text stringlengths 22 455 | relations listlengths 1 24 | messages listlengths 2 2 |
|---|---|---|
A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli. | [
{
"ade": "ischaemic cerebrovascular accident",
"drug": "streptokinase"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.",
"role": "user"
},
{
"content": "ade : ischaemic cerebrovascular accident drug : streptokinase",
"role": "assistant"
}
] |
We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively. | [
{
"ade": "hepatitis",
"drug": "riluzole"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.",
"role": "user"
},
{
"content": "ade : hepatitis drug : riluzole",
"role": "assistant"
}
] |
In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide. | [
{
"ade": "decrease in serum Na+",
"drug": "lorcainide"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.",
"role": "user"
},
{
"content": "ade : decrease in serum Na+ drug : lorcainide",
"role": "assistant"
}
] |
A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine. | [
{
"ade": "manic episode",
"drug": "fluoxetine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.",
"role": "user"
},
{
"content": "ade : manic episode drug : fluoxetine",
"role": "assistant"
}
] |
Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia. | [
{
"ade": "bilateral pulmonary infiltrates",
"drug": "methotrexate"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.",
"role": "user"
},
{
"content": "ade : bilateral pulmonary infiltrates drug : methotrexate",
"role": "assistant"
}
] |
We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment. | [
{
"ade": "cranial polyneuropathy",
"drug": "vincristine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.",
"role": "user"
},
{
"content": "ade : cranial polyneuropathy drug : vincristine",
"role": "assistant"
}
] |
RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies. | [
{
"ade": "weight loss",
"drug": "leflunomide"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.",
"role": "user"
},
{
"content": "ade : weight loss drug : leflunomide",
"role": "assistant"
}
] |
Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD. | [
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.",
"role": "user"
},
{
"content": "ade : thrombocytopenia drug : heparin",
"role": "assistant"
}
] |
Renal injury due to anastrozole has not been published in the English literature. | [
{
"ade": "Renal injury",
"drug": "anastrozole"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Renal injury due to anastrozole has not been published in the English literature.",
"role": "user"
},
{
"content": "ade : Renal injury drug : anastrozole",
"role": "assistant"
}
] |
Pulmonary toxicity with mefloquine. | [
{
"ade": "Pulmonary toxicity",
"drug": "mefloquine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Pulmonary toxicity with mefloquine.",
"role": "user"
},
{
"content": "ade : Pulmonary toxicity drug : mefloquine",
"role": "assistant"
}
] |
A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain. | [
{
"ade": "acute chest pain",
"drug": "ritodrine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.",
"role": "user"
},
{
"content": "ade : acute chest pain drug : ritodrine",
"role": "assistant"
}
] |
Recurrent hyponatremia associated with citalopram and mirtazapine. | [
{
"ade": "Recurrent hyponatremia",
"drug": "mirtazapine"
},
{
"ade": "Recurrent hyponatremia",
"drug": "citalopram"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Recurrent hyponatremia associated with citalopram and mirtazapine.",
"role": "user"
},
{
"content": "ade : Recurrent hyponatremia drug : mirtazapine",
"role": "assistant"
}
] |
This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate. | [
{
"ade": "hepatitis",
"drug": "artesunate"
},
{
"ade": "hepatitis",
"drug": "amodiaquine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.",
"role": "user"
},
{
"content": "ade : hepatitis drug : artesunate",
"role": "assistant"
}
] |
This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy. | [
{
"ade": "acute lung injury",
"drug": "mefloquine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.",
"role": "user"
},
{
"content": "ade : acute lung injury drug : mefloquine",
"role": "assistant"
}
] |
CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities. | [
{
"ade": "dermatologic and ocular 5-FU toxicities",
"drug": "5-FU"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.",
"role": "user"
},
{
"content": "ade : dermatologic and ocular 5-FU toxicities drug : 5-FU",
"role": "assistant"
}
] |
In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine. | [
{
"ade": "spasm",
"drug": "ergonovine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.",
"role": "user"
},
{
"content": "ade : spasm drug : ergonovine",
"role": "assistant"
}
] |
A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%. | [
{
"ade": "postprandial hyperglycemia",
"drug": "betamethasone valerate"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.",
"role": "user"
},
{
"content": "ade : postprandial hyperglycemia drug : betamethasone valerate",
"role": "assistant"
}
] |
One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy. | [
{
"ade": "ceroid-like pigment",
"drug": "clofazimine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.",
"role": "user"
},
{
"content": "ade : ceroid-like pigment drug : clofazimine",
"role": "assistant"
}
] |
CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL. | [
{
"ade": "Hypersensitivity reactions",
"drug": "cyclosporine"
},
{
"ade": "Hypersensitivity reactions",
"drug": "Cremophor EL"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.",
"role": "user"
},
{
"content": "ade : Hypersensitivity reactions drug : cyclosporine",
"role": "assistant"
}
] |
A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone. | [
{
"ade": "generalized tonic-clonic seizure",
"drug": "naloxone"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.",
"role": "user"
},
{
"content": "ade : generalized tonic-clonic seizure drug : naloxone",
"role": "assistant"
}
] |
The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs. | [
{
"ade": "radiation recall reactions",
"drug": "gemcitabine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.",
"role": "user"
},
{
"content": "ade : radiation recall reactions drug : gemcitabine",
"role": "assistant"
}
] |
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma. | [
{
"ade": "Intrahepatic cholestasis",
"drug": "glibenclamide"
},
{
"ade": "cutaneous bullae",
"drug": "glibenclamide"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.",
"role": "user"
},
{
"content": "ade : Intrahepatic cholestasis drug : glibenclamide",
"role": "assistant"
}
] |
This concerns 2 male patients who experienced incontinence while taking venlafaxine. | [
{
"ade": "incontinence",
"drug": "venlafaxine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: This concerns 2 male patients who experienced incontinence while taking venlafaxine.",
"role": "user"
},
{
"content": "ade : incontinence drug : venlafaxine",
"role": "assistant"
}
] |
Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps. | [
{
"ade": "Total blindness with a transient tonic pupillary response",
"drug": "quinine sulfate"
},
{
"ade": "denervation supersensitivity",
"drug": "quinine sulfate"
},
{
"ade": "abnormal visual-evoked potentials",
"drug": "quinine sulfate"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.",
"role": "user"
},
{
"content": "ade : Total blindness with a transient tonic pupillary response drug : quinine sulfate",
"role": "assistant"
}
] |
Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline. | [
{
"ade": "Pigmentary disorders",
"drug": "minocycline"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.",
"role": "user"
},
{
"content": "ade : Pigmentary disorders drug : minocycline",
"role": "assistant"
}
] |
Ticlopidine-induced marrow aplasia treated with cyclosporine. | [
{
"ade": "marrow aplasia",
"drug": "Ticlopidine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Ticlopidine-induced marrow aplasia treated with cyclosporine.",
"role": "user"
},
{
"content": "ade : marrow aplasia drug : Ticlopidine",
"role": "assistant"
}
] |
Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case. | [
{
"ade": "hypocalcemic tetany",
"drug": "fleet phospho-soda"
},
{
"ade": "hypocalcemic tetany",
"drug": "alendronate sodium"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.",
"role": "user"
},
{
"content": "ade : hypocalcemic tetany drug : fleet phospho-soda",
"role": "assistant"
}
] |
Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature. | [
{
"ade": "Cryptococcus neoformans fatal sepsis",
"drug": "alemtuzumab"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.",
"role": "user"
},
{
"content": "ade : Cryptococcus neoformans fatal sepsis drug : alemtuzumab",
"role": "assistant"
}
] |
Cough induced by quinapril with resolution after changing to fosinopril. | [
{
"ade": "Cough",
"drug": "quinapril"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Cough induced by quinapril with resolution after changing to fosinopril.",
"role": "user"
},
{
"content": "ade : Cough drug : quinapril",
"role": "assistant"
}
] |
Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed. | [
{
"ade": "catatonia",
"drug": "disulfiram"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.",
"role": "user"
},
{
"content": "ade : catatonia drug : disulfiram",
"role": "assistant"
}
] |
Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain. | [
{
"ade": "Fracture of the femoral neck",
"drug": "PSL"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.",
"role": "user"
},
{
"content": "ade : Fracture of the femoral neck drug : PSL",
"role": "assistant"
}
] |
Visual loss after a single small dose of vincristine has never been reported. | [
{
"ade": "Visual loss",
"drug": "vincristine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Visual loss after a single small dose of vincristine has never been reported.",
"role": "user"
},
{
"content": "ade : Visual loss drug : vincristine",
"role": "assistant"
}
] |
Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia. | [
{
"ade": "cranial nerve areflexia",
"drug": "CBZ"
},
{
"ade": "cortical hyperexcitability",
"drug": "CBZ"
},
{
"ade": "profound burst-suppression EEG pattern",
"drug": "CBZ"
},
{
"ade": "reversible encephalopathy",
"drug": "CBZ"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.",
"role": "user"
},
{
"content": "ade : cranial nerve areflexia drug : CBZ",
"role": "assistant"
}
] |
When measured, the serum lithium level had increased 4-fold during acyclovir therapy. | [
{
"ade": "serum lithium level had increased",
"drug": "acyclovir"
},
{
"ade": "serum lithium level had increased",
"drug": "lithium"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: When measured, the serum lithium level had increased 4-fold during acyclovir therapy.",
"role": "user"
},
{
"content": "ade : serum lithium level had increased drug : acyclovir",
"role": "assistant"
}
] |
Ezetimibe-induced acute pancreatitis. | [
{
"ade": "acute pancreatitis",
"drug": "Ezetimibe"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Ezetimibe-induced acute pancreatitis.",
"role": "user"
},
{
"content": "ade : acute pancreatitis drug : Ezetimibe",
"role": "assistant"
}
] |
The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA. | [
{
"ade": "ulcer",
"drug": "ATRA"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.",
"role": "user"
},
{
"content": "ade : ulcer drug : ATRA",
"role": "assistant"
}
] |
Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature. | [
{
"ade": "pulmonary toxicity",
"drug": "fludarabine"
},
{
"ade": "Multiple pulmonary nodules",
"drug": "fludarabine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.",
"role": "user"
},
{
"content": "ade : pulmonary toxicity drug : fludarabine",
"role": "assistant"
}
] |
Fulminant hepatic failure associated with bicalutamide. | [
{
"ade": "Fulminant hepatic failure",
"drug": "bicalutamide"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Fulminant hepatic failure associated with bicalutamide.",
"role": "user"
},
{
"content": "ade : Fulminant hepatic failure drug : bicalutamide",
"role": "assistant"
}
] |
These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis. | [
{
"ade": "TRAb/TBII without thyroid-stimulating activity",
"drug": "amiodarone"
},
{
"ade": "thyroiditis",
"drug": "amiodarone"
},
{
"ade": "destructive thyroiditis",
"drug": "amiodarone"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.",
"role": "user"
},
{
"content": "ade : TRAb/TBII without thyroid-stimulating activity drug : amiodarone",
"role": "assistant"
}
] |
The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range. | [
{
"ade": "lethargy",
"drug": "lithium"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.",
"role": "user"
},
{
"content": "ade : lethargy drug : lithium",
"role": "assistant"
}
] |
Spindle coma in benzodiazepine toxicity: case report. | [
{
"ade": "Spindle coma",
"drug": "benzodiazepine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Spindle coma in benzodiazepine toxicity: case report.",
"role": "user"
},
{
"content": "ade : Spindle coma drug : benzodiazepine",
"role": "assistant"
}
] |
Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment. | [
{
"ade": "Sudden cardiac death",
"drug": "clozapine"
},
{
"ade": "hypersensitivity myocarditis",
"drug": "clozapine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.",
"role": "user"
},
{
"content": "ade : Sudden cardiac death drug : clozapine",
"role": "assistant"
}
] |
PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment. | [
{
"ade": "anemia",
"drug": "ribavirin"
},
{
"ade": "anemia",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "progressive malaise",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "progressive malaise",
"drug": "ribavirin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.",
"role": "user"
},
{
"content": "ade : anemia drug : ribavirin",
"role": "assistant"
}
] |
Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon. | [
{
"ade": "congestive heart failure",
"drug": "recombinant alpha-interferon"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.",
"role": "user"
},
{
"content": "ade : congestive heart failure drug : recombinant alpha-interferon",
"role": "assistant"
}
] |
However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given. | [
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
},
{
"ade": "Stevens-Johnson syndrome",
"drug": "ofloxacin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.",
"role": "user"
},
{
"content": "ade : toxic epidermal necrolysis drug : ofloxacin",
"role": "assistant"
}
] |
Foscarnet-induced severe hypomagnesemia and other electrolyte disorders. | [
{
"ade": "electrolyte disorders",
"drug": "Foscarnet"
},
{
"ade": "severe hypomagnesemia",
"drug": "Foscarnet"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.",
"role": "user"
},
{
"content": "ade : electrolyte disorders drug : Foscarnet",
"role": "assistant"
}
] |
Intravenous valproate associated with significant hypotension in the treatment of status epilepticus. | [
{
"ade": "hypotension",
"drug": "valproate"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.",
"role": "user"
},
{
"content": "ade : hypotension drug : valproate",
"role": "assistant"
}
] |
To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy. | [
{
"ade": "gastric LPD",
"drug": "MTX"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.",
"role": "user"
},
{
"content": "ade : gastric LPD drug : MTX",
"role": "assistant"
}
] |
Ofloxacin: a probable cause of toxic epidermal necrolysis. | [
{
"ade": "toxic epidermal necrolysis",
"drug": "Ofloxacin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Ofloxacin: a probable cause of toxic epidermal necrolysis.",
"role": "user"
},
{
"content": "ade : toxic epidermal necrolysis drug : Ofloxacin",
"role": "assistant"
}
] |
Trimethoprim-sulfamethoxazole-induced aseptic meningitis. | [
{
"ade": "aseptic meningitis",
"drug": "Trimethoprim-sulfamethoxazole"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Trimethoprim-sulfamethoxazole-induced aseptic meningitis.",
"role": "user"
},
{
"content": "ade : aseptic meningitis drug : Trimethoprim-sulfamethoxazole",
"role": "assistant"
}
] |
Hepatotoxicity induced by cyproterone acetate: a report of three cases. | [
{
"ade": "Hepatotoxicity",
"drug": "cyproterone acetate"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Hepatotoxicity induced by cyproterone acetate: a report of three cases.",
"role": "user"
},
{
"content": "ade : Hepatotoxicity drug : cyproterone acetate",
"role": "assistant"
}
] |
Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine. | [
{
"ade": "Prolongation of the QT interval",
"drug": "halofantrine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.",
"role": "user"
},
{
"content": "ade : Prolongation of the QT interval drug : halofantrine",
"role": "assistant"
}
] |
We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer. | [
{
"ade": "skin toxicity",
"drug": "aminoglutethimide"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.",
"role": "user"
},
{
"content": "ade : skin toxicity drug : aminoglutethimide",
"role": "assistant"
}
] |
Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration. | [
{
"ade": "Acute myocardial ischemia",
"drug": "epinephrine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.",
"role": "user"
},
{
"content": "ade : Acute myocardial ischemia drug : epinephrine",
"role": "assistant"
}
] |
After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin. | [
{
"ade": "anaphylaxis",
"drug": "cisplatin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.",
"role": "user"
},
{
"content": "ade : anaphylaxis drug : cisplatin",
"role": "assistant"
}
] |
A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium. | [
{
"ade": "generalized rigidity",
"drug": "olanzapine"
},
{
"ade": "leukocytosis",
"drug": "olanzapine"
},
{
"ade": "fever",
"drug": "olanzapine"
},
{
"ade": "fever",
"drug": "lithium"
},
{
"ade": "leukocytosis",
"drug": "lithium"
},
{
"ade": "increased serum transaminase and creatine kinase",
"drug": "lithium"
},
{
"ade": "increased serum transaminase and creatine kinase",
"drug": "olanzapine"
},
{
"ade": "generalized rigidity",
"drug": "lithium"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.",
"role": "user"
},
{
"content": "ade : generalized rigidity drug : olanzapine",
"role": "assistant"
}
] |
A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy. | [
{
"ade": "exacerbation of a preexisting maladaptive behavior",
"drug": "phenobarbital"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.",
"role": "user"
},
{
"content": "ade : exacerbation of a preexisting maladaptive behavior drug : phenobarbital",
"role": "assistant"
}
] |
Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity. | [
{
"ade": "Cardiac arrest",
"drug": "esmolol"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.",
"role": "user"
},
{
"content": "ade : Cardiac arrest drug : esmolol",
"role": "assistant"
}
] |
Interference with the cortisol axis by the microtubule antagonist, CPH82. | [
{
"ade": "Interference with the cortisol axis",
"drug": "CPH82"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Interference with the cortisol axis by the microtubule antagonist, CPH82.",
"role": "user"
},
{
"content": "ade : Interference with the cortisol axis drug : CPH82",
"role": "assistant"
}
] |
A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis. | [
{
"ade": "sarcoma",
"drug": "cyclophosphamide"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.",
"role": "user"
},
{
"content": "ade : sarcoma drug : cyclophosphamide",
"role": "assistant"
}
] |
Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range. | [
{
"ade": "blood levels in the toxic range",
"drug": "phenytoin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.",
"role": "user"
},
{
"content": "ade : blood levels in the toxic range drug : phenytoin",
"role": "assistant"
}
] |
CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications. | [
{
"ade": "ischemic skin complications",
"drug": "vasopressin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.",
"role": "user"
},
{
"content": "ade : ischemic skin complications drug : vasopressin",
"role": "assistant"
}
] |
Transient global amnesia after clioquinol: five personal observations from outside Japan. | [
{
"ade": "Transient global amnesia",
"drug": "clioquinol"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Transient global amnesia after clioquinol: five personal observations from outside Japan.",
"role": "user"
},
{
"content": "ade : Transient global amnesia drug : clioquinol",
"role": "assistant"
}
] |
Withdrawal of Depakote resulted in resolution of the effusion. | [
{
"ade": "effusion",
"drug": "Depakote"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Withdrawal of Depakote resulted in resolution of the effusion.",
"role": "user"
},
{
"content": "ade : effusion drug : Depakote",
"role": "assistant"
}
] |
Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide. | [
{
"ade": "fibrotic lesions",
"drug": "cyclophosphamide"
},
{
"ade": "fibrotic lesions",
"drug": "bleomycin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.",
"role": "user"
},
{
"content": "ade : fibrotic lesions drug : cyclophosphamide",
"role": "assistant"
}
] |
We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren. | [
{
"ade": "hyperkalemia",
"drug": "aliskiren"
},
{
"ade": "acute renal failure",
"drug": "aliskiren"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.",
"role": "user"
},
{
"content": "ade : hyperkalemia drug : aliskiren",
"role": "assistant"
}
] |
We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants. | [
{
"ade": "hypernatraemia",
"drug": "Kayexalate"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.",
"role": "user"
},
{
"content": "ade : hypernatraemia drug : Kayexalate",
"role": "assistant"
}
] |
The mechanism of RTA induced by FK506 has not yet been clearly elucidated. | [
{
"ade": "RTA",
"drug": "FK506"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: The mechanism of RTA induced by FK506 has not yet been clearly elucidated.",
"role": "user"
},
{
"content": "ade : RTA drug : FK506",
"role": "assistant"
}
] |
We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association. | [
{
"ade": "SJS",
"drug": "nevirapine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.",
"role": "user"
},
{
"content": "ade : SJS drug : nevirapine",
"role": "assistant"
}
] |
Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines. | [
{
"ade": "Osteonecrosis",
"drug": "dexamethasone"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.",
"role": "user"
},
{
"content": "ade : Osteonecrosis drug : dexamethasone",
"role": "assistant"
}
] |
Adenosine-induced ventricular fibrillation. | [
{
"ade": "ventricular fibrillation",
"drug": "Adenosine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Adenosine-induced ventricular fibrillation.",
"role": "user"
},
{
"content": "ade : ventricular fibrillation drug : Adenosine",
"role": "assistant"
}
] |
The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine. | [
{
"ade": "severe thrombocytopoaenia",
"drug": "quinine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.",
"role": "user"
},
{
"content": "ade : severe thrombocytopoaenia drug : quinine",
"role": "assistant"
}
] |
Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside. | [
{
"ade": "demyelinating peripheral neuropathy",
"drug": "cytosine arabinoside"
},
{
"ade": "Horner's syndrome",
"drug": "cytosine arabinoside"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.",
"role": "user"
},
{
"content": "ade : demyelinating peripheral neuropathy drug : cytosine arabinoside",
"role": "assistant"
}
] |
Carbamazepine-induced hyperammonemia. | [
{
"ade": "hyperammonemia",
"drug": "Carbamazepine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Carbamazepine-induced hyperammonemia.",
"role": "user"
},
{
"content": "ade : hyperammonemia drug : Carbamazepine",
"role": "assistant"
}
] |
Corneal endothelial deposits associated with rifabutin use. | [
{
"ade": "Corneal endothelial deposits",
"drug": "rifabutin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Corneal endothelial deposits associated with rifabutin use.",
"role": "user"
},
{
"content": "ade : Corneal endothelial deposits drug : rifabutin",
"role": "assistant"
}
] |
CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis. | [
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.",
"role": "user"
},
{
"content": "ade : toxic epidermal necrolysis drug : ofloxacin",
"role": "assistant"
}
] |
We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative. | [
{
"ade": "severe hepatotoxicity",
"drug": "benzarone"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.",
"role": "user"
},
{
"content": "ade : severe hepatotoxicity drug : benzarone",
"role": "assistant"
}
] |
The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism. | [
{
"ade": "hypercortisolism",
"drug": "CPH82"
},
{
"ade": "suppression of the endogeneous production of ACTH and cortisol",
"drug": "CPH82"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.",
"role": "user"
},
{
"content": "ade : hypercortisolism drug : CPH82",
"role": "assistant"
}
] |
Severe acidosis from acetazolamide in a diabetic patient. | [
{
"ade": "Severe acidosis",
"drug": "acetazolamide"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Severe acidosis from acetazolamide in a diabetic patient.",
"role": "user"
},
{
"content": "ade : Severe acidosis drug : acetazolamide",
"role": "assistant"
}
] |
Rupture of a cerebral aneurysm associated with nifedipine treatment. | [
{
"ade": "Rupture of a cerebral aneurysm",
"drug": "nifedipine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Rupture of a cerebral aneurysm associated with nifedipine treatment.",
"role": "user"
},
{
"content": "ade : Rupture of a cerebral aneurysm drug : nifedipine",
"role": "assistant"
}
] |
CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing. | [
{
"ade": "delay corneal wound healing",
"drug": "colchicine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.",
"role": "user"
},
{
"content": "ade : delay corneal wound healing drug : colchicine",
"role": "assistant"
}
] |
We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved. | [
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "mizoribin"
},
{
"ade": "SIADH",
"drug": "mizoribin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.",
"role": "user"
},
{
"content": "ade : syndrome of inappropriate secretion of antidiuretic hormone drug : mizoribin",
"role": "assistant"
}
] |
Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed. | [
{
"ade": "methanol poisoning",
"drug": "methanol"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.",
"role": "user"
},
{
"content": "ade : methanol poisoning drug : methanol",
"role": "assistant"
}
] |
We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome. | [
{
"ade": "prolonged QT",
"drug": "methadone"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.",
"role": "user"
},
{
"content": "ade : prolonged QT drug : methadone",
"role": "assistant"
}
] |
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen. | [
{
"ade": "morbidity",
"drug": "hyperbaric oxygen"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.",
"role": "user"
},
{
"content": "ade : morbidity drug : hyperbaric oxygen",
"role": "assistant"
}
] |
We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements. | [
{
"ade": "diphasic dyskinesias",
"drug": "levo-dopa"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.",
"role": "user"
},
{
"content": "ade : diphasic dyskinesias drug : levo-dopa",
"role": "assistant"
}
] |
BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported. | [
{
"ade": "hemolytic-uremic syndrome",
"drug": "gemcitabine"
},
{
"ade": "HUS",
"drug": "Gemcitabine"
},
{
"ade": "HUS",
"drug": "gemcitabine"
},
{
"ade": "renal toxicity",
"drug": "Gemcitabine"
},
{
"ade": "hemolytic-uremic syndrome",
"drug": "Gemcitabine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.",
"role": "user"
},
{
"content": "ade : hemolytic-uremic syndrome drug : gemcitabine",
"role": "assistant"
}
] |
A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication. | [
{
"ade": "bromide intoxication",
"drug": "pyridostigmine bromide"
},
{
"ade": "postoperative psychosis",
"drug": "pyridostigmine bromide"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.",
"role": "user"
},
{
"content": "ade : bromide intoxication drug : pyridostigmine bromide",
"role": "assistant"
}
] |
Capecitabine-induced headache responding to diltiazem. | [
{
"ade": "headache",
"drug": "Capecitabine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Capecitabine-induced headache responding to diltiazem.",
"role": "user"
},
{
"content": "ade : headache drug : Capecitabine",
"role": "assistant"
}
] |
Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan). | [
{
"ade": "Acute non-lymphocytic leukemia",
"drug": "Treosulfan"
},
{
"ade": "Acute non-lymphocytic leukemia",
"drug": "dihydroxybusulfan"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).",
"role": "user"
},
{
"content": "ade : Acute non-lymphocytic leukemia drug : Treosulfan",
"role": "assistant"
}
] |
Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl. | [
{
"ade": "serotonin syndrome",
"drug": "citalopram"
},
{
"ade": "serotonin syndrome",
"drug": "fentanyl"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.",
"role": "user"
},
{
"content": "ade : serotonin syndrome drug : citalopram",
"role": "assistant"
}
] |
The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare. | [
{
"ade": "hypotension",
"drug": "verapamil"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.",
"role": "user"
},
{
"content": "ade : hypotension drug : verapamil",
"role": "assistant"
}
] |
Acute acoustic nerve palsy associated with vincristine therapy. | [
{
"ade": "Acute acoustic nerve palsy",
"drug": "vincristine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Acute acoustic nerve palsy associated with vincristine therapy.",
"role": "user"
},
{
"content": "ade : Acute acoustic nerve palsy drug : vincristine",
"role": "assistant"
}
] |
Disopyramide (Norpace)-induced hypoglycemia. | [
{
"ade": "hypoglycemia",
"drug": "Disopyramide"
},
{
"ade": "hypoglycemia",
"drug": "Norpace"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Disopyramide (Norpace)-induced hypoglycemia.",
"role": "user"
},
{
"content": "ade : hypoglycemia drug : Disopyramide",
"role": "assistant"
}
] |
We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses. | [
{
"ade": "local cutaneous reactions",
"drug": "pegylated interferon alfa-2b"
},
{
"ade": "local cutaneous reactions",
"drug": "ribavirin"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.",
"role": "user"
},
{
"content": "ade : local cutaneous reactions drug : pegylated interferon alfa-2b",
"role": "assistant"
}
] |
Capecitabine-induced multifocal leukoencephalopathy: a report of five cases. | [
{
"ade": "multifocal leukoencephalopathy",
"drug": "Capecitabine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.",
"role": "user"
},
{
"content": "ade : multifocal leukoencephalopathy drug : Capecitabine",
"role": "assistant"
}
] |
This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances. | [
{
"ade": "dysphagia",
"drug": "haloperidol"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.",
"role": "user"
},
{
"content": "ade : dysphagia drug : haloperidol",
"role": "assistant"
}
] |
The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia. | [
{
"ade": "dystonia",
"drug": "carbamazepine"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.",
"role": "user"
},
{
"content": "ade : dystonia drug : carbamazepine",
"role": "assistant"
}
] |
One patient had severe temporary weakness after an ampicillin sodium challenge. | [
{
"ade": "severe temporary weakness",
"drug": "ampicillin sodium"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: One patient had severe temporary weakness after an ampicillin sodium challenge.",
"role": "user"
},
{
"content": "ade : severe temporary weakness drug : ampicillin sodium",
"role": "assistant"
}
] |
Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review. | [
{
"ade": "hypertrophic obstructive cardiomyopathy",
"drug": "dexamethasone"
}
] | [
{
"content": "Extract drugs that cause the adverse drug effect (ADE) relationships from the clinical text ### TEXT: Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review.",
"role": "user"
},
{
"content": "ade : hypertrophic obstructive cardiomyopathy drug : dexamethasone",
"role": "assistant"
}
] |
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