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Plumb's V eterinary Drug Handbook Sixth Edition Donald C. Plumb, Pharm. D. distributed by Blackwell Publishing | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
COPyri GHt © 2008 by d onald C. Plumb All rights reserved. No part of this book may be reproduced or transmitted in any form or any means, electronic or mechanical, including recording, photocopying, or by any information stor age and retrieval system, without the written permission of the copyright owner. worldwide pr... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
For Shirley, Whose efforts, support, and love make this reference a reality * * * | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Contributors to the Sixth Edition C. A. t ony b uffington, d VM, Phd, d ACVN Professor of Veterinary Clinical sciences the Ohio state u niversity Veterinary Hospital Columbus, OH Dog and Cat Therapeutic Diets Andrea G. Cannon, d VM, d ACVd Animal d ermatology & Allergy rocklin, CA; Modesto, CA; b oise, id Dermatologica... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Preface to the Sixth Edition in this edition, Plumb's Veterinary Drug Handbook continues to evolve with the addition of more drugs, more types of drugs (topical dermatology drugs), and a new look; however, the basic premise remains to serve as a single volume reference to assist veterinarians, other health professional... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Notes and Cautions Dosages and Extra-Label Use of Medications dosages for the various species for the drugs listed in this reference come from a variety of sources and are referenced to their source in the appendix. While a sincere effort has been made to assure that the dosages and information in cluded in this book a... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Contents Sy STEMIC MONOg RAPh S Acarbose 1 Acemannan 2 Acepromazine Maleate 3 Acetaminophen 6 Acetazolamide 7 Acetic Acid 9 Acetohydroxamic Acid 9 Acetylcysteine 10 Acitretin 12 Acyclovir 14 Aglepristone 15 Albendazole 17 Albuterol s ulfate 19 Alendronate s odium 21 Alfentanil HCl 22 Allopurinol 24 Alprazolam 26 Altren... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Cefaclor 141 Cefadroxil 143 Cefazolin s odium 144 Cefepime HCl 147 Cefixime 148 Cefoperazone s odium 149 Cefotaxime s odium 151 Cefotetan d isodium 153 Cefoxitin s odium 154 Cefpodoxime Proxetil 156 Ceftazidime 157 Ceftiofur Crystalline Free Acid 159 Ceftiofur HCl 161 Ceftiofur s odium 164 Ceftriaxone s odium 166 Cefur... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
diphenhydramine HCl 308 diphenoxylate HCl + Atropine s ulfate 310 dirlotapide 312 disopyramide Phosphate 314 dobutamine HCl 316 docusate 317 dolasetron Mesylate 319 domperidone 320 dopamine HCl 321 doramectin 323 doxapram HCl 325 doxepin HCl 327 doxorubicin HCl 328 doxycycline 331 edetate Calcium d isodium 334 edrophon... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
ibafloxacin 470 ifosfamide 471 imidocarb d ipropinate 473 imipenem-Cilastatin s odium 474 imipramine 476 inamrinone Lactate 478 insulin 479 interferon Alfa, Human r ecombinant 484 interferon Omega, Feline 486 iodide, s odium 487 iodide, Potassium 487 ipecac s yrup 488 ipodate s odium 490 ipratropium b romide 491 irbesa... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Moxidectin 635 Mycobacterial Cell Wall Fraction i mmunomodulator 637 Mycophenolate Mofetil 639 Naloxone HCl 641 Naltrexone HCl 642 Nandrolone d ecanoate 643 Naproxen 645 Narcotic (Opiate) Agonist Analgesics, Pharmacology of 647 N-butylscopolammonium b romide 647 Neomycin s ulfate 648 Neostigmine 651 Niacinamide 652 Nit... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Quinidine 797 ramipril 800 ranitidine HCl 801 rifampin 803 romifidine HCl 805 ronidazole 807 s-Adenosyl-Methionine (s AMe) 809 saline/Hyperosmotic Laxatives 810 selamectin 812 selegiline HCl 814 sertraline HCl 815 sevelamer HCl 817 sevoflurane 818 sildenafil Citrate 820 silymarin; Milk t histle 821 sodium b icarbonate ... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
APPENDIx Ophthalmic Products, t opical 945 routes of Administration For Ophthalmic drugs 945 diagnostic Agents 946 Fluorescein s odium 946 Lissamine Green 946 Phenol r ed t hread 947 Proparacaine 947 rose b engal 947 schirmer t ear t est 947 tetracaine 948 Glaucoma, t opical Agents 948 Parasmpathomimetics (Miotics) 949... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Artificial t ear Products/Ocular Lubricants 969 Ophthalmic i rrigants 969 topical Hyperosmotic Agents 970 Polysulfonated glycosaminoglycan 970 Hypertonic s odium Chloride 970 Viscoelastic s ubstances 970 Hyaluronic Acid 971 Cytotoxic Ophthalmic Agents 971 Cisplatin beads 971 5-Fluorouracil 971 Mitomycin-C 971 sympathom... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
reduced Protein/Phosphorus d iets for d ogs 1029 reduced energy d iets for d ogs 1030 restricted Mineral d iets for d ogs 1032 Geriatric d iets for d ogs 1032 dental d iets for d ogs 1034 Other t herapeutic d iets for d ogs 1034 therapeutic d iets for Cats 1035 Modified Fiber d iets for Cats 1035 Novel Protein d iets f... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
ctl5q-Veterinary_drug_hand_book_Plumbs.pdf | |
Ac Arbose (ay-kar-bose) Precose® Oral antidiabetic Prescriber Highlights Antihyperglycemic agent that reduces the rate & amount T T of glucose absorbed from the gut after a meal; may be use ful for mild reductions in blood glucose in dogs or cats Contraindications: Underweight animals, known hyper-T T sensitivity, diab... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
b) 12. 5 mg per cat PO twice daily with meals. May be able to reduce insulin dosage and thereby reduce hypoglycemia oc-currence. (Greco 2002b) c) 12. 5-20 mg (total dose) per meal PO (Daminet 2003) monitoring Serum glucose T! Adverse effects (diarrhea)T! Client Information Give immedi ately prior to feeding for best re... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Client Information This compound is recommended for use by veterinary profes-T! sionals only Clients should be made aware of the “investigational” nature of T! using acemannan systemically; adverse effects are possible Chemistry Acemannan is a complex carbohydrate polymer that is derived from Aloe vera. It is a long-ch... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
depression, seizures and death. Because of its effects on thermoregu-lation, use cautiously in very young or debilitated animals. Acepromazine has no analgesic effects; treat animals with ap-propriate analgesics to control pain. The tranquilization effects of acepromazine can be overridden and it cannot always be count... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
c) T o reduce anxiety in the painful patient (not a substitute for analgesia): 0. 05 mg/kg IM, IV or SC; do not exceed 1 mg total dose (Carroll 1999) d) 0. 55-2. 2 mg/kg PO or 0. 55-1. 1 mg/kg IV, IM or SC (Pack-age Insert; Prom Ace ® —Fort Dodge) e) As a premedicant with morphine: acepromazine 0. 05 mg/kg IM; morphine... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
6 ACETAm INOPHEN Acet Aminophen (ah-seet-a-min-a-fen) Tylenol®, APAP, Paracetamol Oral analgesic, antipyretic Prescriber Highlights Contraindicated in cats at any dosage; ferrets may be as T T sensitive to acetaminophen as cats At recommended dosages, not overly toxic to dogs, ro-T T dents, or rabbits Often used in com... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
ACETAz Ol Am IDE 7 monitoring may be warranted, particularly when clinical signs occur. Client Information Follow directions carefully; do not exceed dosage or increase dos-T! ing fre quency. Do not administer to cats or ferrets for any reason. Keep out of reach of children. Chemistry/Synonyms A synthetic non-opiate an... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
8 ACETAz Ol Am IDE At the dosages used for HYPP in horses adverse effects are report-edly uncommon. Reproductive/Nursing Safety Acetazolamide has been implicated in fetal abnormalities in mice and rats when used at high (10X) dosages) and fetal toxicity has been noted when the drug has been used in pregnant humans. In ... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
ACETIC ACID, ACETOHy DROx Am IC ACID 9 Acetazolamide Injection: 500 mg per vial; Diamox® (Wyeth-Ayerst); (Rx) Acetazolamide Powder for Injection (lyophilized): 500 mg for re-constitution; generic; (Rx) Acetic Acid (ah-see-tick ass-id) Vinegar gi acidifier Prescriber Highlights Used primarily for treatment of non-protei... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
10 ACETyl Cy STEINE carbonate. While the drug does not directly reduce urine p H, by re-ducing ammonia and bicarbonate production by urease-producing bacteria, it prevents in creases in urine p H. The drug may act syner-gistically with several antimicrobial agents (e. g., car benicillin, gen-tamicin, clindamycin, trime... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
ACETyl Cy STEINE 11 Uses/Indications Acetylcysteine is used in veterinary medicine as both a mucolytic agent in the pulmonary tree and as a treatment for acetaminophen or phenol toxicity in small animals. It has been used anecdotally with aminocaproic acid to treat degenerative myelopathy in dogs. In horses with strang... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
12 ACITRETIN b) 150 mg/kg PO or IV initially, then 50 mg/kg q4h for 17 ad-ditional doses (Bailey 1986a) For phenol toxicity: a) 140 mg/kg PO or IV initially, then 50 mg/kg q4h for 3 days. May be partially effective to reduce hepatic and renal injury. Resultant methemoglobinemia should be treated with ascor-bic acid or ... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
ACITRETIN 13 or sebaceous gland abnormalities in small animals. The drug has some antiinflammatory activity, but its exact mechanism of action is not known. Pharmacokinetics Acitretin absorption is enhanced by food in the gut. Acitretin is highly bound to plasma proteins. The drug is metabolized to conju-gate forms tha... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
14 ACy Cl OVIR Acyclovir (ay-sye-kloe-vir) Zovirax® antiviral (herpes) Prescriber Highlights Used primarily in birds for Pacheco's disease; may be use-T T ful in cats for Herpes infection If given rapidly IV, may be nephrotoxic T T Oral use may cause GI distress T T Reduce dosage with renal insufficiency T T May be fet... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Agl EPRISTONE 15 d) For prophylaxis: Exposed birds are given 25 mg/kg IM once (give IM with caution as it is very irritating), and then acy-clovir is added to drinking water at 1 mg/m L and to the food at 400 mg/quart of seed for a minimum of 7 days. Quaker parrots have been treated with a gavage of acyclovir at 80 mg/... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
16 Agl EPRISTONE Aglepristone also binds to glucocorticoid receptors but has no glucocorticoid activity; it can prevent endogenous or exogenously administered glucocorticoids from binding and acting at these sites. Pharmacokinetics In dogs, after injecting two doses of 10mg/kg 24 hours apart, peak serum levels occur ab... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Alb ENDAz Ol E 17 monitoring Clinical efficacy T! For pregnancy termination: ultrasound 10 days after treatment T! and at least 30 days after mating Adverse effects (see above)T! Client Information Only veterinary professionals should handle and administer this T! product When used for pregnancy termination in the bitc... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
18 Alb ENDAz Ol E Contraindications/Precautions/Warnings The drug is not approved for use in lactating dairy cattle. The manu-facturer recommends not administering to female cattle during the first 45 days of pregnancy or for 45 days after removal of bulls. In sheep, it should not be administered to ewes during the fir... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Alb UTEROl SUl FATE 19 c) For adult liver flukes in sheep: 7. 6 mg/kg (Paul 1986) d) For treatment of nematodes in sheep: 3 m L of suspension per 100 lbs of body weight PO (Bulgin 2003) b IRDS:T! a) Ratites: Using the suspension: 1 m L/22 kg of body weight twice daily for 3 days; repeat in 2 weeks. Has efficacy against... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
20 Alb UTEROl SUl FATE Reproductive/Nursing Safety In very large doses, albuterol is teratogenic in rodents. It should be used (particularly the oral dosage forms) during pregnancy only when the potential benefits outweigh the risks. Like some other beta agonists, it may delay pre-term labor after oral administration. ... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Al ENDRONATE SODIUm 21 HUm ANl Ab El ED PRODUCTS: Albuterol Tablets: 2 mg & 4 mg; Proventil ® (Schering); generic; (Rx) Albuterol Extended Release Tablets: 4 mg & 8 mg; Vo Spire® ER (Od-yssey); (Rx) Albuterol Syrup: 2 mg (as sulfate) per 5 m L in 473 m L & 480 m L; Proventil ® (Schering); generic; (Rx) Albuterol Aeros... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
22 Al FENTANIl HCl Overdosage/Acute Toxicity No lethality was observed in dogs receiving doses of up to 200 mg/ kg. Lethality in mice and rats was seen at dosages starting at 966 mg/kg and 552 mg/kg, respectively. Observed adverse effects associated with overdoses included hypocalcemia, hypophosphatemia, and up-per GI ... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Al FENTANIl HCl 23 the kidneys into the urine; only about 1% of the drug is excreted unchanged into the urine. T otal body clearance in humans ranges from 1. 6-17. 6 m L/minute/kg. Clearance is decreased by about 50% in patients with alcoholic cirrhosis or in those that are obese. Clearance is reduced by approximately ... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
24 All OPURINOl Allopurinol (al-oh-pyoor-i-nol) Zyloprim® Xanthine O Xidase inhibit Or; purine anal Og Prescriber Highlights Used as a uric acid reducer in dogs, cats, reptiles & birds T T & as an alternative treatment Leishmaniasis & Trypano-somiasis in dogs Use with caution (dosage adjustment may be required) in T T ... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
All OPURINOl 25 Drug Interactions The following drug interactions have either been reported or are theoretical in humans or animals receiving allopurinol and may be of significance in veterinary patients: Am INOPHyll INE !! or THEOPHyll INE : Large doses of allopurinol may decrease metabolism thereby increasing their s... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
26 Al PRAz Ol Am Alpr Azol Am (al-prah-zoe-lam) Xanax® benz Odiazepine sedative/tranquilizer Prescriber Highlights Oral benzodiazepine that may be useful for unwanted T T behaviors in dogs or cats Contraindications: Aggressive animals (controversial), T T benzodiazepine hypersensitivity Caution: Hepatic or renal diseas... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Al TRENOg EST 27 ANTACIDS!! : May slow the rate, but not the extent of oral absorption of alprazolam; administer 2 hours apart to avoid this potential interaction CNS DEPRESSANT Ag ENTS !! (barbiturates, narcotics, anesthetics, etc. ): Additive effects may occur DIg Ox IN!! : Serum levels may be increased; monitor seru... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
28 Al TRENOg EST estrus expression in show mares or mares to be raced. Although the drug is labeled as contraindicated during pregnancy, it has been demonstrated to maintain pregnancy in oophorectomized mares and may be of benefit in mares that abort due to sub-therapeutic pro gestin levels. The product Matrix® is labe... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
Al Um INUm Hy DROx IDE 29 Altrenogest can be absorbed after skin contact and absorption T! can be enhanced if the drug is covered by occlusive materials (e. g., under latex gloves, etc. ). If exposed to the skin, wash off im-mediately with soap and water. If the eyes are exposed, flush with water for 15 minutes and get... | ctl5q-Veterinary_drug_hand_book_Plumbs.pdf |
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