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[
{
"answer": "in the canals of hering",
"extracted_concepts": [
"oval cells",
"liver stem cells",
"canals of hering"
],
"question": "where are liver stem cells (oval cells) located?"
},
{
"answer": "bile duct cells and canals of hering",
"extracted_concepts": [
"immunohistochemical stain for cytokeratin 7",
"bile duct cells",
"canals of hering"
],
"question": "what are stained here with an immunohistochemical stain for cytokeratin 7?"
},
{
"answer": "an immunohistochemical stain",
"extracted_concepts": [
"bile duct cells",
"cytokeratin 7",
"immunohistochemical stain",
"canals of hering"
],
"question": "what are bile duct cells and canals of hering stained here with for cytokeratin 7?"
},
{
"answer": "yes",
"extracted_concepts": [
"bile duct cells",
"cytokeratin 7",
"immunohistochemical stain",
"canals of hering"
],
"question": "are bile duct cells and canals of hering stained here with an immunohistochemical stain for cytokeratin 7?"
}
] |
["immunohistochemical stain for cytokeratin 7", "cytokeratin 7", "bile duct cells", "immunohistochemical stain", "liver stem cells", "oval cells", "canals of hering"]
|
{"immunohistochemical stain for cytokeratin 7": {"yes_questions": {"contexual_properties": ["Does the image show areas with increased staining intensity in regions that could correspond to carcinomas or reactive epithelial cells?", "Are there regions in the image where staining is absent in structures that might represent hepatocytes, colorectal carcinoma, or squamous epithelium?", "Can you identify patchy staining patterns that could indicate heterogeneous tumors, such as ovarian or endometrial cancers?", "Is there reduced staining intensity in areas that may correspond to poorly differentiated tumors or regions with low protein expression?", "Does the image display diffuse staining in regions that could represent uniformly expressing tissues, such as lung or breast adenocarcinoma?", "Are there focal staining patterns that might be associated with tumors like urothelial carcinoma?", "Can you observe cytoplasmic localization of the stain in epithelial cells, consistent with intermediate filament proteins?", "Is there evidence of membranous staining that could be attributed to fixation artifacts or specific tumor subtypes?", "Do any tumor regions show more prominent staining, suggesting a CK7-positive origin such as cholangiocarcinoma or serous carcinoma?", "Are there areas where staining is lost, possibly indicating dedifferentiation or epithelial-mesenchymal transition?", "Can you detect aberrant staining patterns that might be due to neoplastic transformation, genetic mutations, or technical artifacts?", "Is there increased staining intensity in inflamed tissue, suggesting upregulation in reactive epithelial cells?", "Does the image reveal heterogeneous staining in tumors with mixed cell populations or variable protein expression?", "Are there granular staining patterns that could be due to cytoplasmic aggregation or specific fixation conditions?", "Is there increased background staining that might result from inadequate blocking, high antibody concentration, or poor tissue processing?", "Do necrotic areas show weaker staining, possibly due to protein degradation and loss of antigenicity?", "Is there any nuclear staining present, which could indicate a technical artifact rather than true protein localization?", "Are there regions of more intense staining in regenerative tissue where epithelial proliferation may be occurring?", "Can you observe altered distribution of staining in areas that might correspond to dysplastic or neoplastic tissue?", "Is staining more prominent at the invasive front of a tumor, suggesting active invasion by epithelial cells?"], "properties": ["Does the image show cells with a brown coloration indicating a positive reaction to a specific chromogen?", "Can you identify a staining pattern that is cytoplasmic, possibly with membranous accentuation, in epithelial cells?", "Is there evidence of a highly sensitive method for detecting epithelial cells expressing a particular intermediate filament protein?", "Does the image display a staining result that is highly specific for a protein with a molecular weight of approximately 54 kilodaltons?", "Can you observe a chromogenic reaction that is likely due to the use of 3,3'-diaminobenzidine (DAB)?", "Is there visual evidence suggesting the use of an antibody of the IgG isotype in the staining protocol?", "Does the staining pattern suggest that the optimal antibody dilution was within the range of 1:50 to 1:200?", "Can you infer that the incubation time for the staining procedure was between 30 and 60 minutes at room temperature based on the staining intensity and pattern?", "Is there any indication that the buffer pH used during the staining process was between 6.0 and 7.0?", "Does the image suggest that heat-induced epitope retrieval with citrate buffer was performed prior to staining?", "Can you deduce that the staining reagent was likely stored at 2\u20138\u00b0C to maintain its effectiveness?", "Is there evidence that the reagent used in the staining process has a shelf life of 12 to 24 months when properly stored?", "Does the staining intensity suggest a detection limit in the low nanogram per milliliter range for the target protein?"], "relational": ["Does the image show a staining pattern that could be used to analyze tissues such as the lung, breast, or ovary?", "Is there evidence of a stain highlighting simple, glandular, or transitional epithelial cells?", "Can you identify regions where ductal, glandular, or transitional epithelium is marked by a specific stain?", "Does the image contain structures from organs commonly associated with cytoskeletal protein expression, such as the pancreas or biliary tract?", "Is there a staining pattern that helps detect or characterize epithelial tissues based on their cytoskeletal proteins?", "Can you see areas where the staining could be compared to other cytokeratin stains, such as cytokeratin 20 or cytokeratin 8?", "Does the image include cells from the respiratory, female genital, urinary, or gastrointestinal tracts that are highlighted by a particular stain?", "Are there epithelial layers, glandular structures, or ductal regions that are distinctly marked in the image?", "Can you assess cellular localization, staining intensity, or distribution pattern in the stained tissue?", "Is there evidence of a cytoskeletal protein from the intermediate filament family being visualized in epithelial cells?"], "contexual_behavior": ["Does the image show increased staining intensity in tumor regions that could originate from epithelial cells of the lung or breast?", "Is there evidence of reduced detection of epithelial cells in areas with chronic inflammation or apparent epithelial loss?", "Can you identify regions of a carcinoma with diminished staining, suggesting a loss of epithelial differentiation?", "Does the staining pattern appear altered in areas that might represent metastatic cancer, possibly indicating phenotypic adaptation?", "Is there evidence that combining this stain with other markers, such as CK20 or TTF-1, could help distinguish between primary and metastatic tumors in the image?", "Are there regions of necrotic tissue where the staining appears less sensitive or diminished, possibly due to antigen loss?", "Do areas showing squamous cell differentiation exhibit decreased positivity with this stain?", "Is there enhanced detection of ductal epithelial cells in regions that appear to be undergoing tissue regeneration?", "Does the staining fail to clearly differentiate between benign and malignant lesions in areas that might be affected by hypoxia?", "Are there regions with increased background staining, possibly due to inflammation or nonspecific binding?", "Can you observe any alteration in staining patterns that might be attributed to differences in tissue fixation methods?", "Is there reduced detection of epithelial cells in areas with extensive fibrosis, suggesting limited antibody penetration?", "Does the staining pattern support a diagnosis of cholangiocarcinoma over hepatocellular carcinoma by showing strong positivity in cholangiocyte-rich regions?", "Are there areas where staining is impaired, possibly due to autolytic changes and antigen degradation?", "Do you see enhanced staining in tissues that might have been exposed to chemotherapeutic agents, indicating upregulation of the target antigen?"], "functions": ["Does the image show evidence of a technique used to detect a specific protein within tissue samples?", "Can you identify areas where certain cells are highlighted due to the expression of a particular cytoskeletal protein?", "Is there a staining pattern that could help differentiate between various epithelial tissues?", "Does the image provide visual cues that could assist in identifying the origin of a tumor based on protein expression?", "Can you see features that might be used to distinguish between different tumor subtypes according to their biomarker status?", "Is there evidence of a method that supports the identification of metastatic tumors by revealing positive staining in secondary sites?", "Does the image contain information that could be used to monitor changes in protein expression during tumor development?", "Can you observe staining that would be relevant for guiding treatment decisions based on diagnostic findings?", "Is there a pattern present that could assist in evaluating the lineage or differentiation status of epithelial cells?", "Does the image provide visual information that could be used for functional characterization of tumors through assessment of a specific protein marker?"]}, "no_questions": {"contexual_properties": [], "properties": ["Does the image contain a structure with a density close to 1.05 grams per cubic centimeter?", "Does the image show an object with a smooth surface and fine transverse striations?", "Does the image show an object that might have a protein content of 10 to 20 percent of its dry weight?"], "relational": ["Does the image show an organism encountering barriers such as gastric acid, intestinal mucus, or the anal sphincter?", "Is there a structure associated with the large intestine or anus in the image?", "Can you see signs of egg deposition or irritation in the perianal area?"], "contexual_behavior": ["Is there an organism present that cannot complete its life cycle in non-human hosts due to host specificity?", "Is there an organism that increases its nocturnal activity to deposit eggs on the perianal skin, emerging at night in sync with the host's circadian rhythm?", "Does the image show an organism that increases its reproductive activity when its human host is asleep at night?"], "functions": ["Is there visual evidence of rapid reproduction or multiple life stages of a parasite within the intestinal lumen?", "Is there evidence of an organism colonizing the colon or rectum in the image?", "Is there a structure that could be responsible for gastrointestinal symptoms such as abdominal discomfort?"]}}, "cytokeratin 7": {"yes_questions": {"contexual_properties": ["Is there a region in the image where epithelial cell proliferation or tissue regeneration is suggested by increased staining intensity?", "Can you identify areas where staining is more pronounced in association with carcinoma, such as lung or breast cancer?", "Does the image show weaker staining in regions undergoing squamous differentiation or in poorly differentiated tumors?", "Are there areas with overexpression of a marker typically seen in adenocarcinomas, cholangiocarcinomas, or ovarian cancers?", "Can you observe more intense staining in hyperplastic epithelial lesions or in malignant tumors?", "Is there evidence of weaker staining in regions showing loss of epithelial features or advanced tumor dedifferentiation?", "Do you see changes in the distribution of a cytoskeletal protein in cells undergoing epithelial-mesenchymal transition or experiencing cellular stress?", "Is there abnormal localization of a cytoskeletal component in areas of neoplastic transformation or cytoskeletal disruption?", "Can you detect fragmented staining patterns in regions where apoptosis or proteolytic cleavage by caspases might be occurring?", "Are there areas where the molecular weight of a stained protein appears altered, possibly due to post-translational modifications or mutations?", "Is there a complete absence of staining in tissues lacking simple epithelial cells or in regions where expression is lost in certain cancers?", "Do you see cytoplasmic accumulation of a protein in areas with impaired protein degradation or cellular stress?", "Are there regions showing unexpected staining in tissues where this marker is normally absent, as might occur in metaplasia or metastatic tumors?", "Can you identify changes in isoform composition of a stained protein, potentially due to alternative splicing or disease-associated mutations?", "Is there evidence of increased glycosylation of a cytoskeletal protein in cancerous or stressed cells?", "Do you observe abnormal aggregation of a protein in regions affected by protein misfolding disorders or oxidative stress?"], "properties": ["Does the image show a brown staining pattern in epithelial cells that could indicate the presence of a protein encoded by a gene located on chromosome 12q13.13?", "Is there evidence of a cytoplasmic or perinuclear localization of a protein typically expressed at moderate to high levels in simple or glandular epithelial cells?", "Can you identify a structure that might contain a type II keratin with an alpha-helical coiled-coil domain?", "Does the image display staining consistent with a protein that is generally insoluble in physiological buffers but can be solubilized with detergents?", "Is there a visible marker that could correspond to a protein with a molecular weight of approximately 51 kilodaltons?", "Can you see staining that may represent a protein with a length of 469 amino acids?", "Does the image suggest the presence of a protein that is subject to post-translational modifications such as phosphorylation or glycosylation?", "Is there a feature in the image that could be explained by the presence of a protein with a normal half-life of several days in cells?", "Does the staining pattern suggest a protein with an isoelectric point around 5.2?", "Can you identify a structure that would be present in the cytoplasm, particularly around the nucleus, of epithelial cells?", "Is there evidence of a protein that is typically found in low micromolar concentrations in human epithelial tissues?", "Does the image show a pattern consistent with a protein whose secondary structure is predominantly alpha helix with some random coil regions?"], "relational": ["Does the image show epithelial cells that could be identified by the presence of intermediate filaments within their cytoplasm?", "Can you find glandular or ductal epithelial structures that might be positive for a cytoskeletal marker commonly found in the lung, breast, or ovary?", "Is there evidence of transitional or glandular epithelium in regions such as the respiratory tract or female genital tract?", "Does the image contain anatomical features like bile ducts or urothelium that are typically identified using specific epithelial markers?", "Are there epithelial cells present that might co-express cytoskeletal proteins used in diagnostic panels for distinguishing glandular tumors?", "Can you identify areas of tissue that are likely to express intermediate filament proteins from the cytokeratin family?", "Is there a visible epithelial layer in the urinary tract or endometrium that could be positive for a marker not found in stratified squamous or gastrointestinal epithelium?", "Does the image show any glandular tumors or ductal structures that could be highlighted by a cytoskeletal network marker?", "Are there regions where epithelial cells are present but are unlikely to express this marker, such as stratified squamous epithelium or hepatocytes?"], "contexual_behavior": [], "functions": ["Does the image show epithelial cells with evidence of a structural protein providing mechanical support?", "Can you identify a filamentous network within the cytoplasm that reinforces the cytoskeleton of epithelial cells?", "Is there a visible feature suggesting the maintenance of cell shape and stability through a resilient filament network?", "Does the image contain cells that could be distinguished by a marker indicative of specific epithelial lineages or differentiation states?", "Can you see evidence of tissue repair, such as cell migration or re-epithelialization, in epithelial tissue?", "Is there a structure that might be involved in modulating cell signaling pathways within epithelial cells?", "Does the image show features consistent with protection from mechanical stress, such as force distribution across the cytoskeleton?", "Can you observe intermediate filaments anchoring organelles and maintaining cellular architecture in epithelial cells?", "Is there evidence of regulation of cell proliferation or maintenance of epithelial homeostasis in the image?", "Does the image display signs of cytoskeletal reorganization or tissue regeneration in response to cellular injury?"]}, "no_questions": {"contexual_properties": [], "properties": ["Can you observe skin that appears swollen, stretched, and shiny due to extensive fluid retention?", "Does the image show swelling with a normal capillary refill time, typically less than 2 seconds?", "Is there evidence of significant weight gain, possibly in the range of 5 to 20 kilograms or more?"], "relational": ["Does the image show alterations in organs such as the liver, kidneys, heart, or lungs that might be related to fluid overload?", "Is there visible involvement of tissues like connective or interstitial tissue with signs of fluid retention?", "Can you see features suggesting impaired lymphatic drainage or lymphatic dysfunction?"], "contexual_behavior": [], "functions": ["Is there evidence of increased distance between capillaries and cells that could impair nutrient or oxygen delivery?", "Can you identify visual cues that might suggest cardiovascular strain, such as signs consistent with increased preload or heart failure?", "Does the image reveal tissue changes that could result in impaired perfusion or cellular dysfunction?"]}}, "bile duct cells": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show cells that are between 10 and 20 micrometers in diameter?", "Can you identify cells with a cuboidal or columnar shape?", "Is there evidence of mononuclear cells present in the image?", "Do any cells display cytoplasm containing organelles such as mitochondria, endoplasmic reticulum, or Golgi apparatus?", "Are there cells that appear pale eosinophilic or light pink under the microscope?", "Can you see cells with moderate mitochondrial content, suggesting active transport or secretion?", "Are there cells that might express proteins like cytokeratin 7, cytokeratin 19, or epithelial cell adhesion molecule?", "Do any cells appear to have low lipid content under normal physiological conditions?", "Is there evidence of cells with minimal glycogen compared to neighboring hepatocytes?", "Can you identify cells whose cytoplasmic pH is likely to be around 7.0 to 7.4?", "Are there cells where water appears to constitute a significant portion of their mass, approximately 70\u201380%?", "Do you see cells with a density close to 1.05 grams per cubic centimeter?", "Are there cells that might express surface markers such as CK19, EpCAM, or MUC1?", "Can you identify cells with an estimated lifespan of several months?"], "relational": ["Does the image show cellular components of the digestive or hepatic system?", "Can you identify cells located within the liver?", "Is there evidence of structures such as bile ducts or intrahepatic ducts?", "Does the image display ducts lined by specialized cells?", "Are there cells surrounded by connective tissue or hepatic parenchyma?", "Can you see anatomical connections to features like the Canals of Hering or portal triads?", "Are there cells adjacent to hepatocytes or Kupffer cells?", "Does the image show cells participating in bile transport or secretion?", "Can you identify regions such as portal tracts or the biliary tree containing specialized cells?", "Is there a cellular component present within the biliary system or hepatic lobule?"], "contexual_behavior": [], "functions": ["Does the image show a structure that lines a conduit for bile flow from the liver to the gallbladder or intestine?", "Can you identify cells or regions involved in modifying or secreting bile?", "Is there evidence of a barrier protecting the biliary tract from toxins?", "Does the image display features consistent with secretion or absorption processes that regulate bile volume or composition?", "Can you see any indication of bicarbonate secretion or electrolyte regulation within the bile ducts?", "Is there a visible epithelial lining that could provide structural support or form tight junctions?", "Does the image suggest the presence of cells contributing to extracellular matrix production in the bile duct region?", "Can you identify structures that might be involved in immune surveillance or cytokine secretion in response to pathogens?", "Is there evidence of cellular proliferation or repair activity in response to injury or inflammation within the biliary tract?", "Does the image show features that could be associated with water transport or pH regulation in bile?", "Can you see any indication of paracrine signaling or immune modulation between cells in the liver region?", "Is there a visible interaction between the duct lining and neighboring hepatocytes or Kupffer cells?"]}, "no_questions": {"contexual_properties": ["Do any masses display a change in contrast relative to surrounding tissue, potentially reflecting changes in density or composition?", "Does the image show an increased number of masses, possibly indicating multifocal tumor development or new lesion formation?", "Are there any masses that have decreased in size, which might indicate a response to therapy or regression?"], "properties": ["Does the image contain an area that is slightly more hyperdense or light gray than the surrounding parenchyma?", "Can you find an area with a heterogeneous or inhomogeneous internal texture?", "Are calcifications rarely or infrequently observed within any of the subtle masses present?"], "relational": ["Can you identify a mass-like feature that appears within the breast parenchyma or mammary glands?", "Is there a subtle area that could be associated with microcalcifications?", "Is there a subtle abnormality present in the upper outer quadrant, central breast, or subareolar area?"], "contexual_behavior": ["Is there an area where a lesion appears more detectable, potentially due to transient changes in breast tissue during the luteal phase of the menstrual cycle?", "Can you see a mass with altered or irregular margins that could be associated with prior surgical intervention or architectural distortion?", "Is there a region in the image where dense tissue makes it difficult to distinguish the borders of a lesion?"], "functions": ["Is there evidence of structural heterogeneity or loss of organized tissue patterning?", "Are there subtle regions that appear denser or stiffer than the surrounding tissue?", "Is there visual evidence of increased cellular density or abnormal tissue organization?"]}}, "immunohistochemical stain": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show evidence of a staining procedure involving both antibodies and chromogenic substrates?", "Can you identify areas with a brown or red coloration that could result from the use of specific chromogens?", "Is there visual evidence of a reaction that might require a pH between 6.0 and 7.5 for optimal results?", "Does the staining intensity in the image appear weak, moderate, or strong, suggesting variable antigen expression?", "Can you observe a staining pattern that would indicate high specificity for a particular antigen?", "Is there evidence of a staining protocol that could achieve sensitivity greater than 90%?", "Does the image suggest the use of a liquid reagent at room temperature?", "Can you infer whether the staining procedure might have involved an incubation period ranging from 30 minutes to overnight?", "Is there any indication that the staining reagents used are soluble in aqueous buffers or organic solvents?", "Does the image suggest that the staining procedure required a small volume, such as 50 to 200 microliters per slide?", "Can you infer from the image whether the staining protocol might have used a dilution factor between 1:50 and 1:1000?", "Is there any visual clue that the staining reagents should be stored at temperatures between 2 and 8 degrees Celsius?", "Can you deduce from the staining pattern whether the antibodies used could have a molecular weight in the range of 150 to 160 kDa?", "Does the image suggest that the staining reagents might have a shelf life of 6 to 24 months depending on storage conditions?", "Is there evidence in the image that buffer solutions were used as part of the staining process?"], "relational": ["Does the image show a tissue sample that could be from a tumor or a normal organ?", "Can you identify a specimen that might be a biopsy section?", "Is there evidence of staining that highlights cellular structures such as membranes, nuclei, or cytoplasm?", "Does the image contain cells that could be epithelial cells, lymphocytes, or neurons?", "Can you see a tissue section from regions like lymph nodes, brain, breast, or prostate?", "Is there a sample that appears to be prepared for detecting specific antigens?", "Does the image show tissue from the nervous, immune, or endocrine system?", "Can you observe staining patterns that might indicate the presence of proteins or antigens?", "Is there visualization of cellular organelles such as nuclei or mitochondria?", "Can you see evidence of cell surface markers being highlighted?", "Does the image appear to be a histological slide prepared for visualizing specific molecules?", "Is there a specimen that could be formalin-fixed, paraffin-embedded tissue, a frozen section, or a cytology smear?"], "contexual_behavior": [], "functions": ["Does the image show evidence of a technique used to visualize specific antigens within tissue sections?", "Can you identify a method in the image that highlights the presence of particular proteins by producing a visible signal?", "Is there a visible indication of antibody binding to target antigens in the tissue sample?", "Does the image reveal areas where disease markers are detected through the presence or absence of specific molecular targets?", "Can you observe abnormal protein expression patterns that might aid in pathological diagnosis?", "Is there evidence of unique cellular markers being labeled to distinguish between different cell types?", "Does the image display localized color changes that correspond to the distribution of specific antigens?", "Can you identify features that would assist in classifying tumor origin or subtype based on tumor-specific antigen detection?", "Is there visual information suggesting the detection of markers indicative of particular stages or lineages of cell development?", "Does the image show labeling of pathogen-specific antigens that could indicate the presence of infectious agents?", "Can you observe visualization of immune cell markers or cytokine expression patterns that would support evaluation of immune responses in the tissue?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is the cytoplasmic-to-nuclear ratio preserved and similar to that of normal endometrial cells?", "Can you identify a region where the tissue thickness appears moderately increased, approximately 1 to 2 millimeters?", "Do the nuclei display a fine, evenly distributed chromatin pattern without hyperchromasia?"], "relational": ["Does the image show a histological section where the epithelial layer, glandular layer, or subepithelial stroma appears thickened but orderly?", "Can you identify an area where epithelial or glandular cells are more numerous but maintain normal nuclear appearance?", "Is there evidence of increased glandular or epithelial layers adjacent to the basement membrane or connective tissue, but without abnormal nuclear features?"], "contexual_behavior": ["Does the image suggest increased persistence of endometrial proliferation that could be associated with an immunocompromised state?", "Does the image reveal changes in endometrial growth dynamics that might be linked to perimenopausal hormonal fluctuations?", "Is there a region where endometrial tissue appears expanded, possibly due to prolonged estrogen exposure without opposing progestin?"], "functions": ["Is there a region where the architecture of the tissue appears preserved despite an apparent increase in cell density?", "Does the image show a tissue with an increased number of cells while maintaining normal cellular appearance and organization?", "Can you observe a shift toward cell growth over cell death, while overall tissue homeostasis and normal appearance are preserved?"]}}, "liver stem cells": {"yes_questions": {"contexual_properties": ["Does the image show an increase in the number of cells in regions associated with tissue regeneration or liver injury?", "Can you observe a decrease in the population of certain cells following signs of tissue repair or cell death?", "Is there evidence of cells changing in size, possibly indicating activation or differentiation processes?", "Do any cells exhibit altered morphology that could suggest a transition toward hepatocytes or cholangiocytes?", "Are there cells with abnormal inclusions that might indicate steatosis or a storage disease?", "Can you detect changes in marker expression levels among cells, potentially reflecting activation, differentiation, or disease states?", "Is there a region where cells appear more proliferative in response to liver damage or growth factor stimulation?", "Do you see changes in cell composition that could be linked to differentiation or microenvironmental influences?", "Are there cells with altered surface protein patterns, possibly due to activation, disease, or lineage specification?", "Can you identify dysplastic features in cells within areas affected by chronic liver disease or pre-neoplastic transformation?", "Is there evidence of increased apoptosis among cells, such as those exposed to toxic injury or cellular stress?", "Do any cells display changes in their differentiation potential under altered signaling or disease conditions?", "Are there cells with visible chromosomal abnormalities, suggesting genetic instability or malignancy?", "Can you observe enlarged cells that may be undergoing activation, senescence, or pathological stress?", "Do any cells show cytoplasmic changes consistent with differentiation, metabolic stress, or disease?", "Is there evidence of altered metabolic activity in cells responding to activation, differentiation, or environmental changes?", "Are there cells with vacuoles that could indicate cellular injury or metabolic disturbance?", "Do you notice abnormal staining patterns in cells, possibly due to disease, altered protein expression, or cellular damage?", "Is there a loss of typical cell shape that might be associated with apoptosis, necrosis, or malignant transformation?", "Can you identify cells with altered nuclear size, potentially reflecting activation, dysplasia, or neoplastic progression?"], "properties": ["Does the image show cells that are approximately 10 to 15 micrometers in diameter?", "Can you identify round or oval-shaped cells with a small size?", "Are there cells present that display a high nuclear-to-cytoplasmic ratio and scant cytoplasm?", "Is there evidence of cells that appear colorless or slightly basophilic under standard staining?", "Can you see cells that might express surface markers such as EpCAM, CD133, or CD90?", "Are there cells likely to have high levels of stemness genes like SOX9, NANOG, or OCT4?", "Do any cells exhibit moderate mitochondrial content, suggesting an undifferentiated state?", "Is there a population of cells with a higher proliferation rate than mature hepatocytes, possibly doubling every 24 to 48 hours?", "Can you identify cells that might have elevated telomerase activity compared to differentiated liver cells?", "Are there cells with a viability percentage above 85% under optimal conditions?", "Do any cells express proteins such as alpha-fetoprotein or cytokeratin 19, indicating early hepatic lineage?", "Is there a group of cells with low to moderate lipid content compared to mature hepatocytes?", "Can you observe cells with low cytoplasmic granularity due to minimal organelle content?", "Are there cells that could have a lifespan of several weeks to a few months in vitro?", "Is there evidence of cells containing approximately 6 picograms of DNA per diploid cell?", "Do any cells exhibit a diploid chromosomal content, specifically 46 chromosomes?", "Are there cells that would thrive in an environment with a pH between 7.2 and 7.4?"], "relational": ["Does the image show a structure that is part of the hepatic system?", "Can you identify a region within the liver that contains specialized canals, such as the canals of Hering?", "Is there evidence of cells that could give rise to hepatocytes or cholangiocytes?", "Does the image display areas where hepatic progenitor cells might be present?", "Can you see tissue regions that interact with the hepatic parenchyma or portal tracts?", "Is there a visible anatomical feature corresponding to periportal regions within the liver?", "Does the image include structures associated with branches of the portal vein or hepatic artery?", "Can you identify a region in the upper right abdominal quadrant that contains cellular niches?", "Is there a structure that could be related to the gallbladder or pancreas in proximity to the liver?", "Does the image show features consistent with a periportal niche or the canals of Hering?"], "contexual_behavior": ["Does the image show evidence of increased regenerative activity in response to acute liver injury, suggesting activation of a cell population when hepatocyte proliferation is insufficient?", "Is there a visible reduction in differentiation into hepatocytes in the context of chronic liver disease, possibly due to persistent inflammation?", "Can you identify a failure of cellular proliferation in a fibrotic microenvironment, such as might be seen in cirrhosis?", "Does the image suggest enhanced tissue repair following partial removal of liver tissue, indicating activation of a regenerative cell population?", "Is there a decline in the ability to repopulate damaged liver tissue in an aging context, potentially due to cellular senescence?", "Can you observe impaired cellular function in the presence of hepatotoxic drugs, possibly due to direct toxicity or altered signaling?", "Does the image indicate increased cellular activation in response to acute inflammation, perhaps stimulated by inflammatory cytokines?", "Is there evidence of regenerative capacity loss in areas with significant extracellular matrix deposition, as seen in fibrosis?", "Can you detect behavioral changes in response to immune-mediated injury, such as might occur during viral hepatitis infection?", "Does the image suggest reduced self-renewal or proliferation under oxidative stress, possibly due to reactive oxygen species damage?", "Is there an increase in differentiation toward biliary cells following bile duct injury, indicating a shift in lineage commitment?", "Can you see a failure to restore normal liver function in the context of metabolic liver disease, possibly due to genetic defects or persistent metabolic stress?", "Does the image show enhanced proliferation during liver regeneration after transplantation, suggesting abundant regenerative cues?", "Is there a reduction in cellular activity that could be attributed to impaired microenvironmental signaling, such as a lack of essential growth factors or extracellular matrix components?", "Can you observe altered cellular function in the setting of non-alcoholic fatty liver disease, potentially due to lipid accumulation and inflammation?", "Does the image indicate an increased response to growth factors during tissue repair, possibly due to upregulation of receptor expression?", "Is there a failure of cellular activation in the context of end-stage liver disease, potentially due to extensive tissue damage or stem cell exhaustion?", "Can you detect a decline in regenerative output during chronic alcohol exposure, possibly as a result of ethanol toxicity?", "Does the image suggest increased migration of cells to sites of injury, potentially in response to chemokines or damage-associated signals?", "Is there evidence of impaired differentiation in the context of genetic liver disorders, possibly due to inherited mutations affecting lineage specification?"], "functions": ["Does the image show any cells that might be involved in self-renewal or differentiation to maintain liver tissue?", "Can you identify structures that could contribute to liver regeneration by forming new hepatocytes or cholangiocytes after injury?", "Is there evidence of cells participating in tissue repair by replacing lost or damaged liver cells?", "Does the image display cells that appear activated, proliferating, or migrating toward areas of liver damage?", "Can you see any cellular activity that suggests maintenance of liver homeostasis through replenishment of mature liver cells?", "Is there visual indication of cells differentiating into specialized liver cell types, possibly guided by microenvironmental cues?", "Does the image show evidence of hepatocyte replacement through proliferation and differentiation?", "Are there features suggesting the formation of major hepatic cell lineages during liver development?", "Can you observe any signs of cellular turnover, where a balance between self-renewal and differentiation is maintained?", "Is there visual evidence of tissue regeneration or anti-fibrotic effects that might occur during chronic liver disease repair?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there evidence of a well-vascularized layer containing numerous small blood vessels beneath another structure?", "Is there a region that would be expected to have a slightly alkaline pH, around 7.35 to 7.45?", "Does the image show a layer that could exhibit moderate elasticity due to elastin and collagen fibers?"], "relational": ["Is there evidence of connective tissue, such as lamina propria or submucosa, situated beneath a mucosal or epithelial layer?", "Can you identify a tissue interface in the skin, oral cavity, or gastrointestinal tract where support and nourishment are provided to an overlying layer?", "Does the image contain features such as extracellular matrix, blood vessels, or nerve fibers supporting a layer beneath an epithelium?"], "contexual_behavior": ["Can you identify areas that might be experiencing reduced blood flow or oxygen delivery, indicating possible ischemia or hypoxia?", "Can you identify delayed healing or poor matrix formation in areas where nutrient deficiency or malnutrition may be present?", "Are there features such as necrosis or ulceration that might result from prolonged pressure exposure and functional changes beneath the surface?"], "functions": ["Can you identify areas where capillary networks facilitate the exchange of gases or nutrients with surrounding tissues?", "Does the image reveal a structure that connects or anchors different tissue layers, contributing to overall stability?", "Is there evidence of tissue that might participate in wound healing, such as the presence of fibroblasts or extracellular matrix components?"]}}, "oval cells": {"yes_questions": {"contexual_properties": ["Does the image show an increased population of cells in the liver that might indicate impaired proliferation of the main parenchymal cells during injury or regeneration?", "Can you identify a decrease in a specific cell type as liver recovery progresses and normal parenchymal cells are restored?", "Is there evidence of cells changing in size in regions associated with liver damage or repair processes?", "Does the image reveal a prominence of certain cells in areas affected by chronic liver disease, cirrhosis, or exposure to hepatotoxic substances?", "Are there cells with abnormal morphology present in regions showing signs of fibrosis or carcinogenesis?", "Can you observe an accumulation of cells in the liver following severe or chronic hepatic injury, or in experimental regeneration models?", "Do any cells exhibit altered staining properties in areas corresponding to activation, differentiation, or pathological stimuli?", "Is there a population of cells with an increased nuclear-to-cytoplasmic ratio in regions suggestive of malignant transformation or high proliferative activity?", "Are there clusters of cells showing increased proliferation in response to liver injury, especially where replication of the main parenchymal cells appears suppressed?", "Can you detect cells with atypical cytoplasm in areas displaying features of dysplasia or neoplastic transformation?", "Are there cells containing vacuoles in regions that might be experiencing cellular stress, degeneration, or metabolic disturbance?", "Do any cells display changes in marker expression in association with activation, lineage commitment, or disease progression?", "Is there evidence of multinucleated cells in areas affected by abnormal mitosis or cellular stress during liver pathology?", "Can you see cells with granular cytoplasm in regions undergoing activation, degeneration, or metabolic changes?", "Are there cells with altered surface characteristics in areas where differentiation or microenvironmental cues are likely present?", "Do any cells appear larger than normal in regions associated with activation, transformation, or pathological states?", "Is there a clustering of cells in regions of active regeneration or chronic injury within the liver?", "Can you identify an increased number of mitotic figures among cells in areas of rapid proliferation following liver damage?", "Are there cells with altered chromatin patterns in regions suggestive of neoplastic transformation or high-grade dysplasia?", "Do any cells appear more resistant to staining in areas affected by cellular degeneration or altered membrane properties?"], "properties": ["Is there a cell in the image that measures approximately 10 to 15 micrometers in length?", "Can you identify a cell with an average diameter close to 10 micrometers?", "Does the image show a cell with an elongated, ovoid shape?", "Is there a cell that appears basophilic or blue-purple under standard staining?", "Can you find a cell displaying a high nuclear-to-cytoplasmic ratio?", "Is there a cell with scant cytoplasm and visible organelles such as mitochondria or endoplasmic reticulum?", "Does the image contain a mononuclear cell?", "Can you identify a cell expressing markers such as CK19, EpCAM, AFP, or OV6?", "Is there a cell with low cytoplasmic granularity?", "Does the image show a cell type that is typically transient and present for only days to weeks during liver injury?", "Can you find a diploid cell with normal somatic DNA content?", "Is there a cell expressing proteins characteristic of progenitor or biliary lineages, such as CK19, albumin, or AFP?", "Does the image contain a cell with moderate mitochondrial content?", "Can you identify a cell with a surface area estimated between 150 and 200 square micrometers?", "Is there a cell maintaining a membrane potential in the range of -40 to -60 millivolts, similar to other progenitor cells?"], "relational": ["Does the image show cells associated with the hepatic system?", "Can you identify cells located within the periportal area of liver tissue?", "Is there evidence of hepatic progenitor cells emerging in response to liver injury or regeneration?", "Does the image contain cells that are related to hepatocytes, cholangiocytes, or hepatic stellate cells?", "Are there cells interacting with bile ducts, hepatic sinusoids, or portal tracts?", "Can you see cells positioned near the canals of Hering in the periportal region?", "Is there a cell population closely connected to bile ducts, potentially differentiating into cholangiocytes?", "Does the image contain cells belonging to the hepatic progenitor cell lineage?", "Are there cells supported by or surrounded by the extracellular matrix, portal tracts, or sinusoidal endothelium?", "Can you identify progenitor cells structurally related to hepatic stem cells or ductular progenitor cells?"], "contexual_behavior": ["Is there evidence of increased progenitor cell proliferation in regions where hepatocyte replication appears impaired, such as after severe or chronic liver damage?", "Can you identify cells that show enhanced differentiation into hepatocytes in areas with signs of acute liver injury and regeneration?", "Does the image reveal reduced regenerative activity of progenitor cells in the presence of chronic liver disease or fibrotic changes?", "Are there regions where progenitor-mediated regeneration appears absent following toxic damage, suggesting disrupted activation or differentiation pathways?", "Is there increased proliferation and ductular reaction in response to biliary obstruction visible in the tissue?", "Do you observe a decrease in progenitor cell function in areas that may correspond to aging liver tissue?", "Is there evidence of impaired differentiation of progenitor cells in fibrotic regions, possibly due to extracellular matrix alterations?", "Can you see increased activity of progenitor cells in response to partial hepatectomy when hepatocyte proliferation seems insufficient?", "Are there visual cues indicating altered proliferation or differentiation patterns of progenitor cells in response to inflammatory cytokines or immune cell infiltration?", "Does the image show a lack of progenitor cell proliferation after exposure to toxins that might directly damage these cells or disrupt signaling pathways?", "Is there reduced contribution to tissue repair by progenitor cells in areas with advanced cirrhosis and extensive fibrosis?", "Can you identify increased progenitor cell involvement in liver regeneration following significant hepatocyte loss, such as after viral hepatitis?", "Are there signs of reduced regenerative function of progenitor cells in regions affected by oxidative stress or cellular damage?", "Is there a shift towards cholangiocyte differentiation by progenitor cells in areas with bile duct injury or cholestasis?", "Do you observe enhanced activation of progenitor cells in the context of metabolic liver diseases like nonalcoholic steatohepatitis?", "Is there a decrease in progenitor cell contribution to regeneration after repeated injury, possibly due to cell exhaustion or microenvironmental changes?", "Are there indications of impaired differentiation and reduced regenerative capacity of progenitor cells in regions with steatosis?", "Can you see increased progenitor cell activity in response to acute liver failure where massive hepatocyte loss is evident?", "Does the image suggest failed regeneration due to impaired stem cell signaling or disrupted activation and differentiation pathways?", "Are there areas where progenitor cells show increased proliferation or signs of malignant transformation following exposure to carcinogens?"], "functions": ["Does the image show cells that can give rise to both hepatocytes and bile duct cells?", "Is there evidence of progenitor cells contributing to the regeneration of liver tissue?", "Can you identify cells that proliferate in response to impaired hepatocyte replication?", "Does the image contain a cellular reservoir involved in replenishing damaged liver parenchyma?", "Are there cells visible that migrate toward sites of liver injury to aid in tissue recovery?", "Can you see cells participating in the formation of bile ducts by differentiating into ductal epithelium?", "Is there evidence of lineage commitment pathways leading to the generation of both hepatocytes and cholangiocytes?", "Are there cells contributing to the remodeling and regeneration of functional liver architecture?", "Does the image show cells interacting with the liver microenvironment, such as responding to signaling molecules or extracellular matrix components?", "Can you identify cells involved in modulating fibrogenic responses or interacting with hepatic stellate cells during liver fibrosis?", "Is there evidence of new functional hepatocytes and cholangiocytes being generated to restore liver function after damage?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an object in the image whose size could range from a few micrometers to several centimeters?", "Does the image contain an object whose mass could vary greatly depending on its size and composition?", "Can you identify an object whose consistency ranges from soft and pliable to firm and brittle?"], "relational": ["Does the image show an obstruction within a blood vessel such as an artery, vein, or capillary?", "Is there a sign of a material that could have originated from the heart and is now causing a blockage elsewhere in the circulatory system?", "Can you identify a blockage that could affect the lungs, brain, heart, or kidneys?"], "contexual_behavior": [], "functions": ["Is there a visible sign of tissue ischemia, such as pallor or discoloration, that might result from impaired blood supply?", "Does the image suggest tissue necrosis or infarction in an area supplied by a blocked vessel?", "Can you observe any signs of organ dysfunction or ischemic injury that could be linked to impaired perfusion?"]}}, "canals of hering": {"yes_questions": {"contexual_properties": ["Is there a structure in the image that appears dilated, which could suggest cholestasis or an obstructive liver disease?", "Can you identify any features that appear narrowed, possibly indicating chronic inflammation or hepatic fibrosis?", "Does the image show increased cellularity in a region, which might be a response to liver injury or regeneration?", "Is there evidence of fibrosis in a duct-like structure, as seen in chronic liver diseases such as primary biliary cholangitis?", "Are there signs of inflammatory changes in a small duct, which could be associated with autoimmune or infectious cholangitis?", "Can you see any structures that appear obstructed or blocked, potentially due to bile duct obstruction or bile plugging?", "Is there visible proliferation of epithelial cells in a ductular region, suggestive of a ductular reaction or liver regeneration?", "Do you observe any changes in the diameter of a small duct, possibly reflecting altered bile flow or a pathological process?", "Are there accumulations of bile plugs in a canal-like structure, which could indicate cholestasis or bile stasis?", "Does the image show loss of normal architecture in a ductular area, as might occur in advanced liver disease or cirrhosis?", "Is there a region where duct-like structures appear more prominent, which could be a sign of ductular reaction or chronic liver injury?", "Can you identify deposition of abnormal material within a small duct, possibly related to metabolic liver disease or cholestatic disorders?", "Is there evidence of increased branching in a ductular network, which might be seen during regeneration or chronic injury?", "Do you see thickening of the walls of a small canal, which could be due to chronic inflammation or fibrosis?", "Are there regions where staining properties of a ductular structure are altered, as might be observed in cholestasis or during a ductular reaction?"], "properties": ["Does the image show a short, tubular, and branching structure with a diameter between 10 and 15 micrometers?", "Can you identify a structure that measures approximately 50 to 100 micrometers in length?", "Is there a feature lined by both hepatocytes and cholangiocytes?", "Can you see a transition in the epithelial lining from hepatocytes to cuboidal cholangiocytes?", "Does the image contain a structure with a wall thickness of about 1 to 2 micrometers?", "Is there a pale pink to eosinophilic staining pattern visible in a small tubular structure?", "Can you identify one or two such structures per liver lobule?", "Is there evidence of a structure with high water content, similar to other bile duct components?", "Does the image show a feature with moderate protein content, including cytokeratins and junctional proteins in its lining?", "Can you see a structure whose tissue density is similar to other soft tissues, around 1.05 g/cm\u00b3?", "Is there a visible extracellular matrix containing collagen types I and IV, laminin, and fibronectin?", "Can you identify a structure where the oxygen concentration is intermediate between portal blood and hepatocytes, approximately 30 to 40 mmHg?", "Is there evidence of a bile flow rate through a small duct at about 0.5 to 1.0 microliters per minute per gram of liver?", "Does the image show a structure with a neutral pH, close to 7.4?"], "relational": ["Does the image show a structure that is part of the hepatobiliary system?", "Can you identify a feature located within the liver that connects bile canaliculi to interlobular bile ducts?", "Is there a conduit visible between bile canaliculi and interlobular bile ducts?", "Does the image contain a region lined by both cholangiocytes and hepatocytes?", "Can you see a structure situated in the periportal region or portal tract of the liver?", "Is there an anatomical feature that receives bile from bile canaliculi?", "Does the image show a structure that drains into interlobular bile ducts?", "Can you identify a region in the periportal area of the liver associated with bile transport?", "Is there a visible connection between hepatic lobules and portal triads within the biliary system?"], "contexual_behavior": [], "functions": ["Does the image show a structure that acts as a transitional duct for bile conduction between hepatocytes and the bile duct system?", "Can you identify a conduit that channels bile from canaliculi into interlobular bile ducts?", "Is there an anatomical bridge visible that connects bile canaliculi with intrahepatic bile ducts?", "Does the image contain a feature that regulates bile flow by providing a controlled passage between small canaliculi and larger bile ducts?", "Can you see a region that could serve as a niche for hepatic progenitor cells involved in liver regeneration?", "Is there a specialized microenvironment present that supports the maintenance and activation of hepatic progenitor cells?", "Does the image show a structure that could supply progenitor cells for liver repair or repopulation of damaged hepatic or biliary tissue?", "Can you identify a feature that helps preserve the integrity and continuity of the biliary system by linking hepatocytes to bile ducts?"]}, "no_questions": {"contexual_properties": ["Is there visual indication of metastatic spread involving the lining of the abdominal cavity and affecting female reproductive structures?", "Can you identify any lesions or nodules present on the serosal surfaces of pelvic organs?", "Does the image show evidence of abnormal tissue growth on the outer surfaces of reproductive organs such as the uterus or ovaries?"], "properties": ["Can you identify lesions or nodules attached to the serosal layer of the uterus?", "Is there evidence of pathological implants on the outer surface of the ovaries?", "Are there visual signs of disease affecting both the uterus and ovaries at their outermost layers?"], "relational": ["Are there visible abnormalities in regions like the pouch of Douglas or the uterovesical pouch?", "Does the image reveal changes on the uterine or ovarian surfaces consistent with involvement of the pelvic peritoneum?", "Does the image show involvement of anatomical boundaries such as the broad ligament or mesovarium?"], "contexual_behavior": ["Can you identify any lesions or nodules present on the serosal lining of pelvic organs?", "Does the image reveal any irregularities or masses on the surfaces of organs within the pelvic cavity?", "Is there visual indication of metastatic deposits on the peritoneal surfaces adjacent to female reproductive structures?"], "functions": ["Does the image show signs of edema or vascular compromise near the serosal surfaces of pelvic organs?", "Does the image suggest the presence of immune cell infiltration or inflammation in the peritoneal cavity?", "Is there visual indication of mechanical compression or inflammation impacting the function of reproductive organs?"]}}}
|
|
[
{
"answer": "foci of fat necrosis",
"extracted_concepts": [
"areas of white chalky deposits",
"foci of fat necrosis"
],
"question": "what do the areas of white chalky deposits represent?"
},
{
"answer": "with calcium soap formation (saponification)",
"extracted_concepts": [
"calcium soap formation",
"saponification",
"foci of fat necrosis",
"white chalky deposits"
],
"question": "how do the areas of white chalky deposits represent foci of fat necrosis?"
},
{
"answer": "yes",
"extracted_concepts": [
"areas of white chalky deposits",
"calcium soap formation",
"sites of lipid breakdown",
"foci of fat necrosis",
"mesentery"
],
"question": "do the areas of white chalky deposits represent foci of fat necrosis with calcium soap formation at sites of lipid breakdown in the mesentery?"
},
{
"answer": "no",
"extracted_concepts": [
"calcium soap formation",
"histone subunits",
"sites of lipid breakdown",
"foci of fat necrosis",
"mesentery"
],
"question": "do the histone subunits represent foci of fat necrosis with calcium soap formation at sites of lipid breakdown in the mesentery?"
},
{
"answer": "the areas of white chalky deposits",
"extracted_concepts": [
"calcium soap formation",
"white chalky deposits",
"sites of lipid breakdown",
"foci of fat necrosis",
"mesentery"
],
"question": "what represent foci of fat necrosis with calcium soap formation at sites of lipid breakdown in the mesentery?"
},
{
"answer": "at sites of lipid breakdown in the mesentery",
"extracted_concepts": [
"calcium soap formation",
"white chalky deposits",
"sites of lipid breakdown",
"foci of fat necrosis",
"mesentery"
],
"question": "where do areas of white chalky deposits represent foci of fat necrosis with calcium soap formation?"
}
] |
["saponification", "areas of white chalky deposits", "calcium soap formation", "white chalky deposits", "histone subunits", "foci of fat necrosis", "mesentery", "sites of lipid breakdown"]
|
{"saponification": {"yes_questions": {"contexual_properties": ["Does the image show areas where fat appears to have undergone necrosis, possibly with visible deposits?", "Can you identify regions with white or pale chalky deposits within tissue, suggesting a reaction with calcium?", "Is there evidence of firmer or less elastic tissue where fat would normally be present?", "Do you observe opaque regions in the tissue matrix that could indicate the accumulation of insoluble soaps?", "Are there larger zones of fat necrosis that might be associated with extensive injury or pancreatitis?", "Can you see tissue areas with altered color or texture, possibly due to the replacement of fat by soap deposits?", "Is there an increase in the mass or density of tissue where mineral or soap deposits have accumulated?", "Do microscopic features include amorphous basophilic deposits or ghost-like outlines of fat cells?", "Is there a loss of normal tissue elasticity in regions where rigid deposits have formed?", "Can you identify tissue changes that might result from elevated temperature or high alkali concentration?", "Are there signs of increased calcium content or binding within areas of fat necrosis?", "Do you observe any variation in deposit appearance that could be due to different types of fatty acids or metal ions?"], "properties": ["Does the image show a process or setup where the temperature appears to be maintained between 40\u00b0C and 80\u00b0C?", "Is there evidence of a reaction environment with a pH likely between 10 and 14?", "Can you identify a process that might require 30 to 60 minutes to complete?", "Does the image display products that could include both a solid (such as a white or off-white substance) and a liquid phase?", "Is there a visible indication of a chemical reaction involving a 1:1 ratio of triglyceride to alkali?", "Can you see evidence suggesting a high yield (between 90% and 98%) of a solid product?", "Does the setup appear to use an alkali concentration in the range of 10% to 20% by weight?", "Is there a solid product present that could have a density between 0.8 and 1.1 g/cm\u00b3?", "Can you observe a solid substance whose melting point might be in the range of 100\u00b0C to 130\u00b0C?", "Does the image show a product mixture where the solid phase could contain 60% to 80% fatty acids by weight?", "Is there a liquid component that could represent 8% to 12% of the total product mixture?", "Can you see a process or apparatus that might release a mild amount of heat, consistent with an enthalpy change of \u201350 to \u2013100 kJ/mol?", "Is there a solid product whose color is white or off-white, possibly influenced by the starting materials?", "Does the image suggest a final product with a water content of 10% to 30% before drying?"], "relational": ["Does the image show evidence of a chemical process occurring in fatty tissue where triglycerides might react with calcium to form soap-like deposits?", "Can you identify any abnormal changes in the pancreas or subcutaneous regions that could indicate a reaction between adipose tissue and calcium?", "Is there a visible area in the abdominal cavity or peripancreatic region that appears to contain calcified or soap-like material?", "Does the image reveal any tissue changes suggestive of fat necrosis, especially in association with pancreatic injury or trauma?", "Are there signs of tissue calcification, inflammation, or fibrosis within fatty or subcutaneous tissues?", "Can you see any regions where adipocytes or macrophages appear to be involved in a pathological process with calcium ions?", "Is there evidence of a process affecting the digestive, integumentary, or endocrine systems that could be linked to fat necrosis or tissue calcification?", "Does the image show any structural changes in the breast or subcutaneous fat that might be associated with the formation of calcium soaps?", "Are there visual cues indicating the presence of acute pancreatitis with associated fat necrosis or calcification?"], "contexual_behavior": ["Does the image show evidence of increased pathological calcification within adipose tissue, suggesting the formation of insoluble deposits?", "Is there any indication of fat necrosis in association with acute inflammation of the pancreas, which could lead to enhanced soap formation?", "Can you identify features that might suggest tissue trauma, such as disrupted cell membranes, which could facilitate the formation of soaps?", "Does the image reveal changes in postmortem tissues, such as areas of fat breakdown and soap-like deposits?", "Is there visual evidence of impaired fat breakdown, such as reduced soap formation, that might be consistent with pancreatic enzyme deficiency?", "Can you see signs that might indicate chronic liver disease, such as impaired bile production, which could reduce the breakdown and saponification of fats?", "Is there any indication of altered mineral deposition, such as the presence of magnesium-containing soaps with different texture or solubility compared to calcium deposits?", "Does the image suggest tissue dehydration, which could result in less efficient fat hydrolysis and reduced soap formation?", "Are there features consistent with hypothermic tissue, where reduced enzymatic activity might lead to inefficient fat breakdown and soap formation?", "Can you identify areas where excessive fat accumulation might provide more substrate for enzymatic breakdown and increased soap formation?", "Is there evidence of low calcium availability, such as decreased or absent insoluble soap deposits in fatty tissues?", "Does the image suggest a low pH environment, which could inhibit the reaction between fatty acids and bases and reduce soap formation?", "Are there visual cues indicating the presence of strong alkali, which could promote the hydrolysis of triglycerides and enhance soap formation?", "Can you detect signs of impaired lipase activity, such as a lack of free fatty acids and reduced soap deposits in fatty tissues?", "Is there any indication that a high concentration of fatty acids is present, which could accelerate the formation of soaps in the tissue?"], "functions": ["Does the image show evidence of a chemical reaction where fatty acids have combined with calcium to form insoluble deposits?", "Can you identify areas where fat breakdown has resulted in the formation of soap-like substances within tissue?", "Is there visual evidence of tissue changes consistent with fat necrosis, such as chalky or white deposits?", "Does the image display features suggesting the conversion of triglycerides or free fatty acids into insoluble materials in the presence of calcium?", "Are there visible deposits that could indicate the sequestration of fatty acids as calcium soaps within tissue?", "Can you see signs of tissue injury or necrosis associated with the formation of white, chalky material?", "Is there evidence of pathological calcification in organs such as the pancreas or breast, characterized by soap-like deposits?", "Does the image reveal areas where fatty acids appear to be immobilized as insoluble substances, possibly reducing local toxicity?", "Can you identify regions where the tissue response to injury includes the deposition of soap-like material?", "Is there a visible hallmark of fat necrosis, such as the transformation of released fatty acids into calcium-rich deposits?", "Does the image show tissue changes that could result from the precipitation of fatty acids with calcium, forming visible deposits?", "Are there features suggesting the emulsification or breakdown of fats beyond normal enzymatic digestion, possibly involving chemical soap formation?", "Can you see evidence of fat hydrolysis followed by the formation of insoluble calcium-containing material in the tissue?", "Is there a region where the removal or sequestration of fatty acids has led to the accumulation of chalky deposits?", "Does the image contain signs of detoxification of fatty substances through their conversion into insoluble, soap-like forms?"]}, "no_questions": {"contexual_properties": ["Can you identify any signs of posterior or superior displacement of a bony structure that might reduce the diameter of the foramen magnum?", "Are there signs of altered cerebrospinal fluid pathways due to narrowing at the foramen magnum?", "Does the image reveal any compression or impingement on the brainstem or upper spinal cord?"], "properties": ["Does the angulation of a bony process relative to the base of the skull exceed 110 degrees?", "Does the MRI show a region of hyperintensity on T2-weighted images in the upper cervical area, possibly indicating edema or myelopathy?", "Is there a structure with an abnormal, tilted, malformed, or hypoplastic appearance in the upper cervical region?"], "relational": ["Does the articulation between the axis and the occipital bone appear abnormal in the image?", "Is there evidence of reduced space for the vertebral arteries as they pass through the foramen magnum?", "Does the image show any abnormal alignment between the first and second cervical vertebrae?"], "contexual_behavior": ["Does the image show evidence of abnormal alignment between the first and second cervical vertebrae?", "Does the image reveal any relationship between cervical vertebral misalignment and reduced space for neural structures at the craniovertebral junction?", "Is there visible narrowing of the opening at the base of the skull through which the spinal cord passes?"], "functions": ["Can you see anatomical changes that might affect respiratory centers in the medulla or descending respiratory pathways?", "Does the image show signs consistent with myelopathy, such as changes in the spinal cord or altered reflex pathways below the craniovertebral junction?", "Does the image suggest possible disruption of motor or sensory pathways, potentially resulting in weakness or sensory loss?"]}}, "areas of white chalky deposits": {"yes_questions": {"contexual_properties": ["Does the image show any regions that appear larger than others, possibly indicating progression of fat necrosis or calcification?", "Are there areas that seem to have decreased in size, suggesting healing or reabsorption by the body?", "Can you identify multiple similar regions, which might indicate disease spread or multifocal tissue injury?", "Are there any regions that have changed color, possibly due to infection, hemorrhage, or changes in the local tissue environment?", "Do any areas appear firmer or denser, which could suggest increased mineralization or calcification?", "Is there evidence of softening in any region, potentially due to enzymatic breakdown or inflammation?", "Can you see new regions appearing in locations that suggest recent tissue damage or necrosis?", "Are there areas that stand out more due to thinning of overlying tissue or increased local inflammation?", "Do any regions display a change in texture, possibly reflecting ongoing metabolic or inflammatory processes?", "Are there areas that are less visible, perhaps due to reabsorption, tissue regeneration, or reduced density?", "Can you identify regions that appear denser, which might be due to additional calcium or mineral accumulation?", "Are there areas that seem less dense, possibly indicating mineral loss or partial dissolution?", "Is there visible evidence of inflammation, such as swelling or redness, around any of these regions?", "Do any areas appear surrounded by redness, suggesting local inflammation or increased blood flow?", "Are there regions with irregular borders, which could indicate uneven pathological processes or tissue breakdown at the margins?", "Can you see signs of tissue breakdown, such as necrosis or ulceration, associated with any of these regions?", "Are there regions that appear to have undergone further calcification, possibly due to chronic inflammation or ongoing injury?", "Is there evidence that any of these regions have resolved or disappeared, suggesting spontaneous healing and reabsorption?", "Do any areas show changes in their internal composition, possibly due to metabolic or inflammatory shifts?", "Are there regions associated with signs of pain or tenderness, such as local swelling or secondary infection?"], "properties": ["Does the image show any regions that appear white or off-white in color?", "Can you identify any areas with a dry, brittle, or powdery texture?", "Are there any structures that look irregular, amorphous, or form nodules or plaques?", "Is there a region that appears matte, non-reflective, or has a granular surface?", "Can you see any deposits that are opaque or highly opaque compared to surrounding tissues?", "Are there areas whose size ranges from a few millimeters to several centimeters?", "Is there a structure whose thickness appears less than a few millimeters?", "Can you identify any regions that might have a relatively low density compared to bone?", "Do any deposits appear to have a moderate hardness, similar to a Mohs hardness of 3?", "Is there evidence of a region with high calcium content, possibly exceeding 30% by weight?", "Can you see any deposits that might contain phosphate or traces of magnesium?", "Are there areas that seem to have low water content, appearing especially dry?", "Do any regions have a neutral to slightly alkaline appearance or context?"], "relational": ["Does the image show any regions within adipose tissue or pancreatic parenchyma that appear abnormal?", "Can you identify any features in the digestive, musculoskeletal, or cardiovascular systems that might indicate a pathological process?", "Is there evidence of abnormal deposits in the pancreas, subcutaneous tissue, or arteries?", "Are there structures adjacent to blood vessels, connective tissue, or epithelial layers that appear altered?", "Can you see areas where macrophages, fibroblasts, or necrotic cells might be present?", "Is there visual evidence of fibrosis, inflammation, or encapsulation in the surrounding connective tissue?", "Does the image show any changes in the pancreas, heart, or kidneys that could suggest a pathological process?", "Are there regions where tissue architecture, vascular integrity, or cellular composition appear disrupted?", "Can you identify areas where blood, interstitial fluid, or lymph might be interacting with abnormal deposits?", "Is there a visible structure resembling a calcified plaque, infarct, or tumor mass that contains distinct regions?"], "contexual_behavior": ["Does the image show regions that have increased in size in association with ongoing cell death or persistent calcium release?", "Can you identify areas that appear more prominent in the context of chronic inflammation or sustained tissue damage?", "Is there evidence of deposits that have not resolved despite apparent treatment, suggesting an unresolved underlying cause such as abnormal calcium metabolism?", "Do any regions seem to have decreased following restoration of normal calcium and phosphate balance?", "Are there features present that could be impairing tissue function, possibly related to a metabolic disorder involving calcium or phosphate dysregulation?", "Can you see accumulations that are more pronounced in areas where blood flow may be reduced, indicating possible ischemia and necrosis?", "Is there visual evidence of deposits that could be interfering with organ function in the setting of elevated circulating calcium levels?", "Do any areas appear less prominent after what might be correction of an underlying disease or normalization of metabolic processes?", "Are there regions that have increased in association with prolonged tissue necrosis or ongoing cell death?", "Can you observe changes in the appearance of deposits that might correspond to alterations in local pH or tissue environment affecting calcium salt solubility?"], "functions": ["Does the image show any regions where tissue appears stiffened or less elastic compared to surrounding areas?", "Can you identify areas that might disrupt normal nutrient exchange or cellular signaling within the tissue?", "Is there evidence of local tissue damage or impaired organ function that could be linked to mineral accumulation?", "Does the image contain regions that could trigger an inflammatory response, such as areas with immune cell infiltration?", "Are there visible signs of tissue rigidity or brittleness that might indicate altered mechanical properties?", "Can you see any areas where healing appears delayed or where tissue regeneration seems impaired?", "Is there evidence of obstruction or decreased compliance in an organ that could be caused by abnormal deposits?", "Do you observe any features suggesting metabolic impairment or reduced oxygen delivery to cells in a specific region?", "Are there regions that might contribute to chronic inflammation or ongoing tissue degeneration?", "Can you identify areas where normal enzymatic activity could be inhibited due to changes in the local biochemical environment?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Is there an organ located adjacent to the bladder or rectum?", "Does the image contain a structure positioned near the ovaries?", "Is there a visible anatomical connection between a structure and the vagina?"], "contexual_behavior": [], "functions": ["Does the image show a structure essential for fertility, pregnancy support, or menstrual health?", "Is there evidence of an organ that expands during pregnancy to accommodate a growing fetus?", "Can you see a tissue that supplies nutrients and removes waste for fetal development?"]}}, "calcium soap formation": {"yes_questions": {"contexual_properties": ["Does the image show areas within tissues that appear chalky-white or have a gritty texture, suggesting the presence of saponification?", "Can you identify regions that appear firmer or harder than surrounding tissue, possibly due to calcification in necrotic fat?", "Are there visible macroscopic deposits or radiopaque areas that could indicate increased radiodensity from calcified fat?", "Does the image reveal any palpable masses or nodules that might result from fat necrosis and calcium accumulation?", "Is there evidence of tissue remodeling where normal fat seems to be replaced by denser, insoluble material?", "Can you observe changes in tissue appearance that might be associated with chronic inflammation or acute pancreatitis?", "Are there signs of increased density or radiopacity in regions where fat breakdown and saponification may have occurred?", "Does the image suggest the presence of fat necrosis, such as areas of altered texture or color within fatty tissue?", "Can you see any features that might regress or resolve with treatment, such as reduction in size or disappearance of dense deposits?", "Is there visual evidence of organ involvement where abnormal deposits are present in association with tissue injury or disease progression?"], "properties": ["Does the image show granular or chalky deposits within tissue?", "Can you identify any structures with a white or pale yellow color?", "Is there evidence of amorphous or microcrystalline material present?", "Do you see deposits ranging in size from micrometers to several millimeters?", "Are there firm, gritty, or chalky textures visible in the tissue?", "Can you find deposits that might be insoluble in water?", "Is there a structure with a density similar to 1.3 to 1.4 g/cm\u00b3?", "Are there deposits located in areas of necrotic fat, such as the pancreas or subcutaneous tissue?", "Do you observe material that could form at a neutral to slightly alkaline pH, around 7.0 to 8.5?", "Is there evidence of deposits with high concentrations of calcium and fatty acids?", "Can you see material with a refractive index likely between 1.47 and 1.52?", "Are there deposits with a hardness similar to soft chalk?"], "relational": ["Does the image show evidence of fat necrosis in tissues such as the pancreas or subcutaneous regions?", "Can you identify any nodules or lesions within adipose tissue that might indicate saponification?", "Is there a visible structure in the abdominal cavity or breast that could be associated with mineral deposits like dystrophic calcification?", "Does the image contain areas where adipocytes or necrotic cells are present alongside calcified material?", "Can you see any features suggestive of lipase activity leading to saponification within fatty tissue?", "Is there a region in the digestive or integumentary system displaying signs of fat necrosis nodules or calcified lesions?", "Does the image include pancreatic tissue with evidence of pseudocyst formation or calcification?", "Can you identify any interaction between the pancreas, liver, and surrounding adipose tissue that might indicate a pathological process?", "Are there deposits resembling calcium phosphate within areas of fat necrosis?", "Is there a structure in the subcutaneous tissue or breast that could be associated with the formation of calcium-containing soaps?"], "contexual_behavior": ["Does the image show evidence of increased binding between unabsorbed fatty acids and calcium ions in the intestine, which might occur during fat malabsorption?", "Is there a visual indication of reduced soap-like deposits in the gut that could suggest low dietary calcium intake during fat malabsorption?", "Can you identify features consistent with impaired fat digestion due to reduced pancreatic enzyme activity, as might be seen in pancreatic insufficiency?", "Does the image suggest an increase in unabsorbed fatty acids reacting with calcium, possibly due to excess dietary fat?", "Is there evidence of decreased unabsorbed fatty acids in the intestine, as might be expected after bile acid supplementation?", "Can you see signs of persistent fat malabsorption and elevated unabsorbed fatty acids in the gut, as might occur in chronic pancreatitis?", "Does the image suggest reduced formation of insoluble deposits due to low dietary calcium intake?", "Is there visual evidence of large amounts of unabsorbed fat in the stool, which could promote the formation of insoluble complexes with intestinal calcium as seen in steatorrhea?", "Can you identify changes in the intestinal lining that might indicate altered absorption of fat and calcium, such as those seen in intestinal inflammation?", "Does the image show accumulation of unabsorbed fatty acids in the intestinal lumen, as might be found in fat digestion disorders?", "Is there a reduction in unabsorbed fatty acids in the gut, possibly following enzyme replacement therapy?", "Can you observe features that might reflect changes in the solubility or binding of fatty acids with calcium due to altered gut pH?", "Is there evidence of villous atrophy in the intestine, which could lead to increased unabsorbed fatty acids as seen in celiac disease?", "Does the image suggest reduced absorptive surface area in the intestine, as might occur after surgical resection, potentially leading to decreased formation of insoluble complexes?", "Can you identify features consistent with severe fat malabsorption and high levels of unabsorbed fatty acids in the gut, as might be seen in cystic fibrosis with pancreatic enzyme deficiency?"], "functions": ["Is there evidence of a process in the gastrointestinal tract where free fatty acids are bound to calcium ions, resulting in insoluble compounds?", "Can you identify any indication of impaired fat digestion due to the formation of insoluble complexes that prevent fatty acid absorption?", "Does the image suggest the sequestration of long-chain fatty acids within the gut, potentially limiting their uptake?", "Is there visual evidence of decreased fatty acid absorption, such as the presence of non-absorbable soaps destined for fecal excretion?", "Can you observe features that might indicate an increase in fecal fat excretion, such as signs consistent with steatorrhea?", "Is there any indication of altered mineral balance, possibly due to reduced bioavailability of dietary calcium and fatty acids?", "Does the image suggest a process that regulates lipid metabolism by limiting the intestinal absorption of dietary fats?", "Can you see signs that dietary fat bioavailability is reduced because of the formation of insoluble complexes in the gut?", "Is there evidence of a mechanism that prevents fat absorption by binding fatty acids and reducing their intestinal uptake?", "Does the image show any interaction with bile acids that could indicate competition for fatty acids, potentially disrupting micelle formation and interfering with digestion?"]}, "no_questions": {"contexual_properties": ["Can you see color changes within a lesion, such as areas of hemorrhage, necrosis, or increased vascularity?", "Does the structure display increased fibrous tissue or a desmoplastic stromal response?", "Can you observe changes in consistency or firmness of the lesion, potentially due to fibrosis, necrosis, or calcification?"], "properties": ["Is there moderate to abundant stromal tissue, possibly due to a desmoplastic reaction?", "Does the image show a region composed of gland-forming epithelial cells, fibroblasts, and inflammatory cells?", "Is there a region with a noticeably high proliferation rate compared to adjacent tissue?"], "relational": ["Can you see a region where normal tissue boundaries of glandular epithelium are disrupted or lost?", "Is there visual evidence of invasion into adjacent organs or spread to lymph nodes or distant sites?", "Does the image show a lesion affecting glandular epithelium or submucosal tissue?"], "contexual_behavior": ["Does the structure display altered metabolic activity, such as increased glycolysis, which might occur during hypoglycemia or use of alternative energy sources?", "Can you see evidence of immune evasion, such as reduced antigen presentation or increased expression of immune checkpoint molecules, especially in an immunosuppressed environment?", "Can you observe changes in the secretory profile, such as altered cytokine or growth factor secretion, in response to the tumor microenvironment?"], "functions": ["Can you see signs of inflammation or changes in the local tissue environment near the abnormal growth?", "Is there visual evidence of tissue invasion or local spread into surrounding structures?", "Is there evidence of vascular or lymphatic invasion that could indicate potential for metastatic spread?"]}}, "white chalky deposits": {"yes_questions": {"contexual_properties": ["Does the image show any areas that appear larger due to ongoing accumulation of calcium or urate salts?", "Are there multiple regions that could indicate persistent metabolic or inflammatory processes such as chronic gout or soft tissue calcification?", "Can you identify any regions where a change in color suggests secondary infection, hemorrhage, or chemical alteration?", "Is there evidence of hardening in certain areas that might result from progressive mineralization or crystal growth?", "Do any regions appear softened, possibly due to local enzymatic activity, inflammation, or medical treatment?", "Are there new locations in the image where abnormal material has appeared, suggesting disease progression or systemic metabolic imbalance?", "Can you observe a decrease in the amount of abnormal material, potentially indicating effective therapy or disease resolution?", "Are there areas that look more prominent because of thinning overlying tissues, increased inflammation, or growth of the abnormal material?", "Is there visual evidence of dissolution, such as reduction in size or disappearance of abnormal material, possibly due to chelation therapy or restored metabolic balance?", "Do you see changes in the appearance of deposits that could be attributed to shifts in calcium or uric acid levels?", "Are there signs of local inflammation or tissue injury associated with the abnormal material, suggesting immune activation or crystal-induced inflammation?", "Can you identify structures that would be visible on radiographic imaging due to sufficient size or density?", "Are there regions with irregular borders, possibly resulting from partial resorption, fragmentation, or infiltration by inflammatory cells?", "Do any areas appear denser, consistent with mineral accumulation or maturation of the abnormal material?", "Are there regions where the abnormal material is less distinct, perhaps due to partial dissolution, surrounding edema, or soft tissue reaction?"], "properties": ["Does the image show any structures that appear white in color?", "Can you identify any areas with a chalky, brittle, or powdery texture?", "Is there evidence of deposits that could be composed of minerals such as calcium phosphate or calcium carbonate?", "Are there any granular, irregular, or nodular formations visible?", "Can you see any objects that might have a crystalline or microcrystalline appearance, such as hydroxyapatite or calcite?", "Is there a structure whose density could be consistent with that of calcium salts, around 2.7 g/cm\u00b3?", "Are there deposits that might have a hardness of approximately 3\u20135 on the Mohs scale?", "Can you identify any formations that are likely to be slightly soluble or insoluble in water?", "Is there a visible deposit that could have a high calcium content, possibly exceeding 30% by weight?", "Are there any objects that might contain significant phosphorus, as would be expected if calcium phosphate is present?", "Can you see any deposits that are likely to have low to moderate magnesium content?", "Are there structures whose size ranges from micrometers to several centimeters?", "Is there evidence of masses that could weigh from milligrams to several grams?", "Do any of the visible deposits have a neutral to slightly alkaline appearance, as might be inferred from their context?"], "relational": ["Does the image show any abnormal material within joints, kidneys, skin, or heart valves?", "Can you identify any changes in tendons, subcutaneous tissue, or synovial membranes that might indicate an underlying pathological process?", "Is there evidence of involvement of the musculoskeletal, renal, integumentary, or cardiovascular systems by abnormal deposits?", "Are there visible alterations in periarticular areas, fingers, elbows, or ears that could suggest a localized pathological process?", "Can you see any clusters of cells such as macrophages, fibroblasts, lymphocytes, or giant cells near abnormal deposits?", "Is there a region where abnormal material appears to be associated with collagenous structures or the extracellular matrix?", "Are there any blood vessels, nerves, or muscle fibers adjacent to abnormal deposits in the image?", "Does the image show structural changes in organs like the kidneys, heart, skin, or joints that could be due to abnormal deposits?", "Can you identify firm nodules, areas of discoloration, or calcified masses that distinguish certain regions from the surrounding tissue?", "Is there evidence of larger pathological structures such as tophi, calcified plaques, or dystrophic calcifications that might contain abnormal deposits?"], "contexual_behavior": ["Does the image show evidence of tissue injury where abnormal mineral accumulation is present?", "Is there a region in the image that suggests dystrophic calcification in damaged or necrotic tissues?", "Can you identify any deposits that might be more prominent in the context of chronic kidney disease?", "Is there visual evidence of abnormal accumulation that could be linked to impaired phosphate excretion or secondary hyperparathyroidism?", "Does the image contain deposits that may have formed rapidly in response to elevated calcium levels?", "Can you see any abnormal mineralization in otherwise healthy tissues that could suggest metastatic calcification?", "Is there a reduction in abnormal deposits that might indicate correction of a metabolic imbalance or normalization of calcium levels?", "Does the image show any features that could impair joint function, such as accumulation of monosodium urate crystals?", "Is there evidence of joint inflammation or reduced mobility due to crystal deposition?", "Can you identify any changes that might suggest a response to medical intervention, such as therapy-induced reduction of abnormal deposits?", "Are there areas of soft tissue with increased abnormal mineralization that could be associated with metabolic disorders like hyperparathyroidism or pseudogout?", "Does the image show impaired wound healing or chronic inflammation in the skin due to abnormal mineral accumulation?", "Is there evidence of organ dysfunction or calcification that could be related to systemic diseases such as systemic sclerosis or chronic renal failure?", "Can you see more prominent abnormal deposits in regions that appear to have experienced trauma or tissue necrosis?", "Is there visual evidence of vascular dysfunction, such as stiffened vessel walls, that could be due to calcific vasculopathy?", "Are there fewer abnormal deposits in areas where dietary modification or metabolic control may have reduced serum calcium or uric acid levels?", "Does the image suggest increased abnormal mineralization in association with autoimmune conditions or connective tissue diseases?", "Is there evidence that abnormal deposits are interfering with normal enzymatic activity or disrupting the local biochemical environment in tissues?"], "functions": ["Does the image show evidence of mineral precipitation within tissues?", "Can you identify areas that might indicate dystrophic or metastatic calcification?", "Is there a region that could be causing mechanical obstruction or reduced elasticity in the tissue?", "Does the image reveal signs of cellular damage potentially linked to abnormal mineral accumulation?", "Are there features suggesting chronic inflammation or ongoing pathology in the tissue?", "Can you see any evidence of immune cell recruitment or local tissue irritation?", "Does the image display patterns consistent with macrophage activation, fibrosis, or granuloma formation?", "Is there a structure that appears to be causing obstruction or loss of compliance in an organ?", "Can you identify areas where functional decline of tissue might be occurring?", "Are there visual cues of cellular stress or impaired nutrient exchange in the affected region?", "Does the image suggest mitochondrial dysfunction or altered cellular metabolism in certain areas?", "Can you see signs of phagocytosis or an inflammatory response in the tissue?", "Is there evidence of calcium salt accumulation or matrix mineralization leading to tissue hardening?", "Does the image show features that could contribute to delayed tissue repair or persistent tissue damage?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Are there visible differences in the ribs or spine that could suggest a connective tissue disorder?", "Does the image show any abnormalities in vascular tissue that could indicate altered elasticity?", "Can you see any joint abnormalities, such as hypermobility or unusual structure in the knees, elbows, fingers, or wrists?"], "contexual_behavior": ["Is there evidence of worsened aortic dilation during pregnancy, possibly due to increased blood volume and cardiac output?", "Is there a visible indication of increased risk for aortic dissection, especially in the context of physical exertion or elevated blood pressure?", "Is there evidence of altered cardiovascular function, such as aortic dilation or dissection, in the presence of hypertension?"], "functions": ["Does the image reveal decreased elasticity or fragility in blood vessels, making them appear more susceptible to dilation or rupture?", "Can you observe signs of ocular abnormalities, such as lens displacement or indications of nearsightedness?", "Can you see abnormalities in heart valve structure or function, such as prolapse or regurgitation of the mitral valve?"]}}, "histone subunits": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a cellular compartment where chromatin is present?", "Is there a structure within the nucleus that could contain nucleosomes?", "Can you identify a region where protein complexes such as histone octamers might be assembled?", "Does the image contain evidence of chromatin structure?", "Is there a visible area where DNA might interact with protein complexes?", "Can you see any indication of macromolecular assemblies that organize into chromosomes?", "Is there a compartment where chromatin remodeling complexes or histone chaperones could be active?", "Does the image show a region likely to contain both histone and non-histone chromosomal proteins?", "Is there a structure that could be composed of repeating units fundamental to chromatin organization?", "Can you identify a cellular region where higher-order chromatin fibers might be observed?"], "contexual_behavior": [], "functions": ["Does the image show structures that are involved in organizing and stabilizing DNA within the nucleus?", "Can you identify components that form the core of nucleosomes around which DNA is wrapped?", "Is there evidence of elements essential for establishing higher-order chromatin structure?", "Does the image display features related to the assembly of nucleosomes?", "Can you see any indication of structures that undergo chemical modifications such as methylation or acetylation to regulate gene activity?", "Is there visual evidence of components involved in epigenetic regulation or transcriptional control?", "Does the image contain features that participate in DNA repair by providing recognition sites for repair proteins?", "Can you identify structures that facilitate chromatin remodeling to allow access to damaged DNA?", "Is there evidence of elements that control chromatin condensation during the cell cycle?", "Does the image show features that might be involved in chromosome segregation or chromosome dynamics?", "Can you see structures that modulate DNA accessibility for transcription by altering nucleosome positioning?", "Is there visual evidence of scaffolds around which DNA is wound for nucleosome formation?", "Does the image contain features that interact with chromatin remodeling complexes to regulate chromatin structure?", "Can you identify components that help maintain genome stability by protecting DNA from damage?", "Is there evidence of elements ensuring proper chromosome structure and genome integrity?"]}, "no_questions": {"contexual_properties": ["Can you observe variation in the number of nuclear bodies within the nucleus, possibly reflecting cell cycle progression, nucleolar fusion, or fragmentation?", "Are there nuclear bodies with increased density, possibly reflecting enhanced ribosomal biogenesis, oncogenic activity, or nucleolar stress?", "Do any nuclear features appear less visible in areas showing cellular differentiation, senescence, or after therapy response?"], "properties": ["Does the image show any round or oval structures within the nucleus that are approximately 1 to 5 micrometers in diameter?", "Do you observe distinct granular and fibrillar regions within any nuclear body?", "Is there a visible nuclear feature that could indicate a high concentration of nucleic acids, such as ribosomal RNA?"], "relational": ["Can you identify nuclear organizer regions or Cajal bodies in proximity to altered nucleoli?", "Can you identify neoplastic or tumor cells that contain distinctive nuclear features?", "Is there a relationship between the nucleus and endoplasmic reticulum or nuclear pore complex visible in cells with abnormal nucleoli?"], "contexual_behavior": ["Is there a structure that alters its function to facilitate viral replication or sequester viral proteins during viral infection?", "Does the image show a structure that increases ribosomal RNA synthesis during periods of rapid cell growth?", "Can you see changes in nucleolar structure or function in response to oxidative stress?"], "functions": ["Does the image show a nuclear structure involved in ribosome biogenesis?", "Is there evidence of a structure coordinating the maturation and modification of precursor rRNAs?", "Does the image show a nuclear component that sequesters specific proteins or RNAs, potentially modulating their nuclear availability?"]}}, "foci of fat necrosis": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show any areas that range in size from a few millimeters to several centimeters?", "Can you identify regions with an irregular or nodular shape?", "Are there any structures that appear pale yellow or chalky white in color?", "Is there a visible area that looks firm or gritty in texture?", "Can you find regions that might contain necrotic adipocytes or inflammatory cells?", "Are there areas that could include calcified material?", "Does the image show clusters of macrophages, multinucleated giant cells, or neutrophils?", "Can you identify regions with high lipid content due to the breakdown of adipose tissue?", "Are there areas where calcium concentration might be elevated, possibly due to calcification?", "Do you see any regions with reduced water content compared to normal adipose tissue?", "Is there a structure that appears denser than surrounding fat, possibly due to cellular infiltration or calcification?", "Can you spot microscopic features such as disrupted fat cells, basophilic calcium deposits, or inflammatory infiltrate?", "Are there areas that might have a slightly acidic environment due to inflammation and cellular breakdown?", "Can you identify regions with elevated protein content, possibly from inflammatory exudate or cellular debris?", "Do you see evidence of calcification occurring with moderate to high frequency, especially in chronic-appearing lesions?", "Is there a single focus or are there multiple discrete lesions present in the tissue?"], "relational": ["Does the image show any regions within adipose or subcutaneous tissue that appear abnormal?", "Can you identify any changes in breast or abdominal fat tissue that might indicate tissue injury?", "Is there evidence of lesions associated with the digestive, integumentary, or endocrine systems?", "Are there any abnormal areas adjacent to connective tissue septa or blood vessels?", "Can you see clusters of cells such as macrophages or multinucleated giant cells within fatty tissue?", "Does the image reveal regions where neutrophils or adipocytes are present in an inflammatory context?", "Is there a visible lesion in the breast, pancreas, or omentum that could indicate tissue damage?", "Are there areas surrounded by fibrous tissue, collagen fibers, or inflammatory stroma within fatty regions?", "Can you identify any abnormality near capillaries or small arteries that suggests vascular injury or inflammation?", "Is there evidence of interaction between inflammatory cells, fibroblasts, or the extracellular matrix in fatty tissue?", "Does the image contain larger lesions such as pseudocysts or masses that might include areas of tissue breakdown?", "Can you see any features consistent with saponification lesions within fatty tissue?"], "contexual_behavior": [], "functions": ["Does the image show any regions where adipocyte death or localized tissue injury is apparent?", "Can you identify areas that might be undergoing tissue remodeling due to the clearance of necrotic fat cells?", "Is there evidence of local inflammation, such as the presence of cellular debris or signs of cytokine release?", "Are there regions where immune cells like macrophages or neutrophils appear to be recruited to a site of injury?", "Does the image reveal any areas where persistent inflammation or delayed tissue regeneration is visible?", "Can you see signs of adipose tissue breakdown, such as regions suggestive of lipolysis or phagocytosis of fat cells?", "Is there evidence of inflammatory mediator release, such as cytokines or chemokines, from damaged adipocytes or infiltrating immune cells?", "Are there any indications of microvascular injury, vascular dysfunction, or thrombosis in the surrounding tissue?", "Can you identify areas where fibrosis might be developing, such as regions with increased fibroblast activity or extracellular matrix deposition?", "Is there visual evidence of macrophage interaction with necrotic material or modulation of the inflammatory response in the tissue?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an object present that typically measures between 4 and 6 centimeters in length and 2 to 3 centimeters in width?", "Can you see a structure whose tissue pH might be between 7.2 and 7.4?", "Is there a structure that could contain specialized cells such as chromaffin cells or those from the zona glomerulosa, fasciculata, or reticularis?"], "relational": ["Does the image contain an object situated near the liver or diaphragm?", "Is there evidence of a gland receiving blood from the superior, middle, or inferior suprarenal arteries?", "Can you see a structure supported by renal fascia or surrounded by perirenal fat?"], "contexual_behavior": [], "functions": ["Is there a structure that helps regulate salt and water balance by controlling sodium reabsorption and potassium excretion?", "Does the image show an object that regulates blood sugar by stimulating gluconeogenesis and inhibiting insulin action?", "Is there an anatomical feature that influences blood pressure by affecting sodium and water retention in the kidneys?"]}}, "mesentery": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a structure that is part of the digestive system and provides support to the small or large intestine?", "Can you identify a region that anchors the intestines to the posterior abdominal wall?", "Is there a visible structure through which major blood vessels, such as the superior mesenteric artery or vein, pass?", "Does the image contain a conduit for autonomic nerves, including branches of the vagus nerve or sympathetic fibers?", "Can you see lymphatic structures, such as mesenteric lymph nodes or lymphatic vessels, associated with the intestines?", "Is there a tissue layer that attaches to the jejunum, ileum, or colon?", "Does the image show layers composed of visceral peritoneum and connective tissue supporting the intestines?", "Can you identify areas containing loose areolar tissue or adipose tissue near the intestines?", "Is there a structure that serves as a pathway for blood vessels, nerves, and lymphatics to reach the intestines?"], "contexual_behavior": [], "functions": ["Is there a structure in the image that suspends the intestines and maintains their position within the abdominal cavity?", "Can you identify a connective tissue fold that attaches the intestines to the posterior abdominal wall?", "Does the image show a feature that provides both vascular and nerve supply to the intestines?", "Is there evidence of arteries, veins, or capillaries delivering blood to and from the intestines?", "Can you see a structure that contains lymphatic vessels responsible for draining lymph from the gut?", "Is there a region that appears to house lymphoid tissue or facilitate immune cell movement within the abdomen?", "Does the image include a fold of tissue that anchors abdominal organs and provides structural support?", "Can you identify an area that stores fat and may serve as an energy reserve or provide insulation?", "Is there a visible pathway for autonomic nerves that could regulate intestinal motility and secretions?", "Does the image show a feature that allows the intestines to move while preventing them from becoming entangled?", "Can you see a structure that might transport absorbed nutrients from the intestines to the portal circulation?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a muscular layer that could correspond to the tunica media of a blood vessel?", "Does the image show a tissue layer that could be part of the muscularis or tunica media?", "Can you see muscle bundles surrounded by connective tissue such as endomysium, perimysium, or collagenous stroma?"], "contexual_behavior": [], "functions": ["Does the image contain a structure that controls the flow of substances through hollow organs by altering the diameter of the lumen?", "Does the image show tissue maintaining vascular tone or contributing to blood pressure regulation?", "Does the image show a structure responsible for generating force for involuntary movements in organs?"]}}, "sites of lipid breakdown": {"yes_questions": {"contexual_properties": ["Does the image show any anatomical region where the breakdown of fats is likely to occur?", "Can you identify a structure associated with the digestion or processing of lipids?", "Is there a visible area that could participate in the chemical breakdown of dietary fats?", "Does the image contain any part of the digestive system where lipid catabolism might take place?"], "properties": ["Does the image show a region that could be part of the small intestine or stomach?", "Is there a structure present where enzymes such as pancreatic lipase or gastric lipase might be active?", "Can you identify an area where the pH is likely to be between 6 and 8 or between 3 and 6?", "Is there a region in the image that would be maintained at approximately 37\u00b0C?", "Does the image contain a location where the concentration of lipids could range from 1 to 10 g/dL after a meal?", "Can you see a structure where bile salts might be present at concentrations of 2\u201310 mM?", "Is there an area where free fatty acids could reach concentrations of 0.5\u20132 mM during digestion?", "Does the image show a region where monoglycerides might be found at 0.2\u20131 mM?", "Can you identify a location with high water content, such as 85\u201390% in chyme?", "Is there a structure composed of cells like enterocytes, goblet cells, or enteroendocrine cells?", "Does the image show a surface with extensive area, possibly due to villi and microvilli, reaching up to 200\u2013300 square meters?", "Can you identify a region where the partial pressure of oxygen is relatively low, around 30\u201340 mmHg?", "Is there a location where sodium concentration is about 140\u2013145 mM?", "Does the image contain a region where potassium concentration could be 5\u201315 mM?", "Can you see an area where calcium concentration might be 1\u20132 mM?"], "relational": ["Does the image show a region that is part of the digestive or lymphatic system where lipid processing might occur?", "Can you identify an organ such as the stomach, small intestine, or pancreas that could be involved in lipid breakdown?", "Is there visible tissue that could correspond to intestinal mucosa, pancreatic tissue, or gastric mucosa?", "Does the image contain anatomical regions like the duodenum, jejunum, or gastric antrum?", "Can you see cellular structures such as enterocytes, pancreatic acinar cells, or gastric chief cells?", "Is there evidence of ducts or vessels like the pancreatic duct, common bile duct, or lymphatic capillaries connected to regions of digestion?", "Does the image include organs such as the liver, gallbladder, or pancreas that interact with digestive processes?", "Can you identify a structure that is functionally or spatially integrated within the gastrointestinal tract?", "Is there a visible pathway or structure that could deliver lipids, such as chyme, bile ducts, or chylomicrons, to a digestive compartment?", "Does the image show compartments of the digestive system, such as the stomach, duodenum, or jejunum, that might participate in lipid breakdown?"], "contexual_behavior": ["Does the image show a structure whose activity increases during fasting, possibly due to hormone-sensitive lipase activation?", "Can you identify a region that would reduce its function in the presence of metabolic disorders such as type 2 diabetes?", "Is there a structure that accelerates lipid hydrolysis during exercise as a result of increased catecholamine levels?", "Does the image contain an area that might show impaired function in obesity due to chronic inflammation?", "Can you see a structure that would increase its activity in response to a high-fat diet through upregulation of lipolytic enzymes?", "Is there a region where lipid processing would decrease during insulin resistance because of impaired suppression of lipolysis?", "Does the image include a structure that enhances triglyceride breakdown during stress, possibly influenced by elevated cortisol?", "Can you identify an area that fails to mobilize fatty acids in cases of hormonal imbalance such as hypothyroidism?", "Is there a structure whose activity would be reduced in hypothermia due to decreased enzymatic activity?", "Does the image show a region that increases lipolysis during prolonged starvation to provide energy for vital organs?", "Can you see a structure that might have altered function in the context of liver disease due to disrupted lipid metabolism?", "Is there an area where efficiency decreases with aging as a result of changes in adipose tissue function?", "Does the image contain a region that increases fatty acid release during acute illness because of inflammatory cytokines?", "Can you identify a structure that reduces its role in lipid metabolism after feeding due to increased insulin levels?", "Is there an area that becomes hyperactive in certain endocrine disorders such as Cushing's syndrome due to excessive hormone stimulation?"], "functions": ["Does the image show a location where triglycerides are hydrolyzed into absorbable molecules?", "Is there a structure present that facilitates fat digestion through enzyme activity or emulsification?", "Can you identify an area where lipase activity or bile action might be occurring?", "Does the image include a region involved in the release of fatty acids for energy production?", "Is there evidence of a process that generates ATP from fatty acid oxidation?", "Can you see a site where dietary fats are converted into micelles for absorption?", "Is there a structure that could facilitate the uptake of fatty acids across enterocyte membranes?", "Does the image contain a region that regulates the rate or extent of lipid catabolism?", "Is there a visible feature associated with the enzymatic cleavage of dietary fats into monoglycerides and free fatty acids?", "Can you identify an area involved in the mobilization of stored lipids, such as the activation of lipases in adipose tissue?", "Does the image show a location where ketone bodies might be generated from fatty acids?", "Is there a structure that could be involved in the production of acetyl-CoA for ketogenesis?", "Can you see a region that participates in the release and transport of cholesterol from dietary or stored lipids?", "Is there evidence of a process supporting steroid hormone production through the provision of lipid-derived precursors?"]}, "no_questions": {"contexual_properties": ["Is there a firm, nodular mass visible that could be palpable due to fibrosis and calcification?", "Can you see areas with hemorrhagic changes, such as localized bleeding, possibly due to vascular injury during necrosis?", "Can you identify chalky deposits that may result from saponification and calcium soap formation?"], "properties": ["Can you identify a region with lower water content compared to normal adipose tissue?", "Is there an area that appears to have a normal temperature, unless there are signs of localized warmth from inflammation?", "Is there an area where inflammatory cells make up a significant portion of the tissue?"], "relational": ["Are there visual signs of scar formation or connective tissue proliferation in areas where fat is normally present?", "Does the image display areas of tissue surrounded by fibrous tissue or infiltrated by inflammatory cells?", "Does the image show changes in tissues that could impact the integumentary, digestive, or endocrine systems?"], "contexual_behavior": ["Is there evidence of disrupted hormone signaling in adipose tissue, such as altered adipokine activity or inflammation?", "Can you see evidence that the protective cushioning role of fat pads is compromised due to loss of shock-absorbing properties?", "Are there signs of disrupted fat absorption in the vicinity of pancreatic injury, such as digested peripancreatic fat?"], "functions": ["Can you see signs of fibrosis or increased collagen deposition indicating tissue remodeling?", "Does the image show evidence of a process involving enzymatic breakdown of lipids and inflammation?", "Is there visual evidence of free fatty acid release or the formation of fatty acid-calcium complexes, such as saponification?"]}}}
|
|
[
{
"answer": "yes",
"extracted_concepts": [
"lower-extremity deep venous thrombus",
"embolus",
"pulmonary artery branch"
],
"question": "is embolus derived from a lower-extremity deep venous thrombus lodged in a pulmonary artery branch?"
},
{
"answer": "no",
"extracted_concepts": [
"pulmonary artery branch",
"edema"
],
"question": "is edema lodged in a pulmonary artery branch?"
},
{
"answer": "embolus",
"extracted_concepts": [
"pulmonary artery branch",
"embolus"
],
"question": "what is lodged in a pulmonary artery branch?"
}
] |
["lower-extremity deep venous thrombus", "embolus", "edema", "pulmonary artery branch"]
|
{"lower-extremity deep venous thrombus": {"yes_questions": {"contexual_properties": ["Does the image show evidence of a structure within a deep vein that appears enlarged, suggesting ongoing coagulation or propagation?", "Can you identify a feature that appears reduced in size, possibly indicating the effects of anticoagulation therapy or endogenous fibrinolysis?", "Is there a structure that appears more organized or fibrotic, consistent with fibroblast infiltration and collagen deposition over time?", "Does the image reveal a less organized or loosely structured area, which could correspond to early formation or active fibrinolysis?", "Can you observe a change in composition, such as a transition from a fibrin-rich to a collagen-rich appearance, indicating maturation or chronicity?", "Is there evidence of calcification within a venous structure, suggesting dystrophic changes in a chronic lesion?", "Does the image show a structure that appears more mobile or loosely attached to the vessel wall, raising concern for embolization risk?", "Can you see a region that is firmly adherent to the vessel wall, possibly due to organization and endothelialization?", "Is there an area within a deep vein that demonstrates increased echogenicity on ultrasound imaging, consistent with organization and fibrosis?", "Does the image display a hypoechoic region within a vein, which could indicate a newly formed, less organized clot?", "Can you observe a color change within a venous structure, such as a shift from red to pale or yellow, reflecting hemoglobin breakdown and fibrosis?", "Is there evidence of fragmentation or small pieces within a venous structure, possibly resulting from mechanical disruption, thrombolytic therapy, or spontaneous embolization?", "Does the image reveal new layers or stratification on the surface of an existing clot, suggesting recurrent thrombosis?", "Can you identify signs of recanalization, such as new vascular channels forming within a venous lesion during the healing process?", "Is there a difference in consistency, with some areas appearing softer or firmer, which could indicate the age of the lesion due to fibrosis?", "Does the structure within the deep vein appear to extend proximally or distally, suggesting propagation or thrombus extension?", "Can you see a decrease in density within a venous lesion, possibly due to lysis or partial resolution?", "Is there evidence of complete venous lumen obstruction, indicating that the structure has become more occlusive?", "Does the image show features such as organization, recanalization, or calcification that would indicate chronicity of a venous lesion?", "Can you observe surface irregularities or changes on a venous structure, possibly due to organization, recanalization, or partial lysis?"], "properties": ["Does the image show an elongated structure conforming to the lumen of a deep vein in the calf, femoral, or popliteal region?", "Is there an intraluminal object present in the deep veins of the lower limb that appears red or dark red in color?", "Can you identify a structure within a deep vein whose size ranges from a few millimeters to several centimeters in diameter?", "Is there an object in the deep veins that could have a length extending from a few centimeters to over 20 centimeters?", "Does the image contain a structure that appears soft and gelatinous, or possibly firmer if more organized, within a deep vein?", "Is there evidence of a mass in a deep vein that is likely composed primarily of fibrin and red blood cells?", "Can you see a structure in the deep veins that would have a density similar to blood, approximately 1.05\u20131.10 g/cm\u00b3?", "Is there a visible object in a deep vein that could have a high water content, around 70\u201380% by weight?", "Does the image show a structure in a deep vein that might have low elasticity, especially if it appears more organized?", "Is there a mass within a deep vein that could have a high protein content due to the presence of fibrin and plasma proteins?", "Can you identify an intravascular structure in the lower limb that may have low to moderate white blood cell content, particularly if it appears to be in an early stage?", "Is there a structure in a deep vein that might show signs of increased organization, suggesting it has been present for some time?", "Does the image reveal a mass in a deep vein that could have minimal cholesterol content?", "Is there an object in a deep vein that might show low calcium content, unless it appears chronic and possibly calcified?", "Can you see a structure in a deep vein that would have moderate platelet content, contributing to its stability?"], "relational": ["Does the image show evidence of an obstruction within the deep venous system of the lower limb?", "Can you identify a structure located in the thigh, calf, or popliteal fossa that appears abnormal?", "Is there a visible abnormality within the femoral, popliteal, iliac, or tibial veins?", "Does the image contain a finding that could affect the systemic venous circulation?", "Can you see any changes adjacent to skeletal muscle or subcutaneous tissue that might indicate a vascular issue?", "Is there a structure that could pose a risk to the pulmonary arteries or lungs if material were to migrate from it?", "Does the image show an abnormality within the boundaries of fascia, venous walls, or muscular compartments of the leg?", "Can you identify a finding in the lower limb that could impact the cardiovascular or pulmonary systems?", "Is there evidence of a process involving perforating veins, superficial veins, or the inferior vena cava in the lower extremity?", "Does the image reveal a potential obstruction in a vein that is surrounded by connective tissue or nerves?"], "contexual_behavior": ["Is there evidence of a structure within a major vein, such as the femoral or iliac, that appears large or causes significant blockage of blood flow?", "Can you identify a region where venous return might be severely impaired due to a sizable or occlusive formation?", "Does the image show a feature that could be loosely attached or appear fresh, potentially increasing the risk of embolization?", "Is there a visible extension of a structure into the proximal deep veins that might suggest increased embolic risk?", "Can you see signs of complete blockage within a vein, or an extensive area of clot burden that could obstruct blood flow?", "Are there visual indicators of local inflammation, such as endothelial activation or leukocyte accumulation, suggesting an acute process?", "Does the image suggest impaired oxygen delivery to tissues, possibly due to significant venous outflow obstruction or elevated venous pressure?", "Is there evidence of swelling or congestion in the lower limb that could be associated with prolonged immobility and venous stasis?", "Can you identify features that might indicate heightened procoagulant activity, possibly in the context of infection or inflammation?", "Are there signs of persistent inflammation or endothelial dysfunction that could be related to a chronic disease process?", "Does the image suggest that a clot is less stable or more prone to dissolution, potentially as a result of anticoagulant therapy?", "Is there evidence that a structure within a vein is more likely to fragment, possibly due to increased venous flow or mechanical stress from physical activity?", "Can you observe a reduction in clot size that might be attributable to thrombolytic treatment or fibrinolysis?", "Is there visual evidence of increased venous pressure in the leg, such as distended veins or swelling, that could result from major vein obstruction?", "Are there features suggesting that a clot has failed to resolve, possibly in the context of a clotting disorder or impaired fibrinolysis?", "Does the image indicate tissue hypoxia or exacerbated venous congestion, especially in the setting of heart failure?", "Is there evidence of impaired lymphatic drainage in the limb, such as chronic swelling, that could be secondary to venous hypertension?", "Can you identify signs of vein damage or incomplete clot resolution that might increase the risk of post-thrombotic syndrome?", "Are there visual clues that suggest altered clot behavior in response to hormonal changes, such as those occurring during pregnancy?", "Does the image show reduced signs of inflammation, possibly following anti-inflammatory treatment?", "Is there evidence of persistent venous obstruction or valve damage that could contribute to chronic venous insufficiency?", "Can you see features that might indicate an increased risk of recurrent thrombosis after surgery, such as signs of immobility or hypercoagulability?"], "functions": ["Does the image show evidence of venous obstruction or reduced blood flow in a deep vein of the lower limb?", "Can you identify any signs of increased venous pressure or stasis in the lower extremity?", "Is there a visible indication of impaired venous return, such as a blockage within a deep vein?", "Does the image suggest local inflammation, possibly due to endothelial activation or cytokine release?", "Can you see any features that might indicate a risk of thrombus fragments migrating toward the pulmonary circulation?", "Is there evidence of compromised tissue oxygenation, such as signs of local hypoxia or venous congestion?", "Does the image reveal swelling of the limb that could be attributed to increased hydrostatic pressure or fluid accumulation?", "Can you identify any features suggesting activation of the coagulation cascade, such as thrombin generation or platelet aggregation within a vessel?", "Is there any indication of venous valve dysfunction, such as valve incompetence or reflux in the deep veins?", "Does the image show signs of reduced limb mobility, pain, or swelling that might be related to a vascular abnormality?", "Are there chronic changes present, such as persistent edema or skin alterations, that could be associated with chronic venous insufficiency?"]}, "no_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image display any relationship between the coronary arteries and larger cardiovascular structures like the aorta, left ventricle, or right atrium?", "Are there features present that indicate the cardiovascular system is primarily affected?", "Are there signs of affected regions within the myocardium, such as the left ventricular wall or interventricular septum?"], "contexual_behavior": [], "functions": ["Is there evidence of myocardial infarction, such as localized tissue damage or scarring in the heart?", "Does the image reveal any signs of plaque rupture or thrombotic events within the coronary arteries?", "Are there visual cues suggesting transient ischemia or regions that could be associated with angina pectoris?"]}}, "embolus": {"yes_questions": {"contexual_properties": [], "properties": ["Is there an object in the image whose size could range from a few micrometers to several centimeters?", "Can you identify a structure that appears irregular, spherical, elongated, or fragmented in shape?", "Does the image show a mass that could be composed of blood clot, fat, air, tumor cells, or foreign material?", "Is there a structure whose density might vary depending on whether it is blood-like or fat-like?", "Can you see an object that appears red, dark, pale, or yellowish in color?", "Is there a mass that looks soft and gelatinous, or alternatively firm and friable, suggesting different ages or stages of organization?", "Does the image contain an object whose mass could vary greatly depending on its size and composition?", "Can you identify a structure that might be made up of fibrin, platelets, fat droplets, air bubbles, tumor fragments, or amniotic fluid?", "Is there a mass that could have high water content if recent, or lower water content if composed of fat or calcified material?", "Does the image show an object that might have elevated cholesterol content, as seen in atheromatous or fat-based material?", "Can you see a structure that could contain significant protein, such as fibrin or plasma proteins?", "Is there a mass that might have high lipid content, as would be expected in fat-based or atheromatous material?", "Does the image contain a structure with increased calcium content, suggesting calcification or chronic organization?", "Can you identify an object whose consistency ranges from soft and pliable to firm and brittle?", "Is there a mass with a surface that appears smooth, rough, or irregular depending on its formation?"], "relational": ["Is there evidence of a foreign object or material moving within the circulatory system in the image?", "Does the image show an obstruction within a blood vessel such as an artery, vein, or capillary?", "Can you identify a blockage that could affect the lungs, brain, heart, or kidneys?", "Is there a structure in the image that could be causing impaired blood flow to cardiac, pulmonary, cerebral, or renal tissue?", "Does the image reveal a blockage in an arteriole or venule?", "Is there a visible object that appears to be transported by or lodged within a vein or artery?", "Can you see any evidence of a blockage in the pulmonary or cerebral circulation, or in the peripheral limbs?", "Does the image suggest that a structure originating from a heart chamber, deep vein, atherosclerotic plaque, or infected valve has traveled to another location?", "Is there a sign of a material that could have originated from the heart and is now causing a blockage elsewhere in the circulatory system?"], "contexual_behavior": [], "functions": ["Is there evidence in the image of an agent within a blood vessel that could obstruct circulation?", "Can you identify a structure that appears to be physically blocking the lumen of a vessel, potentially disrupting blood flow?", "Does the image show a feature that could cause vascular occlusion and reduce downstream perfusion?", "Is there a visible sign of tissue ischemia, such as pallor or discoloration, that might result from impaired blood supply?", "Can you see any indication of hypoperfusion or oxygen deprivation in tissues adjacent to a blocked vessel?", "Is there evidence of inflammation or endothelial activation near a vessel obstruction?", "Does the image suggest tissue necrosis or infarction in an area supplied by a blocked vessel?", "Can you observe any signs of organ dysfunction or ischemic injury that could be linked to impaired perfusion?", "Is there a disruption in nutrient delivery, waste removal, or cellular respiration in tissues downstream of a vascular blockage?", "Does the image show features suggestive of secondary clot formation or activation of the coagulation system near a vessel obstruction?"]}, "no_questions": {"contexual_properties": ["Does the neck appear thickened, possibly as a response to chronic lymphedema or fibrotic remodeling?", "Does the neck appear edematous, suggesting lymphatic obstruction or ongoing inflammatory processes?", "Is there visible pigmentation change on the neck that could be caused by chronic irritation, sun exposure, or dermatological conditions?"], "properties": ["Is the water content of the skin in the neck region consistent with normal physiological levels?", "Can you estimate if the distance from the mastoid process to the acromion exceeds 10 centimeters?", "Is there evidence of excess or overlapping skin folds along the side of the neck?"], "relational": ["Are the superficial or posterior cervical lymph nodes visible or displaced in the neck?", "Can you see any changes in the skin or subcutaneous connective tissue along the lateral neck?", "Is there evidence of pterygium colli present in the lateral or posterior neck?"], "contexual_behavior": ["Does the image show tissue redundancy in the neck that could impinge on the pharynx or esophagus, possibly contributing to swallowing difficulties under stress?", "Can you see thickened tissue in the neck that could compress superficial veins or arteries and potentially alter blood flow during exercise?", "Can you identify a neck structure where redundant skin or tissue could compress lymphatic vessels and potentially reduce lymphatic drainage in certain postures?"], "functions": ["Can you observe features that might indicate impaired lymphatic drainage, such as localized swelling suggestive of lymphedema?", "Is there any indication of mild compromise to airway patency, without evidence of significant obstruction?", "Does the image suggest possible interference with swallowing or speech due to tissue impingement on pharyngeal or laryngeal structures?"]}}, "edema": {"yes_questions": {"contexual_properties": [], "properties": ["Does the image show a region where tissue appears swollen due to increased fluid volume?", "Can you identify an area that might contain fluid with a clear or pale yellow appearance?", "Is there evidence of swelling in a dependent area, such as the lower limbs or sacral region?", "Does the image suggest the presence of tissue with increased water content, possibly exceeding 80% of its weight?", "Can you see a region where the fluid accumulation could range from several hundred milliliters to several liters?", "Is there an area that might contain fluid with a composition similar to plasma, including water, electrolytes, and protein?", "Does the image show swelling that could be due to fluid with a sodium concentration similar to plasma (approximately 135\u2013145 mmol/L)?", "Can you identify a region where the fluid might have a protein content consistent with either transudate (less than 3 g/dL) or exudate (greater than 3 g/dL)?", "Is there evidence of swelling where the fluid could have a specific gravity less than 1.015 or greater than 1.015, suggesting transudate or exudate?", "Does the image suggest the presence of fluid with a neutral to slightly alkaline pH, around 7.4?", "Can you see an area where the fluid's osmolarity might be similar to plasma, about 275\u2013295 mOsm/kg?", "Is there swelling in a region where the chloride concentration of the fluid could be close to plasma levels (around 98\u2013106 mmol/L)?", "Does the image show tissue that might contain fluid with a glucose concentration similar to plasma (approximately 70\u2013100 mg/dL)?", "Can you identify an area where the temperature of the accumulated fluid would likely reflect body temperature (36\u201337\u00b0C)?", "Is there a region where the clarity of the fluid could help distinguish between transudate (clear, non-turbid) and exudate (cloudy)?", "Does the image suggest a rate of fluid accumulation that could vary from several milliliters to liters per day depending on the underlying cause?"], "relational": ["Does the image show abnormal fluid accumulation in subcutaneous tissue or mucous membranes?", "Can you identify swelling in regions such as the lower limbs, ankles, or periorbital area?", "Is there evidence of fluid buildup in interstitial tissue or body compartments like the pleural or peritoneal cavity?", "Does the image display changes in organs such as the lungs, brain, liver, or kidneys that could indicate structural impact from excess fluid?", "Can you see signs of impaired lymphatic drainage, such as distended lymphatic vessels or lymph nodes?", "Is there visible swelling that could be related to lymphatic vessel dysfunction or obstruction?", "Does the image reveal features of the cardiovascular, renal, or lymphatic systems that might be involved in abnormal fluid retention?", "Are there indications of fluid accumulation in loose connective tissue or areolar tissue?", "Can you observe any alterations in capillaries, venules, or veins that might contribute to fluid leakage?", "Is there evidence of disruption to anatomical barriers like capillary endothelium or basement membrane that could affect fluid movement?"], "contexual_behavior": [], "functions": ["Does the image show evidence of tissue swelling that could indicate increased interstitial pressure?", "Can you identify an area where excess accumulation of interstitial fluid might be present?", "Is there a region where tissue fluid balance appears disrupted, possibly due to reduced fluid reabsorption?", "Does the image display localized swelling that could be associated with increased vascular permeability?", "Can you see signs of impaired organ function that might result from altered tissue architecture or increased pressure?", "Is there visual evidence suggesting that nutrient or oxygen delivery to tissues could be compromised, such as compressed capillaries or increased diffusion distance?", "Does the image show features that might indicate overloading or obstruction of lymphatic vessels, suggesting hindered lymphatic drainage?", "Can you identify areas where wound healing appears delayed, possibly due to increased infection risk or disrupted tissue repair?", "Is there a region where cellular signaling could be altered, such as changes in tissue structure that might affect cytokine gradients?", "Does the image reveal signs of chronic inflammation or tissue damage that could facilitate fibrosis?", "Can you see indications that metabolic waste removal from tissues might be impaired, such as slowed interstitial fluid flow or compromised venous and lymphatic clearance?"]}, "no_questions": {"contexual_properties": ["Is there a visible organ that is anatomically situated contralateral to another ovary in the image?", "Can you identify a structure that mirrors the position of an ovary on the other side of the body?", "Does the image show a paired structure located opposite to another similar organ?"], "properties": ["Is there an object whose estimated weight could be between 5 and 8 grams?", "Can you see an object that might contain between 5 and 10 antral follicles?", "Can you see a structure whose volume might range from 3 to 8 milliliters?"], "relational": ["Can you see an object situated near the fallopian tube, uterus, pelvic wall, or broad ligament?", "Can you identify a structure that is anatomically connected to the fallopian tube, potentially facilitating oocyte transport?", "Does the image contain a structure that is contralateral to another similar organ, indicating it is on the opposite side?"], "contexual_behavior": ["Can you identify an organ that is typically paired and may be located contralaterally to the main focus of the image?", "Does the image show a counterpart structure on the other side of the body relative to the main organ of interest?", "Is there evidence of a bilateral organ arrangement, with one member visible on the side opposite the primary structure?"], "functions": ["Does the image show a structure involved in oocyte production and hormone secretion?", "Does the image show an organ that interacts with the endocrine system to regulate reproductive processes?", "Can you see a structure nurturing primordial follicles through maturation stages?"]}}, "pulmonary artery branch": {"yes_questions": {"contexual_properties": [], "properties": [], "relational": ["Does the image show a vessel that is part of the cardiovascular system and involved in pulmonary circulation?", "Can you identify a structure that originates from the pulmonary trunk or pulmonary artery?", "Is there a vessel supplying blood to lobar or bronchopulmonary segments of the lung?", "Does the image contain a structure directly connected to smaller arterial branches or capillary beds?", "Can you see a vessel that delivers blood to pulmonary alveoli or lung parenchyma?", "Is there a distal subdivision of the pulmonary trunk visible in the image?", "Does the image show vessels that branch into segmental pulmonary arteries or arterioles?", "Can you identify a structure adjacent to bronchi, pulmonary veins, or lung parenchyma?", "Is there a vessel present that is part of the pulmonary circulation within the circulatory system?", "Does the image include veins associated with regions supplied by a pulmonary arterial vessel, such as pulmonary veins?"], "contexual_behavior": ["Is there a vessel in the image that would show reduced blood flow in the presence of a pulmonary embolism?", "Can you identify a structure that would deliver more blood to the lungs during exercise due to increased cardiac output?", "Does the image show a vessel that might experience reduced oxygen delivery in pulmonary hypertension?", "Is there evidence of a vascular structure that could be obstructed by a thrombus or embolus, leading to inefficient blood transport?", "Can you see a vessel that would constrict in response to low oxygen levels through hypoxic vasoconstriction?", "Is there a structure that could dilate during chronic hypoxia or after prolonged exposure to low oxygen?", "Does the image contain a vessel that might show impaired blood flow in the context of chronic lung disease due to vascular remodeling?", "Is there a structure that would have increased pressure in cases of left heart failure because of backward transmission of elevated venous pressure?", "Can you identify a vessel that would show decreased perfusion after a vascular blockage such as a pulmonary embolism?", "Is there a vascular structure that could exhibit increased permeability and altered tone during acute respiratory distress syndrome?", "Does the image show a vessel that would reduce blood supply during severe dehydration due to hypovolemia?", "Is there a structure that would increase resistance in response to inflammation through endothelial dysfunction?", "Can you see a vessel that might fail to adapt during high altitude exposure if hypoxic vasoconstriction is excessive?", "Is there evidence of a vascular structure that could show abnormal flow patterns due to congenital heart disease or structural defects?", "Does the image contain a vessel that would increase its contribution to gas exchange during physical activity by recruiting additional capillaries?"], "functions": ["Does the image show a vessel responsible for transporting blood from the heart to the lungs for gas exchange?", "Can you identify a structure that distributes blood throughout the lung parenchyma to ensure efficient perfusion of the alveoli?", "Is there a vessel present that delivers blood to the pulmonary capillaries for oxygenation?", "Does the image contain a structure that carries deoxygenated blood from the right ventricle directly to lung tissue?", "Can you see a vessel that supplies blood to alveolar capillaries, enabling gas exchange?", "Is there a structure involved in transporting blood to the lungs for carbon dioxide removal?", "Does the image show a vessel that regulates blood flow within the lungs by adjusting vascular resistance?", "Can you identify a structure that contributes to maintaining pulmonary blood pressure by modulating vessel tone?", "Is there evidence of a vessel that branches extensively to ensure even distribution of blood to different lung regions?"]}, "no_questions": {"contexual_properties": [], "properties": ["Is there an ovoid or lentiform collection within the muscle visible in the image?", "Does the image contain an area with a density between 50 and 80 Hounsfield units on CT?", "Can you identify a localized area within the temporal muscle or adjacent fascia that appears hyperdense or bright on CT?"], "relational": ["Is there involvement of fascia, such as the temporal fascia or deep temporal fascia, in the observed abnormality?", "Does the image reveal changes within skeletal muscle tissue, subcutaneous tissue, or periosteum in the temporal area?", "Is there evidence of risk or involvement of cranial nerves near the temporal region?"], "contexual_behavior": ["Can you see indications of metabolic dysfunction in the muscle, such as signs of ischemia or impaired nutrient delivery?", "Does the image reveal a hematoma or tissue damage that could increase the risk of secondary infection in the temporal region?", "Can you identify features that might indicate decreased neuromuscular coordination due to pain, inflammation, or structural disruption?"], "functions": ["Does the image reveal tissue changes that could activate nociceptors or cause local irritation?", "Does the image suggest weakness or dysfunction in a muscle involved in mastication, potentially leading to painful chewing?", "Is there evidence of mechanical obstruction or swelling that could interfere with the function of nearby tissues?"]}}}
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[{"answer":"by nests of closely packed glands","extracted_concepts":["hyperplasia without atypia","n(...TRUNCATED)
| "[\"endoscopic view\", \"longitudinally-oriented mallory-weiss\", \"hyperplasia without atypia\", \"(...TRUNCATED)
| "{\"endoscopic view\": {\"yes_questions\": {\"contexual_properties\": [\"Is there evidence of mucosa(...TRUNCATED)
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[{"answer":"no","extracted_concepts":["palmar creases"],"question":"is normal palmar creases present(...TRUNCATED)
| "[\"palmar creases\", \"esophagus\", \"acrocyanosis\", \"gastrointestinal\", \"gastrointestinal syst(...TRUNCATED)
| "{\"palmar creases\": {\"yes_questions\": {\"contexual_properties\": [\"Does the image show lines on(...TRUNCATED)
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[{"answer":"excellent photo typical adenocarcinoma extending through muscularis to serosa","extracte(...TRUNCATED)
| "[\"muscularis\", \"edema\", \"typical tuberculous exudate\", \"mucoepidermoid carcinoma\", \"adenoc(...TRUNCATED)
| "{\"muscularis\": {\"yes_questions\": {\"contexual_properties\": [], \"properties\": [\"Does the ima(...TRUNCATED)
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[{"answer":"typical infiltrating adenocarcinoma","extracted_concepts":["typical infiltrating adenoca(...TRUNCATED)
| "[\"adrenal\", \"pulmonary artery\", \"retroperitoneal\", \"retroperitoneal leiomyosarcoma\", \"aden(...TRUNCATED)
| "{\"adrenal\": {\"yes_questions\": {\"contexual_properties\": [], \"properties\": [\"Does the image (...TRUNCATED)
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[{"answer":"typical histology for colon adenocarcinoma","extracted_concepts":["colon adenocarcinoma"(...TRUNCATED)
| "[\"amyloid angiopathy\", \"gastrointestinal system\", \"endocrine\", \"colon\", \"gastrointestinal\(...TRUNCATED)
| "{\"amyloid angiopathy\": {\"yes_questions\": {\"contexual_properties\": [\"Does the image show bloo(...TRUNCATED)
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[{"answer":"hyperplasia without atypia","extracted_concepts":["cellular atypia","glandular crowding"(...TRUNCATED)
| "[\"cellular atypia\", \"inclusion-like nucleoli\", \"hyperplasia without atypia\", \"hyperplasia wi(...TRUNCATED)
| "{\"cellular atypia\": {\"yes_questions\": {\"contexual_properties\": [\"Does the image show feature(...TRUNCATED)
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[{"answer":"typical excellent pinworm","extracted_concepts":["pinworm"],"question":"what does this i(...TRUNCATED)
| "[\"acid\", \"carcinoma metastatic lung\", \"myocardium\", \"normal ovary\", \"gastrointestinal\", \(...TRUNCATED)
| "{\"acid\": {\"yes_questions\": {\"contexual_properties\": [\"Does the image show a solution whose c(...TRUNCATED)
|
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