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1 Cognitive Vitality Reports 庐 are reports written by neuroscientists at the Alzheimer's Drug Discovery Foundation (ADDF). These scientific reports include analysis of drugs, drugs-in-development, drug targets, supplements, nutraceuticals, food/drink, non-pharmacologic interventions, and risk factors. Neuroscientists ... |
2 Availability : OTC from Chromadex and Elysium Health Dose : Clinical studies have used ~ 500-1000mg/day. Chemical formula: C11H15N2O5+ MW : 255. 25g/mol Half life : 2. 7 hrs BBB: Unknown in humans and unclear in mice Clinical trials : 3 safety and PK studies in 20 healthy adults (NR) and 120 elderly (Basis) Observat... |
3 Neuroprotective Benefit: Very promising particularly for prevention, no efficacy data in humans though. Types of evidence : 0 meta-analyses or systematic reviews 0 clinical trials and 0 observational studies Several laboratory studies; 1 contrary study. Many related studies on NAD+ or non-NR precursors 1 study on hu... |
4 increased neural stem cell p roliferation and neurogenesis in aged mice ( Zhang 2016 ) although another study reported that NR does not increase NAD+ levels in the brain ( Canto 2012 ). Other NAD+ boosting strategies have been reported to block toxicity from beta-amyloid, improve synaptic ( Wang 2016 ) and mitochond... |
5 12d vs 868 d +/-12. 4d) ( Zhang 2016 ). In rodents, NAD+ levels decline with h igh-fat diet but increase with calorie restriction or fasting ( Stein & Imai 2012 ), leading some to argue that it can function as a calorie restriction mimetic. Cell culture studies report that the effects of calorie restriction on repli... |
6 Toxicology animal report by Chromadex Details. NR is a dietary supplement generally considered safe (GRAS status from the FDA). Three PK/safety studies using NR or Basis were published. One open-label clinical study of 8 patients reported an increase in NR levels after 9 days of administration (1000mg 2x/day). The c... |
7 suggested this could be due to differences in LDL particle size or an increase in reverse cholesterol transport ( Dellinger et al, 2017 ). Another placebo-controlled randomized cross-over study in 24 healthy middle-aged and older adults reported that NR (1000mg/day) was safe and well-tolerated. There were no changes... |
8 160lb adult, that dose is equivalent to 42. 3 mg/kg in th e mouse, considerably lower than the roughly estimated 400-500 mg/kg/d used in many mouse studies. From a biological perspective, the goal should be to supplement enough to reverse the age-dependent decrease, not to cause artificially high NAD+ levels as m os... |
9 Disclaimer : Cognitive Vitality Reports 庐 do not provide, and should not be used for, medical advice, diagnosis, or treatment. You should consult with your he althcare providers when making decisions regarding your health. Your use of these reports constitutes your agreement to the Terms & Conditions. If you have su... |
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