protein_name stringlengths 7 11 | species stringclasses 219
values | sequence stringlengths 2 34.4k | annotation stringlengths 6 11.5k | messages listlengths 3 3 |
|---|---|---|---|---|
NEUR2_HUMAN | Homo sapiens | MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEA... | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (, ). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
GPD1L_PONAB | Pongo abelii | MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAISNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDK... | Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) b... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
FBX15_HUMAN | Homo sapiens | MATGRGRILQQHWLGLQTLRGPSRGGGAARGRARAFGCRKGPGVKLSAGSAALRCHAGGGQHWESSFSCCSGFLDGMPSEILLKIFSYLDAVSLLCTGCVSRRFYHLANDNFIWIGIYSTAFSPARSNWKFNSVEKIAMSMSFLSVQDKEAGYWKKEYITKQIASVKAALADILKPVNPYTGLPVKTKEALRIFGLGWAIILKEKGGKEYIMEHVDLSINDTSVTVIWYGKKWPCLASLSTLDLCGMTPVFTDWYKTPTKHRLRWHSLIAKYNLSHLTISTMIGCDRLIRIFCLHPGLLVGVWKKEEELAFVMANLHFHH... | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
GPX4_PONPY | Pongo pygmaeus | MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF | Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidativ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ODC_PONAB | Pongo abelii | MSAKPEVGLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQTERLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFTIAGLGSGLTEAIVVNPFEVVKVGLQANRNTFAKQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPTLEFLRKFGIGLLSGTIASVINIPFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW | Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioa... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
AT8B1_HUMAN | Homo sapiens | MSTERDSETTFDEDSQPNDEVVPYSDDETEDELDDQGSAVEPEQNRVNREAEENREPFRKECTWQVKANDRKYHEQPHFMNTKFLCIKESKYANNAIKTYKYNAFTFIPMNLFEQFKRAANLYFLALLILQAVPQISTLAWYTTLVPLLVVLGVTAIKDLVDDVARHKMDKEINNRTCEVIKDGRFKVAKWKEIQVGDVIRLKKNDFVPADILLLSSSEPNSLCYVETAELDGETNLKFKMSLEITDQYLQREDTLATFDGFIECEEPNNRLDKFTGTLFWRNTSFPLDADKILLRGCVIRNTDFCHGLVIFAGADTKIM... | Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (, ). May participate in the establishment of the canalicular membrane integrity by ens... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CC163_HUMAN | Homo sapiens | MNTSLSWFEQLDVLLNATDGNVVRNKQWLYPLGVSTELIGLCICFFCSSGCIFLGSPPQNSTAVTPAVLWEESEIMQKELKLLQYQLSQHQELLLKQLAEGRQAQVGSWKIPRGAPFLTWSPASFSSMPRVLSKRTYSFGAPKCS | Subcellular locations: Membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NEUM_MACFA | Macaca fascicularis | MLCCMRRTKQVEKNDEDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDAQAAEAEANKKDEAPVADGVEKKGEGTTATEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA | This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
Subcellular locations: Cell membrane, Cell projection, Growth cone membrane, Synapse, Cell projection, Filo... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
STAM1_HUMAN | Homo sapiens | MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQVETIEPEPEPAFIDEDKMDQLLQMLQSTDPS... | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PSME4_HUMAN | Homo sapiens | MEPAERAGVGEPPEPGGRPEPGPRGFVPQKEIVYNKLLPYAERLDAESDLQLAQIKCNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRADLELPWRPLYDMVERILYSKTEHLGLNWFPNSVENILKTLVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAITYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMG... | Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SALL1_HUMAN | Homo sapiens | MSRRKQAKPQHFQSDPEVASLPRRDGDTEKGQPSRPTKSKDAHVCGRCCAEFFELSDLLLHKKNCTKNQLVLIVNENPASPPETFSPSPPPDNPDEQMNDTVNKTDQVDCSDLSEHNGLDREESMEVEAPVANKSGSGTSSGSHSSTAPSSSSSSSSSSGGGGSSSTGTSAITTSLPQLGDLTTLGNFSVINSNVIIENLQSTKVAVAQFSQEARCGGASGGKLAVPALMEQLLALQQQQIHQLQLIEQIRHQILLLASQNADLPTSSSPSQGTLRTSANPLSTLSSHLSQQLAAAAGLAQSLASQSASISGVKQLPPIQ... | Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development.
Subcellular locations: Nucleus
Highest levels in kidney. Lower levels in adult brain (enriched in corpus callosum, lower expression in substantia nigra) and liver. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NETR_MACMU | Macaca mulatta | MTLARFVLALVLGALPEVVGFDSVLNDSFHHRHRHSPPPGPQYPYYLPTHQRPPRTRPPPPLPRFPRPPRALPAQRPHALQAGHTPRPHPWGCPAGELWVSVTDFGAPCLRWAEVPPFLERSPPANWAQLRGQRHNFCRSPDGTGRPWCFYGDARGKVDWGYCDCRHGSVRLRGGKNEFEGTVEVYASGAWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSRGPAFPIIRLVGGSSVHEGRVELYHAGQWGTICDDQWDDADAEVICRQ... | Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
Subcellular locations: Secreted | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ORAI2_HUMAN | Homo sapiens | MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL | Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
Subcellular locations: Membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
HBE_CEBOL | Cebus olivaceus | MVHFTAEEKVAITSLWSKMNVEEAGGEALGRLLVVYPWTQRFFDNFGNLSSPSAILGNPKVKAHGKKVLTSFGDAIKNMDNLKTTFAKLSELHCDKLHVDPENFRLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAIALGHKYH | The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.
Red blood cells. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
HBA_ATEGE | Ateles geoffroyi | MVLSPADKSNVKAAWGKVGGHAGDYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHHPADFTPAVHASLDKFLASVSTVLTSKYR | Involved in oxygen transport from the lung to the various peripheral tissues.
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
Red blood cells. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
RM12_HUMAN | Homo sapiens | MLPAAARPLWGPCLGLRAAAFRLARRQVPCVCAVRHMRSSGHQRCEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLVPMGGVMSGAVPAAAAQEAVEEDIPIAKERTHFTVRLTEAKPVDKVKLIKEIKNYIQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE | As a component of the mitochondrial large ribosomal subunit, it plays a role in mitochondrial translation . Associates with mitochondrial RNA polymerase to activate transcription.
Subcellular locations: Mitochondrion matrix | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TRIM9_HUMAN | Homo sapiens | MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSHRAAGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPATHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQC... | E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorde... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
APTX_HUMAN | Homo sapiens | MSNVNLSVSDFWRVMMRVCWLVRQDSRHQRIRLPHLEAVVIGRGPETKITDKKCSRQQVQLKAECNKGYVKVKQVGVNPTSIDSVVIGKDQEVKLQPGQVLHMVNELYPYIVEFEEEAKNPGLETHRKRKRSGNSDSIERDAAQEAEAGTGLEPGSNSGQCSVPLKKGKDAPIKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVR... | DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair ( ). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (, ). Catalyzes t... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
OR1E3_HUMAN | Homo sapiens | MMKKNQTMISEFLLLGLPIQPEQQNLFYALFLAVYLTTLLGNLLVIVLIRLDSHLHMPMYLCLSNLSFSDLCFSSVTMPKLLQNMQSQNPSIPFADCLAQMYFHLFYGVLESFLLVVMAYHCYVAICFPLHYTTIMSPKCCLGLLTLSWLLTTAHATLHTLLMARLSFCAENVIPHFFCDTSTLLKLACSNTQVNGWVMFFMGGLILVIPFLLLIMSCARIVSTILRVPSTGGIQKAFSTCGPHLSVVSLFYGTIIGLYLCPLTNHNTVKDTVMAVMYTGVTHMLNPFIYSLRNRDMRGNPGQSLQHKENFFVFKIVIVG... | Odorant receptor.
Subcellular locations: Cell membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MORN3_MACFA | Macaca fascicularis | MPVSKCPKKSESLWKGWDRKAQKNGLRRQVYAVNGDYYVGEWKDNVKHGKGTQVWKKNGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGEWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGDGMLRLKNGNRYEGCWERGMKNGLGRFFHLDHGQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQFPIPEVKILDPDGVLAQALAMFKKTEEGD | Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors (By simil... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TM225_HUMAN | Homo sapiens | MVHVSNRSIQGMNILFSSWAVVLMVMGITLDKWVELISEDERAKMNHSPWMMCCPALWPEDDLKVVRIMMTSSLGLSFLLNLILGMKFTYLIPQNKYIQLFTTILSFFSGISLLWALILYHNKLKQGQSMHFSSYRITWIMYTAYLNVFFLSVCGVLSLLECKLSTSSCTCLNIHKSDNECKESENSIEDISLPECTAMPRSIVRAHTVNSLNKKVQTRHVTWAL | Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.
Subcellular locations: Cytoplasmic vesicle, Secretory vesicle, Acrosome membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DTNB_HUMAN | Homo sapiens | MIEESGNKRKTMAEKRQLFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNLHLVDIWNMIEAFRDNGLNTLDHTTEISVSRLETVISSIYYQLNKRLPSTHQISVEQSISLLLNFMIAAYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRYVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVFHPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVF... | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NAPSA_HUMAN | Homo sapiens | MSPPPLLQPLLLLLPLLNVEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYIILCSEI... | May be involved in processing of pneumocyte surfactant precursors.
Subcellular locations: Secreted
Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CDHR3_HUMAN | Homo sapiens | MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDR... | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
(Microbial infection) Acts as a receptor for human rhinovirus C.
Subcellular locations: Cell membrane... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CNTN6_HUMAN | Homo sapiens | MRLLWKLVILLPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEW... | Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
HEXI1_HUMAN | Homo sapiens | MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDA... | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor ( ). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation ( , ).... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ADA28_HUMAN | Homo sapiens | MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSV... | May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
Subcellular locations: Cell membrane
Subcellular locations: Secreted
Expressed predomi... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
HPT_PONAB | Pongo abelii | MSALGAVIALLLWGQLFAVDSGNDVMDISDDGCPKPPQIAHGYVEHSVRYQCKNYYRLRTEGDGVYTLNSEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSRHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVPVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTEHLKYVMLPVADQDQCVRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILSFDK... | As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a rol... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
WT1_HUMAN | Homo sapiens | MGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEK... | Transcription factor that plays an important role in cellular development and cell survival . Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' ( ). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CAN2_MACFA | Macaca fascicularis | MAGIAAKLVKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITYQKLVKGHAYSVTGAEEVESSGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHE... | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, le... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CYB_LEPSH | Lepilemur sahamalazensis | MTNTRKNHPLLKIINNSLIDLPTPPNISSLWNFGSLLGACLTIQIITGLFLAMHYTADTMTAFSSVAHICRDVNYGWTIRYLHANGASMFFLCLFIHVGRGLYYGSFTLLETWNVGITLLFSVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGTDLVEWIWGGFSVGKATLTRFFALHFILPFITSALVMIHLLFLHETGSNNPLGVPSNSDKIPFHPYYTTKDFLGLLLLILLLMTMALFYPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVMALILSILILVMFPFLQPNKQQTMMFRPL... | Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
FIBA_MACFA | Macaca fascicularis | ADTGEGDFLAEGGGVR | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repa... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
JMJD7_HUMAN | Homo sapiens | MAEAALEAVRSELREFPAAARELCVPLAVPYLDKPPTPLHFYRDWVCPNRPCIIRNALQHWPALQKWSLPYFRATVGSTEVSVAVTPDGYADAVRGDRFMMPAERRLPLSFVLDVLEGRAQHPGVLYVQKQCSNLPSELPQLLPDLESHVPWASEALGKMPDAVNFWLGEAAAVTSLHKDHYENLYCVVSGEKHFLFHPPSDRPFIPYELYTPATYQLTEEGTFKVVDEEAMEKVPWIPLDPLAPDLARYPSYSQAQALRCTVRAGEMLYLPALWFHHVQQSQGCIAVNFWYDMEYDLKYSYFQLLDSLTKASGLD | Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase (, ). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation . Preferentially rec... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SMIM6_HUMAN | Homo sapiens | MDQLVFKETIWNDAFWQNPWDQGGLAVIILFITAVLLLILFAIVFGLLTSTENTQCEAGEEE | Subcellular locations: Membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
EIF3G_HUMAN | Homo sapiens | MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSPEPELLPGAPLPPPKEVINGNIKTVTEYKIDEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQATQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis ( ). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NPT2B_HUMAN | Homo sapiens | MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTA... | Involved in actively transporting phosphate into cells via Na(+) cotransport.
Subcellular locations: Apical cell membrane
Localized at the brush border membranes of enterocytes.
Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ITB8_HUMAN | Homo sapiens | MCGSALAFFTAAFVCLQNDRRGPASFLWAAWVFSLVLGLGQGEDNRCASSNAASCARCLALGPECGWCVQEDFISGGSRSERCDIVSNLISKGCSVDSIEYPSVHVIIPTENEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLVDVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIHPERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNVYVKSTTM... | Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin . It recognizes the sequence R-G-D in its ligands . Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CNKR2_HUMAN | Homo sapiens | MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQP... | May function as an adapter protein or regulator of Ras signaling pathways.
Subcellular locations: Cytoplasm, Membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
RSSA_CHLAE | Chlorocebus aethiops | MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTEWS | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
HUS1B_HUMAN | Homo sapiens | MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLWCEVRQGAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFLEGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIPAL | Expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SSRD_HUMAN | Homo sapiens | MAAMASLGALALLLLSSLSRCSAEACLEPQITPSYYTTSDAVISTETVFIVEISLTCKNRVQNMALYADVGGKQFPVTRGQDVGRYQVSWSLDHKSAHAGTYEVRFFDEESYSLLRKAQRNNEDISIIPPLFTVSVDHRGTWNGPWVSTEVLAAAIGLVIYYLAFSAKSHIQA | TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
Subcellular locations: Endoplasmic reticulum membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CNO10_MACFA | Macaca fascicularis | MAADKPADQGAEKHEGTGQSSGITDQEKELSTNAFQAFTSGNYDACLQHLACLQDINKDDYKIILNTAVAEFFKSNQTTTDNLRQTLNQLKNQVHSAVEEMDGLDDVENSMLYYNQAVILYHLRQYTEAISVGEKLYQFIEPFEEKFAQAVCFLLVDLYILTYQAEKALHLLAVLEKMISQGNNNKNGKNETGNNNNKDGSNHKAESGALIEAAKSKIHQYIVRAYIQMKSLKACKREIKSVMNTAGNSAPSLFLKSNFEYLRGNYRKAVKLLNSSNIAEHPGFMKTGECLRCMFWNNLGCIHFAMSKHNLGIFYFKKAL... | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may b... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MAK16_HUMAN | Homo sapiens | MQSDDVIWDTLGNKQFCSFKIRTKTQSFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLSKNYEKALEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRQRKLVPLSKKVERREKRREEKALIAAQLDNAIEKELLERLKQDTYGDIYNFPIHAFDKALEQQEAESDSSDTEEKDDDDDDEEDVGKREFVEDGEVDESDISDFEDMDKLDASSDEDQDGKSSSEEEEEKALSAKHKGKMPLRGPLQRKRAYVEIEYEQETEPVAKAKTT | Subcellular locations: Nucleus, Nucleolus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
KR134_MACFA | Macaca fascicularis | MSYNCCSGNFSSRSFGGYLHYPGCNPYSTALCSPSICQLGSSLYRNCQKTCWEPTSCRKSCYRRRTSMLCSPCQTTCSRSLGFGSSSCHSQGYGSRSCYSLGSGSSGFRFLKYGGCGFPSLSYGSRFCYPNYLASRAWQSSCYRPICGSRFYQFTC | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of ha... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ZN266_HUMAN | Homo sapiens | MLENYKNLATVGYQLFKPSLISWLEQEESRTVQRGDFQASEWKVQLKTKELALQQDVLGEPTSSGIQMIGSHNGGEVSDVKQCGDVSSEHSCLKTHVRTQNSENTFECYLYGVDFLTLHKKTSTGEQRSVFSQCGKAFSLNPDVVCQRTCTGEKAFDCSDSGKSFINHSHLQGHLRTHNGESLHEWKECGRGFIHSTDLAVRIQTHRSEKPYKCKECGKGFRYSAYLNIHMGTHTGDNPYECKECGKAFTRSCQLTQHRKTHTGEKPYKCKDCGRAFTVSSCLSQHMKIHVGEKPYECKECGIAFTRSSQLTEHLKTHTA... | May be involved in transcriptional regulation.
Subcellular locations: Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
RT06_HUMAN | Homo sapiens | MPRYELALILKAMQRPETAATLKRTIEALMDRGAIVRDLENLGERALPYRISAHSQQHNRGGYFLVDFYAPTAAVESMVEHLSRDIDVIRGNIVKHPLTQELKECEGIVPVPLAEKLYSTKKRKK | Subcellular locations: Mitochondrion | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CEP83_HUMAN | Homo sapiens | MVVSTFTDMDTFPNNFPPGGDSGLTGSQSEFQKMLIDERLRCEHHKANYQTLKAEHTRLQNEHVKLQNELKHLFNEKQTQQEKLQLLLEELRGELVEKTKDLEEMKLQILTPQKLELLRAQIQQELETPMRERFRNLDEEVEKYRAVYNKLRYEHTFLKSEFEHQKEEYARILDEGKIKYESEIARLEEDKEELRNQLLNVDLTKDSKRVEQLAREKVYLCQKLKGLEAEVAELKAEKENSEAQVENAQRIQVRQLAEMQATVRSLEAEKQSANLRAERLEKELQSSSEQNTFLINKLHKAEREINTLSSKVKELKHSNK... | Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly.
Subcellular locations: Cytoplasm, Cytoskeleto... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
T200A_HUMAN | Homo sapiens | MIATGGVITGLAALKRQDSARSQQHVNLSPSPATQEKKPIRRRPRADVVVVRGKIRLYSPSGFFLILGVLISIIGIAMAVLGYWPQKEHFIDAETTLSTNETQVIRNEGGVVVRFFEQHLHSDKMKMLGPFTMGIGIFIFICANAILHENRDKETKIIHMRDIYSTVIDIHTLRIKEQRQMNGMYTGLMGETEVKQNGSSCASRLAANTIASFSGFRSSFRMDSSVEEDELMLNEGKSSGHLMPPLLSDSSVSVFGLYPPPSKTTDDKTSGSKKCETKSIVSSSISAFTLPVIKLNNCVIDEPSIDNITEDADNLKSRSR... | Subcellular locations: Membrane
Expressed in cerebellum. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ELAV2_PONAB | Pongo abelii | METQLSNGPTCNNTANGPTTINNNCSSPVDSGNTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKTNQAILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKRFSPMTIDGMTSLAGINIPGHPGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFG... | RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity). | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CAH14_HUMAN | Homo sapiens | MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRL... | Reversible hydration of carbon dioxide.
Subcellular locations: Membrane
High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
NU5M_PONAB | Pongo abelii | MAMFTTMTALTLTSLIPPITATLINPNKKNSYPHYVKTAIASAFTISLIPTTMFICLGQETIVTNWCWTTTQTLQLSLSFKLDYFSMTFLPVALLITWSIMEFSLWYMASDPNINQFLKFLLIFLITMIILVTANNLLQLFIGWEGVGIMSFLLISWWYARTDANTAAIQAILYNRIGDIGFILALAWFLLHSNSWELQQVFLLNNNPNLLPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFHPLTENSPHIQTLTLCLGAITTLFAAICALTQNDIKKIVAFSTSSQLGLMMVTIGIN... | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Subcellular locations: Mitochondrion inner memb... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ADCK2_HUMAN | Homo sapiens | MVAPWRVSVRVCLSHLRCFELRQGLSLLRPSECPRDARLCWLLLGTLPKVVSLCGDVGEGAPDVLSRRRVRCSGAAGAGPAESLPRAGPLGGVFLHLRLWLRAGALLVKFFPLLLLYPLTYLAPSVSTLWLHLLLKATETSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWTHTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYANTAFLETDSVQRLGRASCLPPFSHTGAVGGLRELFGYLGNGRKPPENLADQSFLERLLLPKADLVGSNAGVSRAQVPGHQPEATNLISVAVKVLHPGLLAQ... | The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). Involved in the mitochondrial import of CoQ precursors, plays a role in muscle mitochondrial function and fatty acid beta-oxidation .
Subcellul... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CCR5_MANLE | Mandrillus leucophaeus | MDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNIMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPYSQYQFWKNFRTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRF... | Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migrati... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MMP20_HUMAN | Homo sapiens | MKVLPASGLAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIF... | Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site.
Subcell... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MAP2_HUMAN | Homo sapiens | MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTY... | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two ord... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
UB2Q1_HUMAN | Homo sapiens | MQQPQPQGQQQPGPGQQLGGQGAAPGAGGGPGGGPGPGPCLRRELKLLESIFHRGHERFRIASACLDELSCEFLLAGAGGAGAGAAPGPHLPPRGSVPGDPVRIHCNITESYPAVPPIWSVESDDPNLAAVLERLVDIKKGNTLLLQHLKRIISDLCKLYNLPQHPDVEMLDQPLPAEQCTQEDVSSEDEDEEMPEDTEDLDHYEMKEEEPAEGKKSEDDGIGKENLAILEKIKKNQRQDYLNGAVSGSVQATDRLMKELRDIYRSQSFKGGNYAVELVNDSLYDWNVKLLKVDQDSALHNDLQILKEKEGADFILLNFS... | Catalyzes the covalent attachment of ubiquitin to other proteins . May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity).
Subcellular locations: Nucleus, Cell projection, Filopo... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PKHM1_HUMAN | Homo sapiens | MLSVVENGLDPQAAIPVIKKKLVGSVKALQKQYVSLDTVVTSEDGDANTMCSALEAVFIHGLHAKHIRAEAGGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGRCRAWLRLALNDGLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFELSYKSAILNEWTLTPLALSGLCPLSELDPLSTSGAELQRKESLDSISHSSGSEDIEVHHSGHKIRRNQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDSDLGTANAEDSDRSLQEVLLEFSKAQVNS... | Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ZNG1C_HUMAN | Homo sapiens | MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLV... | Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-term... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
GALR3_HUMAN | Homo sapiens | MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRAL... | Receptor for the hormone galanin . Receptor for the hormone spexin-1 .
Subcellular locations: Cell membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
HV169_HUMAN | Homo sapiens | MDWTWRFLFVVAAATGVQSQVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPIFGTANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCAR | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as recep... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MED30_HUMAN | Homo sapiens | MSTPPLAASGMAPGPFAGPQAQQAAREVNTASLCRIGQETVQDIVYRTMEIFQLLRNMQLPNGVTYHTGTYQDRLTKLQDNLRQLSVLFRKLRLVYDKCNENCGGMDPIPVEQLIPYVEEDGSKNDDRAGPPRFASEERREIAEVNKKLKQKNQQLKQIMDQLRNLIWDINAMLAMRN | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
COLL1_HUMAN | Homo sapiens | MMLPQWLLLLFLLFFFLFLLTRGSLSPTKYNLLELKESCIRNQDCETGCCQRAPDNCESHCAEKGSEGSLCQTQVFFGQYRACPCLRNLTCIYSKNEKWLSIAYGRCQKIGRQKLAKKMFF | Subcellular locations: Secreted
Exclusively expressed in epididymis, in the corpus region. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SLAI2_HUMAN | Homo sapiens | MEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLSAKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELD... | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.
Subcellular locations: Cytoplasm, Cytoskeleton
Colocalizes with microtubules... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DEF2_MACMU | Macaca mulatta | ACYCRIPACLAGERRYGTCFYMGRVWAFCC | Has bacteriostatic activity against L.monocytogenes, E.coli and S.aureus, microbicidial activity against L.monocytogenes and S.aureus and antifungal activity against C.neoformans.
Subcellular locations: Secreted | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TVB76_HUMAN | Homo sapiens | MGTSLLCWVVLGFLGTDHTGAGVSQSPRYKVTKRGQDVALRCDPISGHVSLYWYRQALGQGPEFLTYFNYEAQQDKSGLPNDRFSAERPEGSISTLTIQRTEQRDSAMYRCASSL | V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (p... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PKNX1_HUMAN | Homo sapiens | MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQP... | Activates transcription in the presence of PBX1A and HOXA1.
Subcellular locations: Nucleus
Ubiquitous. Isoform 2 is expressed in all examined tissues except in bone marrow. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TNF14_HUMAN | Homo sapiens | MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV | Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (, ). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production .
Subcellular locations: Cell membrane
Subcellular loc... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ABC3H_HUMAN | Homo sapiens | MALLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKKCHAEICFINEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLGIFASRLYYHWCKPQQKGLRLLCGSQVPVEVMGFPEFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLERIKIPGVRAQGRYMDILCDAEV | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells o... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
RING1_HUMAN | Homo sapiens | MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGEGDGEDVSSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQEAGEPGGPG... | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation o... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
HIG1A_HUMAN | Homo sapiens | MSTDTGVSLPSYEEDQGSKLIRKAKEAPFVPVGIAGFAAIVAYGLYKLKSRGNTKMSIHLIHMRVAAQGFVVGAMTVGMGYSMYREFWAKPKP | Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes.
Subcellular locations: Mitochondrion membrane, Mitochondrion inner membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SYSC_MACFA | Macaca fascicularis | MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVEDDESVPENVLNFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDADNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYTPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQ... | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted int... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CLD17_HUMAN | Homo sapiens | MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV | Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability.
Subcellular locations: Cell jun... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TZAP_PONAB | Pongo abelii | MDGSFVQHSVRVLQELNKQREKGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQSFKPKISVGQAAGGQSGQGPPASQNVNSHVKEPAGLEEEEVSRTLGLVPRDQEPRGSHSPQRPKLHSLAQSESPSSLCGKLKQASKPCPPEDKKLEDCKVLPRPFEAEGAQLQGGSNEWEVVVQVEDDGDGDYMSEPEAVLTRRKSNVIRKPCAAEPALNAGSLAAEPAENRKGTAVPVECPTCHKKFLSKYYLKVHNRKHTGEKPFE... | Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CLC4G_HUMAN | Homo sapiens | MDTTRYSKWGGSSEEVPGGPWGRWVHWSRRPLFLALAVLVTTVLWAVILSILLSKASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQLQTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQNNSCEPCPTSWLSFEGSCYFFSVPKTTWAAAQDHCADASAHLVIVGGLDEQGFLTRNTRGRGYWLGLRAVRHLGKVQGYQWVDGVSLSFSHWNQGEPNDAWGRENCVMMLHTGLWNDAPCDSEKDGWICEKRHNC | Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.
(Microbial infection) Acts as a receptor for Japanese encephalitis virus.
(Microbial infection) Acts as a receptor for Ebolavirus.
(Microbial infection) Acts as a receptor for SARS-CoV.
(Microbial infectio... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SIGL8_HUMAN | Homo sapiens | MLLLLLLLPLLWGTKGMEGDRQYGDGYLLQVQELVTVQEGLCVHVPCSFSYPQDGWTDSDPVHGYWFRAGDRPYQDAPVATNNPDREVQAETQGRFQLLGDIWSNDCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGTLESGHSRNLTCSVPWACKQGTPPMISWIGASVSSPGPTTARSSVLTLTPKPQDHGTSLTCQVTLPGTGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNPPARLSWTRGSLTLCPSRSSNPGLLELPRVHV... | Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (, ). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface . Recognizes sim... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DHX40_PONAB | Pongo abelii | MSRFPAVAGRAPRRQEEGERSRDLQEERPSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYG... | Probable ATP-dependent RNA helicase. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
DJC24_HUMAN | Homo sapiens | MMAVEQMPKKDWYSILGADPSANISDLKQKYQKLILMYHPDKQSTDVPAGTVEECVQKFIEIDQAWKILGNEETKREYDLQRCEDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYN | Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MD2L1_HUMAN | Homo sapiens | MALQLSREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLVTTDLELIKYLNNVVEQLKDWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKDDSAPREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNSEEVRLRSFTTTIHKVNSMVAYKIPVND | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (, ). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CTTB2_AOTNA | Aotus nancymaae | MATDGASCEPDLSRAPEDAAGAAAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCRKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLATRLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELCAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMKKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTESADHVK... | Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
Subcellular locations: Cytoplasm, Cell cortex, Cell projection, Dendritic spine
Remains associated with dendritic spines even after glutamate stimulation. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PCDH9_HUMAN | Homo sapiens | MDLRDFYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDR... | Potential calcium-dependent cell-adhesion protein.
Subcellular locations: Cell membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SLIT1_HUMAN | Homo sapiens | MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNG... | Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
APC13_PONAB | Pongo abelii | MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPDPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'L... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ZN223_HUMAN | Homo sapiens | MTMSKEAVTFKDVAVVFTEEELGLLDLAQRKLYRDVMLENFRNLLSVGHQPFHRDTFHFLREEKFWMMDIATQREGNSGGKIQPEMKTFPEAGPHEGWSCQQIWEEIASDLTRPQDSTIKSSQFFEQGDAHSQVEEGLSIMHTGQKPSNCGKCKQSFSDMSIFDLPQQIRSAEKSHSCDECGKSFCYISALHIHQRVHLGEKLFKCDVCGKEFSQSLHLQTHQRVHTGEKPFKCEQCGRGFRCRSALTVHCKLHMGEKHYNCEACGRAFIHDFQLQKHQRIHTGEKPFKCEICSVSFRLRSSLNRHCVVHTGKKPNSTGE... | May be involved in transcriptional regulation.
Subcellular locations: Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PAX9_LEMCA | Lemur catta | MEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLAQQGHYDSYKQHQPAPQPALPYNHIYSYPSPITAAAAKVPTPPGVPAIPGSVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLGRNNFPAAAPHAVNGLEKGALEQEAKYGQAPNGLPAVSSFVSASSMAPYPTPAQVSPYMTYSAAPSGYVAGHGWQHAGGTPLSPHNCDIPAS... | Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
Subcellular locations: Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
KBP_HUMAN | Homo sapiens | MANVPWAEVCEKFQAALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDERPEAEDGPGAGDHALGLPAEVVEPEGPVAQRAVRLAVIEFHLGVNHIDTEELSAGEEHLVKCLRLLRRYRLSHDCISLCIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEVGSPPLDPTERFLPEEEKLTEQERSKRFEKVYTHNLYYLAQVYQHLEMFEKAAHYCHSTLKRQLEHNAYHPIEWAINAATLSQFYINKLCFMEARHCLSAANVIFGQTGKISATEDTPEAEGEVPELYHQRKGEIARCWIKYCLT... | Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
Subcellular locations: Cytoplasm, Cytoskeleton
Highly expressed in heart, brain, ovary, testis, spinal cord and all specific brain regions examined. Moderate expressed at inte... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
KIF6_HUMAN | Homo sapiens | MVKQTIQIFARVKPPVRKHQQGIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFDQDANQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNIHLKNLTLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSATVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKYINLSLHYLEQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCMTTMIA... | Subcellular locations: Cytoplasm, Cytoskeleton | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ANO1_HUMAN | Homo sapiens | MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLV... | Calcium-activated chloride channel (CaCC) ( ). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to bas... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SERHL_HUMAN | Homo sapiens | MAENAAPGLISELKLAVPWGHIAAKAWGSLQGPPVLCLHGWLDNASSFDRLIPLLPQDFYYVAMDFGGHGLSSHYSPGVPYYLQTFVSEIRRVVAALKWNRFSILGHSFGGVVGGMFFCTFPEMVDKLILLDTPLFLLESDEMENLLTYKRRAIEHVLQVEASQEPSHVFSLKQLLQRQRTALTSSAGSCVRIPSGSCRPMSC | Putative serine hydrolase. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CARF_HUMAN | Homo sapiens | MAQEVSEYLSQNPRVAAWVEALRCDGETDKHWRHRRDFLLRNAGDLAPAGGAASASTDEAADAESGTRNRQLQQLISFSMAWANHVFLGCRYPQKVMDKILSMAEGIKVTDAPTYTTRDELVAKVKKRGISSSNEGVEEPSKKRVIEGKNSSAVEQDHAKTSAKTERASAQQENSSTCIGSAIKSESGNSARSSGISSQNSSTSDGDRSVSSQSSSSVSSQVTTAGSGKASEAEAPDKHGSASFVSLLKSSVNSHMTQSTDSRQQSGSPKKSALEGSSASASQSSSEIEVPLLGSSGSSEVELPLLSSKPSSETASSGLT... | Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.
Subcellular locations: Nucleus, Nucleoplasm
Ubiquitously expressed. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CLCN2_HUMAN | Homo sapiens | MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQE... | Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
ITBP1_HUMAN | Homo sapiens | MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSGQSNNNSDTCAEFRIKYVGAIEKLKLSEGKGLEGPLDLINYIDVAQQDGKLPFVPPEEEFIMGVSKYGIKVSTSDQYDVLHRHALYLIIRMVCYDDGLGAGKSLLALKTTDASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSEKP | Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the co... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
R3HD4_HUMAN | Homo sapiens | MVALENPECGPEAAEGTPGGRRLLPLPSCLPALASSQVKRLSASRRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGGLPGLEDGDLAPPASPGIFAEACNNATYVEVWNDFMNRSGEEQERVLRYLEDEGRSKARRRGPGRGEDRRREDPAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFERLLLHAVCQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQHS | Subcellular locations: Nucleus | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
SYN3_HUMAN | Homo sapiens | MNFLRRRLSDSSFMANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSLSSAMKQAPQATSGLMEPPGPSTPIVQRPRILLVIDDAHTDWSKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKVVSRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGS... | May be involved in the regulation of neurotransmitter release and synaptogenesis.
Subcellular locations: Cytoplasmic vesicle, Secretory vesicle, Synaptic vesicle membrane
Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
Neuron specific. Detected predominantly in brain. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PP1RB_PANTR | Pan troglodytes | MAEAGAGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWTSDTVDNEHMGRRSSKCCCIYEKPRAFGESSTESDEEEEEGCGHTHCVRGHRKGRRRATLGPTPTTPPQPPDPSQPPPGPMQH | Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosph... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
MAGAB_HUMAN | Homo sapiens | METQFRRGGLGCSPASIKRKKKREDSGDFGLQVSTMFSEDDFQSTERAPYGPQLQWSQDLPRVQVFREQANLEDRSPRRTQRITGGEQVLWGPITQIFPTVRPADLTRVIMPLEQRSQHCKPEEGLQAQEEDLGLVGAQALQAEEQEAAFFSSTLNVGTLEELPAAESPSPPQSPQEESFSPTAMDAIFGSLSDEGSGSQEKEGPSTSPDLIDPESFSQDILHDKIIDLVHLLLRKYRVKGLITKAEMLGSVIKNYEDYFPEIFREASVCMQLLFGIDVKEVDPTSHSYVLVTSLNLSYDGIQCNEQSMPKSGLLIIVLG... | Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
Subcellular locations: Nucleus, Cytoplasm
Expressed in tumors of several types, such as ... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
CRGC_HUMAN | Homo sapiens | MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY | Crystallins are the dominant structural components of the vertebrate eye lens. | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PP4R2_PONAB | Pongo abelii | MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVYPSSEKNNSSSLNRMNGVMFPGNSPSYTERSNINGPGTPRPLNRPKVSLSAPMTTNGLPESTDSKEANLQQNEEKSHSDSSTSESEVSSVSPLKNKHPDEDAVEAEGHEVKRLRFDKEGEVRETASQTTSSEISSAVVGETETSSSSQDKDKDSRCTRQHCTEEDEEEDEEEEEESFMTSREMIP... | Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
FLII_HUMAN | Homo sapiens | MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLE... | May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
PILRA_HUMAN | Homo sapiens | MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA | Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block sig... | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
TM145_HUMAN | Homo sapiens | MEPLRAPALRRLLPPLLLLLLSLPPRARAKYVRGNLSSKEDWVFLTRFCFLSDYGRLDFRFRYPEAKCCQNILLYFDDPSQWPAVYKAGDKDCLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSGDGLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLI... | Subcellular locations: Membrane | [
{
"content": "You’re a helpful AI assistant.\nYou are given information about a protein entry from the UniProtKB Swiss-Prot dataset for primates (including humans).\nEach entry contains the following columns:\n- protein_name\n- species\n- sequence\n\nYour task is to generate the annotation for this protein, whi... |
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