doc_id
int32
18
2.25M
text
stringlengths
245
2.96k
source
stringlengths
38
44
__index_level_0__
int64
18
2.25M
1,937,352
The materials selected for the mission are placed into briefcase-like Passive Experiment Containers (PECs). The PECs are used for transporting experiments to and from ISS. During an EVA they are placed on handrails or at an exposed experiment facility of the ISS. The containers are opened fully (360°) so the two surfaces with experiments are facing in opposite directions. The experiments are photographed several times during their stay outside if possible, usually whenever an opportunity arises due to a scheduled EVA. After exposure in space, MISSE is retrieved in the same manner as it was deployed, the material samples are tested to see if they still have the unique properties needed to complete space missions. MISSEs have active and passive detectors to give a time-history reading, or a reading of what happened to the materials at certain points in time. Back on the ground, tests will be conducted to determine the effects of its exposure. These tests will determine which materials are strong enough to survive in space.
https://en.wikipedia.org/wiki?curid=15701481
1,936,244
141,771
Dwarves need to be provided with food and drink (mostly in the form of alcohol). A dwarf will get negative thoughts for drinking plain water and even for drinking the same type of alcohol, making it necessary to grow different crops for producing different drinks. Things like not having a separate bedroom can upset a dwarf. They may make friends and sometimes marry; females give birth. Dwarves can get upset by sustaining injuries, having poor clothing, losing their pets, friends or relatives; interacting with or seeing their corpses can aggravate this. A frustrated dwarf may break furniture or attack others. Continuous stress will cause them to throw tantrums and eventually go "insane", whether going berserk and attacking their comrades in a homicidal rage, becoming suicidally depressed and jumping off a cliff, or simply going "stark raving mad" and stumbling around randomly until their untimely death. Their quality of life can be improved by giving them luxurious personal bedrooms and a well-decorated dining room, medical care, and providing them with a variety of drinks and well-cooked meals. A chain reaction where a single dwarf's unhappiness causes the entire fortress's population to start throwing tantrums can begin when one dwarf throws a tantrum, attacks and kills another one with many friends, which drastically affects the happiness of many more.
https://en.wikipedia.org/wiki?curid=7239234
141,713
648,869
Regardless, after a series of internal battles, Symbolics did get off the ground in 1980/1981, selling the CADR as the LM-2, while Lisp Machines, Inc. sold it as the LMI-CADR. Symbolics did not intend to produce many LM-2s, since the 3600 family of Lisp machines was supposed to ship quickly, but the 3600s were repeatedly delayed, and Symbolics ended up producing ~100 LM-2s, each of which sold for $70,000. Both firms developed second-generation products based on the CADR: the Symbolics 3600 and the LMI-LAMBDA (of which LMI managed to sell ~200). The 3600, which shipped a year late, expanded on the CADR by widening the machine word to 36-bits, expanding the address space to 28-bits, and adding hardware to accelerate certain common functions that were implemented in microcode on the CADR. The LMI-LAMBDA, which came out a year after the 3600, in 1983, was compatible with the CADR (it could run CADR microcode), but hardware differences existed. Texas Instruments (TI) joined the fray when it licensed the LMI-LAMBDA design and produced its own variant, the TI Explorer. Some of the LMI-LAMBDAs and the TI Explorer were dual systems with both a Lisp and a Unix processor. TI also developed a 32-bit microprocessor version of its Lisp CPU for the TI Explorer. This Lisp chip also was used for the MicroExplorer – a NuBus board for the Apple Macintosh II (NuBus was initially developed at MIT for use in Lisp machines).
https://en.wikipedia.org/wiki?curid=18123
648,528
119,354
Early projects like the Whirlwind and SAGE Projects introduced the CRT as a viable display and interaction interface and introduced the light pen as an input device. Douglas T. Ross of the Whirlwind SAGE system performed a personal experiment in which he wrote a small program that captured the movement of his finger and displayed its vector (his traced name) on a display scope. One of the first interactive video games to feature recognizable, interactive graphics – "Tennis for Two" – was created for an oscilloscope by William Higinbotham to entertain visitors in 1958 at Brookhaven National Laboratory and simulated a tennis match. In 1959, Douglas T. Ross innovated again while working at MIT on transforming mathematic statements into computer generated 3D machine tool vectors by taking the opportunity to create a display scope image of a Disney cartoon character.
https://en.wikipedia.org/wiki?curid=18567210
119,305
1,140,746
Supersymmetric theory of stochastic dynamics can be interesting in different ways. For example, STS offers a promising realization of the concept of supersymmetry. In general, there are two major problems in the context of supersymmetry. The first is establishing connections between this mathematical entity and the real world. Within STS, supersymmetry is the most common symmetry in nature because it is pertinent to all continuous time dynamical systems. The second is the spontaneous breakdown of supersymmetry. This problem is particularly important for particle physics because supersymmetry of elementary particles, if exists at extremely short scale, must be broken spontaneously at large scale. This problem is nontrivial because supersymmetries are hard to break spontaneously, the very reason behind the introduction of soft or explicit supersymmetry breaking. Within STS, spontaneous breakdown of supersymmetry is indeed a nontrivial dynamical phenomenon that has been variously known across disciplines as chaos, turbulence, self-organized criticality etc.
https://en.wikipedia.org/wiki?curid=53961341
1,140,152
404,226
After the series of powerful storm systems of the 2005 Atlantic hurricane season, as well as after Hurricane Patricia, a few newspaper columnists and scientists brought up the suggestion of introducing Category 6, and they have suggested pegging Category 6 to storms with winds greater than . Fresh calls were made for consideration of the issue after Hurricane Irma in 2017, which was the subject of a number of seemingly credible false news reports as a "Category 6" storm, partly in consequence of so many local politicians using the term. Only a few storms of this intensity have been recorded. Of the 37 hurricanes currently considered to have attained Category 5 status in the Atlantic, 18 had wind speeds at or greater and only eight had wind speeds at or greater (the 1935 Labor Day hurricane, Allen, Gilbert, Mitch, Rita, Wilma, Irma, and Dorian). Of the 18 hurricanes currently considered to have attained Category 5 status in the eastern Pacific, only five had wind speeds at or greater (Patsy, John, Linda, Rick, and Patricia), and only three had wind speeds at or greater (Linda, Rick, and Patricia). Most storms which would be eligible for this category were typhoons in the western Pacific, most notably typhoons Tip and Halong in 1979 and 2019 and respectively, each with sustained winds of , and typhoons Haiyan, Meranti, Goni, and Surigae in 2013, 2016, 2020 and 2021 respectively, each with sustained winds of . Occasionally, suggestions of using even higher wind speeds as the cutoff have been made. In a newspaper article published in November 2018, NOAA research scientist Jim Kossin said that the potential for more intense hurricanes was increasing as the climate warmed, and suggested that Category 6 would begin at , with a further hypothetical Category 7 beginning at .
https://en.wikipedia.org/wiki?curid=255313
404,026
1,672,730
On 7 September 2001, Callum was promoted to lead Mazda worldwide design, where his team included Tsutomu "Tom" Matano, the designer of the Mazda MX-5. Callum was tasked with revitalising the Mazda range, which by the late 1990s was regarded as bland, and in this respect Callum has largely been viewed as successful with the creation of a consistent brand look that featured 'crisp black interiors and red-lighted instruments' and exteriors with 'edgy shapes that were emotional and almost biological – part flame, part flower, expressive of the sporting image the company sought'. He oversaw the daunting 2005 redesign of the iconic MX-5 and worked on almost every other vehicle in Mazda's passenger car range including the 2006 Mazda5. He was also responsible for leading the design of Mazda's new sporty crossovers, the 2007 CX-7 and CX-9 which were previewed by the 2005 Mazda MX-Crossport concept. He was also instrumental in the production of the Washu (Detroit 2003), Ibuki (Tokyo 2003), and Kabura (Detroit 2006) concept cars.
https://en.wikipedia.org/wiki?curid=3636781
1,671,788
1,561,409
Morris returned to Melbourne in 1968 to the University of Melbourne's Department of Surgery, becoming Reader in Surgery in 1971. In 1973, at the age of 39, he was appointed to the Nuffield Chair of Surgery at the University of Oxford. He held this post for 28 years before being elected as President of The Royal College of Surgeons of England from 2001 to 2004. On arrival in Oxford he established the transplantation program at the Oxford Transplant Centre of which he was Director. He was also the co-founder with John Bell of the Wellcome Trust Centre for Human Genetics. He served as Director of the Centre for Evidence in Transplantation (CET) at the Royal College of Surgeons and the London School of Hygiene and Tropical Medicine, where he held an Honorary Professorship and was a member of Court. He served as Chairman of the British Heart Foundation for 8 years and was President of the Medical Protection Society.
https://en.wikipedia.org/wiki?curid=30470763
1,560,523
323,522
As noted, the process of ice formation and movement is a key driver in Arctic Ocean circulation and the formation of water masses. With this dependence, the Arctic Ocean experiences variations due to seasonal changes in sea ice cover. Sea ice movement is the result of wind forcing, which is related to a number of meteorological conditions that the Arctic experiences throughout the year. For example, the Beaufort High—an extension of the Siberian High system—is a pressure system that drives the anticyclonic motion of the Beaufort Gyre. During the summer, this area of high pressure is pushed out closer to its Siberian and Canadian sides. In addition, there is a sea level pressure (SLP) ridge over Greenland that drives strong northerly winds through the Fram Strait, facilitating ice export. In the summer, the SLP contrast is smaller, producing weaker winds. A final example of seasonal pressure system movement is the low pressure system that exists over the Nordic and Barents Seas. It is an extension of the Icelandic Low, which creates cyclonic ocean circulation in this area. The low shifts to centre over the North Pole in the summer. These variations in the Arctic all contribute to ice drift reaching its weakest point during the summer months. There is also evidence that the drift is associated with the phase of the Arctic Oscillation and Atlantic Multidecadal Oscillation.
https://en.wikipedia.org/wiki?curid=18951556
323,350
143,244
The "baya tabla" is a bit bigger and deep kettledrum shaped, about 20 centimetres (~8 in) in diameter and 25 centimetres (~10 in) in height. It played with the non-dominant hand, is called bāyāñ (literally "left") duggī or dhāmā (correctly called "dagga"), has a much deeper bass tone, much like its distant cousin, the kettle drum. The bāyāñs can be found to be made up of many different types of materials. Brass is the most common, copper is more expensive, but generally held to be the best, while aluminum and steel are often found in inexpensive models. Sometimes wood is used, especially in old bāyāñs from the Punjab. Clay is also used, although not favored for durability; these are generally found in the North-East region of Bengal. The "baya" construction and tuning is about a fifth to an octave below that of the "daya" drum. The musician uses his hand's heel pressure to change the pitch and tone colour of each drum during a performance.
https://en.wikipedia.org/wiki?curid=21787554
143,186
1,527,308
Another important focus of Jayachandran's research revolves around deforestation in Indonesia and Uganda. In a 2008 publication, she showed that massive forest fires in Indonesia caused air pollution that had adverse impacts on pregnant women and babies in poor communities, leading to more than 15,000 fetal and infant deaths. In 2017, with a group of collaborators, she published research in "Science" showing that landowners in Uganda would preserve forests if they were paid to preserve forest cover. She found that landowners who were offered a conservation contract only cleared 4% of land as opposed to the 9% cleared in villages without a contract. This delayed 3000 metric tons of carbon dioxide at a cost of 46 cents per ton. These results were covered in the New York Times.
https://en.wikipedia.org/wiki?curid=58723747
1,526,444
1,924,376
The AIAS celebrated 15 years of Freedom By Design at FORUM 2019 in Toronto, Ontario. Executive director Nick Serfass, CAE left the AIAS after years of dedicated service and is replaced by Karma Israelsen, MA. The AIAS continues to expand oversees, seeing particular growth among students in Latin America and the Middle East. In 2020, new board positions are established for Latin America and the Middle East to represent international members in those regions. Advocacy continues to be a major focus of the organization, and president Sarah Curry (Auburn University) publishes the AIAS' promise to communities of color. The organization publishes a new document on learning and teaching culture to advocate for healthy learning environments and the board adopts a set of public policies.
https://en.wikipedia.org/wiki?curid=607666
1,923,273
2,103,936
Kodur's research has focused on the experimental behavior and analytical modeling of structural systems under extreme fire conditions, Constitutive modelling of material properties at elevated temperatures, Fire resistance design of structural systems, and Building collapse investigations. His contributions to the field of structural fire safety and high performing construction materials are seminal and numerous, and his research accomplishments have had major impacts. He has developed fundamental understanding on the behavior of materials and structural systems under extreme fire conditions. The techniques and methodologies resulting from his research is instrumental for minimizing the destructive impact of fire in the built infrastructure, which continues to cause thousands of deaths and billions of dollars of damage each year in the US and around the world. Many of these design approaches and fire resistance solutions have been incorporated in to various construction codes and design standards in the US and around the world.
https://en.wikipedia.org/wiki?curid=54449177
2,102,724
1,343,486
"M. ulcerans" likely evolved from the closely related aquatic pathogen "Mycobacterium marinum" around one million years ago. The two species are genetically very similar, and have identical 16S ribosomal RNA genes. However relative to "M. marinum", "M. ulcerans" has undergone substantial genome reduction, shedding over a thousand kilobases of genetic content including nearly 1300 genes (23% of the total "M. marinum" genes) and sustaining the inactivation of an additional 700 genes. Some of these genes were inactivated by the proliferation of two mobile genetic elements, called "IS2404" (213 copies) and "IS2606" (91 copies), neither of which are present in "M. marinum". Additionally, "M. ulcerans" has acquired a 174 kilobase plasmid, termed "pMUM001", which is involved in the production of the toxin mycolactone. Other closely related mycobacteria produce mycolactone and infect various aquatic animals; these are sometimes described as distinct species ("M. pseudoshottsii", "M. liflandii", "M. shinshuense" and sometimes "M. marinum") and sometimes as different lineages of "M. ulcerans". Regardless, all mycolactone-producing mycobacteria share a common ancestor distinct from non-mycolactone-producing "M. marinum".
https://en.wikipedia.org/wiki?curid=65008877
1,342,750
223,833
Accordingly, Diesel sought to compromise. He calculated that, were he to reduce the peak pressure to a less ambitious 90 atmospheres, he would sacrifice only 5% of the thermal efficiency. Seeking financial support, he published the "Theory and Construction of a Rational Heat Engine to Take the Place of the Steam Engine and All Presently Known Combustion Engines" (1893). Endorsed by scientific opinion, including Lord Kelvin, he won the backing of Krupp and Maschinenfabrik Augsburg. He clung to the Carnot cycle as a symbol. But years of practical work failed to achieve an isothermal combustion engine, nor could have done, since it requires such an enormous quantity of air that it cannot develop enough power to compress it. Furthermore, controlled fuel injection turned out to be no easy matter.
https://en.wikipedia.org/wiki?curid=6118
223,719
1,497,777
In a small low-dose study using 280 mg/day oral EMP for 150 days, tolerability was significantly improved, with gastrointestinal irritation occurring in only 15% of men, and there was no incidence of severe cardiovascular toxicity or deep vein thrombosis. In addition, no other side effects besides slight transient elevated liver enzymes were observed. These findings suggest that lower doses of oral EMP may be a safer option than higher doses for the treatment of prostate cancer. However, a subsequent 2004 meta-analysis of 23 studies of thromboembolic events with EMP found substantial incidence of thromboembolic events regardless of dosage and no association of EMP dose with risk of these complications.
https://en.wikipedia.org/wiki?curid=4498159
1,496,934
1,752,734
The recently founded English colony had been included in the expedition’s itinerary in response to a memorandum drawn up in September 1788 by one of Malaspina’s fellow naval officers, Francisco Muñoz y San Clemente, who warned of the dangers it posed to the Spanish possessions in the Pacific in peace time from the development of a contraband commerce and in war time as a base for British naval operations. Muñoz said: "The colonists will be able to fit out lucrative privateers so as to cut all communication between the Philippines and both Americas... These possessions will have a navy of their own, obtaining from the Southern region whatever is necessary to establish it, and when they have it ready formed they will be able to invade our nearby possessions..." In the confidential report he wrote following his visit, Malaspina echoed the warning from Muñoz, writing of the "terrible" future danger for Spain from the English colony at Port Jackson,
https://en.wikipedia.org/wiki?curid=6370301
1,751,746
1,103,855
The genus "Xanthomonas" has been subject of numerous taxonomic and phylogenetic studies and was first described as "Bacterium vesicatorium" as a pathogen of pepper and tomato in 1921. Dowson later reclassified the bacterium as "Xanthomonas campestris" and proposed the genus "Xanthomonas"."Xanthomonas" was first described as a monotypic genus and further research resulted in the division into two groups, A and B. Later work using DNA:DNA hybridization has served as a framework for the general "Xanthomonas" species classification. Other tools, including multilocus sequence analysis and amplified fragment-length polymorphism, have been used for classification within clades. While previous research has illustrated the complexity of the genus "Xanthomonas", recent research appears to have resulted in a clearer picture. More recently, genome-wide analysis of multiple "Xanthomonas" strains mostly supports the previous phylogenies. "Xanthomonas spp". are evolutionary linked to opportunistic human pathogen "Stenotrophomonas maltophilia", that was previously called "Xanthomonas maltophilia". There is a proposal to reorganize "Xanthomonas" banana and maize/corn pathotypes along the lines of the most recent phylogenetic data.
https://en.wikipedia.org/wiki?curid=10857383
1,103,293
707,111
Organic certification, as well as fair trade certification, has the potential to directly and indirectly contribute to the achievement of some of the Millennium Development Goals (MDGs), which are the eight international development goals that were established following the Millennium Summit of the United Nations in 2000, with all United Nations member states committed to help achieve the MDGs by 2015. With the growth of ethical consumerism in developed countries, imports of eco-friendly and socially certified produce from the poor in developing countries have increased, which could contribute towards the achievement of the MDGs. A study by Setboonsarng (2008) reveals that organic certification substantially contributes to MDG1 (poverty and hunger) and MDG7 (environmental sustainability) by way of premium prices and better market access, among others. This study concludes that for this market-based development scheme to broaden its poverty impacts, public sector support in harmonizing standards, building up the capacity of certifiers, developing infrastructure development, and innovating alternative certification systems will be required.
https://en.wikipedia.org/wiki?curid=412765
706,742
1,677,142
Climate change and warming of Arctic and Antarctic regions have the potential to greatly alter ecosystem functioning. Decreasing ice cover in polar regions is expected to lessen the relative proportion of sea ice algae production to measures of annual primary production. Thinning ice allows for greater production early in the season but early ice melting shortens the overall growing season of the sea ice algae. This melting also contributes to stratification of the water column that alters the availability of nutrients for algae growth by decreasing the depth of the surface mixed layer and inhibiting the upwelling of nutrients from deep waters. This is expected to cause an overall shift towards pelagic phytoplankton production. Changes in multiyear ice volume will also have an impact on ecosystem function in terms of bloom seeding source adjustment. Reduction in MYI, a temporal refugia for diatoms in particular, will likely alter sympagic community composition, resulting in bloom initialization that derives from species that overwinter in the water column or sediments instead.
https://en.wikipedia.org/wiki?curid=2065110
1,676,200
335,819
COBOL (; an acronym for "common business-oriented language") is a compiled English-like computer programming language designed for business use. It is an imperative, procedural and, since 2002, object-oriented language. COBOL is primarily used in business, finance, and administrative systems for companies and governments. COBOL is still widely used in applications deployed on mainframe computers, such as large-scale batch and transaction processing jobs. However, due to its declining popularity and the retirement of experienced COBOL programmers, programs are being migrated to new platforms, rewritten in modern languages or replaced with software packages. Most programming in COBOL is now purely to maintain existing applications; however, many large financial institutions were still developing new systems in COBOL as late as 2006.
https://en.wikipedia.org/wiki?curid=6799
335,641
863,351
Let formula_24 be the position, formula_25 be the kinetic energy, formula_13 the potential energy, both independent of time formula_27. Lagrange's equation of motion readsformula_28Here, the dot notation for the time derivative is used, formula_29. Poisson set formula_30. He argued that if formula_13 is independent of formula_32, he could writeformula_33giving formula_34He introduced an explicit formula for momenta,formula_35Thus, from the equation of motion, he gotformula_36Poisson's text influenced the work of William Rowan Hamilton and Carl Gustav Jacob Jacobi. A translation of Poisson's Treatise on Mechanics was published in London in 1842. Let formula_37 and formula_38 be functions of the canonical variables of motion formula_39 and formula_40. Then their Poisson bracket is given byformula_41Evidently, the operation anti-commutes. More precisely, formula_42. By Hamilton's equations of motion, the total time derivative of formula_43 isformula_44where formula_45 is the Hamiltonian. In terms of Poisson brackets, then, Hamilton's equations can be written as formula_46 and formula_47.
https://en.wikipedia.org/wiki?curid=44670
862,891
694,515
Phytoplasmas belong to the monotypic order Acholeplasmatales. In 1992, the Subcommittee on the Taxonomy of Mollicutes proposed the use of 'Phytoplasma' rather than 'mycoplasma-like organisms' 'for reference to the phytopathogenic mollicutes'. In 2004, the generic name Phytoplasma was adopted and is currently of Candidatus (Ca.) status (used for bacteria that cannot be cultured). Phytoplasma taxonomy is complicated because the organisms cannot be cultured; methods normally used to classify prokaryotes are thus not available. Phytoplasma taxonomic groups are based on differences in fragment sizes produced by restriction digests of 16S ribosomal RNA gene sequences (RFLPs) or by comparisons of DNA sequences from 16s/23s spacer regions. The actual number of taxonomic groups remains unclear; recent work on computer-simulated restriction digests of the 16Sr gene suggested up to 28 groups, whereas others have proposed fewer groups with more subgroups. Each group includes at least one "Ca." Phytoplasma species, characterized by distinctive biological, phytopathological, and genetic properties.
https://en.wikipedia.org/wiki?curid=1041312
694,152
1,942,253
Excellent research at the interface of digital technologies and entrepreneurship is another task of the CDTM. The conducted research focuses on new technologies that will become relevant in five to ten years. In detail, topics such as prototyping, business model innovation, and technology transfer are addressed. A particularity at the CDTM is the close link between research and teaching. An interdisciplinary structure enables the incorporation of expertise from students, doctoral students, and professors. For instance, current topics are integrated into courses, and students are involved in research projects through seminars and theses. Publicly funded research projects of the European Union are, for example, innovative educational initiatives in the food industry or the health sector. But also private research projects are carried out at the CDTM. In numerous projects, the CDTM cooperates with institutes such as the Karolinska Institute, the European Institute of Innovation & Technology (EIT) or educational institutions such as the IESE Business School, Imperial College London, Queen's University Belfast, or the University of Cambridge.
https://en.wikipedia.org/wiki?curid=39695126
1,941,142
788,645
In addition to the instrumental ensembles, WVSU features a concert choir called the State A Capella and an audition-only chamber vocal ensemble called State Singers. Depending on enrollment, vocal ensembles specifically for male and female groups may also be offered. The State Singers consists of eight to ten vocalists and also occasionally perform as the WVSU Vocal Jazz Choir. The State Singers act as ambassadors for the university and frequently perform off campus for important community and cultural events. Every spring, the State Singers go on tour. Recent tours have taken the group to Cleveland, Ohio, Virginia Beach, St. Louis, Missouri, and New York City. On April 13 and 14, 2012, the concert choir had the unique opportunity of singing the music of "Queen" with the West Virginia Symphony Orchestra. The concert choir again sang with the WVSO for the symphony's 2012 holiday concerts, and have continued since. In March 2016, the concert choir again joined the symphony, along with three other West Virginia collegiate choirs, to perform the Brahms Requiem. Dr. Dirk Johnson is the Director of Choral Activities for WVSU and has been at that position since the fall of 2009. He is also the current Chair of the WVSU Department of Music.
https://en.wikipedia.org/wiki?curid=1245250
788,221
214,939
The importance of Earth's magnetic field to the development of complex life has been disputed. The origin of Earth's magnetic field remains a mystery though the presence of a magnetosphere appears to be relatively common for larger planetary mass objects as all Solar System planets larger than Earth possess one. There is increasing evidence of present or past magnetic activity in terrestrial bodies such as the Moon, Ganymede, Mercury and Mars. Without sufficient measurement present studies rely heavily on modelling methods developed in 2006 by Olson & Christensen to predict field strength. Using a sample of 496 planets such models predict Kepler-186f to be one of few of Earth size that would support a magnetosphere (though such a field around this planet has not currently been confirmed). However current recent empirical evidence points to the occurrence of much larger and more powerful fields than those found in our Solar System, some of which cannot be explained by these models.
https://en.wikipedia.org/wiki?curid=827792
214,831
1,928,843
The mid-20th century saw a concerted movement to quantify and provide geometric models for various fields of science, including biology and physics. The geometrization of biology began in the 1950s in an effort to reduce concepts and principles of biology down into concepts of geometry similar to what was done in physics in the decades before. In fact, much of the geometrization that took place in the field of biology took its cues from the geometrization of contemporary physics. One major achievement in general relativity was the geometrization of gravitation. This allowed the trajectories of objects to be modeled as geodesic curves (or optimal paths) in a Riemannian space manifold. During the 1980s, the field of theoretical physics also witnessed an outburst of geometrization activity in parallel with the development of the Unified Field Theory, the Theory of Everything, and the similar Grand Unified Theory, all of which attempted to explain connections between known physical phenomena.
https://en.wikipedia.org/wiki?curid=20490055
1,927,738
1,143,641
In addition, a 22-amino acid sequence (flg22) of the conserved N-terminal part of flagellin is known to activate plant defence mechanisms. Flagellin perception in "Arabidopsis thaliana" functions via the receptor-like-kinase FLS2 (FLAGELLIN SENSING 2). Upon flg22 detection, FLS2 quickly binds to BAK1 (BRI1-associated kinase 1) to initiate signalling by reciprocal transphosphorylation of their kinase domains. Both flagellin and UV-C act similarly to increase homologous recombination, as demonstrated by Molinier et al 2006. Beyond this somatic effect, they found this to extend to subsequent generations of the plant. Mitogen-activated-protein-kinases (MAPK) acts as downstream signalling compounds, leading ultimately to PAMP-triggered immunity in which more than 900 genes are up-/down-regulated upon flg22 treatment.
https://en.wikipedia.org/wiki?curid=509654
1,143,041
566,672
After the demise of the Komnenoi, the Byzantine economy declined under the impact of several factors: the dismemberment of the Empire after 1204, the successive territorial losses to the Turks (although the strong economic interaction of Byzantine territories with those lost by the Empire continued), and the Italian expansion in the Mediterranean and the Black Sea. When Isaac II Angelos became Emperor in 1185, a mob broke into the palace and carried off pounds of gold, pounds of silver, and 20,000 pounds of bronze coins. In 1195, Holy Roman Emperor Henry VI forced Byzantine Emperor Alexios III Angelos to pay him a tribute of pounds of gold (originally pounds of gold) and in 1204 Alexios III took pounds of gold (or 72,000 "hyperpyra") when he fled Constantinople. The presence of the crusading army not only culminated in a violent sack that dispersed and destroyed the accumulated wealth, and culture of centuries, but was accompanied by a series of fires that ravaged the northern and central sections of the city resulting in a steady exodus of the city's residents to the Greek centers of government in exile. The sack of Constantinople by Latin crusaders in 1204 was an economic catastrophe. Due to the financial crisis, the state could only pay silver marks ( pounds of pure silver) out of silver marks (equivalent to 800,000 "hyperpyra") to the Crusaders in 1204. The official tally of plunder from Constantinople was about silver marks, the equivalent of about 3,600,000 "hyperpyra" or 50,000 pounds/22.5 tonnes of gold. The impoverished Latin emperors melted down statues for coin, while the Venetians exported their declining profits, along with choice relics and architecture spolia for their churches. In 1237, Latin Emperor Baldwin II pawned the Crown of Thorns to a Venetian merchant for gold coins.
https://en.wikipedia.org/wiki?curid=11418423
566,382
1,429,229
During the inquiry, Judge Harding-Clarke said that her offices were subject to three criminal forced entries. The judge also disclosed that 44 patient charts, 41 corresponding birth registers listing their babies' details, and a maternity theatre register, were stolen. Another theatre register was tampered with. Only the gynaecological register turned up - inexplicably - months after it was reported missing. They were "deliberately and unlawfully" removed, she wrote, "with a view to concealing the details of the operation performed and the treatment given. "Despite exhaustive research, judge Hardin-Clark never exposed the "miscreant/s" but she did suggest the involvement of women - at least two, one of whom wore nail varnish - and a possible motive of "misplaced loyalty" to Dr Neary. The bulk of the sabotage of patient files and medical records began in October 1998 when Dr Neary's alarming rate of hysterectomies first came to light. The Gardai launched an investigation into the missing files and in August 2005, the Director of Public Prosecutions directed that no prosecutions would be made.
https://en.wikipedia.org/wiki?curid=4733424
1,428,425
684,478
At the end of 1915, Rawlinson was considered for command of the First Army, in succession to Haig but the command was instead given to Sir Charles Monro. He was promoted to temporary general on 22 December 1915. Promoted to the substantive rank of lieutenant-general on 1 January 1916, Rawlinson assumed command of the new Fourth Army on 24 January 1916. The Fourth Army would play a major role in the planned Allied offensive on the Somme. He wrote in his diary: "It is not the lot of many men to command an army of over half a million men". The Somme was originally conceived as a joint Anglo-French offensive but owing to the demands of the Battle of Verdun, French participation was greatly reduced, leaving the British, and especially Rawlinson's inexperienced army, to bear the brunt of the offensive. On the eve of the offensive, he "showed an attitude of absolute confidence". To his diary he confided some uncertainties: "What the actual results will be no one can say but I feel pretty confident of success myself though only after heavy fighting. That the bosh [sic] will break and that a debacle will supervene I do not believe..." He was not satisfied that the wire was well cut and enemy trenches sufficiently "knocked about".
https://en.wikipedia.org/wiki?curid=889184
684,121
854,587
The heliograph had certain advantages. It allowed long distance communication without a fixed infrastructure, though it could also be linked to make a fixed network extending for hundreds of miles, as in the fort-to-fort network used for the Geronimo campaign. It was very portable, did not require any power source, and was relatively secure since it was invisible to those not near the axis of operation, and the beam was very narrow, spreading only 50 feet per mile of range. However, anyone in the beam with the correct knowledge could intercept signals without being detected. In the Boer War, where both sides used heliographs, tubes were sometimes used to decrease the dispersion of the beam. In some other circumstances, though, a narrow beam made it difficult to stay aligned with a moving target, as when communicating from shore to a moving ship, so the British issued a dispersing lens to broaden the heliograph beam from its natural diameter of 0.5 degrees to 15 degrees.
https://en.wikipedia.org/wiki?curid=712727
854,132
822,167
Lewis Thomas described in his memoir a physiologic experiment of 1941 in which he observed the prozone effect in vivo: immunity in rabbits to meningococcus, which was robust, unexpectedly decreased when immunization was used to induce a heightened antibody response. In other words, getting the rabbits' bodies to produce more antibodies against this bacterium had the counterproductive effect of decreasing their immunity to it. From the viewpoint of an overly simplistic notion of the antibody/antigen relationship, this seems paradoxical, although it is clearly logical from a viewpoint duly informed by present-day molecular biology. Thomas was interested in pursuing this physiologic research further, and remained so for decades afterward, but his career took him in other directions and he was not aware of anyone having pursued it by the time of his memoir. One kind of relevance that he hypothesized for this in vivo blocking antibody concept was as a driver of human susceptibility to certain infectious diseases. In the decades since, the concept has also been found to have clinical relevance in allergen immunotherapy, where blocking antibodies can interfere with other antibodies involved in hypersensitivity and thus improve allergy treatment.
https://en.wikipedia.org/wiki?curid=2264916
821,726
653,925
In the United States the first formal military satellite programs, Weapon System 117L, was developed in the mid 1950s. Within this program a number of sub-programs were developed including Corona. Satellites within the Corona program carried different code names. The first launches were code named Discoverer. This mission was a series of reconnaissance satellites, designed to enter orbit, take high-resolution photographs and then return the payload to Earth via parachute. Discoverer 1, the first mission, was launched on 28 February 1959 although it didn't carry a payload being intended as a test flight to prove the technology.} Corona was followed by other programs including Canyon (seven launches between 1968 and 1977), Aquacade and Orion (stated by US Government sources to be extremely large). There have also been a number of subsequent programs including Magnum and Trumpet, but these remain classified and therefore many details remain speculative.
https://en.wikipedia.org/wiki?curid=711123
653,581
405,664
In December 2001, VCEG and the Moving Picture Experts Group (MPEG – ISO/IEC JTC 1/SC 29/WG 11) formed a Joint Video Team (JVT), with the charter to finalize the video coding standard. Formal approval of the specification came in March 2003. The JVT was (is) chaired by Gary Sullivan, Thomas Wiegand, and Ajay Luthra (Motorola, U.S.: later Arris, U.S.). In July 2004, the Fidelity Range Extensions (FRExt) project was finalized. From January 2005 to November 2007, the JVT was working on an extension of H.264/AVC towards scalability by an Annex (G) called Scalable Video Coding (SVC). The JVT management team was extended by Jens-Rainer Ohm (RWTH Aachen University, Germany). From July 2006 to November 2009, the JVT worked on Multiview Video Coding (MVC), an extension of H.264/AVC towards 3D television and limited-range free-viewpoint television. That work included the development of two new profiles of the standard: the Multiview High Profile and the Stereo High Profile.
https://en.wikipedia.org/wiki?curid=237036
405,464
1,178,146
"Many technological systems, when examined for context and overall design, are basically anti-people," Franklin writes. "People are seen as sources of problems while technology is seen as a source of solutions." As a result, people live and work under conditions structured for the well-being of technology even though manufacturers and promoters always present new technologies as liberating. "The dreams of flight, of fast private transportation, of instant communication across continents, and of helpful machines, all stress liberation from hard physical labour at work or drudgery at home." But once technologies are accepted and standardized, they often enslave or displace their users. Franklin argues that work could be made less prescriptive in workplaces that are less rigidly hierarchical if we adopted more holistic practices based on the way women traditionally work in running households for example, or in caring for children.
https://en.wikipedia.org/wiki?curid=1094203
1,177,522
375,667
Under President Obama, the Office of nuclear energy stated in January 2012 that "Nuclear power has safely, reliably, and economically contributed almost 20% of electrical generation in the United States over the past two decades. It remains the single largest contributor (more than 70%) of non-greenhouse-gas- emitting electric power generation in the United States. Domestic demand for electrical energy is expected to grow by more than 30% from 2009 to 2035. At the same time, most of the currently operating nuclear power plants will begin reaching the end of their initial 20-year extension to their original 40-year operating license, for a total of 60 years of operation." It warned that if new plants do not replace those which are retired then the total fraction of generated electrical energy from nuclear power will begin to decline.
https://en.wikipedia.org/wiki?curid=4131402
375,472
962,521
IBM built the instrument unit at the Space Systems Center in Huntsville, Alabama. Located at the top of the S-IVB stage, it consisted of a Launch Vehicle Digital Computer (LVDC), an inertial platform, accelerometers, a tracking, telemetry and command system and associated environmental controls. It controlled the entire rocket from just before liftoff until battery depletion. Like other rocket guidance systems, it maintained its state vector (position and velocity estimates) by integrating accelerometer measurements, sent firing and steering commands to the main engines and auxiliary thrusters, and fired the appropriate ordnance and solid rocket motors during staging and payload separation events.
https://en.wikipedia.org/wiki?curid=551435
962,012
1,628,486
BCL11B is closely connected with immune regulation and for so its mutation can lead to a SCID phenotype. This so-called Immunodeficiency 49 (OMIM #617237) is classified as T-B+NK+ SCID. It is characterised by a lack of T lymphocytes and its malfunctioning specifically in proliferative response. On the other hand, B cells and NK cells counts and functions are not impaired. The symptoms of SCID caused by BCL11B mutation - apart from immunity defects - typically include teeth abnormalities, craniofacial dimorphism, different types of dermatitis. As well the intellectual development is significantly impaired. The disease has a very early onset and the only known treatment is hematopoietic stem cell transplantation from a healthy donor. The immunodeficiency has a dominant negative mode of inheritance as all so far described patients with it has been after sequencing identified as heterozygotes in the BCL11B gene.
https://en.wikipedia.org/wiki?curid=14881428
1,627,567
684,572
The method developed by Bjerrum is still the main method in use today, though the precision of the measurements has greatly increased. Most commonly, a solution containing the metal ion and the ligand in a medium of high ionic strength is first acidified to the point where the ligand is fully protonated. This solution is then titrated, often by means of a computer-controlled auto-titrator, with a solution of CO-free base. The concentration, or activity, of the hydrogen ion is monitored by means of a glass electrode. The data set used for the calculation has three components: a statement defining the nature of the chemical species that will be present, called the model of the system, details concerning the concentrations of the reagents used in the titration, and finally the experimental measurements in the form of titre and pH (or emf) pairs.
https://en.wikipedia.org/wiki?curid=20869108
684,215
911,448
The TerraMax UVG package is designed to be integrated into any tactical wheeled vehicle, and is fully incorporated into the brakes, steering, engine and transmission. Fitted vehicles retain the ability to be driver-operated. Vehicles manufactured by Oshkosh Defense and fitted with the package have competed in the DARPA Grand Challenges of 2004 and 2005, and the DARPA Urban Challenge of 2007. The Marine Corps Warfighting Lab selected TerraMax-equipped MTVRs for the Cargo UGV project initiated in 2010, culminating in a technology concept demonstration for the Office of Naval Research in 2015. Demonstrated uses for the upgraded vehicles include unmanned route clearance (with a mine roller) and reducing personnel required for transportation convoys.
https://en.wikipedia.org/wiki?curid=2253116
910,969
782,816
In spacecraft reaction wheel layout, a tetrahedral configuration of four wheels is commonly used. For wheels that perform equally (from a peak torque and max angular momentum standpoint) in both spin directions and across all four wheels, the maximum torque and maximum momentum envelopes for the 3-axis attitude control system (considering idealized actuators) are given by projecting the tesseract representing the limits of each wheel's torque or momentum into 3D space via the 3 × 4 matrix of wheel axes; the resulting 3D polyhedron is a rhombic dodecahedron. Such an arrangement of reaction wheels is not the only possible configuration (a simpler arrangement consists of three wheels mounted to spin about orthogonal axes), but it is advantageous in providing redundancy to mitigate the failure of one of the four wheels (with degraded overall performance available from the remaining three active wheels) and in providing a more convex envelope than a cube, which leads to less agility dependence on axis direction (from an actuator/plant standpoint). Spacecraft mass properties influence overall system momentum and agility, so decreased variance in envelope boundary does not necessarily lead to increased uniformity in preferred axis biases (that is, even with a perfectly distributed performance limit within the actuator subsystem, preferred rotation axes are not necessarily arbitrary at the system level).
https://en.wikipedia.org/wiki?curid=607631
782,397
774,456
By the 1980s, the world economic socialist system embraced one-third of the world's population but generated no more than 15 percent of global economic output. At its height in the mid-1980s, the world socialist system could be said to comprise the following countries with a "socialist orientation", though not all were allies of the Soviet Union: Afghanistan, Albania, Angola, Bulgaria, Cambodia, China, Cuba, Czechoslovakia, Eastern Germany, Ethiopia, Hungary, Mozambique, Nicaragua, North Korea, Laos, Mongolia, Poland, Romania, Vietnam, South Yemen, Yugoslavia and the Soviet Union. The system co-existed alongside the world capitalist system but was founded upon the principles of cooperation and mutual assistance rather than upon competition and rivalry. The countries involved aimed to even-out the level of economic development and to play an equal part in the international division of labour. An important role was played by the Council for Mutual Economic Assistance (CMEA) or Comecon, an international body set up to promote economic development. It involved joint planning activity, the establishment of international economic, scientific and technical bodies and methods of cooperation between state agencies and enterprises, including joint ventures and projects. Allied to the CMEA were the International Development Bank, established in 1971; and the International Bank for Economic Cooperation, founded in 1963, which had their counterparts in the World Bank, the Bank for International Settlements and the International Monetary Fund in the non-socialist world.
https://en.wikipedia.org/wiki?curid=43069513
774,040
1,324,916
The dorsal spines of "Orthacanthus platypternus" from the Craddock Bone Bed in Texas, USA, preserve a highly vascularized wall mainly composed of centrifugally growing dentine (the outer layer of the wall of the spine) in a succession of inwardly growing dentine layers that line the pulp cavity. These dentine layers are likely deposited periodically in accordance with seasonal variations in water temperature and food availability. More specifically, the periodic nature of the dentine layer deposits could be due to variation in calcium phosphate deposition following the changes in water temperature. Spines of individuals with 1-2 dentine layers are likely juveniles and result in the smallest sizes, whereas individuals showing at least 3-4 dentine layers result in two separate size classes. The cross section is oval near the opening of the pulp cavity and circular/subtriangular in the distal part of the non-denticulated region and circular in the denticulated region. The pulp cavity of the spine is filled with calcite, quartz, and opaque minerals.
https://en.wikipedia.org/wiki?curid=1205338
1,324,189
263,027
All modern computing platforms, however, use 16-, 32-, or 64-bit words, further divided into eight-bit bytes. On such systems three octal digits per byte would be required, with the most significant octal digit representing two binary digits (plus one bit of the next significant byte, if any). Octal representation of a 16-bit word requires 6 digits, but the most significant octal digit represents (quite inelegantly) only one bit (0 or 1). This representation offers no way to easily read the most significant byte, because it's smeared over four octal digits. Therefore, hexadecimal is more commonly used in programming languages today, since two hexadecimal digits exactly specify one byte. Some platforms with a power-of-two word size still have instruction subwords that are more easily understood if displayed in octal; this includes the PDP-11 and Motorola 68000 family. The modern-day ubiquitous x86 architecture belongs to this category as well, but octal is rarely used on this platform, although certain properties of the binary encoding of opcodes become more readily apparent when displayed in octal, e.g. the ModRM byte, which is divided into fields of 2, 3, and 3 bits, so octal can be useful in describing these encodings. Before the availability of assemblers, some programmers would handcode programs in octal; for instance, Dick Whipple and John Arnold wrote Tiny BASIC Extended directly in machine code, using octal.
https://en.wikipedia.org/wiki?curid=22330
262,888
219,885
The military has made the ADS available to the media for demonstrations on a number of occasions. A fully operational and mounted version of the system was demonstrated on January 24, 2007, at Moody Air Force Base in Georgia. A Reuters correspondent who volunteered to be shot with the beam during the demonstration described it as "similar to a blast from a very hot oven – too painful to bear without diving for cover." An Associated Press reporter who volunteered to be engaged stated "They certainly convinced me that the system could help save the lives of innocent civilians and our young service members". A CBS News correspondent did an in-depth story on ADS in March 2008. A demonstration was conducted for the media on March 9, 2012, at Marine Corps Base Quantico, Virginia.
https://en.wikipedia.org/wiki?curid=953399
219,776
1,644,511
Fruitbodies of "Leccinum holopus" have convex to flattened caps measuring in diameter, with a narrow band of sterile tissue surrounding the margin. The caps are initially whitish, but can develop gray, buff, tan, or pinkish tints during maturity; the color may also darken and become greenish with age. The cap surface is initially covered with very fine hairs, but later becomes more or less smooth, often with a sticky texture in age or in moist conditions. The flesh is white and lacks any distinct odor or taste; it can have either little or no bruising color reaction with injury, or may become light pink in variety "americanum". On the cap underside is a porous surface comprising pores numbering 2 to 3 per millimeter, each of which is the end of a tube that extends to deep. The color of the pore surface ranges from whitish to grayish to dingy brown, and has little color reaction to injury, although it may discolor yellowish or brownish. There is a depression where the pores meet the stipe. The stipe measures long by wide. Its whitish surface is covered with scabers that darken in age to tan or darker. The stipe base often stains bluish.
https://en.wikipedia.org/wiki?curid=45085136
1,643,584
919,252
In the US in the 2000s, companies and figures in the popular media have heavily marketed notions of "andropause" as something parallel to menopause; these notions have been rejected by the medical community. Additionally, advertising from drug companies selling testosterone and human growth hormone, as well as dietary supplement companies selling all kinds of "boosters" for aging men, have emphasized the "need" of middle-aged or ageing men for testosterone. There is a medical condition called late-onset hypogonadism; according to Thomas Perls and David J. Handelsman, writing in a 2015 editorial in the "Journal of the American Geriatrics Society", it appears that this condition is overdiagnosed and overtreated. Perls and Handelsman note that in the US, "sales of testosterone increased from $324 million in 2002 to $2 billion in 2012, and the number of testosterone doses prescribed climbed from 100 million in 2007 to half a billion in 2012, not including the additional contributions from compounding pharmacies, Internet, and direct-to-patient clinic sales."
https://en.wikipedia.org/wiki?curid=52251177
918,767
477,044
The AVERE / European Association for Battery, Hybrid and Fuel Cell Electric Vehicles was founded back in 1978 and is a member of the World Electric Vehicle Association. AVERE is also the parent organization of CITELEC / Association of European Cities interested in Electric Vehicles and Eurelectric. The European Commission has funded the "Green Cars Initiative" since November 2008. In March 2011, the European Commission along with forty two partners from the industries, utilities, electric car manufacturers, municipalities, universities and technology and research institutions founded the "Green eMotion" initiative funded with €41.8 million under the Seventh Research and Development Framework Programme. The defined goal is to provide an interoperable electromobility framework to align the ongoing regional and national electromobility initiatives. At the same time the partners unveiled the "Transport 2050" plan which includes the aim to half the number of conventionally fuelled cars in cities by 2030 and phase them out by 2050.
https://en.wikipedia.org/wiki?curid=21079741
476,804
1,084,424
In 2019 the Islamic Republic News Agency reported that the "Fateh" had joined Iran's fleet after final tests, in a ceremony attended by Iranian president Hassan Rouhani. It reported that the "Fateh" is "equipped with sonar, electric drive, combined battle management, surface-to-surface guided missile guidance, torpedo guidance, electronic and telecommunication warfare, secure and integrated telecommunication systems and dozens of state-of-the-art modern systems. Fateh submarine has surface speed of 11 knots (20.35 km/h) and is capable of travelling submerged at 14 knots (25.9 km/h). The submarine is armed with four 533-mm torpedoes; it can carry eight sea mines and two reserve torpedoes."
https://en.wikipedia.org/wiki?curid=35322652
1,083,867
787,876
As computers have become more powerful, the size of the initial data sets has increased and newer atmospheric models have been developed to take advantage of the added available computing power. These newer models include more physical processes in the simplifications of the equations of motion in numerical simulations of the atmosphere. In 1966, West Germany and the United States began producing operational forecasts based on primitive-equation models, followed by the United Kingdom in 1972 and Australia in 1977. The development of limited area (regional) models facilitated advances in forecasting the tracks of tropical cyclones as well as air quality in the 1970s and 1980s. By the early 1980s models began to include the interactions of soil and vegetation with the atmosphere, which led to more realistic forecasts.
https://en.wikipedia.org/wiki?curid=1505381
787,452
1,247,268
Kinoshita included in his objectives “to see whether a single 𝛂-particle produced a detectable photographic event”. His method was to expose the emulsion to radiation from a well measured radioactive source, for which the emission rate of 𝛂-particles was known. He used that knowledge and the relative proximity of the plate to the source, to compute the number of 𝛂-particles expected to traverse the plate. He compared that number with the number of developed halide grains he counted in the emulsion, taking careful account of 'background radiation' that produced additional 'non-alpha' grains in the exposure. He completed this research project in 1909, showing that it was possible “by preparing an emulsion film of very fine silver halide grains, and by using a microscope of high magnification, that the photographic method can be applied for counting 𝛂-particles with considerable accuracy”. This was the first time that the observation of individual charged particles by means of a photographic emulsion had been achieved. However, that was the detection of individual particle impacts, not the observation of a particle's extended trajectory. Soon after that, in 1911, Max Reinganum showed that the passage of an 𝛂-particle at glancing incidence through a photographic emulsion produced, when the emulsion was developed, a row of silver halide grains outlining the trajectory of the 𝛂-particle; the first recorded observation of an extended particle track in an emulsion.
https://en.wikipedia.org/wiki?curid=9769489
1,246,593
449,376
Maximum parsimony is an epistemologically straightforward approach that makes few mechanistic assumptions, and is popular for this reason. However, it may not be statistically consistent under certain circumstances. Consistency, here meaning the monotonic convergence on the correct answer with the addition of more data, is a desirable property of statistical methods. As demonstrated in 1978 by Joe Felsenstein, maximum parsimony can be inconsistent under certain conditions. The category of situations in which this is known to occur is called "long branch attraction", and occurs, for example, where there are long branches (a high level of substitutions) for two characters (A & C), but short branches for another two (B & D). A and B diverged from a common ancestor, as did C and D. Of course, to know that a method is giving you the wrong answer, you would need to know what the correct answer is. This is generally not the case in science. For this reason, some view statistical consistency as irrelevant to empirical phylogenetic questions.
https://en.wikipedia.org/wiki?curid=1130020
449,158
1,257,287
The ISS year-long mission was an 11-month-long scientific research project aboard the International Space Station, which studied the health effects of long-term spaceflight. Astronaut Scott Kelly (ideally suited for the experiment as the identical twin of Mark Kelly) and cosmonaut Mikhail Kornienko spent 340 days in space, with scientists performing medical experiments. Kelly and Kornienko launched on 27 March 2015 on Soyuz TMA-16M along with Gennady Padalka. The mission encompassed Expeditions 43, 44, 45 and 46. The pair safely landed in Kazakhstan on March 2, 2016, returning aboard Soyuz TMA-18M with Sergey Volkov. The mission supported the NASA Twins study, which helps shed light on the health effects of long-duration spaceflight, which is of interest for Mars missions especially.
https://en.wikipedia.org/wiki?curid=46246471
1,256,601
1,378,882
Fullbore Target Rifle involves prone position single shot precision shooting using adjustable aperture sights at 'round bull' targets at distances from 300 to 1000 yards, with each shot being carefully scored and analysed. The usual calibre used was .303 British (standard military) up to the late 1950s when the NATO countries adopted the .308 Winchester/7.62×51mm NATO as the new military interoperable choice of ammunition. Under ICFRA Rules, .223 Remington/5.56x45 NATO is permitted as an alternative. However, many matches such as the NRA Imperial Meeting require competitors to use issued ammunition - which is typically only offered in .308. The .303 British calibre is still in use by Service Rifle shooters and was exclusively used by Fullbore in the Short, Magazine Lee–Enfield (SMLE) No.1 Mk. III and Lee-Enfield No. 4 rifles.
https://en.wikipedia.org/wiki?curid=4254897
1,378,120
61,936
In North America, "Smilodon" hunted large herbivores such as bison and camels, and it remained successful even when encountering new prey species in South America. "Smilodon" is thought to have killed its prey by holding it still with its forelimbs and biting it, but it is unclear in what manner the bite itself was delivered. Scientists debate whether "Smilodon" had a social or a solitary lifestyle; analysis of modern predator behavior as well as of "Smilodon"s fossil remains could be construed to lend support to either view. "Smilodon" probably lived in closed habitats such as forests and bush, which would have provided cover for ambushing prey. "Smilodon" died out at the same time that most North and South American megafauna disappeared, about 10,000 years ago. Its reliance on large animals has been proposed as the cause of its extinction, along with climate change and competition with other species, but the exact cause is unknown.
https://en.wikipedia.org/wiki?curid=169071
61,911
1,283,659
Assigning Phases I and II to Phylakopi II, Edgar attempted to make a case that it evolved from the earlier geometric by a sort of "freeing" of the patterns from repetitive geometric forms to obtain a "looser system." He called it "early Mycenaean" (as opposed to geometric "pre-Mycenaean"). Phases 3 and 4 were to be assigned entirely to Phylakopi III. They were termed "The Later Local Pottery of the Mycenaean Period." Edgar concedes that they were swimming in deeper waters, so to speak, than originally planned. He makes a noble effort to connect Phase 3 with the geometric, but the complexities of Phase 4 are far beyond his comparisons. He gives up, remarking "The fourth and final stage of the Phylakopi settlement is marked by predominance of imported Mycenaean ware ...," which reflects a general realization by the British School that Phylakopi does not contain the answer to the riddle of Mycenaean provenance. They decide to abandon Phylakopi in favor of the most likely source of the imports, Crete.
https://en.wikipedia.org/wiki?curid=14946338
1,282,961
1,832,034
By focusing on strengthening scientific research, Changsha University commits itself to improving teaching and fostering a growing atmosphere for teachers’ research and innovation. It has set up 5 research institutes, namely Research of Changsha Culture, Research Institute of Higher Education, Research Institute of Mathematics and Research Institute of Biological Technology, and 1 key laboratory of Cell Engineering. Since 2000, the teaching staff have undertaken 2 projects of the State Science Fund and 1 special project of Youth's Fund subsidized by Ministry of Education, published 3,000 treatises in the provincial or national periodicals, 98 of which were quoted by SCI and EI, 23 of which were reprinted by Xinhua Digest, Periodicals of National People's Congress, etc. In May 2005, “Study of Post-war Britain Peaceful Movement”(by Pro.Xiong Weimin ) won State Social Science Fund, together with “Research on Study-oriented Society and Study Innovation and Creativity of College Students”(by Pro.Qu Linyan ) conferred as a key subject of “The 10th 5-Year Plan” of State Education Science in 2003, indicates that the research on humanities and social science in our university has already approached the national level.
https://en.wikipedia.org/wiki?curid=37272729
1,830,987
451,148
This is an approach to music synthesis that involves "translating" information from an existing non-musical medium into a new sound. The translation can be either rule-based or stochastic. For example, when translating a picture into sound, a jpeg image of a horizontal line may be interpreted in sound as a constant pitch, while an upwards-slanted line may be an ascending scale. Oftentimes, the software seeks to extract concepts or metaphors from the medium, (such as height or sentiment) and apply the extracted information to generate songs using the ways music theory typically represents those concepts. Another example is the translation of text into music, which can approach composition by extracting sentiment (positive or negative) from the text using machine learning methods like sentiment analysis and represents that sentiment in terms of chord quality such as minor (sad) or major (happy) chords in the musical output generated.
https://en.wikipedia.org/wiki?curid=479884
450,929
349,215
The law tends to break down at very high concentrations, especially if the material is highly scattering. Absorbance within range of 0.2 to 0.5 is ideal to maintain linearity in the Beer–Lambart law. If the radiation is especially intense, nonlinear optical processes can also cause variances. The main reason, however, is that the concentration dependence is in general non-linear and Beer's law is valid only under certain conditions as shown by derivation below. For strong oscillators and at high concentrations the deviations are stronger. If the molecules are closer to each other interactions can set in. These interactions can be roughly divided into physical and chemical interactions. Physical interaction do not alter the polarizability of the molecules as long as the interaction is not so strong that light and molecular quantum state intermix (strong coupling), but cause the attenuation cross sections to be non-additive via electromagnetic coupling. Chemical interactions in contrast change the polarizability and thus absorption.
https://en.wikipedia.org/wiki?curid=4476
349,033
755,548
The RING motif, a Zn finger found in eukaryotic peptides, is 40–60 amino acids long and consists of eight conserved metal-binding residues, two quartets of cysteine or histidine residues that coordinate two zinc atoms. This motif contains a short anti-parallel beta-sheet, two zinc-binding loops and a central alpha helix in a small domain. This RING domain interacts with associated proteins, including BARD1, which also contains a RING motif, to form a heterodimer. The BRCA1 RING motif is flanked by alpha helices formed by residues 8–22 and 81–96 of the BRCA1 protein. It interacts with a homologous region in BARD1 also consisting of a RING finger flanked by two alpha-helices formed from residues 36–48 and 101–116. These four helices combine to form a heterodimerization interface and stabilize the BRCA1-BARD1 heterodimer complex. Additional stabilization is achieved by interactions between adjacent residues in the flanking region and hydrophobic interactions. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression.
https://en.wikipedia.org/wiki?curid=412097
755,145
974,885
Radiofrequency ablation has been shown to be a safe and effective treatment for Barrett's esophagus. The balloon-based radiofrequency procedure was invented by Robert A. Ganz, Roger Stern and Brian Zelickson in 1999 (System and Method for Treating Abnormal Tissue in the Human Esophagus). While the person is sedated, a catheter is inserted into the esophagus and radiofrequency energy is delivered to the diseased tissue. This outpatient procedure typically lasts from fifteen to thirty minutes. Two months after the procedure, the physician performs an upper endoscopic examination to assess the esophagus for residual Barrett's esophagus. If any Barrett's esophagus is found, the disease can be treated with a focal RFA device. Between 80 and 90% or greater of people in numerous clinical trials have shown complete eradication of Barrett's esophagus in approximately two to three treatments with a favorable safety profile. The treatment of Barrett's esophagus by RFA is durable for up to 5 years.
https://en.wikipedia.org/wiki?curid=3222160
974,374
1,040,724
A small fraction of the peptide (usually 1 microliter or less) is pipetted onto a MALDI target and a chemical called a matrix is added to the peptide mix. Common matrices are Sinapinic acid, Alpha-Cyano-4-hydroxycinnamic acid, and 2,3-Dihydroxybenzoic acid. The matrix molecules are required for the desorption of the peptide molecules. Matrix and peptide molecules co-crystallize on the MALDI target and are ready to be analyzed. There is one predominantly MALDI-MS sample preparation technique, namely dried droplet technique. The target is inserted into the vacuum chamber of the mass spectrometer and the desorption and ionisation of the polypeptide fragments is initiated by a pulsed laser beam which transfers high amounts of energy into the matrix molecules. The energy transfer is sufficient to promote the ionisation and transition of matrix molecules and peptides from the solid phase into the gas phase. The ions are accelerated in the electric field of the mass spectrometer and fly towards an ion detector where their arrival is detected as an electric signal. Their mass-to-charge ratio is proportional to their time of flight (TOF) in the drift tube and can be calculated accordingly.
https://en.wikipedia.org/wiki?curid=1983032
1,040,181
787,898
On a molecular scale, there are two main competing reaction processes involved in the degradation of cellulose, or wood fuels, in wildfires. When there is a low amount of moisture in a cellulose fiber, volatilization of the fuel occurs; this process will generate intermediate gaseous products that will ultimately be the source of combustion. When moisture is present—or when enough heat is being carried away from the fiber, charring occurs. The chemical kinetics of both reactions indicate that there is a point at which the level of moisture is low enough—and/or heating rates high enough—for combustion processes to become self-sufficient. Consequently, changes in wind speed, direction, moisture, temperature, or lapse rate at different levels of the atmosphere can have a significant impact on the behavior and growth of a wildfire. Since the wildfire acts as a heat source to the atmospheric flow, the wildfire can modify local advection patterns, introducing a feedback loop between the fire and the atmosphere.
https://en.wikipedia.org/wiki?curid=1505381
787,474
647,877
Another issue with WIMP-style user interfaces is that many implementations put users with disabilities at a disadvantage. For example, visually impaired users may have difficulty using applications when alternative text-based interfaces are not made available. People with motor impairments, such as Parkinson's disease, may not be able to navigate devices precisely using the traditional mouse pointer for input. To overcome these barriers, researchers continue to explore ways to make modern computer systems more accessible. Recent developments in artificial intelligence, specifically machine learning, have opened new doors for accessibility in technology, or assistive technology.
https://en.wikipedia.org/wiki?curid=550454
647,537
865,414
Medical studies suggest a relation between ICU volume and quality of care for mechanically ventilated patients. After adjustment for severity of illness, demographic variables, and characteristics of the ICUs (including staffing by intensivists), higher ICU volume was significantly associated with lower ICU and hospital mortality rates. For example, adjusted ICU mortality (for a patient at average predicted risk for ICU death) was 21.2% in hospitals with 87 to 150 mechanically ventilated patients annually, and 14.5% in hospitals with 401 to 617 mechanically ventilated patients annually. Hospitals with intermediate numbers of patients had outcomes between these extremes. ICU delirium, formerly and inaccurately referred to as ICU psychosis, is a syndrome common in intensive care and cardiac units where patients who are in unfamiliar, monotonous surroundings develop symptoms of delirium (Maxmen & Ward, 1995). This may include interpreting machine noises as human voices, seeing walls quiver, or hallucinating that someone is tapping them on the shoulder. There exists systematic reviews in which interventions of sleep promotion related outcomes in the ICU have proven impactful in the overall health of patients in the ICU.
https://en.wikipedia.org/wiki?curid=299014
864,954
1,770,015
The preproduction team also tweaked the game systems. They chose a skill system that used nanotechnology augmentation, unique to the player character, as "special powers" instead of "die-rolls" or skills that required granular management. They also built a conversation structure based on console role-playing game setups, and drafted the augmentation upgrade, inventory, and skill screens. They also designed an in-game text editor for taking notes, and "reward systems" for skill points, reduced weapon and tool cooldowns, and augmentation upgrades. Preproduction had generated 300 pages of documentation by March 1998. The document grew to 500 pages with "radically different" content by their April 1999 Alpha 1 deadline. Of Spector's original design document, the marketing section was the only part left unedited.
https://en.wikipedia.org/wiki?curid=43210943
1,769,020
1,172,108
Monte Carlo N-Particle Transport (MCNP) is a general-purpose, continuous-energy, generalized-geometry, time-dependent, Monte Carlo radiation transport code designed to track many particle types over broad ranges of energies and is developed by Los Alamos National Laboratory. Specific areas of application include, but are not limited to, radiation protection and dosimetry, radiation shielding, radiography, medical physics, nuclear criticality safety, detector design and analysis, nuclear oil well logging, accelerator target design, fission and fusion reactor design, decontamination and decommissioning. The code treats an arbitrary three-dimensional configuration of materials in geometric cells bounded by first- and second-degree surfaces and fourth-degree elliptical tori.
https://en.wikipedia.org/wiki?curid=2479157
1,171,489
594,874
The structures of both eukaryotic and prokaryotic genes involve several nested sequence elements. Each element has a specific function in the multi-step process of gene expression. The sequences and lengths of these elements vary, but the same general functions are present in most genes. Although DNA is a double-stranded molecule, typically only one of the strands encodes information that the RNA polymerase reads to produce protein-coding mRNA or non-coding RNA. This 'sense' or 'coding' strand, runs in the 5' to 3' direction where the numbers refer to the carbon atoms of the backbone's ribose sugar. The open reading frame (ORF) of a gene is therefore usually represented as an arrow indicating the direction in which the sense strand is read.
https://en.wikipedia.org/wiki?curid=4681639
594,569
147,203
Zebrafish have been used as model organisms for bone metabolism, tissue turnover, and resorbing activity. These processes are largely evolutionary conserved. They have been used to study osteogenesis (bone formation), evaluating differentiation, matrix deposition activity, and cross-talk of skeletal cells, to create and isolate mutants modeling human bone diseases, and test new chemical compounds for the ability to revert bone defects. The larvae can be used to follow new ("de novo") osteoblast formation during bone development. They start mineralising bone elements as early as 4 days post fertilisation. Recently, adult zebrafish are being used to study complex age related bone diseases such as osteoporosis and osteogenesis imperfecta. The (elasmoid) scales of zebrafish function as a protective external layer and are little bony plates made by osteoblasts. These exoskeletal structures are formed by bone matrix depositing osteoblasts and are remodeled by osteoclasts. The scales also act as the main calcium storage of the fish. They can be cultured ex-vivo (kept alive outside of the organism) in a multi-well plate, which allows manipulation with drugs and even screening for new drugs that could change bone metabolism (between osteoblasts and osteoclasts).
https://en.wikipedia.org/wiki?curid=5009
147,145
1,140,628
The first Cradle of Aviation Museum Newsletters were published periodically by the Friends of Nassau County Museum when the air museum itself was still just a dream of Kaiser and George C. Dade, the museum's first director. Along with Henry Anholzer of Pan American Airlines and a team of volunteers, they acquired and restored numerous aircraft. These aircraft reflected some of Long Island's "aviation firsts" and its local aerospace industry. The first acquisition was a World War I Curtiss JN-4D discovered in an Iowa pig barn by Dade in 1973. Apparently, Lindbergh later confirmed that this was his very first airplane. According to their Spring 1979 newsletter, the museum also had a Ryan Brougham (sister ship of the "Spirit of St. Louis"), Republic P-47N Thunderbolt, Republic Seabee, Grumman F-11A Tiger, and a Grumman Lunar Module spacecraft. These aircraft were destined to occupy hangars 3 & 4 of Mitchel Air Force Base which was acquired by Nassau County when the base closed in 1961. The museum originally opened with just a handful of aircraft in the un-restored hangars in 1980. A major renovation and expansion program in the late 1990s allowed the museum to re-open in a state-of-the-art facility in 2002.
https://en.wikipedia.org/wiki?curid=3472027
1,140,034
1,649,866
The characteristic features of TRC are its thin structure and malleable nature, as well as its ability to retain a high tensile strength; this is due to reinforcement in the concrete that uses long continuous fibers that are woven in a specific direction in order to add strength. As the result of the varying strength and properties needed to support correct loading, there are many different types of yarns, textiles weaves, and shapes that can be used in TRC. The textile begins with a yarn that is made of a continuous strand of either filaments or staples. The yarn is woven, knit, glued, braided or is left non-woven, depending on the needs of the project. Carbon, AR glass, and basalt are especially good materials for this process. Carbon has good tensile strength and low heat expansion, but is costly and has bad adhesion to concrete. Basalt is formed by melting basalt rock; it is more cost effective than carbon, and has a good tensile strength. The drawback of basalt is when it is placed in an alkali solution, such as concrete, it loses some of its volume of fibers, thus reducing its strength. This means a nano composite polymer coating must be applied to increase the longevity of the construction. AR glass has this problem, as well, but the positives of using AR glass in TRC structure, including its adhesion to concrete and low cost, outweigh these issues.
https://en.wikipedia.org/wiki?curid=23092691
1,648,934
162,188
During the "golden age" of the 1950s and 1960s, unemployment in Britain averaged only 2%. As prosperity returned, Britons became more family centred. Leisure activities became more accessible to more people after the war. Holiday camps, which had first opened in the 1930s, became popular holiday destinations in the 1950s – and people increasingly had the money to pursue their personal hobbies. The BBC's early television service was given a major boost in 1952 with the coronation of Elizabeth II, attracting a worldwide audience of twenty million, plus tens of millions more by radio, proving an impetus for middle-class people to buy televisions. In 1950, just 1% owned television sets; by 1965 25% did. As austerity receded after 1950 and consumer demand kept growing, the Labour Party hurt itself by shunning consumerism as the antithesis of the socialism it demanded.
https://en.wikipedia.org/wiki?curid=33643110
162,103
534,273
At the first dual meet of her collegiate career, a double dual meet against the Indiana Hoosiers and the Texas A&M Aggies on October 21 her freshman year (first year), Jacoby placed second in the 100-yard breaststroke with a time of 59.93 seconds and third in the 200-yard breaststroke with a time of 2:11.31 for her individual events to help her team, the Texas Longhorns, win both dual meets. Seven days later, in the morning preliminaries of the 200-meter breaststroke at the 2022 Swimming World Cup in Toronto, Canada, Jacoby qualified for the final ranking seventh with a personal best time of 2:24.23, which marked a drop of 0.76 seconds from her previous best time of 2:24.99. Approximately 40 minutes later, she swam a personal best time of 1:04.68 in the 100-meter individual medley and placed twenty-seventh. In the evening final of the 200-meter breaststroke, she dropped 1.87 seconds from her personal best time in the morning session, placing sixth with a time of 2:22.36. The following morning, she swam a personal best time of 1:04.70 in the preliminaries of the 100-meter breaststroke, lowering her former personal best time by 0.50 seconds and qualifying for the final ranking third. She further improved her personal best time in the final, placing fourth with a time of 1:04.62 that was 1.67 seconds slower than gold medalist and 2012 Olympic champion at 15 years of age in the 100-meter breaststroke Rūta Meilutytė of Lithuania.
https://en.wikipedia.org/wiki?curid=67608890
533,994
2,091,338
CAPS also is leading an NSF Large Information Technology Research (ITR) grant that seeks to develop an infrastructure for mesoscale meteorology research and education. Known as Linked Environments for Atmospheric Discovery (LEAD), a transforming element of this project is the ability for analysis tools, forecast models, and data repositories to function as dynamically adaptive, on-demand systems that can change configuration rapidly and automatically in response to the evolving weather; respond immediately to user decisions based upon the weather problem at hand; and steer remote observing systems to optimize data collection and forecast/warning quality.
https://en.wikipedia.org/wiki?curid=5620935
2,090,134
937,753
A gyroscope, not to be confused with a gyrocompass, is a spinning wheel mounted on a set of gimbals so that its axis is free to orient itself in any way. When it is spun up to speed with its axis pointing in some direction, due to the law of conservation of angular momentum, such a wheel will normally maintain its original orientation to a fixed point in outer space (not to a fixed point on Earth). Since the Earth rotates, it appears to a stationary observer on Earth that a gyroscope's axis is completing a full rotation once every 24 hours. Such a rotating gyroscope is used for navigation in some cases, for example on aircraft, where it is known as heading indicator or directional gyro, but cannot ordinarily be used for long-term marine navigation. The crucial additional ingredient needed to turn a gyroscope into a gyrocompass, so it would automatically position to true north, is some mechanism that results in an application of torque whenever the compass's axis is not pointing north.
https://en.wikipedia.org/wiki?curid=45832
937,253
737,036
In 2008, IBM representatives communicated with "Jeopardy!" executive producer Harry Friedman about the possibility of having Watson compete against Ken Jennings and Brad Rutter, two of the most successful contestants on the show, and the program's producers agreed. Watson's differences with human players had generated conflicts between IBM and "Jeopardy!" staff during the planning of the competition. IBM repeatedly expressed concerns that the show's writers would exploit Watson's cognitive deficiencies when writing the clues, thereby turning the game into a Turing test. To alleviate that claim, a third party randomly picked the clues from previously written shows that were never broadcast. "Jeopardy!" staff also showed concerns over Watson's reaction time on the buzzer. Originally Watson signalled electronically, but show staff requested that it press a button physically, as the human contestants would. Even with a robotic "finger" pressing the buzzer, Watson remained faster than its human competitors. Ken Jennings noted, "If you're trying to win on the show, the buzzer is all", and that Watson "can knock out a microsecond-precise buzz every single time with little or no variation. Human reflexes can't compete with computer circuits in this regard." Stephen Baker, a journalist who recorded Watson's development in his book "Final Jeopardy", reported that the conflict between IBM and "Jeopardy!" became so serious in May 2010 that the competition was almost cancelled. As part of the preparation, IBM constructed a mock set in a conference room at one of its technology sites to model the one used on "Jeopardy!". Human players, including former "Jeopardy!" contestants, also participated in mock games against Watson with Todd Alan Crain of "The Onion" playing host. About 100 test matches were conducted with Watson winning 65% of the games.
https://en.wikipedia.org/wiki?curid=22584291
736,647
173,681
In late July 2010, Antonov suspended the flight test programme to update the aircraft. After an extensive series of modifications, including revised avionics (which reduced the flight crew from five to four) and changes to the aircraft's propellers to improve reliability and decrease noise, the second prototype An-70 flew again on 27 September 2012 and took part in the Aviasvit XXI airshow in Kyiv. During the same year, Russian and Ukrainian authorities agreed on the basic workshare of the production programme. Antonov in Kyiv would now produce the wings, tail surfaces and engine nacelles. The KAPO factory in Kazan, Russia, would be responsible for the manufacture of the fuselage, the final assembly of the aircraft, and flight testing. Other major components would come from Novosibirsk, Ulyanovsk and Voronezh; construction of the fuselage of the first production aircraft was reportedly complete in December 2012.
https://en.wikipedia.org/wiki?curid=908224
173,590
1,323,388
Surfactants play an important role in droplet-based microfluidics. The main purpose of using a surfactant is to reduce the interfacial tension between the dispersed phase (droplet phase, typically aqueous) and continuous phase (carrier liquid, typically oil) by adsorbing at interfaces and preventing droplets from coalescing with each other, therefore stabilizing the droplets in a stable emulsion state, which allows for longer storage times in delay-lines, reservoirs, or vials. Without using surfactants, the unstable emulsions will eventually evolve into separate phases to reduce the overall energy of the system. Surface chemistry cannot be ignored in microfluidics as the interfacial tension becomes a major consideration among microscale droplets. Linas Mazutis and Andrew D. Griffiths presented a method that used surfactants to achieve a selective and highly controllable coalescence without external manipulation. They manipulate the contact time and the interfacial surfactant coverage of a drop pair to control droplet fusion. The larger the difference percentage of the interfacial surfactant coverage between two droplets, the less likely coalescence will occur. This method allowed researchers to add reagents to droplets in a different way and further study the emulsification.
https://en.wikipedia.org/wiki?curid=54022162
1,322,662
1,886,578
Science includes research into the processes that maintain New Zealand's ecosystems, enable natural flora, fauna and fungi to flourish, and protect soil and catchments for a range of production and other purposes. The impacts of disruption to ecosystems; biosecurity risks from foreign weeds, pests and micro-organisms; and contamination to land, water and air caused by the production of natural, manufactured or waste compounds are investigated. Research is also undertaken to develop tools to help mitigate inefficient resource use and excess waste, and systems designed to improve resource use productivity, lifestyle and business viability. Research focuses on six key areas:
https://en.wikipedia.org/wiki?curid=1515877
1,885,496
949,066
An early (retroactively) RISC-"labeled" processor (IBM 801 IBM's Watson Research Center, mid-1970s) was a tightly pipelined simple machine originally intended to be used as an internal microcode kernel, or engine, in CISC designs, but also became the processor that introduced the RISC idea to a somewhat larger audience. Simplicity and regularity also in the visible instruction set would make it easier to implement overlapping processor stages (pipelining) at the machine code level (i.e. the level seen by compilers). However, pipelining at that level was already used in some high-performance CISC "supercomputers" in order to reduce the instruction cycle time (despite the complications of implementing within the limited component count and wiring complexity feasible at the time). Internal microcode execution in CISC processors, on the other hand, could be more or less pipelined depending on the particular design, and therefore more or less akin to the basic structure of RISC processors.
https://en.wikipedia.org/wiki?curid=7622
948,562
84,358
Temple no. 3 (also termed Sariputta Stupa) is the most iconic of Nalanda's structures with its multiple flights of stairs that lead all the way to the top. The temple was originally a small structure which was built upon and enlarged by later constructions. Archaeological evidence shows that the final structure was a result of at least seven successive such accumulations of construction. The fifth of these layered temples is the most interesting and the best preserved with four corner towers of which three have been exposed. The towers as well as the sides of the stairs are decorated with exquisite panels of Gupta-era art depicting a variety of stucco figures including Buddha and the Bodhisattvas, scenes from the Jataka tales. The temple is surrounded by numerous votive stupas some of which have been built with bricks inscribed with passages from sacred Buddhist texts. The apex of Temple no. 3 features a shrine chamber which now only contains the pedestal upon which an immense statue of Buddha must have once rested. According to Win Maung, the stupa was influenced by Gupta architecture, which itself had Kushana era influences. In a shrine near the bottom of the staircase, a large image of Avalotiteshvar was found which was eventually moved to the Museum.
https://en.wikipedia.org/wiki?curid=200282
84,324
1,280,990
Research has investigated how to improve the accuracy of earwitness performance. One study investigated whether an interview called a Cognitive Interview would improve adult or child (11–13 years) voice recognition performance or speech content recall if it was administered immediately after the event. It was predicted that a cognitive interview would improve the likelihood of witnesses making a correct identification and improve recall of speech content, whether immediately after the event of after a time-delay and regardless of age. It was also predicted that adults would recall more content than children, because other studies have indicated that children provide less detail than adults during free recall. However, results revealed poor correct identification rates, regardless of the type of interview earwitnesses had received (19.8%), as well as high false identification rates; 38.7% of participants incorrectly identified an innocent suspect. It did not seem to matter if an interview had been conducted shortly after the event or not. Moreover, there did not seem to be any difference between children and adults in terms of the number of suspects they correctly identified by their voice. Many researchers would suggest that this furthers the case for children (aged 11–13) to be thought of as equally capable of proving potentially helpful earwitness accounts within court settings.
https://en.wikipedia.org/wiki?curid=33106906
1,280,295
2,189,130
One example of a significant bridge was the Beaumont road bridge over the Clutha River, which is also known as the Dunkeld Bridge, as this was the original survey name for the township that soon took the name of Beaumont. The bridge was opened by John Anderson Jr. on 4 March 1887 with a champagne lunch. A champagne lunch of such proportions that the location for the presentation is still called Champagne Flat was held at the opening of the Waiau Ferry Bridge, these days a Category I heritage item registered with Heritage New Zealand. Another early and outstanding bridge was the Waiteti Viaduct, the northernmost viaduct on the North Island Main Trunk railway a few kilometres south of Te Kuiti. This structure was also completed in 1887. Probably the most significant structure on the North Island Main Trunk Railway is the Makatote Viaduct south of National Park. At , it is the highest on this line. It took three years to build and Andrew Anderson moved his family to the construction village, so that he could oversee the work. The viaduct was commissioned in 1908. The company diversified by importing engines, locomotives, they built steam engines, and started building oil storage tanks once the importation of oil began.
https://en.wikipedia.org/wiki?curid=53723160
2,187,881
1,872,229
Superstition was essential to the Samnite culture. They practiced augury and believed magic could influence the world. Ceremonies would be performed at weddings to promote fertility and bring good fortune. Priests and important politicians such as the "Meddix" and "Meddix Tuticus" were involved in these rituals. Priests also defined the limits to sanctuaries and kept records. The "Seviri Augustales" were likely based on Samnite priests. Clothing was also an aspect of Samnite religion. They believed that magical amulets could protect their owners from harm. These amulets were usually made from expensive materials that showcased wealth. Like beads or pendants. They were also usually given to young women that were old enough to bear children. Depictions of people worshipping at the Samnite sanctuary of Pietrabbondante showcase them wearing veils, capes, and a head ornament resembling a polos. It is common for these worshippers to also hold objects. Such as focaccia or bronze goblets. Red paint was also used to decorate the faces of people whilst they chanted. These chants were common at harvests, festivals, and marriages.
https://en.wikipedia.org/wiki?curid=70238954
1,871,152
299,355
A possible improvement to decoding is to keep a set of good candidates instead of just keeping the best candidate, and to use a better scoring function (re scoring) to rate these good candidates so that we may pick the best one according to this refined score. The set of candidates can be kept either as a list (the N-best list approach) or as a subset of the models (a lattice). Re scoring is usually done by trying to minimize the Bayes risk (or an approximation thereof): Instead of taking the source sentence with maximal probability, we try to take the sentence that minimizes the expectancy of a given loss function with regards to all possible transcriptions (i.e., we take the sentence that minimizes the average distance to other possible sentences weighted by their estimated probability). The loss function is usually the Levenshtein distance, though it can be different distances for specific tasks; the set of possible transcriptions is, of course, pruned to maintain tractability. Efficient algorithms have been devised to re score lattices represented as weighted finite state transducers with edit distances represented themselves as a finite state transducer verifying certain assumptions.
https://en.wikipedia.org/wiki?curid=29468
299,194
2,138,983
To date several approaches have been proposed to predict RD values from protein sequences. Yuan and Wang proposed a computational framework that uses sequential evolutionary information contained in PSI-BLAST profiles and the global protein size information to quantify the relationship between RD and protein sequence. Zhang et al. proposed the RDpred method to predict RD values based on predicted secondary structure, residue position and PSI-BLAST profile. More recently, Song et al. described another sequence-based method that also uses support vector regression to quantify the RD-sequence relationship. Their webserver Prodepth, is developed to facilitate RD prediction analysis for sequences submitted by interested users. In addition, Prodepth server can predict the solvent-accessible surface area (ASA) value for each residue for users' submitted sequence. Based on the predicted ASA and RD values, it will further output the two-state solvent accessibility prediction by classifying a residue as being exposed or buried.
https://en.wikipedia.org/wiki?curid=28319584
2,137,753
576,393
The Type 2 was a development of the earlier Type 1 submachine gun, designed in response to criticisms of the Type 1's awkward ergonomics. The Type 2 offered a more conventional magazine feed and stock, but wholly retained the Type 1's method of operation and was essentially the same gun in a different body. It was initially produced in the mid-1930s and was tested by the Imperial Japanese Army, but rejected. During World War II, an urgent demand for automatic infantry weapons saw the revival of several experimental weapon projects, including the Type 2 submachine gun. Blueprints of the weapon was sent to the Mukden Arsenal in Manchukuo in 1944 for use in development of cheap submachine guns. Instead, those blueprints were used by the Chinese communists to produce submachine guns to be used in the Chinese Civil War following the end of the war with Japan and communist control over Mukden. These weapons were operationally identical but chambered in .45 ACP rather than 8×22mm Nambu. The British and US armies studied examples of the earlier Japanese prototypes obtained in Singapore and Japan after the surrender of Japan.
https://en.wikipedia.org/wiki?curid=20671433
576,099
203,735
In the second story, "The Highlanders" (1966–67), Jamie McCrimmon joined the TARDIS crew, and remained with the Second Doctor for the rest of his travels. At the conclusion of "The Faceless Ones" (1967), Ben and Polly left together when the TARDIS landed at Gatwick Airport on the same day they originally left with the First Doctor, after they had stopped the mass kidnapping of tourists by shape shifting aliens. In the following story "The Evil of the Daleks" (1967), the Doctor and Jamie became involved in a plot by the Daleks to gain both the "Human and Dalek Factors" when the TARDIS was stolen, which led to them meeting Victoria Waterfield in the 19th century. The Doctor used the situation to engineer a Dalek civil war that seemingly destroyed the Daleks forever. However, Victoria's father was among the casualties. Now an orphan, Victoria chose to accompany the Doctor and Jamie on their travels. Although she felt great affection for the Doctor and Jamie, she was never able to completely come to terms with life in the TARDIS and the constant danger that resulted. She eventually chose to leave after the events of "Fury from the Deep" (1968) and was adopted by Mr. and Mrs. Harris in the 20th Century. After the events of "The Wheel in Space" (1968), the Doctor and Jamie were then joined by Zoe Heriot, an extremely intelligent woman from the 21st century, who helped defeat the Cybermen attack on a space station known as the Wheel. She then stowed away in the TARDIS and, despite the Doctor's warnings about what she might encounter, chose to remain.
https://en.wikipedia.org/wiki?curid=1980551
203,630
509,206
Preservation also has become an issue with the prevalence of digital distribution on console platforms; as manufacturers drop support for older hardware, games that exist only in digital form may be lost. This issue came to light when Sony Interactive Entertainment announced plans to shut down storefronts for the PlayStation 3, PlayStation Portable and PlayStation Vita by mid-2021, though which Sony later reversed, leaving the PlayStation 3 and Vita stores open indefinitely, while limiting PlayStation Portable purchases to the Vita and PlayStation 3 storefronts. An estimated 2,200 games across these platforms were only available digitally, and while most have versions on other platforms, about 120 were exclusive to the Sony platform and would become completely unavailable after the stores' closure. Prior to reversing their decision, Sony did not provide any immediate plans to offer these titles by other means. Nintendo faced similar concerns when they announced plans to shutter the Nintendo eShop for the Wii U and Nintendo 3DS by March 2023, which would remove around 1,000 digital-only games from availability. While some games available digitally are also offered in a physical retail product, the contents of the physical product may only be a portion of the game or a redemption key for a digital storefront. Additionally, digital games may be reliant on middleware solutions from third parties that may have gone out of business, making it near impossible to recover the full game even if the game developer has full source code available.
https://en.wikipedia.org/wiki?curid=53537897
508,942
573,355
Fast protein liquid chromatography (FPLC), is a form of liquid chromatography that is often used to analyze or purify mixtures of proteins. As in other forms of chromatography, separation is possible because the different components of a mixture have different affinities for two materials, a moving fluid (the mobile phase) and a porous solid (the stationary phase). In FPLC the mobile phase is an aqueous solution, or "buffer". The buffer flow rate is controlled by a positive-displacement pump and is normally kept constant, while the composition of the buffer can be varied by drawing fluids in different proportions from two or more external reservoirs. The stationary phase is a resin composed of beads, usually of cross-linked agarose, packed into a cylindrical glass or plastic column. FPLC resins are available in a wide range of bead sizes and surface ligands depending on the application.
https://en.wikipedia.org/wiki?curid=3865434
573,061
336,073
Fast protein liquid chromatography (FPLC), is a form of liquid chromatography that is often used to analyze or purify mixtures of proteins. As in other forms of chromatography, separation is possible because the different components of a mixture have different affinities for two materials, a moving fluid (the "mobile phase") and a porous solid (the stationary phase). In FPLC the mobile phase is an aqueous solution, or "buffer". The buffer flow rate is controlled by a positive-displacement pump and is normally kept constant, while the composition of the buffer can be varied by drawing fluids in different proportions from two or more external reservoirs. The stationary phase is a resin composed of beads, usually of cross-linked agarose, packed into a cylindrical glass or plastic column. FPLC resins are available in a wide range of bead sizes and surface ligands depending on the application.
https://en.wikipedia.org/wiki?curid=6329
335,895
174,537
RIT's co-op program, which began in 1912, is the fourth-oldest in the world. It is also the fifth-largest in the nation, with approximately 3,500 students completing a co-op each year at over 2,000 businesses. The program requires (or allows, depending on major) students to work in the workplace for up to five quarters alternating with quarters of class. The amount of co-op varies by major, usually between 3 and 5 three-month "blocks" or academic quarters. Many employers prefer students to co-op for two consecutive blocks, referred to as a "double-block co-op". During a co-op, the student is not required to pay tuition to the school and is still considered a "full time" student. In addition, RIT was listed by "U.S. News & World Report" as one of only 12 colleges nationally recognized for excellence in the internships/co-ops category and has secured this ranking, which is based on nominations from college presidents, chief academic officers and deans, for four years in a row since U.S. News began the category in 2002. Additionally, according to the most recent PayScale College Salary Report, the median starting salary for a recent RIT graduate is $51,000 making it among the highest of all Rochester area institutions.
https://en.wikipedia.org/wiki?curid=81756
174,446
815,091
The consequences of scientific fraud vary based on the severity of the fraud, the level of notice it receives, and how long it goes undetected. For cases of fabricated evidence, the consequences can be wide-ranging, with others working to confirm (or refute) the false finding, or with research agendas being distorted to address the fraudulent evidence. The Piltdown Man fraud is a case in point: The significance of the bona-fide fossils that were being found was muted for decades because they disagreed with Piltdown Man and the preconceived notions that those faked fossils supported. In addition, the prominent paleontologist Arthur Smith Woodward spent time at Piltdown each year until he died, trying to find more Piltdown Man remains. The misdirection of resources kept others from taking the real fossils more seriously and delayed the reaching of a correct understanding of human evolution. (The Taung Child, which should have been the death knell for the view that the human brain evolved first, was instead treated very critically because of its disagreement with the Piltdown Man evidence.)
https://en.wikipedia.org/wiki?curid=29537
814,657
724,124
In his job as Head Experimental Brewer at Guinness, the self-trained Gosset developed new statistical methods – both in the brewery and on the farm – now central to the design of experiments, to proper use of significance testing on repeated trials, and to analysis of economic significance (an early instance of decision theory interpretation of statistics) and more, such as his small-sample, stratified, and repeated balanced experiments on barley for proving the best yielding varieties. Gosset acquired that knowledge by study, by trial and error, by cooperating with others, and by spending two terms in 1906–1907 in the Biometrics laboratory of Karl Pearson. Gosset and Pearson had a good relationship. Pearson helped Gosset with the mathematics of his papers, including the 1908 papers, but had little appreciation of their importance. The papers addressed the brewer's concern with small samples; biometricians like Pearson, on the other hand, typically had hundreds of observations and saw no urgency in developing small-sample methods.
https://en.wikipedia.org/wiki?curid=105651
723,744
2,006,430
Cross-linguistic influence can be understood as the various ways that two or more languages relate in the mind and affect a person's linguistic performance or development. Cross-linguistic effects of orthographic and semantic overlap between different languages of cognates and interlingual homographs were also reported in many priming studies. For example, Beauvillain and Grainger had French–English bilinguals make English lexical decisions on target strings primed by French words, which was told to the participants. The homographic primes were French words that were either semantically related to the English words (e.g., "coin": "money" in English, "corner" in French) or not related. The results showed that bilinguals responded faster in related conditions than in unrelated conditions. Even though the participants knew that the prime words always associated with their French meaning, they were still affected by the English meaning of the homographic prime words. In later studies, researchers masked the briefly presented prime words to prevent participants from using conscious strategies. For instance, Sáchez-Casas et al. used Spanish–English bilinguals in a semantic categorization task on Spanish target words. They used three types of priming conditions: entirely identical cognates or non-cognates (rico-rico; pato-pato), translations of cognates or non-cognates (rich-rico; duck-pato) and non-word primes combined with cognate or non-cognate targets as a control condition (rict-rico vs. wuck-pato). They found that bilinguals responded to the cognate translation conditions as fast as the identical conditions, but the non-cognate translation was as slow as the control conditions.
https://en.wikipedia.org/wiki?curid=39178155
2,005,281
1,292,603
With a $70.5 million expansion plan, more than of space will be built over the course of five years beginning in 2017. This will allow for the growth of hundreds of staff positions and 100 physicians. The expansion will provide: space for cardiovascular, radiology and cardio-thoracic surgery program areas, expansion of the spine center and pain rehabilitation programs, additional surgical rooms, space and equipment to establish a molecular imaging center for radiology and laboratory expansion. Four new floors will be added to the Mayo-South Building and in the Davis Building will be remodeled. Three additional buildings will be constructed; one will provide integrated services of complex cancers and have space for neurologic and neurosurgical care, one will be a lung restoration center to allow for more transplantations, and the third will include a positron emission tomography (PET) radiochemistry facility with an on-site cyclotron.
https://en.wikipedia.org/wiki?curid=21466606
1,291,892
346,115
As the speed of an object increases, so does the drag force acting on it, which also depends on the substance it is passing through (for example air or water). At some speed, the drag or force of resistance will equal the gravitational pull on the object (buoyancy is considered below). At this point the object stops accelerating and continues falling at a constant speed called the terminal velocity (also called settling velocity). An object moving downward faster than the terminal velocity (for example because it was thrown downwards, it fell from a thinner part of the atmosphere, or it changed shape) will slow down until it reaches the terminal velocity. Drag depends on the projected area, here represented by the object's cross-section or silhouette in a horizontal plane. An object with a large projected area relative to its mass, such as a parachute, has a lower terminal velocity than one with a small projected area relative to its mass, such as a dart. In general, for the same shape and material, the terminal velocity of an object increases with size. This is because the downward force (weight) is proportional to the cube of the linear dimension, but the air resistance is approximately proportional to the cross-section area which increases only as the square of the linear dimension. For very small objects such as dust and mist, the terminal velocity is easily overcome by convection currents which prevent them from reaching the ground and hence they stay suspended in the air for indefinite periods. Air pollution and fog are examples of convection currents.
https://en.wikipedia.org/wiki?curid=256662
345,934
1,014,352
The original 40-year operating licenses for Units 2 and 3 expired in September 2013 and December 2015, respectively. Entergy had applied for license extensions and the Nuclear Regulatory Commission (NRC) was moving toward granting a twenty-year extension for each reactor. However, due to a number of factors including sustained low wholesale energy prices that reduced revenues, as well as pressure from local environmental groups and then-Governor of New York Andrew Cuomo, it was announced that the plant would shut down by 2021. The plant permanently stopped generating energy on April 30, 2021. About 1,000 employees lost their jobs as a result of the shutdown.
https://en.wikipedia.org/wiki?curid=1632712
1,013,831
1,973,318
In 1967, he graduated the first class of physician assistant students from Duke University's PA program. He interned in internal medicine and surgery at the Peter Bent Brigham Hospital in Boston, Massachusetts and also at Cincinnati General Hospital and Boston City Hospital. His educational philosophy placed emphasis on knowing how to look up information for "just in time" delivery rather than memorizing volumes of information only to forget it before needed. The niche that he envisioned for PAs was that most health care encounters do not require extensive training and that superior medical care can be delivered by relieving the burden of mundane medical encounters by training PA professionals to know when to seek additional input. He wanted all PAs to be required to have mentoring relationships with Physicians to ensure access to a larger body of medical knowledge.
https://en.wikipedia.org/wiki?curid=2847162
1,972,183