text stringlengths 569 35.8k | metadata stringlengths 465 8.13k |
|---|---|
Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions*
Previous studies have shown that extracellular signal-regulated kinase 1/2 (ERK1/2) directly inhibits mitochondrial function during cellular i... | [{"added": "2018-04-03T05:55:04.429Z", "created": "2016-11-14T00:00:00.000", "id": "205361901", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/291/52/26850.full.pdf", "pdf_hash": "cf2aa24bad6550f11b5881747113c6ed002170d0", "pd... |
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. For example pri-miR-142, expressed in hematopoietic cells is edited by ADAR1p110 and ADAR2 ... | [{"added": "2017-05-09T16:41:51.382Z", "created": "2015-09-30T00:00:00.000", "id": "11272155", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://www.mdpi.com/2218-273X/5/4/2338/pdf", "pdf_hash": "019a9293cf4d9113faa648b5717abf464f06a129", "pdf_src": ... |
Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain*
Herpes simplex virus entry into cells requires a multipartite fusion apparatus made of glycoprotein D (gD), gB, and heterodimer gH/gL. 5C, lane 1 contains lysates from 0.2 ϫ 10 2 PFUs. T... | [{"added": "2018-04-03T05:51:57.558Z", "created": "2009-04-22T00:00:00.000", "id": "22331065", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/26/17370.full.pdf", "pdf_hash": "4e8f64911e20eded6ecd92165c472e469686875d", "pdf... |
@@@ Q: Given-
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
Background EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. Re... | [{"added": "2016-05-17T03:20:48.815Z", "created": "2015-02-06T00:00:00.000", "id": "8037534", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/s12860-015-0047-7", "pdf_hash": "ff85844cfe70d09cad452e998... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. Only genes affected by maternal ICRs were significantly overrepresented in functional categories related to placentation and mother-to-embryo exchanges. In contrast, the effect... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice
Background A sedentary lifestyle and poor diet are risk factors for the progression of non-alcoholic fatty liver disease. Each value is the mean ± SEM (n = 6), and any two groups without the same lowercase or ... | [{"added": "2017-08-03T02:00:53.866Z", "created": "2017-03-29T00:00:00.000", "id": "6263760", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-017-0461-2", "pdf_hash": "426f645e7c804ff66391919785... |
Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex
The majority of the polytopic proteins that are synthesized at the ER (endoplasmic reticulum) are integrated co-translationally via the Sec61 translocon, which provides lateral access for their hydrophobic TMs (t... | [{"added": "2017-11-13T05:37:00.817Z", "created": "2013-09-10T00:00:00.000", "id": "16601343", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.biochemj.org/content/456/2/297.full.pdf", "pdf_hash": "29dfab08cd3fb87d7a96fadd33cf10054a7e5664", "p... |
Effect of Negative Pressure on Proliferation, Virulence Factor Secretion, Biofilm Formation, and Virulence-Regulated Gene Expression of Pseudomonas aeruginosa In Vitro Objective. Colony diameter and growth curve indicated that negative pressure conditions could significantly inhibit the proliferation and growth rate o... | [{"added": "2018-04-03T01:10:36.741Z", "created": "2016-12-15T00:00:00.000", "id": "17029880", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://doi.org/10.1155/2016/7986234", "pdf_hash": "cbba8e5ac72f874376623b4dd75b65a0b20c8f4b", "pdf_src": "PubMed... |
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. In grey is shown where the deaminase domain is likely positioning during the reaction. PDB ... | [{"added": "2017-05-09T16:41:51.382Z", "created": "2015-09-30T00:00:00.000", "id": "11272155", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://www.mdpi.com/2218-273X/5/4/2338/pdf", "pdf_hash": "019a9293cf4d9113faa648b5717abf464f06a129", "pdf_src": ... |
Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice
Background A sedentary lifestyle and poor diet are risk factors for the progression of non-alcoholic fatty liver disease. Meanwhile, all n-3 supplementation groups showed attenuation of body weight gain compar... | [{"added": "2017-08-03T02:00:53.866Z", "created": "2017-03-29T00:00:00.000", "id": "6263760", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-017-0461-2", "pdf_hash": "426f645e7c804ff66391919785... |
Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex
The majority of the polytopic proteins that are synthesized at the ER (endoplasmic reticulum) are integrated co-translationally via the Sec61 translocon, which provides lateral access for their hydrophobic TMs (t... | [{"added": "2017-11-13T05:37:00.817Z", "created": "2013-09-10T00:00:00.000", "id": "16601343", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.biochemj.org/content/456/2/297.full.pdf", "pdf_hash": "29dfab08cd3fb87d7a96fadd33cf10054a7e5664", "p... |
Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain*
Herpes simplex virus entry into cells requires a multipartite fusion apparatus made of glycoprotein D (gD), gB, and heterodimer gH/gL. In this assay, progeny virus harvested at 18 h afte... | [{"added": "2018-04-03T05:51:57.558Z", "created": "2009-04-22T00:00:00.000", "id": "22331065", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/26/17370.full.pdf", "pdf_hash": "4e8f64911e20eded6ecd92165c472e469686875d", "pdf... |
Effect of Negative Pressure on Proliferation, Virulence Factor Secretion, Biofilm Formation, and Virulence-Regulated Gene Expression of Pseudomonas aeruginosa In Vitro Objective. aeruginosa was grown overnight and cultured in Luria broth at 37 ∘ C until log-phase was achieved. Optical density at 600 nm wavelength was m... | [{"added": "2018-04-03T01:10:36.741Z", "created": "2016-12-15T00:00:00.000", "id": "17029880", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://doi.org/10.1155/2016/7986234", "pdf_hash": "cbba8e5ac72f874376623b4dd75b65a0b20c8f4b", "pdf_src": "PubMed... |
Sources of heterogeneity in human monocyte subsets
Highlights • Variation in monocyte phenotype is explored using the markers CD14, CD16, HLA-DR, CX3CR1 and CCR2.• The CD14++CD16+ monocytes exhibit a spectrum of markers dependent on location within the gate.• Monocyte phenotype varies dependent on genetic background a... | [{"added": "2016-05-12T22:15:10.714Z", "created": "2013-04-01T00:00:00.000", "id": "13911943", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1016/j.imlet.2013.03.004", "pdf_hash": "a1353610b7d446e1a5a672796553577ab473ed73", "pdf_src"... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. Essentially, the ''maternal'' scheme assigned a non-zero score if the gene's expression pattern across the MP, 0P and 00 samples was consistent with the gene's expression being... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice
Background A sedentary lifestyle and poor diet are risk factors for the progression of non-alcoholic fatty liver disease. Furthermore, mice treated with a DHA/EPA ratio of 2:1 revealed greater decreases in ser... | [{"added": "2017-08-03T02:00:53.866Z", "created": "2017-03-29T00:00:00.000", "id": "6263760", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-017-0461-2", "pdf_hash": "426f645e7c804ff66391919785... |
Taxonomists always have had intense discussions about how species should be delimited and recently many studies have used integrative approaches by combining molecular, morphological, and bioacoustic data. For both algorithms we used 1000 as a maximum for iterative refinements. We conducted the search for the best par... | [{"added": "2020-02-23T14:03:36.936Z", "created": "2020-02-21T00:00:00.000", "id": "211246035", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0229324&type=printable", "pdf_hash": "1b1... |
DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice
Background Toxoplasma gondii is an obligate intracellular parasite that causes a pathological status known as toxoplasmosis, which has a huge impact on huma... | [{"added": "2017-06-30T08:33:14.274Z", "created": "2014-09-08T00:00:00.000", "id": "15962895", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/1756-3305-7-431", "pdf_hash": "13ac1df6905eb8b617... |
Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex
The majority of the polytopic proteins that are synthesized at the ER (endoplasmic reticulum) are integrated co-translationally via the Sec61 translocon, which provides lateral access for their hydrophobic TMs (t... | [{"added": "2017-11-13T05:37:00.817Z", "created": "2013-09-10T00:00:00.000", "id": "16601343", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.biochemj.org/content/456/2/297.full.pdf", "pdf_hash": "29dfab08cd3fb87d7a96fadd33cf10054a7e5664", "p... |
Sustained Receptor Stimulation Leads to Sequestration of Recycling Endosomes in a Classical Protein Kinase C- and Phospholipase D-dependent Manner* Considerable insight has been garnered on initial mechanisms of endocytosis of plasma membrane proteins and their subsequent trafficking through the endosomal compartment. ... | [{"added": "2018-04-03T02:39:25.834Z", "created": "2009-06-11T00:00:00.000", "id": "34567271", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/33/22322.full.pdf", "pdf_hash": "164261a7dc38abe3f7aa4ea69ff231f77a1a81a6", "pdf... |
DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice
Background Toxoplasma gondii is an obligate intracellular parasite that causes a pathological status known as toxoplasmosis, which has a huge impact on huma... | [{"added": "2017-06-30T08:33:14.274Z", "created": "2014-09-08T00:00:00.000", "id": "15962895", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/1756-3305-7-431", "pdf_hash": "13ac1df6905eb8b617... |
Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions*
Previous studies have shown that extracellular signal-regulated kinase 1/2 (ERK1/2) directly inhibits mitochondrial function during cellular i... | [{"added": "2018-04-03T05:55:04.429Z", "created": "2016-11-14T00:00:00.000", "id": "205361901", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/291/52/26850.full.pdf", "pdf_hash": "cf2aa24bad6550f11b5881747113c6ed002170d0", "pd... |
Coevolution Trumps Pleiotropy: Carbon Assimilation Traits Are Independent of Metabolic Network Structure in Budding Yeast Phenotypic traits may be gained and lost together because of pleiotropy, the involvement of common genes and networks, or because of simultaneous selection for multiple traits across environments (m... | [{"added": "2017-06-16T17:46:13.404Z", "created": "2013-01-10T00:00:00.000", "id": "7616198", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054403&type=printable", "pdf_hash": "a180e... |
14-3-3θ is a Binding Partner of Rat Eag1 Potassium Channels
To further explore the potential signaling pathways associated with mammalian Eag, we set forth to identify novel binding partners of rEag1 channels in the brain.
The potential interaction of 14-3-3h with the N-terminus of the rEag1 protein was further vali... | [{"added": "2016-05-12T22:15:10.714Z", "created": "2012-07-20T00:00:00.000", "id": "1783293", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041203&type=printable", "pdf_hash": "327b0... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. Maternal-imprint free embryos were previously reported to gain sporadically methylation at maternal ICRs of the Peg3 and Snrpn loci [18,22]. We indeed found 25% of 0P and 00 e... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
Taxonomists always have had intense discussions about how species should be delimited and recently many studies have used integrative approaches by combining molecular, morphological, and bioacoustic data. Sound files were deposited in the acoustic repositories of AAG-UFU and CFBH collections (see S2 Table). Voucher s... | [{"added": "2020-02-23T14:03:36.936Z", "created": "2020-02-21T00:00:00.000", "id": "211246035", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0229324&type=printable", "pdf_hash": "1b1... |
This below document has 2 sentences that start with '1 kcal = 4.184 kJ.\n\nFigure',
2 paragraphs that end with '1 kcal = 4.184 kJ'. It has approximately 506 words, 21 sentences, and 8 paragraph(s).
<<<<>>>>
Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex
The m... | [{"added": "2017-11-13T05:37:00.817Z", "created": "2013-09-10T00:00:00.000", "id": "16601343", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.biochemj.org/content/456/2/297.full.pdf", "pdf_hash": "29dfab08cd3fb87d7a96fadd33cf10054a7e5664", "p... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. This process, known as genomic imprinting, results from DNA methylation marks deposited in gametes at regulatory sequences called imprinting control regions (ICRs). Most of the... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. As expected, both 0P and 00 embryos showed an increased expression of the maternally repressed Kcnq1ot1 and Airn non-coding RNAs and a subsequent downregulation of Cdkn1c and I... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
Effect of Negative Pressure on Proliferation, Virulence Factor Secretion, Biofilm Formation, and Virulence-Regulated Gene Expression of Pseudomonas aeruginosa In Vitro Objective. aeruginosa by altering the metabolic rate.
Exotoxin A, rhamnolipid, and elastase are the main virulence factors secreted by P. aeruginosa, wh... | [{"added": "2018-04-03T01:10:36.741Z", "created": "2016-12-15T00:00:00.000", "id": "17029880", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://doi.org/10.1155/2016/7986234", "pdf_hash": "cbba8e5ac72f874376623b4dd75b65a0b20c8f4b", "pdf_src": "PubMed... |
Novel Host Proteins and Signaling Pathways in Enteropathogenic E. Another regulator of actin filament dynamics, HSP27, showed increased phosphorylation at Ser-82 in a T3SS-dependent manner during EPEC infection. Phosphorylation of Ser-82, one of three sites targeted by MAPKAP2, promotes actin filament formation (85,86)... | [{"added": "2018-04-03T04:27:16.045Z", "created": "2015-05-05T00:00:00.000", "id": "23416380", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1074/mcp.m114.046847", "pdf_hash": "9bdb2dc1724f8ddbdda04c9ace490d60f8e0716f", "pdf_src": "H... |
Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions*
Previous studies have shown that extracellular signal-regulated kinase 1/2 (ERK1/2) directly inhibits mitochondrial function during cellular i... | [{"added": "2018-04-03T05:55:04.429Z", "created": "2016-11-14T00:00:00.000", "id": "205361901", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/291/52/26850.full.pdf", "pdf_hash": "cf2aa24bad6550f11b5881747113c6ed002170d0", "pd... |
Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice
Background A sedentary lifestyle and poor diet are risk factors for the progression of non-alcoholic fatty liver disease. Moreover, a DHA/EPA ratio of 1:1 revealed the highest expression of enzymes such as AMP... | [{"added": "2017-08-03T02:00:53.866Z", "created": "2017-03-29T00:00:00.000", "id": "6263760", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-017-0461-2", "pdf_hash": "426f645e7c804ff66391919785... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. The substitution rates reported by Ambiore are independent of the overall different speeds with which intergenic and promoter regions evolved, that is in our case, within a seq... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex
The majority of the polytopic proteins that are synthesized at the ER (endoplasmic reticulum) are integrated co-translationally via the Sec61 translocon, which provides lateral access for their hydrophobic TMs (t... | [{"added": "2017-11-13T05:37:00.817Z", "created": "2013-09-10T00:00:00.000", "id": "16601343", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.biochemj.org/content/456/2/297.full.pdf", "pdf_hash": "29dfab08cd3fb87d7a96fadd33cf10054a7e5664", "p... |
Novel Host Proteins and Signaling Pathways in Enteropathogenic E. Two hours postinfection, cells were washed eight times with PBSϩ/ϩ to rinse off nonadherent bacteria. HeLa cells were lysed and adherent bacteria were released by incubation in 1% Triton-X-100 on a rocking platform at room temperature for 10 min. Subsequ... | [{"added": "2018-04-03T04:27:16.045Z", "created": "2015-05-05T00:00:00.000", "id": "23416380", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1074/mcp.m114.046847", "pdf_hash": "9bdb2dc1724f8ddbdda04c9ace490d60f8e0716f", "pdf_src": "H... |
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. Inosine can have a unplumbed effect on the RNAs that are edited, not only changing the base... | [{"added": "2017-05-09T16:41:51.382Z", "created": "2015-09-30T00:00:00.000", "id": "11272155", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://www.mdpi.com/2218-273X/5/4/2338/pdf", "pdf_hash": "019a9293cf4d9113faa648b5717abf464f06a129", "pdf_src": ... |
Effect of Negative Pressure on Proliferation, Virulence Factor Secretion, Biofilm Formation, and Virulence-Regulated Gene Expression of Pseudomonas aeruginosa In Vitro Objective. A value less than 0.05 was considered to be statistically significant.
Growth of P. aeruginosa under Negative Pressure.
The diameters of the... | [{"added": "2018-04-03T01:10:36.741Z", "created": "2016-12-15T00:00:00.000", "id": "17029880", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://doi.org/10.1155/2016/7986234", "pdf_hash": "cbba8e5ac72f874376623b4dd75b65a0b20c8f4b", "pdf_src": "PubMed... |
Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex
The majority of the polytopic proteins that are synthesized at the ER (endoplasmic reticulum) are integrated co-translationally via the Sec61 translocon, which provides lateral access for their hydrophobic TMs (t... | [{"added": "2017-11-13T05:37:00.817Z", "created": "2013-09-10T00:00:00.000", "id": "16601343", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.biochemj.org/content/456/2/297.full.pdf", "pdf_hash": "29dfab08cd3fb87d7a96fadd33cf10054a7e5664", "p... |
DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice
Background Toxoplasma gondii is an obligate intracellular parasite that causes a pathological status known as toxoplasmosis, which has a huge impact on huma... | [{"added": "2017-06-30T08:33:14.274Z", "created": "2014-09-08T00:00:00.000", "id": "15962895", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/1756-3305-7-431", "pdf_hash": "13ac1df6905eb8b617... |
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
Background EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. Calreticulin was ... | [{"added": "2016-05-17T03:20:48.815Z", "created": "2015-02-06T00:00:00.000", "id": "8037534", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/s12860-015-0047-7", "pdf_hash": "ff85844cfe70d09cad452e998... |
This below document has 2 sentences that end with 'Fouquet et al',
2 sentences that end with 'specimens of A'. It has approximately 352 words, 23 sentences, and 3 paragraph(s).
<<<<>>>>
Taxonomists always have had intense discussions about how species should be delimited and recently many studies have used integrative... | [{"added": "2020-02-23T14:03:36.936Z", "created": "2020-02-21T00:00:00.000", "id": "211246035", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0229324&type=printable", "pdf_hash": "1b1... |
Sources of heterogeneity in human monocyte subsets
Highlights • Variation in monocyte phenotype is explored using the markers CD14, CD16, HLA-DR, CX3CR1 and CCR2.• The CD14++CD16+ monocytes exhibit a spectrum of markers dependent on location within the gate.• Monocyte phenotype varies dependent on genetic background a... | [{"added": "2016-05-12T22:15:10.714Z", "created": "2013-04-01T00:00:00.000", "id": "13911943", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1016/j.imlet.2013.03.004", "pdf_hash": "a1353610b7d446e1a5a672796553577ab473ed73", "pdf_src"... |
Sources of heterogeneity in human monocyte subsets
Highlights • Variation in monocyte phenotype is explored using the markers CD14, CD16, HLA-DR, CX3CR1 and CCR2.• The CD14++CD16+ monocytes exhibit a spectrum of markers dependent on location within the gate.• Monocyte phenotype varies dependent on genetic background a... | [{"added": "2016-05-12T22:15:10.714Z", "created": "2013-04-01T00:00:00.000", "id": "13911943", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1016/j.imlet.2013.03.004", "pdf_hash": "a1353610b7d446e1a5a672796553577ab473ed73", "pdf_src"... |
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
Background EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. For total ricin a... | [{"added": "2016-05-17T03:20:48.815Z", "created": "2015-02-06T00:00:00.000", "id": "8037534", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/s12860-015-0047-7", "pdf_hash": "ff85844cfe70d09cad452e998... |
14-3-3θ is a Binding Partner of Rat Eag1 Potassium Channels
To further explore the potential signaling pathways associated with mammalian Eag, we set forth to identify novel binding partners of rEag1 channels in the brain. (Right panel) Cell lysates from myc-14-3-3h only or co-expression of rEag1 and myc-14-3-3h were... | [{"added": "2016-05-12T22:15:10.714Z", "created": "2012-07-20T00:00:00.000", "id": "1783293", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041203&type=printable", "pdf_hash": "327b0... |
Taxonomists always have had intense discussions about how species should be delimited and recently many studies have used integrative approaches by combining molecular, morphological, and bioacoustic data. Thus, we could reliably associate morphological and acoustic data for all specimens of candidate species from the... | [{"added": "2020-02-23T14:03:36.936Z", "created": "2020-02-21T00:00:00.000", "id": "211246035", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0229324&type=printable", "pdf_hash": "1b1... |
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. They are not confined to certain hotspots within ADAR1; rather, they are spread along the g... | [{"added": "2017-05-09T16:41:51.382Z", "created": "2015-09-30T00:00:00.000", "id": "11272155", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://www.mdpi.com/2218-273X/5/4/2338/pdf", "pdf_hash": "019a9293cf4d9113faa648b5717abf464f06a129", "pdf_src": ... |
Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice
Background A sedentary lifestyle and poor diet are risk factors for the progression of non-alcoholic fatty liver disease. The results show that treatment with n-3 PUFAs lowered the levels of serum ALT and AST ... | [{"added": "2017-08-03T02:00:53.866Z", "created": "2017-03-29T00:00:00.000", "id": "6263760", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-017-0461-2", "pdf_hash": "426f645e7c804ff66391919785... |
DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice
Background Toxoplasma gondii is an obligate intracellular parasite that causes a pathological status known as toxoplasmosis, which has a huge impact on huma... | [{"added": "2017-06-30T08:33:14.274Z", "created": "2014-09-08T00:00:00.000", "id": "15962895", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/1756-3305-7-431", "pdf_hash": "13ac1df6905eb8b617... |
14-3-3θ is a Binding Partner of Rat Eag1 Potassium Channels
To further explore the potential signaling pathways associated with mammalian Eag, we set forth to identify novel binding partners of rEag1 channels in the brain. We also applied difopein and the R18 mutant to verify the functional effect of 14-3-3h on rEag... | [{"added": "2016-05-12T22:15:10.714Z", "created": "2012-07-20T00:00:00.000", "id": "1783293", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041203&type=printable", "pdf_hash": "327b0... |
Novel Host Proteins and Signaling Pathways in Enteropathogenic E. The autophosphorylation and transactivation of EGFR are known to occur during EPEC infection (49) supporting the inclusion of this node within the STRING network. Although not directly resolved in our phosphoproteomic screen, probably because of its memb... | [{"added": "2018-04-03T04:27:16.045Z", "created": "2015-05-05T00:00:00.000", "id": "23416380", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1074/mcp.m114.046847", "pdf_hash": "9bdb2dc1724f8ddbdda04c9ace490d60f8e0716f", "pdf_src": "H... |
Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain*
Herpes simplex virus entry into cells requires a multipartite fusion apparatus made of glycoprotein D (gD), gB, and heterodimer gH/gL. The total amount of transfected plasmid DNA was mad... | [{"added": "2018-04-03T05:51:57.558Z", "created": "2009-04-22T00:00:00.000", "id": "22331065", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/26/17370.full.pdf", "pdf_hash": "4e8f64911e20eded6ecd92165c472e469686875d", "pdf... |
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
Background EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. We found that bot... | [{"added": "2016-05-17T03:20:48.815Z", "created": "2015-02-06T00:00:00.000", "id": "8037534", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/s12860-015-0047-7", "pdf_hash": "ff85844cfe70d09cad452e998... |
Novel Host Proteins and Signaling Pathways in Enteropathogenic E. Buffer A (0.1% formic acid) was used for the trap column. Peptides were eluted from the analytical column using 240 min gradient with following conditions: 100% buffer A (0.1% formic acid) to 32% buffer B (0.1% formic acid, 80% acetonitrile) in 210 min, ... | [{"added": "2018-04-03T04:27:16.045Z", "created": "2015-05-05T00:00:00.000", "id": "23416380", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1074/mcp.m114.046847", "pdf_hash": "9bdb2dc1724f8ddbdda04c9ace490d60f8e0716f", "pdf_src": "H... |
Coevolution Trumps Pleiotropy: Carbon Assimilation Traits Are Independent of Metabolic Network Structure in Budding Yeast Phenotypic traits may be gained and lost together because of pleiotropy, the involvement of common genes and networks, or because of simultaneous selection for multiple traits across environments (m... | [{"added": "2017-06-16T17:46:13.404Z", "created": "2013-01-10T00:00:00.000", "id": "7616198", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054403&type=printable", "pdf_hash": "a180e... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. Imprinting is linked to therian reproduction, that is, the placenta and imprinting emerged at roughly the same time and potentially co-evolved. We assessed the transcriptome-wi... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
Novel Host Proteins and Signaling Pathways in Enteropathogenic E. The bacterial translocated intimin receptor (Tir) is one of the first and most abundant effectors injected into the host cell: it mediates intimate attachment of EPEC to the enterocyte apical surface via its interaction with the bacterial surface adhesin... | [{"added": "2018-04-03T04:27:16.045Z", "created": "2015-05-05T00:00:00.000", "id": "23416380", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1074/mcp.m114.046847", "pdf_hash": "9bdb2dc1724f8ddbdda04c9ace490d60f8e0716f", "pdf_src": "H... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. On the contrary, maternal-dependent GO terms are highly clustered on the left towards p ,0.001, indicating a stronger biological impact of maternal imprints. B, Loss of materna... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
Background EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. It has been demo... | [{"added": "2016-05-17T03:20:48.815Z", "created": "2015-02-06T00:00:00.000", "id": "8037534", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/s12860-015-0047-7", "pdf_hash": "ff85844cfe70d09cad452e998... |
Coevolution Trumps Pleiotropy: Carbon Assimilation Traits Are Independent of Metabolic Network Structure in Budding Yeast Phenotypic traits may be gained and lost together because of pleiotropy, the involvement of common genes and networks, or because of simultaneous selection for multiple traits across environments (m... | [{"added": "2017-06-16T17:46:13.404Z", "created": "2013-01-10T00:00:00.000", "id": "7616198", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054403&type=printable", "pdf_hash": "a180e... |
### Q: Read this ... <missing text> for 24 h (data not shown) without altering total ERK1/2 (Fig. 1A). PGC-1␣ mRNA expression increased 1.8fold at 1 h and 2.8-fold at 4 h before decreasing to control levels at 24 h after trametinib exposure (Fig. 1B). The increase <missing text>
===
Fill in the missing text.
### Ass... | [{"added": "2018-04-03T05:55:04.429Z", "created": "2016-11-14T00:00:00.000", "id": "205361901", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/291/52/26850.full.pdf", "pdf_hash": "cf2aa24bad6550f11b5881747113c6ed002170d0", "pd... |
Sustained Receptor Stimulation Leads to Sequestration of Recycling Endosomes in a Classical Protein Kinase C- and Phospholipase D-dependent Manner* Considerable insight has been garnered on initial mechanisms of endocytosis of plasma membrane proteins and their subsequent trafficking through the endosomal compartment. ... | [{"added": "2018-04-03T02:39:25.834Z", "created": "2009-06-11T00:00:00.000", "id": "34567271", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/33/22322.full.pdf", "pdf_hash": "164261a7dc38abe3f7aa4ea69ff231f77a1a81a6", "pdf... |
This below document has 2 sentences that end with 'with anti-RTA antibodies was performed',
2 sentences that end with '3 hours at 37°C'. It has approximately 495 words, 20 sentences, and 7 paragraph(s).
<<<<>>>>
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human ... | [{"added": "2016-05-17T03:20:48.815Z", "created": "2015-02-06T00:00:00.000", "id": "8037534", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/s12860-015-0047-7", "pdf_hash": "ff85844cfe70d09cad452e998... |
This below document has 2 sentences that start with 'With respect to', 2 sentences that end with 'entry into the cell'. It has approximately 681 words, 25 sentences, and 5 paragraph(s).
<<<<>>>>
Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion ... | [{"added": "2018-04-03T05:51:57.558Z", "created": "2009-04-22T00:00:00.000", "id": "22331065", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/26/17370.full.pdf", "pdf_hash": "4e8f64911e20eded6ecd92165c472e469686875d", "pdf... |
Novel Host Proteins and Signaling Pathways in Enteropathogenic E. 5B). A total of 48 identical phosphosites were targeted by both EPEC and Shigella. Forty-four percent of these sites had a different regulation pattern, e.g. upregulated during EPEC infection but down-regulated during Shigella infection. The majority com... | [{"added": "2018-04-03T04:27:16.045Z", "created": "2015-05-05T00:00:00.000", "id": "23416380", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1074/mcp.m114.046847", "pdf_hash": "9bdb2dc1724f8ddbdda04c9ace490d60f8e0716f", "pdf_src": "H... |
Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice
Background A sedentary lifestyle and poor diet are risk factors for the progression of non-alcoholic fatty liver disease. MDA production was remarkably decreased by PUFA supplementation, and the inhibitory ef... | [{"added": "2017-08-03T02:00:53.866Z", "created": "2017-03-29T00:00:00.000", "id": "6263760", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-017-0461-2", "pdf_hash": "426f645e7c804ff66391919785... |
Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions*
Previous studies have shown that extracellular signal-regulated kinase 1/2 (ERK1/2) directly inhibits mitochondrial function during cellular i... | [{"added": "2018-04-03T05:55:04.429Z", "created": "2016-11-14T00:00:00.000", "id": "205361901", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/291/52/26850.full.pdf", "pdf_hash": "cf2aa24bad6550f11b5881747113c6ed002170d0", "pd... |
Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain*
Herpes simplex virus entry into cells requires a multipartite fusion apparatus made of glycoprotein D (gD), gB, and heterodimer gH/gL. The results in Fig. 8 show that gD ⌺240 -260 , and ... | [{"added": "2018-04-03T05:51:57.558Z", "created": "2009-04-22T00:00:00.000", "id": "22331065", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/26/17370.full.pdf", "pdf_hash": "4e8f64911e20eded6ecd92165c472e469686875d", "pdf... |
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
Background EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. Free wild-type R... | [{"added": "2016-05-17T03:20:48.815Z", "created": "2015-02-06T00:00:00.000", "id": "8037534", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/s12860-015-0047-7", "pdf_hash": "ff85844cfe70d09cad452e998... |
This below document has 2 paragraphs that start with 'Effect of Negative Pressure on'. It has approximately 363 words, 28 sentences, and 11 paragraph(s).
<<<<>>>>
Effect of Negative Pressure on Proliferation, Virulence Factor Secretion, Biofilm Formation, and Virulence-Regulated Gene Expression of Pseudomonas aeruginos... | [{"added": "2018-04-03T01:10:36.741Z", "created": "2016-12-15T00:00:00.000", "id": "17029880", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://doi.org/10.1155/2016/7986234", "pdf_hash": "cbba8e5ac72f874376623b4dd75b65a0b20c8f4b", "pdf_src": "PubMed... |
Sustained Receptor Stimulation Leads to Sequestration of Recycling Endosomes in a Classical Protein Kinase C- and Phospholipase D-dependent Manner* Considerable insight has been garnered on initial mechanisms of endocytosis of plasma membrane proteins and their subsequent trafficking through the endosomal compartment. ... | [{"added": "2018-04-03T02:39:25.834Z", "created": "2009-06-11T00:00:00.000", "id": "34567271", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/33/22322.full.pdf", "pdf_hash": "164261a7dc38abe3f7aa4ea69ff231f77a1a81a6", "pdf... |
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. Activation of RIG-I and MDA5 results in the recruitment of the mitochondrial antiviral sig... | [{"added": "2017-05-09T16:41:51.382Z", "created": "2015-09-30T00:00:00.000", "id": "11272155", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://www.mdpi.com/2218-273X/5/4/2338/pdf", "pdf_hash": "019a9293cf4d9113faa648b5717abf464f06a129", "pdf_src": ... |
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
Background EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. It remains unclea... | [{"added": "2016-05-17T03:20:48.815Z", "created": "2015-02-06T00:00:00.000", "id": "8037534", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/s12860-015-0047-7", "pdf_hash": "ff85844cfe70d09cad452e998... |
14-3-3θ is a Binding Partner of Rat Eag1 Potassium Channels
To further explore the potential signaling pathways associated with mammalian Eag, we set forth to identify novel binding partners of rEag1 channels in the brain. By applying the yeast twohybrid screening of a rat brain cDNA library, we have identified 14-3-... | [{"added": "2016-05-12T22:15:10.714Z", "created": "2012-07-20T00:00:00.000", "id": "1783293", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041203&type=printable", "pdf_hash": "327b0... |
Novel Host Proteins and Signaling Pathways in Enteropathogenic E. 1A). Thus, we defined 3 hpi as the late stage of EPEC infection, which is similar to times used to investigate EPEC effector function in previous studies (43). Finally, the intermediate stage of EPEC infection was defined as 1.5 hpi, a time point at whic... | [{"added": "2018-04-03T04:27:16.045Z", "created": "2015-05-05T00:00:00.000", "id": "23416380", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1074/mcp.m114.046847", "pdf_hash": "9bdb2dc1724f8ddbdda04c9ace490d60f8e0716f", "pdf_src": "H... |
Sources of heterogeneity in human monocyte subsets
Highlights • Variation in monocyte phenotype is explored using the markers CD14, CD16, HLA-DR, CX3CR1 and CCR2.• The CD14++CD16+ monocytes exhibit a spectrum of markers dependent on location within the gate.• Monocyte phenotype varies dependent on genetic background a... | [{"added": "2016-05-12T22:15:10.714Z", "created": "2013-04-01T00:00:00.000", "id": "13911943", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1016/j.imlet.2013.03.004", "pdf_hash": "a1353610b7d446e1a5a672796553577ab473ed73", "pdf_src"... |
Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex
The majority of the polytopic proteins that are synthesized at the ER (endoplasmic reticulum) are integrated co-translationally via the Sec61 translocon, which provides lateral access for their hydrophobic TMs (t... | [{"added": "2017-11-13T05:37:00.817Z", "created": "2013-09-10T00:00:00.000", "id": "16601343", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.biochemj.org/content/456/2/297.full.pdf", "pdf_hash": "29dfab08cd3fb87d7a96fadd33cf10054a7e5664", "p... |
Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain*
Herpes simplex virus entry into cells requires a multipartite fusion apparatus made of glycoprotein D (gD), gB, and heterodimer gH/gL. mAbs 52S, 53S, 30, and 5E1 were described (39 -41).... | [{"added": "2018-04-03T05:51:57.558Z", "created": "2009-04-22T00:00:00.000", "id": "22331065", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/26/17370.full.pdf", "pdf_hash": "4e8f64911e20eded6ecd92165c472e469686875d", "pdf... |
Novel Host Proteins and Signaling Pathways in Enteropathogenic E. These included RSK, GSK, PKC, Eph receptor tyrosine kinase, and CAMK2, suggesting that these kinases may also play a role in regulating phosphorylation during EPEC-infection. In summary, the kinase-oriented bioinformatic analysis of the phosphoproteomic ... | [{"added": "2018-04-03T04:27:16.045Z", "created": "2015-05-05T00:00:00.000", "id": "23416380", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "https://doi.org/10.1074/mcp.m114.046847", "pdf_hash": "9bdb2dc1724f8ddbdda04c9ace490d60f8e0716f", "pdf_src": "H... |
Taxonomists always have had intense discussions about how species should be delimited and recently many studies have used integrative approaches by combining molecular, morphological, and bioacoustic data. The tadpole was described by Heyer et al. [52] and it is endotrophic, remaining in foam nests throughout the whol... | [{"added": "2020-02-23T14:03:36.936Z", "created": "2020-02-21T00:00:00.000", "id": "211246035", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0229324&type=printable", "pdf_hash": "1b1... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. These developmental abnormalities can be explained by defective Figure 1. Methylation patterns in maternal-imprint free 0P and complete-imprint free 00 embryos at 8.5dpc. A, Bi... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. Therefore, the proposed mechanism of disease pathogenesis is thought to be the aberrant ac... | [{"added": "2017-05-09T16:41:51.382Z", "created": "2015-09-30T00:00:00.000", "id": "11272155", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://www.mdpi.com/2218-273X/5/4/2338/pdf", "pdf_hash": "019a9293cf4d9113faa648b5717abf464f06a129", "pdf_src": ... |
DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice
Background Toxoplasma gondii is an obligate intracellular parasite that causes a pathological status known as toxoplasmosis, which has a huge impact on huma... | [{"added": "2017-06-30T08:33:14.274Z", "created": "2014-09-08T00:00:00.000", "id": "15962895", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/1756-3305-7-431", "pdf_hash": "13ac1df6905eb8b617... |
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. These results indicated that PCA3 may act as a dominant-negative oncogene, whereas PRUNE2 i... | [{"added": "2017-05-09T16:41:51.382Z", "created": "2015-09-30T00:00:00.000", "id": "11272155", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://www.mdpi.com/2218-273X/5/4/2338/pdf", "pdf_hash": "019a9293cf4d9113faa648b5717abf464f06a129", "pdf_src": ... |
Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex
The majority of the polytopic proteins that are synthesized at the ER (endoplasmic reticulum) are integrated co-translationally via the Sec61 translocon, which provides lateral access for their hydrophobic TMs (t... | [{"added": "2017-11-13T05:37:00.817Z", "created": "2013-09-10T00:00:00.000", "id": "16601343", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.biochemj.org/content/456/2/297.full.pdf", "pdf_hash": "29dfab08cd3fb87d7a96fadd33cf10054a7e5664", "p... |
### Question: Add a conclusion.
===
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. These mice exhibited defects in motor function due to... | [{"added": "2017-05-09T16:41:51.382Z", "created": "2015-09-30T00:00:00.000", "id": "11272155", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://www.mdpi.com/2218-273X/5/4/2338/pdf", "pdf_hash": "019a9293cf4d9113faa648b5717abf464f06a129", "pdf_src": ... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. The 12 maternal ICRs that fell into the HI category were ejected from the HI category. Definition of genomic intervals and euarchontoglire species used to retrieve multiple al... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
Background EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. The results showe... | [{"added": "2016-05-17T03:20:48.815Z", "created": "2015-02-06T00:00:00.000", "id": "8037534", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/s12860-015-0047-7", "pdf_hash": "ff85844cfe70d09cad452e998... |
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. The transcript encoding PU.1 (Spi1) has multiple editing sites; however, the authors did no... | [{"added": "2017-05-09T16:41:51.382Z", "created": "2015-09-30T00:00:00.000", "id": "11272155", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://www.mdpi.com/2218-273X/5/4/2338/pdf", "pdf_hash": "019a9293cf4d9113faa648b5717abf464f06a129", "pdf_src": ... |
14-3-3θ is a Binding Partner of Rat Eag1 Potassium Channels
To further explore the potential signaling pathways associated with mammalian Eag, we set forth to identify novel binding partners of rEag1 channels in the brain. These coimmunoprecipitation and immunofluorescence data are representative of four to seven ind... | [{"added": "2016-05-12T22:15:10.714Z", "created": "2012-07-20T00:00:00.000", "id": "1783293", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041203&type=printable", "pdf_hash": "327b0... |
14-3-3θ is a Binding Partner of Rat Eag1 Potassium Channels
To further explore the potential signaling pathways associated with mammalian Eag, we set forth to identify novel binding partners of rEag1 channels in the brain. By contrast, no significant co-immunoprecipitation pattern was found for 14-3-3h and rEag2, an ... | [{"added": "2016-05-12T22:15:10.714Z", "created": "2012-07-20T00:00:00.000", "id": "1783293", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041203&type=printable", "pdf_hash": "327b0... |
New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. In this chapter we will focus on one of the most widespread and abundant type of post-trans... | [{"added": "2017-05-09T16:41:51.382Z", "created": "2015-09-30T00:00:00.000", "id": "11272155", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://www.mdpi.com/2218-273X/5/4/2338/pdf", "pdf_hash": "019a9293cf4d9113faa648b5717abf464f06a129", "pdf_src": ... |
This below document has 2 sentences that start with 'The 5E1 epitope',
2 sentences that start with 'The oligonucleotides contained',
3 sentences that start with 'The aa sequence of',
2 sentences that start with 'To generate gL'. It has approximately 671 words, 23 sentences, and 3 paragraph(s).
<<<<>>>>
Herpes Simplex V... | [{"added": "2018-04-03T05:51:57.558Z", "created": "2009-04-22T00:00:00.000", "id": "22331065", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/26/17370.full.pdf", "pdf_hash": "4e8f64911e20eded6ecd92165c472e469686875d", "pdf... |
Taxonomists always have had intense discussions about how species should be delimited and recently many studies have used integrative approaches by combining molecular, morphological, and bioacoustic data. [8][9][10]). Adenomera currently comprises 21species [11] and due to its complex taxonomy, most of them were desc... | [{"added": "2020-02-23T14:03:36.936Z", "created": "2020-02-21T00:00:00.000", "id": "211246035", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0229324&type=printable", "pdf_hash": "1b1... |
DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice
Background Toxoplasma gondii is an obligate intracellular parasite that causes a pathological status known as toxoplasmosis, which has a huge impact on huma... | [{"added": "2017-06-30T08:33:14.274Z", "created": "2014-09-08T00:00:00.000", "id": "15962895", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/1756-3305-7-431", "pdf_hash": "13ac1df6905eb8b617... |
Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions*
Previous studies have shown that extracellular signal-regulated kinase 1/2 (ERK1/2) directly inhibits mitochondrial function during cellular i... | [{"added": "2018-04-03T05:55:04.429Z", "created": "2016-11-14T00:00:00.000", "id": "205361901", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/291/52/26850.full.pdf", "pdf_hash": "cf2aa24bad6550f11b5881747113c6ed002170d0", "pd... |
In mammals, imprinted gene expression results from the sex-specific methylation of imprinted control regions (ICRs) in the parental germlines. Found at: doi:10.1371/journal.pgen.1001214.s003 (0.17 MB TIF) Figure S4 Rates of substitution occurring at CpG dinucleotides, analogous to Figure 6B, except that values were sp... | [{"added": "2016-05-17T13:49:14.336Z", "created": "2010-11-01T00:00:00.000", "id": "1775711", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001214&type=printable", "pdf_hash": "... |
This below document has 2 sentences that start with 'To enable detection of gH',
2 sentences that start with 'Infected cells were harvested 18',
2 sentences that end with 'Archipelago) 5E1 and gL 5E1',
2 sentences that end with 'harvested 18 h after infection'. It has approximately 639 words, 25 sentences, and 5 paragr... | [{"added": "2018-04-03T05:51:57.558Z", "created": "2009-04-22T00:00:00.000", "id": "22331065", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "HYBRID", "oa_url": "http://www.jbc.org/content/284/26/17370.full.pdf", "pdf_hash": "4e8f64911e20eded6ecd92165c472e469686875d", "pdf... |
Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
Background EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. Due to the Wester... | [{"added": "2016-05-17T03:20:48.815Z", "created": "2015-02-06T00:00:00.000", "id": "8037534", "metadata": {"extfieldsofstudy": ["Biology", "Medicine"], "oa_license": "CCBY", "oa_status": "GOLD", "oa_url": "https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/s12860-015-0047-7", "pdf_hash": "ff85844cfe70d09cad452e998... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.