal region, which might suggest chronic inflammation or fibrosis?", "Are there changes in mucosal texture, such as atrophy or hypertrophy, visible on one half of the nose?", "Is there visible crusting or dryness affecting one side of the nasal structure?", "Does one half of the nose appear unusually pale, which could indicate anemia or vasoconstriction?", "Is there evidence of increased bleeding or blood staining on one side of the nose, possibly related to trauma or vascular lesions?", "Can you identify any necrotic areas or tissue breakdown on the left nasal region?", "Is there granulation tissue or signs of healing present on one half of the nose following injury or surgery?", "Does the image show loss of cartilage integrity or collapse of the nasal structure on one side?", "Is there evidence of atrophy or thinning of the tissue on one half of the nose, possibly due to chronic inflammation or previous surgery?"], "properties": ["Does the image show a structure that represents approximately half of the external nasal anatomy, measuring around 2\u20133 cm in width and 3\u20134 cm in height?", "Can you identify an asymmetrical, convex structure that appears as a vertical bisected portion of the nose?", "Is there an object present that would be expected to weigh between 10 and 15 grams?", "Does the image contain a structure that is skin-colored externally and pink to reddish internally due to mucosal lining and vascularity?", "Can you see a region composed of skin, subcutaneous tissue, cartilage, bone, mucosa, and connective tissue?", "Is there evidence of cell types such as keratinocytes, chondrocytes, fibroblasts, endothelial cells, or respiratory epithelial cells within a nasal structure?", "Does the thickness of the visible nasal portion vary from 2 to 5 mm, with thicker areas near the septum and thinner at the alar region?", "Can you identify a structure with a surface area of approximately 10\u201315 square centimeters, representing half of the external nose?", "Is there an object whose soft tissue composition would suggest a water content of about 60\u201370% by weight?", "Does the density of the visible nasal structure appear consistent with soft tissue, around 1.05 grams per cubic centimeter?", "Is there evidence of high vascularity, such as a rich capillary network supporting both skin and mucosal surfaces, in the nasal region?", "Can you see significant cartilage content, including lateral nasal cartilage, alar cartilage, and part of the septal cartilage, in the left half of the nose?", "Is there a region where the density of epithelial cells appears high, especially in the respiratory mucosa, with an estimated 1\u20132 million cells per square centimeter?", "Does the visible nasal structure appear to maintain a temperature close to core body temperature, around 36\u201337\u00b0C?", "Is there an indication that the mucosal surface of the nasal region has a slightly acidic pH, ranging from 5.5 to 6.5?"], "relational": ["Does the image display a subdivision of the external nose and nasal cavity on one side?", "Can you identify regions such as the left nasal vestibule or the left nasal cavity proper?", "Is there a visible lateral nasal wall on the left side?", "Does the image show bones like the left nasal bone or the left maxilla?", "Can you see the frontal process associated with the left side of the nose?", "Are there cartilaginous structures such as the left lateral nasal cartilage or left alar cartilage present?", "Is the septal cartilage visible on the left side?", "Does the image reveal tissues like respiratory epithelium or connective tissue within the nasal region?", "Can you identify blood vessels or nerves within the left nasal structures?", "Are the nasal septum medially and the lateral nasal wall laterally visible in relation to each other?", "Is the nasal floor seen inferior to the nasal cavity on the left?", "Does the image contain structures that are part of the respiratory system?", "Are anatomical features such as nasal conchae or meatuses exposed on the left side?", "Can you see the underlying nasal mucosa on the left?", "Is the relationship between the left side of the nasal septum and the lateral nasal wall apparent?", "Are adjacent facial structures like the left maxillary sinus, left orbit, or left upper lip visible near the nasal region?"], "contexual_behavior": ["Does the image show evidence of disrupted airflow through the left nasal passage?", "Is there a visible structural discontinuity affecting the left nasal airway?", "Can you identify features that might indicate reduced olfactory function on the left side?", "Does the image suggest damage to the left olfactory epithelium or its neural pathways?", "Are there signs of altered mucociliary clearance in the left nasal cavity, such as loss of ciliated cells or mucosal lining?", "Does the left side of the nasal cavity appear to have reduced mucosal surface area, potentially affecting humidification and warming of inspired air?", "Is there evidence that the left nasal mucosal barrier is compromised, possibly increasing susceptibility to pathogen entry?", "Can you see any obstruction or disruption that might impair drainage of the left paranasal sinuses?", "Does the image suggest changes in the volume or patency of the left nasal cavity that could affect the resonance of voice during speech?", "Are there indications that filtration of particulates on the left side is reduced, such as loss of mucosal or vibrissae structures?", "Does the left nasal region show signs of submucosal blood vessel disruption that could alter vascular response to temperature changes?", "Is there visual evidence of impaired healing or reduced regenerative tissue in the left nasal area, possibly due to compromised vascular supply?"], "functions": ["Does the image show a structure that allows air to pass through and be conditioned before reaching the lower airways?", "Can you identify a region responsible for filtering inhaled air using mucosa and hair to trap particulates?", "Is there a visible area where mucous membranes might add moisture to inhaled air?", "Does the image contain a structure with a rich vascular supply that could warm inspired air through heat exchange?", "Can you see a region that could house sensory cells for detecting odors?", "Is there evidence of tissue that might contain immune cells or produce antimicrobial secretions for mucosal immunity?", "Does the image show a surface likely to produce mucus and facilitate its clearance via ciliary movement?", "Can you identify a part of the nasal cavity that would contribute to the resonance and modulation of the voice?", "Is there a structure present that plays a role in protecting the respiratory tract by conditioning inhaled air?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see a mass surrounded by a fibrous capsule or adjacent parenchyma?", "Can you identify a lesion with a defined capsule, infiltration margin, or interface with adjacent tissue?", "Is there a mass supported by fibrous stroma, blood vessels, or connective tissue visible in the image?"], "contexual_behavior": [], "functions": ["Does the image contain a mass that could be inducing new blood vessel formation or compressing existing vessels?", "Is there evidence of altered cell proliferation or impaired cell death in any visible structure?", "Is there a structure that appears to be altering the extracellular matrix or impairing normal tissue repair?"]}}, "patency side": {"yes_questions": {"contexual_properties": ["Does the image show a vessel segment that appears narrowed, as might occur in stenosis or atherosclerosis?", "Can you identify a region where the vessel is obstructed, possibly due to a thrombus, embolus, or external compression?", "Is there evidence of vessel dilation or widening, such as might be seen in aneurysm formation?", "Does the image reveal an area of reduced blood flow, which could result from partial blockage, vasospasm, or increased resistance?", "Can you see vessel walls that appear irregular, suggesting arteriosclerosis or prior vascular injury?", "Is there a segment of the vessel that looks less flexible, potentially due to fibrosis, calcification, or chronic inflammation?", "Does the vessel show signs of increased resistance, such as narrowing, turbulence, or wall thickening?", "Is there a vessel segment that appears compressed by an external mass, tumor, or edema?", "Can you identify abnormal tissue growth along the vessel wall, such as neoplasia, intimal hyperplasia, or plaque formation?", "Does the vessel show changes in diameter that could indicate vasoconstriction, vasodilation, or remodeling?", "Is there evidence of structural defects in the vessel, possibly due to congenital malformation, trauma, or degenerative changes?", "Can you see a dilated vessel segment that might be responding to increased pressure or wall weakness?", "Does the vessel wall appear thickened, as might occur in chronic hypertension, atherosclerosis, or inflammation?", "Is there a partially blocked vessel segment, possibly due to atheromatous plaque, thrombus, or external compression?", "Can you observe changes in the vessel's surface texture, such as those caused by endothelial damage, ulceration, or fibrosis?"], "properties": ["Does the image show a structure with a diameter between 1 and 10 millimeters, typical of a vessel or duct?", "Can you identify a tubular or cylindrical structure that would allow for unobstructed flow?", "Is there an anatomical feature whose length spans several centimeters depending on its location?", "Does the image contain a structure where the surface area could be estimated from its length and diameter?", "Can you see a wall thickness in a vessel-like structure that ranges from 0.1 to 2 millimeters?", "Is there a region that appears pale pink to white, suggesting healthy tissue?", "Does the image show a smooth surface that would facilitate laminar flow?", "Can you identify a structure composed of layers such as endothelium, smooth muscle, and connective tissue?", "Is there evidence of elasticity in a structure, allowing it to expand and contract with pressure changes?", "Does the image show a wall that appears strong enough to withstand normal internal pressures without rupturing?", "Can you see a lumen whose size would ensure adequate passage for fluids or cells?", "Is there a structure where the internal pressure would likely fall within physiological ranges, such as 10\u2013120 mmHg for blood vessels?", "Does the image suggest a flow capacity determined by cross-sectional area and pressure gradient, supporting normal physiological flow?", "Can you identify cellular layers that might include endothelial cells, smooth muscle cells, or fibroblasts?", "Is there a structure whose temperature would be expected to match core body temperature, around 36.5\u201337.5\u00b0C?"], "relational": ["Does the image show a feature present in tubular structures such as blood vessels or ducts?", "Can you identify a region that is part of the cardiovascular, lymphatic, or exocrine system?", "Is there a surface adjacent to the vessel wall or surrounded by connective tissue?", "Does the image contain an area located within vascular regions, ductal pathways, or tubular organs?", "Can you see a feature associated with arteries, veins, bile ducts, or ureters?", "Is there a surface in contact with endothelium, epithelial lining, or smooth muscle?", "Can you identify an interface between the vessel wall and an open channel?", "Does the image show a boundary defined by the inner surface of a vessel or duct?", "Is there a region contiguous with the lumen or bordering the lumen of a tubular structure?", "Can you distinguish a surface that is different from the abluminal side or external wall?", "Is there an area where blood, lymph, secreted fluids, or cellular elements might interact with the inner surface?"], "contexual_behavior": ["Does the image show a vessel with reduced flow that could be due to narrowing from plaque buildup or stenosis?", "Is there evidence of a vessel that appears obstructed, possibly by a blood clot, indicating loss of openness?", "Can you identify a vessel that seems widened, suggesting increased openness after smooth muscle relaxation or vasodilation?", "Does the image reveal a vessel with narrowing and swelling that might be caused by inflammation or edema?", "Is there a vessel that appears significantly obstructed by plaque, consistent with atherosclerosis?", "Can you see a vessel with a stent in place, indicating mechanical support and restored openness?", "Is there a vessel showing signs of injury, swelling, or hematoma that could result from trauma?", "Does the image display a vessel that appears compressed by surrounding tissues, possibly leading to impaired flow?", "Can you identify a vessel where normal flow seems restored after removal or dissolution of a clot?", "Is there evidence of a vessel with a reduced lumen diameter, possibly due to chronic vascular disease or vessel remodeling?", "Does the image show a vessel with insufficient filling or reduced flow that might be related to hypovolemic shock?", "Can you see a vessel that appears more open following a surgical procedure such as angioplasty or bypass?", "Is there a vessel that looks less filled or narrowed, potentially due to severe dehydration and low plasma volume?", "Does the image reveal a vessel with sudden narrowing, suggesting increased resistance from vasospasm?", "Is there a vessel where inadequate perfusion might be present, possibly due to low cardiac output as seen in heart failure?"], "functions": ["Does the image show a region within a vessel where the lumen appears unobstructed, allowing for physiological flow?", "Can you identify an area that provides a clear pathway for uninterrupted blood circulation?", "Is there evidence of a vessel segment that resists occlusion, such as the absence of thrombus or restenosis?", "Does the image display a portion of a vessel that supports continuous blood delivery to downstream tissues?", "Can you see features suggesting maintenance of lumen integrity, such as a smooth endothelial lining or lack of neointimal thickening?", "Is there a region that appears to have recovered normal circulation following an intervention, indicated by restored vessel openness?", "Does the image contain a vessel segment that would allow for effective oxygen and nutrient transport due to its open conduit?", "Can you identify an area that may prevent thrombosis by maintaining a non-thrombogenic surface and promoting laminar blood flow?", "Is there visual evidence of vascular healing or remodeling, such as endothelialization or adaptive changes in vessel structure?", "Does the image suggest a vessel segment with favorable long-term openness, potentially indicating a positive endovascular procedure outcome?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see a structure that has either a single cervix or partially separated cervices?", "Can you identify a structure with a prominent external indentation at its uppermost part?", "Does the image show a structure that is part of the female reproductive system?"], "contexual_behavior": [], "functions": ["Can you see an organ that supports gestation by providing a nurturing environment for embryo implantation and fetal growth, but with a divided cavity that may affect gestational capacity?", "Can you identify a structure where endometrial shedding involves the loss of lining from two separate uterine cavities during menstruation?", "Is there a structure that contracts during labor to expel the fetus, where its abnormal shape could increase the risk of malpresentation or preterm birth?"]}}, "left side": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling on one side that could suggest localized infection, trauma, or lymphedema?", "Can you observe any discoloration that might indicate bruising, vascular compromise, or inflammation on one half of the body?", "Does one side appear larger than the other, possibly due to edema, tumor growth, or unilateral hypertrophy?", "Is there visible volume loss or wasting on one side that could be caused by muscle atrophy, tissue wasting, or nerve injury?", "Can you detect abnormal texture, such as fibrosis or scarring, on one side compared to the other?", "Is there an area that appears tender or firm, possibly related to infection, inflammation, or neoplastic processes?", "Do you see signs of fluid accumulation, such as localized edema or abscess formation, on a particular side?", "Is there a region with increased temperature that might suggest infection, inflammation, or cellulitis?", "Does one side appear paler than the other, which could be due to anemia, poor perfusion, or arterial occlusion?", "Can you identify bruising on one side that might result from trauma, coagulopathy, or vascular injury?", "Is there evidence of reduced sensation on one side, possibly indicating nerve compression, neuropathy, or stroke?", "Does one side show signs of edema that could be related to lymphatic obstruction, venous insufficiency, or inflammation?", "Can you observe muscle wasting on one side, potentially due to disuse, denervation, or chronic disease?", "Is there an abnormal growth, such as a tumor, cyst, or nodule, present on one side?", "Do you notice changes in tissue composition, like fat redistribution or muscle loss, affecting only one side?", "Is there increased rigidity on one side, possibly due to contracture, fibrosis, or spasticity?", "Does one side show signs of strength loss that could be attributed to nerve injury, muscle atrophy, or stroke?", "Can you detect abnormal movement, such as dystonia, tremor, or hemiparesis, affecting one side?", "Is there increased sensitivity to touch on one side, which might be due to neuropathy, inflammation, or allodynia?", "Do you see skin changes, such as rash, ulceration, or thickening, that are localized to one side?"], "properties": ["Does the image show a region defined by the midsagittal plane dividing the body into two halves?", "Can you identify an area that represents approximately half of the total body surface area?", "Is there a region with a volume estimated to be about 35 to 40 liters in an average adult?", "Does the depicted area appear to have a temperature consistent with core body temperature, around 36.5 to 37.5 degrees Celsius?", "Can you observe a region where the skin color matches the individual's overall pigmentation, influenced by melanin, hemoglobin, and carotene?", "Is there an area composed of skin, subcutaneous fat, muscle, bone, blood vessels, and nerves?", "Can you identify a region where the skin thickness ranges from 1.5 to 2.0 millimeters, depending on anatomical location?", "Does the image show an area likely to have a nerve density of approximately 2,000 to 3,000 nerve endings per square centimeter in glabrous skin?", "Is there a region that would receive about half of the total systemic blood supply, roughly 2.5 to 3 liters at any given time?", "Can you see an area where the muscle mass constitutes about 40 to 50 percent of the total skeletal muscle mass, potentially influenced by handedness and activity?", "Does the depicted region show a fat distribution pattern that mirrors the opposite side, with subcutaneous and visceral fat varying by sex, age, and genetics?", "Is there an area where the bone density is similar to the opposite side, averaging 1.2 to 1.5 g/cm\u00b3 in healthy adults?", "Can you observe a region on the scalp with a hair density of about 60 to 100 follicles per square centimeter, with possible regional variation?", "Does the image show an area where the tissue water content is approximately 60 percent by weight?", "Is there a region that would contain about 1.5 to 2 million sweat glands, representing half of the total body sweat glands?"], "relational": ["Does the image display anatomical regions such as the left thorax or left abdomen?", "Can you identify organs typically found on the left side, such as the spleen or the left kidney?", "Is there a structure that could be the left ventricle or atrium of the heart?", "Does the image show bones like the left humerus or left femur?", "Can you see muscles such as the left deltoid or left quadriceps femoris?", "Is there evidence of bilateral symmetry between left and right anatomical features?", "Does the image reveal blood vessels like the left subclavian artery or left jugular vein?", "Can you identify nerves such as the left brachial plexus or left sciatic nerve?", "Are there visible features representing the musculoskeletal or circulatory systems on one side of the body?", "Does the image include structures unique to one side, such as the aortic arch or spleen?", "Can you see lymphatic structures like the thoracic duct or left axillary lymph nodes?", "Is there a contralateral relationship between paired structures in the image?", "Does the image show the cardiac apex oriented towards one side?", "Are there digestive system components, such as the descending colon or pancreatic tail, visible on one side?", "Can you identify the left gastric artery or left renal vein in the image?"], "contexual_behavior": ["Does the image show any evidence of weakness or paralysis on one side of the body that could suggest contralateral effects from a cerebral event?", "Is there a visible indication of reduced sensation, such as numbness or altered touch response, on one side that might be due to nerve injury?", "Can you observe signs of asymmetric blood flow or swelling that could indicate perfusion deficits related to heart failure?", "Does the image reveal any loss of coordination or abnormal movement patterns on one side that might be associated with neurodegenerative disease?", "Is there a noticeable decrease in muscle bulk or strength on one side that could be attributed to trauma or injury?", "Can you identify delayed wound healing or tissue changes on one side, possibly related to diabetes and impaired microvascular function?", "Does the image show swelling or fluid accumulation on one side that could be consistent with lymphedema or lymphatic obstruction?", "Are there any abnormal reflex responses, such as exaggerated or absent reflexes, on one side that might suggest a spinal cord injury?", "Is there evidence of impaired temperature regulation, such as color or texture changes, on one side that could indicate autonomic dysfunction?", "Can you see limitations in movement or joint mobility on one side that might be a result of recent orthopedic surgery?", "Does the image suggest improvement in strength, coordination, or mobility on one side, possibly due to ongoing physical rehabilitation?", "Are there visual cues of altered sensation, such as numbness or tingling, on one side that could be linked to demyelinating disease?", "Is there a lack of voluntary movement or responsiveness on one side that might indicate paralysis from neurological impairment?", "Can you observe increased muscle tone or spasticity on one side, which could be characteristic of a motor disorder like cerebral palsy?", "Does the image show signs of reduced circulation, such as pallor or thinness, on one side that could be due to peripheral artery disease?"], "functions": ["Does the image show evidence of lateralization, such as structures or functions specific to one half of the body?", "Can you identify features that indicate body symmetry or asymmetry between the two sides?", "Is there a region in the image where organs like the lung, kidney, or atrium are localized on one side?", "Does the image display any structures involved in motor coordination or neuromuscular control specific to one half?", "Can you see anatomical features that would be responsible for proprioception or postural control on a particular side?", "Is there evidence of neural pathways or peripheral nerves serving one half of the body?", "Does the image include structures such as the ventricle or atrium that are involved in pumping oxygenated blood to the body?", "Can you identify thoracic structures that contribute to pulmonary ventilation or respiratory mechanics on one side?", "Is there a visible pathway or vessel, such as the thoracic duct, associated with lymphatic drainage into a subclavian vein?", "Does the image show muscles whose contraction and relaxation would enable movement or force generation on one half of the body?", "Can you observe features that suggest contralateral innervation or sensory processing for one side?", "Is there evidence of organ placement or visceral asymmetry in the image?", "Does the image display any anatomical landmarks that would indicate the presence of the left hemisphere's influence on body function?"]}, "no_questions": {"contexual_properties": ["Is there an indication that weight gain has plateaued, possibly due to illness or inadequate nutrition?", "Is there a visible increase in respiratory rate, which could be a response to respiratory distress or metabolic disorders?", "Does anyone in the image display decreased muscle tone, possibly indicating hypotonia or neuromuscular disorders?"], "properties": ["Can you identify someone with a head circumference likely between 33 and 35 centimeters?", "Does the image show a person whose blood pressure is likely around 60/40 to 80/50 mmHg?", "Does the image show a person with an estimated body fat percentage of about 13 to 15 percent?"], "relational": ["Is there a visible thymus or liver that appears relatively large for the body size?", "Does the image lack any connection to the placenta or umbilical cord, indicating closed umbilical circulation?", "Does the subject display open fontanelles as opposed to a fully fused skull?"], "contexual_behavior": ["Is there a young individual who may have decreased nutrient absorption during illness due to gastrointestinal disturbances?", "Is there evidence of a person in the early stage of life who might be undergoing dietary transition, such as weaning or introduction of solid foods?", "Does the image show a young individual who may have increased susceptibility to infections due to immature immune responses?"], "functions": ["Does the image include an individual whose growth and development are driven by hormonal control and genetic regulation?", "Is there a subject with limited adaptive immune responses and increased susceptibility to infections?", "Is there a subject whose metabolic processes include accelerated protein synthesis and increased fat utilization?"]}}, "left side showing patency": {"yes_questions": {"contexual_properties": ["Is there a structure on the left side that appears narrowed, which could suggest vascular narrowing or stenosis?", "Can you identify any area on the left side that seems obstructed, possibly due to a thrombus or embolus?", "Does the left side show any evidence of increased diameter, as might be seen in aneurysmal dilation or compensatory enlargement?", "Is there a region on the left side with decreased diameter, which could indicate vasospasm or external compression?", "Do you observe irregular vessel walls on the left side that might be associated with vascular injury or plaque formation?", "Is there any abnormal tissue visible on the left side, such as thickening or masses, which could suggest neoplasia or fibrosis?", "Does the left side show signs of reduced blood flow, possibly due to partial obstruction or distal ischemia?", "Can you see dilation on the left side that might be related to chronic hypertension or post-stenotic changes?", "Are there any structural changes on the left side that could be attributed to congenital anomalies, trauma, or chronic disease?", "Is there evidence of compression on the left side from adjacent masses, tumors, or hematomas?", "Do you notice thickened vessel walls on the left side, which could be due to chronic inflammation or vascular remodeling?", "Is there a tortuous appearance of vessels on the left side, as might occur with aging or connective tissue disorders?", "Does the left side show abnormal coloration, such as pallor or discoloration, which could indicate hypoxia or hemorrhage?", "Can you identify any calcification on the left side, possibly resulting from chronic atherosclerosis or metabolic disorders?", "Is there evidence of increased vascular resistance on the left side, such as narrowing or spasm?"], "properties": ["Does the image show a left-sided structure with an open, unobstructed lumen?", "Can you identify a left-sided vessel with a diameter in the range of 2 to 4 mm?", "Is there a left-sided anatomical passage that appears round or tubular and free of blockage?", "Does the left side display a clear lumen with smooth walls and no evidence of obstruction?", "Can you see a left-sided structure that appears pink or red, suggesting healthy perfusion?", "Is there a left-sided vessel with a wall thickness between 0.5 and 1.5 mm?", "Does the image show a left-sided structure with a cross-sectional area between 3 and 12 mm\u00b2?", "Can you identify a left-sided vessel with a smooth and elastic texture?", "Is there evidence of normal physiological flow, such as a flow rate between 50 and 100 mL/min, on the left side?", "Does the left side contain a structure where the pressure appears to be within the normal arterial range of 80 to 120 mmHg?"], "relational": ["Does the image show open blood vessels such as the left subclavian artery or left common carotid artery?", "Is there evidence of unobstructed pulmonary veins on one side of the image?", "Can you identify structures belonging to the cardiovascular, respiratory, or lymphatic systems on the left side?", "Is there a visible left lung or left atrium present in the image?", "Does the image display anatomical features within the left thoracic cavity, left upper limb, or left side of the neck?", "Are there tissues such as vascular endothelium, cardiac muscle, or pulmonary tissue visible on the left side?", "Can you see structures that are adjacent to the heart, trachea, or vertebral column on the left?", "Is the left kidney or left atrium of the heart visible in the image?", "Does the image show anatomical boundaries such as the midline medially and the lateral thoracic wall laterally on one side?", "Are there connections to structures like the aortic arch, left brachiocephalic vein, or left bronchus on the left side?", "Can you identify features consistent with the left hemithorax or left systemic circulation?"], "contexual_behavior": ["Does the image show a region on the left where vessel openness is preserved despite possible vascular obstruction?", "Can you identify an area on the left that appears free from narrowing due to plaque buildup or atherosclerosis?", "Is there evidence on the left side of restored blood flow following an intervention such as angioplasty or thrombolysis?", "Does the left region display vessel openness that could result from clot dissolution or thrombolytic therapy?", "Can you see a left-sided vessel that does not exhibit narrowing or swelling suggestive of inflammation?", "Is there a left-sided structure where arterial flow appears unobstructed, indicating absence of an acute embolic event?", "Does the image suggest that collateral circulation is maintaining vessel openness on the left despite signs of chronic disease?", "Can you observe a left-sided vessel that does not show transient constriction or fluctuation in openness, as might occur during vasospasm?", "Is there visual evidence on the left of improved vessel openness following a surgical bypass procedure?", "Does the left side display vessel patency that is not compromised by low arterial pressure or hypoperfusion?", "Can you identify a left-sided vessel that remains open and uncompromised despite possible trauma or vascular injury?", "Is there a structure on the left where a stent might be maintaining vessel openness?", "Does the left region show adequate vessel openness despite the potential for reduced perfusion from severe hypotension?", "Can you see a left-sided vessel that appears open following mechanical or surgical clot removal?", "Is there a vessel on the left that does not appear narrowed by external mass effect, such as tumor compression?"], "functions": ["Does the image show evidence that vessels or passages on the left side are open and unobstructed?", "Can you identify unimpeded blood flow or circulation through structures located on the left side?", "Is there visual indication of adequate perfusion to tissues supplied by left-sided vessels?", "Does the image suggest continuous physiological flow without blockage on the left side?", "Can you see signs that left-sided organs are receiving proper blood supply and nutrients?", "Is there evidence of efficient oxygen and nutrient transport through open vessels on the left side?", "Does the image show absence of obstruction or ischemia in tissues on the left side?", "Can you determine if cardiovascular circulation remains effective and uninterrupted on the left side of the body?"]}, "no_questions": {"contexual_properties": ["Can you identify areas where protein aggregates are larger, suggesting advanced stages of pathology or persistent misfolding?", "Does the image show deposits that appear more abundant in regions typically affected by neurodegenerative disease progression?", "Do any aggregates show differences in solubility or appearance that could result from chemical or structural changes?"], "properties": [], "relational": ["Does the image reveal alterations in neural, glial, or vascular tissue?", "Can you observe deposits closely associated with neuronal cell bodies, synapses, or axons?", "Is there evidence of involvement of cell types like neurons, astrocytes, microglia, or endothelial cells?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal protein aggregation within neural tissue?", "Can you see signs of homeostatic imbalance, such as altered cellular metabolism or oxidative stress in neural tissue?", "Are there features consistent with disrupted neuronal signaling or synapse loss?"]}}, "not patent": {"yes_questions": {"contexual_properties": ["Is there evidence of a structure whose normal opening or flow is obstructed by swelling, such as from edema or tissue inflammation?", "Can you identify a vessel where blood flow appears blocked, possibly due to a clot or thrombus formation?", "Does the image show a duct that appears narrowed or blocked, potentially as a result of inflammation or stenosis?", "Is there a lumen that seems collapsed, scarred, or blocked following trauma or injury?", "Can you see a passage that appears obstructed by a mass, suggesting tumor growth or compression?", "Is there an airway that looks narrowed or blocked, possibly due to mucosal swelling or bronchoconstriction from an allergic reaction?", "Does the image reveal a tube that appears closed or narrowed by fibrotic tissue, indicating stricture or occlusion?", "Can you observe a channel that seems compressed by an adjacent mass or structure, leading to impaired flow?", "Is there a vessel that appears surgically closed, such as after ligation or cauterization?", "Does the image show a structure lacking a normal opening, possibly due to congenital malformation or atresia?", "Can you identify a lumen that appears blocked by swelling, pus, or tissue damage, suggesting infection or abscess formation?", "Is there a passage that seems narrowed or blocked by plaque accumulation, indicating atherosclerotic occlusion?", "Does the image show a duct that appears progressively obstructed, possibly due to chronic disease with ongoing fibrosis or inflammation?", "Can you see a channel that is physically blocked by a foreign object?", "Is there a vessel where blood flow is completely interrupted by a clot, consistent with thrombosis?"], "properties": [], "relational": ["Does the image show a blood vessel, duct, or tube that appears obstructed or closed?", "Can you identify a region where the cardiovascular, respiratory, digestive, or urinary system might be affected by a blockage?", "Is there evidence of an organ such as the heart, lungs, kidneys, liver, or intestines containing a segment that is not open to flow?", "Does the image reveal tissues like endothelium, epithelium, or smooth muscle that appear altered due to a lack of patency?", "Can you see any anatomical structure with signs of impaired flow, increased pressure, or tissue damage adjacent to it?", "Is there a vessel\u2014such as an artery, vein, capillary, or lymphatic channel\u2014that appears to be blocked?", "Does the image include regions like the coronary arteries, biliary tract, bronchi, or urethra that might be compromised by a lack of openness?", "Can you identify a disruption in blood flow, bile drainage, air passage, or urine flow within the depicted structures?", "Is there a visible impact on the circulatory, respiratory, gastrointestinal, or renal system due to a non-patent component?", "Does the image show the presence of thrombi, plaques, calculi, or scar tissue within a tubular or vascular structure?"], "contexual_behavior": ["Does the image show a vessel with a clot that completely blocks its lumen, preventing blood flow?", "Is there evidence of airway narrowing or mucus plugging that could obstruct the airway lumen and impair function, as seen in asthma?", "Can you identify a gastrointestinal segment where the lumen appears obstructed or severely narrowed, potentially delaying transit?", "Is there an artery that appears completely or critically blocked, possibly reducing blood flow after injury?", "Does the image reveal a ureter with a blockage that could prevent urine from passing from the kidneys to the bladder?", "Is there a cerebrospinal fluid pathway, such as the cerebral aqueduct or foramina, that appears blocked and could impair CSF circulation?", "Can you see signs of airway swelling or closure that might prevent effective ventilation and reduce oxygen delivery, as in anaphylaxis?", "Is there a lymphatic vessel that appears obstructed or fibrosed, potentially compromising lymphatic drainage and leading to lymphedema?", "Does the image show a vein with a clot that blocks venous flow, possibly reducing venous return to the heart?", "Is there a bile duct that appears obstructed by a stone, which could prevent normal bile flow?", "Can you identify a segment of intestine that appears twisted or occluded, potentially impairing nutrient absorption as in volvulus?", "Is there a heart valve that appears restricted or closed, which could impede blood flow and decrease cardiac output in a congenital defect?", "Does the image show a cerebral artery that is blocked, possibly reducing perfusion to brain tissue as seen in stroke?", "Is there evidence that the ductus arteriosus is closed after birth in a context where shunting is required for fetal circulation, potentially leading to inadequate oxygenation?", "Can you see a trachea that is blocked by a foreign body, which could prevent air movement to the lungs and result in ventilatory failure?"], "functions": ["Does the image show any anatomical structure where the normal passage of fluids or gases appears to be obstructed?", "Is there evidence of impaired flow or blockage within any vessel or duct in the image?", "Can you identify a region where blood flow seems to be impeded, possibly resulting in tissue ischemia or infarction?", "Does the image suggest an airway that is blocked or restricted, potentially causing respiratory distress or hypoxia?", "Is there a structure that appears to prevent essential substances from reaching or leaving an organ, leading to signs of organ dysfunction?", "Can you observe any duct that seems to inhibit secretion or drainage, resulting in fluid accumulation or possible inflammation?", "Is there visual evidence of tissue damage, inflammation, infection, or loss of function that could be due to a blocked anatomical pathway?", "Does the image reveal signs of disease progression, such as chronic tissue injury or increased risk of infection, associated with stasis or obstruction?", "Are there indications of compensatory mechanisms, such as collateral circulation or alternative drainage pathways, in response to an obstructed structure?", "Can you see any region where accumulation or deprivation of fluids or gases suggests impaired transport due to a physical barrier?"]}, "no_questions": {"contexual_properties": ["Does the section show decreased staining intensity that could result from tissue degeneration or poor fixation?", "Can you observe reduced epithelial height that may suggest atrophy or chronic injury?", "Is there a thickened basement membrane present, possibly indicating chronic inflammation or fibrosis?"], "properties": ["Is there a visible mucosal layer that appears to have been prepared for microscopic examination?", "Does the image show a tissue layer that could be identified by a specific staining technique?", "Can you identify an area where the contrast between different cell types is enhanced, possibly due to a histological stain?"], "relational": ["Does the image show a boundary where the mucosa lies superficial to the submucosa, separated by a thin muscular layer?", "Can you identify epithelial types such as simple columnar, stratified squamous, or pseudostratified epithelium?", "Can you identify a region that could belong to the digestive, respiratory, or genitourinary system?"], "contexual_behavior": ["Are there widened intercellular spaces or loss of tight junctions visible, indicating increased permeability as seen in inflammatory bowel disease?", "Are there indications of increased mitotic figures or abnormal epithelial architecture that would suggest altered epithelial regeneration after injury?", "Can you observe accumulation of immune cells like eosinophils, lymphocytes, or mast cells, which might indicate an allergic reaction?"], "functions": ["Is there evidence of polysaccharide-rich regions, such as mucins or glycogen, highlighted by specific staining techniques?", "Can you observe features that might indicate pathological changes in the mucosal tissue, such as altered architecture or abnormal cellularity?", "Can you identify goblet cells or assess secretory activity based on the staining patterns present in the mucosal layer?"]}}, "choanal patency": {"yes_questions": {"contexual_properties": ["Does the image show evidence of reduced airflow through the posterior nasal passages, possibly due to mucosal swelling or partial blockage?", "Is there a complete obstruction of the posterior nasal airway, as might be seen in cases of bilateral atresia or severe blockage by a foreign object?", "Can you identify signs that suggest improvement in nasal passage openness, such as reduced inflammation or removal of an obstruction?", "Does the image indicate fluctuating openness of the nasal passages, consistent with intermittent congestion or variable inflammation?", "Is there visible swelling of the nasal mucosa or increased secretions that could lead to narrowing of the posterior nasal airway?", "Can you see features suggestive of infection, such as inflammation or increased mucus, that might cause narrowing or blockage of the posterior nasal passages?", "Is there evidence of compromised nasal airway in a newborn, possibly due to congenital blockage or significant obstruction?", "Does the image suggest increased openness of the posterior nasal airway following use of decongestants, anti-inflammatory therapy, or surgical intervention?", "Are there signs of trauma, such as swelling, hematoma, or structural damage, that could alter the openness of the posterior nasal airway?", "Can you identify restriction of the posterior nasal airway due to swelling from allergy, infection, or trauma?", "Is there evidence of mucosal edema and increased secretions from an allergic reaction narrowing the posterior nasal airway?", "Does the image show narrowing of the posterior nasal airway due to congenital anomalies such as atresia or stenosis?", "Can you see signs of surgical correction or removal of an obstruction that would improve the openness of the posterior nasal airway?", "Is there a mass or growth encroaching on the posterior nasal airway, suggesting possible obstruction by a tumor?", "Does the image indicate decreased openness of the posterior nasal airway during nasal congestion caused by inflammation, infection, or allergic response?"], "properties": ["Is there an opening in the image with a diameter appropriate for a neonate or adult, measuring between 3 to 10 millimeters depending on age?", "Can you identify an oval or round anatomical opening in the posterior nasal region?", "Does the image show a passageway with a cross-sectional area greater than 0.4 square centimeters in an adult?", "Is there evidence of mucosal tissue with a thickness between 1 and 2 millimeters lining the nasal passage?", "Does the structure in question appear to allow for low resistance airflow, suggesting unobstructed nasal breathing?", "Can you observe a channel in the nasal region with a length of approximately 10 to 15 millimeters?", "Is there mucosa visible that appears pink and moist within the nasal passage?", "Does the distance between the posterior nasal septum and the edge of the opening measure approximately 2 to 4 millimeters?", "Is there any indication that the pressure gradient across the nasal passage during quiet respiration is less than 1 cm H2O?", "Can you identify a lining composed of pseudostratified ciliated columnar epithelium within the nasal opening?"], "relational": ["Does the image show an open passage at the back of the nasal cavity without visible obstructions?", "Can you identify the region where the nasal cavity connects directly to the nasopharynx?", "Is there evidence of unobstructed airflow from the nasal cavity into the upper respiratory tract?", "Are the posterior nasal apertures free from blockages such as polyps or septal deviation?", "Can you see anatomical boundaries formed by the vomer, palatine bone, or medial pterygoid plates?", "Is the area adjacent to the nasopharynx, soft palate, or Eustachian tube openings clearly visible and unobstructed?", "Does the image show normal communication between the nasal cavity and the nasopharynx?", "Are there any signs of developmental structures, such as remnants of the oronasal membrane, that could affect the openness of the posterior nasal passages?", "Is there any indication of choanal atresia or other abnormalities that might disrupt airflow through the posterior nasal cavity?", "Can you observe features that would support normal function of the respiratory and olfactory systems in this region?"], "contexual_behavior": ["Does the image show evidence of inflammation or swelling of the nasal mucosa that could reduce airflow through the posterior nasal airway?", "Is there visual indication of mucosal edema or congestion that might be associated with an allergic reaction?", "Can you identify signs of reduced swelling in the nasal region that could result from decongestant use or vasoconstriction?", "Is there a structural blockage at the posterior nasal cavity suggestive of a congenital condition present in a neonate?", "Does the image display features consistent with increased mucus production or inflammation, as might occur during an upper respiratory infection?", "Are there visible nasal polyps that could physically obstruct the posterior nasal airway?", "Can you see evidence of recent surgical intervention aimed at removing obstructions or correcting anatomical defects in the nasal passage?", "Is there swelling, bleeding, or structural damage in the nasal area that could result from trauma or injury?", "Does the image suggest increased nasal congestion that might be influenced by the individual's body position, such as lying down?", "Are there signs of extensive mucosal inflammation or edema in the nasal or sinus regions, as seen in severe sinusitis?", "Can you observe reduced tissue swelling or restored airflow in the nasal passage, possibly indicating resolution of previous edema?", "Is there a mass or abnormal growth in the nasal cavity that could be encroaching on the choanal opening?", "Are there features of chronic inflammation or tissue remodeling in the nasal mucosa that might be associated with an autoimmune disease?", "Does the image show reduced mucosal inflammation or edema that could be attributed to corticosteroid therapy?", "Are there signs of mucosal swelling or congestion in the nasal passages that might be triggered by exposure to environmental irritants?"], "functions": ["Does the image show evidence of unobstructed airflow from the nasal cavity to the nasopharynx, supporting effective respiration?", "Can you identify continuous and efficient airflow through the nasal passages, indicating reduced resistance and normal breathing?", "Is there a visible pathway that would allow odorant molecules to reach the olfactory epithelium, supporting the sense of smell?", "Does the image suggest that inhaled air can pass through the nasal mucosa for humidification and filtration before reaching the lower airways?", "Can you see anatomical features that would permit resonance and airflow during speech, contributing to normal vocalization and articulation?", "Is there evidence that the respiratory and digestive tracts are properly separated during swallowing, reducing the risk of aspiration?", "Does the image indicate the ability to maintain equalized pressure between the nasal cavity and nasopharynx, supporting normal middle ear and sinus function?", "Can you observe features that would facilitate drainage and clearance of nasal secretions into the nasopharynx, preventing accumulation?", "Is there an unobstructed nasal airway that would allow for normal breathing during sleep, reducing the risk of sleep-disordered breathing?", "Does the image show a nasal airway that would support proper growth and development of facial and cranial structures in a pediatric patient?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image contain an object connected to blood vessels such as the renal artery or renal vein?", "Can you identify an organ located in the retroperitoneal space of the abdominal cavity?", "Can you see a structure linked to ducts or tubes like the ureters?"], "contexual_behavior": [], "functions": []}}, "hemisection of nose left side": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling on the left side of the nasal structure that could indicate edema or inflammation?", "Can you observe any color changes, such as redness or bruising, on the left portion of the nose that might suggest erythema or ecchymosis?", "Does the image show signs of increased bleeding or blood accumulation on the left nasal area, possibly due to trauma or surgery?", "Is there any indication of abnormal tissue growth, such as granulation tissue or a mass, on the left side of the nose?", "Can you see features consistent with inflammation, such as redness or swelling, on the left nasal region?", "Is there visible tissue loss or ulceration on the left side of the nose?", "Does the left nasal area appear necrotic or show signs of compromised blood supply, such as pallor or tissue breakdown?", "Can you identify any scarring or fibrotic changes on the left nasal region that might have resulted from previous injury or surgery?", "Is there evidence of increased mucus or exudate on the left side of the nose, suggesting irritation or infection?", "Does the image show ulceration or open sores on the left nasal surface?", "Can you observe changes in texture, such as thickening or hardening, on the left side of the nose?", "Is there visible crusting or dried exudate on the left nasal area, possibly indicating healing or recent bleeding?", "Does the left side of the nose show increased vascularity, such as prominent blood vessels or redness, which could be related to healing or inflammation?", "Is there an area on the left nasal region that appears unusually pale, suggesting reduced blood flow or vasoconstriction?", "Can you see swelling or puffiness on the left nasal side that might be due to recent trauma or surgery?", "Is there evidence of tissue regeneration or new epithelial growth on the left side of the nose, indicating healing?", "Does the left nasal region appear atrophic or thinned, possibly due to chronic scarring or ischemia?", "Can you identify granulation tissue on the left nasal area as part of the healing process?", "Is there any indication of abnormal cell proliferation, such as thickening or irregular growth, on the left side of the nose?", "Does the left nasal region appear thickened or hypertrophic, possibly due to chronic inflammation or fibrosis?"], "properties": ["Is there a structure in the image that measures approximately half the total nasal length and width, with dimensions around 2\u20133 cm in width and 4\u20135 cm in length?", "Can you identify an object that would weigh between 5 and 10 grams?", "Does the image show a region with an irregularly triangular shape, reflecting both external and internal nasal contours?", "Is there a part that appears skin-colored on the outside and pinkish on the inside?", "Can you see a structure composed of skin, cartilage, bone, mucosa, connective tissue, and blood vessels?", "Does the image contain an area likely to include cell types such as keratinocytes, chondrocytes, osteocytes, epithelial cells, goblet cells, or endothelial cells?", "Is there a region with a thickness ranging from 2 to 6 mm depending on the location?", "Can you identify a structure with an estimated volume of 2\u20134 milliliters?", "Is there an object whose water content is likely to be about 60\u201370% by weight?", "Does the image show a structure with a density close to that of soft tissue, approximately 1.05 g/cm\u00b3?", "Is there a region where cartilage makes up a significant portion, especially in the anterior part, comprising up to 40\u201350% of the structure?", "Can you see an area where bone is mainly present in the upper and posterior regions, accounting for about 10\u201320% of the total mass?", "Does the image include a mucosal surface area estimated to be between 8 and 12 cm\u00b2?", "Is there evidence of high vascularization, such as a dense capillary network supporting a mucosal surface?", "Can you identify a region where the mucosal pH would likely range from 6.3 to 6.8?", "Does the image show a structure with moderate to high nerve fiber density, supporting sensory and autonomic functions?", "Is there an area where the epithelial thickness is generally between 30 and 100 micrometers depending on the region?", "Can you see a region with low fat content, primarily limited to subcutaneous tissue?", "Is there a structure where the mineral composition is mainly calcium and phosphate in the bony regions?", "Does the image show a region with an average temperature close to core body temperature, around 33\u201335\u00b0C?"], "relational": ["Does the image display a section that includes the left nasal cavity along with its internal structures?", "Can you identify a region that contains both the nasal septum and the lateral nasal wall?", "Is there a visible area corresponding to the external part of the nose on the left side?", "Does the image show regions such as the left nasal vestibule, the left respiratory region, or the left olfactory region?", "Can you see bones like the left nasal bone, left maxilla, left ethmoid bone, or the left inferior nasal concha?", "Are there cartilaginous structures present, such as the left lateral nasal cartilage, left alar cartilage, or septal cartilage?", "Is there evidence of adjacent sinuses, such as the left maxillary sinus, left ethmoidal air cells, or left frontal sinus?", "Can you observe the division of the nasal cavity into left and right halves by a central structure?", "Are tissues such as nasal mucosa, submucosa, cartilage, bone, or skin exposed in the section?", "Does the image contain anatomical features that are part of both the respiratory and olfactory systems?", "Can you identify nerves such as branches of the olfactory nerve, the anterior ethmoidal nerve, or the infraorbital nerve?", "Are there visible blood vessels that could be branches of the facial artery, sphenopalatine artery, or anterior ethmoidal artery?"], "contexual_behavior": ["Does the image show evidence of partial obstruction or collapse of the nasal airway on one side, potentially impairing normal airflow?", "Can you identify signs of reduced olfactory function on the left side, such as disruption of the olfactory epithelium or altered airflow to the olfactory region?", "Is there visual indication of interrupted mucociliary clearance or ciliary dysfunction on one side of the nasal cavity?", "Does the image suggest a decrease in the ability to humidify inspired air due to reduced mucosal lining or altered airflow on one side?", "Can you observe features that would compromise filtration of airborne particles, such as diminished mucosal surface area or ciliary action on the left side?", "Is there evidence of impaired warming of inhaled air, possibly due to partial removal of vascularized mucosa or bypassed airflow pathways?", "Does the image indicate increased susceptibility to nasal infections, such as disrupted mucosal defenses or impaired mucociliary clearance on one side?", "Can you see signs of compromised physical or immunological barriers in the nasal mucosa that would reduce defense against pathogens?", "Is there an alteration in the volume or shape of the nasal cavity that could affect the resonance of the voice or nasal sound quality?", "Does the image reveal disruption or narrowing of anatomical pathways for mucus flow, potentially affecting nasal drainage?", "Can you identify features suggesting impaired immune response in the nasal mucosa, such as reduced immune cell populations or compromised mucosal integrity?", "Is there evidence of limited airflow to the olfactory region or mucosal irritation that could decrease the efficiency of odor detection, especially during exposure to irritants?", "Does the image suggest asymmetrical airflow patterns in the nasal passages that might become more pronounced during exercise?", "Can you observe features that would reduce the nose\u2019s ability to protect the lower airways from allergens, such as compromised filtration or mucociliary clearance?", "Is there visual evidence of impaired nasal function during episodes of allergic rhinitis, such as diminished mucosal surface area or immune response on one side?"], "functions": ["Does the image show evidence of partial loss of nasal structure on one side, potentially leading to compromised airflow and function?", "Is there an asymmetry in the nasal region that could result in reduced airflow on the left and possible compensatory breathing on the right?", "Can you identify a structural change that might cause diminished olfactory capability on one side, leading to a decreased sense of smell?", "Does the image suggest impaired mucociliary clearance on the left, which could increase the risk of infection or mucus accumulation?", "Is there a visible alteration that would compromise the humidification and filtration of inhaled air on one side of the nasal cavity?", "Can you see any disruption in the nasal structure that might affect the resonance of the voice or cause hyponasal speech?", "Does the image indicate a reduction in mucosal surface area that could decrease local immune defense or disrupt barrier function?", "Is there evidence of decreased surface area in the nasal passage that might impair the warming of inhaled air?", "Can you observe any abnormality that could interfere with the drainage of nasal secretions on the left, increasing the risk of sinus blockage?", "Does the image suggest a condition that might indirectly diminish the sense of taste by reducing olfactory input?"]}, "no_questions": {"contexual_properties": ["Can you see disrupted cell junctions, as might occur in epithelial injury or certain genetic disorders?", "Can you observe increased fibrous tissue, as would be expected in chronic inflammation or scar formation?", "Does the image show regions with heightened staining intensity, suggestive of hyperchromasia or inflammation?"], "properties": ["Is the typical number of nuclei per cell one, or are there occasionally multiple nuclei visible?", "Are the contours or borders of structures well-defined, poorly defined, or irregular?", "Are inclusions absent, few, or numerous within the observed structures?"], "relational": ["Can you see histological structures such as glands, basement membranes, capillaries, or follicles?", "Does the image show features that reflect the arrangement of cells or the organization of the extracellular matrix?", "Is there a region in the image that could correspond to anatomical sites like skin, liver, kidney, or lung?"], "contexual_behavior": ["Can you identify features such as cytopathic effects or immune cell infiltration that might suggest infection?", "Is there decreased trabecular thickness or increased bone porosity in bone tissue consistent with osteoporosis?", "Are there red blood cells with sickle shapes or membrane distortion that could be associated with sickle cell disease?"], "functions": ["Is there visual evidence of tissue regeneration or repair, such as new cell growth or restoration of normal structure?", "Does the image highlight features suggestive of malignancy, infection, or tissue injury?", "Does the image display evidence of tissue dysfunction, such as degeneration, necrosis, or abnormal architecture?"]}}, "patency": {"yes_questions": {"contexual_properties": ["Does the image show evidence of narrowing or blockage within a vessel or duct, such as might be seen with stenosis or obstruction?", "Can you identify any features suggesting that a passage has been widened or cleared, as would occur after dilation or recanalization?", "Is there a visible lumen that appears partially or completely obstructed, possibly due to atherosclerosis, tumor compression, or embolism?", "Does the image show signs of a therapeutic intervention, such as stent placement or surgical bypass, that could restore flow through a previously blocked passage?", "Can you see any material or tissue, such as a blood clot, calculus, or tumor, that might be blocking a vessel or duct?", "Are there visual indications of swelling, edema, or cellular infiltration that could be compromising the openness of a passage, as seen in vasculitis or inflammation?", "Does the image reveal the presence of thrombi or emboli that could partially or completely block a vessel?", "Is there evidence of a procedure, such as angioplasty or surgical removal, that may have improved the openness of a passage?", "Can you identify any buildup, such as atherosclerotic plaque or lipid deposition, that could be narrowing the lumen of a vessel?", "Are there signs of lesions or masses that might indicate disease progression affecting the openness of a passage, such as tumor growth or recurrent stenosis?", "Does the image show features of trauma, such as swelling, hematoma, or hemorrhage, that could alter the openness of a vessel or duct?", "Is there evidence of transient narrowing, possibly due to vessel spasm or smooth muscle contraction?", "Can you see signs of chronic narrowing or fibrosis, such as might occur with chronic inflammation or chronic thrombosis?", "Does the image suggest that a dilation procedure, like balloon angioplasty or endoscopic dilation, has been performed to widen a passage?", "Are there indications of scar tissue, stricture, or adhesion formation that could be limiting the openness of a vessel or duct?"], "properties": ["Does the image show a tubular structure that appears open and unobstructed, allowing for the passage of fluids or air?", "Can you identify a region where the lumen diameter seems normal and there is no significant narrowing?", "Is there visual evidence of unobstructed passage within any tubular structure present?", "Does the image suggest that flow through a structure is not impeded by narrowing or blockage?", "Can you see any features that might indicate the use of imaging or flow measurement techniques, such as angiography or ultrasound, to assess openness?", "Is there a structure whose diameter could be estimated in millimeters based on the image?", "Does the image provide visual cues that could help assess the duration for which a structure remains open?", "Can you identify any signs of full openness without evidence of stenosis or blockage?", "Is there any indication of narrowing that could be caused by factors such as atherosclerosis, thrombosis, inflammation, or external compression?", "Does the image allow you to determine if a structure meets the minimum diameter or flow rate required for adequate physiological function?", "Can you visually assess whether a structure has reached a critical minimum diameter or minimal flow that is still sufficient for physiological needs?", "Is there evidence of a structure exhibiting the widest diameter or highest flow rate typical of healthy, non-dilated conditions?"], "relational": ["Does the image show a blood vessel, duct, or airway that appears open and unobstructed?", "Can you identify a structure in the cardiovascular or respiratory system that maintains an open passage?", "Is there evidence of an artery or vein that allows for uninterrupted flow?", "Does the image include a bronchus, urethra, or bile duct that appears to be free of blockage?", "Can you see tissues such as smooth muscle or cartilage supporting the openness of a tubular structure?", "Is there a region like the trachea, esophagus, or ureter that appears structurally unobstructed?", "Does the image provide visual cues about the openness of a coronary artery or bronchiole?", "Can you identify an intestinal lumen or ureter that appears to be patent?", "Is there a visible anatomical connection, such as a vascular graft or anastomosis, that remains open?", "Does the image show a ductal opening, such as a bile duct or pancreatic duct, that is not occluded?", "Can you assess the patency of a peripheral artery, vein, or shunt in the image?", "Is there a structure lined by endothelium or epithelium that appears to maintain an open channel?", "Does the image suggest that a fallopian tube or nasolacrimal duct is unobstructed?", "Can you see any evidence of loss of openness in a tubular organ, such as narrowing or blockage?"], "contexual_behavior": ["Does the image show evidence of a blood vessel whose lumen is narrowed, possibly due to vascular disease such as atherosclerosis or stenosis?", "Can you identify a vessel that appears more open following a procedure like angioplasty or stenting?", "Is there a vessel in the image that appears obstructed by a blood clot, suggesting thrombosis?", "Does the image reveal a vessel with a stent that is now narrowed again, possibly due to restenosis or stent thrombosis?", "Can you see signs of chronic inflammation in a vessel, such as thickened walls or fibrosis, that might reduce openness?", "Is there a vessel that appears more open and free of clots, possibly as a result of anticoagulant therapy?", "Does the image show a blood vessel being compressed or invaded by a tumor or neoplastic tissue?", "Is there evidence of vascular injury, hemorrhage, or spasm in the context of acute trauma that could compromise vessel openness?", "Can you identify a vessel that appears more open after the dissolution of a clot, possibly following thrombolytic treatment?", "Does the image show narrowed or occluded vessels that could be related to diabetic vasculopathy?", "Is there a vessel that remains blocked after surgical repair, possibly due to postoperative thrombosis or technical failure?", "Can you see a vessel with increased diameter, suggesting smooth muscle relaxation and vasodilation?", "Is there evidence of atherosclerotic plaque formation within a vessel, leading to lumen obstruction?", "Does the image show vessel wall thickening or narrowing that could be due to immune-mediated inflammation, as seen in autoimmune vasculitis?", "Can you identify a vessel that appears more open after the removal of a blockage, such as a thrombus or foreign body?", "Is there a vessel that remains persistently blocked, possibly due to chronic occlusion that resists intervention?", "Does the image show a collapsed or poorly perfused vessel that could be associated with severe hypotension?", "Can you see signs of improved vascular health, such as wider vessel lumens, that might result from lifestyle modifications?", "Is there a vessel that appears obstructed by a clot, possibly due to a hypercoagulable state?", "Does the image reveal vessel narrowing or occlusion that could be a consequence of radiation therapy-induced vascular injury and fibrosis?"], "functions": ["Does the image show a structure with an open lumen that would allow for unobstructed passage?", "Can you identify a vessel or tube that appears free of narrowing or occlusion, supporting continuous blood flow?", "Is there evidence of airway openness that would enable effective respiration and gas exchange?", "Does the image contain ducts or tubular structures that would permit free movement of fluids such as bile or urine?", "Can you see any indication that organ function is preserved by the maintenance of normal flow and absence of obstruction?", "Is there a visible pathway where blockage is absent, helping to prevent ischemia or impaired organ performance?", "Does the image show clear pathways for fluid, air, or cellular movement, supporting normal physiological processes?", "Can you identify vessels or capillaries that appear open, facilitating nutrient delivery and oxygen transport?", "Is there a structure that would allow efficient removal of metabolic byproducts through veins or excretory ducts?", "Does the image show glandular ducts that are unobstructed, enabling the movement of secretions such as saliva or hormones?"]}, "no_questions": {"contexual_properties": ["Is there evidence of heterogeneity within a mass, suggesting genetic diversity or adaptation to the microenvironment?", "Does the image reveal a mass with variable texture, possibly due to fibrosis, necrosis, or effects of treatment?", "Does the image contain regions of necrosis, which might result from ischemia or cytotoxic therapy?"], "properties": ["Are there signs of increased mitotic activity, such as frequent mitotic figures?", "Can you see features consistent with a basal-like molecular subtype, such as positivity for cytokeratin 5/6 or EGFR?", "Is there evidence of complex chromosomal aberrations, such as gains on chromosomes 1q or 8q?"], "relational": ["Can you see histological features consistent with invasive ductal carcinoma or medullary carcinoma?", "Is there a tumor mass present in the breast ducts or lobular units?", "Does the image show areas where biomarkers such as progesterone receptor or Ki-67 might be assessed alongside ER and HER2?"], "contexual_behavior": ["Is there evidence of increased cell migration in the presence of inflammatory cytokines like IL-6 or TNF-\u03b1?", "Is there evidence of increased cell cycle progression, possibly following the loss of tumor suppressors such as p53 or RB?", "Is there evidence of cells that change their function in response to chemotherapy or develop resistance to drugs?"], "functions": ["Does the tumor exhibit characteristics associated with a high risk of distant organ spread or metastasis?", "Can you distinguish a neoplasm with a distinct molecular profile or unique therapeutic vulnerabilities compared to hormone-dependent subtypes?", "Are there visual cues indicating dysregulation of DNA repair, cell cycle, or immune evasion mechanisms?"]}}, "right side": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling on one side that could suggest infection, trauma, or lymphatic obstruction?", "Can you observe discoloration on a lateral region that might indicate bruising or a skin disorder?", "Is there an area that appears enlarged, possibly due to edema, tumor, or tissue hypertrophy?", "Do you see any region that looks smaller or wasted, which could be due to muscle atrophy or chronic ischemia?", "Is there a part that might be tender, as suggested by signs of inflammation or injury?", "Can you identify any abnormal texture, such as fibrosis, scarring, or a subcutaneous mass, on one side?", "Is there visible fluid accumulation in a lateral area, possibly related to edema or heart failure?", "Does any region appear warmer, which could be due to infection, inflammation, or increased blood flow?", "Is there an area that seems cooler, potentially indicating poor circulation or arterial insufficiency?", "Can you detect changes in tissue density, such as those caused by tumors, fibrosis, or fluid buildup?", "Is there a region that appears more rigid, possibly due to fibrosis, contracture, or chronic inflammation?", "Do you notice any loss of mass or muscle wasting on one side, which might be related to chronic disease?", "Is there an abnormal growth, such as a neoplasm, cyst, or benign tumor, present on a lateral aspect?", "Can you see increased redness, which could be a sign of erythema, cellulitis, or an allergic reaction?", "Is there a pale area that might suggest anemia, poor perfusion, or vasoconstriction?", "Do you observe bruising on one side that could be due to trauma or a vascular injury?", "Is there any region that might be more sensitive, possibly due to neuropathy or nerve irritation?", "Can you identify numbness or reduced sensation in a lateral area, which might be caused by nerve compression or ischemia?", "Are there any structural changes, such as those resulting from congenital anomalies, trauma, or degeneration, visible on one side?", "Do you see signs of edema in a lateral region, possibly associated with heart failure or venous insufficiency?"], "properties": ["Does the image show a region defined by the midsagittal plane dividing the body into two halves?", "Can you identify an area that serves as the lateral boundary relative to the body's midline?", "Is there a section containing structures such as the right lung, right kidney, right lobe of the liver, or right atrium?", "Does the image display bilateral symmetry, with one side mirroring the other?", "Can you see a region that appears to occupy approximately half of the body's width?", "Is there an area that represents about half of the total external body surface area?", "Does the image include a region whose volume is roughly half of the total body volume, accounting for possible anatomical variation?", "Is there a part of the illustration that is highlighted in blue or shown in natural skin tones to distinguish one side?", "Can you identify an area composed of skin, muscle, bone, nerves, and organs typically found on one side of the body?", "Does the tissue density in a particular region appear similar to that of the opposite side, averaging around 1.06 g/cm\u00b3 for soft tissue?", "Is there a region that would be expected to have a temperature consistent with core body temperature, approximately 36.5\u201337.5\u00b0C?"], "relational": ["Does the image show anatomical regions such as the right thorax or right abdomen?", "Can you identify organs typically found on one side, such as the right lung or gallbladder?", "Is there a visible structure that could be the right kidney or a portion of the right colon?", "Does the image contain bones like the right humerus, right femur, or right scapula?", "Can you see muscles such as the right deltoid or right quadriceps femoris?", "Is there evidence of bilateral symmetry, with mirrored structures on both sides of the body?", "Does the image show major blood vessels like the right subclavian artery or right femoral vein?", "Can you identify nerves such as the right brachial plexus or right sciatic nerve?", "Are there visible components of the nervous, circulatory, musculoskeletal, or lymphatic systems on one side?", "Does the image include lymph nodes such as the right axillary or right inguinal lymph nodes?", "Can you see anatomical landmarks like the right midclavicular line or right iliac crest?", "Is there a structure that corresponds to the right costal margin or right anterior superior iliac spine?"], "contexual_behavior": ["Does the image show evidence of a cardiac chamber that may be pumping blood less efficiently, as seen in conditions like ventricular dysfunction or heart failure?", "Is there a structure that appears unable to deliver blood to the lungs properly, which could indicate heart failure or severe pulmonary valve narrowing?", "Can you identify signs of impaired motor function on one side of the body that might result from a stroke affecting the opposite cerebral hemisphere?", "Does the image suggest increased workload in a heart chamber due to elevated resistance in the pulmonary arteries, as seen in pulmonary hypertension?", "Is there a visible indication of reduced cardiac output or decreased pulmonary circulation that could be due to ventricular failure?", "Can you observe any loss of sensory perception on one side of the body, possibly related to neurological disorders such as brain lesions or demyelinating disease?", "Is there evidence of compensatory changes in a heart chamber that might be responding to dysfunction on the opposite side to maintain systemic circulation?", "Does the image reveal altered coordination on one side of the body that could result from injury to the contralateral cerebellum or motor cortex?", "Can you see signs of decreased contractility in a heart chamber that might be affected by insufficient oxygen supply?", "Is there increased muscle tone or spasticity on one side of the body, potentially following an upper motor neuron lesion in the opposite hemisphere?", "Does the image show signs of cardiac overload that could be associated with chronic lung disease or cor pulmonale?", "Is there evidence of reduced circulation in one limb, possibly due to vascular disease such as peripheral artery disease or deep vein thrombosis?", "Can you identify alterations in heart function that might be caused by a sudden obstruction of pulmonary blood flow, as in acute pulmonary embolism?", "Does the image suggest functional recovery or improved movement on one side of the body, potentially following rehabilitation after neurological injury?", "Is there a sign of impaired filling in a heart chamber that could be due to stiff ventricular walls, as seen in restrictive cardiomyopathy?"], "functions": ["Does the image show structures involved in movement or sensation on one half of the body?", "Can you identify muscles or joints that contribute to locomotion or postural stability on a specific side?", "Is there a visible region of the heart responsible for sending deoxygenated blood to the lungs?", "Does the image include a ventricle that participates in pulmonary circulation?", "Can you see any anatomical features that support balance or proprioception on one side?", "Is there evidence of organ systems, such as the respiratory or digestive system, with major components located on a particular half of the body?", "Does the image display organs like a lung or liver that are positioned laterally within the body?", "Can you identify neural structures that might be involved in transmitting motor or sensory signals across the body midline?", "Is there a region that could be responsible for autonomic regulation, such as controlling heart rate or respiratory rhythm, through lateralized pathways?", "Does the image show any features that suggest contralateral control of movement or sensation?", "Can you observe anatomical evidence of lateralization in organ or nervous system function?"]}, "no_questions": {"contexual_properties": ["Is there visual evidence of a change in heart rate, such as tachycardia, that could be a response to hypotension?", "Does the image show evidence of swelling that could have developed within minutes of exposure to an allergen?", "Can you see visible hives or urticaria that could have formed within minutes following exposure to an allergen?"], "properties": ["Are there visual cues indicating symptoms that last less than 24 hours?", "Can you see indications of decreased blood oxygen saturation, such as cyanosis?", "Does the image provide clues to elevated histamine or tryptase levels, such as pronounced skin or airway changes?"], "relational": ["Does the image suggest the release of molecules like histamine, leukotrienes, or prostaglandins?", "Can you see features consistent with a type I hypersensitivity or an IgE-mediated response?", "Can you identify cells such as mast cells, basophils, or eosinophils participating in a visible reaction?"], "contexual_behavior": ["Can you observe signs of increased reactivity following repeated exposure to the same allergen, possibly due to sensitization or memory cell activation?", "Does the image indicate altered immune cell activation or mediator release that could occur during acute infection?", "Is there any indication of impaired immunity or mast cell dysfunction that could be seen in immunodeficient patients?"], "functions": ["Does the image show features of a rapid, exaggerated immune response to a harmless antigen?", "Is there a rapid influx of immune cells or increased local blood flow visible, suggesting acute inflammation or edema?", "Can you identify signs of an IgE-mediated allergic reaction, such as mast cell activation?"]}}}
[ { "answer": "view of middle ear areas with obvious hemorrhage in under-lying tissue", "extracted_concepts": [ "middle ear areas", "obvious hemorrhage", "under-lying tissue" ], "question": "what does this image show?" }, { "answer": "with obvious hemorrhage in under-lying tissue", "extracted_concepts": [ "middle ear areas", "obvious hemorrhage", "under-lying tissue" ], "question": "how does this image show view of middle ear areas?" }, { "answer": "yes", "extracted_concepts": [ "middle ear areas", "hemorrhage", "under-lying tissue" ], "question": "does this image show view of middle ear areas with obvious hemorrhage in under-lying tissue?" }, { "answer": "no", "extracted_concepts": [ "middle ear areas", "hemorrhage", "under-lying tissue", "amyloidosis" ], "question": "does amyloidosis show view of middle ear areas with obvious hemorrhage in under-lying tissue?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "atheromatous embolus" ], "question": "is atheromatous embolus present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basilar skull fracture" ], "question": "is basilar skull fracture present?" }, { "answer": "no", "extracted_concepts": [], "question": "is this image present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" } ]	["middle ear areas", "hemorrhage", "atheromatous embolus", "bone", "amyloidosis", "under-lying tissue", "calvarium", "basilar skull fracture", "obvious hemorrhage"]	{"middle ear areas": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a cavity with a size close to 1 cubic centimeter?", "Is there a structure present with a volume between 1 and 2 milliliters?", "Can you identify an irregular, air-filled space resembling a biconcave or box-like cavity?", "Is there a region with a pale pink to light gray appearance due to a mucosal lining?", "Does the image contain an area with an estimated surface area of 6 to 8 square centimeters?", "Can you see a cavity where the air pressure would likely be equal to atmospheric pressure?", "Is there a structure whose temperature would be expected to match core body temperature, around 37\u00b0C?", "Does the image include a region that would have a slightly alkaline pH, near 7.4?", "Can you identify a space lined by ciliated columnar epithelial cells, goblet cells, or immune cells?", "Is there an area lined by a mucous membrane with both ciliated and non-ciliated epithelial cells?", "Does the image show a region where the mucosal lining would have a water content greater than 70% by weight?", "Is there a structure with tissue density similar to soft tissue, approximately 1.05 g/cm\u00b3?", "Can you see a lining with a thickness in the range of 0.1 to 0.5 millimeters?", "Is there a cavity where the oxygen concentration would be lower than atmospheric air, typically around 10-15%?", "Does the image include a space where the electrolyte concentrations would be similar to extracellular fluid, with sodium near 140 mmol/L and potassium around 4 mmol/L?"], "relational": ["Does the image show a region that is part of the auditory system?", "Can you identify an area containing structures such as the tympanic cavity or ossicles?", "Is there evidence of small bones like the malleus, incus, or stapes?", "Does the image display an opening that could be the entrance to the Eustachian tube?", "Can you see a space adjacent to both the external auditory canal and the vestibule?", "Is there a membrane visible that separates one region from the external ear?", "Does the image include features resembling the oval or round windows that separate spaces within the ear?", "Can you identify nerves such as the chorda tympani or branches of the facial or glossopharyngeal nerves in the depicted area?", "Is there evidence of blood vessels like branches of the anterior tympanic artery or stylomastoid artery supplying a particular region?", "Does the image show a structure that could transmit sound vibrations to the inner ear through a window-like opening?", "Can you see an area that receives sound waves via a membrane?", "Is there a visible connection between a cavity and the nasopharynx, suggestive of a tube-like structure?"], "contexual_behavior": ["Does the image contain a region located between the outer and inner parts of the ear?", "Is there a structure visible that could transmit sound vibrations from the eardrum to the inner ear?", "Can you identify an area that might house small bones involved in hearing?", "Does the image show a space that is not part of the external ear canal or the cochlea?"], "functions": ["Does the image show a region responsible for transmitting and amplifying sound vibrations?", "Can you identify an area that plays a role in equalizing air pressure within the ear?", "Is there a structure that protects deeper auditory components from loud noises?", "Does the image contain a region involved in converting air-borne sound waves into mechanical vibrations?", "Can you see anatomical features that relay vibrations from a membrane to a small window-like structure via tiny bones?", "Is there evidence of a tube that helps regulate pressure between the ear and the external environment?", "Does the image show muscles that could contract to dampen the movement of small bones in response to loud sounds?", "Can you identify a chain of small bones that amplify sound through lever action?", "Is there a region where the difference in surface area between two structures could contribute to sound amplification?", "Does the image reveal movement or alignment of small bones that transmit sound energy toward the cochlea?", "Can you see a passageway that might assist in draining fluids to maintain ear health?", "Is there a visible barrier or lining that could help prevent infections from reaching deeper auditory structures?", "Does the image show tissue that might participate in immune defense within the ear?"]}, "no_questions": {"contexual_properties": ["Does the image reveal compression of a cranial aperture caused by excessive bone formation, tumor presence, or herniation of nearby tissues?", "Is there evidence of structural deformity in a skull base opening that could result from genetic mutation, trauma, or chronic disease?", "Is there decreased flexibility or increased rigidity of a skull opening, potentially due to increased ossification or calcification of surrounding ligaments?"], "properties": ["Is there an indication of an elevated pressure gradient, possibly exceeding 5 mmHg, across a constricted opening at the base of the skull?", "Does the image show a structure at the cranial base that appears oval or irregular instead of round?", "Can you observe thickened bone or fibrous tissue at the site of a narrowed cranial opening?"], "relational": ["Is there evidence of compression or impingement on nerves such as the spinal accessory nerve or upper cervical spinal nerves near the craniovertebral junction?", "Can you observe displacement or crowding of cranial structures such as the cerebellar tonsils or clivus near the skull base?", "Does the image suggest an impact on the nervous or musculoskeletal systems at the junction between the skull and vertebral column?"], "contexual_behavior": [], "functions": ["Is there evidence of compromised blood flow to the brain or spinal cord, such as compression of vertebral arteries or venous pathways?", "Does the image show evidence of compression affecting neural or vascular structures at the base of the skull?", "Is there a visible narrowing that could obstruct cerebrospinal fluid flow and increase the risk of hydrocephalus?"]}}, "hemorrhage": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of disruption in vascular tissue within the cardiovascular or nervous system?", "Is there a region where blood appears to have infiltrated connective or muscle tissue?", "Can you identify signs of damage to arteries, veins, or capillaries in the depicted area?", "Is there visual evidence of tissue compression or swelling that could indicate hematoma formation?", "Does the image display abnormal accumulation of blood in the cranial, pleural, pericardial, or peritoneal cavity?", "Are there signs of blood collection within muscular compartments or subcutaneous tissue?", "Can you see any indication of edema in regions adjacent to blood vessels?", "Is there evidence of blood affecting organs such as the brain, liver, spleen, kidneys, or lungs?", "Does the image suggest that anatomical barriers like fascia, meninges, or peritoneum are limiting the spread of a fluid collection?", "Are there visual cues that suggest involvement of nervous tissue or nerves due to nearby vascular disruption?", "Can you identify blood accumulation in joint spaces or within joint capsules?", "Is there a region where surrounding organs appear affected by a nearby vascular event?", "Does the image show signs of blood infiltration in the gastrointestinal tract, lungs, skin, or muscles?"], "contexual_behavior": [], "functions": ["Does the image show evidence of reduced blood volume or impaired circulation?", "Can you identify signs of decreased tissue perfusion or organ dysfunction?", "Is there visual indication of compensatory mechanisms such as vasoconstriction or tachycardia?", "Does the image suggest diminished oxygen delivery to tissues, such as pallor or cyanosis?", "Can you see features that might indicate activation of the coagulation cascade or clot formation?", "Is there evidence of decreased blood pressure or lowered vascular resistance in the depicted structures?", "Does the image show signs consistent with shock, such as inadequate perfusion or cellular hypoxia?", "Can you identify areas with reduced perfusion or possible nutrient and oxygen deficiency?", "Is there visual evidence of the body attempting to restore homeostasis, such as fluid redistribution or increased heart rate?", "Does the image suggest increased erythropoiesis or compensatory responses to oxygen deficit?", "Can you see indications of impaired organ function or reduced blood supply that could lead to organ failure?"]}, "no_questions": {"contexual_properties": ["Can you identify a ductal abnormality characterized by the presence of multiple papillary growths and areas resembling apocrine metaplasia?", "Is there evidence of epithelial changes within a ductal lesion that suggest transformation toward apocrine cell characteristics?", "Does the image show a lesion within a ductal structure that contains multiple papillary projections?"], "properties": ["Can you see a region where the Ki-67 proliferation index would likely be low?", "Does the image show cells with abundant eosinophilic granular cytoplasm?", "Can you identify an area that appears tan-pink to whitish in color?"], "relational": ["Is there evidence of changes within lactiferous ducts or terminal duct-lobular units?", "Does the image show a lesion involving the mammary gland system?", "Can you identify any abnormalities affecting mammary ducts or breast lobules?"], "contexual_behavior": ["Does the image show any abnormal growths within a ductal structure?", "Does the image contain features suggestive of epithelial proliferation within a duct?", "Can you identify areas where the lining of a duct appears to have undergone a change resembling apocrine cells?"], "functions": ["Can you see papillary growths or projections expanding the ductal lumen?", "Does the image suggest increased or modified secretion within the ducts?", "Does the image show expansion of the ductal lumen due to intraluminal growths?"]}}, "atheromatous embolus": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show any structures measuring between 100 micrometers and several millimeters in size?", "Can you identify any objects with an irregular or fragmented shape?", "Is there a structure composed mainly of cholesterol crystals, lipids, calcium, and cellular debris?", "Do you see any areas with a yellowish-white coloration?", "Is there evidence of a structure with a high cholesterol content?", "Can you find an object with substantial lipid content, primarily due to cholesterol and other lipids?", "Are there regions containing microcalcifications or variable amounts of calcium?", "Does the image reveal a structure with a friable and granular texture?", "Is there an object with heterogeneous density, reflecting a mixture of lipids, calcium, and cellular material?", "Can you observe single or multiple similar structures within a vessel?", "Are there cells such as macrophages, foam cells, or smooth muscle cells present within a structure?", "Is there a region with moderate protein content, mainly from cellular debris and extracellular matrix proteins?", "Do you see any structures with relatively low water content compared to normal blood clots?", "Is there a visible accumulation of crystalline material, particularly cholesterol crystals, in significant amounts?", "Can you identify any objects with a thickness ranging from 0.1 to several millimeters?"], "relational": ["Does the image show evidence of obstruction in arteries or arterioles?", "Can you identify any signs of vascular blockage affecting the cerebral or renal circulation?", "Is there a structure that could originate from arterial plaques, such as material from the aorta or carotid arteries?", "Does the image contain features consistent with cholesterol crystals or lipid debris within a blood vessel?", "Can you see any tissue changes in the brain, renal cortex, or peripheral tissues that might result from downstream vascular obstruction?", "Is there evidence of compromised blood flow to the brain, kidneys, or lower limbs?", "Does the image suggest the presence of foam cells or other components associated with arterial embolization?", "Can you identify any vascular territories, such as the cerebral or peripheral arteries, that appear affected by embolic material?", "Is there a visible relationship between atherosclerotic plaque rupture and material found within a vessel?", "Does the image show any anatomical evidence of embolic events impacting the lower extremities?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structure causing vascular obstruction within an artery?", "Is there a visible blockage within a blood vessel that could impede normal blood flow?", "Can you identify a region where arterial blockage might be leading to embolic occlusion?", "Does the image suggest tissue ischemia due to lack of oxygenated blood supply downstream of a vessel?", "Is there an area of decreased perfusion to an organ that could be explained by arterial obstruction?", "Can you see signs of tissue necrosis or infarction that might result from prolonged arterial blockage?", "Is there evidence of an inflammatory response, such as leukocyte accumulation, at the site of a vascular blockage?", "Does the image show microvascular obstruction, such as blocked small arterioles or capillaries, leading to localized hypoxia?", "Can you identify features suggesting organ dysfunction or ischemic damage due to compromised blood supply?", "Is there a region in the brain where a cerebral artery appears occluded, potentially indicating a focal ischemic event?", "Does the image display characteristics of an acute vascular event, such as sudden arterial occlusion and tissue injury?"]}, "no_questions": {"contexual_properties": [], "properties": ["Do you observe radiopaque (white) lines radiating outward from a central lesion?", "Is there a region in the image where fine, radiating lines extend outward from a central lesion?", "Are there fibrous, irregular textures visible at the periphery of a mass?"], "relational": ["Can you see a mass whose margins suggest a desmoplastic response or fibrosis in the adjacent tissue?", "Is there a lesion with features consistent with neoplastic or malignant growth, such as spiculated extensions?", "Is there a structure whose outwardly radiating margins suggest infiltrative growth or irregular extension into the surrounding tissue?"], "contexual_behavior": ["Can you see a lesion where the definition of radiating margins appears altered, potentially due to rapid cellular proliferation and changes in the surrounding stroma?", "Is there evidence of radiating margins that have decreased in visibility, which could indicate a response to cancer therapy or tumor regression?", "Can you observe any changes in the radiating pattern of a lesion that might reflect hormonal influences on stromal composition or tissue density?"], "functions": ["Is there a lesion with characteristics of deep or broad tissue infiltration, implying biological aggressiveness?", "Is there visual evidence of a lesion facilitating local invasion or resisting containment, contributing to disease progression?", "Can you see features that might indicate local cellular spread or potential for metastasis?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Are there any lesions present that might suggest infection, autoimmune disease, or neoplastic processes?", "Is there a visible loss of elasticity, such as sagging or wrinkling, that could be related to aging or connective tissue disorders?", "Is there evidence of thickened plaques that might suggest chronic psoriasis or discoid lupus erythematosus?"], "properties": ["Can you see an area with a high density of sebaceous glands, around 80 to 100 glands per square centimeter?", "Is there a region where the lipid content might be about 10 to 15 percent of the outermost layer by weight?", "Is there a region in the image that appears to have a thickness between 5 and 7 millimeters?"], "relational": ["Does the image include a soft tissue covering that provides protection for the cranial bones?", "Can you identify an area composed of multiple layers, including skin and connective tissue?", "Can you see an area that might receive blood supply from branches such as the superficial temporal or occipital arteries?"], "contexual_behavior": ["Is there an area where hair growth appears reduced, possibly due to hormonal changes such as menopause or thyroid disorders?", "Is there evidence of an increased inflammatory response, such as immune cell recruitment or cytokine production, in the presence of infection?", "Does the image suggest impaired moisture retention, such as dryness or increased transepidermal water loss, possibly due to dehydration?"], "functions": ["Can you see an area that might facilitate sensory perception, such as detecting touch or temperature?", "Is there a region that could participate in wound healing by supporting tissue repair or local immune responses?", "Does the image display features consistent with shock absorption, such as connective or fatty tissue layers?"]}}, "amyloidosis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show abnormal protein deposits that could be composed of misfolded proteins such as amyloid A, amyloid light chain, or transthyretin?", "Can you identify areas where up to 10\u201330% of the tissue volume appears occupied by extracellular material?", "Is there evidence of deposits with a diffuse, perivascular, or nodular distribution pattern within the tissue?", "Does the image reveal material that stains salmon-pink to orange-red with Congo red dye?", "Is there a region that would display apple-green birefringence under polarized light microscopy?", "Can you see structures that might have a cross-beta sheet molecular arrangement?", "Is there evidence of fibrillar material with an average diameter of approximately 7\u201310 nanometers?", "Are there abnormal deposits present in organs such as the kidneys, heart, liver, spleen, or nervous system?", "Does the image show extracellular material likely composed of protein fibrils, glycosaminoglycans, or serum amyloid P component?", "Is there a region that would be positive for amyloid P, specific precursor proteins, or Congo red on immunohistochemical staining?", "Does the tissue appear to maintain a normal pH close to 7.35\u20137.45 despite the presence of abnormal deposits?", "Are there non-branching, linear fibrils arranged in bundles visible under electron microscopy?", "Can you identify areas where the amount of abnormal protein might range from low to elevated, depending on disease severity?", "Is there material that shows moderate to strong staining intensity with Congo red?", "Do you observe deposits that appear insoluble in water and most physiological solvents?"], "relational": ["Is there evidence of structural changes such as tissue stiffening or organ enlargement in any organ that could indicate impaired function?", "Can you identify alterations in organs like the heart, kidneys, liver, or spleen that might suggest abnormal protein accumulation?", "Does the image show features consistent with involvement of the cardiovascular, renal, nervous, or gastrointestinal systems?", "Is there visible evidence of changes in connective, nervous, cardiac, or renal tissues?", "Can you see any abnormalities in anatomical regions such as the myocardium, glomeruli, liver parenchyma, or peripheral nerves?", "Are there signs of plasma cell or macrophage presence associated with abnormal extracellular deposits?", "Does the image suggest involvement of the lymphatic system, such as lymph node changes or impaired drainage?", "Is there any indication of altered stroma, basement membrane, or extracellular matrix within the tissues?", "Can you observe features that might be related to restrictive cardiomyopathy, arrhythmias, or heart failure?", "Is there visual evidence that could suggest the presence of abnormal proteins in blood plasma, urine, or cerebrospinal fluid?"], "contexual_behavior": [], "functions": ["Does the image show evidence of organ dysfunction that could be caused by the accumulation of insoluble fibrils in tissues?", "Is there a structure where healthy tissue appears to be replaced by abnormal deposits, potentially impairing physiological processes?", "Can you identify areas with extracellular material accumulation that might lead to tissue stiffness or loss of normal function?", "Does the image display any signs of glomerular changes that could be associated with impaired filtration, such as features suggestive of proteinuria or renal insufficiency?", "Is there evidence of myocardial infiltration that could result in restrictive cardiac motion or arrhythmias?", "Can you observe any abnormalities in peripheral nerves that might indicate neuropathy or sensory deficits?", "Does the image reveal an enlarged liver or features suggesting reduced metabolic or detoxification capacity?", "Are there blood vessels that appear fragile or show signs of impaired perfusion, such as hemorrhage or ischemic changes?", "Can you see indications of fluid imbalance, such as edema or effusions, that might be linked to nephrotic syndrome or hypoalbuminemia?", "Is there evidence of gastrointestinal tract infiltration that could result in malabsorption or abnormal motility?", "Does the image suggest damage to endocrine organs that could lead to hormone imbalance or altered secretion?", "Are there lymphoid tissues that appear infiltrated or compromised, potentially indicating reduced immune function?", "Can you identify tissue regions where abnormal protein aggregation or impaired clearance mechanisms might be present?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show disruption of connective tissues such as fascia, ligaments, or adipose tissue beneath the skin?", "Does the image show an area where the skin, subcutaneous tissue, or underlying muscle appears damaged?", "Can you see any signs of compromised tissue integrity that might increase infection risk?"], "contexual_behavior": ["Is there evidence of increased exudate or fluid accumulation in a foot wound, which could indicate bacterial colonization and inflammation?", "Does the wound lack granulation tissue, potentially as a result of chronic ischemia or impaired angiogenesis?", "Does the image show a wound that appears less responsive to standard care, suggesting an immunocompromised state or impaired healing?"], "functions": ["Can you identify features consistent with chronic pain or nerve exposure in the region of a heel wound?", "Can you observe any disruption to normal cell proliferation, angiogenesis, or extracellular matrix remodeling in the affected heel tissue?", "Is there visual indication of prolonged inflammation or delayed healing in a wound located on the heel?"]}}, "under-lying tissue": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling beneath the surface that could indicate edema or inflammation?", "Can you observe any color changes under the surface, such as bruising or pallor, that might suggest ecchymosis or ischemia?", "Is there a region beneath the visible layer that appears inflamed, possibly due to infection or trauma?", "Do you see any areas under the surface that appear shrunken or reduced in volume, which could indicate atrophy or necrosis?", "Is there a thickened area beneath the surface that might be due to fibrosis or hypertrophy?", "Can you identify any hardened regions under the surface that could result from calcification or chronic inflammation?", "Is there a portion beneath the surface that appears unusually soft, possibly due to liquefactive necrosis or enzymatic degradation?", "Do you notice abnormal texture changes under the surface, such as those seen with edema or tumor formation?", "Is there increased vascularity beneath the surface, which might be a sign of angiogenesis during wound healing or neoplasia?", "Can you see any loss of elasticity in the tissue beneath the surface, potentially due to fibrosis or aging?", "Are there areas under the surface with increased cellularity, as seen in hyperplasia or neoplastic processes?", "Is there evidence of calcifications beneath the surface, which could be related to chronic injury or metabolic disease?", "Do you observe fluid accumulation under the surface, suggesting edema or lymphatic blockage?", "Is there any sign of hemorrhage beneath the surface, such as localized bleeding after trauma or vascular injury?", "Can you identify pallor under the surface, which might indicate anemia or hypoperfusion?", "Is there evidence of fatty infiltration beneath the surface, as seen in metabolic disorders or obesity?", "Do you see scar tissue formation under the surface, possibly resulting from previous injury or chronic inflammation?"], "properties": ["Is there a structure visible that appears as a pale pink to whitish layer beneath another tissue?", "Can you identify a region that might contain connective tissue fibers and extracellular matrix?", "Does the image show an area that could have a thickness between 1 and 10 millimeters, varying by anatomical location?", "Is there evidence of a layer that might include adipocytes or fat cells?", "Can you see a region that could contain blood vessels and interstitial fluid?", "Is there a structure that may be moderately elastic, allowing for deformation and recovery?", "Does the image suggest the presence of a layer with high collagen content, up to 30% of its dry weight?", "Can you identify an area where the fat content could range from 10% to 50%, depending on location?", "Is there a region that might contain fibroblasts, endothelial cells, or immune cells?", "Does the image show a layer likely to have a water content of about 60% to 70% by weight?", "Is there a structure that would be expected to have a density close to 1.05 grams per cubic centimeter?", "Can you see a region that would typically have a slightly alkaline pH, between 7.35 and 7.45?", "Is there an area that would be expected to have a temperature near core body temperature, around 36 to 37 degrees Celsius?", "Does the image suggest a layer with a protein concentration of approximately 20 to 30 grams per kilogram?", "Can you identify a region where mineral content is low, with only trace amounts of calcium and phosphate?", "Is there a structure that could have a glucose level similar to interstitial fluid, typically 4 to 6 mmol/L?", "Does the image show an area where the oxygen level might range from 20 to 40 mmHg, depending on vascular supply?"], "relational": ["Does the image show a region that is part of the integumentary, musculoskeletal, or digestive system?", "Is there a structure visible that is covered by an epidermis, mucous membrane, or epithelial layer?", "Can you identify tissue beneath the skin that could be classified as connective, subcutaneous, or loose areolar tissue?", "Is there a layer situated directly below the epidermis, dermis, or epithelial layer?", "Does the image include an organ such as skin, a mucosal organ, or muscle that is supported by a deeper tissue layer?", "Can you see a structure beneath the skin that might provide structural support or insulation?", "Is there evidence of adipose, areolar, or dense irregular connective tissue beneath a surface layer?", "Does the image show blood vessels, nerves, or hair follicles interacting with a deeper tissue layer?", "Is there a region depicted from the scalp, abdomen, limbs, or oral cavity that contains a layer beneath the surface?", "Can you identify tissue containing cell types such as fibroblasts, adipocytes, macrophages, or mast cells beneath a covering layer?"], "contexual_behavior": ["Does the image show a region where structural support appears compromised, possibly due to disruption of the extracellular matrix after injury?", "Is there evidence of reduced nutrient supply to overlying layers, such as areas with poor vascularization or signs of ischemia?", "Can you identify tissue that appears to be undergoing increased regeneration, possibly in response to trauma or growth factor activity?", "Does the image display impaired wound healing, particularly in the context of diabetes mellitus or poor perfusion?", "Is there a region where cushioning seems diminished, perhaps due to chronic inflammation or loss of connective tissue components?", "Can you see tissue that appears more susceptible to infection following skin breakdown or exposure to pathogens?", "Is there evidence of decreased oxygen delivery, such as regions affected by vascular compromise or hypoxia?", "Does the image show an area with heightened inflammatory response, possibly after exposure to toxins or immune cell activation?", "Can you identify tissue that seems unable to regulate temperature effectively, especially under hypothermic conditions or reduced metabolic activity?", "Is there a region where metabolic activity appears altered, such as areas under prolonged pressure that might be prone to pressure ulcers?", "Does the image reveal tissue that fails to support the overlying epithelium, potentially as a result of aging or extracellular matrix degradation?", "Can you see signs of increased fibrosis, such as enhanced fibroblast activity or collagen deposition after repeated injury?", "Is there evidence of reduced immune defense, for example in immunocompromised states with impaired pathogen response?", "Does the image show enhanced vascular supply, such as new blood vessel formation during tissue repair or angiogenesis?", "Can you identify tissue that fails to buffer mechanical stress, possibly due to connective tissue disorders or abnormal collagen structure?"], "functions": ["Is there a structure visible that provides support or protection to the layers above it?", "Can you identify a region that acts as a cushion or anchor for overlying anatomical structures?", "Does the image show an area that could be involved in storing nutrients or energy?", "Is there evidence of a tissue layer that participates in wound healing by supplying cells or growth factors?", "Can you see a region with vascular networks that might deliver oxygen and nutrients to the skin?", "Is there a structure that appears to absorb mechanical shocks or distribute pressure away from delicate organs?", "Does the image contain a layer that could insulate the body and help regulate temperature?", "Can you identify an area that might house immune cells for defense against pathogens or injury?", "Is there a region where energy could be stored in the form of lipids within specialized cells?", "Does the image show a tissue layer that could facilitate cell migration or provide a scaffold for new tissue formation during repair?", "Can you see evidence of blood or lymphatic vessels that might aid in the removal of waste products from overlying layers?"]}, "no_questions": {"contexual_properties": ["Can you identify a vessel with reduced blood flow, which could be caused by stenosis or thrombosis?", "Is there evidence of an aneurysm in a vessel, possibly resulting from wall weakening due to a connective tissue disorder?", "Is there a vessel in the image that appears narrowed, possibly due to plaque buildup or vasospasm?"], "properties": ["Is there a structure that would typically experience pressures between 80 and 120 mmHg during the cardiac cycle?", "Does the image show a vessel wall that appears to be 1 to 2 millimeters thick?", "Can you see a vessel whose tissue pH would be expected to be between 7.35 and 7.45?"], "relational": ["Does the image include branches such as the left anterior descending artery or circumflex artery?", "Can you identify a structure adjacent to the pericardium?", "Is there a vessel present that delivers blood to the endocardium or epicardium?"], "contexual_behavior": ["Can you see a structure whose blood flow could be reduced during severe hypotension due to decreased perfusion pressure?", "Does the image contain a vessel that could lose its ability to adapt to exercise-induced stress if atherosclerosis or microvascular disease is present?", "Is there a vessel that would increase its blood supply to the heart muscle by dilating during periods of increased cardiac demand?"], "functions": ["Can you identify a vessel that adjusts its diameter in response to increased cardiac workload?", "Can you identify a branching network that supplies blood directly to cardiac tissue?", "Is there evidence of endothelial-mediated vasodilation or metabolic regulation in the vessels supplying the heart?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Is there visible accumulation of fluid within a structure, as seen in hydrocephalus or meningitis?", "Does the image show a structure that appears swollen, which could indicate conditions like cerebral edema or infection?", "Is there evidence of shrinkage or reduced size in a structure that might be associated with aging or neurodegenerative diseases?"], "properties": ["Is there evidence of a region that could contain around 86 billion neurons?", "Can you identify an object that appears pale grayish-pink in color?", "Does the image show a structure whose size could be approximately 15 centimeters in length and 14 centimeters in width?"], "relational": ["Does the image show a structure that is part of the nervous system?", "Can you identify neural tissue or glial cells within any structure present?", "Is there evidence of cranial nerves, such as the optic nerve or other nerves originating from a central structure?"], "contexual_behavior": ["Can you identify a structure that reduces oxygen consumption during anesthesia as neural activity decreases?", "Can you identify a structure that reduces executive function during aging as prefrontal cortex efficiency declines?", "Does the image contain a region where neurotransmitter release, such as serotonin, norepinephrine, or dopamine, might be decreased in depression?"], "functions": ["Can you see regions like the basal ganglia or cerebellum that coordinate voluntary actions?", "Is there a region involved in regulating sleep and circadian rhythms?", "Can you identify a region involved in processing sensory information?"]}}, "basilar skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a fracture involving the base of the skull, particularly in bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Is there a fracture line at the cranial base that appears less than a few millimeters wide?", "Does the image reveal a break limited to the thickness of the cranial base bones, typically only a few millimeters deep?", "Can you see a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Is there a lucent line traversing the base of the skull visible on the image?", "Does the image show an air-fluid level or evidence of pneumocephalus near the base of the skull?", "Can you identify any signs of cerebrospinal fluid leakage in association with a skull base fracture?", "Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Does the image suggest a unilateral fracture at the base of the skull, rather than a bilateral one?", "Is the temporal bone involved in the observed skull base fracture?", "Can you estimate whether the displacement of the fracture at the skull base is minimal, less than 2 millimeters?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?", "Are there air-fluid levels present near the base of the skull, as seen in about 20% to 30% of such fractures?", "On CT imaging, is there a hypodense (lucent) line at the base of the skull relative to the surrounding bone?", "Can you observe bruising patterns such as blue or purple discoloration behind the ear or around the eyes, which may change to yellow-green as they resolve?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Can you identify abnormalities in the anterior, middle, or posterior cranial fossae?", "Is there any indication of injury near the course of cranial nerves like the olfactory, optic, or facial nerves?", "Does the image reveal changes involving foramina such as the foramen magnum or cribriform plate?", "Are there visible alterations adjacent to the inner ear, nasal cavity, or orbit?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?", "Is there evidence of communication between the cranial cavity and spaces such as the subarachnoid space or paranasal sinuses?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Are there signs of disruption in sinuses such as the sphenoid or ethmoid sinus?", "Can you identify exposure or compromise of anatomical pathways like cerebrospinal fluid pathways or the auditory canal?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a disruption in the structural integrity of the skull base that could compromise brain protection?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Can you identify features suggesting a breach between the nasal cavity and cranial cavity, such as a defect in the cribriform plate?", "Does the image reveal any signs that could explain cranial nerve deficits, such as those affecting facial movement, hearing, vision, or swallowing?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?", "Can you see any indications that might increase the risk of infection entering the central nervous system, such as a direct pathway for pathogens?", "Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Are there features present that could facilitate the development of a cerebrospinal fluid leak due to openings in the dura mater or bone?", "Is there any sign of functional impairment, such as altered consciousness, seizures, or focal neurological deficits, that could be explained by a structural abnormality at the skull base?"]}, "no_questions": {"contexual_properties": ["Do you observe abnormal aggregation of a protein in regions affected by protein misfolding disorders or oxidative stress?", "Do you see cytoplasmic accumulation of a protein in areas with impaired protein degradation or cellular stress?", "Can you observe more intense staining in hyperplastic epithelial lesions or in malignant tumors?"], "properties": ["Does the image show a brown staining pattern in epithelial cells that could indicate the presence of a protein encoded by a gene located on chromosome 12q13.13?", "Does the image show a pattern consistent with a protein whose secondary structure is predominantly alpha helix with some random coil regions?", "Can you identify a structure that might contain a type II keratin with an alpha-helical coiled-coil domain?"], "relational": ["Is there evidence of transitional or glandular epithelium in regions such as the respiratory tract or female genital tract?", "Is there a visible epithelial layer in the urinary tract or endometrium that could be positive for a marker not found in stratified squamous or gastrointestinal epithelium?", "Are there epithelial cells present that might co-express cytoskeletal proteins used in diagnostic panels for distinguishing glandular tumors?"], "contexual_behavior": [], "functions": ["Is there a visible feature suggesting the maintenance of cell shape and stability through a resilient filament network?", "Can you identify a filamentous network within the cytoplasm that reinforces the cytoskeleton of epithelial cells?", "Does the image contain cells that could be distinguished by a marker indicative of specific epithelial lineages or differentiation states?"]}}, "obvious hemorrhage": {"yes_questions": {"contexual_properties": ["Does the image show an area where the volume of a blood-like substance appears to be increasing, suggesting ongoing vascular injury or active bleeding?", "Is there a region where a blood-colored material appears darker, possibly indicating exposure to air and oxidation over time?", "Can you identify a location where a blood-like substance appears lighter in color, suggesting dilution by fluids such as saline or plasma?", "Is there evidence of rapid clot formation in a localized area, which could indicate abundant coagulation factors and localized bleeding?", "Does the image show a blood-like substance that remains liquid for an extended period, possibly due to the presence of anticoagulants or a deficiency in clotting factors?", "Can you see visible tissue debris within a blood-colored area, suggesting associated tissue trauma or laceration?", "Is there a region where a blood-like substance appears to be mixed with other fluids, such as cerebrospinal fluid, serous fluid, or exudate?", "Does the blood-colored material appear to be spreading over a large, non-confined area, which may indicate uncontrolled bleeding?", "Is there a noticeable decrease in the amount of a blood-like substance, suggesting that hemostasis or bleeding control has been achieved?", "Can you observe changes in the consistency of a blood-colored area, such as thickening, thinning, or breakdown, possibly due to clotting, dilution, or hemolysis?", "Is there a frothy appearance to a blood-like substance, which could indicate mixing with air, as seen in pulmonary or airway bleeding?", "Does the image show a blood-colored area with a crust or scab on the surface, suggesting air exposure and drying?", "Can you identify regions where a blood-like substance appears to have separated into layers, possibly due to sedimentation and gravity?", "Is there evidence of increased viscosity in a blood-colored area, which may result from clot formation or dehydration?", "Does the image show visible clots within a blood-like substance, indicating coagulation at the bleeding site?", "Is there a blood-colored area that appears to be mixed with pus, suggesting concurrent infection or abscess formation?", "Can you observe a blood-like substance that appears diluted, possibly due to mixing with intravenous or other body fluids?", "Is there a region where the blood-colored material appears to have a foul odor, which could be inferred from signs of bacterial contamination or tissue necrosis?", "Does the image show a blood-like substance with a high red blood cell content, suggesting acute and undiluted bleeding?", "Can you identify changes in the temperature of a blood-colored area, possibly due to environmental exposure or fluctuations in body temperature?"], "properties": ["Does the image show a situation where the volume of blood loss appears to exceed 500 milliliters?", "Can you identify an area with active, visible bleeding from a wound or body opening?", "Is there evidence of rapid blood loss, such as a large pool or stream of liquid blood?", "Does the blood in the image appear bright red, suggesting an arterial source, or dark red, indicating a venous source?", "Can you see blood that is liquid and free-flowing rather than clotted?", "Is there a scenario where the duration of bleeding could be estimated in minutes to hours if left uncontrolled?", "Does the image suggest that the blood present is at body temperature, around 37 degrees Celsius?", "Is there a context where the pH of blood might be within the normal range but could decrease if bleeding continues?", "Can you infer that the oxygen saturation of the blood is likely high unless there are signs of shock?", "Is there a situation where ongoing blood loss could lead to a decrease in hemoglobin concentration below 12 g/dL?"], "relational": ["Does the image show evidence of injury affecting the cardiovascular, musculoskeletal, or integumentary systems?", "Can you identify damage involving the skin, subcutaneous tissue, or blood vessels?", "Is there visible disruption of the epidermis, dermis, or muscle tissue?", "Does the image display signs of trauma on the extremities, scalp, face, or torso?", "Can you see indications of bleeding originating from arteries, veins, or capillaries?", "Is there a visible external wound, laceration, or penetrating injury present?", "Does the image show anatomical barriers such as fascia, periosteum, or skin that might be containing or limiting the spread of blood?", "Are there exposed or compromised structures like blood vessels, nerves, or connective tissue visible?", "Can you observe any connection between the site of bleeding and nearby organs through direct extension, vascular supply, or tissue planes?", "Does the blood appear to traverse multiple tissue layers, such as skin, subcutaneous tissue, and muscle?"], "contexual_behavior": ["Does the image show evidence of a process that could lead to reduced oxygen delivery to tissues, such as hypovolemia or anemia?", "Is there a visible event that might result in impaired blood clotting due to depletion of platelets or clotting factors?", "Can you identify signs that suggest decreased perfusion of vital organs, such as hypotension or shock?", "Does the image depict a situation where immune cell transport could be diminished, potentially leading to impaired host defense?", "Is there evidence of a process that might impair the removal of metabolic waste products, such as renal hypoperfusion or waste accumulation?", "Can you see indications that nutrient delivery to tissues could be compromised, resulting in maldistribution or tissue starvation?", "Does the image suggest a scenario where the body's ability to maintain blood pressure is reduced, possibly leading to vascular collapse?", "Is there visual evidence of impaired thermoregulation, such as signs of hypothermia or circulatory failure?", "Can you identify a situation where hormone transport to target tissues might be decreased, leading to endocrine disruption?", "Does the image suggest a process that could weaken the body's defense against infection, such as immunosuppression or hypoproteinemia?", "Is there evidence that the blood's capacity to buffer pH is reduced, potentially resulting in acidosis or metabolic imbalance?", "Can you see signs that the normal inflammatory response to injury might be altered, such as impaired healing or mediator deficiency?", "Does the image indicate a shift in blood flow away from peripheral tissues, suggesting peripheral vasoconstriction or tissue ischemia?", "Is there evidence that removal of carbon dioxide from tissues could be decreased, leading to hypercapnia or impaired gas exchange?", "Can you identify a situation where the effectiveness of drug delivery via the bloodstream might be reduced due to impaired pharmacokinetics?"], "functions": ["Does the image show evidence of rapid blood loss that could result in decreased tissue oxygenation?", "Is there a visible sign of reduced blood volume that might impair cardiac output?", "Can you identify an area where vascular injury may have exposed sites for platelet activation or clotting?", "Does the image suggest decreased oxygen delivery to tissues, such as signs of anemia or hypoperfusion?", "Are there visual cues indicating the activation of compensatory mechanisms like vasoconstriction or tachycardia?", "Is there evidence of a drop in blood pressure, potentially progressing to hypotension, visible in the image?", "Can you see signs of impaired perfusion or reduced blood flow to vital organs?", "Does the image suggest the development of shock due to inadequate tissue perfusion or cellular dysfunction?", "Are there indications that the coagulation cascade has been activated to form clots and limit further blood loss?", "Is there visual evidence of compromised organ function, such as hypoxia or early signs of organ failure?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a region with moderate amounts of elastic fibers providing some elasticity?", "Does the image show an area where fibroblasts or occasional immune cells might be present?", "Is there evidence of abundant collagen fibers in the outermost layer?"], "relational": ["Is there a visible layer that is adjacent to periadrenal adipose tissue or connective tissue?", "Does the image show a layer that connects to both the adrenal cortex and adrenal medulla via a capsule?", "Can you identify a region that is external to and encloses the adrenal gland?"], "contexual_behavior": ["Does the image show reduced capacity for repair or regeneration in a capsule-like area, possibly due to cellular depletion or impaired regenerative processes?", "Is there evidence of increased permeability or tissue remodeling in an area that could be affected by inflammation and cytokine activity?", "Does the image suggest increased extracellular matrix production, such as enhanced fibroblast activity, in response to chronic stress?"], "functions": ["Does the image contain a region that acts as a selective barrier between the adrenal gland and its surrounding tissues?", "Is there a structure visible that serves as a supportive barrier around the adrenal gland?", "Does the image show a fibrous layer that provides protection to the adrenal gland?"]}}}
[ { "answer": "skull cap with obvious metastatic lesions primary in pancreas", "extracted_concepts": [ "obvious metastatic lesions", "skull cap", "primary in pancreas" ], "question": "what does this image show?" }, { "answer": "with obvious metastatic lesions primary in pancreas", "extracted_concepts": [ "obvious metastatic lesions", "skull cap", "primary in pancreas", "pancreas" ], "question": "how does this image show skull cap?" }, { "answer": "yes", "extracted_concepts": [ "metastatic lesions", "skull cap", "primary in pancreas" ], "question": "does this image show skull cap with obvious metastatic lesions primary in pancreas?" }, { "answer": "no", "extracted_concepts": [ "rheumatoid arthritis", "metastatic lesions", "skull cap", "pancreas" ], "question": "does rheumatoid arthritis show skull cap with obvious metastatic lesions primary in pancreas?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "cytomegalovirus" ], "question": "is cytomegalovirus present?" }, { "answer": "metastatic pancreas carcinoma", "extracted_concepts": [ "metastatic pancreas carcinoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "pancreas", "metastatic pancreas carcinoma" ], "question": "is metastatic pancreas carcinoma present?" }, { "answer": "no", "extracted_concepts": [ "eye" ], "question": "is eye present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "metastatic pancreas carcinoma", "extracted_concepts": [ "metastatic pancreas carcinoma" ], "question": "what is present?" } ]	["metastatic lesions", "primary in pancreas", "bone", "metastatic pancreas carcinoma", "rheumatoid arthritis", "obvious metastatic lesions", "pancreas", "cytomegalovirus", "calvarium", "skull cap", "eye"]	{"metastatic lesions": {"yes_questions": {"contexual_properties": ["Does the image show any abnormal areas that have increased in size, suggesting tumor growth or disease progression?", "Can you identify any regions that appear to have shrunk, possibly indicating a response to therapy such as chemotherapy or radiation?", "Are there any lesions that have changed shape, which could reflect tumor evolution, necrosis, or the effects of treatment?", "Does the image reveal an increased number of abnormal foci, suggesting tumor dissemination or metastatic spread?", "Can you observe any changes in color or imaging appearance of lesions that might be due to alterations in vascularity, hemorrhage, or necrosis?", "Are there any areas that appear calcified, which could indicate dystrophic calcification in treated or chronic disease?", "Do you see evidence of necrosis within any lesions, such as regions of low density or central breakdown, possibly due to ischemia or therapy?", "Is there any sign of hemorrhage within abnormal regions, such as hyperdense or irregular areas, which might result from vascular fragility or rapid growth?", "Can you detect changes in the density of lesions, potentially due to variations in cellularity, necrosis, hemorrhage, or cystic transformation?", "Are there any cystic-appearing regions within abnormal foci, suggesting central necrosis or liquefaction?", "Do any lesions show increased vascularity, which could be a sign of angiogenesis associated with tumor growth?", "Can you observe changes in the margins of abnormal areas, such as irregularity or smoothing, which might indicate infiltration, regression, or therapy response?", "Are there lesions that appear more heterogeneous, with mixed areas of necrosis, hemorrhage, calcification, or cystic change?", "Is there evidence of edema surrounding any abnormal regions, possibly due to local inflammation or disruption of the blood-brain barrier?", "Do any lesions demonstrate increased metabolic activity, such as high uptake on PET imaging, which could indicate aggressive or highly proliferative tumor cells?", "Can you identify areas that have lost contrast enhancement, possibly due to necrosis, reduced vascularity, or effective therapy?", "Are there any lesions with central cavitation, suggesting the formation of a cavity due to tumor necrosis?", "Do you see changes in the composition of abnormal areas, such as alterations in cellularity, stroma, necrosis, or hemorrhage?", "Are there regions that appear more solid, which could be due to increased tumor cell proliferation or resolution of cystic or necrotic components?", "Is there evidence of abnormal tissue invading surrounding normal structures, indicating local infiltration by tumor cells?"], "properties": ["Does the image show any structures that are round, ovoid, or have irregular contours?", "Can you identify multiple areas that differ in size, ranging from a few millimeters to several centimeters?", "Are there regions in the image that appear pale, gray-white, or tan compared to surrounding tissue?", "Is there evidence of areas with increased density or, alternatively, regions that appear hypodense, possibly due to necrosis?", "Can you see any structures with well-defined or infiltrative margins?", "Are there multiple distinct regions present, rather than a single abnormal area?", "Does the image reveal areas with increased vascularity, such as prominent blood vessels or signs of angiogenesis?", "Are there regions that suggest central necrosis, especially within larger or rapidly growing areas?", "Is there any indication of calcification within abnormal regions, even though it is rare?", "Do any of the visible structures seem to have a rapid growth pattern compared to benign-appearing areas?", "Can you identify regions that might contain a high proportion of malignant or inflammatory cells based on their appearance?", "Are there areas that could correspond to increased metabolic activity, such as regions with high FDG uptake on PET imaging?", "Does the image suggest that certain areas have a higher stiffness than surrounding normal tissue, as might be seen on elastography?", "Can you see any features that could indicate a high nuclear-to-cytoplasmic ratio in the cells of a particular region?", "Are there regions that might have elevated water content, such as those appearing edematous or highly cellular?", "Is there any evidence of low lipid content in abnormal areas, except where adipocytic differentiation might be present?", "Do any regions appear to have a slightly more acidic environment than the surrounding tissue, as might be inferred from imaging or staining?", "Are there visual cues that could suggest the presence of tumor markers such as cytokeratins or vimentin in certain areas?", "Can you identify regions where genetic alterations, such as oncogene or tumor suppressor mutations, might be suspected based on their appearance or behavior?"], "relational": ["Does the image show abnormal growths within epithelial, connective, nervous, or muscle tissue?", "Can you identify any unusual structures in organs such as the liver, lungs, bones, brain, or lymph nodes?", "Is there evidence of secondary tumors that may have originated from a primary malignancy elsewhere?", "Does the image suggest the involvement of the circulatory or lymphatic systems in the spread of abnormal cells?", "Are there visible changes along blood vessels, lymphatic vessels, or within body cavities that could indicate the distribution of malignant cells?", "Can you see any lesions located in regions like the spine, regional lymph nodes, or brain?", "Is there a structure containing cells that appear malignant, along with stromal or immune cells?", "Are there abnormal masses adjacent to normal parenchyma, blood vessels, nerves, or connective tissue?", "Does the image show enlarged or altered regional lymph nodes or lymphatic capillaries?", "Are there signs of involvement of veins, capillaries, arteries, or venules in the spread of abnormal tissue?"], "contexual_behavior": ["Does the image show any abnormal structures invading surrounding tissues, suggesting active extracellular matrix remodeling?", "Is there evidence of tissue regions that might be evading immune surveillance, such as areas with altered antigen presentation or increased immune checkpoint expression?", "Can you identify lesions exhibiting enhanced blood vessel formation, possibly due to hypoxic conditions and pro-angiogenic signaling?", "Are there regions where abnormal cell clusters appear less proliferative, potentially indicating a response to chemotherapy-induced cell cycle arrest or apoptosis?", "Do you observe any areas that might be shifting their metabolic activity, such as increased glycolysis or autophagy, possibly due to nutrient deprivation?", "Is there evidence of abnormal growths failing to establish secondary expansion, which could be due to insufficient vascular support?", "Can you see any features suggesting increased resistance to cell death, such as persistence of abnormal cells despite apparent treatment effects?", "Are there regions where the spread of abnormal cells appears reduced, possibly as a result of effective targeted therapy?", "Does the image reveal abnormal structures with enhanced migratory characteristics, potentially in response to inflammatory signals?", "Is there evidence of abnormal cell clusters failing to colonize distant tissues, which could be due to immune-mediated clearance in an immunocompetent environment?", "Can you identify regions where increased secretion of proteolytic enzymes may be facilitating tissue invasion and extracellular matrix degradation?", "Are there abnormal growths whose proliferation or size appears altered, possibly in response to hormonal changes?", "Do you observe any abnormal vascular patterns suggesting resistance to anti-angiogenic factors or activation of alternative angiogenic pathways?", "Is there evidence of widespread dissemination of abnormal cells, potentially promoted by systemic inflammation?", "Can you see regions where abnormal cell survival appears compromised, possibly due to loss of stromal support or microenvironmental factors?", "Are there features indicating behavioral adaptation of abnormal cells following radiation therapy, such as changes in morphology or distribution?", "Does the image suggest increased persistence or proliferation of abnormal cells in the context of immunosuppression?", "Is there a reduction in the spread of abnormal cells that could be associated with the removal of a primary tumor source?", "Can you identify areas where abnormal cells may be relying on anaerobic glycolysis and producing excess lactate, possibly due to hypoxic microenvironments?", "Are there features suggesting increased resistance to oxidative stress in circulating abnormal cells, such as survival in vascular spaces?"], "functions": ["Does the image show evidence of secondary tumor sites that could indicate disease advancement?", "Can you identify structures that suggest the spread of cancer to distant organs?", "Is there visual disruption of normal tissue architecture that might be due to replacement of healthy cells?", "Does the image reveal any areas where organ function could be compromised by abnormal growths?", "Are there features that might indicate interference with physiological processes in a specific organ?", "Can you see signs of immune cell activity modulation or evasion within abnormal tissue regions?", "Is there evidence of local inflammation or changes in the tissue microenvironment near abnormal masses?", "Do you observe patterns suggesting new blood vessel formation supporting abnormal tissue growth?", "Are there visual cues that could indicate systemic effects, such as changes in organ appearance consistent with paraneoplastic syndromes?", "Can you identify regions where altered metabolic activity might be supporting the survival of abnormal cells?", "Does the image show abnormalities that could explain clinical symptoms such as pain or organ dysfunction?"]}, "no_questions": {"contexual_properties": ["Is there any displacement of structures that might be caused by mass effect from a tumor, hemorrhage, or edema?", "Does the image show abnormal fluid accumulation that might indicate hydrocephalus or a cystic malformation?", "Is there evidence of hemorrhage that could be associated with trauma, vascular malformation, or hypertensive crisis?"], "properties": ["Does the image show a space containing neural tissue, meninges, cerebrospinal fluid, and blood vessels?", "Can you identify a space with a surface area estimated between 60 and 80 square centimeters?", "Does the image include an area where the surrounding bone thickness is approximately 4 to 8 millimeters?"], "relational": ["Does the image display foramina such as the foramen magnum, jugular foramen, internal acoustic meatus, or hypoglossal canal in a particular area?", "Is there a space containing major brain structures such as the cerebellum, pons, or medulla oblongata?", "Does the image show vascular structures such as the vertebral arteries, basilar artery, or dural venous sinuses in a specific area?"], "contexual_behavior": ["Can you see signs of infection, inflammation, or abscess formation that might alter neural connectivity in this region?", "Is there evidence of acute hemorrhage affecting the brainstem or surrounding structures, potentially leading to autonomic dysfunction?", "Is there evidence of cerebrospinal fluid outflow obstruction at the fourth ventricle or aqueduct, indicating impaired pressure buffering?"], "functions": ["Can you identify a region that enables movement coordination by containing the cerebellum?", "Is there a region contributing to reflex control by housing neural circuits involved in cranial and spinal reflexes?", "Does the image include a space involved in balance and posture through processing vestibular and proprioceptive information?"]}}, "primary in pancreas": {"yes_questions": {"contexual_properties": ["Is there a structure within the pancreas that appears enlarged, suggesting tumor progression or malignancy?", "Can you identify an area in the pancreas that has decreased in size, possibly indicating a response to therapy or regression?", "Does the image show a pancreatic lesion with irregular or changing shape, which might suggest invasion into surrounding tissues or necrosis?", "Is there a region in the pancreas that appears denser than surrounding tissue, consistent with increased cellularity or fibrosis?", "Can you see a less dense area within a pancreatic mass, potentially due to necrosis or cystic degeneration?", "Is there a part of the pancreas with altered coloration, possibly due to hemorrhage, necrosis, or changes in vascularity?", "Does the image reveal a pancreatic lesion with abnormal cellular composition, such as dedifferentiation or infiltration by inflammatory cells?", "Is there evidence of necrotic regions within a pancreatic mass, which could result from ischemia or effects of therapy?", "Can you identify cystic changes in a pancreatic lesion, suggesting cystic degeneration or mucinous transformation?", "Is there a region in the pancreas with increased vascularity, possibly indicating angiogenesis or tumor growth?", "Do you observe calcifications within a pancreatic mass, which might result from chronic inflammation or tumor necrosis?", "Is there an area in the pancreas that appears metabolically active, consistent with rapid tumor proliferation?", "Can you see abnormal tissue architecture in the pancreas, suggesting dysplasia or neoplastic transformation?", "Is there a pancreatic lesion that appears encapsulated, possibly surrounded by a fibrous capsule or stromal reaction?", "Does the image show hemorrhagic changes in a pancreatic mass, which could be due to vascular invasion or trauma?", "Is there a region in the pancreas that appears stiffer or more fibrotic, consistent with fibrosis or a desmoplastic reaction?", "Can you identify edema within or around a pancreatic lesion, possibly due to inflammation or increased vascular permeability?", "Is there evidence of fibrotic tissue development in a pancreatic mass, which might result from chronic injury or desmoplastic reaction?", "Do you observe increased mitotic figures in a pancreatic lesion, suggesting active cell division or high-grade malignancy?", "Is there a change in the boundary definition of a pancreatic mass, such as infiltration into adjacent tissues or encapsulation?"], "properties": ["Is there a structure in the pancreas that measures between 2 and 5 centimeters in diameter?", "Can you identify a mass in the pancreas that appears irregular or nodular in shape?", "Does the image show a lesion in the pancreas with a whitish to yellow-tan coloration?", "Is there evidence of a firm or hard mass within the pancreas?", "Can you see a pancreatic structure that appears denser than the surrounding normal tissue?", "Is there a region in the pancreas that could correspond to a mass weighing between 20 and 100 grams?", "Does the image reveal a pancreatic lesion with low to moderate vascularity or hypovascular characteristics?", "Can you identify an area in the pancreas that might contain focal calcifications?", "Is there a mass in the pancreas that could be associated with moderate to rapid growth?", "Does the image show a pancreatic lesion with signs of necrosis affecting 10% to 40% of its area?", "Is there a region in the pancreas that could be composed of malignant epithelial cells, stromal cells, and infiltrating immune cells?", "Can you detect a pancreatic mass that might be moderate to poorly differentiated histologically?", "Is there a structure in the pancreas that could have a high nuclear-cytoplasmic ratio in its cells?", "Does the image show a pancreatic lesion that might have an elevated mitotic index?", "Can you identify a mass in the pancreas that could have a Ki-67 proliferation index between 10% and 40%?", "Is there a pancreatic region that might exhibit low lipid content and relatively high protein content?", "Does the image reveal a lesion in the pancreas that could have a slightly acidic microenvironment (pH 6.8 to 7.0)?"], "relational": ["Does the image show a structure that is part of both the digestive and endocrine systems?", "Can you identify an organ located in the abdominal cavity, specifically within the retroperitoneal space or epigastric region?", "Is there a structure situated near the duodenum, stomach, spleen, or gallbladder?", "Does the image contain a structure connected to ducts such as the main pancreatic duct, accessory pancreatic duct, or common bile duct?", "Can you see evidence of blood vessels like the splenic artery or pancreaticoduodenal arteries supplying a particular organ?", "Is there an object composed of distinct regions such as a head, neck, body, tail, or uncinate process?", "Does the image show a structure containing specialized cells like acinar cells, ductal cells, or islet cells (including alpha, beta, delta, or PP cells)?", "Can you identify a structure that is anatomically or functionally connected to the duodenum via a duct or the ampulla of Vater?", "Is there evidence of secretions being transported by a main or accessory duct within the image?", "Does the image show lymphatic drainage involving pancreaticosplenic or pancreaticoduodenal lymph nodes?"], "contexual_behavior": ["Is there a structure in the image that increases hormone output, such as insulin, after carbohydrate ingestion?", "Can you identify an organ that decreases digestive enzyme production in the context of chronic pancreatitis or severe malnutrition?", "Does the image show a structure whose failure to regulate blood glucose could be linked to diabetes mellitus?", "Is there evidence of inflammation or cellular injury that could impair the function of acinar and islet cells?", "Can you see an organ that would increase glucagon release during fasting to maintain glucose levels?", "Is there a structure whose bicarbonate secretion might be reduced due to duct obstruction, as seen in cystic fibrosis?", "Does the image contain an organ that alters hormone output by increasing insulin and suppressing glucagon in response to high blood sugar?", "Can you identify a structure that might show decreased enzyme secretion after chronic alcohol use due to acinar cell damage?", "Is there evidence of beta cell loss that could result in insulin deficiency, as in type 1 diabetes?", "Does the image show an organ that increases digestive enzyme release after a high-fat meal to aid in lipid digestion?", "Can you see a structure whose reduced bicarbonate secretion could fail to neutralize stomach acid, contributing to duodenal ulcers?", "Is there an organ that increases insulin output during pregnancy to meet higher metabolic demands?", "Does the image contain a structure that could show reduced hormone and enzyme production following autoimmune attack?", "Is there evidence of altered hormone secretion, such as increased glucagon and decreased insulin, during acute stress?", "Can you identify a structure that might exhibit reduced hormone secretion due to decreased islet cell function in aging?"], "functions": ["Does the image show a structure responsible for both hormone secretion and digestive enzyme production?", "Can you identify cells that regulate blood glucose by releasing insulin or glucagon?", "Is there evidence of specialized cells, such as those that release glucagon or insulin, present in the image?", "Does the image contain features associated with the production of digestive enzymes like proteases, lipases, or amylases?", "Can you see structures involved in nutrient breakdown through enzyme secretion into the small intestine?", "Is there a region that participates in metabolic regulation by modulating hormone secretion?", "Does the image show evidence of cells that synthesize and release insulin in response to high blood sugar?", "Can you identify areas where homeostasis is maintained by balancing hormone and enzyme levels?", "Is there a structure involved in raising blood glucose levels during hypoglycemia by releasing glucagon?", "Does the image display cells that adjust hormone and enzyme secretion in response to changing nutrient levels?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show a thin layer, approximately 20 to 100 micrometers thick, covering an organ?", "Can you identify a tissue with low to moderate elastic fiber content, suggesting limited elasticity?", "Can you identify a structure with a smooth and slippery surface texture?"], "relational": ["Can you identify a structure that forms the outermost layer of the stomach, small intestine, large intestine, or uterus?", "Is there a structure in the image that covers intestinal loops, the stomach, or the uterus?", "Does the image display a boundary separating an internal organ from a cavity such as the peritoneal cavity?"], "contexual_behavior": ["Is there an accumulation of excess fluid that could be associated with heart or lung failure due to impaired fluid resorption?", "Is there a region where increased permeability and immune cell infiltration might be seen during infection?", "Does the image suggest functional changes or chronic inflammation that could be associated with autoimmune disorders affecting serous membranes?"], "functions": ["Is there a thin membrane visible that provides a protective covering for internal organs?", "Is there a membrane visible that separates different body cavities, such as the peritoneum, pleura, or pericardium?", "Is there a structure present that could help contain infections by limiting the spread of pathogens within a body cavity?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a near-complete absence of skull bones in the cranial region?", "Is there visible neural tissue that appears dark red to purple and has a friable, gelatinous texture?", "Is there evidence of microcephaly or a head circumference far below the expected range for gestational age?"], "relational": ["Is there a region of the head where the scalp appears missing or abnormal?", "Does the image suggest a disruption in neural tube closure, particularly at the anterior end?", "Is there evidence of absent or malformed diencephalon in the cranial area?"], "contexual_behavior": ["Can you observe signs of failed sensory processing in the fetus, possibly due to missing sensory relay centers in the brain?", "Does the image suggest abnormal regulation of heart rate or respiration that could result from a malformed or absent brainstem?", "Is there evidence of disrupted signaling between the brain and other organs, as might occur if neural pathways for inter-organ communication are absent?"], "functions": ["Is there a complete lack of consciousness or cognitive function, as might be expected if the cerebral cortex is not developed?", "Does the image indicate disruption of hormonal regulation or homeostasis, such as impaired hypothalamic or pituitary function?", "Is there evidence of profound sensory and motor deficits due to missing essential brain structures?"]}}, "metastatic pancreas carcinoma": {"yes_questions": {"contexual_properties": ["Does the image show a mass that appears to have increased in size, suggesting disease progression or uncontrolled cell proliferation?", "Is there evidence of a lesion that has decreased in size, which could indicate a response to chemotherapy or other therapies?", "Can you identify a region with variable density, possibly due to necrosis, fibrosis, or effects of treatment?", "Is there a mass with areas that appear necrotic, which might result from hypoxia, ischemia, or cytotoxic therapy?", "Does the image reveal a lesion with increased vascularity, consistent with angiogenesis in response to hypoxic conditions?", "Can you see any calcified regions within a mass, suggesting chronicity or the effects of therapy?", "Is there evidence of heterogeneity within a lesion, such as regions of necrosis, hemorrhage, or variable cellularity?", "Does the image show cystic regions within a mass, possibly due to degeneration or necrosis?", "Are there areas of altered color within a lesion, which could be due to hemorrhage, necrosis, or vascular changes?", "Can you identify a mass that appears firmer or denser, potentially due to fibrosis or a desmoplastic stromal reaction?", "Is there a lesion with increased mitotic figures, suggesting rapid cell division and tumor aggressiveness?", "Does the image show a mass with loss of glandular structure, indicating poor differentiation or anaplasia?", "Are there regions within a lesion that appear mucinous, consistent with mucin accumulation in certain tumor subtypes?", "Can you see hemorrhagic areas within a mass, possibly due to vascular fragility or rapid tumor growth?", "Is there evidence of increased metabolic activity in a lesion, such as high FDG uptake on PET imaging?", "Does the mass have irregular borders, which could indicate invasion into surrounding tissues and loss of encapsulation?", "Can you identify a lesion with increased stromal content, suggesting a desmoplastic reaction or tumor-stroma interaction?", "Is there visual evidence of altered protein expression within a mass, possibly due to genetic or epigenetic changes or therapy response?"], "properties": ["Does the image show a mass that appears irregular or infiltrative in shape?", "Is there a lesion present that measures between 2 and over 10 centimeters in size?", "Can you identify a tissue mass that might weigh more than 50 grams?", "Is there a structure with a gray-white or yellowish color, possibly with areas of necrosis?", "Does the image contain a mass composed of malignant epithelial cells along with fibroblasts, immune cells, and endothelial cells?", "Can you see evidence of a high mitotic index, such as numerous mitotic figures in a given area?", "Is there a population of cells with an increased nuclear-to-cytoplasmic ratio due to enlarged nuclei?", "Does the image show features consistent with a high-grade (Grade 3) tumor?", "Are the cells in the lesion poorly differentiated, lacking normal glandular structures?", "Is there evidence of a proliferation index above 20%, such as a high number of Ki-67 positive cells?", "Can you identify areas with moderate to high mucin content within the tissue?", "Does the image show cells with aneuploid DNA content, as might be inferred from nuclear irregularity?", "Is there increased vascular density in the tissue compared to normal pancreas?", "Can you see signs that would suggest elevated CA 19-9 expression in the lesion?", "Are there regions of necrosis comprising between 10% and 50% of the mass?", "Is the frequency of glandular structures low within the lesion?", "Does the stroma appear prominent relative to the tumor cells, suggesting a high stroma-to-tumor ratio?", "Are there more than two mitotic figures per high power field visible in the tissue?", "Is there a prominent desmoplastic stroma present in the lesion?", "Do the nuclei of the cells display coarse and irregular chromatin patterns?"], "relational": ["Does the image show evidence of a disease process primarily affecting the digestive system?", "Is there a visible abnormality involving the pancreas?", "Can you identify lesions or masses in organs such as the liver, lungs, or peritoneum?", "Does the image reveal invasion into the liver parenchyma or peritoneal lining?", "Are there signs of involvement of lymphatic tissue or regional lymph nodes near the pancreas?", "Can you see enlarged peripancreatic, celiac, or superior mesenteric lymph nodes?", "Is there any indication of abnormality in blood vessels such as the portal vein, splenic vein, or superior mesenteric vein?", "Does the image show changes in the duodenum, spleen, or stomach that could be related to metastatic spread?", "Are there abnormalities present in the abdominal cavity, retroperitoneum, or thoracic cavity?", "Can you identify lesions within the peritoneal or pleural cavities?", "Is there evidence of impaired pancreatic function or disruption of other digestive organs?"], "contexual_behavior": ["Is there evidence of a tumor that shows features of invasion into distant organs, possibly associated with increased matrix metalloproteinase activity?", "Can you identify a neoplastic lesion that might display reduced responsiveness to chemotherapy, such as signs of drug resistance or increased efflux transporter expression?", "Does the image suggest a tumor with accelerated metastatic spread, potentially under hypoxic conditions or with features of hypoxia-inducible factor activation?", "Is there a neoplastic area that appears to have altered metabolic activity, such as increased glycolysis or autophagy, possibly in response to nutrient deprivation?", "Can you see a tumor that may be suppressing immune surveillance, for example by expressing immune checkpoint molecules or showing signs of immunosuppressive cytokine activity?", "Is there evidence of increased angiogenesis within a tumor, such as abundant new blood vessels or features suggesting upregulation of pro-angiogenic factors?", "Does the lesion appear to resist cell death, potentially through anti-apoptotic signaling or in the presence of growth factors?", "Can you identify a tumor that might be resistant to targeted therapies, possibly due to secondary mutations or activation of alternative signaling pathways?", "Is there evidence of chronic inflammation in the tumor microenvironment, such as activation of NF-\u03baB or STAT3 pathways?", "Does the image suggest a reduction in metastatic potential, possibly following immunotherapy and enhanced immune-mediated tumor cell destruction?", "Can you see signs of extracellular matrix degradation near a tumor, such as increased enzyme activity or tissue breakdown associated with invasion and metastasis?", "Is there a neoplastic region with altered proliferation rates, possibly influenced by hormonal changes or hormone receptor signaling?", "Does the image show reduced invasiveness of a tumor following surgical intervention, such as removal of the primary mass or disruption of metastatic niches?", "Is there evidence of advanced disease with increased immune evasion, such as upregulation of checkpoint molecules or decreased antigen presentation?", "Can you identify changes in metastatic pattern or tumor adaptation to different organ microenvironments, possibly influenced by local stromal or vascular factors?", "Does the tumor appear to have reduced growth rate, potentially as a result of anti-angiogenic therapy and decreased blood supply?", "Is there evidence of metabolic flexibility in a tumor, such as switching between oxidative phosphorylation and glycolysis under systemic stress?", "Can you see alterations in tumor behavior or cell adhesion, possibly due to changes in stromal cell interactions or adhesion molecule expression?", "Is there a neoplastic lesion with increased drug efflux activity, such as upregulation of ATP-binding cassette transporters under chemotherapeutic pressure?", "Does the image suggest reduced metastatic spread after radiation therapy, possibly due to DNA damage or enhanced immune-mediated tumor cell killing?"], "functions": ["Does the image show evidence of a lesion that invades surrounding tissues or adjacent structures?", "Can you identify a mass that appears to have spread beyond its site of origin to distant organs?", "Is there a structure that could be causing destruction of both exocrine and endocrine tissue, potentially leading to digestive enzyme deficiency or altered glucose regulation?", "Does the image contain a mass that might be responsible for metabolic imbalances such as insulin deficiency or hyperglycemia?", "Can you see features suggesting new blood vessel formation supporting abnormal tissue growth?", "Is there evidence of tissue that appears resistant to cell death, such as areas with persistent abnormal cells despite surrounding damage?", "Does the image reveal signs of impaired nutrient absorption or digestive dysfunction, such as reduced pancreatic tissue or obstruction of the gastrointestinal tract?", "Can you identify a lesion that might be associated with systemic effects like muscle or fat wasting?", "Is there visual evidence of a dense fibrotic stroma or altered tissue architecture consistent with desmoplasia?", "Does the image suggest the presence of a mass that could be modifying the local immune environment, such as by reducing immune cell infiltration?", "Can you see a tumor that might be associated with abnormal signaling pathways, such as those involving KRAS, TGF-\u03b2, or PI3K/AKT?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see a vessel that delivers blood to pulmonary alveoli or lung parenchyma?", "Is there a vessel supplying blood to lobar or bronchopulmonary segments of the lung?", "Can you identify a structure adjacent to bronchi, pulmonary veins, or lung parenchyma?"], "contexual_behavior": ["Is there a structure that could dilate during chronic hypoxia or after prolonged exposure to low oxygen?", "Can you identify a vessel that would show decreased perfusion after a vascular blockage such as a pulmonary embolism?", "Is there a vascular structure that could exhibit increased permeability and altered tone during acute respiratory distress syndrome?"], "functions": ["Can you identify a structure that contributes to maintaining pulmonary blood pressure by modulating vessel tone?", "Does the image show a vessel that regulates blood flow within the lungs by adjusting vascular resistance?", "Is there evidence of a vessel that branches extensively to ensure even distribution of blood to different lung regions?"]}}, "rheumatoid arthritis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of joint swelling affecting between 4 and 10 joints?", "Can you identify signs of tenderness in 6 to 12 joints?", "Is there visible morning stiffness that appears to last longer than 60 minutes?", "Does the image display subcutaneous nodules in approximately 20 to 30% of the individuals shown?", "Are there radiographic features indicating mild to moderate joint erosions, with scores that might fall between 10 and 50 on the Sharp/van der Heijde scale?", "Can you observe any extra-articular manifestations present in about 40% of the depicted cases?", "Is there visual evidence suggesting a disease duration spanning 10 to 20 years?", "Does the image suggest the presence of anemia, with hemoglobin levels likely between 10 and 12 g/dL?", "Are there indications of elevated synovial fluid white blood cell counts, possibly ranging from 5,000 to 50,000 cells/\u03bcL?", "Can you infer that the average age of onset for the condition in the individuals shown is between 30 and 60 years?", "Is there evidence suggesting moderate to high disease activity, with a disease activity score (DAS28) likely between 3.2 and 5.1?"], "relational": ["Does the image show evidence of a condition affecting both the musculoskeletal and immune systems?", "Can you identify abnormalities in joints such as those of the hands, wrists, feet, or knees?", "Is there visible damage to structures like the synovial membrane, cartilage, ligaments, or bone within a joint?", "Does the image display chronic inflammation of the tissue lining a joint cavity?", "Are there signs of connective tissue involvement, such as changes in the synovium, tendons, or ligaments?", "Can you see structural alterations in bones such as the phalanges, metacarpals, or carpal bones?", "Is there evidence of joint deformity or bone erosions in the regions commonly affected by autoimmune processes?", "Does the image reveal features like synovial hyperplasia or cartilage erosion within a joint?", "Are there indications of an autoimmune process targeting joint tissues?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Does the image show staining patterns that are more intense in areas where cellular activity or antigen expression is increased?", "Does the image show variability in staining intensity that could be due to physiological or pathological changes in antigen expression?", "Are there increased numbers of stained cells in regions suggestive of cellular proliferation, inflammation, or exposure to a stimulus?"], "properties": ["Is there visible use of chromogens like DAB, AEC, Fast Red, or VIP in the staining?", "Does the image suggest the presence of tissue sections with a thickness in the range of 3 to 5 micrometers?", "Does the image show evidence of staining for markers such as CD3, Ki-67, HER2, p53, or cytokeratin?"], "relational": ["Are there patterns indicating protein expression within specific anatomical compartments, such as the basal layer or lamina propria?", "Does the image contain anatomical regions like the cerebral cortex, lymph nodes, or gastrointestinal mucosa with distinct staining?", "Can you identify features that suggest the sample is from the nervous, immune, digestive, or integumentary system?"], "contexual_behavior": ["Are there areas where non-specific staining suggests a decline in specificity, possibly due to cross-reactive proteins?", "Can you observe a loss of staining in regions where cells appear necrotic or structurally degraded?", "Does the expression pattern of specific markers appear altered in areas affected by disease progression?"], "functions": ["Can you see labeled areas that might correspond to abnormal cell markers or atypical protein expression?", "Is there staining that could suggest the identification of infectious agents by targeting pathogen-specific antigens?", "Does the image provide visual cues that could be used to assess changes in biomarker expression, potentially reflecting treatment response?"]}}, "obvious metastatic lesions": {"yes_questions": {"contexual_properties": ["Does the image show any areas that have increased in size, suggesting tumor growth or disease progression?", "Can you identify regions that have decreased in size, possibly indicating a response to therapy or regression?", "Are there any structures that have changed color, which could be due to hemorrhage, necrosis, or altered vascularity?", "Is there evidence of an increased number of abnormal foci, suggesting metastatic spread or accelerated dissemination?", "Do any lesions appear less distinct, possibly due to infiltration into surrounding tissue or the presence of edema?", "Can you see areas showing necrosis, which might result from ischemia or cytotoxic therapy?", "Are there regions that appear calcified, potentially reflecting dystrophic calcification or post-therapy changes?", "Do any lesions appear hemorrhagic, possibly due to vessel rupture or trauma?", "Is there a visible change in density within any lesion, which could be related to necrosis, hemorrhage, fibrosis, or therapy response?", "Can you identify lesions with irregular borders, which may indicate tissue invasion or rapid growth?", "Are there any cystic-appearing areas, suggesting central necrosis or cystic degeneration?", "Do you observe increased vascularity in any lesion, possibly due to angiogenesis or tumor progression?", "Is there a change in texture of any lesion, such as areas that appear fibrotic, necrotic, or cystic?", "Are there regions that seem firmer, which could be due to increased fibrous tissue or a desmoplastic reaction?", "Do any lesions appear softer, possibly as a result of central necrosis or cystic change?", "Is there evidence of increased uptake on imaging in any area, suggesting elevated metabolic activity or hypervascularity?", "Can you see lesions that have shrunk following interventions such as chemotherapy, radiotherapy, or targeted therapy?", "Are there any regions with central cavitation, which might result from tissue breakdown due to necrosis?", "Do you observe edema around any lesion, possibly indicating local inflammation or increased vascular permeability?", "Is there evidence of changes in lesion composition, such as necrosis, fibrosis, calcification, or cystic transformation?"], "properties": ["Does the image show any structures measuring between 1 and 10 or more centimeters in diameter?", "Are there any round, oval, or irregularly shaped masses visible?", "Can you identify areas that appear white, gray, or tan compared to the surrounding tissue?", "Is there a region that appears denser or less dense than adjacent tissue, or shows a mix of densities?", "Does the image contain multiple masses, ranging from a few to dozens in number?", "Are there visible areas that might be composed predominantly of malignant cells, possibly with stromal or inflammatory components?", "Can you see any masses that appear firm or hard, or possibly softer if necrosis is present?", "Is there evidence of rapid cell proliferation, such as a high mitotic index, in any of the visible structures?", "Are there regions with increased or abnormal blood vessel patterns indicating higher vascularity?", "Do any of the masses appear to be growing more rapidly than surrounding benign-appearing tissue?", "Is there evidence of moderate to high necrosis within any of the visible lesions?", "Are there masses with well-defined, irregular, or infiltrative margins?", "On MRI images, do any lesions show heterogeneous signal intensity, being hypointense on T1 and hyperintense on T2 sequences?", "On PET imaging, is there a region with high metabolic activity or increased FDG uptake?", "Are there areas where tumor marker expression levels appear elevated, possibly varying by the origin of the primary tumor?", "If bone is present, do you see regions with increased or decreased calcium content, suggesting osteoblastic or osteolytic activity?", "Are there masses with moderate to high water content, possibly due to necrosis or edema?", "Can you identify areas with high cellularity, indicated by densely packed cells?", "Are there cells with an increased nuclear-to-cytoplasmic ratio visible within any of the lesions?", "Is there evidence of moderate or variable fibrosis within any of the masses, depending on tumor type or host response?"], "relational": ["Does the image show abnormal regions within the skeletal, respiratory, nervous, or digestive systems that could indicate secondary involvement?", "Can you identify areas in the bone, liver, lung parenchyma, brain tissue, or lymph nodes that appear distinct from surrounding tissue?", "Is there evidence of lesions in anatomical regions such as the liver, lungs, brain, bones, or lymphatic areas?", "Does the image display any structures adjacent to abnormal masses, such as blood vessels, nerves, or surrounding parenchyma?", "Can you see any regions that might disrupt the skeletal, nervous, respiratory, or hepatic systems?", "Are there signs of abnormal tissue that could be explained by lymphatic spread, lymph node infiltration, or lymphovascular invasion?", "Does the image suggest the presence of masses that may have spread via hematogenous or lymphatic routes, or by direct extension?", "Can you identify areas where malignant tumor cells, stromal cells, inflammatory cells, or endothelial cells might be present within a lesion?", "Is there visual evidence of tissue changes that could be associated with primary tumors such as those originating from the breast, lung, prostate, colon, or skin?", "Are there abnormal findings in organs like the liver, lungs, brain, bones, or lymph nodes that could indicate secondary tumor involvement?"], "contexual_behavior": ["Does the image show any abnormal structures that appear to be invading surrounding tissues, suggesting advanced tumor progression?", "Is there evidence of increased blood vessel formation in areas that might be experiencing low oxygen levels within the tumor microenvironment?", "Can you identify regions that seem less affected by immune cells, indicating possible resistance to immune surveillance?", "Are there abnormal growths that appear larger or more proliferative, potentially in response to hormonal changes?", "Do any of the visible lesions seem less responsive to chemotherapy, as indicated by persistent or growing masses despite signs of treatment?", "Is there an area where normal organ function appears compromised due to the size or invasive nature of a lesion?", "Can you observe signs of increased inflammation or secretion of pro-inflammatory factors in the vicinity of a tumor-host interface?", "Is there evidence that the characteristics of a lesion have changed following surgical intervention, such as altered growth patterns or microenvironment?", "Do any of the abnormal masses appear to have reduced proliferation, possibly due to the effects of targeted molecular therapy?", "Are there features suggesting that certain lesions are evading programmed cell death, such as persistent growth despite cellular stress?", "Can you identify regions with heightened metabolic activity, possibly due to abundant nutrient availability supporting rapid tumor growth?", "Is there a decrease in vascular permeability or stabilization of blood vessels in areas that might have received anti-angiogenic treatment?", "Do you see disruption of normal tissue architecture in regions where tumor mass expansion and invasion are evident?", "Are there signs that abnormal cells have disseminated to distant organs, particularly in the context of weakened immune defenses?", "Can you observe changes in the interaction between tumor cells and the extracellular matrix, especially in areas affected by inflammation?"], "functions": ["Is there evidence of tissue destruction or areas where normal architecture appears to be replaced or disrupted?", "Can you identify regions that might cause functional impairment by altering the structure of the surrounding tissue?", "Does the image show any masses or lesions that appear to invade or compress adjacent tissues?", "Are there signs of local microenvironment alteration, such as abnormal tissue boundaries or irregular growth patterns?", "Can you see features that suggest organ dysfunction or physiological disruption within a specific organ?", "Is there visual evidence of compromised organ function, such as areas where normal tissue is overwhelmed by abnormal growth?", "Are there regions where blood vessels appear compressed, obstructed, or surrounded by abnormal tissue?", "Does the image show signs of abnormal angiogenesis, such as irregular or excessive blood vessel formation near a lesion?", "Can you identify areas that might be experiencing ischemia due to reduced or obstructed blood supply?", "Are there features suggesting an immunosuppressive environment, such as regions with reduced immune cell infiltration around abnormal tissue?", "Does the image show abnormal growth patterns that could indicate immune evasion by a lesion?", "Can you see evidence of disrupted cellular signaling, such as regions with abnormal cell proliferation or irregular tissue organization?", "Are there areas that might be releasing abnormal growth factors, indicated by excessive or uncontrolled tissue expansion?", "Does the image contain features consistent with tumor progression, such as further invasion into surrounding tissues or increased angiogenesis?", "Can you identify regions that might be resistant to therapy, suggested by persistent or expanding abnormal tissue despite surrounding changes?", "Are there signs of increased metabolic demand, such as regions with dense cellularity or altered tissue appearance?", "Does the image show evidence of metabolic reprogramming, such as abnormal tissue patterns or changes in cellular morphology?", "Can you see areas where nerves appear invaded, compressed, or surrounded by abnormal tissue, potentially explaining pain or neurological symptoms?", "Are there features suggesting inflammation or neural compression adjacent to abnormal growths?", "Does the image show secondary tumor sites in distant organs, indicating the spread of cancer?", "Can you identify regions that might contribute to systemic imbalance or homeostatic disruption by affecting multiple organ systems?"]}, "no_questions": {"contexual_properties": ["Can you observe areas where staining intensity is increased, potentially due to higher concentration of the agent or prolonged staining time?", "Is there evidence in the image of a staining agent that has changed color, possibly due to oxidation or exposure to alkaline conditions?", "Does the image show regions with lighter staining that could indicate dilution from the addition of water or alcohol?"], "properties": ["Is there a substance with a refractive index close to 1.650?", "Is there a substance in the image that could have the chemical formula C16H14O6?", "Can you see evidence of a substance with a melting point in the range of 220\u2013223\u00b0C?"], "relational": ["Can you identify structures such as cell nuclei, chromatin, or nucleoli that are distinctly stained?", "Does the image contain epithelial, connective, or muscle tissue with visible nuclear staining?", "Is there evidence of staining that highlights DNA, RNA, or nuclear proteins in the tissue?"], "contexual_behavior": ["Are there regions where nuclear staining is weak, which could be due to prolonged dehydration of the sample?", "Can you identify areas where nuclear material appears unstained or faint, possibly due to necrosis and chromatin loss?", "Does the image display staining variability in areas with high lipid content, such as uneven or patchy nuclear coloration?"], "functions": ["Does the image show cell nuclei that are distinctly visible due to a specific staining procedure?", "Can you observe blue or purple coloration highlighting nuclear material within the tissue?", "Is there a contrast between nuclear features and other cellular or extracellular components, suggesting the use of a counterstain?"]}}, "pancreas": {"yes_questions": {"contexual_properties": ["Does the image show an organ that appears enlarged, which could suggest acute inflammation or the presence of a tumor or cystic lesion?", "Can you identify a structure that appears shrunken or atrophic, as might be seen in long-standing inflammation or advanced metabolic disease?", "Is there evidence of inflammation in a glandular structure, possibly indicating acute or chronic disease processes?", "Does the image reveal a change in color within a gland, which could be associated with hemorrhage, tissue death, or fat accumulation?", "Can you see cystic formations or fluid-filled spaces within a digestive gland, as might occur in pseudocyst or neoplastic conditions?", "Is there visible fat accumulation within a glandular organ, which could be related to obesity or fatty infiltration?", "Does the image show signs of fibrosis or increased tissue density in a digestive gland, suggesting chronic inflammation?", "Can you identify calcifications within a glandular structure, which may result from repeated episodes of inflammation?", "Is there evidence of abnormal hardness or firmness in a gland, potentially due to fibrosis, chronic inflammation, or neoplastic infiltration?", "Does the image show loss of normal tissue architecture in a digestive gland, as might be seen in chronic disease or malignancy?", "Is there visible edema or swelling in a glandular organ, possibly indicating acute injury or trauma?", "Can you detect abnormal masses or nodules within a digestive gland, which could represent neoplasms, cysts, or pseudocysts?", "Does the image reveal changes in duct size within a glandular structure, such as dilation or narrowing, which might be caused by chronic inflammation or obstruction?", "Is there evidence of atrophy in a glandular organ, as might occur after long-term ductal obstruction or chronic disease?", "Can you observe changes in tissue density within a digestive gland, possibly due to fibrosis, fatty infiltration, or necrosis?", "Does the image show areas of tissue necrosis within a gland, which could result from severe acute inflammation or ischemic injury?", "Is there evidence of abnormal cell populations or tumor-like growths within a glandular structure, as seen in cancer or neuroendocrine tumors?", "Can you identify features that might suggest increased hormone content, such as a mass consistent with an insulin-secreting tumor?"], "properties": ["Is there a structure in the image that measures approximately 12 to 15 centimeters in length?", "Can you identify an object with an elongated, tapered, and flattened appearance?", "Does the image show a structure with a pale yellow or pinkish-tan color?", "Is there a soft, lobulated organ visible in the image?", "Can you see a structure whose volume could be around 70 to 100 milliliters?", "Does the image contain tissue that might weigh between 70 and 100 grams in adults?", "Is there an object composed of specialized cells such as acinar, ductal, or islet cells?", "Can you identify a structure that contains hundreds of small lobules?", "Is there a visible organ with moderate connective tissue forming septa and supporting a lobular pattern?", "Does the image show a structure that could be responsible for producing digestive enzymes like amylase or lipase?", "Can you see an object that might secrete hormones such as insulin or glucagon?", "Is there a structure whose fat or lipid content could be estimated at 5 to 15 percent by weight?", "Does the image contain tissue with a water content likely between 70 and 80 percent?", "Can you identify an organ with a protein content of about 10 to 15 percent by weight?", "Is there a structure whose density could be close to 1.05 grams per cubic centimeter?", "Does the image show an object with a carbohydrate content generally less than 1 percent by weight?", "Can you see a structure whose iron concentration might be between 0.5 and 1.5 milligrams per 100 grams of tissue?", "Is there an organ present that would be expected to have a temperature similar to core body temperature, around 37 degrees Celsius?", "Does the image contain a structure with a pH close to neutral, around 7.4?"], "relational": ["Does the image show a structure that is part of both the digestive and endocrine systems?", "Can you identify a region in the image that could correspond to the head, neck, body, tail, or uncinate process of an organ?", "Is there a visible duct that might represent the main pancreatic duct or the accessory pancreatic duct?", "Does the image contain a structure connected to the common bile duct?", "Can you see blood vessels such as the splenic artery or pancreaticoduodenal arteries supplying a particular organ?", "Is there an object located near the duodenum, stomach, spleen, or left kidney?", "Does the image show a structure nestled within the curve of the duodenum?", "Can you identify an area that might contain specialized cells like acinar cells or islet cells?", "Is there evidence of surrounding tissues such as peritoneum, mesentery, or retroperitoneal fat supporting an organ?", "Does the image include a structure situated in the retroperitoneal space of the abdominal cavity?", "Can you see a point where the pancreatic duct and common bile duct converge, possibly forming the ampulla of Vater?"], "contexual_behavior": ["Does the image show a structure that would decrease hormone secretion in response to low blood glucose or sympathetic nervous system activation?", "Can you identify an organ that increases glucagon release during fasting to maintain blood glucose levels?", "Is there a structure whose dysfunction could lead to ineffective blood glucose regulation, as seen in diabetes mellitus?", "Does the image contain an organ that might reduce digestive enzyme production in chronic pancreatitis or cystic fibrosis?", "Can you see a structure that would increase enzyme secretion after a high-fat meal to aid in lipid digestion?", "Is there an object that shows impaired hormone release due to beta-cell dysfunction, as occurs in diabetes?", "Does the image include a structure whose exocrine function could be altered during chronic inflammation, leading to malabsorption?", "Can you identify an organ that decreases bicarbonate secretion in cystic fibrosis due to defective chloride channels?", "Is there a structure that would increase insulin output after carbohydrate intake to facilitate glucose uptake?", "Does the image show an organ that fails to neutralize stomach acid in the duodenum when exocrine insufficiency is present?", "Can you see a structure whose endocrine activity is reduced due to autoimmune attack, as in type 1 diabetes?", "Is there an object that increases enzyme release during acute inflammation, potentially resulting in autodigestion?", "Does the image contain a structure that shows diminished hormone and enzyme secretion with aging?", "Can you identify an organ that alters hormone secretion during stress by increasing glucagon and decreasing insulin output?", "Is there a structure that fails to produce sufficient digestive enzymes in malnutrition due to acinar cell deficiency?", "Does the image show an organ that increases glucagon secretion during hypoglycemia to raise blood glucose?", "Can you see a structure that reduces insulin production in type 1 diabetes due to autoimmune destruction of specific cells?", "Is there an object whose function is altered after partial surgical removal, resulting in decreased hormone and enzyme output?", "Does the image include a structure that increases activity in response to high-protein meals by secreting more digestive enzymes and glucagon?", "Can you identify an organ that fails to regulate metabolism during obesity due to insulin resistance and altered hormone secretion?"], "functions": ["Does the image show a structure that performs both endocrine hormone secretion and exocrine enzyme production?", "Can you identify an organ responsible for regulating blood sugar by releasing hormones that lower or raise glucose levels?", "Is there a structure that aids digestion by secreting enzymes into the small intestine?", "Does the image contain a region where acinar cells might produce digestive enzymes for transport through ducts?", "Can you see an organ involved in hormonal regulation of glucose homeostasis and energy metabolism?", "Is there a structure that contains clusters of cells, such as islets, responsible for secreting insulin and glucagon?", "Does the image show a region where enzymes like lipase, proteases, and amylase could be released into the digestive tract?", "Can you identify a structure that neutralizes stomach acid by secreting bicarbonate-rich fluid into the duodenum?", "Is there an organ that coordinates with the stomach, liver, and small intestine during digestion by releasing enzymes and hormones?", "Does the image include a structure that supports nutrient absorption by providing enzymes for macronutrient breakdown?", "Can you see an organ that detects changes in blood glucose and adjusts hormone secretion to maintain balance?", "Is there a structure involved in regulating metabolism by controlling glucose storage, release, and energy utilization through hormone secretion?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there any abnormality involving the large intestine, particularly the colon?", "Is there evidence of vascular supply from branches of the superior or inferior mesenteric arteries to the affected region?", "Are there signs of secondary involvement in the terminal ileum, perianal region, or skin?"], "contexual_behavior": [], "functions": ["Is there visible mucosal damage or signs of increased epithelial permeability in the colon?", "Is there evidence of delayed mucosal healing or impaired epithelial regeneration in the colon?", "Can you identify areas where immune cells such as macrophages or T cells appear to be persistently activated in colonic tissue?"]}}, "cytomegalovirus": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of infection in organ systems like the respiratory, gastrointestinal, or nervous system?", "Can you identify cells such as epithelial cells or monocytes that may be targeted by a viral pathogen?", "Is there a visible abnormality in tissues like the salivary glands, placenta, lungs, liver, or retina?", "Does the image depict anatomical barriers such as the mucosal epithelium or blood-brain barrier that might be involved in viral entry?", "Can you see any indication of body fluids such as blood or saliva that could harbor a viral agent?", "Is there a structure, such as the salivary glands or kidneys, that could serve as a reservoir for a persistent infection?", "Does the image include blood vessels or lymphatic vessels that could facilitate the spread of an infectious agent?", "Can you identify immune cells or tissues that might be susceptible to viral infection or immune evasion?", "Is there evidence of involvement in anatomical sites commonly affected in congenital infections, such as the brain or spleen?", "Does the image suggest dissemination of infection through pathways like hematogenous or lymphatic spread?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": [], "properties": ["Is there a region that spans approximately 20 to 25 centimeters in diameter, covering the cranial vault?", "Does the image show a region with high opacity or radiopaque appearance?", "Is there evidence of compact bone forming outer and inner layers with a central cancellous region?"], "relational": ["Are there visible lines that could represent the coronal, sagittal, or lambdoid sutures?", "Is there evidence of adjacent structures like the scalp or meninges overlaying the cranial vault?", "Can you identify bones such as the frontal, parietal, or occipital in the image?"], "contexual_behavior": [], "functions": ["Are there radiographic signs suggestive of infection, such as bone erosion or periosteal reaction, in the skull bones?", "Is it possible to assess the continuity, thickness, or density of the cranial bones in this image?", "Does the image provide anatomical details that could assist in planning a neurosurgical procedure by mapping the skull\u2019s structure?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Does the image suggest increased openness of the posterior nasal airway following use of decongestants, anti-inflammatory therapy, or surgical intervention?", "Can you identify signs that suggest improvement in nasal passage openness, such as reduced inflammation or removal of an obstruction?", "Is there a complete obstruction of the posterior nasal airway, as might be seen in cases of bilateral atresia or severe blockage by a foreign object?"], "properties": ["Does the structure in question appear to allow for low resistance airflow, suggesting unobstructed nasal breathing?", "Does the distance between the posterior nasal septum and the edge of the opening measure approximately 2 to 4 millimeters?", "Can you identify an oval or round anatomical opening in the posterior nasal region?"], "relational": ["Can you observe features that would support normal function of the respiratory and olfactory systems in this region?", "Is there evidence of unobstructed airflow from the nasal cavity into the upper respiratory tract?", "Can you identify the region where the nasal cavity connects directly to the nasopharynx?"], "contexual_behavior": ["Is there a mass or abnormal growth in the nasal cavity that could be encroaching on the choanal opening?", "Does the image suggest increased nasal congestion that might be influenced by the individual's body position, such as lying down?", "Are there signs of extensive mucosal inflammation or edema in the nasal or sinus regions, as seen in severe sinusitis?"], "functions": ["Does the image indicate the ability to maintain equalized pressure between the nasal cavity and nasopharynx, supporting normal middle ear and sinus function?", "Does the image show a nasal airway that would support proper growth and development of facial and cranial structures in a pediatric patient?", "Does the image suggest that inhaled air can pass through the nasal mucosa for humidification and filtration before reaching the lower airways?"]}}, "skull cap": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that forms part of the cranium?", "Can you identify bones such as the frontal, parietal, or occipital within the image?", "Is there a region adjacent to the scalp or temporal area visible?", "Does the image display connections between bones that could represent coronal, sagittal, or lambdoid sutures?", "Can you see a surface covered by tissues like periosteum or skin?", "Is there a structure that encloses a cavity for the brain?", "Does the image show a boundary forming the uppermost part of the cranial cavity?", "Are there features suggesting the presence of meninges or blood vessels beneath a bony surface?", "Can you identify membranes such as dura mater, arachnoid mater, or pia mater lining the inner surface of a structure?", "Is there evidence of protection for superior brain structures or the cerebrum in the image?"], "contexual_behavior": ["Is there evidence of a cranial structure with fractures or defects that could reduce brain protection during trauma?", "Does the image show signs of bone density loss or increased brittleness that might indicate decreased impact absorption with age?", "Can you identify areas of bone thinning or reduced mineral content that could suggest osteoporosis affecting cranial protection?", "Are there visible features consistent with congenital defects, such as abnormal bone formation or early suture closure, that might compromise cranial shielding?", "Does the cranial region appear to facilitate increased heat dissipation, possibly in response to fever?", "Is there any indication of disrupted bone integrity due to infection or inflammation, such as changes seen in osteomyelitis?", "Can you observe impaired healing or poor vascular supply in the cranial bones following a fracture?", "Are there structural changes in the cranial region that could be attributed to metabolic bone diseases like rickets or Paget\u2019s disease?", "Does the image reveal localized thinning or remodeling of cranial bones that might result from chronic pressure?", "Are there signs of impaired bone mineralization, such as decreased resistance to penetration, that could be linked to vitamin D deficiency?", "Is there evidence of a depressed fracture or loss of bone continuity that could affect the maintenance of intracranial pressure after injury?", "Can you see alterations in cranial bone structure that might result from surgical removal or repositioning of bone flaps?", "Does the cranial region display features of age-related bone thinning or decreased elasticity, particularly in elderly individuals?", "Are there visual cues of compromised bone matrix or reduced strength in the cranial bones that could be associated with malnutrition?", "Does the image suggest that the cranial structure is serving as a primary barrier against external forces, especially in the context of high-risk activities?"], "functions": ["Does the image show a structure that provides a rigid barrier shielding the brain from external trauma?", "Is there a bony enclosure that helps maintain the shape and stability of the upper portion of the head?", "Can you identify a feature that serves as a protective enclosure for sensory organs such as the eyes and ears?", "Does the image contain a curved bone that could absorb and distribute mechanical forces from impacts?", "Is there a surface present that offers attachment sites for scalp muscles involved in movement and expression?", "Can you see a structure that encloses and safeguards the brain and meninges from external harm?", "Is there evidence of a rigid enclosure that helps maintain intracranial pressure by housing the brain and cerebrospinal fluid?", "Does the image include a bony structure that protects blood vessels within the cranial cavity by encasing them?", "Can you identify a feature that provides structural support to the head and helps prevent brain injury?", "Is there a visible component that contributes to the dissipation of mechanical forces across its curved surface to minimize localized damage?"]}, "no_questions": {"contexual_properties": ["Is there evidence of increased swelling or soft tissue edema on both sides that could indicate an acute inflammatory response?", "Is there increased radiographic visibility of fractures on both sides, possibly due to swelling resolution in early imaging?", "Does the image suggest instability of paired bones, possibly due to lack of fixation in the acute phase?"], "properties": ["Is there a region where the bone appears pale white to yellowish, possibly surrounded by redness?", "Does the affected bone area appear less dense compared to adjacent intact bone, suggesting a density of 0.8 to 1.2 g/cm\u00b3?", "Can you detect swelling at the site of injury measuring between 2 and 5 centimeters in diameter?"], "relational": ["Are ligaments such as collateral or cruciate ligaments near the fracture sites visible or potentially compromised bilaterally?", "Does the image show simultaneous injuries to paired bones on both sides of the body, such as the femur or radius?", "Is there evidence of disruption in cortical or trabecular bone structures on both sides?"], "contexual_behavior": ["Does the image display features that might indicate increased risk of edema due to bilateral injury?", "Does the image suggest greater loss of function in bones that appear osteoporotic or structurally weak?", "Is there evidence of increased inflammation or disrupted bone repair that could be associated with infection at the injury sites?"], "functions": ["Can you observe features that might suggest nerve injury, such as abnormal limb positioning or muscle tone?", "Can you see indications that the individual would have reduced mobility or difficulty performing daily activities independently?", "Is there visual indication of muscle atrophy or weakness in the affected areas?"]}}, "eye": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": [], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for detecting light and forming images?", "Can you identify an area containing photoreceptor cells such as rods and cones?", "Is there evidence of a region where light is focused onto a surface for signal transmission to the brain?", "Does the image include a component that changes shape to adjust image clarity, possibly through the action of ciliary muscles?", "Can you see a part that alters its opening size to adapt to different light intensities, likely involving the iris?", "Is there a structure that contributes to color vision by containing cells sensitive to different wavelengths?", "Does the image suggest the presence of paired structures that could enable depth perception through binocular vision?", "Can you identify muscles around a spherical structure that might coordinate its movement for tracking objects?", "Is there evidence of protective features such as eyelids, eyelashes, or a tear film?", "Does the image show glands or ducts that could be involved in tear production and ocular lubrication?", "Can you see a pathway or connection that might transmit visual signals to the brain, such as an optic nerve?", "Is there a structure that could provide visual input to assist with balance and spatial orientation?", "Does the image suggest a role in regulating circadian rhythms by transmitting light information to the brain?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure located within the male reproductive system that appears abnormal?", "Is there evidence of changes in the area supplied by the inferior vesical artery or drained by the prostatic venous plexus?", "Can you see an abnormality involving the prostatic or ejaculatory ducts?"], "contexual_behavior": [], "functions": ["Can you identify an area that might interfere with local hormone signaling or androgen metabolism?", "Is there evidence of local inflammation, such as immune cell infiltration or regions suggestive of cytokine release?", "Is there an area where the composition or amount of glandular secretions could be decreased or altered?"]}}}
[ { "answer": "several rather large lesions", "extracted_concepts": [ "rather large lesions" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "rather large lesions" ], "question": "does this image show several rather large lesions?" }, { "answer": "no", "extracted_concepts": [ "several rather large lesions", "opened base of skull", "brain" ], "question": "does opened base of skull with brain show several rather large lesions?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "medial aspect" ], "question": "is medial aspect present?" }, { "answer": "exostosis", "extracted_concepts": [ "exostosis" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "exostosis" ], "question": "is exostosis present?" }, { "answer": "no", "extracted_concepts": [ "umbilical cord" ], "question": "is umbilical cord present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "exostosis", "extracted_concepts": [ "exostosis" ], "question": "what is present?" } ]	["opened base of skull", "rather large lesions", "umbilical cord", "bone", "exostosis", "medial aspect", "several rather large lesions", "calvarium", "brain"]	{"opened base of skull": {"yes_questions": {"contexual_properties": ["Is there evidence of increased bleeding that could suggest trauma or a vascular injury?", "Can you observe any abnormal bone erosion that might indicate infection or a neoplastic process?", "Does the image show discoloration that could be due to hemorrhage, bruising, or tissue necrosis?", "Is there visible swelling of tissues that may be associated with infection, inflammation, or edema?", "Can you identify signs of pus accumulation or infection, such as might be seen in osteomyelitis or an abscess?", "Does the image reveal areas of bone thinning that could be related to metabolic bone disease or chronic infection?", "Is there any abnormal tissue growth present that could correspond to a tumor, granuloma, or meningioma?", "Can you see fractures or bone fragments that might result from trauma, surgery, or pathological weakening?", "Does the image display regions of increased vascularity that could be associated with a tumor or arteriovenous malformation?", "Is there evidence of abnormal fluid accumulation, such as might occur with a cerebrospinal fluid leak, edema, or abscess?", "Can you observe changes in bone density that could suggest a metabolic disorder, chronic infection, or neoplastic infiltration?", "Does the image show areas of calcification that might be due to chronic inflammation, a tumor, or a metabolic condition?", "Is there any indication of bone softening that could be consistent with rickets, osteomalacia, or chronic infection?", "Can you detect abnormal color changes in the dura mater that might indicate infection, hemorrhage, or tumor infiltration?", "Does the image demonstrate loss of bone integrity that could result from severe trauma, infection, or advanced neoplastic disease?"], "properties": ["Does the image show a structure with an irregular, concave shape featuring multiple depressions and projections?", "Can you identify a bony area with a typical length of about 13 centimeters from front to back?", "Is there a region present that measures approximately 9 centimeters at its widest point?", "Does the image contain a structure whose overall size could be estimated between 12 to 15 centimeters in length and 8 to 10 centimeters in width?", "Can you see a bony surface that appears off-white to pale yellow in color?", "Is there a structure that seems to weigh between 150 and 250 grams based on its apparent size and density?", "Does the image include bone tissue composed of both compact and cancellous types, with a matrix containing collagen and hydroxyapatite?", "Can you identify a region where the bone thickness varies between 3 and 8 millimeters depending on the area?", "Is there a structure with a bone density estimated between 1.5 and 2.0 grams per cubic centimeter?", "Does the image show a hard, slightly porous bone with a rough internal surface?", "Can you see a bony structure with a surface area likely between 100 and 150 square centimeters?", "Is there evidence of mineral content, such as calcium and phosphate in the form of hydroxyapatite, making up about 65% of the bone mass?", "Can you identify a region where the water content of the bone might be around 20% by weight?", "Does the image display anatomical landmarks such as the foramen magnum, sella turcica, clivus, or the petrous part of the temporal bone?", "Are there visible foramina, including the foramen magnum, jugular foramen, carotid canal, foramen ovale, or foramen spinosum?"], "relational": ["Does the image show a region formed by bones such as the occipital, sphenoid, temporal, ethmoid, or frontal bones?", "Can you identify areas corresponding to the anterior, middle, or posterior cranial fossae?", "Is there evidence of large openings such as the foramen magnum or jugular foramen?", "Does the image display multiple foramina, including the foramen ovale, foramen spinosum, foramen rotundum, carotid canal, hypoglossal canal, or cribriform plate foramina?", "Can you see passageways that would allow cranial nerves, such as the olfactory or optic nerves, to traverse the structure?", "Is there a visible pathway for major blood vessels like the internal carotid artery or vertebral artery?", "Does the structure provide support for regions of the brain, such as the frontal lobes, temporal lobes, brainstem, or cerebellum?", "Are there attachment points for membranes like the dura mater, arachnoid mater, or pia mater?", "Can you identify features that form the inferior boundary of the cranial cavity and provide passageways for neurovascular structures?", "Is there a connection to the vertebral column through structures such as the foramen magnum or occipital condyles?", "Does the image show distinguishing features such as exposed fossae, visible foramina, or the absence of the calvaria and overlying soft tissues?", "Is the cranial floor directly visible, indicating an opened rather than intact skull base?"], "contexual_behavior": ["Does the image show a disruption of the bony floor that could expose neural structures to external injury?", "Is there evidence of a breach that might allow cerebrospinal fluid to escape from the cranial cavity?", "Can you identify a loss of anatomical continuity that would increase the risk of infection entering the intracranial space?", "Does the image reveal compromised bony margins around foramina, potentially making cranial nerves more vulnerable?", "Is there visible exposure or injury to blood vessels traversing the cranial cavity, suggesting a risk of hemorrhage?", "Can you see an opening that would prevent the cranial vault from maintaining normal intracranial pressure?", "Does the image show disruption of venous sinuses or emissary veins that could impair drainage of blood from the brain?", "Is there a loss of structural support that might increase the risk of abnormal brain displacement or herniation?", "Can you identify a breach in anatomical barriers such as the tentorium or falx, altering communication between cranial compartments?", "Does the image reveal abnormal connections between the cranial cavity and adjacent spaces, such as sinuses or nasal cavities, that could allow air or fluid to pass through?", "Is there evidence of reduced mechanical stability of the head, making it more susceptible to further trauma?", "Can you see a defect that would allow blood to escape from the cranial vault, reducing the containment of hemorrhage?", "Does the absence of a rigid cranial base suggest altered movement or deformation of brain tissue during head injury?", "Is there a disruption of the sella turcica that could affect the function or environment of the pituitary gland?", "Can you identify a pathway that would allow pathogens from the nasal or oral cavities to ascend into the cranial cavity due to loss of anatomical barriers?"], "functions": ["Does the image show a surgical approach that provides access to the cranial base for treating underlying pathologies?", "Can you identify a procedure that allows direct visualization of intracranial structures such as the brainstem or cranial nerves?", "Is there evidence of an intervention designed to expose deep-seated anatomical regions for tumor or lesion removal?", "Does the image depict a method that enables decompression of neural tissues by relieving pressure from swelling or masses?", "Can you see a surgical field that offers access to major blood vessels for vascular repair or hemostasis?", "Is there an indication of controlled cerebrospinal fluid drainage to manage intracranial pressure during surgery?", "Does the image include features consistent with trauma management, such as evacuation of hematomas or repair of cranial fractures?", "Can you identify an exposure that facilitates microsurgical repair of cranial nerve injuries?", "Is there visual evidence of a surgical approach aimed at improving lesion access, relieving symptoms, or restoring neurological function?", "Does the image show a procedure that enables drainage or debridement of infected tissue within the cranial cavity for infection or abscess management?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure with features such as slow growth, lack of invasion, and absence of metastasis?", "Does the image contain a lesion adjacent to blood vessels, nerves, or surrounding parenchyma?", "Does the image show a lesion that is encapsulated or surrounded by a fibrous capsule?"], "contexual_behavior": [], "functions": ["Does the image show a localized area of tissue enlargement with well-defined and possibly encapsulated borders?", "Can you identify a mass that induces symptoms related to pressure on adjacent anatomical structures?", "Is there evidence of a mass effect causing pressure or obstruction that could impair the function of a nearby organ?"]}}, "rather large lesions": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to have increased in size, possibly due to cellular proliferation, inflammation, or tumor growth?", "Can you identify an area that seems to have decreased in size, suggesting a response to treatment, immune clearance, or tissue resolution?", "Does the image show a region with color changes that might be explained by vascular changes, hemorrhage, or pigment deposition?", "Is there a raised area that could be the result of edema, cellular infiltration, or extracellular matrix accumulation?", "Can you see a region where the surface appears ulcerated, potentially due to ischemia, infection, or malignancy?", "Is there a firm-appearing area that might indicate fibrosis, calcification, or dense cellular infiltration?", "Does the image contain a softened region that could be due to necrosis, liquefaction, or cystic degeneration?", "Can you identify a structure with a noticeably altered texture, possibly from changes in cellular composition, extracellular matrix, or fluid content?", "Is there an area with an irregular shape that could result from invasive growth, uneven cell proliferation, or tissue destruction?", "Does the image show a region with necrotic tissue, suggesting compromised blood supply or rapid cell death?", "Is there evidence of fluid accumulation in a structure, which might be due to increased vascular permeability or impaired lymphatic drainage?", "Can you see a region that appears more vascularized, possibly as a result of angiogenesis in response to hypoxia or tumor growth?", "Is there an area with increased cellularity, indicating active proliferation of neoplastic or inflammatory cells?", "Does the image show a region with calcification, which could be due to dystrophic or metastatic mineral deposition?", "Can you identify a structure with poorly defined borders, possibly resulting from infiltrative growth or inflammation?", "Is there evidence of hemorrhage within a region, which might be due to vessel rupture, trauma, or vascular invasion?", "Does the image show an area with signs of inflammation, such as redness or swelling, that could be due to immune activation or infection?", "Is there a region that appears metabolically active, possibly reflecting rapid cell division or heightened inflammatory processes?", "Can you see a structure with altered composition, such as changes in cellular, stromal, or fluid components?", "Is there evidence of fibrosis in a region, suggesting chronic inflammation, tissue repair, or collagen deposition?"], "properties": ["Does the image show a structure measuring between 5 and 10 or more centimeters in its greatest dimension?", "Can you identify an area with an average diameter of approximately 7 to 10 centimeters?", "Is there a region that appears round, oval, or irregular in shape?", "Do you see a structure that is pale, red, or otherwise discolored compared to surrounding tissue?", "Is there an area with a surface texture that looks smooth, nodular, or rough?", "Can you find a region with an estimated volume between 65 and 500 cubic centimeters?", "Does the image contain a surface that appears raised, ulcerated, or remains intact?", "Is there a structure with borders that are either sharply defined or poorly demarcated?", "Can you identify an area that appears soft, firm, or hard in consistency?", "Is there a region that seems to extend several millimeters to multiple centimeters in depth, possibly involving deeper tissues?", "Do you observe a structure that may have grown at a moderate or rapid rate?", "Is there an area composed of abnormal tissue, such as neoplastic, inflammatory, or necrotic material?", "Can you see a structure that might weigh between 50 and several hundred grams based on its size and appearance?", "Does the image show a region with increased vascularity or visible new blood vessels?", "Is there an area that appears densely cellular, suggesting high cellular proliferation?", "Can you identify a region that may have elevated water content, possibly due to edema or necrosis?", "Is there a structure that appears either less dense, more dense, or similar in density compared to surrounding tissue?", "Do you see a region that might have an elevated temperature, possibly due to inflammation or infection?", "Is there an area that could be slightly acidic, especially if necrosis or inflammation is suspected?", "Can you identify a structure that shows evidence of calcification, or is it absent?"], "relational": ["Is there an abnormal area present within epithelial, connective, or muscle tissue?", "Can you identify a region in the image affecting organs such as the liver, lungs, kidneys, brain, or skin?", "Does the image show a prominent structure located in the abdominal cavity, thoracic cavity, cranial region, or subcutaneous tissue?", "Is there an area adjacent to blood vessels, nerves, lymph nodes, or surrounding parenchyma that appears abnormal?", "Can you see a region that might contain inflammatory cells, neoplastic cells, fibroblasts, or endothelial cells?", "Does the image reveal a structure that could impact the nervous, respiratory, digestive, or musculoskeletal systems?", "Is there evidence of a mass compressing, infiltrating, or displacing nearby tissues?", "Can you observe a structure with defined margins, capsule formation, or a distinct interface with normal tissue?", "Does the image show involvement of arteries, veins, lymphatic vessels, or bile ducts by an abnormal region?", "Is there a large abnormality located within the intracranial, intrathoracic, abdominal, or subcutaneous compartments?"], "contexual_behavior": ["Is there an area of tissue damage that appears extensive enough to limit the regenerative capacity of resident cells?", "Can you identify a region where local blood flow might be disrupted due to extensive vascular damage or compression, especially under hypoxic conditions?", "Does the image show a site where immune cell recruitment and cytokine release could be amplified, suggesting an enhanced inflammatory response during infection?", "Is there evidence of delayed wound healing in a patient with diabetes, possibly due to impaired angiogenesis and chronic inflammation in a large area of tissue damage?", "Can you see a region where significant tissue loss or replacement by non-functional scar might reduce organ function after trauma?", "Is there a visible area where excessive fibroblast activity and collagen deposition could be promoting abnormal scar formation during healing?", "Does the image suggest compromised barrier function and increased susceptibility to secondary infections, possibly due to loss of tissue integrity and reduced immune surveillance?", "Can you identify a region where persistent tissue damage might be altering immune cell infiltration, as seen in chronic disease?", "Is there an area where disrupted or occluded vascular supply could be decreasing nutrient delivery to surrounding tissues?", "Does the image show a region where exposed or sensitized nerve endings might be exacerbating pain signaling during inflammation?", "Is there evidence of impaired barrier function in epithelial tissue, where continuity is lost over a broad area?", "Can you see a wound area that appears too large for effective re-epithelialization by migrating epithelial cells?", "Is there a region where chronic inflammation and prolonged cellular turnover might increase the risk of malignant transformation?", "Does the image show widespread immune-mediated destruction that disrupts normal tissue architecture, as might occur in autoimmune conditions?", "Is there a region where impaired perfusion and increased interstitial pressure could hinder effective drug delivery to affected tissue?", "Can you identify an area where oxygen and nutrient deprivation might be altering local metabolic activity in an ischemic environment?", "Does the image suggest impaired functional recovery after surgical intervention, possibly due to insufficient regenerative processes in a large area of tissue loss?", "Is there evidence of increased edema formation during acute injury, potentially due to amplified vascular permeability and fluid leakage in a large region?", "Can you see a region in cardiac tissue where scar tissue might be interrupting normal electrical conduction pathways?", "Does the image show a burden of tissue damage that could worsen organ dysfunction in the presence of systemic inflammation?"], "functions": ["Does the image show an area where tissue structure appears extensively disrupted, potentially leading to loss of normal cellular activity?", "Is there a region that could be interrupting normal physiological processes, such as signaling pathways or metabolic activity?", "Can you identify a part of the image where organ function might be compromised due to a reduction in effective working area?", "Is there evidence of a structure that could be compressing or obstructing blood vessels, possibly resulting in abnormal local blood flow?", "Does the image contain an area where tissue regeneration or repair might be hindered, such as by destruction of progenitor cells?", "Can you see a region that appears to be attracting inflammatory cells or showing signs of chronic inflammation?", "Is there a visible area that could be facilitating further tissue damage or promoting chronic pathological changes?", "Does the image show a region where cell-to-cell communication or molecular transport might be disrupted?", "Can you identify an area where nutrient or oxygen delivery could be compromised due to increased diffusion distances or damaged blood vessels?", "Is there evidence of a region that might be promoting or inhibiting inflammation, such as by releasing damage-associated molecular patterns or showing signs of tissue necrosis?"]}, "no_questions": {"contexual_properties": [], "properties": ["Are there indications of elevated synovial fluid white blood cell counts, possibly ranging from 5,000 to 50,000 cells/\u03bcL?", "Does the image display subcutaneous nodules in approximately 20 to 30% of the individuals shown?", "Does the image suggest the presence of anemia, with hemoglobin levels likely between 10 and 12 g/dL?"], "relational": ["Can you identify abnormalities in joints such as those of the hands, wrists, feet, or knees?", "Is there evidence of joint deformity or bone erosions in the regions commonly affected by autoimmune processes?", "Are there signs of connective tissue involvement, such as changes in the synovium, tendons, or ligaments?"], "contexual_behavior": [], "functions": []}}, "umbilical cord": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the fetal circulatory or placental system?", "Can you identify a conduit connecting the placenta to the developing individual?", "Is there a visible structure containing two arteries and one vein?", "Does the image include tissue resembling Wharton's jelly or amniotic epithelium?", "Can you see a structure that facilitates nutrient and gas exchange between the placenta and the fetus?", "Is there an object physically attached to the developing individual's abdominal wall at the site of the future umbilicus?", "Does the image show a structure surrounded by the amniotic membrane?", "Is there a feature traversing the amniotic cavity between the placenta and the fetal abdomen?", "Can you identify something adjacent to amniotic fluid, the chorionic plate, or the yolk sac?", "Does the image include a structure that serves as a lifeline during fetal development?"], "contexual_behavior": [], "functions": ["Does the image show a structure that physically connects the developing fetus to the placenta?", "Can you identify an object that serves as a conduit for nutrient and gas exchange between the fetus and the placenta?", "Is there a feature present that enables the removal of waste products from the fetus to the placenta?", "Does the image contain a vessel that could transport oxygenated blood from the placenta to the fetus?", "Can you see a structure that contains both arteries and a vein to regulate blood flow between the fetus and placenta?", "Is there evidence of a pathway that allows hormone transfer between the mother and fetus?", "Does the image include a structure that supports fetal growth by supplying essential nutrients and oxygen?", "Can you identify a feature that might facilitate the passage of maternal antibodies, such as immunoglobulin G, to the fetus?", "Is there a visible object that plays a role in maintaining proper circulatory support between the fetus and placenta?"]}, "no_questions": {"contexual_properties": ["Is there a lung lesion with central cavitation, indicating the presence of air-filled spaces from necrosis?", "Is there evidence of calcification within a lung lesion, possibly due to dystrophic calcification in necrotic tumor areas?", "Is there evidence of increased tissue density in a lung region, possibly due to cell proliferation or fibrosis?"], "properties": ["Does the image show any round or ovoid structures measuring between 1 mm and 5 cm in diameter?", "Can you identify nodules with variable lipid content or occasional calcification?", "Are there features suggestive of elevated enzyme activity, such as tissue breakdown or invasion into surrounding structures?"], "relational": ["Is there tissue present that resembles alveolar or bronchial epithelium along with abnormal masses?", "Does the image show a region near the heart or ribs?", "Can you see connective tissue or tumor tissue within a respiratory structure?"], "contexual_behavior": ["Do you observe regions with abnormal vasculature or reduced alveolar surface area that could contribute to hypoxia and impaired gas exchange?", "Does the image reveal areas with suppressed local immune surveillance, such as accumulation of regulatory immune cells?", "Does the image show evidence of tissue that might exhibit increased resistance to chemotherapy, such as features associated with drug efflux or survival signaling?"], "functions": ["Does the image show evidence of tissue that could serve as a site for secondary tumor growth?", "Is there any indication of airway obstruction or reduced airway patency in the image?", "Can you see any structures that might facilitate further dissemination of cancer cells to other organs?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see any involvement of anatomical landmarks such as the epiphysis, diaphysis, metaphysis, or articular surface?", "Can you detect abnormalities in bones that are weight-bearing or appear osteoporotic?", "Does the image suggest an impact on organ systems like the circulatory or nervous system adjacent to a skeletal abnormality?"], "contexual_behavior": [], "functions": ["Can you see features suggesting debris clearance or recruitment of repair cells at a site of tissue regeneration?", "Can you identify features consistent with immobilization, such as maintained bone alignment or restricted movement at the injury site?", "Does the image suggest the influence of regulatory mechanisms, such as growth factors or cytokines, in the healing process?"]}}, "exostosis": {"yes_questions": {"contexual_properties": ["Is there a bony projection that appears larger in areas of active bone growth or where mechanical stress is evident?", "Can you identify multiple outgrowths that might suggest a hereditary condition or repeated trauma?", "Do any of the bony protrusions show changes in shape or orientation that could be due to maturation or biomechanical remodeling?", "Is there a visible area of increased bone density or mineralization that could indicate progressive ossification?", "Does the image show a structure that becomes more prominent as it enlarges, calcifies, or as surrounding soft tissue recedes?", "Can you see an outgrowth with an irregular or uneven surface, possibly due to degenerative changes or uneven bone deposition?", "Is there evidence of altered mineral composition in a bone outgrowth, which might be linked to active bone turnover or metabolic bone disease?", "Does the image suggest compression of nearby nerves or tissues, or signs of inflammation adjacent to a bony projection?", "Is there a reduction in the size of a bony outgrowth that could indicate surgical removal or spontaneous regression?", "Do you observe a shift in the location of a bone projection that might be associated with bone growth, displacement, or trauma?", "Is there a bony structure that appears more calcified or mineralized as it matures?", "Can you identify increased vascularity around a bone outgrowth, possibly indicating early growth or inflammation?", "Does any bony projection appear less defined, perhaps due to surrounding edema, soft tissue reaction, or being in an early developmental stage?", "Is there a visible alteration in the contour of a bone due to an enlarging projection from its surface?", "Can you see a cartilage cap of varying thickness on a bone outgrowth, especially one resembling an osteochondroma?"], "properties": ["Does the image show an irregular or nodular outgrowth projecting from the surface of a bone?", "Can you identify a radiodense structure with density similar to cortical bone?", "Is there a well-defined bony projection located near a joint or at a tendon attachment site?", "Does the image contain a structure that appears hard and rough, with a texture matching that of normal bone?", "Can you see an outgrowth whose size ranges from a few millimeters to several centimeters in diameter?", "Is there a visible lesion that appears white to pale yellow, consistent with bone tissue coloration?", "Does the image show a structure with a surface contour that is irregular or lobulated, possibly with a smooth cap?", "Is there evidence of a slow-growing, gradually developing bony projection?", "Can you identify a structure composed primarily of mature bone tissue, possibly with a cartilage cap?", "Does the image include a dense outgrowth whose mineral content would likely consist of hydroxyapatite and calcium phosphate?", "Is there a firm, pressure-resistant projection with hardness similar to cortical bone?", "Can you see a bony lesion whose thickness appears to be in the range of millimeters to over a centimeter?"], "relational": ["Does the image show an abnormal growth involving bone or cartilage tissue?", "Can you identify a structure that appears to originate from the periosteum?", "Is there a bony outgrowth visible on a long bone such as the femur, tibia, or humerus?", "Does the image contain an irregular surface or a cartilage-capped projection on a bone?", "Can you see a structure that could impact the skeletal or musculoskeletal system?", "Is there an abnormal bone formation near a joint such as the knee, elbow, shoulder, or ankle?", "Does the image show a growth adjacent to muscles, tendons, nerves, or blood vessels?", "Can you identify a feature that might result from endochondral ossification or appositional growth?", "Is there a visible outgrowth on the jaw, skull, or ribs?", "Does the image show a bone structure interacting with ligaments, tendons, or joint capsules?"], "contexual_behavior": ["Is there evidence of a bony projection that could limit joint movement or cause impingement during physical activity?", "Can you identify a structure that might cause increased pain or sensitivity when subjected to mechanical stress or repetitive pressure?", "Does the image show a growth near neural structures that could result in nerve compression or neuropathy?", "Is there a sign of abnormal bone formation that may indicate disrupted bone remodeling due to repetitive trauma?", "Can you see a bony prominence that could restrict range of motion, especially during periods of rapid skeletal growth?", "Is there a feature that might increase susceptibility to local inflammation or irritation following injury?", "Does the image show abnormal bone growth that could disrupt normal bone function in the context of metabolic bone disease?", "Can you identify a bony outgrowth that interferes with the normal attachment sites of tendons or ligaments, potentially limiting movement?", "Is there a structure that could cause functional limitations or increased discomfort in cold environments due to reduced tissue flexibility?", "Does the image reveal a lesion that might impair weight-bearing or alter gait during walking or running?", "Can you see evidence of a bony mass that could compress nearby blood vessels and alter local perfusion, especially during periods of rapid bone growth?", "Is there a feature that could exacerbate discomfort or swelling during pregnancy due to hormonal or biomechanical changes?", "Does the image show a bony prominence that reduces the protective function of surrounding soft tissues, increasing vulnerability to abrasion?", "Can you identify a pre-existing outgrowth that might worsen functional impairment or delay recovery after acute trauma?", "Is there evidence of abnormal bone formation that could interfere with normal bone healing or increase the risk of malunion after a fracture?"], "functions": ["Is there evidence of an abnormal bone projection that could interfere with normal anatomical function?", "Does the image show a bony outgrowth that might restrict joint movement or reduce mobility?", "Can you identify a structure that appears to alter bone mechanics by changing load distribution or increasing local stress on adjacent tissues?", "Is there a visible feature that could be compressing or irritating surrounding soft tissues, potentially leading to inflammation or tissue damage?", "Does the image suggest the presence of a slowly enlarging, benign bone growth?", "Is there a structure that might be impinging on nearby nerves, possibly causing numbness, tingling, or neuropathic pain?", "Can you see any indication of local blood vessel compression that could reduce perfusion near a bony outgrowth?", "Does the image contain a feature that could be responsible for pain or discomfort due to mechanical irritation, inflammation, or nerve involvement?", "Is there a bony projection that appears to provide localized reinforcement but could also destabilize the bone if excessive?", "Can you identify a structure that might interfere with the normal gliding of tendons or ligaments, leading to restricted movement or inflammation?"]}, "no_questions": {"contexual_properties": ["Does the image show signs of wear or damage, possibly from harsh weather, repeated use, or predator attacks?", "Does the image show a structure that looks fragile, potentially from moisture damage, aging, or pest activity?", "Does the image show a change in texture that could result from material changes, weathering, or occupant modifications?"], "properties": ["Can you identify an object with an outer framework of coarse materials and an inner lining of softer substances?", "Is there a structure whose diameter seems to fall between 10 and 30 centimeters?", "Does the image show a structure with a depth that could be between 3 and 10 centimeters, as seen in cup-shaped forms?"], "relational": ["Do you see cell groups interacting with basement membrane, capillaries, or immune cells at the microscopic level?", "Can you observe compact groups of cells with clear boundaries and high cellular density?", "Does the image contain structures that are components of glands, tumors, or epithelia?"], "contexual_behavior": ["Does the image show a structure that could be compromised by environmental contaminants, possibly affecting the development of young animals?", "Is there a structure that could enhance the survival of young animals when food resources are abundant and parental care is evident?", "Can you see an object that appears less functional due to visible signs of disease or infestation?"], "functions": ["Is there a centralized location visible that would facilitate parental care behaviors such as feeding, brooding, or guarding offspring?", "Is there a structure present that would support incubation by enabling consistent warmth and controlled environmental conditions for eggs?", "Does the image suggest the presence of a shared space that could be important for group breeding, cooperation, or communal living among organisms?"]}}, "medial aspect": {"yes_questions": {"contexual_properties": ["Does the image show an area that appears swollen, possibly due to trauma or infection?", "Can you identify a region with discoloration that might suggest bruising or vascular compromise?", "Is there a visible area that could be tender to touch because of inflammation or injury?", "Do you see any evidence of fluid accumulation, such as edema, possibly from venous stasis or lymphatic obstruction?", "Is there a region that appears warmer than surrounding areas, which could indicate infection or cellulitis?", "Can you spot an area that looks bruised, suggesting recent blunt trauma or vascular injury?", "Is there a part with abnormal texture, such as thickening or scarring, that could result from chronic inflammation or dermatological disease?", "Do you observe any redness that might be caused by increased blood flow from inflammation or allergic reactions?", "Is there a region where the normal contour is lost, possibly due to swelling, mass formation, or deformity?", "Can you see any thickened skin that could be due to chronic dermatitis or repeated trauma?", "Is there an area that appears unusually pale, suggesting poor perfusion or anemia?", "Do you notice any lesions, such as ulcers or rashes, that could indicate infection or autoimmune disease?", "Is there a region that might be more sensitive to touch, possibly due to neuropathy or inflammation?", "Can you identify an area that looks indurated, which could be a sign of chronic inflammation or neoplastic infiltration?", "Is there evidence of abnormal pigmentation, such as hyperpigmentation or melanosis, possibly from chronic venous insufficiency or post-inflammatory changes?"], "properties": ["Is there a region in the image whose shape appears to vary depending on the surrounding anatomical context?", "Can you identify an area that generally has a smooth surface, though its texture might differ based on its location?", "Does the image show a region with a color similar to adjacent tissue, possibly pale pink or light red?", "Is there a structure whose width and length seem to depend on the specific organ or region depicted?", "Can you see an area where the thickness is not uniform and appears to be determined by the underlying anatomical structure?", "Does the image contain a region composed of tissues such as epithelial, connective, muscle, or nervous tissue, depending on its location?", "Is there a part of the image that likely contains both cells and extracellular matrix, reflecting the composition of the underlying tissue?", "Can you identify an area that would be expected to have a temperature close to core body temperature, around 36.5\u201337.5\u00b0C?", "Is there a region that might have a water content similar to the surrounding tissue, typically between 60% and 80%?", "Does the image show an area whose density would be expected to match that of soft tissues, approximately 1.01\u20131.06 g/cm\u00b3?", "Can you identify a region that, if measured, would likely have a physiological pH between 7.35 and 7.45?"], "relational": ["Does the image show a structure that is closer to the body's midline compared to others?", "Can you identify any features such as the nasal septum, medial malleolus, or the medial condyle of the femur?", "Is there a region visible that corresponds to the inner thigh, the medial side of the arm, or the medial side of the foot?", "Can you see any bones like the tibia, humerus, femur, or scapula with a surface oriented toward the midline?", "Does the image include muscles such as the gracilis, adductor longus, adductor brevis, or adductor magnus located on the inner thigh?", "Are there nerves present that run along the inner side of the arm, such as the ulnar nerve or the medial cutaneous nerve of the forearm?", "Can you identify blood vessels like the great saphenous vein or femoral artery that are associated with the inner side of the leg?", "Is there a joint visible, such as the knee, elbow, or ankle, where you can distinguish the side nearest to the midline?", "Do you see organs such as the lungs, kidneys, or testes with a surface oriented toward the body's midline?", "Can you determine which side of a structure is nearest to the anatomical midline based on its orientation in the image?"], "contexual_behavior": ["Is there evidence of reduced sensation on the inner side of a limb, possibly due to injury of nerves responsible for cutaneous sensation?", "Does the image show altered movement or swelling on the inner side of a joint that could indicate inflammation or synovitis?", "Can you observe increased mechanical stress or load on the inner side of a limb or joint, as might occur with abnormal gait patterns such as overpronation or knock-knee alignment?", "Is there a sign of instability on the inner side of the knee that could suggest damage to a ligament responsible for resisting valgus forces?", "Does the image suggest that the inner portion of an organ is compensating for damage to its outer portion, as might occur after unilateral injury?", "Can you see overactivity or hypertrophy of muscles on the inner side of a limb, possibly as a compensatory response to weakness on the outer side?", "Is there evidence of impaired growth or deformity on the inner side of a bone, which could be consistent with developmental disorders such as Blount disease or rickets?", "Does the inner wall of a blood vessel appear altered, possibly indicating changes in blood flow due to vascular disease like stenosis or thrombosis?", "Can you identify areas on the inner side of a limb or body part that are more susceptible to pressure-related injury, such as pressure ulcers in immobile patients?", "Is there a reduction in balance contribution from the inner side of the foot, which might be associated with sensory loss or neuropathy?"], "functions": ["Does the image show a region that facilitates movement toward the body's midline, such as adduction or internal rotation?", "Is there an area visible that provides attachment sites for ligaments or muscles resisting lateral forces to enhance joint stability?", "Can you identify a structure that aligns with the midline axis and appears to transmit weight-bearing forces efficiently across the body?", "Does the image contain a reference point or region that could help coordinate symmetrical movement or alignment between the left and right sides?", "Is there a part of the image that might house sensory receptors important for detecting joint position and contributing to balance?", "Can you see a region that acts as a barrier or support for soft tissues adjacent to the body's midline, potentially protecting internal structures?", "Does the image display anatomical landmarks that could guide muscle attachment and influence muscle function?", "Is there an area that appears to serve as a pathway for blood vessels or nerves traveling along the body's midline?"]}, "no_questions": {"contexual_properties": ["Is there visible volume loss or wasting on one side that could be caused by muscle atrophy, tissue wasting, or nerve injury?", "Is there an abnormal growth, such as a tumor, cyst, or nodule, present on one side?", "Does one side appear larger than the other, possibly due to edema, tumor growth, or unilateral hypertrophy?"], "properties": ["Does the depicted region show a fat distribution pattern that mirrors the opposite side, with subcutaneous and visceral fat varying by sex, age, and genetics?", "Can you observe a region on the scalp with a hair density of about 60 to 100 follicles per square centimeter, with possible regional variation?", "Can you identify an area that represents approximately half of the total body surface area?"], "relational": ["Can you identify the left gastric artery or left renal vein in the image?", "Can you see lymphatic structures like the thoracic duct or left axillary lymph nodes?", "Does the image include structures unique to one side, such as the aortic arch or spleen?"], "contexual_behavior": ["Can you observe increased muscle tone or spasticity on one side, which could be characteristic of a motor disorder like cerebral palsy?", "Is there a visible indication of reduced sensation, such as numbness or altered touch response, on one side that might be due to nerve injury?", "Does the image show swelling or fluid accumulation on one side that could be consistent with lymphedema or lymphatic obstruction?"], "functions": ["Can you identify thoracic structures that contribute to pulmonary ventilation or respiratory mechanics on one side?", "Does the image display any structures involved in motor coordination or neuromuscular control specific to one half?", "Can you see anatomical features that would be responsible for proprioception or postural control on a particular side?"]}}, "several rather large lesions": {"yes_questions": {"contexual_properties": ["Does the image show multiple abnormal areas that are noticeably larger than surrounding structures?", "Can you identify more than one region with irregular size or appearance compared to the rest of the tissue?", "Are there several distinct areas that appear larger than typical anatomical features in the image?", "Does the image contain multiple regions that differ in size or shape from the surrounding tissue?"], "properties": ["Does the image show multiple abnormal areas that appear larger than typical surrounding structures?", "Can you identify more than one region that differs in size and appearance from the rest of the tissue?", "Are there several distinct areas that are noticeably larger than other features in the image?", "Does the image contain multiple sizable regions that might indicate pathological changes?"], "relational": ["Does the image show abnormal areas affecting epithelial, connective, or muscle tissue?", "Can you identify any regions within organs such as the liver, lung, kidney, or brain that appear disrupted?", "Is there evidence of large abnormal structures located in the abdominal, thoracic, or cerebral regions?", "Do you see any masses adjacent to blood vessels, nerves, or surrounding parenchyma?", "Are there visible changes that could impact the nervous, digestive, or respiratory systems?", "Can you detect areas that might contain inflammatory, necrotic, or tumor cells?", "Is there visual evidence of tissue compression, invasion, or local inflammation near abnormal regions?", "Do any large abnormal structures appear within the intracranial, abdominal, or thoracic cavities?", "Are the boundaries of any abnormal areas defined by distinct margins, a capsule, or adjacent tissue planes?", "Can you see any association between abnormal regions and arteries, veins, bile ducts, or lymphatic vessels?"], "contexual_behavior": ["Does the image show multiple areas where extensive tissue damage and disruption of the extracellular matrix might impair healing?", "Can you identify regions where a significant portion of an organ's structure appears compromised, potentially affecting its function under stress?", "Are there visible sites where underlying tissues are exposed, possibly increasing the risk of secondary infection?", "Does the image reveal areas where the extent of damage could overwhelm local regenerative capacity or deplete progenitor cells, slowing tissue regeneration?", "Can you see evidence of excessive or prolonged immune cell recruitment, suggesting altered local immune responses during inflammation?", "Are there regions where local blood vessels appear compressed or damaged, potentially reducing blood supply to surrounding tissues?", "Does the image display disruption of cellular architecture that might interfere with metabolic processes or impair nutrient exchange?", "Can you identify large contiguous areas of destroyed protective tissue, indicating a loss of barrier function in the skin or mucosa?", "Are there wounds of increased size or complexity that could complicate closure and delay recovery after surgical intervention?", "Does the image show involvement of richly innervated tissues or stretched nerve endings, which might exacerbate pain signaling during movement?", "Are there signs of disrupted microcirculation or increased tissue edema that could impair nutrient delivery to adjacent cells?", "Can you observe features that might facilitate pathogen dissemination or trigger widespread inflammation, increasing susceptibility to systemic complications?", "Does the image suggest accumulation of cellular debris, possibly due to overwhelmed local phagocytic capacity?", "Are there indications of persistent tissue injury or dysregulated cytokine production, reflecting an altered inflammatory response during healing?", "Can you see areas where increased diffusion distances or necrotic zones with poor perfusion might reduce the effectiveness of local drug delivery?"], "functions": ["Does the image show areas where tissue or organ function appears compromised due to structural disruption?", "Can you identify regions that might interfere with normal physiological processes such as cellular signaling or nutrient exchange?", "Is there evidence of reduced blood flow or vascular damage in any part of the tissue?", "Does the image display features suggesting delayed healing or signs of chronic inflammation?", "Are there regions that could be triggering an inflammatory response, possibly through the release of damage-associated molecular patterns?", "Can you see areas that might be attracting immune cells or promoting cytokine release?", "Is there visual indication of nerve damage or altered sensation, such as swelling or changes in tissue appearance?", "Do any regions appear to induce hypoxia, edema, or mechanical stress on surrounding healthy tissue?", "Is there evidence of reduced organ efficiency or signs that could suggest systemic complications like infection or organ failure?", "Can you identify features that might indicate persistent tissue injury, fibrosis, or an increased risk of malignant transformation?"]}, "no_questions": {"contexual_properties": ["Is there a structure that seems to have lost its capsule and is infiltrating adjacent tissues, indicating invasive behavior?", "Is there a structure in the image that appears to be increasing in size, suggesting active cell division or growth?", "Do you see a region that looks softened, perhaps as a result of necrosis, liquefaction, or cyst formation?"], "properties": ["Does the image suggest the presence of cells with abnormal DNA content, such as aneuploidy or increased DNA replication?", "Does the image show a region that might contain significant necrotic content, especially in rapidly growing or poorly vascularized areas?", "Is there evidence of a structure that could be growing more rapidly than the adjacent normal tissue?"], "relational": ["Is there an abnormality located in the head and neck, thorax, abdomen, pelvis, or extremities?", "Is there a structure that appears to cross anatomical barriers such as the basement membrane, blood-brain barrier, serosal membranes, or fascia?", "Is there a structure that could impact the nervous, respiratory, digestive, or endocrine system?"], "contexual_behavior": ["Does the image show a region where cells could be adapting to low oxygen by increasing glycolytic activity?", "Is there evidence of altered cell adhesion or motility in response to hormonal influence, possibly affecting metastatic potential?", "Is there a mass that seems to be disrupting the normal architecture of nearby tissue, potentially suppressing local function?"], "functions": ["Is there a visible area that could be evading immune detection, such as by lacking typical antigen presentation markers?", "Does the image show evidence of new blood vessel formation, possibly due to secretion of vascular endothelial growth factors?", "Does the image show signs of chronic inflammation, such as accumulation of inflammatory cells near a suspicious area?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure that appears denser than surrounding fat, possibly due to cellular infiltration or calcification?", "Do you see any regions with reduced water content compared to normal adipose tissue?", "Is there a visible area that looks firm or gritty in texture?"], "relational": ["Is there evidence of interaction between inflammatory cells, fibroblasts, or the extracellular matrix in fatty tissue?", "Can you see clusters of cells such as macrophages or multinucleated giant cells within fatty tissue?", "Can you identify any changes in breast or abdominal fat tissue that might indicate tissue injury?"], "contexual_behavior": [], "functions": ["Is there visual evidence of macrophage interaction with necrotic material or modulation of the inflammatory response in the tissue?", "Can you identify areas where fibrosis might be developing, such as regions with increased fibroblast activity or extracellular matrix deposition?", "Can you see signs of adipose tissue breakdown, such as regions suggestive of lipolysis or phagocytosis of fat cells?"]}}, "brain": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears swollen, which could indicate conditions like cerebral edema or infection?", "Is there evidence of shrinkage or reduced size in a structure that might be associated with aging or neurodegenerative diseases?", "Can you identify an area with decreased volume that could be related to disorders such as Alzheimer's disease or malnutrition?", "Does the image reveal abnormal lesions that might suggest multiple sclerosis, stroke, or a tumor?", "Is there visible accumulation of fluid within a structure, as seen in hydrocephalus or meningitis?", "Can you detect regions with increased iron deposition, which may occur in neurodegenerative diseases like Parkinson's disease?", "Is there a change in color, such as pallor or discoloration, that could result from hypoxia or hemorrhage?", "Does the structure appear softer than normal, possibly due to liquefactive necrosis or severe hypoxic injury?", "Is there evidence of increased firmness, which might be caused by chronic gliosis or calcification?", "Can you see plaques or deposits that are characteristic of Alzheimer's disease or demyelinating disorders?", "Are there increased white matter lesions visible, which could be associated with aging or small vessel disease?", "Does the image suggest atrophy, as seen in chronic neurodegenerative diseases or after prolonged injury?", "Is there any indication of increased intracranial pressure, such as compression or displacement of adjacent structures?", "Can you identify hemorrhages that might be due to hypertension, trauma, or coagulopathies?", "Is there evidence of abnormal electrical activity, which could be related to epilepsy or encephalopathy?", "Can you detect amyloid accumulation, as seen in Alzheimer's disease or cerebral amyloid angiopathy?", "Does the structure display abnormal tissue density, which may be present in stroke, tumors, or demyelinating diseases?", "Is there a region with altered metabolic activity, either increased or decreased, that could suggest epilepsy, tumors, or neurodegenerative diseases?", "Can you see calcifications that might be due to congenital infections, metabolic disorders, or chronic infarcts?", "Is there evidence of changes in neurotransmitter-related features, which could be associated with psychiatric disorders or Parkinson's disease?"], "properties": ["Is there a structure in the image that has an irregular, convoluted surface with visible gyri and sulci?", "Can you identify an object that appears pale grayish-pink in color?", "Does the image show a structure whose size could be approximately 15 centimeters in length and 14 centimeters in width?", "Is there an object present that could have a volume between 1,200 and 1,500 milliliters?", "Can you see a structure that is likely to contain cell types such as neurons, astrocytes, or oligodendrocytes?", "Is there evidence of a region that could contain around 86 billion neurons?", "Does the image include a structure where the number of glial cells might be roughly equal to or slightly greater than the number of neurons?", "Can you identify an object that might have a gray matter to white matter ratio of about 1.3 to 1?", "Is there a structure that could have a water content of approximately 75% to 80% by weight?", "Does the image show an object that might have a lipid content of about 10% to 12% of its wet weight?", "Is there a region that could contain myelin making up about 20% of its dry weight?", "Can you see a structure that might have a cholesterol content of 15 to 20 milligrams per gram of tissue?", "Is there an object that could have an iron concentration ranging from 30 to 60 micrograms per gram, depending on the region?", "Does the image include a structure that typically maintains a temperature between 36.5 and 38 degrees Celsius?", "Can you identify an object that would normally have a pH between 7.1 and 7.4?", "Is there a region that could consume oxygen at a rate of about 3.5 milliliters per 100 grams per minute?", "Does the image show a structure where the glucose concentration might be between 0.7 and 2.5 millimoles per liter?", "Can you see an object that would likely have a protein content of approximately 8% to 10% of its wet weight?", "Is there a structure present that could weigh between 1,300 and 1,400 grams in an adult human?"], "relational": ["Does the image show a structure that is part of the nervous system?", "Can you identify regions such as the cerebrum, cerebellum, or brainstem in the image?", "Is there a structure that connects directly to the spinal cord via the brainstem or medulla oblongata?", "Are protective membranes like the dura mater, arachnoid mater, or pia mater visible surrounding any structure?", "Does the image include blood vessels such as the internal carotid arteries or vertebral arteries supplying a central organ?", "Can you see internal cavities resembling ventricles, such as the lateral, third, or fourth ventricle?", "Is there evidence of cranial nerves, such as the optic nerve or other nerves originating from a central structure?", "Does the image show a structure protected by the bones of the cranium or skull?", "Are there areas distinguishable as gray matter or white matter within a central organ?", "Can you identify neural tissue or glial cells within any structure present?", "Is there a principal organ of the central nervous system coordinating with the spinal cord visible in the image?"], "contexual_behavior": ["Does the image show a structure that reduces its processing speed during normal aging or neurodegenerative conditions?", "Can you identify an area that would increase neural activity in response to stress via the hypothalamic-pituitary-adrenal axis?", "Is there a structure whose memory formation could be impaired by sleep deprivation affecting REM and slow-wave sleep?", "Does the image contain a region where neurotransmitter release, such as serotonin, norepinephrine, or dopamine, might be decreased in depression?", "Can you see an area that enhances synaptic plasticity during learning through mechanisms like long-term potentiation?", "Is there a structure that fails to regulate motor control in Parkinson\u2019s disease due to degeneration of dopaminergic neurons?", "Does the image show a region that would increase glucose uptake during intense mental activity?", "Can you identify a structure that reduces oxygen consumption during anesthesia as neural activity decreases?", "Is there an area that alters its function during hypoxia by shifting to anaerobic metabolism and reducing neuronal activity?", "Does the image contain a region that shows decreased responsiveness under sedation due to suppression of cortical and subcortical activity?", "Can you see a structure that increases pain perception in chronic pain conditions through central sensitization?", "Is there an area that fails to coordinate sensory input after injury when neural pathways are disrupted by trauma or stroke?", "Does the image show a region that enhances neuroprotection during mild hypothermia by reducing metabolic demand?", "Can you identify a structure that reduces executive function during aging as prefrontal cortex efficiency declines?", "Is there an area that increases neuroinflammation in neurodegenerative diseases due to activation of microglia and astrocytes?", "Does the image contain a region that alters its activity during meditation by modulating the default mode network and increasing alpha wave activity?", "Can you see a structure that shows impaired signal transmission in multiple sclerosis due to demyelination of central nervous system axons?", "Is there a region that increases blood flow during physical exercise to supply active neurons with oxygen and nutrients?", "Does the image show a structure that reduces its ability to regulate emotions in anxiety disorders due to dysregulation of limbic and prefrontal circuits?", "Can you identify an area that fails to maintain homeostasis during severe trauma when autoregulatory mechanisms are overwhelmed?"], "functions": ["Does the image contain a structure responsible for cognition and perception?", "Is there an object that controls movement by sending signals to muscles?", "Can you identify a region involved in processing sensory information?", "Does the image show structures such as the amygdala or limbic system that regulate emotions?", "Is there a visible area associated with memory formation, such as the hippocampus?", "Can you see regions like the basal ganglia or cerebellum that coordinate voluntary actions?", "Does the image include a structure that regulates hormone release through the pituitary gland?", "Is there an area related to language comprehension or production, such as Broca\u2019s or Wernicke\u2019s area?", "Can you identify a region that maintains homeostasis by adjusting bodily functions?", "Does the image show centers like the medulla oblongata or brainstem involved in regulating breathing and heart rate?", "Is there a structure supporting learning and cognition through neural plasticity?", "Can you see association areas that integrate information from multiple senses?", "Is there a region involved in regulating sleep and circadian rhythms?", "Does the image contain a structure that participates in the stress response by activating the HPA axis?", "Can you identify an area involved in decision making, such as the prefrontal cortex?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion affecting the reproductive system?", "Is there an abnormal structure involving the ovary or, in more advanced cases, the uterus or peritoneum?", "Does the image show a lesion supplied by the ovarian artery or branches of the uterine artery?"], "contexual_behavior": [], "functions": ["Can you identify a lesion that might be associated with overproduction of hormones such as estrogen or inhibin?", "Does the image contain a structure that could lead to excess estrogen secretion?", "Is there a lesion that could contribute to endometrial proliferation or signs of endometrial hyperplasia?"]}}}
[ { "answer": "close-up view of base of skull with several well shown fractures", "extracted_concepts": [ "base of skull", "fractures" ], "question": "what does this image show?" }, { "answer": "with several well shown fractures", "extracted_concepts": [ "base of skull", "fractures" ], "question": "how does this image show close-up view of base of skull?" }, { "answer": "yes", "extracted_concepts": [ "base of skull", "fractures" ], "question": "does this image show close-up view of base of skull with several well shown fractures?" }, { "answer": "no", "extracted_concepts": [ "base of skull", "amyloid angiopathy", "fractures" ], "question": "does amyloid angiopathy r. endocrine show close-up view of base of skull with several well shown fractures?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "myoma lesion" ], "question": "is myoma lesion present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basilar skull fracture" ], "question": "is basilar skull fracture present?" }, { "answer": "no", "extracted_concepts": [ "hemorrhagic corpus luteum" ], "question": "is hemorrhagic corpus luteum present?" }, { "answer": "close-up view of base of skull with several", "extracted_concepts": [ "base of skull", "fractures" ], "question": "what well shown fractures?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "several", "extracted_concepts": [ "base of skull", "close-up view", "fractures" ], "question": "how is close-up view of base of skull with shown shown fractures?" } ]	["hemorrhagic corpus luteum", "close-up view", "myoma lesion", "amyloid angiopathy", "fractures", "bone", "base of skull", "calvarium", "basilar skull fracture"]	{"hemorrhagic corpus luteum": {"yes_questions": {"contexual_properties": ["Does the image show a structure within the ovary that appears to contain blood or evidence of recent bleeding?", "Can you identify an ovarian feature that may represent a temporary endocrine gland with hemorrhagic characteristics?", "Is there a visible ovarian structure that could be involved in the menstrual cycle and shows signs of internal hemorrhage?", "Does the image contain an ovarian entity that might be responsible for progesterone production and appears to have blood-filled areas?"], "properties": ["Is there a round or oval structure measuring between 2 and 5 centimeters in diameter visible in the image?", "Can you identify an object with a reddish-brown appearance, possibly due to the presence of blood?", "Does the image show a structure with a soft and spongy texture, possibly containing areas of clot?", "Is there a cystic cavity present that contains both blood and fibrin strands?", "Can you see a structure whose wall thickness appears to be between 2 and 6 millimeters?", "Does the image reveal an object with a volume that could be estimated between 2 and 10 milliliters?", "Is there a structure composed of cell types such as luteinized granulosa cells, theca lutein cells, endothelial cells, and red blood cells?", "Can you identify an area containing both serous fluid and blood within a cystic cavity?", "Does the image show a complex cyst with mixed echogenicity and reticular internal echoes, as might be seen on ultrasound?", "Is there evidence of significant blood content, such as fresh or clotted blood, within a cystic structure?", "Can you see a structure with a thickened wall and internal fibrin strands?", "Is there an object whose average weight could be estimated between 2 and 8 grams?", "Does the image include a structure that typically persists for about 2 to 3 weeks?"], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify an object located within the ovary?", "Is there a region surrounded by ovarian cortical tissue and stroma?", "Does the image contain a structure adjacent to developing follicles or the ovarian medulla?", "Can you see blood vessels such as branches of the ovarian artery or surrounding capillaries near a particular structure?", "Is there an area containing granulosa lutein cells, theca lutein cells, and erythrocytes?", "Can you identify a structure that develops from an ovarian follicle following ovulation?", "Is there evidence of localized hemorrhage or enlargement within the ovary?", "Does the image show a structure that may interact with the endometrium or pituitary gland during the menstrual cycle?", "Is there an object contained within the pelvic cavity that fits these characteristics?"], "contexual_behavior": ["Does the image contain a structure that could represent a corpus luteum with evidence of bleeding or blood accumulation?", "Is there a visible ovarian structure that appears to have hemorrhagic features?", "Can you identify an area within the ovary that shows signs of recent or ongoing hemorrhage?", "Does the image show an ovarian entity with characteristics of both luteal tissue and blood?"], "functions": ["Does the image show a temporary ovarian structure involved in hormone secretion?", "Is there a feature present that produces progesterone and estrogen after ovulation?", "Can you identify a structure that supports the luteal phase of the menstrual cycle by preparing the endometrium for implantation?", "Is there evidence of a structure that maintains progesterone levels during early pregnancy to support the uterine lining?", "Does the image contain an object responsible for inducing secretory changes in the endometrium?", "Can you see a structure that contributes to ovarian tissue recovery at the site of follicle rupture?", "Is there a feature that plays a role in regulating hormonal balance and supporting implantation conditions?", "Does the image show a structure that prevents endometrial shedding by maintaining the uterine lining through progesterone production?"]}, "no_questions": {"contexual_properties": ["Is there increased nodularity that might be explained by fibrocystic changes, hormonal fluctuations, or benign proliferative disorders?", "Is there evidence of tenderness, such as protective posture or localized swelling, that could be explained by premenstrual syndrome, pregnancy, lactation, infection, or trauma?", "Does the image show any area with altered coloration, such as bruising or redness, that could indicate inflammation, infection, or malignancy?"], "properties": ["Is there a structure in the image that typically measures between 10 and 12 centimeters in diameter?", "Can you identify a structure whose volume could be estimated between 200 and 500 milliliters?", "Is there an area where the skin thickness could be approximately 1.5 to 2 millimeters?"], "relational": ["Does the image show ducts that could transport secretions to the surface?", "Does the image show features consistent with the presence of lactiferous ducts?", "Can you identify a region that is adjacent to the chest wall, axilla, or clavicle?"], "contexual_behavior": ["Does the image show a structure that could increase milk production in response to infant suckling?", "Is there evidence of compromised epithelial integrity that could reduce protective barrier function?", "Does the image show a structure with increased metabolic demand that might be required for sustained milk synthesis during breastfeeding?"], "functions": ["Is there a structure that might be involved in the transfer of secretory IgA to support immune development?", "Does the image show an area that acts as an endocrine organ during lactation?", "Can you see a structure that supports infant growth by supplying essential nutrients?"]}}, "close-up view": {"yes_questions": {"contexual_properties": ["Does the image reveal changes in texture that might suggest inflammation, fibrosis, or abnormal cell growth?", "Is there evidence of discoloration that could indicate bruising, jaundice, cyanosis, or localized bleeding?", "Can you observe swelling that might be due to fluid accumulation, infection, or recent trauma?", "Are there abnormal surface features such as ulceration, nodules, or irregular growths visible?", "Does the image show increased redness that could be associated with inflammation, infection, or an allergic reaction?", "Are there lesions or spots present that resemble petechiae, macules, or papules?", "Can you detect changes in moisture level, such as excessive sweating, dryness, or the presence of exudate?", "Is there visible scaling or flaking that could be related to conditions like psoriasis, eczema, or a fungal infection?", "Do you see changes in the size of any structures that might suggest hypertrophy, atrophy, or tumor formation?", "Is there abnormal pigmentation present, such as areas of depigmentation, dark patches, or post-inflammatory color changes?", "Are there areas of tissue breakdown or ulceration that could be due to infection, pressure, or poor blood supply?", "Can you observe thickened tissue that might indicate lichenification, callus formation, or chronic inflammation?", "Is there loss of normal structure suggestive of necrosis, erosion, or tissue destruction?", "Does the image show increased vascularity that could be due to new blood vessel formation, inflammation, or vascular malformations?", "Are there signs of fluid accumulation or edema that might result from increased vascular permeability, lymphatic blockage, or heart failure?"], "properties": ["Does the image display a region with high magnification, such as between 5x and 40x?", "Is there an area where small structures are shown in fine detail due to high resolution?", "Can you identify a portion of the image that covers only a limited area of the subject?", "Is there a region where only a thin plane is in sharp focus, indicating a shallow depth of field?", "Does the image contain features that appear on a millimeter or micrometer scale?", "Is there a section where the colors appear highly accurate and true to the subject?", "Can you see an area with increased contrast that helps distinguish fine details and boundaries?", "Is there a region of the image that appears especially sharp and free from distortion?", "Does any part of the image exhibit a high pixel density, resulting in crisp and detailed visualization?", "Is there evidence of bright lighting or enhanced illumination on a small area of the subject?"], "relational": ["Does the image provide a perspective where individual cells or capillaries are visible?", "Can you observe anatomical features such as cell layers or microvasculature in the depicted tissue?", "Is there evidence of glandular units or extracellular matrix in the detailed area shown?", "Does the image reveal cellular components like nuclei, mitochondria, or cell membranes?", "Can you see microscopic details while still recognizing the broader anatomical context?", "Are microstructures such as basement membrane, tight junctions, or microvilli apparent in the view?", "Does the image allow you to distinguish between tissue, cellular, and subcellular levels of organization?", "Can you identify connections between cells, such as cell junctions, intercellular bridges, or synapses?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": [], "properties": ["Is there a visible loop around the neck that appears loose, or does it show signs of being tightly wrapped?", "Does the skin beneath the looped structure on the neck appear normal, or is there any redness or indentation present?", "Can you see a cord-like structure that may contain a gelatinous substance rich in mucopolysaccharides such as hyaluronic acid and chondroitin sulfate?"], "relational": ["Is there a structure maintaining a connection between the placenta and the newborn while looping around the neck?", "Does the image show the integumentary system of the neck in contact with a cord-like structure?", "Is there a cord passing around the anterior, lateral, or posterior aspects of the newborn's neck?"], "contexual_behavior": ["Does the image show a situation where a flexible structure is wrapped around the neck of a newborn?", "Does the image depict a scenario that may be associated with perinatal complications involving the neck of a newborn?", "Can you identify any evidence of a cord-like object encircling the neck region of an infant?"], "functions": ["Is there visual evidence of increased respiratory effort or tachypnea in the newborn?", "Does the image show a newborn with signs of transient hypoxia or respiratory distress?", "Does the image suggest decreased oxygen saturation or other changes in blood gas status, such as cyanosis or abnormal skin coloration?"]}}, "myoma lesion": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure associated with the female reproductive system?", "Is there a lesion involving smooth muscle or connective tissue visible in the image?", "Can you identify an abnormality located in the uterus or cervix?", "Does the image display a mass adjacent to the endometrium, myometrium, or serosa?", "Is there a lesion present within the submucosal, intramural, or subserosal layers of the uterus?", "Can you see a structure that appears to receive blood supply from the uterine or ovarian artery?", "Is there evidence of an abnormality altering the structure of the uterine wall?", "Does the image contain a mass composed of smooth muscle cells or fibroblasts?", "Is there a lesion affecting the uterine corpus or fundus?", "Can you observe any displacement or compression of the bladder, rectum, or uterine cavity by a mass?"], "contexual_behavior": ["Does the image show a lesion whose growth rate might be higher during the reproductive years and lower after menopause?", "Is there a structure present that could impair uterine contractility during menstruation by interfering with myometrial function?", "Can you identify a lesion that may alter its vascularization or show increased angiogenesis during pregnancy?", "Does the image contain a mass that could decrease in metabolic activity following hormonal therapy with GnRH agonists?", "Is there evidence of a structure that might increase extracellular matrix production in response to estrogen stimulation?", "Can you see a lesion that could distort the uterine cavity and disrupt normal endometrial function during the menstrual cycle?", "Is there a mass that may reduce its ability to promote angiogenesis after menopause due to lower estrogen levels?", "Does the image show a lesion that could increase inflammatory signaling and local cytokine release during tissue injury or degeneration?", "Can you identify a structure that might impair fertility by altering the uterine environment or distorting the endometrial cavity?", "Is there a lesion that could increase its secretion of growth factors in response to progesterone, supporting cellular proliferation?", "Does the image show a mass whose proliferation might be reduced after treatment with GnRH agonists?", "Can you see a lesion that could alter uterine blood flow during pregnancy due to increased vascular demand and hormonal changes?", "Is there evidence of a structure that might increase fibrotic activity and collagen deposition under chronic inflammation?", "Does the image contain a lesion whose functional impact could decrease after surgical intervention such as myomectomy or ablation?"], "functions": ["Does the image show a benign growth within the uterus that could disrupt normal smooth muscle architecture?", "Is there evidence of a uterine mass that might impair contractility of the uterine wall?", "Can you identify a lesion that could be responsible for abnormal or heavy menstrual bleeding?", "Does the image contain a structure that might distort the uterine cavity and potentially interfere with embryo implantation?", "Is there a mass present that could alter the uterus's responsiveness to estrogen or progesterone?", "Can you see a lesion that might cause pelvic pain or exert pressure on nearby pelvic organs?", "Is there a structure that could disrupt normal endometrial function or cause local inflammation?", "Does the image show a mass that might affect the vascular supply of the uterus, such as by compressing blood vessels or promoting abnormal angiogenesis?", "Can you identify a lesion interacting with adjacent uterine tissues by compressing or displacing the myometrium or endometrium?", "Is there evidence of abnormal uterine growth due to proliferation of smooth muscle cells and extracellular matrix?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of a disease process where cyst shedding in stool could last from 1 to 4 weeks?", "Is there any indication of liver enzyme elevation, with ALT or AST values in the range of 50 to 200 IU/L?", "Can you identify signs of a disease where the typical number of bowel movements per day ranges from 3 to 10?"], "relational": ["Does the image suggest that the portal vein or mesenteric blood vessels are involved in a pathological process?", "Does the image display any abnormalities in the colon or liver?", "Does the image show evidence of a condition primarily impacting the digestive or hepatic systems?"], "contexual_behavior": [], "functions": ["Can you detect signs of immune evasion, such as reduced immune cell activity or absence of complement activation in affected tissues?", "Is there visible disruption or damage to the intestinal mucosa that could indicate impaired motility?", "Can you identify regions where the mucosal barrier appears disrupted or where ulcer formation is present?"]}}, "amyloid angiopathy": {"yes_questions": {"contexual_properties": ["Does the image show blood vessels with evidence of abnormal protein accumulation within their walls?", "Can you identify vessels that appear thickened due to material infiltrating the vascular layers?", "Is there visual evidence of vessel wall thickening that could be attributed to infiltration of abnormal substances?", "Do any vessels appear narrowed, possibly due to deposits encroaching on the lumen?", "Can you see blood vessels that display discoloration or abnormal staining patterns?", "Are there vessels that show signs of calcification, suggesting chronic deposition of abnormal material?", "Is there evidence of small hemorrhages or microbleeds associated with fragile vessel walls?", "Do any vessels appear to have altered composition, such as loss of normal smooth muscle structure?", "Can you identify vessels that seem less elastic or more rigid than expected?", "Are there vessels that exhibit abnormal staining with dyes commonly used to detect protein deposits, such as Congo red?", "Do any vessels appear to have increased permeability or signs of endothelial dysfunction?", "Is there visual evidence of changes in vessel diameter or architecture that could be due to abnormal material accumulation?", "Can you see signs of vessel stiffening or rigidity that might result from infiltration of non-native proteins?", "Are there vessels where the normal vascular components seem to be replaced by other material?", "Do any vessels show features consistent with the accumulation of amyloid-beta within their walls?"], "properties": [], "relational": ["Does the image show evidence of a pathological process affecting the central nervous system?", "Can you identify abnormalities involving small- to medium-sized blood vessels, such as cerebral arteries or arterioles?", "Is there visible involvement of the cerebral cortex or leptomeninges?", "Does the image display changes in the lobar regions of the brain, such as the occipital, parietal, or frontal lobes?", "Can you see signs of vascular dysfunction due to amyloid deposition in blood vessels of the brain?", "Are there alterations in structures adjacent to affected vessels, such as the brain parenchyma or perivascular spaces?", "Is there evidence of amyloid-beta accumulation, particularly the A\u03b240 or A\u03b242 isoforms, within vascular walls?", "Can you identify vessels containing endothelial cells, smooth muscle cells, or pericytes that appear abnormal?", "Does the image suggest features consistent with cerebral small vessel disease or neurodegeneration?", "Are there visible interactions between affected vessels and other vascular structures like capillaries or venules in the cerebral circulation?"], "contexual_behavior": [], "functions": ["Does the image show evidence of vascular dysfunction in the brain, such as impaired vessel integrity or signs of hemorrhage?", "Can you identify features consistent with vessel narrowing or obstruction that could reduce cerebral blood flow?", "Is there visual evidence of amyloid deposition within cerebral vessels?", "Does the image display signs of weakened vessel walls or the presence of microaneurysms?", "Can you observe any structural disruption of blood vessels that might indicate increased vascular permeability or barrier breakdown?", "Is there evidence of smooth muscle cell loss or abnormal accumulation within the tunica media or adventitia of vessels?", "Does the image reveal fragile-appearing vessels or microbleeds that could suggest a risk of hemorrhagic stroke?", "Can you see indications of impaired perivascular drainage, such as accumulation of metabolic waste or perivascular blockage?", "Is there evidence of hypoxic or ischemic changes in brain tissue that could result from vascular alterations?", "Does the image suggest reduced cerebral perfusion or impaired vascular reactivity?", "Are there signs of microglial activation or inflammatory changes associated with vascular inflammation?"]}, "no_questions": {"contexual_properties": [], "properties": ["Are there cells that appear pale eosinophilic or light pink under the microscope?", "Are there cells that might express proteins like cytokeratin 7, cytokeratin 19, or epithelial cell adhesion molecule?", "Can you see cells with moderate mitochondrial content, suggesting active transport or secretion?"], "relational": ["Can you identify regions such as portal tracts or the biliary tree containing specialized cells?", "Does the image show cells participating in bile transport or secretion?", "Can you see anatomical connections to features like the Canals of Hering or portal triads?"], "contexual_behavior": [], "functions": ["Is there a visible epithelial lining that could provide structural support or form tight junctions?", "Is there a visible interaction between the duct lining and neighboring hepatocytes or Kupffer cells?", "Does the image suggest the presence of cells contributing to extracellular matrix production in the bile duct region?"]}}, "fractures": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a disruption in the integrity of a structure that could be part of the musculoskeletal system?", "Can you identify any abnormality affecting long bones such as the femur, radius, or tibia?", "Is there evidence of a condition that might compromise mobility or structural support in the appendicular or axial skeleton?", "Does the image display changes in areas near joints like the knee, elbow, hip, or wrist?", "Can you see any involvement of anatomical landmarks such as the epiphysis, diaphysis, metaphysis, or articular surface?", "Is there a visible alteration in regions surrounded by muscle tissue, connective tissue, blood vessels, or skin?", "Does the image suggest an impact on organ systems like the circulatory or nervous system adjacent to a skeletal abnormality?", "Are there signs of stabilization by structures such as ligaments, muscles, periosteum, or external fixation devices?", "Can you detect abnormalities in bones that are weight-bearing or appear osteoporotic?", "Is there visual evidence of disruption near anatomical structures like blood vessels or nerves adjacent to a skeletal region?"], "contexual_behavior": [], "functions": ["Does the image show an area where bone continuity is lost, potentially compromising structural support?", "Can you identify a region where skeletal stability appears disrupted, possibly affecting weight bearing or mobility?", "Is there visual evidence of biological processes such as inflammation or callus formation at a site of bone injury?", "Does the image reveal signs of hematoma formation or accumulation of inflammatory cells near a bone defect?", "Can you see features suggesting debris clearance or recruitment of repair cells at a site of tissue regeneration?", "Is there an area where local blood vessels may be disrupted, leading to reduced perfusion or impaired healing?", "Does the image show a structure that could represent a stabilizing callus or scaffold for new bone growth?", "Can you identify regions where immature bone is being replaced by more organized lamellar bone, indicating structural restoration?", "Is there visual evidence of cellular activity, such as bone matrix synthesis or resorption, contributing to restoration of bone integrity?", "Does the image suggest impaired function of nearby muscles or joints, such as restricted movement or joint stiffness?", "Can you see signs of new bone matrix being formed or damaged bone being resorbed, indicating coordinated bone turnover?", "Is there evidence of progressive mineralization or tissue remodeling that would restore mechanical strength to the bone?", "Does the image suggest the influence of regulatory mechanisms, such as growth factors or cytokines, in the healing process?", "Can you identify features consistent with immobilization, such as maintained bone alignment or restricted movement at the injury site?", "Is there visual indication of nutrient or oxygen delivery supporting tissue repair in the area of bone injury?"]}, "no_questions": {"contexual_properties": ["Can you identify a region that appears distinct from surrounding tissue and may suggest secondary involvement by a pathological process?", "Is there a visible lesion that differs in appearance from normal tissue and could represent a distant manifestation of a primary condition elsewhere in the body?", "Does the image show any abnormal area that could indicate the spread of disease from another primary site?"], "properties": [], "relational": ["Can you identify a mass or lesion that appears to have formed through hematogenous or lymphatic spread, or by direct extension?", "Can you identify a lesion in the bone, liver parenchyma, lung parenchyma, brain tissue, or lymph nodes?", "Is there a region in the image that could be associated with secondary involvement from cancers such as breast, lung, prostate, colorectal carcinoma, or melanoma?"], "contexual_behavior": ["Does the image show an area that could represent abnormal tissue growth distinct from surrounding structures?", "Can you identify a lesion that is visually distinct and may indicate the presence of disease spread from another location?", "Is there a region that appears different in texture or color compared to adjacent tissues, suggesting a pathological process?"], "functions": ["Is there a visible mass that could represent a secondary site of tumor growth, distinct from the primary lesion?", "Is there a region that appears to be undergoing rapid cell proliferation or expansion?", "Can you see features that might indicate the activation of abnormal signaling pathways within a mass or lesion?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Does the image show an increased number of cells that might indicate infection or inflammation?", "Are there cells exhibiting cytoplasmic vacuolization, which could be a sign of sepsis or toxic states?", "Can you identify cells with increased volume, which may occur during activation or blast transformation?"], "properties": ["Can you observe cells with different nuclear-to-cytoplasmic ratios, such as some with a high ratio and others with a lower ratio?", "Are there cells present that contain cytoplasmic granules, as well as others that lack prominent granules?", "Can you see different types of blood cells such as neutrophils, lymphocytes, monocytes, eosinophils, or basophils?"], "relational": ["Does the image show any components of the immune system?", "Is there evidence of monocytes, eosinophils, or basophils present?", "Does the image include tissue where blood cells are produced, such as bone marrow?"], "contexual_behavior": [], "functions": ["Does the image show cells that are involved in defending the body against pathogens?", "Is there evidence of an inflammatory response that could be due to autoimmune activity, such as cells targeting the body\u2019s own tissues?", "Are there cells that appear to be regulating immune responses, potentially through cytokine secretion or suppressive activity?"]}}, "base of skull": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a region formed by bones such as the occipital, sphenoid, temporal, ethmoid, or frontal bones?", "Can you identify areas corresponding to the anterior, middle, or posterior cranial fossae?", "Is there evidence of large openings like the foramen magnum or smaller foramina such as the jugular foramen, foramen ovale, or hypoglossal canal?", "Does the image depict pathways for cranial nerves or major blood vessels?", "Can you see structures that support the frontal lobes, temporal lobes, cerebellum, or brainstem?", "Is there a visible floor of the cranial cavity that separates the brain from other regions?", "Does the image suggest the presence of nerves such as the olfactory, optic, or trigeminal nerves traversing through bony openings?", "Can you identify blood vessels like the internal carotid artery, vertebral artery, jugular vein, or basilar artery in relation to bony structures?", "Is there a region adjacent to the neck, nasal cavity, oral cavity, pharynx, or vertebral column?", "Does the image show attachment points for membranes such as the dura mater, arachnoid mater, or pia mater?"], "contexual_behavior": ["Does the image show evidence of a region where neural structures might be at increased risk of injury following trauma?", "Is there a visible area where a fracture could potentially disrupt the function of cranial nerves passing through foramina?", "Can you identify any features that might suggest impaired cerebrospinal fluid drainage due to obstruction or herniation?", "Does the image reveal any defects that could allow pathogens to enter the cranial cavity from the paranasal sinuses or middle ear?", "Is there a region where tumor invasion could encase or compress major blood vessels, potentially affecting vascular flow?", "Can you see any signs of disrupted bone integrity that would reduce the ability to absorb shock from high-impact injury?", "Does the image display any anatomical variations or malformations that might compromise structural support and lead to instability?", "Are there features suggesting narrowed sinus ostia or drainage pathways that could impair normal sinus drainage?", "Can you identify any pathways by which infection from the middle ear could extend to the petrous part of the temporal bone or inner ear structures, potentially affecting hearing?", "Is there evidence of unsealed dural or bony defects that could result in cerebrospinal fluid leakage after surgical intervention?"], "functions": ["Is there a structure in the image that provides a rigid platform supporting the brain?", "Can you identify an area that acts as a barrier separating the cranial cavity from facial or neck regions?", "Does the image show any features that serve as passageways for cranial nerves or blood vessels between the brain and peripheral areas?", "Is there a region that contains foramina or canals for nerve and vascular conduits?", "Can you see any attachment points for muscles involved in chewing or swallowing?", "Does the image include a structure that encases and protects cranial nerves as they exit or enter the cranial cavity?", "Is there evidence of a region contributing to the overall stability and shape of the head by connecting cranial bones?", "Can you identify an area involved in transmitting sound vibrations through the temporal bone to the inner ear?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a structure with an irregular or lobulated shape?", "Does the tissue display a pink to eosinophilic appearance under the microscope?", "Can you see a lesion composed mainly of apocrine epithelial cells surrounded by myoepithelial cell layers?"], "relational": ["Can you identify a proliferative lesion associated with the mammary gland system?", "Is there evidence of a lesion adjacent to terminal duct lobular units or surrounded by breast stroma?", "Is there a lesion supported by fibrous stroma or a collagenous matrix?"], "contexual_behavior": ["Can you identify structures that might exhibit altered hormone responsiveness, such as changes in estrogen or androgen receptor expression?", "Can you see areas where normal apocrine function appears reduced, possibly due to hormonal changes like menopause or endocrine therapy?", "Does the image show a region with increased cellular proliferation that could be associated with hormonal stimulation or proliferative breast disease?"], "functions": ["Does the image reveal areas where the normal ductal or lobular architecture appears distorted or dominated by a single cell type?", "Can you see signs of stromal changes or mild inflammation surrounding certain lobules in the breast tissue?", "Does the image contain breast tissue where typical epithelial cells appear to be replaced by cells with atypical apocrine features?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Are there areas that might be more painful to touch, potentially due to exposed nerve endings or intensified inflammation?", "Can you identify regions that have decreased in size, possibly indicating effective treatment or natural healing?", "Are there hardened regions that could be due to fibrosis, calcification, or chronic inflammation?"], "properties": ["Is there a region affecting a surface area greater than 10 cm\u00b2 or involving multiple contiguous regions?", "Does the image contain a region with indistinct, irregular, or poorly demarcated borders?", "Can you see an area with a heterogeneous texture, such as roughness, firmness, or ulceration?"], "relational": ["Does the image show involvement of structures like lymphatic vessels or surrounding organs next to a damaged area?", "Can you see evidence of tissue remodeling at the interface of a large abnormal region?", "Does the image show an area where both epithelial and connective tissues appear affected?"], "contexual_behavior": [], "functions": ["Is there an area where tissue regeneration seems impaired, possibly due to stem cell loss or disruption of the extracellular matrix?", "Does the image display regions where metabolic activity could be compromised, such as areas with reduced cellular viability or impaired nutrient exchange?", "Are there indications of barrier breakdown, such as loss of protective tissue layers or increased vulnerability to external factors?"]}}, "basilar skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a fracture involving the base of the skull, particularly in bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Is there a fracture line at the cranial base that appears less than a few millimeters wide?", "Does the image reveal a break limited to the thickness of the cranial base bones, typically only a few millimeters deep?", "Can you see a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Is there a lucent line traversing the base of the skull visible on the image?", "Does the image show an air-fluid level or evidence of pneumocephalus near the base of the skull?", "Can you identify any signs of cerebrospinal fluid leakage in association with a skull base fracture?", "Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Does the image suggest a unilateral fracture at the base of the skull, rather than a bilateral one?", "Is the temporal bone involved in the observed skull base fracture?", "Can you estimate whether the displacement of the fracture at the skull base is minimal, less than 2 millimeters?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?", "Are there air-fluid levels present near the base of the skull, as seen in about 20% to 30% of such fractures?", "On CT imaging, is there a hypodense (lucent) line at the base of the skull relative to the surrounding bone?", "Can you observe bruising patterns such as blue or purple discoloration behind the ear or around the eyes, which may change to yellow-green as they resolve?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Can you identify abnormalities in the anterior, middle, or posterior cranial fossae?", "Is there any indication of injury near the course of cranial nerves like the olfactory, optic, or facial nerves?", "Does the image reveal changes involving foramina such as the foramen magnum or cribriform plate?", "Are there visible alterations adjacent to the inner ear, nasal cavity, or orbit?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?", "Is there evidence of communication between the cranial cavity and spaces such as the subarachnoid space or paranasal sinuses?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Are there signs of disruption in sinuses such as the sphenoid or ethmoid sinus?", "Can you identify exposure or compromise of anatomical pathways like cerebrospinal fluid pathways or the auditory canal?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a disruption in the structural integrity of the skull base that could compromise brain protection?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Can you identify features suggesting a breach between the nasal cavity and cranial cavity, such as a defect in the cribriform plate?", "Does the image reveal any signs that could explain cranial nerve deficits, such as those affecting facial movement, hearing, vision, or swallowing?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?", "Can you see any indications that might increase the risk of infection entering the central nervous system, such as a direct pathway for pathogens?", "Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Are there features present that could facilitate the development of a cerebrospinal fluid leak due to openings in the dura mater or bone?", "Is there any sign of functional impairment, such as altered consciousness, seizures, or focal neurological deficits, that could be explained by a structural abnormality at the skull base?"]}, "no_questions": {"contexual_properties": ["Does the image show a tortuous vessel, which could be related to hypertension or vessel wall weakness?", "Does the image show a vessel-like structure with an altered diameter, such as dilation or constriction?", "Is there a thickened lining visible in a vessel, possibly due to chronic irritation or hyperplasia?"], "properties": ["Is there any feature in the image that cannot be described by physical properties such as length, width, or thickness?", "Can you identify an aspect in the image that is not associated with color, shape, or texture?", "Can you find something in the image that is described by a term rather than by its physical appearance or structure?"], "relational": ["Is there a structure such as an intestine, blood vessel, urethra, or esophagus that appears to maintain anatomical continuity through an open channel?", "Can you identify an organ such as the heart, lungs, kidneys, intestines, or bladder with a visible open lumen?", "Does the image include a component of the circulatory, respiratory, or gastrointestinal system that relies on an open passage for function?"], "contexual_behavior": ["Is there a case where the incentive for innovation has decreased after full disclosure, allowing competitors to use the disclosed information post-expiration?", "Does the image suggest that exclusive rights are not recognized in certain regions due to territorial limitations or lack of jurisdiction?", "Is there an indication of unauthorized use occurring during ongoing litigation, possibly due to the absence of a preliminary injunction?"], "functions": ["Is there evidence of a channel or lumen that is maintained in an open state to support physiological function?", "Does the image show a structure that appears open and unobstructed, allowing for normal passage or flow?", "Is there a feature in the image that would support homeostasis by ensuring unobstructed transport within the body?"]}}}
[ { "answer": "close-up view of lesions slide which is brain from case", "extracted_concepts": [ "brain", "lesions slide" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "close-up view", "brain", "lesions slide" ], "question": "does this image show close-up view of lesions slide which is brain from this case?" }, { "answer": "no", "extracted_concepts": [ "inflamed exocervix", "close-up view", "brain", "lesions slide" ], "question": "does inflamed exocervix show close-up view of lesions slide which is brain from this case?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "focal hemorrhagic infarction" ], "question": "is focal hemorrhagic infarction well shown present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basilar skull fracture" ], "question": "is basilar skull fracture present?" }, { "answer": "no", "extracted_concepts": [ "alpha smooth muscle actin immunohistochemical" ], "question": "is alpha smooth muscle actin immunohistochemical present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" } ]	["close-up view", "lesions slide", "bone", "focal hemorrhagic infarction", "inflamed exocervix", "basilar skull fracture", "alpha smooth muscle actin immunohistochemical", "calvarium", "brain"]	{"close-up view": {"yes_questions": {"contexual_properties": ["Does the image reveal changes in texture that might suggest inflammation, fibrosis, or abnormal cell growth?", "Is there evidence of discoloration that could indicate bruising, jaundice, cyanosis, or localized bleeding?", "Can you observe swelling that might be due to fluid accumulation, infection, or recent trauma?", "Are there abnormal surface features such as ulceration, nodules, or irregular growths visible?", "Does the image show increased redness that could be associated with inflammation, infection, or an allergic reaction?", "Are there lesions or spots present that resemble petechiae, macules, or papules?", "Can you detect changes in moisture level, such as excessive sweating, dryness, or the presence of exudate?", "Is there visible scaling or flaking that could be related to conditions like psoriasis, eczema, or a fungal infection?", "Do you see changes in the size of any structures that might suggest hypertrophy, atrophy, or tumor formation?", "Is there abnormal pigmentation present, such as areas of depigmentation, dark patches, or post-inflammatory color changes?", "Are there areas of tissue breakdown or ulceration that could be due to infection, pressure, or poor blood supply?", "Can you observe thickened tissue that might indicate lichenification, callus formation, or chronic inflammation?", "Is there loss of normal structure suggestive of necrosis, erosion, or tissue destruction?", "Does the image show increased vascularity that could be due to new blood vessel formation, inflammation, or vascular malformations?", "Are there signs of fluid accumulation or edema that might result from increased vascular permeability, lymphatic blockage, or heart failure?"], "properties": ["Does the image display a region with high magnification, such as between 5x and 40x?", "Is there an area where small structures are shown in fine detail due to high resolution?", "Can you identify a portion of the image that covers only a limited area of the subject?", "Is there a region where only a thin plane is in sharp focus, indicating a shallow depth of field?", "Does the image contain features that appear on a millimeter or micrometer scale?", "Is there a section where the colors appear highly accurate and true to the subject?", "Can you see an area with increased contrast that helps distinguish fine details and boundaries?", "Is there a region of the image that appears especially sharp and free from distortion?", "Does any part of the image exhibit a high pixel density, resulting in crisp and detailed visualization?", "Is there evidence of bright lighting or enhanced illumination on a small area of the subject?"], "relational": ["Does the image provide a perspective where individual cells or capillaries are visible?", "Can you observe anatomical features such as cell layers or microvasculature in the depicted tissue?", "Is there evidence of glandular units or extracellular matrix in the detailed area shown?", "Does the image reveal cellular components like nuclei, mitochondria, or cell membranes?", "Can you see microscopic details while still recognizing the broader anatomical context?", "Are microstructures such as basement membrane, tight junctions, or microvilli apparent in the view?", "Does the image allow you to distinguish between tissue, cellular, and subcellular levels of organization?", "Can you identify connections between cells, such as cell junctions, intercellular bridges, or synapses?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure in the image that appears to arise from epithelial, connective, muscle, or nervous tissue?", "Can you identify an abnormal mass affecting organs such as the lung, liver, kidney, ovary, or colon?", "Is there a structure associated with regional lymph nodes, lymphatic vessels, or the thoracic duct?"], "contexual_behavior": [], "functions": ["Does the image show evidence of blood vessels being compressed or invaded, possibly leading to reduced blood flow or congestion?", "Can you identify an area where normal tissue architecture seems disrupted or invaded by an abnormal mass?", "Does the image suggest reduced nutrient supply or oxygenation to tissues adjacent to a large mass, such as signs of hypoxia or necrosis?"]}}, "lesions slide": {"yes_questions": {"contexual_properties": ["Does the image show areas where tissue expansion suggests tumor progression or inflammation?", "Can you identify regions with multiple distinct abnormal foci, indicating multifocal disease or possible metastasis?", "Are there any areas with color changes that might reflect hemorrhage or necrosis within the tissue?", "Do you observe abnormal regions with irregular borders, which could indicate malignancy or invasive growth?", "Is there evidence of abnormal areas with pale or empty centers, suggesting necrosis or ischemia?", "Can you see regions with increased cellular density, possibly due to hyperplasia, neoplasia, or inflammation?", "Are there abnormal areas containing blood or hemorrhagic zones, which may result from vascular injury or tumor invasion?", "Do you notice any abnormal regions with granular or dense deposits that could represent calcification?", "Is there evidence of fibrous tissue or scarring within abnormal regions, suggesting chronic injury or collagen deposition?", "Can you identify areas with a dense infiltrate of inflammatory cells, indicating an active immune response or infection?", "Are there abnormal regions with clear spaces or swelling, which could be due to edema or fluid accumulation?", "Do you observe disruption of normal tissue patterns, suggesting neoplastic or dysplastic changes?", "Is there an increased number of mitotic figures within abnormal regions, reflecting heightened proliferation or malignancy?", "Can you see areas where the tissue surface is lost or eroded, indicating ulceration or chronic inflammation?", "Are there abnormal regions with pigment accumulation, such as melanin, hemosiderin, or lipofuscin?", "Do you observe abnormal areas that have decreased in size, possibly reflecting a response to treatment?", "Is there evidence of fluid-filled spaces within abnormal regions, suggesting cystic changes or degeneration?", "Can you identify abnormal regions with increased numbers of blood vessels, indicating angiogenesis or vascular proliferation?", "Are there cells with multiple nuclei or giant cells present within abnormal regions, suggesting cell fusion or abnormal mitosis?", "Do you observe changes in the extracellular matrix within abnormal regions, such as increased fibrosis or matrix remodeling?"], "properties": ["Is there an object in the image that appears to be a smooth, polished rectangle?", "Can you identify a transparent or colorless item, possibly with a frosted end?", "Does the image show something with approximate dimensions of 75 mm by 25 mm?", "Is there a structure that seems to be about 1 mm thick?", "Can you see an object that could be made of soda-lime glass or borosilicate glass?", "Is there an item present that would weigh around 5 grams?", "Does the image contain a rectangular object with high optical clarity suitable for microscopy?", "Can you spot something with a surface area close to 1875 square millimeters?", "Is there an object that could accommodate up to 3\u20135 tissue samples?", "Can you see an item that would have negligible water absorption due to its glass composition?", "Is there a structure that would be highly resistant to most laboratory reagents except hydrofluoric acid?", "Does the image include an object with a refractive index typical of glass, around 1.52?"], "relational": ["Does the image include tissue that could be associated with the integumentary, respiratory, gastrointestinal, or nervous systems?", "Can you identify regions in the image that appear to be composed of epithelial, connective, muscle, or nervous tissue?", "Is there a structure present that could represent skin, lymph nodes, mucosa, or an organ?", "Does the tissue in the image seem to originate from areas such as the skin, lungs, liver, brain, or gastrointestinal tract?", "Are there visible cellular components such as epithelial cells, inflammatory cells, neoplastic cells, or stromal cells?", "Can you see evidence that the tissue was obtained through biopsy or resection?", "Is there any indication that this specimen could be part of a larger pathological collection, such as a case series or biorepository?", "Does the image show features consistent with neoplastic, inflammatory, infectious, or degenerative lesions?", "Are there adjacent slides or specimens, such as control slides or immunohistochemistry slides, visible in the image?", "Can you identify anatomical features such as cellular architecture, tissue boundaries, vascular structures, or invasion patterns?"], "contexual_behavior": ["Does the image show evidence of increased cellular activity that could indicate inflammation or immune cell recruitment?", "Can you identify features suggesting impaired tissue repair, such as abnormal or incomplete healing, possibly related to chronic disease?", "Is there a noticeable reduction in immune cell infiltration that might be consistent with immunosuppressed states or lymphocyte deficiency?", "Are there visible signs of new blood vessel formation that could suggest angiogenesis in response to low oxygen levels?", "Does the image display areas where cell death appears reduced, potentially indicating increased cell survival during tumor progression?", "Can you observe excessive or disorganized deposition of matrix proteins, such as collagen, that might point to extracellular matrix remodeling in fibrotic conditions?", "Is there evidence of widespread cell death that could be attributed to acute injury or necrosis?", "Does the tissue appear to have diminished regenerative capacity, such as reduced cell proliferation or repair, which could be associated with aging?", "Are there visible clusters of microorganisms or signs of microbial infiltration that would indicate heightened pathogen presence during infection?", "Can you detect a reduced inflammatory response, such as fewer immune cells or suppressed cytokine activity, possibly following corticosteroid treatment?", "Is there evidence of poor blood vessel formation or maintenance that could suggest impaired vascularization in the context of diabetes?", "Does the image show a high frequency of cell division among atypical cells, which might be consistent with increased mitotic activity during malignant transformation?", "Are there indications of reduced phagocytic activity, such as an accumulation of debris or pathogens, that could be linked to immunodeficiency?", "Can you identify abnormal patterns of cellular maturation or differentiation that might be associated with genetic disorders?", "Is there excessive accumulation of fibrous connective tissue that could indicate increased fibrosis following repeated tissue injury?"], "functions": ["Does the image show a sample prepared for microscopic examination to aid in tissue analysis or medical diagnostics?", "Can you identify evidence of cellular or structural abnormalities that might indicate a pathological process?", "Is there visual information that could be used to monitor changes in tissue over time, such as for assessing disease progression?", "Does the image reveal alterations in cellular morphology or lesion characteristics that could reflect a response to therapy?", "Are there features such as atypical cells, increased mitotic figures, or areas of necrosis visible, suggesting abnormal cellular activity?", "Can you observe signs of tissue repair, fibrosis, or new tissue formation that might indicate healing or regeneration?", "Does the image provide visual cues that could help distinguish between benign and malignant lesions, such as evidence of invasion or high mitotic rate?", "Are there patterns of growth, invasion, or cellular differentiation visible that could inform about the biological behavior of a lesion?", "Is there histopathological information present that could support clinical decision-making or guide lesion management?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show neighboring tissues like pericolic fat, lymphatic vessels, or blood vessels adjacent to abnormal regions?", "Does the image show tissue layers such as mucosa, submucosa, muscularis propria, or serosa?", "Is there a loss of normal colonic mucosal architecture replaced by dysplastic glands?"], "contexual_behavior": [], "functions": ["Is there a visible reduction in mucin production or evidence of abnormal secretory function within glandular structures?", "Does the image display features that suggest resistance to programmed cell death, such as persistent abnormal cell clusters?", "Does the image show areas where normal glandular architecture is lost and replaced by irregular structures?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show an abnormal mass within the respiratory system?", "Does the abnormality appear to be bounded by lung parenchyma, pleural surface, or bronchial walls?", "Can you see an area with increased inflammatory cell presence within the thoracic cavity?"], "contexual_behavior": [], "functions": ["Is there a region that might be inducing angiogenesis, as indicated by new or irregular blood vessel formation?", "Is there visual evidence of vascular remodeling or abnormal blood supply associated with a mass?", "Is there evidence of immune cell infiltration or changes in immune activity near a suspicious mass?"]}}, "focal hemorrhagic infarction": {"yes_questions": {"contexual_properties": ["Is there a region in the image that appears enlarged or swollen, suggesting expansion due to edema and hemorrhage in the acute phase?", "Can you identify an area that decreases in size, possibly indicating resolution of edema and tissue resorption in the subacute or chronic phases?", "Does the image show a focus that appears more edematous or swollen, potentially following vascular injury and disruption of the blood-brain barrier?", "Is there evidence of increased bleeding in a region that could be due to reperfusion of previously ischemic tissue or ongoing vascular injury?", "Can you observe a color change in a lesion, such as a transition from red to yellow-brown, which might indicate hemoglobin breakdown and accumulation of hemosiderin or bilirubin?", "Is there a region that appears necrotic, possibly reflecting tissue death shortly after an ischemic insult?", "Does the image show an area that becomes more liquefied, suggesting enzymatic digestion of dead tissue during the subacute phase?", "Can you see signs of increased iron deposition, such as hemosiderin accumulation, in a region where red blood cells may have broken down?", "Is there a focus that appears firmer, possibly due to replacement of necrotic debris by fibrous tissue in the chronic phase?", "Does the image reveal a cavity within a lesion, which could result from removal of liquefied necrotic tissue by phagocytes in the late chronic phase?", "Can you identify increased infiltration of inflammatory cells in a region during the early or subacute phases, suggesting an immune response to tissue injury?", "Is there a visible change in texture of a lesion, such as softening during liquefaction or firming with fibrosis, over time?", "Does the image show evidence of macrophage activity, such as accumulation of hemosiderin from phagocytosis of red blood cell breakdown products?", "Can you observe increased organization by fibrous tissue in a region, possibly due to fibroblast proliferation during the chronic reparative phase?", "Is there swelling of tissue surrounding a lesion, which could be due to vasogenic edema in the acute phase?", "Does the image demonstrate increased mass effect in a region, potentially caused by pronounced edema and hemorrhage in the early stages?", "Is there evidence of blood-brain barrier breakdown in a region during the acute phase following vascular injury?", "Can you identify increased contrast enhancement on imaging in an area where the blood-brain barrier may be disrupted?", "Does the image show decreased perfusion in a region immediately after a vascular occlusion?", "Is there a rare finding of calcification within a lesion, possibly indicating dystrophic calcification in necrotic tissue during the late chronic stage?"], "properties": ["Is there a region in the image that measures between 1 and 5 centimeters in diameter?", "Can you identify an area with an irregular or wedge-shaped outline?", "Does the image show a region that appears dark red or purple?", "Is there a localized area that seems to contain several milliliters of blood?", "Can you see a region composed of necrotic tissue, red blood cells, and inflammatory cells?", "Is there evidence of locally increased hemoglobin concentration in any part of the image?", "Does the image reveal an area with increased water content, possibly due to edema?", "Is there a region that appears denser than the surrounding tissue, suggesting blood accumulation?", "Can you identify a hyperdense or hyperintense area with surrounding edema on the imaging study?", "Does the image contain a region where red blood cells, neutrophils, macrophages, and necrotic cells are present?", "Is there a lesion that appears to be acute or subacute, possibly only hours to a few days old?", "Can you see evidence of increased iron or hemosiderin deposition in any region?", "Is there an area where the tissue pH is likely decreased, possibly below 7.0 due to ischemia?", "Does the image show a region with a soft, friable texture?", "Is there a localized increase in protein content from plasma proteins or cellular breakdown products?"], "relational": ["Does the image show a region within the central nervous system, cardiovascular system, or gastrointestinal system that appears abnormal?", "Can you identify an area in the brain, lungs, or intestines that looks different from the surrounding tissue?", "Is there a localized zone where parenchymal or vascular tissue appears disrupted?", "Does the image contain evidence of necrotic tissue interspersed with areas of hemorrhage?", "Can you see a region where tissue necrosis is surrounded by relatively healthy parenchyma?", "Is there a visible area with an accumulation of red blood cells outside of normal vessels?", "Does the image show a structure bordered by viable tissue and blood vessels?", "Can you identify an area with signs of edema or inflammatory infiltration within an organ such as the brain, lungs, heart, or intestines?", "Is there a localized region where arterioles, capillaries, or venules appear disrupted or occluded?", "Does the image reveal a zone with both necrotic cells and inflammatory cells present?", "Can you see evidence of vascular occlusion or reperfusion injury in a specific anatomical region?", "Is there a focal area where hemorrhage is present within otherwise healthy tissue?"], "contexual_behavior": ["Does the image show an area where local tissue perfusion appears severely impaired, possibly due to extensive vascular rupture and significant hemorrhage?", "Can you identify a region with signs of blood extravasation that might trigger an increased inflammatory response in the surrounding tissue?", "Is there evidence of disrupted vascular function, such as compromised vessel integrity or obstruction of microcirculation, in any part of the image?", "Does the image reveal hemorrhagic damage overlapping with regions of high neuronal density, potentially leading to extensive neuronal dysfunction?", "Can you see an area where tissue recovery after ischemic injury might be limited due to exacerbated cellular necrosis and impaired reparative processes?", "Is there a region where blood breakdown products and inflammation could be causing secondary edema formation by disrupting vascular permeability?", "Does the image show signs of vascular congestion or tissue swelling that might impair the clearance of metabolic waste from the affected region?", "Can you identify a location where endothelial damage and inflammatory mediator release may have disrupted the blood-brain barrier?", "Is there evidence of ongoing bleeding that could overwhelm local hemostatic mechanisms, such as impaired clot formation or platelet dysfunction?", "Does the image suggest that hemorrhagic transformation has led to further tissue injury during reperfusion, exacerbating functional loss?", "Can you see areas where capillary compression or microvascular disruption might be impairing local oxygen delivery?", "Is there a region where damaged vessels appear more fragile and susceptible to recurrent rupture or further vascular injury?", "Does the image indicate that hemorrhagic expansion may be blocking collateral vascular routes, reducing the potential for compensatory circulation?", "Can you identify signs of increased intracranial pressure or edema that could be causing more pronounced neurological deficits under stress conditions?", "Is there evidence that blood components within the parenchyma are modulating the local immune response to injury, such as altered immune cell recruitment or activation?"], "functions": ["Does the image show an area of tissue with evidence of both bleeding and localized cell death?", "Can you identify a region where normal tissue structure appears disrupted, possibly indicating functional loss?", "Is there a visible area suggesting vessel obstruction accompanied by secondary bleeding into the surrounding tissue?", "Does the image contain signs of local tissue damage that could be caused by hypoxia or mechanical disruption from extravasated blood?", "Can you see features consistent with altered coagulation, inflammation, or tissue repair processes in a localized region?", "Is there an area where reduced oxygenation or hypoxemia might be inferred from tissue appearance?", "Does the image show a region where cellular metabolism could be impaired due to energy failure or accumulation of metabolic byproducts?", "Can you identify tissue changes that might be associated with leukocyte infiltration or the release of pro-inflammatory mediators?", "Is there evidence of increased vascular permeability, such as fluid or blood component accumulation leading to edema in a focal area?", "Does the image reveal a region where impaired circulation or reduced lymphatic drainage might result in waste accumulation?"]}, "no_questions": {"contexual_properties": ["Is there a noticeable shortening of a limb or bone segment, possibly due to overlapping bone fragments?", "Can you observe changes in skin color, such as bruising or ecchymosis, overlying a region of bone disruption?", "Is there visual evidence of increased bleeding or hemorrhage around a disrupted bone area, such as pooling of blood or vascular injury?"], "properties": ["Are there radiographic features such as displaced, comminuted fragments, wide fracture gaps, and soft tissue shadowing present?", "Does the image reveal significant bone loss, such as a missing segment or loss greater than 2 centimeters?", "Can you see signs of a large hematoma, with a volume possibly between 200 and 1000 milliliters?"], "relational": ["Is there evidence of damage to supporting structures like the periosteum or surrounding muscles near a large bone?", "Can you identify an injury that may affect the musculoskeletal system?", "Does the image suggest possible compromise of the circulatory system near a major bone injury?"], "contexual_behavior": ["Can you identify signs of disrupted blood flow or possible ischemia near a site of significant bone damage?", "Are there visual cues indicating a disturbance in calcium or mineral balance at the site of a severe bone injury?", "Does the image show a bone injury where the segments appear misaligned or separated, suggesting delayed or non-union?"], "functions": ["Is there evidence of overwhelmed tissue repair mechanisms or delayed regeneration at the injury site?", "Is there visual evidence of significant blood loss or features indicating hemodynamic instability?", "Does the image suggest a disruption in mineral metabolism, such as signs of calcium or phosphate imbalance?"]}}, "inflamed exocervix": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system and projects into the vaginal canal?", "Is there an area adjacent to both the vagina and the endocervix visible in the image?", "Can you identify a region composed mainly of non-keratinized stratified squamous epithelium and underlying connective tissue?", "Does the image contain a portion of tissue that is contiguous with the endocervix at the squamocolumnar junction?", "Is there a structure that receives blood supply from branches of the uterine or vaginal arteries?", "Can you see a region whose lymphatic drainage is associated with parametrial, internal iliac, or obturator lymph nodes?", "Does the image include an outer portion of the cervix that is connected to both the uterus and the vagina?", "Is there a visible area that forms part of the cervical portio vaginalis?", "Can you identify a region that is part of the ectocervix and lies adjacent to the cervical canal?"], "contexual_behavior": ["Is there a region that appears to have reduced barrier function against pathogens, possibly indicating increased susceptibility to infection?", "Can you identify an area where secretion of inflammatory mediators or cytokine release might be occurring in response to tissue injury or microbial invasion?", "Does the image show evidence of impaired mucus production or gland dysfunction due to inflammation?", "Is there a structure that seems more susceptible to infection because of compromised epithelial integrity?", "Can you see any indication that the passage of sperm might be hindered due to altered mucus quality or changes in the cervical environment?", "Does the image suggest an altered or impaired healing response, possibly due to chronic inflammation interfering with tissue repair mechanisms?", "Is there visual evidence of increased recruitment of immune cells in response to tissue damage or infection?", "Can you identify an area where normal epithelial regeneration or cellular turnover appears disrupted by persistent inflammation?", "Does the image show signs of impaired tissue repair, such as ongoing tissue damage or chronic inflammatory changes?", "Is there evidence of increased vascular permeability, such as edema or leukocyte infiltration, associated with acute inflammation?", "Can you see any indication that protective function during menstruation might be reduced due to weakened epithelial barriers or immune defenses?", "Does the image suggest an altered response to hormonal changes, possibly due to disrupted hormone receptor signaling or tissue sensitivity?", "Is there a region that appears to have decreased resistance to mechanical stress, potentially due to weakened tissue structure from inflammation?", "Can you identify an area where enhanced cytokine release might be occurring as part of a local immune defense mechanism against infection?", "Does the image show signs of impaired cellular turnover, such as abnormal cell proliferation or differentiation, due to inflammatory processes?"], "functions": ["Does the image show a tissue that appears to be mounting a local immune response?", "Is there evidence of increased vascular permeability, such as swelling or redness, in any mucosal area?", "Can you identify a region where immune cells like neutrophils or macrophages might be recruited to the site of inflammation?", "Does any structure in the image display signs of epithelial disruption or compromised tissue integrity?", "Is there a visible increase in mucus production or changes in mucus appearance that could indicate altered mucin content?", "Can you see features suggesting the release of inflammatory mediators, such as localized redness or edema?", "Is there evidence of cellular infiltration that could reflect cytokine or chemokine activity?", "Does any area appear to be undergoing epithelial regeneration or tissue repair?", "Can you identify a region where antimicrobial activity might be enhanced, such as increased secretion or surface changes?", "Is there a structure that could be modulating its local microenvironment, for example by showing changes in pH-sensitive staining or altered cellular composition?", "Does the image show signs that pro-inflammatory mediators might be present, such as increased immune cell presence or tissue swelling?", "Is there evidence of antigen presentation, such as clusters of immune cells interacting with epithelial surfaces?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there any indication that tissue samples weighing between 0.5 and 5 grams each are being collected?", "Does the image suggest that approximately 20 to 50 photographs are being taken as part of the process?", "Does the setting appear to be maintained at a temperature between 16 and 20 degrees Celsius?"], "relational": ["Can you see evaluation of anatomical connections like vascular pathways or nerve tracts?", "Does the image indicate investigation at multiple anatomical levels, such as both gross and tissue level?", "Is there evidence of sampling different tissue types, for example, parenchymal or muscle tissue?"], "contexual_behavior": ["Are there visual indications of direct examination of affected tissues that could provide insight into disease mechanisms during an emerging epidemic?", "Is there evidence of advanced tissue decomposition that could obscure anatomical or histological features, potentially reducing diagnostic yield?", "Does the scene suggest that data collection for public health surveillance during a pandemic is being performed, such as documentation of mortality patterns or pathogen characteristics?"], "functions": ["Is there any evidence of collecting data that could contribute to public health surveillance, such as identifying mortality trends or emerging diseases?", "Is there evidence of a process that documents disease or provides information for legal or educational purposes?", "Can you identify activities focused on examining internal organs for pathological findings?"]}}, "basilar skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a fracture involving the base of the skull, particularly in bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Is there a fracture line at the cranial base that appears less than a few millimeters wide?", "Does the image reveal a break limited to the thickness of the cranial base bones, typically only a few millimeters deep?", "Can you see a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Is there a lucent line traversing the base of the skull visible on the image?", "Does the image show an air-fluid level or evidence of pneumocephalus near the base of the skull?", "Can you identify any signs of cerebrospinal fluid leakage in association with a skull base fracture?", "Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Does the image suggest a unilateral fracture at the base of the skull, rather than a bilateral one?", "Is the temporal bone involved in the observed skull base fracture?", "Can you estimate whether the displacement of the fracture at the skull base is minimal, less than 2 millimeters?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?", "Are there air-fluid levels present near the base of the skull, as seen in about 20% to 30% of such fractures?", "On CT imaging, is there a hypodense (lucent) line at the base of the skull relative to the surrounding bone?", "Can you observe bruising patterns such as blue or purple discoloration behind the ear or around the eyes, which may change to yellow-green as they resolve?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Can you identify abnormalities in the anterior, middle, or posterior cranial fossae?", "Is there any indication of injury near the course of cranial nerves like the olfactory, optic, or facial nerves?", "Does the image reveal changes involving foramina such as the foramen magnum or cribriform plate?", "Are there visible alterations adjacent to the inner ear, nasal cavity, or orbit?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?", "Is there evidence of communication between the cranial cavity and spaces such as the subarachnoid space or paranasal sinuses?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Are there signs of disruption in sinuses such as the sphenoid or ethmoid sinus?", "Can you identify exposure or compromise of anatomical pathways like cerebrospinal fluid pathways or the auditory canal?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a disruption in the structural integrity of the skull base that could compromise brain protection?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Can you identify features suggesting a breach between the nasal cavity and cranial cavity, such as a defect in the cribriform plate?", "Does the image reveal any signs that could explain cranial nerve deficits, such as those affecting facial movement, hearing, vision, or swallowing?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?", "Can you see any indications that might increase the risk of infection entering the central nervous system, such as a direct pathway for pathogens?", "Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Are there features present that could facilitate the development of a cerebrospinal fluid leak due to openings in the dura mater or bone?", "Is there any sign of functional impairment, such as altered consciousness, seizures, or focal neurological deficits, that could be explained by a structural abnormality at the skull base?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of increased cell proliferation, such as a higher number of mitotic figures compared to normal regions?", "Is there a section where the epithelial layer is thicker than normal, with several cell layers visible?", "Is there evidence of increased stratification, with multiple layers of epithelial cells present in a localized area?"], "relational": ["Does the image display abnormal proliferation involving epithelial, glandular, or stromal cells within a defined anatomical boundary?", "Is there a visible distinction between affected epithelial or glandular cells and the adjacent stroma or basement membrane?", "Can you see regions where glandular outlines or tissue margins define the extent of an abnormal proliferation?"], "contexual_behavior": [], "functions": ["Does the image show alterations in cellular signaling pathways related to growth, differentiation, or apoptosis?", "Can you identify a region where the normal tissue structure appears disrupted or disorganized?", "Does the image reveal loss of normal tissue layering or increased cellular density?"]}}, "alpha smooth muscle actin immunohistochemical": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show cells with moderate to strong staining intensity?", "Can you identify regions where positive cells are present based on staining?", "Is there a staining pattern that primarily highlights smooth muscle cells or myofibroblasts?", "Does the staining appear localized within the cytoplasm of certain cells?", "Can you observe a brown coloration in the tissue, suggesting the use of DAB chromogen?", "Is there evidence of a staining protocol that would require an antibody concentration in the range of 1 to 5 micrograms per milliliter?", "Does the image suggest detection of a protein with an approximate molecular weight of 42 kilodaltons?", "Is there any indication that the staining procedure was performed at a pH between 7.2 and 7.6?", "Can you infer that the incubation time for the staining was between 30 and 60 minutes at room temperature?", "Does the image suggest that the staining was carried out at a temperature of about 20 to 25 degrees Celsius?"], "relational": ["Does the image show staining that highlights structures within blood vessels or the gastrointestinal tract?", "Can you identify regions in the image where smooth muscle cells or myofibroblasts are specifically marked?", "Is there evidence of staining in anatomical features such as vascular walls or the muscularis layer?", "Does the image display highlighted regions corresponding to the cardiovascular, respiratory, or digestive systems?", "Can you see areas where actin filaments in smooth muscle tissue are visually accentuated?", "Are there connective tissue components such as myofibroblastic stroma or fibrous septa that appear distinctly stained?", "Does the image reveal the architecture of vessel walls, including the tunica media or vascular smooth muscle layers?", "Can you identify organ systems in the image that contain cells positive for this type of staining, such as the reproductive or genitourinary systems?", "Are anatomical boundaries like muscularis mucosae or tumor margins visually defined by the staining pattern?", "Does the image show histological structures such as smooth muscle bundles or pericytic layers that are specifically highlighted?"], "contexual_behavior": [], "functions": ["Does the image show regions where contractile force is generated within smooth muscle or myofibroblast-containing tissues?", "Can you identify areas where actin-myosin interactions might be enabling muscle contraction?", "Is there evidence of smooth muscle differentiation or myofibroblast activation in the tissue?", "Does the image highlight regions suggestive of tissue repair or fibrosis due to myofibroblast activity?", "Are there areas indicating wound contraction or extracellular matrix deposition as part of tissue remodeling?", "Can you see specific labeling of contractile filaments in vascular smooth muscle cells within blood vessels?", "Does the staining pattern reveal cells engaged in contractile or reparative processes associated with tissue remodeling?", "Are there features consistent with myofibroblast-mediated wound closure?", "Can you identify regions where regulation of vascular tone, such as vasoconstriction or vasodilation, might be occurring?", "Does the image provide visual evidence for the assessment of fibrosis through the distribution of activated myofibroblasts?"]}, "no_questions": {"contexual_properties": ["Is there swelling around a horizontal ear lobe crease that could be due to local infection, trauma, or an allergic reaction?", "Is there evidence of decreased elasticity in the ear lobe, such as sagging or folding, that could be related to collagen or elastin fiber degradation near a horizontal crease?", "Do you notice any color changes along a horizontal crease on the ear lobe that could indicate inflammation, bruising, or vascular changes?"], "properties": ["Does the ear lobe display a crease with a width of about 1 to 2 millimeters?", "Is there a feature on the ear lobe that measures approximately 1 to 2 centimeters in length?", "Is there a visible indentation on the ear lobe that is more likely to be found bilaterally than unilaterally?"], "relational": ["Does the image display a marking that is part of the integumentary system and located on the external ear?", "Can you identify a feature situated within the inferior part of the ear lobe?", "Can you observe a crease associated with the skin and underlying connective tissue of the ear lobe?"], "contexual_behavior": ["Does the image show a feature that becomes more pronounced in individuals with coronary artery disease?", "Can you identify a feature that often correlates with reduced tissue elasticity as a result of aging?", "Does the image contain a marker that may reflect altered collagen metabolism in someone with diabetes mellitus?"], "functions": ["Can you identify a visible sign that may be used as a clinical marker for certain conditions?", "Does the image contain a physical sign that might be noted during a cardiovascular assessment?", "Is there a crease present that could be associated with increased cardiovascular risk?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Are there indications of decreased gas exchange surface area, such as obliteration of alveolar spaces by fibrous tissue?", "Can you identify regions of increased opacity on imaging that might result from alveolar spaces being filled with granulation tissue and exudates?", "Does the image reveal any signs of lung volume loss, such as contraction of the parenchyma, which could be due to fibrosis and scarring?"], "properties": ["Do you see signs of increased lung tissue density, possibly in the range of 0.4 to 0.6 grams per cubic centimeter?", "Can you identify areas that might contain fibroblasts, myofibroblasts, macrophages, or lymphocytes?", "Is there evidence of increased water content in the lung tissue, suggesting more than 80% by weight?"], "relational": ["Does the image reveal any abnormalities in alveolar or interstitial tissue?", "Is there evidence of altered alveolar walls, bronchioles, or interstitium?", "Can you detect the presence of cells such as fibroblasts, macrophages, or lymphocytes within lung lesions?"], "contexual_behavior": [], "functions": ["Can you observe features suggesting decreased lung compliance or restrictive ventilatory patterns?", "Can you see areas where normal alveolar structure is lost and replaced by fibrotic tissue?", "Does the image suggest ongoing fibroproliferation or collagen deposition consistent with pulmonary fibrosis?"]}}, "brain": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears swollen, which could indicate conditions like cerebral edema or infection?", "Is there evidence of shrinkage or reduced size in a structure that might be associated with aging or neurodegenerative diseases?", "Can you identify an area with decreased volume that could be related to disorders such as Alzheimer's disease or malnutrition?", "Does the image reveal abnormal lesions that might suggest multiple sclerosis, stroke, or a tumor?", "Is there visible accumulation of fluid within a structure, as seen in hydrocephalus or meningitis?", "Can you detect regions with increased iron deposition, which may occur in neurodegenerative diseases like Parkinson's disease?", "Is there a change in color, such as pallor or discoloration, that could result from hypoxia or hemorrhage?", "Does the structure appear softer than normal, possibly due to liquefactive necrosis or severe hypoxic injury?", "Is there evidence of increased firmness, which might be caused by chronic gliosis or calcification?", "Can you see plaques or deposits that are characteristic of Alzheimer's disease or demyelinating disorders?", "Are there increased white matter lesions visible, which could be associated with aging or small vessel disease?", "Does the image suggest atrophy, as seen in chronic neurodegenerative diseases or after prolonged injury?", "Is there any indication of increased intracranial pressure, such as compression or displacement of adjacent structures?", "Can you identify hemorrhages that might be due to hypertension, trauma, or coagulopathies?", "Is there evidence of abnormal electrical activity, which could be related to epilepsy or encephalopathy?", "Can you detect amyloid accumulation, as seen in Alzheimer's disease or cerebral amyloid angiopathy?", "Does the structure display abnormal tissue density, which may be present in stroke, tumors, or demyelinating diseases?", "Is there a region with altered metabolic activity, either increased or decreased, that could suggest epilepsy, tumors, or neurodegenerative diseases?", "Can you see calcifications that might be due to congenital infections, metabolic disorders, or chronic infarcts?", "Is there evidence of changes in neurotransmitter-related features, which could be associated with psychiatric disorders or Parkinson's disease?"], "properties": ["Is there a structure in the image that has an irregular, convoluted surface with visible gyri and sulci?", "Can you identify an object that appears pale grayish-pink in color?", "Does the image show a structure whose size could be approximately 15 centimeters in length and 14 centimeters in width?", "Is there an object present that could have a volume between 1,200 and 1,500 milliliters?", "Can you see a structure that is likely to contain cell types such as neurons, astrocytes, or oligodendrocytes?", "Is there evidence of a region that could contain around 86 billion neurons?", "Does the image include a structure where the number of glial cells might be roughly equal to or slightly greater than the number of neurons?", "Can you identify an object that might have a gray matter to white matter ratio of about 1.3 to 1?", "Is there a structure that could have a water content of approximately 75% to 80% by weight?", "Does the image show an object that might have a lipid content of about 10% to 12% of its wet weight?", "Is there a region that could contain myelin making up about 20% of its dry weight?", "Can you see a structure that might have a cholesterol content of 15 to 20 milligrams per gram of tissue?", "Is there an object that could have an iron concentration ranging from 30 to 60 micrograms per gram, depending on the region?", "Does the image include a structure that typically maintains a temperature between 36.5 and 38 degrees Celsius?", "Can you identify an object that would normally have a pH between 7.1 and 7.4?", "Is there a region that could consume oxygen at a rate of about 3.5 milliliters per 100 grams per minute?", "Does the image show a structure where the glucose concentration might be between 0.7 and 2.5 millimoles per liter?", "Can you see an object that would likely have a protein content of approximately 8% to 10% of its wet weight?", "Is there a structure present that could weigh between 1,300 and 1,400 grams in an adult human?"], "relational": ["Does the image show a structure that is part of the nervous system?", "Can you identify regions such as the cerebrum, cerebellum, or brainstem in the image?", "Is there a structure that connects directly to the spinal cord via the brainstem or medulla oblongata?", "Are protective membranes like the dura mater, arachnoid mater, or pia mater visible surrounding any structure?", "Does the image include blood vessels such as the internal carotid arteries or vertebral arteries supplying a central organ?", "Can you see internal cavities resembling ventricles, such as the lateral, third, or fourth ventricle?", "Is there evidence of cranial nerves, such as the optic nerve or other nerves originating from a central structure?", "Does the image show a structure protected by the bones of the cranium or skull?", "Are there areas distinguishable as gray matter or white matter within a central organ?", "Can you identify neural tissue or glial cells within any structure present?", "Is there a principal organ of the central nervous system coordinating with the spinal cord visible in the image?"], "contexual_behavior": ["Does the image show a structure that reduces its processing speed during normal aging or neurodegenerative conditions?", "Can you identify an area that would increase neural activity in response to stress via the hypothalamic-pituitary-adrenal axis?", "Is there a structure whose memory formation could be impaired by sleep deprivation affecting REM and slow-wave sleep?", "Does the image contain a region where neurotransmitter release, such as serotonin, norepinephrine, or dopamine, might be decreased in depression?", "Can you see an area that enhances synaptic plasticity during learning through mechanisms like long-term potentiation?", "Is there a structure that fails to regulate motor control in Parkinson\u2019s disease due to degeneration of dopaminergic neurons?", "Does the image show a region that would increase glucose uptake during intense mental activity?", "Can you identify a structure that reduces oxygen consumption during anesthesia as neural activity decreases?", "Is there an area that alters its function during hypoxia by shifting to anaerobic metabolism and reducing neuronal activity?", "Does the image contain a region that shows decreased responsiveness under sedation due to suppression of cortical and subcortical activity?", "Can you see a structure that increases pain perception in chronic pain conditions through central sensitization?", "Is there an area that fails to coordinate sensory input after injury when neural pathways are disrupted by trauma or stroke?", "Does the image show a region that enhances neuroprotection during mild hypothermia by reducing metabolic demand?", "Can you identify a structure that reduces executive function during aging as prefrontal cortex efficiency declines?", "Is there an area that increases neuroinflammation in neurodegenerative diseases due to activation of microglia and astrocytes?", "Does the image contain a region that alters its activity during meditation by modulating the default mode network and increasing alpha wave activity?", "Can you see a structure that shows impaired signal transmission in multiple sclerosis due to demyelination of central nervous system axons?", "Is there a region that increases blood flow during physical exercise to supply active neurons with oxygen and nutrients?", "Does the image show a structure that reduces its ability to regulate emotions in anxiety disorders due to dysregulation of limbic and prefrontal circuits?", "Can you identify an area that fails to maintain homeostasis during severe trauma when autoregulatory mechanisms are overwhelmed?"], "functions": ["Does the image contain a structure responsible for cognition and perception?", "Is there an object that controls movement by sending signals to muscles?", "Can you identify a region involved in processing sensory information?", "Does the image show structures such as the amygdala or limbic system that regulate emotions?", "Is there a visible area associated with memory formation, such as the hippocampus?", "Can you see regions like the basal ganglia or cerebellum that coordinate voluntary actions?", "Does the image include a structure that regulates hormone release through the pituitary gland?", "Is there an area related to language comprehension or production, such as Broca\u2019s or Wernicke\u2019s area?", "Can you identify a region that maintains homeostasis by adjusting bodily functions?", "Does the image show centers like the medulla oblongata or brainstem involved in regulating breathing and heart rate?", "Is there a structure supporting learning and cognition through neural plasticity?", "Can you see association areas that integrate information from multiple senses?", "Is there a region involved in regulating sleep and circadian rhythms?", "Does the image contain a structure that participates in the stress response by activating the HPA axis?", "Can you identify an area involved in decision making, such as the prefrontal cortex?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a region that would display apple-green birefringence under polarized light microscopy?", "Is there evidence of fibrillar material with an average diameter of approximately 7\u201310 nanometers?", "Does the image show extracellular material likely composed of protein fibrils, glycosaminoglycans, or serum amyloid P component?"], "relational": ["Can you observe features that might be related to restrictive cardiomyopathy, arrhythmias, or heart failure?", "Is there evidence of structural changes such as tissue stiffening or organ enlargement in any organ that could indicate impaired function?", "Are there signs of plasma cell or macrophage presence associated with abnormal extracellular deposits?"], "contexual_behavior": [], "functions": ["Are there blood vessels that appear fragile or show signs of impaired perfusion, such as hemorrhage or ischemic changes?", "Can you identify areas with extracellular material accumulation that might lead to tissue stiffness or loss of normal function?", "Is there a structure where healthy tissue appears to be replaced by abnormal deposits, potentially impairing physiological processes?"]}}}
[ { "answer": "fractures brain which and close-up view of these fractures", "extracted_concepts": [ "slide", "brain", "fractures" ], "question": "what is slide?" }, { "answer": "fractures", "extracted_concepts": [ "slide", "brain", "fractures" ], "question": "what is fractures brain which is slide and close-up view of these fractures?" }, { "answer": "yes", "extracted_concepts": [ "close-up view", "slide", "fractures brain" ], "question": "is fractures brain which is slide and close-up view of these fractures slide?" }, { "answer": "no", "extracted_concepts": [ "ear lobe crease", "lateral view of head", "web neck" ], "question": "is lateral view of head with ear lobe crease and web neck other photos in file slide?" }, { "answer": "fractures brain which is slide and close-up view of these fractures is slide", "extracted_concepts": [ "slide", "brain", "fractures" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "slide", "brain", "fractures" ], "question": "does this image show fractures brain which is slide and close-up view of these fractures is slide?" }, { "answer": "no", "extracted_concepts": [ "close-up view", "fractures", "nipple duplication", "brain", "slide" ], "question": "does nipple duplication show fractures brain which is slide and close-up view of these fractures is slide?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "intraductal papillomatosis", "apocrine metaplasia" ], "question": "is intraductal papillomatosis with apocrine metaplasia present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basilar skull fracture" ], "question": "is basilar skull fracture present?" }, { "answer": "no", "extracted_concepts": [ "acid" ], "question": "is acid present?" }, { "answer": "fractures brain which and close-up view of these fractures", "extracted_concepts": [ "close-up view", "slide?", "brain", "fractures" ], "question": "what is slide?" }, { "answer": "fractures", "extracted_concepts": [ "fractures", "close-up view", "slide", "fractures brain" ], "question": "what is fractures brain which is slide and close-up view of these fractures?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" } ]	["close-up view", "intraductal papillomatosis", "apocrine metaplasia", "fractures", "acid", "bone", "web neck", "nipple duplication", "calvarium", "basilar skull fracture", "lateral view of head", "fractures brain", "ear lobe crease", "slide?", "brain", "slide"]	{"close-up view": {"yes_questions": {"contexual_properties": ["Does the image reveal changes in texture that might suggest inflammation, fibrosis, or abnormal cell growth?", "Is there evidence of discoloration that could indicate bruising, jaundice, cyanosis, or localized bleeding?", "Can you observe swelling that might be due to fluid accumulation, infection, or recent trauma?", "Are there abnormal surface features such as ulceration, nodules, or irregular growths visible?", "Does the image show increased redness that could be associated with inflammation, infection, or an allergic reaction?", "Are there lesions or spots present that resemble petechiae, macules, or papules?", "Can you detect changes in moisture level, such as excessive sweating, dryness, or the presence of exudate?", "Is there visible scaling or flaking that could be related to conditions like psoriasis, eczema, or a fungal infection?", "Do you see changes in the size of any structures that might suggest hypertrophy, atrophy, or tumor formation?", "Is there abnormal pigmentation present, such as areas of depigmentation, dark patches, or post-inflammatory color changes?", "Are there areas of tissue breakdown or ulceration that could be due to infection, pressure, or poor blood supply?", "Can you observe thickened tissue that might indicate lichenification, callus formation, or chronic inflammation?", "Is there loss of normal structure suggestive of necrosis, erosion, or tissue destruction?", "Does the image show increased vascularity that could be due to new blood vessel formation, inflammation, or vascular malformations?", "Are there signs of fluid accumulation or edema that might result from increased vascular permeability, lymphatic blockage, or heart failure?"], "properties": ["Does the image display a region with high magnification, such as between 5x and 40x?", "Is there an area where small structures are shown in fine detail due to high resolution?", "Can you identify a portion of the image that covers only a limited area of the subject?", "Is there a region where only a thin plane is in sharp focus, indicating a shallow depth of field?", "Does the image contain features that appear on a millimeter or micrometer scale?", "Is there a section where the colors appear highly accurate and true to the subject?", "Can you see an area with increased contrast that helps distinguish fine details and boundaries?", "Is there a region of the image that appears especially sharp and free from distortion?", "Does any part of the image exhibit a high pixel density, resulting in crisp and detailed visualization?", "Is there evidence of bright lighting or enhanced illumination on a small area of the subject?"], "relational": ["Does the image provide a perspective where individual cells or capillaries are visible?", "Can you observe anatomical features such as cell layers or microvasculature in the depicted tissue?", "Is there evidence of glandular units or extracellular matrix in the detailed area shown?", "Does the image reveal cellular components like nuclei, mitochondria, or cell membranes?", "Can you see microscopic details while still recognizing the broader anatomical context?", "Are microstructures such as basement membrane, tight junctions, or microvilli apparent in the view?", "Does the image allow you to distinguish between tissue, cellular, and subcellular levels of organization?", "Can you identify connections between cells, such as cell junctions, intercellular bridges, or synapses?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image suggest the absence of estrogen receptor, progesterone receptor, or HER2 expression in a tumor?", "Are there visible signs of lymphatic involvement, such as enlarged axillary, internal mammary, or supraclavicular lymph nodes?", "Does the image show a lesion or abnormality within the breast, axilla, or chest wall regions?"], "contexual_behavior": [], "functions": ["Does the image reveal features suggestive of enhanced epithelial-mesenchymal transition or increased matrix metalloproteinase activity, which could promote tumor invasion?", "Can you identify a tumor that appears to evade immune detection, possibly by reducing antigen presentation or increasing immune checkpoint molecules?", "Is there visual evidence of interaction between tumor cells and stromal or immune cells, such as fibroblast activation or changes in immune cell infiltration?"]}}, "intraductal papillomatosis": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to have increased in size, possibly suggesting hormonal influence or disease progression?", "Can you identify areas where there are multiple similar lesions, indicating widespread proliferation of ductal epithelial cells?", "Does the image show any regions with abnormal cellular features that could suggest atypia or malignant transformation?", "Is there evidence of necrotic areas within a lesion, possibly due to ischemia or malignant progression?", "Can you see any calcified regions within a lesion that might result from chronic inflammation or degeneration?", "Are there visible changes in texture, such as fibrosis, cystic degeneration, or necrosis, within any of the lesions?", "Does the image show increased vascularity in a lesion, which could be due to active proliferation or inflammation?", "Is there a cystic appearance to any lesion, possibly resulting from ductal obstruction or fluid accumulation?", "Can you identify areas with atypical cell morphology, suggesting cellular atypia or progression toward malignancy?", "Are there regions with increased mitotic activity, indicating rapid epithelial proliferation or neoplastic change?", "Does the image reveal hemorrhagic areas within a lesion, possibly due to vessel rupture or trauma?", "Are there noticeable color changes within a lesion, such as those caused by hemorrhage, necrosis, or cystic degeneration?", "Can you see evidence of ductal dilation that might result from papillary growth obstructing normal ductal flow?", "Is there a region with pronounced epithelial proliferation, potentially related to hormonal stimulation or neoplastic progression?", "Does the image show architectural distortion of ductal structures, possibly due to extensive papillary growth or stromal reaction?"], "properties": ["Does the image show multiple lesions within a duct system, with more than five present?", "Can you identify structures that have a papillary or frond-like appearance?", "Are there lesions that appear tan, pink, or whitish in color?", "Is there evidence of both epithelial and myoepithelial cells within the lesions?", "Do the lesions display a low mitotic rate or low proliferation index, as might be indicated by Ki-67 staining?", "Can you observe moderately increased epithelial thickness compared to adjacent normal ducts?", "Are the nuclei within the lesions mostly uniform, with minimal or absent atypia?", "Is the stroma within the lesions scant or moderate in amount?", "Are the lesions generally small in volume, often less than 1 cubic centimeter?", "Do you see a complex papillary architecture with multiple fibrovascular cores?", "Is the consistency of the tissue soft to rubbery in appearance?", "Is necrosis absent within the lesions?", "Do the cells within the lesions show positive staining for estrogen or progesterone receptors?", "Is there only mild fibrosis present in the affected tissue?", "Do the cells have eosinophilic and granular cytoplasm?", "Are there any focal or infrequent calcifications visible within the lesions?", "Does the tissue density of the lesions resemble that of normal breast parenchyma?"], "relational": ["Does the image show any abnormal proliferation of epithelial cells within the mammary ducts?", "Is there evidence of changes involving the lactiferous ducts or terminal duct-lobular units?", "Can you identify any alterations in the breast parenchyma or mammary duct system?", "Does the image reveal any lesions or abnormalities in the central, subareolar, or peripheral areas of the breast?", "Are there visible changes in the fibrous stroma, adipose tissue, or connective tissue surrounding the ductal system?", "Can you see any structures within the breast that appear to involve both epithelial and myoepithelial cells?", "Is there any indication of involvement of the nipple region or areolar tissue?", "Does the image show any abnormalities adjacent to lobules or blood vessels within the mammary gland?", "Are there features suggestive of pathology contained within the thoracic wall or mammary gland system?"], "contexual_behavior": ["Does the image show a ductal lesion with increased cellular proliferation that could be associated with elevated estrogen or progesterone levels?", "Is there evidence of impaired epithelial differentiation within a ductal structure that might suggest chronic inflammation?", "Can you identify a ductal abnormality exhibiting increased secretion, possibly due to obstruction or infection?", "Does the image contain a lesion with reduced apoptotic activity, which could be linked to oncogenic mutations affecting cell death pathways?", "Is there a ductal proliferation with altered growth rate that might be influenced by pregnancy or lactation?", "Can you see features suggesting an increased risk of malignant transformation, potentially associated with genetic predisposition such as BRCA mutations?", "Does the image reveal loss of normal ductal architecture or tissue remodeling that could result from persistent infection?", "Is there evidence of increased local inflammation, such as immune cell infiltration or cytokine-mediated changes, in response to tissue injury within a ductal structure?", "Can you identify a ductal lesion with decreased proliferative activity that might be related to menopause and reduced sex hormone levels?", "Does the image show signs of altered cellular signaling in a ductal lesion, possibly due to the influence of endocrine disruptors on hormone receptor pathways?"], "functions": ["Does the image show evidence of multiple papillary lesions within breast ducts?", "Can you identify areas where the ductal epithelium appears to have abnormal proliferation or stratification?", "Is there visual indication of ductal lumens being obstructed or narrowed, potentially affecting secretion or flow?", "Does the image reveal signs of localized tissue remodeling, such as epithelial hyperplasia or changes in the surrounding stroma?", "Can you observe structural or functional abnormalities in the lining of breast ducts?", "Is there evidence of increased cellular proliferation within ductal tissue, possibly leading to the formation of multiple papillomas?", "Do you see papillary projections or architectural alterations within the ductal lumen?", "Are there signs of immune cell infiltration, such as the presence of lymphocytes or macrophages, in or around the ducts?", "Can you detect disruption of normal epithelial turnover, such as the accumulation of atypical cells within the ducts?", "Is there any indication of features associated with an increased risk of malignant transformation, such as areas resembling ductal carcinoma in situ?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image contain a wall that looks highly elastic or capable of significant distension?", "Is there a structure whose wall appears soft and rugose due to the presence of folds?", "Is there evidence of a moist environment maintained by mucosal secretions?"], "relational": ["Can you see a structure composed of stratified squamous epithelium, smooth muscle, and connective tissue?", "Does the image include an external opening that serves as the entrance to an internal canal, corresponding to the vulva or vaginal orifice?", "Is there a structure located within the pelvic region of the body?"], "contexual_behavior": ["Can you see signs of weakened barrier function that might result from disruption of the normal microbial flora, such as after antibiotic use?", "Can you identify features suggesting slowed epithelial repair or regeneration, which could be related to aging?", "Is there evidence of enhanced protective flora, possibly favoring Lactobacillus dominance, as might occur during pregnancy?"], "functions": ["Is there a feature that serves as both an entry and exit point for reproductive processes in the female reproductive tract?", "Can you identify a passageway that enables the exit of menstrual blood from the uterus?", "Does the image contain a moist, muscular canal that could guide sperm toward the cervix?"]}}, "apocrine metaplasia": {"yes_questions": {"contexual_properties": ["Does the image show epithelial changes in breast tissue that are more common with aging or fibrocystic alterations?", "Can you identify areas where epithelial cells appear enlarged, suggesting a transformation to a different cell phenotype?", "Is there evidence of cytoplasmic granularity, indicating the accumulation of secretory granules within cells?", "Do any cells display increased pink staining of the cytoplasm, consistent with protein accumulation on H&E sections?", "Are there nuclei that appear larger and rounder than usual, suggesting increased cellular activity?", "Can you observe cytoplasmic vacuoles within epithelial cells, indicating secretory changes?", "Is there a region where the epithelial lining of a duct or cyst appears multilayered or stratified?", "Do you see a change in cell shape from cuboidal or columnar to larger, polygonal forms?", "Are mitotic figures infrequent in the area of interest, supporting a benign and non-proliferative process?", "Can you detect an increase in cytoplasmic volume within the epithelial cells?", "Is there a noticeable alteration in staining characteristics, such as enhanced eosinophilia and granularity, in the cytoplasm?", "Are the observed changes more prominent in association with breast cysts or in tissue from perimenopausal or postmenopausal individuals?", "Do the epithelial cells exhibit features of altered secretory activity, such as apocrine-type secretion?", "Is there evidence of increased cell layering in regions showing ductal epithelial hyperplasia?"], "properties": ["Does the image show cells with abundant, pink to reddish cytoplasm under light microscopy?", "Can you identify clusters or sheets of cells lining cystic spaces?", "Are there cells that appear larger than typical ductal epithelial cells?", "Is there evidence of cells with round or polygonal shapes and mononuclear features?", "Do the cells display prominent cytoplasmic granularity, possibly due to secretory granules?", "Are the nuclei of these cells enlarged and round to oval in appearance?", "Can you observe a low nuclear-to-cytoplasmic ratio in any cell population present?", "Is the chromatin in the nuclei finely granular and evenly distributed?", "Are there frequent apical snouts visible on the luminal surface of any cell clusters?", "Do the cells exhibit strong eosinophilic staining with hematoxylin and eosin?", "Is there moderate to high cytoplasmic lipid content visible in any of the cells?", "Can you see evidence of low mitotic activity, such as rare or absent mitotic figures?", "Are there cells that would likely be positive for GCDFP-15 or androgen receptor based on their morphology?"], "relational": ["Does the image show a benign alteration of glandular epithelial cells within the mammary gland?", "Can you identify areas within breast tissue where epithelial cells resemble apocrine cells?", "Is there evidence of cells with abundant eosinophilic cytoplasm and prominent nuclei in the mammary gland region?", "Does the image contain structures adjacent to normal mammary ducts or lobules?", "Can you see features associated with terminal duct lobular units in the breast?", "Is there a region within the female reproductive system, specifically the mammary gland, displaying metaplastic epithelial changes?", "Are there cysts or fibrocystic changes present near areas of altered epithelial cells in the breast tissue?", "Does the image show supporting tissues such as fibrous stroma or adipose tissue surrounding regions of glandular change?"], "contexual_behavior": ["Is there evidence of increased secretory activity in breast tissue that could be associated with periods of hormonal stimulation such as the luteal phase?", "Can you identify regions in breast tissue where cellular turnover appears impaired, possibly due to chronic inflammation or persistent inflammatory mediators?", "Does the image show any alterations in tissue function that might correspond to fluctuations in estrogen or progesterone levels?", "Is there a visible decrease in epithelial barrier integrity in areas exposed to sustained tissue injury or inflammation?", "Can you detect enhanced local immune signaling, such as increased cytokine or chemokine activity, in the presence of infection within the tissue?", "Are there regions in breast tissue where secretory function appears reduced, potentially reflecting the effects of menopause or estrogen deficiency?", "Does the image reveal altered protein expression patterns that could be linked to oxidative stress or increased reactive oxygen species?", "Is there evidence of tissue failing to respond to growth factor stimulation, possibly due to defects in receptor signaling or downstream pathways?", "Can you observe increased metabolic activity in association with proliferative breast disease, suggesting elevated cellular proliferation and energy demand?", "Are there areas displaying decreased functional differentiation, which might be indicative of neoplastic conditions and loss of normal regulatory mechanisms?"], "functions": ["Does the image show epithelial cells within glandular tissue that appear transformed toward an apocrine-like phenotype?", "Can you identify areas where the secretion process seems to involve the release of cytoplasmic material along with secretory products?", "Is there evidence of increased cytoplasmic granularity or prominent nucleoli in epithelial cells, suggesting enhanced secretory activity?", "Do you observe apocrine-like cells present within ducts or lobules of breast tissue, indicating a histological change?", "Is there a region where local tissue architecture and homeostasis appear preserved despite cellular changes, consistent with a benign process?", "Can you see features suggesting altered responsiveness to hormonal signals, such as changes in receptor expression within glandular epithelium?", "Is there visual evidence of a shift in epithelial cell phenotype that could affect the composition of glandular secretions?", "Do the epithelial cells in the image appear to maintain regenerative capacity, suggesting a reversible and non-neoplastic process?", "Is the integrity of the epithelial barrier preserved, with no signs of compromised protective function despite cellular alterations?", "Does the image lack features associated with neoplasia or malignant transformation in breast tissue, supporting a benign nature of the observed changes?"]}, "no_questions": {"contexual_properties": ["Is there a region that appears reduced in size, possibly indicating atrophic liver conditions or advanced cirrhosis?", "Is there evidence of increased connective tissue in a region affected by chronic liver fibrosis or cirrhosis?", "Can you identify an atrophic appearance in a structure, as seen in end-stage liver disease or chronic atrophy?"], "properties": ["Does the image contain a membrane composed of dense irregular connective tissue with visible collagen and elastic fibers?", "Is there a membrane whose density appears similar to other dense connective tissues, around 1.04 to 1.06 g/cm\u00b3?", "Can you identify a layer with moderate water content, typical of connective tissue?"], "relational": ["Is there a connective tissue sheath surrounding a portal triad within the liver?", "Does the image contain a structure that is part of the liver?", "Does the image contain a structure composed of connective tissue, blood vessels, bile ducts, and lymphatics?"], "contexual_behavior": ["Is there evidence of disrupted microvascular flow within the portal tracts that could impair nutrient exchange in advanced liver pathology?", "Can you observe fibrous thickening within the portal tracts that might increase resistance to portal blood flow, as occurs in portal hypertension?", "Are there features consistent with extensive scarring replacing normal connective tissue in the portal regions, as seen in cirrhosis?"], "functions": ["Is there evidence of a layer that accommodates the expansion and contraction of the liver during physiological changes such as respiration or blood flow?", "Can you identify a structure that provides structural support and protection to hepatic tissue?", "Is there a visible layer that encapsulates the liver and allows blood vessels, lymphatics, and nerves to enter the organ?"]}}, "fractures": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a disruption in the integrity of a structure that could be part of the musculoskeletal system?", "Can you identify any abnormality affecting long bones such as the femur, radius, or tibia?", "Is there evidence of a condition that might compromise mobility or structural support in the appendicular or axial skeleton?", "Does the image display changes in areas near joints like the knee, elbow, hip, or wrist?", "Can you see any involvement of anatomical landmarks such as the epiphysis, diaphysis, metaphysis, or articular surface?", "Is there a visible alteration in regions surrounded by muscle tissue, connective tissue, blood vessels, or skin?", "Does the image suggest an impact on organ systems like the circulatory or nervous system adjacent to a skeletal abnormality?", "Are there signs of stabilization by structures such as ligaments, muscles, periosteum, or external fixation devices?", "Can you detect abnormalities in bones that are weight-bearing or appear osteoporotic?", "Is there visual evidence of disruption near anatomical structures like blood vessels or nerves adjacent to a skeletal region?"], "contexual_behavior": [], "functions": ["Does the image show an area where bone continuity is lost, potentially compromising structural support?", "Can you identify a region where skeletal stability appears disrupted, possibly affecting weight bearing or mobility?", "Is there visual evidence of biological processes such as inflammation or callus formation at a site of bone injury?", "Does the image reveal signs of hematoma formation or accumulation of inflammatory cells near a bone defect?", "Can you see features suggesting debris clearance or recruitment of repair cells at a site of tissue regeneration?", "Is there an area where local blood vessels may be disrupted, leading to reduced perfusion or impaired healing?", "Does the image show a structure that could represent a stabilizing callus or scaffold for new bone growth?", "Can you identify regions where immature bone is being replaced by more organized lamellar bone, indicating structural restoration?", "Is there visual evidence of cellular activity, such as bone matrix synthesis or resorption, contributing to restoration of bone integrity?", "Does the image suggest impaired function of nearby muscles or joints, such as restricted movement or joint stiffness?", "Can you see signs of new bone matrix being formed or damaged bone being resorbed, indicating coordinated bone turnover?", "Is there evidence of progressive mineralization or tissue remodeling that would restore mechanical strength to the bone?", "Does the image suggest the influence of regulatory mechanisms, such as growth factors or cytokines, in the healing process?", "Can you identify features consistent with immobilization, such as maintained bone alignment or restricted movement at the injury site?", "Is there visual indication of nutrient or oxygen delivery supporting tissue repair in the area of bone injury?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image display tissue with diffuse swelling of villi and no visible blood vessels?", "Is there a lesion whose genetic origin could be explained by fertilization of an empty ovum by one or two sperm, resulting in a diploid, androgenetic karyotype?", "Is there an object that could weigh between 50 and 200 grams based on its size and appearance?"], "relational": ["Does the image lack fetal structures such as the embryo, amnion, or umbilical cord within the uterine cavity?", "Can you identify hydropic swelling and abnormal proliferation of chorionic villi in the tissue present?", "Does the image display proliferating cytotrophoblasts or syncytiotrophoblasts within a uterine mass?"], "contexual_behavior": [], "functions": ["Does the image suggest impaired nutrient exchange due to avascular villi or placental dysfunction?", "Does the image contain signs that could be associated with excessive secretion of hormones such as human chorionic gonadotropin?", "Are there indications of systemic maternal effects, such as changes that might be linked to complications like preeclampsia or endocrine disturbances?"]}}, "acid": {"yes_questions": {"contexual_properties": ["Does the image show a solution whose concentration could increase if more solute is added or if some solvent is removed?", "Is there evidence of a substance that would become more diluted if additional solvent, such as water, were mixed in?", "Can you identify a scenario where the pH might change due to variation in hydrogen ion concentration?", "Does the image depict a situation where the composition of a chemical could be altered by the introduction of new species or by a chemical reaction?", "Is there a visible color change that could result from a chemical reaction, the addition of an indicator, or exposure to light?", "Can you see a substance that would become more corrosive if its concentration increased or if it were mixed with other reactive chemicals?", "Is there a context where a substance could become less corrosive through dilution or neutralization?", "Does the image show a container where the volume of a liquid could increase by adding more solute or solvent?", "Is there evidence that the volume of a solution might decrease due to evaporation or removal of material?", "Can you identify a scenario where the density of a liquid might change due to alterations in concentration or temperature?", "Is there a depiction of tissue where accumulation of a certain substance could occur during metabolic disorders such as lactic acidosis or ischemia?", "Does the image suggest elevated levels of a compound in blood during conditions like diabetic ketoacidosis or renal dysfunction?", "Is there a situation where the level of a substance in urine might decrease during metabolic alkalosis or impaired renal excretion?", "Can you see any indication of abnormal levels of a chemical during diseases such as acidosis, poisoning, or renal disease?", "Is there a depiction of the stomach where the content of a particular substance increases after food intake or stimulation by a hormone?", "Does the image show a scenario where the content of a compound in the stomach decreases during fasting or after administration of a neutralizing agent?", "Is there evidence of a substance appearing in an abnormal location, such as during reflux or tissue injury?", "Can you identify a situation where a chemical might become more volatile when heated or if it is a low-boiling-point compound?"], "properties": ["Does the image show a substance that could have a chemical formula like HCl, H2SO4, or CH3COOH?", "Is there an object present whose molecular weight might be around 36.46 g/mol or 98.08 g/mol?", "Can you identify a solution that would likely have a pH less than 7?", "Is there a colorless liquid or substance visible that could be pure or nearly pure?", "Does the image contain a material with a density similar to 1.19 g/cm\u00b3 or 1.84 g/cm\u00b3?", "Can you see a substance that might boil at around 110\u00b0C or 337\u00b0C?", "Is there an object that could melt at temperatures like \u2212114\u00b0C or 10\u00b0C?", "Does the image show a substance that appears highly soluble in water?", "Is there a container or solution that could plausibly have a concentration near 1 mol/L?", "Can you identify a material that might emit a pungent or vinegar-like odor?", "Is there a liquid present that could have a viscosity similar to 1.84 mPa\u00b7s?", "Does the image contain a solution that could have a very low pKa, such as \u22126.3, or a moderate pKa like 4.76?", "Is there a transparent liquid that could have a refractive index around 1.430?", "Can you see a substance that might have a specific heat capacity near 1.38 J/g\u00b7K?", "Is there a solution or liquid that would likely conduct electricity well due to ionization?", "Does the image show something that could have a sour taste if tasted?", "Is there a solution that might have a measurable osmolarity in osmoles per liter?", "Can you identify a material that appears highly corrosive, especially if it is a strong chemical?", "Is there a substance present that could be a liquid, solid, or gas at room temperature depending on its identity?", "Does the image show a material that could have a standard enthalpy of formation similar to \u2212167.2 kJ/mol?"], "relational": ["Does the image show an organ system involved in the production or presence of substances that facilitate digestion?", "Can you identify tissues that interact with corrosive substances, such as the gastric mucosa or esophageal epithelium?", "Is there a visible organ known for secreting substances that lower pH, such as the stomach or kidneys?", "Does the image include anatomical structures exposed to acidic environments during digestion, like the stomach lining or duodenum?", "Can you see cells specialized in producing substances that contribute to a low pH environment, such as parietal cells?", "Is there evidence of body fluids that typically contain substances with acidic properties, such as gastric juice or urine?", "Does the image contain structures that play a role in pathogen defense or nutrient absorption through the action of low pH?", "Can you identify organs or tissues involved in regulating the concentration of hydrogen ions, such as the kidneys or lungs?", "Is there a structure present that contributes to the neutralization or buffering of low pH substances, like the pancreas or liver?", "Does the image show anatomical compartments where acid-base balance is maintained, such as blood plasma or interstitial fluid?"], "contexual_behavior": [], "functions": ["Is there evidence of a substance in the image that contributes to the breakdown of food during digestion?", "Can you identify a feature that might be responsible for activating digestive enzymes?", "Does the image show a process or structure that could be involved in denaturing proteins?", "Is there an indication of a component that helps maintain pH balance within the depicted system?", "Can you see something that might facilitate biochemical reactions or act as an intermediate in metabolism?", "Is there a visible structure that could be responsible for killing pathogens or creating a hostile environment for microbes?", "Does the image suggest the presence of a factor that enhances the absorption of minerals or vitamins?", "Can you identify a process that might participate in the citric acid cycle or facilitate ATP production?", "Is there evidence of a mechanism that supports neurotransmitter synthesis or modulates synaptic activity?", "Does the image include a feature that could help regulate electrolyte balance or influence renal function?", "Can you see something that might participate in buffering systems to maintain pH stability?", "Is there a structure or process that could hydrolyze macromolecules to aid nutrient breakdown?", "Does the image suggest the presence of a factor that provides optimal conditions for enzyme activity?", "Can you identify a component that might disrupt hydrogen bonds to alter protein structure?", "Is there evidence of a process that could support electron transport or drive metabolic pathways?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display any relationship between the coronary arteries and larger cardiovascular structures like the aorta, left ventricle, or right atrium?", "Is there evidence of involvement of the cardiac conduction system or subendocardial regions?", "Is there a visible indication of accelerated atherosclerosis in the coronary circulation?"], "contexual_behavior": [], "functions": ["Is there evidence of myocardial infarction, such as localized tissue damage or scarring in the heart?", "Is there any indication of decreased oxygen delivery to cardiac tissue, such as areas of hypoperfusion or hypoxia?", "Can you detect abnormalities in the cardiac conduction system or features that might suggest arrhythmias?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Can you observe abnormal tissue composition, such as infiltration by inflammatory or fibrous cells, in the setting of advanced liver disease?", "Can you observe calcifications that might indicate chronic granulomatous disease or healed infections?", "Can you detect a change in texture, such as increased firmness or irregularity, due to fibrosis, edema, or chronic inflammation?"], "properties": ["Can you see a layer that might contain fibroblasts, endothelial cells, or occasional immune cells?", "Does the image show a thin, continuous, and smooth membrane enveloping another structure?", "Can you identify a pale or whitish layer that appears to be about 0.5 to 1 millimeter thick?"], "relational": ["Is there a connective tissue sheath surrounding a portal triad within the liver?", "Can you identify a component that is connected to the portal vein, hepatic artery, or bile ducts?", "Does the image show a structure that is part of the hepatic system?"], "contexual_behavior": ["Can you identify signs of impaired bile transport within the portal areas, such as obstruction or inflammation affecting intrahepatic bile ducts?", "Does the image show compression of portal vessels that could indicate reduced support for hepatic blood flow due to fibrotic expansion?", "Are there signs of decreased elasticity in the connective tissue of the portal regions, such as increased stiffness from collagen accumulation in chronic liver disease?"], "functions": ["Does the image show a connective tissue sheath surrounding an organ involved in digestion?", "Can you identify a structure that provides structural support and protection to hepatic tissue?", "Is there a visible layer that encapsulates the liver and allows blood vessels, lymphatics, and nerves to enter the organ?"]}}, "web neck": {"yes_questions": {"contexual_properties": ["Does the image show a neck region with increased width that could be associated with congenital anomalies or lymphatic malformations?", "Is there evidence of a neck structure that appears more pronounced, possibly indicating a genetic disorder such as Turner syndrome?", "Can you observe swelling or edema in the neck area that might suggest acute lymphedema or inflammation?", "Is there visible discoloration in the neck region that could be due to bruising, vascular changes, or underlying skin conditions?", "Does the neck display increased skin folds that might be related to connective tissue disorders or obesity?", "Can you see changes in skin texture on the neck that could result from chronic lymphedema or repeated skin infections?", "Is there a reduction in the thickness or prominence of the neck region that might indicate surgical correction or edema reduction?", "Does the neck area appear less prominent, possibly due to surgical intervention or age-related skin tightening?", "Can you identify changes in skin elasticity in the neck that might be associated with aging or connective tissue diseases?", "Is there evidence of abnormal tissue composition, such as fibrosis or adipose tissue accumulation, in the neck region?", "Does the neck appear edematous, suggesting lymphatic obstruction or ongoing inflammatory processes?", "Are there signs of fibrotic changes in the neck that could be due to chronic inflammation or previous surgical procedures?", "Can you observe a change in the length of the neck region that might be related to growth or surgical reconstruction?", "Is there visible pigmentation change on the neck that could be caused by chronic irritation, sun exposure, or dermatological conditions?", "Does the neck appear thickened, possibly as a response to chronic lymphedema or fibrotic remodeling?"], "properties": ["Does the image show a neck region that appears wider than average, possibly by several centimeters?", "Can you identify lateral skin folds extending from the area behind the ear to the tip of the shoulder?", "Is there a structure where the skin thickness resembles that of typical cervical skin, around 1.5 to 2.5 millimeters?", "Does the neck display broad, laterally extended, and posteriorly sloping skin folds?", "Is the skin color in the lateral neck region similar to adjacent areas, appearing flesh-colored or slightly darker?", "Can you observe skin in the neck area that appears smooth but may also look redundant or slightly wrinkled?", "Is there evidence of excess or overlapping skin folds along the side of the neck?", "Does the region between the mastoid process and the acromion show a continuous web-like extension?", "Can you see signs of reduced skin elasticity in the lateral neck, possibly due to underlying connective tissue changes?", "Is there an indication of increased or abnormally distributed collagen in the skin of the neck folds?", "Does the subcutaneous tissue in the lateral neck appear mildly increased in fat content?", "Is the water content of the skin in the neck region consistent with normal physiological levels?", "Can you estimate if the distance from the mastoid process to the acromion exceeds 10 centimeters?", "Does the skin in the lateral neck area appear to have normal vascularity, with no obvious increase or decrease in blood supply?", "Are tissues such as skin, subcutaneous fat, connective tissue, or fibrous bands visible within the lateral neck folds?"], "relational": ["Does the image show prominent lateral skin folds in the neck region?", "Is there evidence of pterygium colli present in the lateral or posterior neck?", "Can you identify thickened tissue or fibrous bands along the sides or back of the neck?", "Is there an abnormality affecting the musculoskeletal system in the lateral neck area?", "Does the image display features that could impact the lymphatic system near the cervical region?", "Are the superficial or posterior cervical lymph nodes visible or displaced in the neck?", "Can you see any changes in the skin or subcutaneous connective tissue along the lateral neck?", "Is there a structure that appears anatomically contiguous with the cervical vertebrae and extends laterally?", "Are the trapezius or sternocleidomastoid muscles adjacent to a region of abnormal skin folding?", "Does the image include the platysma muscle near an area of thickened or folded skin?", "Are the clavicles or cervical vertebrae associated with an unusual tissue extension in the neck?", "Is there a feature in the neck region that could be associated with Turner syndrome or Noonan syndrome?"], "contexual_behavior": ["Does the image show a cervical region where skin folds or fibrous tissue might restrict movement, especially during periods of rapid growth?", "Can you identify a neck structure where redundant skin or tissue could compress lymphatic vessels and potentially reduce lymphatic drainage in certain postures?", "Is there evidence of excess tissue in the upper neck that could encroach on the airway, particularly when lying in a supine position during sleep?", "Does the lateral aspect of the neck appear to have folds that might limit extension, rotation, or flexion during physical activity?", "Can you see thickened tissue in the neck that could compress superficial veins or arteries and potentially alter blood flow during exercise?", "Is there a neck configuration that might increase susceptibility to recurrent respiratory infections due to impaired lymphatic drainage or airway narrowing?", "Does the image show tissue redundancy in the neck that could impinge on the pharynx or esophagus, possibly contributing to swallowing difficulties under stress?", "Is there visible tightness or restriction in the neck region that could exacerbate functional limitations during puberty or periods of rapid growth?", "Can you identify excess skin in the neck area that might hinder heat dissipation and impair thermoregulation in hot environments?", "Does the neck structure appear to compound structural or physiological deficits in the presence of other congenital anomalies, potentially worsening functional impairment?"], "functions": ["Does the image show evidence of limited neck mobility, such as restricted range of motion or visible skin folds?", "Can you identify excess skin or fibrous tissue in the neck region that might reduce lateral flexion or rotation?", "Is there a visible abnormality in head or neck posture, such as a forward head position, that could be due to restricted soft tissue mobility?", "Does the image suggest the presence of inelastic tissue bands affecting cervical spine biomechanics?", "Are there signs of superficial vein compression or venous congestion in the neck area?", "Can you observe features that might indicate impaired lymphatic drainage, such as localized swelling suggestive of lymphedema?", "Is there any indication of mild compromise to airway patency, without evidence of significant obstruction?", "Does the image suggest possible interference with swallowing or speech due to tissue impingement on pharyngeal or laryngeal structures?"]}, "no_questions": {"contexual_properties": ["Does the image show any localized fluid accumulation that could correspond to a cyst, abscess, or edema?", "Can you see any region with reduced volume, possibly due to atrophy or tissue degeneration?", "Can you identify regions where tissue appears to be missing, which could result from necrosis, infarction, or surgical removal?"], "properties": ["Is there a region where the density of cells varies, reflecting differences in tissue type or anatomical region?", "Does the specimen display pink and purple hues, as would be expected with hematoxylin and eosin staining?", "Is there a region in the image where cellular structures are clearly visible with moderate to strong staining intensity?"], "relational": ["Does the image show organ systems such as the nervous, respiratory, digestive, or reproductive systems in a side view?", "Are anatomical landmarks like the midline, nasal septum, or vertebral bodies visible in a longitudinal orientation?", "Does the image reveal separation between left and right structures, such as the two cerebral hemispheres or nasal cavities?"], "contexual_behavior": ["Does the image provide a clear view of spinal cord deformation or narrowing that would be useful for assessing cord compression?", "Is there any indication that tissue swelling or edema is obscuring normal anatomical landmarks?", "Is there evidence of structural disruption or hemorrhage that could indicate trauma and altered organ function?"], "functions": ["Can you trace the course of neural or vascular structures relative to midline landmarks in this view?", "Can you identify how organs and tissues are arranged from front to back in this image?", "Is there evidence of dynamic interactions between organs, such as tongue movement during speech or lung expansion?"]}}, "nipple duplication": {"yes_questions": {"contexual_properties": ["Is there a structure that appears more prominent, possibly due to hormonal changes such as those occurring during puberty or pregnancy?", "Can you identify an area that shows a change in size, which might be associated with puberty, pregnancy, or lactation?", "Does the image reveal a region with altered color or increased pigmentation, potentially linked to puberty, pregnancy, or skin conditions?", "Is there a visible structure that appears enlarged, which could be related to pregnancy, puberty, or hormonal therapy?", "Can you see an area that seems reduced in size, possibly following surgery or a decline in hormonal levels?", "Is there evidence of abnormal tissue composition, suggesting developmental anomalies or neoplastic changes?", "Does the image show pigmentation changes that might be associated with puberty, pregnancy, or dermatological disorders?", "Is there a region that appears swollen, which could be due to inflammation, infection, or trauma?", "Can you observe changes in texture, such as thickening or irregularity, that might result from inflammation, fibrosis, or skin disorders?", "Is there a structure that seems to contain additional glandular tissue, possibly due to embryological development or hormonal stimulation?", "Does any area appear more noticeable, potentially as a result of hormonal changes like those during puberty, pregnancy, or lactation?", "Is there a region showing signs of inflammation, such as redness or swelling, possibly due to infection, irritation, or autoimmune conditions?", "Can you identify a structure with a change in shape, which might be caused by growth, trauma, or underlying pathology?", "Is there evidence of discharge from a structure, which could be related to infection, hormonal stimulation, or cystic changes?", "Does any area appear tender or sensitive, possibly due to inflammation, hormonal changes, or physical irritation?"], "properties": ["Does the image show a small, round or oval structure measuring between a few millimeters and about one centimeter?", "Can you identify a feature whose color closely matches the surrounding areolar or nipple tissue, ranging from pink to brown?", "Is there a slightly raised, soft structure with a texture similar to normal nipple tissue visible in the image?", "Does the image contain one or more small, nipple-like projections along the chest or abdomen, possibly following the embryonic milk line?", "Can you see a structure with a diameter between 2 and 10 millimeters and a height less than 5 millimeters?", "Is there a feature whose pigmentation level is similar to that of a normal nipple or areola?", "Does the image show a structure with mild to moderate vascularity, consistent with normal skin and nipple tissue?", "Can you identify a small projection that may contain epidermal, dermal, or rudimentary glandular tissue?", "Is there evidence of a structure with tissue density ranging from soft to firm, resembling that of normal nipple tissue?", "Does the image show one or more small, nipple-like features that are either symmetrical or asymmetrical in their arrangement?", "Can you see a structure that may have hair follicles, with a frequency similar to the adjacent skin?"], "relational": ["Does the image show an abnormality affecting the integumentary system?", "Can you identify more than one structure resembling a nipple or areola on the chest or abdomen?", "Is there evidence of duplicated anatomical features along the embryonic milk line?", "Does the image display additional nipple-like structures adjacent to a normal nipple and areola?", "Can you see duplicated features involving both the epidermis and dermis?", "Is there a region where glandular tissue appears to be associated with an extra nipple-like structure?", "Does the image contain signs of supernumerary nipples or accessory breast tissue?", "Can you observe duplicated structures that might be explained by persistence of the mammary ridge?", "Is there an area where the skin shows features of both normal and duplicated nipple anatomy?", "Does the image reveal any duplicated structures that could be linked to embryonic development of the milk line?"], "contexual_behavior": ["Does the image show any features that could impair normal lactation due to the presence of additional glandular tissue?", "Is there evidence of structures that might alter the breast\u2019s response to hormonal changes during puberty?", "Can you identify any features that could affect the sensory function of the breast, such as abnormal innervation?", "Does the image contain anatomical variations that might interfere with breastfeeding efficiency or infant latching?", "Are there visible characteristics that could increase the risk of infection or inflammation in the breast tissue?", "Can you see any structures that might result in abnormal milk secretion patterns due to connections with functional ducts?", "Is there evidence of disrupted milk duct drainage, possibly caused by malformed or obstructed accessory ducts?", "Does the image show features that could lead to altered nipple erection in response to cold or stimulation?", "Are there any signs that the protective barrier function of the nipple-areolar complex might be compromised by additional structures?", "Can you identify anatomical variations that could complicate healing or increase the risk of scarring after breast injury or surgery?"], "functions": ["Is there a benign anatomical variation present that appears to have minimal impact on function?", "Can you identify an accessory structure that is unlikely to interfere with lactation due to a lack of developed glandular tissue?", "Does the image show an additional feature whose presence does not seem to affect the physiological role of the breast?", "Is there an area where sensory function might be normal or only slightly altered, possibly due to accessory tissue?", "Can you see a structure that may respond to hormonal changes during puberty or pregnancy, but less so than the primary feature?", "Is there an accessory structure present that does not appear to have the ductal or glandular components necessary for milk or colostrum secretion?", "Does the image show an anatomical variation that does not compromise skin integrity or local immune defense?", "Is there evidence of an additional feature that does not affect the normal development or function of mammary glands unless associated with extra glandular tissue?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show a region with an oval or slightly rounded contour?", "Can you infer that the tissue water content is likely between 60 and 70 percent by weight?", "Is there evidence of relatively low muscle mass, with facial muscles comprising a small proportion of the tissue?"], "relational": ["Can you see sensory organs such as the eyes, nose, or mouth in the image?", "Does the region appear to receive innervation from cranial nerves such as the facial or trigeminal nerve?", "Does the image show a region located in the cephalic part of the body?"], "contexual_behavior": ["Does the image show a region where sensory perception might be reduced following injury to the trigeminal nerve?", "Does the image include a region that could exhibit impaired muscle movement after a stroke affecting facial nerve pathways?", "Can you see an area that might display increased blood flow during blushing or inflammation due to vasodilation?"], "functions": ["Does the image display a surface that could aid in heat dissipation or show signs of vasodilation for temperature regulation?", "Can you observe intact skin or mucous membranes that serve as a barrier against pathogens and contribute to immune defense?", "Can you see anatomical elements that participate in breathing or olfactory detection through airflow and odor sensing?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Is there an abnormal head circumference, such as microcephaly or macrocephaly, suggesting neurodevelopmental disorders?", "Are there signs of organ enlargement that might be associated with metabolic disorders or congenital infections?", "Does the image show abnormal skin color that might be associated with anemia, hypoxia, or a genetic syndrome?"], "properties": ["Is there a visible structure whose blood glucose level could be between 20 and 60 mg/dL?", "Is there a structure that would have low fat content early on, increasing to about 16% of its body weight by the end of development?", "Does the image show an entity that could have an oxygen saturation level between 50% and 70% due to placental gas exchange?"], "relational": ["Does the image show a structure that could be in either the embryonic or fetal period of development?", "Can you identify features such as a neural tube, heart tube, or limb buds in the image?", "Is the central structure located within a cavity like the amniotic or chorionic cavity?"], "contexual_behavior": ["Can you identify signs of altered metabolic rate that could be due to maternal fasting, particularly in late pregnancy?", "Does the image indicate increased red blood cell production, possibly as a response to anemia during periods of high oxygen demand?", "Is there evidence of immune system immaturity that could be associated with preterm birth before 37 weeks?"], "functions": ["Can you identify a region where cardiomyocyte differentiation or pacemaker activity might be establishing a heartbeat?", "Is there evidence of skeletal development, such as cartilage templates or ossification processes, in the structure?", "Can you see evidence of hormone synthesis, such as production of human chorionic gonadotropin, or influence on maternal endocrine function?"]}}, "basilar skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a fracture involving the base of the skull, particularly in bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Is there a fracture line at the cranial base that appears less than a few millimeters wide?", "Does the image reveal a break limited to the thickness of the cranial base bones, typically only a few millimeters deep?", "Can you see a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Is there a lucent line traversing the base of the skull visible on the image?", "Does the image show an air-fluid level or evidence of pneumocephalus near the base of the skull?", "Can you identify any signs of cerebrospinal fluid leakage in association with a skull base fracture?", "Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Does the image suggest a unilateral fracture at the base of the skull, rather than a bilateral one?", "Is the temporal bone involved in the observed skull base fracture?", "Can you estimate whether the displacement of the fracture at the skull base is minimal, less than 2 millimeters?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?", "Are there air-fluid levels present near the base of the skull, as seen in about 20% to 30% of such fractures?", "On CT imaging, is there a hypodense (lucent) line at the base of the skull relative to the surrounding bone?", "Can you observe bruising patterns such as blue or purple discoloration behind the ear or around the eyes, which may change to yellow-green as they resolve?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Can you identify abnormalities in the anterior, middle, or posterior cranial fossae?", "Is there any indication of injury near the course of cranial nerves like the olfactory, optic, or facial nerves?", "Does the image reveal changes involving foramina such as the foramen magnum or cribriform plate?", "Are there visible alterations adjacent to the inner ear, nasal cavity, or orbit?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?", "Is there evidence of communication between the cranial cavity and spaces such as the subarachnoid space or paranasal sinuses?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Are there signs of disruption in sinuses such as the sphenoid or ethmoid sinus?", "Can you identify exposure or compromise of anatomical pathways like cerebrospinal fluid pathways or the auditory canal?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a disruption in the structural integrity of the skull base that could compromise brain protection?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Can you identify features suggesting a breach between the nasal cavity and cranial cavity, such as a defect in the cribriform plate?", "Does the image reveal any signs that could explain cranial nerve deficits, such as those affecting facial movement, hearing, vision, or swallowing?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?", "Can you see any indications that might increase the risk of infection entering the central nervous system, such as a direct pathway for pathogens?", "Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Are there features present that could facilitate the development of a cerebrospinal fluid leak due to openings in the dura mater or bone?", "Is there any sign of functional impairment, such as altered consciousness, seizures, or focal neurological deficits, that could be explained by a structural abnormality at the skull base?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify evidence of a study that visualizes the gastrointestinal tract using X-ray imaging?", "Does the image depict a diagnostic procedure involving the use of a radiopaque contrast agent?", "Is there a visible indication of a process designed to enhance the contrast of internal digestive structures for radiographic examination?"], "relational": ["Is there evidence of a substance outlining the lumen of the gastrointestinal tract?", "Can you see anatomical pathways that begin at the oral cavity and continue through the pharynx and esophagus?", "Does the image show a procedure that highlights regions such as the esophagus, stomach, or colon?"], "contexual_behavior": ["Does the image depict a diagnostic procedure involving the use of a radiopaque contrast agent?", "Can you identify evidence of a study that visualizes the gastrointestinal tract using imaging techniques?", "Is there a visible indication of a substance enhancing the contrast of internal digestive structures on the image?"], "functions": ["Does the image provide information about motility or peristaltic activity in the digestive tract by showing the transit of a visible substance?", "Can you compare this image to previous ones to assess changes in lesions or structural abnormalities over time?", "Is it possible to evaluate the shape, movement, or transport function of the esophagus, stomach, or intestines based on the image?"]}}, "lateral view of head": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling that could indicate edema, cellulitis, or a tumor?", "Can you observe any thickening of bone that might suggest disorders such as Paget\u2019s disease, chronic osteomyelitis, or fibrous dysplasia?", "Does the image show abnormal contours that could be due to craniofacial anomalies, fractures, or neoplastic processes?", "Is there a reduction in bone density that might be consistent with metabolic bone diseases like osteoporosis or hyperparathyroidism?", "Can you detect any asymmetry that could result from developmental disorders, trauma, or a space-occupying lesion?", "Is there visible soft tissue enlargement that may be related to infection, allergic reaction, or neoplastic infiltration?", "Do you see abnormal calcifications that could be associated with meningioma, vascular malformations, or chronic infections?", "Is there any indication of fractures, such as those of the skull, mandible, or facial bones, possibly due to trauma?", "Can you identify areas of increased opacity that might correspond to sinusitis, a neoplasm, or hemorrhage?", "Is there evidence of fluid levels within the sinuses that could suggest acute or chronic sinusitis or facial trauma?", "Do you observe bone loss that might be attributed to chronic infection, malignancy, or periodontal disease?", "Is there a visible abnormal mass that could represent a benign or malignant tumor, cyst, or abscess?", "Can you see displacement of anatomical structures that may result from trauma, expanding masses, or congenital anomalies?", "Are there changes in air spaces that could indicate sinus disease, trauma, or the presence of a mass?", "Do you notice abnormal bone growths that might be consistent with exostoses, osteomas, or bone-forming tumors?"], "properties": [], "relational": ["Does the image display anatomical regions such as the temporal, parietal, or zygomatic areas?", "Can you identify bones like the mandible, maxilla, or sphenoid bone in the image?", "Is there evidence of muscles such as the temporalis or masseter present in the depicted structures?", "Does the image show branches of cranial nerves like the facial or trigeminal nerve?", "Are facial features such as the external ear, cheek, or chin visible in the image?", "Can you observe the contours and relationships of cranial and facial bones from an external perspective?", "Does the image include vascular structures like the superficial temporal artery or external jugular vein?", "Are sensory organs such as the eye or nose present in the view?", "Can you identify soft tissues like skin, parotid gland, or subcutaneous tissue in the image?", "Is there a region in the image that overlies brain areas such as the temporal or occipital lobe?"], "contexual_behavior": ["Does the image show evidence of abnormal condylar translation or joint space narrowing that could indicate impaired jaw movement?", "Is there visible narrowing or collapse in the oropharyngeal region suggesting altered airway patency, as might be seen in sleep apnea?", "Can you identify mucosal thickening or opacification of the paranasal sinuses that would suggest reduced sinus ventilation?", "Does the image reveal deviations in skull shape or abnormal suture closure patterns that could indicate abnormal cranial growth?", "Is there malalignment of the dental arches or abnormal occlusal relationships that might point to impaired mastication?", "Can you see turbinate hypertrophy or narrowing of the nasal passages that could result in decreased nasal airflow?", "Does the image display delayed or incomplete movement of the hyoid bone or epiglottis, which might reflect changes in swallowing mechanics?", "Is there evidence of vertebral displacement or abnormal curvature suggesting altered cervical spine alignment?", "Can you observe abnormal positioning or movement of the tongue, palate, or jaw that could indicate impaired speech articulation?", "Does the image show joint space narrowing, erosions, or condylar deformities that would suggest reduced temporomandibular joint function?"], "functions": ["Does the image provide a perspective that reveals the spatial arrangement of organs responsible for vision, hearing, smell, and taste?", "Can you identify the anatomical pathways or exit points of nerves that pass through the skull and soft tissues from this viewpoint?", "Is there evidence of the alignment or movement of the jaw, teeth, or associated muscles involved in mastication?", "Does the image display the passage of air through structures such as the nasal cavity, pharynx, larynx, or trachea?", "Can you observe the coordination of the lips, tongue, soft palate, or larynx in relation to speech production?", "Is it possible to assess the oral cavity, pharynx, or esophagus during the swallowing process from this perspective?", "Does the image allow for the observation of facial muscles responsible for expressions or functional movements?", "Can you evaluate the movement or articulation of the temporomandibular joint during jaw opening or closing?", "Is there visibility of the external, middle, or inner ear structures involved in hearing or balance?", "Does the image permit assessment of airway openness by showing the relationship among the tongue, soft palate, and pharyngeal walls?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure whose phosphorus concentration is roughly 20\u201330 mg per 100 g of tissue?", "Can you see a gland that contains both chief cells and oxyphil cells?", "Does the image show a gland with a weight of about 30\u201350 milligrams?"], "relational": ["Can you identify small glands located near or on the posterior surface of the thyroid gland?", "Can you see any structures in proximity to the recurrent or superior laryngeal nerves?", "Is there a region surrounded by the thyroid capsule or connective tissue?"], "contexual_behavior": ["Is there a structure in the image that would increase hormone secretion to restore blood calcium levels during hypocalcemia?", "Does the image show a gland that could fail to regulate calcium homeostasis in the context of chronic kidney disease?", "Can you see a structure whose regulatory function may decrease with aging due to cellular senescence?"], "functions": ["Is there a gland visible that helps maintain neuromuscular function by regulating calcium necessary for nerve and muscle activity?", "Can you identify an object that adjusts its hormone output in response to changes in serum calcium and phosphate concentrations?", "Is there a structure that influences phosphate balance by promoting its excretion through the kidneys?"]}}, "fractures brain": {"yes_questions": {"contexual_properties": ["Does the image show evidence of swelling in brain tissue that could indicate disruption of the blood-brain barrier?", "Is there any sign of increased pressure within the cranial vault, such as swelling, bleeding, or fluid accumulation?", "Can you identify areas of bleeding within the brain that might result from vascular injury or trauma?", "Does the image reveal changes in brain tissue density that could be due to hemorrhage, edema, or tissue damage?", "Is there visible displacement of brain structures, such as a midline shift or herniation, suggesting mass effect?", "Can you see signs of fluid accumulation in the brain, such as hydrocephalus or evidence of cerebrospinal fluid leakage?", "Is there a visible deformity of the skull, such as depression or displacement of bone segments?", "Does the image show compression of brain tissue, possibly caused by swelling, hematoma, or bone fragments?", "Can you identify regions where brain volume appears reduced, possibly due to tissue loss, necrosis, or atrophy?", "Are there changes in the color or appearance of brain tissue on imaging that could be attributed to hemorrhage or edema?", "Does the image suggest abnormal tissue composition in the brain, such as areas of hemorrhage, necrosis, or inflammation?", "Is there evidence that brain tissue appears edematous, possibly due to fluid accumulation or vascular injury?", "Can you see the formation of hematomas within or around brain tissue, such as epidural, subdural, or intracerebral hematomas?", "Does the consistency of brain tissue appear altered, such as being softer or firmer, which might result from edema, hemorrhage, or gliosis?", "Are there regions with abnormal signal intensity on MRI that could reflect hemorrhage, edema, or tissue damage?"], "properties": ["Does the image show any discontinuity or lucent line in the cortex of cranial bones such as the frontal, parietal, temporal, or occipital regions?", "Can you identify a linear, curvilinear, or irregular line within the cranial bones that could indicate trauma?", "Is there evidence of a depressed area in the skull extending below the inner table of the bone?", "Do you observe any regions where the density of the cranial bone appears decreased or disrupted compared to adjacent areas?", "Is there a visible fracture line that is less than 2 millimeters wide?", "Can you see bone fragments composed of cortical or cancellous bone, or small bone chips near the cranial vault?", "Does the image reveal a fracture line measuring from several millimeters to several centimeters in length?", "Are there any areas where the color of the bone appears pale white, yellowish, or shows red discoloration suggestive of hemorrhage?", "Is there a pattern consistent with a linear fracture, which is the most common type in the cranial region?", "Can you identify features suggestive of a basilar or diastatic fracture in the cranial bones?", "Is there minimal displacement of bone fragments, or do you observe several millimeters or more of depression in any region?", "Does the thickness of the skull at the suspected fracture site appear to be within the typical range of 4 to 8 millimeters for adults?", "Are there signs that could indicate the stage of healing, such as changes in bone continuity or density, that might suggest a healing time of several weeks?"], "relational": ["Does the image show disruption in any of the bones forming the cranial vault or skull base?", "Is there evidence of injury to regions such as the calvaria or orbital roof?", "Can you identify any abnormalities involving the frontal, temporal, parietal, occipital, or sphenoid bones?", "Is there a visible breach or discontinuity in the protective layers surrounding the brain, such as the meninges?", "Does the image suggest involvement of membranes like the dura mater, arachnoid mater, or pia mater adjacent to a bony defect?", "Are there signs that vascular structures like the middle meningeal artery or superior sagittal sinus may be at risk due to a nearby bone injury?", "Can you see any features indicating possible compromise of cranial nerves such as the olfactory or optic nerves?", "Is there evidence that anatomical compartments like the epidural or subdural spaces are exposed or affected?", "Does the image reveal disruption of tissues surrounding the brain, such as the scalp or periosteum?", "Are there visible fracture lines or pathways that could allow communication between bone and brain tissue?", "Can you identify any compromise to structures that normally protect the brain, such as cranial bones or cerebrospinal fluid?", "Is there any indication that the musculoskeletal or vascular systems are involved in the observed injury?", "Does the image suggest the presence of dural tears or involvement of skull foramina or sinuses?"], "contexual_behavior": [], "functions": ["Does the image show evidence of an injury that could result in neurological deficits or cognitive impairment?", "Can you identify any disruption that might affect neural pathways or specific brain region activities?", "Is there a visible abnormality that could explain attention deficits, memory impairment, or executive dysfunction?", "Does the image suggest damage that might lead to motor weakness, paralysis, or abnormal movements?", "Can you see any indication of an injury that could cause sensory loss, numbness, or abnormal sensory experiences?", "Is there evidence of disrupted connectivity between brain regions that might impair integrated brain functions?", "Does the image reveal a condition that could diminish consciousness or alertness, such as confusion or coma?", "Is there involvement of areas that might affect vital functions like breathing or heart rate, especially near the brainstem?", "Can you identify any damage to regions associated with memory formation and recall, such as the hippocampus?", "Does the image suggest injury that could result in mood disturbance, impulsivity, or personality change?", "Is there evidence of altered reflex responses, such as exaggerated or diminished reflexes?", "Can you see any abnormality that might affect language or speech abilities, leading to communication impairment?", "Does the image show involvement of regions responsible for coordination and balance, such as the cerebellum?", "Is there evidence of impaired sensory processing or misinterpretation of sensory input?", "Does the image suggest a condition that could lead to persistent disability or reduced independence in daily activities?"]}, "no_questions": {"contexual_properties": ["Are there any areas with color changes that might reflect hemorrhage or necrosis within the tissue?", "Are there abnormal regions with clear spaces or swelling, which could be due to edema or fluid accumulation?", "Are there cells with multiple nuclei or giant cells present within abnormal regions, suggesting cell fusion or abnormal mitosis?"], "properties": ["Can you spot something with a surface area close to 1875 square millimeters?", "Is there a structure that seems to be about 1 mm thick?", "Can you see an object that could be made of soda-lime glass or borosilicate glass?"], "relational": ["Is there any indication that this specimen could be part of a larger pathological collection, such as a case series or biorepository?", "Are there adjacent slides or specimens, such as control slides or immunohistochemistry slides, visible in the image?", "Does the image include tissue that could be associated with the integumentary, respiratory, gastrointestinal, or nervous systems?"], "contexual_behavior": ["Are there visible clusters of microorganisms or signs of microbial infiltration that would indicate heightened pathogen presence during infection?", "Are there visible signs of new blood vessel formation that could suggest angiogenesis in response to low oxygen levels?", "Are there indications of reduced phagocytic activity, such as an accumulation of debris or pathogens, that could be linked to immunodeficiency?"], "functions": ["Can you observe signs of tissue repair, fibrosis, or new tissue formation that might indicate healing or regeneration?", "Is there histopathological information present that could support clinical decision-making or guide lesion management?", "Can you identify evidence of cellular or structural abnormalities that might indicate a pathological process?"]}}, "ear lobe crease": {"yes_questions": {"contexual_properties": ["Is there a visible crease that appears deeper or more prominent in individuals with signs of aging or decreased skin elasticity?", "Can you identify a feature that is more noticeable in people with cardiovascular risk factors or as part of the natural aging process?", "Does the image show a crease with altered color, possibly indicating local trauma, bruising, or vascular changes?", "Is there a visible line that appears wider, potentially due to loss of subcutaneous fat or collagen?", "Can you see a crease present in both ears, which might be more common in older adults or those with systemic conditions?", "Is there a feature that becomes more visible with cumulative skin changes associated with increasing age?", "Does the image show a crease that appears less noticeable, possibly due to improved skin turgor or cosmetic procedures?", "Can you identify an asymmetrical crease that could be related to unilateral sleeping habits, trauma, or localized skin changes?", "Is there a visible line associated with thinning of the skin, possibly due to aging or dermatological disease?", "Does the crease show changes in texture that might be due to chronic sun exposure, skin disorders, or scarring?", "Is there swelling near a crease that could suggest local infection, allergic reaction, or trauma?", "Can you see a crease that appears to have developed suddenly, possibly following acute trauma or rapid changes in skin integrity?", "Does the image show a crease with discoloration that could be linked to bruising, vascular compromise, or pigmentation disorders?", "Is there a more pronounced crease that might be associated with dehydration and reduced skin turgor?", "Can you identify a crease that has changed in appearance following weight loss, possibly due to diminished subcutaneous fat?"], "properties": ["Is there a linear or diagonal marking visible across the anterior surface of the ear lobe, running from the tragus to the lower edge?", "Can you identify a shallow indentation, less than 1 millimeter deep, on the ear lobe?", "Does the image show a marking on the ear lobe that is between 1 and 2 centimeters in length?", "Is there a feature on the ear lobe that appears 1 to 3 millimeters wide?", "Can you see a marking on the ear lobe whose color matches the surrounding skin or is slightly darker?", "Does the texture of the ear lobe show a smooth but indented line compared to adjacent skin?", "Are there similar markings present on both ear lobes, suggesting a bilateral appearance?", "Is there a visible feature on the ear lobe that is more likely to appear in individuals over 40 years of age?", "Does the image show a marking on the ear lobe that is consistent with a feature found in 20\u201330% of adults?", "Can you identify whether the marking on the ear lobe is unilateral or bilateral, and if so, does it match the higher prevalence of bilateral cases?"], "relational": ["Is there a linear fold or indentation visible within the tissue of the auricle?", "Can you identify a superficial feature formed in the skin of the external ear?", "Does the image show a morphological variant located on the lower part of the auricular region?", "Is there a visible skin fold adjacent to the margin of the ear lobe and the cheek skin?", "Can you see a structure in the auricular region that contains epidermis, dermis, adipose tissue, and connective tissue?", "Does the image display a feature that could be supplied by branches of the posterior auricular or superficial temporal arteries?", "Is there a visible fold in the ear lobe area that might be innervated by the great auricular or auriculotemporal nerve?", "Can you identify a linear indentation among other features such as piercing sites or pigmentation spots on the ear lobe?"], "contexual_behavior": ["Does the image show a feature that becomes more pronounced in individuals with increased vascular aging or arterial stiffness?", "Is there a visible sign that may persist even after improvements in metabolic health due to underlying structural changes in connective tissue?", "Can you identify a feature that tends to deepen with aging as elastin and collagen fibers degrade?", "Does the image contain a characteristic that can appear or worsen in response to chronic stress and prolonged exposure to elevated cortisol?", "Is there a visible indicator that correlates with impaired microcirculation or compromised capillary blood flow?", "Can you see a feature that is more prominent in individuals with diabetes as a result of microvascular complications and connective tissue glycation?", "Does the image show a sign that may develop or progress during systemic atherosclerosis due to chronic arterial narrowing and reduced tissue perfusion?", "Is there a feature that could change in appearance after weight loss or lifestyle modification if vascular health and skin elasticity improve?", "Can you identify a characteristic that becomes less prominent following improved cardiovascular function and restored tissue perfusion?", "Does the image contain a visible sign that may indicate altered connective tissue behavior in metabolic syndrome due to changes in the extracellular matrix and chronic inflammation?"], "functions": ["Does the image show an anatomical variation that does not have a known function?", "Can you identify a visible feature that serves as an anatomical marker without participating in physiological processes?", "Is there a crease present that has been studied as a potential clinical indicator of increased cardiovascular risk?", "Does the image display a feature that may reflect alterations in vascular or connective tissue integrity?", "Can you see a structure that could be associated with age-related changes or microvascular pathology?"]}, "no_questions": {"contexual_properties": ["Do any cells appear to contain an increased number of organelles, suggesting high metabolic activity or differentiation?", "Do any cells exhibit altered cytoplasmic color or staining, possibly due to metabolic changes or pigment accumulation?", "Does the image show cells with increased volume suggestive of hypertrophy or active protein synthesis?"], "properties": ["Is there evidence of a cell with elevated RNA content in the cytoplasmic region?", "Is there a cell with a cytoplasmic area that might contain glycogen granules or show low carbohydrate concentration?", "Can you see a cell where the cytoplasmic density appears slightly greater than water?"], "relational": ["Does the image show glandular epithelium, hematopoietic tissue, or reticuloendothelial tissue?", "Are there cellular components such as cytosol, cytoskeletal elements, vesicles, or inclusions visible within the cells?", "Does the image contain anatomical structures like the liver, salivary glands, or lymph nodes?"], "contexual_behavior": ["Is there evidence of altered signal transduction, such as changes in second messenger pathways or protein localization, during inflammation?", "Is there evidence of enhanced detoxification, such as upregulation of antioxidant enzymes or glutathione synthesis, during oxidative stress?", "Does the image display a region with increased organelle content, suggesting active cell growth or proliferation?"], "functions": ["Does the image show a cell where energy production could be enhanced by the distribution of mitochondria?", "Does the image display a cell with sufficient space for optimal organelle maintenance and activity?", "Can you identify a cell where protein synthesis might be particularly active due to increased ribosome density?"]}}, "slide?": {"yes_questions": {"contexual_properties": ["Is there an object in the image that shows signs of surface abrasion or scratches?", "Can you identify a structure that appears to have residue or contamination from biological material or cleaning agents?", "Does any object display color changes that could result from the application of stains or dyes?", "Is there evidence of cracks or structural damage that might be caused by mechanical stress or improper handling?", "Can you see an area that appears cloudy, possibly due to moisture or degraded mounting medium affecting optical clarity?", "Is there a region where the mounting medium appears excessively thick?", "Does any structure show reduced transparency, potentially due to surface damage or mounting medium deterioration?", "Can you identify an object that appears contaminated with dust, microorganisms, or foreign substances?", "Is there visible accumulation of deposits, such as salts or proteins, on any surface?", "Does any area exhibit altered optical properties, such as changes in refractive index, possibly due to changes in the mounting medium or specimen?", "Is there evidence of warping or deformation, potentially from excessive heat or uneven drying?", "Can you see dust or particulate accumulation on any surface, suggesting exposure to unfiltered air or improper storage?", "Does any specimen appear faded in color, possibly due to prolonged light exposure or chemical instability?", "Is there a visible change in specimen size that might indicate dehydration, swelling, or chemical reactions?", "Can you identify any specimen that shows morphological distortion or artifacts, possibly resulting from fixation, staining, or mounting procedures?"], "properties": ["Is there an object in the image that appears rectangular and measures approximately 75 mm by 25 mm?", "Can you identify a structure that is about 1 mm thick?", "Does the image show something that is colorless and highly transparent?", "Is there an object with a smooth, polished surface visible?", "Can you see a structure that could be made of glass or plastic?", "Is there an item that seems to have a density close to 2.5 g/cm\u00b3?", "Does the image contain an object that could weigh around 5 grams?", "Is there a transparent object suitable for use in light microscopy?", "Can you identify something that would have negligible water absorption?", "Is there an object that is resistant to most chemicals but might be sensitive to strong acids or bases?", "Does the image show a structure that could withstand temperatures up to about 500\u00b0C?", "Can you see an object whose refractive index might be approximately 1.52?", "Is there a rectangular structure with a standard length of 75 mm?", "Does the image include an object with a standard width of 25 mm?"], "relational": ["Does the image show a specimen holder that could be examined under a microscope?", "Can you identify any tissues or cells, such as epithelial or blood cells, that might be present for microscopic analysis?", "Is there evidence of microorganisms or microbial cultures prepared for examination?", "Does the image contain any body fluids, like blood or cerebrospinal fluid, that could be analyzed in a laboratory setting?", "Can you see any features suggesting the presence of biopsy samples or cytology smears?", "Is there a specimen that could be part of a histopathology or cytology diagnostic process?", "Does the image show evidence of staining techniques, such as hematoxylin and eosin or Gram stain, used to highlight cellular structures?", "Are there anatomical regions, such as skin, lung, or kidney, represented in the specimen?", "Can you identify cellular components like nuclei, cytoplasm, or organelles within the sample?", "Is there a thin tissue section that appears to be prepared for microscopic examination?"], "contexual_behavior": ["Is there evidence of foreign material or microorganisms that could indicate compromised sample integrity?", "Can you observe any artifacts, cell shrinkage, or lysis that might result from improper staining conditions?", "Does the sample appear to have poor tissue adhesion, possibly due to moisture interference from a high humidity environment?", "Is there any indication that the clarity or preservation of the sample is affected by the choice of mounting media, such as changes in refractive index?", "Can you detect surface scratches or residue accumulation that might suggest the object has been used repeatedly, affecting visualization quality?", "Are there signs of desiccation, microbial growth, or chemical degradation that could result from prolonged storage and impact sample integrity?", "Does the sample show evidence of antigen loss or poor antibody binding, which might indicate inadequate fixation affecting immunohistochemical analysis?", "Is there a noticeable reduction in fluorescent signal intensity that could be due to photobleaching from intense light exposure?", "Can you see uneven cell distribution or poor interpretability that might result from suboptimal spreading during cytological preparation?", "Are there visual cues suggesting the presence of interfering substances that could mask or alter target structures, impacting pathogen detection?"], "functions": ["Is there an object in the image that serves as a flat support for mounting biological specimens?", "Can you identify a transparent platform that would allow light to pass through a specimen for microscopic observation?", "Does the image show something that could stabilize a biological sample for examination under a microscope?", "Is there a structure present that enables the clear arrangement and spreading of cells for visualization?", "Can you see an object that would support the detection of pathogens or abnormalities by presenting samples in a thin, observable layer?", "Is there a platform visible that facilitates the even application and adherence of stains during sample preparation?", "Does the image contain something that enables thin sectioning and clear observation of tissue architecture?", "Is there a surface present that would allow for the assessment of blood smears or cytology samples by providing a uniform area for spreading cells?", "Can you identify an object that helps preserve the integrity of a sample by minimizing contamination and physical disruption?", "Is there a structure that assists in the quantification of cells or microorganisms by providing standardized fields of view for counting?"]}, "no_questions": {"contexual_properties": ["Do any cells display prominent nucleoli, as might be seen in actively proliferating malignant cells or certain viral infections?", "Can you identify abnormal chromatin patterns that could be seen in carcinoma or high-grade dysplasia?", "Are there abnormal cell borders visible, which could be seen in invasive carcinomas or during epithelial-mesenchymal transition?"], "properties": ["Do any cells display coarse, clumped, or unevenly distributed chromatin patterns?", "Are abnormal mitotic figures more frequent in this image than would be expected in normal tissue?", "Are prominent or enlarged nucleoli visible within any of the nuclei?"], "relational": ["Is there a sample from the reproductive, gastrointestinal, or respiratory system where abnormal cellular features could be present?", "Are there anatomical sites such as the prostate, cervix, breast, or colon in the image that might be prone to cellular abnormalities?", "Is there a region in the image where cells show variation in size and shape or an increased nuclear-to-cytoplasmic ratio?"], "contexual_behavior": ["Does the image display progression of abnormal cell features consistent with malignant transformation?", "Are there signs of worsening cellular abnormalities in regions with evidence of viral infection?", "Is there an increase in abnormal cell morphology in regions exposed to radiation therapy?"], "functions": ["Does the image show evidence of abnormal cellular function that could indicate an increased risk for malignant transformation?", "Does the image reveal disruption in the regulation of cell growth, such as failure of normal checkpoints or signaling pathways?", "Can you identify areas where cells display irregular growth patterns or a loss of normal differentiation?"]}}, "brain": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears swollen, which could indicate conditions like cerebral edema or infection?", "Is there evidence of shrinkage or reduced size in a structure that might be associated with aging or neurodegenerative diseases?", "Can you identify an area with decreased volume that could be related to disorders such as Alzheimer's disease or malnutrition?", "Does the image reveal abnormal lesions that might suggest multiple sclerosis, stroke, or a tumor?", "Is there visible accumulation of fluid within a structure, as seen in hydrocephalus or meningitis?", "Can you detect regions with increased iron deposition, which may occur in neurodegenerative diseases like Parkinson's disease?", "Is there a change in color, such as pallor or discoloration, that could result from hypoxia or hemorrhage?", "Does the structure appear softer than normal, possibly due to liquefactive necrosis or severe hypoxic injury?", "Is there evidence of increased firmness, which might be caused by chronic gliosis or calcification?", "Can you see plaques or deposits that are characteristic of Alzheimer's disease or demyelinating disorders?", "Are there increased white matter lesions visible, which could be associated with aging or small vessel disease?", "Does the image suggest atrophy, as seen in chronic neurodegenerative diseases or after prolonged injury?", "Is there any indication of increased intracranial pressure, such as compression or displacement of adjacent structures?", "Can you identify hemorrhages that might be due to hypertension, trauma, or coagulopathies?", "Is there evidence of abnormal electrical activity, which could be related to epilepsy or encephalopathy?", "Can you detect amyloid accumulation, as seen in Alzheimer's disease or cerebral amyloid angiopathy?", "Does the structure display abnormal tissue density, which may be present in stroke, tumors, or demyelinating diseases?", "Is there a region with altered metabolic activity, either increased or decreased, that could suggest epilepsy, tumors, or neurodegenerative diseases?", "Can you see calcifications that might be due to congenital infections, metabolic disorders, or chronic infarcts?", "Is there evidence of changes in neurotransmitter-related features, which could be associated with psychiatric disorders or Parkinson's disease?"], "properties": ["Is there a structure in the image that has an irregular, convoluted surface with visible gyri and sulci?", "Can you identify an object that appears pale grayish-pink in color?", "Does the image show a structure whose size could be approximately 15 centimeters in length and 14 centimeters in width?", "Is there an object present that could have a volume between 1,200 and 1,500 milliliters?", "Can you see a structure that is likely to contain cell types such as neurons, astrocytes, or oligodendrocytes?", "Is there evidence of a region that could contain around 86 billion neurons?", "Does the image include a structure where the number of glial cells might be roughly equal to or slightly greater than the number of neurons?", "Can you identify an object that might have a gray matter to white matter ratio of about 1.3 to 1?", "Is there a structure that could have a water content of approximately 75% to 80% by weight?", "Does the image show an object that might have a lipid content of about 10% to 12% of its wet weight?", "Is there a region that could contain myelin making up about 20% of its dry weight?", "Can you see a structure that might have a cholesterol content of 15 to 20 milligrams per gram of tissue?", "Is there an object that could have an iron concentration ranging from 30 to 60 micrograms per gram, depending on the region?", "Does the image include a structure that typically maintains a temperature between 36.5 and 38 degrees Celsius?", "Can you identify an object that would normally have a pH between 7.1 and 7.4?", "Is there a region that could consume oxygen at a rate of about 3.5 milliliters per 100 grams per minute?", "Does the image show a structure where the glucose concentration might be between 0.7 and 2.5 millimoles per liter?", "Can you see an object that would likely have a protein content of approximately 8% to 10% of its wet weight?", "Is there a structure present that could weigh between 1,300 and 1,400 grams in an adult human?"], "relational": ["Does the image show a structure that is part of the nervous system?", "Can you identify regions such as the cerebrum, cerebellum, or brainstem in the image?", "Is there a structure that connects directly to the spinal cord via the brainstem or medulla oblongata?", "Are protective membranes like the dura mater, arachnoid mater, or pia mater visible surrounding any structure?", "Does the image include blood vessels such as the internal carotid arteries or vertebral arteries supplying a central organ?", "Can you see internal cavities resembling ventricles, such as the lateral, third, or fourth ventricle?", "Is there evidence of cranial nerves, such as the optic nerve or other nerves originating from a central structure?", "Does the image show a structure protected by the bones of the cranium or skull?", "Are there areas distinguishable as gray matter or white matter within a central organ?", "Can you identify neural tissue or glial cells within any structure present?", "Is there a principal organ of the central nervous system coordinating with the spinal cord visible in the image?"], "contexual_behavior": ["Does the image show a structure that reduces its processing speed during normal aging or neurodegenerative conditions?", "Can you identify an area that would increase neural activity in response to stress via the hypothalamic-pituitary-adrenal axis?", "Is there a structure whose memory formation could be impaired by sleep deprivation affecting REM and slow-wave sleep?", "Does the image contain a region where neurotransmitter release, such as serotonin, norepinephrine, or dopamine, might be decreased in depression?", "Can you see an area that enhances synaptic plasticity during learning through mechanisms like long-term potentiation?", "Is there a structure that fails to regulate motor control in Parkinson\u2019s disease due to degeneration of dopaminergic neurons?", "Does the image show a region that would increase glucose uptake during intense mental activity?", "Can you identify a structure that reduces oxygen consumption during anesthesia as neural activity decreases?", "Is there an area that alters its function during hypoxia by shifting to anaerobic metabolism and reducing neuronal activity?", "Does the image contain a region that shows decreased responsiveness under sedation due to suppression of cortical and subcortical activity?", "Can you see a structure that increases pain perception in chronic pain conditions through central sensitization?", "Is there an area that fails to coordinate sensory input after injury when neural pathways are disrupted by trauma or stroke?", "Does the image show a region that enhances neuroprotection during mild hypothermia by reducing metabolic demand?", "Can you identify a structure that reduces executive function during aging as prefrontal cortex efficiency declines?", "Is there an area that increases neuroinflammation in neurodegenerative diseases due to activation of microglia and astrocytes?", "Does the image contain a region that alters its activity during meditation by modulating the default mode network and increasing alpha wave activity?", "Can you see a structure that shows impaired signal transmission in multiple sclerosis due to demyelination of central nervous system axons?", "Is there a region that increases blood flow during physical exercise to supply active neurons with oxygen and nutrients?", "Does the image show a structure that reduces its ability to regulate emotions in anxiety disorders due to dysregulation of limbic and prefrontal circuits?", "Can you identify an area that fails to maintain homeostasis during severe trauma when autoregulatory mechanisms are overwhelmed?"], "functions": ["Does the image contain a structure responsible for cognition and perception?", "Is there an object that controls movement by sending signals to muscles?", "Can you identify a region involved in processing sensory information?", "Does the image show structures such as the amygdala or limbic system that regulate emotions?", "Is there a visible area associated with memory formation, such as the hippocampus?", "Can you see regions like the basal ganglia or cerebellum that coordinate voluntary actions?", "Does the image include a structure that regulates hormone release through the pituitary gland?", "Is there an area related to language comprehension or production, such as Broca\u2019s or Wernicke\u2019s area?", "Can you identify a region that maintains homeostasis by adjusting bodily functions?", "Does the image show centers like the medulla oblongata or brainstem involved in regulating breathing and heart rate?", "Is there a structure supporting learning and cognition through neural plasticity?", "Can you see association areas that integrate information from multiple senses?", "Is there a region involved in regulating sleep and circadian rhythms?", "Does the image contain a structure that participates in the stress response by activating the HPA axis?", "Can you identify an area involved in decision making, such as the prefrontal cortex?"]}, "no_questions": {"contexual_properties": ["Does the image suggest a decreased body mass index due to loss of both muscle and fat?", "Can you identify signs of muscle wasting or reduced muscle mass in the context of persistent inflammation?", "Can you observe visible loss of subcutaneous tissue or wasting in the context of advanced chronic illness?"], "properties": [], "relational": ["Are there signs of fibroblast activity or tissue remodeling in the depicted structures?", "Does the image show organs such as the liver, heart, pancreas, or gastrointestinal tract that might be affected by a wasting process?", "Can you observe disruption at multiple structural levels, such as cells, tissues, and organs?"], "contexual_behavior": [], "functions": ["Is there any indication of appetite suppression or anorexia, such as visible signs of poor nutritional status?", "Does the image suggest elevated inflammation, such as features consistent with chronic illness or immune activation?", "Can you identify signs of reduced physical performance or functional decline?"]}}, "slide": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image contain an object with a rectangular shape measuring approximately 75 mm by 25 mm?", "Can you identify a transparent, colorless object that allows most visible light to pass through?", "Is there a structure present that appears to be made of glass?", "Does the image show an object with a thickness of about 1 mm?", "Can you see something that could have a surface area close to 1875 square millimeters?", "Is there an object whose refractive index is likely around 1.52?", "Does the image include an item that is highly resistant to most chemicals except strong acids and bases?", "Can you identify an object that would have negligible water absorption?", "Is there a structure that could withstand temperatures up to about 500 degrees Celsius?", "Does the image contain an object with an average weight of around 5 grams?", "Can you see something with a density close to 2.5 grams per cubic centimeter?"], "relational": ["Does the image show a platform that could be used to hold tissue sections or cells for microscopic examination?", "Is there an object present that might support the observation of microorganisms under a microscope?", "Can you identify a structure that could be associated with epithelial tissue, blood cells, or muscle tissue prepared for analysis?", "Does the image contain a specimen that appears to be mounted with a coverslip?", "Is there evidence of a mounting medium or coverslip being used to protect a biological sample?", "Can you see any indication of stains such as hematoxylin and eosin, Gram stain, or PAS stain applied to a specimen?", "Is there a component that could be placed on a microscope stage or held by a slide holder?", "Does the image include elements commonly found in pathology, hematology, or microbiology laboratory diagnostics?", "Is there an association between a flat transparent object and a thin protective layer placed over a specimen?", "Can you identify a sample that resembles a blood smear, tissue biopsy, or cytology preparation?", "Does the image contain material that could represent anatomical regions such as lung, breast, lymph node, or colon for pathological examination?"], "contexual_behavior": ["Does the image show a sample where poor contrast or obscured cellular details might indicate issues with staining quality?", "Can you identify evidence of tissue swelling or detachment that could result from exposure to high humidity?", "Is there any indication that cell adhesion to the surface is reduced, possibly due to the effects of a particular fixation protocol?", "Does the sample appear to have changes in optical clarity or refractive index that could be influenced by the choice of mounting media?", "Is there visible evidence of sample contamination or degradation that might result from inadequate sealing or prolonged storage?", "Can you detect signs of photobleaching in fluorescent regions, suggesting the sample has been exposed to intense light during fluorescence imaging?", "Does the image suggest compromised antibody binding, possibly due to suboptimal antigen retrieval in an immunohistochemistry procedure?", "Is there any indication of sample degradation or denaturation that could be associated with elevated temperature exposure?", "Can you observe variations in focus or image resolution that might be explained by differences in sample thickness during digital scanning?", "Does the image display spectral interference or overlapping signals that could result from multiplex staining with overlapping fluorophores?"], "functions": ["Does the image include an object that serves as a flat support for mounting biological samples?", "Can you identify a structure that enables the placement and stabilization of specimens for microscopic examination?", "Is there a surface present that is used for arranging and securing tissue specimens prior to analysis?", "Does the image show a platform that allows cells to be spread in a thin layer for clear visualization?", "Is there an object essential for displaying stained tissue sections during histological analysis?", "Can you see a structure that assists in detecting pathogens or abnormal cells by presenting samples for staining and observation?", "Does the image contain a tool used to prepare and examine cellular material in cytological studies?", "Is there a surface that supports the application and retention of stains to enhance contrast for microscopic evaluation?", "Can you identify an object that helps maintain the physical and chemical integrity of samples during analysis?", "Is there a platform that enables side-by-side placement and comparison of different tissue sections for diagnostic evaluation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify layers such as syncytiotrophoblast or cytotrophoblast in a tissue?", "Does the image display fetal blood vessels linked to another structure?", "Is there a visible connection between a structure and the umbilical cord?"], "contexual_behavior": [], "functions": ["Does the image contain a structure that facilitates oxygen diffusion to the fetus and carbon dioxide removal from fetal blood?", "Does the image show a structure responsible for transferring nutrients and gases between maternal and fetal blood?", "Is there a feature present that enables the movement of glucose, amino acids, fatty acids, or vitamins from mother to fetus?"]}}}
[ { "answer": "head tilted with mouth", "extracted_concepts": [ "mouth", "head tilted" ], "question": "what does this image show?" }, { "answer": "with mouth", "extracted_concepts": [ "mouth", "head tilted" ], "question": "how does this image show head tilted?" }, { "answer": "yes", "extracted_concepts": [ "mouth", "head tilted" ], "question": "does this image show head tilted with mouth?" }, { "answer": "no", "extracted_concepts": [ "head tilted", "mouth", "anencephaly" ], "question": "does anencephaly show head tilted with mouth?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "no", "extracted_concepts": [ "large cervical myoma", "uterus", "cervix", "vagina" ], "question": "is opened uterus and cervix with large cervical myoma protruding into vagina slide present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bilateral cleft palate" ], "question": "is bilateral cleft palate present?" }, { "answer": "no", "extracted_concepts": [ "newborn cord around neck" ], "question": "is newborn cord around neck present?" }, { "answer": "head tilted with mouth", "extracted_concepts": [ "head tilted", "mouth", "lesion", "large defect" ], "question": "what opened to show large defect very good illustration of this lesion?" }, { "answer": "to show large defect very good illustration of this lesion", "extracted_concepts": [ "lesion", "head tilted", "large defect", "mouth opened" ], "question": "what is head tilted with mouth opened?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" }, { "answer": "large", "extracted_concepts": [ "lesion", "defect", "head tilted", "mouth opened" ], "question": "how is head tilted with mouth opened to show defect very good illustration of this lesion?" }, { "answer": "good", "extracted_concepts": [ "lesion", "head tilted", "large defect", "mouth opened" ], "question": "how is head tilted with mouth opened to show large defect very illustration of this lesion?" } ]	["uterus", "mouth opened", "lesion", "head tilted", "bilateral cleft palate", "vagina", "mouth", "defect", "cervix", "large defect", "face", "large cervical myoma", "newborn cord around neck", "anencephaly"]	{"uterus": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify a region that could correspond to the fundus, body, isthmus, or cervix?", "Is there an organ located adjacent to the bladder or rectum?", "Does the image contain a structure positioned near the ovaries?", "Can you see blood vessels that might be the primary supply to a reproductive organ, such as the uterine artery or vein?", "Is there evidence of supporting ligaments like the broad ligament, round ligament, or uterosacral ligament?", "Does the image show a connection between the ovaries and another structure via tubular pathways?", "Can you identify features related to the menstrual or reproductive cycles?", "Is there a visible anatomical connection between a structure and the vagina?", "Can you see tissue layers that could correspond to the endometrium, myometrium, or perimetrium?", "Does the image show tubular structures connecting to a larger organ at the uterine cornua?", "Is there an organ located within the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image show a structure that supports embryo implantation or fetal development?", "Is there an organ present that undergoes cyclical changes in its lining in response to hormones?", "Can you identify a tissue that sheds periodically as part of menstruation?", "Does the image contain a structure that provides a protective environment for fetal growth?", "Is there evidence of an organ that expands during pregnancy to accommodate a growing fetus?", "Can you see a structure that supports placental attachment and maternal-fetal exchange?", "Is there an object that generates coordinated muscular contractions to facilitate childbirth?", "Does the image show a tissue that responds to hormones such as estrogen or progesterone?", "Is there a structure that produces secretory factors to facilitate embryo implantation?", "Can you identify an organ that forms a physical barrier and provides immunological protection for a developing fetus?", "Does the image contain a structure responsible for expelling menstrual blood and tissue?", "Is there evidence of rhythmic contractions under the influence of oxytocin to aid in delivery?", "Can you see a tissue that supplies nutrients and removes waste for fetal development?", "Is there an organ whose structural and functional changes are regulated by reproductive hormones?", "Does the image show a structure essential for fertility, pregnancy support, or menstrual health?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a staining pattern that primarily highlights smooth muscle cells or myofibroblasts?", "Does the image suggest detection of a protein with an approximate molecular weight of 42 kilodaltons?", "Does the image suggest that the staining was carried out at a temperature of about 20 to 25 degrees Celsius?"], "relational": ["Are anatomical boundaries like muscularis mucosae or tumor margins visually defined by the staining pattern?", "Does the image show histological structures such as smooth muscle bundles or pericytic layers that are specifically highlighted?", "Can you see areas where actin filaments in smooth muscle tissue are visually accentuated?"], "contexual_behavior": [], "functions": ["Is there evidence of smooth muscle differentiation or myofibroblast activation in the tissue?", "Are there areas indicating wound contraction or extracellular matrix deposition as part of tissue remodeling?", "Does the staining pattern reveal cells engaged in contractile or reparative processes associated with tissue remodeling?"]}}, "mouth opened": {"yes_questions": {"contexual_properties": ["Does the image show a person with a wider than normal opening, as might be seen during yawning or shouting?", "Is there evidence of restricted opening, which could be associated with temporomandibular joint disorders or trismus?", "Can you identify an individual whose opening appears increased, as might occur during laughter or singing?", "Does the image suggest a decreased opening that could be linked to conditions like oral submucous fibrosis or scleroderma?", "Is there a visible change in the shape of the opening, possibly due to facial nerve palsy or congenital anomalies?", "Does the opening appear asymmetrical, which might indicate unilateral muscle weakness or facial paralysis?", "Can you observe discoloration, such as bluish or pigmented changes, that could be due to cyanosis or pigmentation disorders?", "Is there swelling at the opening, as might be seen in allergic reactions or angioedema?", "Does the opening appear dry or cracked, which could be a sign of dehydration or cheilitis?", "Is there redness or inflammation at the opening, possibly due to stomatitis or gingivitis?", "Can you see lesions or ulcers at the opening, as might occur in aphthous stomatitis or herpes simplex infection?", "Does the opening appear stiff, which could be related to systemic sclerosis or fibrosis?", "Is there any indication that movement of the opening is painful, as might be seen in temporomandibular joint dysfunction or trauma?", "Can you identify abnormal tissue growth at the opening, such as a neoplasm or papilloma?", "Does the opening appear more flexible, possibly as a result of physical therapy or muscle relaxation?", "Is there a loss of elasticity at the opening, which could be due to aging or chronic inflammation?", "Does the opening appear larger, potentially due to stress, exertion, or emotional expression?", "Is there evidence of a smaller opening, possibly resulting from lacerations, burns, or surgical scarring?", "Can you observe changes in the opening that might be due to medication effects, such as increased swelling or dryness?", "Does the opening show signs of increased moisture or dryness, which could be related to salivary gland disorders or medication side effects?"], "properties": ["Is there a structure in the image where the angle between two parts measures between 35 and 55 degrees?", "Can you identify an area where the vertical distance between two opposing surfaces is approximately 40 to 50 millimeters?", "Does the image show an opening with a width of about 45 to 55 millimeters?", "Is there a visible gap measuring between 35 and 55 millimeters in height?", "Can you see an exposed cavity with an area of roughly 15 to 25 square centimeters?", "Is there an opening that appears oval or elliptical in shape?", "Does the image reveal a surface with a pink or reddish-pink coloration?", "Can you observe a region with a smooth and moist texture inside a cavity?", "Is there an area likely to have an internal temperature between 36.5 and 37.5 degrees Celsius?", "Does the image suggest a passage that could allow 200 to 500 milliliters of air per breath?"], "relational": ["Does the image show anatomical structures such as the teeth, tongue, or uvula that are typically visible when the oral cavity is exposed?", "Can you identify regions like the oral vestibule or the floor of the mouth in the image?", "Is there evidence of the mandible and maxilla being separated, suggesting movement at the temporomandibular joint?", "Does the image display features that could be attributed to the action of muscles such as the digastric or lateral pterygoid?", "Can you observe the oral cavity bordered by the lips, cheeks, and palates?", "Is there a visible pathway providing access to both the digestive and respiratory systems?", "Does the image reveal the lining of the oral cavity, such as oral mucosa or stratified squamous epithelium?", "Can you see anatomical spaces like the oropharynx or nasopharynx through the anterior opening?", "Is there a structure serving as an entryway to the pharynx, allowing for the passage of air or food?"], "contexual_behavior": ["Is there an individual whose posture suggests increased airflow to the lungs, such as during heavy exercise or airway obstruction?", "Does the image show a person who might experience reduced effectiveness in speech production due to altered lip and jaw positioning?", "Can you observe signs that suggest enhanced evaporative cooling, such as during physical exertion?", "Is there evidence that inhaled particles could bypass nasal filtration, increasing exposure to airborne contaminants?", "Does the image depict a scenario where rapid intake of food or fluids is facilitated?", "Can you identify a situation where the risk of pathogen entry is elevated due to bypassing nasal defenses?", "Is there a visual indication that inspired air may be less humidified compared to nasal breathing?", "Does the scene suggest decreased oral cavity moisture, possibly due to increased evaporation?", "Can you see features that might contribute to snoring, such as airway collapse or vibration of soft tissues during sleep?", "Is there evidence that the efficiency of chewing or swallowing could be reduced by disrupted jaw or lip alignment?", "Does the image suggest impaired maintenance of oral pressure necessary for effective bolus transport during swallowing?", "Can you observe a person who appears to be in respiratory distress, possibly attempting to maximize airflow?", "Is there a scenario where the sense of taste might be diminished due to altered airflow patterns?", "Does the context indicate facilitation of emergency airway access, such as for intubation or suctioning?", "Can you identify signs of involuntary or impaired oral movements that could be associated with neurological disorders affecting motor control?"], "functions": ["Is there an individual in the image whose airway appears more accessible for breathing or medical procedures?", "Can you observe a person whose oral cavity is positioned to allow direct airflow into the oropharynx?", "Does the image show someone whose facial expression would facilitate clear speech production or articulation?", "Is there a subject whose oral cavity is open in a way that would permit the entry of food or liquids for ingestion?", "Can you see a person whose mouth position would support mastication or the initiation of swallowing?", "Is there an individual whose oral cavity is accessible for visual inspection or dental examination?", "Does the image depict a scenario where airway management or obstruction removal could be performed through the oral route?", "Is there a person whose mouth position could enhance evaporative cooling or aid in thermoregulation?", "Can you identify a subject whose oral cavity is open, potentially altering saliva distribution or leading to oral dryness?", "Does the image show someone whose mouth is positioned to facilitate ventilation or expulsion during reflex actions such as yawning or coughing?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see cells with enlarged cytoplasm or modified organelle content?", "Can you identify areas where cells seem enlarged or shrunken, suggesting changes like hypertrophy or atrophy?", "Is there evidence of increased cell numbers in any region, which could indicate hyperplasia?"], "relational": ["Are there features in the image that suggest adaptation occurring at the molecular, cellular, tissue, or organ level?", "Is there interaction between cells and extracellular structures like the extracellular matrix, basement membrane, or collagen fibers?", "Can you see anatomical features such as blood vessels, alveoli, or renal tubules that could display signs of adaptation?"], "contexual_behavior": [], "functions": ["Does the image display signs of protective responses such as hypertrophy, atrophy, or autophagy to minimize cellular injury?", "Is there evidence that cells are surviving in adverse conditions, potentially contributing to chronic disease or malignancy?", "Can you identify features associated with cellular aging, such as senescence or altered repair capacity?"]}}, "lesion": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an area in the image that varies in size from a few millimeters to several centimeters?", "Can you identify a region with a round, oval, irregular, or linear shape?", "Does the image show any area with colors such as red, brown, black, white, or skin-colored?", "Is there a structure with a smooth, rough, scaly, or verrucous texture visible?", "Can you see a region with well-defined or ill-defined borders?", "Is there an area that appears superficial, partial-thickness, or full-thickness in depth?", "Does the image contain a region that looks soft, firm, hard, or fluctuant?", "Can you identify a surface that is flat, raised, depressed, or ulcerated?", "Is there a region whose volume appears variable based on its size and depth?", "Does any area seem to have increased temperature, possibly indicating inflammation or infection?", "Can you see a region that appears dry, moist, or exudative?", "Is there a structure that looks soft or hard, suggesting differences in firmness?", "Can you identify an area where the tissue appears to have decreased, normal, or increased elasticity?", "Does the image show a region that could be composed of cells, fluid, necrotic tissue, or fibrous material?", "Is there an area with low, intermediate, or high density as might be seen on imaging or by palpation?", "Can you see a region with uniform, variegated, or absent pigmentation patterns?", "Is there a surface that appears non-ulcerated or ulcerated?", "Does any area show signs of low, moderate, or high vascularity, such as increased redness or bleeding tendency?", "Can you identify a region with absent, scant, moderate, or copious exudate?", "Is there an area that appears to be growing slowly, moderately, or rapidly compared to surrounding tissue?"], "relational": ["Is there an area within the image where the structure of epithelial, connective, muscle, or nervous tissue appears altered?", "Can you identify a region in the skin, liver, brain, lung, or kidney that looks abnormal compared to the surrounding tissue?", "Does the image show any abnormality in regions such as the oral cavity, gastrointestinal tract, central nervous system, or skin?", "Is there a localized area that is surrounded by parenchyma, stroma, blood vessels, or a basement membrane?", "Can you see a region containing cells that resemble inflammatory, neoplastic, fibroblastic, or necrotic cell types?", "Does the image reveal a disruption in the structure or function of the nervous, respiratory, digestive, or integumentary system?", "Is there evidence of tissue disruption, infiltration, or inflammation in any part of the image?", "Can you identify a region with distinct margins, a capsule, or a clear interface with normal tissue?", "Does the image contain a structure that could be related to a tumor, ulcer, scar, or abscess?", "Is there an area involving specific tissue layers such as the epidermis, dermis, submucosa, muscularis, or subcutaneous tissue?"], "contexual_behavior": ["Is there a structure in the image that might heal more slowly if immune function is impaired?", "Can you identify an area that could increase in size during chronic inflammation?", "Does the image show a region where normal tissue regeneration might fail if fibrosis predominates?", "Is there a feature that could exhibit reduced repair activity in the context of diabetes mellitus?", "Can you see an area that might be more prone to infection in an immunocompromised state?", "Does the image contain a region that could demonstrate accelerated healing after therapeutic intervention?", "Is there a structure that might show impaired vascularization in a hypoxic environment?", "Can you identify an area that could persist due to ongoing exposure to toxins?", "Does the image show a region where increased scarring might occur during abnormal wound healing?", "Is there a feature that could fail to resolve in the presence of autoimmune disease?", "Can you see an area that might become more active following acute trauma?", "Does the image contain a region that could demonstrate decreased cellular turnover in aging tissue?", "Is there a structure that might exhibit delayed closure under malnutrition?", "Can you identify an area that could show increased inflammatory response during infection?", "Does the image show a region that might fail to repair due to poor blood supply?"], "functions": ["Does the image show an area of abnormal tissue change or damage?", "Is there a region where normal tissue architecture appears disrupted?", "Can you identify a structure that might impair the function of the surrounding tissue?", "Is there evidence of altered cell proliferation or increased cell death in a specific area?", "Does the image reveal signs of local inflammation, such as immune cell infiltration?", "Can you see a region that could be activating local immune responses?", "Is there an area where tissue repair or regeneration might be occurring, such as the presence of healing cells?", "Does the image show features suggesting the release of cytokines or growth factors in a localized region?", "Is there a visible abnormality that could compromise the function of an organ or tissue?", "Can you identify a region that might be contributing to chronic inflammation or disease progression?", "Is there evidence of vascular or lymphatic obstruction, such as localized swelling or impaired drainage?", "Does the image show an area that could be causing pain or altered sensation by affecting nerve endings?", "Can you see signs of protective responses like clot formation or increased immune activity in a specific region?"]}, "no_questions": {"contexual_properties": ["Does the image show a region with color changes that might be explained by vascular changes, hemorrhage, or pigment deposition?", "Is there an area with increased cellularity, indicating active proliferation of neoplastic or inflammatory cells?", "Can you identify an area that seems to have decreased in size, suggesting a response to treatment, immune clearance, or tissue resolution?"], "properties": ["Do you see a region that might have an elevated temperature, possibly due to inflammation or infection?", "Is there a structure with borders that are either sharply defined or poorly demarcated?", "Is there an area that appears densely cellular, suggesting high cellular proliferation?"], "relational": ["Does the image reveal a structure that could impact the nervous, respiratory, digestive, or musculoskeletal systems?", "Is there an abnormal area present within epithelial, connective, or muscle tissue?", "Can you identify a region in the image affecting organs such as the liver, lungs, kidneys, brain, or skin?"], "contexual_behavior": ["Is there an area where disrupted or occluded vascular supply could be decreasing nutrient delivery to surrounding tissues?", "Can you identify a region where local blood flow might be disrupted due to extensive vascular damage or compression, especially under hypoxic conditions?", "Does the image suggest impaired functional recovery after surgical intervention, possibly due to insufficient regenerative processes in a large area of tissue loss?"], "functions": ["Does the image contain an area where tissue regeneration or repair might be hindered, such as by destruction of progenitor cells?", "Is there evidence of a region that might be promoting or inhibiting inflammation, such as by releasing damage-associated molecular patterns or showing signs of tissue necrosis?", "Can you identify an area where nutrient or oxygen delivery could be compromised due to increased diffusion distances or damaged blood vessels?"]}}, "head tilted": {"yes_questions": {"contexual_properties": ["Is there an individual whose posture suggests an increased angle that could be related to neuromuscular or vestibular dysfunction?", "Can you identify a person displaying a posture commonly seen in conditions like torticollis or dystonia?", "Does the image show a posture that might become less pronounced after interventions such as muscle relaxants or rehabilitation?", "Is there evidence of a change in the direction of a postural abnormality that could be explained by neurological conditions or brainstem involvement?", "Can you observe signs of muscle weakness, as might be seen in myasthenia gravis or following peripheral nerve injury?", "Does the individual appear to have neck stiffness, which could be associated with disorders like meningitis or cervical dystonia?", "Is there any indication of trauma to the cervical spine, head, or neck muscles that could explain the observed posture?", "Can you see a posture that might resolve spontaneously, as in benign paroxysmal torticollis or transient vestibular dysfunction?", "Does the abnormal posture seem more pronounced, possibly due to fatigue, as seen in neuromuscular diseases?", "Is there visual evidence that physical therapy targeting muscle balance and postural control could be beneficial for the observed posture?", "Does the posture appear fixed, suggesting chronic conditions such as cervical dystonia or musculoskeletal contracture?", "Is there any indication that the degree of the abnormal posture fluctuates, possibly due to diurnal variation or medication effects?", "Can you observe signs of abnormal muscle tone, such as spasticity, which might be present in cerebral palsy or dystonia?", "Does the severity of the postural abnormality appear to increase in the context of psychological or physical stress?", "Is there a visible change in the abnormal posture with alterations in body position, such as between lying down and standing, possibly reflecting vestibular or proprioceptive influences?"], "properties": ["Does the image show an individual whose head forms an angle between 15 and 45 degrees from the vertical axis?", "Can you identify a posture where the cervical spine displays lateral curvature without significant rotation?", "Is there a visible change in the distance between the ear and shoulder, measuring approximately 2 to 5 centimeters on one side?", "Does the image depict a person with facial features that appear asymmetrical, with one side lower than the other relative to the horizontal plane?", "Can you observe a shift in head weight distribution toward one side, potentially increasing the load on neck muscles on that side?", "Is there evidence of increased muscle tension in the sternocleidomastoid on the same side as the tilt and in the upper trapezius on the opposite side?", "Does the neck in the image show a lateral flexion angle up to 45 degrees from the midline?", "Is the duration of the depicted head position consistent with a posture held for several seconds to minutes?", "Can you see a neck angle between 15 and 45 degrees of lateral flexion in the posture shown?"], "relational": ["Does the image show a position where the cervical region or neck is visibly engaged?", "Can you identify muscles such as the sternocleidomastoid or scalene muscles appearing active or elongated?", "Is there evidence of the occipital bone or upper cervical vertebrae supporting a shifted head position?", "Does the alignment of the vertebrae suggest movement at the atlanto-occipital joint?", "Can you observe anatomical features indicating tension or stretch in the neck muscles or ligaments?", "Is there a visible change in the relationship between the skull base and the cervical spine?", "Does the image suggest involvement of the accessory nerve or cervical spinal nerves in controlling the head's posture?", "Are there signs that the atlas (C1) or axis (C2) are engaged in supporting the head's orientation?", "Can you see any indication of altered muscle length or ligament tension in the neck area?", "Is there visual evidence of tissues such as cervical ligaments or intervertebral discs being stretched or compressed?"], "contexual_behavior": ["Is there an individual whose posture could lead to asymmetric vestibular input and potentially impair balance?", "Can you identify a person whose head position might alter the orientation of the semicircular canals and otolith organs relative to gravity?", "Does the image show someone at increased risk of dizziness, especially if they have a vestibular disorder such as benign paroxysmal positional vertigo?", "Is there a subject whose visual field alignment may be reduced due to misalignment of the eyes with the horizontal and vertical axes?", "Can you see a person whose swallowing efficiency might be affected by changes in the trajectory of the bolus and pharyngeal muscle coordination?", "Does the posture of anyone in the image appear likely to provoke abnormal vestibular responses and worsen vertigo symptoms in those with vestibular disorders?", "Is there an individual whose airway patency during sleep could be improved by repositioning of the tongue and soft tissues?", "Can you identify a person whose neck muscles may be more relaxed due to a supported and comfortable cervical spine position?", "Does the image show someone whose posture could stimulate abnormal endolymph movement and trigger nystagmus in the presence of inner ear dysfunction?", "Is there a subject whose head position might affect vertebral artery patency and alter cerebral blood flow, especially if the position is extreme?", "Can you see a person whose coordination during walking could be impaired by disruption of vestibulo-ocular and vestibulospinal reflexes?", "Is there an individual whose posture could facilitate sinus drainage by using gravity to enhance mucus clearance?", "Does the image include someone whose auditory function might be reduced due to altered eustachian tube drainage and increased middle ear pressure?", "Is there a person whose cervical spine appears to be under increased strain from uneven loading or muscle fatigue due to their posture?", "Can you identify an individual whose head position might facilitate communication in social interactions by compensating for gaze or facial asymmetry, particularly in the context of neurological impairment?"], "functions": ["Does the image show a posture that could alter visual and vestibular input, potentially impacting motor coordination?", "Is there an individual whose head position might influence balance or spatial orientation by changing the alignment of the vestibular apparatus?", "Can you identify a posture that could be used to optimize binocular vision or adjust the visual field?", "Does the image depict a position that would modify vestibular input by altering the orientation of the semicircular canals or otolith organs?", "Is there visible activation of neck muscles that would be required to maintain a non-neutral head position against gravity?", "Can you see a posture that might serve as a compensatory strategy in the context of neurological disorders to improve gaze or balance?", "Is there evidence of a position that could facilitate gaze stabilization through the vestibulo-ocular reflex or help maintain visual fixation?", "Does the head position in the image appear likely to affect swallowing mechanics or airway patency?", "Can you identify a posture that might be used to compensate for sensory deficits by optimizing remaining sensory input?", "Is there a head position that would alter proprioceptive feedback from the cervical spine, potentially influencing postural control or movement perception?"]}, "no_questions": {"contexual_properties": ["Does the image suggest increased tenderness or nerve irritation in the tissue overlying a bone injury, as might be inferred from signs of inflammation?", "Can you see evidence of depressed or comminuted fractures of the exposed bone after the soft tissue has been retracted?", "Is there visible evidence of increased bleeding or vascular injury in the soft tissue overlying a cranial fracture?"], "properties": ["Can you visually estimate if the thickness of the exposed cranial bones falls within the range of 4 to 7 millimeters?", "Does the density of the visible cranial bone appear consistent with a value of approximately 1.5 to 2.0 grams per cubic centimeter?", "Is the length of the largest visible fracture several centimeters or possibly up to 10 centimeters or more?"], "relational": ["Does the image show anatomical boundaries such as the superior nuchal line, supraorbital margin, temporal lines, or zygomatic arches?", "Is there evidence that the protective barrier normally provided by the scalp is absent, exposing the underlying cranial bones?", "Does the image reveal the outer table of the skull?"], "contexual_behavior": ["Does the image indicate delayed healing or increased tissue damage that could slow the recovery process?", "Can you observe compromised structural support for facial muscles due to destabilized bone and connective tissue?", "Does the image suggest impaired hemostatic function, such as visible bleeding from disrupted blood vessels?"], "functions": ["Does the image allow for assessment of the extent of bone injury and involvement of vital structures to inform treatment planning?", "Is there visual access to injured vessels that would facilitate bleeding control or hemostasis?", "Is there an opportunity to assess the displacement or alignment of bone fragments for surgical repair?"]}}, "bilateral cleft palate": {"yes_questions": {"contexual_properties": ["Does the image show a palatal gap that appears wider than usual, possibly indicating a pre-surgical or growing state?", "Can you observe a deepened separation in the palate that might result from vertical growth of the maxilla during childhood?", "Is there evidence of significant tissue deficiency in the palatal region, suggesting a preoperative or delayed repair condition?", "Do you see abnormal tissue characteristics, such as irregular surfaces, that could be associated with chronic inflammation or infection?", "Is there a palatal defect that appears more pronounced, possibly reflecting a period of rapid craniofacial growth without surgical intervention?", "Can you identify areas of redness or purplish discoloration in the palate, which may indicate infection or inflammation?", "Is there visible scar tissue in the palatal region, suggesting previous surgical repair?", "Do you notice swelling in the palate that could be due to recent surgery or acute infection?", "Is the palatal gap visibly reduced, possibly indicating a successful surgical intervention?", "Can you detect the presence of fluid or exudate in the palatal area, which might be due to infection, inflammation, or fistula formation?", "Are there any ulcerations or open sores in the palate that could result from trauma, infection, or poor oral hygiene?", "Do you see abnormal mucosal texture, such as roughness or irregularity, possibly due to repeated infections, scarring, or failed repairs?", "Is the palatal separation less apparent, potentially reflecting tissue remodeling after surgical repair and aging?", "Can you observe signs of bleeding in the palatal region, which may occur during surgery, trauma, or acute infection?", "Is there a visible fistula or abnormal opening in the palate, possibly indicating a postoperative complication or incomplete healing?"], "properties": ["Is there a structure in the image that shows a gap measuring between 5 and 20 millimeters in width?", "Can you identify a separation extending from the incisive foramen to the uvula, with a length of approximately 20 to 40 millimeters?", "Does the image display a shallow to moderate depression, with a depth between 2 and 8 millimeters, in the palatal region?", "Is there a visible V-shaped or U-shaped gap along the midline of the palate?", "Can you see a midline defect affecting both the hard and soft palate symmetrically?", "Does the image show a structure with a frequency of occurrence in live births between 0.02 and 0.05 percent?", "Is there tissue present that appears pink to reddish, possibly with areas of erythema, in the palatal region?", "Can you identify disrupted mucosa, connective tissue, or exposed bone or cartilage within a palatal gap?", "Does the image reveal a complete separation between the palatal shelves, with no fusion at the midline?", "Is there an area where the palatal tissue thickness is reduced to less than 2 millimeters?", "Can you observe an irregular or uneven surface texture, possibly with ulcerations or granulation tissue, in the palate?", "Is there evidence of bony defects in the palatal region, given that such defects are present in more than 90 percent of similar cases?", "Does the image show involvement of both the hard and soft palate, with the hard palate nearly always affected and the soft palate in most cases?", "Can you see discontinuity or compromised integrity of the mucosa, with exposure of underlying structures in the palate?", "Is the distance between two cleft margins in the palatal region within the range of 5 to 20 millimeters?"], "relational": ["Does the image show a disruption involving both the hard and soft regions forming the roof of the oral cavity?", "Can you identify a gap or separation affecting the midline and lateral aspects of the palatal shelves?", "Is there evidence of interrupted continuity in the maxilla or palatine bones within the oral cavity?", "Does the image reveal separation of the mucosal, muscular, and bony layers of the palate?", "Can you observe a defect indicating failure of fusion between the palatal processes of the maxilla?", "Is there a visible abnormality that could impact muscles such as the levator veli palatini or tensor veli palatini?", "Does the image show a structure adjacent to the nasal septum, upper lip, or lateral nasal wall that appears disrupted?", "Are the anatomical boundaries from the alveolar ridge to the uvula and lateral palatal shelves visibly altered?", "Can you detect additional anomalies such as a cleft in the upper lip, irregular dental development, or nasal deformities?", "Is there an abnormal opening between the oral and nasal cavities that could affect speech or feeding?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structural defect that could allow food or liquids to pass from the mouth into the nasal cavity, potentially leading to nasal regurgitation?", "Is there a visible abnormal communication between the oral and nasal spaces that might disrupt normal swallowing or oropharyngeal coordination?", "Can you identify a feature that could prevent proper closure of the velopharyngeal port, possibly resulting in hypernasal speech or articulation difficulties?", "Does the image suggest a condition that would make it difficult for an infant to create suction during feeding, potentially leading to poor intake or prolonged feeding times?", "Is there a structural abnormality that could compromise airway protection during eating or drinking, increasing the risk of aspiration or choking?", "Can you see an oronasal fistula or palatal defect that disrupts the normal separation between the oral and nasal cavities?", "Does the image show a feature that might alter nasal airflow or increase the likelihood of airway obstruction, possibly causing breathing difficulties?", "Is there evidence of a defect that could reduce the ability to generate intraoral pressure, affecting effective sucking, swallowing, or speech sound production?", "Can you identify a structural issue that might impair Eustachian tube function, increasing the risk of recurrent ear infections or middle ear effusion?", "Does the image suggest disturbances in facial growth or dental alignment, such as maxillary deficiency or malocclusion?", "Is there any indication that the individual may have developed compensatory mechanisms, such as atypical speech articulation or altered swallowing patterns, to adapt to a structural defect in the palate?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an object that could contain iron at a concentration of 0.5 to 1.5 milligrams per gram of tissue?", "Is there a structure in the image that measures between 11 and 14 centimeters in length?", "Does the image show an ovoid or wedge-shaped anatomical structure?"], "relational": ["Can you see a structure supported by the splenorenal or gastrosplenic ligament?", "Does the image show an organ that interacts with lymph nodes, bone marrow, or thymus in immune responses?", "Can you identify a secondary lymphoid organ within the lymphatic system?"], "contexual_behavior": [], "functions": ["Can you identify a region involved in breaking down senescent red blood cells and recycling iron to the bone marrow?", "Is there evidence of phagocytic activity by macrophages in a particular region of the tissue?", "Does the image show an organ that regulates the balance of white blood cells and platelets by sequestering and releasing them as needed?"]}}, "vagina": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a length between 7 and 10 centimeters?", "Is there an anatomical feature with a relaxed diameter of approximately 2.5 to 3.5 centimeters?", "Can you identify a mucosal surface that appears pale pink in color?", "Does the image contain a wall that looks highly elastic or capable of significant distension?", "Is there evidence of a moist environment maintained by mucosal secretions?", "Can you see a lining that might be composed of stratified squamous epithelial cells?", "Is there a structure whose wall appears soft and rugose due to the presence of folds?", "Does the image show a tissue with moderate to high vascular density?", "Is there a structure likely to have substantial collagen content, contributing to strength and elasticity?", "Can you identify an area that may contain 8 to 12 prominent mucosal folds?", "Is there a region where the thickness of the epithelial lining could be about 200 to 300 micrometers?", "Does the image suggest the presence of a mucous membrane with low lipid content?", "Is there a structure that could support a microbial community dominated by Lactobacillus species?", "Can you see an area where the nerve ending density might be moderate, with higher concentrations near an opening?", "Is there a feature that could maintain a temperature close to 37 degrees Celsius?", "Does the image show a tissue likely to have high glycogen content in its epithelium?", "Can you identify a region where secretions might have a water content of 90 to 95 percent?", "Is there evidence of a structure that produces 1 to 4 milliliters of secretions per day?", "Does the image suggest a mucosal surface with a normal lactic acid concentration of about 1 to 2 percent?"], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify a region that is anatomically connected to the cervix at its upper end and the vulva at its lower end?", "Is there a structure located within the pelvic region of the body?", "Does the image contain an area situated between the bladder anteriorly and the rectum posteriorly?", "Can you see a structure composed of stratified squamous epithelium, smooth muscle, and connective tissue?", "Is there a region whose upper boundary is formed by the cervix and which continues into the uterus?", "Does the image include an external opening that serves as the entrance to an internal canal, corresponding to the vulva or vaginal orifice?", "Can you identify a wall composed of mucosal, muscular, and adventitial layers?", "Is there a structure that receives blood supply from the vaginal artery or branches of the uterine artery?", "Does the image show an area with lymphatic drainage to the internal iliac, external iliac, or superficial inguinal lymph nodes?", "Can you see a region innervated by the pudendal nerve, pelvic splanchnic nerves, or uterovaginal plexus?", "Is there a structure separated from the urinary system by a septum and lying posterior to the bladder and urethra?", "Does the image include a region separated from the rectum by a septum and lying anterior to the rectum?", "Can you identify a structure contained within the pelvic cavity?"], "contexual_behavior": ["Is there evidence of a structure that increases lubrication in response to sexual arousal?", "Can you identify a region that might show reduced immune defense during menstruation?", "Does the image display features consistent with impaired self-cleaning, as might be seen in postmenopausal individuals?", "Is there a structure where pH changes could occur during bacterial infection, potentially becoming less acidic?", "Can you observe any indication of decreased elasticity that could result from tissue remodeling after childbirth?", "Is there a region that might exhibit increased mucosal immune activity during infection, such as immune cell recruitment?", "Does the image suggest reduced lubrication that could be associated with decreased estrogen levels during menopause?", "Can you see signs of weakened barrier function that might result from disruption of the normal microbial flora, such as after antibiotic use?", "Is there evidence of enhanced protective flora, possibly favoring Lactobacillus dominance, as might occur during pregnancy?", "Can you identify features suggesting slowed epithelial repair or regeneration, which could be related to aging?", "Does the image show increased susceptibility to irritation that might follow disruption of the mucosal barrier, such as after douching?", "Is there a region that could have decreased resistance to sexually transmitted infections due to compromised mucosal immunity or altered microbiome?", "Can you observe changes in secretory activity, such as increased cervical mucus production and altered consistency, that might occur during ovulation?", "Is there evidence of altered healing capacity or tissue repair following trauma, potentially influenced by hormonal status?", "Does the image suggest a shift in microbial balance or flora composition that could result from hormonal therapy?"], "functions": ["Does the image show a structure that serves as a canal for childbirth or menstrual flow?", "Is there an anatomical feature that connects the external genitalia to the uterus within the female reproductive system?", "Can you identify a passageway that enables the exit of menstrual blood from the uterus?", "Does the image contain a moist, muscular canal that could guide sperm toward the cervix?", "Is there a structure that facilitates the deposition of sperm during sexual intercourse?", "Can you see an area that acts as a birth canal during parturition?", "Does the image show a region that might maintain an acidic environment due to lactic acid production?", "Is there evidence of a mucosal barrier or secretions that could contribute to self-cleaning and microbial balance?", "Can you identify a structure that could host immune cells or produce antimicrobial peptides as part of immune defense?", "Is there a feature that serves as both an entry and exit point for reproductive processes in the female reproductive tract?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image suggest invasion into the chest wall, diaphragm, or mediastinum?", "Can you see a structure arising from the membrane that lines the lungs?", "Are there abnormalities in mediastinal, hilar, or diaphragmatic lymph nodes that could indicate disease spread?"], "contexual_behavior": [], "functions": ["Are there signs of chronic inflammation or altered immune responses in the pleural region?", "Can you identify signs of respiratory distress or restricted lung movement in the image?", "Does the image show a lung that appears encased or has reduced expansion due to surrounding tissue?"]}}, "mouth": {"yes_questions": {"contexual_properties": ["Is there a structure that appears dry, which could indicate dehydration or a side effect of medication?", "Can you identify any ulcers that might suggest infection, autoimmune disease, trauma, or chemotherapy effects?", "Does the image show a change in color, such as bluish, yellowish, or pale tones, which could be related to cyanosis, jaundice, anemia, or recent food or medication intake?", "Is there evidence of swelling that could be due to an allergic reaction, infection, or inflammation?", "Can you see signs of excess saliva, possibly associated with nausea, gastroesophageal reflux, medication, or toxin exposure?", "Is there visible inflammation that might indicate gingivitis, stomatitis, or oral lichen planus?", "Are there white patches present, which could be due to oral candidiasis, leukoplakia, or lichen planus?", "Does the lining appear thickened, possibly as a result of chronic irritation, leukoplakia, or tobacco use?", "Can you identify any sores that might be caused by viral infection, trauma, or aphthous stomatitis?", "Is there increased redness that could suggest inflammation, infection, or vitamin deficiency?", "Are there lesions visible that may be consistent with herpes simplex, syphilis, or oral cancer?", "Do you observe any cracking that could be related to dehydration, cheilitis, or vitamin B deficiency?", "Is the lining thinner than usual, which might indicate atrophic glossitis, lichen planus, or aging?", "Are there abnormal growths such as papillomas, fibromas, or other neoplasms present?", "Does the structure appear more sensitive, possibly due to allergic reaction, mucositis, or exposure to irritants?", "Can you see blisters that could be associated with herpes simplex infection, pemphigus vulgaris, or hand-foot-and-mouth disease?", "Is there evidence of increased bacterial presence, such as signs of poor oral hygiene, periodontal disease, or xerostomia?", "Are there any clues suggesting a metallic taste, such as medication use, chemotherapy, or heavy metal exposure?", "Does the structure appear painful, possibly due to infection, ulceration, trauma, or recent dental procedures?", "Can you observe pigmentation changes that might be related to Addison's disease, Peutz-Jeghers syndrome, or medication effects?"], "properties": ["Does the image show an opening bordered by lips with an elliptical or oval shape?", "Can you identify a structure with a width of approximately 7 to 8 centimeters and a height of 2 to 3 centimeters in adults?", "Is there a region where the mucosal surface appears pink, suggesting underlying vascularization?", "Can you see an area with a smooth and moist texture lining the inside of an opening?", "Does the image contain a structure that could contain 32 mineralized elements primarily composed of hydroxyapatite?", "Is there evidence of tissue with a thickness ranging from 0.5 to 2 millimeters?", "Can you identify a space that might produce about 1 to 1.5 liters of fluid daily?", "Does the image show a cavity that could contain both soft tissues with a density around 1.04 grams per cubic centimeter and hard mineralized structures?", "Is there a region likely to contain stratified squamous epithelial cells, mucous cells, and taste receptor cells?", "Can you see an area that could harbor microbial species such as Streptococcus, Actinomyces, Veillonella, or Candida?", "Is there a structure whose opening measures about 5 to 6 centimeters in width and 2 to 3 centimeters in height?", "Does the image include a space extending approximately 5 to 6 centimeters from the lips to the oropharynx?"], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify a region that is adjacent to the nasal cavity, cheeks, or chin?", "Is there an area bounded by the lips, cheeks, palate, and the floor of the mouth?", "Does the image contain organs such as the tongue or teeth?", "Can you see a lining that could be composed of stratified squamous epithelium?", "Is there evidence of minor salivary glands or openings of major salivary glands such as the parotid, submandibular, or sublingual glands?", "Does the structure shown have a posterior continuity with the pharynx, serving as its anterior opening?", "Are there supporting bones such as the maxilla or mandible visible in the image?", "Can you identify muscles like the orbicularis oris or buccinator associated with the region?", "Does the image display teeth types such as incisors, canines, premolars, or molars?", "Is there a separation between the oral space and the nasal cavity by the hard or soft palate?", "Can you see anatomical features that suggest innervation by the trigeminal, facial, or glossopharyngeal nerves?", "Is there evidence of blood supply from branches of the maxillary, facial, or lingual arteries?", "Does the image contain an anatomical space bounded by the teeth and gums, corresponding to the oral cavity?"], "contexual_behavior": ["Does the image show a structure where saliva production might be reduced due to dehydration?", "Is there evidence of impaired initial digestion that could be linked to insufficient saliva, as seen in xerostomia?", "Can you identify a region where defense against pathogens may be compromised, such as during immunosuppression?", "Does the image suggest increased saliva secretion in response to sour foods?", "Is there visible accumulation of plaque or debris that could indicate poor cleansing function due to inadequate oral hygiene?", "Can you observe signs of a weakened mucosal barrier, possibly resulting from chemotherapy-induced cell damage?", "Is there any indication of altered taste perception that might occur during upper respiratory infections?", "Does the structure show delayed wound healing, as might be seen in diabetes with impaired regeneration?", "Is there evidence of reduced buffering capacity, such as might result from chronic acid reflux overwhelming neutralizing mechanisms?", "Can you see features that suggest increased antimicrobial activity, such as during an oral infection?", "Is there any indication of impaired speech function that could be due to disrupted motor control after neurological injury?", "Does the image show reduced mechanical breakdown of food, possibly associated with tooth loss and decreased mastication?", "Are there signs of enhanced protective mechanisms against toxins, such as increased saliva or mucosal defense?", "Can you observe decreased enzymatic activity that might occur during prolonged fasting due to reduced salivary enzyme secretion?", "Is there evidence of slowed mucosal regeneration, as might be seen in vitamin deficiencies affecting cell repair?"], "functions": ["Does the image show a structure involved in food intake or the initiation of digestion?", "Can you identify an area where mechanical breakdown of food occurs through chewing?", "Is there evidence of teeth and tongue working together to process food?", "Does the image display a region where saliva is produced or secreted?", "Can you see features associated with the presence of digestive enzymes like amylase?", "Is there a structure that enables the detection of taste through taste buds?", "Does the image include components responsible for gustatory perception?", "Can you identify anatomical parts that contribute to speech articulation, such as lips, tongue, teeth, or palate?", "Is there a region where a bolus could be formed and moved toward the pharynx for swallowing?", "Does the image show evidence of mechanisms protecting against pathogens, such as saliva or oral mucosa?", "Can you observe features that help regulate pH, moisture, or microbial balance in the oral cavity?", "Is there a visible indication of major or minor salivary glands aiding in lubrication and oral health?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display a vessel adjacent to the esophagus or vertebral column?", "Does the image show a structure that is part of the cardiovascular system?", "Can you identify two major parallel vessels responsible for arterial outflow and venous return?"], "contexual_behavior": [], "functions": ["Does the image contain a vessel that regulates blood flow to organs by distributing blood through branching arteries?", "Can you see a structure that receives blood during ventricular systole and releases it steadily during diastole?", "Does the image contain a structure that facilitates nutrient and oxygen delivery to peripheral tissues through its arterial branches?"]}}, "defect": {"yes_questions": {"contexual_properties": ["Is there an area in the image that appears to have increased in size, possibly due to ongoing tissue damage or inflammation?", "Can you identify a region that seems to be decreasing in size, suggesting effective healing or tissue regeneration?", "Does the image show a structure whose shape appears altered, potentially from mechanical forces or uneven tissue remodeling?", "Is there a region that stands out more due to increased contrast with surrounding tissue, swelling, or surface changes?", "Can you see an area that has become less visible, possibly indicating healing, normalized pigmentation, or reduced swelling?", "Is there a region displaying a change in color that could be due to bleeding, infection, inflammation, or healing processes?", "Does the image reveal an area that appears deeper, which might result from tissue loss, necrosis, or erosion?", "Can you identify a region that has become shallower, possibly due to granulation tissue formation or superficial healing?", "Is there an area with irregular borders, suggesting uneven tissue destruction or pathological margin disruption?", "Does the image show a region with fluid accumulation, which could be due to inflammation, infection, or exudate formation?", "Can you see an area that appears filled with new tissue, such as granulation, fibrosis, or scar formation?", "Is there a region where the surface epithelium seems lost and underlying tissue is exposed, indicating possible ulceration?", "Does the image show signs of new tissue formation, reduced inflammation, or re-epithelialization in a particular area?", "Can you identify a region that appears infected, with possible signs of microorganism colonization or immune response?", "Is there an area where the texture has changed, potentially due to fibrosis, edema, necrosis, or tissue remodeling?", "Does the image show a region that appears hardened, which might be due to fibrosis, calcification, or chronic inflammation?", "Can you see an area that has become softer, possibly as a result of increased edema, necrosis, or liquefaction?", "Is there evidence of increased inflammation in a region, such as swelling or redness, possibly from acute injury or immune activation?", "Does the image reveal new tissue growth in a region, suggesting healing, granulation, or regeneration?", "Can you identify an area where the composition appears altered, with changes in cellular, fibrous, or fluid components due to disease or healing?"], "properties": ["Can you identify an area whose size could be measured in millimeters or centimeters?", "Is there a region with a shape that appears round, oval, linear, or irregular?", "Does the image show a zone with varying depth, from superficial to full-thickness tissue involvement?", "Can you see an area where surface area could be calculated by multiplying length and width?", "Is there a region displaying colors such as red, pink, yellow, or pale, possibly indicating tissue exposure or healing?", "Does the image contain a surface that appears smooth, granular, necrotic, or sloughy?", "Can you identify a region where volume could be determined by assessing length, width, and depth?", "Is there an area with well-defined or poorly defined borders, suggesting clarity or lack thereof at the margins?", "Can you see a region composed of exposed tissue, necrotic debris, fibrin, or granulation tissue?", "Is there an area where the firmness or cellularity of the tissue could be visually assessed?", "Does the image show a region that might have elevated temperature, suggesting local inflammation or infection?", "Can you identify an area where the local environment might be slightly acidic, as in chronic wounds?", "Is there a region that appears dry, moist, or exudative, indicating different moisture levels or presence of fluid?", "Does the image show an area whose duration or healing time could be inferred based on its appearance?", "Can you see a region located within skin, mucosa, or internal organs, indicating variable tissue involvement?", "Is there an area with edges that appear undermined, rolled, or flat, possibly reflecting chronicity or healing stage?", "Does the tissue within a region appear red, yellow, or black, suggesting granulation, slough, or necrosis?", "Can you identify an area with visible exudate, such as serous, purulent, or sanguineous fluid?", "Is there a region that appears soft or firm, potentially indicating acute or chronic tissue consistency?", "Can you see an area where the healing rate might be inferred from its size, depth, or appearance?"], "relational": ["Is there an area within an organ, tissue, bone, or vessel that appears structurally altered or disrupted?", "Can you identify a region in the nervous, cardiovascular, musculoskeletal, or digestive system that shows signs of abnormality?", "Does the image show any disruption involving epithelial, connective, muscle, or nervous tissue?", "Is there evidence of an abnormality present in the head, thorax, abdomen, or limbs?", "Can you see a region where the normal structure or function of an organ appears impaired?", "Does the image reveal the presence of cells such as fibroblasts, inflammatory cells, epithelial cells, or muscle cells at a site of disruption?", "Is there a visible abnormality that is part of a larger anatomical structure, such as an organ system or body region?", "Can you identify a localized abnormality that could correspond to a septal, neural tube, ventricular, or diaphragmatic subtype based on its anatomical location?", "Are there structures adjacent to an area of disruption, such as neighboring organs, surrounding tissues, blood vessels, or nerves?", "Does the image show margins of affected tissue or boundaries defined by adjacent normal structures or anatomical landmarks?"], "contexual_behavior": ["Is there evidence of tissue that fails to maintain normal function under stress, suggesting compromised structural integrity?", "Can you identify a region where physiological processes appear worsened, possibly indicating amplification of pathological mechanisms during disease progression?", "Does the image show an organ with reduced performance that could be related to exposure to environmental toxins or impaired protective barriers?", "Is there a visible area where metabolic activity seems decreased, which might occur during infection due to impaired energy production?", "Can you detect features that suggest disrupted cellular signaling, especially under low-oxygen conditions?", "Is there evidence of altered immune response or impaired cytokine production in regions affected by inflammation?", "Do you observe signs of increased susceptibility to functional failure, such as features associated with accelerated aging or reduced regenerative capacity?", "Are there indications of impaired repair mechanisms, such as poor cell proliferation or abnormal extracellular matrix remodeling after injury?", "Does the image reveal regions with reduced enzyme activity, possibly during metabolic stress?", "Can you identify abnormal physiological responses to exercise, such as impaired cardiovascular or muscular adaptation?", "Is there evidence of impaired detoxification, such as disrupted metabolic enzyme or transporter function in the presence of drugs?", "Do you see features that suggest accelerated tissue degeneration or impaired compensatory mechanisms in the context of chronic disease?", "Are there signs of impaired adaptation to fasting or starvation, such as reduced metabolic flexibility?", "Can you detect diminished hormone regulation, possibly due to disrupted hormone synthesis or receptor signaling during endocrine disorders?", "Is there evidence of altered organ function or impaired homeostatic regulation during acute illness?"], "functions": ["Does the image show any disruption or abnormality that could impair the normal function of a biological system?", "Is there evidence of interference with typical physiological processes, such as deviations from normal structure or function?", "Can you identify a region where tissue or organ function appears reduced, altered, or lost?", "Does the image suggest any disturbance in regulatory activities, such as impaired feedback mechanisms or control pathways?", "Is there any indication of abnormal cellular behavior, like uncontrolled proliferation or loss of differentiation?", "Can you see signs of disrupted metabolic pathways, such as blocked or misdirected biochemical reactions?", "Does the image contain features that might be associated with the initiation or progression of a pathological process?", "Is there evidence of instability or imbalance in the maintenance of internal conditions?", "Can you identify areas where signal transduction or cell communication may be impaired, leading to faulty coordination?", "Does the image reveal any loss of specific physiological capabilities or reduced efficiency in biological functions?"]}, "no_questions": {"contexual_properties": ["Can you see a structure that appears thinner, possibly as a result of aging or repeated trauma?", "Do you observe any creases that could be associated with aging or cardiovascular disease?", "Do you observe any changes in texture that might be related to scarring or chronic dermatological conditions?"], "properties": ["Can you see a structure with low tissue density due to high fat and low cartilage content?", "Does the image show a region with minimal or absent cartilage, distinguishing it from other parts of the external ear?", "Can you identify an area with a thickness of about 4 to 8 millimeters?"], "relational": ["Can you identify an area whose lymphatic drainage could be directed toward the superficial parotid or mastoid lymph nodes?", "Can you identify a fleshy region forming the lower portion of the external ear?", "Is there a part of the external ear where the skin includes layers such as the epidermis, dermis, and subcutaneous tissue?"], "contexual_behavior": ["Does the image include an area that may be more prone to bruising in bleeding disorders due to fragile capillaries?", "Is there a structure that could have a reduced vascular response in the presence of circulatory disorders?", "Does the image include a part that would increase blood flow for heat dissipation in high temperatures?"], "functions": ["Does the image show a soft tissue structure that provides support for external ornaments or devices?", "Can you see a structure that might allow for passive heat loss due to its blood supply?", "Can you identify an area that appears flexible and suitable for the attachment of earrings?"]}}, "cervix": {"yes_questions": {"contexual_properties": ["Is there a structure that appears enlarged, which could indicate pregnancy or inflammation?", "Can you identify an area that looks swollen, possibly due to infection or trauma?", "Does the image show a region with color changes that might be associated with pregnancy, ovulation, or infection?", "Is there a part that appears softer, suggesting physiological changes related to ovulation or late pregnancy?", "Can you see a structure that looks firmer, which may indicate a non-fertile or non-pregnant state?", "Is there evidence of shortening in a structure, as might occur during labor or cervical ripening?", "Does the image show a lengthened region that could be consistent with the postpartum or non-pregnant state?", "Is there an area that appears more vascular, possibly due to pregnancy or hormonal changes?", "Can you identify lesions that might result from infection, trauma, or neoplastic processes?", "Is there a region that looks friable, which could be due to inflammation, infection, or dysplasia?", "Does the image show thickening of tissue, potentially related to chronic inflammation, neoplastic growth, or hormonal stimulation?", "Is there a visibly thinned area, as might be seen during labor effacement?", "Can you detect increased mucus production, which could be associated with ovulation or pregnancy?", "Is there evidence of dilation in a structure, possibly due to labor or a medical procedure?", "Does the image show signs of effacement, as might occur in early labor?", "Can you identify abnormal tissue growth that could suggest dysplasia, cancer, or chronic inflammation?", "Is there evidence of cellular changes that might be linked to HPV infection, dysplasia, or malignancy?", "Does the image reveal ulceration, which could result from severe infection, malignancy, or trauma?", "Can you see polyp-like growths that may be due to benign mucosal overgrowth or chronic inflammation?", "Is there an area with increased discharge, possibly related to ovulation, pregnancy, or infection?"], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify an anatomical feature that is adjacent to both the vagina and the urinary bladder?", "Is there a structure that connects the uterus and the vagina?", "Does the image include a region related to the lower uterine segment or the uterine body?", "Can you see a structure composed of dense connective tissue, smooth muscle, or stratified squamous epithelium?", "Is there an object located at the lower part of the female reproductive tract?", "Does the image display a structure forming the superior boundary of the vagina or projecting into its upper portion?", "Can you identify a passageway between the uterine cavity and the vaginal canal?", "Is there a region that appears to receive blood supply from the uterine artery or the vaginal artery?", "Does the image show a structure with lymphatic drainage to parametrial, obturator, or internal iliac lymph nodes?"], "contexual_behavior": [], "functions": ["Is there a structure visible that allows menstrual flow from the uterus to the vagina?", "Can you identify an anatomical feature that facilitates the entry of sperm into the reproductive tract?", "Does the image show a barrier that helps prevent pathogens from reaching the uterus?", "Is there evidence of a canal that can open or close to regulate passage between the uterus and vagina?", "Can you see a region where muscular or hormonal control might alter the opening between two reproductive organs?", "Is there a structure that produces mucus acting as a physical and chemical barrier to microorganisms?", "Does the image include a feature that could alter mucus consistency to support sperm survival during ovulation?", "Can you identify an area that would dilate and efface to allow passage of the fetus during childbirth?", "Is there a region containing glands that secrete mucus in response to hormonal signals such as estrogen?", "Does the image show a structure that produces mucus to guide and nourish sperm toward the uterus?", "Can you observe any anatomical feature that changes position or firmness throughout the menstrual cycle?", "Is there evidence of a mucus plug that could seal the uterine cavity to prevent infection during pregnancy?", "Does the image display a region involved in producing antimicrobial peptides or recruiting immune cells for mucosal immunity?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system and provides support to the small or large intestine?", "Is there a structure that serves as a pathway for blood vessels, nerves, and lymphatics to reach the intestines?", "Is there a visible structure through which major blood vessels, such as the superior mesenteric artery or vein, pass?"], "contexual_behavior": [], "functions": ["Is there evidence of arteries, veins, or capillaries delivering blood to and from the intestines?", "Is there a region that appears to house lymphoid tissue or facilitate immune cell movement within the abdomen?", "Can you see a structure that contains lymphatic vessels responsible for draining lymph from the gut?"]}}, "large defect": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an area in the image that measures more than 2 centimeters in its greatest dimension?", "Can you identify a region with a depth exceeding 0.5 centimeters?", "Does the image show a structure with an irregular or oval outline?", "Is there a surface area visible that appears to be greater than 4 square centimeters?", "Can you see a region whose volume might be estimated in several to tens of cubic centimeters?", "Is there an area that appears red, pink, or pale, possibly due to tissue exposure or vascularity?", "Does the image reveal exposed subcutaneous tissue, muscle, or bone?", "Can you identify a region with a width or length greater than 2 centimeters?", "Is there a moist and friable area, possibly containing granulation tissue?", "Does the margin of any region appear irregular, undermined, or rolled?", "Is there evidence of elevated temperature in a localized area, suggesting inflammation?", "Can you see a moist environment, possibly due to exudate or tissue fluid?", "Is there a region where the tissue appears to have a reduced density compared to surrounding intact areas?", "Does any area suggest a tissue pH in the neutral to slightly alkaline range, around 7.0 to 8.5?"], "relational": ["Does the image show an area where tissues such as skin, muscle, or fascia are disrupted or missing?", "Can you identify a region where internal organs like the intestine or liver might be exposed or affected?", "Is there a visible discontinuity in anatomical regions such as the abdominal wall, thoracic wall, scalp, or extremities?", "Does the image display a loss of continuity that borders structures like adjacent muscles, bone, blood vessels, or nerves?", "Is there evidence of disruption to systems such as the musculoskeletal or integumentary system in the image?", "Can you see exposed cell types such as fibroblasts or myocytes due to tissue loss?", "Does the image contain a defect involving anatomical layers like the epidermis, dermis, or subcutaneous fat?", "Is there an area where tissue disruption has resulted in exposure or loss of the normal barrier between body compartments?", "Can you observe a region where internal organs, blood vessels, or nerves might be directly connected through a discontinuity?", "Is there a visible defect affecting body parts such as the abdomen, chest, scalp, or limbs?"], "contexual_behavior": [], "functions": ["Does the image show an area where the body's structural integrity appears significantly compromised?", "Is there evidence of impaired physiological function in any region depicted?", "Can you identify a region where tissue repair seems delayed or incomplete?", "Does the image display an area that might be experiencing impaired regeneration due to its size?", "Is there a visible disruption of normal organ architecture that could lead to functional loss?", "Does any region suggest prolonged inflammation or features consistent with a chronic wound?", "Can you see signs of compromised blood flow, such as pallor or tissue ischemia, in any area?", "Is there evidence of scar formation or incomplete tissue restoration in the depicted structures?", "Does the image show an area where the local immune response might be impaired, increasing susceptibility to infection?", "Can you identify a region where the physiological barrier function appears lost or compromised?", "Is there exposed tissue that could increase the risk of infection?", "Does any area suggest disruption of normal cellular activities, such as reduced proliferation or abnormal cell migration?"]}, "no_questions": {"contexual_properties": ["Does the alignment between the foramen magnum and the spinal canal appear altered, suggesting disruption of the normal anatomical axis?", "Does the image reveal increased pressure or crowding of tissues around the craniovertebral junction due to misalignment of the atlas?", "Is there a reduction in the available space for neural structures within the foramen magnum, potentially due to narrowing and compression at the craniovertebral junction?"], "properties": ["Is there a vertebra present with a bone density of about 1.1 grams per cubic centimeter, within normal limits?", "Does the image show a structure at the base of the skull with a markedly reduced opening, consistent with severe narrowing?", "Is there an opening at the skull base that appears narrowed with irregular bony margins and forward displacement of the top vertebra?"], "relational": ["Does the image show a narrowing at the opening formed by the occipital bone?", "Is there a visible impact on the passage of vertebral arteries or the accessory nerve through the large opening at the base of the skull?", "Is there evidence of disruption to tissues or membranes such as the dura mater surrounding the opening at the skull base?"], "contexual_behavior": ["Is there evidence of reduced space where the brainstem transitions into the spinal cord?", "Does the image reveal any abnormal positioning of the atlas vertebra that could compromise the opening at the skull base?", "Can you identify a misalignment of the first cervical vertebra that might affect the passageway for the spinal cord?"], "functions": ["Is there a misalignment of the first cervical vertebra that could directly reduce the space at the craniovertebral junction?", "Can you identify any obstruction that could impede cerebrospinal fluid flow between the cranial and spinal compartments?", "Is there evidence of vascular structures being compressed at the craniovertebral junction, potentially risking ischemia or venous congestion?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": ["Can you identify a region with variable density, possibly due to necrosis, fibrosis, or effects of treatment?", "Does the image reveal a lesion with increased vascularity, consistent with angiogenesis in response to hypoxic conditions?", "Is there evidence of a lesion that has decreased in size, which could indicate a response to chemotherapy or other therapies?"], "properties": ["Is there a population of cells with an increased nuclear-to-cytoplasmic ratio due to enlarged nuclei?", "Are the cells in the lesion poorly differentiated, lacking normal glandular structures?", "Are there regions of necrosis comprising between 10% and 50% of the mass?"], "relational": ["Is there a visible abnormality involving the pancreas?", "Can you identify lesions or masses in organs such as the liver, lungs, or peritoneum?", "Does the image show evidence of a disease process primarily affecting the digestive system?"], "contexual_behavior": ["Does the tumor appear to have reduced growth rate, potentially as a result of anti-angiogenic therapy and decreased blood supply?", "Can you see a tumor that may be suppressing immune surveillance, for example by expressing immune checkpoint molecules or showing signs of immunosuppressive cytokine activity?", "Can you see alterations in tumor behavior or cell adhesion, possibly due to changes in stromal cell interactions or adhesion molecule expression?"], "functions": ["Can you see a tumor that might be associated with abnormal signaling pathways, such as those involving KRAS, TGF-\u03b2, or PI3K/AKT?", "Is there a structure that could be causing destruction of both exocrine and endocrine tissue, potentially leading to digestive enzyme deficiency or altered glucose regulation?", "Does the image show evidence of a lesion that invades surrounding tissues or adjacent structures?"]}}, "large cervical myoma": {"yes_questions": {"contexual_properties": ["Is there a mass that appears larger in the context of elevated estrogen levels, such as during pregnancy or hormone therapy?", "Can you identify a structure that might decrease in size after menopause or following hormonal suppression therapy?", "Does the image show a mass with irregular or altered shape, possibly due to degeneration, rapid growth, or compression by nearby tissues?", "Is there evidence of calcification within a mass, which could suggest chronic degeneration, especially in a postmenopausal individual?", "Can you see an area within a mass that appears necrotic, possibly due to compromised blood supply such as torsion or rapid enlargement?", "Is there a structure with variable consistency, such as regions that appear hyalinized, cystic, or reddish, indicating different types of degeneration?", "Does the mass contain cystic areas that might result from inadequate blood supply or vascular insufficiency?", "Is there a region within the mass that looks edematous, possibly due to fluid accumulation from venous congestion or degeneration?", "Can you observe increased vascularity in a mass, which could be associated with rapid growth or hormonal stimulation?", "Is there a change in color within the mass, such as reddish or dark areas, that might indicate red degeneration, hemorrhage, or necrosis?", "Does the mass appear more fibrous or firm, suggesting maturation or hyaline degeneration?", "Are there hemorrhagic regions within the mass, possibly due to vascular rupture or red degeneration?", "Can you identify areas that seem softer within the mass, which could be due to cystic or myxoid degeneration or necrosis?", "Is there a firmer region within the mass, possibly resulting from increased collagen deposition or fibrosis?", "Does the mass appear heavier or larger, potentially due to growth, edema, or cystic changes?", "Is there evidence that the mass has decreased in weight or size, possibly after degeneration, necrosis, or medical therapy?", "Can you see signs of degeneration in the mass, such as changes in tissue quality, possibly due to ischemia or hormonal changes?", "Is there a change in the surface texture of the mass, such as roughness or irregularity, which might be due to degeneration, calcification, or cyst formation?", "Does the image show distortion of the cervix, possibly caused by a large or exophytically growing mass?", "Are there areas within the mass that display abnormal tissue composition, such as degeneration, necrosis, or calcification?"], "properties": ["Is there a mass in the image that appears larger than 5 centimeters in diameter?", "Can you identify a structure that might weigh between 100 and 500 grams based on its size and appearance?", "Does the image show a lesion that is round or oval in shape?", "Is there an object with a white to pale pink coloration?", "Can you see a mass that looks firm and rubbery in consistency?", "Is there a structure that could be composed primarily of smooth muscle cells and fibrous tissue?", "Does the mass appear to have moderate water content, possibly around 60\u201370%?", "Is there evidence of moderate vascularity, with blood vessels mainly at the periphery of a mass?", "Can you identify a lesion that might have a high collagen content in its extracellular matrix?", "Does the image show a mass that likely has a low mitotic index, with fewer than 5 mitoses per 10 high-power fields?", "Is there a structure that appears to be growing slowly, possibly less than 1 centimeter per year?", "Can you see a mass whose extracellular matrix might contain collagen, proteoglycans, and fibronectin?", "Is there evidence that the lesion could express estrogen or progesterone receptors?", "Does the mass show any focal or patchy areas that could represent variable calcification?", "Is there a structure with moderate cellular density and densely packed smooth muscle cells?", "Can you identify a mass with well-defined margins separating it from surrounding tissue?", "Does the lesion appear to lack significant areas of necrosis?", "Is there a structure whose blood supply could be derived from branches of the uterine artery?", "Can you see a mass that appears firm and inelastic to palpation?", "Does the image show a lesion with fewer than 1 mitosis per high-power field?"], "relational": ["Does the image show a mass associated with the female reproductive system?", "Is there a structure that appears to originate from the cervical region of the uterus?", "Can you identify a lesion developing within or from the cervix?", "Is there evidence of a mass affecting adjacent organs such as the bladder or rectum?", "Does the image reveal compression of anatomical spaces like the bladder space or rectouterine pouch?", "Can you see a mass that is in close proximity to the vagina or uterine body?", "Is there a structure that could be supplied by the uterine or vaginal arteries?", "Does the image show involvement of cervical layers such as the endocervical mucosa or smooth muscle?", "Is there a mass surrounded by tissues like cervical stroma or connective tissue?", "Can you identify a lesion that may impact reproductive structures such as the fallopian tubes?"], "contexual_behavior": ["Is there a structure in the image that could mechanically obstruct the lower uterine segment and impair normal muscular coordination?", "Can you identify an object that might physically narrow or block the cervical canal, potentially causing menstrual outflow impairment?", "Does the image show a mass that could distort endometrial vessels or increase the endometrial surface area, leading to increased uterine bleeding?", "Is there evidence of something occupying the cervical canal or exerting pressure on cervical tissue that could interfere with cervical dilation during labor?", "Can you see a structure that might block the cervical canal and reduce fertility by preventing sperm passage into the uterine cavity?", "Is there an object that could disrupt cervical canal patency or alter mucus properties, potentially impairing sperm migration?", "Does the image contain a mass that appears to compress the bladder or bladder neck, possibly causing urinary retention?", "Is there a structure that could stretch surrounding pelvic tissues or cause local inflammation, leading to increased pelvic pain during physical activity?", "Can you identify an object that might disrupt the cervical barrier or alter mucus production, increasing susceptibility to ascending infections?", "Does the image show a mass that could interfere with glandular function or compress cervical tissue, potentially disrupting normal cervical mucus production?", "Is there a structure that distorts cervical anatomy or obscures visualization, which could reduce the effectiveness of cervical screening procedures?", "Can you see evidence of a mass whose growth or vascularity might respond to hormonal fluctuations, potentially aggravating symptoms?", "Is there an object that could block or narrow the cervical canal, interfering with the normal passage of menstrual tissue?", "Does the image show a structure that might impair cervical softening or dilation mechanisms, indicating resistance to prostaglandins during labor?", "Can you identify a mass that weakens or distorts cervical tissue structure, potentially increasing the risk of preterm birth by affecting cervical integrity?"], "functions": ["Is there evidence of distortion in the anatomy of the uterus or impairment of its normal function?", "Can you identify a structure that could be responsible for heavy, prolonged, or irregular menstrual bleeding?", "Does the image show features suggestive of increased endometrial surface area or hypervascularity that might lead to abnormal uterine bleeding?", "Is there a mass that could obstruct the cervical canal or interfere with sperm migration, potentially reducing fertility?", "Can you see a structure exerting pressure on the bladder or rectum, possibly causing urinary or bowel symptoms?", "Is there narrowing or blockage of the cervical canal visible, indicating possible cervical stenosis or canal obstruction?", "Does the image show a mass that might interfere with normal uterine contractility or contribute to painful menstruation or labor dysfunction?", "Is there a lesion causing pelvic pain or a sensation of pressure by exerting a mass effect on adjacent tissues?", "Can you identify an obstruction in the birth canal that could increase the risk of labor dystocia or necessitate a cesarean section?", "Is there evidence of altered pelvic blood flow, such as vascular compression or congestion, due to a mass effect?"]}, "no_questions": {"contexual_properties": ["Does the image suggest that the duration of a process has been extended due to unmet therapeutic goals or the need for prolonged exposure?", "Can you identify adjustments in the timing of sample collection that might align with pharmacokinetic profiles or circadian rhythms?", "Is there an indication that temperature conditions have been adjusted to optimize reaction rates or ensure stability?"], "properties": ["Is there any sign that measurement accuracy is important, with an error margin of \u00b15% or less?", "Can you identify any equipment or labeling that suggests pressure settings such as 1 atm or 15 psi are being used?", "Is there evidence of measurements being taken at specific wavelengths, such as 260 nm or 600 nm?"], "relational": ["Does the image show a medical intervention, such as drug administration or surgical procedures, that appears to be coordinated according to a set of instructions?", "Does the image depict a process or procedure such as diagnostic testing or therapeutic administration that appears to be organized in a structured manner?", "Are there medical devices or equipment, like infusion pumps or monitoring devices, being used in a way that suggests compliance with a set of instructions?"], "contexual_behavior": ["Can you detect any indication that blinding might be compromised in a double-blind study due to procedural lapses or unintentional disclosures?", "Does the process appear less effective due to signs of poor participant adherence, possibly from complex instructions or insufficient support?", "Can you identify a scenario where procedures might require modification because of unexpected safety concerns or adverse events?"], "functions": ["Does the scene suggest the presence of safety measures, such as error prevention steps or emergency procedures, to protect patient safety during treatment?", "Is there visual evidence of patient monitoring, such as assessment schedules, outcome measures, or adjustments to interventions based on feedback?", "Is there visual indication of uniform methods or criteria being applied to ensure standardization in diagnosis, treatment, or experimentation?"]}}, "newborn cord around neck": {"yes_questions": {"contexual_properties": [], "properties": ["Can you identify a structure encircling the neck with a length of approximately 55 to 60 centimeters?", "Is there evidence of one or two loops of a tubular structure around the neck region?", "Does the image show a cord-like structure with a thickness of about 1.5 to 2 centimeters near the neck?", "Can you observe a cord with a pearly white to grayish coloration in contact with the neck?", "Is there a visible loop around the neck that appears loose, or does it show signs of being tightly wrapped?", "Can you see a cord-like structure that may contain a gelatinous substance rich in mucopolysaccharides such as hyaluronic acid and chondroitin sulfate?", "Does the distance from the point where the cord attaches to the body to the neck correspond to the length of a looped structure?", "Is there a visible vessel pattern in the cord-like structure around the neck, suggesting the presence of two arteries and one vein?", "Can you detect a coiling pattern in the cord around the neck, with approximately 0.2 to 0.3 coils per centimeter?", "Does the skin beneath the looped structure on the neck appear normal, or is there any redness or indentation present?", "Is there any indication that blood flow through the cord-like structure is maintained, or are there signs of possible compromise due to tightness?"], "relational": ["Is there evidence of a structure encircling the cervical region of a newborn?", "Can you see a cord-like object in direct contact with the skin or soft tissues of the neck?", "Does the image show a looped structure adjacent to the trachea or larynx?", "Is there a visible cord making contact with superficial blood vessels or muscles in the neck area?", "Can you identify a cord that appears to be affecting the respiratory or circulatory systems by its position around the neck?", "Does the cord connect to the abdominal wall or umbilicus while looping around the neck?", "Is there a cord passing around the anterior, lateral, or posterior aspects of the newborn's neck?", "Can you observe a cord interacting with the shoulders, chin, or head of the newborn?", "Is there a structure maintaining a connection between the placenta and the newborn while looping around the neck?", "Does the image show the integumentary system of the neck in contact with a cord-like structure?"], "contexual_behavior": ["Does the image show a situation where a flexible structure is wrapped around the neck of a newborn?", "Can you identify any evidence of a cord-like object encircling the neck region of an infant?", "Is there a visible indication of a structure that could potentially compromise the airway or circulation in a newborn's neck area?", "Does the image depict a scenario that may be associated with perinatal complications involving the neck of a newborn?"], "functions": ["Does the image show a newborn with signs of transient hypoxia or respiratory distress?", "Can you identify any visual evidence of bradycardia or abnormal heart rate in the newborn?", "Is there any indication of compromised oxygen delivery, such as cyanosis or labored breathing?", "Does the newborn display features suggestive of venous congestion or altered blood pressure?", "Can you observe any signs of delayed onset of breathing or need for resuscitation in the newborn?", "Is there visual evidence of increased respiratory effort or tachypnea in the newborn?", "Does the image suggest the presence of birth-related stress responses, such as irritability or increased sympathetic activity?", "Can you see any features that might indicate delayed closure of fetal shunts or incomplete establishment of pulmonary circulation?", "Is there any indication of hypotonia or neurological impairment in the newborn?", "Does the image suggest decreased oxygen saturation or other changes in blood gas status, such as cyanosis or abnormal skin coloration?"]}, "no_questions": {"contexual_properties": ["Is there a feature that becomes more visible with cumulative skin changes associated with increasing age?", "Can you identify an asymmetrical crease that could be related to unilateral sleeping habits, trauma, or localized skin changes?", "Can you identify a feature that is more noticeable in people with cardiovascular risk factors or as part of the natural aging process?"], "properties": ["Is there a visible feature on the ear lobe that is more likely to appear in individuals over 40 years of age?", "Can you see a marking on the ear lobe whose color matches the surrounding skin or is slightly darker?", "Is there a feature on the ear lobe that appears 1 to 3 millimeters wide?"], "relational": ["Does the image display a feature that could be supplied by branches of the posterior auricular or superficial temporal arteries?", "Does the image show a morphological variant located on the lower part of the auricular region?", "Can you identify a superficial feature formed in the skin of the external ear?"], "contexual_behavior": ["Can you see a feature that is more prominent in individuals with diabetes as a result of microvascular complications and connective tissue glycation?", "Does the image contain a visible sign that may indicate altered connective tissue behavior in metabolic syndrome due to changes in the extracellular matrix and chronic inflammation?", "Can you identify a feature that tends to deepen with aging as elastin and collagen fibers degrade?"], "functions": ["Does the image display a feature that may reflect alterations in vascular or connective tissue integrity?", "Is there a crease present that has been studied as a potential clinical indicator of increased cardiovascular risk?", "Can you identify a visible feature that serves as an anatomical marker without participating in physiological processes?"]}}, "anencephaly": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show an individual with a markedly reduced cranial size compared to normal?", "Is there evidence of microcephaly or a head circumference far below the expected range for gestational age?", "Can you identify a case where the cranial vault appears absent or severely underdeveloped, potentially exposing underlying tissue?", "Is there visible neural tissue that appears dark red to purple and has a friable, gelatinous texture?", "Does the image reveal disorganized or incomplete remnants of forebrain and midbrain structures?", "Can you see exposed neural tissue with a disorganized appearance and absence of the cerebrum?", "Is there a near-complete absence of skull bones in the cranial region?", "Does the brain tissue volume appear severely diminished, possibly limited to rudimentary brainstem structures?", "Is there evidence of malformed brainstem or primitive neural elements with no visible cerebral hemispheres?", "Can you infer from the image that the brain weight would likely be significantly below normal, possibly less than 100 grams?"], "relational": ["Does the image show absence or severe malformation of major structures such as the cerebral hemispheres or cranial vault?", "Is there a region of the head where the scalp appears missing or abnormal?", "Can you identify abnormalities affecting the forebrain or midbrain regions?", "Does the image reveal missing parts of the brain such as the cerebral cortex or cerebrum?", "Is there evidence of absent or malformed diencephalon in the cranial area?", "Are the bones of the skull or meninges visibly absent or disrupted?", "Can you see areas where neural tissue is exposed or not covered by cranial bone or skin?", "Is there a failure of cranial bone or overlying ectoderm development visible in the image?", "Does the image suggest a disruption in neural tube closure, particularly at the anterior end?", "Are there visible abnormalities in both the nervous and integumentary systems of the head?", "Can you identify regions where embryological structures such as the neural plate or neural folds may have failed to develop properly?", "Is the interface between the brain and skull altered, with evidence of exposed neural tissue?", "Does the upper facial region or calvaria appear structurally abnormal or incomplete?", "Is there a lack of normal scalp covering the cranial region?", "Are the skull bones missing or severely underdeveloped in the cranial area?"], "contexual_behavior": ["Does the image show evidence of a neural tube defect affecting the development of brain structures during early embryogenesis?", "Can you identify a fetus with malformation or absence of major brain regions that would disrupt central autonomic control?", "Is there a visible absence or severe underdevelopment of the forebrain and cerebrum, suggesting reduced neural control of vital physiological processes?", "Does the image indicate impaired coordination of fetal movement due to missing or underdeveloped motor cortex and neural circuits?", "Can you observe signs of failed sensory processing in the fetus, possibly due to missing sensory relay centers in the brain?", "Is there evidence of disrupted signaling between the brain and other organs, as might occur if neural pathways for inter-organ communication are absent?", "Does the image suggest abnormal regulation of heart rate or respiration that could result from a malformed or absent brainstem?", "Can you see indications that hypothalamic or pituitary structures have failed to develop, potentially affecting neurohormone production?", "Is there a decreased capacity for reflex responses in the fetus, possibly due to incomplete or absent neural circuits in the brain?", "Does the image show a lack of integration of neural pathways necessary for survival after birth, as would be expected if critical brain regions are missing?"], "functions": ["Does the image show an individual with severe malformation of the brain, particularly lacking the cerebral hemispheres and forebrain?", "Can you identify a case where neural regulation of vital physiological processes such as breathing and heart rate appears critically compromised?", "Is there evidence of profound sensory and motor deficits due to missing essential brain structures?", "Does the image suggest inadequate regulation of involuntary functions like blood pressure or digestion, indicating autonomic instability?", "Can you observe signs of impaired respiratory or cardiovascular regulation, such as respiratory failure or abnormal heart function?", "Is there an absence of normal reflexes or basic survival behaviors, possibly due to missing neural circuits in the brainstem or higher centers?", "Does the image indicate disruption of hormonal regulation or homeostasis, such as impaired hypothalamic or pituitary function?", "Can you see evidence of abolished movement coordination or postural instability, potentially due to absent cerebrum and cerebellum?", "Is there a complete lack of consciousness or cognitive function, as might be expected if the cerebral cortex is not developed?", "Does the image suggest a loss of communication between organ systems, possibly due to missing central neural pathways?"]}, "no_questions": {"contexual_properties": ["Does the image reveal cells with abnormal cytoplasmic inclusions under pathological conditions?", "Does the image show increased mitotic figures, suggesting rapid tumor cell proliferation?", "Does the image show an increased number of abnormal cells within lymph nodes, consistent with the progression of Hodgkin lymphoma?"], "properties": ["Is there a cell present that lacks cytoplasmic granules?", "Can you find a cell whose nucleus measures approximately 10 to 20 micrometers in diameter?", "Do you see a cell that expresses CD30 and CD15 surface markers but lacks CD45 and most lineage-specific markers?"], "relational": ["Is there evidence of a cell originating from the B cell or hematopoietic lineage?", "Does the image display a microenvironment such as inflamed lymphoid tissue, a tumor microenvironment, or a germinal center supporting abnormal cells?", "Can you identify a cell interacting with fibroblasts, T lymphocytes, or macrophages within lymphoid tissue?"], "contexual_behavior": ["Does the image show a cell that could be secreting increased levels of cytokines, particularly in the context of immune evasion or interaction with immune suppressive cells?", "Is there a cell whose metabolic activity could be heightened in hypoxic regions of the tumor due to upregulation of glycolytic pathways?", "Does the image show a cell that fails to induce fibrosis in the lymph node microenvironment when fibroblast activation signals are absent?"], "functions": ["Is there visual evidence of increased cellular infiltration or fibrosis within the lymphoid tissue?", "Is there evidence of cells that might be driving the pathogenesis of Hodgkin lymphoma?", "Does the image suggest immune suppression or enhanced tumor growth due to the influence of certain abnormal cells?"]}}}
[ { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basilar skull fracture" ], "question": "is basilar skull fracture present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" } ]	["bone", "calvarium", "basilar skull fracture"]	{"bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image contain a portion of tissue that is contiguous with the endocervix at the squamocolumnar junction?", "Can you identify a region composed mainly of non-keratinized stratified squamous epithelium and underlying connective tissue?", "Is there an area adjacent to both the vagina and the endocervix visible in the image?"], "contexual_behavior": ["Can you see any indication that the passage of sperm might be hindered due to altered mucus quality or changes in the cervical environment?", "Does the image show evidence of impaired mucus production or gland dysfunction due to inflammation?", "Can you see any indication that protective function during menstruation might be reduced due to weakened epithelial barriers or immune defenses?"], "functions": ["Is there a structure that could be modulating its local microenvironment, for example by showing changes in pH-sensitive staining or altered cellular composition?", "Is there evidence of cellular infiltration that could reflect cytokine or chemokine activity?", "Can you see features suggesting the release of inflammatory mediators, such as localized redness or edema?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Can you detect changes in staining that might be related to altered pH, such as after mixing with acidic or basic substances?", "Can you identify tissue sections with decreased staining intensity, possibly due to prolonged exposure to light, air, or improper storage?", "Can you observe areas where the staining appears more intense, suggesting increased concentration from evaporation or addition of more reagent?"], "properties": ["Is there a solution present that might have a pH between 2.0 and 3.5?", "Is there any indication of a compound that, in its active form, would be in a quinone or oxidized state?", "Is there evidence of a compound with low water solubility but high solubility in alcohols such as ethanol or methanol?"], "relational": ["Can you identify structures such as cell nuclei, chromatin, or nucleoli that are distinctly stained?", "Can you observe nuclear staining patterns that differentiate between various cell types in the tissue?", "Is there a visual indication that another stain, such as eosin, periodic acid-Schiff, or Masson's trichrome, has been used alongside the nuclear stain?"], "contexual_behavior": ["Are there regions where nuclear staining is weak, which could be due to prolonged dehydration of the sample?", "Does the image display staining variability in areas with high lipid content, such as uneven or patchy nuclear coloration?", "Is there evidence of unreliable or patchy nuclear staining that could be caused by heavy metal contamination?"], "functions": ["Can you see nuclear highlighting that aids in the identification of structural organization within the tissue?", "Is there visual evidence of a staining agent that enables differentiation of cellular elements in a pathological context?", "Does the image display tissue architecture where nuclei are clearly delineated from the surrounding cytoplasm?"]}}, "basilar skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a fracture involving the base of the skull, particularly in bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Is there a fracture line at the cranial base that appears less than a few millimeters wide?", "Does the image reveal a break limited to the thickness of the cranial base bones, typically only a few millimeters deep?", "Can you see a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Is there a lucent line traversing the base of the skull visible on the image?", "Does the image show an air-fluid level or evidence of pneumocephalus near the base of the skull?", "Can you identify any signs of cerebrospinal fluid leakage in association with a skull base fracture?", "Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Does the image suggest a unilateral fracture at the base of the skull, rather than a bilateral one?", "Is the temporal bone involved in the observed skull base fracture?", "Can you estimate whether the displacement of the fracture at the skull base is minimal, less than 2 millimeters?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?", "Are there air-fluid levels present near the base of the skull, as seen in about 20% to 30% of such fractures?", "On CT imaging, is there a hypodense (lucent) line at the base of the skull relative to the surrounding bone?", "Can you observe bruising patterns such as blue or purple discoloration behind the ear or around the eyes, which may change to yellow-green as they resolve?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Can you identify abnormalities in the anterior, middle, or posterior cranial fossae?", "Is there any indication of injury near the course of cranial nerves like the olfactory, optic, or facial nerves?", "Does the image reveal changes involving foramina such as the foramen magnum or cribriform plate?", "Are there visible alterations adjacent to the inner ear, nasal cavity, or orbit?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?", "Is there evidence of communication between the cranial cavity and spaces such as the subarachnoid space or paranasal sinuses?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Are there signs of disruption in sinuses such as the sphenoid or ethmoid sinus?", "Can you identify exposure or compromise of anatomical pathways like cerebrospinal fluid pathways or the auditory canal?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a disruption in the structural integrity of the skull base that could compromise brain protection?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Can you identify features suggesting a breach between the nasal cavity and cranial cavity, such as a defect in the cribriform plate?", "Does the image reveal any signs that could explain cranial nerve deficits, such as those affecting facial movement, hearing, vision, or swallowing?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?", "Can you see any indications that might increase the risk of infection entering the central nervous system, such as a direct pathway for pathogens?", "Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Are there features present that could facilitate the development of a cerebrospinal fluid leak due to openings in the dura mater or bone?", "Is there any sign of functional impairment, such as altered consciousness, seizures, or focal neurological deficits, that could be explained by a structural abnormality at the skull base?"]}, "no_questions": {"contexual_properties": ["Can you observe changes in the lumen size of a vessel, such as narrowing from plaque growth or dilation from an aneurysm?", "Does any vessel in the image appear less elastic, possibly due to aging or calcification?", "Is there evidence of an aneurysm in a vessel, possibly resulting from wall weakening due to a connective tissue disorder?"], "properties": ["Can you see a vessel whose tissue pH would be expected to be between 7.35 and 7.45?", "Can you identify a vessel that bifurcates into major branches, such as those supplying the anterior and lateral regions of the heart?", "Does the image show a vessel that appears capable of pulsatile expansion and recoil, indicating high elasticity?"], "relational": ["Can you identify a vessel that supplies blood to the myocardium or other layers of the heart wall?", "Can you see a vessel that penetrates the epicardium or myocardium?", "Does the image show a structure that is part of the cardiovascular system?"], "contexual_behavior": ["Is there a vessel that might fail to dilate in response to vasodilators if endothelial dysfunction is present?", "Can you see a vessel that would deliver less oxygen to the heart muscle during anemia because of reduced arterial oxygen content?", "Can you identify a structure whose blood flow might decrease during physical exertion if there is evidence of narrowing or obstruction?"], "functions": ["Can you identify a branching network that supplies blood directly to cardiac tissue?", "Can you identify a vessel that adjusts its diameter in response to increased cardiac workload?", "Does the image suggest the presence of collateral circulation that could protect the heart from ischemia if a primary vessel is blocked?"]}}}
[ { "answer": "multiple fractures very well", "extracted_concepts": [ "image", "multiple fractures" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "multiple fractures" ], "question": "does this image show multiple fractures very well?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basilar skull fracture" ], "question": "is basilar skull fracture present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" } ]	["multiple fractures", "bone", "image", "calvarium", "basilar skull fracture"]	{"multiple fractures": {"yes_questions": {"contexual_properties": ["Is there evidence of increased swelling or edema in the region of acute injury?", "Can you identify areas where bone fragments appear displaced, suggesting instability from high-energy trauma?", "Does the image show abnormal angulation or malalignment at more than one bone site?", "Is there visible limb shortening or overlapping of bone fragments that could be due to muscle contraction or displacement?", "Are there signs of delayed bone healing, such as lack of bridging callus or persistent fracture lines, possibly due to poor vascularity or infection?", "Can you observe any visible deformity or malposition of a limb or bone immediately after injury?", "Is there evidence of increased local temperature or redness, indicating hyperemia during the acute inflammatory phase?", "Do you see changes in bone density, such as osteopenia or areas of callus formation, on the imaging?", "Is there visible bruising or ecchymosis in the soft tissues surrounding the injury site?", "Does the affected area appear to be associated with increased pain sensitivity or hyperalgesia, especially during movement?", "Can you detect abnormal or pathological mobility at one or more bone sites, suggesting instability or nonunion?", "Is there evidence of callus formation indicating the reparative phase of bone healing?", "Do you notice bone misalignment or displacement that could result from inadequate reduction or shifting of fragments?", "Are there changes in limb length, such as shortening, due to overriding bone fragments or bone loss?", "Does the imaging reveal abnormal radiographic features, such as multiple fracture lines or callus, at initial presentation or during healing?"], "properties": ["Does the image show evidence of two or more separate bone breaks?", "Can you identify bone fragments that are each between 2 and 10 centimeters in length?", "Is there visible displacement of bone fragments ranging from 1 to 5 centimeters?", "Does the gap between fractured bone ends appear to be approximately 1 to 3 centimeters wide?", "Can you observe swelling near the site of injury measuring about 3 to 8 centimeters in diameter?", "Is there any indication of blood loss that could be estimated between 500 and 2000 milliliters?", "Are the fractures located in the lower limbs, such as the femur or tibia?", "Do the bone breaks appear to be of transverse, oblique, or comminuted pattern?", "Is there visible angulation at the fracture sites between 10 and 30 degrees?", "Can you see signs of reduced bone density at the sites of injury, possibly below 0.8 g/cm\u00b2?", "Does the severity of the observed injuries appear moderate to severe?", "Is there any visual clue suggesting the affected individual is an adult between 20 and 50 years old?", "Are there signs of elevated tissue temperature around the injury, possibly between 37.5 and 39\u00b0C?", "Can you infer a high level of pain, potentially rated 7 to 10 out of 10, based on the visual presentation?", "Does the image suggest a healing process that might require 8 to 16 weeks depending on the extent and location of the injuries?"], "relational": ["Does the image show evidence of a pathological condition affecting the skeletal system in more than one location?", "Can you identify disruptions in the integrity of the musculoskeletal system involving multiple bones?", "Is there visual indication of injuries involving both the appendicular and axial skeleton?", "Does the image display abnormalities in long bones such as the femur, tibia, or humerus?", "Are there signs of injury in flat bones or the pelvis?", "Can you see affected regions in the limbs, spine, or skull that suggest more than one bone is involved?", "Is there involvement of joints such as the knee, hip, shoulder, or wrist adjacent to areas of bone disruption?", "Does the image show tissues like periosteum, muscle, ligament, tendon, or cartilage connected to visibly damaged bones?", "Are there features suggesting the participation of bone marrow or blood vessels in the healing process at multiple sites?", "Can you identify anatomical structures such as osteoblasts or periosteum that might be supporting repair in more than one area?", "Is there evidence that organ systems like the nervous, vascular, or integumentary systems are structurally impacted in association with bone injuries?", "Does the image show involvement of ligaments or tendons such as the anterior cruciate ligament, patellar tendon, rotator cuff tendons, or Achilles tendon near sites of bone disruption?"], "contexual_behavior": [], "functions": ["Does the image show evidence of structural instability or loss of integrity in more than one location?", "Can you identify signs of impaired function or complications that might arise from injuries affecting multiple sites?", "Is there visual indication of restricted mobility or the use of immobilization devices, such as casts or splints, on more than one limb?", "Does the image suggest reduced movement or the need for assistive support due to injuries at multiple sites?", "Can you observe features that might indicate delayed bone healing, such as abnormal alignment or persistent gaps at multiple injury sites?", "Is there evidence of nonunion or malunion in more than one bone, suggesting impaired healing processes?", "Does the image show signs that could be associated with a heightened inflammatory response, such as swelling or redness at multiple locations?", "Can you identify visual cues of vascular injury, such as bruising or pallor, that might indicate impaired blood flow to tissues?", "Is there evidence of tissue ischemia or impaired perfusion in areas affected by more than one injury?", "Does the image suggest disturbances in calcium or phosphate regulation, such as abnormal bone density or signs of bone resorption?", "Can you see indications that weight-bearing is limited, such as the use of crutches or avoidance of standing on certain limbs?", "Is there visual evidence of muscle weakness, atrophy, or impaired coordination in regions affected by multiple injuries?", "Does the image suggest an increased risk of fat embolism, such as the presence of long bone injuries with marrow exposure?", "Can you identify signs that tissue repair or regeneration may be impaired, such as persistent wounds or delayed closure at multiple sites?", "Is there evidence of a systemic metabolic response, such as muscle wasting or signs of increased energy expenditure, in the context of multiple injuries?", "Does the image suggest activation of the body's stress response, such as features consistent with acute distress or systemic physiological changes?"]}, "no_questions": {"contexual_properties": ["Is there a hyperdense area on a right-sided structure, as might be seen in osteosclerosis or metastatic prostate cancer?", "Can you see thickening of a right-sided structure that might indicate osteosclerosis or Paget\u2019s disease?", "Does the image show erosion on a right-sided structure, which could suggest rheumatoid arthritis or infection?"], "properties": ["Is there a structure on the right side of the skeleton that appears curved and elongated?", "Can you see a right-sided skeletal element that might have a surface area between 100 and 300 square centimeters?", "Does the image show a structure with a porosity likely between 5 and 10 percent?"], "relational": ["Can you see regional arteries, veins, or nutrient arteries supplying a bone on the right side?", "Does the image contain a bone that is adjacent to other bones on the right side?", "Does the image show a bony structure located on the right side of the body?"], "contexual_behavior": ["Does the image show impaired healing on the right surface, which could be associated with diabetes and vascular complications?", "Is there a region on the right where increased bone resorption may be occurring due to inflammation and osteoclast activation?", "Does the image reveal microdamage or signs of repair failure on the right surface, possibly resulting from repetitive stress and insufficient remodeling?"], "functions": ["Is there an object that distributes mechanical forces to reduce impact on joints and absorb shock?", "Is there a visible feature that provides attachment sites for muscles to enable force transmission?", "Can you see an object that acts as a reservoir for minerals such as calcium and phosphorus?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a smooth and slippery surface lining within the abdominal cavity?", "Can you identify a region that might contain fluid rich in water, electrolytes, and proteins?", "Does the image contain a layer likely composed of mesothelial cells?"], "relational": ["Is there a serous lining visible within the abdominal cavity?", "Can you identify a membrane that encloses organs such as the stomach, liver, or intestines?", "Can you identify anatomical spaces such as the greater sac or rectouterine pouch defined by a membranous structure?"], "contexual_behavior": ["Is there a visible reduction in fluid absorption that could be linked to fibrosis or inflammation?", "Can you identify signs of excess fluid accumulation that might result from injury, peritonitis, malignancy, or liver disease?", "Are there indications of impaired healing in a membranous layer after surgical trauma, infection, or poor blood supply?"], "functions": ["Does the image display any signs of adhesions or encapsulated regions that might indicate infection isolation or injury containment?", "Is there a visible structure, such as the greater omentum, that stores fat and serves as an energy reserve or provides insulation?", "Is there evidence of a physical barrier that could help contain infections within the abdominal cavity?"]}}, "image": {"yes_questions": {"contexual_properties": ["Does the image contain areas where features are difficult to distinguish due to reduced clarity, possibly from loss of focus or motion?", "Can you observe regions where the difference between light and dark areas is minimal, making structures hard to see?", "Is there evidence of altered proportions of primary colors, suggesting a change in color balance or white balance?", "Are there parts of the image where individual pixels are visible, indicating insufficient resolution for the display size?", "Do you notice random variations in brightness or color that could indicate increased noise, perhaps from high sensor sensitivity or low light?", "Is there a loss of fine detail that might be due to decreased pixel density or overall resolution?", "Are there areas that appear excessively bright, with loss of detail, suggesting overexposure?", "Does the image contain regions that are unusually dark, with lost detail, possibly due to underexposure?", "Can you see any unwanted visual elements or irregularities that might be artifacts from technical limitations or processing errors?", "Are there places where edges and fine details are less defined, indicating a loss of sharpness?", "Is there any visible alteration in geometric proportions, such as bending or stretching, that could be due to distortion or lens aberration?", "Do you observe regions where the overall luminance is abnormally high or low, suggesting abnormal brightness?", "Are there areas where the intensity of colors appears unusually high or low, indicating altered saturation?", "Can you spot repetitive or unexpected patterns that might result from technical faults or interference?", "Are there shadows present in locations that do not correspond to the expected direction of illumination?", "Is there a noticeable loss of fine structures or details, possibly due to compression, low resolution, or blurring?", "Does the image have a coarse or grainy texture, especially in low-light areas, indicating high noise levels?", "Are there regions where the colors appear reversed, as in a negative image, possibly due to processing errors?", "Do you see areas where the difference between light and dark is exaggerated, making features more pronounced than usual?", "Are there unexpected spots or marks present, which could be due to sensor defects, dust, or artifacts?"], "properties": ["Can you identify an object whose resolution is defined by the number of pixels along its width and height?", "Is there an entity present whose file size would depend on its resolution, color depth, and compression?", "Does the scene include something characterized by a color depth such as 8-bit or 24-bit?", "Can you find an object with an aspect ratio like 4:3 or 16:9?", "Is there a structure whose width in pixels could be specified as 800, 1920, or 3840?", "Can you see something whose height in pixels might be 600, 1080, or 2160?", "Is there an entity that could be stored in formats such as JPEG, PNG, or TIFF?", "Can you identify an object with a bit depth per channel of 8 bits, 12 bits, or 16 bits?", "Is there something whose compression ratio might range from 2:1 to 20:1 depending on its format?", "Can you observe an entity whose average brightness level could be measured on a scale from 0 (black) to 255 (white)?", "Does the scene include something whose contrast level is defined by the difference between its darkest and brightest areas?", "Is there an object whose dynamic range could be expressed in stops or decibels?", "Can you find something with a pixel density measured in dots per inch, such as 72, 150, or 300 DPI?", "Is there an entity that uses a color space like sRGB, Adobe RGB, or CMYK?", "Can you see an object whose noise level could be quantified by signal-to-noise ratio or noise variance?"], "relational": ["Does the image display any structures that could be classified as bones or muscles?", "Can you identify features belonging to the skeletal or cardiovascular systems?", "Is there evidence of anatomical regions such as the thorax or abdomen in the image?", "Does the image show tissues like connective or nervous tissue?", "Can you observe spatial orientation or continuity between anatomical structures?", "Are there cells visible that resemble neurons or adipocytes?", "Does the image include structures adjacent to major blood vessels or ligaments?", "Can you determine if the image is oriented along the sagittal or transverse plane?", "Is there a visible organ such as the heart or kidneys in the image?", "Can you identify anatomical features at the tissue or cellular level?", "Does the image show proximity or overlap between neighboring organs?", "Are muscle tissue and epithelial tissue both present in the image?", "Can you see anatomical relationships that suggest the presence of surrounding tissues?", "Is the head or limbs region represented in the image?", "Does the image capture multiple hierarchical levels, such as both organs and tissues?"], "contexual_behavior": ["Does the image show any signs of reduced clarity or sharpness that could compromise diagnostic interpretation?", "Are there visible artifacts suggesting patient movement that might obscure anatomical details?", "Can you identify the use of contrast agents enhancing the visibility of specific tissues or lesions?", "Does the image appear to have been acquired using advanced techniques such as high-resolution MRI or PET, potentially improving sensitivity for disease detection?", "Is there evidence of low resolution that could limit the detection of subtle anatomical changes important for disease monitoring?", "Does the image suggest challenges in clarity or depth that might be encountered in obese patients during image-guided interventions?", "Can you determine which imaging modality was used, and does it provide unique contrast for differentiating tissue types?", "Is there evidence of 3D reconstruction that enhances spatial orientation and anatomical detail for surgical planning?", "Does the image quality suggest a high or low signal-to-noise ratio, potentially affecting the detection of small structures such as microcalcifications?", "Are there features in the image that highlight metabolic or physiological activity, aiding in tumor localization?", "Is there anatomical overlap present that could obscure regions of interest and compromise diagnostic function?", "Does the image appear to be part of a screening program where patient age or risk factors might influence disease detectability?", "Can you observe the effects of image enhancement processing, such as increased contrast or reduced artifacts, that might improve interpretation?", "Is there evidence of metallic implants causing artifacts that could obscure underlying tissues and hinder early disease detection?", "Does the image include dynamic contrast features that enable visualization of blood flow or vessel patency for vascular assessment?", "Are there motion artifacts present that could reduce the reliability of image-based measurements?", "Can you identify the fusion of information from multiple imaging modalities that might improve diagnostic function?", "Is anatomical visualization sufficient to guide a biopsy, or does poor visualization make target localization difficult?", "Does the image suggest it is being used for therapy monitoring during rapid disease progression, possibly requiring advanced or frequent imaging?", "Are there indications that specific radiotracers were used to enhance the detection of inflammation?"], "functions": ["Does the image provide visualization of internal anatomical structures?", "Can you identify any documentation of clinical findings within the image?", "Is there evidence in the image that could support clinical decision-making?", "Does the image reveal any pathological changes or abnormal findings?", "Can you use the image to aid in disease diagnosis by identifying abnormalities?", "Is there information in the image that could be used to monitor disease progression over time?", "Does the image allow for serial comparison to assess changes in anatomy or function?", "Can the image be used to support treatment planning by localizing lesions or mapping anatomy?", "Is there anatomical detail in the image that would help in targeting areas for intervention?", "Does the image provide real-time visualization or navigation of anatomical landmarks for surgical guidance?", "Can you use the image to detect anatomical abnormalities by assessing structure or function?", "Is there evidence in the image that could be used for organ function assessment, such as functional imaging features?", "Does the image contain information relevant to physiological evaluation of an organ?", "Can the image be used for disease screening or early detection of asymptomatic conditions?", "Is there visual evidence in the image that could facilitate preventive imaging?", "Does the image allow for assessment of therapy response by comparing pre- and post-treatment findings?", "Can you use the image to monitor treatment outcomes or evaluate changes in disease status?", "Is there information in the image that could facilitate image-guided minimally invasive procedures?", "Does the image provide visualization that would assist in procedural navigation during interventions?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see any vessels with wall thickness less than 1 millimeter?", "Is there evidence of multiple dilated veins, possibly more than three, in the same region?", "Are there any nodular, beaded, or grape-like surface features visible on vascular structures?"], "relational": ["Can you see vascular structures surrounded by connective tissue, epithelial tissue, or smooth muscle?", "Can you identify vascular abnormalities in organs like the esophagus, stomach, liver, or rectum?", "Does the image show vascular features that interact with both the digestive and circulatory systems?"], "contexual_behavior": ["Do any veins seem to have reduced mechanical strength, possibly due to chronic hypertension or repeated injury?", "Is there evidence of venous dilation that could be associated with high portal pressure?", "Do any vessels appear less responsive to vasoactive changes, as might occur in advanced liver disease?"], "functions": ["Can you see vascular changes that might compromise tissue oxygenation or suggest local ischemia due to impaired perfusion?", "Is there evidence of fragile vascular structures that might predispose to bleeding complications?", "Does the image show any abnormally dilated veins that could indicate a pathological structure?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any disruption in the continuity of a structure belonging to the skeletal system?", "Is there a visible abnormality adjacent to joints such as the knee, elbow, or wrist?", "Is there evidence of structural damage affecting bones such as the radius, femur, or clavicle?"], "contexual_behavior": ["Is there a bone lesion that could demonstrate impaired callus formation if the patient is malnourished?", "Is there a bone disruption whose healing process could be slowed by corticosteroid use due to osteoblast suppression?", "Can you see a bone injury that might fail to remodel correctly in the context of osteoporosis or decreased bone density?"], "functions": ["Can you identify any structural changes that might result from bone remodeling or repair processes?", "Is there evidence of pain response, such as guarding posture or tissue sensitization, in the affected area?", "Can you observe any changes that might indicate an inflammatory response, such as increased tissue density or redness around a bone?"]}}, "basilar skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a fracture involving the base of the skull, particularly in bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Is there a fracture line at the cranial base that appears less than a few millimeters wide?", "Does the image reveal a break limited to the thickness of the cranial base bones, typically only a few millimeters deep?", "Can you see a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Is there a lucent line traversing the base of the skull visible on the image?", "Does the image show an air-fluid level or evidence of pneumocephalus near the base of the skull?", "Can you identify any signs of cerebrospinal fluid leakage in association with a skull base fracture?", "Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Does the image suggest a unilateral fracture at the base of the skull, rather than a bilateral one?", "Is the temporal bone involved in the observed skull base fracture?", "Can you estimate whether the displacement of the fracture at the skull base is minimal, less than 2 millimeters?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?", "Are there air-fluid levels present near the base of the skull, as seen in about 20% to 30% of such fractures?", "On CT imaging, is there a hypodense (lucent) line at the base of the skull relative to the surrounding bone?", "Can you observe bruising patterns such as blue or purple discoloration behind the ear or around the eyes, which may change to yellow-green as they resolve?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Can you identify abnormalities in the anterior, middle, or posterior cranial fossae?", "Is there any indication of injury near the course of cranial nerves like the olfactory, optic, or facial nerves?", "Does the image reveal changes involving foramina such as the foramen magnum or cribriform plate?", "Are there visible alterations adjacent to the inner ear, nasal cavity, or orbit?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?", "Is there evidence of communication between the cranial cavity and spaces such as the subarachnoid space or paranasal sinuses?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Are there signs of disruption in sinuses such as the sphenoid or ethmoid sinus?", "Can you identify exposure or compromise of anatomical pathways like cerebrospinal fluid pathways or the auditory canal?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a disruption in the structural integrity of the skull base that could compromise brain protection?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Can you identify features suggesting a breach between the nasal cavity and cranial cavity, such as a defect in the cribriform plate?", "Does the image reveal any signs that could explain cranial nerve deficits, such as those affecting facial movement, hearing, vision, or swallowing?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?", "Can you see any indications that might increase the risk of infection entering the central nervous system, such as a direct pathway for pathogens?", "Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Are there features present that could facilitate the development of a cerebrospinal fluid leak due to openings in the dura mater or bone?", "Is there any sign of functional impairment, such as altered consciousness, seizures, or focal neurological deficits, that could be explained by a structural abnormality at the skull base?"]}, "no_questions": {"contexual_properties": ["Does the image show an organ that is in close contact with an adjacent reproductive structure?", "Is there evidence of an anatomical connection between a filtration organ and a gonadal structure on the opposite side?", "Does the image display an abnormal relationship between an excretory organ and an adjacent ovary?"], "properties": ["Is there evidence of an organ from the urinary tract abnormally adherent to a neighboring reproductive organ?", "Does the image display a scenario where a bean-shaped structure is in direct contact with an oval-shaped organ on the opposite side?", "Can you identify a structure that appears to be attached to an organ typically responsible for producing ova?"], "relational": ["Are there visible changes in the position of an organ that suggest it is adherent to a neighboring structure in the pelvic region?", "Is there evidence of scar tissue or connective tissue joining an organ from the urinary system to one from the reproductive system?", "Is there a structure near the ureter, fallopian tube, colon, or adrenal gland that appears abnormally connected to another organ?"], "contexual_behavior": ["Is there a visible change in endocrine function of an organ in response to adjacent ovarian pathology or local hormonal alterations?", "Can you see any indication of chronic pelvic disease that might interfere with blood pressure control by affecting renal perfusion or renin secretion?", "Is there a structure whose ability to regulate electrolyte balance could be compromised by pelvic adhesions?"], "functions": ["Can you see a structure involved in hormone production, such as erythropoietin or the activation of vitamin D?", "Is there evidence of an organ that maintains acid-base balance by reabsorbing bicarbonate and excreting hydrogen ions?", "Can you identify an anatomical relationship where a renal structure is adherent to a reproductive organ?"]}}}
[ { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bilateral cleft palate" ], "question": "is bilateral cleft palate present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" } ]	["bilateral cleft palate", "face"]	{"bilateral cleft palate": {"yes_questions": {"contexual_properties": ["Does the image show a palatal gap that appears wider than usual, possibly indicating a pre-surgical or growing state?", "Can you observe a deepened separation in the palate that might result from vertical growth of the maxilla during childhood?", "Is there evidence of significant tissue deficiency in the palatal region, suggesting a preoperative or delayed repair condition?", "Do you see abnormal tissue characteristics, such as irregular surfaces, that could be associated with chronic inflammation or infection?", "Is there a palatal defect that appears more pronounced, possibly reflecting a period of rapid craniofacial growth without surgical intervention?", "Can you identify areas of redness or purplish discoloration in the palate, which may indicate infection or inflammation?", "Is there visible scar tissue in the palatal region, suggesting previous surgical repair?", "Do you notice swelling in the palate that could be due to recent surgery or acute infection?", "Is the palatal gap visibly reduced, possibly indicating a successful surgical intervention?", "Can you detect the presence of fluid or exudate in the palatal area, which might be due to infection, inflammation, or fistula formation?", "Are there any ulcerations or open sores in the palate that could result from trauma, infection, or poor oral hygiene?", "Do you see abnormal mucosal texture, such as roughness or irregularity, possibly due to repeated infections, scarring, or failed repairs?", "Is the palatal separation less apparent, potentially reflecting tissue remodeling after surgical repair and aging?", "Can you observe signs of bleeding in the palatal region, which may occur during surgery, trauma, or acute infection?", "Is there a visible fistula or abnormal opening in the palate, possibly indicating a postoperative complication or incomplete healing?"], "properties": ["Is there a structure in the image that shows a gap measuring between 5 and 20 millimeters in width?", "Can you identify a separation extending from the incisive foramen to the uvula, with a length of approximately 20 to 40 millimeters?", "Does the image display a shallow to moderate depression, with a depth between 2 and 8 millimeters, in the palatal region?", "Is there a visible V-shaped or U-shaped gap along the midline of the palate?", "Can you see a midline defect affecting both the hard and soft palate symmetrically?", "Does the image show a structure with a frequency of occurrence in live births between 0.02 and 0.05 percent?", "Is there tissue present that appears pink to reddish, possibly with areas of erythema, in the palatal region?", "Can you identify disrupted mucosa, connective tissue, or exposed bone or cartilage within a palatal gap?", "Does the image reveal a complete separation between the palatal shelves, with no fusion at the midline?", "Is there an area where the palatal tissue thickness is reduced to less than 2 millimeters?", "Can you observe an irregular or uneven surface texture, possibly with ulcerations or granulation tissue, in the palate?", "Is there evidence of bony defects in the palatal region, given that such defects are present in more than 90 percent of similar cases?", "Does the image show involvement of both the hard and soft palate, with the hard palate nearly always affected and the soft palate in most cases?", "Can you see discontinuity or compromised integrity of the mucosa, with exposure of underlying structures in the palate?", "Is the distance between two cleft margins in the palatal region within the range of 5 to 20 millimeters?"], "relational": ["Does the image show a disruption involving both the hard and soft regions forming the roof of the oral cavity?", "Can you identify a gap or separation affecting the midline and lateral aspects of the palatal shelves?", "Is there evidence of interrupted continuity in the maxilla or palatine bones within the oral cavity?", "Does the image reveal separation of the mucosal, muscular, and bony layers of the palate?", "Can you observe a defect indicating failure of fusion between the palatal processes of the maxilla?", "Is there a visible abnormality that could impact muscles such as the levator veli palatini or tensor veli palatini?", "Does the image show a structure adjacent to the nasal septum, upper lip, or lateral nasal wall that appears disrupted?", "Are the anatomical boundaries from the alveolar ridge to the uvula and lateral palatal shelves visibly altered?", "Can you detect additional anomalies such as a cleft in the upper lip, irregular dental development, or nasal deformities?", "Is there an abnormal opening between the oral and nasal cavities that could affect speech or feeding?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structural defect that could allow food or liquids to pass from the mouth into the nasal cavity, potentially leading to nasal regurgitation?", "Is there a visible abnormal communication between the oral and nasal spaces that might disrupt normal swallowing or oropharyngeal coordination?", "Can you identify a feature that could prevent proper closure of the velopharyngeal port, possibly resulting in hypernasal speech or articulation difficulties?", "Does the image suggest a condition that would make it difficult for an infant to create suction during feeding, potentially leading to poor intake or prolonged feeding times?", "Is there a structural abnormality that could compromise airway protection during eating or drinking, increasing the risk of aspiration or choking?", "Can you see an oronasal fistula or palatal defect that disrupts the normal separation between the oral and nasal cavities?", "Does the image show a feature that might alter nasal airflow or increase the likelihood of airway obstruction, possibly causing breathing difficulties?", "Is there evidence of a defect that could reduce the ability to generate intraoral pressure, affecting effective sucking, swallowing, or speech sound production?", "Can you identify a structural issue that might impair Eustachian tube function, increasing the risk of recurrent ear infections or middle ear effusion?", "Does the image suggest disturbances in facial growth or dental alignment, such as maxillary deficiency or malocclusion?", "Is there any indication that the individual may have developed compensatory mechanisms, such as atypical speech articulation or altered swallowing patterns, to adapt to a structural defect in the palate?"]}, "no_questions": {"contexual_properties": ["Is there a reduction in fluid volume that might indicate resolution of inflammation or tissue healing?", "Can you detect any area where the fluid has a foul odor, possibly indicating anaerobic bacterial infection?", "Is there evidence of increased fibrin content or fibrin deposition, which might be seen in fibrinous inflammation or coagulation activation?"], "properties": ["Can you see any material that might have a high water content, comprising more than 90% of its volume?", "Is there a fluid that could have a low glucose level compared to plasma?", "Is there a visible fluid whose volume appears variable, ranging from a few milliliters to several liters?"], "relational": ["Is there evidence of abnormal fluid accumulation in the lungs, joints, peritoneum, pleura, or skin?", "Can you see any signs of increased permeability in blood vessels or capillaries, such as fluid or cells escaping into surrounding tissues?", "Does the image display changes in serous, synovial, or mucous membranes that could indicate fluid buildup?"], "contexual_behavior": ["Does the image suggest a reduction in fluid accumulation following infection control and resolution of inflammation?", "Does the image indicate a decrease in fluid accumulation, consistent with the resolution phase of inflammation?", "Can you observe differences in fluid appearance or composition that might reflect varying immune responses to different pathogens?"], "functions": ["Does the image show a substance that might be diluting toxins or dispersing harmful substances in inflamed tissue?", "Does the image suggest the presence of a substance that could be reducing tissue viscosity and forming chemotactic gradients for white blood cell migration?", "Is there a feature that might be delivering nutrients such as proteins, glucose, or electrolytes to damaged tissues?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": ["Can you identify a sample where gene amplification for a particular receptor is undetectable by fluorescence in situ hybridization?", "Does the image depict tissue where a protein is not overexpressed or is absent, resulting in a negative status?", "Does the image suggest a status conversion, where previous overexpression or gene amplification is no longer present on follow-up testing?"], "properties": ["Is there a tissue sample where the fluorescence in situ hybridization ratio for a certain gene is below 2.0?", "Does the image show a tissue sample with absent or very low levels of a certain receptor protein overexpression?", "Can you identify a sample with low mRNA expression of a specific gene, below the diagnostic threshold?"], "relational": ["Can you identify ductal or glandular epithelial structures that are typically assessed in biomarker testing?", "Is there a lesion or tumor in the breast, stomach, or esophagus that could be the focus of biomarker analysis?", "Can you see evidence of other biomarkers such as estrogen receptor, progesterone receptor, or EGFR in the tissue sample?"], "contexual_behavior": ["Is there any indication that the tumor is progressing more slowly, consistent with the absence of HER2 amplification?", "Is there less disruption of adjacent normal tissues, suggesting reduced paracrine signaling from the tumor?", "Does the tumor microenvironment show diminished angiogenesis, possibly due to reduced HER2-driven pro-angiogenic signaling?"], "functions": ["Is there a tumor whose biological behavior and therapeutic response are influenced by the lack of a particular receptor's expression?", "Does the image show a tumor with lower cell proliferation rates compared to those typically driven by mitogenic signaling from a particular receptor?", "Can you identify a tumor that might interact differently with the immune system, lacking immune evasion mechanisms associated with overexpression of a certain receptor?"]}}}
[ { "answer": "before disease and after excellent", "extracted_concepts": [ "disease" ], "question": "when does this image show photos of lady?" }, { "answer": "after excellent", "extracted_concepts": [ "disease" ], "question": "when does this image show photos of lady before disease and?" }, { "answer": "photos of lady before disease and after excellent", "extracted_concepts": [ "disease" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "disease" ], "question": "does this image show photos of lady before disease and after excellent?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "cushings disease", "extracted_concepts": [ "cushings disease" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "cushings disease" ], "question": "is cushings disease present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "cushings disease", "extracted_concepts": [ "cushings disease" ], "question": "what is present?" } ]	["disease", "cushings disease", "face"]	{"disease": {"yes_questions": {"contexual_properties": ["Does the image show any area where pathological processes appear intensified or complications have developed?", "Can you identify a region where tissue damage seems to have advanced or where healing is visible?", "Is there evidence of a lesion whose appearance has changed, suggesting evolution, healing, or worsening?", "Does the image display a mass whose size appears increased, possibly due to cell proliferation or accumulation of abnormal material?", "Is there a mass or swelling that seems to have decreased in size, indicating regression or cell death?", "Can you observe any change in color of a visible manifestation, such as increased redness, bluish discoloration, or darkening?", "Does the composition of any deposit appear altered, possibly due to accumulation of new substances?", "Is there a region where tissue density seems increased or decreased, suggesting fibrosis, edema, or tissue loss?", "Can you see an area with an increased or decreased number of cells, indicating proliferation, infiltration, or cell depletion?", "Does any lesion appear irregular in structure, possibly due to abnormal growth, degeneration, or remodeling?", "Is there a visible area where swelling has increased or decreased, suggesting fluid accumulation or resorption?", "Can you identify a region where the texture appears changed, such as becoming firmer, softer, or showing signs of tissue breakdown?", "Is there an organ that appears larger or smaller than expected, suggesting hypertrophy, atrophy, or infiltration?"], "properties": ["Does the image suggest the presence of a condition that could be classified as acute, subacute, or chronic based on its duration?", "Can you identify signs that might indicate whether the affected individual is pediatric, adult, or geriatric in age of onset?", "Does the visual presentation suggest a mild, moderate, or severe clinical severity?", "Is there evidence of a condition that appears to progress rapidly, gradually, or remain stable over time?", "Can you infer if there is a time interval between exposure and symptom onset, indicating an incubation period?", "Does the image provide clues about the likelihood of recurrence after apparent recovery?", "Is there any indication of the proportion of affected individuals who may not survive, suggesting a mortality rate?", "Can you estimate the prevalence of the condition in the depicted population based on the image?", "Does the image allow you to infer the incidence rate by showing new cases over a specific time period?", "Is there evidence that symptoms resolve in some individuals, suggesting a remission rate?", "Can you estimate the typical duration from onset to resolution of symptoms, indicating recovery time?", "Does the image suggest that symptoms may return after remission, implying a relapse rate?", "Is there any indication of the proportion of diagnosed cases resulting in death, reflecting a case fatality rate?", "Can you infer the age distribution of the affected individuals from the image?", "Does the image provide information about the gender distribution among those affected?", "Is there evidence to estimate the average length of time symptoms persist, indicating symptom duration?", "Can you infer the latency period between exposure and symptom onset from the visual information?", "Does the image suggest the number of symptoms present, as might be described in diagnostic criteria?", "Can you classify the temporal pattern of the condition as acute, chronic, or subacute based on the image?", "Is there any indication of the interval from symptom onset to confirmed diagnosis, reflecting time to diagnosis?"], "relational": ["Is there evidence of changes in the respiratory, cardiovascular, or nervous systems in the image?", "Can you identify alterations in organs such as the lungs, liver, skin, or kidneys?", "Does the image show any abnormalities in blood vessels, joints, or mucous membranes?", "Are there visible changes in the thoracic, abdominal, or cranial regions?", "Can you observe signs of dysfunction, inflammation, or degeneration in any organ system?", "Does the image suggest disruption of nerve pathways, blood circulation, or lymphatic drainage?", "Are there visible entry points such as the nasal cavity, oral cavity, or skin lesions?", "Can you detect interactions between the immune, endocrine, or circulatory systems?", "Is there evidence of anatomical barriers like the blood-brain barrier, mucosal barrier, or skin influencing the spread of a condition?", "Do you see any impact on cellular components such as epithelial cells, neurons, or immune cells?"], "contexual_behavior": ["Is there evidence of a condition that appears more severe in the context of diminished host immune defenses?", "Can you identify a process that becomes more aggressive under chronic stress, possibly due to hormonal or immunological changes?", "Does the image suggest a scenario where adaptive immunity, such as that induced by vaccination, leads to reduced severity of a pathological process?", "Is there a persistent abnormality that could be explained by impaired tissue repair or compromised regenerative capacity?", "Can you see signs of recurrence that might follow incomplete treatment, such as residual abnormal cells or pathogens?", "Is there an indication of accelerated progression in the presence of co-infections or multiple concurrent pathological agents?", "Does the image show a process that appears less active, possibly corresponding to a remission phase with reduced symptoms?", "Can you identify features suggesting increased resistance to standard therapies, such as evidence of genetic mutations or adaptive changes?", "Is there variation in symptoms or manifestations that could be attributed to differences among age groups?", "Does the abnormality appear to progress more rapidly in individuals with signs of immune compromise?", "Is there evidence of impaired clearance, potentially due to genetic mutations affecting immune or metabolic function?", "Can you see indications that the activity of a pathological process is increased during pregnancy, possibly due to hormonal or immunological changes?", "Is there a reduced responsiveness to environmental triggers, suggesting the development of tolerance or decreased receptor sensitivity?", "Does the process fail to activate typical defense mechanisms, possibly due to defects in innate or adaptive immunity?", "Are there signs that the behavior of the abnormality is altered in the presence of metabolic disorders?", "Can you identify features suggesting spontaneous remission under certain physiological conditions, such as immune reconstitution?", "Is there evidence that exposure to specific toxins has worsened tissue damage or disrupted normal cellular function?", "Does the abnormality show delayed onset after initial exposure, indicating a possible latent or incubation phase?", "Are there signs of increased severity in the context of poor nutrition or nutrient deficiency?", "Can you see changes in the function or activity of the abnormality during periods of hormonal fluctuation or endocrine alterations?"], "functions": ["Does the image show evidence of abnormal changes that could impair normal physiological functions?", "Can you identify any signs of disrupted biochemical pathways or organ system activities?", "Is there visual indication of tissue damage or loss of normal organ function?", "Does the image suggest instability or imbalance in regulatory mechanisms responsible for maintaining homeostasis?", "Are there features that point to either excessive or inadequate immune system activity, such as inflammation or immune suppression?", "Can you see any signs of metabolic disturbance, such as abnormal tissue accumulation or altered energy-related structures?", "Is there evidence of impaired tissue repair, chronic inflammation, or fibrosis in the depicted structures?", "Does the image reveal structural or functional abnormalities that could explain clinical symptoms?", "Are there visual cues suggesting disruption in cellular signaling or receptor function within the tissues?", "Can you identify features that indicate weakened defense mechanisms, such as compromised barriers or increased susceptibility to damage?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a structure that contains stratified squamous epithelial cells and smooth muscle cells?", "Is there evidence of elastic fibers comprising around 2 to 5 percent of the dry weight in a tubular structure?", "Is there evidence of a moderate vascular network, such as submucosal capillaries, within a tubular structure?"], "relational": ["Is there an object that passes through the neck, thorax, and upper abdomen?", "Can you identify a tubular structure that connects the pharynx to the stomach?", "Is there a visible junction where a tubular structure meets the stomach, forming a lower sphincter?"], "contexual_behavior": [], "functions": ["Does the image show a region where peristalsis might occur to move a swallowed bolus?", "Is there evidence of a barrier that could prevent stomach contents from moving back toward the throat?", "Does the image contain a region that would facilitate the passage of both liquids and solids by adjusting muscular activity?"]}}, "cushings disease": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any abnormalities in organs that are part of the endocrine system?", "Can you identify a gland that could be producing excess adrenocorticotropic hormone?", "Is there a visible structure that interacts with both the hypothalamus and adrenal glands?", "Does the image contain evidence of changes in tissues such as skin, muscle, bone, or adipose tissue?", "Can you see anatomical features that suggest involvement of the pituitary gland?", "Is there a visible connection between the hypothalamus and the pituitary gland, such as the pituitary stalk?", "Does the image show any indication of altered structures in the face, abdomen, or limbs?", "Can you identify features that might be associated with increased cortisol production in the adrenal cortex?", "Is there evidence of changes that could be explained by disruption of the hypothalamic-pituitary-adrenal axis?", "Does the image show any glands that are regulated by both the hypothalamus and pituitary gland?"], "contexual_behavior": [], "functions": ["Does the image show signs of central or truncal obesity?", "Is there evidence of abnormal fat distribution, such as a rounded facial appearance or a dorsocervical fat pad?", "Can you observe features consistent with muscle atrophy or proximal muscle weakness?", "Is there any indication of skin changes, such as delayed wound healing or thinning?", "Does the image suggest elevated blood pressure or features associated with hypertension?", "Are there visual cues of osteoporosis or decreased bone density?", "Can you identify signs that may indicate impaired glucose regulation, such as features of hyperglycemia?", "Is there evidence of increased susceptibility to infections, such as visible skin lesions or poor healing?", "Does the image show characteristics that could be related to reproductive dysfunction, such as menstrual irregularities?", "Are there signs suggestive of altered stress response or disruption of the hypothalamic-pituitary-adrenal axis?", "Can you observe features that might be associated with sodium retention or hypokalemia, such as edema or muscle weakness?", "Is there any indication of metabolic disturbances, such as dyslipidemia or insulin resistance?"]}, "no_questions": {"contexual_properties": ["Does the image show any evidence of abnormal deposits within blood vessels?", "Is there a visible indication of changes in blood vessel walls that could be associated with pathological processes?", "Can you identify vascular structures that appear altered or affected by extracellular material?"], "properties": ["Can you identify areas where amyloid beta peptides, such as A\u03b240 or A\u03b242, might be present?", "Can you observe vessel wall deposits with moderate to high density?", "Can you identify deposits ranging from 1 to 10 micrometers in diameter?"], "relational": ["Is there any sign of disruption to the blood-brain barrier, such as hemorrhage or impaired homeostasis in brain tissue?", "Does the image suggest the presence of amyloid-beta deposits, particularly A\u03b240 or A\u03b242, within cerebral vessels?", "Can you see signs of amyloid deposition within the walls of cerebral arteries, possibly leading to vessel fragility?"], "contexual_behavior": ["Does the image show changes in blood vessels that could be associated with pathological protein accumulation?", "Can you identify any vascular structures that appear altered or affected by extracellular material?", "Is there evidence in the image of abnormal deposits within blood vessel walls?"], "functions": ["Can you see vessels with reduced reactivity, possibly due to endothelial or smooth muscle cell damage?", "Does the image display signs of vessel narrowing or obstruction that might indicate hypoperfusion?", "Are there signs of impaired regulation of cerebral perfusion, such as abnormal vascular responsiveness?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the imaging reveal a lucent line traversing the skull base, possibly accompanied by air-fluid levels or bone fragments?", "Does the image show air-fluid levels within the paranasal sinuses, which could be present in up to 30% of such cases?", "Is there evidence of a fracture involving the base of the skull, particularly affecting bones such as the temporal, occipital, sphenoid, or ethmoid?"], "relational": ["Does the image reveal disruption of anatomical barriers separating the base of the skull from the brain, such as the dura mater or cranial fossae?", "Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Are the adjacent meningeal layers, including dura mater, arachnoid mater, or pia mater, affected in the image?"], "contexual_behavior": [], "functions": ["Is there visual evidence of a dural tear or rhinorrhea that might indicate disrupted cerebrospinal fluid dynamics?", "Does the image show possible injury to vascular structures at the skull base, such as the carotid artery or venous sinuses, that could lead to hemorrhage or thrombosis?", "Can you see any abnormalities that might increase the risk of central nervous system infection, such as direct communication between the nasal or ear cavities and intracranial space?"]}}}
[ { "answer": "close-up natural color dr garcia tumors b67", "extracted_concepts": [ "tumors" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [], "question": "does this image show close-up natural color dr garcia tumors b67?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "meningioma in posterior fossa", "extracted_concepts": [ "posterior fossa", "meningioma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "posterior fossa", "meningioma" ], "question": "is meningioma in posterior fossa present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "meningioma in posterior fossa", "extracted_concepts": [ "posterior fossa", "meningioma" ], "question": "what is present?" } ]	["bone", "tumors", "calvarium", "posterior fossa", "meningioma"]	{"bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is the molecular weight of the observed protein less than 384 kDa, suggesting a truncating mutation?", "Is there evidence of amino acid changes such as Glu2856Lys, Ser1982Arg, or Trp2626Cys in the gene sequence shown?", "Can you identify a frameshift mutation, and if so, is it more prevalent than a missense mutation in the sample?"], "relational": ["Can you see any organ that might be relevant to hereditary breast and ovarian cancer syndrome?", "Is there evidence of a structure composed of nucleated cells that could be affected by inherited mutations present in both somatic and germ cells?", "Does the image show any tissue or organ commonly affected by hereditary cancer syndromes involving genes such as BRCA2 or BRCA1?"], "contexual_behavior": [], "functions": ["Is there evidence of increased susceptibility to cancers like breast, ovarian, or prostate cancer in the tissue sample?", "Does the image show evidence of impaired DNA repair or increased risk of tumor formation?", "Does the image display features consistent with cell cycle dysregulation or checkpoint failure, such as uncontrolled cell division?"]}}, "tumors": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to be increasing in size, suggesting active cell division or growth?", "Can you identify an area that seems to have decreased in size, possibly indicating a response to therapy or immune activity?", "Does the image show a region with altered coloration that could be due to changes in blood supply, necrosis, or hemorrhage?", "Is there evidence of increased vascularization in any structure, which might suggest angiogenesis stimulated by growth factors?", "Can you see a region that appears necrotic, possibly due to insufficient blood supply or rapid expansion?", "Is there a visible area with calcifications, which could result from chronic necrosis or degeneration?", "Does the image show a structure with cystic features, such as central degeneration or fluid accumulation?", "Can you identify a region with variable density, possibly reflecting differences in cellularity, fibrosis, necrosis, or calcification?", "Is there an area that appears firmer or denser, which might be due to increased fibrosis or a desmoplastic reaction?", "Do you see a region that looks softened, perhaps as a result of necrosis, liquefaction, or cyst formation?", "Is there evidence of increased cellularity in any structure, which could indicate rapid proliferation or a high-grade lesion?", "Does any area display irregular borders, suggesting invasion into surrounding tissues or loss of encapsulation?", "Can you identify a region with mixed composition, such as areas of necrosis, hemorrhage, fibrosis, or cystic change?", "Is there a structure that appears hypermetabolic, possibly due to rapid growth or malignant transformation?", "Do you see a surface defect or ulceration, which might result from outgrowing the blood supply or invasion of overlying tissue?", "Is there evidence of hemorrhage within a structure, possibly due to fragile new blood vessels or vascular invasion?", "Can you observe any changes that might correspond to fluctuations in marker levels, such as progression, recurrence, or response to treatment?", "Does any region appear more heterogeneous, potentially due to genetic mutations, necrosis, or hemorrhage?", "Is there a structure that seems to have lost its capsule and is infiltrating adjacent tissues, indicating invasive behavior?", "Do you see signs of edema, such as swelling or fluid accumulation, which could result from disrupted vasculature or inflammation?"], "properties": ["Is there a mass in the image whose size appears variable, ranging from a few millimeters to several centimeters?", "Can you identify a structure that could weigh anywhere from less than a gram to several kilograms, depending on its characteristics?", "Does the image show a mass with an irregular, nodular, or spherical shape?", "Is there an area that appears pale, gray, white, red, or yellow in color, possibly reflecting differences in vascularity or necrosis?", "Can you see a structure that looks firm, hard, soft, or gelatinous in consistency?", "Is there a mass that might be composed of neoplastic, stromal, inflammatory, or endothelial cells?", "Does the image suggest a region where cell division is elevated compared to surrounding tissue?", "Is there evidence of a structure that could be growing more rapidly than the adjacent normal tissue?", "Can you identify an area with increased or heterogeneous vascularity, possibly due to angiogenesis?", "Does the image show a region that might contain significant necrotic content, especially in rapidly growing or poorly vascularized areas?", "Is there a mass with density higher than that of the surrounding tissue, or with variable density depending on its composition?", "Can you see a structure that might have a high water content, similar to or slightly less than normal tissue?", "Is there an area that could be associated with altered protein expression, such as overexpression or loss of markers like Ki-67, p53, or HER2?", "Does the image suggest the presence of cells with abnormal DNA content, such as aneuploidy or increased DNA replication?", "Is there a region that could have a lower pH, possibly between 6.5 and 7.0, due to increased glycolysis?", "Can you identify an area that might be hypoxic, with reduced oxygen concentration compared to normal tissue?", "Does the image show a region where glucose uptake or concentration might be elevated?", "Is there a mass that could have increased lipid content, particularly if it resembles tissue types like liposarcoma?", "Can you see evidence of high cellular atypia, such as pleomorphism or abnormal cell morphology?", "Is there a region where the nuclear-to-cytoplasmic ratio appears increased, indicating larger nuclei relative to cytoplasm?"], "relational": ["Does the image show an abnormal mass originating from epithelial, connective, muscle, or nervous tissue?", "Can you identify a lesion present within the lung, liver, breast, colon, or brain?", "Is there a structure that could impact the nervous, respiratory, digestive, or endocrine system?", "Does the image display a mass adjacent to blood vessels, nerves, lymph nodes, or other organs?", "Can you see a region containing neoplastic, stromal, immune, or endothelial cells?", "Is there evidence of arterioles, capillaries, venules, or newly formed blood vessels supplying a mass?", "Does the image show lymphatic vessels, regional lymph nodes, or lymphatic capillaries interacting with a suspicious structure?", "Is there an abnormality located in the head and neck, thorax, abdomen, pelvis, or extremities?", "Can you observe a mass interacting with surrounding connective tissue, possibly through invasion or tissue remodeling?", "Is there a structure that appears to cross anatomical barriers such as the basement membrane, blood-brain barrier, serosal membranes, or fascia?"], "contexual_behavior": ["Is there a structure in the image that appears to have increased blood vessel formation, possibly indicating enhanced angiogenesis?", "Can you identify an area that might be resisting immune cell infiltration or showing signs of immune evasion?", "Does the image show a region where cells could be adapting to low oxygen by increasing glycolytic activity?", "Is there evidence of a mass that might be less responsive to chemotherapy, suggesting drug resistance?", "Can you see a structure that appears to be invading surrounding tissues, possibly in response to inflammation?", "Is there a mass that seems to be disrupting the normal architecture of nearby tissue, potentially suppressing local function?", "Does the image show a region where growth rate appears reduced, possibly due to nutrient deprivation or metabolic adaptation?", "Can you identify an area where cells might be avoiding programmed cell death, suggesting evasion of apoptosis?", "Is there a mass that appears to have decreased proliferation, possibly following radiation therapy?", "Does the image show a region that could be secreting immunosuppressive factors, as indicated by reduced immune cell presence nearby?", "Is there evidence of altered cell adhesion or motility in response to hormonal influence, possibly affecting metastatic potential?", "Can you see a mass that is compressing or infiltrating adjacent organs, potentially causing dysfunction due to mass effect?", "Is there a region where increased glycolysis might be occurring in response to low oxygen levels?", "Does the image show an area where antigen presentation to immune cells may be reduced, possibly due to downregulation of MHC molecules?", "Can you identify a structure that might be adapting its behavior in response to targeted therapy, such as by activating alternative signaling pathways?", "Is there evidence of increased production of growth factors to support proliferation and new blood vessel formation?", "Does the image show a mass with reduced growth, possibly following anti-angiogenic treatment and decreased vascular supply?", "Can you see a region that appears to be recruiting stromal cells, as indicated by increased presence of supporting cell types?", "Is there evidence of impaired cell cycle regulation, possibly due to genetic mutations affecting regulatory genes?", "Does the image show a structure that might be resisting oxidative stress, as suggested by features indicating upregulated antioxidant defenses?"], "functions": ["Does the image show a region where cell growth appears uncontrolled or excessive compared to surrounding tissue?", "Can you identify an area that seems to invade or disrupt the normal architecture of adjacent structures?", "Is there evidence of a mass compressing nearby anatomical features or altering organ performance?", "Does the image reveal a structure that could be dysregulating the cell cycle or promoting genetic instability?", "Can you see a region where abnormal cell proliferation might be driven by sustained mitogenic signaling?", "Is there a visible area that could be evading immune detection, such as by lacking typical antigen presentation markers?", "Does the image show evidence of new blood vessel formation, possibly due to secretion of vascular endothelial growth factors?", "Can you identify a structure that appears to degrade the extracellular matrix or invade surrounding tissues?", "Is there a region that might be entering blood or lymphatic vessels, suggesting potential for metastasis?", "Does the image display features consistent with increased glycolysis or altered metabolic activity in a localized area?", "Can you see a structure that seems resistant to programmed cell death, such as by persisting despite cellular stress or damage?", "Is there evidence of recruitment or activation of stromal cells in the vicinity of an abnormal mass?", "Does the image show signs of chronic inflammation, such as accumulation of inflammatory cells near a suspicious area?", "Can you identify a region that might be producing ectopic hormones or disrupting normal endocrine feedback?", "Is there a visible interaction between an abnormal structure and immune or stromal cells, such as recruitment of fibroblasts or macrophages?", "Does the image reveal obstruction of ducts or vessels, tissue necrosis, or impairment of physiological processes in association with a mass?"]}, "no_questions": {"contexual_properties": ["Does the image reveal multiple implants or masses distributed over the peritoneal surfaces of the uterus or ovaries?", "Can you identify any lesions or nodules present on the serosal surfaces of pelvic organs?", "Does the image show evidence of abnormal tissue growth on the outer surfaces of reproductive organs such as the uterus or ovaries?"], "properties": ["Are there visual signs of disease affecting both the uterus and ovaries at their outermost layers?", "Does the image reveal multiple abnormal masses distributed across the serosal surfaces of pelvic organs?", "Does the image show abnormal tissue growths on the outer surfaces of pelvic reproductive organs?"], "relational": ["Are there any signs of spread to other pelvic or abdominal organs, including the omentum or intestines?", "Does the image reveal changes on the uterine or ovarian surfaces consistent with involvement of the pelvic peritoneum?", "Can you see any signs of disease on tissues adjacent to the uterus or ovaries, such as the bladder or rectum?"], "contexual_behavior": ["Does the image reveal any irregularities or masses on the surfaces of organs within the pelvic cavity?", "Is there visual indication of metastatic deposits on the peritoneal surfaces adjacent to female reproductive structures?", "Does the image show evidence of abnormal growths on the outer surfaces of reproductive organs such as the uterus or ovaries?"], "functions": ["Can you identify any features that might indicate lymphatic obstruction or capillary leakage in the pelvic region?", "Does the image show evidence of tumor spread or local invasion affecting the serosal surfaces of pelvic organs?", "Can you observe any features that might suggest an immunosuppressive or pro-inflammatory microenvironment on the serosal surfaces of the uterus or ovaries?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Does any film or layer look irregular, which could be a result of uneven deposition, erosion, or localized damage?", "Is there a surface in the image that appears thicker due to accumulation of material or increased cellularity?", "Is there a structure that looks friable, which could be due to degeneration, inflammation, or enzymatic breakdown?"], "properties": ["Is there a cell present that appears translucent or has a pale cytoplasm under the microscope?", "Can you see a cell that may express proteins like integrins, cadherins, or focal adhesion kinases?", "Is there a cell that appears to be attached to a substrate with significant adhesion strength?"], "relational": ["Is there a structure composed of cells like fibroblasts or collagen-producing cells forming connections between organs?", "Can you identify scar tissue forming a pathological connection between organs?", "Can you identify abnormal boundaries or fibrous bridges joining adjacent organs or compartments?"], "contexual_behavior": ["Can you identify areas where cells appear to have lost adhesion, as might occur during metastasis or cancer progression?", "Do you observe cells modulating their attachment as part of the wound healing and re-epithelialization process?", "Does the image show cells at a wound site during the proliferative phase of tissue repair, where increased attachment and migration are expected?"], "functions": ["Are there signs of cells guiding tissue development, such as organized positioning or differentiation patterns?", "Are there visible features suggesting cell migration or tissue repair, such as cells moving toward an injury site?", "Is there evidence of cells forming stable attachments that maintain tissue architecture and cohesion?"]}}, "posterior fossa": {"yes_questions": {"contexual_properties": ["Is there evidence of an enlarged space that could suggest Dandy-Walker malformation or an arachnoid cyst?", "Can you identify a region that appears compressed, possibly due to a mass such as a tumor or severe swelling?", "Does the image show abnormal fluid accumulation that might indicate hydrocephalus or a cystic malformation?", "Is there a visibly reduced volume in a region that could result from congenital hypoplasia or prior surgical removal?", "Are there structural abnormalities present that might be due to congenital anomalies, trauma, or neoplastic processes?", "Can you see an abnormal mass that could represent a medulloblastoma or ependymoma?", "Is there any displacement of structures that might be caused by mass effect from a tumor, hemorrhage, or edema?", "Does a region appear crowded, as might be seen in Chiari malformation or with reduced cerebrospinal fluid space?", "Is there any indication of increased pressure, such as swelling or compression, that could be due to a tumor, hemorrhage, or obstructive hydrocephalus?", "Can you observe an altered shape in a region that might result from a congenital malformation or surgical intervention?", "Is there evidence of hemorrhage that could be associated with trauma, vascular malformation, or hypertensive crisis?", "Do you see calcifications that might be linked to a tumor, chronic infection, or congenital disorder?", "Are there cystic changes present that could suggest an arachnoid cyst, cystic tumor, or Dandy-Walker malformation?", "Is there visible edema that could be related to acute infarction, tumor, or infection?", "Can you detect changes in tissue density that might indicate infarct, tumor, or hemorrhage?"], "properties": ["Is there a region in the image that appears concave and roughly triangular in sagittal section?", "Can you identify an area bounded posteriorly by the occipital bone, laterally by the petrous part of the temporal bones, and anteriorly by the dorsum sellae?", "Does the image show a space containing neural tissue, meninges, cerebrospinal fluid, and blood vessels?", "Is there a compartment where the brain tissue appears grayish-white and the surrounding fluid is clear?", "Can you see a structure with an estimated volume between 150 and 200 milliliters?", "Is there a region with a width of about 6 to 7 centimeters, a height of 5 to 6 centimeters, and a depth of 4 to 5 centimeters?", "Does the image include an area where the surrounding bone thickness is approximately 4 to 8 millimeters?", "Can you identify a space with a surface area estimated between 60 and 80 square centimeters?", "Is there a compartment where the cerebrospinal fluid volume is approximately 20 to 30 milliliters?", "Does the image show a region where the density of brain tissue is around 30 to 40 Hounsfield units and the surrounding fluid is near zero on CT imaging?", "Can you see an area where the cerebrospinal fluid pressure would typically be between 7 and 15 mmHg?", "Is there a region likely to contain neurons, glial cells, endothelial cells, and meningeal cells?", "Does the image include a space where the cerebrospinal fluid pH is expected to be between 7.31 and 7.34?"], "relational": ["Does the image show a region located at the base of the skull within the cranial cavity?", "Can you identify an area that is bounded by the occipital bone, temporal bones, and part of the sphenoid bone?", "Is there a space containing major brain structures such as the cerebellum, pons, or medulla oblongata?", "Does the image include a region where the cerebellum occupies most of the space?", "Can you see an area that houses the brainstem, including the pons and medulla?", "Is there evidence of cranial nerves V through XII passing through a particular region?", "Does the image show vascular structures such as the vertebral arteries, basilar artery, or dural venous sinuses in a specific area?", "Can you identify dural folds like the tentorium cerebelli or falx cerebelli within the image?", "Is there a region adjacent to the middle cranial fossa or the foramen magnum?", "Does the image display foramina such as the foramen magnum, jugular foramen, internal acoustic meatus, or hypoglossal canal in a particular area?"], "contexual_behavior": ["Does the image show evidence of impaired cerebrospinal fluid circulation, such as signs of obstructive hydrocephalus or mass effect?", "Is there a visible indication of increased intracranial pressure, such as compression of the brainstem or cerebellum?", "Can you identify features suggesting brainstem dysfunction due to mass effect from a tumor or hemorrhage?", "Does the image contain signs of disrupted coordination or cerebellar disorders, such as ataxia or cerebellitis?", "Is there evidence of trauma, such as skull fracture or epidural hematoma, that could decrease protection of neural structures?", "Can you see signs of compromised blood supply in the region supplied by the posterior circulation, such as findings consistent with a posterior circulation stroke?", "Does the image suggest balance impairment or vestibular dysfunction involving the cerebellum or vestibular nuclei?", "Is there evidence of cerebrospinal fluid outflow obstruction at the fourth ventricle or aqueduct, indicating impaired pressure buffering?", "Can you identify a mass lesion that may be compressing cranial nerve nuclei or roots?", "Does the image show features of respiratory dysfunction related to brainstem compression from a mass lesion or edema?", "Are there findings consistent with a congenital malformation, such as Dandy-Walker malformation, leading to impaired cerebrospinal fluid drainage?", "Is there evidence of cerebellar tonsil herniation through the foramen magnum, as seen in Chiari malformation?", "Can you see signs of infection, inflammation, or abscess formation that might alter neural connectivity in this region?", "Does the image reveal cerebellar atrophy with associated impairment of motor coordination?", "Is there evidence of acute hemorrhage affecting the brainstem or surrounding structures, potentially leading to autonomic dysfunction?"], "functions": ["Does the image show a region that houses and protects both the cerebellum and the brainstem?", "Is there an area providing structural support and space for the brainstem and its neural pathways?", "Can you identify a region that enables movement coordination by containing the cerebellum?", "Does the image include a space involved in balance and posture through processing vestibular and proprioceptive information?", "Is there a region that contains multiple cranial nerve nuclei responsible for sensory and motor functions of the head and neck?", "Can you see an area that allows communication between the brain and spinal cord by accommodating major ascending and descending neural tracts?", "Is there a structure involved in regulating vital autonomic functions such as respiration and cardiovascular control?", "Does the image show a region participating in sensory and motor signal integration through the inclusion of the cerebellum and brainstem nuclei?", "Can you identify an area that maintains cerebrospinal fluid flow by containing the fourth ventricle and related cisterns?", "Is there a region contributing to reflex control by housing neural circuits involved in cranial and spinal reflexes?"]}, "no_questions": {"contexual_properties": ["Is there a region where a bundle appears to have increased mass, possibly due to hypertrophy or hyperplasia?", "Is there a bundle of cells that appears thicker than others, potentially reflecting hypertrophy or increased workload?", "Does the image show a loss of normal organization within a bundle, which could be due to neoplastic transformation or severe injury?"], "properties": ["Does the image show a structure that is elongated and fusiform in shape?", "Is there evidence of protein expression such as smooth muscle actin, desmin, or caldesmon in the image?", "Does the image contain a bundle of cells with high density and minimal extracellular space?"], "relational": ["Does the image show a tissue layer that could be part of the muscularis mucosae or tunica media?", "Can you identify a region within the gastrointestinal tract, uterus, urinary bladder, bronchi, or blood vessels that appears to be composed of organized bundles of cells?", "Does the image show bundles of cells surrounded by endomysium, perimysium, or loose connective tissue?"], "contexual_behavior": ["Is there a feature that might display reduced contractility in the presence of myopathies or chronic inflammation?", "Is there a region that might alter its contraction or relaxation patterns during electrolyte imbalances such as hypokalemia or hypercalcemia?", "Can you see a structure that might exhibit irregular or diminished contractions in response to inflammation?"], "functions": ["Is there a feature that could regulate the diameter of blood vessels, thereby controlling vascular resistance?", "Does the image contain a structure capable of generating strong, coordinated contractions to assist with the expulsion of contents from organs like the bladder or uterus?", "Is there a region that appears to provide constant, low-level contraction to support organ structure and maintain tone?"]}}, "meningioma": {"yes_questions": {"contexual_properties": ["Does the image show a mass that appears larger, suggesting active cell proliferation or the influence of growth factors?", "Is there evidence of a lesion that has decreased in size, possibly indicating a response to treatment such as surgery or radiotherapy?", "Can you identify an area with altered density that might reflect calcification, cystic degeneration, or hemorrhage within a tumor?", "Is there a structure that appears calcified, suggesting chronicity or maturation of a lesion?", "Does the image reveal cystic regions within a mass, possibly due to necrosis or degeneration?", "Is there a lesion with prominent blood vessels or increased vascularity, which could indicate angiogenesis or a higher-grade tumor?", "Can you observe changes in the texture of a mass, such as areas of fibrosis, calcification, or cystic transformation?", "Is there a region within a lesion that appears necrotic, possibly due to insufficient blood supply or high tumor grade?", "Does the image show color changes in a mass that might be due to hemorrhage, necrosis, or increased vascularity?", "Is there evidence that a mass is invading surrounding tissue, which could suggest atypical or malignant transformation?", "Can you see a lesion with increased cellularity, possibly associated with rapid growth or a higher tumor grade?", "Does the image display signs of hemorrhage within a mass, potentially due to fragile vessels or a high-grade tumor?", "Is there visible swelling or edema around a lesion, suggesting peritumoral brain edema from mass effect or increased vascular permeability?", "Can you identify features that might indicate atypical or malignant transformation, such as increased mitotic activity or invasion into adjacent structures?", "Does the image show a mass with increased mitotic figures, suggesting aggressive growth or a higher-grade variant?", "Is there evidence of histological changes within a lesion, such as areas of necrosis, calcification, or increased cellularity?", "Can you observe peritumoral edema, possibly resulting from blood-brain barrier disruption or compression of adjacent brain tissue?", "Is there involvement of adjacent cranial bones, such as hyperostosis or invasion, associated with a nearby mass?", "Does the lesion appear to have changed its growth rate, which could be due to hormonal influences, genetic mutations, or recent therapy?", "Is there a region that shows contrast enhancement on imaging, possibly indicating blood-brain barrier disruption or increased vascularity?"], "properties": ["Is there a mass in the image that measures from a few millimeters up to several centimeters in diameter?", "Can you identify a structure whose weight could range from a few grams to several tens of grams depending on its size?", "Does the image show a lesion that appears round or lobulated in shape?", "Is there a mass with a grayish, tan, or yellowish coloration visible?", "Can you see a structure that could be composed of meningothelial, fibroblastic, or transitional cell types?", "Is there evidence of a lesion with a low mitotic index, such as less than 4 mitoses per 10 high-power fields?", "Does the image show a mass with a density that appears firmer or more rubbery than surrounding brain tissue?", "Is there a structure that might have a lower water content than normal brain tissue, around 70%?", "Can you identify a lesion that could express proteins such as EMA, vimentin, or progesterone receptor?", "Is there a mass that may be associated with genetic alterations like NF2 gene loss or changes in TRAF7, KLF4, or AKT1?", "Does the image show a lesion with a low Ki-67 labeling index, typically less than 5%?", "Is there evidence of a highly vascularized mass with a rich capillary network?", "Can you see areas of calcification, possibly appearing as psammoma bodies within a lesion?", "Is there a structure that may express progesterone receptors and occasionally estrogen receptors?", "Does the image show a mass with a firm and rubbery texture?", "Is there a lesion that appears to have low lipid content?", "Can you identify a structure with abundant collagen, especially if it appears fibrous?", "Is there evidence suggesting chromosomal abnormalities such as monosomy 22 or losses on chromosomes 1p and 14q in a visible mass?", "Does the image show a lesion that appears to have a slow growth rate, possibly with doubling times measured in years?", "Is there a mass with a low percentage of necrosis, typically less than 5%?"], "relational": ["Is there an abnormality affecting the central nervous system visible in the image?", "Can you identify a lesion adjacent to the brain or cranial nerves?", "Does the image show a mass near the skull?", "Is there evidence of a structure originating from the arachnoid mater?", "Can you see a lesion located in the cerebral hemispheres, spinal cord, or cranial base?", "Does the image reveal involvement of membranes such as the meninges, specifically the arachnoid or dura mater?", "Is there a mass associated with blood vessels like the middle meningeal artery or dural venous sinuses?", "Can you identify a lesion in proximity to cranial nerves such as the optic, trigeminal, or oculomotor nerve?", "Does the image show a mass near bones of the skull, such as the sphenoid, frontal, or temporal bone?", "Is there a structure closely related to the arachnoid layer of the meninges?", "Can you see a lesion affecting the supratentorial, infratentorial, or spinal compartments of the brain?"], "contexual_behavior": ["Does the image show a mass that could cause compression of adjacent neural tissue, potentially leading to neurological impairment?", "Is there evidence of a lesion that might obstruct cerebrospinal fluid flow and result in hydrocephalus?", "Can you identify a tumor that appears to induce swelling in surrounding brain tissue, suggesting increased vascular permeability and peritumoral edema?", "Is there a structure whose proximity to cranial nerves could explain impairment of cranial nerve function?", "Does the image reveal features consistent with rapid expansion of a mass, possibly causing sudden neurological deficits?", "Can you see signs of a tumor that might display increased angiogenesis, such as prominent blood vessels, possibly in response to local hypoxia?", "Is there evidence of a lesion that could be more invasive or high-grade, suggesting malignant transformation?", "Does the image suggest the presence of a mass that might have undergone regression or reduction in size, potentially after radiation therapy?", "Can you identify a tumor that appears to have reduced in size or secretory activity, possibly following surgical resection?", "Is there a lesion that could show decreased growth or mitotic activity, perhaps as a result of chemotherapy?", "Does the image suggest a mass with altered vascular supply, potentially due to anti-angiogenic therapy?", "Can you see evidence of local inflammation or immune cell infiltration around a recurrent tumor?", "Is there a structure that might display features of extracellular matrix remodeling, such as irregular borders, indicating tumor progression?", "Does the image show a mass whose growth rate might be reduced in an elderly patient, possibly due to cellular senescence?", "Can you identify a lesion that could be associated with increased secretion of growth factors, suggesting an aggressive subtype?", "Is there a tumor that might exhibit altered immune evasion mechanisms, particularly in an immunocompromised patient?", "Does the image suggest a mass with metabolic changes that could occur under hypoxic conditions?", "Is there evidence of a lesion whose proliferative activity might be influenced by hormonal status, such as periods of elevated estrogen or progesterone?", "Can you see signs of a tumor that might display decreased hormone receptor activity, possibly in a postmenopausal patient?", "Is there a mass that could show reduced proliferative capacity after targeted molecular therapy?"], "functions": ["Is there a mass in the image that appears to be growing slowly and invading nearby tissue?", "Can you identify a lesion that is causing compression of adjacent brain regions?", "Does the image show evidence of increased intracranial pressure or a space-occupying effect within the cranial vault?", "Is there a structure exerting pressure on functional areas of the brain, potentially leading to focal neurological symptoms?", "Can you see any indication of obstructed cerebrospinal fluid pathways or signs suggestive of hydrocephalus?", "Is there a region where the blood-brain barrier might be disrupted, possibly indicated by increased permeability?", "Does the image reveal reduced local cerebral blood flow or compression of blood vessels near a mass?", "Is there evidence of mass effect, edema, or irritation of neural tissue in the vicinity of a lesion?", "Can you identify signs of local inflammation, such as immune cell infiltration, around a mass?", "Is there a structure compressing or invading cranial nerve pathways, potentially impairing nerve function?", "Does the image suggest altered brain physiology, such as changes in electrical activity or metabolism, near a lesion?", "Is there a mass located near endocrine structures that could be affecting hormone secretion by compressing the pituitary gland or hypothalamus?", "Can you see features that might explain seizures or other neurological disturbances due to irritation or disruption of cortical tissue?"]}, "no_questions": {"contexual_properties": ["Does the left side show signs of reduced blood flow, possibly due to partial obstruction or distal ischemia?", "Does the left side show any evidence of increased diameter, as might be seen in aneurysmal dilation or compensatory enlargement?", "Can you identify any calcification on the left side, possibly resulting from chronic atherosclerosis or metabolic disorders?"], "properties": ["Does the image show a left-sided structure with a cross-sectional area between 3 and 12 mm\u00b2?", "Can you identify a left-sided vessel with a diameter in the range of 2 to 4 mm?", "Does the left side display a clear lumen with smooth walls and no evidence of obstruction?"], "relational": ["Does the image show anatomical boundaries such as the midline medially and the lateral thoracic wall laterally on one side?", "Are there connections to structures like the aortic arch, left brachiocephalic vein, or left bronchus on the left side?", "Is the left kidney or left atrium of the heart visible in the image?"], "contexual_behavior": ["Is there a left-sided structure where arterial flow appears unobstructed, indicating absence of an acute embolic event?", "Does the left side display vessel patency that is not compromised by low arterial pressure or hypoperfusion?", "Does the left region display vessel openness that could result from clot dissolution or thrombolytic therapy?"], "functions": ["Does the image suggest continuous physiological flow without blockage on the left side?", "Does the image show absence of obstruction or ischemia in tissues on the left side?", "Is there visual indication of adequate perfusion to tissues supplied by left-sided vessels?"]}}}
[ { "answer": "black and white dr garcia tumors b68", "extracted_concepts": [ "tumors" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "b68", "tumors" ], "question": "does this image show black and white dr garcia tumors b68?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "clivus" ], "question": "is bone, clivus present?" }, { "answer": "chordoma", "extracted_concepts": [ "chordoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "chordoma" ], "question": "is chordoma present?" }, { "answer": "bone, clivus", "extracted_concepts": [ "bone", "clivus" ], "question": "what is present?" }, { "answer": "chordoma", "extracted_concepts": [ "chordoma" ], "question": "what is present?" } ]	["chordoma", "bone", "tumors", "b68", "clivus"]	{"chordoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a lesion originating from embryonic tissue remnants, such as the notochord?", "Does the image show an abnormality located in the sacrum, clivus, or cervical spine?", "Can you identify a mass involving the vertebral bodies or the vertebral column?", "Is there evidence of a lesion affecting the nervous system or musculoskeletal system?", "Does the image reveal a mass adjacent to the brainstem, cranial nerves, or internal carotid arteries at the skull base?", "Can you see a structure whose anatomical boundaries are defined by bone margins, soft tissues, or nearby neural structures?", "Is there a lesion in proximity to cranial nerves, spinal nerves, or major blood vessels such as the basilar artery?", "Does the image contain a mass within the cranial cavity, spinal canal, or pelvic cavity?", "Can you identify an abnormality surrounded by bone, dura mater, muscle, or connective tissue at its primary site?"], "contexual_behavior": ["Is there evidence of a tumor exhibiting invasive behavior into surrounding tissues, potentially influenced by matrix metalloproteinases?", "Does the image show a lesion with features suggestive of accelerated growth that could be associated with hypoxic conditions or increased hypoxia-inducible factors?", "Can you identify a tumor that might display reduced responsiveness to radiotherapy, possibly due to upregulated DNA repair mechanisms or the presence of radioresistant cells?", "Is there a neoplastic area that appears resistant to chemotherapy, which could be linked to impaired apoptosis or overexpression of anti-apoptotic proteins like Bcl-2?", "Does the image suggest a recurrent tumor with altered metabolic activity, such as increased glycolytic flux or adaptation to metabolic stress?", "Can you observe increased blood vessel formation in association with a mass, possibly due to angiogenic factors like VEGF or FGF?", "Is there a tumor that appears to have decreased proliferation following targeted therapy aimed at signaling pathways such as PDGFR or EGFR?", "Does the image show a neoplasm that may be evading immune surveillance, potentially through the expression of immune checkpoint molecules like PD-L1?", "Is there evidence of a mass with enhanced metastatic potential, possibly related to advanced disease or features of epithelial-mesenchymal transition?", "Can you identify a tumor that shows reduced extracellular matrix degradation in areas that might correspond to low-nutrient environments?", "Does the lesion appear to be influenced by inflammatory processes, such as activation of NF-\u03baB or cytokine-mediated responses?", "Is there evidence of increased secretion of immunosuppressive factors, such as TGF-\u03b2 or IL-10, within the tumor microenvironment?", "Can you see signs of decreased cell cycle progression in a tumor, possibly as a result of DNA damage and activation of cell cycle checkpoints like p53?", "Is there a neoplastic region that appears to lack normal cell differentiation, which could be due to dysregulation of key transcription factors?", "Does the tumor show features suggesting increased survival under oxidative stress, such as upregulation of antioxidant defenses like glutathione peroxidase?"], "functions": ["Does the image show a lesion with evidence of slow growth or local recurrence?", "Can you identify a mass that appears to invade or compress surrounding tissues, leading to structural disruption?", "Is there visual evidence of bone erosion or destruction adjacent to a mass, suggesting osteolytic activity?", "Does the image reveal a structure infiltrating nearby anatomical regions or degrading the extracellular matrix?", "Can you see a mass that may be evading immune detection, such as by lacking typical antigen presentation features?", "Is there a lesion that demonstrates signs of sustained proliferation, resistance to cell death, or new blood vessel formation?", "Does the image suggest alteration of normal cellular signaling pathways, such as those involving PI3K/AKT or EGFR?", "Can you observe compression or instability affecting the spine or skull base, possibly leading to neurological deficits?", "Is there evidence of a mass with features of cell migration or invasion, indicating potential for distant dissemination?", "Does the image show changes in local blood supply, such as neovascularization or compression of existing vessels near a lesion?", "Can you identify disruption of normal bone remodeling, such as increased osteoclast activity or inhibited bone formation?", "Is there a mass that appears to promote its own growth and survival through autocrine signaling or growth factor production?", "Does the image suggest dysregulation of cell cycle control, altered apoptosis, or impaired differentiation within a lesion?", "Can you see signs of local inflammation, such as recruitment of inflammatory cells or release of pro-inflammatory cytokines, in the tissue surrounding a mass?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure that could impact the skeletal or lymphatic systems due to disease progression?", "Are there signs of invasion into the seminal vesicles, bladder neck, rectum, or neurovascular bundles?", "Is there any indication of involvement of the transitional or central zones within the gland?"], "contexual_behavior": [], "functions": []}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Does the image show a neck region with increased width that could be associated with congenital anomalies or lymphatic malformations?", "Are there signs of fibrotic changes in the neck that could be due to chronic inflammation or previous surgical procedures?", "Can you observe a change in the length of the neck region that might be related to growth or surgical reconstruction?"], "properties": ["Is there an indication of increased or abnormally distributed collagen in the skin of the neck folds?", "Can you observe skin in the neck area that appears smooth but may also look redundant or slightly wrinkled?", "Does the region between the mastoid process and the acromion show a continuous web-like extension?"], "relational": ["Is there a feature in the neck region that could be associated with Turner syndrome or Noonan syndrome?", "Are the superficial or posterior cervical lymph nodes visible or displaced in the neck?", "Are the clavicles or cervical vertebrae associated with an unusual tissue extension in the neck?"], "contexual_behavior": ["Is there visible tightness or restriction in the neck region that could exacerbate functional limitations during puberty or periods of rapid growth?", "Can you see thickened tissue in the neck that could compress superficial veins or arteries and potentially alter blood flow during exercise?", "Does the lateral aspect of the neck appear to have folds that might limit extension, rotation, or flexion during physical activity?"], "functions": ["Does the image show evidence of limited neck mobility, such as restricted range of motion or visible skin folds?", "Can you observe features that might indicate impaired lymphatic drainage, such as localized swelling suggestive of lymphedema?", "Is there a visible abnormality in head or neck posture, such as a forward head position, that could be due to restricted soft tissue mobility?"]}}, "tumors": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to be increasing in size, suggesting active cell division or growth?", "Can you identify an area that seems to have decreased in size, possibly indicating a response to therapy or immune activity?", "Does the image show a region with altered coloration that could be due to changes in blood supply, necrosis, or hemorrhage?", "Is there evidence of increased vascularization in any structure, which might suggest angiogenesis stimulated by growth factors?", "Can you see a region that appears necrotic, possibly due to insufficient blood supply or rapid expansion?", "Is there a visible area with calcifications, which could result from chronic necrosis or degeneration?", "Does the image show a structure with cystic features, such as central degeneration or fluid accumulation?", "Can you identify a region with variable density, possibly reflecting differences in cellularity, fibrosis, necrosis, or calcification?", "Is there an area that appears firmer or denser, which might be due to increased fibrosis or a desmoplastic reaction?", "Do you see a region that looks softened, perhaps as a result of necrosis, liquefaction, or cyst formation?", "Is there evidence of increased cellularity in any structure, which could indicate rapid proliferation or a high-grade lesion?", "Does any area display irregular borders, suggesting invasion into surrounding tissues or loss of encapsulation?", "Can you identify a region with mixed composition, such as areas of necrosis, hemorrhage, fibrosis, or cystic change?", "Is there a structure that appears hypermetabolic, possibly due to rapid growth or malignant transformation?", "Do you see a surface defect or ulceration, which might result from outgrowing the blood supply or invasion of overlying tissue?", "Is there evidence of hemorrhage within a structure, possibly due to fragile new blood vessels or vascular invasion?", "Can you observe any changes that might correspond to fluctuations in marker levels, such as progression, recurrence, or response to treatment?", "Does any region appear more heterogeneous, potentially due to genetic mutations, necrosis, or hemorrhage?", "Is there a structure that seems to have lost its capsule and is infiltrating adjacent tissues, indicating invasive behavior?", "Do you see signs of edema, such as swelling or fluid accumulation, which could result from disrupted vasculature or inflammation?"], "properties": ["Is there a mass in the image whose size appears variable, ranging from a few millimeters to several centimeters?", "Can you identify a structure that could weigh anywhere from less than a gram to several kilograms, depending on its characteristics?", "Does the image show a mass with an irregular, nodular, or spherical shape?", "Is there an area that appears pale, gray, white, red, or yellow in color, possibly reflecting differences in vascularity or necrosis?", "Can you see a structure that looks firm, hard, soft, or gelatinous in consistency?", "Is there a mass that might be composed of neoplastic, stromal, inflammatory, or endothelial cells?", "Does the image suggest a region where cell division is elevated compared to surrounding tissue?", "Is there evidence of a structure that could be growing more rapidly than the adjacent normal tissue?", "Can you identify an area with increased or heterogeneous vascularity, possibly due to angiogenesis?", "Does the image show a region that might contain significant necrotic content, especially in rapidly growing or poorly vascularized areas?", "Is there a mass with density higher than that of the surrounding tissue, or with variable density depending on its composition?", "Can you see a structure that might have a high water content, similar to or slightly less than normal tissue?", "Is there an area that could be associated with altered protein expression, such as overexpression or loss of markers like Ki-67, p53, or HER2?", "Does the image suggest the presence of cells with abnormal DNA content, such as aneuploidy or increased DNA replication?", "Is there a region that could have a lower pH, possibly between 6.5 and 7.0, due to increased glycolysis?", "Can you identify an area that might be hypoxic, with reduced oxygen concentration compared to normal tissue?", "Does the image show a region where glucose uptake or concentration might be elevated?", "Is there a mass that could have increased lipid content, particularly if it resembles tissue types like liposarcoma?", "Can you see evidence of high cellular atypia, such as pleomorphism or abnormal cell morphology?", "Is there a region where the nuclear-to-cytoplasmic ratio appears increased, indicating larger nuclei relative to cytoplasm?"], "relational": ["Does the image show an abnormal mass originating from epithelial, connective, muscle, or nervous tissue?", "Can you identify a lesion present within the lung, liver, breast, colon, or brain?", "Is there a structure that could impact the nervous, respiratory, digestive, or endocrine system?", "Does the image display a mass adjacent to blood vessels, nerves, lymph nodes, or other organs?", "Can you see a region containing neoplastic, stromal, immune, or endothelial cells?", "Is there evidence of arterioles, capillaries, venules, or newly formed blood vessels supplying a mass?", "Does the image show lymphatic vessels, regional lymph nodes, or lymphatic capillaries interacting with a suspicious structure?", "Is there an abnormality located in the head and neck, thorax, abdomen, pelvis, or extremities?", "Can you observe a mass interacting with surrounding connective tissue, possibly through invasion or tissue remodeling?", "Is there a structure that appears to cross anatomical barriers such as the basement membrane, blood-brain barrier, serosal membranes, or fascia?"], "contexual_behavior": ["Is there a structure in the image that appears to have increased blood vessel formation, possibly indicating enhanced angiogenesis?", "Can you identify an area that might be resisting immune cell infiltration or showing signs of immune evasion?", "Does the image show a region where cells could be adapting to low oxygen by increasing glycolytic activity?", "Is there evidence of a mass that might be less responsive to chemotherapy, suggesting drug resistance?", "Can you see a structure that appears to be invading surrounding tissues, possibly in response to inflammation?", "Is there a mass that seems to be disrupting the normal architecture of nearby tissue, potentially suppressing local function?", "Does the image show a region where growth rate appears reduced, possibly due to nutrient deprivation or metabolic adaptation?", "Can you identify an area where cells might be avoiding programmed cell death, suggesting evasion of apoptosis?", "Is there a mass that appears to have decreased proliferation, possibly following radiation therapy?", "Does the image show a region that could be secreting immunosuppressive factors, as indicated by reduced immune cell presence nearby?", "Is there evidence of altered cell adhesion or motility in response to hormonal influence, possibly affecting metastatic potential?", "Can you see a mass that is compressing or infiltrating adjacent organs, potentially causing dysfunction due to mass effect?", "Is there a region where increased glycolysis might be occurring in response to low oxygen levels?", "Does the image show an area where antigen presentation to immune cells may be reduced, possibly due to downregulation of MHC molecules?", "Can you identify a structure that might be adapting its behavior in response to targeted therapy, such as by activating alternative signaling pathways?", "Is there evidence of increased production of growth factors to support proliferation and new blood vessel formation?", "Does the image show a mass with reduced growth, possibly following anti-angiogenic treatment and decreased vascular supply?", "Can you see a region that appears to be recruiting stromal cells, as indicated by increased presence of supporting cell types?", "Is there evidence of impaired cell cycle regulation, possibly due to genetic mutations affecting regulatory genes?", "Does the image show a structure that might be resisting oxidative stress, as suggested by features indicating upregulated antioxidant defenses?"], "functions": ["Does the image show a region where cell growth appears uncontrolled or excessive compared to surrounding tissue?", "Can you identify an area that seems to invade or disrupt the normal architecture of adjacent structures?", "Is there evidence of a mass compressing nearby anatomical features or altering organ performance?", "Does the image reveal a structure that could be dysregulating the cell cycle or promoting genetic instability?", "Can you see a region where abnormal cell proliferation might be driven by sustained mitogenic signaling?", "Is there a visible area that could be evading immune detection, such as by lacking typical antigen presentation markers?", "Does the image show evidence of new blood vessel formation, possibly due to secretion of vascular endothelial growth factors?", "Can you identify a structure that appears to degrade the extracellular matrix or invade surrounding tissues?", "Is there a region that might be entering blood or lymphatic vessels, suggesting potential for metastasis?", "Does the image display features consistent with increased glycolysis or altered metabolic activity in a localized area?", "Can you see a structure that seems resistant to programmed cell death, such as by persisting despite cellular stress or damage?", "Is there evidence of recruitment or activation of stromal cells in the vicinity of an abnormal mass?", "Does the image show signs of chronic inflammation, such as accumulation of inflammatory cells near a suspicious area?", "Can you identify a region that might be producing ectopic hormones or disrupting normal endocrine feedback?", "Is there a visible interaction between an abnormal structure and immune or stromal cells, such as recruitment of fibroblasts or macrophages?", "Does the image reveal obstruction of ducts or vessels, tissue necrosis, or impairment of physiological processes in association with a mass?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a lesion with very low or absent necrosis, less than 5% of its area?", "Does the image show a mass with a low mitotic index, typically less than 5 mitoses per 10 high power fields?", "Is there a structure that likely expresses estrogen and progesterone receptors?"], "relational": ["Is there an abnormality adjacent to the vagina, bladder, or rectum?", "Does the image contain a mass composed of smooth muscle and connective tissue?", "Is there a structure located within the cervical region of the uterus?"], "contexual_behavior": [], "functions": ["Can you identify any narrowing or blockage of the cervical canal that could impede the normal passage of menstrual blood?", "Does the image show any features that might explain abnormal uterine bleeding, such as menorrhagia?", "Can you identify a structure that could impair normal uterine contractility?"]}}, "b68": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears enlarged, possibly due to inflammation or neoplastic growth?", "Can you identify an object that seems reduced in size, which might suggest atrophy or degeneration?", "Does any area show a change in color that could indicate hemorrhage, ischemia, or pigment deposition?", "Is there a structure that appears heavier or denser, potentially from fluid accumulation or calcification?", "Can you see a region that looks lighter, possibly as a result of tissue loss or necrosis?", "Is there evidence of altered composition, such as fibrosis or infiltration by abnormal cells, within any structure?", "Do you observe any accumulation of abnormal substances, such as fat or iron, in a particular area?", "Is there a swollen region that could be due to acute inflammation, infection, or trauma?", "Can you spot a structure that appears shrunken, which might be associated with chronic disease or disuse?", "Does any area display an abnormal texture, such as firmness from fibrosis or irregularity from tumor infiltration?", "Is there a region with increased measurable properties, possibly reflecting hyperfunction or neoplastic activity?", "Can you identify a structure with decreased measurable levels, which could result from hypofunction or tissue loss?", "Do you see any discoloration that might be caused by hemorrhage, necrosis, or pigment deposition?", "Is there a change in density within a structure, such as increased density from calcification or decreased density from tissue loss?", "Can you observe abnormal structural features, like those seen in congenital malformations, neoplasms, or scarring?", "Does any area show changes in measurable properties that could be related to inflammation, infection, or malignancy?", "Is there a region that appears more rigid, possibly due to fibrosis or chronic inflammation?", "Can you identify a softer area that might result from edema, necrosis, or liquefactive processes?", "Do you notice any abnormal surface appearances, such as ulceration, nodularity, or exudate formation?", "Is there evidence of cellular changes, such as those seen in dysplasia, metaplasia, or neoplastic transformation, within any structure?"], "properties": ["Is there a structure in the image whose size cannot be determined based on current biomedical knowledge?", "Can you identify an object whose weight is not established in anatomical references?", "Does the image contain a feature whose typical color is not defined in biomedical ontologies?", "Is there a structure present whose shape is not described in anatomical literature?", "Can you see an object whose texture remains unspecified in biomedical sources?", "Is there a region whose average volume cannot be provided due to lack of information?", "Does the image show something whose chemical composition is unknown in biomedical contexts?", "Is there a structure whose density is not documented in scientific references?", "Can you identify an area whose normal pH is not established in biomedical data?", "Is there a feature whose water content is not reported in anatomical or physiological literature?", "Does the image include an object whose temperature is not defined in biomedical sources?", "Can you see a structure whose concentration of key molecules is unavailable due to insufficient information?", "Is there a region whose structural organization is not described in anatomical or histological references?", "Does the image contain a feature whose surface area is not specified in biomedical ontologies?", "Can you identify an object whose electrical conductivity is not documented in scientific literature?", "Is there a structure whose osmolarity is not established in biomedical references?", "Does the image show something whose lipid content is not reported in anatomical or physiological data?", "Can you see a region whose protein content is not defined in biomedical sources?", "Is there a structure whose carbohydrate content is not specified in scientific literature?", "Can you identify an object whose mineral content is unavailable due to lack of specific information?"], "relational": ["Does the image show an organ that is part of the urinary system and located in the abdominal cavity?", "Can you identify a structure adjacent to the spleen, pancreas, or left adrenal gland?", "Is there an object connected to both a renal artery and a ureter?", "Does the image contain a structure composed of a renal cortex, renal medulla, and renal pelvis?", "Can you see a feature associated with the left renal artery or left renal vein?", "Is there a structure whose boundaries are defined by perirenal fat and a renal capsule?", "Does the image show an object maintaining spatial relationships with the descending colon or diaphragm?", "Can you identify a structure containing renal pyramids, renal columns, or calyces?"], "contexual_behavior": ["Is there a structure in the image that appears more active or prominent in response to acute physiological or psychological stress?", "Can you identify an object that shows signs of impaired function or altered appearance in the context of chronic inflammation or organ dysfunction?", "Does the image reveal a structure that might fail to perform its normal role under severe infection or tissue damage?", "Is there evidence of impaired activity in a component that could be affected by pro-inflammatory mediators during inflammation?", "Can you see a structure whose appearance or features suggest adaptation to environmental changes such as temperature or nutrient levels?", "Does the image show an area that appears more active or involved in tissue repair and regeneration during recovery from injury?", "Is there a region that might exhibit reduced activity due to the presence of toxins inhibiting normal biochemical pathways?", "Can you identify a structure that appears to increase its metabolic contribution during fasting or altered energy states?", "Does the image show a component that might display diminished function in the context of chronic illness or long-term impairment?", "Is there a structure that appears to shift its activity during acute infection, possibly participating in immune defense or metabolic changes?", "Can you see an area that might be less effective under hypoxic conditions due to limited oxygen availability?", "Is there evidence of a protective role being enhanced in response to oxidative stress, such as activation of antioxidant mechanisms?", "Does the image reveal a structure that seems unable to adapt during rapid physiological changes, suggesting dysregulation?", "Can you identify a component that appears less efficient or altered in an aging organism, possibly due to cumulative cellular damage?", "Is there a region whose features suggest functional modulation in response to hormonal fluctuations or endocrine signaling?"], "functions": ["Does the image show a structure that facilitates essential physiological activities within the body?", "Is there an object present that supports or modulates key bodily operations?", "Can you identify a feature involved in maintaining homeostasis or balancing internal conditions?", "Does the image contain something that participates in regulating pathways or ensuring proper system responses?", "Is there a structure that supports metabolic, regulatory, or protective functions?", "Can you see an object that coordinates activities or facilitates communication between organs?", "Is there evidence of a feature involved in adaptation, signaling, or responding to physiological stimuli?", "Does the image include a structure that contributes to defense mechanisms or supports immune responses?", "Can you identify something that influences biochemical reactions or manages energy within the body?", "Is there an object that modulates gene expression, signaling pathways, or cellular responses?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image reveal any impact on the endothelium or smooth muscle within arterial walls?", "Can you identify any abnormalities in the marginal or diagonal branches of the coronary arteries?", "Can you identify any abnormalities in the left or right coronary arteries?"], "contexual_behavior": [], "functions": ["Does the image suggest a mismatch between coronary blood supply and the oxygen needs of the myocardium?", "Does the image show evidence of narrowed arteries that could restrict blood flow to the heart muscle?", "Are there visual cues indicating smooth muscle proliferation or increased extracellular matrix within the vessel wall?"]}}, "clivus": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure present that measures approximately 4 to 6 centimeters in length?", "Can you identify a region with a width of about 2 to 3 centimeters at its broadest point?", "Does the image show a bony area with a thickness of roughly 1 to 1.5 centimeters?", "Is there a sloping, concave bone visible in the cranial base?", "Can you see a structure whose bone density appears similar to other bones at the base of the skull, typically around 1.2 to 1.5 g/cm\u00b3?", "Is there an obliquely oriented bone running downward and backward from the dorsum sellae toward the foramen magnum?", "Does the image contain a structure forming an angle of about 120 to 135 degrees with the skull base?", "Can you identify a region composed of both cortical and cancellous bone tissue?", "Is there a bony surface that appears generally smooth?", "Can you see a bone with a pale yellow to light brown coloration, as seen in fresh specimens?", "Is there a structure with an estimated volume of 8 to 12 cubic centimeters?", "Does the image show a bone whose mineral content is primarily hydroxyapatite and calcium phosphate?", "Can you identify a gently curved bone with an anterior concavity?", "Is there evidence of a bone formed by endochondral ossification from the basioccipital and basisphenoid regions?", "Does the image show a cranial base structure that would typically complete fusion by late adolescence, around age 18?"], "relational": ["Does the image show a structure that is part of the cranial base?", "Can you identify a region that is adjacent to both the sphenoid bone and the occipital bone?", "Is there an area associated with the posterior cranial fossa?", "Can you see a structure that is centrally located at the base of the skull?", "Is there a region situated anterior to the foramen magnum and brainstem?", "Does the image include an area that is posterior to the sphenoid sinus and dorsum sellae?", "Can you identify a location near the hypoglossal canal or jugular foramen?", "Is there a structure closely related to the pons or medulla oblongata?", "Does the image show proximity to vascular structures such as the basilar artery or inferior petrosal sinus?", "Can you see a region that forms the posterior part of the sphenoid bone and the anterior part of the occipital bone, articulating with both?"], "contexual_behavior": ["Does the image show evidence of bone erosion or thinning at the cranial base that could reduce support for the brainstem?", "Can you identify any signs of instability or fracture at the base of the skull that might result from trauma?", "Is there visual evidence of bone destruction or displacement of tissues near neurovascular structures that could suggest tumor invasion?", "Does the image reveal decreased bone density or deformation in a cranial base structure that might indicate osteoporosis?", "Can you see any anatomical alterations or reduced stability in the cranial base region that could result from surgical resection?", "Is there any indication of compromised separation between the brain and nasopharynx, such as bone loss or abscess formation, that might suggest infection?", "Does the image display features consistent with congenital malformations like basilar invagination or hypoplasia affecting cranial base integrity?", "Can you observe deformation or displacement of a cranial base structure that could be related to increased intracranial pressure?", "Is there evidence of bone swelling or erosion at the cranial base that might be due to inflammatory conditions such as osteitis or granulomatous disease?", "Does the image show weakening of bone or displacement of adjacent neural structures in the cranial base region that could be caused by metastatic lesions?"], "functions": ["Does the image show a sloping bony surface that supports the brainstem?", "Can you identify a structure that contributes to the structural integrity of the cranial base?", "Is there a bony platform that prevents downward displacement of the brainstem?", "Does the image contain a feature that shields the pons and medulla oblongata from mechanical injury?", "Can you see a structure that connects the sphenoid and occipital bones, reinforcing the central skull base?", "Is there a midline element that helps maintain alignment between anterior and posterior cranial structures?", "Does the image show a region that forms part of the pathway for arteries, veins, or cranial nerves at the skull base?", "Can you identify a structure that separates the posterior cranial fossa from the upper cervical spinal canal, thereby demarcating neural compartments?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure positioned near the spleen or transverse colon?", "Can you see a lining that might contain parietal cells, chief cells, mucous cells, or enteroendocrine cells?", "Is there a structure that could be innervated by the vagus nerve or fibers from the celiac plexus?"], "contexual_behavior": [], "functions": ["Can you see an organ that mechanically breaks down food through muscular contractions?", "Can you identify a region where digestive enzymes like pepsinogen are secreted for protein breakdown?", "Does the image show a region where pepsin is activated to hydrolyze proteins?"]}}}
[ { "answer": "dr garcia tumors b6", "extracted_concepts": [ "b6", "tumors" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "b6", "tumors" ], "question": "does this image show dr garcia tumors b6?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "lymphoma", "extracted_concepts": [ "lymphoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "lymphoma" ], "question": "is lymphoma present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "lymphoma", "extracted_concepts": [ "lymphoma" ], "question": "what is present?" } ]	["lymphoma", "bone", "tumors", "b6", "calvarium"]	{"lymphoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a disease affecting the lymphatic or immune systems?", "Is there a region in the image where lymphoid tissue appears abnormal?", "Can you identify any structures that resemble enlarged lymph nodes?", "Does the image contain abnormalities in tissues such as bone marrow or spleen tissue?", "Is there a visible mass or abnormality in areas like the neck, chest, abdomen, groin, or mediastinum?", "Can you see any changes in the spleen or liver that might suggest involvement by a hematopoietic disorder?", "Does the image show signs of abnormal cell proliferation within lymphatic structures?", "Is there evidence of tissue enlargement or dysfunction in lymph nodes?", "Can you identify any features suggesting the presence of malignant lymphocytes or abnormal B, T, or NK cells?", "Does the image suggest spread of abnormal tissue along lymphatic vessels or into adjacent tissues?", "Are there visible interactions between affected lymphatic structures and the circulatory or endocrine systems?", "Can you see any anatomical changes in areas adjacent to blood vessels, nerves, muscles, or connective tissue that might indicate disease involvement?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a process characterized by uncontrolled cell growth and resistance to programmed cell death?", "Can you identify a region where normal lymphoid tissue appears to be replaced or disrupted, potentially impairing immune responses?", "Is there visual evidence of abnormal lymphocyte activity, such as signs of malignant transformation or functional dysregulation?", "Does the image reveal infiltration or destruction of lymph node architecture, possibly reducing filtration or immune surveillance?", "Can you detect features suggesting a reduction in effective immune cell populations or compromised immune responses?", "Is there any indication of bone marrow involvement that could suppress normal blood cell production?", "Does the image suggest altered cytokine production or disrupted communication between immune cells?", "Can you observe any obstruction of lymphatic vessels or signs of lymphedema that might indicate impaired lymphatic drainage?", "Is there evidence of cells that may evade immune detection, such as reduced antigen presentation or increased immunosuppressive activity?", "Can you identify features consistent with abnormal cell proliferation driven by genetic mutations or activation of oncogenic signaling pathways?", "Does the image suggest the presence of systemic effects, such as increased metabolic activity or inflammation, that could lead to symptoms like fever or weight loss?", "Is there visual evidence of overexpression of anti-apoptotic proteins or inhibition of cell death pathways in lymphoid tissues?", "Can you detect activation of signaling pathways such as NF-\u03baB, JAK/STAT, or PI3K/AKT in lymphocyte populations?", "Does the image indicate impaired B cell function or reduced antibody production?", "Are there signs of increased pro-inflammatory cytokine levels or chronic inflammation in the tissue?"]}, "no_questions": {"contexual_properties": ["Can you identify swollen organelles that might suggest cellular injury or osmotic imbalance?", "Does the image show increased lipid droplets that may be associated with steatosis or metabolic syndrome?", "Can you observe altered chromatin patterns that could be related to apoptosis or neoplastic transformation?"], "properties": ["Is it possible to estimate the number of bits used to represent each pixel in the image data?", "Can you determine if the average intensity of the image suggests a particular level of brightness adjustment?", "Can you assess whether the difference in intensity between features suggests influence from staining or imaging conditions?"], "relational": ["Can you observe anatomical relationships such as organelle proximity or membrane interactions?", "Can you see evidence that the sample was prepared as a thin tissue section, cultured cell, or isolated organelle?", "Can you determine if the sample includes molecular assemblies, organelles, whole cells, or tissue sections?"], "contexual_behavior": ["Is there any indication of sample damage or altered imaging function that could result from high electron beam intensity?", "Does the image show evidence of cellular ultrastructure loss that could result from sample preparation artifacts such as shrinkage or distortion?", "Can you see improved distinction of membrane structures that would be consistent with cryo-fixation preserving native ultrastructure?"], "functions": ["Does the image reveal molecular organization or features that could indicate pathological alterations?", "Is there visible tissue architecture or specialized structures that suggest assessment of cell-to-cell interactions?", "Does the image provide a high-resolution view that reveals ultrastructural details of biological material?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Is there any indication of trauma to the cervical spine, head, or neck muscles that could explain the observed posture?", "Is there visual evidence that physical therapy targeting muscle balance and postural control could be beneficial for the observed posture?", "Can you observe signs of muscle weakness, as might be seen in myasthenia gravis or following peripheral nerve injury?"], "properties": ["Can you observe a shift in head weight distribution toward one side, potentially increasing the load on neck muscles on that side?", "Is there a visible change in the distance between the ear and shoulder, measuring approximately 2 to 5 centimeters on one side?", "Does the image show an individual whose head forms an angle between 15 and 45 degrees from the vertical axis?"], "relational": ["Is there evidence of the occipital bone or upper cervical vertebrae supporting a shifted head position?", "Does the alignment of the vertebrae suggest movement at the atlanto-occipital joint?", "Does the image suggest involvement of the accessory nerve or cervical spinal nerves in controlling the head's posture?"], "contexual_behavior": ["Does the image include someone whose auditory function might be reduced due to altered eustachian tube drainage and increased middle ear pressure?", "Is there an individual whose airway patency during sleep could be improved by repositioning of the tongue and soft tissues?", "Is there an individual whose posture could facilitate sinus drainage by using gravity to enhance mucus clearance?"], "functions": ["Does the head position in the image appear likely to affect swallowing mechanics or airway patency?", "Can you identify a posture that might be used to compensate for sensory deficits by optimizing remaining sensory input?", "Is there an individual whose head position might influence balance or spatial orientation by changing the alignment of the vestibular apparatus?"]}}, "tumors": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to be increasing in size, suggesting active cell division or growth?", "Can you identify an area that seems to have decreased in size, possibly indicating a response to therapy or immune activity?", "Does the image show a region with altered coloration that could be due to changes in blood supply, necrosis, or hemorrhage?", "Is there evidence of increased vascularization in any structure, which might suggest angiogenesis stimulated by growth factors?", "Can you see a region that appears necrotic, possibly due to insufficient blood supply or rapid expansion?", "Is there a visible area with calcifications, which could result from chronic necrosis or degeneration?", "Does the image show a structure with cystic features, such as central degeneration or fluid accumulation?", "Can you identify a region with variable density, possibly reflecting differences in cellularity, fibrosis, necrosis, or calcification?", "Is there an area that appears firmer or denser, which might be due to increased fibrosis or a desmoplastic reaction?", "Do you see a region that looks softened, perhaps as a result of necrosis, liquefaction, or cyst formation?", "Is there evidence of increased cellularity in any structure, which could indicate rapid proliferation or a high-grade lesion?", "Does any area display irregular borders, suggesting invasion into surrounding tissues or loss of encapsulation?", "Can you identify a region with mixed composition, such as areas of necrosis, hemorrhage, fibrosis, or cystic change?", "Is there a structure that appears hypermetabolic, possibly due to rapid growth or malignant transformation?", "Do you see a surface defect or ulceration, which might result from outgrowing the blood supply or invasion of overlying tissue?", "Is there evidence of hemorrhage within a structure, possibly due to fragile new blood vessels or vascular invasion?", "Can you observe any changes that might correspond to fluctuations in marker levels, such as progression, recurrence, or response to treatment?", "Does any region appear more heterogeneous, potentially due to genetic mutations, necrosis, or hemorrhage?", "Is there a structure that seems to have lost its capsule and is infiltrating adjacent tissues, indicating invasive behavior?", "Do you see signs of edema, such as swelling or fluid accumulation, which could result from disrupted vasculature or inflammation?"], "properties": ["Is there a mass in the image whose size appears variable, ranging from a few millimeters to several centimeters?", "Can you identify a structure that could weigh anywhere from less than a gram to several kilograms, depending on its characteristics?", "Does the image show a mass with an irregular, nodular, or spherical shape?", "Is there an area that appears pale, gray, white, red, or yellow in color, possibly reflecting differences in vascularity or necrosis?", "Can you see a structure that looks firm, hard, soft, or gelatinous in consistency?", "Is there a mass that might be composed of neoplastic, stromal, inflammatory, or endothelial cells?", "Does the image suggest a region where cell division is elevated compared to surrounding tissue?", "Is there evidence of a structure that could be growing more rapidly than the adjacent normal tissue?", "Can you identify an area with increased or heterogeneous vascularity, possibly due to angiogenesis?", "Does the image show a region that might contain significant necrotic content, especially in rapidly growing or poorly vascularized areas?", "Is there a mass with density higher than that of the surrounding tissue, or with variable density depending on its composition?", "Can you see a structure that might have a high water content, similar to or slightly less than normal tissue?", "Is there an area that could be associated with altered protein expression, such as overexpression or loss of markers like Ki-67, p53, or HER2?", "Does the image suggest the presence of cells with abnormal DNA content, such as aneuploidy or increased DNA replication?", "Is there a region that could have a lower pH, possibly between 6.5 and 7.0, due to increased glycolysis?", "Can you identify an area that might be hypoxic, with reduced oxygen concentration compared to normal tissue?", "Does the image show a region where glucose uptake or concentration might be elevated?", "Is there a mass that could have increased lipid content, particularly if it resembles tissue types like liposarcoma?", "Can you see evidence of high cellular atypia, such as pleomorphism or abnormal cell morphology?", "Is there a region where the nuclear-to-cytoplasmic ratio appears increased, indicating larger nuclei relative to cytoplasm?"], "relational": ["Does the image show an abnormal mass originating from epithelial, connective, muscle, or nervous tissue?", "Can you identify a lesion present within the lung, liver, breast, colon, or brain?", "Is there a structure that could impact the nervous, respiratory, digestive, or endocrine system?", "Does the image display a mass adjacent to blood vessels, nerves, lymph nodes, or other organs?", "Can you see a region containing neoplastic, stromal, immune, or endothelial cells?", "Is there evidence of arterioles, capillaries, venules, or newly formed blood vessels supplying a mass?", "Does the image show lymphatic vessels, regional lymph nodes, or lymphatic capillaries interacting with a suspicious structure?", "Is there an abnormality located in the head and neck, thorax, abdomen, pelvis, or extremities?", "Can you observe a mass interacting with surrounding connective tissue, possibly through invasion or tissue remodeling?", "Is there a structure that appears to cross anatomical barriers such as the basement membrane, blood-brain barrier, serosal membranes, or fascia?"], "contexual_behavior": ["Is there a structure in the image that appears to have increased blood vessel formation, possibly indicating enhanced angiogenesis?", "Can you identify an area that might be resisting immune cell infiltration or showing signs of immune evasion?", "Does the image show a region where cells could be adapting to low oxygen by increasing glycolytic activity?", "Is there evidence of a mass that might be less responsive to chemotherapy, suggesting drug resistance?", "Can you see a structure that appears to be invading surrounding tissues, possibly in response to inflammation?", "Is there a mass that seems to be disrupting the normal architecture of nearby tissue, potentially suppressing local function?", "Does the image show a region where growth rate appears reduced, possibly due to nutrient deprivation or metabolic adaptation?", "Can you identify an area where cells might be avoiding programmed cell death, suggesting evasion of apoptosis?", "Is there a mass that appears to have decreased proliferation, possibly following radiation therapy?", "Does the image show a region that could be secreting immunosuppressive factors, as indicated by reduced immune cell presence nearby?", "Is there evidence of altered cell adhesion or motility in response to hormonal influence, possibly affecting metastatic potential?", "Can you see a mass that is compressing or infiltrating adjacent organs, potentially causing dysfunction due to mass effect?", "Is there a region where increased glycolysis might be occurring in response to low oxygen levels?", "Does the image show an area where antigen presentation to immune cells may be reduced, possibly due to downregulation of MHC molecules?", "Can you identify a structure that might be adapting its behavior in response to targeted therapy, such as by activating alternative signaling pathways?", "Is there evidence of increased production of growth factors to support proliferation and new blood vessel formation?", "Does the image show a mass with reduced growth, possibly following anti-angiogenic treatment and decreased vascular supply?", "Can you see a region that appears to be recruiting stromal cells, as indicated by increased presence of supporting cell types?", "Is there evidence of impaired cell cycle regulation, possibly due to genetic mutations affecting regulatory genes?", "Does the image show a structure that might be resisting oxidative stress, as suggested by features indicating upregulated antioxidant defenses?"], "functions": ["Does the image show a region where cell growth appears uncontrolled or excessive compared to surrounding tissue?", "Can you identify an area that seems to invade or disrupt the normal architecture of adjacent structures?", "Is there evidence of a mass compressing nearby anatomical features or altering organ performance?", "Does the image reveal a structure that could be dysregulating the cell cycle or promoting genetic instability?", "Can you see a region where abnormal cell proliferation might be driven by sustained mitogenic signaling?", "Is there a visible area that could be evading immune detection, such as by lacking typical antigen presentation markers?", "Does the image show evidence of new blood vessel formation, possibly due to secretion of vascular endothelial growth factors?", "Can you identify a structure that appears to degrade the extracellular matrix or invade surrounding tissues?", "Is there a region that might be entering blood or lymphatic vessels, suggesting potential for metastasis?", "Does the image display features consistent with increased glycolysis or altered metabolic activity in a localized area?", "Can you see a structure that seems resistant to programmed cell death, such as by persisting despite cellular stress or damage?", "Is there evidence of recruitment or activation of stromal cells in the vicinity of an abnormal mass?", "Does the image show signs of chronic inflammation, such as accumulation of inflammatory cells near a suspicious area?", "Can you identify a region that might be producing ectopic hormones or disrupting normal endocrine feedback?", "Is there a visible interaction between an abnormal structure and immune or stromal cells, such as recruitment of fibroblasts or macrophages?", "Does the image reveal obstruction of ducts or vessels, tissue necrosis, or impairment of physiological processes in association with a mass?"]}, "no_questions": {"contexual_properties": ["Do you see any signs of edema that could be related to cardiac failure or lymphatic obstruction?", "Are cystic structures present that might be associated with genetic syndromes or developmental anomalies?", "Can you infer abnormal cell counts from features such as pallor or petechiae, which might indicate hematologic disorders or bone marrow dysfunction?"], "properties": ["Does the image contain a structure whose brain volume could increase from less than 1 cm\u00b3 to several hundred cm\u00b3 as it matures?", "Does the image show a structure with a crown-rump length that could be used to estimate its developmental stage?", "Is there an object that likely has a high water content, possibly around 85\u201390% in early stages and decreasing as it matures?"], "relational": ["Is the central structure located within a cavity like the amniotic or chorionic cavity?", "Can you see a structure that is physically or functionally associated with the placenta for nutrient or gas exchange?", "Are there prominent features in the head region, neural tube, or heart primordium visible in the image?"], "contexual_behavior": ["Does the image show signs of decreased nutrient uptake that might result from placental dysfunction, especially in mid to late pregnancy?", "Can you identify features of impaired bone mineralization that might be due to vitamin D deficiency during periods of rapid skeletal growth?", "Can you observe signs of reduced waste elimination that might be due to placental insufficiency, especially in late gestation?"], "functions": ["Is there evidence of skeletal development, such as cartilage templates or ossification processes, in the structure?", "Does the image show evidence of trophoblast invasion or development of a maternal-fetal interface?", "Can you see evidence of hormone synthesis, such as production of human chorionic gonadotropin, or influence on maternal endocrine function?"]}}, "b6": {"yes_questions": {"contexual_properties": ["Does the image show evidence of increased concentration of a nutrient following supplementation, either orally or by injection?", "Is there any indication of decreased levels of a micronutrient in the context of malnutrition, disease, or high metabolic demand?", "Can you identify signs that might suggest a deficiency due to poor dietary intake, impaired absorption, or elevated metabolic requirements?", "Is there evidence of tissue accumulation of a substance that could result from excessive supplementation or impaired kidney function?", "Does the image suggest a scenario where nutrient levels might decrease due to increased requirements, such as during pregnancy?", "Is there any indication of decreased nutrient levels in association with kidney disease or renal dysfunction?", "Can you see features that might be associated with poor nutrition or malnutrition leading to reduced nutrient levels?", "Is there evidence of increased levels of a micronutrient following high-dose supplementation?", "Does the image suggest the use of medications like isoniazid, penicillamine, or oral contraceptives that could lower certain nutrient levels?", "Is there any indication of decreased nutrient levels in the context of liver disease or hepatic dysfunction?", "Can you identify signs of instability or degradation of a compound due to exposure to heat, light, or alkaline conditions?", "Does the image suggest the presence of a metabolic disorder, such as homocystinuria, that could alter nutrient metabolism or utilization?", "Is there evidence of decreased nutrient levels in elderly individuals, possibly due to reduced intake or absorption?", "Can you see signs of infection or inflammation that might be associated with increased metabolic turnover and decreased nutrient levels?", "Is there any indication of chronic alcoholism that could result in poor dietary intake and impaired absorption of a micronutrient?", "Does the image suggest a history of bariatric surgery that could lead to reduced absorption of nutrients in the gastrointestinal tract?", "Is there evidence of gastrointestinal disorders, such as celiac disease or Crohn\u2019s disease, that could impair nutrient absorption?", "Can you identify features of chronic inflammatory conditions that might cause decreased nutrient levels due to increased demand or altered metabolism?", "Does the image suggest periods of physical or psychological stress that could increase metabolic requirements and lower nutrient levels?", "Is there any indication of dietary changes, such as increased intake or dietary restriction, that could affect the levels of a micronutrient?"], "properties": ["Does the image contain a molecule featuring a pyridine ring with functional groups characteristic of pyridoxine, pyridoxal, or pyridoxamine?", "Can you identify a compound with a molecular weight close to 169.18 g/mol?", "Is there a substance present that appears as a white or colorless crystalline powder?", "Does the image show a compound that is moderately soluble in water, with solubility around 20\u201325 mg/mL at room temperature?", "Can you find a substance with a melting point in the range of 206\u2013209\u00b0C?", "Is there a compound that decomposes before reaching its boiling point under standard conditions?", "Does the image include a substance whose normal concentration in human blood plasma is between 5 and 50 nmol/L?", "Can you identify a compound that is stable in environments with a pH between 2 and 7, but less stable at higher pH?", "Is there a substance for which the typical daily requirement in adults is about 1.3 to 2.0 mg?", "Does the image show a molecule that could exist in forms such as pyridoxal 5'-phosphate, pyridoxine, or pyridoxamine?", "Can you find a compound with high bioavailability from dietary sources, typically between 75% and 100%?", "Is there a substance with a biological half-life of approximately 15 to 20 days in the human body?", "Does the image contain a solid with a density close to 1.3 g/cm\u00b3?", "Can you identify a compound that is absorbed in the intestine at a rate between 75% and 90%?", "Is there a substance typically stored in the liver in amounts ranging from 40 to 150 mg in healthy adults?"], "relational": ["Does the image show a region within the superior lobe of the lung that is part of the bronchopulmonary segmental system?", "Can you identify an area that is connected to a segmental bronchus and pulmonary arteries?", "Is there a structure present that contains respiratory epithelium and alveolar cells?", "Does the image include a segment adjacent to other bronchopulmonary segments and intersegmental septa?", "Can you see a region that maintains anatomical relationships with the heart and pleura through its position in the lung?", "Is there an area composed of a segmental bronchus, segmental artery, and associated alveoli?", "Does the image show vessels such as a segmental pulmonary artery, segmental pulmonary vein, or lymphatic vessels within a lung segment?", "Can you identify anatomical boundaries defined by intersegmental planes or connective tissue septa?", "Is there a structure that interacts with both the circulatory and lymphatic systems within the lung?"], "contexual_behavior": ["Does the image show evidence of decreased enzyme activity that could result from reduced coenzyme availability in deficiency states?", "Is there a visual indication of increased neurotransmitter synthesis that might occur during periods of physiological or psychological stress?", "Can you identify features suggesting impaired function related to chronic kidney disease, possibly due to altered metabolism of a coenzyme?", "Does the image depict a scenario such as pregnancy or lactation where metabolic requirements for certain nutrients are heightened?", "Is there evidence of inefficient homocysteine metabolism, which could be linked to insufficient coenzyme levels or genetic enzyme disorders?", "Does the image suggest anemia that might be associated with decreased activity in heme synthesis pathways?", "Can you see signs of reduced immune function during infection that may be related to depletion of a coenzyme-dependent process?", "Is there a visual cue indicating altered metabolism in liver disease, possibly affecting hepatic conversion or storage of a specific coenzyme?", "Does the image suggest increased utilization of metabolic pathways, such as during a high-protein diet, that would require greater coenzyme involvement?", "Are there indications of compromised metabolic function that could be due to drug interactions with medications like isoniazid or oral contraceptives?", "Can you observe features consistent with reduced glycogen breakdown during prolonged fasting, potentially due to depleted coenzyme stores?", "Is there evidence of altered amino acid metabolism that might be seen in metabolic disorders affecting transamination or decarboxylation?", "Does the image show signs of decreased coenzyme function that could be associated with aging, such as reduced absorption or dietary insufficiency?", "Are there visual signs of increased neurotransmitter production during inflammation, possibly due to upregulated synthesis pathways?", "Can you identify features of impaired red blood cell formation that might result from malabsorption syndromes affecting intestinal uptake of a key nutrient?"], "functions": ["Does the image show evidence of a process that requires an enzyme cofactor for amino acid metabolism, such as transamination or decarboxylation?", "Is there a structure or process depicted that involves the synthesis of neurotransmitters like serotonin, dopamine, or GABA?", "Can you identify features related to immune function, such as lymphocyte proliferation or antibody production?", "Does the image include any indication of heme synthesis or hemoglobin production, which are essential for red blood cell formation?", "Is there visual evidence of energy metabolism processes like glycogenolysis or gluconeogenesis?", "Can you see any cellular activity that might be associated with nucleic acid synthesis, such as one-carbon metabolism or the folate cycle?", "Is there a process or structure involved in the regulation of homocysteine levels, possibly through the transsulfuration pathway?", "Does the image suggest modulation of steroid hormone receptor binding or hormone synthesis?", "Are there features that could be linked to cognitive function, such as neuronal health or neurotransmitter production?", "Can you identify any signs of erythropoiesis or red blood cell formation?", "Is there evidence of metabolic pathways involving carbohydrates, fats, or proteins that depend on coenzyme activity?"]}, "no_questions": {"contexual_properties": ["Can you identify a structure with increased lymphocyte infiltration, indicating an active cell-mediated immune response?", "Is there a structure with high cellularity, suggesting heightened immune cell recruitment in an early or active stage?", "Is there a region that appears softer, possibly due to early inflammation or the development of necrosis?"], "properties": ["Is there a structure with a moderate to high collagen content, especially in a fibrous capsule?", "Does the image contain a region where necrosis is absent or minimal?", "Can you identify an area composed predominantly of epithelioid cells and lymphocytes, with occasional multinucleated giant cells?"], "relational": ["Does the image show a granuloma with minimal or absent caseous necrosis?", "Does the image show a lesion located in the lung, skin, or lymph node?", "Is there an area surrounded by a rim of lymphocytes or fibroblasts?"], "contexual_behavior": ["Is there a structure whose ability to restrict pathogen growth could be compromised in the setting of malnutrition and impaired immune cell function?", "Does the image display a well-organized cellular barrier that increases containment function in localized infection?", "Is there evidence of impaired antigen presentation, possibly due to genetic immune deficiencies affecting MHC or T-cell function?"], "functions": ["Does the image reveal an organized aggregation of lymphocytes and macrophages forming a structured lesion?", "Can you see signs of macrophage and T cell activation targeting infected cells?", "Can you identify a lesion that physically restricts the spread of Mycobacterium?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Does the image show evidence of fibrosis in a region that might be affected by chronic inflammation?", "Is there a change in density within a space that could be due to fluid, blood, fat, or tumor infiltration?", "Is there visible gas in a region that could result from bowel perforation, infection with gas-forming organisms, or trauma?"], "properties": ["Is there a region where adipose tissue, connective tissue, blood vessels, lymphatics, and nerves are commonly found together?", "Can you see an area that would likely appear pale yellow to whitish due to its fat and connective tissue content?", "Is there a region that could have a thickness between 1 and 3 centimeters?"], "relational": ["Can you distinguish a compartment that is adjacent to both the peritoneal cavity and the pelvic cavity?", "Does the image display connective tissues such as transversalis fascia, renal fascia, or adipose tissue in a posterior abdominal location?", "Does the image show a region located in the posterior part of the abdominal area?"], "contexual_behavior": ["Can you identify tissue that may have lost structural integrity due to infection, such as areas of necrosis or abscess formation?", "Is there visible fat in the image that might serve a protective function, and could this protection be diminished in cases of significant weight loss or cachexia?", "Is there evidence of lymphatic dysfunction, such as might occur in lymphedema due to lymphatic vessel obstruction or damage?"], "functions": ["Can you identify an organ involved in regulating fluid balance by filtering blood and forming urine?", "Is there a visible lymph node or tissue contributing to immune defense or pathogen surveillance?", "Does the image include an organ participating in metabolic processes such as gluconeogenesis or vitamin D activation?"]}}}
[ { "answer": "dr garcia tumors b5", "extracted_concepts": [ "tumors" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "tumors b5" ], "question": "does this image show dr garcia tumors b5?" }, { "answer": "no", "extracted_concepts": [ "b5", "tumors" ], "question": "does child show dr garcia tumors b5?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "granulosa cell tumor" ], "question": "is granulosa cell tumor present?" }, { "answer": "multiple myeloma", "extracted_concepts": [ "multiple myeloma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "multiple myeloma" ], "question": "is multiple myeloma present?" }, { "answer": "no", "extracted_concepts": [ "section", "adrenal capsule" ], "question": "is outside adrenal capsule section present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "multiple myeloma", "extracted_concepts": [ "multiple myeloma" ], "question": "what is present?" } ]	["tumors b5", "granulosa cell tumor", "bone", "multiple myeloma", "tumors", "calvarium", "b5", "section", "adrenal capsule"]	{"tumors b5": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears larger than surrounding tissue, suggesting active cell proliferation or tumor progression?", "Can you identify an area that has decreased in size, possibly indicating a response to therapy or tumor regression?", "Does the image show a mass with an irregular or changing shape, which could be due to uneven growth, invasion, or treatment effects?", "Is there a region that appears denser than adjacent tissue, potentially due to increased cellularity or fibrosis?", "Can you see an area that is less dense, which might be explained by necrosis, cystic change, or edema?", "Does the image reveal a mass with color changes that could result from altered vascularity, hemorrhage, or necrosis?", "Is there evidence of necrotic regions within a mass, possibly due to insufficient blood supply or rapid growth?", "Can you identify calcified areas within a lesion, which may have developed from dystrophic calcification or as a result of therapy?", "Does the image show a structure with increased vascularity, suggesting angiogenesis or aggressive progression?", "Is there a region with reduced vascularity, possibly following necrosis, anti-angiogenic therapy, or regression?", "Can you observe a mass with heterogeneous composition, such as mixed areas of necrosis, fibrosis, or cystic change?", "Is there a lesion containing cystic regions, which could be due to liquefactive necrosis or degeneration?", "Does the image show a structure with increased cellularity, indicating rapid tumor cell proliferation?", "Can you see a region with decreased cellularity, possibly resulting from cytotoxic therapy or extensive necrosis?", "Is there evidence of increased mitotic figures within a mass, suggesting high proliferative activity or aggressiveness?", "Does the image reveal a lesion surrounded by a fibrous capsule, which may indicate a benign or slow-growing process?", "Can you identify a mass that appears to invade surrounding tissues, consistent with malignant transformation or aggressive behavior?", "Is there a change in surface texture of a lesion, such as ulceration or fibrosis, possibly due to rapid growth?", "Does the image show hemorrhagic areas within a mass, which could result from vessel rupture or rapid angiogenesis?", "Is there a structure whose appearance could be correlated with changes in measurable biomarker levels during progression, treatment response, or recurrence?"], "properties": ["Is there a mass in the image that measures between 2 and 5 centimeters in diameter?", "Can you identify a structure that appears to weigh approximately 10 to 30 grams?", "Does the image show a lesion with an irregular or nodular outline?", "Is there a mass displaying a pale tan to grayish-white coloration?", "Can you see a region composed of malignant epithelial cells, stromal cells, and occasional inflammatory cells?", "Is there evidence of a high mitotic index, such as more than 10 mitoses per 10 high-power fields, in any area?", "Does any structure exhibit an elevated nuclear-to-cytoplasmic ratio, greater than 1:1?", "Can you identify a neoplasm that would be classified as high grade based on its features?", "Is there a mass with an estimated density between 1.05 and 1.10 grams per cubic centimeter?", "Does any tissue appear to have a water content of approximately 70% by weight?", "Is there evidence of overexpression of markers such as Ki-67, p53, or cytokeratins in any region?", "Can you see a lesion with moderate to high vascularity, indicated by numerous small blood vessels?", "Is there an area where 10% to 40% of the mass appears necrotic?", "Does any structure have a low lipid content, less than 5% of its tissue mass?", "Is there evidence of aneuploid DNA content or abnormal chromosomal numbers in any cell population?", "Can you identify a rapidly growing mass, potentially with a doubling time of less than 30 days?", "Does any region appear to have an acidic microenvironment, with a pH between 6.5 and 7.0?", "Is there a tissue area that feels or appears firm and heterogeneous in texture?", "Can you see a region with high cellularity, where tumor cells are densely packed?", "Is there evidence of frequent structural rearrangements or numerical chromosomal aberrations in any cell population?"], "relational": ["Does the image show an abnormal mass that could originate from epithelial, connective, or muscle tissue?", "Is there a lesion present in organs such as the lung, liver, or colon?", "Can you identify a structure located within the thoracic, abdominal, or pelvic regions?", "Does the image contain a mass composed of neoplastic, stromal, or immune cells?", "Is there a visible structure surrounded by a fibrous capsule or adjacent parenchyma?", "Can you see a mass associated with regional lymph nodes or lymphatic vessels?", "Does the image show a lesion supplied by small blood vessels such as arterioles, capillaries, or venules?", "Is there evidence of an abnormality impacting the circulatory, lymphatic, or immune systems?", "Can you identify a structure separated from surrounding tissues by a basement membrane or connective tissue septa?", "Does the image contain a mass within the pleural, peritoneal, or pelvic cavity?"], "contexual_behavior": ["Is there evidence of increased cell proliferation in regions where oxygen levels appear low, suggesting adaptation to hypoxic conditions?", "Can you identify areas where immune cells seem unable to infiltrate or attack, possibly due to enhanced immune evasion mechanisms?", "Are there regions that appear resistant to cell death following chemotherapy, indicating upregulation of anti-apoptotic pathways or drug efflux activity?", "Do you observe signs of altered metabolic activity, such as increased glycolysis or use of alternative energy sources, in areas with limited nutrients?", "Is there visible evidence of new blood vessel formation in response to low oxygen, consistent with pro-angiogenic factor secretion?", "After radiation exposure, do any regions show decreased proliferation or signs of cell cycle arrest due to DNA damage response?", "Can you detect invasive growth into surrounding tissues, possibly facilitated by increased matrix-degrading enzyme activity or reduced cell adhesion?", "Are there indications of immune evasion, such as the presence of immunosuppressive ligands or recruitment of regulatory immune cells?", "Do you see increased secretion of growth factors in areas with elevated inflammation or cytokine signaling?", "Is there evidence of reduced sensitivity to targeted therapies, such as persistence of growth despite treatment, suggesting resistance mutations or alternative pathway activation?", "Are there signs of altered signaling pathways in response to hormonal changes, such as modulation of hormone receptor expression?", "Can you identify features associated with increased metastatic potential, such as activation of epithelial-mesenchymal transition or enhanced cell motility under chronic stress?", "Do any regions show decreased metabolic flexibility when metabolic inhibitors are present, indicating enzyme blockade or failure of compensatory pathways?", "Is there evidence of genomic instability or failure to repair DNA damage after genotoxic stress, suggesting DNA repair deficiency?", "Are there areas with increased glycolytic activity during rapid growth, consistent with the Warburg effect?", "Do you observe reduced antigen presentation in the microenvironment, possibly due to downregulation of MHC molecules?", "Is there evidence of increased production of immunosuppressive molecules in response to inflammatory cytokines or immune cell infiltration?", "Are there regions where proliferation decreases in response to nutrient scarcity, indicating activation of energy-sensing pathways and cell cycle arrest?", "Do you see behavioral changes during anti-angiogenic therapy, such as activation of alternative vascularization mechanisms or increased invasiveness?", "Are there signs of increased resistance to oxidative stress, such as upregulation of antioxidant defenses or neutralization of reactive oxygen species?"], "functions": ["Does the image show a structure exhibiting signs of uncontrolled cell proliferation or abnormal tissue architecture?", "Is there evidence of invasion into surrounding tissues or features suggesting potential for metastasis?", "Can you identify an area where abnormal cell division or tissue remodeling appears to be occurring?", "Does the image reveal disruption of normal cellular organization, possibly indicating cell cycle dysregulation or impaired differentiation?", "Is there a region where apoptosis seems to be inhibited, such as clusters of densely packed cells?", "Can you observe features that might indicate immune evasion, such as reduced immune cell infiltration or altered tissue immune response?", "Does the image contain evidence of new blood vessel formation, possibly due to pro-angiogenic activity?", "Is there a structure that could be associated with increased glycolysis or altered nutrient uptake, as suggested by rapid growth?", "Can you see signs of extracellular matrix degradation or cell migration that might facilitate spread to other tissues?", "Does the image show areas where inflammation, tissue destruction, or altered function of healthy tissue is apparent?", "Is there visual evidence of autocrine signaling or dysregulated growth factor pathways, such as abnormal growth patterns?", "Can you identify regions where the extracellular matrix appears remodeled, possibly due to matrix metalloproteinase activity?", "Does the image suggest the presence of pro-inflammatory cytokine release or recruitment of immune cells in the microenvironment?", "Is there evidence of activation of oncogenic pathways or inhibition of tumor suppressor signals, as indicated by abnormal cellular arrangements or growth?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a tissue that is part of both the skeletal and hematopoietic systems?", "Does the image reveal a tissue residing in the medullary cavity of a bone?", "Does the image show a tissue responsible for producing lymphocytes or other immune cells?"], "contexual_behavior": [], "functions": ["Is there evidence of a microenvironment supporting stem cell proliferation and differentiation?", "Can you see a region where blood cell development is regulated by growth factors or cytokine signaling?", "Can you identify an area involved in immune cell production?"]}}, "granulosa cell tumor": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion affecting the reproductive system?", "Can you identify a mass that appears to originate from ovarian stromal tissue?", "Is there an abnormal structure involving the ovary or, in more advanced cases, the uterus or peritoneum?", "Does the image contain a tumor composed of granulosa cells, or possibly theca cells and fibroblasts?", "Can you see a mass adjacent to the ovarian cortex, fallopian tube, or pelvic peritoneum?", "Is there a lesion located within the pelvic cavity?", "Does the image show a growth arising from or closely related to the ovary?", "Can you identify a structure that invades or compresses the ovarian capsule, fallopian tube, uterus, or other pelvic organs?", "Is there evidence of involvement of pelvic lymph nodes or para-aortic lymph nodes near a mass?", "Does the image show a lesion supplied by the ovarian artery or branches of the uterine artery?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a neoplastic growth that disrupts normal ovarian tissue structure?", "Is there a mass present that could be responsible for altering endocrine function within the ovary?", "Can you identify a lesion that might be associated with overproduction of hormones such as estrogen or inhibin?", "Does the image contain a structure that could lead to excess estrogen secretion?", "Is there a mass that might be linked to irregularities in the menstrual cycle due to hormonal imbalance?", "Can you see evidence of tissue replacement or loss of normal ovarian architecture that could impair ovarian function?", "Is there a lesion that could contribute to endometrial proliferation or signs of endometrial hyperplasia?", "Does the image suggest abnormal bleeding or thickening of the endometrial lining that could be secondary to hormone-secreting pathology?", "Is there a structure that might be responsible for inhibin secretion and subsequent suppression of follicle-stimulating hormone (FSH) levels?", "Can you identify a mass that could reduce fertility by disrupting ovulation or damaging ovarian reserve?", "Does the image show evidence of tissue invasion or compression affecting surrounding ovarian tissue?", "Is there a lesion that could induce premature or exaggerated development of secondary sexual characteristics due to excess estrogen?", "Can you see features that suggest disruption of the hypothalamic-pituitary-gonadal axis feedback mechanisms, such as gonadotropin suppression?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?"], "relational": ["Can you identify structures formed by bones such as the maxilla or mandible?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?"], "contexual_behavior": [], "functions": ["Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a vessel that passes through both the thoracic and abdominal regions?", "Does the image show a structure that is part of the cardiovascular system?", "Does the image show a structure originating at the aortic root and receiving blood from the left ventricle via a valve?"], "contexual_behavior": [], "functions": ["Can you see a structure that receives blood during ventricular systole and releases it steadily during diastole?", "Does the image show a structure responsible for transporting oxygen-rich blood from the heart to the rest of the body?", "Can you identify a vessel that branches into major arteries supplying all regions of the body?"]}}, "multiple myeloma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a disease affecting the hematopoietic system?", "Can you identify abnormalities within bone marrow tissue?", "Is there a visible proliferation of plasma cells?", "Are there lesions present in anatomical sites such as the vertebrae, ribs, pelvis, or skull?", "Does the image reveal disruption of normal bone marrow structure or function?", "Are there signs of involvement in the spine, pelvis, ribs, or long bones?", "Can you observe changes that might indicate altered levels of immunoglobulins, red blood cells, or calcium?", "Is there any indication of interaction between abnormal cells and lymphatic structures like lymph nodes or spleen?", "Do you see evidence of damage to organs such as the kidneys, bones, or components of the immune system?", "Are there features suggesting impaired immune function, such as abnormal antibody production or immune suppression?"], "contexual_behavior": [], "functions": ["Does the image show evidence of widespread dysfunction affecting multiple organs, such as the skeletal, renal, hematopoietic, or immune systems?", "Can you identify any areas of bone destruction, such as lytic lesions or pathological fractures?", "Is there visual evidence of anemia, such as reduced red blood cell presence or signs of decreased erythropoiesis in the bone marrow?", "Does the image suggest suppression of immune function, such as reduced numbers of healthy immune cells or signs of immunodeficiency?", "Can you see abnormal plasma cells that appear to be proliferating uncontrollably within the bone marrow?", "Is there evidence of monoclonal protein accumulation, such as abnormal deposits or changes in blood composition?", "Does the image show signs of bone marrow infiltration, with malignant cells crowding out normal hematopoietic elements?", "Can you identify features consistent with increased osteoclast activity or inhibited osteoblast function, such as areas of osteolysis?", "Is there any indication of kidney dysfunction, such as changes in renal tissue that could be associated with light chain deposition or hypercalcemia?", "Does the image reveal signs of hypercalcemia, possibly related to increased bone resorption?", "Can you see evidence of cytokine-mediated suppression or other factors inhibiting normal bone marrow activity?", "Is there any indication of increased risk of infection, such as reduced levels of functional immunoglobulins or compromised immune cell populations?", "Does the image suggest the presence of paraproteinemia, such as abnormal protein deposits in blood or tissues?", "Can you identify features that indicate complications involving the skeletal, renal, hematopoietic, or immune systems?"]}, "no_questions": {"contexual_properties": ["Does the image display a mass whose size appears increased, possibly due to cell proliferation or accumulation of abnormal material?", "Can you see an area with an increased or decreased number of cells, indicating proliferation, infiltration, or cell depletion?", "Can you observe any change in color of a visible manifestation, such as increased redness, bluish discoloration, or darkening?"], "properties": ["Is there any indication of the proportion of affected individuals who may not survive, suggesting a mortality rate?", "Can you estimate the prevalence of the condition in the depicted population based on the image?", "Does the visual presentation suggest a mild, moderate, or severe clinical severity?"], "relational": ["Does the image suggest disruption of nerve pathways, blood circulation, or lymphatic drainage?", "Is there evidence of anatomical barriers like the blood-brain barrier, mucosal barrier, or skin influencing the spread of a condition?", "Are there visible changes in the thoracic, abdominal, or cranial regions?"], "contexual_behavior": ["Does the image show a process that appears less active, possibly corresponding to a remission phase with reduced symptoms?", "Can you see indications that the activity of a pathological process is increased during pregnancy, possibly due to hormonal or immunological changes?", "Is there evidence of a condition that appears more severe in the context of diminished host immune defenses?"], "functions": ["Does the image suggest instability or imbalance in regulatory mechanisms responsible for maintaining homeostasis?", "Does the image show evidence of abnormal changes that could impair normal physiological functions?", "Can you identify any signs of disrupted biochemical pathways or organ system activities?"]}}, "tumors": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears to be increasing in size, suggesting active cell division or growth?", "Can you identify an area that seems to have decreased in size, possibly indicating a response to therapy or immune activity?", "Does the image show a region with altered coloration that could be due to changes in blood supply, necrosis, or hemorrhage?", "Is there evidence of increased vascularization in any structure, which might suggest angiogenesis stimulated by growth factors?", "Can you see a region that appears necrotic, possibly due to insufficient blood supply or rapid expansion?", "Is there a visible area with calcifications, which could result from chronic necrosis or degeneration?", "Does the image show a structure with cystic features, such as central degeneration or fluid accumulation?", "Can you identify a region with variable density, possibly reflecting differences in cellularity, fibrosis, necrosis, or calcification?", "Is there an area that appears firmer or denser, which might be due to increased fibrosis or a desmoplastic reaction?", "Do you see a region that looks softened, perhaps as a result of necrosis, liquefaction, or cyst formation?", "Is there evidence of increased cellularity in any structure, which could indicate rapid proliferation or a high-grade lesion?", "Does any area display irregular borders, suggesting invasion into surrounding tissues or loss of encapsulation?", "Can you identify a region with mixed composition, such as areas of necrosis, hemorrhage, fibrosis, or cystic change?", "Is there a structure that appears hypermetabolic, possibly due to rapid growth or malignant transformation?", "Do you see a surface defect or ulceration, which might result from outgrowing the blood supply or invasion of overlying tissue?", "Is there evidence of hemorrhage within a structure, possibly due to fragile new blood vessels or vascular invasion?", "Can you observe any changes that might correspond to fluctuations in marker levels, such as progression, recurrence, or response to treatment?", "Does any region appear more heterogeneous, potentially due to genetic mutations, necrosis, or hemorrhage?", "Is there a structure that seems to have lost its capsule and is infiltrating adjacent tissues, indicating invasive behavior?", "Do you see signs of edema, such as swelling or fluid accumulation, which could result from disrupted vasculature or inflammation?"], "properties": ["Is there a mass in the image whose size appears variable, ranging from a few millimeters to several centimeters?", "Can you identify a structure that could weigh anywhere from less than a gram to several kilograms, depending on its characteristics?", "Does the image show a mass with an irregular, nodular, or spherical shape?", "Is there an area that appears pale, gray, white, red, or yellow in color, possibly reflecting differences in vascularity or necrosis?", "Can you see a structure that looks firm, hard, soft, or gelatinous in consistency?", "Is there a mass that might be composed of neoplastic, stromal, inflammatory, or endothelial cells?", "Does the image suggest a region where cell division is elevated compared to surrounding tissue?", "Is there evidence of a structure that could be growing more rapidly than the adjacent normal tissue?", "Can you identify an area with increased or heterogeneous vascularity, possibly due to angiogenesis?", "Does the image show a region that might contain significant necrotic content, especially in rapidly growing or poorly vascularized areas?", "Is there a mass with density higher than that of the surrounding tissue, or with variable density depending on its composition?", "Can you see a structure that might have a high water content, similar to or slightly less than normal tissue?", "Is there an area that could be associated with altered protein expression, such as overexpression or loss of markers like Ki-67, p53, or HER2?", "Does the image suggest the presence of cells with abnormal DNA content, such as aneuploidy or increased DNA replication?", "Is there a region that could have a lower pH, possibly between 6.5 and 7.0, due to increased glycolysis?", "Can you identify an area that might be hypoxic, with reduced oxygen concentration compared to normal tissue?", "Does the image show a region where glucose uptake or concentration might be elevated?", "Is there a mass that could have increased lipid content, particularly if it resembles tissue types like liposarcoma?", "Can you see evidence of high cellular atypia, such as pleomorphism or abnormal cell morphology?", "Is there a region where the nuclear-to-cytoplasmic ratio appears increased, indicating larger nuclei relative to cytoplasm?"], "relational": ["Does the image show an abnormal mass originating from epithelial, connective, muscle, or nervous tissue?", "Can you identify a lesion present within the lung, liver, breast, colon, or brain?", "Is there a structure that could impact the nervous, respiratory, digestive, or endocrine system?", "Does the image display a mass adjacent to blood vessels, nerves, lymph nodes, or other organs?", "Can you see a region containing neoplastic, stromal, immune, or endothelial cells?", "Is there evidence of arterioles, capillaries, venules, or newly formed blood vessels supplying a mass?", "Does the image show lymphatic vessels, regional lymph nodes, or lymphatic capillaries interacting with a suspicious structure?", "Is there an abnormality located in the head and neck, thorax, abdomen, pelvis, or extremities?", "Can you observe a mass interacting with surrounding connective tissue, possibly through invasion or tissue remodeling?", "Is there a structure that appears to cross anatomical barriers such as the basement membrane, blood-brain barrier, serosal membranes, or fascia?"], "contexual_behavior": ["Is there a structure in the image that appears to have increased blood vessel formation, possibly indicating enhanced angiogenesis?", "Can you identify an area that might be resisting immune cell infiltration or showing signs of immune evasion?", "Does the image show a region where cells could be adapting to low oxygen by increasing glycolytic activity?", "Is there evidence of a mass that might be less responsive to chemotherapy, suggesting drug resistance?", "Can you see a structure that appears to be invading surrounding tissues, possibly in response to inflammation?", "Is there a mass that seems to be disrupting the normal architecture of nearby tissue, potentially suppressing local function?", "Does the image show a region where growth rate appears reduced, possibly due to nutrient deprivation or metabolic adaptation?", "Can you identify an area where cells might be avoiding programmed cell death, suggesting evasion of apoptosis?", "Is there a mass that appears to have decreased proliferation, possibly following radiation therapy?", "Does the image show a region that could be secreting immunosuppressive factors, as indicated by reduced immune cell presence nearby?", "Is there evidence of altered cell adhesion or motility in response to hormonal influence, possibly affecting metastatic potential?", "Can you see a mass that is compressing or infiltrating adjacent organs, potentially causing dysfunction due to mass effect?", "Is there a region where increased glycolysis might be occurring in response to low oxygen levels?", "Does the image show an area where antigen presentation to immune cells may be reduced, possibly due to downregulation of MHC molecules?", "Can you identify a structure that might be adapting its behavior in response to targeted therapy, such as by activating alternative signaling pathways?", "Is there evidence of increased production of growth factors to support proliferation and new blood vessel formation?", "Does the image show a mass with reduced growth, possibly following anti-angiogenic treatment and decreased vascular supply?", "Can you see a region that appears to be recruiting stromal cells, as indicated by increased presence of supporting cell types?", "Is there evidence of impaired cell cycle regulation, possibly due to genetic mutations affecting regulatory genes?", "Does the image show a structure that might be resisting oxidative stress, as suggested by features indicating upregulated antioxidant defenses?"], "functions": ["Does the image show a region where cell growth appears uncontrolled or excessive compared to surrounding tissue?", "Can you identify an area that seems to invade or disrupt the normal architecture of adjacent structures?", "Is there evidence of a mass compressing nearby anatomical features or altering organ performance?", "Does the image reveal a structure that could be dysregulating the cell cycle or promoting genetic instability?", "Can you see a region where abnormal cell proliferation might be driven by sustained mitogenic signaling?", "Is there a visible area that could be evading immune detection, such as by lacking typical antigen presentation markers?", "Does the image show evidence of new blood vessel formation, possibly due to secretion of vascular endothelial growth factors?", "Can you identify a structure that appears to degrade the extracellular matrix or invade surrounding tissues?", "Is there a region that might be entering blood or lymphatic vessels, suggesting potential for metastasis?", "Does the image display features consistent with increased glycolysis or altered metabolic activity in a localized area?", "Can you see a structure that seems resistant to programmed cell death, such as by persisting despite cellular stress or damage?", "Is there evidence of recruitment or activation of stromal cells in the vicinity of an abnormal mass?", "Does the image show signs of chronic inflammation, such as accumulation of inflammatory cells near a suspicious area?", "Can you identify a region that might be producing ectopic hormones or disrupting normal endocrine feedback?", "Is there a visible interaction between an abnormal structure and immune or stromal cells, such as recruitment of fibroblasts or macrophages?", "Does the image reveal obstruction of ducts or vessels, tissue necrosis, or impairment of physiological processes in association with a mass?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of widely spaced eyes or increased distance between the eyes?", "Are the ears positioned lower than usual or do they appear abnormally shaped?", "Does the skin color appear normal or is there any sign of pallor?"], "relational": ["Are there visible alterations in the skin, subcutaneous tissue, or cartilage of the face?", "Is there evidence of abnormalities in the midface, periorbital region, or mandibular area?", "Is there any indication of developmental issues such as oligohydramnios reflected in the facial appearance?"], "contexual_behavior": ["Does the image show facial features that could be associated with prolonged or severe deficiency of amniotic fluid during gestation?", "Are there facial features that appear less distinct, potentially indicating that amniotic fluid levels normalized before mid-gestation?", "Does the image lack the typical facial changes expected when urinary tract obstruction is mild and amniotic fluid remains sufficient?"], "functions": ["Do you observe eyelid abnormalities or reduced facial tone that might hinder effective blinking or eye protection?", "Does the facial appearance suggest diminished ability to express emotions or reduced facial expressivity?", "Is there visual evidence of poor oral competence, such as drooling or difficulty controlling saliva?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image show a structure that maintains its integrity but may appear fragile depending on the tissue type?", "Is there a feature that has a rectangular or oval shape, reflecting the geometry of original tissue?", "Is there a region composed of cellular elements, extracellular matrix, and interstitial fluid?"], "relational": ["Does the image appear to be oriented along a sagittal, coronal, or transverse anatomical plane?", "Are there distinct layers such as mucosa, submucosa, muscularis, or serosa visible within an organ in the image?", "Are cell types such as epithelial cells, muscle cells, fibroblasts, or neurons visible in the sectioned area?"], "contexual_behavior": ["Is there evidence of compromised barrier function that might be related to hyperglycemia, as seen in diabetes?", "Is there a region that appears more susceptible to infection, possibly due to impaired immunity in an immunocompromised state?", "Can you detect abnormal tissue remodeling that could be influenced by tumor-associated factors in a cancerous environment?"], "functions": ["Is there a perspective that allows direct observation of abnormal features such as lesions or tumors?", "Can you see an arrangement of tissues that reveals their spatial organization or layering within an organ?", "Is there a view that helps correlate anatomical features with physiological functions by exposing internal architecture?"]}}, "b5": {"yes_questions": {"contexual_properties": ["Does the image show evidence of increased concentration of a nutrient following supplementation or high dietary intake?", "Is there a sign of decreased levels of a micronutrient in the context of malnutrition, chronic illness, or poor absorption?", "Can you identify tissue changes that might indicate deficiency due to insufficient intake or impaired absorption of a vitamin?", "Is there evidence of accumulation of a compound in the liver or kidneys that could result from excessive supplementation or metabolic dysfunction?", "Does the image suggest altered nutrient levels in association with gastrointestinal disorders affecting absorption, metabolism, or excretion?", "Can you observe features that might reflect fluctuations in nutritional status, such as changes after consumption of nutrient-rich foods or with poor diet?", "Is there any indication of absorption abnormalities possibly linked to inflammatory bowel disease or recent gastrointestinal surgery?", "Does the image provide clues to instability of a substance in the bloodstream, perhaps due to rapid metabolism or exposure to high temperatures?", "Is there evidence of abnormal urinary excretion that could be associated with renal dysfunction or excessive intake of a nutrient?", "Can you see signs of metabolic disorders that might affect the synthesis or breakdown of a vitamin?", "Does the image suggest rapid degradation of a compound during periods of increased metabolic demand or enzymatic defects?", "Is there any indication of increased excretion of a nutrient in the context of high intake, kidney disorders, or diuretic use?", "Can you identify features that might reflect decreased bioavailability of a compound due to gastrointestinal disease, drug interactions, or poor dietary sources?", "Does the image show changes that could be attributed to increased metabolic requirements during physical or psychological stress?", "Is there evidence of altered nutrient levels that might be related to pregnancy and increased physiological demand?", "Can you observe features suggesting decreased concentration of a nutrient in elderly individuals, possibly due to reduced intake or absorption?", "Does the image indicate inadequate dietary supply leading to reduced availability of a micronutrient in malnutrition?", "Is there any sign of abnormal plasma levels of a compound that could be associated with metabolic disorders, malnutrition, or renal disease?", "Can you see evidence of decreased levels of a nutrient during infection, possibly due to increased metabolic utilization and immune response?", "Does the image suggest altered tissue distribution of a compound in the context of metabolic disease or organ dysfunction affecting storage and transport?"], "properties": ["Is there a substance in the image that has the chemical formula C9H17NO5 and contains a linear chain with a pantoic acid moiety linked to \u03b2-alanine?", "Can you identify a compound that appears as a white, crystalline powder?", "Does the image show a material that is highly soluble in water?", "Is there an object whose aqueous solution would have a pH between 6.5 and 7.5?", "Can you see a substance that is stable under physiological conditions but may degrade under extreme heat or acidic/alkaline environments?", "Is there a compound present that decomposes at around 187\u00b0C and does not have a defined boiling point?", "Does the image include something with a molecular weight close to 219.24 g/mol?", "Can you identify a material with a density of approximately 1.2 g/cm\u00b3?", "Is there a substance that is commonly found in supplements as either calcium pantothenate or as an acid form?", "Does the image contain something that, in human tissues, would typically be present at concentrations between 2 and 7 mg/kg?", "Can you see a compound that, when administered clinically, is typically dosed between 5 mg and 100 mg per day?", "Is there an object whose bioavailability in healthy individuals would exceed 50%?", "Does the image show a substance with a biological half-life of about 1 to 2 hours in the human body?", "Can you identify something that is required in the adult diet at a level of approximately 5 mg per day?"], "relational": ["Does the image show a segment located in the middle lobe of the right lung, specifically in the medial region?", "Can you identify a structure that is part of the respiratory system and belongs to the right lung?", "Is there a region composed of bronchopulmonary tissue, including segmental bronchi and alveoli?", "Does the image contain tissue featuring respiratory epithelium, smooth muscle, and pulmonary connective tissue?", "Can you see a segment that is directly connected to a segmental bronchus and adjacent lung segments?", "Is there evidence of segmental pulmonary arteries, veins, or bronchi associated with a specific region of the right lung?", "Does the image include substructures such as terminal bronchioles, alveolar sacs, or capillary networks within a segment of the right lung?", "Can you identify a region that is bordered by other right lung segments or intersegmental septa?", "Is there a structure in proximity to the pleura or mediastinum within the right lung?"], "contexual_behavior": ["Does the image show evidence of reduced coenzyme activity in metabolic pathways that could result from deficiency or impaired absorption?", "Is there a sign that fatty acid synthesis is not being effectively supported, possibly due to insufficient nutrient levels or high metabolic demand?", "Can you identify features suggesting increased energy metabolism, such as during physical stress or heightened energy requirements?", "Does the image indicate a decline in enzyme function that might be due to inadequate coenzyme availability?", "Is there visual evidence of decreased activity in metabolic processes that could be linked to malnutrition or reduced dietary intake?", "Can you see signs of impaired neurotransmitter synthesis, potentially associated with chronic illness or altered metabolism?", "Is there evidence of enhanced wound healing or cellular repair processes following injury?", "Does the image suggest impaired nutrient function in the context of gastrointestinal disorders affecting absorption or metabolism?", "Are there indications of increased utilization of metabolic resources during periods of rapid growth?", "Can you observe features consistent with impaired adrenal function under prolonged stress or depleted reserves?", "Is there evidence of a shift in metabolic activity, possibly in response to a high-fat diet and altered lipid metabolism?", "Does the image suggest slowed metabolic processes or reduced absorption efficiency that might be associated with aging?", "Are there signs of increased detoxification activity, such as during toxin exposure and enhanced biotransformation?", "Can you identify features that might indicate decreased metabolic function due to alcohol use disorder and impaired absorption?", "Is there evidence of increased hemoglobin synthesis, such as during anemia and enhanced heme biosynthesis?"], "functions": ["Does the image show evidence of a process or structure involved in coenzyme A synthesis?", "Can you identify features related to metabolic activity or cellular function that depend on coenzyme A?", "Is there visual evidence of energy production, such as activity in the Krebs cycle?", "Does the image contain indications of fatty acid synthesis or oxidation processes?", "Can you see structures or processes involved in the metabolism of carbohydrates, proteins, or fats?", "Is there evidence of acyl group transfer reactions occurring in the depicted tissue?", "Does the image show any features associated with hormone synthesis, particularly steroidogenesis in the adrenal glands?", "Can you identify signs of erythropoiesis or heme synthesis in the tissue?", "Is there visual evidence of neurotransmitter production, such as acetylcholine synthesis or nervous system activity?", "Does the image display features related to wound healing, tissue repair, or collagen synthesis?", "Can you see any structures or processes that indicate myelin maintenance or nervous system support?"]}, "no_questions": {"contexual_properties": ["Does the image contain features consistent with bleeding related to placental separation?", "Can you identify signs of blood accumulation near the site where the placenta attaches?", "Is there visual evidence of disrupted placental attachment accompanied by hemorrhage?"], "properties": ["Does the image reveal a collection of fluid containing erythrocytes, plasma, platelets, and coagulation factors?", "Can you see indications that clotting time may be prolonged, possibly exceeding 10 minutes?", "Can you identify an area where the color suggests partially clotted maternal blood, appearing dark red?"], "relational": ["Can you identify blood accumulation near the maternal-fetal interface?", "Does the image show anatomical barriers, such as the chorionic plate or amniotic membrane, separating a blood collection from the fetus?", "Is there a region where the decidua basalis or myometrium appears altered or disrupted?"], "contexual_behavior": ["Is there a visible area suggesting disrupted attachment between the placenta and the uterine wall accompanied by hemorrhage?", "Can you identify signs of bleeding in association with placental tissue?", "Does the image display features consistent with blood loss adjacent to the placenta?"], "functions": ["Can you identify reduced fetal blood flow that might result in fetal anemia or compromised fetal circulation?", "Can you identify disruption of placental integrity that might reduce oxygen and nutrient transfer to the fetus?", "Is there visual indication of decreased maternal blood volume, such as signs that might suggest hypotension or compensatory tachycardia?"]}}, "section": {"yes_questions": {"contexual_properties": ["Does the image show a tissue sample that appears thicker, possibly due to microtome settings or incomplete embedding?", "Is there a sample that looks thinner, which could result from lower microtome thickness or overprocessing?", "Can you identify a tissue area where the color varies, suggesting different stains or changes in tissue composition?", "Does the sample display regions with increased cellularity, as might be seen in hyperplasia, neoplasia, or inflammation?", "Is there an area with decreased cellularity, which could indicate atrophy, necrosis, or degeneration?", "Can you observe any abnormal staining patterns that might result from altered staining protocols or pathological changes?", "Is there evidence of fragmentation in the tissue, possibly due to brittleness, poor fixation, or excessive thinness?", "Does the sample show increased fibrous tissue, as might occur in chronic inflammation or tissue repair?", "Can you see signs of fluid accumulation, such as edema, within the tissue?", "Is there visible deposition of substances like amyloid, hemosiderin, or lipids, suggesting diseases such as amyloidosis or lipidosis?", "Does the sample contain areas of necrosis, possibly due to cell death from injury, ischemia, or toxins?", "Is there a region that appears more transparent, which could be due to thinness, poor staining, or increased extracellular matrix?", "Can you identify a part of the sample that looks opaque, potentially from increased thickness, heavy staining, or dense fibrotic material?", "Does the tissue architecture appear altered, as might be seen in neoplasia, inflammation, or remodeling?", "Is there evidence of increased immune cell infiltration, suggesting inflammation from infection or autoimmune disease?", "Can you observe any loss of structural integrity, which could result from poor fixation, overprocessing, or necrosis?", "Are there areas showing calcification, possibly indicating dystrophic or metastatic calcification?", "Does the sample appear more eosinophilic, which might reflect increased protein content or cell injury?", "Is there a region that appears more basophilic, suggesting increased nucleic acid content or ribosomal activity?", "Can you see abnormal cell morphology, as might occur in dysplasia, malignancy, or viral infection?"], "properties": ["Is there an object in the image that measures between 1 and 5 centimeters in length?", "Can you identify a structure whose width appears to be within the range of 0.5 to 2 centimeters?", "Does the image show a thin object that could be 3 to 10 micrometers thick, as used in histological analysis?", "Is there a rectangular or oval-shaped area present, reflecting a typical cutting method?", "Can you see a region whose area might fall between 0.5 and 10 square centimeters?", "Is there an object whose estimated volume could be between 1 and 100 cubic millimeters, based on its area and thickness?", "Does the image contain a structure that appears pink, purple, or blue, possibly due to staining under light microscopy?", "Can you identify an object that might have a density close to 1.0 to 1.1 grams per cubic centimeter, as expected for biological tissue?", "Is there a region that could be composed of cellular and extracellular components such as proteins, lipids, carbohydrates, and water?", "Does the surface of any structure appear smooth or display microstructural features typical of prepared tissue samples?", "Can you see an object that might have a refractive index in the range of 1.35 to 1.55, as seen in tissue sections?", "Is there evidence of a structure with high water content, possibly comprising 60% to 80% of its mass?", "Can you identify a region that could contain 10% to 20% protein by mass, as is typical for tissue samples?", "Does the image show an area that might have a lipid content between 2% and 30%, depending on tissue type?", "Is there a structure that could contain 1% to 5% carbohydrate by mass?", "Can you observe differences in staining intensity, ranging from weak to strong, across any regions in the image?", "Is there an object that appears to be maintained at room temperature, approximately 20 to 25 degrees Celsius, during analysis?", "Can you identify a region that might have a pH between 6.8 and 7.4, as expected after typical tissue processing?"], "relational": ["Does the image display a specific slice or subdivision of an anatomical structure?", "Can you identify a portion that serves as a component of a larger organ or tissue?", "Is there a defined area where smaller parts such as cells, fibers, or microstructures are visible?", "Does the image show a region that maintains spatial or functional relationships with the entire structure?", "Can you see a portion containing different tissue types, such as epithelial, connective, muscle, or nervous tissue?", "Is there a visible boundary or landmark that could represent a plane of dissection or a natural demarcation?", "Are there adjacent regions or features that could be neighboring subdivisions or connective tissue within the same organ?", "Does the image include a subdivision that might be used in anatomical nomenclature, histology, or surgical classification?", "Can you identify an area that shares borders and appears functionally continuous with neighboring regions?", "Is there evidence that the displayed portion was created using a specific anatomical plane, such as sagittal, coronal, or transverse?"], "contexual_behavior": ["Is there evidence of localized injury in any tissue area, such as disrupted cellular integrity or altered architecture?", "Can you identify a region where metabolic activity might be impaired due to reduced blood supply or signs of hypoxia?", "Does the image show an area with increased cell proliferation or tissue repair, suggesting regenerative activity after damage?", "Is there a muscle region that appears to have reduced contractile function, possibly indicating fatigue or energy depletion?", "Can you see a brain area that might be experiencing abnormal signaling, as could occur during a seizure?", "Is there a section of the intestine that shows signs of inflammation, such as compromised mucosal integrity or reduced absorption?", "Does the lung tissue display features like filled alveolar spaces, which could indicate impaired gas exchange due to infection?", "Is there a heart region with evidence of cell death or scar tissue, suggesting reduced pumping efficiency after infarction?", "Can you identify a kidney area that may have decreased filtration, possibly due to acute injury to glomerular or tubular cells?", "Is there a liver region that appears to be increasing enzyme production, potentially in response to toxins?", "Does any skin area show loss of barrier function, such as disruption of the epidermal layer after trauma?", "Is there a bone region with signs of increased remodeling activity, as might be seen during fracture healing?", "Can you see a glandular tissue area where secretion appears altered, possibly due to hormonal regulation?", "Is there a spinal cord region that might have lost signal transmission, such as after compression or disruption of axonal pathways?", "Does the pancreas show any area with decreased insulin secretion, which could be associated with beta cell dysfunction in diabetes?"], "functions": ["Does the image show a thin slice or subdivision of tissue prepared for analysis?", "Can you identify a sample that allows detailed observation of cellular and structural organization within the tissue?", "Is there a visible area that reveals spatial relationships among cells and extracellular components?", "Does the image contain a sample suitable for microscopic examination of tissue morphology?", "Can you see a region that could be used for histopathological evaluation or disease identification?", "Is there evidence of cellular abnormalities or pathological changes within the tissue sample?", "Does the image allow for the assessment of cell interactions, proliferation, or differentiation within a defined tissue context?"]}, "no_questions": {"contexual_properties": ["Can you identify multiple structures with a villous shape that seem abnormally distended?", "Does the image show finger-like projections that appear enlarged or swollen?", "Is there evidence of numerous elongated surface features that are thicker than usual?"], "properties": ["Does the tissue surface area appear expanded due to an increased number and swelling of villi?", "Are there villous structures with an increased width, commonly between 0.2 and 0.5 mm?", "Are there signs of slightly reduced protein content, such as protein loss into the interstitial space?"], "relational": ["Is there evidence of projections located in regions such as the duodenum, jejunum, or ileum?", "Are there visible capillary loops, arterioles, or venules supplying any of the projections?", "Can you see lymphatic structures such as lacteals or lymphatic capillaries associated with any projections?"], "contexual_behavior": ["Are there signs that regenerative capacity is impaired, such as lack of recovery after injury due to stem cell dysfunction or chronic inflammation?", "Can you identify areas where immune defense in the gut appears reduced, possibly due to loss of immune cells or compromised mucosal immunity?", "Do any structures appear to have diminished enzyme secretion, potentially reflecting enterocyte dysfunction or chronic disease?"], "functions": ["Is there evidence of impaired mucosal immune defense or increased antigen penetration in the intestinal tissue?", "Can you identify features that suggest impaired nutrient absorption or disruption of the epithelial surface?", "Are there signs of altered fluid balance, such as features that could be associated with diarrhea or edema?"]}}, "adrenal capsule": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears thickened, which could suggest chronic inflammation, fibrosis, or the presence of a tumor?", "Can you identify a region that seems thinner than usual, potentially indicating atrophy or the effects of prolonged corticosteroid therapy?", "Does the image show evidence of calcification in a capsule-like structure, possibly related to old hemorrhage, tuberculosis, or metastatic disease?", "Is there a visible change in color of a capsule that might be due to hemorrhage, necrosis, or pigment deposition?", "Can you see fibrotic changes in a capsule, which could result from chronic injury, autoimmune adrenalitis, or long-standing inflammation?", "Is there a capsule displaying nodular formations, suggesting nodular hyperplasia or a neoplastic process?", "Does any capsule-like area appear disrupted or lacking integrity, which could be due to trauma, infarction, or severe infection?", "Is there swelling or edema present in a capsule, possibly indicating acute inflammation or infection?", "Can you observe shrinkage of a capsule, which might be associated with chronic atrophy or prolonged corticosteroid exposure?", "Is there abnormal tissue deposition within a capsule, such as might be seen in amyloidosis, metastatic infiltration, or granulomatous disease?", "Does the capsule appear edematous, which could be a sign of acute inflammation, allergic reaction, or vascular compromise?", "Is there hardening of a capsule-like structure, potentially due to fibrosis, calcification, or chronic granulomatous disease?", "Can you identify areas where a capsule appears softened, possibly resulting from acute necrosis, liquefactive changes, or enzymatic digestion?", "Is there increased cellularity within a capsule, which could indicate inflammatory infiltrates, neoplastic invasion, or hyperplasia?", "Does the capsule show irregular texture, scarring, or signs of tumor infiltration?", "Is there evidence of hemorrhage within a capsule, potentially following trauma, coagulopathy, or adrenal vein thrombosis?", "Can you see any disruption of a capsule, possibly caused by direct injury, surgical intervention, or invasive tumors?", "Is there fat accumulation within a capsule, which might be related to aging, obesity, or a lipomatous tumor?", "Does the capsule show inflammatory changes that could be due to autoimmune adrenalitis, infection, or systemic inflammatory diseases?", "Is there a visible change in the composition of a capsule, such as fibrosis, calcification, or infiltration by abnormal cells?"], "properties": ["Is there a thin, fibrous structure enveloping a gland with a crescent or triangular shape?", "Can you identify a whitish or pale layer that conforms to the outer contour of a gland?", "Does the image show a firm, fibrous texture surrounding an organ?", "Is there a region with high density and compact connective tissue visible?", "Can you see a structure with high collagen content and low elastic fiber content?", "Is there a layer composed mainly of dense connective tissue rich in collagen fibers?", "Does the outermost part of the gland appear to have sparse fibroblasts and occasional smooth muscle cells?", "Can you identify a structure whose thickness appears to be very thin, possibly between 50 and 200 micrometers?", "Is there a region whose surface area matches that of the gland, typically between 4 and 6 square centimeters in adults?", "Does the image show a layer with low cellularity, primarily containing fibroblasts?", "Is there an area where the protein content is predominantly structural, such as collagen?", "Can you see a structure with moderate water content, consistent with connective tissue?", "Is there a visible component whose weight would be a small fraction of the gland, likely less than 0.1 grams?"], "relational": ["Does the image show a structure that is part of the endocrine system?", "Can you identify an outer boundary that surrounds the adrenal gland?", "Is there a visible layer that forms the outermost part of the adrenal cortex?", "Does the image contain a region composed primarily of dense connective tissue?", "Can you see a structure adjacent to both the adrenal cortex and periadrenal fat?", "Is there a layer located in the suprarenal region of the abdomen?", "Does the image show a structure that receives blood supply from branches of the superior, middle, and inferior suprarenal arteries?", "Can you identify an area containing collagen fibers and fibroblasts?", "Is there a structure positioned near the kidney and diaphragm?", "Does the image reveal a boundary above the zona glomerulosa of the adrenal cortex?"], "contexual_behavior": ["Does the image show a structure whose extracellular matrix or cellular integrity appears disrupted, as might occur during inflammation?", "Is there evidence of impaired structural support, such as fibrosis or degradation, that could result from immune cell infiltration in autoimmune disease?", "Can you identify a region where altered permeability or changes in cellular junctions might suggest prolonged exposure to stress hormones?", "Does the image reveal compromised barrier function or loss of structural proteins that could be due to infection or the effect of inflammatory cytokines?", "Is there visual indication of thinning, reduced collagen content, or decreased cellular renewal that might be associated with aging?", "Can you see signs of structural failure or invasion that would allow expansion of an adjacent tumor beyond its usual boundaries?", "Is there evidence of increased susceptibility to damage, such as tears or weakness, that could result from trauma or pre-existing structural compromise?", "Does the image suggest developmental defects or impaired composition that might be seen in congenital adrenal disorders affecting protective function?", "Is there any indication of rupture, distension, or vascular injury that could be consistent with acute hemorrhage and increased intracapsular pressure?", "Can you observe changes in compartmentalization or barrier properties that might alter hormone diffusion in disease states?"], "functions": ["Does the image show a structure that serves as a protective outer layer for an endocrine gland?", "Is there a visible feature that provides physical support and separation from surrounding tissues for the adrenal gland?", "Can you identify a barrier that shields an adrenal structure from mechanical injury or infection?", "Does the image contain an enclosing layer that maintains the integrity of the adrenal gland's internal structures?", "Is there evidence of a selective barrier that could regulate the passage of molecules or cells into an adrenal region?", "Can you see a structure that helps preserve the specialized environment of the adrenal cortex by limiting external influences?", "Is there a layer that separates the adrenal cortex from adjacent tissues, supporting compartmentalization within the gland?", "Does the image show a feature that might participate in tissue repair or modulate inflammation in response to injury or stress around the adrenal gland?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image suggest that the hydrostatic pressure within small blood vessels is within the range of 25\u201330 mmHg or slightly elevated?", "Does the image show evidence of a pathological state characterized by unusually high permeability of small blood vessels?", "Can you identify a scenario where the thickness of the capillary walls appears normal, but their barrier function is compromised, leading to abnormal fluid and protein movement?"], "relational": ["Are there structural changes in capillaries, such as disrupted endothelial junctions or increased pore formation, visible in the image?", "Can you identify changes in connective, endothelial, or interstitial tissues that might indicate increased permeability?", "Are there signs of increased permeability in regions such as the skin, lungs, kidneys, or gastrointestinal tract?"], "contexual_behavior": [], "functions": ["Does the image display features that could be linked to complications of disease processes like sepsis, allergic reactions, or acute respiratory distress syndrome?", "Can you observe tissue characteristics that might be consistent with wound healing or tissue repair involving increased delivery of immune factors?", "Does the image show evidence of fluid accumulation in tissues that could indicate enhanced leakage of plasma components?"]}}}
[ { "answer": "multiple fractures", "extracted_concepts": [ "multiple fractures" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "multiple fractures" ], "question": "does this image show multiple fractures?" }, { "answer": "no", "extracted_concepts": [ "rheumatoid arthritis", "multiple fractures" ], "question": "does rheumatoid arthritis show multiple fractures?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "colon" ], "question": "is colon present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basilar skull fracture" ], "question": "is basilar skull fracture present?" }, { "answer": "no", "extracted_concepts": [ "coronary atherosclerosis" ], "question": "is coronary atherosclerosis present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" } ]	["multiple fractures", "bone", "coronary atherosclerosis", "rheumatoid arthritis", "colon", "calvarium", "basilar skull fracture"]	{"multiple fractures": {"yes_questions": {"contexual_properties": ["Is there evidence of increased swelling or edema in the region of acute injury?", "Can you identify areas where bone fragments appear displaced, suggesting instability from high-energy trauma?", "Does the image show abnormal angulation or malalignment at more than one bone site?", "Is there visible limb shortening or overlapping of bone fragments that could be due to muscle contraction or displacement?", "Are there signs of delayed bone healing, such as lack of bridging callus or persistent fracture lines, possibly due to poor vascularity or infection?", "Can you observe any visible deformity or malposition of a limb or bone immediately after injury?", "Is there evidence of increased local temperature or redness, indicating hyperemia during the acute inflammatory phase?", "Do you see changes in bone density, such as osteopenia or areas of callus formation, on the imaging?", "Is there visible bruising or ecchymosis in the soft tissues surrounding the injury site?", "Does the affected area appear to be associated with increased pain sensitivity or hyperalgesia, especially during movement?", "Can you detect abnormal or pathological mobility at one or more bone sites, suggesting instability or nonunion?", "Is there evidence of callus formation indicating the reparative phase of bone healing?", "Do you notice bone misalignment or displacement that could result from inadequate reduction or shifting of fragments?", "Are there changes in limb length, such as shortening, due to overriding bone fragments or bone loss?", "Does the imaging reveal abnormal radiographic features, such as multiple fracture lines or callus, at initial presentation or during healing?"], "properties": ["Does the image show evidence of two or more separate bone breaks?", "Can you identify bone fragments that are each between 2 and 10 centimeters in length?", "Is there visible displacement of bone fragments ranging from 1 to 5 centimeters?", "Does the gap between fractured bone ends appear to be approximately 1 to 3 centimeters wide?", "Can you observe swelling near the site of injury measuring about 3 to 8 centimeters in diameter?", "Is there any indication of blood loss that could be estimated between 500 and 2000 milliliters?", "Are the fractures located in the lower limbs, such as the femur or tibia?", "Do the bone breaks appear to be of transverse, oblique, or comminuted pattern?", "Is there visible angulation at the fracture sites between 10 and 30 degrees?", "Can you see signs of reduced bone density at the sites of injury, possibly below 0.8 g/cm\u00b2?", "Does the severity of the observed injuries appear moderate to severe?", "Is there any visual clue suggesting the affected individual is an adult between 20 and 50 years old?", "Are there signs of elevated tissue temperature around the injury, possibly between 37.5 and 39\u00b0C?", "Can you infer a high level of pain, potentially rated 7 to 10 out of 10, based on the visual presentation?", "Does the image suggest a healing process that might require 8 to 16 weeks depending on the extent and location of the injuries?"], "relational": ["Does the image show evidence of a pathological condition affecting the skeletal system in more than one location?", "Can you identify disruptions in the integrity of the musculoskeletal system involving multiple bones?", "Is there visual indication of injuries involving both the appendicular and axial skeleton?", "Does the image display abnormalities in long bones such as the femur, tibia, or humerus?", "Are there signs of injury in flat bones or the pelvis?", "Can you see affected regions in the limbs, spine, or skull that suggest more than one bone is involved?", "Is there involvement of joints such as the knee, hip, shoulder, or wrist adjacent to areas of bone disruption?", "Does the image show tissues like periosteum, muscle, ligament, tendon, or cartilage connected to visibly damaged bones?", "Are there features suggesting the participation of bone marrow or blood vessels in the healing process at multiple sites?", "Can you identify anatomical structures such as osteoblasts or periosteum that might be supporting repair in more than one area?", "Is there evidence that organ systems like the nervous, vascular, or integumentary systems are structurally impacted in association with bone injuries?", "Does the image show involvement of ligaments or tendons such as the anterior cruciate ligament, patellar tendon, rotator cuff tendons, or Achilles tendon near sites of bone disruption?"], "contexual_behavior": [], "functions": ["Does the image show evidence of structural instability or loss of integrity in more than one location?", "Can you identify signs of impaired function or complications that might arise from injuries affecting multiple sites?", "Is there visual indication of restricted mobility or the use of immobilization devices, such as casts or splints, on more than one limb?", "Does the image suggest reduced movement or the need for assistive support due to injuries at multiple sites?", "Can you observe features that might indicate delayed bone healing, such as abnormal alignment or persistent gaps at multiple injury sites?", "Is there evidence of nonunion or malunion in more than one bone, suggesting impaired healing processes?", "Does the image show signs that could be associated with a heightened inflammatory response, such as swelling or redness at multiple locations?", "Can you identify visual cues of vascular injury, such as bruising or pallor, that might indicate impaired blood flow to tissues?", "Is there evidence of tissue ischemia or impaired perfusion in areas affected by more than one injury?", "Does the image suggest disturbances in calcium or phosphate regulation, such as abnormal bone density or signs of bone resorption?", "Can you see indications that weight-bearing is limited, such as the use of crutches or avoidance of standing on certain limbs?", "Is there visual evidence of muscle weakness, atrophy, or impaired coordination in regions affected by multiple injuries?", "Does the image suggest an increased risk of fat embolism, such as the presence of long bone injuries with marrow exposure?", "Can you identify signs that tissue repair or regeneration may be impaired, such as persistent wounds or delayed closure at multiple sites?", "Is there evidence of a systemic metabolic response, such as muscle wasting or signs of increased energy expenditure, in the context of multiple injuries?", "Does the image suggest activation of the body's stress response, such as features consistent with acute distress or systemic physiological changes?"]}, "no_questions": {"contexual_properties": ["Can you observe cells with increased basophilic staining, which could indicate elevated RNA or ribosome content?", "Can you identify cells with increased cytoplasmic protein content, as seen during active secretion or synthesis of structural proteins?", "Is there evidence of lipid accumulation within the cytoplasm, as seen in metabolic disorders or fatty liver disease?"], "properties": ["Can you see a cell where the cytoplasmic density appears slightly greater than water?", "Does the cytoplasmic area of any cell appear granular, suggesting moderate to high granularity?", "Is there evidence of a cell with visible organelles such as mitochondria, endoplasmic reticulum, Golgi apparatus, or ribosomes?"], "relational": ["Does the image contain anatomical structures like the liver, salivary glands, or lymph nodes?", "Can you see structures that are part of the digestive, immune, or endocrine systems?", "Are there visible features suggesting the presence of organelles such as mitochondria, endoplasmic reticulum, Golgi apparatus, or ribosomes within the cells?"], "contexual_behavior": ["Can you see evidence of increased autophagic activity, such as cellular recycling, that might occur during starvation?", "Is there a cell region with enhanced energy production, such as increased glycolysis or mitochondrial activity, indicative of rapid proliferation?", "Is there a cellular structure with reduced support for division, potentially as a result of toxic exposure affecting cytoskeletal or metabolic processes?"], "functions": ["Does the image show a cell with features suggesting enhanced capacity for biosynthesis or metabolic activity?", "Does the image display a cell with sufficient space for optimal organelle maintenance and activity?", "Is there a cell present that might have an improved ability to respond to cellular stress due to cytoplasmic buffering capacity?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Is there an airway that looks narrowed or blocked, possibly due to mucosal swelling or bronchoconstriction from an allergic reaction?", "Does the image show a duct that appears progressively obstructed, possibly due to chronic disease with ongoing fibrosis or inflammation?", "Is there a passage that seems narrowed or blocked by plaque accumulation, indicating atherosclerotic occlusion?"], "properties": [], "relational": ["Can you identify a disruption in blood flow, bile drainage, air passage, or urine flow within the depicted structures?", "Is there a visible impact on the circulatory, respiratory, gastrointestinal, or renal system due to a non-patent component?", "Is there evidence of an organ such as the heart, lungs, kidneys, liver, or intestines containing a segment that is not open to flow?"], "contexual_behavior": ["Can you see signs of airway swelling or closure that might prevent effective ventilation and reduce oxygen delivery, as in anaphylaxis?", "Is there a lymphatic vessel that appears obstructed or fibrosed, potentially compromising lymphatic drainage and leading to lymphedema?", "Can you see a trachea that is blocked by a foreign body, which could prevent air movement to the lungs and result in ventilatory failure?"], "functions": ["Can you see any region where accumulation or deprivation of fluids or gases suggests impaired transport due to a physical barrier?", "Can you identify a region where blood flow seems to be impeded, possibly resulting in tissue ischemia or infarction?", "Is there visual evidence of tissue damage, inflammation, infection, or loss of function that could be due to a blocked anatomical pathway?"]}}, "coronary atherosclerosis": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a condition affecting the cardiovascular system?", "Can you identify any abnormalities in the left or right coronary arteries?", "Is there a visible change in the circumflex or left anterior descending artery?", "Are there any alterations in structures adjacent to the coronary arteries, such as the epicardium or myocardium?", "Does the image reveal any impact on the endothelium or smooth muscle within arterial walls?", "Is there a reduction in blood supply to regions like the left ventricle or interventricular septum?", "Can you observe signs of ischemia in the myocardial tissue?", "Are there visible changes in the intima, media, or adventitia layers of a coronary artery?", "Does the image show narrowing or plaque formation within an artery supplying the heart?", "Is there evidence of calcification within the coronary vessels?", "Can you identify any abnormalities in the marginal or diagonal branches of the coronary arteries?", "Are there signs that the cardiac conduction system or endocardium might be at risk due to compromised blood flow?"], "contexual_behavior": [], "functions": ["Does the image show evidence of narrowed arteries that could restrict blood flow to the heart muscle?", "Is there a visible reduction in the size of the arterial lumen that might impair oxygen delivery to cardiac tissue?", "Can you identify any features suggesting decreased elasticity or compliance in the coronary arteries?", "Does the image reveal signs of chronic inflammation or immune cell infiltration within the coronary vessels?", "Is there any indication of plaque buildup or thickening of the arterial wall that could contribute to disease progression?", "Can you see features that might suggest impaired vasodilation or dysfunction of the endothelium in the coronary arteries?", "Does the image show any evidence of thrombus formation or areas where plaque rupture may have occurred?", "Are there visual cues indicating smooth muscle proliferation or increased extracellular matrix within the vessel wall?", "Is there a sign of reduced coronary reserve, such as arteries that may not be able to dilate appropriately during increased oxygen demand?", "Can you identify any abnormalities that could lead to reduced myocardial perfusion or ischemia in the heart tissue?", "Does the image suggest a mismatch between coronary blood supply and the oxygen needs of the myocardium?", "Are there features present that could increase the risk of arrhythmias or impaired contractility in the heart?"]}, "no_questions": {"contexual_properties": ["Are erosions present that might be caused by NSAID injury or infectious colitis?", "Does the image reveal abnormal tissue growth such as neoplasms, polyps, or granulation tissue?", "Does the image show loss of the normal vascular pattern, possibly due to chronic inflammation or dysplasia?"], "properties": ["Is there any indication that the image format is JPEG, TIFF, DICOM, or MPEG?", "Can you tell if the illumination intensity in the image is within the range of 100,000 to 300,000 lux?", "Is there evidence of magnification in the image that could range from 1x to 20x?"], "relational": ["Is the visualized area part of a system like the digestive, respiratory, urinary, or reproductive system?", "Does the image show a cavity or lumen, such as a gastric lumen, colonic lumen, bronchial lumen, or bladder cavity?", "Are the boundaries of the visualized area defined by the mucosal surface, lumen boundary, or organ wall?"], "contexual_behavior": [], "functions": ["Can you identify any abnormalities such as lesions, tumors, or signs of inflammation in the internal tissues shown?", "Can you see visual cues that might help evaluate the effectiveness of a previous treatment or intervention?", "Does the image appear to guide or facilitate minimally invasive procedures by showing precise navigation of instruments within the body?"]}}, "rheumatoid arthritis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of joint swelling affecting between 4 and 10 joints?", "Can you identify signs of tenderness in 6 to 12 joints?", "Is there visible morning stiffness that appears to last longer than 60 minutes?", "Does the image display subcutaneous nodules in approximately 20 to 30% of the individuals shown?", "Are there radiographic features indicating mild to moderate joint erosions, with scores that might fall between 10 and 50 on the Sharp/van der Heijde scale?", "Can you observe any extra-articular manifestations present in about 40% of the depicted cases?", "Is there visual evidence suggesting a disease duration spanning 10 to 20 years?", "Does the image suggest the presence of anemia, with hemoglobin levels likely between 10 and 12 g/dL?", "Are there indications of elevated synovial fluid white blood cell counts, possibly ranging from 5,000 to 50,000 cells/\u03bcL?", "Can you infer that the average age of onset for the condition in the individuals shown is between 30 and 60 years?", "Is there evidence suggesting moderate to high disease activity, with a disease activity score (DAS28) likely between 3.2 and 5.1?"], "relational": ["Does the image show evidence of a condition affecting both the musculoskeletal and immune systems?", "Can you identify abnormalities in joints such as those of the hands, wrists, feet, or knees?", "Is there visible damage to structures like the synovial membrane, cartilage, ligaments, or bone within a joint?", "Does the image display chronic inflammation of the tissue lining a joint cavity?", "Are there signs of connective tissue involvement, such as changes in the synovium, tendons, or ligaments?", "Can you see structural alterations in bones such as the phalanges, metacarpals, or carpal bones?", "Is there evidence of joint deformity or bone erosions in the regions commonly affected by autoimmune processes?", "Does the image reveal features like synovial hyperplasia or cartilage erosion within a joint?", "Are there indications of an autoimmune process targeting joint tissues?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a cell with pale pink cytoplasm and dark purple nuclei under light microscopy?", "Is there a cell whose nuclei display finely dispersed, vesicular chromatin?", "Does the image show a cell with two large, mirror-image, vesicular nuclei?"], "relational": ["Can you observe alterations in lymph node architecture, germinal centers, or sinusoidal spaces?", "Can you see a cell with two large nuclei, prominent nucleoli, and abundant cytoplasm?", "Is there a cell present within the lymph node parenchyma that is pathognomonic for Hodgkin lymphoma?"], "contexual_behavior": [], "functions": ["Does the image suggest the presence of pro-inflammatory cytokine secretion, indicated by the recruitment of various immune cells?", "Can you see signs of an altered tumor microenvironment, such as an accumulation of inflammatory cells or an immunosuppressive milieu?", "Can you identify cells that might be suppressing immune responses or recruiting inflammatory cells in their vicinity?"]}}, "colon": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify regions such as the ascending, transverse, descending, or sigmoid segments within the image?", "Is there a structure that appears adjacent to the small intestine or rectum?", "Can you see any anatomical features located near the kidneys or bladder?", "Does the image contain vessels that could correspond to the superior or inferior mesenteric arteries supplying a digestive organ?", "Is there evidence of innervation by the enteric nervous system or by fibers from the vagus or pelvic splanchnic nerves in any visible structure?", "Can you identify a region that is continuous with the rectum at its terminal end?", "Is there a visible junction where the ileum meets a larger tubular structure, possibly involving the ileocecal valve?", "Does the image show a wall composed of multiple layers such as mucosa, submucosa, muscularis propria, and serosa?", "Are there lymphatic structures present, such as mesenteric or colic lymph nodes, associated with a tubular digestive organ?", "Can you identify anatomical boundaries such as the ileocecal junction or rectosigmoid junction in the image?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for absorbing water from digested food?", "Can you identify an area involved in regulating electrolyte levels, such as sodium and chloride absorption?", "Is there a region where undigested carbohydrates might be fermented by anaerobic bacteria?", "Does the image contain a structure that compacts waste material and stores it until elimination?", "Can you see evidence of an environment that supports the proliferation of beneficial gut microbiota?", "Is there a visible area where vitamins like vitamin K and B vitamins could be absorbed after being synthesized by resident bacteria?", "Does the image show a structure that propels fecal matter toward the rectum for excretion?", "Can you identify a region involved in maintaining fluid balance through water and electrolyte reabsorption?", "Is there a structure present that contributes to immune defense via gut-associated lymphoid tissue or antimicrobial peptide production?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an opening located centrally at the base of the occipital bone in the image?", "Does the image suggest developmental variation in the size of the central skull base opening, such as differences between infants and adults?", "Can you identify an opening with a width between 27 and 30 millimeters?"], "relational": ["Does the image show attachment points for the tectorial membrane or alar ligaments?", "Does the image include vascular structures such as the anterior or posterior spinal arteries near a large cranial opening?", "Is there a visible connection between the cranial cavity and the vertebral canal?"], "contexual_behavior": ["Are there features of bone weakening or degeneration at the skull base that might reduce structural protection for neural elements?", "Can you detect features suggestive of craniovertebral instability, possibly related to connective tissue disorders?", "Does the image reveal a mass or lesion at the skull base that might compress the spinal cord?"], "functions": ["Is there a visible feature that permits neural tissue to pass from the brainstem into the spinal cord?", "Does the image contain an opening that supports the transition of motor and sensory tracts from the brain to the spinal cord?", "Is there an anatomical feature that physically links the intracranial and spinal neural compartments, supporting central nervous system connectivity?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Is there an increased presence of apoptotic cells that could be due to cellular stress, toxic injury, or therapy response?", "Does the image reveal areas of decreased cellularity as seen in aplastic anemia, atrophy, or fibrosis?", "Are there visible clusters of inflammatory cells indicating acute or chronic inflammation or an immune response?"], "properties": ["Does the image show cells such as epithelial, connective tissue, muscle, or nerve cells?", "Is there evidence that the tissue section is cut to a thinness between 4 and 10 micrometers?", "Does the image appear to be captured at a magnification between 40x and 1000x?"], "relational": ["Does the image allow for the distinction between simple and stratified epithelium?", "Does the image display microscopic details that reveal the organization of tissues within an organ system such as the nervous or muscular system?", "Can you identify hierarchical levels such as cells, tissues, and organs within the image?"], "contexual_behavior": ["Are there features such as fibrosis, atrophy, or reduced cellularity that would suggest decreased tissue function due to aging?", "Can you identify disrupted tissue architecture or impaired cellular organization that could be associated with chronic inflammation?", "Are there increased mitotic figures or atypical nuclei in epithelial layers, suggesting heightened mitotic activity in precancerous lesions?"], "functions": ["Can you detect features indicating tissue plasticity or a stress response in the sample?", "Can you observe morphological changes that might indicate tissue dynamics or remodeling?", "Can you identify features that reveal the overall architecture of the tissue?"]}}, "basilar skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a fracture involving the base of the skull, particularly in bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Is there a fracture line at the cranial base that appears less than a few millimeters wide?", "Does the image reveal a break limited to the thickness of the cranial base bones, typically only a few millimeters deep?", "Can you see a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Is there a lucent line traversing the base of the skull visible on the image?", "Does the image show an air-fluid level or evidence of pneumocephalus near the base of the skull?", "Can you identify any signs of cerebrospinal fluid leakage in association with a skull base fracture?", "Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Does the image suggest a unilateral fracture at the base of the skull, rather than a bilateral one?", "Is the temporal bone involved in the observed skull base fracture?", "Can you estimate whether the displacement of the fracture at the skull base is minimal, less than 2 millimeters?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?", "Are there air-fluid levels present near the base of the skull, as seen in about 20% to 30% of such fractures?", "On CT imaging, is there a hypodense (lucent) line at the base of the skull relative to the surrounding bone?", "Can you observe bruising patterns such as blue or purple discoloration behind the ear or around the eyes, which may change to yellow-green as they resolve?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Can you identify abnormalities in the anterior, middle, or posterior cranial fossae?", "Is there any indication of injury near the course of cranial nerves like the olfactory, optic, or facial nerves?", "Does the image reveal changes involving foramina such as the foramen magnum or cribriform plate?", "Are there visible alterations adjacent to the inner ear, nasal cavity, or orbit?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?", "Is there evidence of communication between the cranial cavity and spaces such as the subarachnoid space or paranasal sinuses?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Are there signs of disruption in sinuses such as the sphenoid or ethmoid sinus?", "Can you identify exposure or compromise of anatomical pathways like cerebrospinal fluid pathways or the auditory canal?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a disruption in the structural integrity of the skull base that could compromise brain protection?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Can you identify features suggesting a breach between the nasal cavity and cranial cavity, such as a defect in the cribriform plate?", "Does the image reveal any signs that could explain cranial nerve deficits, such as those affecting facial movement, hearing, vision, or swallowing?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?", "Can you see any indications that might increase the risk of infection entering the central nervous system, such as a direct pathway for pathogens?", "Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Are there features present that could facilitate the development of a cerebrospinal fluid leak due to openings in the dura mater or bone?", "Is there any sign of functional impairment, such as altered consciousness, seizures, or focal neurological deficits, that could be explained by a structural abnormality at the skull base?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an area where the nuclear-to-cytoplasmic ratio is increased due to larger nuclei?", "Is there a region where the normal layering of cells is disrupted and tissue organization is lost?", "Does the image show an area with more than two layers of cells, exceeding the normal single or double layer?"], "relational": ["Is there a visible boundary defined by the basement membrane or a clear interface with normal tissue?", "Can you identify a region that is juxtaposed to, or appears to transition from, adjacent normal tissue?", "Does the image show an abnormal area originating from epithelial, glandular, or mucosal tissue?"], "contexual_behavior": ["Is there evidence of reduced DNA repair capacity in response to genotoxic stress, perhaps due to mutations in DNA repair genes?", "Can you identify an area where differentiation appears impaired, potentially associated with chronic inflammation or persistent cytokines?", "Is there a region where normal tissue architecture is disrupted, potentially due to loss of cell polarity or adhesion molecules?"], "functions": ["Can you identify areas where local immune responses might be modulated, such as regions with increased inflammatory cells or altered cytokine profiles?", "Can you identify a region that might serve as an early indicator for disease progression toward invasive cancer?", "Is there evidence of atypical cellular proliferation or altered differentiation without signs of tissue invasion?"]}}}
[ { "answer": "tumor", "extracted_concepts": [ "tumor" ], "question": "what grew to outside?" }, { "answer": "yes", "extracted_concepts": [ "tumor" ], "question": "is tumor grew to outside?" }, { "answer": "no", "extracted_concepts": [ "inflamed exocervix" ], "question": "is inflamed exocervix grew to outside?" }, { "answer": "view of head with huge ulcerated mass where tumor grew to outside", "extracted_concepts": [ "huge ulcerated mass", "head", "tumor" ], "question": "what does this image show?" }, { "answer": "with huge ulcerated mass where tumor grew to outside", "extracted_concepts": [ "ulcerated mass", "head", "tumor", "view of head" ], "question": "how does this image show view of head?" }, { "answer": "yes", "extracted_concepts": [ "huge ulcerated mass", "head", "tumor" ], "question": "does this image show view of head with huge ulcerated mass where tumor grew to outside?" }, { "answer": "no", "extracted_concepts": [ "head", "view of head", "cephalohematoma", "ulcerated mass", "tumor" ], "question": "does cephalohematoma show view of head with huge ulcerated mass where tumor grew to outside?" }, { "answer": "maxillary sinus", "extracted_concepts": [ "maxillary sinus" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "maxillary sinus" ], "question": "is maxillary sinus present?" }, { "answer": "no", "extracted_concepts": [ "test tube", "pus" ], "question": "is pus in test tube present?" }, { "answer": "squamous cell carcinoma", "extracted_concepts": [ "squamous cell carcinoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "squamous cell carcinoma" ], "question": "is squamous cell carcinoma present?" }, { "answer": "no", "extracted_concepts": [ "micrognathia", "triploid fetus" ], "question": "is micrognathia triploid fetus present?" }, { "answer": "tumor", "extracted_concepts": [ "tumor" ], "question": "what grew to outside?" }, { "answer": "maxillary sinus", "extracted_concepts": [ "maxillary sinus" ], "question": "what is present?" }, { "answer": "squamous cell carcinoma", "extracted_concepts": [ "squamous cell carcinoma" ], "question": "what is present?" } ]	["maxillary sinus", "head", "view of head", "triploid fetus", "test tube", "inflamed exocervix", "huge ulcerated mass", "cephalohematoma", "micrognathia", "squamous cell carcinoma", "ulcerated mass", "tumor", "pus"]	{"maxillary sinus": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the respiratory system and is surrounded by the maxilla?", "Can you identify a cavity adjacent to the nasal cavity, orbit, or upper teeth roots?", "Is there a space that connects to the nasal cavity through an opening in the middle meatus?", "Does the image contain a region whose walls are formed by the maxillary bone, orbital floor, alveolar process, or lateral nasal wall?", "Can you see an anatomical space that communicates with the nasal cavity via a specific ostium?", "Is there a structure associated with the infraorbital nerve or superior alveolar nerves?", "Does the image show an area supplied by the infraorbital artery or branches of the maxillary artery?", "Can you identify a cavity lined by pseudostratified ciliated columnar epithelium, also known as respiratory mucosa?", "Is there a paranasal sinus visible that is related to the frontal, ethmoid, or sphenoid sinuses?"], "contexual_behavior": [], "functions": ["Does the image show an air-filled cavity that helps reduce the weight of the skull?", "Can you identify a structure that contributes to humidifying and warming inhaled air by providing a moist mucosal surface?", "Is there a cavity present that could amplify or modify sound vibrations during speech?", "Does the image contain a space lined with mucosa that produces mucus and facilitates its drainage into the nasal cavity?", "Can you see a structure that aids in trapping and clearing airborne particles or pathogens before they reach the lower airways?", "Is there evidence of a cavity that participates in regulating pressure within the nasal cavity by allowing air exchange?", "Does the image include a region that supports immune defense by housing immune cells and producing antimicrobial substances?", "Can you identify a feature that plays a role in mucociliary clearance and respiratory protection?", "Is there a visible ostium that could facilitate air exchange and pressure equilibrium with the atmosphere?"]}, "no_questions": {"contexual_properties": ["Can you observe a head whose size appears disproportionate to the body, possibly suggesting a recent growth spurt or unresolved swelling?", "Does the head show discoloration that could be consistent with bruising, infection, or vascular malformations?", "Is there evidence of cranial shape changes that might be associated with craniosynostosis, trauma, or developmental disorders?"], "properties": [], "relational": ["Is there evidence of connective or epithelial tissue forming part of a prominent structure?", "Does the image show pathways for the optic or olfactory nerves?", "Can you identify an area that includes the scalp and jaw?"], "contexual_behavior": [], "functions": ["Does the image suggest atypical neurological development, such as differences in cognitive or motor skills?", "Can you observe signs that might indicate enhanced physical protection for the brain, such as increased skull thickness?", "Does the image show an individual with features suggesting increased cranial volume?"]}}, "head": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with an ovoid or ellipsoid shape?", "Can you identify an object whose size could be approximately 22 cm in length and 17 cm in width in adults?", "Is there a structure present that might weigh around 4.5 to 5 kg in an adult?", "Can you see something with a circumference likely between 54 and 58 cm?", "Does the image contain an object with an estimated volume of about 1.3 to 1.5 liters?", "Is there a visible area where the skin color ranges from pale to dark brown depending on pigmentation?", "Can you identify a region where the bone density could be around 1.5 to 2.0 g/cm\u00b3?", "Is there a structure that might contain about 70% water by weight?", "Can you see an area where fat content could account for 10% to 15% of total weight?", "Does the image show a region where the scalp thickness is likely between 5 and 7 mm?", "Is there a structure composed of bone, muscle, skin, nervous tissue, connective tissue, and adipose tissue?", "Can you identify an area where the temperature would be approximately 36.5 to 37.5\u00b0C?", "Does the image show a region with dense hair, possibly 200 to 300 hairs per cm\u00b2?", "Is there a structure that could contain minerals such as calcium, phosphorus, and magnesium in its bony component?", "Can you see an area where the skin pH might be between 4.5 and 5.5?", "Is there a structure that could be made up of 22 bones in an adult?", "Can you identify a region with high oxygen consumption, likely due to brain metabolism?", "Does the image show an area with a high concentration of sensory receptors, especially in the lips or tongue?", "Is there a structure that receives significant blood flow, approximately 750 ml/min?", "Can you see a region where the proportion of gray to white matter might be about 1.3:1?"], "relational": ["Does the image show a region containing components of the nervous system?", "Is there a structure present that includes elements of the musculoskeletal system?", "Can you identify an area that contains organs of the sensory system?", "Does the image include any part of the respiratory or digestive systems within a single region?", "Are there visible bones such as the cranium, mandible, or maxilla?", "Can you see features corresponding to the zygomatic, nasal, or temporal bones?", "Is there a region that includes the occipital, parietal, or frontal bones?", "Does the image show a compartment that could contain the brain?", "Are there visible structures corresponding to the eyes, ears, or nose?", "Can you identify an area that might contain the tongue or salivary glands?", "Is there a region that could be classified as the cranial cavity, facial region, or oral cavity?", "Does the image show an area that could be the nasal or orbital cavity?", "Are there muscles present such as the masseter, temporalis, or frontalis?", "Can you see features corresponding to the orbicularis oculi, orbicularis oris, or buccinator muscles?", "Is there evidence of nerves such as cranial nerves, trigeminal nerve, or facial nerve passing through this region?", "Does the image show structures that could be innervated by the optic, olfactory, glossopharyngeal, or vagus nerves?", "Are there visible blood vessels such as the carotid arteries, vertebral arteries, or jugular veins?", "Can you identify arteries like the facial artery or superficial temporal artery in the region?", "Is there a connection to the neck via structures such as the atlanto-occipital joint or foramen magnum?", "Does the image show features that could be associated with cervical vertebrae or neck muscles?", "Are there sensory organs such as the eyes, ears, nose, or tongue present in the region?", "Can you see cavities such as the cranial cavity, nasal cavity, oral cavity, or orbital cavity?", "Is there evidence of the middle ear cavity or paranasal sinuses in the image?"], "contexual_behavior": ["Does the image show a structure that would exhibit reduced sensory processing during sleep in the NREM stages?", "Is there evidence of impaired coordination that could result from disrupted neural pathways after a traumatic injury?", "Can you identify a region where increased blood flow might occur during cognitive activity to meet metabolic demands?", "Does the image contain a structure that could lose its ability to regulate temperature in the event of heatstroke due to hypothalamic dysfunction?", "Is there a feature that could experience altered pain perception during a migraine as a result of trigeminovascular pathway sensitization?", "Can you see an area where neural activity would decrease under anesthesia due to suppressed central nervous system signaling?", "Is there a structure that might fail to maintain balance after vestibular dysfunction involving the inner ear or brainstem pathways?", "Does the image show a region where intracranial pressure could increase during infection as inflammation and edema develop?", "Is there a part that could demonstrate impaired speech production after a stroke affecting language centers?", "Can you identify an area that would show reduced oxygen supply in hypoxic conditions when arterial oxygen levels fall?", "Is there a structure that might alter its sensory integration during sensory overload due to overstimulated neural circuits?", "Does the image show a region that could experience diminished reflex responses as neuronal degeneration progresses in neurodegenerative disease?", "Is there a part that would increase metabolic demand during mental stress as neuronal activity and glucose consumption rise?", "Can you see evidence of impaired eye movement coordination that could result from disruption of oculomotor pathways after concussion?", "Is there a region that could show impaired thermoregulation in hypothalamic disorders when temperature control centers are affected?"], "functions": ["Does the image show a structure that houses multiple sensory organs such as those for vision, hearing, smell, taste, or touch?", "Can you identify a region that protects a major neural organ within a bony cavity?", "Is there a part visible that enables communication through speech or facial expressions?", "Does the image contain structures responsible for sensory integration, such as eyes, ears, nose, tongue, or skin?", "Can you see evidence of a bony structure that safeguards neural tissue?", "Is there a region that facilitates feeding and swallowing by coordinating the mouth, jaws, tongue, or pharynx?", "Does the image include features associated with balance and orientation, such as the vestibular system or inner ear?", "Can you identify an area that assists with breathing or olfaction by containing a nasal cavity or respiratory passages?", "Is there a structure that enables facial expression via the action of muscles controlled by cranial nerves?", "Does the image show components involved in hearing, such as the auricle, tympanic membrane, or cochlea?", "Can you see organs responsible for vision and eye movement, including extraocular muscles or the optic nerve?", "Is there evidence of taste sensation through the presence of a tongue or palate?", "Does the image reveal structures that contribute to speech production, such as the larynx, vocal cords, tongue, lips, or jaw?"]}, "no_questions": {"contexual_properties": ["Is there evidence of altered tissue composition, such as changes from metabolic processes, infiltration by foreign cells, or fibrosis?", "Is there evidence of abnormal material buildup, like amyloid deposits, fat accumulation, or iron overload?", "Does the image show a region with color changes that might indicate hemorrhage, necrosis, or a pigmentation disorder?"], "properties": ["Does the image include an object that would typically be at a temperature of about 37\u00b0C in the human body?", "Can you identify an object with a density close to 1.05 to 1.10 grams per cubic centimeter?", "Is there a structure present with mineral content less than 1% by weight, possibly including sodium, potassium, or calcium ions?"], "relational": ["Can you identify any object for which the relationship to secondary structures cannot be described?", "Does the image include any region where connected vessels or ducts are not identifiable due to insufficient context?", "Is there a structure whose interactions with organ systems are indeterminate due to lack of anatomical clarity?"], "contexual_behavior": ["Does the image suggest altered behavior of a biological structure, potentially as a response to metabolic disturbances?", "Is there evidence in the image of a tissue whose main function appears impaired, possibly due to pathological changes?", "Does the image show a system with accelerated activity, which could indicate activation during acute illness?"], "functions": ["Can you identify features that indicate the performance of core activities essential for organ function and systemic health?", "Does the image show cells presenting antigens or interacting with immune cells, suggesting involvement in immune responses?", "Is there evidence of cells performing tasks such as secretion, absorption, or contraction depending on their type?"]}}, "view of head": {"yes_questions": {"contexual_properties": ["Is there evidence of swelling that could suggest trauma, infection, or an allergic reaction?", "Can you identify any areas of discoloration that might indicate bruising, cyanosis, or jaundice?", "Does the image show asymmetry that could be related to a congenital anomaly, tumor, or previous injury?", "Is there a noticeable abnormality in size that could be consistent with macrocephaly, microcephaly, or hydrocephalus?", "Can you see any deformities that might be associated with craniofacial syndromes, trauma, or developmental disorders?", "Is there visible bruising that could result from blunt force, a fall, or a coagulopathy?", "Does the image reveal changes in contour that might be due to a mass, edema, or a bone abnormality?", "Are there any visible masses or lumps that could represent a cyst, tumor, or abscess?", "Can you observe any skin changes that might be due to a dermatological condition, infection, or inflammation?", "Is there an area with abnormal texture that could be explained by scarring, edema, or a dermatological disorder?", "Does the image show evidence of hair loss that might be related to alopecia, a fungal infection, or an autoimmune disease?", "Is there increased redness that could suggest cellulitis, erythema, or an allergic reaction?", "Can you see pallor that might be associated with anemia, shock, or vascular insufficiency?", "Are there abnormal surface features such as lesions, ulcers, or congenital malformations present?", "Is there visible edema that could be due to an allergic reaction, infection, or heart failure?"], "properties": ["Does the image display a region with an oval or rounded shape that matches the typical contours of the human head?", "Can you identify anatomical landmarks such as the skull, orbits, nasal cavity, mandible, or cranial sutures in the image?", "Is the orientation of the image consistent with axial, coronal, or sagittal planes commonly used in medical imaging?", "Does the image appear to be captured in the axial plane, as is standard for this type of view?", "Is the spatial resolution of the image sufficient to distinguish features at the millimeter scale, typically between 0.3 mm and 1 mm per pixel?", "Can you observe differentiation between soft tissue, bone, and air spaces, indicating appropriate contrast levels in the image?", "Is the brightness of the image optimized to clearly visualize anatomical structures?", "Does the field of view encompass the entire cranium and facial bones, covering an area approximately 18\u201325 centimeters in size?", "Is the image presented in grayscale, or does it use color representation as seen in some imaging modalities?", "Does the pixel density appear to be around 1\u20132 pixels per millimeter, providing adequate spatial sampling?", "Is the aspect ratio of the image close to 1:1, suggesting a square format?", "Does the scale or magnification of the image correspond to life-size or a 1:1 anatomical scale?", "If the image is cross-sectional, is the slice thickness between 1 and 5 millimeters as is typical for this type of view?", "Does the anatomical coverage in the image include the entire skull, facial bones, and soft tissues of the head?", "Is the image size within the typical range of 512x512 to 1024x1024 pixels?"], "relational": ["Does the image display a region that includes both cranial and facial areas?", "Can you identify bones such as the frontal, parietal, or zygomatic in the image?", "Is there evidence of structures like the maxilla or mandible present?", "Does the image contain organs such as the brain, eyes, or oral cavity?", "Are sensory structures like the ears or nose visible?", "Can you see muscles such as the masseter or temporalis in the depicted region?", "Is there a visible feature corresponding to the orbicularis oculi or orbicularis oris?", "Does the image show blood vessels such as the superficial temporal artery or facial artery?", "Can you identify any veins or arteries like the external jugular vein or internal carotid artery?", "Are nerves such as the facial or trigeminal nerve represented in the image?", "Is there a visible indication of the optic or olfactory nerve?", "Does the image include cavities like the cranial, nasal, or orbital cavity?", "Can you see the oral cavity or any of its boundaries?", "Are tissues such as bone, muscle, or nervous tissue observable in the depicted area?", "Is there evidence of connective or epithelial tissue in the region shown?", "Does the image contain anatomical landmarks such as the hairline, chin, or jaw angle?", "Can you identify the zygomatic arch, supraorbital margin, or mastoid process in the image?", "Is there a region defined by both the cranial cavity and the facial region present?", "Does the image show taste buds or structures associated with taste sensation?"], "contexual_behavior": ["Does the image show a situation where sensory input might be reduced due to visual impairment such as cataracts or retinal disease?", "Is there evidence of altered head orientation that could be related to balance disturbances like vertigo or vestibular dysfunction?", "Can you observe a change in the field of vision that might result from head rotation or eye movement?", "Does the image suggest a restricted field of view that could be associated with neurological disorders such as stroke or multiple sclerosis?", "Is there an indication that head position is being adjusted to compensate for vestibular dysfunction and stabilize gaze?", "Can you see signs of gaze maintenance during rapid movement, possibly reflecting the vestibulo-ocular reflex?", "Does the image include features that might indicate impaired vision following traumatic injury to the brain, eyes, or cranial nerves?", "Is there visual evidence of adaptation to low-light conditions, such as increased retinal sensitivity or pupil dilation?", "Can you detect a narrowed field of view that might be associated with migraine aura or transient visual disturbances?", "Does the image suggest realignment of gaze and head position to maintain equilibrium during motion sickness?", "Is there a sign of altered awareness of one side of space, possibly indicating spatial neglect syndrome?", "Can you observe changes in head or eye direction that might occur during visual field testing?", "Is there evidence of image instability that could be due to involuntary eye movements, such as nystagmus?", "Does the image suggest an expanded field of view or increased visual attention, as might occur during heightened alertness?", "Can you see limitations in the field of vision that could result from swelling or inflammation affecting the eyes, eyelids, or surrounding tissues?"], "functions": ["Can you identify any anatomical structures in the head region that would be relevant for clinical evaluation?", "Does the image provide enough visual information to assess for pathological changes in the head?", "Is there evidence of cranial nerve function or abnormal head posture observable in the image?", "Can you detect any abnormal movements that might indicate a neurological condition?", "Does the image reveal any signs of cranial trauma, such as deformities, lacerations, or hematomas?", "Is there visible asymmetry when comparing bilateral facial features?", "Can you observe any fractures, depressions, or abnormal contours in the skull?", "Does the image allow for identification of cranial or facial anatomical landmarks useful for surgical planning?", "Is there any indication of swelling, changes in mass size, or deformity that could be monitored over time?", "Can you visually inspect the scalp, face, jaw, or cervical regions for abnormalities?", "Are there any abnormal contours, asymmetry, or visible lumps suggesting soft tissue swelling or masses?", "Does the image enable rapid identification of external injuries, bleeding, or deformities in the head region?"]}, "no_questions": {"contexual_properties": ["Are there cystic changes visible, possibly due to fibrocystic alterations or benign cyst formation?", "Does the tissue appear denser, which might be related to fibrocystic changes, hormonal stimulation, or neoplasia?", "Is there visible swelling that might suggest inflammation, infection, or malignancy?"], "properties": ["Does the image suggest a molecular subtype such as luminal A, luminal B, HER2-enriched, or triple negative?", "Does the image suggest that hormone receptor status, such as estrogen or progesterone positivity, could be relevant for this lesion?", "Can you assess whether the pathological grade of the lesion appears to be low, intermediate, or high?"], "relational": ["Does the image reveal any changes in the lactiferous ducts, terminal duct lobular units, or major lobules?", "Is there any sign of invasion or alteration of the pectoralis major muscle or the overlying skin?", "Are there visible changes in lymphatic structures such as the axillary, internal mammary, or supraclavicular lymph nodes?"], "contexual_behavior": ["Is there evidence that the breast\u2019s response to environmental toxins might be altered, such as tissue changes linked to genetic alterations, inflammation, or neoplasia?", "Is there a visible indication of impaired immune defense in breast tissue, possibly due to inflammation or malignancy?", "Can you identify alterations in the vascular supply to breast tissue, such as compressed or invaded blood vessels?"], "functions": ["Is there a visible change in texture, lump formation, or alteration in the appearance of the skin or nipple?", "Can you identify any signs of decreased milk production or obstruction of glandular ducts in the relevant area?", "Can you see localized redness, warmth, or swelling that might indicate an enhanced inflammatory process?"]}}, "test tube": {"yes_questions": {"contexual_properties": ["Is there an object in the image that appears discolored, possibly due to exposure to chemicals or heat?", "Can you identify a structure that shows residue buildup, suggesting incomplete cleaning or evaporation of solutions?", "Does the image contain an item with visible cracks, which could result from mechanical stress or rapid temperature changes?", "Is there an object whose weight might have changed after use because of remaining residues or evaporation?", "Can you see a structure that looks cloudy, potentially due to deposition of insoluble materials or surface etching?", "Does any object in the image show accumulation of precipitate from a chemical reaction?", "Is there a structure with altered transparency, possibly caused by internal deposits, scratches, or chemical reactions?", "Can you identify an item with stains that may have resulted from chemical reactions producing colored byproducts?", "Does the image show a structure that could experience changes in internal pressure during heating or gas evolution?", "Is there an object that appears etched, possibly due to exposure to corrosive substances like strong acids or bases?", "Can you see contents that have changed color, perhaps due to a chemical reaction, pH shift, or indicator use?", "Is there a structure whose contents are separated into layers, indicating the presence of immiscible liquids or phases?", "Does the image contain an object with contents that have increased in volume, possibly from gas evolution, heating, or addition of reagents?", "Can you identify a structure whose contents have decreased in volume, perhaps due to evaporation, sampling, or chemical consumption?", "Is there an object whose contents appear more viscous, possibly as a result of concentration, polymerization, or precipitation?"], "properties": ["Does the image show an object with a cylindrical shape and a rounded bottom?", "Can you identify a structure that appears transparent or clear?", "Is there an object present that could have a volume capacity between 5 mL and 50 mL?", "Can you see something with a length likely between 75 mm and 150 mm?", "Is there a structure with a diameter in the range of 10 mm to 20 mm?", "Does the image contain an object that might be made from borosilicate glass, polypropylene, or polystyrene?", "Can you identify an object with a wall thickness of about 1 mm to 2 mm?", "Is there a structure that could weigh between 10 grams and 20 grams when empty?", "Does the image show an object with a smooth, flared rim?", "Can you see a structure with a labeling area approximately 20 mm by 40 mm?", "Is there an object that could withstand temperatures up to 500\u00b0C if made from borosilicate glass?", "Can you identify a structure that might exhibit high resistance to chemical corrosion?", "Does the image contain an object that could tolerate internal pressures up to about 1 atmosphere?", "Is there a structure whose melting point might be around 820\u00b0C if made from borosilicate glass?"], "relational": ["Does the image show an object commonly used in clinical chemistry or hematology procedures?", "Can you identify a container that might hold blood samples or reagents?", "Is there a vessel present that could contain culture media for microbiology?", "Does the image include an item that is typically supported by a rack or holder designed for cylindrical glassware?", "Can you see any racks, holders, or clamps that are used to support cylindrical laboratory containers?", "Is there a structure that could be placed in a centrifuge for sedimentation or separation by centrifugal force?", "Does the image show a process such as sample collection, mixing, incubation, or centrifugation involving a small cylindrical vessel?", "Can you identify glassware that is structurally similar to a culture tube or centrifuge tube?", "Is there a container with a closure such as a rubber stopper, screw cap, or plastic cap?", "Does the image show a device like a needle, syringe, or transfer pipette being used to transfer a specimen into a small cylindrical container?", "Is there a vessel that might contain anatomical samples such as blood, urine, or saliva?"], "contexual_behavior": ["Is there an object in the image whose ability to contain biological reactions could be compromised if exposed to extreme temperatures?", "Can you identify a vessel whose sterility might be affected by improper sealing or exposure to a non-sterile environment?", "Is there a container present that could have its function as a reaction vessel impaired by residual chemicals from previous uses?", "Does the image show an item whose capacity to support cell culture would decrease if its surface integrity were compromised by poor storage conditions?", "Is there a vessel in the image that could fail to preserve sample integrity if exposed to prolonged light, especially for photosensitive contents?", "Can you see an object whose role in separating blood components would depend on the speed of centrifugation, affecting the formation of distinct layers?", "Is there a container whose effectiveness in preventing evaporation might be reduced in a low humidity environment, leading to sample loss?", "Does the image include a vessel whose efficiency in mixing samples could be hindered by high viscosity solutions?", "Is there an object present whose ability to support enzymatic reactions would decrease if the pH level is not optimal for enzyme activity?", "Can you identify a vessel whose function in maintaining sample stability could be affected by rapid temperature changes, potentially causing condensation or denaturation?"], "functions": []}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see an organ with the adrenal gland positioned directly superior to it?", "Can you identify an organ located in the retroperitoneal space of the abdominal cavity?", "Is there a structure anatomically adjacent to the adrenal glands, liver, spleen, or intestines?"], "contexual_behavior": [], "functions": []}}, "inflamed exocervix": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the female reproductive system and projects into the vaginal canal?", "Is there an area adjacent to both the vagina and the endocervix visible in the image?", "Can you identify a region composed mainly of non-keratinized stratified squamous epithelium and underlying connective tissue?", "Does the image contain a portion of tissue that is contiguous with the endocervix at the squamocolumnar junction?", "Is there a structure that receives blood supply from branches of the uterine or vaginal arteries?", "Can you see a region whose lymphatic drainage is associated with parametrial, internal iliac, or obturator lymph nodes?", "Does the image include an outer portion of the cervix that is connected to both the uterus and the vagina?", "Is there a visible area that forms part of the cervical portio vaginalis?", "Can you identify a region that is part of the ectocervix and lies adjacent to the cervical canal?"], "contexual_behavior": ["Is there a region that appears to have reduced barrier function against pathogens, possibly indicating increased susceptibility to infection?", "Can you identify an area where secretion of inflammatory mediators or cytokine release might be occurring in response to tissue injury or microbial invasion?", "Does the image show evidence of impaired mucus production or gland dysfunction due to inflammation?", "Is there a structure that seems more susceptible to infection because of compromised epithelial integrity?", "Can you see any indication that the passage of sperm might be hindered due to altered mucus quality or changes in the cervical environment?", "Does the image suggest an altered or impaired healing response, possibly due to chronic inflammation interfering with tissue repair mechanisms?", "Is there visual evidence of increased recruitment of immune cells in response to tissue damage or infection?", "Can you identify an area where normal epithelial regeneration or cellular turnover appears disrupted by persistent inflammation?", "Does the image show signs of impaired tissue repair, such as ongoing tissue damage or chronic inflammatory changes?", "Is there evidence of increased vascular permeability, such as edema or leukocyte infiltration, associated with acute inflammation?", "Can you see any indication that protective function during menstruation might be reduced due to weakened epithelial barriers or immune defenses?", "Does the image suggest an altered response to hormonal changes, possibly due to disrupted hormone receptor signaling or tissue sensitivity?", "Is there a region that appears to have decreased resistance to mechanical stress, potentially due to weakened tissue structure from inflammation?", "Can you identify an area where enhanced cytokine release might be occurring as part of a local immune defense mechanism against infection?", "Does the image show signs of impaired cellular turnover, such as abnormal cell proliferation or differentiation, due to inflammatory processes?"], "functions": ["Does the image show a tissue that appears to be mounting a local immune response?", "Is there evidence of increased vascular permeability, such as swelling or redness, in any mucosal area?", "Can you identify a region where immune cells like neutrophils or macrophages might be recruited to the site of inflammation?", "Does any structure in the image display signs of epithelial disruption or compromised tissue integrity?", "Is there a visible increase in mucus production or changes in mucus appearance that could indicate altered mucin content?", "Can you see features suggesting the release of inflammatory mediators, such as localized redness or edema?", "Is there evidence of cellular infiltration that could reflect cytokine or chemokine activity?", "Does any area appear to be undergoing epithelial regeneration or tissue repair?", "Can you identify a region where antimicrobial activity might be enhanced, such as increased secretion or surface changes?", "Is there a structure that could be modulating its local microenvironment, for example by showing changes in pH-sensitive staining or altered cellular composition?", "Does the image show signs that pro-inflammatory mediators might be present, such as increased immune cell presence or tissue swelling?", "Is there evidence of antigen presentation, such as clusters of immune cells interacting with epithelial surfaces?"]}, "no_questions": {"contexual_properties": ["Does the image show areas where fat tissue appears disrupted or necrotic?", "Does the image display zones where fat cells are replaced by amorphous or granular material possibly due to necrosis?", "Are there visible features consistent with the formation of chalky or opaque deposits within areas of fat tissue?"], "properties": ["Can you detect regions that might have a slightly alkaline pH due to the presence of calcium soaps?", "Does the image contain areas that look firm and gritty, possibly due to calcification?", "Are there any chalky white or pale yellow structures visible?"], "relational": ["Can you identify an area where necrotic fat is bordered by a fibrous rim?", "Is there a region associated with hemorrhage, chronic inflammation, or granulomatous reaction?", "Does the image show a lesion in the breast or pancreas that is surrounded by fibrosis and contains calcified material?"], "contexual_behavior": ["Does the image contain structures that suggest the formation of soap-like material within fatty tissue?", "Are there visible signs of calcification within areas of fat necrosis?", "Is there evidence of tissue changes consistent with necrosis in adipose regions?"], "functions": ["Is there visual evidence of persistent irritation or delayed resolution of inflammation, suggesting a chronic inflammatory response?", "Does the image show evidence of a protective mechanism that localizes tissue injury and limits the spread of toxic substances?", "Are there features suggesting stabilization of fat breakdown products, such as saponification or reduced enzymatic degradation?"]}}, "huge ulcerated mass": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a lesion in the image that appears larger than 5 centimeters in diameter?", "Can you identify a structure with an irregular or lobulated shape?", "Does the image show an area with coloration ranging from red to grayish or necrotic yellow?", "Is there a mass with an uneven, friable, and ulcerated surface visible?", "Can you see evidence of deep ulceration extending several millimeters or centimeters into underlying tissue?", "Is there a structure that appears firm or hard with regions that look softer, possibly due to tissue breakdown?", "Does the image contain a mass that could weigh more than 100 grams based on its apparent size?", "Are there any lesions with raised, rolled, or undermined edges present?", "Can you observe exudate that appears serous, purulent, or hemorrhagic in nature?", "Is there a region with increased vascularity or prominent, fragile blood vessels?", "Does the image show extensive areas of dead or necrotic tissue?", "Is there any indication of a foul or putrid odor, such as visible signs of bacterial colonization or tissue breakdown?", "Can you identify a region that might feel warmer than the surrounding tissue, suggesting localized elevation in temperature?", "Is there evidence of a lesion composed of malignant or inflammatory cells, or containing necrotic debris?", "Does the surface of any visible mass suggest a slightly acidic to neutral environment, such as pH between 5.5 and 7.0?"], "relational": ["Does the image show a lesion that appears to originate from epithelial, connective, or muscle tissue?", "Is there a large abnormal area present in regions such as the skin, gastrointestinal tract, oral cavity, or breast?", "Can you identify a structure that is adjacent to surrounding soft tissue, blood vessels, or nerves?", "Is there evidence of invasion into organs like the liver, lung, bone, or intestine?", "Does the abnormal area involve multiple tissue layers such as the epidermis, dermis, subcutaneous tissue, or muscle layer?", "Are arteries, veins, or capillaries visible in association with the abnormal structure?", "Can you see regional lymph nodes or lymphatic vessels connected to the lesion?", "Is there a structure that could affect the integumentary, digestive, or musculoskeletal system?", "Are the margins of invasion, fascial planes, or involvement of adjacent organs visible in the image?", "Does the lesion contain areas that might represent malignant cells, inflammatory cells, necrotic cells, or fibroblasts?"], "contexual_behavior": ["Is there a structure in the image that appears to have disrupted epithelial surfaces, potentially exposing underlying tissue and increasing susceptibility to infection?", "Can you identify an area where tissue breakdown might result in increased fluid loss due to chronic ulceration and barrier dysfunction?", "Does the image show a region that could be producing increased exudate, possibly as a result of secondary infection and inflammation?", "Is there evidence of abnormal or excessive blood vessel formation, which might suggest angiogenesis in response to hypoxic conditions?", "Can you see signs of tissue necrosis that might impair local immune surveillance or function?", "Is there a visible lesion that appears prone to bleeding, possibly due to fragile vessels and tissue erosion under mechanical stress?", "Does the image contain a mass that could be associated with delayed healing, perhaps due to chronic inflammation, necrosis, or persistent infection?", "Is there a structure that might be experiencing increased metabolic activity or rapid growth, which could indicate malignant transformation?", "Can you identify a region where pain signaling might be increased, possibly due to inflammation and sensitization of local nerve endings?", "Is there an area that could be at risk for systemic inflammatory responses, especially if local inflammation has the potential to spread to the bloodstream?", "Does the image show a lesion that might heal slowly due to poor vascular supply and limited oxygen or nutrient delivery?", "Is there a region where infection could spread more easily in the context of immunosuppression, due to poor containment by immune cells?", "Can you see evidence of bacterial colonization that might increase the risk of sepsis if tissue barriers are breached?", "Is there a lesion that may have reduced capacity for re-epithelialization, particularly if the patient has diabetes and impaired cellular migration?"], "functions": ["Is there a structure in the image that appears to be causing extensive tissue destruction or chronic inflammation?", "Can you identify an area where healthy tissue seems to be replaced by necrotic or inflamed material, possibly resulting in loss of normal organ function?", "Does the image show evidence of a lesion compressing or invading blood vessels, which could lead to reduced blood flow or signs of ischemia?", "Is there a region that suggests persistent inflammation, vascular compromise, or widespread cell death?", "Can you see an area that might be exposed to pathogens or showing signs of ongoing cytokine release and chronic inflammation?", "Does the image contain a lesion that appears to maintain an open wound, possibly fostering infection or delaying healing?", "Is there visible evidence of bleeding or erosion of blood vessels within an ulcerated area?", "Can you identify a region where protective tissue barriers are breached, potentially increasing the risk of microbial entry and infection?", "Does the image show tissue loss or destruction of normal vasculature that could impair nutrient absorption or lead to malnutrition in the affected area?", "Is there a region with signs of immune cell infiltration or a chronic inflammatory microenvironment, suggesting altered local immunity?", "Can you see evidence of nerve involvement, such as exposed or inflamed tissue that might be associated with pain generation?", "Does the image reveal abnormal connections between structures, possibly indicating tissue erosion and fistula formation?", "Is there a region where lymphatic vessels appear obstructed, leading to local swelling or impaired drainage?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image reveal changes involving lobular epithelial cells?", "Is there a mass structurally related to mammary lobules or terminal ducts?", "Does the image show an abnormality originating from the epithelial tissue of mammary lobules?"], "contexual_behavior": [], "functions": []}}, "cephalohematoma": {"yes_questions": {"contexual_properties": ["Is there a swelling that appears to have increased in size shortly after birth, suggesting ongoing hemorrhage beneath the periosteum?", "Can you identify a mass that appears to be gradually decreasing in size, consistent with blood resorption over days to weeks?", "Is there a lesion whose color changes from red to yellow or green, indicating hemoglobin breakdown and bilirubin formation?", "Does the image show a mass that has become firmer, possibly due to clot organization and formation during the subacute phase?", "Can you see an area that appears softer or more fluctuant, which may indicate clot liquefaction or ongoing blood resorption?", "Is there evidence of calcification within a swelling, suggesting chronicity and incomplete blood resorption?", "Does the image reveal signs of infection such as redness, swelling, or pus over a localized mass?", "Can you observe overlying skin changes like erythema or ulceration that might result from infection or pressure necrosis?", "Is there a fluctuant mass present, possibly due to enzymatic breakdown of a clot and partial liquefaction?", "Does the image suggest a spontaneously resolving swelling, consistent with gradual blood reabsorption over several weeks?", "Is there a persistent mass that has not resolved within the expected timeframe, possibly due to calcification, ongoing bleeding, or impaired resorption?", "Can you identify a swelling with multiple lobes or irregular borders, which may indicate extension along suture lines or multilobulated hematoma?", "Is there a mass that appears to have increased in size following birth trauma, suggesting continued bleeding?", "Does the image show signs of neonatal jaundice that could be associated with the breakdown of red blood cells in a localized swelling?"], "properties": ["Is there a dome-shaped or ovoid swelling visible over the parietal region of the skull?", "Can you identify a bluish or purplish area beneath the periosteum of the parietal bone?", "Does the image show a soft, fluctuant swelling that could measure between 2 and 10 centimeters in diameter?", "Is there evidence of a subperiosteal accumulation that might contain clotted blood and plasma?", "Can you see a swelling whose size suggests a volume between 10 and 50 milliliters?", "Is there a structure present that would be expected to resolve within 2 to 6 weeks after birth?", "Does the image show a lesion whose density and water content are similar to those of blood?", "Is there a swelling that would likely have a temperature matching normal body temperature, around 36\u201337\u00b0C?", "Can you identify a structure that would be expected to have a high red blood cell concentration and low white blood cell count unless infected?", "Is there a swelling whose protein content would be similar to that of plasma, approximately 60\u201380 grams per liter?", "Does the image show a lesion located beneath the periosteum and confined to the parietal bone?"], "relational": ["Is there a swelling located between the periosteum and the skull bone, but not involving the more superficial layers of the scalp?", "Can you identify a collection that is limited by the margins of a single cranial bone, such as the parietal bone?", "Does the image show a subperiosteal accumulation that does not cross cranial bone sutures?", "Is there evidence of a lesion that is contained by the periosteum and does not extend beyond the boundaries of an individual cranial bone?", "Can you see a swelling that is most prominent over the parietal region of the skull?", "Is there a feature that could result from rupture of small blood vessels crossing the periosteum, such as emissary veins?", "Does the image show a scalp swelling that is anatomically distinct from more superficial conditions like caput succedaneum?", "Is there a collection located in the subperiosteal space of the scalp?", "Can you identify a swelling that is structurally related to, but distinct from, subgaleal hematoma or caput succedaneum?"], "contexual_behavior": ["Does the image show a scalp swelling that appears unusually large or tense, which might suggest delayed blood reabsorption or impaired scalp mobility?", "Is there evidence of skin breakdown or recent invasive procedures over a scalp swelling, indicating an increased risk of infection?", "Can you identify persistent swelling or signs of infection in the scalp area that could impair normal tissue healing?", "Does the image suggest the presence of jaundice in a newborn, possibly related to the breakdown of accumulated blood in a scalp swelling?", "Is there a scalp swelling that does not appear to be decreasing in size, which might indicate ongoing bleeding, infection, or impaired resorption?", "Can you see a scalp mass large enough to potentially compress surrounding blood vessels or tissues, suggesting interference with local blood circulation?", "Does the image show an extensive scalp swelling or associated cranial injuries that could contribute to increased intracranial pressure?", "Are there visual cues suggesting a bleeding or clotting disorder in the newborn, which could alter the absorption rate of a scalp hematoma?", "Is the newborn premature, with a scalp swelling that appears to be resolving slowly, possibly due to immature metabolic or resorptive processes?", "Does the image show a scalp swelling that has persisted for several weeks, raising the risk of calcification due to delayed resolution?", "Is there a scalp mass that appears to restrict movement or flexibility of the overlying scalp, possibly due to its size, tension, or underlying fibrosis?", "Can you identify signs of local inflammation, such as redness or swelling, in the area of a scalp hematoma, which might be due to infection or repeated trauma?", "Is there evidence that the underlying bone may be at risk for infection, such as an infected scalp hematoma or compromised overlying skin?", "Does the newborn appear anemic, possibly as a result of significant blood loss into a large scalp swelling?", "Are there indications of secondary trauma or rebleeding in the area of a scalp hematoma, which could alter the normal healing process?"], "functions": ["Does the image show a region of localized swelling that could indicate disruption of blood circulation beneath the scalp?", "Is there evidence of a collection between the periosteum and skull that might cause local pressure?", "Can you identify an area where inflammation, such as leukocyte infiltration, may be present at a site of injury?", "Does the image suggest delayed healing or impaired tissue repair in the scalp region?", "Is there a visible feature that could be associated with increased risk of anemia or jaundice in a newborn?", "Can you see any signs that might indicate elevated bilirubin levels due to red blood cell breakdown?", "Is there evidence of calcification or abnormal calcium deposition within a scalp lesion?", "Does the image show a region where clot resolution or fibrinolytic activity might be occurring?", "Can you identify an area where phagocytosis or tissue remodeling processes may be active?", "Is there a visible space that could increase the risk of bacterial growth or infection?", "Does the image suggest activation of fibroblasts or deposition of extracellular matrix in a healing scalp lesion?", "Can you see any signs of tenderness or restricted movement in the scalp tissues that could indicate functional impairment?"]}, "no_questions": {"contexual_properties": ["Can you identify a lesion with abnormal vascular patterns, possibly due to angiogenesis or therapy-induced vascular remodeling?", "Can you see a mass with cystic regions, possibly resulting from central necrosis or degeneration?", "Is there a mass with rare calcifications, possibly associated with prior therapy or necrotic changes?"], "properties": ["Does the image show a tumor that lacks expression of estrogen, progesterone, and HER2 receptors?", "Is there a lesion present with absent or very low HER2 expression?", "Can you identify a tumor with high histological grade features?"], "relational": ["Can you observe a high mitotic index or basal-like morphology in the tumor cells?", "Is there evidence of involvement of the mammary, lymphatic, or immune systems in the pathology shown?", "Does the image show a carcinoma affecting breast tissue or the mammary gland epithelium?"], "contexual_behavior": [], "functions": ["Does any tumor in the image appear to lack hormone receptor expression, potentially indicating resistance to endocrine therapies?", "Is there evidence of increased invasiveness or metastatic spread in any of the visible lesions?", "Does the image suggest early recurrence or resistance to targeted therapies in any of the cancerous regions?"]}}, "squamous cell carcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show an abnormality in tissues lined by squamous epithelium, such as the skin or mucous membranes?", "Can you identify a lesion affecting regions like the head and neck, cervix, lungs, esophagus, or skin?", "Is there evidence of a process involving squamous epithelial cells?", "Does the image display changes originating from the epithelial layer of any tissue?", "Can you see a mass or lesion that appears to invade deeper structures such as the dermis, submucosa, muscle, or blood vessels?", "Is there involvement of regional lymph nodes or lymphatic vessels adjacent to an abnormal area?", "Does the abnormality appear to impact systems like the integumentary, respiratory, digestive, or reproductive system?", "Can you identify precursor changes such as actinic keratosis, squamous dysplasia, or carcinoma in situ near the affected area?", "Is there visual evidence of neighboring tissues like connective tissue, muscle, nerves, or blood vessels being involved by a lesion?"], "contexual_behavior": [], "functions": ["Does the image show a region where normal epithelial cells appear to be replaced, potentially compromising barrier integrity?", "Is there evidence of uncontrolled cellular growth or abnormal tissue expansion in the image?", "Can you identify areas where tissue architecture is disrupted, suggesting invasion into surrounding structures?", "Does the image reveal signs of extracellular matrix degradation or breach of the basement membrane?", "Is there visual evidence of new blood vessel formation, possibly indicating neovascularization?", "Can you see regions that might be associated with increased inflammation or immune cell infiltration?", "Does the image suggest the presence of activated fibroblasts or changes in the extracellular matrix composition?", "Are there features that could indicate the presence of secondary tumor sites, such as spread through lymphatic or blood vessels?", "Is there a region where normal tissue regeneration appears impaired or where differentiation of progenitor cells seems inhibited?", "Can you identify areas that might be undergoing chronic inflammation, as indicated by persistent immune cell presence or tissue changes?", "Does the image show architectural changes consistent with matrix metalloproteinase activity or tissue remodeling?", "Is there visual evidence of stromal cell recruitment or modification of the local tissue microenvironment?", "Can you detect features that might reflect resistance to programmed cell death, such as dense clusters of atypical cells?", "Are there any regions that could suggest deregulated cell proliferation, such as loss of normal cell cycle control?"]}, "no_questions": {"contexual_properties": ["Are there areas where cell numbers appear reduced, potentially due to apoptosis, necrosis, or degenerative diseases?", "Can you identify regions with increased cell numbers, suggesting proliferation during development, repair, or in response to growth factors?", "Does the image show evidence of altered calcium levels in cells, such as during contraction, signaling, or in pathological states?"], "properties": ["Is there evidence of cells with a density close to 1.05 grams per cubic centimeter?", "Do you see cells that appear pale eosinophilic or pinkish with hematoxylin and eosin staining?", "Can you identify cells likely to contain contractile proteins such as actin, myosin, tropomyosin, calmodulin, and desmin?"], "relational": ["Does the image contain tissue organization suggesting a subepithelial location for a muscle layer?", "Can you see evidence of connective tissue types such as endomysium or perimysium surrounding muscle fibers?", "Does the image show a tissue layer located just beneath an epithelial lining, separated by a basement membrane?"], "contexual_behavior": ["Does the image show a structure that would increase its contractile activity in response to elevated vasoconstrictor signaling, as seen in hypertension?", "Can you see an object that would change its phenotype from contractile to synthetic after vascular injury?", "Can you see an object that might show impaired contraction due to altered signaling pathways, as is observed in diabetes mellitus?"], "functions": ["Is there a structure that produces powerful contractions during labor or menstruation?", "Can you identify a tissue that contracts to expel urine from the bladder or relaxes to allow bladder filling?", "Can you identify a tissue that generates rhythmic movements to propel contents through hollow organs such as intestines or blood vessels?"]}}, "tumor": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure in the image that appears to originate from epithelial, connective, muscle, or nervous tissue?", "Can you identify an abnormal mass within organs such as the lung, liver, breast, colon, brain, or skin?", "Does the image show an unusual growth in anatomical regions like the head and neck, thorax, abdomen, pelvis, or limbs?", "Is there a visible area composed of densely packed neoplastic or stromal cells?", "Can you see a mass that contains immune cells, endothelial cells, or fibroblasts?", "Is there a structure surrounded by an extracellular matrix or a fibrous capsule?", "Does the image show a mass adjacent to normal tissue?", "Are there blood vessels such as arterioles, capillaries, or newly formed neovasculature supplying a suspicious area?", "Can you identify lymphatic vessels or regional lymph nodes associated with an abnormal structure?", "Is there evidence of a mass infiltrating, compressing, or displacing surrounding tissues?", "Does the image show a structure that could impact the nervous, circulatory, lymphatic, or endocrine systems?", "Is there a region where anatomical barriers like the basement membrane, blood-brain barrier, serosal membranes, or organ capsules appear to be invaded or crossed?"], "contexual_behavior": [], "functions": ["Does the image show a region where cell growth appears uncontrolled or excessive compared to surrounding tissue?", "Can you identify an area that disrupts normal tissue architecture or induces remodeling of the extracellular matrix?", "Is there evidence of a structure interfering with normal cell signaling or blocking differentiation processes?", "Does the image contain a region that might be inhibiting programmed cell death?", "Can you see signs of new blood vessel formation, possibly stimulated by angiogenic factors such as VEGF?", "Is there a visible area that could be evading immune detection or modulating immune cell infiltration?", "Does the image suggest altered metabolic activity, such as increased glycolysis or features consistent with the Warburg effect?", "Can you identify a region invading surrounding tissues, possibly through degradation of the basement membrane or extracellular matrix?", "Is there evidence of cells entering blood or lymphatic vessels, suggesting potential for metastatic spread?", "Does the image show features consistent with resistance to cell death, such as increased cell survival in abnormal regions?", "Can you see modifications in the local microenvironment, such as recruitment of stromal cells or changes in extracellular matrix composition?", "Is there evidence of inflammation, such as accumulation of inflammatory cells or release of cytokines and chemokines?", "Does the image suggest activation of oncogenic signaling pathways or inhibition of tumor suppressor mechanisms?", "Can you identify interactions between abnormal cells and surrounding stromal or immune cells, possibly through direct contact or paracrine signaling?", "Is there evidence of increased genetic instability, such as regions with high mutation rates or impaired DNA repair?", "Does the image suggest systemic effects, such as features associated with cachexia or altered organ function due to released factors?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a mutation with a high predicted pathogenicity score, such as a truncating or frameshift variant?", "Does the sample display a genetic variant present in the heterozygous state?", "Is the molecular weight of the observed protein less than 384 kDa, suggesting a truncating mutation?"], "relational": ["Is there evidence of a structure composed of nucleated cells that could be affected by inherited mutations present in both somatic and germ cells?", "Is there a visible structure that could be part of the reproductive system, endocrine system, or digestive system, which are influenced by certain inherited genetic alterations?", "Does the image include any features suggesting involvement of molecular pathways such as DNA damage response or homologous recombination repair?"], "contexual_behavior": [], "functions": ["Does the image display features consistent with cell cycle dysregulation or checkpoint failure, such as uncontrolled cell division?", "Does the image reveal abnormal regulation of apoptosis, allowing survival of genetically damaged cells?", "Does the image show evidence of impaired DNA repair or increased risk of tumor formation?"]}}, "pus": {"yes_questions": {"contexual_properties": ["Is there a substance in the image that appears thicker, possibly indicating a prolonged infection or dehydration?", "Can you observe a material whose color varies, suggesting differences in the type of infecting organism, presence of blood, or stage of inflammation?", "Is there evidence of a watery exudate that might indicate an early or acute infection?", "Does the image show an accumulation of fluid and cells that could increase in volume with an active inflammatory response?", "Can you identify an area where the volume of a discharge appears reduced, possibly due to resolution, drainage, or immune clearance?", "Is there a visible exudate that might be associated with a foul odor, suggesting anaerobic infection or tissue necrosis?", "Do you see a substance containing visible blood, which could indicate capillary damage or tissue injury at the site?", "Is there a greenish coloration present, possibly due to high neutrophil activity or association with Pseudomonas infection?", "Can you detect a yellowish discharge that might result from the accumulation of dead neutrophils and cellular debris?", "Is there a brownish tint to any exudate, suggesting the presence of degraded blood products or chronic infection?", "Does the image show a collection that could contain a high number of bacteria, indicating active or uncontrolled infection?", "Is there a thin, less viscous fluid present that might be due to dilution by serous fluid or an early stage of infection?", "Can you observe a discharge that may have increased protein content, potentially due to extensive tissue breakdown or high leukocyte turnover?", "Is there evidence of a material with abundant dead cells, reflecting an intense immune response or leukocyte apoptosis?", "Do you see signs that a substance might be more acidic, possibly due to intense bacterial metabolism or anaerobic infection?", "Is there an area where the exudate could be more alkaline, perhaps due to ammonia production by certain bacteria?", "Can you identify changes in the cellular makeup of a discharge, suggesting progression of infection or infiltration by different immune cells?", "Is there a large accumulation of fluid that could indicate abscess formation or impaired drainage?", "Does the image show a thickened material that might result from fluid evaporation at a wound or drainage site?", "Can you observe changes in the consistency of a discharge that might reflect shifts in cellular content, protein concentration, or fluid balance during infection progression?"], "properties": ["Does the image show a substance that appears yellow, green, or white?", "Is there a material with a thick, creamy, or viscous consistency present?", "Can you identify a fluid that might have a foul or unpleasant odor?", "Is there evidence of a substance with high water content, making up most of its volume?", "Does the image contain material that could be rich in neutrophils or macrophages?", "Is there a collection of fluid that might have a protein concentration between 3 and 6 g/dL?", "Can you see a substance that is likely to have low lipid content, less than 1%?", "Is there a fluid accumulation that could have a glucose level lower than that of blood?", "Does the image show a collection whose volume could range from a few milliliters to over a hundred milliliters?", "Is there a substance present that might have a density slightly higher than water, around 1.03 to 1.05 g/mL?", "Can you identify a material that is likely to be at or near body temperature?", "Does the image show a collection that could contain a high concentration of bacteria?", "Is there evidence of a fluid with a very high white blood cell count?", "Can you see a substance that might contain abundant dead cells or cellular debris?", "Is there a material present that could exhibit high viscosity due to its cellular and protein content?", "Does the image suggest the presence of a fluid with elevated levels of enzymes such as lysozyme or proteases?", "Is there a collection that might contain significant amounts of sodium, potassium, or chloride?", "Can you identify a substance that could have high concentrations of inflammatory mediators like cytokines or chemokines?"], "relational": ["Does the image show evidence of acute inflammation in tissues such as the skin, lungs, or mucous membranes?", "Can you identify a region that might contain neutrophils or dead macrophages?", "Is there a visible accumulation that could be associated with bacteria within tissue spaces or wounds?", "Does the image contain a localized collection within an abscess cavity?", "Can you see a structure that might be surrounded by an abscess wall or fibrous capsule?", "Is there an area that appears to be lined by epithelial tissue and contains cellular debris?", "Does the image show a feature that could represent a fistula, sinus tract, or surgical drain facilitating the removal of material from a tissue space?", "Can you identify a collection in subcutaneous tissue, the oral cavity, pleural cavity, or peritoneal cavity?", "Is there a region that suggests the presence of an infected wound resulting from an immune response to bacterial invasion?", "Does the image show a protein-rich fluid containing leukocytes and bacteria within a wound or tissue space?"], "contexual_behavior": ["Does the image show evidence of increased neutrophil response and bacterial lysis, suggesting an acute infection?", "Is there a sign of localized accumulation that could indicate inefficient drainage or a robust immune response?", "Can you identify features that might suggest reduced pus production, such as after antibiotic therapy or surgical debridement?", "Does the image reveal a viscous, dense accumulation that could be associated with chronic inflammation and high protein content?", "Is there visual evidence of wound healing that might be facilitated by drainage or debridement of infectious material?", "Can you see persistent accumulation that could be due to impaired phagocytosis or chronic infection, possibly in an immunocompromised individual?", "Does the image suggest slowed formation or minimal accumulation, as might be seen in immunosuppressed patients with low neutrophil counts?", "Is there a localized, encapsulated collection that could indicate abscess formation with tissue necrosis?", "Can you identify features suggesting the presence of a foreign body, ongoing inflammation, or persistent infection?", "Does the image show changes in the appearance of the accumulation that could correspond to different stages of infection, such as varying cellular or protein content?", "Is there evidence of neutrophilic inflammation that might be triggered by fungal pathogens?", "Does the image lack prominent accumulation, which could suggest a viral infection with minimal neutrophil activity?", "Can you see signs of impaired drainage, such as tissue fibrosis or chronic inflammation obstructing outflow?", "Is there evidence of poor wound healing or chronic wounds that might be associated with diabetes mellitus and increased accumulation?", "Does the image suggest impaired healing or persistent accumulation that could be due to poor circulation or ischemia?", "Can you identify features that might indicate effective immune modulation, such as reduced inflammation and resolution of infection?", "Is there a rapidly accumulating collection in deep tissue, possibly due to poor drainage and extensive tissue necrosis?", "Does the image suggest altered suppurative processes that could be related to autoimmune disease or sterile inflammation?", "Is there evidence of delayed healing or persistent accumulation that might be seen in malnourished individuals with impaired immunity?"], "functions": ["Does the image show evidence of a substance involved in collecting and removing dead cells or debris from an area of infection?", "Can you identify an accumulation that suggests the recruitment of neutrophils or other immune cells at a site of inflammation?", "Is there a visible feature that could indicate the containment or neutralization of invading microorganisms?", "Does the image display material that might be associated with the drainage of infected tissue or removal of pathogens?", "Can you see a localized collection that could be playing a role in isolating infection and facilitating tissue repair?", "Is there an area that appears to be clearing necrotic tissue or promoting the resolution of inflammation?", "Does the image include a structure that could represent a barrier preventing the spread of pathogens, such as an abscess?", "Can you identify a region where cellular debris and dead cells are being eliminated from infected tissues?", "Is there an accumulation that might act as an exudate mediating immune defense and tissue cleanup at a site of infection?", "Does the image show a medium where immune cells like neutrophils or macrophages are aggregating to target pathogens?"]}, "no_questions": {"contexual_properties": ["Can you identify a vessel that appears compressed by an external mass, tumor, or edema?", "Does the image show a vessel segment with increased diameter, as seen in aneurysm or dilation?", "Is there a region in the image where a vessel appears narrowed, suggesting possible stenosis or atherosclerosis?"], "properties": ["Is there a lumen whose size appears within the normal range for its anatomical structure?", "Is there a passage whose diameter falls within the expected physiological range for its type?", "Does the image contain a structure with a pinkish or pale color, indicating healthy tissue?"], "relational": ["Does the image display a segment of a vessel or duct that appears open and unobstructed?", "Does the image show a vessel or duct that enables fluid flow, nutrient transport, or waste removal?", "Does the image show a structure adjacent to surrounding tissues or neighboring vessels with a visible open lumen?"], "contexual_behavior": ["Can you see a vessel with decreased openness that may be due to chronic inflammation, ongoing tissue damage, or fibrosis?", "Is there a vessel segment where recovery has failed after trauma or injury, possibly due to persistent damage or inadequate healing?", "Is there a region where a stent appears to be holding a vessel open, resulting in increased patency?"], "functions": ["Can you see features that indicate the prevention of vascular obstruction, reducing the risk of ischemia or infarction?", "Is there evidence of vessel integrity being maintained, with no signs of collapse or blockage?", "Is there visual evidence suggesting successful restoration or preservation of vessel openness, as might be assessed after surgery?"]}}}
[ { "answer": "no", "extracted_concepts": [ "white chalky deposits" ], "question": "are the areas of white chalky deposits illustrated schematically?" } ]	["white chalky deposits"]	{"white chalky deposits": {"yes_questions": {"contexual_properties": ["Does the image show any areas that appear larger due to ongoing accumulation of calcium or urate salts?", "Are there multiple regions that could indicate persistent metabolic or inflammatory processes such as chronic gout or soft tissue calcification?", "Can you identify any regions where a change in color suggests secondary infection, hemorrhage, or chemical alteration?", "Is there evidence of hardening in certain areas that might result from progressive mineralization or crystal growth?", "Do any regions appear softened, possibly due to local enzymatic activity, inflammation, or medical treatment?", "Are there new locations in the image where abnormal material has appeared, suggesting disease progression or systemic metabolic imbalance?", "Can you observe a decrease in the amount of abnormal material, potentially indicating effective therapy or disease resolution?", "Are there areas that look more prominent because of thinning overlying tissues, increased inflammation, or growth of the abnormal material?", "Is there visual evidence of dissolution, such as reduction in size or disappearance of abnormal material, possibly due to chelation therapy or restored metabolic balance?", "Do you see changes in the appearance of deposits that could be attributed to shifts in calcium or uric acid levels?", "Are there signs of local inflammation or tissue injury associated with the abnormal material, suggesting immune activation or crystal-induced inflammation?", "Can you identify structures that would be visible on radiographic imaging due to sufficient size or density?", "Are there regions with irregular borders, possibly resulting from partial resorption, fragmentation, or infiltration by inflammatory cells?", "Do any areas appear denser, consistent with mineral accumulation or maturation of the abnormal material?", "Are there regions where the abnormal material is less distinct, perhaps due to partial dissolution, surrounding edema, or soft tissue reaction?"], "properties": ["Does the image show any structures that appear white in color?", "Can you identify any areas with a chalky, brittle, or powdery texture?", "Is there evidence of deposits that could be composed of minerals such as calcium phosphate or calcium carbonate?", "Are there any granular, irregular, or nodular formations visible?", "Can you see any objects that might have a crystalline or microcrystalline appearance, such as hydroxyapatite or calcite?", "Is there a structure whose density could be consistent with that of calcium salts, around 2.7 g/cm\u00b3?", "Are there deposits that might have a hardness of approximately 3\u20135 on the Mohs scale?", "Can you identify any formations that are likely to be slightly soluble or insoluble in water?", "Is there a visible deposit that could have a high calcium content, possibly exceeding 30% by weight?", "Are there any objects that might contain significant phosphorus, as would be expected if calcium phosphate is present?", "Can you see any deposits that are likely to have low to moderate magnesium content?", "Are there structures whose size ranges from micrometers to several centimeters?", "Is there evidence of masses that could weigh from milligrams to several grams?", "Do any of the visible deposits have a neutral to slightly alkaline appearance, as might be inferred from their context?"], "relational": ["Does the image show any abnormal material within joints, kidneys, skin, or heart valves?", "Can you identify any changes in tendons, subcutaneous tissue, or synovial membranes that might indicate an underlying pathological process?", "Is there evidence of involvement of the musculoskeletal, renal, integumentary, or cardiovascular systems by abnormal deposits?", "Are there visible alterations in periarticular areas, fingers, elbows, or ears that could suggest a localized pathological process?", "Can you see any clusters of cells such as macrophages, fibroblasts, lymphocytes, or giant cells near abnormal deposits?", "Is there a region where abnormal material appears to be associated with collagenous structures or the extracellular matrix?", "Are there any blood vessels, nerves, or muscle fibers adjacent to abnormal deposits in the image?", "Does the image show structural changes in organs like the kidneys, heart, skin, or joints that could be due to abnormal deposits?", "Can you identify firm nodules, areas of discoloration, or calcified masses that distinguish certain regions from the surrounding tissue?", "Is there evidence of larger pathological structures such as tophi, calcified plaques, or dystrophic calcifications that might contain abnormal deposits?"], "contexual_behavior": ["Does the image show evidence of tissue injury where abnormal mineral accumulation is present?", "Is there a region in the image that suggests dystrophic calcification in damaged or necrotic tissues?", "Can you identify any deposits that might be more prominent in the context of chronic kidney disease?", "Is there visual evidence of abnormal accumulation that could be linked to impaired phosphate excretion or secondary hyperparathyroidism?", "Does the image contain deposits that may have formed rapidly in response to elevated calcium levels?", "Can you see any abnormal mineralization in otherwise healthy tissues that could suggest metastatic calcification?", "Is there a reduction in abnormal deposits that might indicate correction of a metabolic imbalance or normalization of calcium levels?", "Does the image show any features that could impair joint function, such as accumulation of monosodium urate crystals?", "Is there evidence of joint inflammation or reduced mobility due to crystal deposition?", "Can you identify any changes that might suggest a response to medical intervention, such as therapy-induced reduction of abnormal deposits?", "Are there areas of soft tissue with increased abnormal mineralization that could be associated with metabolic disorders like hyperparathyroidism or pseudogout?", "Does the image show impaired wound healing or chronic inflammation in the skin due to abnormal mineral accumulation?", "Is there evidence of organ dysfunction or calcification that could be related to systemic diseases such as systemic sclerosis or chronic renal failure?", "Can you see more prominent abnormal deposits in regions that appear to have experienced trauma or tissue necrosis?", "Is there visual evidence of vascular dysfunction, such as stiffened vessel walls, that could be due to calcific vasculopathy?", "Are there fewer abnormal deposits in areas where dietary modification or metabolic control may have reduced serum calcium or uric acid levels?", "Does the image suggest increased abnormal mineralization in association with autoimmune conditions or connective tissue diseases?", "Is there evidence that abnormal deposits are interfering with normal enzymatic activity or disrupting the local biochemical environment in tissues?"], "functions": ["Does the image show evidence of mineral precipitation within tissues?", "Can you identify areas that might indicate dystrophic or metastatic calcification?", "Is there a region that could be causing mechanical obstruction or reduced elasticity in the tissue?", "Does the image reveal signs of cellular damage potentially linked to abnormal mineral accumulation?", "Are there features suggesting chronic inflammation or ongoing pathology in the tissue?", "Can you see any evidence of immune cell recruitment or local tissue irritation?", "Does the image display patterns consistent with macrophage activation, fibrosis, or granuloma formation?", "Is there a structure that appears to be causing obstruction or loss of compliance in an organ?", "Can you identify areas where functional decline of tissue might be occurring?", "Are there visual cues of cellular stress or impaired nutrient exchange in the affected region?", "Does the image suggest mitochondrial dysfunction or altered cellular metabolism in certain areas?", "Can you see signs of phagocytosis or an inflammatory response in the tissue?", "Is there evidence of calcium salt accumulation or matrix mineralization leading to tissue hardening?", "Does the image show features that could contribute to delayed tissue repair or persistent tissue damage?"]}, "no_questions": {"contexual_properties": ["Can you observe abnormal methylation patterns that might be linked to tumorigenesis or epigenetic dysregulation?", "Does the image suggest gene amplification in malignancies such as ovarian or lung cancer, possibly indicating increased oncogenic signaling?", "Does the image reveal alternative splicing events during embryonic development, tissue-specific expression, or within cancer cells?"], "properties": ["Is there a visual cue suggesting moderate gene expression in immune or epithelial cells?", "Does the image show any indication of gene variants such as E545K or H1047R, which are commonly associated with oncogenic processes?", "Is there a protein product depicted that functions as a catalytic subunit in a lipid kinase complex?"], "relational": ["Can you identify regulatory elements such as promoters, enhancers, or CpG islands?", "Does the image include liver, brain, muscle, or blood tissue where this gene might be expressed?", "Is there a structure that could produce proteins like p110\u03b1, p110\u03b2, p85\u03b1, or p110\u03b4?"], "contexual_behavior": ["Does the image suggest enhanced function during immune cell activation, such as increased lymphocyte proliferation?", "Is there evidence of reduced survival signaling under hypoxic conditions, suggesting impaired pathway activation?", "Is there a visual cue indicating modulated activity in response to oxidative stress, possibly affecting cell survival or repair?"], "functions": ["Does the image suggest integration of growth factor signals leading to cellular differentiation or determination of cell fate?", "Does the image show translocation of glucose transporters to the cell membrane, indicating active insulin signaling?", "Is there visual evidence of enhanced cell survival, possibly due to anti-apoptotic signaling or AKT phosphorylation?"]}}}
[ { "answer": "sagittal section of atlas vertebra and occipital bone foramen magnum stenosis case 31", "extracted_concepts": [ "occipital bone", "stenosis", "atlas vertebra", "sagittal section", "foramen magnum" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "foramen magnum stenosis", "occipital bone", "sagittal section", "atlas vertebra" ], "question": "does this image show sagittal section of atlas vertebra and occipital bone foramen magnum stenosis case 31?" }, { "answer": "no", "extracted_concepts": [ "occipital bone", "atlas vertebra", "sagittal section", "foramen magnum stenosis", "foramen magnum" ], "question": "does source show sagittal section of atlas vertebra and occipital bone foramen magnum stenosis case 31?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "intestine" ], "question": "is intestine present?" }, { "answer": "rheumatoid arthritis", "extracted_concepts": [ "rheumatoid arthritis" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "rheumatoid arthritis" ], "question": "is rheumatoid arthritis present?" }, { "answer": "no", "extracted_concepts": [ "chromophobe adenoma" ], "question": "is chromophobe adenoma present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "rheumatoid arthritis", "extracted_concepts": [ "rheumatoid arthritis" ], "question": "what is present?" } ]	["occipital bone", "intestine", "atlas vertebra", "stenosis", "bone", "chromophobe adenoma", "sagittal section", "rheumatoid arthritis", "foramen magnum stenosis", "foramen magnum", "calvarium"]	{"occipital bone": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a component of the cranium that is positioned near the posterior cranial fossa?", "Can you identify a structure that articulates with the atlas (C1 vertebra)?", "Is there a bone that connects to the parietal and temporal regions via cranial sutures?", "Does the image contain a structure featuring a large opening for the passage of the spinal cord?", "Can you see any foramina such as the hypoglossal canal or condylar canal in the depicted bone?", "Is there a visible external occipital protuberance or nuchal lines present in the image?", "Can you identify occipital condyles that would articulate with the first cervical vertebra?", "Does the image show a region where the trapezius or semispinalis capitis muscles might attach?", "Is there a structure through which the hypoglossal nerve (cranial nerve XII) could pass?", "Can you see any anatomical features associated with the passage of the vertebral arteries or occipital vein?", "Is there a bone adjacent to the occipital lobe or cerebellum of the brain?"], "contexual_behavior": ["Does the image show a cranial structure whose ability to protect the brain may be compromised following trauma or fracture?", "Is there evidence of a bone in the posterior skull region where reduced mineral density could indicate compromised structural support, as seen in osteoporosis?", "Can you identify a region of the skull where a fracture might alter cranial stability due to loss of bone continuity?", "Does the image reveal any signs of bone erosion or atrophy at muscle attachment sites that could suggest degenerative disease?", "Is there a structure contributing to the foramen magnum whose integrity might be affected by congenital malformations such as basilar invagination?", "Can you observe features of a cranial bone where increased porosity or decreased mass, possibly due to aging, could reduce its ability to absorb impact forces?", "Does the image show any signs of weakened bone structure in the posterior skull that could be associated with osteomyelitis or other bone infections?", "Is there evidence of altered articulation with the cervical spine that might suggest surgical intervention affecting head movement support?", "Can you see any abnormalities in the enclosure of the posterior cranial fossa that might indicate developmental disorders affecting bone formation?", "Does the image display a cranial bone whose resistance to pressure appears reduced, possibly due to metabolic bone diseases like Paget's disease or rickets?"], "functions": ["Does the image show a structure that protects the back part of the brain?", "Is there a bone forming the posterior and inferior walls of the cranial cavity?", "Can you identify a region that shields the occipital lobes from injury?", "Does the image contain a structure that supports the head by connecting with the first cervical vertebra?", "Is there evidence of an articulation that allows for nodding movements of the head?", "Can you see an area providing attachment points for neck muscles such as the trapezius?", "Is there a visible feature that serves as an anchor for nuchal muscles?", "Does the image include a bone forming the posterior base of the cranial cavity?", "Can you identify an opening at the base of the skull that allows the spinal cord to pass through?", "Is there a structure enclosing the foramen magnum?", "Does the image show a bone that articulates with the parietal, temporal, and sphenoid bones to maintain cranial stability?", "Can you see a region that contributes to head movement and stability by serving as an attachment site for ligaments?"]}, "no_questions": {"contexual_properties": ["Does the image show loss of the normal vascular pattern, possibly due to chronic inflammation or dysplasia?", "Is there evidence of exudates that could suggest infectious or pseudomembranous colitis?", "Does the image display pale mucosa, which could indicate anemia or chronic blood loss?"], "properties": ["Can you assess whether the contrast ratio in the image is within the typical range of 300:1 to 1000:1?", "Does the depth of field in the image seem to be between 3 mm and 50 mm?", "Can you determine if the image resolution falls within the range of VGA to Full HD?"], "relational": ["Is the visualized area part of a system like the digestive, respiratory, urinary, or reproductive system?", "Can you see tissues such as epithelial, connective, or lymphoid tissue in the image?", "Are there identifiable landmarks such as the pylorus, vocal cords, ileocecal valve, or ureteral orifice present?"], "contexual_behavior": [], "functions": ["Does the image enable accurate localization of suspicious tissue suitable for targeted sampling or biopsy?", "Is there visual information that could support immediate clinical assessment or decision-making regarding internal organs?", "Can you identify any abnormalities such as lesions, tumors, or signs of inflammation in the internal tissues shown?"]}}, "intestine": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify regions that could correspond to both a small and a large tubular organ within the abdomen?", "Is there a structure that appears directly connected to the stomach or the cecum?", "Does the image display any features that might indicate a connection to the anus?", "Can you see evidence of blood vessels such as branches of the superior or inferior mesenteric arteries supplying a tubular organ?", "Is there a structure that could be innervated by the enteric nervous system or vagus nerve?", "Does the image show a wall with multiple layers, such as mucosa, submucosa, muscularis externa, and serosa?", "Can you identify lymphatic structures like Peyer's patches or mesenteric lymph nodes associated with a tubular organ?", "Is there a visible feature that could represent the ileocecal valve separating two regions of a tubular structure?", "Does the image show an organ suspended within the abdominal cavity by a mesentery?", "Can you see an inner lining that might be composed of simple columnar epithelium with goblet cells?", "Is there a structure adjacent to the liver, pancreas, or spleen?", "Does the image reveal connections to ducts such as the bile duct or pancreatic duct, or to the anal canal?"], "contexual_behavior": [], "functions": ["Does the image show a structure involved in nutrient absorption and water reabsorption?", "Can you identify a region lined with villi or microvilli to increase surface area for uptake?", "Is there evidence of specialized epithelial cells that facilitate absorption of nutrients?", "Does the image contain a structure responsible for enzymatic breakdown of macromolecules?", "Can you see an area where water is reclaimed to maintain fluid balance, such as the colon?", "Is there a region where undigested material is compacted to form waste for excretion?", "Does the image show tissue associated with gut-associated lymphoid structures or immune cell production?", "Can you identify smooth muscle layers that might be involved in coordinated contractions for motility?", "Is there a visible feature suggesting the presence of beneficial microbes or maintenance of gut flora balance?", "Does the image show any structures that could be involved in absorbing or secreting ions like sodium or potassium?", "Can you see evidence of digestive enzymes or microbial fermentation enabling nutrient release?", "Is there an area that might contain enteroendocrine cells responsible for gut hormone secretion?", "Does the image show a physical barrier or tissue involved in immune defense or antimicrobial secretion?", "Can you identify features that suggest absorption of fat-soluble vitamins or vitamin B12?", "Is there evidence of a process or structure involved in recycling bile salts for fat digestion?", "Does the image show any indication of neuroregulation, such as connections to the enteric nervous system or vagus nerve?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there visual indication of high proliferation rates among the cells?", "Can you see evidence of coarse or vesicular chromatin patterns in any of the cells?", "Can you identify cells that display a high nuclear-to-cytoplasmic ratio?"], "relational": ["Does the image contain cells or regions that express basal cytokeratins?", "Is there evidence of structures associated with the basement membrane in the image?", "Can you see an epithelial layer lacking hormone receptor expression?"], "contexual_behavior": [], "functions": ["Can you observe activity of signaling pathways such as Notch, Wnt, or EGFR that are important for cell fate determination?", "Is there evidence of cell-cell adhesion, extracellular matrix interaction, or paracrine signaling coordinating tissue function?", "Can you identify cells that express basal cytokeratins within the epithelial layer?"]}}, "atlas vertebra": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a ring-shaped, oval bone structure visible in the image?", "Can you identify a bone that lacks a vertebral body?", "Does the image show a structure with approximately three foramina, including two transverse openings?", "Is there a bone present with a vertebral foramen diameter of about 2.5 cm?", "Can you see a structure with transverse processes measuring around 2 cm in length?", "Is there a bone with minimal curvature, maintaining a nearly flat ring appearance?", "Does the image contain a structure with a width of about 4 cm and a height of approximately 2.5 cm?", "Can you identify a bone whose thickness ranges from 0.5 to 1 cm?", "Is there a structure with a smooth surface and slightly rough areas where muscles might attach?", "Does the image show a bone with an off-white to pale yellow coloration?", "Is there a structure composed of both cortical and cancellous bone tissue?", "Can you see a bone with a typical volume of 8 to 10 cubic centimeters?", "Is there a structure with a bone density between 1.2 and 1.5 grams per cubic centimeter?", "Does the image include a bone with a porosity of around 5 to 15 percent?", "Can you identify a structure whose mineral content is predominantly hydroxyapatite, making up about 60 to 70 percent of its dry weight?", "Is there a bone present with a water content of approximately 10 to 20 percent by weight?", "Does the image show a structure with cartilage on its articular surfaces that is about 1 to 2 millimeters thick?", "Can you see a bone containing cells such as osteocytes, osteoblasts, and osteoclasts?", "Is there a structure with an average weight of about 20 grams?"], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Is there a bone in the cervical region of the spine visible in the image?", "Can you identify a vertebra that articulates with both the occipital bone and another cervical vertebra?", "Does the image contain a joint that enables head rotation, such as a pivot joint between two cervical vertebrae?", "Is there evidence of the atlanto-occipital or atlanto-axial joint present in the image?", "Can you see ligaments such as the transverse ligament, alar ligaments, or anterior longitudinal ligament attached to a cervical vertebra?", "Is there a vertebra in the image that lacks a vertebral body and spinous process but has large lateral masses?", "Does the image show passageways for the spinal cord, vertebral arteries, or spinal nerves near the upper cervical spine?", "Can you identify attachment sites for muscles like the rectus capitis anterior, rectus capitis lateralis, or obliquus capitis superior on a cervical vertebra?", "Is there a structure associated with the first cervical spinal nerve or the suboccipital nerve visible in the image?"], "contexual_behavior": ["Does the image show a cervical structure whose support for head movement appears compromised, possibly due to fracture or ligament injury?", "Is there evidence of decreased stabilization of the upper cervical spine, as might be seen after trauma or in inflammatory disease?", "Can you identify a vertebral element that fails to protect the spinal cord effectively in the presence of dislocation or severe fracture?", "Does the image suggest impaired head rotation, such as might occur in atlantoaxial subluxation or arthritis?", "Is there a sign that cranial weight distribution is altered, as could happen after a Jefferson fracture or compressive injury?", "Can you see excessive movement or instability in the upper cervical region, possibly due to torn or absent ligaments?", "Does the image reveal decreased neck flexibility, as might be associated with osteoarthritis or spondylosis?", "Is there evidence that vertebral artery flow could be compromised by subluxation, fracture, or vascular compression in the cervical region?", "Can you observe weakened support for the occipital condyles, such as might occur in rheumatoid arthritis with ligamentous erosion?", "Does the image show diminished ability to absorb mechanical stress in the upper cervical vertebrae, possibly due to fracture or bone loss?", "Is there restriction of head nodding movement, as might be seen in cases of meningitis or local synovitis?", "Can you detect altered cervical alignment, such as might result from atlas hypoplasia or congenital fusion anomalies?", "Does the image suggest decreased protection for neural structures in the cervical spine, as could occur with osteoporosis and increased fracture risk?", "Is there visible limitation of movement in the upper cervical region due to muscular spasm, such as in torticollis or cervical muscle strain?", "Can you see changes in head tilt facilitation, possibly related to ligamentous laxity from connective tissue disorders or trauma?"], "functions": ["Is there a structure in the image that supports the skull and facilitates head movement?", "Can you identify an anatomical feature that forms a joint with the occipital bone to allow the head to move up and down?", "Does the image show a structure that contributes to neck mobility and cervical flexibility?", "Is there an object that, together with another vertebra, enables rotation of the head through a specialized joint?", "Can you see a structure that articulates with the occipital condyles to enable nodding motions?", "Is there a bony ring encircling and protecting the upper portion of the spinal cord as it transitions from the brain to the vertebral column?", "Does the image contain a structure that transmits forces between the skull and cervical spine by distributing loads?", "Can you identify an anatomical feature that helps maintain posture by supporting the alignment of the head on the cervical spine?", "Is there a structure that assists in stabilizing the head through strong ligamentous and bony connections with the skull and another vertebra?"]}, "no_questions": {"contexual_properties": ["Does the image show a case of conjoined twins with a shared head and thorax?", "Can you identify a condition where two individuals are fused at the upper body and head regions?", "Is there evidence of two faces oriented in opposite directions on a single head?"], "properties": ["Does the image depict a fusion of two bodies with a single head exhibiting two faces?", "Does the image show a case where two individuals are conjoined at both the head and the chest regions?", "Is there evidence of duplicated cranial or facial structures within a single fused upper body?"], "relational": ["Can you identify a structure affecting the respiratory, cardiovascular, or digestive systems due to fusion of the upper body?", "Does the image show two faces that appear duplicated on a single upper body?", "Is there a visible joining of the skull base, cervical vertebrae, or thoracic spine?"], "contexual_behavior": ["Is there evidence of anatomical fusion in the thoracic region that could indicate shared heart or major vessels?", "Does the image suggest the presence of shared vascular structures that might alter circulatory dynamics during physical activity?", "Can you identify features suggesting that both heads might rely on a single or partially shared respiratory system?"], "functions": ["Does the image reveal the presence of conjoined hearts or major vessels that might affect circulatory system regulation?", "Does the image suggest altered body surface area or shared metabolic regions that might disrupt thermoregulation?", "Do you observe duplicated or fused neural pathways or musculoskeletal structures that could impair coordination of motor activities?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Is there a staining pattern that appears borderline or equivocal, potentially caused by technical artifacts or pre-analytical tissue changes?", "Can you identify evidence of tumor progression that might alter the receptor status from undetectable to detectable?", "Does the image suggest changes in assay sensitivity that might impact the detection of certain proteins in tumor cells?"], "properties": ["Can you observe poorly differentiated, high-grade tumor cell morphology in the sample?", "Does the tumor exhibit features consistent with a high histological grade, such as grade 2 or 3?", "Can you identify frequent areas of tumor necrosis within the tissue?"], "relational": ["Does the image show a tumor in the breast or a metastatic site that lacks both estrogen receptor and HER2 expression?", "Is there a structure in the image, possibly from a tumor biopsy, where both ER and HER2 biomarkers are absent?", "Can you identify a breast tumor where the nuclei do not show ER staining and the cell membranes do not show HER2 staining?"], "contexual_behavior": ["Can you see features of a neoplasm that may evade apoptosis through non-receptor-mediated survival mechanisms?", "Can you identify a tumor with features suggestive of high proliferation and aggressive growth patterns?", "Does the tumor appear to have a growth rate during pregnancy that is not driven by hormonal changes?"], "functions": ["Does the tumor appear to have characteristics associated with early relapse or a greater likelihood of metastasis to visceral organs or the central nervous system?", "Does the image suggest a tumor with an aggressive phenotype and a higher risk of recurrence?", "Is there evidence of upregulated alternative signaling pathways, such as increased EGFR or basal marker expression?"]}}, "chromophobe adenoma": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a lesion measuring between 1 and 3 centimeters in diameter visible in the image?", "Can you identify a mass that appears to weigh less than 10 grams based on its size and context?", "Does the image show a round or oval structure?", "Is there a mass with a pale tan or grayish-white coloration?", "Can you see a tumor composed predominantly of cells with abundant pale cytoplasm and sparse supporting stroma?", "Does the lesion exhibit a low mitotic index, with rare mitotic figures present?", "Is there evidence of cells with a low to moderate nuclear-cytoplasmic ratio within the mass?", "Can you observe cells with abundant, pale, and finely granular cytoplasm in the structure?", "Does the image show cells with a fine and evenly distributed chromatin pattern?", "Is there a mass that appears to have high water content, as suggested by the cytoplasmic features?", "Can you identify a tumor with low lipid content based on its histological appearance?", "Does the structure display low hormone expression and positive staining for cytokeratins?", "Is there a tumor with moderate cell density compared to other pituitary neoplasms?", "Does the lesion appear to have a slow growth rate based on its characteristics?", "Can you see evidence of low or absent hormone content, indicating a non-functioning tumor?", "Is there a mass with low to moderate vascularity visible in the image?", "Does the structure show rare or infrequent calcification?", "Can you identify a lesion with a soft and rubbery texture?", "Is there minimal to mild fibrosis present in the tumor?", "Does the mass exhibit a very low rate of necrosis?"], "relational": ["Does the image show a lesion affecting the endocrine system?", "Is there an abnormality associated with the pituitary gland?", "Can you identify a mass located in the sellar region of the brain?", "Is there evidence of a structure adjacent to the optic chiasm or cavernous sinus?", "Does the image reveal a lesion near the sphenoid sinus?", "Is there a mass surrounded by dura mater or the pituitary capsule?", "Can you see an abnormality involving the anterior lobe (pars distalis) of the pituitary gland?", "Is there a lesion supplied by the superior or inferior hypophyseal arteries?", "Does the image show a mass in proximity to the optic nerve, oculomotor nerve, or abducens nerve?", "Is there evidence of expansion or involvement of the sella turcica?", "Can you identify a structure that appears to compress the optic chiasm or cavernous sinus?", "Does the image show a lesion adjacent to brain parenchyma?"], "contexual_behavior": ["Is there evidence of a mass within the sella turcica that could be compressing or destroying healthy pituitary tissue?", "Does the image show a lesion that might be associated with reduced secretion of pituitary hormones?", "Can you identify a structure that could cause pituitary dysfunction by exerting pressure on surrounding tissue?", "Is there a mass that appears non-secretory, even under stress conditions?", "Does the image suggest the presence of a tumor that might show reduced metabolic activity in a hypoxic environment?", "Can you see a lesion whose hormone secretion patterns could be altered by medications affecting pituitary or hypothalamic signaling?", "Is there a structure that could disrupt endocrine feedback loops by failing to respond to regulatory hormones?", "Does the image show a mass that might decrease in size or growth rate following radiotherapy?", "Is there evidence of a lesion that could interfere with normal hormonal rhythms, especially during sleep deprivation?", "Can you identify a mass that increases pressure on adjacent pituitary tissue as it enlarges?", "Is there a structure that might show reduced responsiveness to hypothalamic signals due to receptor deficiency?", "Does the image suggest a lesion whose secretory behavior could change during pregnancy?", "Can you see a mass that might fail to suppress hormone secretion in response to negative feedback mechanisms?", "Is there evidence of increased proliferative activity in response to growth factors within a pituitary mass?", "Does the image show a lesion that could lead to decreased hormone output after surgical removal or damage to hormone-producing tissue?", "Can you identify a structure that might impair water balance regulation, particularly if antidiuretic hormone production is affected?"], "functions": ["Does the image show a pituitary tumor composed of cells that do not appear to be actively secreting hormones?", "Is there evidence of a mass that could cause reduced or absent secretion of pituitary hormones, potentially leading to endocrine dysfunction?", "Can you identify a lesion that might compress normal pituitary tissue and impair hormone production?", "Does the image contain a structure that could disrupt the regulation of peripheral endocrine glands by decreasing trophic hormone output?", "Is there a mass that could be responsible for metabolic dysregulation due to decreased levels of hormones such as ACTH, TSH, or GH?", "Can you see a lesion that might interfere with the normal feedback mechanisms between the hypothalamus, pituitary, and target glands?", "Is there a structure that could explain growth impairment or developmental delay due to reduced growth hormone secretion?", "Does the image show a mass that could be responsible for hormonal imbalances or deficiencies in one or more pituitary hormones?", "Can you identify a lesion that might impair the body's stress response by reducing ACTH and consequently cortisol levels?", "Is there evidence of a mass that could interfere with reproductive hormone regulation by lowering LH and FSH secretion, potentially resulting in hypogonadism?"]}, "no_questions": {"contexual_properties": ["Do you notice any abnormal surface appearances, such as ulceration, nodularity, or exudate formation?", "Does any area show changes in measurable properties that could be related to inflammation, infection, or malignancy?", "Is there a swollen region that could be due to acute inflammation, infection, or trauma?"], "properties": ["Does the image show something whose chemical composition is unknown in biomedical contexts?", "Can you see a region whose protein content is not defined in biomedical sources?", "Does the image include an object whose temperature is not defined in biomedical sources?"], "relational": ["Does the image show an organ that is part of the urinary system and located in the abdominal cavity?", "Can you identify a structure adjacent to the spleen, pancreas, or left adrenal gland?", "Can you identify a structure containing renal pyramids, renal columns, or calyces?"], "contexual_behavior": ["Can you identify a structure that appears to increase its metabolic contribution during fasting or altered energy states?", "Does the image show an area that appears more active or involved in tissue repair and regeneration during recovery from injury?", "Is there a structure that appears to shift its activity during acute infection, possibly participating in immune defense or metabolic changes?"], "functions": ["Is there a structure that supports metabolic, regulatory, or protective functions?", "Can you identify something that influences biochemical reactions or manages energy within the body?", "Is there an object present that supports or modulates key bodily operations?"]}}, "sagittal section": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display anatomical structures such as the brain, spinal cord, or nasal cavity in a way that suggests a view parallel to the median plane?", "Can you identify regions of the body like the head, neck, thorax, abdomen, pelvis, or limbs as if they have been sectioned to reveal internal features along a left-right axis?", "Is there evidence that the view is perpendicular to coronal and transverse planes, showing structures as they would appear in a sagittal orientation?", "Does the image provide a perspective that allows examination of organs such as the heart, uterus, or spinal cord in profile?", "Are tissues such as bone, muscle, nervous tissue, mucosa, or glandular tissue visible in a way that suggests a side-to-side division?", "Can you see features belonging to the nervous, musculoskeletal, digestive, or reproductive systems as they would be revealed by a section dividing the body into left and right portions?", "Are anatomical landmarks like the corpus callosum, pituitary gland, nasal septum, or vertebral bodies visible from a side view?", "Does the image show structures separated into left and right sides rather than anterior and posterior portions?", "Is the corpus callosum, cerebellum, brainstem, thalamus, or hypothalamus visible as they would appear in a longitudinal section through the brain?"], "contexual_behavior": [], "functions": ["Does the image provide a side view that allows detailed visualization of structures along the left-right axis?", "Can you observe anatomical structures divided into left and right portions, enabling assessment of their spatial relationships and depth?", "Is there evidence in the image that allows evaluation of organ alignment or detection of deviations from the midline?", "Does the image display the brain or spinal cord in profile, facilitating the identification of lesions, malformations, or compression?", "Can you assess tissue integrity, detect masses, or visualize anatomical landmarks based on the sectional view presented?", "Does the image offer precise anatomical detail that could assist in planning surgical incisions or avoiding critical structures?", "Is it possible to evaluate joint articulation and range of motion in the anterior-posterior direction using the view provided?", "Can you analyze the alignment and interaction of bones, muscles, and connective tissues to understand musculoskeletal function in this plane?"]}, "no_questions": {"contexual_properties": ["Can you identify changes in glandular patterns, such as loss or alteration, which may be associated with tumor progression or therapy response?", "Are there hemorrhagic regions within the mass, possibly due to rupture of fragile vessels or rapid growth?", "Does the image show calcified regions within the mass, possibly due to dystrophic mineralization in necrotic areas?"], "properties": ["Can you identify tumor cells that measure between 15 and 25 micrometers in diameter?", "Does the architectural pattern predominantly show acinar or tubular arrangements with orderly gland formation?", "Is there evidence of a moderate nuclear-to-cytoplasmic ratio in the cells present?"], "relational": ["Does the image display cells with features of malignant glandular epithelial cells?", "Is there evidence of encapsulation around a suspicious mass?", "Is there a structure surrounded by a basement membrane or adjacent to normal parenchyma?"], "contexual_behavior": ["Can you identify a region with upregulated growth factor signaling, such as increased receptor expression?", "Is there evidence of a structure that increases its proliferative activity under low-oxygen conditions?", "Does the image display features suggestive of increased invasive behavior in the context of chronic inflammation?"], "functions": ["Does the image reveal features suggestive of increased cell proliferation or loss of growth control?", "Does the image show a region with abnormal gland-like structures formed by uncontrolled epithelial cell growth?", "Can you identify regions where metabolic changes, such as increased glycolysis, might be inferred from cellular morphology?"]}}, "rheumatoid arthritis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of joint swelling affecting between 4 and 10 joints?", "Can you identify signs of tenderness in 6 to 12 joints?", "Is there visible morning stiffness that appears to last longer than 60 minutes?", "Does the image display subcutaneous nodules in approximately 20 to 30% of the individuals shown?", "Are there radiographic features indicating mild to moderate joint erosions, with scores that might fall between 10 and 50 on the Sharp/van der Heijde scale?", "Can you observe any extra-articular manifestations present in about 40% of the depicted cases?", "Is there visual evidence suggesting a disease duration spanning 10 to 20 years?", "Does the image suggest the presence of anemia, with hemoglobin levels likely between 10 and 12 g/dL?", "Are there indications of elevated synovial fluid white blood cell counts, possibly ranging from 5,000 to 50,000 cells/\u03bcL?", "Can you infer that the average age of onset for the condition in the individuals shown is between 30 and 60 years?", "Is there evidence suggesting moderate to high disease activity, with a disease activity score (DAS28) likely between 3.2 and 5.1?"], "relational": ["Does the image show evidence of a condition affecting both the musculoskeletal and immune systems?", "Can you identify abnormalities in joints such as those of the hands, wrists, feet, or knees?", "Is there visible damage to structures like the synovial membrane, cartilage, ligaments, or bone within a joint?", "Does the image display chronic inflammation of the tissue lining a joint cavity?", "Are there signs of connective tissue involvement, such as changes in the synovium, tendons, or ligaments?", "Can you see structural alterations in bones such as the phalanges, metacarpals, or carpal bones?", "Is there evidence of joint deformity or bone erosions in the regions commonly affected by autoimmune processes?", "Does the image reveal features like synovial hyperplasia or cartilage erosion within a joint?", "Are there indications of an autoimmune process targeting joint tissues?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Is there a tumor with infiltrative borders, suggesting invasive characteristics and tissue degradation?", "Is there a mass that appears to have lost hormone receptor positivity, potentially due to progression, dedifferentiation, or therapy resistance?", "Does the image reveal a tumor with features suggesting increased estrogen receptor activity, such as in early tumorigenesis or under hormonal influence?"], "properties": ["Is there a high level of estrogen receptor protein expression with variable levels of other biomarkers?", "Does the tumor tissue show generally low lipid content?", "Is the tumor cell density moderate compared to other breast cancer subtypes?"], "relational": ["Does the image show a lesion affecting glandular epithelial tissue, such as that found in the breast?", "Can you see a mass arising from or located within the mammary gland?", "Is there evidence of invasion into the chest wall, lungs, liver, or bones?"], "contexual_behavior": ["Is there evidence of altered immune evasion strategies in a tumor during immunosuppression?", "Does the image indicate impaired DNA repair mechanisms in a tumor under oxidative stress?", "Can you identify a tumor that could become less responsive to hormone therapy after prolonged treatment?"], "functions": ["Does the image show a carcinoma that might interact with stromal or immune cells, or remodel the extracellular matrix within the tumor microenvironment?", "Can you identify a tumor that could activate cell proliferation and survival pathways in response to hormonal cues?", "Is there a carcinoma that might modulate apoptosis by increasing anti-apoptotic gene expression through hormone receptor signaling?"]}}, "foramen magnum stenosis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show an opening at the base of the skull with a diameter less than 19 mm?", "Can you identify a structure whose cross-sectional area appears to be less than 3.5 cm\u00b2?", "Is there an opening with a width between 15 mm and 19 mm visible in the image?", "Does the image suggest a narrowing of an opening at the skull base by more than 20\u201330% compared to typical dimensions?", "Can you see an opening that appears more oval or constricted rather than round?", "Is there evidence of bone margins around an opening that are thicker than 5 mm?", "Does the volume of the opening at the base of the skull appear to be less than 5 cm\u00b3?", "Is the sagittal diameter of the visible opening less than 30 mm?", "Can you identify an opening with a transverse diameter less than 25 mm?", "Does the bone tissue surrounding the opening appear thickened, sclerotic, or dysplastic?", "Is there an area where bone density seems increased, potentially above 1200 Hounsfield units on CT imaging?", "Does the image suggest changes that are more likely to be found in infants or young children?", "Is there a visible narrowing of the opening at the skull base accompanied by thickened bone margins and crowding of neural structures?", "Can you see any indication that the flow of cerebrospinal fluid through the opening is significantly reduced, possibly below 2 ml/min?"], "relational": ["Is there evidence of narrowing at the interface between the skull base and the upper cervical spine?", "Can you identify changes affecting the posterior cranial fossa or craniovertebral junction?", "Does the image show alterations in the occipital bone, such as thickening or abnormal shape?", "Is there visible compression or reduced space for the medulla oblongata or spinal cord at the skull base?", "Are the cerebellar tonsils or lower brainstem positioned unusually close to the bony margins of the craniovertebral junction?", "Can you see any abnormal relationship between the atlas (C1) and the base of the skull?", "Is there evidence of narrowing that could affect the passage of the accessory nerve (CN XI) or other neural structures?", "Are the dura mater, arachnoid mater, or pia mater visibly compressed or distorted near the craniovertebral junction?", "Do the vertebral arteries or spinal arteries appear constricted or displaced near the skull base?", "Is there bony narrowing or thickening in the region of the clivus, occipital condyles, or jugular tubercles?", "Can you observe features suggesting neural compression at the junction of the skull and cervical spine?"], "contexual_behavior": [], "functions": ["Does the image show evidence of compression affecting neural or vascular structures that could result in neurological deficits?", "Is there a visible restriction of cerebrospinal fluid flow that might increase the risk of hydrocephalus or elevated intracranial pressure?", "Can you identify any signs of compression at the lower brainstem or upper spinal cord that could disrupt neural signal transmission?", "Does the image reveal pressure on regions responsible for autonomic or motor control, suggesting impaired brainstem function?", "Is there any indication of compromised respiratory control due to compression of medullary centers involved in breathing regulation?", "Can you observe any narrowing that might impede blood flow between the brain and spinal cord, such as compression of vertebral arteries or venous pathways?", "Are there visual cues indicating deficits in motor or sensory pathways, possibly due to compression at the cervicomedullary junction?", "Does the image suggest disruption of neural pathways that control cardiovascular or respiratory systems, pointing to possible autonomic dysfunction?", "Is there evidence of blockage at the craniospinal junction that could contribute to the development of hydrocephalus?", "Can you see any features that might indicate compression of cranial nerves or brainstem nuclei involved in swallowing or vocalization?"]}, "no_questions": {"contexual_properties": ["Is there evidence of increased blood vessels or vascularity on the outer covering of the head, as might occur with inflammation or neoplastic processes?", "Is there flakiness present on the head\u2019s surface, suggesting excessive desquamation?", "Does the image show thinning of the outermost layer of the head, possibly due to aging or nutritional deficiency?"], "properties": ["Can you observe variations in pigmentation that might reflect different levels of melanin concentration?", "Is there a region that could have a surface area between 500 and 700 square centimeters in adults?", "Is there evidence of a surface with a hair density of approximately 100 to 150 hairs per square centimeter?"], "relational": ["Are there visible regions adjacent to the main area, such as the temples or upper part of the auricular region?", "Can you identify any bones such as the frontal, parietal, temporal, or occipital bones in the depicted view?", "Does the image contain sensory structures such as hair follicles, sebaceous glands, or sweat glands?"], "contexual_behavior": ["Can you observe differences in pigmentation or signs of sunburn that might reflect varying responses to UV exposure based on skin type or melanin content?", "Does the image suggest any sensory impairment, such as changes in skin texture or appearance, that might be associated with neuropathy or nerve damage?", "Is there any indication of temperature regulation, such as vasoconstriction or vasodilation, in response to environmental extremes like cold or heat?"], "functions": ["Is there evidence of a structure that aids in temperature regulation of the head through a rich blood supply or sweat glands?", "Is there a layer that interacts with the underlying skull by providing shock absorption and reducing force transmission to bone?", "Does the image display a region that supports hair growth by anchoring hair follicles and providing vascularization?"]}}, "foramen magnum": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an opening located centrally at the base of the occipital bone in the image?", "Can you identify an oval or elliptical structure at the skull base?", "Does the image show an aperture with an area between 700 and 900 square millimeters?", "Is there a foramen with a diameter close to 35 millimeters visible in the image?", "Can you see an opening with a circumference of about 100 millimeters?", "Is there a structure oriented obliquely, facing downward and slightly forward at the base of the skull?", "Does the image display an aperture with a height around 30 millimeters?", "Can you identify an opening with a width between 27 and 30 millimeters?", "Is there a visible distance of approximately 10 to 12 millimeters between the central opening and the occipital condyles?", "Does the bone surrounding the central opening appear to have a thickness between 5 and 10 millimeters?", "Is there a smooth, well-defined margin bordered by the occipital bone around the central aperture?", "Can you observe a smooth and regular surface texture on the margin of the opening at the skull base?", "Does the image suggest developmental variation in the size of the central skull base opening, such as differences between infants and adults?"], "relational": ["Can you identify a large opening within the occipital bone?", "Is there a structure located in the posterior cranial fossa of the skull?", "Does the image show an area where the medulla oblongata passes through?", "Can you see a region that allows passage of vertebral arteries?", "Is there an opening through which spinal accessory nerves and meninges traverse?", "Does the image include a feature adjacent to the clivus or jugular tubercles?", "Can you identify a structure near the occipital condyles?", "Is there an area where the lower brainstem or spinal cord could be seen passing?", "Can you see a location where cranial nerve XI might traverse?", "Does the image show attachment points for the tectorial membrane or alar ligaments?", "Is there a visible connection between the cranial cavity and the vertebral canal?", "Can you identify a region that enables continuity between the brain and spinal cord?", "Does the image include vascular structures such as the anterior or posterior spinal arteries near a large cranial opening?"], "contexual_behavior": ["Does the image show evidence of neural compression at the craniovertebral junction, as might occur in congenital malformations?", "Is there any indication of cerebellar tonsillar herniation through an opening at the skull base, suggesting impaired cerebrospinal fluid flow?", "Can you identify signs of brain tissue herniation into the upper spinal canal that could be associated with raised intracranial pressure?", "Is there visible trauma or fracture near the craniovertebral junction that could compromise brainstem protection?", "Does the image reveal a mass or lesion at the skull base that might compress the spinal cord?", "Are there signs of bony overgrowth at the base of the skull that could narrow an aperture and impair vascular flow?", "Can you detect features suggestive of craniovertebral instability, possibly related to connective tissue disorders?", "Is there any abnormality in the size or shape of the opening at the skull base that could indicate a growth disorder or altered skeletal development?", "Does the image show swelling or inflammatory changes near the craniovertebral junction that could obstruct neural passage?", "Are there features of bone weakening or degeneration at the skull base that might reduce structural protection for neural elements?"], "functions": ["Does the image show an opening at the base of the skull that allows passage between the cranial cavity and vertebral canal?", "Can you identify a structure that enables direct anatomical continuity between the brain and spinal cord?", "Is there a visible feature that permits neural tissue to pass from the brainstem into the spinal cord?", "Does the image contain an opening that supports the transition of motor and sensory tracts from the brain to the spinal cord?", "Can you see a structure that allows the vertebral arteries and accessory nerve to pass between the cranial and spinal compartments?", "Is there an anatomical feature that physically links the intracranial and spinal neural compartments, supporting central nervous system connectivity?", "Does the image show a bony boundary at the skull base that helps protect the brainstem and spinal cord during head movement?", "Can you identify an opening that facilitates cerebrospinal fluid flow between the cranial and spinal subarachnoid spaces?"]}, "no_questions": {"contexual_properties": ["Does the image reveal abnormal surface texture, possibly indicating dysplasia or metaplasia?", "Are erosions present that might be caused by NSAID injury or infectious colitis?", "Does the image reveal abnormal tissue growth such as neoplasms, polyps, or granulation tissue?"], "properties": ["Does the image appear to have high sharpness, allowing for detailed visualization of mucosal surfaces?", "Can you assess whether the contrast ratio in the image is within the typical range of 300:1 to 1000:1?", "Is there evidence that the color balance setting is either auto white balance or manually adjusted?"], "relational": ["Is the visualized area part of a system like the digestive, respiratory, urinary, or reproductive system?", "Can you identify blood vessels or lesions within the visualized area?", "Can you see tissues such as epithelial, connective, or lymphoid tissue in the image?"], "contexual_behavior": [], "functions": ["Is there visual information that could support immediate clinical assessment or decision-making regarding internal organs?", "Can you observe features that would allow for real-time monitoring of disease progression or assessment of pathological changes over time?", "Can you see visual cues that might help evaluate the effectiveness of a previous treatment or intervention?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a structure connected to the middle or posterior cranial fossae?", "Is there a portion of the temporal bone that appears petrous in the image?", "Is there an area located within the cranial base visible in the image?"], "contexual_behavior": ["Does the image suggest vascular compression or thrombosis adjacent to the bone, which could be caused by inflammation?", "Can you identify features that might indicate compromised pressure equalization, such as those seen in barotrauma or with middle ear effusion?", "Can you see signs of bone erosion that might result from persistent inflammation in chronic otitis media?"], "functions": ["Does the image show a dense bony structure that provides protection to delicate neurovascular or sensory components within the temporal region?", "Can you identify foramina or canals within a bony surface that allow passage of blood vessels or cranial nerves, such as the internal carotid artery or cranial nerves VII and VIII?", "Can you identify a barrier that encases and safeguards the cochlea and vestibular apparatus of the inner ear?"]}}}
[ { "answer": "due to subluxation atlas vertebra case 31", "extracted_concepts": [ "stenosis of foramen magnum", "subluxation", "foramen magnum", "atlas vertebra" ], "question": "why does this image show stenosis of foramen magnum?" }, { "answer": "stenosis of foramen magnum due to subluxation of atlas vertebra case 31", "extracted_concepts": [ "stenosis of foramen magnum", "subluxation of atlas vertebra" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "stenosis of foramen magnum", "atlas vertebra", "foramen magnum", "subluxation of atlas vertebra" ], "question": "does this image show stenosis of foramen magnum due to subluxation of atlas vertebra case 31?" }, { "answer": "no", "extracted_concepts": [ "atlas vertebra", "stenosis of foramen magnum", "subluxation of atlas vertebra", "nodular tumor", "foramen magnum" ], "question": "does nodular tumor show stenosis of foramen magnum due to subluxation of atlas vertebra case 31?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "marfans syndrome" ], "question": "is marfans syndrome present?" }, { "answer": "rheumatoid arthritis", "extracted_concepts": [ "rheumatoid arthritis" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "rheumatoid arthritis" ], "question": "is rheumatoid arthritis present?" }, { "answer": "no", "extracted_concepts": [ "metastatic malignant melanoma" ], "question": "is metastatic malignant melanoma present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "rheumatoid arthritis", "extracted_concepts": [ "rheumatoid arthritis" ], "question": "what is present?" } ]	["atlas vertebra", "stenosis of foramen magnum", "bone", "subluxation of atlas vertebra", "rheumatoid arthritis", "calvarium", "marfans syndrome", "nodular tumor", "foramen magnum", "metastatic malignant melanoma", "subluxation"]	{"atlas vertebra": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a ring-shaped, oval bone structure visible in the image?", "Can you identify a bone that lacks a vertebral body?", "Does the image show a structure with approximately three foramina, including two transverse openings?", "Is there a bone present with a vertebral foramen diameter of about 2.5 cm?", "Can you see a structure with transverse processes measuring around 2 cm in length?", "Is there a bone with minimal curvature, maintaining a nearly flat ring appearance?", "Does the image contain a structure with a width of about 4 cm and a height of approximately 2.5 cm?", "Can you identify a bone whose thickness ranges from 0.5 to 1 cm?", "Is there a structure with a smooth surface and slightly rough areas where muscles might attach?", "Does the image show a bone with an off-white to pale yellow coloration?", "Is there a structure composed of both cortical and cancellous bone tissue?", "Can you see a bone with a typical volume of 8 to 10 cubic centimeters?", "Is there a structure with a bone density between 1.2 and 1.5 grams per cubic centimeter?", "Does the image include a bone with a porosity of around 5 to 15 percent?", "Can you identify a structure whose mineral content is predominantly hydroxyapatite, making up about 60 to 70 percent of its dry weight?", "Is there a bone present with a water content of approximately 10 to 20 percent by weight?", "Does the image show a structure with cartilage on its articular surfaces that is about 1 to 2 millimeters thick?", "Can you see a bone containing cells such as osteocytes, osteoblasts, and osteoclasts?", "Is there a structure with an average weight of about 20 grams?"], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Is there a bone in the cervical region of the spine visible in the image?", "Can you identify a vertebra that articulates with both the occipital bone and another cervical vertebra?", "Does the image contain a joint that enables head rotation, such as a pivot joint between two cervical vertebrae?", "Is there evidence of the atlanto-occipital or atlanto-axial joint present in the image?", "Can you see ligaments such as the transverse ligament, alar ligaments, or anterior longitudinal ligament attached to a cervical vertebra?", "Is there a vertebra in the image that lacks a vertebral body and spinous process but has large lateral masses?", "Does the image show passageways for the spinal cord, vertebral arteries, or spinal nerves near the upper cervical spine?", "Can you identify attachment sites for muscles like the rectus capitis anterior, rectus capitis lateralis, or obliquus capitis superior on a cervical vertebra?", "Is there a structure associated with the first cervical spinal nerve or the suboccipital nerve visible in the image?"], "contexual_behavior": ["Does the image show a cervical structure whose support for head movement appears compromised, possibly due to fracture or ligament injury?", "Is there evidence of decreased stabilization of the upper cervical spine, as might be seen after trauma or in inflammatory disease?", "Can you identify a vertebral element that fails to protect the spinal cord effectively in the presence of dislocation or severe fracture?", "Does the image suggest impaired head rotation, such as might occur in atlantoaxial subluxation or arthritis?", "Is there a sign that cranial weight distribution is altered, as could happen after a Jefferson fracture or compressive injury?", "Can you see excessive movement or instability in the upper cervical region, possibly due to torn or absent ligaments?", "Does the image reveal decreased neck flexibility, as might be associated with osteoarthritis or spondylosis?", "Is there evidence that vertebral artery flow could be compromised by subluxation, fracture, or vascular compression in the cervical region?", "Can you observe weakened support for the occipital condyles, such as might occur in rheumatoid arthritis with ligamentous erosion?", "Does the image show diminished ability to absorb mechanical stress in the upper cervical vertebrae, possibly due to fracture or bone loss?", "Is there restriction of head nodding movement, as might be seen in cases of meningitis or local synovitis?", "Can you detect altered cervical alignment, such as might result from atlas hypoplasia or congenital fusion anomalies?", "Does the image suggest decreased protection for neural structures in the cervical spine, as could occur with osteoporosis and increased fracture risk?", "Is there visible limitation of movement in the upper cervical region due to muscular spasm, such as in torticollis or cervical muscle strain?", "Can you see changes in head tilt facilitation, possibly related to ligamentous laxity from connective tissue disorders or trauma?"], "functions": ["Is there a structure in the image that supports the skull and facilitates head movement?", "Can you identify an anatomical feature that forms a joint with the occipital bone to allow the head to move up and down?", "Does the image show a structure that contributes to neck mobility and cervical flexibility?", "Is there an object that, together with another vertebra, enables rotation of the head through a specialized joint?", "Can you see a structure that articulates with the occipital condyles to enable nodding motions?", "Is there a bony ring encircling and protecting the upper portion of the spinal cord as it transitions from the brain to the vertebral column?", "Does the image contain a structure that transmits forces between the skull and cervical spine by distributing loads?", "Can you identify an anatomical feature that helps maintain posture by supporting the alignment of the head on the cervical spine?", "Is there a structure that assists in stabilizing the head through strong ligamentous and bony connections with the skull and another vertebra?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see extracellular matrix components like collagen, laminin, or fibronectin surrounding skin structures?", "Does the image show features associated with the regeneration or maintenance of hair follicles?", "Is there evidence of structures such as hair follicles or sebaceous glands?"], "contexual_behavior": ["Are there visual cues of decreased regenerative activity or diminished repair potential that could be linked to prolonged stress?", "Is there evidence of rapid tissue turnover or hyperproliferation, such as increased cell division after injury?", "Is there evidence of enhanced cellular differentiation or protective adaptation in response to UV exposure?"], "functions": ["Does the image show evidence of cells that are actively maintaining or repairing skin tissue?", "Can you identify areas where new keratinocytes or other skin cell types are being generated after injury or normal turnover?", "Is there visual indication of cell migration or proliferation at a wound site, suggesting restoration of the epidermal barrier?"]}}, "stenosis of foramen magnum": {"yes_questions": {"contexual_properties": ["Does the image show evidence of a cranial opening with a reduced diameter that could be due to abnormal bone development or genetic disorders?", "Is there a visible narrowing of a skull base structure that might be associated with conditions like achondroplasia or craniosynostosis?", "Can you identify irregular bone growth at the base of the skull that could indicate disorders such as osteopetrosis or Paget\u2019s disease?", "Is there an opening in the skull that appears to have an irregular or asymmetric shape, possibly due to congenital malformation or bone remodeling?", "Does the image reveal compression of a cranial aperture caused by excessive bone formation, tumor presence, or herniation of nearby tissues?", "Is there thickening of the margins of a large skull opening that could suggest chronic bone stress, metabolic bone disorder, or a genetic syndrome?", "Can you see loss of normal roundness in a cranial foramen, potentially resulting from asymmetric bone deposition or developmental anomalies?", "Is there a reduction in the cross-sectional area of a skull base opening, possibly due to congenital stenosis or progressive bone thickening?", "Does the image display bony overgrowth at the cranial base that might be linked to mucopolysaccharidosis or sclerotic bone disease?", "Is there decreased flexibility or increased rigidity of a skull opening, potentially due to increased ossification or calcification of surrounding ligaments?", "Can you observe increased bone density in the region of a cranial foramen, which could be associated with metabolic bone disorders or sclerosing dysplasias?", "Is there evidence of structural deformity in a skull base opening that could result from genetic mutation, trauma, or chronic disease?", "Does the image show obstruction of a cranial aperture by soft tissue, such as meningeal thickening, tumor, or inflammation?", "Is there visible calcification around a skull base opening that might be due to chronic inflammation, metabolic disturbance, or aging?", "Can you detect changes in the size of a cranial foramen that could be attributed to growth, development, or pathological processes like bone dysplasia?"], "properties": ["Is there a region at the base of the skull where the opening appears narrowed by approximately 30% to 60% compared to typical anatomy?", "Can you identify an opening whose diameter is visibly less than 20 mm?", "Does the image show a structure at the cranial base that appears oval or irregular instead of round?", "Is there an area where the cross-sectional opening is reduced to less than 200 mm\u00b2?", "Can you see a segment at the cranial base where the narrowed portion measures between 5 and 15 mm in length?", "Is there evidence of increased bone thickness, measuring between 5 and 10 mm, at the margins of a cranial opening?", "Does the image suggest a reduction in the volume of a cranial opening by approximately 30% to 50%?", "Is there a feature where the flow of cerebrospinal fluid through an opening appears diminished, potentially less than 5 ml/min?", "Can you observe thickened bone or fibrous tissue at the site of a narrowed cranial opening?", "Is there an indication of an elevated pressure gradient, possibly exceeding 5 mmHg, across a constricted opening at the base of the skull?"], "relational": ["Does the image show any abnormal narrowing at the craniovertebral junction or skull base?", "Is there evidence of constriction in the opening formed by the occipital bone?", "Can you see any compression of structures such as the medulla oblongata or vertebral arteries as they pass through the base of the skull?", "Does the image suggest an impact on the nervous or musculoskeletal systems at the junction between the skull and vertebral column?", "Are there visible changes to tissues like dura mater, bone, or connective tissue surrounding the large opening at the skull base?", "Is there any indication of altered passage where the spinal cord connects to the brainstem?", "Can you observe displacement or crowding of cranial structures such as the cerebellar tonsils or clivus near the skull base?", "Does the image reveal any abnormalities involving ligaments like the tectorial membrane or alar ligaments in the region where the skull meets the spine?", "Is there evidence of compression or impingement on nerves such as the spinal accessory nerve or upper cervical spinal nerves near the craniovertebral junction?", "Can you identify any disruption in the anatomical connection between the skull and vertebral column at the large opening at the skull base?"], "contexual_behavior": [], "functions": ["Does the image show evidence of compression affecting neural or vascular structures at the base of the skull?", "Is there a visible narrowing that could obstruct cerebrospinal fluid flow and increase the risk of hydrocephalus?", "Can you identify features suggesting compression of the lower brainstem or upper cervical spinal cord?", "Does the image reveal signs that could indicate impaired brainstem function, such as potential autonomic or cranial nerve involvement?", "Is there evidence of compromised blood flow to the brain or spinal cord, such as compression of vertebral arteries or venous pathways?", "Can you see any abnormality that might impinge on the medulla oblongata or upper cervical spinal cord?", "Does the image suggest possible disruption of respiratory or cardiovascular regulation due to brainstem involvement?", "Is there a structural alteration that could interfere with normal craniospinal pressure dynamics or suggest the presence of syringomyelia?", "Can you identify changes that might be associated with motor weakness, sensory loss, ataxia, or difficulty swallowing?", "Does the image show narrowing that could impede the passage of cranial nerves responsible for swallowing, vocalization, or shoulder movement?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure where myoepithelial cells are present around an abnormal proliferation?", "Can you identify an area where an intact basement membrane separates abnormal cells from surrounding stromal tissue?", "Is there evidence of a process arising within the ductal epithelium of the breast?"], "contexual_behavior": [], "functions": ["Does the image reveal loss of cell polarity or abnormal arrangement of epithelial cells within a duct?", "Is there an area where the organization of epithelial cells within a duct seems disrupted?", "Is there evidence of abnormal signaling or loss of growth control within a ductal epithelial population?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Does the image show areas where tissue expansion suggests tumor progression or inflammation?", "Do you observe disruption of normal tissue patterns, suggesting neoplastic or dysplastic changes?", "Can you see areas where the tissue surface is lost or eroded, indicating ulceration or chronic inflammation?"], "properties": ["Does the image contain a rectangular object with high optical clarity suitable for microscopy?", "Can you identify a transparent or colorless item, possibly with a frosted end?", "Is there an item present that would weigh around 5 grams?"], "relational": ["Are there adjacent slides or specimens, such as control slides or immunohistochemistry slides, visible in the image?", "Are there visible cellular components such as epithelial cells, inflammatory cells, neoplastic cells, or stromal cells?", "Is there a structure present that could represent skin, lymph nodes, mucosa, or an organ?"], "contexual_behavior": ["Does the image show evidence of increased cellular activity that could indicate inflammation or immune cell recruitment?", "Is there evidence of poor blood vessel formation or maintenance that could suggest impaired vascularization in the context of diabetes?", "Can you detect a reduced inflammatory response, such as fewer immune cells or suppressed cytokine activity, possibly following corticosteroid treatment?"], "functions": ["Are there features such as atypical cells, increased mitotic figures, or areas of necrosis visible, suggesting abnormal cellular activity?", "Does the image reveal alterations in cellular morphology or lesion characteristics that could reflect a response to therapy?", "Does the image show a sample prepared for microscopic examination to aid in tissue analysis or medical diagnostics?"]}}, "rheumatoid arthritis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of joint swelling affecting between 4 and 10 joints?", "Can you identify signs of tenderness in 6 to 12 joints?", "Is there visible morning stiffness that appears to last longer than 60 minutes?", "Does the image display subcutaneous nodules in approximately 20 to 30% of the individuals shown?", "Are there radiographic features indicating mild to moderate joint erosions, with scores that might fall between 10 and 50 on the Sharp/van der Heijde scale?", "Can you observe any extra-articular manifestations present in about 40% of the depicted cases?", "Is there visual evidence suggesting a disease duration spanning 10 to 20 years?", "Does the image suggest the presence of anemia, with hemoglobin levels likely between 10 and 12 g/dL?", "Are there indications of elevated synovial fluid white blood cell counts, possibly ranging from 5,000 to 50,000 cells/\u03bcL?", "Can you infer that the average age of onset for the condition in the individuals shown is between 30 and 60 years?", "Is there evidence suggesting moderate to high disease activity, with a disease activity score (DAS28) likely between 3.2 and 5.1?"], "relational": ["Does the image show evidence of a condition affecting both the musculoskeletal and immune systems?", "Can you identify abnormalities in joints such as those of the hands, wrists, feet, or knees?", "Is there visible damage to structures like the synovial membrane, cartilage, ligaments, or bone within a joint?", "Does the image display chronic inflammation of the tissue lining a joint cavity?", "Are there signs of connective tissue involvement, such as changes in the synovium, tendons, or ligaments?", "Can you see structural alterations in bones such as the phalanges, metacarpals, or carpal bones?", "Is there evidence of joint deformity or bone erosions in the regions commonly affected by autoimmune processes?", "Does the image reveal features like synovial hyperplasia or cartilage erosion within a joint?", "Are there indications of an autoimmune process targeting joint tissues?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Does the image show a change in color, such as bluish, yellowish, or pale tones, which could be related to cyanosis, jaundice, anemia, or recent food or medication intake?", "Is there increased redness that could suggest inflammation, infection, or vitamin deficiency?", "Can you observe pigmentation changes that might be related to Addison's disease, Peutz-Jeghers syndrome, or medication effects?"], "properties": ["Is there evidence of tissue with a thickness ranging from 0.5 to 2 millimeters?", "Does the image contain a structure that could contain 32 mineralized elements primarily composed of hydroxyapatite?", "Is there a region likely to contain stratified squamous epithelial cells, mucous cells, and taste receptor cells?"], "relational": ["Does the structure shown have a posterior continuity with the pharynx, serving as its anterior opening?", "Does the image contain organs such as the tongue or teeth?", "Is there a separation between the oral space and the nasal cavity by the hard or soft palate?"], "contexual_behavior": ["Does the structure show delayed wound healing, as might be seen in diabetes with impaired regeneration?", "Is there visible accumulation of plaque or debris that could indicate poor cleansing function due to inadequate oral hygiene?", "Can you see features that suggest increased antimicrobial activity, such as during an oral infection?"], "functions": ["Can you see features associated with the presence of digestive enzymes like amylase?", "Can you observe features that help regulate pH, moisture, or microbial balance in the oral cavity?", "Does the image display a region where saliva is produced or secreted?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Do you observe asymmetrical limb lengths that could be due to uneven musculoskeletal development or differential limb usage?", "Can you see a difference in head circumference between the two individuals, which could suggest unequal cranial development or hydrocephalus?", "Is there a change in skin texture at the junction, such as areas of scarring or chronic friction?"], "properties": ["Can you identify a case where there is thoracic, abdominal, pelvic, or cranial fusion between two individuals?", "Is there visual evidence of organ sharing, such as a single liver or heart serving both bodies?", "Can you observe asymmetry or partial symmetry in the distribution of body parts between the two connected bodies?"], "relational": ["Do you observe tissues such as skin, muscle, or bone forming a bridge between two individuals?", "Are there skeletal elements, such as the sternum, vertebrae, pelvic bones, or skull, that appear joined between two bodies?", "Can you see duplication or sharing of organs like the intestines, kidneys, or bladder between two connected bodies?"], "contexual_behavior": ["Does the depicted anatomy imply that a shared nervous system could alter pain perception or sensory processing?", "Is there evidence of shared excretory organs, such as kidneys or bladder, that might impair waste elimination for both individuals?", "Can you see features that imply a shared digestive tract, which could affect nutrient absorption?"], "functions": ["Can you identify overlapping tissues or organs that could result in increased susceptibility to infection or autoimmune reactions?", "Does the image suggest the presence of integrated systemic regulation or compensatory organ function to maintain physiological balance?", "Does the image suggest the need for complex motor coordination or voluntary cooperation between two bodies?"]}}, "marfans syndrome": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show abnormalities in the cardiovascular system, such as changes to the aorta or heart valves?", "Can you identify any skeletal features, such as unusually long bones or spinal curvature, that might indicate involvement of the skeletal system?", "Is there evidence of alterations in connective tissues, such as changes in the appearance of elastic fibers or extracellular matrix?", "Does the image reveal structural changes in the ascending aorta or aortic root?", "Can you observe any abnormalities in the heart valves?", "Are there visible differences in the ribs or spine that could suggest a connective tissue disorder?", "Does the image show any features of the ocular system, such as lens displacement or changes in the zonules or sclera?", "Is there evidence of aortic dilation, aneurysm, or dissection present in the cardiovascular structures?", "Can you see any joint abnormalities, such as hypermobility or unusual structure in the knees, elbows, fingers, or wrists?", "Are there visible changes in the chest or thoracic region that might be associated with a connective tissue disorder?", "Does the image show any abnormalities in vascular tissue that could indicate altered elasticity?", "Can you identify any regions of the body, such as the eyes or cardiovascular tract, that appear structurally impacted?"], "contexual_behavior": ["Does the image show evidence of impaired connective tissue function, particularly in areas experiencing rapid growth or mechanical stress?", "Is there a visible indication of increased risk for aortic dissection, especially in the context of physical exertion or elevated blood pressure?", "Can you identify signs of joint laxity that might be more pronounced during hormonal changes such as pregnancy?", "Does the image suggest reduced cardiovascular resilience, possibly in response to physical or emotional stress?", "Is there evidence of ocular lens dislocation that could be exacerbated by trauma or sudden increases in intraocular pressure?", "Can you observe features indicating impaired pulmonary function, such as signs of pneumothorax or reduced lung elasticity, particularly during respiratory infection?", "Does the image reveal decreased bone strength or abnormalities in bone matrix integrity, especially during periods of growth spurts?", "Is there a visible indication of mitral valve dysfunction that appears more pronounced with aging or connective tissue degeneration?", "Can you identify signs of scoliosis progression, particularly during adolescence or periods of rapid skeletal growth?", "Does the image suggest reduced wound healing efficiency, possibly following surgery, that could be related to impaired collagen synthesis?", "Is there evidence of altered cardiovascular function, such as aortic dilation or dissection, in the presence of hypertension?", "Can you observe indications of impaired physical endurance or musculoskeletal abnormalities that might affect exercise capacity?", "Does the image show signs of pneumothorax that could be associated with rapid altitude changes and fragile lung tissue?", "Is there evidence of worsened aortic dilation during pregnancy, possibly due to increased blood volume and cardiac output?", "Can you identify musculoskeletal features such as disproportionate limb elongation or joint instability, especially during periods of rapid growth?"], "functions": ["Does the image show evidence of widespread dysfunction in connective tissues affecting multiple organ systems?", "Can you identify features that suggest a deficiency in fibrillin-1, such as weakened connective tissue structures?", "Is there visual evidence of cardiovascular abnormalities, such as dilation of the aorta or irregularities in heart valves?", "Does the image reveal decreased elasticity or fragility in blood vessels, making them appear more susceptible to dilation or rupture?", "Are there skeletal features present, such as unusually long limbs, scoliosis, or chest wall deformities?", "Can you observe signs of ocular abnormalities, such as lens displacement or indications of nearsightedness?", "Is there any indication of a weakened aortic wall, such as signs of aneurysm formation or dissection?", "Does the image suggest increased joint mobility or instability, such as hyperextended joints or lax ligaments?", "Are there features consistent with lung complications, such as evidence of a collapsed lung or reduced lung expansion?", "Can you see abnormalities in heart valve structure or function, such as prolapse or regurgitation of the mitral valve?", "Is there evidence of tall stature or limbs that appear disproportionately long compared to the torso?", "Does the image suggest a reduced ability to withstand physical stress, such as signs of tissue fragility or increased risk of organ rupture?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a cranial vault that lacks the typical segmentation seen in normal skull anatomy?", "Is there evidence of a skull without visible sutures separating individual bones?", "Does the image show a cranial structure where the bones appear to be fused into a single unit?"], "relational": ["Does the image show a structure that is part of the skeletal system and forms the superior and lateral boundaries of the cranial cavity?", "Does the image show the absence of normal cranial sutures such as the coronal, sagittal, or lambdoid sutures?", "Can you identify membranes such as dura mater, arachnoid mater, or pia mater associated with a bony enclosure?"], "contexual_behavior": ["Is there evidence of fusion among the bones that typically form the cranial vault?", "Can you identify a region of the skull that lacks visible sutures between its major components?", "Does the image show a structure where multiple cranial bones appear to be joined together as a single unit?"], "functions": ["Can you identify a feature that plays a role in shaping and enclosing the cranial cavity during development?", "Does the image show a rigid, continuous bony shell that could serve as a barrier against trauma to the brain?", "Is there a structure present that provides encasement and protection for the brain?"]}}, "nodular tumor": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a mass present within epithelial, connective, or glandular tissue in the image?", "Can you identify a lesion affecting organs such as the liver, thyroid, lung, breast, or skin?", "Does the image show a structure located in the subcutaneous layer, parenchymal region, or on the surface of an organ?", "Is there an area composed of neoplastic, stromal, or inflammatory cells visible?", "Can you see a mass surrounded by a fibrous capsule or adjacent parenchyma?", "Does the image show a structure compressing, invading, or being supplied by nearby blood vessels?", "Is there evidence of involvement of regional lymph nodes or lymphatic vessels near a mass?", "Can you identify a lesion with a defined capsule, infiltration margin, or interface with adjacent tissue?", "Does the image reveal a structure that could impact the endocrine, respiratory, or integumentary system?", "Is there a mass supported by fibrous stroma, blood vessels, or connective tissue visible in the image?"], "contexual_behavior": [], "functions": ["Does the image show an abnormal mass of proliferating cells with no apparent beneficial function?", "Is there a structure that appears to compress, infiltrate, or displace nearby tissues?", "Can you identify a mass that might be causing disruption to local tissue architecture or function?", "Is there evidence of altered cell proliferation or impaired cell death in any visible structure?", "Does the image contain a mass that could be inducing new blood vessel formation or compressing existing vessels?", "Is there a region that might be causing local ischemia or changes in blood supply?", "Can you see a structure that may be interfering with the normal function of an organ?", "Is there a mass that could be eliciting an immune response or showing signs of immune evasion?", "Does the image include a structure that might be activating oncogenic signaling or inhibiting tumor suppressor pathways?", "Is there evidence of uncontrolled cell division or resistance to growth-inhibitory signals in any visible mass?", "Can you identify a region that could be secreting factors to promote neovascularization?", "Is there a structure that appears to be altering the extracellular matrix or impairing normal tissue repair?", "Does the image show a mass that might be downregulating antigen presentation or secreting immunosuppressive molecules?", "Is there evidence of a modified local microenvironment, such as changes in stromal cells or cytokine profiles, surrounding a particular mass?"]}, "no_questions": {"contexual_properties": ["Does the image show epithelial changes in breast tissue that are more common with aging or fibrocystic alterations?", "Is there a noticeable alteration in staining characteristics, such as enhanced eosinophilia and granularity, in the cytoplasm?", "Do the epithelial cells exhibit features of altered secretory activity, such as apocrine-type secretion?"], "properties": ["Is there evidence of cells with round or polygonal shapes and mononuclear features?", "Do the cells display prominent cytoplasmic granularity, possibly due to secretory granules?", "Can you identify clusters or sheets of cells lining cystic spaces?"], "relational": ["Does the image contain structures adjacent to normal mammary ducts or lobules?", "Is there evidence of cells with abundant eosinophilic cytoplasm and prominent nuclei in the mammary gland region?", "Are there cysts or fibrocystic changes present near areas of altered epithelial cells in the breast tissue?"], "contexual_behavior": ["Does the image show any alterations in tissue function that might correspond to fluctuations in estrogen or progesterone levels?", "Are there areas displaying decreased functional differentiation, which might be indicative of neoplastic conditions and loss of normal regulatory mechanisms?", "Is there a visible decrease in epithelial barrier integrity in areas exposed to sustained tissue injury or inflammation?"], "functions": ["Is there evidence of increased cytoplasmic granularity or prominent nucleoli in epithelial cells, suggesting enhanced secretory activity?", "Does the image lack features associated with neoplasia or malignant transformation in breast tissue, supporting a benign nature of the observed changes?", "Is there visual evidence of a shift in epithelial cell phenotype that could affect the composition of glandular secretions?"]}}, "foramen magnum": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an opening located centrally at the base of the occipital bone in the image?", "Can you identify an oval or elliptical structure at the skull base?", "Does the image show an aperture with an area between 700 and 900 square millimeters?", "Is there a foramen with a diameter close to 35 millimeters visible in the image?", "Can you see an opening with a circumference of about 100 millimeters?", "Is there a structure oriented obliquely, facing downward and slightly forward at the base of the skull?", "Does the image display an aperture with a height around 30 millimeters?", "Can you identify an opening with a width between 27 and 30 millimeters?", "Is there a visible distance of approximately 10 to 12 millimeters between the central opening and the occipital condyles?", "Does the bone surrounding the central opening appear to have a thickness between 5 and 10 millimeters?", "Is there a smooth, well-defined margin bordered by the occipital bone around the central aperture?", "Can you observe a smooth and regular surface texture on the margin of the opening at the skull base?", "Does the image suggest developmental variation in the size of the central skull base opening, such as differences between infants and adults?"], "relational": ["Can you identify a large opening within the occipital bone?", "Is there a structure located in the posterior cranial fossa of the skull?", "Does the image show an area where the medulla oblongata passes through?", "Can you see a region that allows passage of vertebral arteries?", "Is there an opening through which spinal accessory nerves and meninges traverse?", "Does the image include a feature adjacent to the clivus or jugular tubercles?", "Can you identify a structure near the occipital condyles?", "Is there an area where the lower brainstem or spinal cord could be seen passing?", "Can you see a location where cranial nerve XI might traverse?", "Does the image show attachment points for the tectorial membrane or alar ligaments?", "Is there a visible connection between the cranial cavity and the vertebral canal?", "Can you identify a region that enables continuity between the brain and spinal cord?", "Does the image include vascular structures such as the anterior or posterior spinal arteries near a large cranial opening?"], "contexual_behavior": ["Does the image show evidence of neural compression at the craniovertebral junction, as might occur in congenital malformations?", "Is there any indication of cerebellar tonsillar herniation through an opening at the skull base, suggesting impaired cerebrospinal fluid flow?", "Can you identify signs of brain tissue herniation into the upper spinal canal that could be associated with raised intracranial pressure?", "Is there visible trauma or fracture near the craniovertebral junction that could compromise brainstem protection?", "Does the image reveal a mass or lesion at the skull base that might compress the spinal cord?", "Are there signs of bony overgrowth at the base of the skull that could narrow an aperture and impair vascular flow?", "Can you detect features suggestive of craniovertebral instability, possibly related to connective tissue disorders?", "Is there any abnormality in the size or shape of the opening at the skull base that could indicate a growth disorder or altered skeletal development?", "Does the image show swelling or inflammatory changes near the craniovertebral junction that could obstruct neural passage?", "Are there features of bone weakening or degeneration at the skull base that might reduce structural protection for neural elements?"], "functions": ["Does the image show an opening at the base of the skull that allows passage between the cranial cavity and vertebral canal?", "Can you identify a structure that enables direct anatomical continuity between the brain and spinal cord?", "Is there a visible feature that permits neural tissue to pass from the brainstem into the spinal cord?", "Does the image contain an opening that supports the transition of motor and sensory tracts from the brain to the spinal cord?", "Can you see a structure that allows the vertebral arteries and accessory nerve to pass between the cranial and spinal compartments?", "Is there an anatomical feature that physically links the intracranial and spinal neural compartments, supporting central nervous system connectivity?", "Does the image show a bony boundary at the skull base that helps protect the brainstem and spinal cord during head movement?", "Can you identify an opening that facilitates cerebrospinal fluid flow between the cranial and spinal subarachnoid spaces?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify a mucosal region that would likely have a slightly acidic pH, around 5.5\u20136.5?", "Can you see tissues such as cartilage, bone, mucosa, skin, or connective tissue within a single section?", "Does the image contain a section displaying pink to reddish coloration due to high vascularization?"], "relational": ["Can you identify an anatomical view that separates the left and right halves of both the external and internal nose?", "Can you see structures such as the nasal conchae or meatuses within a single nasal cavity?", "Does the image display tissues such as mucosa, cartilage, bone, and skin within the same section?"], "contexual_behavior": [], "functions": ["Does the image suggest a change that might impair the sense of smell by affecting the olfactory region or its airflow?", "Does the image show a loss of mucosal surface or barriers that would reduce the nasal cavity's filtration and humidification functions?", "Is there visible disruption of the mucosal lining that could compromise mucociliary clearance or increase infection risk?"]}}, "metastatic malignant melanoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of abnormal tissue in organs such as the skin, lungs, liver, brain, or bones?", "Can you identify lesions affecting the integumentary, respiratory, nervous, musculoskeletal, or gastrointestinal systems?", "Is there any indication of involvement of the lymphatic system, such as enlarged lymph nodes or lymphatic channels?", "Does the image reveal signs of tumor spread along lymphatic vessels, blood vessels, or through direct invasion of surrounding tissues?", "Can you see any abnormality originating from cutaneous, mucosal, or ocular regions?", "Is there evidence of disease affecting the trunk, extremities, head, or neck?", "Does the image display changes in lymphatic channels, blood vessels, or the extracellular matrix that might suggest cell dissemination?", "Are there visible abnormalities in regional lymph nodes that could indicate initial sites of metastatic spread?", "Can you identify secondary lesions in the lungs, liver, brain, or bones?", "Is there any indication that anatomical barriers such as the basement membrane, blood-brain barrier, or connective tissue septa have been breached by abnormal cells?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display fetal blood vessels linked to another structure?", "Is there a visible connection between a structure and the umbilical cord?", "Does the image show a barrier or layers separating maternal and fetal blood?"], "contexual_behavior": [], "functions": ["Does the image show features such as chorionic villi that regulate blood flow between maternal and fetal circulations?", "Can you identify a structure that regulates the transfer of maternal antibodies, such as immunoglobulin G, to the fetus?", "Is there an object involved in endocrine communication by releasing hormones into both maternal and fetal bloodstreams?"]}}}
[ { "answer": "mammographic detection of calcifications", "extracted_concepts": [ "mammographic detection of calcifications", "dcis" ], "question": "what is associated with dcis?" }, { "answer": "dcis", "extracted_concepts": [ "mammographic detection of calcifications", "dcis" ], "question": "what is mammographic detection of calcifications associated with?" }, { "answer": "yes", "extracted_concepts": [ "dcis", "mammographic detection", "calcifications" ], "question": "is mammographic detection of calcifications associated with dcis?" }, { "answer": "no", "extracted_concepts": [ "multiple cytoplasmic inclusions", "dcis", "distinct nuclear inclusion" ], "question": "is a distinct nuclear inclusion and multiple cytoplasmic inclusions associated with dcis?" } ]	["mammographic detection of calcifications", "distinct nuclear inclusion", "multiple cytoplasmic inclusions", "mammographic detection", "calcifications", "dcis"]	{"mammographic detection of calcifications": {"yes_questions": {"contexual_properties": ["Does the image show an increased number of small, bright spots that could be associated with ductal carcinoma in situ or a benign proliferative process?", "Are there larger, well-defined bright areas that might suggest the presence of a fibroadenoma or cyst degeneration?", "Can you identify clusters of bright spots that could indicate malignancy or a proliferative lesion?", "Does the image reveal irregularly shaped bright areas that might be seen in malignancy or atypical ductal hyperplasia?", "Are there regions with denser bright spots that could be related to metabolic disorders or chronic inflammation?", "Can you observe any changes in the distribution of bright spots that might suggest disease progression or recurrence?", "Does the image show new patterns of bright spots that could indicate the development of new lesions or evolving pathology?", "Are there bright spots of varying sizes that might reflect a mix of benign and malignant processes or ongoing lesion evolution?", "Can you see particularly bright calcifications that could be associated with sclerosing adenosis or dystrophic calcification?", "Are there bright spots with altered or indistinct margins that might suggest malignant transformation or atypical hyperplasia?", "Does the image show an increasing number of bright spots over time, possibly indicating neoplastic progression or chronic inflammation?", "Can you identify bright spots associated with areas of tissue distortion that could be due to invasive carcinoma or postsurgical changes?", "Are there regions where the density of bright spots changes, potentially reflecting evolving lesions or metabolic alterations?", "Does the image reveal bright spots appearing in new locations, which might be consistent with new pathological foci or metastatic spread?", "Can you observe bright spots with suspicious shapes or morphologies that could be seen in high-risk lesions or early-stage breast cancer?"], "properties": ["Does the image show multiple bright, highly radiopaque spots measuring less than 1 millimeter in size?", "Can you identify round, punctate, or irregularly shaped radiopaque foci in the image?", "Is there evidence of clustered, linear, or segmental arrangements of small, dense spots?", "Does the image display areas where the spacing between bright foci is less than 1 millimeter to several millimeters apart?", "Can you see one to three distinct clusters of high-density, radiopaque spots?", "Are there several dozen or fewer bright, punctate or amorphous structures visible?", "Do any of the bright spots have well-defined or indistinct margins?", "Is the average diameter of the individual radiopaque foci around 0.5 millimeters?", "Are there high-density, radiopaque features with sizes ranging from 0.1 to 2 millimeters present in the image?"], "relational": ["Does the image show small, dense areas within the breast parenchyma or ducts that could indicate mineral deposits?", "Can you identify any bright spots in regions such as the upper outer quadrant or subareolar area of the breast?", "Are there visible features within the ductal epithelium or lobular stroma that differ in density from surrounding fibroglandular tissue?", "Does the image appear to be acquired using digital mammography or tomosynthesis, as opposed to ultrasound or MRI?", "Can you distinguish between potential mineral deposits and other anatomical features like blood vessels, skin folds, or fat lobules?", "Is there evidence of small, clustered densities near the terminal duct lobular units or within the subareolar region?", "Do you observe any patterns of bright spots that seem to originate within ductal structures or lobular units?", "Are there anatomical landmarks such as the nipple, areola, or breast quadrants that help localize areas of increased density?", "Can you see structures like Cooper\u2019s ligaments, glandular tissue, or fat visualized alongside areas of increased radiodensity?", "Are there dense regions that appear to be connected to ductal walls, the stromal matrix, or adjacent lobules within the breast tissue?"], "contexual_behavior": ["Does the image show dense tissue that could reduce the visibility of small bright spots against the surrounding background?", "Is there evidence of digital image enhancement that might increase the contrast of tiny bright specks?", "Can you identify overlapping anatomical structures that could obscure or mimic the appearance of small calcified areas?", "Does the image appear to have been acquired after administration of a contrast agent, potentially increasing the distinction between vascular and non-vascular regions?", "Is there visual evidence of prior surgical intervention, such as scar tissue or altered anatomy, that could affect the detection of small bright deposits?", "Do you notice any motion artifacts, such as blurring or distortion, that might impair the identification of fine granular features?", "Are there clusters of tiny bright spots suggestive of an early radiographic sign in a context consistent with early-stage disease?", "Does the image appear to be from a younger individual, with denser tissue that could make the identification of small calcified areas less reliable?", "Is there an indication that tomosynthesis was used, such as multiple sectional images, which could reduce tissue overlap and enhance the conspicuity of small lesions?", "Can you observe tissue changes or fibrosis that might be consistent with prior radiation therapy and could obscure small bright deposits?", "Are there features suggestive of benign processes that could produce bright spots similar in appearance to those associated with malignant conditions, making diagnosis more challenging?", "Is there evidence that computer-aided diagnosis tools were applied to assist in highlighting subtle or clustered bright spots?", "Does the image exhibit technical limitations, such as low spatial resolution or poor image quality, that could reduce the effectiveness of identifying small calcified areas?", "Is there any indication that the image is from a high-risk patient under increased surveillance, such as the presence of multiple sequential images or targeted views?", "Can you see breast implants that might obscure or mask underlying small bright deposits, making their identification more difficult?"], "functions": ["Does the image reveal any features that could be critical for early detection during breast cancer screening?", "Can you identify small, bright spots that might indicate microcalcifications associated with early breast disease?", "Is there evidence of patterns or distributions that could help in recognizing malignant lesions?", "Does the image display clusters or morphologies that might assist in distinguishing between benign and malignant processes?", "Can you observe any changes in the number, size, or appearance of certain features that would be relevant for monitoring disease progression?", "Is there a region that could be localized for targeted sampling in a diagnostic procedure such as a biopsy?", "Does the image show changes that might be used to evaluate response to therapy or treatment?", "Are there patterns present that could contribute to assessing an individual's risk for developing breast cancer?"]}, "no_questions": {"contexual_properties": ["Does any region exhibit a change in texture, such as increased firmness or keratinization, that could be caused by fibrosis, keratinization, or edema?", "Is there evidence of loss of normal tissue architecture, possibly due to severe dysplasia or architectural disorganization?", "Is there a region that appears more vascularized, potentially as a result of angiogenesis stimulated by hypoxia or growth factors?"], "properties": ["Is there evidence of normal or slightly increased vascularity in any area compared to surrounding tissue?", "Is there a lesion whose density is similar to or slightly greater than that of the adjacent tissue?", "Does any lesion appear to have a smooth or slightly rough texture?"], "relational": ["Does the image show a localized area within an organ, organ subregion, or tissue compartment that appears distinct from the rest?", "Does the image show an area arising from epithelial, glandular, or mucosal tissue that appears different from the surrounding tissue?", "Is there a visible transition zone or interface between abnormal and healthy cells in the tissue?"], "contexual_behavior": ["Can you see evidence of deficient DNA repair, such as abnormal nuclear morphology, in a region that may have been exposed to mutagens?", "Is there a structure that seems to have impaired differentiation, perhaps in the context of altered hormone receptor signaling?", "Can you identify a region that may be at increased risk for malignant transformation if additional genetic or epigenetic alterations are acquired?"], "functions": ["Does the image show abnormal cell-to-cell communication or signs of local invasion into surrounding healthy tissue?", "Does the image show an area of abnormal tissue change that could indicate the early stages of disease initiation?", "Does the image reveal areas where gene expression appears altered or where normal cellular homeostasis might be disrupted?"]}}, "distinct nuclear inclusion": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a round or oval structure within the nucleus measuring between 1 and 5 micrometers in diameter?", "Can you identify an object inside the nucleus that appears eosinophilic or basophilic depending on the stain used?", "Does the image show a nuclear structure with a homogeneous or glassy staining pattern under hematoxylin and eosin?", "Is there a dense, smooth, and homogeneous object located centrally or near the periphery of the nucleus?", "Can you see a nuclear feature that appears electron-dense under electron microscopy?", "Is there a structure within the nucleus that has a higher refractive index than the surrounding nucleoplasm?", "Does the image contain a nuclear object with a high protein content, possibly consisting of aggregated or misfolded proteins?", "Can you observe a nuclear inclusion that may contain viral proteins, cellular proteins, or nucleic acids such as DNA or RNA?", "Is there typically one, but occasionally several, of these inclusions present within a single nucleus?", "Does the frequency of these nuclear structures vary among cells, possibly depending on the underlying disease process?"], "relational": ["Does the image show any intranuclear aggregates within the nuclei of cells?", "Can you identify structures located inside the nuclear matrix?", "Are there any features present within the nucleoplasm or perinucleolar space?", "Is there evidence of aggregates associated with the nucleolus or nuclear speckles?", "Do you observe inclusions in the nuclei of neurons, hepatocytes, or epithelial cells?", "Are there nuclear features visible in tissues such as brain, liver, or epithelial tissue?", "Can you see any nuclear changes in larger structures like the brain, liver, or skin?", "Are there intranuclear objects that appear near the endoplasmic reticulum or nucleolus?", "Does the image display nuclear inclusions alongside cytoplasmic or nucleolar inclusions?", "Can you identify nuclear structures composed of aggregated proteins, viral particles, or abnormal nucleic acids?"], "contexual_behavior": [], "functions": ["Does the image show a subnuclear structure that could be involved in compartmentalizing or regulating nuclear activities?", "Can you identify a nuclear feature that might modulate gene expression by sequestering transcription factors or altering chromatin organization?", "Is there evidence of a nuclear structure that could regulate processes such as transcription, RNA processing, or protein degradation?", "Does the image display a nuclear entity that might participate in the cellular stress response by accumulating misfolded proteins?", "Can you see a nuclear feature that could be involved in protein quality control by sequestering aberrant or misfolded proteins?", "Is there a nuclear structure present that might interfere with DNA replication or repair by trapping essential factors or altering nuclear architecture?", "Does the image contain a nuclear component that could modulate the availability and function of nuclear proteins through sequestration?", "Can you identify a nuclear feature that may contribute to the pathogenesis of neurodegenerative disorders or viral infections by disrupting normal nuclear functions?", "Is there a visible nuclear structure that could alter the spatial distribution of nuclear components and influence nuclear dynamics?", "Does the image show a nuclear entity that might affect the trafficking of proteins or RNAs between the nucleus and cytoplasm?"]}, "no_questions": {"contexual_properties": ["Does the tissue display changes in color, texture, or contour that could be attributed to altered cell proliferation?", "Can you observe an increase in the measurable volume of an organ or tissue, potentially due to expansion of cell populations?", "Can you identify regions with a higher than normal cell density within the tissue?"], "properties": ["Is there a section where the epithelial layer appears thicker than usual due to additional cell layers?", "Does the image show a region with a firmer or more nodular texture compared to surrounding tissue?", "Can you identify tissue that is similar in color to normal areas but may appear slightly paler or more vascular?"], "relational": ["Does the image display a compartment of the breast, adrenal cortex, or endometrium with boundaries defined by the tissue or organ capsule, showing signs of increased cell numbers?", "Is there an area within the integumentary system that shows signs of tissue enlargement due to cell proliferation?", "Is there a visible area where epithelial, glandular, or stromal cells appear more numerous than in adjacent tissue, but the overall architecture remains intact?"], "contexual_behavior": ["Is there evidence of increased tissue mass in regions typically affected by chronic hormonal stimulation, such as the endometrium?", "Can you identify regions where excessive cell proliferation could be causing tissue damage or dysfunction, as might occur in autoimmune diseases?", "Can you observe abnormal enlargement of an organ that could be associated with impaired function, as seen in disease states like benign prostatic enlargement?"], "functions": ["Does the image show compensatory growth, such as expansion of cell populations to restore organ mass or function?", "Does the image show evidence of increased cell numbers leading to tissue enlargement or altered function?", "Can you see structural changes that might indicate a physiological impact, either beneficial or pathological, due to increased cell numbers?"]}}, "multiple cytoplasmic inclusions": {"yes_questions": {"contexual_properties": ["Does the image show cells containing more than one distinct inclusion within their cytoplasm?", "Can you identify cellular structures that display multiple discrete bodies or deposits inside the cytoplasmic area?", "Is there evidence of cells with several internal inclusions rather than a single one?", "Does the image contain cells where the cytoplasm is interrupted by multiple separate inclusions?"], "properties": ["Does the image show intracellular structures that are generally spherical or ovoid in shape and measure between 0.2 and 2 micrometers in diameter?", "Can you identify cells containing several to dozens of small inclusions within their cytoplasm?", "Are there visible aggregates within cells that appear eosinophilic or basophilic depending on their content?", "Do you see cytoplasmic structures with a higher density than the surrounding cytoplasm?", "Is there evidence of granular or amorphous material distributed in a scattered or clustered pattern throughout the cytoplasm?", "Can you observe intracellular features that are more refractile than the cytosol under light microscopy?", "Are there inclusions within cells that could be composed of proteins, lipids, carbohydrates, or pigments?", "Do you see cytoplasmic features that might contain glycogen, lipid droplets, crystalline proteins, or pigments such as melanin?", "Is there a cell where inclusions occupy anywhere from less than 1% to over 10% of the cytoplasmic volume?", "Can you identify intracellular droplets that suggest a substantial lipid content?", "Are there inclusions that may contain aggregated or crystalline proteins within the cytoplasm?", "Do you see cytoplasmic granules that could represent significant carbohydrate content, such as glycogen?", "Is there evidence of mineral-containing inclusions, such as those with iron or calcium, within the cytoplasm?"], "relational": ["Does the image show cells that contain non-membranous entities within their cytoplasm?", "Can you identify structures within the cytoplasmic compartment that are distinct from membrane-bound organelles?", "Are there visible inclusions in the cytoplasm of cells such as hepatocytes, neurons, macrophages, or adipocytes?", "Does the image display tissues like liver, nervous, or adipose tissue with cells containing multiple inclusions?", "Can you see cytoplasmic features that are found near organelles such as the endoplasmic reticulum, lysosomes, or mitochondria?", "Are there non-membranous structures present within the cell body or cytoplasm?", "Does the image contain cells with inclusions such as glycogen granules, lipid droplets, pigment granules, or crystalline inclusions?", "Can you observe cytoplasmic inclusions in anatomical regions like the liver, brain, adipose tissue, or spleen?", "Are there subcellular structures interacting with inclusions, such as lysosomes, peroxisomes, or microtubules?", "Is there evidence of inclusions located near the cytoskeleton, ribosomes, or Golgi apparatus within the cytoplasm?"], "contexual_behavior": ["Does the image show cells containing more than one distinct structure within their cytoplasm?", "Can you identify any cells that display multiple internal inclusions or bodies?", "Are there visible cytoplasmic features within cells that suggest the presence of several inclusions?"], "functions": ["Does the image show cellular structures that serve as storage sites for materials involved in metabolism or waste management?", "Can you identify features within cells that might be responsible for storing metabolites such as glycogen or lipids?", "Are there visible inclusions that could correspond to pigment granules or lipid droplets?", "Does the image contain evidence of structures that participate in detoxification by isolating harmful substances or metabolic byproducts?", "Can you see any cellular components that might be involved in accumulating or compartmentalizing waste products or indigestible materials?", "Are there features suggesting the regulation of nutrient availability through the storage or mobilization of energy reserves like glycogen or lipids?", "Does the image reveal structures that could protect the cell by sequestering toxins or excess metals?", "Can you identify inclusions that might be accumulating energy-rich compounds such as glycogen or triglycerides?", "Are there visible aggregates or bodies that could indicate a cellular response to stress, such as the storage of damaged or misfolded proteins?", "Does the image show specialized cytoplasmic structures that could be involved in protein or lipid storage, such as protein granules or lipid droplets?"]}, "no_questions": {"contexual_properties": ["Is there any deformation or abnormal shape of one side of the nose, possibly resulting from trauma, congenital anomaly, or tumor invasion?", "Is there visible edema or puffiness on one side of the nose, which could be a response to allergy, trauma, or infection?", "Do you observe any pigmentation changes, such as darkening or uneven color, on one side of the nose that might be due to post-inflammatory hyperpigmentation, melasma, or sun exposure?"], "properties": ["Is there a region where the skin pH is likely slightly acidic, between 4.5 and 5.5?", "Can you see an area with a rich capillary network supporting both the skin and mucosa?", "Is there a part of the nose where the melanin concentration is moderate and reflects the overall facial skin tone?"], "relational": ["Can you identify an area adjacent to the left nasal bone or left maxilla?", "Is there a visible structure composed of skin, subcutaneous tissue, cartilage, bone, and mucosa on the left side of the nose?", "Does the image show a region that could receive blood from the facial artery or lateral nasal artery on the left?"], "contexual_behavior": ["Is there a structure that might display impaired olfactory function due to inflammation or blockage from a sinus infection?", "Is there evidence of reduced airflow through a structure that could be affected by mucosal swelling or inflammation?", "Can you see a region that seems to compensate for reduced function on the opposite side, perhaps by increasing airflow or activity?"], "functions": ["Does the image show a region likely involved in mucus production and ciliary clearance toward the pharynx?", "Is there evidence of a vascularized mucosa that could warm incoming air via heat exchange?", "Can you see a location where olfactory epithelium might be present for detecting odor molecules?"]}}, "dcis": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion located within the mammary gland system?", "Is there an abnormality affecting the epithelial layer or basement membrane of breast ducts?", "Can you identify a structure surrounded by a basement membrane and myoepithelial layer?", "Does the image contain a lesion confined to the mammary or lactiferous ducts?", "Is there evidence of a process arising within the ductal epithelium of the breast?", "Can you see a lesion present in the central, peripheral, or subareolar regions of the breast?", "Does the image show clusters of neoplastic epithelial cells within a ductal structure?", "Is there a structure where myoepithelial cells are present around an abnormal proliferation?", "Can you identify an area where an intact basement membrane separates abnormal cells from surrounding stromal tissue?", "Does the image contain a lesion whose boundaries are defined by ductal walls or a basement membrane?", "Is there evidence of a process confined to ductal structures without involving the lobules of the breast?"], "contexual_behavior": [], "functions": ["Does the image show evidence of epithelial cell proliferation confined within a ductal structure?", "Can you identify a region where the ductal lumen appears obstructed or filled with abnormal cells?", "Is there an area where the organization of epithelial cells within a duct seems disrupted?", "Does the image contain a lesion that remains within the ductal basement membrane without invading surrounding tissue?", "Can you see features suggestive of a non-invasive growth pattern within the breast ducts?", "Is there a region where increased cellular density is visible inside a ductal structure?", "Does the image show signs of local inflammation or immune cell recruitment near a ductal lesion?", "Can you identify areas where the extracellular matrix around a duct appears altered but the basement membrane remains intact?", "Is there evidence of increased mitotic activity or abnormal cell division within a ductal region?", "Does the image reveal loss of cell polarity or abnormal arrangement of epithelial cells within a duct?", "Can you see indications of impaired apoptosis, such as accumulation of abnormal cells within a duct?", "Is there a ductal lesion that could represent an early, non-invasive stage of breast tumorigenesis?", "Does the image contain a structure that could serve as a precursor to invasive breast cancer?", "Can you identify a ductal area where stromal-epithelial interactions appear altered?", "Is there evidence of abnormal signaling or loss of growth control within a ductal epithelial population?", "Does the image show a ductal lesion with an intact basement membrane and no signs of invasion into adjacent tissue?"]}, "no_questions": {"contexual_properties": ["Does the image reveal textural changes such as fibrosis, scarring, or cystic transformation?", "Is there a structure in the image that appears enlarged, which could be associated with conditions like hydronephrosis or acute inflammation?", "Is there evidence of stones or mineral deposits within a tubular or bean-shaped organ, as seen in nephrolithiasis?"], "properties": ["Can you identify a structure that is expected to contain specialized cells such as podocytes or tubular epithelial cells?", "Is there an object whose estimated volume could be between 110 and 190 milliliters?", "Does the image contain an organ with a calcium concentration of 1 to 2 millimoles per kilogram wet weight?"], "relational": ["Can you identify an organ located in the retroperitoneal space of the posterior abdomen?", "Is there a structure situated near the adrenal gland, spleen, or liver?", "Does the image contain an organ that receives blood supply from a vessel known as the renal artery?"], "contexual_behavior": ["Can you identify an object that shows impaired acid-base regulation during chronic disease?", "Can you see a structure that alters electrolyte balance in response to acidosis by increasing hydrogen ion excretion?", "Is there a structure that reduces its function during acute tubular necrosis or glomerulonephritis?"], "functions": ["Can you identify an object that helps control blood pressure through blood volume regulation and renin secretion?", "Can you identify a structure that filters and excretes xenobiotics and metabolic waste from the bloodstream?", "Does the image show an organ where urine is formed through filtration, reabsorption, secretion, and concentration?"]}}}
[ { "answer": "potters facies", "extracted_concepts": [ "potters facies" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "potters facies" ], "question": "is potters facies present?" }, { "answer": "no", "extracted_concepts": [], "question": "is digits present?" }, { "answer": "potters facies", "extracted_concepts": [ "potters facies" ], "question": "what is present?" } ]	["potters facies"]	{"potters facies": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a face with a flattened and broad nasal bridge?", "Can you identify a small and receding chin in the image?", "Is there evidence of widely spaced eyes or increased distance between the eyes?", "Does the face appear to have flat cheeks or poorly defined cheekbones?", "Are the ears positioned lower than usual or do they appear abnormally shaped?", "Is the mouth downturned or does it have a small oral opening?", "Can you observe loose or wrinkled skin, especially around the face?", "Does the skin color appear normal or is there any sign of pallor?", "Are prominent epicanthal folds visible near the eyes?", "Is there a marked degree of micrognathia present?", "Do the lips appear thin or pursed?", "Are multiple facial features flattened or lacking normal contour?"], "relational": ["Does the image show facial features such as a flattened nasal bridge or recessed chin?", "Can you identify low-set ears or epicanthal folds in the facial structures present?", "Is there evidence of abnormalities in the midface, periorbital region, or mandibular area?", "Are there visible alterations in the skin, subcutaneous tissue, or cartilage of the face?", "Does the image reveal skeletal changes involving the mandible, maxilla, or nasal bones?", "Can you observe features that might suggest an association with conditions like Potter sequence or bilateral absence of kidneys?", "Is there any indication of developmental issues such as oligohydramnios reflected in the facial appearance?", "Are there signs of anomalies in the craniofacial system that could be linked to the urinary system?", "Does the image show other congenital anomalies such as limb deformities, underdeveloped lungs, or clubfoot?"], "contexual_behavior": ["Does the image show facial features that could be associated with prolonged or severe deficiency of amniotic fluid during gestation?", "Are there signs of facial changes that might be less pronounced if some renal function and amniotic fluid volume were preserved?", "Can you identify a face that appears unaffected, possibly indicating that any reduction in amniotic fluid was only temporary and resolved before critical development periods?", "Is there evidence of facial characteristics that could be modified or overlapped due to the presence of another craniofacial syndrome?", "Does the image suggest more severe facial alterations that might result from early-onset absence of kidney development and extended periods of low amniotic fluid?", "Are there facial features that appear less distinct, potentially indicating that amniotic fluid levels normalized before mid-gestation?", "Can you see facial variations that might be explained by amniotic fluid loss from causes other than kidney problems, such as chronic leakage?", "Does the image lack the typical facial changes expected when urinary tract obstruction is mild and amniotic fluid remains sufficient?", "Are there visual signs of severe facial flattening that could be linked to impaired airway passages?", "Is there evidence of malformations around the mouth or nose that might contribute to feeding or breathing difficulties in a newborn?"], "functions": ["Does the image show a newborn with facial features that could compromise breathing or cause airway obstruction?", "Is there evidence of facial structure that might interfere with feeding or sucking ability in an infant?", "Can you identify features that suggest an increased risk of aspiration due to altered protective facial anatomy?", "Does the image reveal signs of limited facial muscle function, such as reduced mobility or weakness?", "Is there any indication of oral or facial malformations that could delay or impair speech development?", "Do you observe eyelid abnormalities or reduced facial tone that might hinder effective blinking or eye protection?", "Is there visual evidence of poor oral competence, such as drooling or difficulty controlling saliva?", "Does the facial appearance suggest diminished ability to express emotions or reduced facial expressivity?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of abnormal tissue in organs such as the lung, colon, breast, pancreas, prostate, or stomach?", "Can you see a lesion situated in the thoracic cavity, abdominal cavity, or pelvic region?", "Is there a mass adjacent to parenchyma, connective tissue, or blood vessels?"], "contexual_behavior": [], "functions": ["Can you identify regions where fibroblast activation or increased matrix metalloproteinase activity might be occurring?", "Is there a structure that could be resisting programmed cell death, as suggested by persistent abnormal cell clusters?", "Does the image show signs of sustained mitogenic signaling, such as continuous abnormal cell growth?"]}}}
[ { "answer": "yes", "extracted_concepts": [], "question": "does this image show bilateral?" }, { "answer": "no", "extracted_concepts": [ "peritoneum", "bilateral" ], "question": "does peritoneum show bilateral?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "beckwith-wiedemann syndrome" ], "question": "is beckwith-wiedemann syndrome present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "basilar skull fracture" ], "question": "is basilar skull fracture present?" }, { "answer": "no", "extracted_concepts": [ "tumor" ], "question": "is tumor present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "basilar skull fracture", "extracted_concepts": [ "basilar skull fracture" ], "question": "what is present?" } ]	["beckwith-wiedemann syndrome", "tumor", "bone", "bilateral", "calvarium", "peritoneum", "basilar skull fracture"]	{"beckwith-wiedemann syndrome": {"yes_questions": {"contexual_properties": ["Is there evidence of organ enlargement that could have developed before or shortly after birth?", "Does the image show signs of increased birth weight or fetal overgrowth?", "Can you identify asymmetric limb growth that might be present from birth or early childhood?", "Is there an enlarged tongue visible, particularly in a newborn or infant?", "Does the image reveal any abdominal wall defects, such as omphalocele or umbilical hernia, that are apparent at birth?", "Are there indications of low blood glucose, especially in a neonate?", "Can you see signs of kidney enlargement that may be present prenatally or in early childhood?", "Is there any facial appearance suggestive of midface hypoplasia or prominent eyes in an infant?", "Does the image suggest a predisposition to embryonal tumors, especially in a child?", "Are there visible changes in organ structure, such as altered tissue architecture or cellular overgrowth, in early development?", "Can you detect abnormal ear creases or pits, such as posterior helical pits, present at birth?", "Is there evidence of accelerated somatic growth, particularly in the prenatal or early postnatal period?", "Does the image suggest increased amniotic fluid volume, which might be detected during pregnancy?", "Can you see signs of an enlarged placenta during pregnancy?", "Are there indications of abnormal tissue composition, such as increased mesenchymal tissue or organ hyperplasia, in early life?"], "properties": ["Does the image show an individual with features such as excessive body size or rapid linear growth during infancy?", "Is there evidence of a tongue that appears unusually large compared to the oral cavity?", "Can you identify any organs that appear enlarged relative to typical pediatric anatomy?", "Is there asymmetry in limb or body size suggestive of hemihyperplasia?", "Does the abdominal region display signs of wall defects, such as an omphalocele or umbilical hernia?", "Is the birth weight or overall size of the infant above the 90th percentile for age and sex?", "Does the head circumference appear disproportionately large, possibly exceeding the 90th percentile?", "Are there facial features such as midface hypoplasia, prominent eyes, or visible ear creases or pits?", "Can you observe any signs of nephromegaly, such as visibly enlarged kidneys?", "Is there evidence of tall stature in the child, with height above the 90th percentile for age?", "Does the image suggest the presence of tumors such as Wilms tumor or hepatoblastoma?", "Are there visual indications of neonatal hypoglycemia, such as lethargy or abnormal feeding behavior?", "Can you see any laboratory findings or annotations indicating elevated insulin levels or abnormal methylation at the 11p15 region?", "Is there an umbilical hernia or omphalocele present in the abdominal area?", "Are there any visible signs of organomegaly affecting multiple organs?", "Does the image show a child with features that typically present at birth or in the neonatal period?", "Are there ear creases or pits visible on the external ear in the image?", "Is there evidence of both macroglossia and organomegaly in the same individual?"], "relational": ["Does the image show evidence of overgrowth in soft tissue, muscle, or connective tissue?", "Can you identify any asymmetry in the limbs or face suggestive of hemihyperplasia?", "Is there visible enlargement of the tongue or other features consistent with macroglossia?", "Does the image reveal abnormalities in the abdominal wall, such as incomplete closure or omphalocele?", "Are there signs of visceromegaly, such as an enlarged abdomen or prominent abdominal organs?", "Can you see any features indicating enlargement of the kidneys, liver, or limbs?", "Is there evidence of structural changes in the ear, such as creases or pits?", "Does the image suggest increased size or abnormal appearance of the pancreas or adrenal glands?", "Are there visual cues of altered tissue growth regulation in the musculoskeletal or lymphatic systems?", "Can you observe any changes in embryonic-derived structures, such as the abdominal wall or somatic tissues?", "Is there any indication of tumor risk in abdominal organs like the kidneys or liver?", "Does the image show involvement of multiple organ systems, such as endocrine, digestive, or genitourinary systems?", "Are there visible changes in the face, abdomen, or limbs that could be associated with a congenital overgrowth syndrome?"], "contexual_behavior": ["Does the image show evidence of abnormal growth regulation during fetal development or early childhood, possibly due to disruptions in imprinted gene expression?", "Is there a visible indication of increased risk for embryonal tumors, such as Wilms tumor or hepatoblastoma, particularly in a child?", "Can you identify features suggestive of metabolic dysfunction in infancy, such as signs of hypoglycemia or pancreatic islet cell hyperplasia?", "Does the image display signs of persistent hypoglycemia or disrupted glucose homeostasis during the neonatal period or early infancy?", "Is there evidence of organ overgrowth affecting the liver, kidneys, or tongue during prenatal development or early childhood?", "Can you see indications of abnormal hormone secretion in infancy or childhood, such as increased insulin production or pancreatic beta-cell hyperplasia?", "Does the image suggest postprandial hypoglycemia or impaired blood sugar regulation after feeding in a newborn?", "Is there any sign of susceptibility to hypoglycemia during fasting in a newborn or infant, possibly due to dysregulated insulin secretion?", "Can you identify features that might indicate metabolic instability or increased risk of hypoglycemia in response to surgical stress at any age?", "Does the image show structural anomalies such as nephromegaly or adrenal cytomegaly, suggesting altered kidney or adrenal gland function during childhood?", "Is there any evidence of secondary effects on the immune system during early development, even if immune dysfunction is not the primary feature?", "Can you observe signs of altered growth factor response, such as changes in IGF2 expression, affecting development?", "Does the image reveal abnormal placental function during pregnancy, such as placentomegaly or related complications?", "Is there any indication of impaired wound healing or tissue regeneration in a child, possibly due to altered cellular proliferation or growth factor signaling?", "Can you see signs of increased metabolic rate or anabolic activity during childhood, potentially associated with organ overgrowth?", "Does the image suggest impaired regulation of cell proliferation during embryonic or early postnatal development, possibly due to loss of imprinting at growth-regulating loci?", "Is there evidence of altered defense against oxidative stress during early life, even if this is not a primary clinical feature?", "Can you identify features of hepatomegaly or metabolic disturbances affecting liver function during neonatal development?", "Does the image show generalized or organ-specific overgrowth in infancy or childhood, indicating increased anabolic activity?", "Is there any indication of reduced effectiveness of normal growth suppression mechanisms throughout development, possibly due to epigenetic alterations affecting growth-regulatory genes?"], "functions": ["Does the image show evidence of generalized overgrowth or organ enlargement?", "Can you identify any signs of abnormal growth regulation, such as excessive prenatal or postnatal size?", "Is there visual evidence of metabolic imbalance, such as features suggestive of neonatal hypoglycemia?", "Does the image display enlargement of specific organs, such as the tongue, kidneys, or liver?", "Can you see any indications of abnormal insulin secretion or altered growth factor signaling?", "Is there evidence of increased cellular proliferation or abnormal tissue growth?", "Does the image suggest a predisposition to embryonal tumors, such as Wilms tumor or hepatoblastoma?", "Are there features consistent with glucose dysregulation, particularly in a neonatal context?", "Can you observe abnormal growth patterns or asymmetry in organ development?", "Is there visual evidence of altered sensitivity to growth signals, possibly due to changes in growth factor pathways?"]}, "no_questions": {"contexual_properties": ["Does the image show redness or warmth that could be associated with acute mastitis or inflammatory breast cancer?", "Are there noticeable changes in texture, such as edema, fibrosis, or involvement of the skin by a tumor?", "Is there any ulceration present that could result from a malignant tumor invading the skin or a severe infection?"], "properties": ["Are there features that might be associated with genetic alterations in BRCA1, BRCA2, TP53, or PIK3CA?", "Can you observe any changes that might have developed over several weeks to months?", "Does the image reveal a mass or lesion measuring between 1 millimeter and 5 centimeters?"], "relational": ["Can you identify alterations in glandular, adipose, or connective tissue within the depicted region?", "Does the image reveal any changes in the lactiferous ducts, terminal duct lobular units, or major lobules?", "Does the image display any involvement of the breast, axilla, or chest wall?"], "contexual_behavior": ["Does the image show changes in metabolic activity of breast cells, such as areas of altered density that might indicate neoplastic transformation or inflammation?", "Can you see signs of disrupted signaling between breast cells, such as irregular tissue patterns that might result from mutations or tumor growth?", "Does the image display signs of increased inflammatory activity in the breast, such as swelling or redness that could indicate infection or chronic inflammation?"], "functions": ["Does the structure in question show signs of compromised barrier function, such as increased risk of infection or tissue damage?", "Can you identify any signs of decreased milk production or obstruction of glandular ducts in the relevant area?", "Can you see localized redness, warmth, or swelling that might indicate an enhanced inflammatory process?"]}}, "tumor": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure in the image that appears to originate from epithelial, connective, muscle, or nervous tissue?", "Can you identify an abnormal mass within organs such as the lung, liver, breast, colon, brain, or skin?", "Does the image show an unusual growth in anatomical regions like the head and neck, thorax, abdomen, pelvis, or limbs?", "Is there a visible area composed of densely packed neoplastic or stromal cells?", "Can you see a mass that contains immune cells, endothelial cells, or fibroblasts?", "Is there a structure surrounded by an extracellular matrix or a fibrous capsule?", "Does the image show a mass adjacent to normal tissue?", "Are there blood vessels such as arterioles, capillaries, or newly formed neovasculature supplying a suspicious area?", "Can you identify lymphatic vessels or regional lymph nodes associated with an abnormal structure?", "Is there evidence of a mass infiltrating, compressing, or displacing surrounding tissues?", "Does the image show a structure that could impact the nervous, circulatory, lymphatic, or endocrine systems?", "Is there a region where anatomical barriers like the basement membrane, blood-brain barrier, serosal membranes, or organ capsules appear to be invaded or crossed?"], "contexual_behavior": [], "functions": ["Does the image show a region where cell growth appears uncontrolled or excessive compared to surrounding tissue?", "Can you identify an area that disrupts normal tissue architecture or induces remodeling of the extracellular matrix?", "Is there evidence of a structure interfering with normal cell signaling or blocking differentiation processes?", "Does the image contain a region that might be inhibiting programmed cell death?", "Can you see signs of new blood vessel formation, possibly stimulated by angiogenic factors such as VEGF?", "Is there a visible area that could be evading immune detection or modulating immune cell infiltration?", "Does the image suggest altered metabolic activity, such as increased glycolysis or features consistent with the Warburg effect?", "Can you identify a region invading surrounding tissues, possibly through degradation of the basement membrane or extracellular matrix?", "Is there evidence of cells entering blood or lymphatic vessels, suggesting potential for metastatic spread?", "Does the image show features consistent with resistance to cell death, such as increased cell survival in abnormal regions?", "Can you see modifications in the local microenvironment, such as recruitment of stromal cells or changes in extracellular matrix composition?", "Is there evidence of inflammation, such as accumulation of inflammatory cells or release of cytokines and chemokines?", "Does the image suggest activation of oncogenic signaling pathways or inhibition of tumor suppressor mechanisms?", "Can you identify interactions between abnormal cells and surrounding stromal or immune cells, possibly through direct contact or paracrine signaling?", "Is there evidence of increased genetic instability, such as regions with high mutation rates or impaired DNA repair?", "Does the image suggest systemic effects, such as features associated with cachexia or altered organ function due to released factors?"]}, "no_questions": {"contexual_properties": ["Can you identify an area that looks reduced in size, suggesting atrophy, degeneration, or tissue loss?", "Can you see a structure that seems lighter or reduced in mass, which could be due to atrophy, dehydration, or necrosis?", "Is there a structure in the image that appears enlarged, possibly due to growth, inflammation, or tumor formation?"], "properties": ["Can you identify an object whose weight might be in the nanogram or picogram range?", "Is there evidence of an object with a lipid content of approximately 2% to 5%?", "Is there a structure present that appears spherical or ovoid in shape?"], "relational": ["Does the image include any region where connected vessels or ducts are not identifiable due to insufficient context?", "Can you see any organ whose structural relationships are unclear in the absence of precise definition?", "Can you identify any object for which the relationship to secondary structures cannot be described?"], "contexual_behavior": ["Can you identify a cell type that shows increased activity, which might indicate an adaptive response to stress?", "Is there a feature indicating enhanced activity or regeneration during recovery from illness?", "Does the image suggest an organ whose main role may have shifted, potentially in response to hormonal changes?"], "functions": ["Does the image show cells presenting antigens or interacting with immune cells, suggesting involvement in immune responses?", "Does the image show cells or tissues involved in producing or responding to cytokines, hormones, or growth factors?", "Is there evidence of feedback mechanisms or receptor-mediated signaling regulating cellular activity in the tissue?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you see a sample that might have a density around 1.050 to 1.060 g/mL?", "Can you see a specimen with a protein content typically between 6 and 8 g/dL?", "Can you see a sample that would be expected to contain 150,000 to 450,000 platelets per microliter?"], "relational": ["Can you see anatomical features that participate in immunity, fluid balance, or cell production?", "Does the image contain cells like red blood cells, white blood cells, or platelets?", "Are there visible blood vessels, lymph nodes, or the heart in the image?"], "contexual_behavior": [], "functions": ["Does the image display signs of inflammation, like the mobilization of leukocytes or acute phase proteins?", "Does the image show a response to infection or injury, such as activation of leukocytes or the presence of inflammatory mediators?", "Does the image show evidence of a process responsible for transporting oxygen in the body?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a region that could correspond to the fundus, body, isthmus, or cervix?", "Is there an organ located adjacent to the bladder or rectum?", "Does the image show tubular structures connecting to a larger organ at the uterine cornua?"], "contexual_behavior": [], "functions": ["Is there a structure that produces secretory factors to facilitate embryo implantation?", "Is there evidence of rhythmic contractions under the influence of oxytocin to aid in delivery?", "Does the image show a structure that supports embryo implantation or fetal development?"]}}, "peritoneum": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure in the image that appears pale, glistening, and translucent?", "Can you identify a smooth and slippery surface lining within the abdominal cavity?", "Does the image show a layer with a thickness less than 1 millimeter?", "Is there a structure that could have a surface area comparable to 1.7 to 2.0 square meters in adults?", "Can you see a tissue that might weigh between 100 and 150 grams in an adult human?", "Does the image contain a layer likely composed of mesothelial cells?", "Is there a structure that could contain fibroblasts and macrophages?", "Can you identify a region that might contain fluid rich in water, electrolytes, and proteins?", "Is there a visible area that could be associated with a pH between 7.5 and 8.0?", "Does the image show a structure with high water content, over 90% of its composition?", "Can you see a tissue that is moderately elastic, allowing for expansion and movement of abdominal organs?", "Is there a structure that might contain significant amounts of type I and type III collagen fibers?", "Can you identify a layer that is semi-permeable, allowing selective passage of water and solutes?", "Does the image show a tissue with low lipid content, mainly in cell membranes?", "Is there a structure with a density close to that of soft tissue, around 1.03 grams per cubic centimeter?", "Can you see a region that would be at core body temperature, approximately 37 degrees Celsius?", "Does the image show a layer consisting of a single layer of cells overlying thin connective tissue?", "Is there a structure whose protein concentration in its fluid could be between 1 and 2.5 grams per deciliter?", "Can you identify a region where glucose levels in the fluid might be similar to plasma, around 80 to 120 milligrams per deciliter?"], "relational": ["Does the image show a structure that is part of the digestive system and forms a lining within the abdominal cavity?", "Can you identify a membrane that encloses organs such as the stomach, liver, or intestines?", "Is there evidence of a lining that covers both supramesocolic and inframesocolic regions in the abdomen?", "Does the image reveal two distinct layers of a membrane, one lining the abdominal wall and another covering abdominal organs?", "Can you see structures such as the mesentery or omenta situated between two layers of a membrane?", "Is there a serous lining visible within the abdominal cavity?", "Are there organs present that appear to be positioned behind a membranous lining, such as the kidneys or pancreas?", "Does the image show ligaments like the falciform ligament or splenorenal ligament connecting abdominal organs?", "Can you identify anatomical spaces such as the greater sac or rectouterine pouch defined by a membranous structure?", "Is there visual evidence of blood vessels, such as branches of the inferior phrenic or lumbar arteries, supplying a thin abdominal membrane?"], "contexual_behavior": ["Is there evidence of increased permeability in a membrane-like structure that could be associated with inflammation or cytokine activity?", "Does the image suggest a compromised barrier against infection, possibly due to trauma or severe inflammation?", "Can you identify signs of excess fluid accumulation that might result from injury, peritonitis, malignancy, or liver disease?", "Is there a visible reduction in fluid absorption that could be linked to fibrosis or inflammation?", "Does the image show features suggestive of adhesion formation following surgical trauma or repeated inflammation?", "Are there indications of impaired healing in a membranous layer after surgical trauma, infection, or poor blood supply?", "Can you see signs of enhanced immune activity, such as increased cellularity, in response to bacterial infection?", "Is there evidence of reduced lubrication between abdominal organs, possibly due to chronic disease or sclerosis?", "Does the image reveal altered transport properties in a membrane, potentially as a result of peritonitis or inflammation?", "Are there signs that an intra-abdominal infection is not being effectively contained, possibly due to perforation or necrosis?", "Can you observe features consistent with increased cytokine production, such as those seen in sepsis or systemic inflammation?", "Is there evidence of decreased protection or structural disruption in a membrane due to tumor invasion or malignancy?", "Does the image suggest the presence of a semi-permeable membrane facilitating rapid fluid exchange, as in dialysis?", "Are there indications that abdominal organs are less effectively isolated from each other, perhaps due to widespread inflammation or neoplastic infiltration?", "Can you identify signs of increased fibrotic activity, such as thickening or scarring, following repeated inflammation?"], "functions": ["Does the image show a structure that provides a protective lining for abdominal organs?", "Can you identify a feature that supports or suspends abdominal organs, possibly through mesenteries or ligaments?", "Is there evidence of a physical barrier that could help contain infections within the abdominal cavity?", "Does the image reveal a surface or layer that might secrete serous fluid to reduce friction between organs?", "Can you see any indication of fluid balance regulation within the abdominal cavity, such as areas where fluid might be secreted or absorbed?", "Is there a structure that could house immune cells or contribute to cytokine production for pathogen defense?", "Does the image display any signs of adhesions or encapsulated regions that might indicate infection isolation or injury containment?", "Can you identify a scaffold-like feature that could support tissue regeneration or cellular repair?", "Is there a visible structure, such as the greater omentum, that stores fat and serves as an energy reserve or provides insulation?", "Does the image suggest the presence of a layer that helps maintain intra-abdominal pressure or distributes forces evenly within the abdominal cavity?"]}, "no_questions": {"contexual_properties": ["Is there any indication of increased excretion of a nutrient in the context of high intake, kidney disorders, or diuretic use?", "Does the image show evidence of increased concentration of a nutrient following supplementation or high dietary intake?", "Is there evidence of altered nutrient levels that might be related to pregnancy and increased physiological demand?"], "properties": ["Can you see a substance that is stable under physiological conditions but may degrade under extreme heat or acidic/alkaline environments?", "Is there a compound present that decomposes at around 187\u00b0C and does not have a defined boiling point?", "Can you identify a material with a density of approximately 1.2 g/cm\u00b3?"], "relational": ["Does the image show a segment located in the middle lobe of the right lung, specifically in the medial region?", "Can you see a segment that is directly connected to a segmental bronchus and adjacent lung segments?", "Is there a structure in proximity to the pleura or mediastinum within the right lung?"], "contexual_behavior": ["Are there signs of increased detoxification activity, such as during toxin exposure and enhanced biotransformation?", "Does the image show evidence of reduced coenzyme activity in metabolic pathways that could result from deficiency or impaired absorption?", "Are there indications of increased utilization of metabolic resources during periods of rapid growth?"], "functions": ["Does the image show evidence of a process or structure involved in coenzyme A synthesis?", "Does the image contain indications of fatty acid synthesis or oxidation processes?", "Does the image show any features associated with hormone synthesis, particularly steroidogenesis in the adrenal glands?"]}}, "basilar skull fracture": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a fracture involving the base of the skull, particularly in bones such as the temporal, occipital, sphenoid, or ethmoid?", "Can you identify a break at the skull base that measures from a few millimeters to several centimeters in length?", "Is there a fracture line at the cranial base that appears less than a few millimeters wide?", "Does the image reveal a break limited to the thickness of the cranial base bones, typically only a few millimeters deep?", "Can you see a linear, comminuted, or depressed fracture pattern at the base of the skull?", "Is there a lucent line traversing the base of the skull visible on the image?", "Does the image show an air-fluid level or evidence of pneumocephalus near the base of the skull?", "Can you identify any signs of cerebrospinal fluid leakage in association with a skull base fracture?", "Is there evidence of a fracture at the skull base in a patient who appears to be a young adult?", "Does the image suggest a unilateral fracture at the base of the skull, rather than a bilateral one?", "Is the temporal bone involved in the observed skull base fracture?", "Can you estimate whether the displacement of the fracture at the skull base is minimal, less than 2 millimeters?", "Does the image suggest a healing process at the skull base that might take between 3 and 6 weeks?", "Are there air-fluid levels present near the base of the skull, as seen in about 20% to 30% of such fractures?", "On CT imaging, is there a hypodense (lucent) line at the base of the skull relative to the surrounding bone?", "Can you observe bruising patterns such as blue or purple discoloration behind the ear or around the eyes, which may change to yellow-green as they resolve?"], "relational": ["Does the image show evidence of disruption in bones such as the occipital, temporal, sphenoid, or ethmoid?", "Can you identify abnormalities in the anterior, middle, or posterior cranial fossae?", "Is there any indication of injury near the course of cranial nerves like the olfactory, optic, or facial nerves?", "Does the image reveal changes involving foramina such as the foramen magnum or cribriform plate?", "Are there visible alterations adjacent to the inner ear, nasal cavity, or orbit?", "Can you see involvement of vascular structures like the internal carotid or vertebral arteries?", "Is there evidence of communication between the cranial cavity and spaces such as the subarachnoid space or paranasal sinuses?", "Does the image suggest compromise of membranes like the dura mater or arachnoid mater?", "Are there signs of disruption in sinuses such as the sphenoid or ethmoid sinus?", "Can you identify exposure or compromise of anatomical pathways like cerebrospinal fluid pathways or the auditory canal?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a disruption in the structural integrity of the skull base that could compromise brain protection?", "Is there a visible abnormality that might allow cerebrospinal fluid to leak into the nasal or ear cavities?", "Can you identify features suggesting a breach between the nasal cavity and cranial cavity, such as a defect in the cribriform plate?", "Does the image reveal any signs that could explain cranial nerve deficits, such as those affecting facial movement, hearing, vision, or swallowing?", "Is there evidence of injury to vascular structures at the skull base, such as an epidural hematoma or carotid artery involvement?", "Can you see any indications that might increase the risk of infection entering the central nervous system, such as a direct pathway for pathogens?", "Does the image suggest damage to the auditory or vestibular apparatus that could result in hearing loss, tinnitus, vertigo, or balance disturbance?", "Are there features present that could facilitate the development of a cerebrospinal fluid leak due to openings in the dura mater or bone?", "Is there any sign of functional impairment, such as altered consciousness, seizures, or focal neurological deficits, that could be explained by a structural abnormality at the skull base?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image include cells that might contain enzymes such as myeloperoxidase or elastase?", "Can you identify cells that typically have a lifespan of only a few hours in the bloodstream?", "Does the image show any round cells with a nucleus divided into multiple connected lobes?"], "relational": ["Are there cells that might be found alongside monocytes, eosinophils, or basophils?", "Does the image include structures produced in the bone marrow?", "Is there evidence of cells located within inflamed or infected tissue?"], "contexual_behavior": [], "functions": ["Does the image contain cells that perform phagocytosis and lysosomal degradation of pathogens or debris?", "Can you identify cells that interact with other immune cells by modulating immune responses?", "Is there evidence of rapid accumulation of cells at a site of bacterial infection?"]}}}
[ { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "no", "extracted_concepts": [ "vessel" ], "question": "is vessel present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bilateral cleft palate" ], "question": "is bilateral cleft palate present?" }, { "answer": "no", "extracted_concepts": [], "question": "is silver present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "bilateral cleft palate", "extracted_concepts": [ "bilateral cleft palate" ], "question": "what is present?" } ]	["bilateral cleft palate", "vessel", "face"]	{"bilateral cleft palate": {"yes_questions": {"contexual_properties": ["Does the image show a palatal gap that appears wider than usual, possibly indicating a pre-surgical or growing state?", "Can you observe a deepened separation in the palate that might result from vertical growth of the maxilla during childhood?", "Is there evidence of significant tissue deficiency in the palatal region, suggesting a preoperative or delayed repair condition?", "Do you see abnormal tissue characteristics, such as irregular surfaces, that could be associated with chronic inflammation or infection?", "Is there a palatal defect that appears more pronounced, possibly reflecting a period of rapid craniofacial growth without surgical intervention?", "Can you identify areas of redness or purplish discoloration in the palate, which may indicate infection or inflammation?", "Is there visible scar tissue in the palatal region, suggesting previous surgical repair?", "Do you notice swelling in the palate that could be due to recent surgery or acute infection?", "Is the palatal gap visibly reduced, possibly indicating a successful surgical intervention?", "Can you detect the presence of fluid or exudate in the palatal area, which might be due to infection, inflammation, or fistula formation?", "Are there any ulcerations or open sores in the palate that could result from trauma, infection, or poor oral hygiene?", "Do you see abnormal mucosal texture, such as roughness or irregularity, possibly due to repeated infections, scarring, or failed repairs?", "Is the palatal separation less apparent, potentially reflecting tissue remodeling after surgical repair and aging?", "Can you observe signs of bleeding in the palatal region, which may occur during surgery, trauma, or acute infection?", "Is there a visible fistula or abnormal opening in the palate, possibly indicating a postoperative complication or incomplete healing?"], "properties": ["Is there a structure in the image that shows a gap measuring between 5 and 20 millimeters in width?", "Can you identify a separation extending from the incisive foramen to the uvula, with a length of approximately 20 to 40 millimeters?", "Does the image display a shallow to moderate depression, with a depth between 2 and 8 millimeters, in the palatal region?", "Is there a visible V-shaped or U-shaped gap along the midline of the palate?", "Can you see a midline defect affecting both the hard and soft palate symmetrically?", "Does the image show a structure with a frequency of occurrence in live births between 0.02 and 0.05 percent?", "Is there tissue present that appears pink to reddish, possibly with areas of erythema, in the palatal region?", "Can you identify disrupted mucosa, connective tissue, or exposed bone or cartilage within a palatal gap?", "Does the image reveal a complete separation between the palatal shelves, with no fusion at the midline?", "Is there an area where the palatal tissue thickness is reduced to less than 2 millimeters?", "Can you observe an irregular or uneven surface texture, possibly with ulcerations or granulation tissue, in the palate?", "Is there evidence of bony defects in the palatal region, given that such defects are present in more than 90 percent of similar cases?", "Does the image show involvement of both the hard and soft palate, with the hard palate nearly always affected and the soft palate in most cases?", "Can you see discontinuity or compromised integrity of the mucosa, with exposure of underlying structures in the palate?", "Is the distance between two cleft margins in the palatal region within the range of 5 to 20 millimeters?"], "relational": ["Does the image show a disruption involving both the hard and soft regions forming the roof of the oral cavity?", "Can you identify a gap or separation affecting the midline and lateral aspects of the palatal shelves?", "Is there evidence of interrupted continuity in the maxilla or palatine bones within the oral cavity?", "Does the image reveal separation of the mucosal, muscular, and bony layers of the palate?", "Can you observe a defect indicating failure of fusion between the palatal processes of the maxilla?", "Is there a visible abnormality that could impact muscles such as the levator veli palatini or tensor veli palatini?", "Does the image show a structure adjacent to the nasal septum, upper lip, or lateral nasal wall that appears disrupted?", "Are the anatomical boundaries from the alveolar ridge to the uvula and lateral palatal shelves visibly altered?", "Can you detect additional anomalies such as a cleft in the upper lip, irregular dental development, or nasal deformities?", "Is there an abnormal opening between the oral and nasal cavities that could affect speech or feeding?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a structural defect that could allow food or liquids to pass from the mouth into the nasal cavity, potentially leading to nasal regurgitation?", "Is there a visible abnormal communication between the oral and nasal spaces that might disrupt normal swallowing or oropharyngeal coordination?", "Can you identify a feature that could prevent proper closure of the velopharyngeal port, possibly resulting in hypernasal speech or articulation difficulties?", "Does the image suggest a condition that would make it difficult for an infant to create suction during feeding, potentially leading to poor intake or prolonged feeding times?", "Is there a structural abnormality that could compromise airway protection during eating or drinking, increasing the risk of aspiration or choking?", "Can you see an oronasal fistula or palatal defect that disrupts the normal separation between the oral and nasal cavities?", "Does the image show a feature that might alter nasal airflow or increase the likelihood of airway obstruction, possibly causing breathing difficulties?", "Is there evidence of a defect that could reduce the ability to generate intraoral pressure, affecting effective sucking, swallowing, or speech sound production?", "Can you identify a structural issue that might impair Eustachian tube function, increasing the risk of recurrent ear infections or middle ear effusion?", "Does the image suggest disturbances in facial growth or dental alignment, such as maxillary deficiency or malocclusion?", "Is there any indication that the individual may have developed compensatory mechanisms, such as atypical speech articulation or altered swallowing patterns, to adapt to a structural defect in the palate?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify evidence of a study that visualizes the gastrointestinal tract using X-ray imaging?", "Does the image show features consistent with the administration of a substance to outline the esophagus, stomach, or intestines on an X-ray?", "Is there a visible indication of a process designed to enhance the contrast of internal digestive structures for radiographic examination?"], "relational": ["Are there features indicating assessment of the small or large intestine?", "Is there a visible distinction of the mucosa, submucosa, or muscularis layers within the digestive organs?", "Can you identify structures belonging to the digestive system that appear enhanced in the image?"], "contexual_behavior": ["Does the image depict a diagnostic procedure involving the use of a radiopaque contrast agent?", "Can you identify evidence of a study that visualizes the gastrointestinal tract using imaging techniques?", "Is there a visible indication of a substance enhancing the contrast of internal digestive structures on the image?"], "functions": ["Does the image show enhanced visualization of the gastrointestinal tract using a contrast agent?", "Is it possible to evaluate the shape, movement, or transport function of the esophagus, stomach, or intestines based on the image?", "Does the image allow assessment of swallowing by showing the movement of a substance through the oropharynx or esophagus?"]}}, "vessel": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the cardiovascular or lymphatic system?", "Can you identify any objects that could be classified as arteries, veins, capillaries, or lymphatic vessels?", "Is there a structure composed of endothelium, smooth muscle, or connective tissue visible in the image?", "Does the image contain any objects that connect to organs or other similar tubular structures?", "Can you see a structure that supplies blood or lymph to organs such as the brain, kidneys, liver, lungs, or muscles?", "Is there evidence of a continuous circuit for blood or lymph transport involving the heart?", "Are there tubular structures present in anatomical regions such as the head, neck, thorax, abdomen, or limbs?", "Can you observe any nerves, lymphatic vessels, or ducts running alongside a tubular structure?", "Does the image include subdivisions of tubular structures, such as arterioles or venules?", "Is there a visible interaction between a tubular structure and the nervous, musculoskeletal, or lymphatic systems?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for transporting blood, nutrients, or gases throughout the body?", "Can you identify a network that includes arteries, veins, or capillaries facilitating directional flow?", "Is there evidence of a structure that delivers oxygen and nutrients to tissues via exchange with interstitial fluid?", "Does the image contain a feature involved in removing waste products from tissues and transporting them to excretory organs?", "Can you see a structure that might regulate blood pressure through changes in wall diameter?", "Is there an object that maintains fluid balance by controlling plasma and interstitial fluid movement?", "Does the image show a structure that could contribute to thermoregulation by adjusting blood flow to the skin or extremities?", "Can you identify a pathway that enables immune cells to exit the bloodstream and enter tissues?", "Is there a feature that supports wound healing by supplying nutrients, oxygen, and immune cells to an injury site?", "Does the image show a structure that responds to injury or inflammation through increased permeability or recruitment of immune cells?", "Can you see evidence of a system ensuring adequate tissue perfusion and oxygen delivery?", "Is there a structure that distributes hormones by transporting endocrine signals to target organs?", "Does the image contain a feature that adapts its structure or diameter in response to changes in blood flow demand?", "Can you identify a component that helps prevent blood loss after injury by supporting clot formation or initiating vasoconstriction?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Are there adjacent structures visible, such as eyelids, extraocular muscles, or the lacrimal gland?", "Does the specimen appear to be contained within the ocular system or nervous system?", "Can you observe cellular components like photoreceptors, retinal ganglion cells, endothelial cells, or fibroblasts?"], "contexual_behavior": ["Is there evidence of a structure that would no longer respond to light due to chemical treatment?", "Is there a structure where enzymatic activity might be better preserved if milder chemicals and shorter processing times were used?", "Can you see evidence that synaptic architecture is better preserved in areas likely subjected to rapid chemical processing?"], "functions": ["Does the image allow assessment of structural integrity or changes related to retinal function or retinal diseases?", "Is there evidence of distinct retinal layers or neural circuits involved in vision present in the image?", "Can you see spatial organization or mapping of different cell types and tissue layers in the specimen?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a lesion present in the small intestine, appendix, rectum, or bronchi?", "Does the image reveal a mass adjacent to the muscularis propria, serosa, or mesentery?", "Is there a mass in proximity to mesenteric veins, the portal vein, or submucosal capillaries?"], "contexual_behavior": [], "functions": ["Does the image contain a structure that might impair gastrointestinal motility or be associated with symptoms like diarrhea or abdominal pain?", "Is there a structure that might cause vascular changes such as fibrosis, increased blood vessel formation, or altered local blood flow?", "Is there evidence of a lesion that might be responsible for excessive serotonin or histamine production?"]}}}
[ { "answer": "extensive lesions", "extracted_concepts": [ "extensive lesions" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "extensive lesions" ], "question": "does this image show extensive lesions?" }, { "answer": "no", "extracted_concepts": [ "papillary adenoma", "extensive lesions" ], "question": "does papillary adenoma show extensive lesions?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "no", "extracted_concepts": [ "temporal muscle hemorrhage" ], "question": "is temporal muscle hemorrhage present?" }, { "answer": "herpes zoster", "extracted_concepts": [ "herpes zoster" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "herpes zoster" ], "question": "is herpes zoster present?" }, { "answer": "no", "extracted_concepts": [ "nipples" ], "question": "is nipples present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "herpes zoster", "extracted_concepts": [ "herpes zoster" ], "question": "what is present?" } ]	["herpes zoster", "papillary adenoma", "temporal muscle hemorrhage", "nipples", "face", "extensive lesions"]	{"herpes zoster": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show skin lesions that appear round or oval in shape?", "Can you identify clusters of vesicles measuring between 2 and 5 millimeters in diameter?", "Is there evidence of clear or pale yellow fluid within any skin vesicles?", "Do you observe between 20 and 100 lesions grouped in a localized area?", "Is there a region of skin that appears to have a slightly elevated temperature compared to surrounding tissue?", "Are there vesicles present that contain serous fluid?", "Can you see crust formation on some lesions that may have developed within the past 7 to 10 days?", "Is there a visible area where the skin thickness appears normal or only slightly increased due to inflammation?", "Do any lesions display a vesicular or crusted texture?", "Are there signs that the affected skin area could be associated with moderate to severe pain?", "Does the distribution or appearance of lesions suggest a healing time of approximately 2 to 4 weeks?", "Can you infer the presence of a condition that may lead to persistent pain lasting 1 to 3 months after the skin lesions resolve?", "Is there any indication that the fluid within the vesicles might have a mildly alkaline pH, around 7.4 to 7.6?", "Could the concentration of viral DNA in the lesion fluid be within the range of 10^4 to 10^7 copies per milliliter?"], "relational": ["Does the image show any abnormalities affecting both the skin and the nervous system?", "Can you identify lesions involving the epidermis or dermis?", "Is there evidence of changes in areas innervated by sensory nerves, cranial nerves, or spinal nerves?", "Are there visible skin changes following the pattern of thoracic, trigeminal, or lumbar dermatomes?", "Does the image suggest involvement of regions such as the chest, abdomen, face, neck, or limbs in a pattern consistent with dermatomal distribution?", "Can you see signs that might indicate reactivation of a condition from ganglia associated with sensory or cranial nerves?", "Is there evidence of inflammation or viral spread along peripheral nerves or axonal transport routes?", "Does the image show features that could be explained by processes in the peripheral or central nervous system, particularly involving sensory ganglia?", "Are there visible lesions that might contain keratinocytes, Langerhans cells, inflammatory cells, or viral-infected neurons?"], "contexual_behavior": [], "functions": ["Does the image show evidence of acute inflammation or vesicular eruptions on the skin?", "Can you identify skin lesions that might result from viral migration along sensory nerves?", "Is there any indication of localized epidermal cell lysis or vesicle formation visible?", "Does the image suggest inflammation or swelling in areas corresponding to sensory nerve pathways?", "Can you observe features that might indicate impaired sensory nerve function, such as changes in skin sensation or texture?", "Is there any visual evidence of chronic skin changes that could be associated with persistent nerve injury or sensitization?", "Does the image display signs of neuroinflammation, such as redness or swelling along nerve distributions?", "Can you see any indications of disrupted skin barrier function, like open lesions or areas susceptible to secondary infection?", "Is there evidence of tissue inflammation that could be explained by the release of pro-inflammatory cytokines or immune cell recruitment?", "Does the image show patterns of skin involvement that follow nerve pathways, suggesting anterograde axonal spread to peripheral tissues?", "Can you identify any features that might result from immune suppression or altered antigen presentation in the affected area?", "Is there visual evidence of localized pain or hypersensitivity that could be linked to increased nociceptor excitability?", "Does the image suggest the presence of postherpetic neuralgia, such as chronic skin changes or scarring in a dermatomal distribution?"]}, "no_questions": {"contexual_properties": ["Can you identify an ovarian feature that may represent a temporary endocrine gland with hemorrhagic characteristics?", "Is there a visible ovarian structure that could be involved in the menstrual cycle and shows signs of internal hemorrhage?", "Does the image show a structure within the ovary that appears to contain blood or evidence of recent bleeding?"], "properties": ["Can you see a structure with a thickened wall and internal fibrin strands?", "Can you identify an object with a reddish-brown appearance, possibly due to the presence of blood?", "Does the image reveal an object with a volume that could be estimated between 2 and 10 milliliters?"], "relational": ["Can you identify a structure that develops from an ovarian follicle following ovulation?", "Is there evidence of localized hemorrhage or enlargement within the ovary?", "Can you see blood vessels such as branches of the ovarian artery or surrounding capillaries near a particular structure?"], "contexual_behavior": ["Does the image show an ovarian entity with characteristics of both luteal tissue and blood?", "Is there a visible ovarian structure that appears to have hemorrhagic features?", "Does the image contain a structure that could represent a corpus luteum with evidence of bleeding or blood accumulation?"], "functions": ["Does the image show a temporary ovarian structure involved in hormone secretion?", "Does the image show a structure that prevents endometrial shedding by maintaining the uterine lining through progesterone production?", "Is there evidence of a structure that maintains progesterone levels during early pregnancy to support the uterine lining?"]}}, "papillary adenoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion arising within the urinary system?", "Is there a structure originating from the epithelial lining of renal tubules?", "Can you identify a mass located within the kidney?", "Is there a lesion situated in the renal parenchyma, possibly near the cortex or medulla?", "Does the image contain a small, well-circumscribed structure with papillary or tubular architecture?", "Can you see a mass lined by cuboidal epithelial cells or clear cells?", "Is there evidence of a lesion separated from surrounding tissue by a thin fibrous capsule or compressed stroma?", "Does the image show a structure that may be compressing or displacing adjacent nephrons or small blood vessels?", "Is there a mass associated with renal tubules and peritubular capillaries?", "Can you identify a lesion with bland cytology and lacking significant atypia?"], "contexual_behavior": [], "functions": ["Does the image show a benign growth with papillary architecture?", "Is there evidence of a structure that could disrupt normal glandular secretion?", "Can you identify an area where healthy tissue appears compressed or replaced by an abnormal mass?", "Does the image contain a region with increased local cellular proliferation forming papillary projections?", "Is there a structure that might be interfering with tissue organization or potentially obstructing a duct or lumen?", "Can you see an area where epithelial cells are proliferating in a non-invasive but dysregulated manner?", "Does the image reveal a slow-growing mass that lacks signs of invasion into surrounding tissues?", "Is there a lesion exerting a mass effect or causing local compression without infiltrating adjacent structures?", "Can you identify a region where the normal architecture of an organ is distorted, possibly leading to functional impairment or obstruction?", "Does the image display papillary fronds or abnormal arrangements of epithelial cells indicating architectural distortion?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of granulomatous tissue with caseous necrosis?", "Can you see material that appears to be contained by or draining into lymphatic vessels or lymph nodes?", "Does the image show evidence of a pathological process associated with Mycobacterium tuberculosis infection in organs such as the lungs, pleura, or lymph nodes?"], "contexual_behavior": [], "functions": ["Is there visual evidence of cellular debris being cleared, possibly through the activity of enzymes or phagocytic cells?", "Can you identify a matrix-like material that might facilitate immune cell accumulation and the delivery of antimicrobial molecules?", "Does the image suggest alterations in the local tissue microenvironment, such as changes in pH, oxygen levels, or nutrient availability, that could affect host-pathogen interactions?"]}}, "temporal muscle hemorrhage": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an ovoid or lentiform collection within the muscle visible in the image?", "Can you identify a localized area within the temporal muscle or adjacent fascia that appears hyperdense or bright on CT?", "Does the image show a region with a thickness between 0.5 and 2 centimeters?", "Is there a collection measuring between 1 and 4 centimeters in its greatest dimension?", "Can you see a structure whose volume could be estimated as less than 20 milliliters?", "Does the image contain an area with a density between 50 and 80 Hounsfield units on CT?", "Is there a region with variable signal intensity on MRI that could correspond to blood at different stages?", "Can you identify a collection composed of blood, clot, and surrounding edematous muscle tissue?", "Is there a finding that appears limited to the temporal muscle and its fascia without extending to other regions?", "Does the image show a feature that might resolve within 2 to 6 weeks depending on its size and management?"], "relational": ["Is there evidence of abnormal blood accumulation within the temporal region of the head?", "Does the image show changes affecting the musculoskeletal system in the area near the temporalis or masseter muscles?", "Can you identify any disruption or abnormality adjacent to the temporal bone or zygomatic bone?", "Is there a visible alteration involving the deep temporal arteries or superficial temporal artery?", "Does the image reveal changes within skeletal muscle tissue, subcutaneous tissue, or periosteum in the temporal area?", "Is there involvement of fascia, such as the temporal fascia or deep temporal fascia, in the observed abnormality?", "Can you see any abnormality within the temporal fossa or masticator space?", "Is there evidence of risk or involvement of cranial nerves near the temporal region?", "Does the image show any effect on the temporalis muscle or superficial temporal artery?", "Are there visual signs suggesting proximity to the deep temporal nerves or auriculotemporal nerve?"], "contexual_behavior": ["Is there evidence of muscle fiber disruption that could interfere with normal contraction in the temporal region?", "Can you identify signs of local vascular compression or reduced blood supply to muscle fibers near the side of the head?", "Does the image suggest impaired chewing efficiency due to swelling, pain, or dysfunction in the muscles involved in mastication?", "Is there visible inflammation or edema in the temporal area that could indicate an inflammatory response to extravasated blood?", "Can you see a hematoma or other features suggesting restricted oxygen delivery to muscle cells in the temporal region?", "Does the image show signs that muscle regeneration or repair might be impaired due to injury and inflammation?", "Is there evidence of disrupted force transmission or structural abnormalities affecting muscle function near the temple?", "Can you identify features that suggest delayed healing or chronic inflammation in the temporal muscle area?", "Does the image reveal a hematoma or tissue damage that could increase the risk of secondary infection in the temporal region?", "Is there abnormal swelling or edema that might limit jaw movement or reduce the range of motion?", "Can you see indications of metabolic dysfunction in the muscle, such as signs of ischemia or impaired nutrient delivery?", "Does the image suggest chronic muscle dysfunction or unresolved injury following trauma to the temporal area?", "Is there abnormal tissue swelling that could impair muscle function by increasing volume and pressure in the temporal region?", "Can you identify features that might indicate decreased neuromuscular coordination due to pain, inflammation, or structural disruption?", "Does the image suggest that ongoing pain, swelling, or tissue damage could limit the effectiveness of physical therapy in the temporal muscle?"], "functions": ["Does the image show evidence of swelling or edema in a region associated with chewing muscles?", "Can you identify an area where muscle activity might be impaired due to local injury?", "Is there a visible sign that could indicate pain or discomfort in the region responsible for jaw movement?", "Does the image suggest limited jaw mobility or trismus, possibly due to underlying tissue changes?", "Can you observe features that might reflect decreased blood flow or vascular compression in a masticatory muscle?", "Is there any indication of inflammatory cell recruitment or local inflammation in the area near the temporal region?", "Does the image reveal tissue changes that could activate nociceptors or cause local irritation?", "Can you see signs of delayed tissue regeneration or persistent inflammation in a muscle adjacent to the jaw?", "Is there evidence of mechanical obstruction or swelling that could interfere with the function of nearby tissues?", "Does the image suggest weakness or dysfunction in a muscle involved in mastication, potentially leading to painful chewing?", "Can you identify features that might indicate impaired clearance of cellular debris or prolonged inflammation in a muscle near the temporal bone?"]}, "no_questions": {"contexual_properties": ["Can you see signs of infection or inflammation that might be associated with increased metabolic turnover and decreased nutrient levels?", "Is there any indication of decreased nutrient levels in association with kidney disease or renal dysfunction?", "Can you identify features of chronic inflammatory conditions that might cause decreased nutrient levels due to increased demand or altered metabolism?"], "properties": ["Can you identify a compound with a molecular weight close to 169.18 g/mol?", "Does the image show a molecule that could exist in forms such as pyridoxal 5'-phosphate, pyridoxine, or pyridoxamine?", "Does the image contain a molecule featuring a pyridine ring with functional groups characteristic of pyridoxine, pyridoxal, or pyridoxamine?"], "relational": ["Does the image show vessels such as a segmental pulmonary artery, segmental pulmonary vein, or lymphatic vessels within a lung segment?", "Can you see a region that maintains anatomical relationships with the heart and pleura through its position in the lung?", "Is there a structure that interacts with both the circulatory and lymphatic systems within the lung?"], "contexual_behavior": ["Are there visual signs of increased neurotransmitter production during inflammation, possibly due to upregulated synthesis pathways?", "Does the image depict a scenario such as pregnancy or lactation where metabolic requirements for certain nutrients are heightened?", "Can you identify features of impaired red blood cell formation that might result from malabsorption syndromes affecting intestinal uptake of a key nutrient?"], "functions": ["Is there visual evidence of energy metabolism processes like glycogenolysis or gluconeogenesis?", "Can you see any cellular activity that might be associated with nucleic acid synthesis, such as one-carbon metabolism or the folate cycle?", "Does the image show evidence of a process that requires an enzyme cofactor for amino acid metabolism, such as transamination or decarboxylation?"]}}, "nipples": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure present that measures approximately 1 to 2 centimeters in diameter and projects about 0.5 to 1 centimeter from the surface?", "Can you identify an area with a color ranging from pink to dark brown, possibly darker than the surrounding skin?", "Does the image show a region with a cylindrical or conical shape?", "Is there a surface that appears slightly rough or wrinkled, possibly due to small papillae and multiple openings?", "Can you see a structure that might contain between 4 and 18 small openings on its surface?", "Is there an area that could be composed of cell types such as keratinocytes, melanocytes, myoepithelial cells, or ductal epithelial cells?", "Does the image include a region that likely has high sensitivity due to dense innervation?", "Can you identify a structure with a uniform or slightly mottled pigmentation pattern?", "Is there a part of the image that might have a water content similar to other skin tissues, around 60 to 70 percent?", "Does the image show a region with relatively low fat content compared to the surrounding tissue?", "Is there a structure whose tissue density appears similar to other soft tissues, approximately 1.05 grams per cubic centimeter?", "Can you identify an area that would be expected to have a mildly acidic pH, between 4.5 and 5.5?", "Is there a structure that could exhibit moderate elasticity, allowing for stretching and recoil?"], "relational": ["Is there a structure present that belongs to both the integumentary and reproductive systems?", "Can you identify an anatomical feature centrally located within a pigmented circular area?", "Does the image show a structure adjacent to the areola or mammary glands?", "Is there an object positioned on the anterior thoracic region of the body?", "Can you see a structure that serves as the external outlet for milk secretion?", "Is there a visible feature where lactiferous ducts might terminate and open?", "Does the image contain a structure composed of stratified squamous epithelium and smooth muscle?", "Can you identify an area supplied by branches of the internal thoracic or lateral thoracic arteries?", "Is there a structure likely innervated by the fourth intercostal nerve?", "Can you see a region where the skin includes epidermis, dermis, and subcutaneous tissue?", "Is there an object that is centrally positioned within a pigmented area on the chest?"], "contexual_behavior": [], "functions": ["Does the image show a structure that facilitates milk delivery?", "Can you identify an area that provides an accessible point for infant latch during breastfeeding?", "Is there a visible conduit for milk to pass from lactiferous ducts to an infant?", "Does the image contain a structure that could respond to hormonal changes such as increased prolactin or oxytocin?", "Can you see a region likely to contain dense sensory nerve endings for detecting touch or temperature?", "Is there a part of the image that could transmit tactile stimulation to trigger the let-down reflex?", "Does the image show a structure capable of regulating milk flow through smooth muscle contraction in response to suckling?", "Can you identify an area that provides tactile or olfactory cues important for infant feeding behavior?", "Is there a visible structure that might change shape or sensitivity in response to temperature?", "Does the image include a region involved in transmitting sensory signals that contribute to sexual arousal?"]}, "no_questions": {"contexual_properties": ["Is there abnormal tissue growth in a tube near the ovary, which could be due to endometriosis or neoplastic transformation?", "Can you observe cystic changes in a tube adherent to the ovary, as seen in hydrosalpinx or chronic salpingitis?", "Is there evidence of fibrous tissue formation in a tube adherent to the ovary, possibly resulting from chronic inflammation and healing?"], "properties": ["Is there a structure where fibrosis appears minimal under normal conditions?", "Can you identify an object whose tissue pH would be near neutral, around 7.2 to 7.4?", "Can you see an object with high water content, approximately 70% by weight?"], "relational": ["Is there a structure in the reproductive tract that communicates with the uterus at the uterine horn?", "Is there evidence of adhesion or physical attachment between a tubular structure and an ovary?", "Does the image contain a structure that is supported by tissues such as the mesosalpinx or serosal layers?"], "contexual_behavior": ["Does the image show a tubular structure with signs of impaired peristaltic activity, possibly due to infection affecting smooth muscle contractility?", "Does the image show a tube that may fail to support embryo transport due to mechanical obstruction or loss of coordinated motility from pelvic adhesions?", "Does the image contain a tubular structure that appears unable to clear debris or pathogens effectively, indicating chronic infection or impaired mucociliary clearance?"], "functions": ["Does the image show a location where sperm and egg could meet, but where adhesion might disrupt this process?", "Can you see any indication of mechanical obstruction or altered function in a tube that could lead to infertility?", "Can you observe restricted movement of fimbriae or impaired access to the ovary, possibly interfering with ovum capture?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you determine if the image has a high number of pixels per unit area, indicating fine detail?", "Is it possible to deduce the number of bits used for each pixel based on the image's color richness or grayscale levels?", "Does the vertical dimension of the image appear to match common values like 768 or 1536 pixels?"], "relational": ["Does the image display structures that could be cells or tissues?", "Is there any indication that the visualized material comes from a histological section or tissue slice?", "Can you see cellular components such as nuclei or cytoplasm?"], "contexual_behavior": ["Can you see chromatin condensation or other changes that might obscure mitotic structures in treated samples?", "Are there morphological changes in cells that could be attributed to infection, such as swelling, infiltration, or inclusion bodies?", "Are there regions where specific staining techniques have enhanced contrast or highlighted particular cellular components?"], "functions": ["Does the image display pathological features that could influence therapeutic decisions, such as tumor grade or infection type?", "Does the image allow for the visualization of cellular processes such as cell division or signaling at high resolution?", "Is there evidence in the image that could be used to monitor changes in tissue or cellular characteristics over time?"]}}, "extensive lesions": {"yes_questions": {"contexual_properties": ["Does the image show any areas that appear to have increased in size, suggesting active disease progression or ongoing tissue damage?", "Can you identify regions that have decreased in size, possibly indicating effective treatment or natural healing?", "Are there more affected areas present, which could suggest the underlying pathology has spread to new sites?", "Do any regions display a change in color that might be due to altered blood flow, inflammation, or necrosis?", "Is there evidence of deeper involvement in any affected areas, suggesting tissue destruction extending into underlying layers?", "Can you see raised regions that might result from edema, increased cellular proliferation, or exudate accumulation?", "Are there open sores or areas where the surface tissue appears to have broken down, indicating ulceration?", "Do any regions show signs of increased inflammation, such as redness or swelling, consistent with an acute immune response or infection?", "Is there evidence of tissue death, such as darkened or necrotic areas, possibly due to compromised blood supply or severe injury?", "Can you identify borders that appear irregular or abnormal, which could suggest malignant transformation or irregular growth?", "Are there areas with increased fluid or exudate, possibly indicating active inflammation or infection?", "Do any regions appear fibrotic or scarred, suggesting chronic healing or scarring processes?", "Is there a noticeable change in texture, such as hardening or softening, that could result from edema, fibrosis, or necrosis?", "Are there areas that might be more painful to touch, potentially due to exposed nerve endings or intensified inflammation?", "Can you see evidence of increased cellular infiltration, such as dense or opaque regions, indicating an active immune or inflammatory response?", "Are there signs of bleeding within any affected areas, suggesting vascular damage or hemorrhage?", "Do any regions appear to be infected, as indicated by pus, swelling, or other signs of microbial colonization?", "Is there evidence of abnormal tissue composition, such as the presence of atypical cells or changes in the extracellular matrix?", "Are there hardened regions that could be due to fibrosis, calcification, or chronic inflammation?", "Do any areas show increased swelling or edema, possibly resulting from acute inflammation or vascular leakage?"], "properties": ["Is there an area in the image that exceeds 5 cm in diameter or involves a large anatomical region?", "Can you identify a region with an irregular or poorly defined shape?", "Does the image show an area with coloration that appears red, purple, or pale?", "Is there a region that appears to extend from the surface into deeper tissues, possibly beyond the dermis?", "Can you see an area with a heterogeneous texture, such as roughness, firmness, or ulceration?", "Is there a region affecting a surface area greater than 10 cm\u00b2 or involving multiple contiguous regions?", "Does the image contain a region with indistinct, irregular, or poorly demarcated borders?", "Can you identify an area whose consistency appears variable, ranging from soft to firm?", "Is there a region that seems to contain a mixture of necrotic tissue, inflammatory cells, and viable tissue?", "Does the image show an area with fluid content that could be serous, purulent, or hemorrhagic?", "Is there a region that appears warmer than the surrounding tissue, suggesting elevated temperature?", "Can you identify an area where the pH might be slightly acidic to neutral, typically between 5.5 and 7.0?", "Does the image suggest the presence of inflammatory cells such as neutrophils, macrophages, or lymphocytes within a region?", "Is there evidence of increased vascularity, such as prominent neovascularization or dilated blood vessels, in any area?", "Can you see a region where tissue density appears variable, possibly decreased in necrotic zones and increased in fibrotic or indurated areas?"], "relational": ["Does the image show an area where both epithelial and connective tissues appear affected?", "Can you identify a region involving multiple tissue types such as muscle or nervous tissue?", "Is there evidence of widespread abnormality in organs like the skin, liver, or lungs?", "Does the image display changes in the abdominal or thoracic regions that could indicate significant tissue involvement?", "Can you see any affected areas in the limbs or cranial region?", "Are there visible disruptions near blood vessels or nerves adjacent to an abnormal region?", "Does the image show involvement of structures like lymphatic vessels or surrounding organs next to a damaged area?", "Is there a region that could impact the integumentary or musculoskeletal systems?", "Can you identify an area that might affect the nervous or digestive systems?", "Are there visible accumulations of inflammatory or necrotic cells within a large abnormal region?", "Does the image show fibroblasts or epithelial cells within a disrupted tissue area?", "Is there a visible boundary between damaged and healthy tissue, suggesting loss of function or inflammation?", "Can you see evidence of tissue remodeling at the interface of a large abnormal region?", "Does the extent of the abnormality appear to follow anatomical boundaries such as fascial planes or organ capsules?", "Is there involvement of tissue layers like the epidermis, dermis, or subcutaneous tissue in a widespread area?", "Can you identify disruption in muscle layers or mucosa over a large region?", "Does the abnormal region appear to span compartments such as intracavitary spaces or visceral cavities?"], "contexual_behavior": [], "functions": ["Does the image show areas where tissue integrity appears severely compromised, potentially leading to impaired organ function?", "Is there evidence of disrupted cellular architecture or loss of normal tissue structure that could interfere with physiological signaling?", "Can you identify regions where organ performance might be reduced due to structural or functional compromise?", "Are there visible signs suggesting delayed tissue repair or the presence of chronic wounds?", "Does the image reveal features consistent with excessive inflammation or suppressed local immune activity?", "Is there an area where tissue regeneration seems impaired, possibly due to stem cell loss or disruption of the extracellular matrix?", "Can you observe damage to blood vessels or regions with impaired blood flow that might indicate ischemia?", "Are there indications of barrier breakdown, such as loss of protective tissue layers or increased vulnerability to external factors?", "Does the image display regions where metabolic activity could be compromised, such as areas with reduced cellular viability or impaired nutrient exchange?", "Is there evidence of nerve injury or sensory loss, such as damaged neural pathways or blocked signal transmission?", "Can you see signs of an inflammatory response, such as immune cell infiltration or cytokine release in affected areas?", "Are there features suggesting increased susceptibility to infection, possibly due to compromised tissue barriers or impaired immune surveillance?", "Does the image show functional loss in a vital organ, such as evidence of critical impairment or risk of organ failure?"]}, "no_questions": {"contexual_properties": ["Is there a visible reduction in body fat percentage in two newborns, especially if they appear preterm?", "Do the Apgar scores of two newborns appear to differ, especially in the context of preterm delivery or birth complications?", "Can you observe differences in amniotic fluid volume between two fetuses, which might suggest a complication such as transfusion syndrome?"], "properties": ["Are there two newborns present whose combined birth weights appear lower than that of a typical singleton?", "Are there two newborns with respiratory rates between 30 and 60 breaths per minute?", "Do you observe a pair of newborns with head circumferences between 32 and 34 centimeters?"], "relational": ["Can you observe vascular connections between placental regions, such as arterio-arterial or veno-venous anastomoses?", "Does the image indicate the presence of diamniotic or monoamniotic sacs around the fetuses?", "Is there a visible arrangement suggesting dichorionic or monochorionic placentation?"], "contexual_behavior": ["Does the image show a pair of infants who could be at risk for organ function impairment due to shared circulation, such as in monochorionic gestation or twin-to-twin transfusion syndrome?", "Can you identify two newborns who may have experienced altered hormonal regulation during fetal or early postnatal life?", "Does the image include infants who might be at increased risk for developmental delays due to being born before 37 weeks of gestation?"], "functions": ["Can you identify two individuals who appear to have lower birth weight compared to typical singletons?", "Is there evidence of hormonal signaling or behavioral interaction between two closely positioned newborns?", "Can you distinguish phenotypic variation or differences in traits that might suggest genetic or epigenetic influences between two individuals?"]}}}
[ { "answer": "invasive breast carcinomas", "extracted_concepts": [ "spicular margins", "breast tissue", "dense masses", "mammograms", "invasive breast carcinomas", "invasion of adjacent radiolucent breast tissue", "adjacent radiolucent breast tissue" ], "question": "what appear as dense masses with spicular margins resulting from invasion of adjacent radiolucent breast tissue in mammograms b?" } ]	["spicular margins", "breast tissue", "dense masses", "mammograms", "invasive breast carcinomas", "invasion of adjacent radiolucent breast tissue", "adjacent radiolucent breast tissue"]	{"spicular margins": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a region in the image where fine, radiating lines extend outward from a central lesion?", "Can you identify an area with a star-like or stellate pattern surrounding a mass?", "Does the image show structures with thin projections, each less than 1 millimeter in width?", "Are there radiating features that appear less dense than the central mass?", "Can you see a radiating arrangement of lines at the edge of a lesion?", "Is there an irregular margin characterized by fine lines extending from a central area?", "Does the image contain between 5 and 20 narrow projections radiating from a lesion?", "Are there fibrous, irregular textures visible at the periphery of a mass?", "Do you observe radiopaque (white) lines radiating outward from a central lesion?", "Is there a region where the projections measure between 1 and 10 millimeters in length?"], "relational": ["Does the image show a mass or nodule with radiating lines extending from its border?", "Is there a lesion present that causes architectural distortion in the surrounding tissue?", "Can you identify a structure with irregular borders that might indicate infiltration into adjacent connective tissue?", "Is there evidence of a boundary between a mass and the surrounding stroma marked by radiating extensions?", "Does the image contain a region in the breast, lung, or liver where a mass displays outwardly radiating features?", "Can you see a mass whose margins suggest a desmoplastic response or fibrosis in the adjacent tissue?", "Is there a lesion with features consistent with neoplastic or malignant growth, such as spiculated extensions?", "Does the image show a tumor or nodule where the interface with fat, parenchyma, or connective tissue is irregular and radiating?", "Can you identify a mass that could be associated with conditions like breast carcinoma or pulmonary malignancy based on its margin characteristics?", "Is there a structure whose outwardly radiating margins suggest infiltrative growth or irregular extension into the surrounding tissue?"], "contexual_behavior": ["Does the image show a lesion with radiating features that are more pronounced, suggesting possible tissue invasion or desmoplastic reaction?", "Is there evidence of radiating margins that have decreased in visibility, which could indicate a response to cancer therapy or tumor regression?", "Can you identify a lesion with irregular radiating borders that might be associated with peritumoral stromal inflammation?", "Is there a structure with smoother, less distinct radiating edges, suggesting a benign process rather than aggressive invasion?", "Does the image display a lesion with radiating features that appear more prominent, possibly due to outwardly extending fibrotic tissue?", "Can you observe any changes in the radiating pattern of a lesion that might reflect hormonal influences on stromal composition or tissue density?", "Is there a lesion with more evident radiating features in areas that appear hypoxic, possibly due to increased fibrosis or abnormal blood vessel formation?", "Does the image contain a lesion where the radiating fibrous structures are disrupted or lost, which could be a result of tissue necrosis?", "Can you see a lesion where the definition of radiating margins appears altered, potentially due to rapid cellular proliferation and changes in the surrounding stroma?", "Is there a lesion where the radiating features are less reliable for distinguishing malignancy, possibly due to post-radiotherapy fibrosis mimicking or obscuring malignant characteristics?"], "functions": ["Does the image show a lesion with irregular, radiating extensions suggestive of invasive tissue behavior?", "Can you identify a structure displaying asymmetric or infiltrative growth patterns?", "Is there evidence of a lesion penetrating into adjacent tissues, indicating increased invasiveness?", "Does the image reveal disrupted boundaries between abnormal and normal tissue, suggesting abnormal tissue intermingling?", "Can you see features that might indicate local cellular spread or potential for metastasis?", "Is there a lesion with characteristics of deep or broad tissue infiltration, implying biological aggressiveness?", "Does the image show signs of tissue remodeling, such as areas of desmoplasia or fibrosis, around a lesion?", "Can you identify a region where immune cell access to a lesion might be hindered, affecting immune surveillance?", "Is there visual evidence of a lesion facilitating local invasion or resisting containment, contributing to disease progression?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure located within the male reproductive system that appears abnormal?", "Can you identify a lesion adjacent to the seminal vesicles, bladder, or rectum?", "Does the image show lymphatic involvement near the obturator or internal iliac lymph nodes?"], "contexual_behavior": [], "functions": ["Can you see any sign of partial or complete obstruction of the prostatic urethra that might lead to urinary retention?", "Is there evidence of local inflammation, such as immune cell infiltration or regions suggestive of cytokine release?", "Does the image reveal a region that could impair seminal fluid production and potentially affect fertility?"]}}, "dense masses": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show any structures that are round, oval, or irregular in shape and appear denser than the surrounding tissues?", "Can you identify any objects that range in size from a few millimeters to several centimeters?", "Is there a region in the image that appears white or gray in color and stands out from adjacent tissues?", "Do you see any areas with well-defined or sharply demarcated margins compared to nearby structures?", "Is there evidence of increased attenuation or higher density on the imaging study relative to surrounding tissues?", "Are there any regions that appear hyperechoic or particularly echogenic on ultrasound imaging?", "Can you detect any structures that might have a firm or hard texture based on their appearance?", "Is there a visible area that could contain tightly packed cells, fibrous tissue, or mineralized material?", "Do any structures exhibit signs of calcification or fibrosis within their internal architecture?", "Is there a region that appears to have low water content compared to adjacent soft tissues?", "Can you identify any objects that might have high mineral content, such as calcium deposits?", "Are there any areas that display homogeneous or heterogeneous internal patterns?", "Do you see any structures whose volume or weight appears variable depending on their anatomical context?", "Is there evidence of high cellularity, abundant stroma, or matrix within any of the visible masses?"], "relational": ["Does the image show a structure within the breast, lymphatic system, or musculoskeletal system that appears unusually dense?", "Can you identify a region in the abdomen or pelvis that contains a compact or solid-appearing area?", "Is there a visible area in the image that is associated with epithelial, connective, or glandular tissue and appears denser than its surroundings?", "Does the image display a structure adjacent to blood vessels, nerves, fatty tissue, or muscles that stands out due to its density?", "Can you see a region that could contain cell types such as epithelial cells, fibroblasts, immune cells, or stromal cells grouped together densely?", "Is there evidence of a dense area within organs like the liver, thyroid, kidneys, or lymph nodes?", "Does the image show a structure that appears to interact with surrounding connective tissue, for example by encapsulation, infiltration, or compression?", "Can you identify a dense region whose boundaries are defined by fascial planes, organ capsules, or tissue interfaces?", "Is there a dense area that seems to be part of a larger anatomical structure, such as an organ, lobe, gland, or tumor complex?", "Does the image contain a region with imaging characteristics such as increased ultrasound echogenicity, high mammographic density, elevated CT attenuation, or altered MRI signal intensity?"], "contexual_behavior": ["Is there a structure in the image that appears to compress or invade nearby tissues, potentially leading to loss of normal physiological activity?", "Can you identify an area that might show increased metabolic activity in response to inflammation, possibly indicated by signs of inflammatory cell presence?", "Does the image reveal a region where local blood flow could be disrupted due to obstruction or vascular remodeling?", "Is there evidence of a structure whose growth rate or appearance might be influenced by low oxygen levels, such as increased blood vessel formation?", "Can you see a region that could act as a physical barrier to immune cell infiltration or might be secreting factors that suppress immune response?", "Does the image show a structure with signs of reduced structural integrity, possibly due to infection or matrix degradation?", "Is there an area that might not respond to hormonal signals, perhaps due to loss of receptor expression or disrupted signaling pathways?", "Can you identify a region that appears to exert pressure on surrounding organs by occupying limited anatomical space?", "Does the image show a structure where cellular turnover seems decreased, possibly as a result of therapy-induced proliferation inhibition?", "Is there evidence of enhanced blood vessel formation in a region that may be experiencing nutrient deprivation or hypoxia?", "Can you see a structure that might be more resistant to programmed cell death, potentially indicating disease progression?", "Is there a region where secretory activity could be altered in response to cytokine signaling, such as increased production of growth factors or enzymes?", "Does the image contain a structure whose rapid expansion could impair the function of a nearby organ?", "Is there visual evidence of a region whose size or activity has decreased following treatment, suggesting a reduction in its functional impact?", "Can you identify an area with increased extracellular matrix deposition, possibly indicating fibrotic changes due to activated fibroblasts?"], "functions": ["Is there a structure in the image that appears to provide support within the tissue?", "Can you identify an area that might be causing obstruction or blocking normal tissue pathways?", "Does the image show any region that could be compressing or displacing healthy cells?", "Is there evidence of tissue infiltration by an abnormal mass?", "Can you see a feature that might be influencing cell proliferation or apoptosis in the surrounding tissue?", "Is there a region that could be involved in remodeling the extracellular matrix?", "Does the image show any alteration in the mechanical properties of an organ, such as increased firmness or rigidity?", "Is there visible enlargement of an organ that could be attributed to an abnormal structure?", "Can you identify a feature that might be impairing the normal function of an organ?", "Is there a region that could be facilitating tumor growth, fibrosis, or chronic inflammation?", "Does the image show evidence of invasion or adhesion to surrounding tissues?", "Can you see any local tissue reactions, such as swelling or discoloration, near an abnormal structure?", "Is there a structure that appears to compress blood vessels or obstruct circulation?", "Can you identify an area that might be disrupting normal cell-cell communication or releasing signaling molecules?", "Does the image suggest recruitment of immune cells or the presence of an immunosuppressive environment near an abnormal mass?", "Is there a region that could be contributing to structural support if benign, or causing dysfunction if pathological?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a round or oval structure within the nucleus measuring between 1 and 5 micrometers in diameter?", "Is there a dense, smooth, and homogeneous object located centrally or near the periphery of the nucleus?", "Can you observe a nuclear inclusion that may contain viral proteins, cellular proteins, or nucleic acids such as DNA or RNA?"], "relational": ["Can you see any nuclear changes in larger structures like the brain, liver, or skin?", "Do you observe inclusions in the nuclei of neurons, hepatocytes, or epithelial cells?", "Are there intranuclear objects that appear near the endoplasmic reticulum or nucleolus?"], "contexual_behavior": [], "functions": ["Does the image show a subnuclear structure that could be involved in compartmentalizing or regulating nuclear activities?", "Is there evidence of a nuclear structure that could regulate processes such as transcription, RNA processing, or protein degradation?", "Is there a nuclear structure present that might interfere with DNA replication or repair by trapping essential factors or altering nuclear architecture?"]}}, "mammograms": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image appear to have dimensions similar to standard medical imaging sizes, such as 18 x 24 cm or 24 x 30 cm?", "Can you determine if the image resolution is fine enough to distinguish features at approximately 50 microns per pixel?", "Is there evidence that the grayscale depth in the image allows for 12 to 16 bits per pixel?", "Does the image suggest that it was acquired using a process delivering a radiation dose of about 1 to 2 milligray per view?", "Can you infer if the pixel spacing in the image is within the range of 0.05 mm to 0.1 mm?", "Does the image show contrast levels optimized for differentiating soft tissue structures?", "Is there any indication that the image format follows the DICOM standard?", "Can you identify regions in the image that could be categorized as fatty, scattered, heterogeneously dense, or extremely dense tissue?", "Does the image suggest that a compression force between 10 and 20 kilograms was applied during acquisition?", "Is the field of view broad enough to include the entire breast, pectoral muscle, and axillary tail?", "Can you infer if the image acquisition duration was approximately 1 to 2 seconds per exposure?", "Does the image show tissue thickness in the range of 2 cm to 6 cm?", "Is the noise level in the image low, consistent with high signal-to-noise ratio requirements?", "Does the image display a dynamic range that could represent 4096 to 65536 gray levels?", "Is the background brightness in the image adjusted to enhance lesion visibility and reduce glare?"], "relational": ["Does the image show anatomical features such as ducts or lobules within a specific region of the body?", "Can you identify glandular, adipose, or fibrous connective tissue in the visualized area?", "Is there a visible anatomical landmark such as a nipple, skin line, or inframammary fold?", "Does the image include regions like the upper outer quadrant or retroareolar area?", "Can you see the relationship between breast tissue and lymphatic structures such as axillary or intramammary lymph nodes?", "Is there evidence of anatomical variations such as differences in density, size, shape, or the presence of implants?", "Are structures adjacent to the breast, like the pectoralis major muscle, ribs, or axilla, visible in the image?", "Can you distinguish between dense glandular tissue and fatty tissue in the visualized area?", "Does the image appear to be acquired in a specific anatomical plane, such as cranio-caudal or medio-lateral oblique?"], "contexual_behavior": ["Does the image suggest the presence of dense tissue that could reduce the sensitivity of tumor detection, particularly in younger individuals?", "Can you identify features that might indicate high breast density, which is associated with lower diagnostic accuracy in certain age groups?", "Is there evidence of hormonal influences, such as those seen during the menstrual cycle or pregnancy, that could increase the likelihood of false-positive findings?", "Does the tissue composition appear more fatty, as might be expected after menopause, potentially improving the sensitivity of the imaging?", "Are there visual signs of breast implants that could obscure tissue and limit the identification of early-stage abnormalities?", "Can you detect patterns that might be consistent with inflammatory conditions, which could reduce the specificity of the findings?", "Is there an increased presence of glandular tissue or density that could be associated with hormone replacement therapy and a higher rate of detected abnormalities?", "Do you observe any evidence of prior surgical intervention, such as scar tissue or altered anatomy, that might decrease the effectiveness of the imaging?", "Are there overlapping structures or cystic patterns that could indicate cystic breast disease and reduce the reliability of the interpretation?", "Does the image suggest increased glandular tissue, as might occur during pregnancy or lactation, potentially altering the diagnostic role of the imaging?", "Is there evidence of tissue fibrosis or architectural distortion that could be related to prior radiation therapy and lead to inconclusive results?", "Can you identify features that might benefit from digital imaging technology, especially in individuals under 50 or those with dense tissue?", "Does the image suggest rapid changes in tissue that could make monitoring treatment response in aggressive conditions more challenging?", "Are there visual cues of reduced adipose tissue, such as after weight loss, which could enhance image clarity and increase detection rates?", "Do you notice any technical artifacts, such as motion blur or improper positioning, that could decrease the interpretive accuracy of the imaging?"], "functions": ["Does the image provide information that could be used for the detection or assessment of breast cancer?", "Can you identify any suspicious lesions or abnormalities that might be visualized before clinical symptoms appear?", "Is there evidence in the image that could be used to monitor changes in breast tissue over time?", "Does the image appear suitable for use in a population-based screening program aimed at early detection of disease?", "Can you see features that might guide further diagnostic procedures such as biopsies or additional imaging studies?", "Is there visual information that could help evaluate the response to breast cancer treatment by documenting changes in tumor size or characteristics?", "Are there lesions present whose radiographic features, such as shape, margins, or density, could help differentiate between benign and malignant findings?", "Does the image reveal patterns or findings, such as dense tissue, that could contribute to breast cancer risk assessment?", "Can you identify microcalcifications that may serve as early indicators of ductal carcinoma in situ or other pathologies?", "Is there detailed anatomical information present that could aid in planning surgical or therapeutic interventions by localizing lesions and assessing their size or extent?"]}, "no_questions": {"contexual_properties": ["Can you identify an ovarian feature that may represent a temporary endocrine gland with hemorrhagic characteristics?", "Does the image contain an ovarian entity that might be responsible for progesterone production and appears to have blood-filled areas?", "Is there a visible ovarian structure that could be involved in the menstrual cycle and shows signs of internal hemorrhage?"], "properties": ["Is there a round or oval structure measuring between 2 and 5 centimeters in diameter visible in the image?", "Does the image show a complex cyst with mixed echogenicity and reticular internal echoes, as might be seen on ultrasound?", "Can you see a structure whose wall thickness appears to be between 2 and 6 millimeters?"], "relational": ["Is there evidence of localized hemorrhage or enlargement within the ovary?", "Does the image contain a structure adjacent to developing follicles or the ovarian medulla?", "Can you identify an object located within the ovary?"], "contexual_behavior": ["Is there a visible ovarian structure that appears to have hemorrhagic features?", "Can you identify an area within the ovary that shows signs of recent or ongoing hemorrhage?", "Does the image contain a structure that could represent a corpus luteum with evidence of bleeding or blood accumulation?"], "functions": ["Does the image contain an object responsible for inducing secretory changes in the endometrium?", "Does the image show a structure that prevents endometrial shedding by maintaining the uterine lining through progesterone production?", "Is there a feature that plays a role in regulating hormonal balance and supporting implantation conditions?"]}}, "invasive breast carcinomas": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion originating from epithelial tissues of the mammary ducts or lobules?", "Can you identify a mass that appears to invade surrounding adipose or connective tissue?", "Is there evidence of involvement of the skin by an abnormal structure in the breast region?", "Does the image display any changes in axillary, internal mammary, or supraclavicular lymph nodes?", "Can you see a structure affecting the integumentary system, specifically within the breast?", "Is there an abnormality located in the upper outer quadrant of the breast?", "Does the image contain areas with malignant epithelial cells, fibroblasts, lymphocytes, or macrophages?", "Is there visible disruption or infiltration of normal breast tissue architecture?", "Can you identify involvement of blood vessels such as branches of the internal mammary artery or lateral thoracic artery?", "Does the abnormality appear to extend toward the pectoral fascia, chest wall, or overlying skin?", "Is there evidence of risk to chest wall muscles, lymphatic vessels, or distant organs due to the progression of a lesion in the breast?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal cell clusters invading surrounding tissue?", "Can you identify areas where normal glandular structures are disrupted or replaced by atypical cells?", "Is there visual indication of cells breaching the basement membrane and infiltrating the stroma?", "Does the image reveal malignant cells within blood vessels or lymphatic channels, suggesting potential for distant spread?", "Are there signs of local inflammation or immune cell infiltration near abnormal tissue regions?", "Can you observe new blood vessel formation in association with abnormal cell growth?", "Is there evidence of altered hormone receptor expression, such as changes in estrogen or progesterone signaling markers?", "Does the image show lymphatic vessel involvement or enlarged lymph nodes adjacent to abnormal tissue?", "Are there features suggesting recruitment of stromal cells or changes in the extracellular matrix composition around the lesion?", "Can you detect areas where antigen presentation appears reduced or where immune cells are excluded from the abnormal tissue?", "Is there visual evidence of increased cellular proliferation or reduced cell death within the abnormal region?", "Do you see signs of extracellular matrix degradation, such as loss of structural integrity or presence of matrix remodeling enzymes?", "Are there indications of systemic effects, such as tissue wasting or inflammatory changes, that could be linked to cytokine release from the abnormal area?"]}, "no_questions": {"contexual_properties": ["Does the facial swelling show indentation after pressure, indicating pitting edema?", "Is there asymmetric facial swelling that could be due to localized infection, trauma, or lymphatic blockage?", "Can you identify puffiness of the face that might be related to fluid overload, heart failure, or kidney problems?"], "properties": ["Is the swelling or puffiness bilateral, involving both sides of the face?", "Is there evidence of swelling that appears moderate, or does it range from mild to severe?", "Do the facial tissues look soft, or do they give the impression of being doughy or spongy?"], "relational": ["Are there structural changes in the scalp, neck, or periorbital tissues connected to facial swelling?", "Can you see features suggesting involvement of loose areolar tissue, collagen fibers, or the extracellular matrix in the affected facial areas?", "Does the image show swelling in areas such as the periorbital region, cheeks, or lips?"], "contexual_behavior": [], "functions": ["Can you observe features consistent with increased hydrostatic pressure, reduced plasma protein levels, or possible lymphatic obstruction in the face?", "Does the image show signs of facial swelling that could impair expression or cause discomfort?", "Does the facial appearance indicate a disruption in tissue fluid homeostasis, such as an imbalance between filtration and reabsorption?"]}}, "adjacent radiolucent breast tissue": {"yes_questions": {"contexual_properties": ["Is there a region that appears thicker than usual, possibly indicating inflammation, edema, or hormonal changes?", "Can you identify an area that seems reduced in volume, which might suggest atrophy, fibrosis, or the effects of radiation therapy?", "Does any tissue appear less radiolucent, potentially due to increased fibroglandular tissue, edema, or tumor cell infiltration?", "Is there a zone with increased density that could be associated with inflammatory processes, fibrosis, or neoplastic involvement?", "Can you see evidence of edematous changes, possibly resulting from trauma, infection, or lymphatic obstruction?", "Is there a region where the texture appears altered, which might be due to fibrosis, edema, or fat necrosis?", "Are abnormal calcifications present that could be linked to ductal carcinoma in situ, fat necrosis, or chronic inflammation?", "Do you observe increased vascularity in any area, which may be a sign of inflammation, tumor angiogenesis, or infection?", "Is there a region that appears more infiltrated by fat, possibly reflecting aging, weight gain, or involutional changes?", "Can you identify signs of fibrosis, potentially following chronic inflammation, radiation therapy, or surgery?", "Is there evidence of compression in any tissue, which could be caused by a mass, hematoma, or external pressure during mammography?", "Does any area appear swollen, possibly in response to acute inflammation, trauma, or an allergic reaction?", "Is there a region that has lost its normal appearance, which might indicate malignancy, extensive fibrosis, or severe edema?", "Can you see signs of increased water content, such as those associated with edema, inflammation, or lymphatic congestion?", "Is there a region that appears less distinct on imaging, potentially due to overlapping dense tissue, edema, or post-surgical changes?"], "properties": ["Is there a region in the image that appears as an irregular or lobulated area of low attenuation?", "Can you identify a structure that is predominantly composed of adipose tissue with minor connective and sparse glandular elements?", "Does the image show a soft and pliable area, likely due to high fat content?", "Is there a region with low density, consistent with fat-rich tissue?", "Can you see an area whose typical thickness ranges from 1 to 3 centimeters?", "Is there a structure that would have a pale yellow to white appearance when observed grossly?", "Does the image contain a region where the radiodensity might fall between \u2013100 and \u201350 Hounsfield units?", "Can you identify an area that would have a water content of approximately 10\u201320% by weight?", "Is there a region where the fat or lipid content is estimated to be 80\u201390% of the tissue mass?", "Does the image show a structure with a relatively low protein content, around 1\u20132% by weight?", "Can you see an area where the collagen content is likely less than 5% by weight?", "Is there a region whose average volume could range from 10 to 100 cubic centimeters depending on location?", "Does the image include tissue that would have a physiological pH of approximately 7.4?", "Can you identify an area that would be composed of adipocytes, fibroblasts, and occasional stromal cells?"], "relational": ["Does the image show a region within the breast that is part of the mammary gland?", "Can you identify tissue that is located near both glandular and adipose components?", "Is there a structure that appears to surround or support the mammary glands?", "Does the image contain areas adjacent to dense glandular tissue and connective septa?", "Can you see tissue that is found close to fibroglandular and stromal connective tissue?", "Is there a region where adipocytes, fibroblasts, or vascular endothelial cells might be present?", "Can you identify connective tissue composed mainly of collagen fibers or interlobular stroma?", "Does the image show tissue associated with terminal duct lobular units or lactiferous ducts?", "Is there a visible layer corresponding to subcutaneous fat or the retromammary space?", "Can you see anatomical boundaries defined by the interface between glandular and adipose tissue or by connective septa?"], "contexual_behavior": [], "functions": ["Does the image show a region within the breast that appears to provide support and cushioning for surrounding structures?", "Can you identify an area that serves as a matrix for vascular or ductal elements in the breast?", "Is there evidence of tissue that maintains the position and integrity of glandular structures?", "Does the image reveal a component that modulates the balance between adipose and fibrous elements in the breast?", "Can you observe a region that might change in volume or cellular composition in response to hormonal fluctuations?", "Is there a structure that appears to influence fluid distribution through its extracellular matrix or vascular features?", "Does the image contain a scaffold-like area that helps maintain breast shape and resilience?", "Can you see tissue that might remodel or adapt during physiological changes such as lactation or involution?", "Is there a region that could be involved in lipid storage or nutrient exchange, supporting metabolic activity?", "Does the image show a component that allows for breast flexibility and mobility while preserving structural integrity?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Are there visual cues that the immune, skeletal, nervous, or respiratory systems might be affected by disease progression?", "Is there evidence of tumor involvement near breast lobules, ducts, pectoral muscles, or the skin?", "Can you see any indications of metastatic spread to the lungs, liver, brain, or bones?"], "contexual_behavior": [], "functions": ["Is there indication of a modified tumor microenvironment, such as recruitment of immunosuppressive cells or remodeling of the extracellular matrix?", "Does the neoplastic region show increased cell proliferation or survival, possibly due to upregulated growth factor signaling or inhibition of cell cycle checkpoints?", "Does the image show a tumor lacking expression of estrogen receptor, progesterone receptor, and HER2?"]}}}
[ { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "face" ], "question": "is face present?" }, { "answer": "no", "extracted_concepts": [ "test tube", "pus" ], "question": "is pus in test tube present?" }, { "answer": "potters facies", "extracted_concepts": [ "potters facies" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "potters facies" ], "question": "is potters facies present?" }, { "answer": "face", "extracted_concepts": [ "face" ], "question": "what is present?" }, { "answer": "potters facies", "extracted_concepts": [ "potters facies" ], "question": "what is present?" } ]	["test tube", "potters facies", "pus", "face"]	{"test tube": {"yes_questions": {"contexual_properties": ["Is there an object in the image that appears discolored, possibly due to exposure to chemicals or heat?", "Can you identify a structure that shows residue buildup, suggesting incomplete cleaning or evaporation of solutions?", "Does the image contain an item with visible cracks, which could result from mechanical stress or rapid temperature changes?", "Is there an object whose weight might have changed after use because of remaining residues or evaporation?", "Can you see a structure that looks cloudy, potentially due to deposition of insoluble materials or surface etching?", "Does any object in the image show accumulation of precipitate from a chemical reaction?", "Is there a structure with altered transparency, possibly caused by internal deposits, scratches, or chemical reactions?", "Can you identify an item with stains that may have resulted from chemical reactions producing colored byproducts?", "Does the image show a structure that could experience changes in internal pressure during heating or gas evolution?", "Is there an object that appears etched, possibly due to exposure to corrosive substances like strong acids or bases?", "Can you see contents that have changed color, perhaps due to a chemical reaction, pH shift, or indicator use?", "Is there a structure whose contents are separated into layers, indicating the presence of immiscible liquids or phases?", "Does the image contain an object with contents that have increased in volume, possibly from gas evolution, heating, or addition of reagents?", "Can you identify a structure whose contents have decreased in volume, perhaps due to evaporation, sampling, or chemical consumption?", "Is there an object whose contents appear more viscous, possibly as a result of concentration, polymerization, or precipitation?"], "properties": ["Does the image show an object with a cylindrical shape and a rounded bottom?", "Can you identify a structure that appears transparent or clear?", "Is there an object present that could have a volume capacity between 5 mL and 50 mL?", "Can you see something with a length likely between 75 mm and 150 mm?", "Is there a structure with a diameter in the range of 10 mm to 20 mm?", "Does the image contain an object that might be made from borosilicate glass, polypropylene, or polystyrene?", "Can you identify an object with a wall thickness of about 1 mm to 2 mm?", "Is there a structure that could weigh between 10 grams and 20 grams when empty?", "Does the image show an object with a smooth, flared rim?", "Can you see a structure with a labeling area approximately 20 mm by 40 mm?", "Is there an object that could withstand temperatures up to 500\u00b0C if made from borosilicate glass?", "Can you identify a structure that might exhibit high resistance to chemical corrosion?", "Does the image contain an object that could tolerate internal pressures up to about 1 atmosphere?", "Is there a structure whose melting point might be around 820\u00b0C if made from borosilicate glass?"], "relational": ["Does the image show an object commonly used in clinical chemistry or hematology procedures?", "Can you identify a container that might hold blood samples or reagents?", "Is there a vessel present that could contain culture media for microbiology?", "Does the image include an item that is typically supported by a rack or holder designed for cylindrical glassware?", "Can you see any racks, holders, or clamps that are used to support cylindrical laboratory containers?", "Is there a structure that could be placed in a centrifuge for sedimentation or separation by centrifugal force?", "Does the image show a process such as sample collection, mixing, incubation, or centrifugation involving a small cylindrical vessel?", "Can you identify glassware that is structurally similar to a culture tube or centrifuge tube?", "Is there a container with a closure such as a rubber stopper, screw cap, or plastic cap?", "Does the image show a device like a needle, syringe, or transfer pipette being used to transfer a specimen into a small cylindrical container?", "Is there a vessel that might contain anatomical samples such as blood, urine, or saliva?"], "contexual_behavior": ["Is there an object in the image whose ability to contain biological reactions could be compromised if exposed to extreme temperatures?", "Can you identify a vessel whose sterility might be affected by improper sealing or exposure to a non-sterile environment?", "Is there a container present that could have its function as a reaction vessel impaired by residual chemicals from previous uses?", "Does the image show an item whose capacity to support cell culture would decrease if its surface integrity were compromised by poor storage conditions?", "Is there a vessel in the image that could fail to preserve sample integrity if exposed to prolonged light, especially for photosensitive contents?", "Can you see an object whose role in separating blood components would depend on the speed of centrifugation, affecting the formation of distinct layers?", "Is there a container whose effectiveness in preventing evaporation might be reduced in a low humidity environment, leading to sample loss?", "Does the image include a vessel whose efficiency in mixing samples could be hindered by high viscosity solutions?", "Is there an object present whose ability to support enzymatic reactions would decrease if the pH level is not optimal for enzyme activity?", "Can you identify a vessel whose function in maintaining sample stability could be affected by rapid temperature changes, potentially causing condensation or denaturation?"], "functions": []}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of a reproductive structure capable of producing thousands of eggs per cycle?", "Is there an object that could survive in a pH range between 6 and 8?", "Does the image contain an object that might tolerate temperatures between 20 and 40 degrees Celsius?"], "relational": ["Is there a visible entity that could have entered through the oral cavity or digestive tract?", "Can you see signs of egg deposition or irritation in the perianal area?", "Is there evidence of a structure affecting the perianal region or lower intestine?"], "contexual_behavior": ["Is there evidence of a parasite that migrates toward the perianal region during host sleep for optimal egg deposition?", "Is there an organism that increases its nocturnal activity to deposit eggs on the perianal skin, emerging at night in sync with the host's circadian rhythm?", "Is there evidence of a parasite that increases its transmission in crowded living conditions due to higher rates of person-to-person contact?"], "functions": ["Does the image show features consistent with a local inflammatory response or mild eosinophilia in the tissue?", "Does the image show features that could be associated with direct contact transmission between hosts?", "Is there a structure that could be responsible for gastrointestinal symptoms such as abdominal discomfort?"]}}, "potters facies": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a face with a flattened and broad nasal bridge?", "Can you identify a small and receding chin in the image?", "Is there evidence of widely spaced eyes or increased distance between the eyes?", "Does the face appear to have flat cheeks or poorly defined cheekbones?", "Are the ears positioned lower than usual or do they appear abnormally shaped?", "Is the mouth downturned or does it have a small oral opening?", "Can you observe loose or wrinkled skin, especially around the face?", "Does the skin color appear normal or is there any sign of pallor?", "Are prominent epicanthal folds visible near the eyes?", "Is there a marked degree of micrognathia present?", "Do the lips appear thin or pursed?", "Are multiple facial features flattened or lacking normal contour?"], "relational": ["Does the image show facial features such as a flattened nasal bridge or recessed chin?", "Can you identify low-set ears or epicanthal folds in the facial structures present?", "Is there evidence of abnormalities in the midface, periorbital region, or mandibular area?", "Are there visible alterations in the skin, subcutaneous tissue, or cartilage of the face?", "Does the image reveal skeletal changes involving the mandible, maxilla, or nasal bones?", "Can you observe features that might suggest an association with conditions like Potter sequence or bilateral absence of kidneys?", "Is there any indication of developmental issues such as oligohydramnios reflected in the facial appearance?", "Are there signs of anomalies in the craniofacial system that could be linked to the urinary system?", "Does the image show other congenital anomalies such as limb deformities, underdeveloped lungs, or clubfoot?"], "contexual_behavior": ["Does the image show facial features that could be associated with prolonged or severe deficiency of amniotic fluid during gestation?", "Are there signs of facial changes that might be less pronounced if some renal function and amniotic fluid volume were preserved?", "Can you identify a face that appears unaffected, possibly indicating that any reduction in amniotic fluid was only temporary and resolved before critical development periods?", "Is there evidence of facial characteristics that could be modified or overlapped due to the presence of another craniofacial syndrome?", "Does the image suggest more severe facial alterations that might result from early-onset absence of kidney development and extended periods of low amniotic fluid?", "Are there facial features that appear less distinct, potentially indicating that amniotic fluid levels normalized before mid-gestation?", "Can you see facial variations that might be explained by amniotic fluid loss from causes other than kidney problems, such as chronic leakage?", "Does the image lack the typical facial changes expected when urinary tract obstruction is mild and amniotic fluid remains sufficient?", "Are there visual signs of severe facial flattening that could be linked to impaired airway passages?", "Is there evidence of malformations around the mouth or nose that might contribute to feeding or breathing difficulties in a newborn?"], "functions": ["Does the image show a newborn with facial features that could compromise breathing or cause airway obstruction?", "Is there evidence of facial structure that might interfere with feeding or sucking ability in an infant?", "Can you identify features that suggest an increased risk of aspiration due to altered protective facial anatomy?", "Does the image reveal signs of limited facial muscle function, such as reduced mobility or weakness?", "Is there any indication of oral or facial malformations that could delay or impair speech development?", "Do you observe eyelid abnormalities or reduced facial tone that might hinder effective blinking or eye protection?", "Is there visual evidence of poor oral competence, such as drooling or difficulty controlling saliva?", "Does the facial appearance suggest diminished ability to express emotions or reduced facial expressivity?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of hemorrhage in a localized area, or is the region notably pale, suggesting different types of tissue injury?", "Is there a zone with decreased tissue density compared to the surrounding area?", "Is there a granular or friable texture present in any part of the tissue, possibly progressing to a more fibrotic appearance?"], "relational": ["Is there visual evidence of a process such as ischemia, thrombosis, or embolism affecting the tissue?", "Does the image show evidence of tissue disruption or loss of normal architecture in regions such as the myocardium or brain tissue?", "Does the image display changes in the cerebral cortex, myocardial wall, renal cortex, or pulmonary lobes that suggest localized damage?"], "contexual_behavior": [], "functions": ["Is there evidence of an inflammatory response, such as immune cell infiltration, near a damaged tissue area?", "Is there a visible area where normal biological processes such as oxygen delivery or nutrient exchange might be impaired?", "Can you see signs of compromised cellular metabolism, such as regions that might be experiencing hypoxia?"]}}, "pus": {"yes_questions": {"contexual_properties": ["Is there a substance in the image that appears thicker, possibly indicating a prolonged infection or dehydration?", "Can you observe a material whose color varies, suggesting differences in the type of infecting organism, presence of blood, or stage of inflammation?", "Is there evidence of a watery exudate that might indicate an early or acute infection?", "Does the image show an accumulation of fluid and cells that could increase in volume with an active inflammatory response?", "Can you identify an area where the volume of a discharge appears reduced, possibly due to resolution, drainage, or immune clearance?", "Is there a visible exudate that might be associated with a foul odor, suggesting anaerobic infection or tissue necrosis?", "Do you see a substance containing visible blood, which could indicate capillary damage or tissue injury at the site?", "Is there a greenish coloration present, possibly due to high neutrophil activity or association with Pseudomonas infection?", "Can you detect a yellowish discharge that might result from the accumulation of dead neutrophils and cellular debris?", "Is there a brownish tint to any exudate, suggesting the presence of degraded blood products or chronic infection?", "Does the image show a collection that could contain a high number of bacteria, indicating active or uncontrolled infection?", "Is there a thin, less viscous fluid present that might be due to dilution by serous fluid or an early stage of infection?", "Can you observe a discharge that may have increased protein content, potentially due to extensive tissue breakdown or high leukocyte turnover?", "Is there evidence of a material with abundant dead cells, reflecting an intense immune response or leukocyte apoptosis?", "Do you see signs that a substance might be more acidic, possibly due to intense bacterial metabolism or anaerobic infection?", "Is there an area where the exudate could be more alkaline, perhaps due to ammonia production by certain bacteria?", "Can you identify changes in the cellular makeup of a discharge, suggesting progression of infection or infiltration by different immune cells?", "Is there a large accumulation of fluid that could indicate abscess formation or impaired drainage?", "Does the image show a thickened material that might result from fluid evaporation at a wound or drainage site?", "Can you observe changes in the consistency of a discharge that might reflect shifts in cellular content, protein concentration, or fluid balance during infection progression?"], "properties": ["Does the image show a substance that appears yellow, green, or white?", "Is there a material with a thick, creamy, or viscous consistency present?", "Can you identify a fluid that might have a foul or unpleasant odor?", "Is there evidence of a substance with high water content, making up most of its volume?", "Does the image contain material that could be rich in neutrophils or macrophages?", "Is there a collection of fluid that might have a protein concentration between 3 and 6 g/dL?", "Can you see a substance that is likely to have low lipid content, less than 1%?", "Is there a fluid accumulation that could have a glucose level lower than that of blood?", "Does the image show a collection whose volume could range from a few milliliters to over a hundred milliliters?", "Is there a substance present that might have a density slightly higher than water, around 1.03 to 1.05 g/mL?", "Can you identify a material that is likely to be at or near body temperature?", "Does the image show a collection that could contain a high concentration of bacteria?", "Is there evidence of a fluid with a very high white blood cell count?", "Can you see a substance that might contain abundant dead cells or cellular debris?", "Is there a material present that could exhibit high viscosity due to its cellular and protein content?", "Does the image suggest the presence of a fluid with elevated levels of enzymes such as lysozyme or proteases?", "Is there a collection that might contain significant amounts of sodium, potassium, or chloride?", "Can you identify a substance that could have high concentrations of inflammatory mediators like cytokines or chemokines?"], "relational": ["Does the image show evidence of acute inflammation in tissues such as the skin, lungs, or mucous membranes?", "Can you identify a region that might contain neutrophils or dead macrophages?", "Is there a visible accumulation that could be associated with bacteria within tissue spaces or wounds?", "Does the image contain a localized collection within an abscess cavity?", "Can you see a structure that might be surrounded by an abscess wall or fibrous capsule?", "Is there an area that appears to be lined by epithelial tissue and contains cellular debris?", "Does the image show a feature that could represent a fistula, sinus tract, or surgical drain facilitating the removal of material from a tissue space?", "Can you identify a collection in subcutaneous tissue, the oral cavity, pleural cavity, or peritoneal cavity?", "Is there a region that suggests the presence of an infected wound resulting from an immune response to bacterial invasion?", "Does the image show a protein-rich fluid containing leukocytes and bacteria within a wound or tissue space?"], "contexual_behavior": ["Does the image show evidence of increased neutrophil response and bacterial lysis, suggesting an acute infection?", "Is there a sign of localized accumulation that could indicate inefficient drainage or a robust immune response?", "Can you identify features that might suggest reduced pus production, such as after antibiotic therapy or surgical debridement?", "Does the image reveal a viscous, dense accumulation that could be associated with chronic inflammation and high protein content?", "Is there visual evidence of wound healing that might be facilitated by drainage or debridement of infectious material?", "Can you see persistent accumulation that could be due to impaired phagocytosis or chronic infection, possibly in an immunocompromised individual?", "Does the image suggest slowed formation or minimal accumulation, as might be seen in immunosuppressed patients with low neutrophil counts?", "Is there a localized, encapsulated collection that could indicate abscess formation with tissue necrosis?", "Can you identify features suggesting the presence of a foreign body, ongoing inflammation, or persistent infection?", "Does the image show changes in the appearance of the accumulation that could correspond to different stages of infection, such as varying cellular or protein content?", "Is there evidence of neutrophilic inflammation that might be triggered by fungal pathogens?", "Does the image lack prominent accumulation, which could suggest a viral infection with minimal neutrophil activity?", "Can you see signs of impaired drainage, such as tissue fibrosis or chronic inflammation obstructing outflow?", "Is there evidence of poor wound healing or chronic wounds that might be associated with diabetes mellitus and increased accumulation?", "Does the image suggest impaired healing or persistent accumulation that could be due to poor circulation or ischemia?", "Can you identify features that might indicate effective immune modulation, such as reduced inflammation and resolution of infection?", "Is there a rapidly accumulating collection in deep tissue, possibly due to poor drainage and extensive tissue necrosis?", "Does the image suggest altered suppurative processes that could be related to autoimmune disease or sterile inflammation?", "Is there evidence of delayed healing or persistent accumulation that might be seen in malnourished individuals with impaired immunity?"], "functions": ["Does the image show evidence of a substance involved in collecting and removing dead cells or debris from an area of infection?", "Can you identify an accumulation that suggests the recruitment of neutrophils or other immune cells at a site of inflammation?", "Is there a visible feature that could indicate the containment or neutralization of invading microorganisms?", "Does the image display material that might be associated with the drainage of infected tissue or removal of pathogens?", "Can you see a localized collection that could be playing a role in isolating infection and facilitating tissue repair?", "Is there an area that appears to be clearing necrotic tissue or promoting the resolution of inflammation?", "Does the image include a structure that could represent a barrier preventing the spread of pathogens, such as an abscess?", "Can you identify a region where cellular debris and dead cells are being eliminated from infected tissues?", "Is there an accumulation that might act as an exudate mediating immune defense and tissue cleanup at a site of infection?", "Does the image show a medium where immune cells like neutrophils or macrophages are aggregating to target pathogens?"]}, "no_questions": {"contexual_properties": ["Is there a visual indication of elevated free fatty acids that could be associated with stress, fasting, or insulin resistance?", "Does the image suggest increased energy demand in muscle tissue, as would be expected during exercise when stored fats are mobilized for fuel?", "Can you identify features suggestive of metabolic disorders such as lipodystrophy, Cushing's syndrome, or diabetes, where lipid metabolism may be abnormal?"], "properties": ["Does the image suggest the requirement for cofactors like coenzyme A, NAD+, or FAD in a metabolic process?", "Is there any visual indication of a process that is more active during fasting conditions?", "Can you see evidence of glycerol concentrations in plasma within the range of 0.05\u20130.1 mmol/L?"], "relational": ["Does the image display structures such as intestinal villi or microvilli that enhance the absorption of nutrients?", "Does the image show any part of the digestive system involved in the processing of dietary fats?", "Does the image show the small intestine in a way that suggests active enzymatic digestion and absorption of lipids?"], "contexual_behavior": ["Can you identify signs of enhanced fat breakdown and possible ketone production, as might occur in uncontrolled diabetes?", "Does the image reveal rapid fat loss that could be consistent with cachexia and increased catabolic signaling?", "Can you see features indicating increased fat mobilization for heat production, as would occur during cold exposure?"], "functions": ["Does the image suggest support for cellular respiration via acetyl-CoA supply to the citric acid cycle?", "Can you see signs of triglyceride hydrolysis resulting in free fatty acids and glycerol?", "Can you observe features indicating interaction between fat and carbohydrate metabolism?"]}}, "face": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with a width of approximately 13 to 15 centimeters in adults?", "Can you identify an area with a height of about 18 to 20 centimeters in adults?", "Is there a region that appears oval, round, square, or heart-shaped?", "Does the image include an area where skin color ranges from very light to very dark tones?", "Can you see a surface area that could be estimated at around 500 to 600 square centimeters?", "Is there a visible distance between two features that could be about 6 to 7 centimeters apart?", "Can you identify a central protrusion with a length of approximately 5 to 6 centimeters?", "Is there a horizontal opening that appears to be 5 to 6 centimeters wide?", "Does the image show a region with smooth skin and fine pores?", "Can you see an area where fat might make up about 15 to 20 percent of the tissue mass?", "Is there a region where muscle could account for about 20 to 25 percent of the tissue mass?", "Does the structure contain layers such as skin, fat, muscle, connective tissue, nerves, and bone?", "Can you identify a region where bone density might be around 1.2 to 1.5 grams per cubic centimeter?", "Is there an area where water content could be estimated at 60 to 65 percent of total tissue weight?", "Does the image suggest the presence of 200 to 300 sweat glands per square centimeter?", "Can you see a region likely to contain 400 to 900 sebaceous glands per square centimeter?", "Is there an area where the temperature might be between 33 and 35 degrees Celsius?", "Can you identify a region where melanin concentration could range from 500 to 1200 units?", "Does the image show skin with an elasticity corresponding to a Young\u2019s modulus of 0.4 to 0.6 megapascals?", "Is there a region where the skin thickness appears to be about 1.5 to 2 millimeters?"], "relational": ["Does the image show a region located at the front of the head?", "Can you identify structures formed by bones such as the maxilla or mandible?", "Is there evidence of muscles like the orbicularis oculi or masseter in the image?", "Does the image contain organs such as the eyes, nose, or mouth?", "Can you see features that would be innervated by the facial or trigeminal nerves?", "Is there a visible area likely supplied by the facial artery or superficial temporal artery?", "Does the region in question border anatomical structures like the scalp, neck, or ears?", "Are tissues such as skin, subcutaneous tissue, or connective tissue present in the area?", "Can you identify sensory organs such as the eyes, nose, or tongue within the region?", "Is there a part of the image forming the front aspect of the skull, supported by the facial skeleton?"], "contexual_behavior": [], "functions": ["Does the image show a structure that enables communication through expressions or speech?", "Can you identify an area involved in sensory perception, such as vision, smell, taste, touch, or hearing?", "Is there a region that facilitates eating or speaking by providing features like lips, teeth, or tongue?", "Does the image contain evidence of emotional expression through coordinated muscle movements?", "Can you see bony or soft tissue structures that protect organs responsible for vision, smell, or ingestion?", "Is there a visible passageway that could allow airflow for breathing?", "Can you observe features that might contribute to temperature regulation, such as skin or blood vessels?", "Does the image display nonverbal social cues, like a smile, frown, or eyebrow movement?", "Is there a structure that houses taste buds or olfactory receptors for taste and smell perception?"]}, "no_questions": {"contexual_properties": [], "properties": ["Are cytoplasmic inclusions absent or rare in the most prominent cell in the center?", "Does the cytoplasm of the central cell look smooth to slightly granular in texture?", "Is the chromatin pattern in the nucleus of the central cell fine to moderately coarse?"], "relational": ["Is there visual evidence that the central prominent cell interacts with the extracellular matrix, such as through cell adhesion or matrix remodeling?", "Can you determine if the central prominent cell is part of a broader system, such as the immune, circulatory, or digestive system, based on its context?", "Is the anatomical region containing the central prominent cell best described as cortex, medulla, or parenchyma?"], "contexual_behavior": [], "functions": ["Can you see a central cell that could stimulate cell proliferation or differentiate into specialized cells?", "Is there a prominent cell in the center that might be controlling gene expression or secreting regulatory molecules?", "Can you see a prominent cell that might participate in immune defense, such as by presenting antigens or secreting cytokines?"]}}}
[ { "answer": "x-ray skull cap multiple lytic lesions prostate adenocarcinoma", "extracted_concepts": [ "prostate adenocarcinoma", "multiple lytic lesions", "skull cap", "x-ray" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "prostate adenocarcinoma", "multiple lytic lesions", "skull cap", "x-ray" ], "question": "does this image show x-ray skull cap multiple lytic lesions prostate adenocarcinoma?" }, { "answer": "no", "extracted_concepts": [ "great toe", "prostate adenocarcinoma", "multiple lytic lesions", "skull cap", "x-ray" ], "question": "does this great toe show x-ray skull cap multiple lytic lesions prostate adenocarcinoma?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "skull" ], "question": "is bone, skull present?" }, { "answer": "no", "extracted_concepts": [ "myoma lesion" ], "question": "is myoma lesion present?" }, { "answer": "metastatic carcinoma x-ray", "extracted_concepts": [ "x-ray", "metastatic carcinoma" ], "question": "what is present?" }, { "answer": "ray present", "extracted_concepts": [ "x-ray", "metastatic carcinoma" ], "question": "what is metastatic carcinoma x-ray?" }, { "answer": "yes", "extracted_concepts": [ "x-ray", "metastatic carcinoma" ], "question": "is metastatic carcinoma x-ray present?" }, { "answer": "no", "extracted_concepts": [ "siamese twins" ], "question": "is siamese twins present?" }, { "answer": "bone, skull", "extracted_concepts": [ "bone", "skull" ], "question": "what is present?" }, { "answer": "metastatic carcinoma x-ray", "extracted_concepts": [ "x-ray", "metastatic carcinoma" ], "question": "what is present?" }, { "answer": "ray present", "extracted_concepts": [ "x-ray", "metastatic carcinoma" ], "question": "what is metastatic carcinoma x-ray?" } ]	["great toe", "prostate adenocarcinoma", "bone", "metastatic carcinoma", "siamese twins", "multiple lytic lesions", "skull", "myoma lesion", "skull cap", "x-ray"]	{"great toe": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure located in the distal region of the lower limb within the foot?", "Can you identify a part of the foot that contains both a proximal and distal phalanx specific to the hallux?", "Is there a joint visible that could correspond to either a metatarsophalangeal or interphalangeal joint of the hallux?", "Does the image include a region where muscles such as the flexor hallucis longus, extensor hallucis longus, or abductor hallucis might attach?", "Can you see tendons that could belong to the flexor hallucis longus or extensor hallucis longus muscles?", "Is there an area that would likely receive nerve supply from the medial plantar nerve or deep peroneal nerve?", "Does the image show a region supplied by the dorsal digital artery or plantar digital artery?", "Can you identify supporting structures such as a plantar plate, collateral ligaments, or sesamoid ligaments in the medial forefoot?", "Is there a toe situated in the medial part of the forefoot, adjacent to the second toe, and appearing as the largest among the five toes?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides stability and balance during movement?", "Can you identify an object that increases the contact area of the foot to enhance balance while standing?", "Does the image show a part that plays a crucial role in walking or running by enabling effective push-off?", "Is there a feature that flexes at the metatarsophalangeal joint to generate force against the ground during gait?", "Can you see something that helps maintain posture by stabilizing the foot and supporting the body's upright position?", "Is there a structure that bears a significant portion of body weight during the stance phase of walking?", "Does the image contain an object that anchors the forefoot and prevents excessive rolling or shifting during movement?", "Can you identify a part that provides leverage and transmits muscular force to the ground to facilitate propulsion in locomotion?", "Is there a feature that helps absorb impact by flexing and adapting to ground forces, thereby reducing stress on other foot structures?", "Does the image show something that enables precise adjustments in toe positioning and grip for fine motor control of the foot?"]}, "no_questions": {"contexual_properties": ["Does the image show a pancreatic lesion with irregular or changing shape, which might suggest invasion into surrounding tissues or necrosis?", "Is there evidence of necrotic regions within a pancreatic mass, which could result from ischemia or effects of therapy?", "Do you observe calcifications within a pancreatic mass, which might result from chronic inflammation or tumor necrosis?"], "properties": ["Does the image show a pancreatic lesion with signs of necrosis affecting 10% to 40% of its area?", "Is there a region in the pancreas that could be composed of malignant epithelial cells, stromal cells, and infiltrating immune cells?", "Is there a pancreatic region that might exhibit low lipid content and relatively high protein content?"], "relational": ["Can you identify an organ located in the abdominal cavity, specifically within the retroperitoneal space or epigastric region?", "Is there evidence of secretions being transported by a main or accessory duct within the image?", "Does the image show a structure containing specialized cells like acinar cells, ductal cells, or islet cells (including alpha, beta, delta, or PP cells)?"], "contexual_behavior": ["Is there an organ that increases insulin output during pregnancy to meet higher metabolic demands?", "Is there evidence of inflammation or cellular injury that could impair the function of acinar and islet cells?", "Can you identify a structure that might exhibit reduced hormone secretion due to decreased islet cell function in aging?"], "functions": ["Does the image show evidence of cells that synthesize and release insulin in response to high blood sugar?", "Is there a region that participates in metabolic regulation by modulating hormone secretion?", "Does the image contain features associated with the production of digestive enzymes like proteases, lipases, or amylases?"]}}, "prostate adenocarcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion originating within a gland of the male reproductive system?", "Can you identify an abnormality involving glandular epithelial tissue surrounded by prostatic stroma?", "Is there evidence of a mass located near the bladder, rectum, or seminal vesicles?", "Does the image reveal any involvement of pelvic, obturator, or iliac lymph nodes?", "Can you see changes that might affect the urinary or reproductive systems?", "Is there a structure that could impact the skeletal or lymphatic systems due to disease progression?", "Does the abnormality appear to be located in the peripheral zone of a glandular organ?", "Is there any indication of involvement of the transitional or central zones within the gland?", "Can you observe blood vessels such as prostatic arteries, prostatic veins, or branches of the internal iliac vessels near the affected area?", "Does the image suggest possible spread through lymphatic vessels, venous plexuses, or by direct extension?", "Are there signs of invasion into the seminal vesicles, bladder neck, rectum, or neurovascular bundles?", "Can you detect features that might indicate tumor extension into the seminal vesicles, which could influence local staging?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Does the image show evidence of a structure adhering to an ovary located on the contralateral side?", "Can you identify any tissue or anatomical feature that is visually continuous with an ovary across to the other side?", "Is there a structure in the image that appears to be attached to an ovary on the opposite side?"], "properties": ["Can you see a fibrous band with high collagen content adjacent to the ovary on the other side?", "Is there a band-like tissue near the ovary that measures a few millimeters to several centimeters in length?", "Is there a structure near the ovary on the opposite side that appears irregular or band-shaped?"], "relational": ["Is there a visible adhesion between the omentum and a reproductive system component such as the fallopian tube or uterine horn?", "Is there a region where the mesovarium or pelvic peritoneum seems to be abnormally attached to a reproductive organ near the uterine horn?", "Does the image show any evidence of the ovarian artery or vein being involved in an adhesion with adjacent tissues?"], "contexual_behavior": ["Does the image show evidence of an anatomical entity adhering to an adjacent ovary on the contralateral side?", "Can you identify any tissue or anatomical feature that seems to be physically connected to an ovary across from it?", "Is there a structure in the image that appears to be attached to an ovary located on the opposite side?"], "functions": ["Is there any indication of inflammation or structural changes that could be associated with pain or potential infertility?", "Does the image show abnormal anatomical connections between structures that could restrict the mobility of an ovary?", "Is there a visible disruption in the normal pathway for gamete movement or evidence of a physical barrier affecting egg transport?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Does the image show a structure that appears to be increasing in size, suggesting disease progression or inadequate response to therapy?", "Is there a region with heterogeneous composition, displaying mixed areas of necrosis, hemorrhage, fibrosis, or viable tumor tissue?", "Can you see evidence of necrosis within a lesion, possibly due to insufficient blood supply or cytotoxic therapy?"], "properties": ["Is there an area where the water content appears normal or slightly increased, perhaps due to edema?", "Does any structure show signs of rapid or accelerated growth relative to other lesions?", "Can you identify an area that ranges in size from a few millimeters to several centimeters?"], "relational": ["Does the image show an abnormal area within epithelial, connective, nervous, or muscle tissue?", "Can you see a region that could contain malignant tumor cells along with stromal or immune cells?", "Does the image show an area located in common secondary sites such as the liver, lungs, brain, bones, or lymph nodes?"], "contexual_behavior": ["Can you see a lesion that appears functionally impaired, possibly due to nutrient deprivation in its microenvironment?", "Can you see a lesion that could be adapting to a low-oxygen environment by increasing glycolytic activity?", "Does the image show a lesion with reduced spread, possibly as a result of targeted therapy inhibiting oncogenic pathways?"], "functions": ["Can you see evidence of systemic effects, such as tissue wasting or features consistent with cachexia, that might be linked to a tumor?", "Can you see features that might indicate the spread of malignant cells through the bloodstream or lymphatic system?", "Can you identify signs of new blood vessel formation, such as angiogenesis, associated with an abnormal growth?"]}}, "metastatic carcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show abnormal tissue invading connective, muscle, epithelial, or nervous tissue?", "Can you identify lesions affecting organs such as the liver, lungs, bones, or brain?", "Is there evidence of abnormal cells utilizing lymphatic vessels or lymph nodes to reach distant sites?", "Does the image suggest a possible origin from tissues like breast, lung, colon, prostate, or skin?", "Can you see signs of disease spreading through the circulatory or lymphatic systems?", "Is there a structure that appears to facilitate the movement of abnormal cells, such as blood vessels, lymphatic vessels, or basement membrane disruption?", "Are there visible abnormalities in regions commonly targeted by secondary tumors, such as the liver, lungs, bones, brain, or lymph nodes?", "Does the image show abnormal cells interacting with or invading blood vessels or capillaries?", "Is there evidence of cells crossing anatomical barriers like the basement membrane, endothelial barriers, or the blood-brain barrier?", "Can you identify both a primary lesion and a separate secondary lesion, suggesting the spread of malignant cells from one site to another?"], "contexual_behavior": [], "functions": ["Does the image show evidence of abnormal cell clusters invading surrounding tissues?", "Can you identify areas where healthy tissue appears to be replaced or disrupted, potentially impairing organ function?", "Is there visual evidence of tissue structures being breached, such as the basement membrane or extracellular matrix?", "Does the image reveal signs of new blood vessel formation that could be stimulated by pro-angiogenic factors?", "Can you see regions where the local tissue environment appears altered, such as increased stromal cell presence or changes in matrix composition?", "Is there evidence of immune cell infiltration or inflammation, possibly due to cytokine release?", "Does the image display features suggestive of fibroblast activation or increased matrix metalloproteinase activity?", "Are there signs of abnormal cellular proliferation or expansion beyond normal tissue boundaries?", "Can you observe areas that might indicate hypoxia or nutrient competition, such as poorly vascularized or necrotic regions?", "Is there visual indication of organ dysfunction or structural compromise, such as distortion or loss of normal architecture?", "Does the image suggest the presence of cells that may be resisting apoptosis or exhibiting survival advantages?", "Can you identify features that could be associated with altered growth factor signaling or disrupted intercellular communication?", "Is there evidence of metastatic spread, such as abnormal cell clusters present in distant organs or tissues?", "Does the image show signs of cachexia or systemic metabolic effects, such as tissue wasting or loss of normal tissue mass?"]}, "no_questions": {"contexual_properties": ["Can you identify any signs of disruption in the continuity of the bones forming the floor of the cranial cavity?", "Is there a visible abnormality at the base of the cranial bones that could indicate trauma?", "Does the image show any evidence of a fracture involving the base of the skull?"], "properties": ["Can you estimate the length of a fracture at the skull base, and is it within the range of a few millimeters to several centimeters?", "Can you identify a linear, shallow break at the skull base with a width of only a few millimeters?", "Can you identify features that might indicate cerebrospinal fluid leakage associated with a fracture at the skull base?"], "relational": ["Does the image suggest possible involvement of nerves like the olfactory, optic, oculomotor, facial, vestibulocochlear, glossopharyngeal, vagus, accessory, or hypoglossal nerves?", "Is there a structure in the image that could put the central nervous system, auditory system, or vestibular system at risk?", "Does the image reveal any connection or communication between the skull base and spaces like the middle ear, nasal cavity, paranasal sinuses, or orbits?"], "contexual_behavior": ["Is there a visible disruption in the continuity of the bones forming the floor of the cranial cavity?", "Does the image show any evidence of a fracture involving the base of the skull?", "Can you identify any abnormalities at the base of the cranial bones that could indicate trauma?"], "functions": ["Is there visual evidence of a breach in the barrier between the brain and the external environment, potentially increasing susceptibility to pathogen entry?", "Can you see any indications of vascular injury at the skull base, such as hemorrhage or impaired venous drainage?", "Is there evidence of altered intracranial pressure regulation, possibly due to cerebrospinal fluid leakage or intracranial bleeding?"]}}, "siamese twins": {"yes_questions": {"contexual_properties": ["Does the image show individuals who share major body regions such as the thorax or abdomen, suggesting the presence of shared organs?", "Can you identify fused skeletal structures, such as at the spine, pelvis, or skull, indicating a connection between two bodies?", "Is there a noticeable difference in body size between two connected individuals that could be due to unequal blood supply or nutrient distribution?", "Do you observe unequal limb development or asymmetry in the limbs of two joined bodies, possibly resulting from disrupted morphogenesis or vascular anomalies?", "Is there evidence of abnormal skin connections, such as extensive soft tissue bridges or shared integument, between two individuals?", "Can you see signs that each individual has a separate circulatory system, such as the presence of independent cardiovascular structures?", "Are there differences in organ composition, where one individual appears to lack or have underdeveloped organs compared to the other?", "Is there an asymmetry in body weight, muscle mass, or fluid retention between the two connected bodies?", "Do you observe composite tissue structures or abnormal anatomical features at the site where the two bodies are joined?", "Are there visible differences in measurable vital signs, such as heart rate or respiratory rate, between the two individuals?", "Can you identify abnormal joint formations or fused joints between the two bodies, suggesting altered bone articulation?", "Is there evidence of shared blood flow or vascular connections that could indicate cross-circulation or hemodynamic changes between the individuals?", "Do you notice variations in organ size between the two bodies, such as one having larger or smaller organs?", "Are there differences in skin coloration, such as cyanosis or pallor, between the two connected individuals?", "Is there abnormal fluid accumulation, such as edema or seroma, in the areas where the two bodies are joined?"], "properties": ["Does the image show individuals with partially fused body parts or duplicated anatomical structures?", "Can you identify any shared organs or evidence of organ fusion between two individuals?", "Is there a visible connection between two bodies that could correspond to thoracic, abdominal, pelvic, or cranial regions?", "Do you observe any features suggesting a type of physical connection such as thoracopagus, omphalopagus, pygopagus, ischiopagus, or craniopagus?", "Is there evidence of shared blood vessels, such as hepatic or cardiac vessels, at the site where two bodies are joined?", "Can you estimate if the combined weight of the connected individuals might fall within the 4\u20137 kg range typical at birth?", "Does the total length of the connected bodies appear to be approximately 45 to 55 centimeters?", "Is the skin color of the individuals consistent with what would be expected for neonates of the same ethnic background?", "Can you observe four arms and four legs, or is there a different number of limbs present due to the type of fusion?", "Does the distribution of body mass between the two individuals appear symmetrical, or is there noticeable asymmetry?", "Is there any indication that most major organs are duplicated except at the site of union?", "Can you estimate if the head circumference of each individual is within the 33\u201336 cm range typical for neonates?", "Is there visual evidence suggesting that both individuals might have the same blood type, as would be expected from identical genetic origin?", "Do the individuals appear to be genetically identical, as suggested by similar physical features?", "Is there any sign that vital signs or Apgar scores might be affected by shared physiology or complications due to fusion?"], "relational": ["Does the image show individuals who share anatomical structures such as skin or muscles?", "Can you identify a case where organs like the liver or heart appear to be joined between two bodies?", "Is there evidence of a connection involving organ systems such as the digestive or circulatory system between two people?", "Does the image display fusion at body regions like the thorax, abdomen, pelvis, or head?", "Can you see tissues such as epithelial or muscle tissue forming a bridge between two individuals?", "Is there a visible indication of shared blood vessels or cross-circulation between two bodies?", "Does the image show skeletal structures, like the sternum or skull, that appear fused between two persons?", "Can you observe a shared body cavity, such as the thoracic or abdominal cavity, between two individuals?", "Is there evidence that the fusion occurs along a specific anatomical plane, such as sagittal or coronal?", "Does the image show two bodies attached at points like the chest, abdomen, pelvis, head, or back?"], "contexual_behavior": [], "functions": ["Does the image show individuals who might be experiencing organ sharing?", "Can you identify any anatomical connections that could lead to circulatory complications?", "Is there evidence of shared blood vessels or cross-circulation between two bodies?", "Does the image suggest a scenario where partial organ function or shared physiological processes might occur?", "Can you see signs of functional dependency between two anatomically connected individuals?", "Is there visual indication of reduced organ capacity or potential for functional overload due to shared organs?", "Does the image depict a situation that could increase surgical risk because of anatomical connections?", "Can you observe features that would require neuromuscular adaptation or cooperative motor control between two people?", "Is there evidence of compensatory mechanisms for coordinated movement in anatomically connected individuals?", "Does the image suggest the possibility of crossed sensory input or shared motor output due to shared neural structures?", "Can you see anatomical features that might lead to complex neural integration between two individuals?", "Is there a scenario where altered metabolic rates or nutrient sharing could be a concern?", "Does the image indicate a risk of metabolic imbalance due to shared organs?", "Can you identify features that might increase susceptibility to infection or suggest immune tolerance between two connected bodies?", "Is there evidence of chimerism or shared tissues that could affect immune responses?", "Does the image show a situation where shared digestion or coordinated feeding might be necessary?", "Can you observe anatomical connections that could result in risk of malabsorption or digestive complications?", "Is there visual evidence of shared reproductive organs that could lead to altered fertility or complex sexual development?", "Does the image suggest the presence of organ redundancy or shared feedback mechanisms for homeostasis regulation?", "Can you see features indicating combined filtration or shared urinary output in the excretory system?", "Is there evidence of risk for renal overload due to shared kidneys or bladder?", "Does the image suggest reduced respiratory capacity or shared ventilation between two anatomically connected individuals?", "Can you identify features that might increase the risk of respiratory compromise due to shared lungs or airways?"]}, "no_questions": {"contexual_properties": ["Can you see increased fibril formation or growth, possibly due to enhanced amyloidogenic processing or seeding events?", "Can you identify areas where protein aggregates are larger, suggesting advanced stages of pathology or persistent misfolding?", "Can you observe structural differences in aggregates that might be explained by genetic mutations, post-translational modifications, or environmental influences?"], "properties": [], "relational": ["Is there evidence of involvement of cell types like neurons, astrocytes, microglia, or endothelial cells?", "Does the image reveal alterations in neural, glial, or vascular tissue?", "Is there evidence of involvement of perivascular pathways, the glymphatic system, or white matter tracts?"], "contexual_behavior": [], "functions": ["Can you observe signs that may correlate with cognitive impairment, such as memory loss or learning deficits?", "Are there features consistent with disrupted neuronal signaling or synapse loss?", "Does the image display amyloid plaques, tissue damage, or loss of neural integrity in the brain?"]}}, "multiple lytic lesions": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show areas within bone that appear as well-defined radiolucent regions?", "Can you identify multiple regions of decreased density compared to normal bone tissue?", "Are there two or more lesions visible, possibly numbering in the dozens, within the skeletal structures?", "Do any of the lesions range in size from a few millimeters to several centimeters in diameter?", "Are the shapes of the observed lesions round, oval, or irregular?", "Can you see lesions with margins that are either well-defined or ill-defined?", "Are there radiolucent areas located in the axial skeleton, such as the spine, pelvis, or ribs, or in long bones?", "Is there evidence of cortical thinning, expansion, or breakthrough in the affected bone regions?", "Do the lesions have an average volume that could be estimated between 0.5 and 10 cubic centimeters?", "On MRI images, do any bone lesions show low signal intensity on T1-weighted images and high signal intensity on T2-weighted images?", "On CT scans, are there areas within bone that demonstrate low attenuation relative to the surrounding bone?", "Is there a visible reduction in mineral content or signs of osteopenia in certain bone regions?", "Are the borders of any lesions sharp, ragged, or moth-eaten in appearance?", "Do the lesions lack visible matrix mineralization?", "Is the pattern of bone destruction in the image geographic, permeative, or moth-eaten in nature?"], "relational": ["Does the image show evidence of abnormalities affecting the skeletal or hematopoietic systems?", "Can you identify areas of bone destruction within the vertebrae, pelvis, ribs, skull, or femur?", "Is there any indication of lesions located in the axial skeleton, proximal long bones, or pelvic girdle?", "Do you observe changes involving bone marrow, periosteum, or adjacent soft tissue near abnormal bone regions?", "Are there visible disruptions in the cortex, trabecular bone, or medullary cavity associated with any bone lesions?", "Can you detect features that might suggest the presence of malignant plasma cells, osteoclasts, or inflammatory cells within bone abnormalities?", "Is there visual evidence of bone loss or structural weakness in any part of the skeletal system?", "Do you see signs of pathological fractures, soft tissue masses, or sclerotic lesions near areas of bone destruction?", "Are there indications of medullary spread, cortical breach, or extension of lesions to adjacent bones?", "Does the image suggest a pathological process such as metastatic disease, multiple myeloma, or a bone resorption disorder?"], "contexual_behavior": ["Does the image show areas of bone that could indicate increased resorption, as might be seen when tumor cells stimulate osteoclast activity in metastatic cancer?", "Can you identify regions where bone strength appears compromised, potentially due to disruption of the bone matrix as in multiple myeloma?", "Are there signs of accelerated bone destruction that could be associated with elevated parathyroid hormone levels, as seen in hyperparathyroidism?", "Does the image reveal regions of reduced bone mineral density that might result from chronic inflammation and increased bone turnover?", "Are there bone defects that appear unhealed, possibly due to ongoing inflammation and impaired regeneration?", "Can you observe evidence of disrupted bone remodeling, where bone resorption seems to exceed formation, as in osteoporosis?", "Is there visual indication of extensive bone matrix degradation that could lead to increased calcium release into the bloodstream, as in hypercalcemia?", "Does the image suggest impaired bone repair capacity following trauma, where regeneration appears limited due to ongoing destructive processes?", "Are there bone lesions that seem more extensive or rapidly progressing, which could be consistent with an immunocompromised state?", "Can you see areas where the mechanical support or structural integrity of bone is compromised by significant bone loss?", "Does the image show evidence of marrow involvement, where destructive lesions may be replacing or infiltrating bone marrow spaces and potentially impairing hematopoiesis?", "Are there bone lesions that appear persistent despite possible therapy, suggesting reduced response to osteoclast-inhibiting treatments such as bisphosphonates?", "Is there visual evidence of weakened bone that could increase the risk of pathological fractures during physical activity?", "Can you identify signs of lesion regression or slowed progression, which might indicate a response to successful cancer treatment?", "Does the image suggest that the behavior or appearance of bone lesions could be influenced by hormonal imbalances, as seen in endocrine disorders affecting bone metabolism?"], "functions": ["Does the image show areas of bone destruction that could lead to decreased bone mass or instability?", "Can you identify regions within the skeleton where bone structure appears weakened or defective?", "Is there evidence of bone abnormalities that might increase the risk of fractures?", "Does the image reveal features suggesting impaired skeletal stability or loss of load-bearing capacity?", "Are there signs of bone changes that could disrupt calcium homeostasis, such as increased bone resorption?", "Can you see bone alterations that might be associated with elevated serum calcium levels?", "Is there visual evidence of cortical thinning or microfractures that could contribute to bone pain?", "Do you observe any skeletal features that indicate susceptibility to pathological fractures?", "Are there patterns in the bone that suggest excessive osteoclastic activity or disrupted remodeling?", "Does the image show bone changes that could lead to the release of calcium or alkaline phosphatase into the bloodstream?", "Can you identify regions where normal bone marrow may be replaced, potentially suppressing blood cell production?", "Is there evidence of skeletal deformity or collapse that would diminish structural support?", "Do the bone findings suggest possible impairment of mobility or physical function?", "Are there indications that the bone's ability to repair damage is compromised, such as persistent defects or remodeling deficits?"]}, "no_questions": {"contexual_properties": ["Does the image show deformation of a bone structure, possibly following trauma, congenital skull abnormality, or neoplastic growth?", "Does the image reveal changes in bone density that might be related to metabolic disorders, neoplastic processes, or trauma?", "Can you identify loss of structural integrity in a bone, as might be seen in severe osteoporosis, extensive lytic lesions, or advanced infection?"], "properties": ["Does the image reveal tightly packed osteons and lamellae characteristic of cortical bone organization?", "Is there evidence of a bone layer with low porosity, typically less than 10%?", "Can you see a structure that appears flat or gently curved, following the contour of the cranial vault?"], "relational": ["Does the image display the three-layered organization of cranial bone, including a layer between the diplo\u00eb and the cranial cavity?", "Can you see a layer that is in contact with the dura mater or other meningeal tissues?", "Is there a structure contributing to the architecture of the cranial vault?"], "contexual_behavior": ["Is there a part of the cranial bone that could show altered resistance to pressure, possibly due to metabolic bone disorders such as hyperparathyroidism or rickets?", "Can you observe any indication of active bone remodeling or changes consistent with skull growth or healing after cranial injury?", "Is there a bony layer whose barrier function might be compromised due to infection or inflammation?"], "functions": ["Can you see a protective layer situated between neural tissue and the outer skull that might shield against trauma?", "Can you identify a region of cranial bone that appears to add rigidity and resistance to deformation?", "Does the image contain a structure that reinforces the inner aspect of the skull to help prevent fractures?"]}}, "skull": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with an oval or rounded shape and a slightly elongated anteroposterior axis?", "Can you identify an object that appears off-white or pale ivory due to mineralized bone tissue?", "Is there a structure present that could measure approximately 22 cm in length, 17 cm in width, and 14 cm in height?", "Does the image contain an object whose thickness varies between 4 and 8 millimeters depending on the region?", "Can you see a structure that might weigh between 1.3 and 1.5 kilograms in adults?", "Is there an object composed primarily of compact and spongy bone, collagen fibers, hydroxyapatite, and water?", "Does the image include a structure made up of 22 bones, with both cranial and facial components?", "Can you identify an object with a moderate porosity, especially in regions containing spongy bone?", "Is there a structure whose surface appears mostly smooth but with some roughened areas for muscle attachment?", "Does the image show an object with a circumference of about 55 to 58 centimeters?", "Can you see a structure that might have a bone density ranging from 1.5 to 2.0 g/cm\u00b3?", "Is there an object whose water content is approximately 10% by weight?", "Does the image contain a structure with a mineral content mainly consisting of hydroxyapatite, accounting for about 65% of its dry weight?", "Can you identify an object with a calcium concentration of about 20\u201325% and a phosphorus concentration of roughly 10\u201312% of its total weight?", "Is there a structure with a collagen content of about 20\u201325% of its organic matrix?", "Does the image show an object with a typical hardness of around 5 on the Mohs scale?", "Can you see a structure whose cranial cavity volume could be approximately 1350 to 1500 milliliters?"], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify any bones such as the frontal, parietal, or temporal bones?", "Is there a region visible that could correspond to the cranium or facial skeleton?", "Does the image display features like the calvaria or cranial base?", "Can you see any joints such as cranial sutures or the temporomandibular joint?", "Is there evidence of cavities like the cranial, nasal, or orbital cavities?", "Does the image include a structure that protects the brain or eyes?", "Can you identify an articulation point with the vertebral column, such as the foramen magnum?", "Is there a visible area where muscles like the temporalis or masseter might attach?", "Can you see any foramina, such as the optic canal or jugular foramen?", "Are there distinguishing features such as multiple cavities or complex articulations present?", "Does the image show a structure involved in protecting the inner ear or nasal passages?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides protection for the brain?", "Can you identify a rigid bony cavity that encapsulates neural tissue?", "Does the image show a framework that supports sensory organs such as the eyes or ears?", "Is there a visible structure forming orbital or nasal cavities?", "Can you see attachment points for muscles involved in chewing?", "Does the image include features like the mandible or maxilla that enable mastication?", "Is there a bony framework shaping the forehead, cheeks, or jaw?", "Can you identify surfaces or ridges for the attachment of facial muscles responsible for expression?", "Does the image show structures forming the oral or nasal cavities, which facilitate speech resonance?", "Is there evidence of air-filled cavities that could contribute to sound resonance?", "Can you see anatomical features that protect the entrances to the respiratory or digestive tracts?", "Is there a structure maintaining a closed cavity that could help regulate intracranial pressure?"]}, "no_questions": {"contexual_properties": ["Can you identify any discoloration that could be caused by hematoma, infection, or vascular compromise?", "Is there an indentation that might result from pressure, tissue loss, or scarring?", "Are there signs such as redness, warmth, swelling, or pus that might indicate infection?"], "properties": ["Does the image display a surface that would be expected to have a pH between 6.8 and 7.4?", "Is there a region that likely contains 60\u201380% water content, as seen in soft tissues?", "Can you see an area composed of epithelial tissue, connective tissue, or muscle fibers?"], "relational": ["Does the image depict regions separated by a midsagittal or parasagittal plane?", "Are there lymphatic structures arranged according to the sides of the body?", "Are there lateral anatomical features that distinguish the left from the right in the image?"], "contexual_behavior": ["Is there any indication of trauma disrupting the thoracic or abdominal wall, potentially reducing protection for internal organs on one side?", "Does the image show increased muscular activity or compensatory movement on one lateral aspect, possibly due to weakness or injury on the opposite side?", "Is there a visible rib fracture or discontinuity in the rib cage that could impair force transmission along one lateral region?"], "functions": ["Does the image show a lateral region that separates the front and back aspects of the body?", "Can you identify attachment points for muscles like the latissimus dorsi or serratus anterior involved in movement coordination?", "Does the image include a part of the rib cage or muscular wall that helps protect internal organs such as the lungs or liver?"]}}, "myoma lesion": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure associated with the female reproductive system?", "Is there a lesion involving smooth muscle or connective tissue visible in the image?", "Can you identify an abnormality located in the uterus or cervix?", "Does the image display a mass adjacent to the endometrium, myometrium, or serosa?", "Is there a lesion present within the submucosal, intramural, or subserosal layers of the uterus?", "Can you see a structure that appears to receive blood supply from the uterine or ovarian artery?", "Is there evidence of an abnormality altering the structure of the uterine wall?", "Does the image contain a mass composed of smooth muscle cells or fibroblasts?", "Is there a lesion affecting the uterine corpus or fundus?", "Can you observe any displacement or compression of the bladder, rectum, or uterine cavity by a mass?"], "contexual_behavior": ["Does the image show a lesion whose growth rate might be higher during the reproductive years and lower after menopause?", "Is there a structure present that could impair uterine contractility during menstruation by interfering with myometrial function?", "Can you identify a lesion that may alter its vascularization or show increased angiogenesis during pregnancy?", "Does the image contain a mass that could decrease in metabolic activity following hormonal therapy with GnRH agonists?", "Is there evidence of a structure that might increase extracellular matrix production in response to estrogen stimulation?", "Can you see a lesion that could distort the uterine cavity and disrupt normal endometrial function during the menstrual cycle?", "Is there a mass that may reduce its ability to promote angiogenesis after menopause due to lower estrogen levels?", "Does the image show a lesion that could increase inflammatory signaling and local cytokine release during tissue injury or degeneration?", "Can you identify a structure that might impair fertility by altering the uterine environment or distorting the endometrial cavity?", "Is there a lesion that could increase its secretion of growth factors in response to progesterone, supporting cellular proliferation?", "Does the image show a mass whose proliferation might be reduced after treatment with GnRH agonists?", "Can you see a lesion that could alter uterine blood flow during pregnancy due to increased vascular demand and hormonal changes?", "Is there evidence of a structure that might increase fibrotic activity and collagen deposition under chronic inflammation?", "Does the image contain a lesion whose functional impact could decrease after surgical intervention such as myomectomy or ablation?"], "functions": ["Does the image show a benign growth within the uterus that could disrupt normal smooth muscle architecture?", "Is there evidence of a uterine mass that might impair contractility of the uterine wall?", "Can you identify a lesion that could be responsible for abnormal or heavy menstrual bleeding?", "Does the image contain a structure that might distort the uterine cavity and potentially interfere with embryo implantation?", "Is there a mass present that could alter the uterus's responsiveness to estrogen or progesterone?", "Can you see a lesion that might cause pelvic pain or exert pressure on nearby pelvic organs?", "Is there a structure that could disrupt normal endometrial function or cause local inflammation?", "Does the image show a mass that might affect the vascular supply of the uterus, such as by compressing blood vessels or promoting abnormal angiogenesis?", "Can you identify a lesion interacting with adjacent uterine tissues by compressing or displacing the myometrium or endometrium?", "Is there evidence of abnormal uterine growth due to proliferation of smooth muscle cells and extracellular matrix?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the tissue appear pink to light purple under hematoxylin and eosin staining?", "Is the Ki-67 index low to intermediate, typically below 20%, in the tumor sample?", "Can you see evidence of positive or moderately expressed progesterone receptor in the tissue?"], "relational": ["Is there a lesion present in tissue that is responsive to estrogen signaling?", "Does the image reveal cells with features of luminal epithelial cells that may express hormone receptors?", "Is there a tumor located near structures such as the chest wall, axillary lymph nodes, or surrounded by adipose tissue?"], "contexual_behavior": [], "functions": ["Does the image suggest a neoplasm that could respond to therapies targeting estrogen signaling, such as tamoxifen or aromatase inhibitors?", "Does the image suggest altered gene expression patterns that could be regulated by hormone receptor activity?", "Can you see signs of cell cycle regulation that might be influenced by hormone receptor activity?"]}}, "skull cap": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that forms part of the cranium?", "Can you identify bones such as the frontal, parietal, or occipital within the image?", "Is there a region adjacent to the scalp or temporal area visible?", "Does the image display connections between bones that could represent coronal, sagittal, or lambdoid sutures?", "Can you see a surface covered by tissues like periosteum or skin?", "Is there a structure that encloses a cavity for the brain?", "Does the image show a boundary forming the uppermost part of the cranial cavity?", "Are there features suggesting the presence of meninges or blood vessels beneath a bony surface?", "Can you identify membranes such as dura mater, arachnoid mater, or pia mater lining the inner surface of a structure?", "Is there evidence of protection for superior brain structures or the cerebrum in the image?"], "contexual_behavior": ["Is there evidence of a cranial structure with fractures or defects that could reduce brain protection during trauma?", "Does the image show signs of bone density loss or increased brittleness that might indicate decreased impact absorption with age?", "Can you identify areas of bone thinning or reduced mineral content that could suggest osteoporosis affecting cranial protection?", "Are there visible features consistent with congenital defects, such as abnormal bone formation or early suture closure, that might compromise cranial shielding?", "Does the cranial region appear to facilitate increased heat dissipation, possibly in response to fever?", "Is there any indication of disrupted bone integrity due to infection or inflammation, such as changes seen in osteomyelitis?", "Can you observe impaired healing or poor vascular supply in the cranial bones following a fracture?", "Are there structural changes in the cranial region that could be attributed to metabolic bone diseases like rickets or Paget\u2019s disease?", "Does the image reveal localized thinning or remodeling of cranial bones that might result from chronic pressure?", "Are there signs of impaired bone mineralization, such as decreased resistance to penetration, that could be linked to vitamin D deficiency?", "Is there evidence of a depressed fracture or loss of bone continuity that could affect the maintenance of intracranial pressure after injury?", "Can you see alterations in cranial bone structure that might result from surgical removal or repositioning of bone flaps?", "Does the cranial region display features of age-related bone thinning or decreased elasticity, particularly in elderly individuals?", "Are there visual cues of compromised bone matrix or reduced strength in the cranial bones that could be associated with malnutrition?", "Does the image suggest that the cranial structure is serving as a primary barrier against external forces, especially in the context of high-risk activities?"], "functions": ["Does the image show a structure that provides a rigid barrier shielding the brain from external trauma?", "Is there a bony enclosure that helps maintain the shape and stability of the upper portion of the head?", "Can you identify a feature that serves as a protective enclosure for sensory organs such as the eyes and ears?", "Does the image contain a curved bone that could absorb and distribute mechanical forces from impacts?", "Is there a surface present that offers attachment sites for scalp muscles involved in movement and expression?", "Can you see a structure that encloses and safeguards the brain and meninges from external harm?", "Is there evidence of a rigid enclosure that helps maintain intracranial pressure by housing the brain and cerebrospinal fluid?", "Does the image include a bony structure that protects blood vessels within the cranial cavity by encasing them?", "Can you identify a feature that provides structural support to the head and helps prevent brain injury?", "Is there a visible component that contributes to the dissipation of mechanical forces across its curved surface to minimize localized damage?"]}, "no_questions": {"contexual_properties": ["Does any of the fluid have a greenish hue, possibly due to infection with bacteria such as Pseudomonas aeruginosa?", "Can you detect any area where the fluid has a foul odor, possibly indicating anaerobic bacterial infection?", "Is there evidence of increased fluid accumulation at a site of acute inflammation or infection?"], "properties": ["Is there a fluid that might have a higher albumin concentration than transudate?", "Can you identify a material that could have an elevated white blood cell count, possibly exceeding 1,000 cells/\u03bcL?", "Can you identify any material that looks cloudy, turbid, or purulent?"], "relational": ["Is there a region where lymphatic vessels or lymph nodes might be involved in draining or clearing excess fluid?", "Does the image show evidence of fluid accumulation in areas such as the pleural cavity, peritoneal cavity, joint spaces, or alveoli?", "Can you identify a region where connective, epithelial, or endothelial tissue appears to be undergoing inflammation or injury?"], "contexual_behavior": ["Does the image reveal accelerated fluid accumulation and leukocyte migration that could be associated with tissue injury?", "Is there evidence of excessive or persistent fluid that might impair tissue healing, especially in the context of an immunocompromised state?", "Is there visible swelling or edema that could be attributed to increased hydrostatic pressure, as seen in congestive heart failure?"], "functions": ["Can you identify an area where increased fluid volume could be diluting toxins at a site of inflammation?", "Is there a visible accumulation that might be delivering plasma proteins or leukocytes to affected tissues?", "Can you see a fluid that might be flushing microorganisms out of tissue or supporting phagocytosis?"]}}, "x-ray": {"yes_questions": {"contexual_properties": ["Does the image display increased opacity that could indicate accumulation of fluid, infection, or a mass in a particular area?", "Is there evidence of decreased density that might suggest loss of normal tissue mass, as seen in conditions like emphysema or osteoporosis?", "Can you identify abnormal shadows that could be due to tumors, infiltrates, or the presence of a foreign body?", "Does the image reveal any enlarged organs, such as an increased heart or liver size, which might indicate organomegaly?", "Is there visible thinning of bone structures that could be consistent with decreased bone mineral content?", "Can you see signs of fluid accumulation in spaces like the pleura or abdomen?", "Does the image show any areas of calcification that might result from chronic inflammation or metabolic disorders?", "Is there evidence of tissue swelling, such as increased soft tissue volume from inflammation, trauma, or infection?", "Can you detect loss of normal anatomical structure that could be due to destruction or distortion from trauma, infection, or malignancy?", "Does the image reveal any disruptions in bone continuity that might indicate a fracture?", "Are there abnormal air patterns present, such as air outside normal anatomical locations?", "Can you observe changes in lung volume, such as hyperinflation or collapse, that might be related to diseases like COPD or atelectasis?", "Is there narrowing of joint spaces that could suggest degenerative or inflammatory joint disease?", "Does the image show any abnormal soft tissue or bone growths that might represent a mass or tumor?", "Can you identify areas of bone overgrowth, such as excessive bone formation or osteophytes?", "Is there abnormal alignment of bones or joints, such as displacement or angulation, visible in the image?", "Does the image display changes in bone density that could be associated with metabolic or neoplastic bone diseases?", "Is there evidence of soft tissue thickening that might result from inflammation, infection, or neoplastic infiltration?", "Can you see an abnormal heart size that could indicate cardiac enlargement?", "Does the image reveal loss of bone structure that could be due to infection, malignancy, or severe trauma?"], "properties": ["Does the image display features that could be produced by electromagnetic radiation with a wavelength between 0.01 and 10 nanometers?", "Is there evidence of imaging that relies on photon energies in the range of 1 to 150 kiloelectronvolts?", "Can you identify visual characteristics that suggest the use of electromagnetic waves with frequencies between 3 \u00d7 10^16 and 3 \u00d7 10^19 hertz?", "Does the image show structures that would require penetration depths of 1 to 10 centimeters in soft tissue?", "Are there visual differences that could be explained by an attenuation coefficient of 0.2 to 0.5 per centimeter in bone?", "Is the image quality consistent with an intensity of 10^4 to 10^6 photons per square millimeter per second?", "Does the visual appearance suggest a radiation dose in the range of 0.01 to 0.1 millisieverts?", "Can you infer that the exposure duration for this image was between 1 and 500 milliseconds?", "Is the spatial resolution of the image within the range of 0.1 to 0.5 millimeters?", "Does the image exhibit contrast levels that could result from a 1% to 5% difference in tissue density?", "Is the grayscale range of the image consistent with 8 to 16 bits per pixel?", "Can you deduce that the photon flux used to create this image was between 10^12 and 10^15 photons per second?", "Does the image field appear to have a width between 0.5 and 2 millimeters for the beam used?", "Is the field size of the image within the range of 18 \u00d7 24 centimeters to 35 \u00d7 43 centimeters?", "Does the image suggest that the energy spectrum of the beam was continuous from 20 to 150 kiloelectronvolts?", "Can you infer that the voltage used to generate the image was between 40 and 150 kilovolts peak?", "Is there evidence that the current used in the imaging process was between 1 and 500 milliamperes?", "Does the image display a noise level that could be between 1% and 10% of the signal?", "Is the film sensitivity implied by the image quality within the 100 to 400 speed index range?"], "relational": ["Does the image allow visualization of structures such as bones or joints?", "Can you identify regions like the chest, abdomen, or limbs being examined?", "Is there evidence of tissues with varying densities, such as bone, air-filled spaces, or soft tissue?", "Does the image provide information about the skeletal, respiratory, or cardiovascular systems?", "Can you assess bone alignment or joint spaces in the image?", "Is there a visible structure that could be the femur, tibia, or spine?", "Can you see organs such as the lungs or heart in the image?", "Is the position of the trachea or diaphragm discernible?", "Does the image reveal any signs of fractures, dislocations, or calcifications?", "Can you identify anatomical planes such as lateral or anteroposterior views?", "Is there a body part, such as the hand, foot, or pelvis, positioned specifically for examination?", "Can you detect any abnormalities like tumors or infections in the visible structures?", "Does the image show the relationship between bones and surrounding soft tissues?", "Is it possible to evaluate organ position within the thoracic or abdominal cavity?", "Can you distinguish fat from other soft tissues in the image?"], "contexual_behavior": ["Does the image suggest reduced diagnostic effectiveness in the presence of increased tissue thickness, such as in obese individuals?", "Can you determine if the image provides primarily structural rather than functional information, especially in the context of acute inflammation?", "Is there evidence that the detection of bone fractures in the image would not be improved by the use of a contrast agent?", "Does the image appear to have difficulty revealing soft tissue abnormalities that might be present in early stages of disease?", "Can you identify pulmonary changes, such as consolidation or infiltrates, that would become more apparent in the setting of pneumonia?", "Is there a reduction in the ability to detect tumors when dense tissue or overlapping structures are present in the image?", "Does the image suggest potential impairment of cellular function in radiosensitive tissues if the radiation dose is high?", "Can you observe any artifacts or obscured anatomical details that might be caused by the presence of metallic implants?", "Is there altered visualization of organs that could be related to physiological changes during pregnancy or efforts to minimize fetal radiation exposure?", "Does the image show signs that could result from repeated exposure, such as increased DNA damage or impaired DNA repair mechanisms?", "Is there enhanced detection of radiopaque calcifications that might be associated with chronic kidney disease?", "Does the image make it difficult to distinguish between acute and chronic bone infections due to similar radiographic features?", "Is the reliability of the image reduced by increased soft tissue density, as might occur in severe edema?", "Can you see improved visualization of lung fields that could result from deep inspiration and increased air volume?", "Does the image have limited diagnostic value for detecting early-stage osteoarthritis due to the invisibility of initial cartilage loss?"], "functions": ["Does the image provide visual information that could assist in diagnosing internal body structures?", "Can you identify any discontinuities or abnormal alignments in bones that might indicate a fracture?", "Is there evidence of abnormalities in the lungs, such as infiltrates, masses, or fluid accumulation?", "Does the image allow for comparison with previous images to monitor changes in anatomical structures over time?", "Can you see features that would help guide a medical procedure, such as the placement of a catheter or orthopedic hardware?", "Are there visible signs of dental issues, such as cavities, tooth decay, or bone loss in the jaw or teeth?", "Is there an abnormal mass, lesion, or calcification present that could suggest malignancy?", "Can you assess the alignment of bones, joint spaces, or signs of degeneration in joints or the spine?", "Are there any indications of chest abnormalities, such as pneumonia, pleural effusion, or enlargement of the heart?", "Is there a radiopaque object visible that could represent a foreign body within tissues or organs?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of a lesion affecting the mammary ducts or lobules?", "Does the image reveal any enlargement or involvement of axillary lymph nodes?", "Is there visible abnormality in the supraclavicular or internal mammary lymph nodes?"], "contexual_behavior": [], "functions": ["Can you identify an area with evidence of uncontrolled cell proliferation or abnormal growth patterns?", "Is there a region where fibroblast activation or changes in the tumor microenvironment are apparent?", "Is there visual evidence of abnormal cell clusters that could be resisting programmed cell death?"]}}}
[ { "answer": "lobular carcinomas", "extracted_concepts": [ "little stromal response", "noncohesive tumor cells", "linear cords of cells", "lobular carcinomas" ], "question": "what are composed of noncohesive tumor cells that invade as linear cords of cells and induce little stromal response?" }, { "answer": "noncohesive tumor cells that invade as linear cords of cells and induce little stromal response", "extracted_concepts": [ "linear cords of cells", "stromal response", "noncohesive tumor cells", "lobular carcinomas" ], "question": "what are lobular carcinomas composed of?" }, { "answer": "yes", "extracted_concepts": [ "linear cords of cells", "stromal response", "noncohesive tumor cells", "lobular carcinomas" ], "question": "are lobular carcinomas composed of noncohesive tumor cells that invade as linear cords of cells and induce little stromal response?" }, { "answer": "no", "extracted_concepts": [ "linear cords of cells", "stromal response", "noncohesive tumor cells", "normal marrow cells" ], "question": "are normal marrow cells composed of noncohesive tumor cells that invade as linear cords of cells and induce little stromal response?" } ]	["lobular carcinomas", "stromal response", "normal marrow cells", "little stromal response", "noncohesive tumor cells", "linear cords of cells"]	{"lobular carcinomas": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show an abnormality originating from the epithelial tissue of mammary lobules?", "Is there a lesion adjacent to breast stroma or adipose tissue?", "Can you identify a pathological structure associated with the mammary gland system?", "Is there evidence of a process affecting any region of the breast, such as the upper outer quadrant or central area?", "Does the image reveal changes involving lobular epithelial cells?", "Is there a mass structurally related to mammary lobules or terminal ducts?", "Can you see involvement of lymphatic structures like axillary or internal mammary lymph nodes?", "Is there a lesion with boundaries defined by breast lobule margins, surrounding stroma, or basement membrane?", "Does the abnormality reside within a larger structure such as the breast or mammary gland?", "Is there a pathological interaction with lactiferous ducts, Cooper\u2019s ligaments, or the nipple-areolar complex?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Can you identify a pattern where cortisol levels are highest in the early morning and lowest at night?", "Is there evidence of blood glucose levels rising after meals and decreasing during fasting intervals over a 24-hour span?", "Is there any indication of minimal fluctuations in oxygen saturation, with possible decreases during sleep or hypoventilation, across a 24-hour period?"], "properties": ["Does the image contain a representation of a time span equal to 86,400 seconds?", "Is there an indication of a period equivalent to 1 day?", "Does the image include a value of 86,400,000,000,000 nanoseconds?"], "relational": ["Can you see anatomical features involved in the regulation of body temperature or metabolic processes over a 24-hour period?", "Is there a visible structure that could be part of the central nervous system's circadian regulation?", "Can you identify a structure involved in the sleep-wake cycle?"], "contexual_behavior": ["Can you identify features related to the regulation of the sleep-wake cycle and its impact on physiological processes?", "Can you observe any indications of immune system activity that might be heightened during nighttime sleep?", "Does the image suggest changes in stress hormone levels, such as a peak in cortisol secretion in the early morning?"], "functions": ["Is there a depiction of metabolic activity, such as glucose or lipid processing, that might vary depending on the time of day?", "Can you identify any visual cues indicating fluctuations in hormone levels like melatonin or cortisol that are controlled by a biological clock?", "Can you observe cardiovascular features, like heart rate or blood pressure, that might reflect daily rhythmic changes?"]}}, "normal marrow cells": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show cellular components of the hematopoietic system?", "Can you identify cells located within bone marrow tissue?", "Are there visible cell types such as hematopoietic stem cells, progenitor cells, or stromal cells?", "Is there evidence of cells residing in the medullary cavities of bones?", "Does the image contain structures that give rise to erythrocytes, leukocytes, or platelets?", "Can you see cells that interact with the spleen, liver, or thymus during blood formation?", "Are there cells present that are part of the broader population of bone marrow cells?", "Does the image include bone regions such as the pelvis, vertebrae, ribs, or sternum containing cellular material?", "Can you identify cells contributing to blood cell production for the circulatory system?"], "contexual_behavior": [], "functions": ["Does the image show structures responsible for generating all types of blood cells?", "Can you identify cells that support hematopoiesis within the bone marrow microenvironment?", "Is there evidence of differentiation into erythroid, myeloid, or lymphoid lineages?", "Does the image contain progenitor cells or a supportive stroma for blood cell development?", "Can you see features associated with the production of lymphocytes or antigen-presenting cells involved in immune defense?", "Is there visual evidence of regulation of red and white blood cell production, possibly through feedback mechanisms?", "Are there cells present that give rise to megakaryocytes or contribute to platelet release?", "Can you identify signs of increased proliferation or differentiation of hematopoietic progenitors, as might occur after injury or blood loss?", "Does the image show a balance between self-renewal, differentiation, and apoptosis within the hematopoietic compartment?", "Are there features suggesting involvement in iron metabolism, such as support for erythropoiesis or iron recycling?", "Can you see evidence of cells expressing receptors for growth factors or cytokines, indicating responsiveness to these signals?", "Is there visual indication of stem cell activation or rapid hematopoietic recovery, as might occur after chemotherapy or radiation?", "Are there structures supporting macrophages involved in phagocytosis and clearance of senescent blood cells?", "Does the image show increased production of immune cells or features consistent with an inflammatory response to infection?"]}, "no_questions": {"contexual_properties": ["Can you detect cystic regions that might result from ductal obstruction, inflammation, or congenital anomalies?", "Does the structure display increased vascularity, which may be present in malignancy or acute inflammation?", "Is there a structure that might be associated with elevated PSA levels due to malignancy, inflammation, or hyperplasia?"], "properties": ["Can you identify a structure estimated to have between 30 and 50 glandular units?", "Is there a structure that would produce a fluid with a slightly acidic pH, around 6.4 to 7.0?", "Is there a structure whose volume would be around 20 to 30 milliliters in an adult male?"], "relational": ["Does the image contain an object adjacent to both the rectum and the seminal vesicles?", "Does the image show a structure that is part of the male reproductive system?", "Can you identify an organ composed of glandular tissue, fibromuscular stroma, and connective tissue?"], "contexual_behavior": ["Is there an organ that might increase its secretory activity in response to elevated androgen levels, such as during puberty or hormonal stimulation?", "Does the image show a structure whose ability to protect sperm might be reduced under inflammatory conditions?", "Does the image contain a structure whose function could become impaired after therapy that deprives it of androgens?"], "functions": ["Is there an object that produces secretions such as PSA, citric acid, or zinc to liquefy semen and protect sperm?", "Can you identify a gland that adds fluid to semen to enhance sperm motility and fertility?", "Does the image include a gland that interacts with seminal vesicles or bulbourethral glands to coordinate seminal fluid composition?"]}}, "little stromal response": {"yes_questions": {"contexual_properties": ["Does the image show a region where the tissue response is more pronounced in the context of tumor progression or active injury?", "Can you identify an area where the stromal component appears reduced in well-differentiated tumors or in regions with low inflammation?", "Is there evidence of altered cellular composition in the stroma during chronic inflammation or remodeling of the tumor microenvironment?", "Does the image display increased fibrosis in areas suggestive of persistent injury or fibrogenic signaling?", "Can you see regions with reduced collagen deposition, possibly indicating suppressed matrix synthesis or early-stage lesions?", "Is there a visible alteration in the extracellular matrix consistent with tissue remodeling or enzymatic degradation?", "Does the stroma show changes in density that could be associated with edema, cellular infiltration, or matrix breakdown?", "Can you identify areas where the stromal region appears more cellular, potentially due to active inflammation or stromal activation related to tumors?", "Is there a region where the stroma is less cellular, possibly reflecting quiescent tissue or resolution of inflammation?", "Does the image reveal increased numbers of inflammatory cells in the stroma, as might occur during acute injury or an immune response?", "Can you observe decreased vascularity in the stromal area, which could be due to hypoxic conditions or anti-angiogenic therapy?", "Are there regions where the staining characteristics of the stroma are altered, potentially due to changes in matrix composition or cellularity?", "Does the stroma appear more edematous, suggesting increased vascular permeability or lymphatic obstruction?", "Can you identify increased myofibroblast presence within the stroma, as might be seen during wound healing or fibrotic progression?", "Is there a visible change in stromal thickness that could be related to chronic irritation or tumor invasion?"], "properties": ["Does the image show an area with minimal proliferation of supporting tissue and scant fibrous material?", "Can you identify a region where the number of fibroblasts and other supporting cells appears low?", "Is there a part of the tissue with limited collagen deposition visible?", "Does the image contain an area with a small amount of extracellular matrix?", "Can you see a region where the density of fibroblasts is reduced compared to areas with more pronounced tissue reaction?", "Is there a zone with few or unremarkable new blood vessels present?", "Does the supporting tissue appear thin, without significant expansion beyond the baseline structure?", "On histological staining, is there an area where connective tissue components show weak or faint coloration?", "Can you identify a region with minimal infiltration by inflammatory cells?", "Is there a part of the tissue where the proportion of connective tissue is low relative to the overall area?"], "relational": ["Does the image show epithelial or tumor tissue with minimal surrounding connective tissue reaction?", "Can you identify carcinoma nests or malignant glands that lack a prominent fibrous response?", "Is there a region containing neoplastic epithelial cells with only sparse fibroblasts present?", "Does the image include tissue from the colon, breast, or prostate where the stroma appears limited?", "Are there areas where the proliferation or activation of connective tissue is minimal?", "Can you see regions in the gastrointestinal tract or mammary gland that exhibit little connective tissue around tumor cells?", "Is there evidence of invasive carcinoma foci or in situ tumor regions with scant stromal support?", "Does the image contain structures from the digestive or reproductive systems showing minimal fibrosis?", "Are there areas where the stromal response is less pronounced compared to a desmoplastic or inflammatory reaction?", "Can you identify regions where the extracellular matrix is composed mainly of collagen with limited fibronectin?"], "contexual_behavior": ["Does the image show evidence of impaired tissue repair after injury, such as minimal matrix production or poor healing?", "Is there a lack of fibrous capsule formation around malignant cells, suggesting poor containment of tumor growth?", "Can you observe reduced fibrosis in areas of chronic inflammation, indicating low stromal activity?", "Does the image reveal impaired angiogenesis during wound healing, possibly due to a deficiency in stromal-derived growth factors?", "Is there poor extracellular matrix deposition, as seen by insufficient structural protein synthesis in the tissue?", "Can you identify altered immune cell recruitment in regions of infection, potentially due to diminished chemokine or cytokine release?", "Does the tissue display inadequate scar formation, suggesting insufficient reparative stroma?", "Is there evidence of decreased resistance to invasive pathogens, such as weak or disrupted physical barriers?", "Can you see limited progression of fibrotic disease, possibly due to low levels of matrix accumulation?", "Does the image suggest impaired tissue remodeling after surgery, with suboptimal reorganization of the affected area?", "Is there decreased stromal support for epithelial regeneration, as indicated by a lack of matrix scaffolding or paracrine signaling?", "Can you observe fibroblast inactivity in response to injury, such as a lack of fibroblast recruitment or activation?", "Is there increased tumor cell dissemination or metastasis, possibly due to a weak or absent stromal barrier?", "Does the tissue show impaired formation of a protective barrier during chronic disease, with insufficient matrix or cellular components?", "Can you detect altered signaling or communication between stromal and parenchymal cells in the tissue?"], "functions": ["Does the image show tissue with minimal activation or proliferation of supporting cells, suggesting stromal inactivity?", "Is there evidence of impaired tissue repair, such as reduced fibroblast presence or limited extracellular matrix deposition?", "Can you identify a tumor area with limited fibrous tissue formation, indicating low desmoplasia?", "Does the tissue appear to have decreased infiltration of immune cells, possibly due to low chemokine or cytokine production?", "Is there a reduction in extracellular matrix synthesis or turnover, suggesting matrix stability rather than active remodeling?", "Does the image show diminished formation of new blood vessels, consistent with low angiogenesis?", "Is there a lack of granulation tissue or delayed closure in a wound, indicating poor healing?", "Can you observe a local environment with low levels of inflammation or reduced release of inflammatory mediators?", "Does the tissue display decreased paracrine or autocrine signaling between supporting and other cells, suggesting cellular quiescence?", "Is there minimal interaction or support between supporting tissue and epithelial cells, possibly indicating epithelial independence?"]}, "no_questions": {"contexual_properties": ["Can you see a vessel wall that seems less elastic, possibly due to aging or chronic vascular disease?", "Does the image show a vascular structure that might have increased pressure, as seen in left heart failure, chronic lung disease, or pulmonary embolism?", "Can you identify a blood vessel with a thickened wall, possibly due to chronic pressure overload or pulmonary arterial hypertension?"], "properties": ["Can you identify a cylindrical vessel with a slightly curved course?", "Is there a structure that would be expected to have a blood pH between 7.35 and 7.45?", "Does the image show a vessel that maintains a temperature close to 37 degrees Celsius?"], "relational": ["Can you identify a structure that consists of a trunk and branches leading to both the right and left sides?", "Is there a vessel that is directly connected to the right ventricle of the heart?", "Does the image contain a vessel that is part of the cardiovascular system and involved in pulmonary circulation?"], "contexual_behavior": ["Is there a vessel that would show increased pressure during exercise as a result of elevated blood flow?", "Does the image show a vessel whose function could improve after removal of an obstruction, restoring normal blood flow?", "Is there evidence of a vessel that could experience impaired pressure regulation due to increased vascular resistance and thickening of its wall?"], "functions": ["Does the image include a conduit responsible for transporting blood to the lungs for oxygen absorption?", "Can you identify a structure that branches to deliver blood to both lungs?", "Is there a vessel present that enables gas exchange by supplying blood to pulmonary capillaries?"]}}, "noncohesive tumor cells": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show cells within epithelial, connective, or lymphatic tissues that appear individually dispersed rather than clustered?", "Can you identify a region where there is a loss of intercellular adhesion, with cells infiltrating as single units rather than forming cohesive groups?", "Is there evidence of a scattered growth pattern or single-cell infiltration in tissues commonly affected by lobular carcinoma or diffuse gastric carcinoma?", "Does the image display tumor cells lacking visible cell-cell junctions or desmosomes?", "Can you see cells that appear to have reduced adhesion to the extracellular matrix, possibly indicating invasive or migratory behavior?", "Is there a region where cells seem to traverse anatomical barriers such as the basement membrane or endothelial lining?", "Are there dispersed cells present in organs like the breast, stomach, lymph nodes, or peritoneum?", "Does the image show tumor cells interacting with the tumor stroma, immune cell niches, or extracellular matrix?", "Can you identify areas where fibroblasts, macrophages, lymphocytes, or endothelial cells are found adjacent to dispersed tumor cells?", "Is there a lack of clustering among tumor cells, with most appearing as single, isolated units?", "Do you observe any signs of irregular cytoskeletal structure in cells that are not forming cohesive groups?"], "contexual_behavior": [], "functions": ["Does the image show cells that appear to migrate individually rather than as clusters?", "Can you identify cells that lack visible cell-cell adhesion with their neighbors?", "Is there evidence of cells infiltrating adjacent tissues independently of a primary mass?", "Do you see cells that could be facilitating tissue invasion by detaching from a main tumor?", "Are there cells dispersed in a way that suggests potential for metastatic spread?", "Can you observe any cells that might be entering or interacting with blood vessels, indicating circulatory entry?", "Is there visual evidence of cells degrading or remodeling the surrounding extracellular matrix?", "Do any cells appear to be altering the local tissue microenvironment?", "Are there cells that seem to evade immune detection, such as by lacking typical surface antigens?", "Can you see cells that might be secreting factors to suppress immune responses in their vicinity?", "Do any cells appear to be migrating individually through tissue barriers, possibly exploiting remodeled matrix pathways?", "Is there evidence of cells expressing features consistent with amoeboid or mesenchymal movement?", "Can you identify cells that might be resisting cell death, such as those surviving in detached or stressful environments?", "Are there visually distinct cell populations suggesting phenotypic diversity or genetic variability within the tumor mass?", "Do you see cells that could be influencing angiogenesis, such as by being located near newly formed blood vessels?", "Is there evidence of cells that might be contributing to therapy resistance, for example by surviving in areas exposed to cytotoxic agents?", "Can you observe interactions between tumor cells and stromal cells, possibly through paracrine signaling or exosome release?", "Are there cells that appear to have adapted to hypoxic regions, such as by being located in poorly vascularized areas?"]}, "no_questions": {"contexual_properties": ["Can you identify an object that seems shrunken, possibly due to menopause, atrophy, or surgical removal?", "Does the image show a structure with abnormal color, which might indicate hemorrhage, ischemia, or necrosis?", "Can you see signs of altered hormone activity, which might be associated with endocrine disorders, tumors, or polycystic ovary syndrome?"], "properties": ["Does the image contain an area with a surface area of about 6 to 10 square centimeters?", "Does the image show a structure with a pale whitish or grayish-pink appearance?", "Does the image show a structure with significant connective tissue, such as a tunica albuginea or stroma?"], "relational": ["Is there a structure positioned adjacent to the urinary bladder?", "Can you identify tissue surrounded by peritoneum, connective tissue, or mesovarium?", "Does the image show a structure that is part of the female reproductive system?"], "contexual_behavior": ["Can you see a structure that might increase estrogen synthesis to maintain hormonal balance after the loss of its contralateral counterpart?", "Does the image include a structure that could exhibit impaired oocyte maturation during systemic illness or metabolic stress?", "Can you identify a structure whose reproductive capacity might be reduced due to chemotherapy-induced follicular depletion or stromal damage?"], "functions": ["Does the image show an object interacting with the fallopian tube or ovarian stroma to support reproductive processes?", "Is there a visible feature associated with the release of mature oocytes during ovulation?", "Can you see a structure that coordinates hormone production and gamete release to prepare the reproductive tract?"]}}, "linear cords of cells": {"yes_questions": {"contexual_properties": ["Is there a structure that appears thicker, possibly indicating hyperplasia or reactive tissue proliferation?", "Can you identify any regions where a linear arrangement of cells is fragmented, suggesting necrosis or tissue degeneration?", "Do you observe any linear cellular structures with altered coloration that could be due to ischemia, hemorrhage, or pigment deposition?", "Is there evidence of elongated linear cellular formations, which might suggest tissue growth or regeneration?", "Are there any linear cellular structures that appear shortened, possibly due to atrophy or tissue contraction?", "Do you see areas where the density of cells in a linear pattern is abnormal, which could indicate neoplasia or dysplasia?", "Are there linear cellular structures that appear disrupted, potentially due to trauma, inflammation, or tumor invasion?", "Can you identify regions where linear arrangements of cells show increased cellularity, as seen in neoplasia or reactive hyperplasia?", "Is there a linear cellular structure with irregular borders, possibly reflecting malignancy or invasive disease?", "Do you observe any linear arrangements of cells showing necrosis, which might be due to ischemia, infection, or toxic injury?", "Are there linear cellular structures that appear more prominent, suggesting a fibrotic or reparative tissue response?", "Can you see any linear cell formations that have lost structural integrity, possibly as a result of enzymatic degradation or severe inflammation?", "Is there evidence of compositional change in linear cellular structures, such as might occur during metaplasia or extracellular matrix remodeling?", "Do you observe increased mitotic figures within linear cellular arrangements, which could indicate a high-grade neoplasm or rapid tissue turnover?", "Are there linear cellular structures that appear less distinct, possibly due to edema, inflammation, or tissue dissolution?", "Can you identify infiltration of inflammatory cells within linear arrangements, as might be seen in acute or chronic inflammation?", "Is there a linear cellular structure that appears hyalinized, suggesting chronic injury or sclerosis?", "Do you see evidence of edema within linear cellular formations, potentially due to increased vascular permeability or inflammation?", "Are there any linear cellular structures exhibiting calcification, as seen in dystrophic or metastatic calcification?", "Can you identify linear arrangements of cells with increased extracellular matrix, which could indicate fibrosis or tissue scarring?"], "properties": ["Does the image show elongated, narrow structures that are straight or gently curved?", "Can you identify any features that appear as single-file or parallel arrangements of cells?", "Is there a structure present where the width is approximately one to two cells across, measuring about 10\u201330 micrometers?", "Do you see any formations that are only a single cell layer thick, roughly 5\u201315 micrometers?", "Are there areas where cells are closely packed together with minimal space between them?", "Can you find structures composed of hepatocytes, epithelial cells, or tumor cells arranged in a linear fashion?", "Is there a visible feature with a high length-to-width ratio, possibly exceeding 10:1?", "Do any structures contain nuclei that are aligned along the long axis of the formation?", "Can you observe eosinophilic or pale pink staining patterns with distinct cell borders and nuclei?", "Are there elongated formations with sparse extracellular matrix, mainly composed of basal lamina components like collagen or laminin?", "Do you see structures where the number of cells ranges from a few to several dozen in a linear sequence?", "Is there evidence of cytoplasm rich in organelles such as mitochondria or endoplasmic reticulum within any linear arrangements?", "Are there regions where the mitotic index appears low, or do you notice areas where it is elevated, suggesting a pathological process?"], "relational": ["Does the image show a tissue from the endocrine or digestive system that contains parallel or layered arrangements of cells?", "Can you identify structures in the abdominal cavity, neck, or retroperitoneal space that are composed of elongated groups of cells?", "Is there evidence of hepatic plates or glandular zones formed by rows of cells in the image?", "Does the image display regions where hepatocytes, adrenal cortical cells, or parathyroid chief cells are arranged in a linear fashion?", "Can you see areas where cell cords are surrounded by reticular connective tissue or supported by a stromal matrix?", "Is there a structure in the image where capillaries or sinusoids interact closely with organized rows of cells?", "Does the image contain lobules or parenchymal regions characterized by cords of cells?", "Can you identify an organ, such as the liver, adrenal gland, or parathyroid gland, that displays linear arrangements of its cellular components?", "Is there a visible pattern of radial or parallel organization among cells within a glandular or hepatic tissue?"], "contexual_behavior": ["Does the image show any cellular arrangements that might have reduced regenerative capacity in the context of chronic injury or fibrosis?", "Can you identify structures that could exhibit impaired cellular communication under hypoxic conditions, such as disrupted gap junctions?", "Is there evidence of increased cellular proliferation or activity in response to tissue damage or wound healing?", "Do you observe any misaligned cellular patterns that might suggest disrupted cytoskeletal organization or altered extracellular matrix cues under mechanical stress?", "Are there cellular formations that appear less metabolically active, possibly due to nutrient deprivation or energy conservation?", "Can you see any cell groups that might be responding to inflammatory cytokines, as indicated by changes in behavior or gene expression?", "Is there visual evidence of loss of structural integrity in cellular arrangements, potentially due to chronic inflammation or pathological remodeling?", "Do you observe features suggesting enhanced migration, proliferation, or extracellular matrix production as part of a tissue repair response?", "Are there signs of reduced cell-cell signaling or impaired connectivity that could be associated with degenerative diseases?", "Can you identify cellular patterns that suggest increased migration in response to developmental cues or morphogen gradients?", "Is there evidence of disrupted tissue architecture or loss of polarity that might indicate malignant transformation or cancerous conditions?", "Do you see any changes in cell adhesion, migration, or differentiation that could be linked to altered extracellular matrix composition?", "Are there indications of reduced functional connectivity or increased cellular senescence in aging tissues?", "Can you identify cellular arrangements that appear more resistant to apoptosis, possibly due to upregulated survival pathways under stress?", "Is there evidence of impaired differentiation among cells, potentially due to mutations affecting developmental signaling pathways in genetic disorders?"], "functions": ["Does the image show any structures that provide organization or alignment to cells within a tissue?", "Can you identify features that act as scaffolds guiding the spatial arrangement of cells?", "Is there evidence of pathways that could facilitate direct cell-to-cell contact and communication?", "Do you see any arrangements that might serve as templates for proliferating or migrating cells during tissue repair?", "Are there visible features that could direct the movement of cells within developing or healing tissues?", "Can you find structures that might establish the initial architecture for organ-specific development?", "Is there any indication of guides or precursors for new blood vessel formation in the image?", "Do you observe patterns that could be involved in organizing migrating cells at an injury site?", "Are there features that appear to preserve the alignment and integrity of cellular arrangements?", "Can you see arrangements that might mediate contact-dependent signaling between different cell types?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify any anatomical features such as the cornea, lens, retina, sclera, or iris?", "Does the specimen appear to be contained within the ocular system or nervous system?", "Can you observe cellular components like photoreceptors, retinal ganglion cells, endothelial cells, or fibroblasts?"], "contexual_behavior": ["Is there a structure where enzymatic activity might be better preserved if milder chemicals and shorter processing times were used?", "Is there a region where increased autofluorescence could indicate the use of aldehyde-based chemicals or extended fixation?", "Is there evidence of a structure that would no longer respond to light due to chemical treatment?"], "functions": ["Are there signs of biological processes such as apoptosis, cell proliferation, or tissue remodeling within the ocular tissue?", "Does the image reveal pathological changes or features that could be associated with disease mechanisms in the eye?", "Does the specimen provide visual cues about developmental stages or cellular differentiation within ocular tissues?"]}}}
[ { "answer": "x-ray showing large sella turcica", "extracted_concepts": [ "large sella turcica", "x-ray" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "large sella turcica", "x-ray" ], "question": "does this image show x-ray showing large sella turcica?" }, { "answer": "no", "extracted_concepts": [ "lip remote", "large sella turcica", "x-ray", "squamous cell carcinoma" ], "question": "does squamous cell carcinoma, lip remote, show x-ray showing large sella turcica?" }, { "answer": "bone", "extracted_concepts": [ "bone" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "bone", "calvarium" ], "question": "is bone, calvarium present?" }, { "answer": "no", "extracted_concepts": [ "bone", "skull" ], "question": "is bone, skull present?" }, { "answer": "chromophobe adenoma", "extracted_concepts": [ "chromophobe adenoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "chromophobe adenoma" ], "question": "is chromophobe adenoma present?" }, { "answer": "no", "extracted_concepts": [ "nose", "hemisection of nose" ], "question": "is hemisection of nose present?" }, { "answer": "bone, calvarium", "extracted_concepts": [ "bone", "calvarium" ], "question": "what is present?" }, { "answer": "chromophobe adenoma", "extracted_concepts": [ "chromophobe adenoma" ], "question": "what is present?" } ]	["large sella turcica", "hemisection of nose", "bone", "chromophobe adenoma", "nose", "skull", "squamous cell carcinoma", "lip remote", "calvarium", "x-ray"]	{"large sella turcica": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a bony depression in the sphenoid bone that appears enlarged compared to standard reference values?", "Can you identify a structure whose length exceeds 12 mm or depth is greater than 16 mm?", "Is there an area with a volume above 1000 mm\u00b3 visible in the image?", "Does the image contain a saddle-like or oval-shaped depression within the cranial base?", "Can you see a bony structure with a surface area greater than 150 mm\u00b2?", "Is there a region where the bone thickness measures between 2 and 4 mm despite overall enlargement?", "Does the image show a well-corticated, smooth, and well-defined contour in a bony depression?", "Can you identify a structure whose bone density is similar to adjacent cranial bone, typically between 800 and 1200 HU on CT?", "Is there evidence of asymmetry, deepening, or remodeling of the floor in a prominent cranial depression?", "Does the image display a bony depression with an enlarged height, width, or depth compared to normal reference values?"], "relational": ["Does the image show a bony depression within the middle cranial fossa?", "Can you identify a structure adjacent to both the sphenoid and temporal bones?", "Is there a cavity that houses the pituitary gland and its stalk?", "Does the image reveal an enlarged space that could indicate pituitary gland enlargement or pathology?", "Can you see a region defined anteriorly by the tuberculum sellae and posteriorly by the dorsum sellae?", "Is there a structure bordered laterally by the sphenoid bone?", "Does the image include anatomical features such as the clinoid processes or the sphenoidal sinus?", "Can you identify a dural fold, such as the diaphragma sellae, overlying a bony cavity?", "Is there a depression forming part of the superior surface of the sphenoid bone?", "Are there nearby nerves or vessels, such as the optic chiasm, cavernous sinus, or internal carotid arteries, in proximity to a bony cavity?"], "contexual_behavior": ["Does the image show evidence of a structure that could compress or displace pituitary tissue, as seen in conditions like empty sella syndrome or pituitary tumors?", "Is there a feature present that might lead to altered hormone secretion patterns due to compression or damage of pituitary tissue?", "Can you identify an abnormality that could interfere with the regulation of endocrine functions by affecting hormone synthesis or release?", "Does the image reveal a situation where increased intracranial pressure might decrease the production of pituitary hormones by compressing the gland?", "Is there any indication of anatomical distortion that could impair the pituitary's response to physiological stress?", "Can you see a structural change that might disrupt feedback regulation within the hypothalamic-pituitary axis due to glandular compression?", "Is there a visible lesion or expansion that could cause abnormal pituitary function by compressing or invading the gland?", "Does the image suggest a structural abnormality that could hinder hormonal adaptation during puberty or pregnancy?", "Is there evidence of sella expansion or deformation that might compromise the pituitary's ability to respond to metabolic demands?", "Can you detect features that might exacerbate pituitary dysfunction during traumatic brain injury, such as glandular compression or vascular disruption within an enlarged sella?"], "functions": ["Does the image show evidence of a structure whose enlargement could alter the morphology or function of the pituitary gland?", "Is there a feature present that might indicate compression or displacement of the gland responsible for hormone secretion?", "Can you identify any signs that suggest possible disruption of normal hormone regulation due to changes in a bony cranial structure?", "Does the image reveal any abnormality that could lead to endocrine system imbalance or altered hormonal output?", "Is there visual evidence of a cranial alteration that might be associated with neurological symptoms such as headaches or visual disturbances?", "Can you see any indication that the structural support or protection for the pituitary gland is reduced, potentially increasing its vulnerability?", "Does the image display changes in cranial anatomy that could affect intracranial pressure or suggest local bone remodeling?", "Is there a feature that might influence cerebrospinal fluid dynamics, possibly leading to conditions like empty sella syndrome?", "Can you observe any abnormality that could impact the visual pathway, such as exerting pressure on the optic chiasm or adjacent visual structures?"]}, "no_questions": {"contexual_properties": ["Are there any regions with central cavitation, which might result from tissue breakdown due to necrosis?", "Does the image show any areas that have increased in size, suggesting tumor growth or disease progression?", "Is there evidence of changes in lesion composition, such as necrosis, fibrosis, calcification, or cystic transformation?"], "properties": ["Are there cells with an increased nuclear-to-cytoplasmic ratio visible within any of the lesions?", "On MRI images, do any lesions show heterogeneous signal intensity, being hypointense on T1 and hyperintense on T2 sequences?", "Is there evidence of rapid cell proliferation, such as a high mitotic index, in any of the visible structures?"], "relational": ["Are there abnormal findings in organs like the liver, lungs, brain, bones, or lymph nodes that could indicate secondary tumor involvement?", "Are there signs of abnormal tissue that could be explained by lymphatic spread, lymph node infiltration, or lymphovascular invasion?", "Does the image display any structures adjacent to abnormal masses, such as blood vessels, nerves, or surrounding parenchyma?"], "contexual_behavior": ["Is there a decrease in vascular permeability or stabilization of blood vessels in areas that might have received anti-angiogenic treatment?", "Can you identify regions that seem less affected by immune cells, indicating possible resistance to immune surveillance?", "Is there an area where normal organ function appears compromised due to the size or invasive nature of a lesion?"], "functions": ["Does the image show abnormal growth patterns that could indicate immune evasion by a lesion?", "Does the image show secondary tumor sites in distant organs, indicating the spread of cancer?", "Are there signs of increased metabolic demand, such as regions with dense cellularity or altered tissue appearance?"]}}, "hemisection of nose": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a sagittal section with a curved, triangular profile measuring approximately 2\u20133 cm in width and 3\u20134 cm in height?", "Can you identify a structure that appears to be about half the size of a typical nose?", "Is there an object present that could weigh between 10 and 20 grams based on its size and tissue composition?", "Does the image contain a section displaying pink to reddish coloration due to high vascularization?", "Can you see tissues such as cartilage, bone, mucosa, skin, or connective tissue within a single section?", "Is there evidence of cell types like epithelial cells, chondrocytes, osteocytes, fibroblasts, or endothelial cells in the depicted structure?", "Does the mucosal lining of the section appear to be between 1 and 4 mm thick?", "Can you identify cartilage structures such as septal cartilage, lateral nasal cartilage, or alar cartilage within the section?", "Is there bone present that could correspond to the nasal bone, maxilla, ethmoid bone, or vomer?", "Does the structure exhibit high vascular density, with numerous capillaries or venous plexuses visible?", "Is there an area lined by pseudostratified ciliated columnar epithelium or squamous epithelium?", "Can you infer that the water content of the tissue is approximately 60\u201370% by weight?", "Does the surface area of the section appear to be within the range of 10\u201315 cm\u00b2?", "Is the density of the tissue similar to that of soft tissue, around 1.05\u20131.10 g/cm\u00b3?", "Can you identify a mucosal region that would likely have a slightly acidic pH, around 5.5\u20136.5?"], "relational": ["Does the image show a structure where the nasal septum is visibly divided along the midline?", "Can you identify an anatomical view that separates the left and right halves of both the external and internal nose?", "Is there a region in the image where the nasal cavity and lateral nasal wall are exposed?", "Does the image display tissues such as mucosa, cartilage, bone, and skin within the same section?", "Are bones like the nasal bone, maxilla, or ethmoid bone visible in the exposed area?", "Can you see structures such as the nasal conchae or meatuses within a single nasal cavity?", "Is there evidence of cartilaginous elements such as septal cartilage, lateral nasal cartilage, or alar cartilage being sectioned?", "Does the image reveal the nasal septum in a way that suggests a midline division?", "Are adjacent facial structures like the upper lip, maxillary sinus, or orbit visible in continuity with the exposed nasal area?", "Can you identify a connection between the exposed nasal region and the upper respiratory tract, specifically the nasopharynx?", "Are vascular structures such as branches of the sphenopalatine artery, facial artery, or anterior ethmoidal artery visible in the sectioned area?"], "contexual_behavior": [], "functions": ["Does the image show a surgical alteration that provides access to internal nasal or paranasal structures?", "Is there evidence of a procedure that could disrupt the continuity of the nasal passages, potentially causing airflow obstruction or turbulence?", "Can you identify a modification that would allow for enhanced visualization or instrumentation of deep nasal regions?", "Does the image suggest a change that might impair the sense of smell by affecting the olfactory region or its airflow?", "Is there visible disruption of the mucosal lining that could compromise mucociliary clearance or increase infection risk?", "Can you see anatomical changes that might make nasal breathing less efficient due to increased airway resistance?", "Is there an alteration that could affect normal sinus drainage pathways, possibly increasing the risk of sinusitis?", "Does the image show a loss of mucosal surface or barriers that would reduce the nasal cavity's filtration and humidification functions?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a region where the normal layering of cells is disrupted and tissue organization is lost?", "Does the image show an area with more than two layers of cells, exceeding the normal single or double layer?", "Does the image show a region with cells that have enlarged, darkly staining nuclei and loss of their usual orientation?"], "relational": ["Is there a structure that could potentially progress to carcinoma or adenocarcinoma?", "Can you identify a region that is juxtaposed to, or appears to transition from, adjacent normal tissue?", "Does the image reveal cells with features of dysplasia, such as abnormal epithelial, basal, or glandular cells?"], "contexual_behavior": ["Does the image reveal a lesion with accelerated growth, potentially linked to exposure to carcinogens and acquisition of additional mutations?", "Does the image show a region where contact inhibition is lost, possibly under mechanical stress or due to disrupted cell-cell signaling?", "Is there a region where normal tissue architecture is disrupted, potentially due to loss of cell polarity or adhesion molecules?"], "functions": ["Does the image reveal disorganization of cellular layers or loss of polarity within the tissue?", "Can you see a structure that could represent the initial step in the multistep process of cancer development?", "Can you identify a region that might serve as an early indicator for disease progression toward invasive cancer?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": ["Is there any ulceration present that could result from a malignant tumor invading the skin or a severe infection?", "Is there any sign of tissue necrosis that could be caused by severe infection, abscess, or advanced malignancy?", "Is there evidence of volume loss that might follow atrophy, surgery, or radiation therapy?"], "properties": ["Is the density of the affected tissue higher than what would be expected in normal breast tissue?", "Does the image suggest a molecular subtype such as luminal A, luminal B, HER2-enriched, or triple negative?", "Is there evidence of inflammatory infiltrates or cellular atypia within the tissue?"], "relational": ["Is there evidence of changes involving the mammary glands, ducts, lobules, or nipple?", "Is there evidence of abnormality in cell types such as epithelial cells, myoepithelial cells, adipocytes, or immune cells?", "Does the image reveal any changes in the lactiferous ducts, terminal duct lobular units, or major lobules?"], "contexual_behavior": ["Does the image show changes in metabolic activity of breast cells, such as areas of altered density that might indicate neoplastic transformation or inflammation?", "Can you identify alterations in the vascular supply to breast tissue, such as compressed or invaded blood vessels?", "Does the image suggest a decreased response to hormonal changes during the menstrual cycle, possibly due to altered hormone receptor function?"], "functions": ["Can you observe any disruptions in normal tissue remodeling, such as an imbalance between cell proliferation and apoptosis?", "Can you identify any signs of decreased milk production or obstruction of glandular ducts in the relevant area?", "Is there evidence of abnormal cell growth, impaired apoptosis, or possible tumor formation in the tissue?"]}}, "chromophobe adenoma": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a lesion measuring between 1 and 3 centimeters in diameter visible in the image?", "Can you identify a mass that appears to weigh less than 10 grams based on its size and context?", "Does the image show a round or oval structure?", "Is there a mass with a pale tan or grayish-white coloration?", "Can you see a tumor composed predominantly of cells with abundant pale cytoplasm and sparse supporting stroma?", "Does the lesion exhibit a low mitotic index, with rare mitotic figures present?", "Is there evidence of cells with a low to moderate nuclear-cytoplasmic ratio within the mass?", "Can you observe cells with abundant, pale, and finely granular cytoplasm in the structure?", "Does the image show cells with a fine and evenly distributed chromatin pattern?", "Is there a mass that appears to have high water content, as suggested by the cytoplasmic features?", "Can you identify a tumor with low lipid content based on its histological appearance?", "Does the structure display low hormone expression and positive staining for cytokeratins?", "Is there a tumor with moderate cell density compared to other pituitary neoplasms?", "Does the lesion appear to have a slow growth rate based on its characteristics?", "Can you see evidence of low or absent hormone content, indicating a non-functioning tumor?", "Is there a mass with low to moderate vascularity visible in the image?", "Does the structure show rare or infrequent calcification?", "Can you identify a lesion with a soft and rubbery texture?", "Is there minimal to mild fibrosis present in the tumor?", "Does the mass exhibit a very low rate of necrosis?"], "relational": ["Does the image show a lesion affecting the endocrine system?", "Is there an abnormality associated with the pituitary gland?", "Can you identify a mass located in the sellar region of the brain?", "Is there evidence of a structure adjacent to the optic chiasm or cavernous sinus?", "Does the image reveal a lesion near the sphenoid sinus?", "Is there a mass surrounded by dura mater or the pituitary capsule?", "Can you see an abnormality involving the anterior lobe (pars distalis) of the pituitary gland?", "Is there a lesion supplied by the superior or inferior hypophyseal arteries?", "Does the image show a mass in proximity to the optic nerve, oculomotor nerve, or abducens nerve?", "Is there evidence of expansion or involvement of the sella turcica?", "Can you identify a structure that appears to compress the optic chiasm or cavernous sinus?", "Does the image show a lesion adjacent to brain parenchyma?"], "contexual_behavior": ["Is there evidence of a mass within the sella turcica that could be compressing or destroying healthy pituitary tissue?", "Does the image show a lesion that might be associated with reduced secretion of pituitary hormones?", "Can you identify a structure that could cause pituitary dysfunction by exerting pressure on surrounding tissue?", "Is there a mass that appears non-secretory, even under stress conditions?", "Does the image suggest the presence of a tumor that might show reduced metabolic activity in a hypoxic environment?", "Can you see a lesion whose hormone secretion patterns could be altered by medications affecting pituitary or hypothalamic signaling?", "Is there a structure that could disrupt endocrine feedback loops by failing to respond to regulatory hormones?", "Does the image show a mass that might decrease in size or growth rate following radiotherapy?", "Is there evidence of a lesion that could interfere with normal hormonal rhythms, especially during sleep deprivation?", "Can you identify a mass that increases pressure on adjacent pituitary tissue as it enlarges?", "Is there a structure that might show reduced responsiveness to hypothalamic signals due to receptor deficiency?", "Does the image suggest a lesion whose secretory behavior could change during pregnancy?", "Can you see a mass that might fail to suppress hormone secretion in response to negative feedback mechanisms?", "Is there evidence of increased proliferative activity in response to growth factors within a pituitary mass?", "Does the image show a lesion that could lead to decreased hormone output after surgical removal or damage to hormone-producing tissue?", "Can you identify a structure that might impair water balance regulation, particularly if antidiuretic hormone production is affected?"], "functions": ["Does the image show a pituitary tumor composed of cells that do not appear to be actively secreting hormones?", "Is there evidence of a mass that could cause reduced or absent secretion of pituitary hormones, potentially leading to endocrine dysfunction?", "Can you identify a lesion that might compress normal pituitary tissue and impair hormone production?", "Does the image contain a structure that could disrupt the regulation of peripheral endocrine glands by decreasing trophic hormone output?", "Is there a mass that could be responsible for metabolic dysregulation due to decreased levels of hormones such as ACTH, TSH, or GH?", "Can you see a lesion that might interfere with the normal feedback mechanisms between the hypothalamus, pituitary, and target glands?", "Is there a structure that could explain growth impairment or developmental delay due to reduced growth hormone secretion?", "Does the image show a mass that could be responsible for hormonal imbalances or deficiencies in one or more pituitary hormones?", "Can you identify a lesion that might impair the body's stress response by reducing ACTH and consequently cortisol levels?", "Is there evidence of a mass that could interfere with reproductive hormone regulation by lowering LH and FSH secretion, potentially resulting in hypogonadism?"]}, "no_questions": {"contexual_properties": ["Is there evidence of bony overgrowth or osteophyte formation at the foramen magnum possibly related to instability of the atlas vertebra?", "Is there evidence of narrowing at the craniovertebral junction due to displacement of the first cervical vertebra?", "Can you see any obstruction or reduction in the patency of the foramen magnum opening that may be caused by severe displacement of the atlas?"], "properties": ["Does the volume of the opening at the base of the skull appear to be reduced to around 3.5 cubic centimeters?", "Does the image reveal an opening with an irregular and constricted shape due to encroaching bone?", "Can you identify an opening whose diameter measures approximately 18 millimeters, which is below the normal reference range?"], "relational": ["Can you identify the relationship between the first cervical vertebra and the axis vertebra in the image?", "Does the image show any abnormality in the region where the medulla oblongata transitions into the spinal canal?", "Is there evidence of abnormal positioning at the atlanto-occipital joint?"], "contexual_behavior": ["Does the image reveal any abnormal positioning of the atlas vertebra that could compromise the opening at the skull base?", "Can you identify a misalignment of the first cervical vertebra that might affect the passageway for the spinal cord?", "Is there evidence of reduced space where the brainstem transitions into the spinal cord?"], "functions": ["Are there signs of structural changes that could lead to neurological deficits such as motor weakness or sensory loss?", "Does the image suggest increased intracranial pressure or collateral venous drainage as compensatory mechanisms?", "Are there indications of compromised autonomic nervous system control due to compression of descending fibers in the brainstem?"]}}, "skull": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure with an oval or rounded shape and a slightly elongated anteroposterior axis?", "Can you identify an object that appears off-white or pale ivory due to mineralized bone tissue?", "Is there a structure present that could measure approximately 22 cm in length, 17 cm in width, and 14 cm in height?", "Does the image contain an object whose thickness varies between 4 and 8 millimeters depending on the region?", "Can you see a structure that might weigh between 1.3 and 1.5 kilograms in adults?", "Is there an object composed primarily of compact and spongy bone, collagen fibers, hydroxyapatite, and water?", "Does the image include a structure made up of 22 bones, with both cranial and facial components?", "Can you identify an object with a moderate porosity, especially in regions containing spongy bone?", "Is there a structure whose surface appears mostly smooth but with some roughened areas for muscle attachment?", "Does the image show an object with a circumference of about 55 to 58 centimeters?", "Can you see a structure that might have a bone density ranging from 1.5 to 2.0 g/cm\u00b3?", "Is there an object whose water content is approximately 10% by weight?", "Does the image contain a structure with a mineral content mainly consisting of hydroxyapatite, accounting for about 65% of its dry weight?", "Can you identify an object with a calcium concentration of about 20\u201325% and a phosphorus concentration of roughly 10\u201312% of its total weight?", "Is there a structure with a collagen content of about 20\u201325% of its organic matrix?", "Does the image show an object with a typical hardness of around 5 on the Mohs scale?", "Can you see a structure whose cranial cavity volume could be approximately 1350 to 1500 milliliters?"], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify any bones such as the frontal, parietal, or temporal bones?", "Is there a region visible that could correspond to the cranium or facial skeleton?", "Does the image display features like the calvaria or cranial base?", "Can you see any joints such as cranial sutures or the temporomandibular joint?", "Is there evidence of cavities like the cranial, nasal, or orbital cavities?", "Does the image include a structure that protects the brain or eyes?", "Can you identify an articulation point with the vertebral column, such as the foramen magnum?", "Is there a visible area where muscles like the temporalis or masseter might attach?", "Can you see any foramina, such as the optic canal or jugular foramen?", "Are there distinguishing features such as multiple cavities or complex articulations present?", "Does the image show a structure involved in protecting the inner ear or nasal passages?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides protection for the brain?", "Can you identify a rigid bony cavity that encapsulates neural tissue?", "Does the image show a framework that supports sensory organs such as the eyes or ears?", "Is there a visible structure forming orbital or nasal cavities?", "Can you see attachment points for muscles involved in chewing?", "Does the image include features like the mandible or maxilla that enable mastication?", "Is there a bony framework shaping the forehead, cheeks, or jaw?", "Can you identify surfaces or ridges for the attachment of facial muscles responsible for expression?", "Does the image show structures forming the oral or nasal cavities, which facilitate speech resonance?", "Is there evidence of air-filled cavities that could contribute to sound resonance?", "Can you see anatomical features that protect the entrances to the respiratory or digestive tracts?", "Is there a structure maintaining a closed cavity that could help regulate intracranial pressure?"]}, "no_questions": {"contexual_properties": ["Are there regions with denser bright spots that could be related to metabolic disorders or chronic inflammation?", "Does the image reveal irregularly shaped bright areas that might be seen in malignancy or atypical ductal hyperplasia?", "Can you observe bright spots with suspicious shapes or morphologies that could be seen in high-risk lesions or early-stage breast cancer?"], "properties": ["Is there evidence of clustered, linear, or segmental arrangements of small, dense spots?", "Are there high-density, radiopaque features with sizes ranging from 0.1 to 2 millimeters present in the image?", "Is the average diameter of the individual radiopaque foci around 0.5 millimeters?"], "relational": ["Does the image appear to be acquired using digital mammography or tomosynthesis, as opposed to ultrasound or MRI?", "Are there dense regions that appear to be connected to ductal walls, the stromal matrix, or adjacent lobules within the breast tissue?", "Does the image show small, dense areas within the breast parenchyma or ducts that could indicate mineral deposits?"], "contexual_behavior": ["Is there evidence of digital image enhancement that might increase the contrast of tiny bright specks?", "Is there visual evidence of prior surgical intervention, such as scar tissue or altered anatomy, that could affect the detection of small bright deposits?", "Can you observe tissue changes or fibrosis that might be consistent with prior radiation therapy and could obscure small bright deposits?"], "functions": ["Does the image reveal any features that could be critical for early detection during breast cancer screening?", "Does the image show changes that might be used to evaluate response to therapy or treatment?", "Is there evidence of patterns or distributions that could help in recognizing malignant lesions?"]}}, "squamous cell carcinoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show an abnormality in tissues lined by squamous epithelium, such as the skin or mucous membranes?", "Can you identify a lesion affecting regions like the head and neck, cervix, lungs, esophagus, or skin?", "Is there evidence of a process involving squamous epithelial cells?", "Does the image display changes originating from the epithelial layer of any tissue?", "Can you see a mass or lesion that appears to invade deeper structures such as the dermis, submucosa, muscle, or blood vessels?", "Is there involvement of regional lymph nodes or lymphatic vessels adjacent to an abnormal area?", "Does the abnormality appear to impact systems like the integumentary, respiratory, digestive, or reproductive system?", "Can you identify precursor changes such as actinic keratosis, squamous dysplasia, or carcinoma in situ near the affected area?", "Is there visual evidence of neighboring tissues like connective tissue, muscle, nerves, or blood vessels being involved by a lesion?"], "contexual_behavior": [], "functions": ["Does the image show a region where normal epithelial cells appear to be replaced, potentially compromising barrier integrity?", "Is there evidence of uncontrolled cellular growth or abnormal tissue expansion in the image?", "Can you identify areas where tissue architecture is disrupted, suggesting invasion into surrounding structures?", "Does the image reveal signs of extracellular matrix degradation or breach of the basement membrane?", "Is there visual evidence of new blood vessel formation, possibly indicating neovascularization?", "Can you see regions that might be associated with increased inflammation or immune cell infiltration?", "Does the image suggest the presence of activated fibroblasts or changes in the extracellular matrix composition?", "Are there features that could indicate the presence of secondary tumor sites, such as spread through lymphatic or blood vessels?", "Is there a region where normal tissue regeneration appears impaired or where differentiation of progenitor cells seems inhibited?", "Can you identify areas that might be undergoing chronic inflammation, as indicated by persistent immune cell presence or tissue changes?", "Does the image show architectural changes consistent with matrix metalloproteinase activity or tissue remodeling?", "Is there visual evidence of stromal cell recruitment or modification of the local tissue microenvironment?", "Can you detect features that might reflect resistance to programmed cell death, such as dense clusters of atypical cells?", "Are there any regions that could suggest deregulated cell proliferation, such as loss of normal cell cycle control?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure located in the subcutaneous layer, parenchymal region, or on the surface of an organ?", "Does the image reveal a structure that could impact the endocrine, respiratory, or integumentary system?", "Can you identify a lesion affecting organs such as the liver, thyroid, lung, breast, or skin?"], "contexual_behavior": [], "functions": ["Is there evidence of uncontrolled cell division or resistance to growth-inhibitory signals in any visible mass?", "Can you see a structure that may be interfering with the normal function of an organ?", "Does the image include a structure that might be activating oncogenic signaling or inhibiting tumor suppressor pathways?"]}}, "calvarium": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the axial skeleton?", "Can you identify regions formed by the frontal, parietal, or occipital bones?", "Is there a bony area adjacent to the cranial base or covered by the scalp?", "Are there visible joints resembling the coronal, sagittal, or lambdoid sutures?", "Does the image include the superior or lateral portions of the skull?", "Can you see an inner surface lined by membranes such as the dura mater?", "Is there a structure enclosing the cranial cavity or epidural space?", "Does the image show the bony roof of the intracranial space?", "Are there features that, together with the meninges or scalp, could protect the brain?", "Can you identify bones that articulate with the cranial vault, such as the temporal, sphenoid, or ethmoid bones?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Does the image show a region that serves as an attachment site for the meninges or dura mater?", "Is there a visible surface that could support the scalp or provide attachment for facial muscles?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?", "Is there evidence of a closed, non-compressible compartment that helps maintain intracranial pressure?", "Does the image reveal foramina or grooves that might accommodate and protect blood vessels supplying cranial tissues?", "Can you identify a fixed, rigid boundary that regulates the volume of the cranial cavity?", "Is there a bony structure forming part of the orbit or cranial base that helps protect sensory organs such as the eyes or olfactory bulbs?"]}, "no_questions": {"contexual_properties": ["Does the left nasal region appear atrophic or thinned, possibly due to chronic scarring or ischemia?", "Is there an area on the left nasal region that appears unusually pale, suggesting reduced blood flow or vasoconstriction?", "Is there evidence of tissue regeneration or new epithelial growth on the left side of the nose, indicating healing?"], "properties": ["Is there a structure in the image that measures approximately half the total nasal length and width, with dimensions around 2\u20133 cm in width and 4\u20135 cm in length?", "Does the image show a structure with a density close to that of soft tissue, approximately 1.05 g/cm\u00b3?", "Is there a region where cartilage makes up a significant portion, especially in the anterior part, comprising up to 40\u201350% of the structure?"], "relational": ["Are there cartilaginous structures present, such as the left lateral nasal cartilage, left alar cartilage, or septal cartilage?", "Can you see bones like the left nasal bone, left maxilla, left ethmoid bone, or the left inferior nasal concha?", "Can you identify a region that contains both the nasal septum and the lateral nasal wall?"], "contexual_behavior": ["Does the image suggest a decrease in the ability to humidify inspired air due to reduced mucosal lining or altered airflow on one side?", "Is there evidence of impaired warming of inhaled air, possibly due to partial removal of vascularized mucosa or bypassed airflow pathways?", "Can you identify signs of reduced olfactory function on the left side, such as disruption of the olfactory epithelium or altered airflow to the olfactory region?"], "functions": ["Can you observe any abnormality that could interfere with the drainage of nasal secretions on the left, increasing the risk of sinus blockage?", "Is there an asymmetry in the nasal region that could result in reduced airflow on the left and possible compensatory breathing on the right?", "Does the image suggest a condition that might indirectly diminish the sense of taste by reducing olfactory input?"]}}, "x-ray": {"yes_questions": {"contexual_properties": ["Does the image display increased opacity that could indicate accumulation of fluid, infection, or a mass in a particular area?", "Is there evidence of decreased density that might suggest loss of normal tissue mass, as seen in conditions like emphysema or osteoporosis?", "Can you identify abnormal shadows that could be due to tumors, infiltrates, or the presence of a foreign body?", "Does the image reveal any enlarged organs, such as an increased heart or liver size, which might indicate organomegaly?", "Is there visible thinning of bone structures that could be consistent with decreased bone mineral content?", "Can you see signs of fluid accumulation in spaces like the pleura or abdomen?", "Does the image show any areas of calcification that might result from chronic inflammation or metabolic disorders?", "Is there evidence of tissue swelling, such as increased soft tissue volume from inflammation, trauma, or infection?", "Can you detect loss of normal anatomical structure that could be due to destruction or distortion from trauma, infection, or malignancy?", "Does the image reveal any disruptions in bone continuity that might indicate a fracture?", "Are there abnormal air patterns present, such as air outside normal anatomical locations?", "Can you observe changes in lung volume, such as hyperinflation or collapse, that might be related to diseases like COPD or atelectasis?", "Is there narrowing of joint spaces that could suggest degenerative or inflammatory joint disease?", "Does the image show any abnormal soft tissue or bone growths that might represent a mass or tumor?", "Can you identify areas of bone overgrowth, such as excessive bone formation or osteophytes?", "Is there abnormal alignment of bones or joints, such as displacement or angulation, visible in the image?", "Does the image display changes in bone density that could be associated with metabolic or neoplastic bone diseases?", "Is there evidence of soft tissue thickening that might result from inflammation, infection, or neoplastic infiltration?", "Can you see an abnormal heart size that could indicate cardiac enlargement?", "Does the image reveal loss of bone structure that could be due to infection, malignancy, or severe trauma?"], "properties": ["Does the image display features that could be produced by electromagnetic radiation with a wavelength between 0.01 and 10 nanometers?", "Is there evidence of imaging that relies on photon energies in the range of 1 to 150 kiloelectronvolts?", "Can you identify visual characteristics that suggest the use of electromagnetic waves with frequencies between 3 \u00d7 10^16 and 3 \u00d7 10^19 hertz?", "Does the image show structures that would require penetration depths of 1 to 10 centimeters in soft tissue?", "Are there visual differences that could be explained by an attenuation coefficient of 0.2 to 0.5 per centimeter in bone?", "Is the image quality consistent with an intensity of 10^4 to 10^6 photons per square millimeter per second?", "Does the visual appearance suggest a radiation dose in the range of 0.01 to 0.1 millisieverts?", "Can you infer that the exposure duration for this image was between 1 and 500 milliseconds?", "Is the spatial resolution of the image within the range of 0.1 to 0.5 millimeters?", "Does the image exhibit contrast levels that could result from a 1% to 5% difference in tissue density?", "Is the grayscale range of the image consistent with 8 to 16 bits per pixel?", "Can you deduce that the photon flux used to create this image was between 10^12 and 10^15 photons per second?", "Does the image field appear to have a width between 0.5 and 2 millimeters for the beam used?", "Is the field size of the image within the range of 18 \u00d7 24 centimeters to 35 \u00d7 43 centimeters?", "Does the image suggest that the energy spectrum of the beam was continuous from 20 to 150 kiloelectronvolts?", "Can you infer that the voltage used to generate the image was between 40 and 150 kilovolts peak?", "Is there evidence that the current used in the imaging process was between 1 and 500 milliamperes?", "Does the image display a noise level that could be between 1% and 10% of the signal?", "Is the film sensitivity implied by the image quality within the 100 to 400 speed index range?"], "relational": ["Does the image allow visualization of structures such as bones or joints?", "Can you identify regions like the chest, abdomen, or limbs being examined?", "Is there evidence of tissues with varying densities, such as bone, air-filled spaces, or soft tissue?", "Does the image provide information about the skeletal, respiratory, or cardiovascular systems?", "Can you assess bone alignment or joint spaces in the image?", "Is there a visible structure that could be the femur, tibia, or spine?", "Can you see organs such as the lungs or heart in the image?", "Is the position of the trachea or diaphragm discernible?", "Does the image reveal any signs of fractures, dislocations, or calcifications?", "Can you identify anatomical planes such as lateral or anteroposterior views?", "Is there a body part, such as the hand, foot, or pelvis, positioned specifically for examination?", "Can you detect any abnormalities like tumors or infections in the visible structures?", "Does the image show the relationship between bones and surrounding soft tissues?", "Is it possible to evaluate organ position within the thoracic or abdominal cavity?", "Can you distinguish fat from other soft tissues in the image?"], "contexual_behavior": ["Does the image suggest reduced diagnostic effectiveness in the presence of increased tissue thickness, such as in obese individuals?", "Can you determine if the image provides primarily structural rather than functional information, especially in the context of acute inflammation?", "Is there evidence that the detection of bone fractures in the image would not be improved by the use of a contrast agent?", "Does the image appear to have difficulty revealing soft tissue abnormalities that might be present in early stages of disease?", "Can you identify pulmonary changes, such as consolidation or infiltrates, that would become more apparent in the setting of pneumonia?", "Is there a reduction in the ability to detect tumors when dense tissue or overlapping structures are present in the image?", "Does the image suggest potential impairment of cellular function in radiosensitive tissues if the radiation dose is high?", "Can you observe any artifacts or obscured anatomical details that might be caused by the presence of metallic implants?", "Is there altered visualization of organs that could be related to physiological changes during pregnancy or efforts to minimize fetal radiation exposure?", "Does the image show signs that could result from repeated exposure, such as increased DNA damage or impaired DNA repair mechanisms?", "Is there enhanced detection of radiopaque calcifications that might be associated with chronic kidney disease?", "Does the image make it difficult to distinguish between acute and chronic bone infections due to similar radiographic features?", "Is the reliability of the image reduced by increased soft tissue density, as might occur in severe edema?", "Can you see improved visualization of lung fields that could result from deep inspiration and increased air volume?", "Does the image have limited diagnostic value for detecting early-stage osteoarthritis due to the invisibility of initial cartilage loss?"], "functions": ["Does the image provide visual information that could assist in diagnosing internal body structures?", "Can you identify any discontinuities or abnormal alignments in bones that might indicate a fracture?", "Is there evidence of abnormalities in the lungs, such as infiltrates, masses, or fluid accumulation?", "Does the image allow for comparison with previous images to monitor changes in anatomical structures over time?", "Can you see features that would help guide a medical procedure, such as the placement of a catheter or orthopedic hardware?", "Are there visible signs of dental issues, such as cavities, tooth decay, or bone loss in the jaw or teeth?", "Is there an abnormal mass, lesion, or calcification present that could suggest malignancy?", "Can you assess the alignment of bones, joint spaces, or signs of degeneration in joints or the spine?", "Are there any indications of chest abnormalities, such as pneumonia, pleural effusion, or enlargement of the heart?", "Is there a radiopaque object visible that could represent a foreign body within tissues or organs?"]}, "no_questions": {"contexual_properties": ["Can you observe any abnormal accumulation of fluid within the abdominal cavity?", "Is there any indication of fibrous tissue formation or areas of fibrosis within the peritoneal surfaces?", "Does the peritoneal lining appear more opaque or thickened than usual, obscuring its normal translucency?"], "properties": ["Are there areas that could indicate elevated mucin content, especially in the context of mucinous tumors?", "Do you observe nodules that appear white, gray, or tan in color?", "Is there evidence of tumor deposits with an average thickness between 1 and 10 millimeters?"], "relational": ["Can you identify any involvement of the omentum or omental fat?", "Does the image reveal changes associated with the parietal or visceral peritoneum?", "Can you observe features that might indicate dissemination via peritoneal fluid, the omentum, or the mesentery?"], "contexual_behavior": ["Does the image show features consistent with mechanical obstruction or compression of the bowel or mesentery that could disrupt intestinal motility?", "Can you observe any signs of ascites formation, such as free fluid in the abdomen, that could result from increased vascular permeability or impaired lymphatic drainage?", "Does the image reveal disruption of the mesothelial layer or increased permeability in the peritoneum, suggesting barrier breakdown due to malignant infiltration?"], "functions": ["Does the image show features like bowel wall infiltration, adhesions, or mechanical obstruction that could interfere with gastrointestinal motility?", "Can you see features consistent with exfoliation and implantation of malignant cells within the abdomen?", "Does the image reveal signs of chronic inflammation or immune cell recruitment in the peritoneal cavity?"]}}}
[ { "answer": "the late-phase reaction", "extracted_concepts": [ "t cells", "eosinophils", "inflammatory infiltrate", "late-phase reaction", "neutrophils" ], "question": "what is characterized by an inflammatory infiltrate rich in eosinophils, neutrophils, and t cells?" }, { "answer": "an inflammatory infiltrate rich in eosinophils", "extracted_concepts": [ "eosinophils", "inflammatory infiltrate", "late-phase reaction" ], "question": "what is the late-phase reaction characterized by?" }, { "answer": "no", "extracted_concepts": [ "t cells", "eosinophils", "inflammatory infiltrate", "immediate reaction", "neutrophils" ], "question": "is the immediate reaction characterized by an inflammatory infiltrate rich in eosinophils, neutrophils, and t cells?" }, { "answer": "no", "extracted_concepts": [ "area of central necrosis", "t cells", "eosinophils", "inflammatory infiltrate", "typical tuberculous granuloma", "neutrophils" ], "question": "is typical tuberculous granuloma showing an area of central necrosis characterized by an inflammatory infiltrate rich in eosinophils, neutrophils, and t cells?" } ]	["area of central necrosis", "t cells", "eosinophils", "inflammatory infiltrate", "typical tuberculous granuloma", "immediate reaction", "neutrophils", "late-phase reaction"]	{"immediate reaction": {"yes_questions": {"contexual_properties": ["Does the image show evidence of swelling that could have developed within minutes of exposure to an allergen?", "Can you identify an area of redness that may have appeared shortly after contact with a triggering substance?", "Is there a region with increased temperature that might indicate enhanced blood flow due to an acute inflammatory response?", "Does the image display signs consistent with rapid mediator release, such as mast cell activation?", "Can you see visible hives or urticaria that could have formed within minutes following exposure to an allergen?", "Is there evidence of tissue edema that may have developed rapidly after exposure, possibly due to increased vascular permeability?", "Does the image suggest an increased presence of white blood cells as part of an acute inflammatory process?", "Can you observe any features that might indicate a sudden drop in blood pressure, such as signs of anaphylaxis?", "Is there any indication of airway narrowing or constriction that could have occurred rapidly after allergen exposure?", "Does the image show skin pallor that might result from systemic vasoconstriction or shock?", "Can you identify increased mucus production that may have occurred soon after allergen exposure?", "Is there visual evidence of a change in heart rate, such as tachycardia, that could be a response to hypotension?", "Does the image reveal signs of increased vascular permeability, such as localized fluid accumulation?", "Can you detect features that might be associated with a rise in serum tryptase levels following mast cell activation?", "Is there visible wheal formation that could have developed within minutes due to localized edema and vasodilation?"], "properties": ["Does the image show any physical signs such as red, raised, itchy welts or swelling?", "Is there evidence of swelling or welts measuring between 1 and 10 centimeters in diameter?", "Can you identify features consistent with urticaria, erythema, or angioedema?", "Does the image suggest a rapid onset of symptoms occurring within 30 minutes of exposure?", "Are there visual cues indicating symptoms that last less than 24 hours?", "Is there any indication of moderate to severe symptom intensity?", "Can you observe signs that might be associated with a life-threatening allergic response?", "Does the image suggest an elevated heart rate, such as visible tachycardia?", "Are there signs of decreased blood pressure or hypotension present?", "Is there any evidence of increased respiratory rate, such as rapid breathing?", "Can you see indications of decreased blood oxygen saturation, such as cyanosis?", "Is there any visual sign that could suggest a mild increase in body temperature?", "Does the image provide clues to elevated histamine or tryptase levels, such as pronounced skin or airway changes?", "Are there features that might indicate the development of mild acidosis, such as altered breathing patterns?"], "relational": ["Does the image show evidence of a process involving the immune, integumentary, or respiratory systems?", "Can you identify cells such as mast cells, basophils, or eosinophils participating in a visible reaction?", "Is there a visible interaction between connective tissue, mucosal tissue, or vascular endothelium?", "Does the image display changes in the skin, airways, or blood vessels that could indicate a rapid response?", "Can you see features consistent with a type I hypersensitivity or an IgE-mediated response?", "Is there evidence of a reaction occurring in the skin, nasal mucosa, bronchi, or gastrointestinal tract?", "Does the image suggest the release of molecules like histamine, leukotrienes, or prostaglandins?", "Can you identify structures such as nerve endings, blood vessels, or lymphatic vessels involved in a rapid communication process?", "Are immune cells like mast cells, basophils, or eosinophils structurally present in the affected area?", "Does the image show engagement or disruption of anatomical barriers such as the epithelial, endothelial, or mucosal barriers?"], "contexual_behavior": ["Does the image show evidence of a process that becomes exaggerated during allergic responses involving IgE and mast cell degranulation?", "Is there an indication that a reaction may be absent after antigen exposure due to prior immune tolerance or desensitization?", "Can you identify features suggesting a delayed response possibly caused by immunosuppressive therapy inhibiting mast cell or basophil activation?", "Is there visual evidence of intensified immune activity that could be linked to autoimmunity and abnormal self-antigen recognition?", "Does the image suggest a decreased immune response that might be associated with aging or immunosenescence?", "Is there any indication of impaired immunity or mast cell dysfunction that could be seen in immunodeficient patients?", "Can you observe signs of increased reactivity following repeated exposure to the same allergen, possibly due to sensitization or memory cell activation?", "Does the image suggest a rapid resolution of a reaction, potentially due to anti-inflammatory therapy suppressing mediator release?", "Is there evidence of heightened severity in individuals with atopy and elevated IgE levels?", "Can you see signs of reduced reactivity that might result from desensitization therapy or allergen immunotherapy?", "Does the image indicate altered immune cell activation or mediator release that could occur during acute infection?", "Is there any visual cue of decreased effectiveness of a response that might be due to chronic stress and immunosuppression?", "Can you detect signs of exacerbated inflammation potentially triggered by environmental pollutants?", "Is there evidence of a reduced response that could be attributed to antihistamine use and histamine receptor blockade?", "Does the image suggest a pronounced reaction that may be associated with mast cell disorders and excessive mast cell activation?"], "functions": ["Does the image show evidence of a rapid physiological or immune response to an external stimulus?", "Can you identify signs of a defense mechanism that acts quickly to protect against threats?", "Is there visual evidence of immune cells or mediators being rapidly mobilized to a site of infection or injury?", "Does the image display features consistent with innate immunity or early immune defense?", "Can you see signs of a rapid onset of symptoms following exposure to a potential allergen?", "Is there evidence of processes such as vasodilation or increased vascular permeability in the tissue?", "Does the image suggest leukocyte recruitment to a site of inflammation or injury?", "Can you identify features associated with pathogen elimination or acute inflammation?", "Is there visual indication of degranulation or mediator release from immune cells?", "Does the image show signs of histamine release or cytokine production?", "Can you see evidence of complement activation in the tissue?", "Is there a rapid influx of immune cells or increased local blood flow visible, suggesting acute inflammation or edema?", "Does the image show features of a rapid, exaggerated immune response to a harmless antigen?", "Can you identify signs of an IgE-mediated allergic reaction, such as mast cell activation?", "Is there evidence of tissue protection or initiation of healing processes following injury?", "Does the image suggest the release of chemical mediators like histamine, prostaglandins, or cytokines from immune cells?", "Can you see features that indicate signal amplification in an immune response?", "Is there visual evidence of an acute immune response containing a threat and activating further immune mechanisms?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a lesion where calcifications are rare or absent?", "Does the image show a mass with a yellow to yellow-white coloration?", "Can you see a mass with moderate water content suggested by its appearance?"], "relational": ["Is there a mass containing stromal or connective tissue visible?", "Does the image show a structure associated with the reproductive system?", "Is there a structure interacting with ovarian follicles, corpus luteum, or the surface epithelium?"], "contexual_behavior": ["Is there evidence of a structure whose growth rate could be influenced by elevated gonadotropin levels or hormone therapy?", "Does the image show a structure that could play a role in endometrial stimulation through high levels of estrogen secretion?", "Does the image contain a structure whose functional activity might be decreased following chemotherapy?"], "functions": ["Is there evidence of a tumor that may cause estrogen overproduction?", "Can you identify a lesion that could be responsible for increased steroid hormone secretion, especially estrogen?", "Can you identify features consistent with endometrial hyperplasia or thickening, possibly due to increased estrogen levels?"]}}, "neutrophils": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show any round cells with a nucleus divided into multiple connected lobes?", "Can you identify cells that are approximately 10 to 12 micrometers in diameter?", "Are there cells present that contain granules within their cytoplasm?", "Is there evidence of cells with a pale pink cytoplasm and a dark purple-blue nucleus when stained?", "Can you see any cells whose nucleus appears to have 2 to 5 lobes?", "Are there structures that could represent about 50% to 70% of the white blood cells in the sample?", "Does the image include cells that might contain enzymes such as myeloperoxidase or elastase?", "Can you find cells with granules rich in proteins like lactoferrin or defensins?", "Are there cells whose average size or volume could be estimated at around 300 to 400 femtoliters?", "Is it possible to observe cells with a density close to 1.08 grams per milliliter?", "Can you identify cells that typically have a lifespan of only a few hours in the bloodstream?", "Are there cells present that could account for a normal count of 1,500 to 8,000 per microliter in human blood?", "Does the image show cells that might have an intracellular pH in the range of 7.0 to 7.4?", "Can you see any cells whose cytoplasm contains both granules and glycogen?"], "relational": ["Does the image show a component of the immune system?", "Can you identify cells present in blood or connective tissue?", "Is there evidence of cells located within inflamed or infected tissue?", "Does the image include structures produced in the bone marrow?", "Are there cells that might be found alongside monocytes, eosinophils, or basophils?", "Can you see elements that interact with lymphocytes or other leukocytes?", "Is there a structure associated with blood components such as plasma, red blood cells, or platelets?", "Does the image show cells that could be transported by blood vessels or lymphatic vessels?", "Are there cells migrating toward damaged or infected tissue in the image?", "Can you identify a subtype of white blood cell in the image?", "Is there evidence of cells present in body fluids like pus, synovial fluid, or cerebrospinal fluid?"], "contexual_behavior": [], "functions": ["Does the image show cells involved in engulfing and destroying invading microorganisms?", "Can you identify cells that mediate inflammation by migrating to affected tissues?", "Is there evidence of cells releasing inflammatory mediators such as cytokines or chemokines?", "Does the image contain cells that perform phagocytosis and lysosomal degradation of pathogens or debris?", "Are there cells present that contribute to wound healing by clearing microbes and dead cells?", "Can you see cells that might be releasing growth factors to promote tissue repair?", "Is there evidence of degranulation, such as the release of antimicrobial peptides or proteases?", "Do you observe cells that could be producing reactive oxygen species for microbial killing?", "Are there cells that respond to chemotactic signals and adhere to the endothelium at sites of infection?", "Can you identify cells that interact with other immune cells by modulating immune responses?", "Is there evidence of rapid accumulation of cells at a site of bacterial infection?", "Do you see cells forming extracellular traps composed of chromatin and granular proteins?", "Are there cells present that participate in early defense and rapid recruitment during acute inflammation?", "Can you observe any signs of tissue damage that could be caused by the release of proteolytic enzymes or reactive oxygen species?", "Is there evidence of cells clearing tissue fragments and dead cells as part of tissue cleanup?"]}, "no_questions": {"contexual_properties": ["Is there evidence of altered perfusion in the lung, such as disrupted blood flow patterns due to tumor growth?", "Can you identify regions of increased vascularity within the lung, which may result from angiogenesis associated with tumor growth?", "Can you see a reduction in the size of a lung mass, suggesting a therapeutic response or tumor regression?"], "properties": ["Can you identify nodules whose estimated volume falls between 0.1 and 50 cubic centimeters?", "Do any lesions appear to have a firm or rubbery texture based on their visual characteristics?", "Are there signs of increased mitotic activity, such as regions with a high density of dividing cells?"], "relational": ["Is there tissue present that resembles alveolar or bronchial epithelium along with abnormal masses?", "Does the image show a region near the heart or ribs?", "Does the image contain a structure that is part of the respiratory system?"], "contexual_behavior": ["Is there evidence of tissue that might be less responsive to targeted therapies, possibly due to visible heterogeneity or abnormal growth patterns?", "Does the image reveal areas with suppressed local immune surveillance, such as accumulation of regulatory immune cells?", "Are there features indicating enhanced invasive behavior, such as irregular borders or signs of epithelial-mesenchymal transition?"], "functions": ["Does the image show signs of fluid imbalance, such as pleural effusion or pulmonary edema?", "Does the image show features that could indicate impaired tissue repair or evasion of immune surveillance?", "Can you see any structures that might facilitate further dissemination of cancer cells to other organs?"]}}}
[ { "answer": "electron micrograph", "extracted_concepts": [ "electron micrograph" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "electron micrograph" ], "question": "does this image show electron micrograph?" }, { "answer": "no", "extracted_concepts": [ "electron micrograph", "esophagus" ], "question": "does esophagus show electron micrograph?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "hematologic" ], "question": "is hematologic present?" }, { "answer": "no", "extracted_concepts": [ "cranial artery" ], "question": "is cranial artery present?" }, { "answer": "thymus", "extracted_concepts": [ "thymus" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "thymus" ], "question": "is thymus present?" }, { "answer": "no", "extracted_concepts": [ "fracture" ], "question": "is fracture present?" }, { "answer": "thymoma", "extracted_concepts": [ "thymoma" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "thymoma" ], "question": "is thymoma present?" }, { "answer": "no", "extracted_concepts": [ "malignant adenoma" ], "question": "is malignant adenoma present?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" }, { "answer": "thymus", "extracted_concepts": [ "thymus" ], "question": "what is present?" }, { "answer": "thymoma", "extracted_concepts": [ "thymoma" ], "question": "what is present?" } ]	["esophagus", "electron micrograph", "malignant adenoma", "cranial artery", "fracture", "thymoma", "hematologic", "thymus"]	{"esophagus": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a muscular, cylindrical tube with a diameter of about 2 to 3 centimeters?", "Can you identify a structure that is approximately 25 to 30 centimeters in length in adults?", "Is there a tubular structure with a wall thickness of about 3 to 4 millimeters?", "Does the image contain a lining that appears pale pink and smooth?", "Can you see a moist, smooth surface consistent with a mucosal lining?", "Is there a structure composed of both skeletal muscle in its upper portion and smooth muscle in its lower portion?", "Does the image show a tube with distinct layers, such as mucosa, submucosa, muscularis propria, and adventitia?", "Can you identify a structure that contains stratified squamous epithelial cells and smooth muscle cells?", "Is there evidence of a moderate vascular network, such as submucosal capillaries, within a tubular structure?", "Does the image suggest the presence of a high density of nerve fibers in the myenteric or submucosal plexuses?", "Can you see a structure whose average weight would be about 25 to 30 grams?", "Is there a tubular organ with a water content of approximately 70 to 75 percent by weight?", "Does the image show a structure with collagen making up about 15 to 20 percent of its dry weight?", "Is there evidence of elastic fibers comprising around 2 to 5 percent of the dry weight in a tubular structure?", "Can you identify a structure with a moderate amount of glycogen in its epithelial lining?", "Does the image show a tubular organ with low lipid content, mainly in cell membranes?", "Is there a structure whose density would be close to 1.05 grams per cubic centimeter?", "Can you see a tubular organ whose temperature would be similar to core body temperature, around 36 to 37 degrees Celsius?", "Does the image contain a structure with a pH typically between 4 and 7?"], "relational": ["Does the image show a structure that is part of the digestive system?", "Can you identify a tubular structure that connects the pharynx to the stomach?", "Is there an object that passes through the neck, thorax, and upper abdomen?", "Does the image contain a structure composed of mucosal, submucosal, muscular, and connective tissue layers?", "Can you see a structure that is surrounded by the trachea, aorta, or vertebral column?", "Is there an object that receives blood supply from the inferior thyroid artery, bronchial arteries, or left gastric artery?", "Does the image show a structure innervated by the vagus nerve or the sympathetic trunk?", "Can you identify a region where the pharynx transitions into a sphincter at the upper end of a tubular structure?", "Is there a visible junction where a tubular structure meets the stomach, forming a lower sphincter?", "Does the image display a wall with distinct layers such as mucosa, submucosa, muscularis propria, and adventitia?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that serves as a conduit for transporting food or liquids from the throat to the stomach?", "Can you identify an anatomical feature that advances ingested material toward the stomach through wave-like muscular contractions?", "Does the image show a region where peristalsis might occur to move a swallowed bolus?", "Is there evidence of a barrier that could prevent stomach contents from moving back toward the throat?", "Can you see a structure that would coordinate with both the pharynx and the stomach during the process of eating?", "Is there an anatomical feature that could help protect the airway during swallowing by working in conjunction with the epiglottis?", "Does the image contain a region that would facilitate the passage of both liquids and solids by adjusting muscular activity?", "Can you identify a structure whose motility might be regulated by the enteric nervous system or autonomic input?", "Is there any indication of tissue that could respond to irritation with inflammation or increased mucus production?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show tubular structures connecting to a larger organ at the uterine cornua?", "Is there an organ located adjacent to the bladder or rectum?", "Is there an organ located within the pelvic cavity?"], "contexual_behavior": [], "functions": ["Does the image contain a structure responsible for expelling menstrual blood and tissue?", "Is there an organ whose structural and functional changes are regulated by reproductive hormones?", "Does the image contain a structure that provides a protective environment for fetal growth?"]}}, "electron micrograph": {"yes_questions": {"contexual_properties": ["Does the image show areas of increased cellular density that could indicate cellular hyperplasia or tissue compaction?", "Can you identify swollen organelles that might suggest cellular injury or osmotic imbalance?", "Is there evidence of disrupted membrane structure consistent with necrosis or severe membrane damage?", "Does the image display abnormal inclusions that could be associated with lysosomal storage disorders or protein aggregation?", "Are there visible changes in mitochondrial size that might reflect mitochondrial dysfunction or metabolic stress?", "Can you observe altered chromatin patterns that could be related to apoptosis or neoplastic transformation?", "Is there increased vacuolization that may indicate autophagy or cellular degeneration?", "Does the image reveal loss of cell junctions that could be due to epithelial injury or inflammation?", "Are thickened basement membranes present, as seen in chronic diabetes or glomerulopathies?", "Can you detect decreased granule content that might suggest secretory cell exhaustion or degranulation?", "Is there evidence of fragmented cellular structures that could result from apoptosis or necrosis?", "Does the image show increased lipid droplets that may be associated with steatosis or metabolic syndrome?", "Can you see alterations in the nuclear envelope that might indicate laminopathies or viral infections?", "Are there changes in cytoskeletal organization that could be related to cell migration or cytoskeletal disorders?", "Does the image display abnormal extracellular matrix composition as seen in fibrosis or connective tissue diseases?", "Is there an increase in autophagic vesicles that could suggest nutrient deprivation or neurodegenerative diseases?", "Can you observe loss of organelle integrity that may be due to advanced cell injury or toxic exposure?", "Are there changes in synaptic vesicle number that could reflect synaptic plasticity or neurodegenerative conditions?", "Does the image show altered cell size that might indicate hypertrophy or atrophy?", "Is there an increase in electron-dense deposits that could be associated with amyloidosis or mineralization disorders?"], "properties": ["Can you identify an image where the smallest distinguishable distance between two points is in the nanometer range?", "Does the image appear to be highly enlarged, possibly by factors between 1,000x and 1,000,000x?", "Is there evidence that the area captured in the image could range from a few square micrometers to several square millimeters?", "Can you assess whether the difference in intensity between features suggests influence from staining or imaging conditions?", "Does the image display a range of gray shades that might correspond to 8-bit or 16-bit grayscale depth?", "Can you infer whether each pixel represents a physical dimension measured in nanometers per pixel?", "Is there any indication of the digital format used to store this image, such as TIFF, JPEG, or PNG?", "Does the image have a horizontal dimension that could be in the range of hundreds to thousands of pixels?", "Can you estimate if the vertical dimension of the image is also within hundreds to thousands of pixels?", "Is there a visible marked segment indicating a real-world distance, such as a scale bar in nanometers or micrometers?", "Can you determine if the average intensity of the image suggests a particular level of brightness adjustment?", "Does the image show signs of random variation in pixel values that could indicate a certain signal-to-noise ratio?", "Can you infer the proportional relationship between the width and height of the image, such as a specific aspect ratio?", "Is it possible to estimate the number of bits used to represent each pixel in the image data?", "Can you deduce the duration the specimen was exposed to the imaging beam, possibly measured in milliseconds or seconds?"], "relational": ["Does the image provide a view of biological structures such as cell membranes or organelles?", "Can you identify features characteristic of macromolecular complexes?", "Is there evidence of epithelial cells, muscle tissue, or neurons being visualized?", "Does the image reveal organelles like mitochondria, endoplasmic reticulum, Golgi apparatus, or a nucleus?", "Can you observe anatomical relationships such as organelle proximity or membrane interactions?", "Are cell junctions or subcellular interfaces visible in the image?", "Does the image show subcellular components such as ribosomes, elements of the cytoskeleton, or vesicles?", "Can you determine if the sample includes molecular assemblies, organelles, whole cells, or tissue sections?", "Is there detailed visualization of fine structural features or organelle organization?", "Does the image highlight differences in membrane morphology, internal cristae, or granular density among organelles?", "Are cell boundaries or organelle architecture clearly depicted?", "Can you see evidence that the sample was prepared as a thin tissue section, cultured cell, or isolated organelle?"], "contexual_behavior": ["Does the image show evidence of cellular ultrastructure loss that could result from sample preparation artifacts such as shrinkage or distortion?", "Can you observe enhanced contrast in the image that might indicate the use of heavy metal staining techniques?", "Is there a noticeable decline in resolution that could be attributed to low voltage conditions during imaging?", "Does the visualization of subcellular components appear impaired, possibly due to fixation errors affecting preservation?", "Can you identify enhanced detail in areas that suggest the sample was dehydrated to reduce water interference?", "Is there any indication of sample damage or altered imaging function that could result from high electron beam intensity?", "Does the image show obscured or poorly defined viral particles that might be due to sample degradation?", "Can you see improved distinction of membrane structures that would be consistent with cryo-fixation preserving native ultrastructure?", "Is there a loss of clarity in protein complexes that could be explained by beam-induced damage during imaging?", "Does the morphology or contrast of organelles appear altered in a way that suggests the influence of different embedding media?"], "functions": ["Does the image provide a high-resolution view that reveals ultrastructural details of biological material?", "Can you identify organelles or macromolecular complexes not typically visible with light microscopy?", "Is there evidence of cellular processes or subcellular features that indicate detailed study of cell biology?", "Does the image show the morphology or spatial organization of organelles, allowing for functional analysis?", "Can you observe dynamic changes in cell structure, such as organelle rearrangement or membrane remodeling?", "Is there visible tissue architecture or specialized structures that suggest assessment of cell-to-cell interactions?", "Does the image reveal molecular organization or features that could indicate pathological alterations?", "Can you detect ultrastructural abnormalities, such as organelle damage or compromised membrane integrity, that might signal a cellular response to disease or injury?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a lack of clustering among tumor cells, with most appearing as single, isolated units?", "Does the image show cells within epithelial, connective, or lymphatic tissues that appear individually dispersed rather than clustered?", "Does the image show tumor cells interacting with the tumor stroma, immune cell niches, or extracellular matrix?"], "contexual_behavior": [], "functions": ["Can you identify cells that might be resisting cell death, such as those surviving in detached or stressful environments?", "Are there visually distinct cell populations suggesting phenotypic diversity or genetic variability within the tumor mass?", "Do you see cells that could be facilitating tissue invasion by detaching from a main tumor?"]}}, "malignant adenoma": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion that could be present in the endocrine, digestive, or respiratory system?", "Is there a mass affecting glandular epithelium or mucosal tissue?", "Can you identify an area composed of neoplastic epithelial cells along with stromal or inflammatory cells?", "Is there a structure adjacent to connective tissue, blood vessels, or neighboring organs that appears abnormal?", "Does the image contain a suspicious mass within the adrenal gland, colon, thyroid, or lung?", "Can you see evidence of tissue invasion, fibrosis, or a stromal reaction near a lesion?", "Is there a visible association between a mass and regional lymph nodes or lymphatic capillaries?", "Are there arterioles, capillaries, or venules supplying a suspicious area in the image?", "Can you identify a boundary such as a tumor capsule, invasion front, or adjacent normal tissue around a lesion?", "Is there an abnormal structure located within the abdominal cavity, thoracic cavity, or neck region?"], "contexual_behavior": [], "functions": ["Does the image show a structure exhibiting signs of uncontrolled cell proliferation or continuous cell division?", "Can you identify an area where tissue appears to invade or infiltrate adjacent structures?", "Is there evidence of abnormal tissue replacing healthy organ architecture, potentially impairing normal function?", "Does the image contain features suggestive of local tissue invasion or degradation of the extracellular matrix?", "Can you see any indication of new blood vessel formation that might be driven by pro-angiogenic factors?", "Is there a region that could be associated with metastatic spread, such as cells appearing to enter blood vessels or lymphatics?", "Does the image show signs of inflammation or changes in the local tissue environment, such as matrix remodeling or altered stromal cell behavior?", "Can you identify a structure that might be disrupting hormone production or regulation, possibly through ectopic hormone production?", "Is there visual evidence of altered cellular signaling, such as abnormal growth patterns or loss of normal tissue boundaries?", "Does the image suggest resistance to cell death, for example by showing densely packed cells with little evidence of apoptosis?", "Can you see features that might indicate immune evasion, such as lack of immune cell infiltration in abnormal tissue regions?", "Is there evidence of a pro-tumorigenic inflammatory response, such as the presence of recruited immune cells or cytokine-mediated changes in the tissue?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you identify a mass involving breast epithelium, ductal tissue, or stromal tissue?", "Is there evidence of tumor involvement near breast lobules, ducts, pectoral muscles, or the skin?", "Can you see any indications of metastatic spread to the lungs, liver, brain, or bones?"], "contexual_behavior": [], "functions": ["Can you see disruption of normal tissue architecture or invasion into surrounding tissues, suggesting impairment of organ function?", "Can you observe signs of new blood vessel formation or increased vascularization, possibly due to secretion of pro-angiogenic factors like VEGF?", "Is there visual evidence of tumor cells displaying increased motility, intravasation into blood vessels, or colonization of distant organs, indicating metastatic potential?"]}}, "cranial artery": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the circulatory system within the head?", "Can you identify a vessel supplying blood to regions such as the scalp, meninges, brain, or face?", "Is there a blood vessel that could originate from the internal or external carotid artery, or the vertebral artery?", "Does the image contain a vessel that gives rise to branches like the middle meningeal artery or the ophthalmic artery?", "Can you see any veins, such as cerebral veins or meningeal veins, that are associated with arteries in the cranial region?", "Is there a vessel located near cranial bones such as the skull, temporal bone, or sphenoid bone?", "Does the image show a structure providing blood to brain tissue, scalp, dura mater, or facial muscles?", "Can you identify a vessel responsible for supporting the metabolic needs of the brain?", "Is there a structure that is protected by the skull or meninges?", "Does the image show a vessel forming connections with other arteries, such as those in the Circle of Willis or the facial artery?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for delivering arterial blood to the brain?", "Can you identify a vessel involved in supplying oxygen and nutrients to cranial tissues?", "Is there evidence of an arterial network that forms part of the Circle of Willis?", "Does the image contain a structure that regulates cerebral blood flow by adjusting its diameter?", "Can you see a vessel that helps maintain consistent perfusion and supports brain homeostasis?", "Is there a structure that responds to changes in blood pressure through mechanisms like myogenic responses?", "Does the image show a vessel contributing to waste removal via the blood-brain barrier and venous return?", "Can you identify a structure that supports neural activity by providing glucose and oxygen for synaptic transmission?", "Is there a vessel visible that participates in thermoregulation by modulating blood flow within the brain?", "Does the image contain a structure that could initiate collateral circulation to protect brain tissue during ischemia?"]}, "no_questions": {"contexual_properties": ["Does the image depict tissue where a protein is not overexpressed or is absent, resulting in a negative status?", "Is there a region where the immunohistochemistry score for a certain receptor would be classified as 0 or 1+ according to clinical guidelines?", "Is there an absence of signal in fluorescence in situ hybridization, with a HER2/CEP17 ratio below the amplification cutoff?"], "properties": ["Does the image show a sample with a HER2/CEP17 ratio less than 2.0?", "Does the image show a tissue sample with absent or very low levels of a certain receptor protein overexpression?", "Does the image show a case that meets the diagnostic criteria for negativity based on IHC \u22641+ or FISH ratio <2.0?"], "relational": ["Is there a tumor mass present in the image that could be relevant for evaluating a receptor status?", "Is there a tumor located in the breast, stomach, or esophagus that could be tested for a specific protein's absence?", "Does the image contain epithelial tumor cells or carcinoma cells that might be assessed for receptor expression?"], "contexual_behavior": ["Can you identify a tumor that might exhibit slower cell proliferation due to the absence of HER2-driven signaling?", "Does the tumor microenvironment show diminished angiogenesis, possibly due to reduced HER2-driven pro-angiogenic signaling?", "Is there evidence that anti-apoptotic pathways are not strongly activated in the tumor, suggesting impaired HER2-mediated cell survival?"], "functions": ["Does the image suggest a tumor with reduced ability to evade apoptosis due to the absence of survival signaling from a specific receptor?", "Is there visual evidence of altered cell cycle regulation, indicating that cell division is less influenced by a specific signaling pathway?", "Is there a tumor present that would likely not respond to therapies targeting a specific receptor, such as trastuzumab?"]}}, "fracture": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any disruption in the continuity of a structure belonging to the skeletal system?", "Is there evidence of structural damage affecting bones such as the radius, femur, or clavicle?", "Can you identify an area where the periosteum or surrounding soft tissue appears altered or disrupted?", "Does the image reveal changes in tissues like muscle, ligament, tendon, or skin near a bony structure?", "Is there a visible abnormality adjacent to joints such as the knee, elbow, or wrist?", "Can you see any features suggesting involvement of blood vessels like the radial or femoral artery near a damaged area?", "Does the image indicate possible impact on nerves such as the radial or sciatic nerve in the vicinity of a bony abnormality?", "Is there a region, such as the forearm, hip, or spine, that appears particularly susceptible to structural disruption?", "Can you observe any changes in connective tissues like ligaments, tendons, or cartilage near a site of bone discontinuity?", "Does the image suggest involvement of the muscular, circulatory, or nervous system in association with a skeletal abnormality?"], "contexual_behavior": ["Does the image show evidence of a bone injury that might heal more slowly if there is reduced blood supply to the area?", "Is there a bone disruption that could fail to unite properly in the presence of infection or tissue necrosis?", "Can you identify a bone injury whose healing might be delayed in a patient with diabetes mellitus?", "Does the image suggest a bone injury in a young individual where rapid healing and robust bone regeneration are expected?", "Is there a bone lesion that could demonstrate impaired callus formation if the patient is malnourished?", "Can you see a bone injury that might fail to remodel correctly in the context of osteoporosis or decreased bone density?", "Is there a bone disruption whose healing process could be slowed by corticosteroid use due to osteoblast suppression?", "Does the image show a bone injury that might exhibit abnormal healing in a smoker due to reduced vascularity?", "Is there a bone injury that could show increased bone resorption during immobilization or disuse?", "Can you identify a bone lesion that might demonstrate enhanced healing after physical or electrical stimulation therapy?", "Does the image suggest a bone injury in an elderly patient where restoration of mechanical strength may be reduced?", "Is there a bone disruption whose healing process could be altered by repeated mechanical stress or micro-movements?", "Can you see a bone injury located in an avascular region where impaired vascularization might lead to poor healing?", "Does the image show a bone lesion that could demonstrate altered healing in the presence of systemic inflammation?", "Is there a bone injury whose repair process might be compromised after exposure to radiation due to cellular and vascular damage?"], "functions": ["Does the image show evidence of disruption in the continuity of a bone structure?", "Is there visual indication of swelling or edema near a skeletal element?", "Can you identify signs of hematoma formation or localized bleeding adjacent to bone tissue?", "Does the image reveal any features suggestive of impaired mobility or instability in a limb or joint?", "Is there evidence of soft tissue injury, such as damage to muscles, ligaments, or nerves, near a bony structure?", "Can you observe any changes that might indicate an inflammatory response, such as increased tissue density or redness around a bone?", "Is there visual evidence of callus formation or new bone growth at a site of bone disruption?", "Does the image suggest loss of normal anatomical alignment or function in a skeletal region?", "Can you see any signs that might correspond to increased metabolic activity or tissue regeneration at a site of injury?", "Is there indication of vascular injury, such as disrupted blood vessels or localized ischemia, near a bone?", "Does the image show features that could be associated with the recruitment of immune cells, such as localized swelling or tissue infiltration?", "Can you identify any structural changes that might result from bone remodeling or repair processes?", "Is there evidence of pain response, such as guarding posture or tissue sensitization, in the affected area?"]}, "no_questions": {"contexual_properties": ["Does the image show a lesion that appears to have increased in size, suggesting active cell proliferation?", "Does the image show calcified regions within the mass, possibly due to dystrophic mineralization in necrotic areas?", "Is there a structure with prominent blood vessels, suggesting increased vascularization due to angiogenesis?"], "properties": ["Do most cells contain one to two small, inconspicuous nucleoli?", "Is necrosis minimal or absent in the tissue sample?", "Is cytoplasmic granularity minimal, with smooth cytoplasm predominating in the cells?"], "relational": ["Can you identify anatomical boundaries such as tumor margins or signs of invasion depth?", "Does the image display cells with features of malignant glandular epithelial cells?", "Are blood vessels visible near or within the abnormal area?"], "contexual_behavior": ["Is there evidence of decreased sensitivity to targeted therapies, potentially due to resistance mutations or alternative signaling pathways?", "Is there evidence of resistance to immune cell-mediated destruction, such as overexpression of immune checkpoint molecules?", "Is there evidence of increased production of immunosuppressive cytokines within the tumor microenvironment?"], "functions": ["Can you observe signs of angiogenesis, such as the presence of newly formed blood vessels?", "Is there evidence of apoptosis resistance, such as densely packed cells with minimal signs of cell death?", "Can you identify areas where glandular differentiation appears abnormal or where healthy glandular tissue is replaced?"]}}, "thymoma": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a mass in the image that measures between 2 and 10 centimeters at its largest dimension?", "Can you identify a structure whose weight could plausibly range from 20 to 200 grams?", "Does the image show a lesion that appears round, oval, or lobulated in shape?", "Is there a mass with a gray-white or tan coloration visible?", "Can you see a structure that might be composed of both epithelial cells and lymphocytes?", "Is there evidence of a lesion containing thymic epithelial cells and immature T lymphocytes?", "Does the tissue in question appear to have a low mitotic rate, with fewer than 2 mitoses per 10 high-power fields?", "Is there a region where the nuclear grade of the cells appears low to intermediate?", "Can you observe an area with moderate to high cellularity depending on the subtype?", "Is there a structure where the ratio of lymphocytes to epithelial cells seems high, suggesting a lymphocyte-rich composition?", "Does the mass appear firm in texture based on visual or contextual cues?", "Is there minimal or absent necrosis within the lesion, or can you detect any areas of necrosis that might indicate a more aggressive type?", "Are there focal calcifications present within the mass, affecting approximately 10 to 40 percent of its area?", "Does the proliferation index, as indicated by Ki-67 staining, appear to be low (less than 10%) in the tissue?", "Can you see a well-defined capsule surrounding the mass, measuring between 1 and 3 millimeters thick?", "Is the water content of the structure consistent with that of soft tissues, approximately 70 to 80 percent by weight?", "Does the density of the mass appear similar to soft tissue, around 1.05 grams per cubic centimeter?", "Is there evidence that the lipid content within the lesion is low?", "Can you observe moderate collagen content, particularly in the capsule or fibrous septa of the mass?", "Does the lesion display moderate vascularity, with small blood vessels dispersed throughout?"], "relational": ["Does the image show a mass located within the anterior mediastinum?", "Is there a structure present that could compress or displace the heart, lungs, trachea, or esophagus?", "Can you identify a lesion adjacent to the pericardium, lungs, great vessels, or sternum?", "Does the image reveal a mass arising from or closely related to the thymus gland?", "Is there evidence of a lesion in proximity to the internal thoracic arteries, brachiocephalic veins, or superior vena cava?", "Can you see a structure that might involve the anterior mediastinal or paratracheal lymph nodes?", "Is there a mass composed of epithelial, lymphoid, or connective tissue?", "Does the image contain a lesion that could include thymic epithelial cells or lymphocytes?", "Is there a structure whose anatomical boundaries are defined by the sternum anteriorly, pericardium posteriorly, lungs laterally, thoracic inlet superiorly, and diaphragm inferiorly?", "Can you identify a mass associated with the immune or lymphatic system?"], "contexual_behavior": [], "functions": ["Does the image show a structure that could be associated with impaired immune function or increased risk of autoimmune diseases?", "Is there evidence of a lesion that might disrupt immune system regulation by altering thymic selection?", "Can you identify an abnormality that could interfere with T cell development or maturation?", "Does the image contain a mass that might create an abnormal thymic microenvironment affecting lymphocyte differentiation?", "Is there a structure that could compromise immune tolerance by allowing self-reactive T cells to escape into the periphery?", "Can you see a lesion that might facilitate the survival of autoreactive T cells and disrupt central tolerance?", "Does the image show a region where healthy thymic tissue appears to be replaced, potentially impairing T cell education?", "Is there evidence of altered antigen presentation or changes in thymic epithelial cells within the image?", "Can you identify a mass whose presence could lead to immunodeficiency or increased susceptibility to infections?", "Does the image reveal a structure that might reduce the output of functional T cells and compromise adaptive immunity?"]}, "no_questions": {"contexual_properties": ["Does the mass appear heterogeneous, with genetic or phenotypic diversity among cells?", "Does the image show increased expression of proliferation markers like Ki-67?", "Is there a region with increased cellular density and reduced stromal space?"], "properties": ["Is there moderate to abundant stromal tissue, possibly due to a desmoplastic reaction?", "Can you identify cells exhibiting moderate to marked atypia?", "Does the tissue display features consistent with moderate to poor differentiation, such as moderate to high histological grade?"], "relational": ["Does the image show a lesion affecting glandular epithelium or submucosal tissue?", "Are regional lymph nodes, lymphatic capillaries, or lymphatic ducts visibly involved near the lesion?", "Is there an abnormality located in the colon, breast, lung, pancreas, or prostate?"], "contexual_behavior": ["Does the image show increased extracellular matrix degradation, possibly due to the activity of matrix metalloproteinases or other remodeling enzymes?", "Does the image show a structure that could be increasing its invasive behavior due to epithelial-mesenchymal transition or exposure to pro-invasive cytokines?", "Can you identify changes in differentiation state that might be linked to hormonal changes or modulation of hormone receptor signaling pathways?"], "functions": ["Is there evidence of vascular or lymphatic invasion that could indicate potential for metastatic spread?", "Is there visual evidence of tissue invasion or local spread into surrounding structures?", "Does the image show evidence of malignant epithelial cells invading beyond the basement membrane and forming gland-like structures?"]}}, "hematologic": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image contain a sample composed of red blood cells, white blood cells, platelets, and plasma?", "Can you identify a specimen that typically appears red in color?", "Is there evidence of a fluid with a viscosity between 3 and 4 centipoise at 37\u00b0C?", "Does the image show a sample whose pH would be expected to fall between 7.35 and 7.45?", "Can you see a sample that might have a density around 1.050 to 1.060 g/mL?", "Is there a specimen that would normally be collected in a volume between 2 and 10 mL for analysis?", "Does the image include a sample that could be assessed for hemoglobin concentration in the range of 12.0\u201317.5 g/dL depending on sex?", "Can you identify a sample where the hematocrit value might be between 36% and 53%?", "Is there a structure that would be expected to have a red blood cell count within the typical range for males or females?", "Does the image show a specimen that could be evaluated for a white blood cell count between 4,000 and 11,000 cells/\u03bcL?", "Can you see a sample that would be expected to contain 150,000 to 450,000 platelets per microliter?", "Is there a sample present that could have a mean corpuscular volume (MCV) between 80 and 100 fL?", "Does the image include a specimen where the mean corpuscular hemoglobin concentration (MCHC) might be 32\u201336 g/dL?", "Can you identify a sample that could have a mean corpuscular hemoglobin (MCH) of 27\u201333 pg/cell?", "Is there a specimen that would be expected to have an iron level between 60 and 170 \u03bcg/dL?", "Does the image show a sample that could have a fasting glucose concentration of 70\u201399 mg/dL?", "Can you see a specimen with a protein content typically between 6 and 8 g/dL?", "Is there a sample that would be expected to have a sodium concentration of 135\u2013145 mmol/L?", "Does the image include a specimen where the potassium concentration might be 3.5\u20135.0 mmol/L?", "Can you identify a sample that could have a calcium concentration between 8.5 and 10.5 mg/dL?"], "relational": ["Does the image show any structures that are part of the circulatory or immune systems?", "Can you identify an organ such as the bone marrow, spleen, or thymus?", "Is there evidence of hematopoietic or lymphoid tissue present?", "Does the image contain cells like red blood cells, white blood cells, or platelets?", "Are there visible blood vessels, lymph nodes, or the heart in the image?", "Can you see anatomical features that participate in immunity, fluid balance, or cell production?", "Is there a body fluid such as blood, plasma, or serum depicted?", "Does the image include regions like the bone marrow, spleen, lymph nodes, or bloodstream?", "Are arteries, veins, or capillaries visible in the image?", "Can you identify organs that contribute to the formation of blood components, such as the bone marrow, liver, or spleen?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a process responsible for transporting oxygen in the body?", "Can you identify structures or cells involved in immune defense, such as those producing antibodies or performing phagocytosis?", "Is there visual indication of mechanisms that facilitate blood clotting, like platelet activation or fibrin formation?", "Does the image include features related to the production of blood cells, such as hematopoiesis occurring in bone marrow?", "Can you see evidence of waste removal from the blood, such as the transport of metabolic byproducts or carbon dioxide?", "Is there a visible indication of processes that help maintain pH balance, possibly through buffering by plasma proteins or hemoglobin?", "Does the image show a response to infection or injury, such as activation of leukocytes or the presence of inflammatory mediators?", "Can you identify features related to the regulation of bleeding, such as vasoconstriction or platelet plug formation?", "Is there evidence of nutrient transport in the bloodstream, such as the movement of glucose, amino acids, or lipids?", "Does the image display signs of inflammation, like the mobilization of leukocytes or acute phase proteins?", "Can you observe features that suggest maintenance of blood volume, such as regulation by plasma proteins or erythrocyte mass?", "Is there visual evidence of the removal of old or damaged blood cells, such as phagocytosis by macrophages in organs like the spleen or liver?"]}, "no_questions": {"contexual_properties": [], "properties": ["Are there intracellular features that could have a protein content exceeding 90% of their dry mass?", "Is there evidence of intracellular bodies that could contain misfolded or overexpressed proteins?", "Does the image show any intracellular structures that are between 0.2 and 2 micrometers in diameter?"], "relational": ["Are there visible features that could be classified as Lewy bodies, Negri bodies, Mallory bodies, or viral inclusions?", "Does the image show a subcellular structure within neurons or hepatocytes?", "Does the image display subcellular objects within the cytoplasmic matrix or nuclear matrix?"], "contexual_behavior": ["Can you identify structures that physically obstruct organelles or disrupt their normal activities during cellular stress?", "Are there structures whose number appears increased in regions showing oxidative damage or cellular stress?", "Are there accumulations that could indicate impaired lysosomal degradation, as seen in lysosomal storage disorders?"], "functions": ["Does the image show any intracellular bodies that may impair cell function if present in excess?", "Does the image show intracellular structures that could be sites of protein aggregation?", "Does the image show any signs of cellular protection mechanisms against proteotoxic stress?"]}}, "thymus": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure in the anterior superior mediastinum visible in the image?", "Can you identify an organ that is part of both the immune and endocrine systems?", "Does the image show a structure located near the heart, trachea, aorta, or lungs?", "Is there an object that receives blood supply from arteries such as the inferior thyroid or internal thoracic artery?", "Can you see a structure connected to mediastinal lymph nodes or efferent lymphatic vessels?", "Is there a visible organ composed of a cortex, medulla, and a connective tissue capsule?", "Does the image contain a structure that could include thymic epithelial cells or thymocytes?", "Can you identify an object drained by small veins leading to the left brachiocephalic vein?", "Is there a structure supported or surrounded by the pericardium, sternum, pleura, or great vessels?"], "contexual_behavior": ["Does the image show a structure that is more active in early childhood, supporting immune maturation?", "Can you identify an organ that decreases its activity and output of mature T cells after puberty?", "Is there evidence of a structure that may undergo involution or atrophy with aging?", "Does the image contain an organ whose function might be impaired in cases of congenital immunodeficiency or severe infection?", "Can you see a structure that could show increased activity or regeneration after injury, especially in young individuals?", "Is there an organ present that may exhibit reduced function or atrophy in response to chronic stress or elevated glucocorticoids?", "Does the image include a structure that could alter its output or central tolerance mechanisms in autoimmune diseases?", "Can you identify an organ that may decrease its role in central tolerance induction during aging or autoimmune conditions?", "Is there a structure that might show signs of atrophy or functional decline in the context of malnutrition?", "Does the image show an organ that could increase T cell export during infection to support the adaptive immune response?", "Is there a structure that may be affected by corticosteroid exposure, leading to atrophy and suppressed lymphocyte development?", "Can you see an organ that may fail to eliminate self-reactive T cells in certain genetic disorders or autoimmune diseases?", "Does the image contain a structure whose thymopoiesis might be modulated during acute infection?", "Is there evidence of an organ that could increase its activity following bone marrow transplantation to support immune reconstitution?", "Can you identify a structure that may show reduced hormone secretion in chronic illness, infection, or severe stress?"], "functions": ["Does the image show a structure involved in the maturation of T lymphocytes?", "Can you identify an organ that provides an environment for precursor cells to differentiate into functional T cells?", "Is there a structure present that facilitates the selection of thymocytes based on their response to self-antigens?", "Does the image contain an organ responsible for eliminating T cells that strongly react to self-antigens?", "Can you see a structure associated with the deletion or inactivation of autoreactive T cells before they enter peripheral circulation?", "Is there an object that promotes the differentiation of thymocytes into the regulatory T cell lineage?", "Does the image include a structure that helps prevent autoimmune responses by ensuring self-reactive T cells are eliminated or converted?", "Can you identify an organ that generates a diverse repertoire of T cells for adaptive immunity?", "Is there a structure present that selects functional T lymphocytes through both positive and negative selection processes?", "Does the image show an organ that produces na\u00efve T cells capable of developing into memory T cells after antigen exposure?"]}, "no_questions": {"contexual_properties": ["Can you identify evidence of tumor progression that might alter the receptor status from undetectable to detectable?", "Does the intensity of immunohistochemical staining suggest the use of improved detection methods, antigen retrieval techniques, or possible sample degradation?", "Can you see a decrease in the proportion of cells lacking these receptors, possibly due to clonal evolution or selective pressure from treatment?"], "properties": ["Is there evidence of coarse and irregular chromatin within the nuclei of tumor cells?", "Does the image show a tumor with absent or minimal estrogen receptor expression?", "Does the tumor display densely packed cells, indicating high cell density?"], "relational": ["Does the image include invasive ductal carcinoma cells that are negative for both ER and HER2?", "Is there a sample from the female reproductive system, specifically the breast, where both ER and HER2 are not detected?", "Is there evidence of a breast tumor where neither the nuclei nor the cell membranes of the tumor cells display ER or HER2 positivity?"], "contexual_behavior": ["Is there evidence of a neoplasm that would not benefit from anti-ER or anti-HER2 targeted agents?", "Can you identify a tumor type with a higher risk of early recurrence after surgical intervention?", "Can you see evidence of a neoplastic lesion that might display increased immunogenicity or altered antigen presentation?"], "functions": ["Does the tumor appear to have characteristics associated with early relapse or a greater likelihood of metastasis to visceral organs or the central nervous system?", "Is there a visible indication of high proliferation, such as an elevated mitotic index or increased Ki-67 staining?", "Does the image show a tumor that lacks both estrogen receptor and human epidermal growth factor receptor 2 expression?"]}}}
[ { "answer": "neutrophils and basophil", "extracted_concepts": [ "basophil", "neutrophils" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "basophil", "neutrophils" ], "question": "does this image show neutrophils and basophil?" }, { "answer": "no", "extracted_concepts": [ "parathyroid", "basophil", "neutrophils" ], "question": "does parathyroid show neutrophils and basophil?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "hematologic" ], "question": "is hematologic present?" }, { "answer": "no", "extracted_concepts": [ "atherosclerosis" ], "question": "is atherosclerosis present?" }, { "answer": "blood", "extracted_concepts": [ "blood" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "blood" ], "question": "is blood present?" }, { "answer": "no", "extracted_concepts": [ "jejunum" ], "question": "is jejunum present?" }, { "answer": "leukocytes", "extracted_concepts": [ "leukocytes" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "leukocytes" ], "question": "is leukocytes present?" }, { "answer": "no", "extracted_concepts": [ "pituitary", "hyalin mass", "slides", "amyloid", "brain" ], "question": "is hyalin mass in pituitary which is amyloid there are several slides from this case in this file 23 yowf amyloid limited to brain present?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" }, { "answer": "blood", "extracted_concepts": [ "blood" ], "question": "what is present?" }, { "answer": "leukocytes", "extracted_concepts": [ "leukocytes" ], "question": "what is present?" } ]	["parathyroid", "hematologic", "pituitary", "basophil", "hyalin mass", "leukocytes", "jejunum", "neutrophils", "slides", "amyloid", "atherosclerosis", "brain", "blood"]	{"parathyroid": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a structure that is oval or bean-shaped and measures approximately 6 mm in length?", "Can you identify a yellowish-brown glandular structure with a soft, slightly firm texture?", "Is there a group of four small glands visible in the image?", "Does the image contain a structure that produces parathyroid hormone?", "Can you see a gland that contains both chief cells and oxyphil cells?", "Is there a structure whose average volume is around 30\u201340 cubic millimeters?", "Does the image show a gland with a weight of about 30\u201350 milligrams?", "Can you identify a structure with a water content of approximately 75\u201380% by weight?", "Is there a gland with a density close to 1.05 grams per cubic centimeter?", "Does the image include a structure with a protein content of about 15\u201320% of its wet weight?", "Can you see a gland with a lipid content of approximately 5\u20137% of its wet weight?", "Is there a structure whose phosphorus concentration is roughly 20\u201330 mg per 100 g of tissue?", "Does the image show a gland with a calcium concentration of about 100\u2013150 mg per 100 g of tissue?", "Can you identify a structure with a magnesium concentration of approximately 5\u20138 mg per 100 g of tissue?", "Is there a gland with an iron content of about 0.1\u20130.2 mg per 100 g of tissue?", "Does the image contain a structure whose normal pH is around 7.2\u20137.4?", "Can you see a gland that maintains a temperature close to 37\u00b0C?", "Is there a structure with a parathyroid hormone content of about 50\u2013100 micrograms per gram of tissue?"], "relational": ["Does the image show a structure that is part of the endocrine system?", "Can you identify small glands located near or on the posterior surface of the thyroid gland?", "Is there evidence of anatomical structures adjacent to the thyroid gland, trachea, or esophagus?", "Does the image include tissues supplied by the inferior or superior thyroid arteries?", "Can you see any structures in proximity to the recurrent or superior laryngeal nerves?", "Is there a region surrounded by the thyroid capsule or connective tissue?", "Does the image display features from the anterior neck region?", "Are there typically four small glands visible in association with the thyroid gland?", "Can you identify structures with lymphatic drainage to the deep cervical or paratracheal lymph nodes?"], "contexual_behavior": ["Is there a structure in the image that would increase hormone secretion to restore blood calcium levels during hypocalcemia?", "Can you identify an object that would suppress hormone release in response to elevated blood calcium (hypercalcemia)?", "Does the image show a gland that could fail to regulate calcium homeostasis in the context of chronic kidney disease?", "Is there a structure that, if affected by an adenoma, could cause hormone overproduction and result in hypercalcemia?", "Can you see a gland that might reduce its activity following thyroid surgery due to accidental removal or damage?", "Is there an object that would adjust its hormone output in response to vitamin D deficiency to compensate for decreased calcium absorption?", "Does the image contain a structure whose ability to sense and respond to serum calcium changes could be impaired by glandular damage or genetic defects?", "Can you identify a gland that would increase hormone output during pregnancy to meet higher calcium demands?", "Is there a structure that could become dysfunctional due to autoimmune destruction, resulting in impaired calcium regulation?", "Does the image show a gland that might exhibit reduced hormone secretion after exposure to radiation?", "Is there an object that would increase hormone production in response to magnesium deficiency?", "Can you see a structure whose regulatory function may decrease with aging due to cellular senescence?", "Is there a gland that could alter its hormone secretion in response to acute stress via neuroendocrine signaling?", "Does the image contain a structure that might fail to maintain phosphate balance in metabolic disorders such as chronic kidney disease?", "Is there an object that would increase hormone secretion to counteract decreased calcium uptake during chronic malabsorption?"], "functions": ["Is there a structure in the image that plays a key role in regulating calcium and phosphate levels in the body?", "Can you identify an object responsible for secreting a hormone that increases blood calcium by acting on bone, kidneys, and intestines?", "Does the image show a gland involved in stimulating bone resorption and releasing minerals into the bloodstream?", "Is there a structure that influences phosphate balance by promoting its excretion through the kidneys?", "Can you see an object that interacts with the kidneys to control mineral levels by enhancing calcium reabsorption and phosphate excretion?", "Is there a gland present that contributes to the activation of vitamin D by stimulating its conversion to calcitriol in the kidneys?", "Does the image contain a structure that responds to low blood calcium by increasing hormone secretion to restore normal levels?", "Can you identify an object that adjusts its hormone output in response to changes in serum calcium and phosphate concentrations?", "Is there a gland visible that helps maintain neuromuscular function by regulating calcium necessary for nerve and muscle activity?", "Does the image show a structure involved in maintaining electrolyte balance by controlling extracellular calcium and phosphate concentrations?"]}, "no_questions": {"contexual_properties": ["Can you identify vascular structures that appear altered or affected by extracellular material?", "Is there a visible indication of changes in blood vessel walls that could be associated with pathological processes?", "Does the image show any evidence of abnormal deposits within blood vessels?"], "properties": ["Does the image show deposits composed of misfolded protein fibrils arranged in beta-pleated sheet structures?", "Can you observe vessel wall deposits with moderate to high density?", "Can you identify deposits ranging from 1 to 10 micrometers in diameter?"], "relational": ["Does the image display abnormalities in regions like the cerebral cortex, leptomeninges, or occipital lobe?", "Is there evidence of interaction between affected vessels and structures such as perivascular spaces or astrocytic end-feet?", "Can you identify blood vessels containing endothelial cells, smooth muscle cells, or pericytes that appear abnormal?"], "contexual_behavior": ["Does the image show changes in blood vessels that could be associated with pathological protein accumulation?", "Is there evidence in the image of abnormal deposits within blood vessel walls?", "Can you identify any vascular structures that appear altered or affected by extracellular material?"], "functions": ["Is there visual evidence of cognitive impairment that could be linked to vascular changes?", "Can you see vessels with reduced reactivity, possibly due to endothelial or smooth muscle cell damage?", "Does the image display signs of vessel narrowing or obstruction that might indicate hypoperfusion?"]}}, "hematologic": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image contain a sample composed of red blood cells, white blood cells, platelets, and plasma?", "Can you identify a specimen that typically appears red in color?", "Is there evidence of a fluid with a viscosity between 3 and 4 centipoise at 37\u00b0C?", "Does the image show a sample whose pH would be expected to fall between 7.35 and 7.45?", "Can you see a sample that might have a density around 1.050 to 1.060 g/mL?", "Is there a specimen that would normally be collected in a volume between 2 and 10 mL for analysis?", "Does the image include a sample that could be assessed for hemoglobin concentration in the range of 12.0\u201317.5 g/dL depending on sex?", "Can you identify a sample where the hematocrit value might be between 36% and 53%?", "Is there a structure that would be expected to have a red blood cell count within the typical range for males or females?", "Does the image show a specimen that could be evaluated for a white blood cell count between 4,000 and 11,000 cells/\u03bcL?", "Can you see a sample that would be expected to contain 150,000 to 450,000 platelets per microliter?", "Is there a sample present that could have a mean corpuscular volume (MCV) between 80 and 100 fL?", "Does the image include a specimen where the mean corpuscular hemoglobin concentration (MCHC) might be 32\u201336 g/dL?", "Can you identify a sample that could have a mean corpuscular hemoglobin (MCH) of 27\u201333 pg/cell?", "Is there a specimen that would be expected to have an iron level between 60 and 170 \u03bcg/dL?", "Does the image show a sample that could have a fasting glucose concentration of 70\u201399 mg/dL?", "Can you see a specimen with a protein content typically between 6 and 8 g/dL?", "Is there a sample that would be expected to have a sodium concentration of 135\u2013145 mmol/L?", "Does the image include a specimen where the potassium concentration might be 3.5\u20135.0 mmol/L?", "Can you identify a sample that could have a calcium concentration between 8.5 and 10.5 mg/dL?"], "relational": ["Does the image show any structures that are part of the circulatory or immune systems?", "Can you identify an organ such as the bone marrow, spleen, or thymus?", "Is there evidence of hematopoietic or lymphoid tissue present?", "Does the image contain cells like red blood cells, white blood cells, or platelets?", "Are there visible blood vessels, lymph nodes, or the heart in the image?", "Can you see anatomical features that participate in immunity, fluid balance, or cell production?", "Is there a body fluid such as blood, plasma, or serum depicted?", "Does the image include regions like the bone marrow, spleen, lymph nodes, or bloodstream?", "Are arteries, veins, or capillaries visible in the image?", "Can you identify organs that contribute to the formation of blood components, such as the bone marrow, liver, or spleen?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a process responsible for transporting oxygen in the body?", "Can you identify structures or cells involved in immune defense, such as those producing antibodies or performing phagocytosis?", "Is there visual indication of mechanisms that facilitate blood clotting, like platelet activation or fibrin formation?", "Does the image include features related to the production of blood cells, such as hematopoiesis occurring in bone marrow?", "Can you see evidence of waste removal from the blood, such as the transport of metabolic byproducts or carbon dioxide?", "Is there a visible indication of processes that help maintain pH balance, possibly through buffering by plasma proteins or hemoglobin?", "Does the image show a response to infection or injury, such as activation of leukocytes or the presence of inflammatory mediators?", "Can you identify features related to the regulation of bleeding, such as vasoconstriction or platelet plug formation?", "Is there evidence of nutrient transport in the bloodstream, such as the movement of glucose, amino acids, or lipids?", "Does the image display signs of inflammation, like the mobilization of leukocytes or acute phase proteins?", "Can you observe features that suggest maintenance of blood volume, such as regulation by plasma proteins or erythrocyte mass?", "Is there visual evidence of the removal of old or damaged blood cells, such as phagocytosis by macrophages in organs like the spleen or liver?"]}, "no_questions": {"contexual_properties": ["Is there a part that appears softer, suggesting physiological changes related to ovulation or late pregnancy?", "Can you identify abnormal tissue growth that could suggest dysplasia, cancer, or chronic inflammation?", "Does the image reveal ulceration, which could result from severe infection, malignancy, or trauma?"], "properties": [], "relational": ["Is there a region that appears to receive blood supply from the uterine artery or the vaginal artery?", "Does the image include a region related to the lower uterine segment or the uterine body?", "Does the image show a structure that is part of the female reproductive system?"], "contexual_behavior": [], "functions": ["Can you identify an anatomical feature that facilitates the entry of sperm into the reproductive tract?", "Is there evidence of a mucus plug that could seal the uterine cavity to prevent infection during pregnancy?", "Does the image show a barrier that helps prevent pathogens from reaching the uterus?"]}}, "basophil": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a round cell in the image with an irregular or lobulated nucleus?", "Can you identify a cell that measures approximately 10 to 14 micrometers in diameter?", "Does the image show a cell with deep blue or purple granules when stained?", "Is there a cell present that contains large, coarse granules?", "Can you see a cell whose nucleus is bilobed or S-shaped and often obscured by granules?", "Is there a cell with pale cytoplasm filled with prominent basophilic granules?", "Does the image include a cell that constitutes less than 1% of the white blood cells?", "Can you identify a cell that is likely to contain histamine and heparin within its granules?", "Is there a cell present that expresses surface markers such as CD123, CD203c, or Fc\u03b5RI?", "Can you see a cell with a volume in the range of 120 to 160 femtoliters?", "Does the image show a cell with moderate RNA content, suggesting limited protein synthesis activity?", "Is there a cell whose granules may contain enzymes like histaminase, peroxidase, or proteases?", "Can you identify a cell with a typical lifespan of 1 to 3 days in circulation?", "Is there a cell in the image whose density would be expected to be between 0 and 100 per microliter of peripheral blood?", "Does the image show a cell that is part of the population with a normal count of 0 to 0.3 \u00d7 10^9 cells per liter in human blood?"], "relational": ["Does the image show a cell that is part of both the hematopoietic and immune systems?", "Is there a structure present in blood or connective tissue that could be involved in immune responses?", "Can you identify a cell type typically found in the buffy coat or peripheral blood?", "Does the image contain a cell that originates from the bone marrow?", "Is there evidence of a granulocyte lineage cell arising from a myeloid progenitor?", "Can you see a cell that is structurally related to eosinophils, neutrophils, or mast cells?", "Does the image include a structure that interacts with blood vessels or endothelial cells during inflammation?", "Is there a cell visible that circulates within the circulatory system and participates in immune surveillance?", "Can you identify a cell type that migrates to lymphatic tissues or lymph nodes during immune responses?"], "contexual_behavior": [], "functions": ["Does the image show a cell type involved in mediating inflammatory responses?", "Can you identify a structure that participates in immune regulation by releasing mediators?", "Is there a cell present that contributes to immune defense by attracting or activating other immune cells?", "Does the image contain a cell that plays a role in allergic reactions through the release of histamine?", "Can you see a cell that might undergo degranulation in response to immunoglobulin E (IgE) binding?", "Is there evidence of a cell type that helps defend against parasites by releasing cytotoxic granules?", "Does the image show a cell that promotes eosinophil recruitment?", "Can you identify a cell that regulates inflammation by secreting cytokines?", "Is there a cell present that modulates leukocyte activity?", "Does the image contain a cell involved in hypersensitivity reactions by amplifying IgE-mediated responses?", "Can you see a cell that interacts with T cells or eosinophils through cytokine signaling?", "Is there a cell present that produces interleukins such as IL-4 or IL-13 during immune responses?", "Does the image show a cell that modulates vascular permeability by releasing histamine or other vasoactive substances?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image contain cells with medium to large size and elevated mitotic activity?", "Is there visual indication of high proliferation rates among the cells?", "Can you identify cells that would likely have elevated RNA expression for basal markers?"], "relational": ["Can you see an epithelial layer lacking hormone receptor expression?", "Can you distinguish between luminal, squamous, and basal-like epithelial subtypes in the tissue?", "Is there a structure within the integumentary, respiratory, or reproductive system that appears to have regenerative properties?"], "contexual_behavior": [], "functions": ["Are there cells providing differentiation signals or serving as a source of new differentiated cells within the tissue?", "Does the image contain progenitor cells involved in regeneration of specialized epithelial cells?", "Is there evidence of a cell type supporting epithelial turnover and maintaining tissue homeostasis?"]}}, "leukocytes": {"yes_questions": {"contexual_properties": ["Does the image show an increased number of cells that might indicate infection or inflammation?", "Can you identify a decreased presence of certain cells that could suggest immunosuppression or aplastic anemia?", "Is there evidence of cells with increased size, possibly due to activation or malignancy?", "Do any cells appear to have altered shapes, which might be seen during migration or in hematologic disorders?", "Are there cells with increased granularity, as might occur in allergic reactions or chronic inflammation?", "Can you observe cells with reduced granularity, which could be associated with agranulocytosis or chemotherapy effects?", "Do any cells display abnormal morphology that might be seen in leukemia or severe infections?", "Is there an accumulation of specific cells within tissue areas, suggesting inflammation or granulomatous disease?", "Are there cells that show a change in staining color, possibly indicating toxic granulation or leukemia?", "Can you see cells with highly segmented nuclei, as might be found in megaloblastic anemia or myelodysplastic syndromes?", "Are there cells exhibiting cytoplasmic vacuolization, which could be a sign of sepsis or toxic states?", "Do any cells appear immature, potentially reflecting acute leukemia or bone marrow stress?", "Is there evidence of abnormal surface markers on certain cells, as seen in lymphoma or immunodeficiency disorders?", "Can you identify cells with increased volume, which may occur during activation or blast transformation?", "Are there cells with decreased volume, possibly due to chronic disease or post-chemotherapy changes?", "Do any cells appear unusually fragile, which might be observed in hereditary or autoimmune diseases?", "Are there cells containing inclusions, as could be seen in viral infections or May-Hegglin anomaly?", "Is there evidence of altered cellular composition, which might suggest leukemia or chronic infections?", "Do any cells display features of morphological activation, as would occur during an immune response?", "Can you observe abnormal aggregation of cells, which could indicate leukostasis or hyperviscosity syndromes?"], "properties": ["Does the image show cells whose count in blood would typically fall within the range of 4,000 to 11,000 per microliter?", "Can you identify cells that are approximately 10 to 15 micrometers in diameter?", "Are there round or irregularly shaped cells present, depending on their subtype?", "Does the image include cells with varying lifespans, from hours to years, based on their subtype?", "Can you see different types of blood cells such as neutrophils, lymphocytes, monocytes, eosinophils, or basophils?", "Are there cells present that contain cytoplasmic granules, as well as others that lack prominent granules?", "Does the image suggest a distribution where one cell type is most abundant, making up about 50\u201370% of the population, with others present in lower percentages?", "Can you observe cells with different nuclear-to-cytoplasmic ratios, such as some with a high ratio and others with a lower ratio?", "Are there cells that appear blue to purple when stained with Romanowsky-type stains?", "Does the image show cells that might contain cytoskeletal proteins, enzymes, membrane receptors, or immunoglobulins?", "Can you identify cells that would be expected to have about 6 picograms of DNA per diploid cell?", "Are there cells likely to express surface markers such as CD45, with additional markers like CD3, CD19, or CD14 depending on their type?", "Does the image include cells with a cytoplasmic volume in the range of 100 to 200 femtoliters, varying by subtype?", "Are there cells present that would separate at a density of around 1.08 g/mL in a Ficoll-Paque gradient?", "Can you see cells that might contain approximately 10 to 30 picograms of RNA, depending on their activation state and subtype?"], "relational": ["Does the image show any components of the immune system?", "Can you identify cells such as neutrophils or lymphocytes in the image?", "Is there evidence of monocytes, eosinophils, or basophils present?", "Does the image include tissue where blood cells are produced, such as bone marrow?", "Can you see an organ involved in cell maturation, like the thymus?", "Is there a visible layer or component corresponding to the buffy coat in blood?", "Does the image show structures where hematopoiesis might occur?", "Are there blood vessels or lymphatic vessels that could transport immune cells?", "Can you identify lymphatic organs such as lymph nodes or spleen interacting with immune cells?", "Is there an area of inflamed tissue where immune cells might accumulate?", "Does the image include lymph nodes where immune cells could be activated?"], "contexual_behavior": [], "functions": ["Does the image show cells that are involved in defending the body against pathogens?", "Can you identify elements that participate in immune surveillance by monitoring tissues for abnormal or foreign cells?", "Is there evidence of cells performing phagocytosis or engulfing microorganisms?", "Does the image contain cells that might be releasing cytokines or recruiting other immune cells at a site of inflammation?", "Can you see any indication of chemotaxis or migration of cells toward an area of tissue injury or infection?", "Are there cells present that could be involved in clearing debris or aiding tissue repair after injury?", "Does the image show structures that might be participating in allergic responses, such as releasing histamine or activating eosinophils?", "Can you identify cells that could be eliminating abnormal or cancerous cells through cytotoxic activity?", "Is there visual evidence of antibody production or humoral immunity, possibly involving B lymphocytes?", "Are there cells that appear to be regulating immune responses, potentially through cytokine secretion or suppressive activity?", "Does the image show cells migrating through blood vessel walls into affected tissues (diapedesis or extravasation)?", "Can you see interactions between immune cells that might indicate cell-cell communication or antigen presentation?", "Is there evidence of an inflammatory response that could be due to autoimmune activity, such as cells targeting the body\u2019s own tissues?", "Are there cells actively removing dead cells or apoptotic bodies as part of tissue cleanup?", "Does the image suggest a response to vaccination, such as the presence of memory cells or adaptive immune activity?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see an inner surface lined by membranes such as the dura mater?", "Does the image show the bony roof of the intracranial space?", "Is there a bony area adjacent to the cranial base or covered by the scalp?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that provides a rigid barrier to shield the upper portion of the brain from external trauma?", "Can you identify a bony framework that supports the cranial vault and maintains its structural integrity?", "Can you see a protective layer overlying the meninges, reducing the risk of injury or infection to these membranes?"]}}, "jejunum": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system and located in the abdomen?", "Can you identify a segment that is positioned between the duodenum and the ileum?", "Is there a structure that connects proximally to the duodenum and distally to the ileum?", "Does the image contain loops that could represent jejunal segments?", "Can you see a region that receives blood supply from branches of the superior mesenteric artery?", "Is there evidence of associated lymphatic structures such as mesenteric lymph nodes or lacteals?", "Does the image show a continuous transition from the duodenum at the duodenojejunal flexure?", "Can you identify an area where the transition into the ileum occurs without a distinct anatomical boundary?", "Is there a structure whose wall appears to have multiple layers, such as mucosa, submucosa, muscularis externa, and serosa?", "Does the image include a segment supported by a double layer of peritoneum anchoring it to the posterior abdominal wall?", "Can you see a region that might be innervated by fibers from the superior mesenteric plexus?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for absorbing nutrients during digestion?", "Can you identify a region with highly folded mucosa and numerous villi that increase surface area?", "Is there a part that receives partially digested food from an upstream segment and continues enzymatic breakdown?", "Does the image contain an area providing an optimal environment for pancreatic and brush border enzymes to act on food?", "Can you see a structure involved in absorbing carbohydrates as monosaccharides, proteins as amino acids, and fats as fatty acids?", "Is there a region contributing to water and electrolyte absorption for fluid balance?", "Does the image show a site where digestive enzymes interact with the lining to complete nutrient digestion?", "Can you identify an area where absorbed nutrients are transported into the bloodstream via capillaries?", "Is there evidence of coordinated smooth muscle contractions, such as peristalsis or segmentation, maintaining gut motility?", "Does the image reveal lymphoid tissue or immune cells, such as those found in the lamina propria or Peyer's patches, contributing to gut immune defense?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a lesion that is encapsulated or surrounded by a fibrous capsule?", "Is there a mass composed of cell types such as epithelial cells, fibroblasts, adipocytes, or Schwann cells?", "Is there a localized growth present in regions like the head and neck, extremities, abdomen, or pelvis?"], "contexual_behavior": [], "functions": ["Can you identify a mass that compresses or displaces surrounding anatomical structures without directly invading them?", "Is there a mass that might be compressing local blood vessels, potentially reducing blood flow to nearby tissues?", "Can you identify a mass that induces symptoms related to pressure on adjacent anatomical structures?"]}}, "neutrophils": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show any round cells with a nucleus divided into multiple connected lobes?", "Can you identify cells that are approximately 10 to 12 micrometers in diameter?", "Are there cells present that contain granules within their cytoplasm?", "Is there evidence of cells with a pale pink cytoplasm and a dark purple-blue nucleus when stained?", "Can you see any cells whose nucleus appears to have 2 to 5 lobes?", "Are there structures that could represent about 50% to 70% of the white blood cells in the sample?", "Does the image include cells that might contain enzymes such as myeloperoxidase or elastase?", "Can you find cells with granules rich in proteins like lactoferrin or defensins?", "Are there cells whose average size or volume could be estimated at around 300 to 400 femtoliters?", "Is it possible to observe cells with a density close to 1.08 grams per milliliter?", "Can you identify cells that typically have a lifespan of only a few hours in the bloodstream?", "Are there cells present that could account for a normal count of 1,500 to 8,000 per microliter in human blood?", "Does the image show cells that might have an intracellular pH in the range of 7.0 to 7.4?", "Can you see any cells whose cytoplasm contains both granules and glycogen?"], "relational": ["Does the image show a component of the immune system?", "Can you identify cells present in blood or connective tissue?", "Is there evidence of cells located within inflamed or infected tissue?", "Does the image include structures produced in the bone marrow?", "Are there cells that might be found alongside monocytes, eosinophils, or basophils?", "Can you see elements that interact with lymphocytes or other leukocytes?", "Is there a structure associated with blood components such as plasma, red blood cells, or platelets?", "Does the image show cells that could be transported by blood vessels or lymphatic vessels?", "Are there cells migrating toward damaged or infected tissue in the image?", "Can you identify a subtype of white blood cell in the image?", "Is there evidence of cells present in body fluids like pus, synovial fluid, or cerebrospinal fluid?"], "contexual_behavior": [], "functions": ["Does the image show cells involved in engulfing and destroying invading microorganisms?", "Can you identify cells that mediate inflammation by migrating to affected tissues?", "Is there evidence of cells releasing inflammatory mediators such as cytokines or chemokines?", "Does the image contain cells that perform phagocytosis and lysosomal degradation of pathogens or debris?", "Are there cells present that contribute to wound healing by clearing microbes and dead cells?", "Can you see cells that might be releasing growth factors to promote tissue repair?", "Is there evidence of degranulation, such as the release of antimicrobial peptides or proteases?", "Do you observe cells that could be producing reactive oxygen species for microbial killing?", "Are there cells that respond to chemotactic signals and adhere to the endothelium at sites of infection?", "Can you identify cells that interact with other immune cells by modulating immune responses?", "Is there evidence of rapid accumulation of cells at a site of bacterial infection?", "Do you see cells forming extracellular traps composed of chromatin and granular proteins?", "Are there cells present that participate in early defense and rapid recruitment during acute inflammation?", "Can you observe any signs of tissue damage that could be caused by the release of proteolytic enzymes or reactive oxygen species?", "Is there evidence of cells clearing tissue fragments and dead cells as part of tissue cleanup?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of a moist environment maintained by mucosal secretions?", "Is there a region where the thickness of the epithelial lining could be about 200 to 300 micrometers?", "Does the image show a tissue likely to have high glycogen content in its epithelium?"], "relational": ["Is there a region whose upper boundary is formed by the cervix and which continues into the uterus?", "Can you see a structure composed of stratified squamous epithelium, smooth muscle, and connective tissue?", "Can you identify a region that is anatomically connected to the cervix at its upper end and the vulva at its lower end?"], "contexual_behavior": ["Does the image show increased susceptibility to irritation that might follow disruption of the mucosal barrier, such as after douching?", "Can you see signs of weakened barrier function that might result from disruption of the normal microbial flora, such as after antibiotic use?", "Can you observe any indication of decreased elasticity that could result from tissue remodeling after childbirth?"], "functions": ["Is there a structure that facilitates the deposition of sperm during sexual intercourse?", "Does the image show a region that might maintain an acidic environment due to lactic acid production?", "Can you identify a passageway that enables the exit of menstrual blood from the uterus?"]}}, "amyloid": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show abnormal deposits in tissues such as the kidney, heart, or liver?", "Can you identify accumulations in regions associated with the renal, cardiovascular, or nervous systems?", "Is there evidence of extracellular material interacting with blood vessels or basement membranes?", "Does the image display structural features like fibrils, plaques, or nodules within any tissue?", "Can you see aggregates near glomeruli or nerve fibers?", "Is there a visible relationship between abnormal deposits and extracellular matrix components such as collagen or proteoglycans?", "Are there signs of protein accumulation in organs commonly affected, such as the spleen or brain?", "Does the image suggest the involvement of cells like plasma cells, neurons, or cardiomyocytes in the formation of abnormal material?", "Can you observe features that resemble prion-like or tau fibril aggregates?", "Is there evidence of material that could be present in body fluids like blood or cerebrospinal fluid?"], "contexual_behavior": [], "functions": ["Does the image show evidence of pathological protein aggregates that lack a normal physiological function?", "Can you identify structures that might indicate disruption of normal protein folding or cellular homeostasis?", "Is there a visible feature consistent with insoluble plaque formation associated with neurodegenerative diseases such as Alzheimer's?", "Does the image contain signs of synaptic dysfunction or neuronal loss that could be linked to abnormal protein deposits?", "Can you see extracellular accumulations that might represent beta-sheet-rich fibrils formed by protein aggregation?", "Is there evidence of altered tissue structure or rigidity due to extracellular deposition?", "Does the image suggest functional impairment of tissue that could be caused by abnormal protein deposits?", "Can you identify features that might indicate activation of microglia or the presence of neuroinflammation?", "Is there visual evidence of increased cell toxicity, such as signs of oxidative stress, membrane disruption, or apoptosis?", "Does the image show tissue changes that could be attributed to protein misfolding, aggregation, or cellular stress responses?", "Is there evidence of disrupted tissue architecture or organ dysfunction, particularly in the brain, heart, or kidneys, that could be linked to abnormal protein deposits?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there a structure that could be either soft or firm in consistency?", "On ultrasound, is there a region that appears hypoechoic, isoechoic, or hyperechoic compared to adjacent tissue?", "Can you find a structure with well-defined or ill-defined margins?"], "relational": ["Is there a mass with arteries, veins, lymphatic vessels, or ducts passing near or connected to it?", "Does the image show a structure situated in regions like the neck, lungs, breast, or subcutaneous tissue?", "Can you identify a structural component that may belong to the endocrine, respiratory, or integumentary system?"], "contexual_behavior": ["Does the image show a site with enhanced local immune response, such as lymphocytic infiltration and cytokine production in autoimmune disease?", "Can you identify a region that might impair organ function by causing local edema, cellular infiltration, or compressing nearby structures?", "Does the image reveal an area with decreased metabolic activity, which might indicate a response to therapy or reduced cellular viability?"], "functions": ["Does the image show a formation that could signal tissue injury or a repair response to chronic damage?", "Does the image contain a site that could contribute to disease progression, such as persistent inflammation, tumor development, or organ dysfunction?", "Does the image show a localized mass that could indicate abnormal tissue growth or a response to injury?"]}}, "atherosclerosis": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show any abnormalities within the cardiovascular system?", "Can you identify changes affecting arteries, such as the coronary or carotid arteries?", "Is there evidence of pathology involving the vascular endothelium or smooth muscle tissue?", "Does the image display alterations in the arterial wall, particularly in the intima or media layers?", "Are there visible plaques or lesions containing cells like macrophages or foam cells?", "Can you see any interaction between blood cells or platelets and the arterial wall?", "Is there a structure that appears to affect large or medium-sized arteries, such as the aorta or peripheral arteries?", "Does the image suggest involvement of connective tissue within a blood vessel?", "Are there signs of disease that could impact organs like the heart, brain, or kidneys through vascular changes?", "Can you observe any changes in the extracellular matrix associated with a blood vessel lesion?"], "contexual_behavior": [], "functions": ["Does the image show evidence of arterial wall thickening or plaque buildup?", "Can you identify regions where the arterial lumen appears narrowed, potentially restricting blood flow?", "Is there a visible structure that could be associated with chronic inflammation within a blood vessel?", "Does the image suggest reduced oxygen delivery to tissues, such as signs of ischemia or hypoperfusion?", "Can you see blood vessels that appear less elastic or show impaired ability to dilate?", "Is there any indication of vascular changes that could increase the risk of heart attack or stroke, such as plaque rupture or thrombosis?", "Are there visual cues of inflammatory cell infiltration, such as macrophages or foam cell accumulation within the vessel wall?", "Does the vessel wall display features like intimal thickening, calcification, or loss of structural integrity?", "Can you identify areas with lipid accumulation, smooth muscle proliferation, or extracellular matrix deposition in the vessel wall?", "Is there evidence of endothelial dysfunction, such as reduced nitric oxide production or increased permeability in the vascular lining?", "Do the arteries in the image appear stiffened or show signs of increased resistance, possibly affecting blood pressure regulation?", "Are there features suggestive of collagen deposition or calcification contributing to vascular stiffness?", "Can you see surfaces within the vessel that might promote platelet aggregation or thrombosis formation?", "Is there any indication of reduced perfusion or impaired blood supply to downstream tissues or organs?", "Do you observe signs that could indicate chronic ischemia or compromised organ function due to impaired arterial blood flow?"]}, "no_questions": {"contexual_properties": ["Is there evidence of abnormal surface texture on the projections, which could result from epithelial damage or excessive mucus production?", "Are there areas where the normal architecture of the projections is lost, potentially due to severe infection, autoimmune disorder, or toxic injury?", "Do any of the structures appear blunted, which could be associated with autoimmune enteropathies or chronic inflammation?"], "properties": ["Is there evidence of a high density of projections, about 10 to 40 per square millimeter?", "Is the local pH at the surface of these projections likely to be between 6.5 and 7.5?", "Do the projections contain a central capillary network or a lacteal?"], "relational": ["Can you identify projections containing both blood vessels and lymphatic channels?", "Can you identify projections that are found within the small intestine?", "Are there cells present that resemble enterocytes, goblet cells, or Paneth cells?"], "contexual_behavior": ["Is there a structure that shows signs of impaired function or epithelial damage, which could result from chronic infection and persistent inflammation?", "Is there evidence of increased activity or structural adaptation to meet elevated nutritional demands during periods of rapid growth?", "Is there evidence of impaired fat absorption, such as structural abnormalities or dysfunctional enterocytes, which might be seen in malabsorption syndromes?"], "functions": ["Does the image display features that enable the transfer of digested molecules into the body?", "Does the image show finger-like projections that increase the surface area of the intestinal lining?", "Are there visible projections that provide greater contact with chyme in the intestine?"]}}, "brain": {"yes_questions": {"contexual_properties": ["Does the image show a structure that appears swollen, which could indicate conditions like cerebral edema or infection?", "Is there evidence of shrinkage or reduced size in a structure that might be associated with aging or neurodegenerative diseases?", "Can you identify an area with decreased volume that could be related to disorders such as Alzheimer's disease or malnutrition?", "Does the image reveal abnormal lesions that might suggest multiple sclerosis, stroke, or a tumor?", "Is there visible accumulation of fluid within a structure, as seen in hydrocephalus or meningitis?", "Can you detect regions with increased iron deposition, which may occur in neurodegenerative diseases like Parkinson's disease?", "Is there a change in color, such as pallor or discoloration, that could result from hypoxia or hemorrhage?", "Does the structure appear softer than normal, possibly due to liquefactive necrosis or severe hypoxic injury?", "Is there evidence of increased firmness, which might be caused by chronic gliosis or calcification?", "Can you see plaques or deposits that are characteristic of Alzheimer's disease or demyelinating disorders?", "Are there increased white matter lesions visible, which could be associated with aging or small vessel disease?", "Does the image suggest atrophy, as seen in chronic neurodegenerative diseases or after prolonged injury?", "Is there any indication of increased intracranial pressure, such as compression or displacement of adjacent structures?", "Can you identify hemorrhages that might be due to hypertension, trauma, or coagulopathies?", "Is there evidence of abnormal electrical activity, which could be related to epilepsy or encephalopathy?", "Can you detect amyloid accumulation, as seen in Alzheimer's disease or cerebral amyloid angiopathy?", "Does the structure display abnormal tissue density, which may be present in stroke, tumors, or demyelinating diseases?", "Is there a region with altered metabolic activity, either increased or decreased, that could suggest epilepsy, tumors, or neurodegenerative diseases?", "Can you see calcifications that might be due to congenital infections, metabolic disorders, or chronic infarcts?", "Is there evidence of changes in neurotransmitter-related features, which could be associated with psychiatric disorders or Parkinson's disease?"], "properties": ["Is there a structure in the image that has an irregular, convoluted surface with visible gyri and sulci?", "Can you identify an object that appears pale grayish-pink in color?", "Does the image show a structure whose size could be approximately 15 centimeters in length and 14 centimeters in width?", "Is there an object present that could have a volume between 1,200 and 1,500 milliliters?", "Can you see a structure that is likely to contain cell types such as neurons, astrocytes, or oligodendrocytes?", "Is there evidence of a region that could contain around 86 billion neurons?", "Does the image include a structure where the number of glial cells might be roughly equal to or slightly greater than the number of neurons?", "Can you identify an object that might have a gray matter to white matter ratio of about 1.3 to 1?", "Is there a structure that could have a water content of approximately 75% to 80% by weight?", "Does the image show an object that might have a lipid content of about 10% to 12% of its wet weight?", "Is there a region that could contain myelin making up about 20% of its dry weight?", "Can you see a structure that might have a cholesterol content of 15 to 20 milligrams per gram of tissue?", "Is there an object that could have an iron concentration ranging from 30 to 60 micrograms per gram, depending on the region?", "Does the image include a structure that typically maintains a temperature between 36.5 and 38 degrees Celsius?", "Can you identify an object that would normally have a pH between 7.1 and 7.4?", "Is there a region that could consume oxygen at a rate of about 3.5 milliliters per 100 grams per minute?", "Does the image show a structure where the glucose concentration might be between 0.7 and 2.5 millimoles per liter?", "Can you see an object that would likely have a protein content of approximately 8% to 10% of its wet weight?", "Is there a structure present that could weigh between 1,300 and 1,400 grams in an adult human?"], "relational": ["Does the image show a structure that is part of the nervous system?", "Can you identify regions such as the cerebrum, cerebellum, or brainstem in the image?", "Is there a structure that connects directly to the spinal cord via the brainstem or medulla oblongata?", "Are protective membranes like the dura mater, arachnoid mater, or pia mater visible surrounding any structure?", "Does the image include blood vessels such as the internal carotid arteries or vertebral arteries supplying a central organ?", "Can you see internal cavities resembling ventricles, such as the lateral, third, or fourth ventricle?", "Is there evidence of cranial nerves, such as the optic nerve or other nerves originating from a central structure?", "Does the image show a structure protected by the bones of the cranium or skull?", "Are there areas distinguishable as gray matter or white matter within a central organ?", "Can you identify neural tissue or glial cells within any structure present?", "Is there a principal organ of the central nervous system coordinating with the spinal cord visible in the image?"], "contexual_behavior": ["Does the image show a structure that reduces its processing speed during normal aging or neurodegenerative conditions?", "Can you identify an area that would increase neural activity in response to stress via the hypothalamic-pituitary-adrenal axis?", "Is there a structure whose memory formation could be impaired by sleep deprivation affecting REM and slow-wave sleep?", "Does the image contain a region where neurotransmitter release, such as serotonin, norepinephrine, or dopamine, might be decreased in depression?", "Can you see an area that enhances synaptic plasticity during learning through mechanisms like long-term potentiation?", "Is there a structure that fails to regulate motor control in Parkinson\u2019s disease due to degeneration of dopaminergic neurons?", "Does the image show a region that would increase glucose uptake during intense mental activity?", "Can you identify a structure that reduces oxygen consumption during anesthesia as neural activity decreases?", "Is there an area that alters its function during hypoxia by shifting to anaerobic metabolism and reducing neuronal activity?", "Does the image contain a region that shows decreased responsiveness under sedation due to suppression of cortical and subcortical activity?", "Can you see a structure that increases pain perception in chronic pain conditions through central sensitization?", "Is there an area that fails to coordinate sensory input after injury when neural pathways are disrupted by trauma or stroke?", "Does the image show a region that enhances neuroprotection during mild hypothermia by reducing metabolic demand?", "Can you identify a structure that reduces executive function during aging as prefrontal cortex efficiency declines?", "Is there an area that increases neuroinflammation in neurodegenerative diseases due to activation of microglia and astrocytes?", "Does the image contain a region that alters its activity during meditation by modulating the default mode network and increasing alpha wave activity?", "Can you see a structure that shows impaired signal transmission in multiple sclerosis due to demyelination of central nervous system axons?", "Is there a region that increases blood flow during physical exercise to supply active neurons with oxygen and nutrients?", "Does the image show a structure that reduces its ability to regulate emotions in anxiety disorders due to dysregulation of limbic and prefrontal circuits?", "Can you identify an area that fails to maintain homeostasis during severe trauma when autoregulatory mechanisms are overwhelmed?"], "functions": ["Does the image contain a structure responsible for cognition and perception?", "Is there an object that controls movement by sending signals to muscles?", "Can you identify a region involved in processing sensory information?", "Does the image show structures such as the amygdala or limbic system that regulate emotions?", "Is there a visible area associated with memory formation, such as the hippocampus?", "Can you see regions like the basal ganglia or cerebellum that coordinate voluntary actions?", "Does the image include a structure that regulates hormone release through the pituitary gland?", "Is there an area related to language comprehension or production, such as Broca\u2019s or Wernicke\u2019s area?", "Can you identify a region that maintains homeostasis by adjusting bodily functions?", "Does the image show centers like the medulla oblongata or brainstem involved in regulating breathing and heart rate?", "Is there a structure supporting learning and cognition through neural plasticity?", "Can you see association areas that integrate information from multiple senses?", "Is there a region involved in regulating sleep and circadian rhythms?", "Does the image contain a structure that participates in the stress response by activating the HPA axis?", "Can you identify an area involved in decision making, such as the prefrontal cortex?"]}, "no_questions": {"contexual_properties": ["Does the image contain features consistent with bleeding related to placental separation?", "Can you identify signs of blood accumulation near the site where the placenta attaches?", "Is there visual evidence of disrupted placental attachment accompanied by hemorrhage?"], "properties": ["Does the image show a region where blood loss might be occurring at a rate exceeding 100 milliliters per minute?", "Does the image suggest the presence of blood with reduced viscosity compared to normal?", "Is there a feature suggesting a hematocrit level reduced to less than 30 percent?"], "relational": ["Is there visual evidence of the placenta being partially or completely detached from the uterine wall?", "Does the image reveal abnormalities in the retroplacental area or intervillous space?", "Does the image show evidence of a disruption at the interface between the placenta and the uterine wall?"], "contexual_behavior": ["Is there a visible area suggesting disrupted attachment between the placenta and the uterine wall accompanied by hemorrhage?", "Can you identify signs of bleeding in association with placental tissue?", "Does the image display features consistent with blood loss adjacent to the placenta?"], "functions": ["Can you identify disruption of placental integrity that might reduce oxygen and nutrient transfer to the fetus?", "Can you identify reduced fetal blood flow that might result in fetal anemia or compromised fetal circulation?", "Does the image show signs consistent with hypovolemic shock, such as rapid depletion of maternal blood volume or impaired tissue perfusion?"]}}, "blood": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a component of the circulatory system?", "Can you identify structures where erythrocytes or leukocytes might be present?", "Is there evidence of platelets within any visible structures?", "Does the image include vessels such as arteries, veins, or capillaries?", "Can you see organs that are known to produce cellular components found in a fluid, such as the bone marrow, liver, or spleen?", "Is there a visible process or structure related to hematopoiesis?", "Are there tissues present that interact with a fluid during gas exchange, such as alveoli in the lungs?", "Does the image contain organs that receive a supply of a circulating fluid, such as the brain, kidneys, or muscles?", "Can you identify a structure that transports fluid between the heart and lungs, such as pulmonary arteries or pulmonary veins?", "Is there a visible component that could be plasma, containing water, proteins, and solutes?", "Are there features suggesting the involvement of the nervous, endocrine, or immune systems that depend on a circulating fluid?"], "contexual_behavior": [], "functions": ["Does the image show a substance responsible for transporting gases, nutrients, hormones, and waste products throughout the body?", "Can you identify a component that carries oxygen to tissues by means of hemoglobin within red blood cells?", "Is there evidence of a fluid that removes carbon dioxide from tissues, either as bicarbonate in plasma or bound to hemoglobin?", "Does the image contain a medium that transports nutrients absorbed from the digestive tract to cells?", "Can you see a fluid that carries endocrine hormones from glands to their target organs?", "Is there a component that supports the immune system by circulating white blood cells and antibodies?", "Does the image show a substance involved in fighting infections by delivering immune cells and proteins to affected areas?", "Can you identify a fluid that helps regulate body temperature through redistribution of heat via blood vessels?", "Is there evidence of a process where platelets and coagulation factors form a fibrin clot at a wound site?", "Does the image contain a medium that maintains pH balance by buffering acids and bases?", "Can you see a substance that removes metabolic byproducts such as urea and creatinine for excretion by the kidneys?", "Is there a component that delivers heat from the body's core to peripheral tissues?", "Does the image show a liquid matrix that carries cells, nutrients, hormones, and waste products?", "Can you identify a fluid that distributes minerals and salts by dissolving electrolytes and delivering them to tissues?", "Is there evidence of a role in inflammation, such as the transport of immune mediators and cells to sites of tissue injury or infection?"]}, "no_questions": {"contexual_properties": ["Can you see a substance that seems difficult to remove, perhaps due to hardening or increased adhesion?", "Can you identify a layer that is less transparent, possibly from thickening, pigment accumulation, or cellular infiltration?", "Can you identify a layer that looks denser, possibly from compact substance deposition or dehydration?"], "properties": ["Is there a cell that appears to be attached to a substrate with significant adhesion strength?", "Is there a cell present that might have a cytoplasmic pH close to 7.2?", "Does the image show a cell with a flattened or spread-out appearance on a surface?"], "relational": ["Can you see tissue that appears to fix organs in place abnormally?", "Does the image contain fibrous structures in regions such as the abdominal, pelvic, or thoracic cavity?", "Are there visible connections between the intestines and the abdominal wall or omentum?"], "contexual_behavior": ["Are there cells that appear to have lost adhesion and gained migratory properties, as would be expected during epithelial-mesenchymal transition?", "Can you identify restoration of normal cell attachment that might result from anti-inflammatory treatment?", "Does the image show cells at a wound site during the proliferative phase of tissue repair, where increased attachment and migration are expected?"], "functions": ["Does the image reveal the presence of integrins or other adhesion receptors mediating matrix interaction?", "Are there visible features suggesting cell migration or tissue repair, such as cells moving toward an injury site?", "Are there signs of cells guiding tissue development, such as organized positioning or differentiation patterns?"]}}}
[ { "answer": "lobular carcinomas", "extracted_concepts": [ "relatively subtle, irregular masses", "mammograms", "lobular carcinomas" ], "question": "what often appear as relatively subtle, irregular masses in mammograms?" }, { "answer": "relatively subtle", "extracted_concepts": [ "lobular carcinomas" ], "question": "what do lobular carcinomas offen appear as?" }, { "answer": "yes", "extracted_concepts": [ "mammograms", "irregular masses", "lobular carcinomas" ], "question": "do lobular carcinomas appear as relatively subtle, irregular masses in mammograms?" }, { "answer": "no", "extracted_concepts": [ "mammograms", "bowing of legs", "irregular masses" ], "question": "does bowing of legs appear as relatively subtle, irregular masses in mammograms?" } ]	["lobular carcinomas", "relatively subtle, irregular masses", "bowing of legs", "irregular masses", "mammograms"]	{"lobular carcinomas": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show an abnormality originating from the epithelial tissue of mammary lobules?", "Is there a lesion adjacent to breast stroma or adipose tissue?", "Can you identify a pathological structure associated with the mammary gland system?", "Is there evidence of a process affecting any region of the breast, such as the upper outer quadrant or central area?", "Does the image reveal changes involving lobular epithelial cells?", "Is there a mass structurally related to mammary lobules or terminal ducts?", "Can you see involvement of lymphatic structures like axillary or internal mammary lymph nodes?", "Is there a lesion with boundaries defined by breast lobule margins, surrounding stroma, or basement membrane?", "Does the abnormality reside within a larger structure such as the breast or mammary gland?", "Is there a pathological interaction with lactiferous ducts, Cooper\u2019s ligaments, or the nipple-areolar complex?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Can you see any lesions that may indicate the presence of tumors, cysts, or infectious processes?", "Can you identify fluid accumulation that could suggest petrous apicitis, cyst formation, or abscess development?", "Is there evidence of sclerosis in a structure that might result from chronic inflammation, osteopetrosis, or otosclerosis?"], "properties": ["Can you see a structure that contains cell types such as osteocytes, osteoblasts, and osteoclasts?", "Can you identify a structure with a Vickers hardness value of about 60 to 70 HV?", "Does the image include a bone with a water content of approximately 10 to 20 percent by weight?"], "relational": ["Does the image show attachments for membranes or ligaments such as the tentorium cerebelli or the petro-sphenoidal ligament?", "Can you see foramina like the internal acoustic meatus or carotid canal within the temporal bone?", "Is there a cavity or space resembling the bony labyrinth or internal acoustic meatus present?"], "contexual_behavior": ["Does the image show evidence of impaired protection of inner ear structures, such as might be seen in the presence of a temporal bone fracture or osteolytic lesion?", "Does the image show age-related changes like bone sclerosis or degeneration that could contribute to a decline in hearing transmission?", "Can you identify any compromise of the facial nerve's structural support, possibly due to tumors such as schwannomas or cholesteatomas?"], "functions": ["Is there a dense bony structure in the image that provides protection and structural support to delicate inner ear components?", "Can you identify a barrier that separates the middle ear from the inner ear, helping to prevent the spread of infection and maintain compartmentalization?", "Is there a structure acting as a buffer between the inner ear and the posterior cranial fossa, contributing to brainstem protection at the cranial base?"]}}, "bowing of legs": {"yes_questions": {"contexual_properties": ["Does the image show a lower limb alignment that is more pronounced during periods of rapid growth or in the presence of bone disorders such as rickets or Blount disease?", "Can you identify a change in leg alignment that typically decreases as children grow older and their bones mature?", "Is there evidence of a transition in the direction of leg curvature, suggesting a developmental stage from genu varum to genu valgum?", "Does the image reveal swelling around the knee or leg that could indicate underlying inflammation, infection, or trauma?", "Are there visual signs of decreased bone density or bone demineralization in the lower limbs, suggestive of metabolic bone diseases?", "Can you observe joint enlargement near the knees, which might be associated with chronic inflammation or arthropathy?", "Is there a visible deformity of the legs that appears to worsen with growth, possibly indicating a progressive disorder such as Blount disease or untreated rickets?", "Does the image suggest improvement in leg alignment that could be attributed to medical therapy or orthopedic intervention?", "Is there asymmetry in the curvature of the legs, with one limb appearing more affected than the other, as seen in unilateral deformity?", "Can you detect signs of tenderness or pain on palpation, such as protective posturing or facial expressions, that might be associated with infection, inflammation, or fracture?", "Are there abnormal curvatures of the legs visible on imaging studies, such as X-rays, indicating an angular deformity?", "Does the image show changes in gait, such as waddling or limping, that could result from altered joint mechanics?", "Can you identify alterations in bone composition, such as decreased mineralization, in the lower limbs that may be due to osteomalacia or rickets?", "Is the curvature of the legs more apparent during weight-bearing activities like standing or walking?", "Does the image suggest that the leg alignment abnormality is less noticeable in an older child, consistent with spontaneous correction during normal development?"], "properties": ["Does the image show lower limbs with a curvature where the angle between the thigh and shin bones appears to be greater than 10 degrees?", "Can you identify a case where the curvature of the legs could be classified as mild, moderate, or severe based on the angle between the femoral and tibial axes?", "Is there a visible maximum curvature located at the upper part of the shin bone near the knee?", "Does the distance between the inner sides of the knees appear to be greater than 6 centimeters when the ankles are together?", "Is there evidence suggesting the individual is in the early walking age range, typically between 1 and 3 years old?", "Do both legs show a similar and symmetric pattern of curvature, or is there noticeable asymmetry?", "Can you assess whether the length of the thigh or shin bones appears normal, or is there visible shortening?", "Does the bone density in the image appear reduced, as might be seen in conditions like rickets, or does it look normal?", "Is there a visible inward (medial) concavity of the shin bone, resulting in a bowing that causes the knees to be farther apart than the ankles?", "Does the thigh bone appear straight, or is there a mild curvature present?", "Is there a visible widening of the growth plate near the ends of the long bones, which could suggest a metabolic bone disorder?", "Can you observe thinning or irregularity of the outer layer (cortex) of the long bones, especially near the curved regions?", "Are there radiographic features such as medial bowing of the shin bone, widened growth plates, or changes near the metaphysis visible in the image?", "Does the alignment of the weight-bearing axis of the legs appear to pass medial to the center of the knee joint, indicating a mechanical axis shift?"], "relational": ["Does the image show any abnormal curvature in the long bones of the lower limb?", "Can you identify a deviation in the alignment of the femur, tibia, or fibula?", "Is there evidence of altered load distribution or mechanical axis at the knee joint?", "Do the thigh, leg, or knee regions appear to have a medial or lateral deviation?", "Are there visible changes in the alignment of the knee, ankle, or hip joints?", "Can you see any differences in the growth plates of the lower limb bones?", "Is there an observable alteration in the relationship between bones and connective tissues such as ligaments or tendons in the lower limb?", "Do the quadriceps, hamstrings, or gastrocnemius muscles appear affected by changes in bone alignment?", "Is there a noticeable change in the skeletal or muscular system of the lower limbs?", "Are the supporting structures like cartilage, ligaments, or muscles showing signs of compensating for abnormal leg alignment?"], "contexual_behavior": ["Does the image show an individual with lower limb alignment that could disrupt normal walking function?", "Can you identify signs of gait disturbance or altered walking patterns in the image?", "Is there evidence of lower limb malalignment that might affect weight-bearing efficiency?", "Does the image suggest deviation of the mechanical axis of the legs, potentially increasing stress on certain joint regions?", "Can you observe uneven force distribution across the knee or ankle joints during physical activity?", "Is there a visible abnormal curvature of the legs that could reduce shock absorption while running?", "Does the image depict an individual who may have compromised postural stability or balance, especially if elderly?", "Are there visual cues suggesting impaired bone mineralization or softening of long bones, possibly due to vitamin D deficiency?", "Can you see signs of musculoskeletal fatigue or discomfort that might impair the ability to stand for long periods?", "Is there evidence of increased risk of falls or gait instability during movement?", "Does the image show compensatory changes in walking pattern that might indicate adaptation to discomfort or instability?", "Are there indications of reduced mobility or limited physical activity in a child, possibly associated with rickets?", "Can you observe abnormal lower limb alignment that might impair performance or agility during sports activities?", "Is there evidence that excessive body weight or obesity could be amplifying mechanical stress on deformed bones?", "Does the image suggest altered force distribution or increased pressure on the medial or lateral compartments of the knee joint?", "Are there visual signs of improvement in lower limb alignment that could be attributed to correction of an underlying metabolic disorder?"], "functions": ["Does the image show an individual with signs of limited mobility or difficulty walking or running?", "Can you observe an abnormal gait pattern, such as limping or waddling, that might indicate altered weight distribution?", "Is there visible evidence of joint misalignment in the lower limbs that could suggest an increased risk of dysfunction or early degenerative changes?", "Does the posture or stance in the image suggest compensatory mechanisms, such as increased trunk sway or unusual foot positioning?", "Can you identify features that indicate compromised balance or reduced stability, such as an unsteady stance or a tendency to fall?", "Is there any indication of discomfort or pain in the knees, hips, or lower back, such as protective gestures or facial expressions?", "Does the alignment of the lower limbs suggest uneven distribution of mechanical stress or focal overload in the bones or joints?", "Can you see signs of impaired function in the knees or ankles, such as abnormal joint loading or altered movement patterns?", "Is there evidence that the individual may have reduced participation in physical activity or impaired exercise performance due to instability or inefficient movement?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show changes involving the epidermis, dermis, submucosa, or parenchyma?", "Can you identify an area with well-defined borders, uniform cell composition, or predictable growth patterns compared to other abnormal regions?", "Does the image show an area within epithelial, connective, or muscle tissue that appears different from the surrounding tissue?"], "contexual_behavior": ["Is there a structure in the image that appears to heal more slowly, possibly suggesting impaired immune function?", "Is there a lesion that has increased in size, possibly as a result of chronic irritation from repeated mechanical, chemical, or physical insults?", "Can you see a lesion that appears more susceptible to secondary infection, potentially indicating compromised immunity?"], "functions": ["Does the image display signs of inflammation, like the presence of inflammatory cells or cytokine activity?", "Can you identify an area where tissue regeneration might be hindered, such as by scar formation or a hostile microenvironment?", "Can you identify a location where normal tissue architecture seems impaired or signaling appears abnormal?"]}}, "mammograms": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image appear to have dimensions similar to standard medical imaging sizes, such as 18 x 24 cm or 24 x 30 cm?", "Can you determine if the image resolution is fine enough to distinguish features at approximately 50 microns per pixel?", "Is there evidence that the grayscale depth in the image allows for 12 to 16 bits per pixel?", "Does the image suggest that it was acquired using a process delivering a radiation dose of about 1 to 2 milligray per view?", "Can you infer if the pixel spacing in the image is within the range of 0.05 mm to 0.1 mm?", "Does the image show contrast levels optimized for differentiating soft tissue structures?", "Is there any indication that the image format follows the DICOM standard?", "Can you identify regions in the image that could be categorized as fatty, scattered, heterogeneously dense, or extremely dense tissue?", "Does the image suggest that a compression force between 10 and 20 kilograms was applied during acquisition?", "Is the field of view broad enough to include the entire breast, pectoral muscle, and axillary tail?", "Can you infer if the image acquisition duration was approximately 1 to 2 seconds per exposure?", "Does the image show tissue thickness in the range of 2 cm to 6 cm?", "Is the noise level in the image low, consistent with high signal-to-noise ratio requirements?", "Does the image display a dynamic range that could represent 4096 to 65536 gray levels?", "Is the background brightness in the image adjusted to enhance lesion visibility and reduce glare?"], "relational": ["Does the image show anatomical features such as ducts or lobules within a specific region of the body?", "Can you identify glandular, adipose, or fibrous connective tissue in the visualized area?", "Is there a visible anatomical landmark such as a nipple, skin line, or inframammary fold?", "Does the image include regions like the upper outer quadrant or retroareolar area?", "Can you see the relationship between breast tissue and lymphatic structures such as axillary or intramammary lymph nodes?", "Is there evidence of anatomical variations such as differences in density, size, shape, or the presence of implants?", "Are structures adjacent to the breast, like the pectoralis major muscle, ribs, or axilla, visible in the image?", "Can you distinguish between dense glandular tissue and fatty tissue in the visualized area?", "Does the image appear to be acquired in a specific anatomical plane, such as cranio-caudal or medio-lateral oblique?"], "contexual_behavior": ["Does the image suggest the presence of dense tissue that could reduce the sensitivity of tumor detection, particularly in younger individuals?", "Can you identify features that might indicate high breast density, which is associated with lower diagnostic accuracy in certain age groups?", "Is there evidence of hormonal influences, such as those seen during the menstrual cycle or pregnancy, that could increase the likelihood of false-positive findings?", "Does the tissue composition appear more fatty, as might be expected after menopause, potentially improving the sensitivity of the imaging?", "Are there visual signs of breast implants that could obscure tissue and limit the identification of early-stage abnormalities?", "Can you detect patterns that might be consistent with inflammatory conditions, which could reduce the specificity of the findings?", "Is there an increased presence of glandular tissue or density that could be associated with hormone replacement therapy and a higher rate of detected abnormalities?", "Do you observe any evidence of prior surgical intervention, such as scar tissue or altered anatomy, that might decrease the effectiveness of the imaging?", "Are there overlapping structures or cystic patterns that could indicate cystic breast disease and reduce the reliability of the interpretation?", "Does the image suggest increased glandular tissue, as might occur during pregnancy or lactation, potentially altering the diagnostic role of the imaging?", "Is there evidence of tissue fibrosis or architectural distortion that could be related to prior radiation therapy and lead to inconclusive results?", "Can you identify features that might benefit from digital imaging technology, especially in individuals under 50 or those with dense tissue?", "Does the image suggest rapid changes in tissue that could make monitoring treatment response in aggressive conditions more challenging?", "Are there visual cues of reduced adipose tissue, such as after weight loss, which could enhance image clarity and increase detection rates?", "Do you notice any technical artifacts, such as motion blur or improper positioning, that could decrease the interpretive accuracy of the imaging?"], "functions": ["Does the image provide information that could be used for the detection or assessment of breast cancer?", "Can you identify any suspicious lesions or abnormalities that might be visualized before clinical symptoms appear?", "Is there evidence in the image that could be used to monitor changes in breast tissue over time?", "Does the image appear suitable for use in a population-based screening program aimed at early detection of disease?", "Can you see features that might guide further diagnostic procedures such as biopsies or additional imaging studies?", "Is there visual information that could help evaluate the response to breast cancer treatment by documenting changes in tumor size or characteristics?", "Are there lesions present whose radiographic features, such as shape, margins, or density, could help differentiate between benign and malignant findings?", "Does the image reveal patterns or findings, such as dense tissue, that could contribute to breast cancer risk assessment?", "Can you identify microcalcifications that may serve as early indicators of ductal carcinoma in situ or other pathologies?", "Is there detailed anatomical information present that could aid in planning surgical or therapeutic interventions by localizing lesions and assessing their size or extent?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there evidence of a process originating from lymphoid progenitor cells within the lymphatic system?", "Can you observe alterations in blood components like white blood cells, red blood cells, or platelets?", "Is there infiltration of tissues like bone marrow, lymph nodes, spleen, or the central nervous system visible?"], "contexual_behavior": [], "functions": ["Can you identify signs of reduced red blood cell production, such as features suggestive of anemia?", "Are there features indicating multi-organ impact, such as signs of hypoxia, hemorrhage, or infection, that could result from bone marrow failure?", "Does the image suggest overcrowding of the bone marrow by malignant cells, leading to suppression of healthy blood cell development?"]}}}
[ { "answer": "yes", "extracted_concepts": [ "spleen" ], "question": "does this image show spleen, normal?" }, { "answer": "no", "extracted_concepts": [ "spleen", "normal", "abdomen" ], "question": "does abdomen show spleen, normal?" }, { "answer": "hematologic", "extracted_concepts": [], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "hematologic" ], "question": "is hematologic present?" }, { "answer": "spleen", "extracted_concepts": [ "spleen" ], "question": "where is this part in?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" } ]	["hematologic", "spleen", "normal", "abdomen"]	{"hematologic": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image contain a sample composed of red blood cells, white blood cells, platelets, and plasma?", "Can you identify a specimen that typically appears red in color?", "Is there evidence of a fluid with a viscosity between 3 and 4 centipoise at 37\u00b0C?", "Does the image show a sample whose pH would be expected to fall between 7.35 and 7.45?", "Can you see a sample that might have a density around 1.050 to 1.060 g/mL?", "Is there a specimen that would normally be collected in a volume between 2 and 10 mL for analysis?", "Does the image include a sample that could be assessed for hemoglobin concentration in the range of 12.0\u201317.5 g/dL depending on sex?", "Can you identify a sample where the hematocrit value might be between 36% and 53%?", "Is there a structure that would be expected to have a red blood cell count within the typical range for males or females?", "Does the image show a specimen that could be evaluated for a white blood cell count between 4,000 and 11,000 cells/\u03bcL?", "Can you see a sample that would be expected to contain 150,000 to 450,000 platelets per microliter?", "Is there a sample present that could have a mean corpuscular volume (MCV) between 80 and 100 fL?", "Does the image include a specimen where the mean corpuscular hemoglobin concentration (MCHC) might be 32\u201336 g/dL?", "Can you identify a sample that could have a mean corpuscular hemoglobin (MCH) of 27\u201333 pg/cell?", "Is there a specimen that would be expected to have an iron level between 60 and 170 \u03bcg/dL?", "Does the image show a sample that could have a fasting glucose concentration of 70\u201399 mg/dL?", "Can you see a specimen with a protein content typically between 6 and 8 g/dL?", "Is there a sample that would be expected to have a sodium concentration of 135\u2013145 mmol/L?", "Does the image include a specimen where the potassium concentration might be 3.5\u20135.0 mmol/L?", "Can you identify a sample that could have a calcium concentration between 8.5 and 10.5 mg/dL?"], "relational": ["Does the image show any structures that are part of the circulatory or immune systems?", "Can you identify an organ such as the bone marrow, spleen, or thymus?", "Is there evidence of hematopoietic or lymphoid tissue present?", "Does the image contain cells like red blood cells, white blood cells, or platelets?", "Are there visible blood vessels, lymph nodes, or the heart in the image?", "Can you see anatomical features that participate in immunity, fluid balance, or cell production?", "Is there a body fluid such as blood, plasma, or serum depicted?", "Does the image include regions like the bone marrow, spleen, lymph nodes, or bloodstream?", "Are arteries, veins, or capillaries visible in the image?", "Can you identify organs that contribute to the formation of blood components, such as the bone marrow, liver, or spleen?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a process responsible for transporting oxygen in the body?", "Can you identify structures or cells involved in immune defense, such as those producing antibodies or performing phagocytosis?", "Is there visual indication of mechanisms that facilitate blood clotting, like platelet activation or fibrin formation?", "Does the image include features related to the production of blood cells, such as hematopoiesis occurring in bone marrow?", "Can you see evidence of waste removal from the blood, such as the transport of metabolic byproducts or carbon dioxide?", "Is there a visible indication of processes that help maintain pH balance, possibly through buffering by plasma proteins or hemoglobin?", "Does the image show a response to infection or injury, such as activation of leukocytes or the presence of inflammatory mediators?", "Can you identify features related to the regulation of bleeding, such as vasoconstriction or platelet plug formation?", "Is there evidence of nutrient transport in the bloodstream, such as the movement of glucose, amino acids, or lipids?", "Does the image display signs of inflammation, like the mobilization of leukocytes or acute phase proteins?", "Can you observe features that suggest maintenance of blood volume, such as regulation by plasma proteins or erythrocyte mass?", "Is there visual evidence of the removal of old or damaged blood cells, such as phagocytosis by macrophages in organs like the spleen or liver?"]}, "no_questions": {"contexual_properties": ["Is there swelling or edema present in a capsule, possibly indicating acute inflammation or infection?", "Is there a visible change in the composition of a capsule, such as fibrosis, calcification, or infiltration by abnormal cells?", "Does any capsule-like area appear disrupted or lacking integrity, which could be due to trauma, infarction, or severe infection?"], "properties": ["Is there an area where the protein content is predominantly structural, such as collagen?", "Is there a layer composed mainly of dense connective tissue rich in collagen fibers?", "Does the image show a layer with low cellularity, primarily containing fibroblasts?"], "relational": ["Can you identify an outer boundary that surrounds the adrenal gland?", "Is there a structure positioned near the kidney and diaphragm?", "Does the image contain a region composed primarily of dense connective tissue?"], "contexual_behavior": ["Does the image reveal compromised barrier function or loss of structural proteins that could be due to infection or the effect of inflammatory cytokines?", "Is there evidence of impaired structural support, such as fibrosis or degradation, that could result from immune cell infiltration in autoimmune disease?", "Can you observe changes in compartmentalization or barrier properties that might alter hormone diffusion in disease states?"], "functions": ["Is there a visible feature that provides physical support and separation from surrounding tissues for the adrenal gland?", "Does the image show a structure that serves as a protective outer layer for an endocrine gland?", "Does the image show a feature that might participate in tissue repair or modulate inflammation in response to injury or stress around the adrenal gland?"]}}, "spleen": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure in the image that measures between 11 and 14 centimeters in length?", "Can you identify an object that typically weighs around 150 to 200 grams in a healthy adult?", "Does the image show an ovoid or wedge-shaped anatomical structure?", "Is there a region with a deep purplish-red coloration visible?", "Can you see a structure that appears soft and friable in texture?", "Is there an object whose estimated volume is between 150 and 250 milliliters?", "Does the image contain a region likely to be composed of lymphocytes, macrophages, and reticular cells?", "Can you identify a structure that would be expected to have about 75% water content by weight?", "Is there an object that could contain iron at a concentration of 0.5 to 1.5 milligrams per gram of tissue?", "Does the image show a structure that would maintain a pH close to 7.4?", "Can you see an anatomical region with a density around 1.05 grams per cubic centimeter?", "Is there a structure that might contain approximately 18% protein and 2% lipid by wet weight?", "Can you identify an object whose temperature would match core body temperature, about 37 degrees Celsius?", "Does the image show a structure that lacks distinct lobules but may be divided into white and red pulp regions?", "Is there a region surrounded by a capsule and traversed by trabeculae, with connective tissue making up about 7% of its mass?", "Can you see a structure likely to contain enzymes such as acid phosphatase, catalase, and peroxidase?", "Is there an object in the image where the oxygen level is expected to be lower than arterial blood, around 40 mmHg?", "Does the image contain a region where the glucose concentration would be similar to venous blood, about 70 to 110 mg/dL?", "Can you identify a structure that could hold approximately 200 to 350 milliliters of blood?"], "relational": ["Does the image contain a structure that is part of the lymphatic system?", "Can you identify an organ located in the left upper quadrant of the abdominal cavity?", "Is there a structure situated near the stomach, left kidney, or pancreas?", "Does the image show an organ connected to the splenic artery or splenic vein?", "Can you see a structure supported by the splenorenal or gastrosplenic ligament?", "Is there evidence of tissues resembling white pulp or red pulp?", "Does the image contain an area rich in lymphocytes, macrophages, or dendritic cells?", "Can you identify a secondary lymphoid organ within the lymphatic system?", "Is there a structure associated with vascular channels such as sinusoids, but not directly with ducts?", "Does the image show an organ that interacts with lymph nodes, bone marrow, or thymus in immune responses?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for filtering blood and removing aged or abnormal blood cells?", "Is there an organ present that participates in immune surveillance and initiates immune responses against blood-borne antigens?", "Can you identify a region in the image that contains both red pulp and white pulp?", "Does the image include a structure where lymphocytes are activated and immune responses are initiated?", "Is there evidence of phagocytic activity by macrophages in a particular region of the tissue?", "Can you see an area that serves as a reservoir for platelets or red blood cells?", "Is there a structure that facilitates the maturation and proliferation of lymphocytes within a specialized region?", "Does the image contain evidence of a site where pathogens are filtered from circulation and adaptive immunity is initiated?", "Can you identify a region involved in breaking down senescent red blood cells and recycling iron to the bone marrow?", "Is there a structure that provides an environment for B lymphocyte activation and differentiation into plasma cells?", "Does the image show an organ that regulates the balance of white blood cells and platelets by sequestering and releasing them as needed?", "Can you see evidence of increased lymphocyte proliferation and antibody synthesis in response to infection?", "Is there a region where cellular debris is removed from the blood by macrophages?"]}, "no_questions": {"contexual_properties": ["Is there increased polymerization of cytoskeletal filaments in regions suggestive of smooth muscle contraction or tissue repair?", "Does the image show increased staining in areas undergoing wound healing or fibrosis?", "Is there increased signal in regions that could be associated with organ fibrosis, atherosclerosis, or cancerous growths?"], "properties": ["Does the image suggest the presence of a protein with an isoelectric point near 5.3?", "Does the image contain a protein composed of approximately 375 amino acids?", "Can you identify a protein whose secondary structure is mainly alpha helices with some beta strands and loops?"], "relational": ["Does the image contain anatomical features such as arterial walls, bronchioles, or the intestinal muscularis?", "Can you see fibers that might contribute to contractility within muscle tissue?", "Are there components in the image that could be part of the cardiovascular, respiratory, digestive, or reproductive systems?"], "contexual_behavior": ["Is there evidence of abnormal smooth muscle cell proliferation or altered cytoskeletal organization, as seen in tumors like leiomyosarcoma?", "Are there regions where smooth muscle cells appear dedifferentiated, suggesting a loss of contractile phenotype?", "Can you detect regions where myofibroblast differentiation may have been induced by transforming growth factor-beta signaling?"], "functions": ["Is there visual evidence of smooth muscle contraction that could regulate vascular tone?", "Are there features that suggest smooth muscle cell differentiation or myogenesis?", "Are there indications of cell movement or migration, possibly due to cytoskeletal rearrangement?"]}}, "abdomen": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region whose length appears to be within the typical adult range of 30 to 40 centimeters?", "Can you identify an area with a circumference that could be estimated between 80 and 100 centimeters in an adult?", "Is there a structure with an oval or rounded shape consistent with healthy individuals?", "Does the skin in the depicted area match the individual's overall skin tone, showing variation in pigmentation?", "Can you observe a region where the skin appears smooth and supple?", "Is there evidence of a wall-like structure with a thickness that could range from 1.5 to 3 centimeters, depending on visible fat and muscle layers?", "Does the area display characteristics suggesting a fat content that might constitute 15% to 30% of its mass?", "Can you see features indicating the presence of major muscles such as the rectus abdominis, obliques, or transversus abdominis?", "Is there a visible region where the water content could be estimated at around 60% of the tissue mass?", "Does the tissue in the area appear to have a density similar to other soft tissues, approximately 1.05 grams per cubic centimeter?", "Can you infer that the skin in this region might have a slightly acidic pH, typically between 4.5 and 5.5?", "Is there visual evidence suggesting that the skin's elasticity is high, possibly indicating youth, or decreased, suggesting older age?", "Does the distribution of hair in the area appear sparse, with possible variation by sex and more prominent hair in the midline for some males?", "Can you observe features that might indicate substantial collagen content in the skin, contributing to its strength and elasticity?"], "relational": ["Does the image show a region containing organs from the digestive, urinary, or reproductive systems?", "Can you identify an area that includes structures such as the stomach, liver, or kidneys?", "Is there a visible region that could be divided into quadrants like the right upper or left lower quadrant?", "Does the image display boundaries formed by the diaphragm or abdominal wall muscles?", "Can you see muscles such as the rectus abdominis or external oblique forming part of a wall?", "Is there evidence of major blood vessels like the abdominal aorta or inferior vena cava supplying a central region?", "Does the image show nerves such as the vagus nerve or lumbar plexus innervating a specific area?", "Can you identify cavities such as the peritoneal cavity or retroperitoneal space within the depicted region?", "Is there a structure supported by ligaments like the falciform or gastrosplenic ligament?", "Does the image depict a region that is anatomically continuous with the pelvis, forming part of the abdominopelvic cavity?"], "contexual_behavior": ["Does the image show a region that might display reduced muscular activity, as seen in neuromuscular disorders or muscle paralysis?", "Is there evidence of increased pressure in a body area that could be due to pregnancy and uterine expansion?", "Can you identify a region where the protective barrier for internal organs appears compromised, possibly from trauma or injury?", "Does the image suggest impaired peristaltic movement, which might occur in gastrointestinal disorders such as ileus?", "Is there visible distension that could be explained by fluid accumulation, as seen in ascites?", "Does the image show a region where increased intra-abdominal pressure might result from heavy lifting or muscle contraction?", "Can you see signs of decreased postural support, potentially due to muscle weakness as in sarcopenia or muscular dystrophy?", "Is there a region where muscle contraction appears prominent, as might occur during forced exhalation?", "Does the image reveal any protrusion of internal organs that could indicate herniation through a weakened wall?", "Is there a visible area where reduced motility or digestive activity might be inferred, as during fasting?", "Can you identify a region where loss of muscle or fat padding may have diminished its protective function, as seen in severe malnutrition?", "Does the image suggest increased muscular tension or guarding, possibly as a reflex to pain or underlying inflammation?", "Is there evidence of altered muscle coordination or straining that could affect defecation, as in constipation?", "Can you see signs of increased tenderness, rigidity, or reduced movement that might indicate an inflammatory condition such as peritonitis?", "Does the image suggest decreased support for pelvic organs, which could be due to aging-related decline in connective tissue and muscle strength?"], "functions": ["Does the image show a cavity that houses vital organs involved in digestion and movement?", "Can you identify a region containing structures such as the stomach, intestines, or liver that are responsible for nutrient absorption?", "Is there evidence of muscular or connective tissue layers that protect internal organs from external injury?", "Does the image include muscles whose contraction and relaxation could influence diaphragmatic movement and assist in breathing?", "Can you see anatomical features that provide core stability or enable trunk flexion and rotation?", "Is there a region where muscle contraction could regulate internal pressure, supporting actions like lifting or the Valsalva maneuver?", "Does the image contain structures such as the intestines or rectum that are involved in transporting and expelling waste?", "Can you identify features that might generate force through muscle contractions to assist in childbirth or delivery?", "Is there evidence of lymphatic tissue or cells that could participate in immune defense against pathogens?", "Does the image show major blood vessels, such as the abdominal aorta or portal vein, supplying digestive organs?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there a structure composed of endothelium, smooth muscle, or connective tissue visible in the image?", "Is there a visible interaction between a tubular structure and the nervous, musculoskeletal, or lymphatic systems?", "Is there evidence of a continuous circuit for blood or lymph transport involving the heart?"], "contexual_behavior": [], "functions": ["Can you identify a component that helps prevent blood loss after injury by supporting clot formation or initiating vasoconstriction?", "Is there a feature that supports wound healing by supplying nutrients, oxygen, and immune cells to an injury site?", "Does the image show a structure responsible for transporting blood, nutrients, or gases throughout the body?"]}}}
[ { "answer": "yes", "extracted_concepts": [ "spleen" ], "question": "does this image show spleen, normal?" }, { "answer": "no", "extracted_concepts": [ "cervix duplication", "spleen" ], "question": "does cervix duplication show spleen, normal?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "hematologic" ], "question": "is hematologic present?" }, { "answer": "no", "extracted_concepts": [ "nodule" ], "question": "is nodule present?" }, { "answer": "spleen", "extracted_concepts": [ "spleen" ], "question": "where is this part in?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" } ]	["cervix duplication", "spleen", "nodule", "hematologic"]	{"cervix duplication": {"yes_questions": {"contexual_properties": ["Does the image show evidence of a congenital anomaly that becomes more apparent during reproductive age or when evaluating for uterine abnormalities?", "Can you identify duplicated structures that display changes in tissue composition suggestive of infection or neoplastic processes?", "Is there an abnormal size difference between paired cervical structures that could be explained by hormonal changes, inflammation, or congenital variation?", "Do the duplicated cervical regions exhibit differences in color that might indicate localized infection, ischemia, or trauma?", "Is there visible structural asymmetry between two cervical-like structures that could be due to an underlying M\u00fcllerian duct anomaly or secondary pathology?", "Can you observe alterations in the shape of the cervical canal that might be associated with uterine malformations or scarring?", "Do any of the duplicated cervical areas show abnormal epithelial thickness, possibly due to chronic inflammation, hormonal imbalance, or dysplasia?", "Is there increased vascularity in either of the duplicated cervical regions, which could be related to pregnancy, inflammation, or neoplastic changes?", "Can you detect differences in mucosal texture between two cervical-like structures, potentially resulting from chronic irritation, infection, or hormonal changes?", "Is there evidence of abnormal cervical mucus production in either of the duplicated regions, possibly associated with ovulation, infection, or hormonal disorders?", "Do the duplicated cervical structures show changes in tissue density that might suggest fibrosis, edema, or neoplastic infiltration?", "Is there swelling or edema present in one or both of the cervical-like structures, possibly as a response to infection, trauma, or allergic reaction?", "Are there differences in cervical length between duplicated structures that could be attributed to asymmetric development or a history of surgical procedures?", "Can you observe abnormal cellular morphology in either of the duplicated cervical regions, which might indicate dysplasia, neoplasia, or chronic infection?", "Is there evidence suggesting an increased risk of cervical stenosis in the duplicated cervical structures following surgical intervention, infection, or congenital malformation?"], "properties": ["Does the image show two distinct cylindrical or barrel-shaped structures within the female reproductive tract?", "Can you identify a case where there are two separate cervical canals present?", "Is there evidence of a septum or partial division between two cervical structures?", "Do the two structures each appear to measure between 2.5 and 3.5 centimeters in length?", "Are the duplicated structures positioned a few millimeters to 1\u20132 centimeters apart from each other?", "Can you see features suggesting the presence of smooth muscle, connective tissue, and mucosal lining in both structures?", "Is there visual indication of non-keratinized stratified squamous epithelium on the outer surface and simple columnar epithelium lining the canal of each structure?", "Do both structures display a pink or pale pink coloration consistent with healthy cervical tissue?", "Is there evidence that each structure receives blood supply from branches of the uterine arteries, similar to a typical cervix?", "Can you observe two structures with normal epithelial and stromal architecture?", "Do both structures appear to have a muscular layer thickness of approximately 3\u20135 millimeters?", "Is there visual evidence of numerous endocervical glands within the mucosa of each structure?", "Do both structures show signs of collagen-rich stroma providing structural support?", "Is there indication that each structure is capable of producing cervical mucus independently?"], "relational": ["Does the image show evidence of an anomaly affecting the female reproductive system?", "Can you identify more than one structure resembling the lower part of the uterus or the upper part of the vaginal canal?", "Is there a visible duplication of anatomical features between the uterus and the vagina?", "Does the image reveal two separate passages or openings in the region typically occupied by the cervical canal?", "Can you see adjacent organs such as the bladder or rectum near duplicated structures in the reproductive tract?", "Is there evidence of a longitudinal septum dividing the vaginal canal?", "Does the image suggest the presence of a double uterus or bicornuate uterus?", "Can you identify tissues such as stratified squamous epithelium or smooth muscle in more than one cervical-like structure?", "Is there a duplicated structure, each connected to its own uterine cavity or vaginal canal?", "Does the image display features consistent with M\u00fcllerian duct anomalies or uterine malformations?", "Can you observe any signs of a double vagina or other vaginal anomalies associated with reproductive tract duplication?", "Is there any indication of renal agenesis or other anomalies commonly linked to duplications in the reproductive system?"], "contexual_behavior": [], "functions": ["Does the image show an anatomical variation in the reproductive tract that could impact pregnancy or delivery outcomes?", "Is there evidence of two cervical canals that might alter menstrual flow patterns or regulation?", "Can you identify a structural feature that could create anatomical barriers or alter sperm transport, potentially affecting fertility or conception?", "Does the image reveal two cervical openings that might influence sperm migration to the uterus?", "Is there a reproductive tract configuration that could increase the risk of obstructed labor or require special management during childbirth?", "Can you see an arrangement that might alter the cervix\u2019s protective barrier function by introducing an additional canal, potentially affecting defense against pathogens?", "Is there a feature present that could increase susceptibility to infections by providing two possible entry points for pathogens?", "Does the image suggest a disruption in normal cervical mucus drainage, such as retention or abnormal flow?", "Is there a scenario where cervical screening or disease detection could be complicated by the need to examine more than one cervical structure, increasing the risk of missed lesions?"]}, "no_questions": {"contexual_properties": ["Can you identify a tube-like feature that is adherent to an adjacent ovarian structure across from it?", "Is there a tubular structure in the image that appears to be attached to an ovary located on the opposite side?", "Does the image show a tube that is in close contact with an ovary on the other side of the field?"], "properties": ["Can you identify a tube-like feature that is visually adherent to an adjacent ovarian structure on the contralateral side?", "Is there a tubular structure in the image that appears to be attached to an ovary located on the opposite side?", "Does the image show a tube in close association with an ovary that is positioned on the other side of the body or field of view?"], "relational": ["Can you identify a structure in proximity to the ovary, uterus, bladder, or rectum?", "Is there a tube in the image that could receive blood supply from the ovarian or uterine arteries?", "Can you identify a tube-like structure in the adnexal or pelvic region that is connected to both the uterus and the ovary?"], "contexual_behavior": ["Is there evidence of a tubular structure whose movement is restricted by adhesions to a nearby ovary, potentially impairing ovum transport?", "Is there a tubular structure near an ovary that appears altered by adhesions or scarring, increasing the risk of ectopic implantation?", "Can you identify a tube adjacent to an ovary that appears distorted or immobile, suggesting possible tubal dysfunction?"], "functions": ["Does the image include a tube-like structure that may respond to hormonal changes, such as fluctuations in estrogen or progesterone during the menstrual cycle?", "Does the image show a structure adjacent to an ovary that is involved in transporting eggs?", "Can you identify a feature that could maintain an optimal environment for fertilization, such as by regulating pH or producing secretions?"]}}, "spleen": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure in the image that measures between 11 and 14 centimeters in length?", "Can you identify an object that typically weighs around 150 to 200 grams in a healthy adult?", "Does the image show an ovoid or wedge-shaped anatomical structure?", "Is there a region with a deep purplish-red coloration visible?", "Can you see a structure that appears soft and friable in texture?", "Is there an object whose estimated volume is between 150 and 250 milliliters?", "Does the image contain a region likely to be composed of lymphocytes, macrophages, and reticular cells?", "Can you identify a structure that would be expected to have about 75% water content by weight?", "Is there an object that could contain iron at a concentration of 0.5 to 1.5 milligrams per gram of tissue?", "Does the image show a structure that would maintain a pH close to 7.4?", "Can you see an anatomical region with a density around 1.05 grams per cubic centimeter?", "Is there a structure that might contain approximately 18% protein and 2% lipid by wet weight?", "Can you identify an object whose temperature would match core body temperature, about 37 degrees Celsius?", "Does the image show a structure that lacks distinct lobules but may be divided into white and red pulp regions?", "Is there a region surrounded by a capsule and traversed by trabeculae, with connective tissue making up about 7% of its mass?", "Can you see a structure likely to contain enzymes such as acid phosphatase, catalase, and peroxidase?", "Is there an object in the image where the oxygen level is expected to be lower than arterial blood, around 40 mmHg?", "Does the image contain a region where the glucose concentration would be similar to venous blood, about 70 to 110 mg/dL?", "Can you identify a structure that could hold approximately 200 to 350 milliliters of blood?"], "relational": ["Does the image contain a structure that is part of the lymphatic system?", "Can you identify an organ located in the left upper quadrant of the abdominal cavity?", "Is there a structure situated near the stomach, left kidney, or pancreas?", "Does the image show an organ connected to the splenic artery or splenic vein?", "Can you see a structure supported by the splenorenal or gastrosplenic ligament?", "Is there evidence of tissues resembling white pulp or red pulp?", "Does the image contain an area rich in lymphocytes, macrophages, or dendritic cells?", "Can you identify a secondary lymphoid organ within the lymphatic system?", "Is there a structure associated with vascular channels such as sinusoids, but not directly with ducts?", "Does the image show an organ that interacts with lymph nodes, bone marrow, or thymus in immune responses?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for filtering blood and removing aged or abnormal blood cells?", "Is there an organ present that participates in immune surveillance and initiates immune responses against blood-borne antigens?", "Can you identify a region in the image that contains both red pulp and white pulp?", "Does the image include a structure where lymphocytes are activated and immune responses are initiated?", "Is there evidence of phagocytic activity by macrophages in a particular region of the tissue?", "Can you see an area that serves as a reservoir for platelets or red blood cells?", "Is there a structure that facilitates the maturation and proliferation of lymphocytes within a specialized region?", "Does the image contain evidence of a site where pathogens are filtered from circulation and adaptive immunity is initiated?", "Can you identify a region involved in breaking down senescent red blood cells and recycling iron to the bone marrow?", "Is there a structure that provides an environment for B lymphocyte activation and differentiation into plasma cells?", "Does the image show an organ that regulates the balance of white blood cells and platelets by sequestering and releasing them as needed?", "Can you see evidence of increased lymphocyte proliferation and antibody synthesis in response to infection?", "Is there a region where cellular debris is removed from the blood by macrophages?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Can you see a structure positioned close to the fallopian tube, which would receive an ovulated oocyte?", "Does the image contain a region composed mainly of granulosa lutein cells or theca lutein cells?", "Can you see an area that appears to receive blood supply from branches of the ovarian artery?"], "contexual_behavior": [], "functions": ["Can you identify an object that prepares the uterus for implantation by thickening and stabilizing the endometrial lining?", "Is there an object present that supports early pregnancy by secreting hormones?", "Can you see a structure that sustains the uterine lining for embryo implantation?"]}}, "nodule": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a small lesion in the image that measures less than 3 centimeters in diameter?", "Can you identify a structure with a round or oval appearance?", "Does the image show an object whose color is similar to the surrounding tissue or appears pale?", "Is there a structure that could be either soft or firm in consistency?", "Can you see an area that might be solid, cystic, or have mixed density?", "Is there a feature composed of cells, extracellular matrix, or possibly containing fluid or calcifications?", "Does the image contain an object with a smooth or irregular surface texture?", "Can you find a structure with well-defined or ill-defined margins?", "On ultrasound, is there a region that appears hypoechoic, isoechoic, or hyperechoic compared to adjacent tissue?", "On CT imaging, is there a small area with low, intermediate, or high attenuation?", "Can you identify a structure that shows punctate or coarse calcification, or lacks calcification entirely?", "Is there an area that appears avascular, hypovascular, or hypervascular?", "Does the image show a lesion that appears to have grown slowly or has a variable growth rate?", "Can you see a structure with a homogeneous or heterogeneous internal pattern?", "Is there an object that might feel firm, soft, or rubbery if palpated?", "Can you identify a region that could have high water content, such as a cystic area?", "Is there a small structure with low lipid content, unless it appears to be of adipose origin?", "Does the image show an area where protein concentration might be high due to cellular or matrix components?", "Can you see a region whose temperature would likely match that of the surrounding tissue unless there are signs of inflammation?"], "relational": ["Is there a localized mass present within epithelial, connective, or glandular tissue in the image?", "Can you identify a focal lesion associated with organs such as the thyroid, lung, liver, or skin?", "Does the image show a structure situated in regions like the neck, lungs, breast, or subcutaneous tissue?", "Is there an embedded structure adjacent to blood vessels, nerves, or surrounding parenchyma?", "Can you see a mass containing cell types such as epithelial cells, fibroblasts, inflammatory cells, or neoplastic cells?", "Is there a visible structure that appears as a focal lesion within or attached to the surrounding tissue?", "Does the image contain a mass that is part of a larger anatomical structure such as an organ, lobe, or gland?", "Can you identify a structural component that may belong to the endocrine, respiratory, or integumentary system?", "Is there a mass with arteries, veins, lymphatic vessels, or ducts passing near or connected to it?", "Does the image show a localized structure situated in the dermis, subcutaneous layer, parenchyma, or mucosa?"], "contexual_behavior": ["Does the image show a structure that could increase hormone secretion in response to stimulation, as seen in hyperfunctioning endocrine conditions?", "Is there an area that appears to fail in regulating local tissue metabolism, possibly due to disrupted cellular composition or signaling?", "Can you identify a region that might impair organ function by causing local edema, cellular infiltration, or compressing nearby structures?", "Does the image contain a feature that could indicate altered signaling activity, suggestive of malignant transformation or abnormal growth communication?", "Is there evidence of reduced secretory function in a region where fibrosis or increased extracellular matrix deposition has replaced functional cells?", "Can you see a structure with increased vascularization, possibly due to hypoxic conditions and upregulation of angiogenic factors?", "Is there a part of the tissue where normal architecture appears disrupted, potentially due to rapid cellular proliferation outpacing supporting stroma?", "Does the image reveal an area with decreased metabolic activity, which might indicate a response to therapy or reduced cellular viability?", "Can you identify a region showing signs of abnormal cell proliferation, as might occur in pathological or neoplastic processes?", "Is there evidence of loss of homeostasis in a localized area, possibly due to infection and immune cell infiltration?", "Does the image show a site with enhanced local immune response, such as lymphocytic infiltration and cytokine production in autoimmune disease?", "Is there a region where normal tissue function appears suppressed, potentially due to exposure to toxins or necrosis?", "Can you see a structure with altered endocrine activity, possibly resulting from disrupted feedback mechanisms and hormonal imbalance?", "Is there an area that seems unresponsive to regulatory signals, which could be due to chronic disease and desensitized receptors or pathways?", "Does the image reveal increased extracellular matrix production in response to injury, such as activation of fibroblasts and collagen deposition?"], "functions": ["Does the image show a localized mass that could indicate abnormal tissue growth or a response to injury?", "Is there evidence of a structure that disrupts normal tissue architecture or impairs the function of the surrounding tissue?", "Can you identify a region that might be associated with inflammation, fibrosis, or neoplastic transformation?", "Is there a visible area where increased cell proliferation, immune cell recruitment, or extracellular matrix deposition could be occurring?", "Does the image contain a site that could contribute to disease progression, such as persistent inflammation, tumor development, or organ dysfunction?", "Is there a structure that appears to attract immune cells or modulate local immune responses?", "Can you see an area that might compromise organ function by obstructing normal tissue pathways or altering physiological processes?", "Is there a region supporting unchecked cellular proliferation or accumulation of extracellular material, suggesting abnormal tissue growth?", "Does the image show a formation that could signal tissue injury or a repair response to chronic damage?", "Is there a visible feature that might disrupt blood flow, alter secretion, or impede normal tissue interactions at its location?"]}, "no_questions": {"contexual_properties": [], "properties": ["Do any cells appear to have a high RNA content, suggestive of active transcription?", "Are there cells present that express markers associated with progenitor or biliary lineages?", "Can you see cells that are likely diploid, containing a normal 2N ploidy?"], "relational": ["Is there evidence of cells that are found near the portal triad or bile ductules?", "Does the image contain cells that interact with hepatic parenchyma or portal tracts?", "Is there a cell type present that can differentiate into hepatocytes during regeneration?"], "contexual_behavior": [], "functions": ["Is there visual evidence of cells responding to signals from the liver microenvironment, such as cytokines or growth factors?", "Does the image show cells that are actively involved in tissue repair or regeneration?", "Does the image contain cells that could be participating in tissue restoration by integrating into liver structures?"]}}, "hematologic": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image contain a sample composed of red blood cells, white blood cells, platelets, and plasma?", "Can you identify a specimen that typically appears red in color?", "Is there evidence of a fluid with a viscosity between 3 and 4 centipoise at 37\u00b0C?", "Does the image show a sample whose pH would be expected to fall between 7.35 and 7.45?", "Can you see a sample that might have a density around 1.050 to 1.060 g/mL?", "Is there a specimen that would normally be collected in a volume between 2 and 10 mL for analysis?", "Does the image include a sample that could be assessed for hemoglobin concentration in the range of 12.0\u201317.5 g/dL depending on sex?", "Can you identify a sample where the hematocrit value might be between 36% and 53%?", "Is there a structure that would be expected to have a red blood cell count within the typical range for males or females?", "Does the image show a specimen that could be evaluated for a white blood cell count between 4,000 and 11,000 cells/\u03bcL?", "Can you see a sample that would be expected to contain 150,000 to 450,000 platelets per microliter?", "Is there a sample present that could have a mean corpuscular volume (MCV) between 80 and 100 fL?", "Does the image include a specimen where the mean corpuscular hemoglobin concentration (MCHC) might be 32\u201336 g/dL?", "Can you identify a sample that could have a mean corpuscular hemoglobin (MCH) of 27\u201333 pg/cell?", "Is there a specimen that would be expected to have an iron level between 60 and 170 \u03bcg/dL?", "Does the image show a sample that could have a fasting glucose concentration of 70\u201399 mg/dL?", "Can you see a specimen with a protein content typically between 6 and 8 g/dL?", "Is there a sample that would be expected to have a sodium concentration of 135\u2013145 mmol/L?", "Does the image include a specimen where the potassium concentration might be 3.5\u20135.0 mmol/L?", "Can you identify a sample that could have a calcium concentration between 8.5 and 10.5 mg/dL?"], "relational": ["Does the image show any structures that are part of the circulatory or immune systems?", "Can you identify an organ such as the bone marrow, spleen, or thymus?", "Is there evidence of hematopoietic or lymphoid tissue present?", "Does the image contain cells like red blood cells, white blood cells, or platelets?", "Are there visible blood vessels, lymph nodes, or the heart in the image?", "Can you see anatomical features that participate in immunity, fluid balance, or cell production?", "Is there a body fluid such as blood, plasma, or serum depicted?", "Does the image include regions like the bone marrow, spleen, lymph nodes, or bloodstream?", "Are arteries, veins, or capillaries visible in the image?", "Can you identify organs that contribute to the formation of blood components, such as the bone marrow, liver, or spleen?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a process responsible for transporting oxygen in the body?", "Can you identify structures or cells involved in immune defense, such as those producing antibodies or performing phagocytosis?", "Is there visual indication of mechanisms that facilitate blood clotting, like platelet activation or fibrin formation?", "Does the image include features related to the production of blood cells, such as hematopoiesis occurring in bone marrow?", "Can you see evidence of waste removal from the blood, such as the transport of metabolic byproducts or carbon dioxide?", "Is there a visible indication of processes that help maintain pH balance, possibly through buffering by plasma proteins or hemoglobin?", "Does the image show a response to infection or injury, such as activation of leukocytes or the presence of inflammatory mediators?", "Can you identify features related to the regulation of bleeding, such as vasoconstriction or platelet plug formation?", "Is there evidence of nutrient transport in the bloodstream, such as the movement of glucose, amino acids, or lipids?", "Does the image display signs of inflammation, like the mobilization of leukocytes or acute phase proteins?", "Can you observe features that suggest maintenance of blood volume, such as regulation by plasma proteins or erythrocyte mass?", "Is there visual evidence of the removal of old or damaged blood cells, such as phagocytosis by macrophages in organs like the spleen or liver?"]}, "no_questions": {"contexual_properties": ["Is there a mass in the image that appears to have increased in size, suggesting unchecked cell division or progression?", "Is there evidence of increased proliferation markers, such as high Ki-67 expression, in any lesion?", "Is there a lesion with areas of altered color, such as those caused by hemorrhage, necrosis, or treatment effects?"], "properties": ["Does the tumor appear in a patient who is younger than typical for other breast cancer subtypes, such as around 40 to 50 years old?", "Is there a prominent stromal component or evidence of desmoplastic reaction in the tumor?", "Can you observe moderate to high levels of necrosis within the tumor mass?"], "relational": ["Can you identify epithelial or basal-like tumor cells in the sample?", "Is there a tumor present that lacks visible expression of estrogen receptor, progesterone receptor, and HER2?", "Can you observe a high mitotic index or basal-like morphology in the tumor cells?"], "contexual_behavior": [], "functions": ["Does the tumor microenvironment show signs of stromal cell recruitment or increased inflammation?", "Does any tumor in the image appear to lack hormone receptor expression, potentially indicating resistance to endocrine therapies?", "Is there evidence of alternative growth pathways being utilized by any of the cancerous tissues?"]}}}
[ { "answer": "yes", "extracted_concepts": [ "spleen" ], "question": "does this image show spleen, normal?" }, { "answer": "no", "extracted_concepts": [ "spleen", "acrocyanosis" ], "question": "does acrocyanosis show spleen, normal?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [], "question": "is hematologic present?" }, { "answer": "no", "extracted_concepts": [ "hemorrhagic corpus luteum" ], "question": "is hemorrhagic corpus luteum present?" }, { "answer": "spleen", "extracted_concepts": [ "spleen" ], "question": "where is this part in?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" } ]	["hematologic", "hemorrhagic corpus luteum", "spleen", "acrocyanosis"]	{"hematologic": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image contain a sample composed of red blood cells, white blood cells, platelets, and plasma?", "Can you identify a specimen that typically appears red in color?", "Is there evidence of a fluid with a viscosity between 3 and 4 centipoise at 37\u00b0C?", "Does the image show a sample whose pH would be expected to fall between 7.35 and 7.45?", "Can you see a sample that might have a density around 1.050 to 1.060 g/mL?", "Is there a specimen that would normally be collected in a volume between 2 and 10 mL for analysis?", "Does the image include a sample that could be assessed for hemoglobin concentration in the range of 12.0\u201317.5 g/dL depending on sex?", "Can you identify a sample where the hematocrit value might be between 36% and 53%?", "Is there a structure that would be expected to have a red blood cell count within the typical range for males or females?", "Does the image show a specimen that could be evaluated for a white blood cell count between 4,000 and 11,000 cells/\u03bcL?", "Can you see a sample that would be expected to contain 150,000 to 450,000 platelets per microliter?", "Is there a sample present that could have a mean corpuscular volume (MCV) between 80 and 100 fL?", "Does the image include a specimen where the mean corpuscular hemoglobin concentration (MCHC) might be 32\u201336 g/dL?", "Can you identify a sample that could have a mean corpuscular hemoglobin (MCH) of 27\u201333 pg/cell?", "Is there a specimen that would be expected to have an iron level between 60 and 170 \u03bcg/dL?", "Does the image show a sample that could have a fasting glucose concentration of 70\u201399 mg/dL?", "Can you see a specimen with a protein content typically between 6 and 8 g/dL?", "Is there a sample that would be expected to have a sodium concentration of 135\u2013145 mmol/L?", "Does the image include a specimen where the potassium concentration might be 3.5\u20135.0 mmol/L?", "Can you identify a sample that could have a calcium concentration between 8.5 and 10.5 mg/dL?"], "relational": ["Does the image show any structures that are part of the circulatory or immune systems?", "Can you identify an organ such as the bone marrow, spleen, or thymus?", "Is there evidence of hematopoietic or lymphoid tissue present?", "Does the image contain cells like red blood cells, white blood cells, or platelets?", "Are there visible blood vessels, lymph nodes, or the heart in the image?", "Can you see anatomical features that participate in immunity, fluid balance, or cell production?", "Is there a body fluid such as blood, plasma, or serum depicted?", "Does the image include regions like the bone marrow, spleen, lymph nodes, or bloodstream?", "Are arteries, veins, or capillaries visible in the image?", "Can you identify organs that contribute to the formation of blood components, such as the bone marrow, liver, or spleen?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a process responsible for transporting oxygen in the body?", "Can you identify structures or cells involved in immune defense, such as those producing antibodies or performing phagocytosis?", "Is there visual indication of mechanisms that facilitate blood clotting, like platelet activation or fibrin formation?", "Does the image include features related to the production of blood cells, such as hematopoiesis occurring in bone marrow?", "Can you see evidence of waste removal from the blood, such as the transport of metabolic byproducts or carbon dioxide?", "Is there a visible indication of processes that help maintain pH balance, possibly through buffering by plasma proteins or hemoglobin?", "Does the image show a response to infection or injury, such as activation of leukocytes or the presence of inflammatory mediators?", "Can you identify features related to the regulation of bleeding, such as vasoconstriction or platelet plug formation?", "Is there evidence of nutrient transport in the bloodstream, such as the movement of glucose, amino acids, or lipids?", "Does the image display signs of inflammation, like the mobilization of leukocytes or acute phase proteins?", "Can you observe features that suggest maintenance of blood volume, such as regulation by plasma proteins or erythrocyte mass?", "Is there visual evidence of the removal of old or damaged blood cells, such as phagocytosis by macrophages in organs like the spleen or liver?"]}, "no_questions": {"contexual_properties": ["Can you identify areas where protein aggregates are larger, suggesting advanced stages of pathology or persistent misfolding?", "Can you observe structural differences in aggregates that might be explained by genetic mutations, post-translational modifications, or environmental influences?", "Is there evidence of fragmented deposits, suggesting proteolytic activity or mechanical disruption?"], "properties": [], "relational": ["Is there visible deposition in cerebral blood vessels, parenchyma, or meninges?", "Can you identify changes in regions such as the cerebral cortex, hippocampus, or basal ganglia?", "Are there anatomical relationships to structures such as the spinal cord, brainstem, or thalamus?"], "contexual_behavior": [], "functions": ["Can you observe signs that may correlate with cognitive impairment, such as memory loss or learning deficits?", "Can you identify regions where amyloid deposition is present in the brain?", "Does the image show evidence of abnormal protein aggregation within neural tissue?"]}}, "hemorrhagic corpus luteum": {"yes_questions": {"contexual_properties": ["Does the image show a structure within the ovary that appears to contain blood or evidence of recent bleeding?", "Can you identify an ovarian feature that may represent a temporary endocrine gland with hemorrhagic characteristics?", "Is there a visible ovarian structure that could be involved in the menstrual cycle and shows signs of internal hemorrhage?", "Does the image contain an ovarian entity that might be responsible for progesterone production and appears to have blood-filled areas?"], "properties": ["Is there a round or oval structure measuring between 2 and 5 centimeters in diameter visible in the image?", "Can you identify an object with a reddish-brown appearance, possibly due to the presence of blood?", "Does the image show a structure with a soft and spongy texture, possibly containing areas of clot?", "Is there a cystic cavity present that contains both blood and fibrin strands?", "Can you see a structure whose wall thickness appears to be between 2 and 6 millimeters?", "Does the image reveal an object with a volume that could be estimated between 2 and 10 milliliters?", "Is there a structure composed of cell types such as luteinized granulosa cells, theca lutein cells, endothelial cells, and red blood cells?", "Can you identify an area containing both serous fluid and blood within a cystic cavity?", "Does the image show a complex cyst with mixed echogenicity and reticular internal echoes, as might be seen on ultrasound?", "Is there evidence of significant blood content, such as fresh or clotted blood, within a cystic structure?", "Can you see a structure with a thickened wall and internal fibrin strands?", "Is there an object whose average weight could be estimated between 2 and 8 grams?", "Does the image include a structure that typically persists for about 2 to 3 weeks?"], "relational": ["Does the image show a structure that is part of the female reproductive system?", "Can you identify an object located within the ovary?", "Is there a region surrounded by ovarian cortical tissue and stroma?", "Does the image contain a structure adjacent to developing follicles or the ovarian medulla?", "Can you see blood vessels such as branches of the ovarian artery or surrounding capillaries near a particular structure?", "Is there an area containing granulosa lutein cells, theca lutein cells, and erythrocytes?", "Can you identify a structure that develops from an ovarian follicle following ovulation?", "Is there evidence of localized hemorrhage or enlargement within the ovary?", "Does the image show a structure that may interact with the endometrium or pituitary gland during the menstrual cycle?", "Is there an object contained within the pelvic cavity that fits these characteristics?"], "contexual_behavior": ["Does the image contain a structure that could represent a corpus luteum with evidence of bleeding or blood accumulation?", "Is there a visible ovarian structure that appears to have hemorrhagic features?", "Can you identify an area within the ovary that shows signs of recent or ongoing hemorrhage?", "Does the image show an ovarian entity with characteristics of both luteal tissue and blood?"], "functions": ["Does the image show a temporary ovarian structure involved in hormone secretion?", "Is there a feature present that produces progesterone and estrogen after ovulation?", "Can you identify a structure that supports the luteal phase of the menstrual cycle by preparing the endometrium for implantation?", "Is there evidence of a structure that maintains progesterone levels during early pregnancy to support the uterine lining?", "Does the image contain an object responsible for inducing secretory changes in the endometrium?", "Can you see a structure that contributes to ovarian tissue recovery at the site of follicle rupture?", "Is there a feature that plays a role in regulating hormonal balance and supporting implantation conditions?", "Does the image show a structure that prevents endometrial shedding by maintaining the uterine lining through progesterone production?"]}, "no_questions": {"contexual_properties": ["Does the contour of one side of the nose appear disrupted or irregular, potentially due to trauma, surgery, or tissue necrosis?", "Is there any deformation or abnormal shape of one side of the nose, possibly resulting from trauma, congenital anomaly, or tumor invasion?", "Do you see any nodules or masses on one lateral aspect of the nose that could represent a benign tumor, cyst, or malignancy?"], "properties": ["Is there a region containing layers such as skin, subcutaneous tissue, cartilage, bone, and mucosa?", "Can you see an area with a rich capillary network supporting both the skin and mucosa?", "Does the nasal structure include a section formed by the nasal bone and the frontal process of the maxilla?"], "relational": ["Is there a region supported by the frontal process of the maxilla on the left side?", "Can you see an area corresponding to the left nasal vestibule or left inferior meatus?", "Is there a visible structure composed of skin, subcutaneous tissue, cartilage, bone, and mucosa on the left side of the nose?"], "contexual_behavior": ["Can you identify a structure where filtering efficiency appears decreased, possibly due to particulate overload in a polluted environment?", "Is there a structure that might display impaired olfactory function due to inflammation or blockage from a sinus infection?", "Is there evidence of reduced airflow through a structure that could be affected by mucosal swelling or inflammation?"], "functions": ["Is there a structure in the image that participates in the passage of air and filtration of inhaled particles?", "Can you see a location where olfactory epithelium might be present for detecting odor molecules?", "Is there evidence of a vascularized mucosa that could warm incoming air via heat exchange?"]}}, "spleen": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure in the image that measures between 11 and 14 centimeters in length?", "Can you identify an object that typically weighs around 150 to 200 grams in a healthy adult?", "Does the image show an ovoid or wedge-shaped anatomical structure?", "Is there a region with a deep purplish-red coloration visible?", "Can you see a structure that appears soft and friable in texture?", "Is there an object whose estimated volume is between 150 and 250 milliliters?", "Does the image contain a region likely to be composed of lymphocytes, macrophages, and reticular cells?", "Can you identify a structure that would be expected to have about 75% water content by weight?", "Is there an object that could contain iron at a concentration of 0.5 to 1.5 milligrams per gram of tissue?", "Does the image show a structure that would maintain a pH close to 7.4?", "Can you see an anatomical region with a density around 1.05 grams per cubic centimeter?", "Is there a structure that might contain approximately 18% protein and 2% lipid by wet weight?", "Can you identify an object whose temperature would match core body temperature, about 37 degrees Celsius?", "Does the image show a structure that lacks distinct lobules but may be divided into white and red pulp regions?", "Is there a region surrounded by a capsule and traversed by trabeculae, with connective tissue making up about 7% of its mass?", "Can you see a structure likely to contain enzymes such as acid phosphatase, catalase, and peroxidase?", "Is there an object in the image where the oxygen level is expected to be lower than arterial blood, around 40 mmHg?", "Does the image contain a region where the glucose concentration would be similar to venous blood, about 70 to 110 mg/dL?", "Can you identify a structure that could hold approximately 200 to 350 milliliters of blood?"], "relational": ["Does the image contain a structure that is part of the lymphatic system?", "Can you identify an organ located in the left upper quadrant of the abdominal cavity?", "Is there a structure situated near the stomach, left kidney, or pancreas?", "Does the image show an organ connected to the splenic artery or splenic vein?", "Can you see a structure supported by the splenorenal or gastrosplenic ligament?", "Is there evidence of tissues resembling white pulp or red pulp?", "Does the image contain an area rich in lymphocytes, macrophages, or dendritic cells?", "Can you identify a secondary lymphoid organ within the lymphatic system?", "Is there a structure associated with vascular channels such as sinusoids, but not directly with ducts?", "Does the image show an organ that interacts with lymph nodes, bone marrow, or thymus in immune responses?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for filtering blood and removing aged or abnormal blood cells?", "Is there an organ present that participates in immune surveillance and initiates immune responses against blood-borne antigens?", "Can you identify a region in the image that contains both red pulp and white pulp?", "Does the image include a structure where lymphocytes are activated and immune responses are initiated?", "Is there evidence of phagocytic activity by macrophages in a particular region of the tissue?", "Can you see an area that serves as a reservoir for platelets or red blood cells?", "Is there a structure that facilitates the maturation and proliferation of lymphocytes within a specialized region?", "Does the image contain evidence of a site where pathogens are filtered from circulation and adaptive immunity is initiated?", "Can you identify a region involved in breaking down senescent red blood cells and recycling iron to the bone marrow?", "Is there a structure that provides an environment for B lymphocyte activation and differentiation into plasma cells?", "Does the image show an organ that regulates the balance of white blood cells and platelets by sequestering and releasing them as needed?", "Can you see evidence of increased lymphocyte proliferation and antibody synthesis in response to infection?", "Is there a region where cellular debris is removed from the blood by macrophages?"]}, "no_questions": {"contexual_properties": ["Does the image show evidence of fluid accumulation, as might occur in renal dysfunction or heart failure?", "Does the image show a body part that appears swollen, possibly indicating edema or heart failure?", "Is there visible discoloration that might be associated with vascular disorders or fungal infections?"], "properties": [], "relational": ["Is there a region that includes joints such as the ankle joint or metatarsophalangeal joints?", "Is there an area anatomically adjacent to the ankles and lower legs?", "Can you see a structure that is connected to the ankles through articulations or structural continuity?"], "contexual_behavior": ["Is there evidence of a body part that could lose its shock-absorbing ability due to fat pad atrophy or collapsed arches?", "Can you identify a structure that might become less responsive to proprioceptive input with aging?", "Is there a visible area that could experience decreased muscle activity during prolonged immobility?"], "functions": ["Is there an object that facilitates locomotion by enabling push-off and stride?", "Can you identify a structure that adapts to different surfaces by altering pressure distribution and adjusting joint angles?", "Does the image show an area involved in temperature regulation by dissipating heat through sweat glands?"]}}, "acrocyanosis": {"yes_questions": {"contexual_properties": ["Does the image show an area where skin color appears more intense or bluish in a cold environment?", "Is there a region where the skin displays a mottled or patchy appearance, suggesting uneven blood flow?", "Can you identify an area that looks swollen, possibly due to prolonged reduced circulation?", "Is there evidence of delayed capillary refill in any visible extremity, indicating poor perfusion?", "Does any part of the image suggest increased sweating or moisture in regions with color changes?", "Is there a visible area where the skin appears thicker, possibly due to chronic changes?", "Can you see a region that might feel colder to the touch, based on its appearance and context?", "Is there a part of the image where the skin color intensity varies with apparent temperature differences or emotional stress cues?", "Does any area appear to be affected by numbness, as suggested by posture or lack of movement?", "Is there a visible region where the affected area is larger, possibly due to more extensive or prolonged vasospasm?", "Can you identify an area where the skin color improves or returns to normal in regions that appear to be warmed?", "Is there evidence of peripheral cyanosis, such as bluish discoloration in the extremities?", "Does any region show signs of hyperhidrosis, such as excessive moisture in areas with color changes?", "Is there a visible indication of chronicity, such as persistent discoloration or skin changes in the same area?"], "properties": ["Does the image show areas of skin with a bluish or cyanotic appearance?", "Can you identify regions that appear cool or have decreased temperature compared to surrounding areas?", "Is there visible evidence of moist or sweaty skin in any of the extremities?", "Do you observe mild to moderate discoloration suggestive of cyanosis?", "Is there any indication that capillary refill time in the affected areas is normal or only slightly prolonged?", "Do the affected regions appear to have normal oxygen saturation based on visual cues?", "Is the color change in the skin persistent rather than transient?", "Are the discolored areas distributed symmetrically on the distal parts of the extremities?", "Does the image suggest that the skin changes are mild and not associated with ulceration or tissue damage?", "Is there evidence that the observed findings are more likely in an adolescent or young adult individual?"], "relational": ["Does the image show any regions of the body that are part of the cardiovascular, integumentary, or peripheral vascular systems?", "Are there visible changes in the fingers, toes, hands, or feet?", "Can you identify any signs involving small arteries, arterioles, capillaries, or venules in the extremities?", "Is there evidence of altered appearance in the dermis, subcutaneous tissue, or vascular endothelium of distal regions?", "Does the image suggest impaired peripheral circulation with reduced oxygen delivery to tissues farthest from the center of the body?", "Are there visible changes in the epidermis, dermis, or subcutaneous layer of the extremities?", "Can you see structures such as peripheral veins, peripheral arteries, or capillary networks connecting distal regions to the central circulatory system?", "Is there an area displaying bluish discoloration, cool temperature, or moist skin?", "Do the upper limbs, lower limbs, or distal extremities show any distinguishing features?", "Are there visible interactions between the affected regions and the nervous, endocrine, or musculoskeletal systems?"], "contexual_behavior": ["Does the image show any changes in the appearance of the extremities that could be influenced by exposure to cold temperatures?", "Is there evidence of peripheral features that might improve after warming or exposure to a warm environment?", "Can you identify any signs that could become more pronounced during emotional stress or sympathetic nervous system activation?", "Does the image suggest changes that might decrease in intensity following physical activity or increased circulation?", "Is there a visible feature that appears persistent, even after removal of an apparent trigger, possibly indicating an underlying vascular or systemic disease?", "Are there signs that could be more severe in the context of peripheral vascular disease or impaired blood flow?", "Does the image suggest reduced intensity of symptoms that might be expected in a warm climate?", "Can you see features that might be more persistent in individuals with connective tissue disorders or microvascular dysfunction?", "Is there evidence of changes that could worsen during hypotension or shock due to reduced perfusion?", "Does the image show features that might improve with enhanced cardiac output or increased peripheral blood flow?", "Are there signs that appear less responsive to temperature changes, possibly indicating a chronic condition?", "Can you identify features that could increase in frequency during anxiety or panic attacks due to sympathetic response?", "Is there evidence of improvement in symptoms that might follow successful treatment of an underlying endocrine disorder affecting vascular tone?", "Does the image suggest increased severity of findings in the presence of anemia or reduced oxygen-carrying capacity?", "Are there features that fail to improve after rewarming, possibly indicating arterial occlusion and persistent obstruction to blood flow?"], "functions": ["Does the image show persistent bluish discoloration and coolness of the skin, especially on the hands or feet?", "Can you identify signs of reduced blood flow in the small vessels of the extremities, such as color changes or coolness?", "Is there evidence of lower skin temperature in areas with visible discoloration, suggesting limited warm arterial blood supply?", "Do you observe any regions where impaired oxygen delivery to peripheral tissues is indicated by a bluish tint?", "Are there visual cues of constricted arterioles or sluggish capillary circulation in the skin of the extremities?", "Does the image show chronic coolness and discoloration in the hands or feet, suggesting decreased tissue perfusion?", "Can you see persistent cyanosis in superficial tissues that might indicate chronic hypoxia without obvious tissue damage?", "Is there evidence that the discoloration worsens in response to cold exposure or improves with warming?", "Do you observe features suggesting a protective response to cold, such as reduced heat loss through peripheral vasoconstriction?", "Are there signs of impaired capillary function, such as slowed blood flow or increased deoxygenated blood in the skin?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you identify an area where the protein content could be around 20 to 30 percent of its dry weight?", "Is there a region that might have a high collagen content, making up the majority of its dry weight?", "Is there a region where fibroblasts seem to make up the majority of the cellular population?"], "relational": ["Does the image show tissue that could be classified as loose or dense connective tissue?", "Does the image contain areas composed of cells such as fibroblasts, immune cells, endothelial cells, or adipocytes?", "Can you see structures that appear to provide support to organs like the breast, prostate, lung, or colon?"], "contexual_behavior": [], "functions": ["Can you see evidence of cytokine or chemokine release that could indicate regulation of inflammation or modulation of immune cell activity?", "Is there a visible area involved in remodeling the extracellular matrix or coordinating cellular responses for tissue regeneration?", "Can you see regions where immune cells are being recruited or where antigen presentation might be occurring within the tissue?"]}}}
[ { "answer": "spleen", "extracted_concepts": [ "spleen" ], "question": "what does this image show?" }, { "answer": "yes", "extracted_concepts": [ "thrombotic thrombocytopenic purpura", "spleen", "infarcts" ], "question": "does this image show spleen, infarcts, thrombotic thrombocytopenic purpura?" }, { "answer": "no", "extracted_concepts": [ "thrombotic thrombocytopenic purpura", "spleen", "anencephaly", "infarcts" ], "question": "does anencephaly show spleen, infarcts, thrombotic thrombocytopenic purpura?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" }, { "answer": "yes", "extracted_concepts": [ "hematologic" ], "question": "is hematologic present?" }, { "answer": "no", "extracted_concepts": [ "bone", "clivus" ], "question": "is bone, clivus present?" }, { "answer": "spleen", "extracted_concepts": [ "spleen" ], "question": "where is this part in?" }, { "answer": "hematologic", "extracted_concepts": [ "hematologic" ], "question": "what is present?" } ]	["spleen", "bone", "thrombotic thrombocytopenic purpura", "infarcts", "clivus", "hematologic", "anencephaly"]	{"spleen": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure in the image that measures between 11 and 14 centimeters in length?", "Can you identify an object that typically weighs around 150 to 200 grams in a healthy adult?", "Does the image show an ovoid or wedge-shaped anatomical structure?", "Is there a region with a deep purplish-red coloration visible?", "Can you see a structure that appears soft and friable in texture?", "Is there an object whose estimated volume is between 150 and 250 milliliters?", "Does the image contain a region likely to be composed of lymphocytes, macrophages, and reticular cells?", "Can you identify a structure that would be expected to have about 75% water content by weight?", "Is there an object that could contain iron at a concentration of 0.5 to 1.5 milligrams per gram of tissue?", "Does the image show a structure that would maintain a pH close to 7.4?", "Can you see an anatomical region with a density around 1.05 grams per cubic centimeter?", "Is there a structure that might contain approximately 18% protein and 2% lipid by wet weight?", "Can you identify an object whose temperature would match core body temperature, about 37 degrees Celsius?", "Does the image show a structure that lacks distinct lobules but may be divided into white and red pulp regions?", "Is there a region surrounded by a capsule and traversed by trabeculae, with connective tissue making up about 7% of its mass?", "Can you see a structure likely to contain enzymes such as acid phosphatase, catalase, and peroxidase?", "Is there an object in the image where the oxygen level is expected to be lower than arterial blood, around 40 mmHg?", "Does the image contain a region where the glucose concentration would be similar to venous blood, about 70 to 110 mg/dL?", "Can you identify a structure that could hold approximately 200 to 350 milliliters of blood?"], "relational": ["Does the image contain a structure that is part of the lymphatic system?", "Can you identify an organ located in the left upper quadrant of the abdominal cavity?", "Is there a structure situated near the stomach, left kidney, or pancreas?", "Does the image show an organ connected to the splenic artery or splenic vein?", "Can you see a structure supported by the splenorenal or gastrosplenic ligament?", "Is there evidence of tissues resembling white pulp or red pulp?", "Does the image contain an area rich in lymphocytes, macrophages, or dendritic cells?", "Can you identify a secondary lymphoid organ within the lymphatic system?", "Is there a structure associated with vascular channels such as sinusoids, but not directly with ducts?", "Does the image show an organ that interacts with lymph nodes, bone marrow, or thymus in immune responses?"], "contexual_behavior": [], "functions": ["Does the image show a structure responsible for filtering blood and removing aged or abnormal blood cells?", "Is there an organ present that participates in immune surveillance and initiates immune responses against blood-borne antigens?", "Can you identify a region in the image that contains both red pulp and white pulp?", "Does the image include a structure where lymphocytes are activated and immune responses are initiated?", "Is there evidence of phagocytic activity by macrophages in a particular region of the tissue?", "Can you see an area that serves as a reservoir for platelets or red blood cells?", "Is there a structure that facilitates the maturation and proliferation of lymphocytes within a specialized region?", "Does the image contain evidence of a site where pathogens are filtered from circulation and adaptive immunity is initiated?", "Can you identify a region involved in breaking down senescent red blood cells and recycling iron to the bone marrow?", "Is there a structure that provides an environment for B lymphocyte activation and differentiation into plasma cells?", "Does the image show an organ that regulates the balance of white blood cells and platelets by sequestering and releasing them as needed?", "Can you see evidence of increased lymphocyte proliferation and antibody synthesis in response to infection?", "Is there a region where cellular debris is removed from the blood by macrophages?"]}, "no_questions": {"contexual_properties": ["Is there infiltration by inflammatory cells, as might be seen in infection or autoimmune reactions?", "Is there a visible decrease in volume that could be attributed to tissue loss or chronic disease?", "Do you observe cystic spaces that could be associated with degenerative disease or congenital anomalies?"], "properties": ["Can you identify something that might have a neutral pH if tested?", "Can you identify an item that looks soft and porous, possibly made of cotton or similar materials?", "Does the image show an item that could retain and hold significant amounts of moisture?"], "relational": ["Can you see a region bounded anteriorly by the sternum and posteriorly by the vertebral column?", "Does the image display compartments such as the anterior, middle, posterior, or superior mediastinum?", "Can you identify an area that is adjacent to both the lungs and the heart?"], "contexual_behavior": ["Can you identify an object that might show reduced function in the setting of chronic disease or prolonged inflammation?", "Does the image show a region where activity appears diminished, possibly due to aging or decreased immune responsiveness?", "Does the image suggest a component responding to hormonal changes by altering its function?"], "functions": ["Is there evidence in the image of a structure or system that supports or regulates physiological functions?", "Is there an indication of dynamic processes like feedback loops, adaptation, or response to environmental changes?", "Is there a structure that appears to maintain equilibrium or adjust physiological parameters within the internal environment?"]}}, "bone": {"yes_questions": {"contexual_properties": ["Does the image contain a structure that provides support to the body?", "Can you see something that serves as an attachment point for muscles?", "Is there an object that might protect internal organs?", "Does the image show a structure that could be involved in movement or locomotion?", "Can you identify something with a hard or rigid appearance?"], "properties": [], "relational": ["Does the image show a structure that is part of the skeletal system?", "Can you identify something that contains osseous tissue or bone marrow?", "Is there a structure present that is covered by periosteum or endosteum?", "Can you see evidence of cells such as osteoblasts or osteocytes within a structure?", "Does the image include objects that are connected by ligaments?", "Is there a structure that provides support or protection to organs like the brain or spinal cord?", "Can you identify connective tissue that may be covered by articular cartilage at a joint?", "Is there a region in the head, trunk, or limbs that contains a hard, supportive structure?", "Does the image show muscles attaching to a structure via tendons?", "Can you see a cavity or space within a structure that could house bone marrow?", "Is there a visible area where hematopoiesis might occur?", "Does the image show an articulation, such as a synovial or fibrous joint, where two or more hard structures meet?"], "contexual_behavior": [], "functions": ["Does the image show a structure that provides the rigid framework supporting soft tissues and maintaining body shape?", "Can you identify an object that enables movement by acting as a lever in conjunction with muscles?", "Is there a structure visible that encases or shields vital organs such as the brain, heart, or lungs?", "Does the image contain something that serves as a reservoir for minerals like calcium and phosphate?", "Can you see a structure that might regulate calcium levels in the body in response to hormonal signals?", "Is there an object present that produces blood cells within its red marrow?", "Does the image show a structure that stores energy in the form of lipids within yellow marrow?", "Can you identify something that contributes to phosphate homeostasis by storing and releasing phosphate ions?", "Is there a structure that helps maintain acid-base balance through mineral exchange?", "Does the image contain an object that interacts with hormones such as growth hormone or sex steroids to regulate growth and development?", "Can you see evidence of a structure undergoing continuous repair or remodeling through the activity of specialized cells like osteoblasts and osteoclasts?", "Is there a visible structure that supports immune defense by housing hematopoietic stem cells within its marrow?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image suggest possible direct extension of a mass into organs like the bladder, small intestine, or abdominal wall?", "Does the image reveal involvement of lymph nodes such as mesenteric, paracolic, or pericolic nodes near a colonic region?", "Does the image show a malignant process affecting the gastrointestinal system?"], "contexual_behavior": [], "functions": ["Can you see evidence of immune cell infiltration or regions where immune surveillance might be evaded?", "Is there any indication of cells spreading beyond their original location, suggesting metastatic potential or epithelial-mesenchymal transition?", "Is there visible damage to the mucosal surface that could impair nutrient absorption?"]}}, "thrombotic thrombocytopenic purpura": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show evidence of a disorder affecting the hematologic, nervous, or renal systems?", "Can you identify changes in vascular endothelium, blood, or renal tissue?", "Is there a visible alteration in blood components such as platelets or red blood cells?", "Does the image suggest involvement of von Willebrand factor in the pathology?", "Are there signs of damage or abnormality in organs like the kidneys, brain, or heart?", "Can you see abnormalities in small blood vessels such as arterioles, capillaries, or small venules?", "Is there evidence of widespread microvascular thrombosis in the microvasculature?", "Does the image show cells like platelets, endothelial cells, or red blood cells involved in a pathological process?", "Are there indications of injury to the kidneys, central nervous system, or heart?", "Can you detect features consistent with thrombocytopenia or hemolytic anemia?", "Does the image suggest the presence of a thrombotic microangiopathy or another hematologic disorder?", "Is there visual evidence pointing toward an autoimmune disease affecting the microvasculature?"], "contexual_behavior": [], "functions": []}, "no_questions": {"contexual_properties": ["Is there visual evidence of cells changing in size or shape, possibly indicating activation or differentiation in response to liver damage?", "Is there evidence of cytoskeletal reorganization in cells that might be migrating or differentiating?", "Can you identify small cells that appear more numerous in regions where hepatocyte proliferation might be impaired?"], "properties": ["Is there a basophilic cell visible, appearing blue to purple with standard stains under the microscope?", "Can you identify a cell where water constitutes about 70 to 80% of its total mass?", "Does the image show a cell with a high nuclear-to-cytoplasmic ratio, around 0.7 to 0.8?"], "relational": ["Are there cells near branches of the portal vein or hepatic artery?", "Does the image contain cells found within the canals of Hering or periportal areas?", "Is there evidence of cells that could give rise to hepatocytes during liver regeneration or injury?"], "contexual_behavior": ["Does the image show increased differentiation into bile duct cells as a response to cholestasis or ductular reaction?", "Does the image indicate enhanced function of a progenitor cell type during acute liver failure to compensate for massive cell loss?", "Does the image suggest increased activity of a progenitor population in response to metabolic stress, such as steatosis or insulin resistance?"], "functions": ["Can you see cells that help maintain tissue homeostasis by providing new cells during periods of cellular turnover or mild injury?", "Is there a visible expansion or activation of cells in response to chronic liver damage?", "Can you identify cells that are integrating into the liver parenchyma as replacements for damaged hepatocytes?"]}}, "infarcts": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a region in the image that appears wedge-shaped or triangular, suggesting a pattern related to vascular supply?", "Can you identify an area that is pale, white, or dark red, possibly indicating different types of tissue injury?", "Does the image show a structure with a soft or friable texture that might become firmer or fibrotic over time?", "Is there a zone with decreased tissue density compared to the surrounding area?", "Can you see a well-demarcated border separating two regions, possibly with an adjacent zone of inflammation?", "Is there evidence of hemorrhage in a localized area, or is the region notably pale, suggesting different types of tissue injury?", "Does the image contain an area that could be measured in centimeters and varies in size from a few millimeters to several centimeters?", "Can you identify a region that might have high water content or edema, especially in the early stages of tissue injury?", "Is there a visible area that could contain necrotic tissue, cellular debris, or inflammatory cells such as neutrophils or macrophages?", "Does the image show a region that could be classified as acute, subacute, or chronic based on its appearance or stage of healing?", "Is there a granular or friable texture present in any part of the tissue, possibly progressing to a more fibrotic appearance?", "Can you see a region that might have low oxygen or appear hypoxic due to loss of blood supply?"], "relational": ["Does the image show evidence of tissue disruption or loss of normal architecture in regions such as the myocardium or brain tissue?", "Can you identify areas within the heart, brain, kidneys, lungs, or spleen that appear abnormal compared to surrounding tissue?", "Is there a region in the image where arteries or arterioles may be implicated in a pathological process?", "Does the image display changes in the cerebral cortex, myocardial wall, renal cortex, or pulmonary lobes that suggest localized damage?", "Can you see areas characterized by necrosis or loss of function within any tissue?", "Is there visual evidence of involvement of the cardiovascular, nervous, renal, or respiratory systems in a pathological process?", "Are there regions containing cells such as neutrophils or macrophages, possibly indicating an inflammatory response?", "Can you identify boundaries between damaged and viable tissue, or the presence of an inflammatory infiltrate or fibrous capsule?", "Does the image show signs of edema, inflammation, reactive gliosis, or fibrosis adjacent to an area of tissue damage?", "Is there visual evidence of a process such as ischemia, thrombosis, or embolism affecting the tissue?"], "contexual_behavior": [], "functions": ["Does the image show an area where tissue appears non-viable, suggesting loss of function in an organ?", "Is there evidence of localized cell death due to a prolonged lack of oxygen and nutrients?", "Can you identify a region with significantly reduced or absent blood supply, possibly indicating vascular occlusion?", "Does the image contain tissue that appears to have been replaced by non-functional scar tissue?", "Is there a visible area where normal biological processes such as oxygen delivery or nutrient exchange might be impaired?", "Can you see signs of compromised cellular metabolism, such as regions that might be experiencing hypoxia?", "Is there evidence of an inflammatory response, such as immune cell infiltration, near a damaged tissue area?", "Does the image show features consistent with tissue repair mechanisms, like phagocytosis of dead cells or scar formation?", "Is there a region in the brain where disruption of neural signaling could lead to neurological deficits?", "Can you identify an area in cardiac tissue where electrical conduction or contractility might be impaired?", "Does the image show a region with signs of irreversible cell injury or necrosis?", "Is there evidence of impaired tissue perfusion that could negatively affect the circulatory system or increase the risk of thrombosis?"]}, "no_questions": {"contexual_properties": ["Is there a detectable change in head circumference that might be identified by prenatal imaging due to partially fused heads?", "Does the image reveal altered bone density in the skull, possibly resulting from abnormal bone formation and fusion during embryonic development?", "Can you identify abnormal cranial structures that might result from incomplete cranial division in the prenatal period?"], "properties": ["Are there four ears present, with two ears per face?", "Is there a broad and rounded cranial shape suggestive of bifacial cranium or cranial widening?", "Does the length of the newborn appear within the typical range of 45 to 55 centimeters?"], "relational": ["Does the image show a single head with two complete faces oriented in opposite directions?", "Can you identify a structure where the cranium is fused but facial features such as eyes, noses, and mouths are duplicated?", "Can you see a region where the frontal, temporal, or occipital areas of the head appear structurally altered due to facial duplication?"], "contexual_behavior": ["Can you identify signs of altered breathing patterns that could result from shared thoracic structures or malformed thoracic organs?", "Does the image depict abnormal feeding behavior, possibly due to both mouths attempting to feed at the same time or interference between oral structures?", "Does the image show an individual with two heads that might have difficulty coordinating movement or integrating sensory information?"], "functions": ["Does the image reveal abnormalities that could disrupt normal physiological processes in the head or brain?", "Does the image show a developmental anomaly characterized by craniofacial duplication?", "Can you identify evidence of conjoined twinning involving two faces on a single head?"]}}, "clivus": {"yes_questions": {"contexual_properties": [], "properties": ["Is there a structure present that measures approximately 4 to 6 centimeters in length?", "Can you identify a region with a width of about 2 to 3 centimeters at its broadest point?", "Does the image show a bony area with a thickness of roughly 1 to 1.5 centimeters?", "Is there a sloping, concave bone visible in the cranial base?", "Can you see a structure whose bone density appears similar to other bones at the base of the skull, typically around 1.2 to 1.5 g/cm\u00b3?", "Is there an obliquely oriented bone running downward and backward from the dorsum sellae toward the foramen magnum?", "Does the image contain a structure forming an angle of about 120 to 135 degrees with the skull base?", "Can you identify a region composed of both cortical and cancellous bone tissue?", "Is there a bony surface that appears generally smooth?", "Can you see a bone with a pale yellow to light brown coloration, as seen in fresh specimens?", "Is there a structure with an estimated volume of 8 to 12 cubic centimeters?", "Does the image show a bone whose mineral content is primarily hydroxyapatite and calcium phosphate?", "Can you identify a gently curved bone with an anterior concavity?", "Is there evidence of a bone formed by endochondral ossification from the basioccipital and basisphenoid regions?", "Does the image show a cranial base structure that would typically complete fusion by late adolescence, around age 18?"], "relational": ["Does the image show a structure that is part of the cranial base?", "Can you identify a region that is adjacent to both the sphenoid bone and the occipital bone?", "Is there an area associated with the posterior cranial fossa?", "Can you see a structure that is centrally located at the base of the skull?", "Is there a region situated anterior to the foramen magnum and brainstem?", "Does the image include an area that is posterior to the sphenoid sinus and dorsum sellae?", "Can you identify a location near the hypoglossal canal or jugular foramen?", "Is there a structure closely related to the pons or medulla oblongata?", "Does the image show proximity to vascular structures such as the basilar artery or inferior petrosal sinus?", "Can you see a region that forms the posterior part of the sphenoid bone and the anterior part of the occipital bone, articulating with both?"], "contexual_behavior": ["Does the image show evidence of bone erosion or thinning at the cranial base that could reduce support for the brainstem?", "Can you identify any signs of instability or fracture at the base of the skull that might result from trauma?", "Is there visual evidence of bone destruction or displacement of tissues near neurovascular structures that could suggest tumor invasion?", "Does the image reveal decreased bone density or deformation in a cranial base structure that might indicate osteoporosis?", "Can you see any anatomical alterations or reduced stability in the cranial base region that could result from surgical resection?", "Is there any indication of compromised separation between the brain and nasopharynx, such as bone loss or abscess formation, that might suggest infection?", "Does the image display features consistent with congenital malformations like basilar invagination or hypoplasia affecting cranial base integrity?", "Can you observe deformation or displacement of a cranial base structure that could be related to increased intracranial pressure?", "Is there evidence of bone swelling or erosion at the cranial base that might be due to inflammatory conditions such as osteitis or granulomatous disease?", "Does the image show weakening of bone or displacement of adjacent neural structures in the cranial base region that could be caused by metastatic lesions?"], "functions": ["Does the image show a sloping bony surface that supports the brainstem?", "Can you identify a structure that contributes to the structural integrity of the cranial base?", "Is there a bony platform that prevents downward displacement of the brainstem?", "Does the image contain a feature that shields the pons and medulla oblongata from mechanical injury?", "Can you see a structure that connects the sphenoid and occipital bones, reinforcing the central skull base?", "Is there a midline element that helps maintain alignment between anterior and posterior cranial structures?", "Does the image show a region that forms part of the pathway for arteries, veins, or cranial nerves at the skull base?", "Can you identify a structure that separates the posterior cranial fossa from the upper cervical spinal canal, thereby demarcating neural compartments?"]}, "no_questions": {"contexual_properties": ["Are there vessels where the normal vascular components seem to be replaced by other material?", "Can you see signs of vessel stiffening or rigidity that might result from infiltration of non-native proteins?", "Do any vessels appear to have increased permeability or signs of endothelial dysfunction?"], "properties": [], "relational": ["Can you identify abnormalities involving small- to medium-sized blood vessels, such as cerebral arteries or arterioles?", "Does the image suggest features consistent with cerebral small vessel disease or neurodegeneration?", "Is there visible involvement of the cerebral cortex or leptomeninges?"], "contexual_behavior": [], "functions": ["Is there visual evidence of amyloid deposition within cerebral vessels?", "Does the image show evidence of vascular dysfunction in the brain, such as impaired vessel integrity or signs of hemorrhage?", "Is there evidence of smooth muscle cell loss or abnormal accumulation within the tunica media or adventitia of vessels?"]}}, "hematologic": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image contain a sample composed of red blood cells, white blood cells, platelets, and plasma?", "Can you identify a specimen that typically appears red in color?", "Is there evidence of a fluid with a viscosity between 3 and 4 centipoise at 37\u00b0C?", "Does the image show a sample whose pH would be expected to fall between 7.35 and 7.45?", "Can you see a sample that might have a density around 1.050 to 1.060 g/mL?", "Is there a specimen that would normally be collected in a volume between 2 and 10 mL for analysis?", "Does the image include a sample that could be assessed for hemoglobin concentration in the range of 12.0\u201317.5 g/dL depending on sex?", "Can you identify a sample where the hematocrit value might be between 36% and 53%?", "Is there a structure that would be expected to have a red blood cell count within the typical range for males or females?", "Does the image show a specimen that could be evaluated for a white blood cell count between 4,000 and 11,000 cells/\u03bcL?", "Can you see a sample that would be expected to contain 150,000 to 450,000 platelets per microliter?", "Is there a sample present that could have a mean corpuscular volume (MCV) between 80 and 100 fL?", "Does the image include a specimen where the mean corpuscular hemoglobin concentration (MCHC) might be 32\u201336 g/dL?", "Can you identify a sample that could have a mean corpuscular hemoglobin (MCH) of 27\u201333 pg/cell?", "Is there a specimen that would be expected to have an iron level between 60 and 170 \u03bcg/dL?", "Does the image show a sample that could have a fasting glucose concentration of 70\u201399 mg/dL?", "Can you see a specimen with a protein content typically between 6 and 8 g/dL?", "Is there a sample that would be expected to have a sodium concentration of 135\u2013145 mmol/L?", "Does the image include a specimen where the potassium concentration might be 3.5\u20135.0 mmol/L?", "Can you identify a sample that could have a calcium concentration between 8.5 and 10.5 mg/dL?"], "relational": ["Does the image show any structures that are part of the circulatory or immune systems?", "Can you identify an organ such as the bone marrow, spleen, or thymus?", "Is there evidence of hematopoietic or lymphoid tissue present?", "Does the image contain cells like red blood cells, white blood cells, or platelets?", "Are there visible blood vessels, lymph nodes, or the heart in the image?", "Can you see anatomical features that participate in immunity, fluid balance, or cell production?", "Is there a body fluid such as blood, plasma, or serum depicted?", "Does the image include regions like the bone marrow, spleen, lymph nodes, or bloodstream?", "Are arteries, veins, or capillaries visible in the image?", "Can you identify organs that contribute to the formation of blood components, such as the bone marrow, liver, or spleen?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a process responsible for transporting oxygen in the body?", "Can you identify structures or cells involved in immune defense, such as those producing antibodies or performing phagocytosis?", "Is there visual indication of mechanisms that facilitate blood clotting, like platelet activation or fibrin formation?", "Does the image include features related to the production of blood cells, such as hematopoiesis occurring in bone marrow?", "Can you see evidence of waste removal from the blood, such as the transport of metabolic byproducts or carbon dioxide?", "Is there a visible indication of processes that help maintain pH balance, possibly through buffering by plasma proteins or hemoglobin?", "Does the image show a response to infection or injury, such as activation of leukocytes or the presence of inflammatory mediators?", "Can you identify features related to the regulation of bleeding, such as vasoconstriction or platelet plug formation?", "Is there evidence of nutrient transport in the bloodstream, such as the movement of glucose, amino acids, or lipids?", "Does the image display signs of inflammation, like the mobilization of leukocytes or acute phase proteins?", "Can you observe features that suggest maintenance of blood volume, such as regulation by plasma proteins or erythrocyte mass?", "Is there visual evidence of the removal of old or damaged blood cells, such as phagocytosis by macrophages in organs like the spleen or liver?"]}, "no_questions": {"contexual_properties": ["Is there visible bruising that could result from blunt force, a fall, or a coagulopathy?", "Can you identify any areas of discoloration that might indicate bruising, cyanosis, or jaundice?", "Are there abnormal surface features such as lesions, ulcers, or congenital malformations present?"], "properties": ["Can you observe differentiation between soft tissue, bone, and air spaces, indicating appropriate contrast levels in the image?", "Does the image display a region with an oval or rounded shape that matches the typical contours of the human head?", "Does the image appear to be captured in the axial plane, as is standard for this type of view?"], "relational": ["Does the image contain organs such as the brain, eyes, or oral cavity?", "Is there a visible feature corresponding to the orbicularis oculi or orbicularis oris?", "Are tissues such as bone, muscle, or nervous tissue observable in the depicted area?"], "contexual_behavior": ["Does the image show a situation where sensory input might be reduced due to visual impairment such as cataracts or retinal disease?", "Is there a sign of altered awareness of one side of space, possibly indicating spatial neglect syndrome?", "Does the image include features that might indicate impaired vision following traumatic injury to the brain, eyes, or cranial nerves?"], "functions": ["Are there any abnormal contours, asymmetry, or visible lumps suggesting soft tissue swelling or masses?", "Can you identify any anatomical structures in the head region that would be relevant for clinical evaluation?", "Is there visible asymmetry when comparing bilateral facial features?"]}}, "anencephaly": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show an individual with a markedly reduced cranial size compared to normal?", "Is there evidence of microcephaly or a head circumference far below the expected range for gestational age?", "Can you identify a case where the cranial vault appears absent or severely underdeveloped, potentially exposing underlying tissue?", "Is there visible neural tissue that appears dark red to purple and has a friable, gelatinous texture?", "Does the image reveal disorganized or incomplete remnants of forebrain and midbrain structures?", "Can you see exposed neural tissue with a disorganized appearance and absence of the cerebrum?", "Is there a near-complete absence of skull bones in the cranial region?", "Does the brain tissue volume appear severely diminished, possibly limited to rudimentary brainstem structures?", "Is there evidence of malformed brainstem or primitive neural elements with no visible cerebral hemispheres?", "Can you infer from the image that the brain weight would likely be significantly below normal, possibly less than 100 grams?"], "relational": ["Does the image show absence or severe malformation of major structures such as the cerebral hemispheres or cranial vault?", "Is there a region of the head where the scalp appears missing or abnormal?", "Can you identify abnormalities affecting the forebrain or midbrain regions?", "Does the image reveal missing parts of the brain such as the cerebral cortex or cerebrum?", "Is there evidence of absent or malformed diencephalon in the cranial area?", "Are the bones of the skull or meninges visibly absent or disrupted?", "Can you see areas where neural tissue is exposed or not covered by cranial bone or skin?", "Is there a failure of cranial bone or overlying ectoderm development visible in the image?", "Does the image suggest a disruption in neural tube closure, particularly at the anterior end?", "Are there visible abnormalities in both the nervous and integumentary systems of the head?", "Can you identify regions where embryological structures such as the neural plate or neural folds may have failed to develop properly?", "Is the interface between the brain and skull altered, with evidence of exposed neural tissue?", "Does the upper facial region or calvaria appear structurally abnormal or incomplete?", "Is there a lack of normal scalp covering the cranial region?", "Are the skull bones missing or severely underdeveloped in the cranial area?"], "contexual_behavior": ["Does the image show evidence of a neural tube defect affecting the development of brain structures during early embryogenesis?", "Can you identify a fetus with malformation or absence of major brain regions that would disrupt central autonomic control?", "Is there a visible absence or severe underdevelopment of the forebrain and cerebrum, suggesting reduced neural control of vital physiological processes?", "Does the image indicate impaired coordination of fetal movement due to missing or underdeveloped motor cortex and neural circuits?", "Can you observe signs of failed sensory processing in the fetus, possibly due to missing sensory relay centers in the brain?", "Is there evidence of disrupted signaling between the brain and other organs, as might occur if neural pathways for inter-organ communication are absent?", "Does the image suggest abnormal regulation of heart rate or respiration that could result from a malformed or absent brainstem?", "Can you see indications that hypothalamic or pituitary structures have failed to develop, potentially affecting neurohormone production?", "Is there a decreased capacity for reflex responses in the fetus, possibly due to incomplete or absent neural circuits in the brain?", "Does the image show a lack of integration of neural pathways necessary for survival after birth, as would be expected if critical brain regions are missing?"], "functions": ["Does the image show an individual with severe malformation of the brain, particularly lacking the cerebral hemispheres and forebrain?", "Can you identify a case where neural regulation of vital physiological processes such as breathing and heart rate appears critically compromised?", "Is there evidence of profound sensory and motor deficits due to missing essential brain structures?", "Does the image suggest inadequate regulation of involuntary functions like blood pressure or digestion, indicating autonomic instability?", "Can you observe signs of impaired respiratory or cardiovascular regulation, such as respiratory failure or abnormal heart function?", "Is there an absence of normal reflexes or basic survival behaviors, possibly due to missing neural circuits in the brainstem or higher centers?", "Does the image indicate disruption of hormonal regulation or homeostasis, such as impaired hypothalamic or pituitary function?", "Can you see evidence of abolished movement coordination or postural instability, potentially due to absent cerebrum and cerebellum?", "Is there a complete lack of consciousness or cognitive function, as might be expected if the cerebral cortex is not developed?", "Does the image suggest a loss of communication between organ systems, possibly due to missing central neural pathways?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image contain evidence of chromatin structure?", "Can you identify a cellular region where higher-order chromatin fibers might be observed?", "Can you identify a region where protein complexes such as histone octamers might be assembled?"], "contexual_behavior": [], "functions": ["Is there evidence of elements that control chromatin condensation during the cell cycle?", "Does the image display features related to the assembly of nucleosomes?", "Can you see any indication of structures that undergo chemical modifications such as methylation or acetylation to regulate gene activity?"]}}}

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