doi string | pmcid string | plain_text string | technical_text string | full_text string | journal string | topics list | keywords list | llm_lingua2_text string | llm_lingua2_rate float64 | llm_lingua2_preproc_time float64 |
|---|---|---|---|---|---|---|---|---|---|---|
10.1038/s41467-020-16904-3 | PMC7308400 | Single cell RNA-seq is a powerful method to assign cell identity, but the purity of cell clusters arising from this data is not clear. Here the authors present an entropy-based statistic called ROGUE to quantify the purity of cell clusters, and identify subtypes within clusters. | Single-cell RNA sequencing (scRNA-seq) is a versatile tool for discovering and annotating cell types and states, but the determination and annotation of cell subtypes is often subjective and arbitrary. Often, it is not even clear whether a given cluster is uniform. Here we present an entropy-based statistic, ROGUE, to ... | IntroductionTissues are complex milieus comprising various cell types and states with specialized roles1. Characterizing the property and function of each pure cell type is a long-standing challenge in biological and medical disciplines. The recent advances in scRNA-seq have transformative potential to discover and ann... | nature communications | [
"Article"
] | [
"RNA sequencing",
"Computational models",
"Software"
] | complex cell types specialized roles1 Characterizing function cell type challenge advances scRNA-seq discover annotate cell types insights organ tumor microenvironment3 cell cell clusters checking signature genes arbitrary imprecise methods parameters normalization feature selection batch correction clustering confound... | 50.4 | 1.137954 |
10.1038/s41467-020-20466-9 | PMC7794343 | Dual oxidases (DUOXs), assembled from the catalytic DUOX and the auxiliary DUOXA subunits, produce hydrogen peroxide by transferring electrons from intracellular NADPH to extracellular oxygen in a calcium-activated manner. Here authors report the cryo-EM structures of human DUOX1-DUOXA1 complex in both high-calcium and... | Dual oxidases (DUOXs) produce hydrogen peroxide by transferring electrons from intracellular NADPH to extracellular oxygen. They are involved in many crucial biological processes and human diseases, especially in thyroid diseases. DUOXs are protein complexes co-assembled from the catalytic DUOX subunits and the auxilia... | IntroductionReactive oxygen species (ROS) are oxygen-containing chemical species that are highly reactive, such as hydrogen peroxide and superoxide anion1. They participate in many physiological processes and are implicated in several pathological conditions1. ROS can be generated by a class of dedicated enzymes called... | nature communications | [
"Article"
] | [
"Enzyme mechanisms",
"Oxidoreductases",
"Cryoelectron microscopy"
] | oxygen species (ROS) are oxygen reactive hydrogen peroxide superoxide participate in processes pathological ROS generated by NADPH oxidase (NOX) multi-pass transmembrane proteins catalyze reduction oxygen superoxide anion hydrogen peroxide NOX proteins in biological processes host defense differentiation development ce... | 50.3 | 0.740802 |
10.1038/s41467-020-17590-x | PMC7387547 | "In this study the authors show that monotonous basaltic volcanoes can host a range of melts in thei(...TRUNCATED) | "Many volcanoes erupt compositionally homogeneous magmas over timescales ranging from decades to mil(...TRUNCATED) | "IntroductionVolcanoes are underlain by complex and dynamic magmatic systems that often span tens of(...TRUNCATED) | nature communications | [
"Article"
] | [
"Geochemistry",
"Geology",
"Petrology",
"Volcanology"
] | "by complex magmatic systems kilometres crust from Moho to near-surface1,2 melts ascend undergo proc(...TRUNCATED) | 49.9 | 0.838315 |
10.1038/s41467-020-17400-4 | PMC7371698 | "Assessments of future virtual water trading are still lacking. Here the authors estimated the globa(...TRUNCATED) | "Water stressed regions rely heavily on the import of water-intensive goods to offset insufficient f(...TRUNCATED) | "IntroductionVirtual water trade (VWT) is the amount of water, either green (soil moisture) or blue (...TRUNCATED) | nature communications | [
"Article"
] | [
"Sustainability",
"Hydrology"
] | "IntroductionVirtual water trade (VWT) is water green or blue consumed in production agricultural go(...TRUNCATED) | 49.5 | 0.424733 |
10.1038/s41467-021-21363-5 | PMC7910301 | "Here, advanced scanning transmission electron microscopy techniques are used to image the atomic st(...TRUNCATED) | "The atomic structure at the interface between two-dimensional (2D) and three-dimensional (3D) mater(...TRUNCATED) | "IntroductionFollowing the success of moiré engineering in modulating (opto-)electronic properties (...TRUNCATED) | nature communications | [
"Article"
] | ["Surfaces, interfaces and thin films","Electronic properties and materials","Two-dimensional materi(...TRUNCATED) | "success moiré engineering properties/hexagonal boron nitride heterostructures1,2 twisted bilayer s(...TRUNCATED) | 49 | 0.584603 |
10.1038/s41467-020-17515-8 | PMC7393140 | "Here, the authors apply live-cell and in situ fluorescence imaging at the single-molecule level to (...TRUNCATED) | "Spatial organization of biological processes allows for variability in molecular outcomes and coord(...TRUNCATED) | "IntroductionOrganization is a fundamental part of life. For complex organisms, the spatial developm(...TRUNCATED) | nature communications | [
"Article"
] | [
"Bacteriophages",
"Cellular noise",
"Single-cell imaging"
] | "IntroductionOrganization fundamental life complex organisms spatial development controlled for func(...TRUNCATED) | 48.8 | 0.917512 |
10.1038/s41467-020-14616-2 | PMC7005897 | "Humans are normally not aware that their eyes are always in motion, even when attempting to maintai(...TRUNCATED) | "High visual acuity is essential for many tasks, from recognizing distant friends to driving a car. (...TRUNCATED) | "IntroductionHumans critically rely on high visual acuity. Although fine spatial resolution is restr(...TRUNCATED) | nature communications | [
"Article"
] | [
"Neural encoding",
"Oculomotor system",
"Sensorimotor processing",
"Visual system"
] | "rely on high visual acuity fine spatial resolution restricted to foveola tiny region retina less th(...TRUNCATED) | 46.6 | 1.105571 |
10.1038/s41467-020-17401-3 | PMC7374574 | "Orexin signaling is provided by diffusely distributed fibers and involved in different brain circui(...TRUNCATED) | "The relationship between orexin/hypocretin and rapid eye movement (REM) sleep remains elusive. Here(...TRUNCATED) | "IntroductionStable vigilance states, which fundamentally serve vital brain functions, depend on the(...TRUNCATED) | nature communications | [
"Article"
] | [
"Hypocretin",
"Hypocretin",
"Orexin",
"Orexin",
"REM sleep"
] | "vigilance states serve brain functions depend on neurochemical signals1 hypothalamic neuropeptide o(...TRUNCATED) | 47.3 | 1.381432 |
10.1038/s41467-020-19306-7 | PMC7595090 | "A conclusive account on how the brain translates audiovisual evidence into a rapid decision is stil(...TRUNCATED) | "Despite recent progress in understanding multisensory decision-making, a conclusive mechanistic acc(...TRUNCATED) | "IntroductionIn everyday life, we often encounter situations that demand rapid decisions based on am(...TRUNCATED) | nature communications | [
"Article"
] | [
"Neuroscience",
"Psychology"
] | "life situations rapid decisions ambiguous sensory information Consolidating evidence requires proce(...TRUNCATED) | 47 | 1.331961 |
10.1038/s41467-021-20907-z | PMC7846738 | "It is known that invasive lung adenocarcinomas evolve from pre-cancerous dysplastic lesions. In thi(...TRUNCATED) | "The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during early carcino(...TRUNCATED) | "IntroductionLung cancer remains the leading cause of cancer-related death worldwide, yet it is cura(...TRUNCATED) | nature communications | [
"Article"
] | [
"Cancer genomics",
"Non-small-cell lung cancer",
"Tumour heterogeneity",
"Epigenomics"
] | "cancer leading cause death curable if treated early cancers preceded by precancers Treating precanc(...TRUNCATED) | 49.1 | 0.889898 |
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