protein_name stringlengths 7 11 | species stringclasses 219
values | sequence stringlengths 2 34.4k | annotation stringlengths 6 11.5k | messages listlengths 3 3 |
|---|---|---|---|---|
TIGD5_HUMAN | Homo sapiens | MYPAGPPAGPVPRRGRRPLPGPPAPAPAPVPAARPPPPAPGPRPRVAVKMAFRKAYSIKDKLQAIERVKGGERQASVCRDFGVPGGTLRGWLKDEPKLRWFLEQLGGEVGTQRKKMRLANEEEIDRAVYAWFLALRQHGVPLSGPLIQAQAEAFARQIYGPECTFKASHGWFWRWQKRHGISSQRFYGEAGPPAPSPAPGPPVKEEPALPSGAGPLPDRAPAPPPPAEGGYGDEQIYSASVTGLYWKLLPEQAAPPGAGDPGAGGCGRRWRGDRVTVLLAANLTGSHKLKPLVIGRLPDPPSLRHHNQDKFPASYRYSPD... | Subcellular locations: Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MFGM_HUMAN | Homo sapiens | MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYK... | Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Als... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NU6M_PANTR | Pan troglodytes | MTYALFLLSVSLVMGFVGFSSKPSPIYGGLVLIVSGVVGCAIILNYGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKGYDGMVVVVNFNSVGSWMIYEGEGPGLIREDPIGAGALYDYGRWLVVVTGWTLFVGVYIVIEIARGN | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular locations: Mitochondrion inner memb... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
RN168_HUMAN | Homo sapiens | MALPKDAIPSLSECQCGICMEILVEPVTLPCNHTLCKPCFQSTVEKASLCCPFCRRRVSSWTRYHTRRNSLVNVELWTIIQKHYPRECKLRASGQESEEVADDYQPVRLLSKPGELRREYEEEISKVAAERRASEEEENKASEEYIQRLLAEEEEEEKRQAEKRRRAMEEQLKSDEELARKLSIDINNFCEGSISASPLNSRKSDPVTPKSEKKSKNKQRNTGDIQKYLTPKSQFGSASHSEAVQEVRKDSVSKDIDSSDRKSPTGQDTEIEDMPTLSPQISLGVGEQGADSSIESPMPWLCACGAEWYHEGNVKTRPSN... | E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NU1M_NYCCO | Nycticebus coucang | MFMVNLLMLVIPVMLAMAFLTLLERKTLGYMQFRKGPNVVGPNGLLQPFADAMKLFIKEPLQPLTSSTSLYIIAPTLALSIALIMWTPLPIPYPLVNINLGVLFILATSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLCILLMSGSFTLSTLIKTQEHTWLLLPSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYTNIIMMNALTATIFMSAIHSMNFPEFFSINFTLKTLLLTTIFLWVRASYPRFRYDQLMHLLWKNFLPLTLAMCMWHTALPIFLANIPPQT | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubi... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
KISHB_PONAB | Pongo abelii | MTNVYSLDGILVFGLLFVCTCAYFKKVPRLKTWLLSEKKGVWGVFYKAAVIGTRLHAAVAIACVVMAFYVLFIK | Involved in the early part of the secretory pathway.
Subcellular locations: Golgi apparatus membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ZN331_PONAB | Pongo abelii | MAQGLVTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLDLESAYENKSLPTEKNIHEIRASKRNSDRRSKSLGRNWICEGMLERPQRSRGRYVNQMIINYVKRPATREGTPPRTHQRHHKENSFECKDCGKAFSRGYQLSQHQKIHTGEKPYECKECKKAFRWGNQLTQHQKIHTGEKPYECKDCGKAFRWGSSLVIHKRIHTGEKPYECKDCGKAFRRGDELTQHQRFHTGEKDYECKDCGKTFSRVYKLIQHKRIHSGEKPYECKDCGKAFICGSSLIQHKRIHTGEKPYECQECGKAFTRVNYLTQHQKI... | May be involved in transcriptional regulation. May play a role in spermatogenesis (By similarity).
Subcellular locations: Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PCSK9_SAIBB | Saimiri boliviensis boliviensis | MGTVSSRRLWWPLPLLLLLLLLGPAGARAQEDDDGDYEELVLALRSEEDGLADALQHGATATFHRCAKEPWRLPGTYVVVLKEETHRSQPERTARRLQAQAARRGYLIKLLHVFHDLLPGFLVKMSRDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPARYRADEYQPPNGGSLVEVYLLDTSIQSGHREIEGRVMVTDFGSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASLRSLRVLNCQGKGTVSSTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVAAAGNFRDD... | Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradati... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
S23A3_HUMAN | Homo sapiens | MSRSPLNPSQLRSVGSQDALAPLPPPAPQNPSTHSWDPLCGSLPWGLSCLLALQHVLVMASLLCVSHLLLLCSLSPGGLSYSPSQLLASSFFSCGMSTILQTWMGSRLPLVQAPSLEFLIPALVLTSQKLPRAIQTPGNSSLMLHLCRGPSCHGLGHWNTSLQEVSGAVVVSGLLQGMMGLLGSPGHVFPHCGPLVLAPSLVVAGLSAHREVAQFCFTHWGLALLVILLMVVCSQHLGSCQFHVCPWRRASTSSTHTPLPVFRLLSVLIPVACVWIVSAFVGFSVIPQELSAPTKAPWIWLPHPGEWNWPLLTPRALAAG... | Acts as a sodium-dependent hypoxanthine transporter . May show xanthine-hypoxanthine exchange activity .
Subcellular locations: Membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
UD3A2_HUMAN | Homo sapiens | MAGQRVLLLVGFLLPGVLLSEAAKILTISTVGGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFMPDFKKEEKSYQVISWLAPEDHQREFKKSFDFFLEETLGGRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNENFDMVIVETFDYCPFLIAEKLGKPFVAILSTSFGSLEFGLPIPLSYVPVFRSLLTDHMDFWGRVKNFLMFFSFCRRQQHMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGGLMEKPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPEIFKEMNNAF... | UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous com... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CD40L_CERAT | Cercocebus atys | MIETYNQPSPRSAATGLPVRMKIFMYLLTIFLITQMIGSALFAVYLHRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEEKKKENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL | Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By simil... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
XRCC4_HUMAN | Homo sapiens | MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMAMEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPAEVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSRPDSSLPETSKKEHISAENMS... | DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination ( ). Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs) ( , ). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA a... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CPT1B_HUMAN | Homo sapiens | MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTGIFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPRVSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALGIVPMCSYQMERMFNTTRIPG... | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion.
Subcellular locations: Mitochondrion outer membrane
Strong expression in heart and skeletal ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PAX6_HUMAN | Homo sapiens | MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDT... | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates speci... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
GRPE1_PONAB | Pongo abelii | MAAQCVRLARRSLPALALSLRPSPRLLCTATKQKNSGQNLEEDMGQSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKEA | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
Subcel... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
RTEL1_HUMAN | Homo sapiens | MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLTQVINELRNTSYRPKVCVLGSREQLCIHPEVKKQESNHLQIHLCRKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKM... | ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TRIM5_MACFA | Macaca fascicularis | MASGILLNVKEEVTCPICLELLTEPLSLHCGHSFCQACITANHKKSMLYKEGERSCPVCRISYQPENIQPNRHVANIVEKLREVKLSPEEGQKVDHCARHGEKLLLFCQEDSKVICWLCERSQEHRGHHTFLMEEVAQEYHVKLQTALEMLRQKQQEAEKLEADIREEKASWKIQIDHDKTNVLADFEQLREILDREESNELQNLEKEKEDILKSLTKSETKMVQQTQYVRELISDLEHRLQGSMMELLQGVDGIIKRIENMTLKKPKTFHKNQRRVFRAPDLKGMLDMFRELTDARRYWVDVTLAPNNISHAVIAEDKR... | Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates i... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ADRB1_MACMU | Macaca mulatta | MGAGALVLGASEPGNLSSAAPLPDGVATAARLLVPASPPASLLPPASEGPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPSPSPVPAPPPGPPRPAAAAATTAPLVNGRAGKRRPSRLVAL... | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the reg... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CO7_HUMAN | Homo sapiens | MKVISLFILVGFIGEFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSSSSRSYTSHTNEIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVD... | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
Subcellular locations: Secreted | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
WF10B_HUMAN | Homo sapiens | MAPQTLLLVLVLCVLLLQAQGGYRDKMRMQRIKVCEKRPSIDLCIHHCSYFQKCETNKICCSAFCGNICMSIL | Subcellular locations: Secreted
Ubiquitously expressed. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
IVD_PONAB | Pongo abelii | MATATRLLGWRVASWRMRPPPAGFVSQRAHSLLPVDDAINGLSEEQRQLRQTVAKFLQEHLAPKAQEIDRSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKVPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQ... | Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.
Subcel... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
T22D1_HUMAN | Homo sapiens | MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGSGSASALNAAGTGVGSNATSSEDFPPPSLLQPPPPAASSTSGPQPPPPQSLNLLSQAQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASITGGPPSSPVSRKLSTTGSSDSITPVAPTSAVSSSGSPASVMTNMRAPSTTGGIGINSVTGTSTVNNVNITA... | Transcriptional repressor . Acts on the C-type natriuretic peptide (CNP) promoter . Acts to promote CASP3-mediated apoptosis . Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-med... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MYC_PANTR | Pan troglodytes | MDFFRIVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCPSQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTH... | Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, contro... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
FBXW8_HUMAN | Homo sapiens | MDDYSLDEFRRRWQEELAQAQAPKKRRRPEAAERRARRPEVGSGRGEQASGDPALAQRLLEGAGRPPAARATRAEGQDVASRSRSPLAREGAGGGEQLVDQLIRDLNEMNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSSISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWDLRTGKYPVHRFEHDARIQALALSQDDATVATASAF... | Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
KTDAP_HUMAN | Homo sapiens | MKIPVLPAVVLLSLLVLHSAQGATLGGPEEESTIENYASRPEAFNTPFLNIDKLRSAFKADEFLNWHALFESIKRKLPFLNWDAFPKLKGLRSATPDAQ | May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.
Subcellular locations: Secreted
Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in lamellar granules of granular keratinocytes and in the intracellular ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NDUS5_GORGO | Gorilla gorilla gorilla | MPFLDIQKRFGLNIDRWLTIQSAEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIRKQRDKLIKEGKYTPPPHHIGKGEPRP | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellula... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SPSB1_HUMAN | Homo sapiens | MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (, ). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macroph... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ACADV_MACFA | Macaca fascicularis | MQAARIAPSLGRQLLRFGGGSSRPTALLGQPWPGPARRPYAGGAAQLALDKSDSHLSDALNKAKPAKAESKSFAVAMFKGQLTTDQVFPYPSVLNQEQTEFLKELVEPVSRFFEEVNDPAKNDTLEMVEETTLQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLAVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETLAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGVTHGPPEKKMGIKASNTAEVLFDGVRVPSE... | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consist... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CCL2_HUMAN | Homo sapiens | MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT | Acts as a ligand for C-C chemokine receptor CCR2 ( ). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (, ). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils ( ). May be involved in the r... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SP7_HUMAN | Homo sapiens | MASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKAGTKKPYSVGSDLSASKTMGDAYPAPFTSTNGLLSPAGSPPAPTSGYANDYPPFSHSFPGPTGTQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLPTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQLEGSGGAKPPRGASTGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTG... | Transcriptional activator essential for osteoblast differentiation . Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).
Subcellular locations: Nucleus
Restricted to bone-derived cell. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
T2R42_MACMU | Macaca mulatta | MATEMDKIFLTLATVEFIIGMLGNVFIGLVNCSEGIKNQKVFSVDFILTCLAISTIGHLLVILFDSCVVGLAPHLYATDRVRRPVTMLWHMXNHLTTWLATCLSIFYFFKIAHFPHSLFLWLRWRMNRVIAILLTLSLFLLIFDCLVLEMFIDXSLNIIDKSNLTLYLDESKTPYDKLSLLKILLSLNSFIPFSLCLTSLLFLFLSLVRHTRNLKLSSLGSRDSSTEAHRRAMKMVMSLLFLFIVHFFSLQVANWTFCILGNNKYTQFVTLALHAFPSCHSFILILGNSKLRQTAVRLLWHLRNYTKRPNPLPL | Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Subcellu... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DIK2B_HUMAN | Homo sapiens | MEPQLGPEAAALRPGWLALLLWVSALSCSFSLPASSLSSLVPQVRTSYNFGRTFLGLDKCNACIGTSICKKFFKEEIRSDNWLASHLGLPPDSLLSYPANYSDDSKIWRPVEIFRLVSKYQNEISDRRICASASAPKTCSIERVLRKTERFQKWLQAKRLTPDLVQGLASPLLRCPSQRLLDRVVRRYAEVADAGSIFMDHFTDRDKLRLLYTLAVNSHPILLQIFPGAEGWPLPKYLGSCGRFLVSTSTRPLQEFYDAPPDQAADLAYQLLGVLESLRSNDLNYFFYFTHIDAGMFGVFNNGHLFIRDASAVGVIDKQE... | Subcellular locations: Secreted | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DNJB3_HUMAN | Homo sapiens | MVDYYEVLDVPRQASSEAIKKAYRKLALKWHPDKNPENKEEAERRFKQVAEAYEVLSDAKKRDIYDRYGEAGAEGGCTGGRPFEDPFEYVFSFRDPADVFREFFGGQDPFSFDLLGNPLENILGGSEELLGKQKQSVCTPFLCLQ | May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.
Expressed in sperm (at protein level). | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
HBG1_HYLLA | Hylobates lar | MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGGAIKNLDDLKGTFAQLSELHCDKLHVDPENFRLLGNVLVTVLAIHFGKEFTPEVQASWQKMVAGVASALSSRYH | Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
Red blood cells. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
EHD4_HUMAN | Homo sapiens | MFSWMGRQAGGRERAGGADAVQTVTGGLRSLYLRKVLPLEEAYRFHEFHSPALEDADFENKPMILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISVIDSPGILSGEKQRISRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKE... | ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.
Subcellular locations: Early endosome membrane, Recycling endosome membrane, Cell membrane
Highly expressed in pancreas and heart. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NU4M_LEMCA | Lemur catta | MLKIIIPTIMLFPVTWCSSSPMIWINTTLHSLLISLAGLLFLNQFNDSNNNFSLTFFSDSLSSPLVVLTMWLLPLMIMASQHHLKKEPWTLKKLYISMLIFLQMFLIMTFTATELILFYILFEATLIPTLIIITRWGNQTERLNAGLYFLFYTLIGSLPLLVALIHIQNYLGSLNMLTMSFCFQELSNSWSSNLLWMACIMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRITMILNPMTKYMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATILMIAHG... | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular locations: Mitochondrion inner memb... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ACTBM_HUMAN | Homo sapiens | MDDDTAVLVIDNGSGMCKAGFAGDDAPQAVFPSIVGRPRHQGMMEGMHQKESYVGKEAQSKRGMLTLKYPMEHGIITNWDDMEKIWHHTFYNELRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYTSGRTTGIVMDSGDGFTHTVPIYEGNALPHATLRLDLAGRELTDYLMKILTERGYRFTTTAEQEIVRDIKEKLCYVALDSEQEMAMAASSSSVEKSYELPDGQVITIGNERFRCPEALFQPCFLGMESCGIHKTTFNSIVKSDVDIRKDLYTNTVLSGGTTMYPGIAHRMQKEITAL... | Subcellular locations: Cytoplasm, Cytoskeleton
Expressed in some hepatocellular carcinomas. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TRAK2_HUMAN | Homo sapiens | MSQSQNAIFTSPTGEENLMNSNHRDSESITDVCSNEDLPEVELVSLLEEQLPQYRLKVDTLFLYENQDWTQSPHQRQHASDALSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQVNQLQHELCKKDELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLEMLQEKLKELEEENMALRSKACHIKTETVTYEEKEQQLVSDCVKELRETNAQMSRMTEELSGKSDELIRYQEELSSLLSQIVDLQHKLKEHVIEKEELKLHLQASKDAQR... | May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.
Subcellular locations: Cytoplasm, Early endosome, Mitochondrion
Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity).
Widely expressed, with highest exp... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TBPL1_MACFA | Macaca fascicularis | MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL | Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box (By similarity).
Subcellular locations: Cytoplasm, Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PLA2R_HUMAN | Homo sapiens | MLLSPSLLLLLLLGAPRGCAEGVAAALTPERLLEWQDKGIFVIQSESLKKCIQAGKSVLTLENCKQANKHMLWKWVSNHGLFNIGGSGCLGLNFSAPEQPLSLYECDSTLVSLRWRCNRKMITGPLQYSVQVAHDNTVVASRKYIHKWISYGSGGGDICEYLHKDLHTIKGNTHGMPCMFPFQYNHQWHHECTREGREDDLLWCATTSRYERDEKWGFCPDPTSAEVGCDTIWEKDLNSHICYQFNLLSSLSWSEAHSSCQMQGGTLLSITDETEENFIREHMSSKTVEVWMGLNQLDEHAGWQWSDGTPLNYLNWSPEV... | Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 fun... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
BOP_PONAB | Pongo abelii | MPRGQCRQQGPRIPIWAAANYANAHPWQQMDQTSPGVAYTPLVDPWIERPCCGDTLCARTTMEQKSTASGACGGKPAERGPLTGRMPSSRPHRVDFCWVPGSDPGTFDGSPWLLDRFLAQLGDYMSFHFEHYQDNISRVCEILGRLTGQARAWAAPYLDGDLPLPDDYELFCQDLKEVVQDLNSFAEYHAVVPCPLPLASSQLPVASQLPVVKQYLARFLKGLALDMGTAPRSLPAAMATPAAFGSNSISRSALLEQQLTKESTPGPKEPPVLPSSACSSKPGPVEPASSQPEEAAPTPVPGLLESANPPAQRPDPAHPG... | Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation of RTL10/BOP activity (By similarity).
Subcellular locations: Mitochondrion | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TNF18_HUMAN | Homo sapiens | MCLSHLENMPLSHSRTQGAQRSSWKLWLFCSIVMLLFLCSFSWLIFIFLQLETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylat... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ABEC1_HUMAN | Homo sapiens | MTSEKGPSTGDPTLRRRIEPWEFDVFYDPRELRKEACLLYEIKWGMSRKIWRSSGKNTTNHVEVNFIKKFTSERDFHPSMSCSITWFLSWSPCWECSQAIREFLSRHPGVTLVIYVARLFWHMDQQNRQGLRDLVNSGVTIQIMRASEYYHCWRNFVNYPPGDEAHWPQYPPLWMMLYALELHCIILSLPPCLKISRRWQNHLTFFRLHLQNCHYQTIPPHILLATGLIHPSVAWR | Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs . Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA . A... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CLCKB_HUMAN | Homo sapiens | MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLL... | Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
Subcellular locations: Cell membrane
Expressed predominantly in the... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
EPHB4_HUMAN | Homo sapiens | MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPC... | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DHR13_HUMAN | Homo sapiens | MEALLLGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEEVPPAARDDRAAHRLWEASKRLAGLGPGEDAE... | Putative oxidoreductase.
Subcellular locations: Secreted | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
AL1A1_MACFA | Macaca fascicularis | MSSSGTSDLPVLPTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV... | Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid . Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CHCH9_HUMAN | Homo sapiens | MPRGSRSRTSRMAPPASRAPQMRAAPRPAPVAQPPAAAPPSAVGSSAAAPRQPGLMAQMATTAAGVAVGSAVGHTQGHAVTGGFSGGSNAEPARPDIAYQEPQGTQPAQQQQPCFYGIKQFLECAQNQGDIKLCEDFSKVLKQCRLAKGLA | Subcellular locations: Mitochondrion | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DPPA3_HUMAN | Homo sapiens | MDPSQFNPTYIPGSPQMLTEENSRDDSGASQISSETLIKNLSNLTINASSESVSPLSEALLRRESVGAAVLREIEDEWLYSRRGVRTLLSVQREKMARLRYMLLGGVRTHERRPTNKEPKGVKKESRPFKCPCSFCVSNGWDPSENARIGNQDTKPLQP | Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization . In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TIM13_HUMAN | Homo sapiens | MEGGFGSDFGGSGSGKLDPGLIMEQVKVQIAVANAQELLQRMTDKCFRKCIGKPGGSLDNSEQKCIAMCMDRYMDAWNTVSRAYNSRLQRERANM | Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Ac... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NTF3_HUMAN | Homo sapiens | MSILFYVIFLAYLRGIQGNNMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRYNSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRTSRRKRYAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT | Seems to promote the survival of visceral and proprioceptive sensory neurons.
Subcellular locations: Secreted
Brain and peripheral tissues. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TAD2B_HUMAN | Homo sapiens | MAELGKKYCVYCLAEVSPLRFRCTECQDIELCPECFSAGAEIGHHRRYHGYQLVDGGRFTLWGPEAEGGWTSREEQLLLDAIEQFGFGNWEDMAAHVGASRTPQEVMEHYVSMYIHGNLGKACIPDTIPNRVTDHTCPSGGPLSPSLTTPLPPLDISVAEQQQLGYMPLRDDYEIEYDQDAETLISGLSVNYDDDDVEIELKRAHVDMYVRKLKERQRRKNIARDYNLVPAFLGKDKKEKEKALKRKITKEEKELRLKLRPLYQFMSCKEFDDLFENMHKEKMLRAKIRELQRYRRNGITKMEESAEYEAARHKREKRKE... | Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.
Subcellular locations: Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CCD38_HUMAN | Homo sapiens | MSSNLLPTLNSGGKVKDGSTKEDRPYKIFFRDLFLVKENEMAAKETEKFMNRNMKVYQKTTFSSRMKSHSYLSQLAFYPKRSGRSFEKFGPGPAPIPRLIEGSDTKRTVHEFINDQRDRFLLEYALSTKRNTIKKFEKDIAMRERQLKKAEKKLQDDALAFEEFLRENDQRSVDALKMAAQETINKLQMTAELKKASMEVQAVKSEIAKTEFLLREYMKYGFFLLQMSPKHWQIQQALKRAQASKSKANIILPKILAKLSLHSSNKEGILEESGRTAVLSEDASQGRDSQGKPSRSLTRTPEKKKSNLAESFGSEDSLEF... | Subcellular locations: Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DUS4L_HUMAN | Homo sapiens | MKSDCMQTTICQERKKDPIEMFHSGQLVKVCAPMVRYSKLAFRTLVRKYSCDLCYTPMIVAADFVKSIKARDSEFTTNQGDCPLIVQFAANDARLLSDAARIVCPYANGIDINCGCPQRWAMAEGYGACLINKPELVQDMVKQVRNQVETPGFSVSIKIRIHDDLKRTVDLCQKAEATGVSWITVHGRTAEERHQPVHYDSIKIIKENMSIPVIANGDIRSLKEAENVWRITGTDGVMVARGLLANPAMFAGYEETPLKCIWDWVDIALELGTPYMCFHQHLMYMMEKITSRQEKRVFNALSSTSAIIDYLTDHYGI | Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
BRF2_MACFA | Macaca fascicularis | MPGRGRCPDCGSTELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTYSRSTGENEQISRSQQRGLRRVRDLCRVLQLPPTFEDTAVAYYQQAYRHSGIRAARLQKKEVLVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSIYMQIVKLLGLDMPSLCLAELVKTYCSSFKLFQASPSVPAKYVEDKEKMLSRTLQLVELANETWLVTGRHPLPVITAATFLAWQSLQPADRLSCSLARFCKLANVDLPYPASSRLQELLAVLLRMAEQLAWLRVLRLDKRSVVKHIGDLLQHRHSLVRLAFRDGTAEVE... | General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
COR1A_MACFA | Macaca fascicularis | MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGCDNVIMVWDVGTGAAVLTLGPEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKCTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFSRMSERQVALWGTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMG... | May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion.
Subcellular locations: Cytoplasm, Cytoskeleton, Cytoplasm, Cell cortex, Cytoplasmic vesicl... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DEN2D_HUMAN | Homo sapiens | MEGQVVGRVFRLFQRRLLQLRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDS... | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Subcellular locations: Cytoplasm
In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveo... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
GPC1_HUMAN | Homo sapiens | MELRARGWWLLCAAAALVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTW... | Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate si... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SRPK2_HUMAN | Homo sapiens | MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYC... | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing ( ). Promotes neuronal apoptosis by up-... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DFB4A_HUMAN | Homo sapiens | MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP | Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria (, ). Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM . Also exhibits antimicrobial activi... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PXDN_HUMAN | Homo sapiens | MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAK... | Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer ( , ). In turns, directly contributes ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SRSF6_HUMAN | Homo sapiens | MPRVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDEYEKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSNSPLPVPPSKARSVSPPPK... | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratin... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TNNI2_HUMAN | Homo sapiens | MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PRR14_HUMAN | Homo sapiens | MDLPGDSSPPGQPRLCRQPLTRALWGARSPKRPRLQLPGAPSPLEKASRRVLAVVLEDVMAVHMVPVVPSKQTSIPQHHSYHQDPVHRQPPASPPRQAGWSSQARPPDPLCLCREPLSRIHRTSSTLRRRSRTTPGPEEGPSQKVDRAPQPTLVVMLEDIASPRPPAEGFIDETPNFIIPAQRAEPMRIVRQPTPPPGDLEPPFQPSALPADPLESPPTAPDPALELPSTPPPSSLLRPRLSPWGLAPLFRSVRSKLESFADIFLTPNKTPQPPPPSPPMKLELKIAISEAEQSGAAEGTASVSPRPPIRQWRTQDHNTP... | Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha . Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit . Promotes myoblast differentiation during skeletal myogenesis,... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PROM2_HUMAN | Homo sapiens | MKHTLALLAPLLGLGLGLALSQLAAGATDCKFLGPAEHLTFTPAARARWLAPRVRAPGLLDSLYGTVRRFLSVVQLNPFPSELVKALLNELASVKVNEVVRYEAGYVVCAVIAGLYLLLVPTAGLCFCCCRCHRRCGGRVKTEHKALACERAALMVFLLLTTLLLLIGVVCAFVTNQRTHEQMGPSIEAMPETLLSLWGLVSDVPQELQAVAQQFSLPQEQVSEELDGVGVSIGSAIHTQLRSSVYPLLAAVGSLGQVLQVSVHHLQTLNATVVELQAGQQDLEPAIREHRDRLLELLQEARCQGDCAGALSWARTLELG... | Subcellular locations: Apical cell membrane, Basolateral cell membrane, Cell projection, Microvillus membrane, Cell projection, Cilium membrane
Colocalizes with PROM1. Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells (By similarity).
Prese... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CF120_MACFA | Macaca fascicularis | MAAPRGRAAPWTTALLLLLTSQILSPGSCADEEEVPEEWVLLHVVQGQIGAGNYSYLRLNHEGKIVLRMRSLKGDADLYVSASSLHPSFDDYELQSATCGPDAVSIPAHFRRPVGIGVYGHPSHLESEFEMKVYYDGTVEQHPFGEAAYPADGADAGQKHARAPEDASQEEESVLWTILISVLKLVLEILF | May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
Subcellular locations: Secreted
Secreted by hepatocytes. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CRTAP_HUMAN | Homo sapiens | MEPGRRGAAALLALLCVACALRAGRAQYERYSFRSFPRDELMPLESAYRHALDKYSGEHWAESVGYLEISLRLHRLLRDSEAFCHRNCSAAPQPEPAAGLASYPELRLFGGLLRRAHCLKRCKQGLPAFRQSQPSREVLADFQRREPYKFLQFAYFKANNLPKAIAAAHTFLLKHPDDEMMKRNMAYYKSLPGAEDYIKDLETKSYESLFIRAVRAYNGENWRTSITDMELALPDFFKAFYECLAACEGSREIKDFKDFYLSIADHYVEVLECKIQCEENLTPVIGGYPVEKFVATMYHYLQFAYYKLNDLKNAAPCAVS... | Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.
Subcellular locations: Secreted, Extracellular space, Extracellular matrix
Found in articular chondrocytes. Expressed in a variety of tissues. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
GDE1_HUMAN | Homo sapiens | MWLWEDQGGLLGPFSFLLLVLLLVTRSPVNACLLTGSLFVLLRVFSFEPVPSCRALQVLKPRDRISAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGIPVLMHDNTVDRTTDGTGRLCDLTFEQIRKLNPAANHRLRNDFPDEKIPTLREAVAECLNHNLTIFFDVKGHAHKATEALKKMYMEFPQLYNNSVVCSFLPEVIYKMRQTDRDVITALTHRPWSLSHTGDGKPRYDTFWKHFIFVMMDILLDWSMHNILWYLCGISAFLMQKDFVSPAYLKKWSAKGIQVVGWTVNTFDEKSYYESHLGSSYIT... | Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PAR3_HUMAN | Homo sapiens | MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNII... | Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
Subcellular locations: Cell membrane
Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
OTX2_HUMAN | Homo sapiens | MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL | Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Subcellular locations: Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
GRIA3_HUMAN | Homo sapiens | MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEA... | Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate ind... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
LIMK2_HUMAN | Homo sapiens | MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSS... | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (, ). Acts downstream of several Rho family GTPase signal transduction pathways (, ). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphor... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ZNF25_HUMAN | Homo sapiens | MNKFQGPVTLKDVIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVGYHVNKPNAVFKLKQGKEPWILEVEFPHRGFPEDLWSIHDLEARYQESQAGNSRNGELTKHQKTHTTEKACECKECGKFFCQKSALIVHQHTHSKGKSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYECKECKKIFYHLSSLSRHLRTHAGEKPYECNQCEKSFYQKPHLTEHQKTHTGEKPFECTECGKFFYVKAYLMVHQKTHTGEKPYECKECGKAFSQKSHLTVHQRMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYECKECR... | May be involved in transcriptional regulation.
Subcellular locations: Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
T2R16_PAPHA | Papio hamadryas | MIPIQLSVFFMIIYVLESLTIIVQSSLIVAVLGREWLQIRRLMPVDMILISLGISRFCLQWTSMLNDFCFYFNFNYVLCNLTITWTFFNVLTFWLNSLLTVFYCIKVSSFTHPIVLWLRWRILRWLPWLLLGCLMITCVTIIPSAIGNYIQIQFLTMEHPPRNSTVIDRLQKFHQYLHQAHTVALVIPFILFLASTILLMASLTKQIQHHGTGHCNPSMKAHFTALRSLAILFIVFTSYFLTILITMIGTLFDKRCWLWVWEAFVYAFIFMHSTSLMLSSPTLKRILNGKC | Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
Subcellu... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SYUA_HUMAN | Homo sapiens | MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release ( , ). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (, ). Mechanistically, ac... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MANS1_HUMAN | Homo sapiens | MFFGGEGSLTYTLVIICFLTLRLSASQNCLKKSLEDVVIDIQSSLSKGIRGNEPVYTSTQEDCINSCCSTKNISGDKACNLMIFDTRKTARQPNCYLFFCPNEEACPLKPAKGLMSYRIITDFPSLTRNLPSQELPQEDSLLHGQFSQAVTPLAHHHTDYSKPTDISWRDTLSQKFGSSDHLEKLFKMDEASAQLLAYKEKGHSQSSQFSSDQEIAHLLPENVSALPATVAVASPHTTSATPKPATLLPTNASVTPSGTSQPQLATTAPPVTTVTSQPPTTLISTVFTRAAATLQAMATTAVLTTTFQAPTDSKGSLETI... | Subcellular locations: Membrane
Widely expressed. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
BUB1_HUMAN | Homo sapiens | MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKKKYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASAVLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGNNMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKEKLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKLHQVVETSHEDLPASQERSEV... | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENP... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
B3GT9_HUMAN | Homo sapiens | MQVTFCRLRTHQWCFILFNVILFHALLFGTDFVEEYFLHSLPYIDVKVLEIKNKARKLNIEPLRSNLSKYYVLSQSEICKGKNIFLLSLIFSSPGNGTRRDLIRKTWGNVTSVQGHPILTLFALGMPVSVTTQKEINKESCKNNDIIEGIFLDSSENQTLKIIAMIQWAVAFCPNALFILKVDEETFVNLPSLVDYLLNLKEHLEDIYVGRVLHQVTPNRDPQNRDFVPLSEYPEKYYPDYCSGEAFIMSQDVARMMYVVFKEVPMMVPADVFVGICAKFIGLIPIHSSRFSGKRHIRYNRCCYKFIFTSSEIADPEMPL... | Putative glycosyltransferase that could catalyze the transfer of galactose residues from UDP-alpha-D-galactose.
Subcellular locations: Golgi apparatus membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
BL1S1_HUMAN | Homo sapiens | MAPGSRGERSSFRSRRGPGVPSPQPDVTMLSRLLKEHQAKQNERKELQEKRRREAITAATCLTEALVDHLNVGVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIELDMRTIATALEYVYKGQLQSAPS | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
LYRM4_HUMAN | Homo sapiens | MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQVHIGQLYSTDKLIIENRDMPRT | Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (, ). The core iron-sulfur cluster (ISC) assembly comple... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
RS15_PONAB | Pongo abelii | MAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK | Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular locations: Cytoplasm | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
FAH2A_HUMAN | Homo sapiens | MLVSGRRRLLTVLLQAQKWPFQPSRDMRLVQFRAPHLVGPHLGLETGNGGGVINLNAFDPTLPKTMTQFLEQGEATLSVARRALAAQLPVLPRSEVTFLAPVTRPDKVVCVGMNYVDHCKEQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELAVVIGKKGKHIKATDAMAHVAGFTVAHDVSARDWQMRRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVNGEVVQSGNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPPGVGVFRKPPVFLKKGDEVQCEIEELGVIINKVV | May have hydrolase activity. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
RBM11_HUMAN | Homo sapiens | MFPAQEEADRTVFVGNLEARVREEILYELFLQAGPLTKVTICKDREGKPKSFGFVCFKHPESVSYAIALLNGIRLYGRPINVQYRFGSSRSSEPANQSFESCVKINSHNYRNEEMLVGRSSFPMQYFPINNTSLPQEYFLFQKMQWHVYNPVLQLPYYEMTAPLPNSASVSSSLNHVPDLEAGPSSYKWTHQQPSDSDLYQMTAPLPNSASVSSSLNHVPDLEAGPSSYKWTHQQPSDSDLYQMNKRKRQKQTSDSDSSTDNNRGNECSQKFRKSKKKKRY | Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MFSD1_HUMAN | Homo sapiens | MEEEDEEARALLAGGPDEADRGAPAAPGALPALCDPSRLAHRLLVLLLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFFGGFLIDRVFGIRWGTIIFSCFVCIGQVVFALGGIFNAFWLMEFGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYSKIEALLGSAGHTTLGITLMIGGITCILSLICALALAYLDQRAERILHKEQGKTGEVIKLTDVKDFSLPLWLIFIICVCYYVAVFPFIGLGKVFFTEKFGFSSQAASAINSVVYVISAPMSPVF... | Lysosomal transporter which is essential for liver homeostasis. Required to maintain stability and lysosomal localization of GLMP.
Subcellular locations: Lysosome membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SPCS2_HUMAN | Homo sapiens | MAAAAVQGGRSGGSGGCSGAGGASNCGTGSGRSGLLDKWKIDDKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK | Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum . Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocati... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
LRP5_HUMAN | Homo sapiens | MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYT... | Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins ( , ). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (, ). In particul... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
RFPL3_HUMAN | Homo sapiens | MKRLSLVTTNRLSPQGNFLPLCTFPLAVDMAALFQEASSCPVCSDYLEKPMSLECGCTVCLKCINSLQKEPHGEDLLCCCCSMVSQRNKIRPNRQLERLVSHIKELEPKLKKILQMNPRMRKFQVDMTLDADTANNFLLISDDLRSVRSGLITQNRQDLAERFDVSVCILGSPRFTCGRHYWEVDVGTSTEWDLGVCRESVHCKGKIQLTTELGFWTVSLRDGSRLSASTVPLTFLLVDRKLQRVGIFLDMGMQNVSFFDAESGSHVYTFRSVSAEEPLRPFLAPSIPPNGDQGVLSICPLMNSGTTDAPVRPGEAK | (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.
Subcellular locations: Cytoplasm, Nucleus
A higher concentration of RFPL3 is observed in the cytoplasm compared to the nucleus.
Expressed during neurogenesis in differentiating human embryonic stem cells and i... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
APOB_HUMAN | Homo sapiens | MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLFLDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPK... | Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
Subcellular locations: Cytoplasm, Secreted, Lipid droplet | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
UBR5_HUMAN | Homo sapiens | MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRER... | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
VACHT_MACFU | Macaca fuscata fuscata | GMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFD | Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
STK4_MACMU | Macaca mulatta | METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENS... | Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MO4L1_PONAB | Pongo abelii | MAPKQDPKPKFQEGERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHHSGWNKNWDEWVPESRVLKYVDTNLQKQRELQKANQEQYAEGKMRGAAPGKKTSGLQQKNVDVKTKKNKQKTPGNGDGGSTSETPQPPRKKRARVDPTVENEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSRGNTDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILADHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLNYLHDFLKYLAKNSATLFSASDYEVAPPEYHR... | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CAV1_PONAB | Pongo abelii | MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMAEELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPLFEAVGKIFSNVRINLQKEI | Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha s... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DB123_GORGO | Gorilla gorilla gorilla | MKLLLLTLTVLLLLSQLTPGGTQRCWNLYGKCRYRCSKKERVYVYCINNKMCCVKPKYQPKERWWPF | Has antibacterial activity.
Subcellular locations: Secreted | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ZN582_HUMAN | Homo sapiens | MSLGSELFRDVAIVFSQEEWQWLAPAQRDLYRDVMLETYSNLVSLGLAVSKPDVISFLEQGKEPWMVERVVSGGLCPVLESRYDTKELFPKQHVYEVESPQWEIMESLTSYGLECSSFQDDWECRNQFDRQQGNPDRHFHQMIIRHEEMPTFDQHASLTFYQKIHTREKPFGYNKCRKDFWQKELLINHQGIYTNEKPYKCKECGKAFKYGSRLIQHENIHSGKKPYECKECGKAFNSGSNFIQHQRVHTGEKPYECKDCEKAFSRSSQLIEHQRTHTGEKPYQCKECGKAFNRISHLKVHYRIHTGEKPYACKECGKTF... | May be involved in transcriptional regulation.
Subcellular locations: Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SNX21_HUMAN | Homo sapiens | MHRGTQEGAMASRLLHRLRHALAGDGPGEAAASPEAEQFPESSELEDDDAEGLSSRLSGTLSFTSAEDDEDDEDEDDEEAGPDQLPLGDGTSGEDAERSPPPDGQWGSQLLARQLQDFWKKSRNTLAPQRLLFEVTSANVVKDPPSKYVLYTLAVIGPGPPDCQPAQISRRYSDFERLHRNLQRQFRGPMAAISFPRKRLRRNFTAETIARRSRAFEQFLGHLQAVPELRHAPDLQDFFVLPELRRAQSLTCTGLYREALALWANAWQLQAQLGTPSGPDRPLLTLAGLAVCHQELEDPGEARACCEKALQLLGDKSLHP... | Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking.
Subcellular locations: Cytoplasmic vesicle membrane, Early endosome membrane
Highly expressed in fetus liver, but only weakly expressed ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CFTR_MACNE | Macaca nemestrina | MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSADSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGILLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIVPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKINERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFL... | Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
FA20A_HUMAN | Homo sapiens | MPGLRRDRLLTLLLLGALLSADLYFHLWPQVQRQLRPRERPRGCPCTGRASSLARDSAAAASDPGTIVHNFSRTEPRTEPAGGSHSGSSSKLQALFAHPLYNVPEEPPLLGAEDSLLASQEALRYYRRKVARWNRRHKMYREQMNLTSLDPPLQLRLEASWVQFHLGINRHGLYSRSSPVVSKLLQDMRHFPTISADYSQDEKALLGACDCTQIVKPSGVHLKLVLRFSDFGKAMFKPMRQQRDEETPVDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGRIVNVTKEILEVTKNEILQSVFFVSPASNVCFFAKCP... | Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals.
Sub... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
COF1_MACFA | Macaca fascicularis | MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPECAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL | Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (By similarity). Important for normal progress through mitosis and normal cytokinesis (By similarity). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell d... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NDUV3_HUMAN | Homo sapiens | MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKKPAPVPAEPFDNTTYKNLQHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
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