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The investigation of possibilities gained by the operations that result in instances of the data type »image« but take as a starting point instances of non-pictorial data types is performed in particular in computer graphics and information visualization. The former deals with images in the closer sense, i.e., those pictures showing spatial configurations of objects (in the colloquial meaning of 'object') in a more or less naturalistic representation like, e.g., in virtual architecture. The starting point of the picture-generating algorithms in computer graphics is usually a data type that allows us to describe the geometry in three dimensions and the lighting of the scene to be depicted together with the important optical properties of the surfaces considered. Scientists in information visualization are interested in presenting pictorially any other data type, in particular those that consist of non-visual components in a "space" of states: in order to do so, a convention of visual presentation has firstly to be determined – e.g., a code of colors or certain icons. The well-known fractal images (e.g., of the Mandelbrot set) form a borderline case of information visualization since an abstract mathematical property has been visualized.
https://en.wikipedia.org/wiki?curid=5491838
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Entering the game as the best-shooting team from the field in the country at 51.6 percent, the Hoyas went on the road to face their first ranked Big East opponent, No. 15 Pittsburgh, winners of 12 straight games on their home court, on January 14. Ronald Ramón and Keith Benjamin came off the bench to replace injured starters Levance Fields and Mike Cook and scored 18 points each for the Panthers, while Pittsburgh freshman center DeJuan Blair, 7 inches (18 cm) shorter than Roy Hibbert, matched up well against Hibbert, scoring 15 points and grabbing nine rebounds, and the Panthers outrebounded the Hoyas 37-33. Although Hibbert scored 12 points, Jonathan Wallace scored 14, and Vernon Macklin contributed 10, the Hoyas shot only 44.2 percent from the field and 3-for-20 (15 percent) from three-point range and never led during the game; they began the second half behind only 27-26, but Pittsburgh started the second half with a 15-4 run to take a 42-30 lead. Georgetown scored eight consecutive points to close to 47-44 with 9:05 left in the game, but the Panthers responded by scoring six points of their own to stretch their led back to 52-44 with 8:14 left. Pittsburgh went on to upset Georgetown, 69-60, to break the Hoyas's five-game winning streak and drop Georgetown to 13-2 for the year and 3-1 in the Big East.
https://en.wikipedia.org/wiki?curid=14518554
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The risk connected to a phosgene inhalation is based not so much on its toxicity (which is much lower in comparison to modern chemical weapons like sarin or tabun) but rather on its typical effects: the affected person may not develop any symptoms for hours until an edema appears, at which point it could be too late for medical treatment to assist. Nearly all fatalities as a result of accidental releases from the industrial handling of phosgene occurred in this fashion. On the other hand, pulmonary edemas treated in a timely manner usually heal in the mid- and longterm, without major consequences once some days or weeks after exposure have passed. Nonetheless, the detrimental health effects on pulmonary function from untreated, chronic low-level exposure to phosgene should not be ignored; although not exposed to concentrations high enough to immediately cause an edema, many synthetic chemists ("e.g." Leonidas Zervas) working with the compound were reported to experience chronic respiratory health issues and eventual respiratory failure from continuous low-level exposure.
https://en.wikipedia.org/wiki?curid=47107
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Until the end of the 19th century, weather prediction was entirely subjective and based on empirical rules, with only limited understanding of the physical mechanisms behind weather processes. In 1901 Cleveland Abbe, founder of the United States Weather Bureau, proposed that the atmosphere is governed by the same principles of thermodynamics and hydrodynamics that were studied in the previous century. In 1904, Vilhelm Bjerknes derived a two-step procedure for model-based weather forecasting. First, a "diagnostic step" is used to process data to generate initial conditions, which are then advanced in time by a "prognostic step" that solves the initial value problem. He also identified seven variables that defined the state of the atmosphere at a given point: pressure, temperature, density, humidity, and the three components of the flow velocity vector. Bjerknes pointed out that equations based on mass continuity, conservation of momentum, the first and second laws of thermodynamics, and the ideal gas law could be used to estimate the state of the atmosphere in the future through numerical methods. With the exception of the second law of thermodynamics, these equations form the basis of the primitive equations used in present-day weather models.
https://en.wikipedia.org/wiki?curid=30890995
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During the years 1666 to 1669 Newton's studies were very diverse. He bought prisms and lenses on two or three occasions, and also chemicals and a furnace, apparently for chemical experiments; but he also employed part of his time on the theory of fluxions and other branches of pure mathematics. He wrote a paper, "De Analysi per Aequationes Numero Terminorum Infinitas", which he put, probably in June 1669, into the hands of Isaac Barrow (then Lucasian Professor of Mathematics), at the same time permitting him to communicate its contents to their common friend John Collins (1624–1683), a mathematician of no mean order. Barrow did so on 31 July 1669, but kept the name of the author a secret, and merely told Collins that he was a friend staying at Cambridge, who had a powerful genius for such matters. In a subsequent letter on 20 August Barrow expressed his pleasure at hearing the favourable opinion which Collins had formed of the paper, and added, "the name of the author is Newton, a fellow of our college, and a young man, who is only in his second year since he took the degree of Master of Arts, and who, with an unparalleled genius ("examine quo est acumen"), has made very great progress in this branch of mathematics". Shortly afterward Barrow resigned his chair and was instrumental in securing Newton's election as his successor.
https://en.wikipedia.org/wiki?curid=315685
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The empirical evidence for predictive coding is most robust for perceptual processing. As early as 1999, Rao and Ballard proposed a hierarchical visual processing model in which higher-order visual cortical area sends down predictions and the feedforward connections carry the residual errors between the predictions and the actual lower-level activities. According to this model, each level in the hierarchical model network (except the lowest level, which represents the image) attempts to predict the responses at the next lower level via feedback connections, and the error signal is used to correct the estimate of the input signal at each level concurrently. Emberson et al. established the top-down modulation in infants using a cross-modal audiovisual omission paradigm, determining that even infant brains have expectation about future sensory input that is carried downstream from visual cortices and are capable of expectation-based feedback. Functional near-infrared spectroscopy (fNIRS) data showed that infant occipital cortex responded to unexpected visual omission (with no visual information input) but not to expected visual omission. These results establish that in a hierarchically organized perception system, higher-order neurons send down predictions to lower-order neurons, which in turn sends back up the prediction error signal.
https://en.wikipedia.org/wiki?curid=53953041
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The main building, designed by Hermann Eggertt and , was built between 1900 and 1904 and constructed at the same time as the Electro-Technical Institute, Machine Laboratory and the Chemical Institute. All the buildings were designed in the style of the Northern Renaissance with the elements of Art Nouveau. Several stone images that decorate the front represent in symbols the purpose of the building. The Medusa head above the main entrance protects the building against intruders and signifies energy. The images above the eastern side gate are a lighthouse and the tower of St. Mary's Church, while those over the western gate are a partially damaged likeness of a steam engine and a bow of a ship. Portraits of Prussian scientists and pioneers of the 19th-century engineering are to be found above the windows of the upper ground floor – the architect Karl Friedrich Schinkel, physicist Gotthilf H. L. Hagen, a manufacturer of steam engines Johann F. A. Borsig and a naval architect Ferdinand Schichau. The ornamental gutters are decorated with copper spouts in the shape of four male figures holding water monsters.
https://en.wikipedia.org/wiki?curid=785196
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Under strongly reducing conditions, in the absence of dissolved oxygen in water, or pore water of the ground, the electron acceptor (oxidizing agent) at the cathodic sites, where reduction occurs, can be the protons () of water itself, the protons of hydrogen sulfide (), or in acidic conditions in case of severe pyrite oxidation in a former oxic atmosphere, dissolved ferric ions (), known to be very potent oxidizers. The presence of harmful reduced species of sulfur and microbial activity feeding the sulfur cycle (sulfide oxidation possibly followed by bacterial sulfate reduction) have also to be taken into account. Strictly abiotic ("i.e." inorganic) corrosion processes are generally slower under anoxic conditions than under oxic conditions, but the presence of bacteria and biofilms can aggravate the degradation conditions and causes unexpected problems. Critical infrastructures and metallic components with very long service life may be susceptible to pitting corrosion: for example the metallic canisters and overpacks aimed to contain vitrified high-level radioactive waste (HLW) and spent nuclear fuel and to confine them in a water-tight enveloppe for several tenths of thousands years in deep geologic repositories.
https://en.wikipedia.org/wiki?curid=1895068
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He also worked on the Wasserfall rocket, a radar-guided supersonic anti-aircraft missile, in which the same center-of-pressure shift was being encountered. Along the way, he developed a conical rocket propellant tank that successfully overcame liquid fuel sloshing problems, for which he won an internal prize with a monetary award that he proudly never cashed. In August 1943, when Allied forces bombed the Peenemuende facilities, he received a commendation for saving critical wind tunnel data during the ensuing fires. The Wasserfall project continued almost to the war's end, and the rocket was successfully flown but never went into production. In 1944, he and others in the group were granted civilian status, and resumed the A9/A10 development effort. In January 1945, near the end of the war, two A9 test rockets were launched with control surface designs based on the group's solution to the center-of-pressure shift. The second of these achieved stable transition to supersonic flight.
https://en.wikipedia.org/wiki?curid=22824006
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There were plenty of descriptions in Chinese literature of the time on the operations and aspects of seaports, maritime merchant shipping, overseas trade, and the sailing ships themselves. In 1117, the author Zhu Yu wrote not only of the magnetic compass for navigation, but also a hundred-foot line with a hook that was cast over the deck of the ship, used to collect mud samples at the bottom of the sea in order for the crew to determine their whereabouts by the smell and appearance of the mud. In addition, Zhu Yu wrote of watertight bulkhead compartments in the hulls of ships to prevent sinking if damaged, the for-and-aft lug, taut mat sails, and the practice of beating-to-windward. Confirming Zhu Yu's writing on Song dynasty ships with bulkhead hull compartments, in 1973 a long, wide Song trade ship from c. 1277 was dredged from the water near the southern coast of China that contained 12 bulkhead compartment rooms in its hull. Maritime culture during the Song period was enhanced by these new technologies, along with the allowance of greater river and canal traffic. All around there was a bustling display of government run grain-tax transport ships, tribute vessels and barges, private shipping vessels, a multitude of busy fishers in small fishing boats, along with the rich enjoying the comforts of their luxurious private yachts.
https://en.wikipedia.org/wiki?curid=10444102
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Black cottonwood grows on alluvial sites, riparian habitats, and moist woods on mountain slopes, from sea level to elevations of . It often forms extensive stands on bottomlands of major streams and rivers at low elevations along the Pacific Coast, west of the Cascade Range. In eastern Washington and other dry areas, it is restricted to protected valleys and canyon bottoms, along streambanks, and edges of ponds and meadows. It grows on a variety of soils from moist silts, gravels, and sands to rich humus, loams, and occasionally clays. Black cottonwood is a pioneer species that grows best in full sunlight and commonly establishes on recently disturbed alluvium. Seeds are numerous and widely dispersed because of their cottony tufts, enabling the species to colonize even burn sites, if conditions for establishment are met. Seral communities dominated or codominated by cottonwood are maintained by periodic flooding or other types of soil disturbance. Black cottonwood has low drought tolerance; it is flood-tolerant but cannot tolerate brackish water or stagnant pools.
https://en.wikipedia.org/wiki?curid=7189344
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The phosphinyl radicals synthesised by Lappert and co-workers were found to be stable at room temperature for periods of over 15 days with no effect from short-term heating at 360 K. This stability was assigned to the steric bulk of the subsituents and the abscence of beta-hydrogen atoms. A structural study of this species conducted using X-ray crystallography, gas-phase electron diffraction, and ab initio molecular orbital calculations found that the source of this stability was not the bulkiness of the CH(SiMe) ligands but the release of strain energy during homolytic cleavage at the P-P bond of the dimer that favoured the existence of the radical. The dimer shows a "syn,anti" conformation, which allows for better packing but has excessive crowding at the trimethylsilyl groups, while the radical monomer displays "syn,syn" conformation. Theoretical calculations showed that the process of cleaving the P-P bond (endothermic), relaxation to release steric strain, and rotation about the P-C bond to yield "syn,syn" conformation on the monomer radical (exothermic by 67.5 kJ for each unit) is an overall exothermic process. The stability of this species can therefore be attributed to the energy release of strain energy by the reorganisation of the ligands as the dimer converts to the radical monomer. This effect have been observed in other systems containing the CH(SiMe) ligand and was dubbed the "Jack-in-the-box" model. Other ligand with similar flexibility, and ability to undergo conformational changes were identified as PnR (Pn - P, As, Sb) and ERR' (E = Si, Ge, Sn; R' = bulky ligand).
https://en.wikipedia.org/wiki?curid=72418328
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Among the most influential ideas of the 19th century were those of Charles Darwin (alongside the independent researches of Alfred Russel Wallace), who in 1859 published the book "On the Origin of Species", which introduced the idea of evolution by natural selection. Another important landmark in medicine and biology were the successful efforts to prove the germ theory of disease. Following this, Louis Pasteur made the first vaccine against rabies, and also made many discoveries in the field of chemistry, including the asymmetry of crystals. In chemistry, Dmitri Mendeleev, following the atomic theory of John Dalton, created the first periodic table of elements. In physics, the experiments, theories and discoveries of Michael Faraday, Andre-Marie Ampere, James Clerk Maxwell, and their contemporaries led to the creation of electromagnetism as a new branch of science. Thermodynamics led to an understanding of heat and the notion of energy was defined.
https://en.wikipedia.org/wiki?curid=56661172
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All three main features listed above, namely the presence of an amniotic buffer, water-impermeable cutes and a robust respiratory system, are very important for amniotes to live on land as true terrestrial animals – the ability to reproduce in locations away from water bodies, better homeostasis in drier environments, and more efficient air respiration to power terrestrial locomotions, although they might still require regular access to drinking water for rehydration like the semiaquatic amphibians do. Because the amnion and the fluid it secretes shields the embryo from environmental fluctuations, amniotes can reproduce on dry land by either laying shelled eggs (reptiles, birds and monotremes) or nurturing fertilized eggs within the mother (marsupial and placental mammals), unlike anamniotes (fish and amphibians) that have to spawn in or closely adjacent to aquatic environments. Additional unique features are the presence of adrenocortical and chromaffin tissues as a discrete pair of glands near their kidneys, which are more complex, the presence of an astragalus for better extremity range of motion, and the complete loss of metamorphosis (which includes an egg and aquatic larval stage), gill and skin breathing, and any lateral line system.
https://en.wikipedia.org/wiki?curid=236981
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The next confirmed DES cracker was the COPACOBANA machine built in 2006 by teams of the Universities of Bochum and Kiel, both in Germany. Unlike the EFF machine, COPACOBANA consists of commercially available, reconfigurable integrated circuits. 120 of these field-programmable gate arrays (FPGAs) of type XILINX Spartan-3 1000 run in parallel. They are grouped in 20 DIMM modules, each containing 6 FPGAs. The use of reconfigurable hardware makes the machine applicable to other code breaking tasks as well. One of the more interesting aspects of COPACOBANA is its cost factor. One machine can be built for approximately $10,000. The cost decrease by roughly a factor of 25 over the EFF machine is an example of the continuous improvement of digital hardware—see Moore's law. Adjusting for inflation over 8 years yields an even higher improvement of about 30x. Since 2007, SciEngines GmbH, a spin-off company of the two project partners of COPACOBANA has enhanced and developed successors of COPACOBANA. In 2008 their COPACOBANA RIVYERA reduced the time to break DES to less than one day, using 128 Spartan-3 5000's. SciEngines RIVYERA held the record in brute-force breaking DES, having utilized 128 Spartan-3 5000 FPGAs. Their 256 Spartan-6 LX150 model has further lowered this time.
https://en.wikipedia.org/wiki?curid=7978
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Similar to all-electric vehicles (BEVs), PHEVs displace greenhouse gas emissions from the car tailpipe exhaust to the power station generators powering the electricity grid. These centralized generators may be of renewable energy (e.g. solar, wind or hydroelectric) and largely emission-free, or have an overall lower emission intensity than individual internal combustion engines. Compared to conventional hybrid electric vehicles (HEVs), PHEVs have a larger battery pack that can be charged from the power grid, which is also more efficient and can cost less than using only the on-board generator, and also often have a more powerful electric output capable of longer and more frequent EV mode driving, helping to reduce operating costs. A PHEV's battery pack is smaller than all-electric vehicles for the same vehicle weight (due to the necessity to still accommodate its combustion engine and hybrid drivetrain), but has the auxiliary option of switching back to using its gasoline/diesel engine like a conventional HEV if the battery runs low, alleviating range anxiety especially for places that lack sufficient charging infrastructure.
https://en.wikipedia.org/wiki?curid=1611987
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In the equation, formula_2 is normally the limiting conductor temperature derived from the insulation or tensile strength limitations. formula_3 is a term added to the ambient temperature formula_4 to compensate for heat generated in the jacket and insulation for higher voltages. formula_3 is called the dielectric loss temperature rise and is generally regarded as insignificant for voltages below 2000 V. Term formula_6 is a multiplier used to convert direct current resistance (formula_7) to the effective alternating current resistance (which typically includes conductor skin effects and eddy current losses). For wire sizes smaller than AWG No. 2 (), this term is generally regarded as insignificant. formula_8 is the effective thermal resistance between the conductor and the ambient conditions, which can require significant empirical or theoretical effort to estimate. With respect to the AC-sensitive terms, tabular presentation of the NM equation results in the National Electrical Code was developed assuming the standard North American power frequency of 60 hertz and sinusoidal wave forms for current and voltage.
https://en.wikipedia.org/wiki?curid=13969132
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Diagnosis of concussion requires an assessment performed by a physician or nurse practitioner to rule out severe injuries to the brain and cervical spine, mental health conditions, or other medical conditions. Diagnosis is based on physical and neurological examination findings, duration of unconsciousness (usually less than 30 minutes) and post-traumatic amnesia (PTA; usually less than 24 hours), and the Glasgow Coma Scale (people with mTBI have scores of 13 to 15). A CT scan or MRI is not required to diagnose concussion. Neuropsychological tests such as the SCAT5/child SCAT5 may be suggested measure cognitive function. Such tests may be administered hours, days, or weeks after the injury, or at different times to demonstrate any trend. Some athletes are also being tested pre-season (pre-season baseline testing) to provide a baseline for comparison in the event of an injury, though this may not reduce risk or affect return to play and baseline testing is not required or suggested for most children and adults.
https://en.wikipedia.org/wiki?curid=399231
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Many proprietary video editing systems used 68000 processors, such as the MacroSystem Casablanca, which was a black box with an easy to use graphic interface (1997). It was intended for the amateur and hobby videographer market. It is also worth noting its earlier, bigger and more professional counterpart, the "DraCo" (1995). The groundbreaking Quantel Paintbox series of early based 24-bit paint and effects system was originally released in 1981 and during its lifetime it used nearly the entire range of 68000 family processors, with the sole exception of the 68060, which was never implemented in its design. Another contender in the video arena, the Abekas 8150 DVE system, used the 680EC30, and the Trinity Play, later renamed Globecaster, uses several 68030s. The Bosch FGS-4000/4500 Video Graphics System manufactured by Robert Bosch Corporation, later BTS (1983), used a 68000 as its main processor; it drove several others to perform 3D animation in a computer that could easily apply Gouraud and Phong shading. It ran a modified Motorola VERSAdos operating system.
https://en.wikipedia.org/wiki?curid=64826
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McLaren first contested the United States Auto Club's (USAC) Indianapolis 500 race in 1970, encouraged by their tyre supplier Goodyear, which wanted to break competitor Firestone's stranglehold on the event. With the M15 car, Bruce, Chris Amon, and Denny Hulme entered, but after Amon withdrew and Hulme was severely burned on the hands in an incident in practice, Peter Revson and Carl Williams took their places in the race to retire and finish seventh, respectively. The team also contested some of the more prestigious races in the USAC championship that year, as they would do in subsequent years. For 1971 they had a new car, the M16, which driver Mark Donohue said: "...obsoleted every other car on track..." At that year's Indianapolis 500, Revson qualified on pole and finished second, whilst in 1972, Donohue won in privateer Team Penske's M16B. The 1973 event had Johnny Rutherford join the team; he qualified on pole, but finished ninth, Revson crashed out. McLaren won their first Indianapolis 500 in 1974 with Rutherford. The McLaren and Rutherford combination was second in 1975 and won again in 1976. Developments of the M16 had been used throughout this period until the new M24 car was introduced in 1977. The team did not reproduce their recent success at Indianapolis in 1977, 1978, or 1979, and although they continued to win other USAC races, by the end of 1979, they decided to end their involvement.
https://en.wikipedia.org/wiki?curid=20994
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Personas are fictitious characters created to represent a site or product's different user types and their associated demographics and technographics. Alan Cooper introduced the concept of using personas as a part of interactive design in 1998 in his book "The Inmates Are Running the Asylum", but had used this concept since as early as 1975. Personas are a usability evaluation method that can be used at various design stages. The most typical time to create personas is at the beginning of designing so that designers have a tangible idea of who the users of their product will be. Personas are the archetypes that represent actual groups of users and their needs, which can be a general description of person, context, or usage scenario. This technique turns marketing data on target user population into a few physical concepts of users to create empathy among the design team, with the final aim of tailoring a product more closely to how the personas will use it. To gather the marketing data that personas require, several tools can be used, including online surveys, web analytics, customer feedback forms, and usability tests, and interviews with customer-service representatives.
https://en.wikipedia.org/wiki?curid=288276
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In 2013, researchers have disclosed an approach with small molecules from plants. In general, it is essential to provide high-quality proof-of-concept validations early in the drug discovery process. Here technologies that enable the identification of potent, selective, and bioavailable chemical probes are of crucial interest, even if the resulting compounds require further optimization for development into a pharmaceutical product. Nuclear receptor RORα, a protein that has been targeted for more than a decade to identify potent and bioavailable agonists, was used as an example of a very challenging drug target. Hits are confirmed at the screening step due to the bell-shaped curve. This method is very similar to the quantitative HTS method (screening and hit confirmation at the same time), except that using this approach greatly decreases the data point number and can screen easily more than 100.000 biological relevant compounds.
https://en.wikipedia.org/wiki?curid=882729
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An example of mathematics' explanatory indispensability presented by Baker is the periodic cicada case. Periodical cicadas are a type of insect that have life cycles of 13 or 17 years. It is hypothesized that this acts as an evolutionary advantage because 13 and 17 are prime numbers and so have no non-trivial factors. This means that it is less likely that predators can synchronize with the cicadas' life cycles. Baker argues that this is an explanation in which mathematics, specifically number theory, is playing a key role in explaining an empirical phenomenon. Other important examples are the explanations of the hexagonal structure of bee's honeycomb, the existence of antipodes on the Earth's surface that have identical temperature and pressure, the connection between Minkowski space and Lorentz contraction, and the impossibility of crossing all Seven Bridges of Königsberg only once in a walk across the city. The main response to this form of the argument, adopted by philosophers such as Melia, Chris Daly, Simon Langford, and Juha Saatsi, is to deny that there are genuinely mathematical explanations of empirical phenomena, instead framing the role of mathematics as representational or indexical.
https://en.wikipedia.org/wiki?curid=58885745
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The Calgary Olympic Development Association (CODA) Board of Directors had originally 25 members. It was chaired by Frank King, followed by former Mayors Ralph Klein and Ross Alger, and other prominent Calgarians. The executive committee president was Robert Niven. The Olympic Organizing Committee (OOC) was formed by utilizing many of the original board of directors members. It was initially started with 11 members and was grown to 25 members by October 1983. It grew further to 29 members by 1985, when former Alberta premier, Peter Lougheed, was added to the list. An Olympic biographer, Kevin Wamsley, noted that the CEO Frank King, President Bill Pratt, Ralph Klein, and former COA President Roger Jackson had collectively the most influence on all aspects of these Winter Olympics. This organizing committee took a hierarchical form for planning these Olympics, which caused consternation from some staff, volunteers, and people in executive roles. The original staff, who were at odds with the current management structure, were either fired or willingly resigned. Also, there were claims that some of the volunteers were verbally abused. As a result, David Leighton resigned as OOC President in 1982, after only five months on the job. Therefore, Bill Pratt, a former general manager of the Calgary Stampede, became the new OCOG's president shortly afterwards. The City of Calgary and the Canadian Olympic Association (COA) delegated officially all Olympic responsibilities, including staging the Winter Olympics under the Olympic Charter, to the newly formed OCO'88 in February and September 1983 respectively.
https://en.wikipedia.org/wiki?curid=187504
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Lipkin was born in Chicago, Illinois, where he attended the University of Chicago Laboratory School and was president of the student board in 1969. He relocated to New York and earned his BA from Sarah Lawrence College in 1974. At Sarah Lawrence, he "felt that if I went straight into cultural anthropology after college I’d be a parasite. I’d go someplace, take information about myths and ritual, and have nothing to offer. So I decided to become a medical anthropologist and try to bring back traditional medicines. Suddenly I found myself in medical school." Returning to his hometown Chicago, Lipkin earned his MD from Rush Medical College, in 1978. He then became a clinical clerk at the UCL Institute of Neurology in Queen Square, London, on a fellowship, and an intern in Medicine at University of Pittsburgh (1978–1979). He completed a residency in Medicine at University of Washington (1979–1981), and completed a residency in Neurology at University of California, San Francisco (1981–1984). He conducted postdoctoral research in microbiology and neuroscience at The Scripps Research Institute, from 1984 to 1990, under the mentorship of Michael Oldstone and Floyd Bloom. In his six years at Scripps, Lipkin became a senior research associate upon completing his postdoctoral work, and was president of the Scripps' Society of Fellows in 1987.
https://en.wikipedia.org/wiki?curid=20485252
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In separate incidents during the storm and flooding caused by Hurricane Sandy on the night of October 29, 2012, one Toyota Prius Plug-in Hybrid and 16 Fisker Karmas caught fire while being parked at Port Newark-Elizabeth Marine Terminal. The vehicles were partially submerged by flash floods caused by the hurricane. In the case of the Toyota's incident, a Prius PHV burned and two other Priuses, a conventional hybrid and a plug-in, just smoldered. A Toyota spokeswoman said the fire "likely started because saltwater got into the electrical system." She also clarified that the incident affected only three cars out of the 4,000 Toyotas that were at the terminal during the storm, including more than 2,128 plug-in or hybrid models. Fisker Automotive spokesman said that the Karmas were not charging at the time of the fire and there were no injuries. After an investigation by Fisker engineers, witnessed by NHTSA representatives, the company said that the origin of the fire was "residual salt damage inside a Vehicle Control Unit submerged in seawater for several hours. Corrosion from the salt caused a short circuit in the unit, which led to a fire when the Karma's 12-Volt battery fed power into the circuit." The company explained that Sandy's heavy winds spread that fire to other Karmas parked nearby, and also ruled out the vehicles' lithium-ion battery packs as a cause of, or a contributing factor to, the fire.
https://en.wikipedia.org/wiki?curid=38267353
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The brothers wind tunnel tested about 200 wing configurations, varying the aspect ratios, curves, cambers, dihedral, and anhedral in monoplane and multiwing combinations. Each airfoil was made from sheet metal, with welded leading edges. Wilbur described using a "wind straightener...a number of narrow vertical surfaces," so as to obtain "a current very nearly constant in direction. The instrument itself was mounted in a long square tube or trough having a glass cover..." Measuring long and square, the wind was provided by a fan, connected by gears to a small internal combustion engine, all designed and built by the brothers. The resulting new glider, according to Wilbur, was "... x spreading an area of altogether. The curvature is about 1 in 25. The indications are that it will glide on an angle of about 7° to 7½° instead of 9½° to 10° as last year." Significantly, the peak of the camber was now about a third of the chord from the leading edge. The forward elevator was now smaller at and in the shape of a small wing. The glider included a hip cradle to control the wing warping, and two, fixed, vertical rudders, each measuring about by .
https://en.wikipedia.org/wiki?curid=5033561
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Gradually over time the rivers depositing the Dakota Formation sediments were submerged by the northward expansion of the Western Interior Seaway. This body of water deposited shale and chalk. Plesiosaurs lived in this sea and left behind fossils in several regions of Iowa. Northwestern Iowa's quartzite rocks may have attracted long-necked elasmosaurs as a source of gastroliths. Outside of Iowa the same deposits have preserved animals like mosasaurs and pterosaurs. During the mid-Campanian, about 75 million years ago, an asteroid roughly 1.5 miles in diameter struck the earth from the southeast near the east coast of the Western Interior Seaway. The impact site is located near the modern site of a town called Manson on the western half of the state. This event would have had a catastrophic impact on life on both land and sea for hundreds of miles around the crater, which had a diameter of roughly 22 miles. It scattered rock debris all the way to South Dakota and triggered huge tsunamis. However, despite the devastation South Dakotan fossils revealed that life recovered from the Iowan impact until the Cretaceous-Paleogene extinction event, itself likely caused by an extraterrestrial impact down in the Yucatan Peninsula of Mexico.
https://en.wikipedia.org/wiki?curid=37799107
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To examine the existing instances of data sanitization policies and determine the impacts of not developing, utilizing, or following these policy guidelines and recommendation, research data was not only coalesced from the government contracting sector but also other critical industries such as Defense, Energy, and Transportation.  These were selected as they typically also fall under government regulations, and therefore NIST (National Institute of Standards and Technology) guidelines and policies would also apply in the United States.  Primary Data is from the study performed by an independent research company Coleman Parkes Research in August 2019.  This research project targeted many different senior cyber executives and policy makers while surveying over 1,800 senior stakeholders. The data from Coleman Parkes shows that 96% of organizations have a data sanitization policy in place; however, in the United States, only 62% of respondents felt that the policy is communicated well across the business.  Additionally, it reveals that remote and contract workers were the least likely to comply with data sanitization policies.  This trend has become a more pressing issue as many government contractors and private companies have been working remotely due to the Covid-19 pandemic. The likelihood of this continuing after the return to normal working conditions is likely.
https://en.wikipedia.org/wiki?curid=67273665
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The tallest structure on campus at eight stories, the Mary and John Gray Library serves as a landmark for the university. Named after Mary and John Gray, considered to be the “first couple” of the university, the red brick structure took two and a half years to complete. The library holds extensive physical and digital collections, including 395,003 physical books, 99,548 e-books, and 142 digital databases, and provides access to current journal content from 48,851 journals. The library provides its users with a variety of digital tools, such as the online catalog and EBSCO EDS, an integrated search discovery system that allows single searches across multiple databases. Faculty and students can gain access to materials not held by our library through a robust interlibrary loan service and document delivery, in which we purchase journal articles on demand at no cost to the user. A service-oriented staff provides face-to-face, phone, and chat research assistance, as well as extensive subject guides and self-paced online tutorials to assist all Lamar users in using library resources to best advantage.
https://en.wikipedia.org/wiki?curid=624221
906,948
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In December 2018, NBME President Peter Katsufrakis and FSMB President Humayun Chaudhry wrote in opposition of USMLE Step 1 changes in "from Improving Residency Selection Requires Close Study and Better Understanding of Stakeholder Needs": "If students reduce time and effort devoted to preparing for Step 1, they may indeed devote attention to other activities that will prepare them to be good physicians. This would arguably be an ideal outcome of such a change. However, if students were to devote more time to activities that make them less prepared to provide quality care, such as binge-watching the most recent Netflix series or compulsively updating their Instagram account, this could negatively impact residency performance and ultimately patient safety. We know that assessment drives learning, so another concern resulting from a shift to pass/fail scoring may be a less knowledgeable physician population." This was met with significant backlash from students and the medical education community as this was felt to be a "tone-deaf assumption that medical trainees with more time may instead redirect their effort toward Netflix and Instagram."
https://en.wikipedia.org/wiki?curid=2555114
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The Kurgan hypothesis describes the initial spread of Proto-Indo-European during the 5th and 4th millennia BC. As used by Gimbutas, the term "kurganized" implied that the culture could have been spread by no more than small bands who imposed themselves on local people as an elite. This idea of PIE and its daughter languages diffusing east and west without mass movement proved popular with archaeologists in the 1970s (the "pots-not-people" paradigm). The question of further Indo-Europeanization of Central and Western Europe, Central Asia and Northern India during the Bronze Age is beyond the scope of the Kurgan hypothesis, and far more uncertain than the events of the Copper Age, and subject to some controversy. The rapidly developing fields of archaeogenetics and genetic genealogy since the late 1990s have not only confirmed a migratory pattern out of the Pontic Steppe at the relevant time but also suggest the possibility that the population movement involved was more substantial than earlier anticipated and invasive.
https://en.wikipedia.org/wiki?curid=1070151
296,523
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Sutherland was a well-built man of slightly under medium height, very quiet in manner. He could have been a good musician or a painter if he had been able to give the time. One of the earlier papers to bring Sutherland into notice was on the viscosity of gases which appeared in the "Philosophical Magazine" in December 1893. Other important papers dealt with the constitution of water, the viscosity of water, molecular attractions and ionization, ionic velocities and atomic sizes. The ordinary reader may refer to a discussion of his scientific work in chapter VI of Osborne's biography of Sutherland, but the full value of it could only be computed by a physicist willing to collate his papers with the state of knowledge at the time each was written. It was well known and valued in England, Germany and America. Professor T. R. Lyle said at the time of Sutherland's death that he was "the greatest authority living in molecular physics". Modest and selfless, Sutherland was content to add to the sum of human knowledge and to hope that another person would carry the work further. Sutherland never married.
https://en.wikipedia.org/wiki?curid=2422389
1,851,576
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The I-S2077 subclade of haplogroup I-Z63 was sampled on an elite warrior buried in Bodzia (Poland) in a rich burial from ca. 1010-1020 AD. All artefacts there indicate a strong relation to the Kievian Rus ruling elite, so this man who probably succumbed to combat wounds, was in a close relationship with the Kievian Prince, Sviatopolk the Accursed (son of Vladimir the Great), married to a daughter of the Polish king Boleslaw the Great (Burisleifr from the Scandinavian sagas). The cemetery in Bodzia is exceptional in terms of Scandinavian and Kievian Rus links. The Bodzia man (sample VK157, or burial E864/I) was not a simple warrior from the princely retinue, but he belonged to the princely family himself. His burial is the richest one in the whole cemetery, moreover, Strontium analysis of his teeth enamel shows he was not local. It is assumed that he came to Poland with the Prince of Kiev, Sviatopolk the Accursed, and met a violent death in combat. This corresponds to the events of 1018 AD when Sviatopolk himself disappeared after having retreated from Kiev to Poland. It cannot be excluded that the Bodzia man was Sviatopolk himself, as the genealogy of the Rurikids at this period is extremely sketchy and the dates of birth of many princes of this dynasty may be quite approximative. An autosomal PCA plot of sample VK157 against modern populations has revealed that VK157 matches most closely to the present populatation of Finland. Taking into account that subclade I-BY316/I-Y7626 bears a very strong association with Finland it may be postulated that I-BY316/I-Y7626 may have been at least partially spread over continental Europe by vikings attached to the Kievan Rus who were originally from Finland.
https://en.wikipedia.org/wiki?curid=58460808
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The university has drawn in external grants amounting to about PHP 325M (US$6.8M) from 2015 to 2020. Internal research grants of about PHP46M (US$960K) have also been awarded from the University Research Trust Fund within the same time period, while an additional PHP350M (US$7M) has been earmarked for laboratory facilities development anticipating the current changes in the Philippine educational system. Research efforts are supported by a print collection of over 200,000 titles and almost 10,000 non-print volumes housed in the university's library system, along with subscriptions to 17 online journals. USC also publishes three respected scholarly journals, "The Philippine Scientist", the "Philippine Quarterly of Culture and Society" and Devotio: Journal of Business and Economics Studies. Additional support for researchers are available through offices or committees providing ethics review, intellectual property and innovation and technology support, and animal care and use. Twenty patents have been filed by the university with the Intellectual Property Office of the Philippines (IPOPHL) from 2012 to 2018, and one start-up company, Green Enviro Management Systems (GEMS), Inc., has been established.
https://en.wikipedia.org/wiki?curid=1367948
708,706
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The gray wolf's expressive behavior is more complex than that of the coyote and golden jackal, as necessitated by its group living and hunting habits. While less gregarious canids generally possess simple repertoires of visual signals, wolves have more varied signals that subtly inter grade in intensity. When neutral, the legs are not stiffened, the tail hangs down loosely, the face is smooth, the lips untensed, and the ears point in no particular direction. Postural communication in wolves consists of a variety of facial expressions, tail positions and piloerection. Aggressive, or self-assertive wolves are characterized by their slow and deliberate movements, high body posture and raised hackles, while submissive ones carry their bodies low, sleeken their fur and lower their ears and tail. When a breeding male encounters a subordinate family member, it may stare at it, standing erect and still with the tail horizontal to its spine. Two forms of submissive behavior are recognized: passive and active. Passive submission usually occurs as a reaction to the approach of a dominant animal, and consists of the submissive wolf lying partly on its back and allowing the dominant wolf to sniff its anogenital area. Active submission occurs often as a form of greeting, and involves the submissive wolf approaching another in a low posture, and licking the other wolf's face. When wolves are together, they commonly indulge in behaviors such as nose pushing, jaw wrestling, cheek rubbing and facial licking. The mouthing of each other's muzzles is a friendly gesture, while clamping on the muzzle with bared teeth is a dominance display.
https://en.wikipedia.org/wiki?curid=61366571
1,049,409
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Orcutt Ranch was the vacation and retirement estate of William Warren Orcutt, an early pioneer of oil production in California and the discoverer of one of the first prehistoric skeletons at the La Brea Tar Pits. The Rancho Sombra del Roble, Spanish for ""Ranch of the Shaded Oak"", was originally a cattle ranch and citrus orchard at the foot of the Simi Hills. Orcutt bought the property in 1917, and hired architect L.G. Knipe (who designed some of the original campus structures of Arizona State University) to design his home on the ranch. The residence, in the blend of Spanish Colonial Revival Style and Mission Revival Style architecture, was completed in approximately 1926. It features glazed tiles from Mexico and carved mahogany and walnut from the Philippines. Visitors are surprised to find that the design of the home prominently incorporates bas-relief Swastika architectural decoration. Mary Orcutt, William's wife, chose the symbol due to its connection with Native American traditions, and did so before the Nazis turned it into a symbol of anti-Semitism and genocide. President Herbert Hoover, who was a friend of the Orcutts, visited the ranch.
https://en.wikipedia.org/wiki?curid=19502075
1,541,704
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A major problem that may occur in continuous casting is "breakout" of the liquid metal: for whatever reason, the solid shell of the strand breaks and allows the still-molten metal contained within to spill out and foul the machine. In most industrial environments this event is very costly as it leads to a shutdown of the strand and typically requires an extended turnaround involving removal of the spilled material from within the strand equipment and/or replacement of damaged machinery. A breakout is usually due to the shell wall being too thin to support the liquid column above it, a condition which has several root causes often related to heat management. Improper cooling water flow to the mould or the strand cooling sprays may lead to inadequate heat removal from the solidifying metal, causing the solid shell to thicken too slowly. If the metal withdrawal rate is too fast, the shell may not have time to solidify to the required thickness even with enhanced cooling sprays. Similarly, the incoming liquid metal may be too hot and the final solidification may occur further down the strand at a later point than expected; if this point is below the straightening rolls, the shell may break from stresses applied during straightening. A breakout can also occur as a result of physical irregularities or damage to the shell occurring within the mould during the initial seconds of solidification. Excessive turbulence within the mold may cause an irregular shell pattern that grows abnormally or it may entrap slag droplets within the shell which reduces the wall strength. A common occurrence is for the shell to stick to the mould's surface and tear; modern instrumented molds and computer control systems typically detect this and slow the caster down temporarily to let the wall refreeze and heal while it is still supported in the mould. Should the tear occur near the exit of the mould or be of unexpected severity, the shell may still fail in a breakout once it emerges from the mould wall. If the incoming metal is severely overheated, it may be preferable to stop the caster than to risk a breakout. Additionally, lead contamination of the metal (caused by counterweights or lead-acid batteries in the initial steel charge) can form a thin film between the mould wall and the steel, inhibiting heat removal and shell growth and increasing the risk of breakouts.
https://en.wikipedia.org/wiki?curid=3174561
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Several protests occurred in Bristol in 2010 in response to government spending cuts in education, including the increasing of tuition fees, and the scrapping of Education Maintenance Allowance in England. On 24 November, approximately 2000 students from the university and nearby schools gathered outside of the university and marched through the streets of Bristol. This was followed by an occupation of the Students Union building by students who criticised the union for failing to represent them on these issues. (Main article: University of Bristol Union#History) On 7 December a second occupation occurred, this time in the central university building of Senate House. The students occupying the building made a list of demands, including "greater student representation in Senate meetings" and "That the Vice-Chancellor, Eric Thomas, write and send an open letter to the Government condemning cuts in the education budget and appealing to them not to implement these policies, and to publicly call for Vice-Chancellors across the country to unite against these cuts, any rise in tuition fees and the removal of Educational Maintenance Allowance and Aimhigher." The occupiers received a considerable amount of support from members of staff. The occupation ended on 17 December 2010, with students leaving voluntarily and stating: "Although the occupiers' main demand [...] was not met, the occupation has, in many ways, yielded much more meaningful outcomes than being granted particular requests by senior management."
https://en.wikipedia.org/wiki?curid=17701372
1,950,166
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The head of the Algal Biomass Organization stated in 2010 that algae fuel could reach price parity with oil in 2018 if granted production tax credits. However, in 2013, Exxon Mobil Chairman and CEO Rex Tillerson said that after committing to spend up to $600 million over 10 years on development in a joint venture with J. Craig Venter's Synthetic Genomics in 2009, Exxon pulled back after four years (and $100 million) when it realized that algae fuel is "probably further" than 25 years away from commercial viability. In 2017, Synthetic Genomics and ExxonMobil reported a breakthrough in the joint research into advanced biofuels. The breakthrough was that they managed to double lipid content (from 20% in its natural form to 40-55 percent) in a genetically engineered strain of "Nannochloropsis gaditana". On the other hand, Solazyme, Sapphire Energy, and Algenol, among others have begun commercial sale of algal biofuel in 2012 and 2013, and 2015, respectively. By 2017, most efforts had been abandoned or changed to other applications, with only a few remaining.
https://en.wikipedia.org/wiki?curid=14205946
911,835
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The 1996 WGP is, to many, one of the best K-1 WGPs in the history of K-1, not only due to the quality of competitors but because of the emotional ending. In the first match Mike Bernardo beat Peter Aerts with a right hook in the third round to avenge his controversial lost to the "Dutch Lumberjack" last year and end the chances of Aerts becoming a three-time WGP champion. In the second first round match two famous Japanese schools of Karate collided when Seido Kaikan fighter MUSASHI took on Kyokushin fighter Sam Greco. This match ended after one round when Greco broke his toe and could not continue. Ernesto Hoost took care of the young Mirko Filipović after three rounds while Andy Hug made even shorter work Duane Van Der Merwe after a vicious KO ending the fight in 40 seconds. In the semis Bernardo got the unanimous decision over MUSASHI, while Hoost faced Andy Hug in one of the best K-1 fights up to this point which went into an extra round and saw Hug win by a slim margin. In the miracle final Andy Hug, the man that was destined to become a K-1 WGP champion but was stopped prematurely two times in a row finally made it to the finals. After two rounds Hug wore down the mighty Bernardo with leg kicks which crippled Beranrdo significantly. After another brutal kick Bernardo crumpled to the ground and was given a standing eight count, the Japanese crowd were on their feet cheering on Hug. Seconds later a beautiful spinning leg sweep from Hug brought down Bernardo again and as the referee and crowd counted Bernardo out, Hug gave a triumphant cry of victory and finally became a WGP champion.
https://en.wikipedia.org/wiki?curid=6633778
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The creation and storage of antiprotons in sufficient numbers were one of the biggest challenges in the construction of the SpS. The production of antiprotons required use of existing CERN infrastructure, such as the Proton Synchrotron (PS) and the Antiproton Accumulator (AA). Antiprotons were produced by directing an intense proton beam at a momentum of 26 GeV/c from the PS onto a target for production. The emerging burst of antiprotons had a momentum of 3.5 GeV/c, and was magnetically selected and steered into the AA, and stored for many hours. The main obstacle was the large dispersion of momenta and angles of the antiprotons emerging from the target. The method of reducing the beam dimensions is called stochastic cooling, a method discovered by Simon van der Meer. Simply put it is a feedback system based on the fact that all beams are particulate and that therefore, on a microscopic level, the density within a given volume will be subject to statistical fluctuations. The aim of discovering W and Z bosons put certain demands on the luminosity of the collider, and the experiment therefore required an antiproton source capable of delivering 3·10 antiprotons each day into a few bunches within the angular and momentum acceptance of the SPS. The accumulation of the antiprotons in the AA could take several days. The upgrade of 1986—1988 allowed for a tenfold increase in the stacking rate of the AA. A second ring, called the Antiproton Collector (AC) was built around the AA.
https://en.wikipedia.org/wiki?curid=54488524
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In 1929, Edwin Hubble provided a comprehensive observational foundation for Lemaitre's theory. Hubble's experimental observations discovered that, relative to the Earth and all other observed bodies, galaxies are receding in every direction at velocities (calculated from their observed red-shifts) directly proportional to their distance from the Earth and each other. In 1929, Hubble and Milton Humason formulated the empirical Redshift Distance Law of galaxies, nowadays known as Hubble's law, which, once the Redshift is interpreted as a measure of recession speed, is consistent with the solutions of Einstein's General Relativity Equations for a homogeneous, isotropic expanding space. The isotropic nature of the expansion was direct proof that it was the space (the fabric of existence) itself that was expanding, not the bodies in space that were simply moving further outward and apart into an infinitely larger preexisting empty void. It was this interpretation that led to the concept of the expanding universe. The law states that the greater the distance between any two galaxies, the greater their relative speed of separation. In 1929, Edwin Hubble discovered that most of the universe was expanding and moving away from everything else. If everything is moving away from everything else, then it should be thought that everything was once closer together. The logical conclusion is that at some point, all matter started from a single point a few millimetres across before exploding outward. It was so hot that it consisted of only raw energy for hundreds of thousands of years before the matter could form. Whatever happened had to unleash an unfathomable force, since the universe is still expanding billions of years later. The theory he devised to explain what he found is called the Big Bang theory.
https://en.wikipedia.org/wiki?curid=2794117
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In November 2007, to celebrate the project completion and to mark the start of a fundraising initiative for The National Museum of Computing, a Cipher Challenge pitted the rebuilt Colossus against radio amateurs worldwide in being first to receive and decode three messages enciphered using the Lorenz SZ42 and transmitted from radio station DL0HNF in the "Heinz Nixdorf MuseumsForum" computer museum. The challenge was easily won by radio amateur Joachim Schüth, who had carefully prepared for the event and developed his own signal processing and code-breaking code using Ada. The Colossus team were hampered by their wish to use World War II radio equipment, delaying them by a day because of poor reception conditions. Nevertheless, the victor's 1.4 GHz laptop, running his own code, took less than a minute to find the settings for all 12 wheels. The German codebreaker said: "My laptop digested ciphertext at a speed of 1.2 million characters per second—240 times faster than Colossus. If you scale the CPU frequency by that factor, you get an equivalent clock of 5.8 MHz for Colossus. That is a remarkable speed for a computer built in 1944."
https://en.wikipedia.org/wiki?curid=6229
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Many of the species at risk are Arctic and Antarctic fauna such as polar bears and emperor penguins. In the Arctic, the waters of Hudson Bay are ice-free for three weeks longer than they were thirty years ago, affecting polar bears, which prefer to hunt on sea ice. Species that rely on cold weather conditions such as gyrfalcons, and snowy owls that prey on lemmings that use the cold winter to their advantage may be negatively affected. Marine invertebrates achieve peak growth at the temperatures they have adapted to, and cold-blooded animals found at high latitudes and altitudes generally grow faster to compensate for the short growing season. Warmer-than-ideal conditions result in higher metabolism and consequent reductions in body size despite increased foraging, which in turn elevates the risk of predation. Indeed, even a slight increase in temperature during development impairs growth efficiency and survival rate in rainbow trout.
https://en.wikipedia.org/wiki?curid=26515241
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Building materials typically considered 'green' include lumber( that has been certified to a third-party standard), rapidly renewable plant materials (like bamboo and straw), dimension stone, recycled stone, hempcrete, recycled metal "(see: copper sustainability and recyclability)", and other non-toxic, reusable, renewable, and/or recyclable products. Materials with lower embodied energy can be used in substitution to common building materials with high degrees of energy consumption and carbon/harmful emissions. For concrete a high performance self-healing version is available, however options with lower yields of pollutive waste entertain ideas of upcycling and congregate supplementing; replacing traditional concrete mixes with slag, production waste, and aggregates. Insulation also sees multiple angles for substitution. Commonly used fiberglass has competition from other eco-friendly, low energy embodying insulators with similar or higher R-values (per inch of thickness) at a competitive price. Sheep wool, cellulose, and ThermaCork perform more efficiently, however, use may be limited by transportation or installation costs.
https://en.wikipedia.org/wiki?curid=1344439
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Porous inorganic solids have found great utility as catalysts and sorption media because of their large internal surface area, i.e. the presence of voids of controllable dimensions at the atomic, molecular, and nanometer scales. With increasing environmental concerns worldwide, nanoporous materials have become more important and useful for the separation of polluting species and the recovery of useful ones. In recent years there has been great progress in applying environmentally friendly zeolites in heterogeneous reaction catalysis. The reason for their success is related to their specific features in converting molecules having kinetic diameter below 1 nm, but they become inadequate when reactants with sizes above the dimensions of the pores have to be processed. Research efforts to synthesize zeolites with larger pore diameter, high structural stability and catalytic activity have not given the expected results yet.
https://en.wikipedia.org/wiki?curid=7074727
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The endogenous cannabinoids, or endocannabinoids, are endogenous lipids that activate cannabinoid receptors. The first such lipid to be isolated was anandamide which is the arachidonoyl amide of ethanolamine. Anandamide is formed via enzymatic release from N-arachidonoyl phosphatidylethanolamine by the N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD). Anandamide activates both the CB1 receptor, found primarily in the central nervous system, and the CB2 receptor which is found primarily in lymphocytes and the periphery. It is found at very low levels (nM) in most tissues and is inactivated by the fatty acid amide hydrolase. Subsequently, another endocannabinoid was isolated, 2-arachidonoylglycerol, which is produced when phospholipase C releases diacylglycerol which is then converted to 2-AG by diacylglycerol lipase. 2-AG can also activate both cannabinoid receptors and is inactivated by monoacylglycerol lipase. It is present at approximately 100-times the concentration of anandamide in most tissues. Elevations in either of these lipids causes analgesia and anti-inflammation and tissue protection during states of ischemia, but the precise roles played by these various endocannabinoids are still not totally known and intensive research into their function, metabolism, and regulation is ongoing. One saturated lipid from this class, often called an endocannabinoid, but with no relevant affinity for the CB1 and CB 2 receptor is palmitoylethanolamide. This signaling lipid has great affinity for the GRP55 receptor and the PPAR alpha receptor. It has been identified as an anti-inflammatory compound already in 1957, and as an analgesic compound in 1975. Rita Levi-Montalcini first identified one of its biological mechanisms of action, the inhibition of activated mast cells. Palmitoylethanolamide is the only endocannabinoid available on the market for treatment, as a food supplement.
https://en.wikipedia.org/wiki?curid=5419130
1,131,052
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After World War I, three Standard E-1s were converted to drones. The Larynx was an early cruise missile in the form of a small monoplane aircraft that could be launched from a warship and flown under autopilot; the Royal Navy tested it between 1927 and 1929. The early successes of pilotless aircraft led to the development of radio controlled pilotless target-aircraft in Britain and the US in the 1930s. In 1931 the British developed the Fairey Queen radio-controlled target from the Fairey IIIF floatplane, building a small batch of three, and in 1935 followed up this experiment by producing larger numbers of another RC target, the "DH.82B Queen Bee", derived from the de Havilland Tiger Moth biplane trainer. The name of "Queen Bee" allegedly led to the use of the term "drone" for pilotless aircraft, particularly when they are radio-controlled. During this period, the U.S. Navy, continuing work that reached back to 1917, also experimented with radio-controlled aircraft. In 1936 the head of US Navy research group used the term "DRONE" to designate radio-controlled aerial targets. From 1929 Hungarian scientist Kálmán Tihanyi worked on television guidance for defense applications, building prototypes of a camera for remotely-guided aircraft in London for the British Air Ministry, and later adapting it for the Italian Navy. In 1929, Tihanyi invented the first infrared-sensitive (night-vision) electronic television-camera for anti-aircraft defense in Britain. The solutions of the technology that Tihanyi depicted in his 1929 patent became so influential that American UAV-producing companies still used many of its solutions even half a century later, until the mid-1980s.
https://en.wikipedia.org/wiki?curid=3524423
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Ice sheets are the greatest potential source of global freshwater, holding approximately 77% of the global total. This corresponds to 80 m of world sea-level equivalent, with Antarctica accounting for 90% of this. Greenland accounts for most of the remaining 10%, with other ice bodies and glaciers accounting for less than 0.5%. Because of their size in relation to annual rates of snow accumulation and melt, the residence time of water in ice sheets can extend to 100,000 or 1 million years. Consequently, any climatic perturbations produce slow responses, occurring over glacial and interglacial periods. Valley glaciers respond rapidly to climatic fluctuations with typical response times of 10–50 years. However, the response of individual glaciers may be asynchronous to the same climatic forcing because of differences in glacier length, elevation, slope, and speed of motion. Oerlemans (1994) provided evidence of coherent global glacier retreat which could be explained by a linear warming trend of 0.66 °C per 100 years.
https://en.wikipedia.org/wiki?curid=47527
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The first known game incorporating graphics that updated in real time, rather than only when the player made a move, was a simulation of a bouncing ball created by Massachusetts Institute of Technology (MIT) student Oliver Aberth for the Whirlwind I computer. He initially created the simulation in February 1951, which allowed users to adjust the frequency of the bounces with a knob, and sometime between late 1951 and 1953 made it into a game by adding a hole in the floor for players to aim for. The game was used in classes at MIT by Charles W. Adams, assistant professor of digital computers. It was followed by a pool game programmed by William Brown and Ted Lewis specifically for a demonstration of the University of Michigan-developed MIDSAC computer at the university in 1954. The game, developed over six months by the pair, featured a pool stick controlled by a joystick and a knob, and a full rack of 15 balls on a table seen in an overhead view. The computer calculated the movements of the balls as they collided and moved around the table, disappearing when they reached a pocket, and updated the graphics continuously, forty times a second, so as to show real-time motion. Like previous video games, the pool game was intended primarily to showcase the computing power of the MIDSAC computer.
https://en.wikipedia.org/wiki?curid=19992532
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The toxins found in "Galerina marginata" are known as amatoxins. Amatoxins belong to a family of bicyclic octapeptide derivatives composed of an amino acid ring bridged by a sulfur atom and characterized by differences in their side groups; these compounds are responsible for more than 90% of fatal mushroom poisonings in humans. The amatoxins inhibit the enzyme RNA polymerase II, which copies the genetic code of DNA into messenger RNA molecules. The toxin naturally accumulates in liver cells, and the ensuing disruption of metabolism accounts for the severe liver dysfunction cause by amatoxins. Amatoxins also lead to kidney failure because, as the kidneys attempt to filter out poison, it damages the convoluted tubules and reenters the blood to recirculate and cause more damage. Initial symptoms after ingestion include severe abdominal pain, vomiting, and diarrhea which may last for six to nine hours. Beyond these symptoms, toxins severely affect the liver which results in gastrointestinal bleeding, a coma, kidney failure, or even death, usually within seven days of consumption.
https://en.wikipedia.org/wiki?curid=8749153
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From November 2000 to March 2001, Gidzenko was part of the first permanent ISS resident crew, the Expedition 1. He along with cosmonaut Sergei Krikalev and NASA astronaut William Shepherd was launched into space on board the Soyuz TM-31 spacecraft which lifted off from the Baikonour cosmodrome on October 31, 2000, at 07:52:47 UTC. Gidzenko served as the Soyuz commander. After two days of solo flight, on November 2, the Soyuz spacecraft docked with the aft port the Zvezda Service Module at 09:21 UTC. Gidzenko joined the Expedition 1 crew as a flight engineer. The crew were on board the ISS for over four months. They helped with assembly tasks as new elements, including the U.S. Destiny Laboratory, were added to the orbiting outpost. In their first weeks on board, Gidzenko, Shepherd and Krikalev activated critical life support systems and unpacked Station components, clothing, laptop computers, office equipment, cables and electrical gear left behind for them by previous Shuttle crews which conducted logistic supply flights to the new complex over the past two years.
https://en.wikipedia.org/wiki?curid=604919
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Continuing the above example: instead of assigning three discrete values to revenue growth, and to the other relevant variables, the analyst would assign an appropriate probability distribution to each variable (commonly triangular or beta), and, where possible, specify the observed or supposed correlation between the variables. These distributions would then be "sampled" repeatedly – incorporating this correlation – so as to generate several thousand random but possible scenarios, with corresponding valuations, which are then used to generate the NPV histogram. The resultant statistics (average NPV and standard deviation of NPV) will be a more accurate mirror of the project's "randomness" than the variance observed under the scenario based approach. These are often used as estimates of the underlying "spot price" and volatility for the real option valuation as above; see . A more robust Monte Carlo model would include the possible occurrence of risk events (e.g., a credit crunch) that drive variations in one or more of the DCF model inputs.
https://en.wikipedia.org/wiki?curid=34742901
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Over 91% of the primary energy supply in Ethiopia is coming from biomass as of 2015 (45.8 out of 49.9 MTOE). Additionally, in the final sectors of Ethiopian society more than 90% of the energy is coming from biomass and of that 99% is consumed by direct residencies. Often coming in the form of animal product and forestry, natural resources, biomass as a renewable energy source is utilized extensively by direct residences and the final sector. Over time Ethiopia's forests have shrunk from covering 35% of the country at the turn of the twentieth century to under 15% currently. This loss can primarily be attributed to population growth. The country's developed a strategy it calls the Woody Biomass Inventory and Strategic Planning Project to attempt to combat the noticeable degradation of vegetation cover and address resource shortages for future industrial and energy needs. As of 2008, 85% of Ethiopia's population almost exclusively relied on two types of biomass fuels for cooking: woody biomass and dung. Such a reliance on biomass backed fuels has been linked to the over 72,400 indoor air pollution caused deaths that occur annually in Ethiopia. The government plans to distribute 9 million more efficient stoves by 2015 to reduce wood use while improving air quality and lowering emissions.
https://en.wikipedia.org/wiki?curid=40906426
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The series originally grew out of five chassis built by Hayashi in Japan for the Jim Russell Racing Drivers School in California, USA. Twenty-five cars were built by Marc Bahner, Bahner Engineering, Calif., for the 1984 Long Beach Grand Prix, where the cars made their US debut. The majority of these cars were purchased by owner/operators. The original five chassis remained with the Russell School. The cars have a basic welded steel tube frame chassis, with in-board front shocks operated by upper rocker arms. A 180 hp carbureted Mazda rotary engine drives through a 5 speed H-pattern (H-gate) Hewland Mk 9 transaxle. Rear suspension is by two trailing links, an upper link and a lower a-arm. In the interest of creating close racing and limiting cost, the rules state that no modification is allowed until the rules expressly permit it—at one time even replacing the mirrors on the car was prohibited. The engines cannot be modified, and they are sealed to make it easy to detect cheating. The cars all use the same tires, springs, dampers, and adjustable anti-roll bars.
https://en.wikipedia.org/wiki?curid=2025488
1,311,522
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Harvard Medical African Expedition was a success with countless specimens collected and the customs of tribes such as Suah Koko's and those of the Gbanga and beyond Liberia in the Congo recorded. Furthermore, the photography endeavors of Loring Whitman yielded many photos ranging from local wildlife to the everyday dress and activities of the tribes, to the flesh-eating and twisting diseases whose study was the primary purpose of the venture - all, and the details of which, are printed, explained, and analyzed in Dr. Strong's two-volume "The African Republic of Liberia and the Belgian Congo: Based on the Observations Made and Material Collected during the Harvard African Expedition, 1926-1927". Furthermore, Harold Coolidge brought back a large gorilla that is still on display at the Harvard Museum of Comparative Zoology, and, in 1929, he published "A revision of the genus Gorilla", which forms the basis of the modern taxonomy of the genus Gorilla. The legacy of the Medical Expedition is twofold: at the time and as noted by Dr. Strong, the Expedition's return prompted the United States to take steps to rectify the unsanitary conditions observed in Monrovia and, in addition, "there has been much publicity and interest taken in connection with the opportunities offered by Mr. Harvey S. Firestone. However, the ultimate legacy of the venture is, like the gorilla, the lasting accumulation and possession of knowledge and specimens for study across many fields.
https://en.wikipedia.org/wiki?curid=58155305
2,090,380
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In using a number of different resuscitation parameters, the critical care team can have a better idea as to which direction is progressing. The first 24 hours often require a significant amount of resources (i.e., blood products) and investment of time from personnel within the critical care team. In many circumstances, especially trauma patients, require that other specialties address a variety of injuries. Moving the patient early on, unless absolutely necessary, can be detrimental. Certain circumstances might require this, and the patients should continue to receive care from the critical care team during the entire transport period. As the literature begins to grow within the field of damage control surgery, the medical community is continuously learning how to improve the process. Certain pitfalls have also become evident, one of which is the potential to develop abdominal compartment syndrome (ACS). While it might sound counterintuitive since the fascia is left open during the placement of these temporary closure devices, they can create a similar type process that leads to ACS. If this occurs the temporary closure device should be taken down immediately.
https://en.wikipedia.org/wiki?curid=36643113
1,191,423
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The Air Corps in January 1931 "got its foot in the door" for developing a mission for which only it would have capability, while at the same time creating a need for technological advancement of its equipment. Chief of Naval Operations Admiral William V. Pratt wanted approval of his proposition that all naval aviation including land-based aircraft was by definition tied to carrier-based fleet operations. Pratt reached an agreement with new Army Chief of Staff Douglas MacArthur that the Air Corps would assume responsibility for coastal defense (traditionally a primary function of the Army but a secondary, wartime function of the Navy) beyond the range of the Army's Coast Artillery guns, ending the Navy's apparent duplication of effort in coastal air operations. The agreement, intended as a modification of the Joint Action statement on coastal defense issued in 1926, was not endorsed by the Joint Army-Navy Board and never had authority other than a personal agreement between the two heads of service. Though the Navy repudiated the statement when Pratt retired in 1934, the Air Corps clung to the mission, and provided itself with the basis for development of long-range bombers and creating new doctrine to employ them.
https://en.wikipedia.org/wiki?curid=23869026
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The Real-Time Solar Wind (RTSW) system is continuously monitoring the solar wind and producing warnings of impending major geomagnetic activity, up to one hour in advance. Warnings and alerts issued by NOAA allow those with systems sensitive to such activity to take preventative action. The RTSW system gathers solar wind and energetic particle data at high time resolution from four ACE instruments (MAG, SWEPAM, EPAM, and SIS), packs the data into a low-rate bit stream, and broadcasts the data continuously. NASA sends real-time data to NOAA each day when downloading science data. With a combination of dedicated ground stations (CRL in Japan and RAL in Great Britain), and time on existing ground tracking networks (NASA DSN and the USAF's AFSCN), the RTSW system can receive data 24 hours per day throughout the year. The raw data are immediately sent from the ground station to the Space Weather Prediction Center in Boulder, Colorado, processed, and then delivered to its Space Weather Operations Center where they are used in daily operations; the data are also delivered to the CRL Regional Warning Center at Hiraiso Station, Japan, to the USAF 55th Space Weather Squadron, and placed on the World Wide Web. The data are downloaded, processed and dispersed within 5 minutes from the time they leave ACE. The RTSW system also uses the low-energy energetic particles to warn of approaching interplanetary shocks, and to help monitor the flux of high-energy particles that can produce radiation damage in satellite systems.
https://en.wikipedia.org/wiki?curid=1009525
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For the invocation of a procedure (or function) with parameters, their type will be known (they being declared before use) but their usage in the procedure invocation may not be. Fortran for example passes all parameters by reference (i.e. by address) so there is no immediate difficulty with generating the code (as always, with actual addresses to be fixed up later), but Pascal and other languages allow parameters to be passed by different methods at the programmer's choice (by reference, or by value, or even perhaps by "name") and this is signified only in the definition of the procedure, which is unknown before the definition has been encountered. Specifically for Pascal, in the specification of parameters a prefix "Var" signifies that it must be received by reference, its absence signifies by value. In the first case the compiler must generate code that passes the address of the parameter, while in the second it must generate different code that passes a copy of the value, usually via a stack. As always, a "fixup" mechanism could be invoked to deal with this, but it would be very messy. Multi-pass compilers can of course collate all the required information as they shuttle back and forth, but single-pass compilers cannot. Code generation could be paused while the scan advances (and its results be held in internal storage) until such time as the needed entity is encountered, and this might not be regarded as resulting in a second pass through the source because the code generation stage will soon catch up, it was merely halting for a while. But this would be complex. Instead a special construction is introduced, whereby the procedure's definition of parameter usage is declared "forward" of its later full definition so that the compiler may know it before use, as it requires.
https://en.wikipedia.org/wiki?curid=2012090
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The Royal United Services Institute (RUSI), a British defence and security think tank, released a paper in July 2010 assessing four possible options for maintaining both an effective nuclear deterrent and also reducing costs in light of anticipated budget restrictions. These proposals were motivated by the fact that funding for the Trident renewal programme now had to come from the core Ministry of Defence budget. Four alternatives were considered: Trident submarines on continuous patrol; Trident submarines not on patrol continuously; attack submarines armed with nuclear cruise missiles; and land-based nuclear weapons. The paper concluded that "given the opportunity costs for conventional capabilities that current plans for Trident renewal are due to incur over the next decade...there is now a growing case for a re-examination of whether there are less expensive means of pursuing this objective. A key element of such a review is likely to be a reconsideration of the need to maintain a commitment to CASD in strategic circumstances that are now very different from those in which it was first introduced."
https://en.wikipedia.org/wiki?curid=9095461
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The North American least shrew makes its home in burrows or shallow runways under flat stones or fallen logs. Its burrows are about 2.5 cm in diameter, from 25 cm to 1.5 m long, and seldom more than 20 cm below the ground. Most shrews are aggressive towards each other, but this species is a social creature and often cooperates in digging its burrows and often sleeps with other shrews. From 2 to 31 of these shrews will live together at a time, although it is more common to find them together in the winter months to keep warm. It will line its burrows with leaves and grass in nests for the purpose of rearing offspring. The breeding season extends from early March to late November. Females produce two or more litters each season. Each litter will consist of about three to six young, each one weighing about 0.3 g, which grow quickly and will be adult size in about one month. Litters are born 21–23 days after copulation. When first born, young are deaf, blind, and hairless. At 14 days old, they will open their eyes and have fur. By day 21, they will weigh 4-5 g and weaning will begin. The North American least shrew rarely lives more than a year. Its natural predators are owls, hawks, the red fox, the raccoon, skunks, and snakes. The North American least shrew will try to defend itself with its venomous saliva.
https://en.wikipedia.org/wiki?curid=1400053
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Epithelioid sarcoma most commonly strikes young adults, yet no age group is immune. The disease has a tendency to develop local recurrences and metastasis thereafter to regional lymph nodes, lung, bone, brain, and other locations, including the scalp. Generally speaking, epithelioid sarcoma has a high rate of relapse after initial treatment and tends to recur locally (at or near the original tumor site). Epithelioid sarcoma also demonstrates lymphatic spread (in 22-48% of cases), and metastasis (in 21-63% of cases). These events, as well as advanced stage (progression) and grade (aggressiveness), are predictive of an overall worse outcome. The overall five-year survival rate for epithelioid sarcoma is anywhere from 25 to 78%. Importantly, the 10-year and 15-year survival rate drops off significantly. Associated with a more positive outcome are younger age, female vs. male sex, distal vs. proximal location, smaller tumor size, and negative margins upon tumor resection.
https://en.wikipedia.org/wiki?curid=15025638
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Most bacterial chromosomes are circular and contain a single origin of chromosomal replication ("oriC"). Bacterial "oriC" regions are surprisingly diverse in size (ranging from 250 bp to 2 kbp), sequence, and organization; nonetheless, their ability to drive replication onset typically depends on sequence-specific readout of consensus DNA elements by the bacterial initiator, a protein called DnaA. Origins in bacteria are either continuous or bipartite and contain three functional elements that control origin activity: conserved DNA repeats that are specifically recognized by DnaA (called DnaA-boxes), an AT-rich DNA unwinding element (DUE), and binding sites for proteins that help regulate replication initiation. Interactions of DnaA both with the double-stranded (ds) DnaA-box regions and with single-stranded (ss) DNA in the DUE are important for origin activation and are mediated by different domains in the initiator protein: a Helix-turn-helix (HTH) DNA binding element and an ATPase associated with various cellular activities (AAA+) domain, respectively. While the sequence, number, and arrangement of origin-associated DnaA-boxes vary throughout the bacterial kingdom, their specific positioning and spacing in a given species are critical for "oriC" function and for productive initiation complex formation.
https://en.wikipedia.org/wiki?curid=619137
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The Cornell University Library is the 11th largest academic library in the United States, ranked by number of volumes held. Organized into 20 divisions, in 2005 it held 7.5 million printed volumes in open stacks, 8.2 million microfilms and microfiches, and a total of 440,000 maps, motion pictures, DVDs, sound recordings, and computer files in its collections, in addition to extensive digital resources and the University Archives. It was the first among all U.S. colleges and universities to allow undergraduates to borrow books from its libraries. In 2006, "The Princeton Review" ranked it as the 11th best college library, and it climbed to 6th best in 2009. The library plays an active role in furthering online archiving of scientific and historical documents. arXiv, an e-print archive created at Los Alamos National Laboratory by Paul Ginsparg, is operated and primarily funded by Cornell as part of the library's services. The archive has changed the way many physicists and mathematicians communicate, making the e-print a viable and popular means of announcing new research.
https://en.wikipedia.org/wiki?curid=7954422
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Although closed channel microfluidics (discussed in the section above) offers high customizability and biological complexity for multi-culture, the operation often requires handling expertise and specialized equipment, such as pumps and valves. In addition, the use of PDMS is known to cause adverse effects to cell culture, including leaching of oligomers or absorption of small molecules, thus often doubted by biologists. Therefore, open microfluidic devices made of polystyrene (PS), a well-established cell culture material, started to emerge. The advantages of open multi-culture designs are direct pipette accessibility and easy fabrication (micro-milling, 3D printing, injection molding, or razor-printing – without the need for a subsequent bonding step or channel clearance techniques). They can also be incorporated into traditional cultureware (well plate or petri dish) while remaining the complexity for multi-culture experiments. For example, the ‘monorail device’ which patterns hydrogel walls along a rail via spontaneous capillary flow can be inserted into commercially available 24-well plates. Flexible patterning geometries are achieved by merely changing 3D printed or milled inserts. The monorail device can also be adapted to study multikingdom soluble factor signaling, which is difficult in traditional shared media co-culture due to the different media and culture requirements for microbial and mammalian cells. Another open multi-culture device fabricated by razor-printing is capable of integrating numerous culture modalities, including 2D, 3D, Transwell, and spheroid culture. It also shows improved diffusion to promote soluble factor paracrine signaling.
https://en.wikipedia.org/wiki?curid=50311973
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In 2018, researchers from the U.S. Army Research Laboratory (ARL) developed a technique that would allow them to match facial imagery obtained using a thermal camera with those in databases that were captured using a conventional camera. Known as a cross-spectrum synthesis method due to how it bridges facial recognition from two different imaging modalities, this method synthesize a single image by analyzing multiple facial regions and details. It consists of a non-linear regression model that maps a specific thermal image into a corresponding visible facial image and an optimization issue that projects the latent projection back into the image space. ARL scientists have noted that the approach works by combining global information (i.e. features across the entire face) with local information (i.e. features regarding the eyes, nose, and mouth). According to performance tests conducted at ARL, the multi-region cross-spectrum synthesis model demonstrated a performance improvement of about 30% over baseline methods and about 5% over state-of-the-art methods.
https://en.wikipedia.org/wiki?curid=602401
394,598
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One of the 352d's greatest accomplishments was its huge victory over the Luftwaffe on 1 January 1945. In December 1944, the 352d received orders to deploy to Asch Airfield, a remote field approximately 3 miles south-southeast of As, Belgium. After arriving on 22 December, it began operating on the 24th. Poor weather hampered flight operations and the Battle of Bulge was raging nearby. Unknown to the Allies, the Luftwaffe was preparing a New Year's Day attack, designated Operation Bodenplatte against sixteen forward deployed Allied airfields in the area. Similar to the preparations for the Battle of Bulge, the Luftwaffe had been quietly preparing and assembling virtually every available fighter on the Western Front and had an estimated 800 fighters and fighter bombers ready to execute an attack when the Allies might be off guard following celebration of New Year's Eve. The concept was simple – a mass attack on newly established continental bases to destroy as many Allied aircraft on the ground and ease the pressure on German ground forces engaged in the battle of the Bulge. However, many of the Luftwaffe pilots were poorly trained and did not have the experience necessary to battle seasoned Allied pilots.
https://en.wikipedia.org/wiki?curid=2872588
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Production started at the beginning of 2001 with a team of only four programmers. Because "Resident Evil" was one of the first Capcom games developed for the GameCube, the development team had to study the system's performance during the first stages of development. Initially, the team considered creating the environments with computer graphic animation but then realized that this approach would require too much hardware capacity and processing to achieve realistic graphics. As a result, the graphical style of the remake features 3D models on top of pre-rendered backgrounds like early "Resident Evil" games. Despite this, the camera is more dynamic and can track the player at varying angles. The backgrounds also make use of particle effects and full motion video layers to simulate effects such as rushing water or swaying tree branches. Creating fear in players was a priority, and many of the game's backgrounds were designed to have a high contrast between dark and light so that enemies could appear unexpectedly.
https://en.wikipedia.org/wiki?curid=35415479
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One of the largest science projects in Canadian history, the Canadian Light Source Synchrotron at the University of Saskatchewan in Saskatoon, began operation in 2004. Covering an area the size of a football field and built at a cost of $175 million, it is operated by CLS Inc., a University of Saskatchewan not-for-profit corporation. It is used to investigate the nature of matter at very small scales. Similar in nature but smaller in scale the Advanced Laser Light Source (ALLS), was established in Quebec City at the facilities of the Institut national de recherche scientifique (University of Quebec) in 2004. The $20 million, CFI-funded international project uses a multi-beam femtosecond laser system operating in a wide range of frequencies to study the behaviour of molecules at extremely high speeds. The CFI has also provided funding for Canadian physicists to participate in research at the Spallation Neutron Source facility at the Oak Ridge National Laboratory in the US. The money will permit the design and construction of Vulcan, a spallation neutron beam source, and a spectrometer, as well as a guarantee of beam time access.
https://en.wikipedia.org/wiki?curid=18401364
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In addition, as under Mughal rule, land revenue collected in the Bengal Presidency helped finance the Company's wars in other parts of India. Consequently, in the period 1760–1800, Bengal's money supply was greatly diminished; furthermore, the closing of some local mints and close supervision of the rest, the fixing of exchange rates, and the standardization of coinage, paradoxically, added to the economic downturn. During the period, 1780–1860, India changed from being an exporter of processed goods for which it received payment in bullion, to being an exporter of raw materials and a buyer of manufactured goods. More specifically, in the 1750s, mostly fine cotton and silk was exported from India to markets in Europe, Asia, and Africa; by the second quarter of the 19th century, raw materials, which chiefly consisted of raw cotton, opium, and indigo, accounted for most of India's exports. Also, from the late 18th century British cotton mill industry began to lobby the government to both tax Indian imports and allow them access to markets in India. Starting in the 1830s, British textiles began to appear in—and soon to inundate—the Indian markets, with the value of the textile imports growing from £5.2 million in 1850 to £18.4 million in 1896. The American Civil War too would have a major impact on India's cotton economy: with the outbreak of the war, American cotton was no longer available to British manufacturers; consequently, demand for Indian cotton soared, and the prices soon quadrupled. This led many farmers in India to switch to cultivating cotton as a quick cash crop; however, with the end of the war in 1865, the demand plummeted again, creating another downturn in the agricultural economy.
https://en.wikipedia.org/wiki?curid=21670823
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Newborn screening (NBS) is a public health program of screening in infants shortly after birth for conditions that are treatable, but not clinically evident in the newborn period. The goal is to identify infants at risk for these conditions early enough to confirm the diagnosis and provide intervention that will alter the clinical course of the disease and prevent or ameliorate the clinical manifestations. NBS started with the discovery that the amino acid disorder phenylketonuria (PKU) could be treated by dietary adjustment, and that early intervention was required for the best outcome. Infants with PKU appear normal at birth, but are unable to metabolize the essential amino acid phenylalanine, resulting in irreversible intellectual disability. In the 1960s, Robert Guthrie developed a simple method using a bacterial inhibition assay that could detect high levels of phenylalanine in blood shortly after a baby was born. Guthrie also pioneered the collection of blood on filter paper which could be easily transported, recognizing the need for a simple system if the screening was going to be done on a large scale. Newborn screening around the world is still done using similar filter paper. NBS was first introduced as a public health program in the United States in the early 1960s, and has expanded to countries around the world.
https://en.wikipedia.org/wiki?curid=768605
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There have been efforts to determine the evolutionary relationships between the known plant species, but phylogenies (or phylogenetic trees) created solely using morphological data, cellular structures, single enzymes, or on only a few sequences (like rRNA) can be prone to error; morphological features are especially vulnerable when two species look physically similar though they are not closely related (as a result of convergent evolution for example) or homology, or when two species closely related look very different because, for example, they are able to change in response to their environment very well. These situations are very common in the plant kingdom. An alternative method for constructing evolutionary relationships is through changes in DNA sequence of many genes between the different species which is often more robust to problems of similar-appearing species. With the amount of genomic sequence produced by this project, many predicted evolutionary relationships could be better tested by sequence alignment to improve their certainty. With 383,679 nuclear gene family phylogenies and 2,306 gene age distributions with "Ks" plots used in the final analysis and shared in GigaDB alongside the capstone paper.
https://en.wikipedia.org/wiki?curid=26412304
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With Madabhushi as founding director, the team at Case Western Reserve University's Center for Computational Imaging and Personalized Diagnostics (CCIPD) is “involved in various different aspects of developing, evaluating and applying novel quantitative image analysis, computer vision, signal processing, segmentation, multi-modal co-registration tools, pattern recognition, and machine learning tools for disease diagnosis, prognosis, and theragnosis in the context of breast, prostate, head and neck, and brain tumors as well as epilepsy and carotid plaque. Our group is also exploring the utility of these methods in studying correlations of disease markers across multiple scales, modalities, and functionalities -- from gene and protein expression to spectroscopy to digital pathology and to multi-parametric MRI."
https://en.wikipedia.org/wiki?curid=54088361
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The reduction occurs when CeO, or ceria, is exposed to a inert atmosphere at around 1500 °C to 1600 °C, and hydrogen release occurs at 800 °C during hydrolysis when it is subjected to an atmosphere containing water vapor. One advantage of ceria over iron oxide lies in its higher melting point, which allows it to sustain higher temperature during reduction cycle. In addition, ceria's ionic conductivity allows oxygen atoms to diffuse through its structure several orders of magnitude faster than Fe ions can diffuse through iron oxide. Consequently, the redox reactions of ceria can occur at occur at a larger length scale, making it an ideal candidate for thermochemical reactor testing. Ceria-based thermochemical reactor has been created and tested as early as 2010, and viability of cycling was corroborated under realistic solar concentrating conditions. One disadvantage that limits ceria's application is its relatively lower oxygen storage capability.
https://en.wikipedia.org/wiki?curid=27636080
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The first application of the FPM to the solution of 3D compressible flows was presented in a pioneer work by (Löhner, Sacco, Oñate & Idelsohn, 2002). There, a reliable and general procedure for constructing local clouds of points (based on a Delaunay technique) and a well-suited scheme for solving the flow equations were developed. In the solution scheme proposed, the discrete flux derivatives are written along edges connecting the cloud's points as a central difference-like expression plus an upwind biased term that provides convective stabilization. An approximate Riemann solver of Roe and van Leer flux vector splitting were used for this purpose. The approach proposed is more accurate (also more expensive) than artificial dissipation methods and, additionally, does not require the definition of geometrical measures in the local cloud and problem dependent parameters. The time integration of the equations was performed through a multi-stage explicit scheme in the line of Runge-Kutta methods.
https://en.wikipedia.org/wiki?curid=50991882
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Despite the grave initial presentation in some of the patients, most of the patients survive the initial acute event, with a very low rate of in-hospital mortality or complications. Once a patient has recovered from the acute stage of the syndrome, they can expect a favorable outcome and the long-term prognosis is excellent for most. Even when ventricular systolic function is heavily compromised at presentation, it typically improves within the first few days and normalises within the first few months. Although infrequent, recurrence of the syndrome has been reported and seems to be associated with the nature of the trigger. While men experience TTS at much lower rates than women, they also experience much higher rates of complication, reoccurrence, and mortality; the cause of this sex difference is still unknown, but it is hypothesized that the social aspect of the doctor-patient interaction affects the way that physicians recognize and generate individual treatment plans for men compared to women. Stress cardiomyopathy is now a well-recognized cause of acute congestive heart failure, lethal abnormal heart rhythms, and rupture of the heart wall.
https://en.wikipedia.org/wiki?curid=7710140
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Egypt was also a center of alchemy research for much of the Mediterranean. Based on the medical papyri written in the 2500–1200 BCE, the ancient Egyptians believed that disease was mainly caused by the invasion of bodies by evil forces or spirits. Thus, in addition to using medicines, their healing therapies included prayer, incantation, and ritual. The Ebers Papyrus, written in around 1600 BCE, contains medical recipes for treating diseases related to the eyes, mouths, skins, internal organs, and extremities as well as abscesses, wounds, burns, ulcers, swollen glands, tumors, headaches, and even bad breath. The Edwin Smith papyrus, written at about the same time, contains a surgical manual for treating wounds, fractures, and dislocations. The Egyptians believed that the effectiveness of their medicines depended on the preparation and administration under appropriate rituals. Medical historians believe that ancient Egyptian pharmacology, for example, was largely ineffective. Both the Ebers and Edwin Smith papyri applied the following components to the treatment of disease: examination, diagnosis, treatment, and prognosis, which display strong parallels to the basic empirical method of science and, according to G.E.R. Lloyd, played a significant role in the development of this methodology.
https://en.wikipedia.org/wiki?curid=14400
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This section gives a brief introduction to the subject of "equivalence" in photography. Equivalent images are made by photographing the same angle of view, with the same depth of field and the same Angular resolution due to diffraction limitation (which requires different f-stops on different focal length lenses), the same motion blur (requires the same shutter speed), therefore the ISO setting must differ to compensate for the f-stop difference. The use of this is only to let us compare the effectiveness of the sensors given the same amount of light hitting them. In normal photography with any one camera, equivalence is not necessarily an issue: there are several lenses faster than f/2.4 for Micro Four Thirds (see the tables under Fixed Focal Length Lenses, below), and there are certainly many lenses faster than f/4.8 for full frame and no one hesitates to use them even though they can have shallower depth of field than a Nikon 1 at f/1.7, in fact that can be seen as advantageous, but it has to be taken into consideration that a further aspect of image resolution is limitation by optical aberration, which can be compensated the better the smaller the focal lengths of a lens is. Lenses designed for mirrorless camera systems such as Nikon 1 or Micro Four Thirds often use image-space telecentric lens designs, which reduce shading and therefore light loss and blurring at the microlenses of the image sensor. Furthermore, in low light conditions by using low f-numbers a too-shallow depth of field can lead to less satisfying image results, especially in videography, when the object being filmed by the camera or the camera itself is moving. For those interested in producing equivalent images, read on.
https://en.wikipedia.org/wiki?curid=18729407
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If we evaluate the molecular revolution within the context of biological history, it is easy to note that it is the culmination of a long process which began with the first observations through a microscope. The aim of these early researchers was to understand the functioning of living organisms by describing their organization at the microscopic level. From the end of the 18th century, the characterization of the chemical molecules which make up living beings gained increasingly greater attention, along with the birth of physiological chemistry in the 19th century, developed by the German chemist Justus von Liebig and following the birth of biochemistry at the beginning of the 20th, thanks to another German chemist Eduard Buchner. Between the molecules studied by chemists and the tiny structures visible under the optical microscope, such as the cellular nucleus or the chromosomes, there was an obscure zone, "the world of the ignored dimensions," as it was called by the chemical-physicist Wolfgang Ostwald. This world is populated by colloids, chemical compounds whose structure and properties were not well defined.
https://en.wikipedia.org/wiki?curid=4173711
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In 1981, Taube became a founding member of the World Cultural Council. As of 1997, Taube had over 600 publications, and had worked with over 250 students. He published a book, "Electron Transfer Reactions of Complex Ions in Solution (Current Chemical Concepts)" in 1970. His students have had faculty positions at many prestigious universities, including Cornell, Rutgers, Georgetown and Georgia Tech. Together with graduate student Carol Creutz, he is the namesake of the Creutz-Taube complex, a metal complex with the formula <nowiki>[</nowiki>Ru(NH)](CHN). His research contributions have been honored in several ways, including a symposium at the 1982 annual American Chemical Society meeting. The annual series "Progress in Inorganic Chemistry" dedicated its 30th volume to Taube, entitled "An Appreciation of Henry Taube." Luther College in Regina, Saskatchewan offers an annual scholarship to an entering science student in honor of Taube and his science teacher, Paul Liefeld. A seminar series was created in honor of his work at Stanford. Taube gave the inaugural lecture in the series.
https://en.wikipedia.org/wiki?curid=917657
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On Saturday evening January 9, 1892, Academic Hall fell victim to a disastrous fire, rumored to have been caused by the first electric light bulb west of the Mississippi River. The Athenaeum Society was to give an exhibition in the chapel of Academic Hall, and as the audience began to assemble, a small blaze appeared around the base of the central chandelier. A hole was immediately cut in the floor of the main library above, and water was turned on from the pressure system installed when the elevator was put in. The water supply was quickly exhausted without a significant effect on extinguishing the fire. The fire completely gutted the building by midnight, leaving little more than six stone Ionic columns standing. The fire even spread to the nearby president's residence, but it was extinguished without any significant damage to that structure. The collection in the main library was a total loss except those books that were checked out. The contents of the law library were partially salvaged. The wall of the museum was smashed in, and the exhibits were dragged out into the snow, including the controversial Emperor the elephant.
https://en.wikipedia.org/wiki?curid=17947948
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During World War II, various chloroalkanes were in standard use in military aircraft, although these early halons suffered from excessive toxicity. Nevertheless, after the war they slowly became more common in civil aviation as well. In the 1960s, fluoroalkanes and bromofluoroalkanes became available and were quickly recognized as being highly effective fire-fighting materials. Much early research with Halon 1301 was conducted under the auspices of the US Armed Forces, while Halon 1211 was, initially, mainly developed in the UK. By the late 1960s they were standard in many applications where water and dry-powder extinguishers posed a threat of damage to the protected property, including computer rooms, telecommunications switches, laboratories, museums and art collections. Beginning with warships, in the 1970s, bromofluoroalkanes also progressively came to be associated with rapid knockdown of severe fires in confined spaces with minimal risk to personnel.
https://en.wikipedia.org/wiki?curid=54910
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Kean starts by discussing Henry Moseley, who was famous for finding a mathematical relationship between the wavelengths of x-rays, the number of protons an element has, and the elements atomic number. He also built an electron gun that helped sort radioactive elements which by doing so also was able to disprove newly found elements. Moseley died on the field during World War I and his death caused scientists to search for the missing elements Moseley had discussed. The periodic table expanded as more elements were discovered. Following the timeline, Kean also discussed how the neutron was also discovered and how people became interested in radioactivity and began doing research. Upcoming radioactivity research led to the Manhattan Project to develop along with the hopes of building an atomic bomb. The Manhattan Project combined with the Monte Carlo method was successful and atomic bombs were able to be created. The Monte Carlos then strove for the development of computers and more nuclear weapons. This led to the creation of gamma radiation bombs. Kean closes the chapter by explaining how Manhattan Project veterans came up with bombs using cobalt capable of annihilating humanity and also explains the deal between the US and Soviet governments to lose any nuclear war.
https://en.wikipedia.org/wiki?curid=46736756
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However, the arrival of the British 105 mm L7 gun and the US M68 variant of it, fitted to the Centurion and M60 tanks, forced the team to undertake another audacious "première", with the adoption of composite armour. The recently created process was called "K combination" by Western armies: this protection consisted of an aluminium alloy layer between two high strength steel layers. As a consequence, the weight of the prototype rose eventually to 34 tonnes. But, as the engine was now a 700 hp (515 kW) 5TDF (also locally designed), its mobility remained excellent, far superior to that the T-62. The obyekt 432 was ready in September 1962 and production started in October 1963 in the Kharkiv plant. On 30 December 1966, it entered service as the T-64.
https://en.wikipedia.org/wiki?curid=196228
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The ancient Mesopotamians had no distinction between "rational science" and magic. When a person became ill, doctors prescribed magical formulas to be recited as well as medicinal treatments. The earliest medical prescriptions appear in Sumerian during the Third Dynasty of Ur ( 2112 BCE – 2004 BCE). The most extensive Babylonian medical text, however, is the "Diagnostic Handbook" written by the "ummânū", or chief scholar, Esagil-kin-apli of Borsippa, during the reign of the Babylonian king Adad-apla-iddina (1069–1046 BCE). In East Semitic cultures, the main medicinal authority was a kind of exorcist-healer known as an "āšipu". The profession was generally passed down from father to son and was held in extremely high regard. Of less frequent recourse was another kind of healer known as an "asu", who corresponds more closely to a modern physician and treated physical symptoms using primarily folk remedies composed of various herbs, animal products, and minerals, as well as potions, enemas, and ointments or poultices. These physicians, who could be either male or female, also dressed wounds, set limbs, and performed simple surgeries. The ancient Mesopotamians also practiced prophylaxis and took measures to prevent the spread of disease.
https://en.wikipedia.org/wiki?curid=14400
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The 2002 publication of a paper by Tikriti, "The south-east Arabian origin of the falaj system", provided the first counterpoint to the long-accepted narrative, that the Qanat originated in Persia and was identified as such by accounts of the campaigns of the Assyrian King, Sargon II, in 714 BCE. Tikriti cites this and also accounts by the Greek second and third century historian Polybius as being the basis for academic attribution of the technology to Persia. He notes academics such as JC Wilkinson (1977) adopting an Iranian origin for the technology under the influence of Sargon's annals and Polybius, but points out at least seven Iron Age "aflaj" (plural for "falaj", the word used to denote waterways of this type in the United Arab Emirates) recently discovered in the Al Ain area of the UAE have been reliably carbon dated back to the beginning of the first millennium BCE. Additional to finds of Iron Age "aflaj" in Al Ain, Tikrit pointed to excavations in Al Madam, Sharjah, by the French archaeological team working there, as well as by a German team working in Maysar, in Oman. Tikriti is at pains to point out that, despite long-standing efforts since the 19th century to excavate qanat systems in Iran, no evidence has been found for any such qanat there dated earlier than the 5th century BCE. He concludes that the technology originated in South East Arabia and was likely taken to Persia, likely by the Sasanian conquest of the Oman peninsular.
https://en.wikipedia.org/wiki?curid=59092881
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Edward Henry Kraus was born at Syracuse, New York, on December 1, 1875. His father was John Erhardt Kraus, of German ancestry, and his mother, Rosa Kocher Kraus, was of Swiss descent. After training in the high school of Syracuse, he entered Syracuse University, from which he was graduated as Bachelor of Science in 1896. During the following year he was a graduate student in that university and was also an assistant in chemistry and German. He received the degree of Master of Science at the end of the year. For two years, 1897–1899, he was instructor in German and mineralogy at Syracuse. During 1899–1901 he studied at the University of Munich, and at the end of the period received the degree of Doctor of Philosophy magna cum laude. His major study was mineralogy with chemistry and geology as minors. His doctoral thesis was entitled "Ueber einige Salze der seltenen Erden" He returned to Syracuse University for one year, first as instructor in mineralogy and then as associate professor of the same subject. During 1902–1904 he was head of the department of science in the Syracuse High School and in the summer sessions of Syracuse University of 1903 and 1904 he was professor of chemistry and geology. Dr. Kraus was a fellow of the Geological Society of America, member of the American Chemical Society, the American Association for the Advancement of Science, and other scientific organizations. For two years, 1903–1904, he was president of the Onondaga Academy of Science.
https://en.wikipedia.org/wiki?curid=36669811
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Escher's fame in popular culture grew when his work was featured by Martin Gardner in his April 1966 "Mathematical Games" column in "Scientific American". Escher's works have appeared on many album covers including The Scaffold's 1969 "L the P" with "Ascending and Descending"; Mott the Hoople's eponymous 1969 record with "Reptiles", Beaver & Krause's 1970 "In A Wild Sanctuary" with "Three Worlds"; and Mandrake Memorial's 1970 "Puzzle" with "House of Stairs" and (inside) "Curl Up". His works have similarly been used on many book covers, including some editions of Edwin Abbott's "Flatland", which used "Three Spheres"; E. H. Gombrich's "Meditations on a Hobby Horse" with "Horseman"; Pamela Hall's "Heads You Lose" with "Plane Filling 1"; Patrick A. Horton's "Mastering the Power of Story" with "Drawing Hands"; Erich Gamma et al.'s "Design Patterns: Elements of Reusable Object-oriented software" with "Swans"; and Arthur Markman's "Knowledge Representation" with "Reptiles". The "World of Escher" markets posters, neckties, T-shirts, and jigsaw puzzles of Escher's artworks. Both Austria and the Netherlands have issued postage stamps commemorating the artist and his works.
https://en.wikipedia.org/wiki?curid=20127
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Almost all cancer cells have shortened telomeres. This may seem counter-intuitive, as short telomeres should activate the ATR/ATM DNA damage checkpoint and thereby prevent division. Resolving the question of why cancer cells have short telomeres led to the development of a two-stage model for how cancer cells subvert telomeric regulation of the cell cycle. First, the DNA damage checkpoint must be inactivated to allow cells to continue dividing even when telomeres pass the critical length threshold. This requirement follows not only from the discussion above but also from "in vivo" evidence showing the function of this checkpoint in precancerous lesions and its dysfunction in late-stage tumors. Second, to survive after disabling the DNA damage checkpoint, precancerous cells must activate mechanisms to extend their telomeres. As a result of the continued division past the point of normal senescence, the telomeres of these cells become too short to prevent NHEJ(Non Homologous End Joining) and HR(Homologous Recombination) of chromosome ends, causing a state known as crisis. The application of these DSB (double strand breaks)repair mechanisms to chromosome ends leads to genetic instability, and while this instability can promote carcinogenesis, it induces apoptosis if experienced for too long. To survive and replicate, precancerous cells must stabilize their telomere lengths. This occurs through telomerase activation or the activation of a telomere-recombination pathway (i.e., the ALT pathway). Thus, cancer cells have short telomeres because they progress through an intermediate stage of telomere shortening—caused by division after DNA damage checkpoint inactivation—before enabling mechanisms for maintaining telomere length.
https://en.wikipedia.org/wiki?curid=62585682
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François Furet (1927–1997) was the leading figure in the rejection of the "classic" or "Marxist" interpretation. Desan (2000) stated he "seemed to emerge the victor from the bicentennial, both in the media and in historiographic debates." A disillusioned ex-Communist, he published his "La Révolution Française" in 1965–66. It marked his transition from revolutionary leftist politics to liberal center-left position, and reflected his ties to the social-science-oriented Annales School. He then moved to the right, re-examining the Revolution from the perspective of 20th century totalitarianism (as exemplified by Hitler and Stalin). His "Penser la Révolution Française" (1978; translated as "Interpreting the French Revolution" 1981) was an influential book that led many intellectuals to reevaluate Communism and the Revolution as inherently totalitarian and anti-democratic. Looking at modern French Communism he stressed the close resemblance between the 1960s and 1790s, with both favoring the inflexible and rote ideological discourse in party cells where decisions were made unanimously in a manipulated direct democracy. Furet further suggested that popularity of the Far Left to many French intellectuals was itself a result of their commitment to the ideals of the French Revolution. Working much of the year at the University of Chicago after 1979, Furet also rejected the Annales School, with its emphasis on very long-term structural factors, and emphasized intellectual history. Influenced by Alexis de Tocqueville and Augustin Cochin, Furet argues that Frenchmen must stop seeing the revolution as the key to all aspects of modern French history. His works include "Interpreting the French Revolution" (1981), a historiographical overview of what has preceded him and "A Critical Dictionary of the French Revolution" (1989).
https://en.wikipedia.org/wiki?curid=406597
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The concept of diffusion was first studied by the French sociologist Gabriel Tarde in late 19th century and by German and Austrian anthropologists and geographers such as Friedrich Ratzel and Leo Frobenius. The study of diffusion of innovations took off in the subfield of rural sociology in the midwestern United States in the 1920s and 1930s. Agriculture technology was advancing rapidly, and researchers started to examine how independent farmers were adopting hybrid seeds, equipment, and techniques. A study of the adoption of hybrid corn seed in Iowa by Ryan and Gross (1943) solidified the prior work on diffusion into a distinct paradigm that would be cited consistently in the future. Since its start in rural sociology, Diffusion of Innovations has been applied to numerous contexts, including medical sociology, communications, marketing, development studies, health promotion, organizational studies, knowledge management, conservation biology and complexity studies, with a particularly large impact on the use of medicines, medical techniques, and health communications. In organizational studies, its basic epidemiological or internal-influence form was formulated by H. Earl Pemberton, such as postage stamps and standardized school ethics codes.
https://en.wikipedia.org/wiki?curid=1123434
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During the 17th and 18th centuries astronomers used the ephemeris tables generated by Cassini to better understand the nature of the Jovian system and light. In 1675, Danish astronomer Ole Rømer found that observed eclipse times for Io were earlier than predicted when Jupiter was closest to Earth at opposition and later than predicted when Jupiter was furthest from Earth at conjunction. He determined that these discrepancies were due to light having a finite speed. Ole Rømer never published his findings, but he sent along his measurements to Dutch mathematician Christiaan Huygens. Huygens used Rømer's estimate of 22 minutes for light to traverse the diameter of the Earth's orbit to calculate that light traveled 220,000 km/s, 26% less than the modern value. Using Ole Rømer's data and a modern value for the astronomical unit, his measurement that light takes 16.44 minutes to travel the distance of the diameter of Earth's orbit was only 2% greater than the modern-day value, though this was not calculated at the time. In 1809, again making use of observations of Io, but this time with the benefit of more than a century of increasingly precise observations, the French astronomer Jean Baptiste Joseph Delambre reported the time for light to travel from the Sun to the Earth as 8 minutes and 12 seconds. Depending on the value assumed for the astronomical unit, this yields the speed of light as just a little more than per second.
https://en.wikipedia.org/wiki?curid=26237277
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The pilotis elevates the structure from the ground, allowing for automobiles to drive underneath through a sweeping enclosure—that was designed to correspond to the turning radius of a car—as it curves around the house to afford direct entrance. The placement of the columns are predominately practical, organized in a structurally efficient configuration, some arrangements are deployed to create subdivisions within rooms, promoting free design of the ground plan. The horizontal ribboned windows are supported by toothpick pilotis, surrounding all sides of the façade, and their intentional positioning directs the viewer's gaze to the horizon, limiting visibility of the top and bottom of the landscape; while also referencing an abstract form that obscures the diverse functionality and interior behind the façade. The roof terrace flows seamlessly from Madame Savoye's bedroom suite, constituting the culmination of the free plan and collapsing distinctions of interior and exterior space, while providing sweeping views of the pastoral visage. The white façade is open on all sides, with no definitive back or front, maximizing the site's hilltop location, so that distant views are visible from any side, since Le Corbusier envisioned the residence as an escape from the preoccupations of urban life in Paris.
https://en.wikipedia.org/wiki?curid=38574765
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In the early 1950s Henri Bader, then at the University of Minnesota, became interested in the possibility of using thermal drilling to obtain cores from holes thousands of metres deep. Lyle Hansen advised him that high voltage would be needed to prevent power loss, and this meant a transformer would need to be designed for the drill, and Bader hired an electrical engineer to develop the design. It lay unused until in 1958, with both Bader and Hansen working at SIPRE, Bader obtained an NSF grant to develop a thermal coring drill. Fred Pollack was hired as a consultant to work on the project, and Herb Ueda, who joined SIPRE in late 1958, joined Pollack's team. The original transformer design was used in the new drill, which included a 10 ft long core barrel, weighed 900 lbs, and was 30 ft long. It was tested from July to September 1959 in Greenland, at Camp Tuto, near Thule Air Base, but only drilled a total of 89 inches in three months. Pollack left when the team returned from Greenland, and Ueda took over as the team lead.
https://en.wikipedia.org/wiki?curid=56017314
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Over half the people who are diagnosed with prediabetes eventually develop type 2 diabetes and once diagnosed with prediabetes, people experience a range of emotions: distress and fear; denial and downplay of risks; guilt and self-criticism; and self-compassion. While prediabetes is a reversible condition, it requires diet change and exercise, which may be more difficult for people diagnosed prediabetes because facing the risk of a chronic condition is associated with negative emotions, which further hinder the self-regulation that is required in reversing a prediabetes diagnosis. Still, without taking action, 37% of individuals with prediabetes will develop diabetes in only 4 years, and lifestyle intervention may decrease the percentage of prediabetic patients in whom diabetes develops to 20%. The National Diabetes Prevention Program (DPP) has a Center of Disease Control (CDC)-recognized lifestyle change program that showed prediabetic people following the structured program can cut their risk of developing type 2 diabetes by 58% (71% for people over 60 years old). Considering the possibility to recover from the prediabetic status but also this emotional struggle upon diagnosis, it is encouraged for higher risk patients to get tested early. Having an additional screening option in the dental setting may offset some of the emotional struggle because it is more regularly visited and therefore has the potential to initiate earlier recognition and intervention.
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The discussion of autism prior to the twentieth century brought about much controversy. Without researchers being able to meet a consensus on the varying forms of condition, there was a lack of research being conducted on the disorder. Discussing the syndrome and its complexity frustrated researchers at the time. Controversies have surrounded various claims regarding the etiology of autism. In the 1950s, the refrigerator mother theory emerged as an explanation for autism despite no scientific evidence behind it. The hypothesis was based on the idea that autistic behaviors stem from the emotional "frigidity," lack of warmth, and cold, distant, rejecting demeanor of a child's mother. Parents of children with an ASD experienced blame, guilt and self-doubt, especially as the theory was embraced by the medical establishment and went largely unchallenged into the mid-1960s. The "refrigerator mother" theory has since been refuted in the scientific literature, including a 2015 systematic review which showed absolutely no association between caregiver interaction and language outcomes in ASD patients. Another controversial claim suggested that watching "extensive" amounts of television may cause autism. This hypothesis was largely based on research suggesting that the increasing rates of autism in the 1970s and 1980s were linked to the growth of cable television at the time.
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China entered the war in mid-October 1950, attacking advancing UN troops as they closed in on the Yalu River. No. 77 Squadron undertook its first sorties against Chinese ground forces on 1 November. The squadron flew its first missions supporting the Australian Army on 5 November, when it attacked Chinese troops opposing the 3rd Battalion, Royal Australian Regiment, at Pakchon. No. 77 Squadron personnel were housed in tents in freezing conditions at Pohung; two pilots died from burns after a fire in their quarters on 14 November. Two days later the Australians began moving forward with the 35th Group to Yonpo Airfield, near Hamhung. North Korea's counter-attack, supported by Chinese forces, led to the squadron being withdrawn to Pusan on 3 December 1950. The communists operated a Russian-designed swept-wing jet fighter, the Mikoyan-Gurevich MiG-15, that was far superior to all other fighters in the theatre except the new North American F-86 Sabre. Although the MiGs carried Chinese or North Korean markings, they were frequently operated by seasoned Russian air force pilots, whose deployment was unofficial, as the Soviet Union was not a combatant in the Korean War.
https://en.wikipedia.org/wiki?curid=3573298
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Power consumption has become increasingly important, not only in mobile devices such as laptops but also in server and desktop markets. Increasing data center machine density has led to problems delivering sufficient power to devices (especially for spin-up), and getting rid of the waste heat subsequently produced, as well as environmental and electrical cost concerns (see green computing). Most hard disk drives today support some form of power management which uses a number of specific power modes that save energy by reducing performance. When implemented, an HDD will change between a full power mode to one or more power saving modes as a function of drive usage. Recovery from the deepest mode, typically called Sleep where the drive is stopped or spun down, may take as long as several seconds to be fully operational thereby increasing the resulting latency. The drive manufacturers are also now producing "green drives" that include some additional features that do reduce power, but can adversely affect the latency including lower spindle speeds and parking heads off the media to reduce friction.
https://en.wikipedia.org/wiki?curid=32279697
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