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Bush's method of management at the OSRD was to direct overall policy, while delegating supervision of divisions to qualified colleagues and letting them do their jobs without interference. He attempted to interpret the mandate of the OSRD as narrowly as possible to avoid overtaxing his office and to prevent duplicating the efforts of other agencies. Bush would often ask: "Will it help to win a war; "this" war?" Other challenges involved obtaining adequate funds from the president and Congress and determining apportionment of research among government, academic, and industrial facilities. His most difficult problems, and also greatest successes, were keeping the confidence of the military, which distrusted the ability of civilians to observe security regulations and devise practical solutions, and opposing conscription of young scientists into the armed forces. This became especially difficult as the army's manpower crisis really began to bite in 1944. In all, the OSRD requested deferments for some 9,725 employees of OSRD contractors, of which all but 63 were granted. In his obituary, "The New York Times" described Bush as "a master craftsman at steering around obstacles, whether they were technical or political or bull-headed generals and admirals."
https://en.wikipedia.org/wiki?curid=32767
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Surprisingly, gauge symmetry can give a deeper explanation for the existence of interactions, such as the electric and nuclear interactions. This arises from a type of gauge symmetry relating to the fact that all particles of a given type are experimentally indistinguishable from one another. Imagine that Alice and Betty are identical twins, labeled at birth by bracelets reading A and B. Because the girls are identical, nobody would be able to tell if they had been switched at birth; the labels A and B are arbitrary, and can be interchanged. Such a permanent interchanging of their identities is like a global gauge symmetry. There is also a corresponding local gauge symmetry, which describes the fact that from one moment to the next, Alice and Betty could swap roles while nobody was looking, and nobody would be able to tell. If we observe that Mom's favorite vase is broken, we can only infer that the blame belongs to one twin or the other, but we cannot tell whether the blame is 100% Alice's and 0% Betty's, or vice versa. If Alice and Betty are in fact quantum-mechanical particles rather than people, then they also have wave properties, including the property of superposition, which allows waves to be added, subtracted, and mixed arbitrarily. It follows that we are not even restricted to complete swaps of identity. For example, if we observe that a certain amount of energy exists in a certain location in space, there is no experiment that can tell us whether that energy is 100% A's and 0% B's, 0% A's and 100% B's, or 20% A's and 80% B's, or some other mixture. The fact that the symmetry is local means that we cannot even count on these proportions to remain fixed as the particles propagate through space. The details of how this is represented mathematically depend on technical issues relating to the spins of the particles, but for our present purposes we consider a spinless particle, for which it turns out that the mixing can be specified by some arbitrary choice of gauge θ("x"), where an angle θ = 0° represents 100% A and 0% B, θ = 90° means 0% A and 100% B, and intermediate angles represent mixtures.
https://en.wikipedia.org/wiki?curid=291912
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Clinical course tends to be more severe than with Kawasaki disease. A child's condition can deteriorate rapidly, even in the presence of reassuring laboratory findings. Many children develop shock and heart failure. Most require paediatric intensive care. Supplemental oxygen is often needed, and mechanical ventilation is sometimes used. Most children who receive expert multidisciplinary care survive. In addition to respiratory distress, major complications that may need aggressive supportive care can include myocardial damage, acute kidney injury, and coagulopathy (thrombophilia). In some cases, sustained cardiac arrhythmias have led to haemodynamic collapse and need for extracorporeal membrane oxygenation (ECMO). Deaths have been recorded in a small minority (under 2%) of the cases reported. Occasionally, fatalities have followed complications of ECMO. Some children exposed to COVID-19 also appear to have a less severe Kawasaki-like disease. Ventricular function often recovers before discharge from hospital (often after 6–10 days). Coronary artery aneurysms can develop even in the absence of Kawasaki-like features. Their frequency and severity is uncertain. So far, they have been recorded in 7% of reported cases. Long-term prognosis is unclear.
https://en.wikipedia.org/wiki?curid=63895130
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There are currently 27 fraternities in the Interfraternity Council, 14 sororities in the Panhellenic Council, 14 fraternities and sororities in the United Greek Association, and 10 fraternities and sororities in the National Panhellenic Council at Washington State University. There are 26 primarily residential fraternities and 14 primary residential sororities that are located on College Hill. Kappa Sigma is the oldest national fraternity at WSU with a founding date in 1909 and Alpha Delta Pi was the first sorority at WSU with a founding date in 1912. The average chapter size of the community organizations is 64 members. Between 25-30 percent of undergraduate students are in the Greek community annually. Greek affiliates have the highest GPA on WSU's campus, averaging 3.2 for sorority women and 2.97 for fraternity men based on figures from Spring 2018. Individuals join chapters by going through recruitment, often a week at the beginning of one or both semesters where chapter members hold events to meet potential new members. Washington State University has a zero tolerance policy on hazing both potential new members and current members. Each year Greek chapters submit 6 Pillars of Excellence, each pillar representing a value of Greek Life at WSU, and do reports at the end of the year as a self-evaluation for each chapter. Washington State University "recognizes the right of each fraternity and sorority to create policies and regulations of internal governance, as long as said policies do not conflict with those described in this document or any of its appendices."
https://en.wikipedia.org/wiki?curid=228600
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The Schuman lab studies the properties of mRNAs and proteins (e.g. the transcriptomes and proteomes) distributed throughout the neuron. Her research has examined how stability in neuronal processes can be brought about by local cell biological processes, like protein synthesis, allowing synapses to respond rapidly and appropriately to changing stimuli. The Schuman lab demonstrated the first functional role for local translation in neurons. In 1996, in the course of exploring how neurotrophins enhance synaptic transmission, Schuman together with graduate student Hyejin Kang made the discovery that local protein synthesis within dendrites is required for this form of synaptic plasticity. She obtained direct proof that protein synthesis occurs in intact, isolated dendrites. This, together with a few other key observations, gave birth to the field of local translation. Her team discovered, using next generation sequencing, over 2500 mRNAs localized to the neuropil. In addition, Schuman and collaborators (Dave Tirrell, Caltech and Daniela Dieterich, Magdeburg) has made invaluable technical contributions, such as the development of non-canonical amino acid metabolic labelling, click chemistry, and mutation of cell-biological enzymes (the BONCAT and FUNCAT techniques), enabling the labelling, purification, identification and visualization of newly synthesized proteins in neurons and other cells.
https://en.wikipedia.org/wiki?curid=58886407
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The origins of the Skylark can be traced back decisions made in the aftermath of the Second World War. Unlike some powers, the United Kingdom had not opted to immediately proceed with work on long-range rocketry; however, the Ministry of Supply did work on defensive guided weaponry, leading to the arrival of surface-to-air missiles such as the Bloodhound during the 1950s. To conduct these programmes, the ministry developed a series of test missiles for research and development. During May 1953, amid the preparations for a major conference in Oxford on rocket-based exploration of the upper atmosphere, the Ministry of Supply approached the "Gassiot Committee" of the Royal Society with an offer of using ministry rockets for scientific research. This offer, while positively received, was quickly realised to far exceed what would be affordable to the universities. During February 1954, a group of scientists enthusiastically responded to a closed briefing on a Royal Aircraft Establishment (RAE) project, the "CTV.5 Series 3" rocket (which would later adopt the name "Skylark"). The CTV series of rockets had originally been used to investigate aerodynamic control of missiles, yet the Skylark was stated to be capable of carrying a payload of 100 lb to an altitude of 200 km (124 mi).
https://en.wikipedia.org/wiki?curid=1414851
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LiFePO is a 3.6 V lithium-ion battery cathode initially reported by John Goodenough and is structurally related to the mineral olivine and consists of a three dimensional lattice of an [FePO4] framework surrounding a lithium cation. The lithium cation sits in a one dimensional channel along the [010] axis of the crystal structure. This alignment yields anisotropic ionic conductivity that has implications for its usage as a battery cathode and makes morphological control an important variable in its electrochemical cell rate performance. Although the iron analogue is the most commercial owing to its stability, the same composition exists for nickel, manganese, and cobalt although the observed high cell charging voltages and synthetic challenges for these materials make them viable but more difficult to commercialize. While the material has good ionic conductivity it possesses poor intrinsic electronic conductivity. This combination makes nanophase compositions and composites or coatings (to increase electronic conductivity of the whole matrix) with materials such as carbon advantageous. Alternatives to nanoparticles include mesoscale structure such as nanoball batteries of the olivine LiFePO that can have rate capabilities two orders of magnitude higher than randomly ordered materials. The rapid charging is related to the nanoballs high surface area where electrons are transmitted to the surface of the cathode at a higher rate.
https://en.wikipedia.org/wiki?curid=42601555
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The Garnaut Climate Change Review notes many barriers to increased global biosequestration. "There must be changes in the accounting regimes for greenhouse gases. Investments are required in research, development and commercialisation of superior approaches to biosequestration. Adjustments are required in the regulation of land use. New institutions will need to be developed to coordinate the interests in utilisation of biosequestration opportunities across small business in rural communities. Special efforts will be required to unlock potential in rural communities in developing countries." Saddler and King have argued that biosequestration and agricultural greenhouse gas emissions should not be handled within a global emissions trading scheme because of difficulties with measuring such emissions, problems in controlling them and the burden that would be placed on numerous small-scale farming operations. Collett likewise maintains that REDD credits (post-facto payments to developing countries for reducing their deforestation rates below an historical or projected reference rate), simply create a complex market approach to this global public health problem that reduces transparency and accountability when targets are not met and will not be as effective as developed nations voluntarily funding countries to keep their rainforests.
https://en.wikipedia.org/wiki?curid=24603722
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Pitt-Greensburg opened in September 1963, following a request of area school superintendents for a branch campus of the University of Pittsburgh. Pitt-Greensburg began as a two-year institution with instruction in nine areas of study, 15 faculty, 56 full-time, and 156 part-time students. The school was originally located in the Vogle Building, a former private elementary school and Greensburg School System administrative building located at 122 North Maple Avenue in downtown Greensburg across from St. Clair Park. Fine arts classes were originally taught at the Westmoreland Museum of American Art, physical education was held at the Greensburg YMCA, and laboratory classes were held in what is now Greensburg Salem Middle School. In 1964, the university purchased the Charles McKenna Lynch estate in Hempfield. At first, faculty offices and classrooms were split between Greensburg and Lynch Hall, a former residence on the Lynch estate campus. In 1976, the entire Pitt-Greensburg campus moved to the Hempfield location on the former Lynch estate. Until 1988, when it received 4-year degree-granting status, Pitt-Greensburg served as a two-year feeder school to the main campus as the University of Pittsburgh in the Oakland section of Pittsburgh. By 1989, Pitt-Greensburg had its first graduating class. In 1999, a distinctive feature of Pitt-Greensburg opened when the first of three Academic Villages (Behavioral Sciences, Natural Sciences, and Humanities), where high-achieving students live in residences based on their majors and participate in after-class events geared to those disciplines. As (2018), the campus boasts 29 majors, 24 minors, and four certificate programs.
https://en.wikipedia.org/wiki?curid=3202822
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The x-axis of a Tanabe–Sugano diagram is expressed in terms of the ligand field splitting parameter, Δ, or "Dq" (for "differential of quanta"), divided by the Racah parameter B. The y-axis is in terms of energy, E, also scaled by B. Three Racah parameters exist, A, B, and C, which describe various aspects of interelectronic repulsion. "A" is an average total interelectron repulsion. "B" and "C" correspond with individual d-electron repulsions. "A" is constant among d-electron configuration, and it is not necessary for calculating relative energies, hence its absence from Tanabe and Sugano's studies of complex ions. "C" is necessary only in certain cases. "B" is the most important of Racah's parameters in this case. One line corresponds to each electronic state. The bending of certain lines is due to the mixing of terms with the same symmetry. Although electronic transitions are only "allowed" if the spin multiplicity remains the same (i.e. electrons do not change from spin up to spin down or vice versa when moving from one energy level to another), energy levels for "spin-forbidden" electronic states are included in the diagrams, which are also not included in Orgel diagrams. Each state is given its molecular-symmetry label (e.g. A, T, etc.), but "g" and "u" subscripts are usually left off because it is understood that all the states are "gerade". Labels for each state are usually written on the right side of the table, though for more complicated diagrams (e.g. d) labels may be written in other locations for clarity. Term symbols (e.g. P, S, etc.) for a specific d free ion are listed, in order of increasing energy, on the y-axis of the diagram. The relative order of energies is determined using Hund's rules. For an octahedral complex, the spherical, free ion term symbols split accordingly:
https://en.wikipedia.org/wiki?curid=5248484
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Work at Ball Research brought Widlar in contact with Jean Hoerni and Sheldon Roberts, the creators of radiation hardened transistors and co-founders of Fairchild Semiconductor. Widlar decided to move to a semiconductor manufacturing company, and in 1963 Jerry Sanders, a Fairchild Semiconductor salesman, provided him the opportunity. According to Thomas Lee, Fairchild also wanted to have Widlar on board, and breached professional ethics by recruiting a key employee of their customer. In September 1963 Widlar was invited for an interview with Fairchild research and development (R&D) manager Heinz Ruegg. Widlar arrived at the interview intoxicated, and frankly told Ruegg what he thought about Fairchild's analog circuits: "What they are doing is bullshit". Widlar was sent to another interview with the company's Applications Engineering division, which was based in Mountain View, California. The division head, John Hulme, hired Widlar despite objections from the first round interviewers. Widlar's first assignment at Fairchild targeted IC reliability through adjustments in fabrication processes. This early work, directed by process engineer David Talbert, reduced the cost of the planar process and made possible development of monolithic (fully integrated) linear ICs. Widlar, who formally reported to John Barrett, proved himself capable of quickly improving Barrett's own designs and very soon squeezed his nominal boss out of the company.
https://en.wikipedia.org/wiki?curid=3483624
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Former St Andrews students active in politics and national intelligence include two Chiefs of MI6 Alex Younger and John Sawers, two deputy directors of the Secret Intelligence Service (MI6), George Kennedy Young and J. M. Bruce Lockhart, Secretary of State for Scotland Lord Forsyth (Forsyth is also former deputy chairman of JP Morgan), former First Minister of Scotland and leader of the SNP for over 20 years Alex Salmond, former Cabinet Secretary and head of the Civil Service Sir Mark Sedwill, former Secretary of State for Defence Sir Michael Fallon, Deputy Leader of the Liberal Democrats Malcolm Bruce and leader of the Christian Party James George Hargreaves. Outside of the UK, alumni include the financial secretary of Hong Kong credited with laying the foundations for Hong Kong's economic success John James Cowperthwaite, former senior director for European and Russian affairs on the United States National Security Council, Fiona Hill, David Holmes (both were involved in the Impeachment inquiry against Donald Trump), and the first female cabinet minister in Egypt Hikmat Abu Zayd. Alumni have also gone on to serve as diplomats including the current Permanent Representative of the United Kingdom to the United Nations and former British Ambassador to China (2015–2020) Dame Barbara Woodward, former ambassador to Russia (2008–2011) Dame Anne Pringle and Thomas Bruce who is known for the removal of the Elgin Marbles from the Parthenon.
https://en.wikipedia.org/wiki?curid=181348
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Richter was born in Overpeck, Ohio. Richter had German heritage: his great-grandfather was a Forty-Eighter, coming from Baden-Baden (today in Baden-Württemberg, Germany) in 1848 in the wake of the Revolutions of 1848 in the German states. Richter's parents Frederick William and Lillian Anna (Kinsinger) Richter, were divorced when he was very young. He grew up with his maternal grandfather, who moved the family (including his mother) to Los Angeles in 1909. After graduating from Los Angeles High School he attended Stanford University and received his undergraduate degree in 1920. In 1928, he began work on his PhD in theoretical physics from the California Institute of Technology, but, before he finished it, he was offered a position at the Carnegie Institute of Washington. At this point, he became fascinated with seismology (the study of earthquakes and the waves they produce in the earth). Thereafter, he worked at the new Seismological Laboratory in Pasadena, under the direction of Beno Gutenberg. In 1932, Richter and Gutenberg developed a standard scale to measure the relative sizes of earthquake sources, called the Richter scale. In 1937, he returned to the California Institute of Technology, where he spent the rest of his career, eventually becoming professor of seismology in 1952.
https://en.wikipedia.org/wiki?curid=230732
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Vernon W. Hughes "et al." (1960) and Ronald Drever (1961) independently conducted similar spectroscopic experiments to test Mach's principle. However, they didn't use the Mössbauer effect but made magnetic resonance measurements of the nucleus of lithium-7, whose ground state possesses a spin of . The ground state is split into four equally spaced magnetic energy levels when measured in a magnetic field in accordance with its allowed magnetic quantum number. The nuclear wave functions for the different energy levels have different spatial distributions relative to the magnetic field, and thus have different directional properties. If mass isotropy is satisfied, each transition between a pair of adjacent levels should emit a photon of equal frequency, resulting in a single, sharp spectral line. On the other hand, if inertia has a directional dependence, a triplet or broadened resonance line should be observed. During the 24-hour course of Drever's version of the experiment, the Earth turned, and the magnetic field axis swept different sections of the sky. Drever paid particular attention to the behavior of the spectral line as the magnetic field crossed the center of the galaxy. Neither Hughes nor Drever observed any frequency shift of the energy levels, and due to their experiments' high precision, the maximal anisotropy could be limited to 0.04 Hz = 10 GeV.
https://en.wikipedia.org/wiki?curid=31892050
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Formula 1 returned to Japan for the first time in 10 years and the circus came for the first time to the twisty, very demanding Honda-owned Suzuka track near Nagoya having been at the very fast Fuji Speedway in 1977. An exciting World Championship showdown between Williams-Honda teammates Nelson Piquet and Nigel Mansell was on the cards, Piquet was 12 points ahead of Mansell. During qualifying Mansell crashed heavily at the fast Snake sweepers behind the paddock, the accident left him with severe bruising to his backbone, re-triggering an old injury and it was decided that he should not be allowed to race. Having spent Friday night in hospital Mansell flew back to Europe on Saturday evening. Nelson Piquet was World Champion for the third time, his season-long consistency having paid dividends. The entry was much as it had been in Mexico although AGS decided to replace Pascal Fabre with Roberto Moreno. Gerhard Berger took pole position in his Ferrari ahead of Alain Prost's McLaren, Thierry Boutsen's Benetton-Ford and Michele Alboreto in the second Ferrari. Then came Piquet and Teo Fabi (Benetton) with the top 10 completed by Ayrton Senna (Lotus), Riccardo Patrese (Brabham-BMW), Stefan Johansson's McLaren and the second Brabham of Andrea de Cesaris. In the race Berger took the lead at the start and was never threatened, winning a dominant victory; this was Ferrari's first victory since the 1985 German Grand Prix. Boutsen chased Berger early on but dropped behind Senna, Piquet and Johansson. Piquet's race ended with an engine failure in the closing laps, so fourth place went to Alboreto with Boutsen fifth and Satoru Nakajima sixth.
https://en.wikipedia.org/wiki?curid=1139093
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Basri graduated in physics at Stanford University in 1973, and received his Ph.D. in astrophysics at the University of Colorado in 1979. His thesis, under the supervision of Jeffrey Linsky, was on radiative transfer theory and stellar activity. It was partially based on observations by the International Ultraviolet Explorer (IUE) satellite, of which Linsky's group was one of the first users. A postdoctoral award took him to the U.C. Berkeley astronomy department in 1979. In 1982 he joined the faculty of the Astronomy Department where he has been ever since, becoming a full professor in 1994 and formally retiring in 2015 (though he remains active). GB was awarded a Miller Research Professorship in 1997, and became a Sigma Xi Distinguished Lecturer in 2000. He held a NASA Faculty Fellowship in 2002 and became a Fellow of the California Academy of Science in 2011. Awards from the Berkeley campus include the Chancellor's Award for Increasing Institutional Excellence in 2005 and the Berkeley Citation (highest honor) in 2015. He was the recipient of the Carl Sagan Prize for Science Popularization in 2016.
https://en.wikipedia.org/wiki?curid=33833023
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Justice was administered free of charge, by special officers appointed as judges and magistrates, but the king was supreme and the final arbiter in all civil and criminal cases. Mortgage, lease, trust property, loans, breach of contract were some common sources of civil litigation, while criminal offences included theft, adultery, forgery and treason. The punishments were very severe and hence crimes were rare: one caught in the act of burglary, adultery or spying was given the death penalty and one giving false testimony would have his tongue cut off. The king was the chief commander of the army and usually led his army in the battlefield. The military was said to be fourfold : the infantry, the cavalry, the elephantry and the chariotry. A wide variety of war weapons filled the military arsenal including shields, swords, spears, tridents, maces, bows and arrows. The main sources of royal revenue were taxes, tributes, customs duties and tolls. Land tax, paid in money or in kind, and income tax, equal to one-sixth of an individual's income, were the major types of taxes collected. Other sources of revenue include tributes paid by feudal subordinates, war booty presents by loyal and visiting subjects, treasure troves besides land revenue, cess and forced gifts. The items incurring expenditure for the king include the military, gifts to poets and temples, maintenance of educational and health services, building infrastructure such as roads and irrigation and the palace household expenses.
https://en.wikipedia.org/wiki?curid=11673386
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A microarray is a multiplex lab-on-a-chip. Its purpose is to simultaneously detect the expression of thousands of genes from a sample (e.g. from a tissue). It is a two-dimensional array on a solid substrate—usually a glass slide or silicon thin-film cell—that assays (tests) large amounts of biological material using high-throughput screening miniaturized, multiplexed and parallel processing and detection methods. The concept and methodology of microarrays was first introduced and illustrated in antibody microarrays (also referred to as antibody matrix) by Tse Wen Chang in 1983 in a scientific publication and a series of patents. The "gene chip" industry started to grow significantly after the 1995 "Science Magazine" article by the Ron Davis and Pat Brown labs at Stanford University. With the establishment of companies, such as Affymetrix, Agilent, Applied Microarrays, Arrayjet, Illumina, and others, the technology of DNA microarrays has become the most sophisticated and the most widely used, while the use of protein, peptide and carbohydrate microarrays is expanding.
https://en.wikipedia.org/wiki?curid=167570
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The AN/MPQ-64 Sentinel is a three-dimensional radar used to alert and queue Short Range Air Defense (SHORAD) weapons to the locations of hostile targets approaching their front line forces. The Sentinel radar is deployed with forward area air defense units of the U.S. Army and USMC. The radar uses an X-band range-gated, pulse-doppler system. The antenna uses phase-frequency electronic scanning technology, forming sharp 3D pencil beams covering large surveillance and track volume. The radar automatically acquires, tracks, classifies, identifies and reports targets, including cruise missiles, unmanned aerial vehicles, rotary and fixed-wing aircraft. It uses a high scan rate (30 RPM) and operates at a range of 40 km. The radar is designed with high resistance to electronic countermeasures (ECM). Mounted on a towed platform, it can be positioned remotely from the rest of the unit, operated autonomously and communicate with the Fire Distribution Center (FDC) via wideband fiber-optic link. It can also distribute its data over a SINCGARS radio network.
https://en.wikipedia.org/wiki?curid=23200607
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Georgia Tech teams are variously known as the Yellow Jackets, the Ramblin' Wreck and the Engineers; but the official nickname is "Yellow Jackets". They compete as a member of the National Collegiate Athletic Association (NCAA) Division I level (Football Bowl Subdivision (FBS) sub-level for football), primarily competing in the Atlantic Coast Conference (ACC) for all sports since the 1979–80 season (a year after they officially joined the conference before beginning conference play), Coastal Division in any sports split into a divisional format since the 2005–06 season. The Yellow Jackets previously competed as a charter member of the Metro Conference from 1975–76 to 1977–78, as a charter member of the Southeastern Conference (SEC) from 1932–33 to 1963–64, as a charter of the Southern Conference (SoCon) from 1921–22 to 1931–32, and as a charter member of the Southern Intercollegiate Athletic Association (SIAA) from 1895–96 to 1920–21. They also competed as an Independent from 1964–65 to 1974–75 and on the 1978–79 season. Men's sports include baseball, basketball, cross country, football, golf, swimming & diving, cheerleading, tennis and track & field; while women's sports include basketball, cross country, softball, swimming and diving, tennis, track & field, cheerleading, and volleyball. Their cheerleading squad has, in the past, only competed the National Cheerleaders & Dance Association (NCA & NDA) College Nationals along with Buzz and the Goldrush dance team competing here as well. However, in the 2022 season, Goldrush competed at the Universal Cheerleaders & Dance Association (UCA & UDA) College Nationals for the first time and in 2023 the cheer team will compete here for the first time as well.
https://en.wikipedia.org/wiki?curid=28486339
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It is commonly accepted that the first mathematical reference to splines is the 1946 paper by Schoenberg, which is probably the first place that the word "spline" is used in connection with smooth, piecewise polynomial approximation. However, the ideas have their roots in the aircraft and shipbuilding industries. In the foreword to (Bartels et al., 1987), Robin Forrest describes "lofting", a technique used in the British aircraft industry during World War II to construct templates for airplanes by passing thin wooden strips (called "splines") through points laid out on the floor of a large design loft, a technique borrowed from ship-hull design. For years the practice of ship design had employed models to design in the small. The successful design was then plotted on graph paper and the key points of the plot were re-plotted on larger graph paper to full size. The thin wooden strips provided an interpolation of the key points into smooth curves. The strips would be held in place at discrete points (called "ducks" by Forrest; Schoenberg used "dogs" or "rats") and between these points would assume shapes of minimum strain energy. According to Forrest, one possible impetus for a mathematical model for this process was the potential loss of the critical design components for an entire aircraft should the loft be hit by an enemy bomb. This gave rise to "conic lofting", which used conic sections to model the position of the curve between the ducks. Conic lofting was replaced by what we would call splines in the early 1960s based on work by J. C. Ferguson at Boeing and (somewhat later) by M.A. Sabin at British Aircraft Corporation.
https://en.wikipedia.org/wiki?curid=457680
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Symbolics ended up producing around 100 LM-2s, each of which sold for $70,000. Both companies developed second-generation products based on the CADR: the Symbolics 3600 and the LMI-LAMBDA (of which LMI managed to sell around 200). The 3600, which shipped a year late, expanded on the CADR by widening the machine word to 36-bits, expanding the address space to 28-bits, and adding hardware to accelerate certain common functions that were implemented in microcode on the CADR. The LMI-LAMBDA, which came out a year after the 3600, in 1983, was mostly upward compatible with the CADR (source CADR microcode fragments could be reassembled), but there were improvements in instruction fetch and other hardware differences including use of a multiplier chip and a faster logic family and cache memory. The LAMBDA's processor cards were designed to work in a NuBus based engineering workstation, which had been originated by Steve Ward's group at MIT, and, through a separate chain of events, was being developed by Western Digital Corporation. This allowed the popular LAMBDA "2x2" configuration whereby two machines shared one infrastructure, with considerable savings. Texas Instruments (TI) joined the fray by investing in LMI after it ran out of money, purchasing and relocating the NUBUS engineering workstation unit from Western Digital, licensing the LMI-LAMBDA design and later producing its own variant, the TI Explorer.
https://en.wikipedia.org/wiki?curid=1084355
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Ernest O. Holland succeeded Enoch Bryan as President of the Washington State College in 1915. That same year, a close friend of his whom he shared a room with while studying at Columbia University, Henry Suzzallo, became the President of the University of Washington. Holland's early years as president and friendship with Suzzallo were challenged during his tenure as president. In 1909, the institutional rivalry between WSC and UW worsened when state legislators, the majority of which held seats in western Washington, were dismayed to find a foreign language department, an English Department headed by a Harvard-educated PhD, a school of architecture, and many departments with graduate students. The legislative committee promptly advised demoting the college to “trade school” status, an idea which Suzzallo supported. Suzzallo penned a letter to Holland promising to make WSC “the greatest school of agriculture in the world” only if Holland agreed to abandon all other disciplines to UW; Suzzallo's proposal specifically sought to shut down WSC's schools of architecture and pharmacy. After years of wrangling, the Washington legislature decided against limiting the academic mission and scope of WSC. The two presidents and their respective institutions continued to have a row over curriculum and state appropriations until Suzzallo was relieved of his position in 1926 due to the influence of Washington governor, Roland H. Hartley. In trying to outdo his former peer at UW, Holland wanted to build a library that rivaled the grandness of the newly built library at UW that bears Suzzallo's name. Funding for the Holland Library was delayed by the state however until 1950.
https://en.wikipedia.org/wiki?curid=228600
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Bioelectric modulation has shown control over complex morphogenesis and remodeling, not merely setting individual cell identity. Moreover, a number of the key results in this field have shown that bioelectric circuits are non-local – regions of the body make decisions based on bioelectric events at a considerable distance. Such non-cell-autonomous events suggest distributed network models of bioelectric control; new computational and conceptual paradigms may need to be developed to understand spatial information processing in bioelectrically-active tissues. It has been suggested that results from the fields of primitive cognition and unconventional computation are relevant to the program of cracking the bioelectric code. Finally, efforts in biomedicine and bioengineering are developing applications such as wearable bioreactors for delivering voltage-modifying reagents to wound sites, and ion channel-modifying drugs (a kind of electroceutical) for repair of birth defects and regenerative repair. Synthetic biologists are likewise starting to incorporate bioelectric circuits into hybrid constructs.
https://en.wikipedia.org/wiki?curid=55498066
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In early 2005, the World Health Organization (WHO) began investigating an outbreak of viral hemorrhagic fever in Angola, which was centered in the northeastern Uíge Province but also affected many other provinces. The Angolan government had to ask for international assistance, pointing out that there were only approximately 1,200 doctors in the entire country, with some provinces having as few as two. Health care workers also complained about a shortage of personal protective equipment such as gloves, gowns, and masks. Médecins Sans Frontières (MSF) reported that when their team arrived at the provincial hospital at the center of the outbreak, they found it operating without water and electricity. Contact tracing was complicated by the fact that the country's roads and other infrastructure were devastated after nearly three decades of civil war and the countryside remained littered with land mines. Americo Boa Vida Hospital in the Angolan capital Luanda set up a special isolation ward to treat infected people from the countryside. Unfortunately, because MVD often results in death, some people came to view hospitals and medical workers with suspicion and treated helpers with hostility. For instance, a specially-equipped isolation ward at the provincial hospital in Uíge was reported to be empty during much of the epidemic, even though the facility was at the center of the outbreak. WHO was forced to implement what it described as a "harm reduction strategy", which entailed distributing disinfectants to affected families who refused hospital care. Of the 252 people who contracted MVD during outbreak, 227 died.
https://en.wikipedia.org/wiki?curid=58743
887,411
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The first of the "flying" IAe 33 prototypes, (No. 02) built in 1950, completed its maiden flight on 27 June of that year, with Captain Edmundo Weiss at the controls. On the second flight, ex-Focke-Wulf test pilot Otto Behrens encountered severe lateral stability problems at speeds over and returned to the airfield as a precaution. Landing at very high speed, the aircraft bounced with sufficient force to cause the right main undercarriage strut to fail. During repairs to the aircraft, in order to rectify the "tricky" landing characteristics, the front undercarriage strut was increased in length, which served to alter the angle of incidence of the aircraft, while the shock absorbers were adjusted to have a greater "throw". Although never considered docile, the modifications improved the takeoff, landing and low-speed characteristics of the IAe 33. More serious aerodynamic problems persisted, stemming from tip stall— in which the wingtip stalled before the wingroot resulting in an unpredictable "rolling moment"— leading to a change in the wing leading edge near the wingroot, while the rudder was modified in an attempt to resolve the interminable lateral instability issues. In addition, the canopy was reinforced with two external frames and a small fairing was installed above the engine exhaust.
https://en.wikipedia.org/wiki?curid=2616710
680,894
104,156
In April 2012, BAE unveiled a potential version of the system mount, developed in collaboration with Rafael Advanced Defense Systems. It is visually distinctive from previous versions with its stealthy housing, which also protects the gun from weather and allows for easier access to internal components through large access panels. The upgrade mounts a larger Alliant Techsystems Mk44 Bushmaster II 30 mm cannon for a 500-meter range increase, as well as a coaxial .50 caliber M2 heavy machine gun. Elevation is increased to +75 degrees for engaging UAVs and helicopters, and ammunition storage is greater at 420 30 mm rounds. Other features include a larger manual fire control panel, an offset mode specifically for firing warning shots, and a surveillance mode where the gun can be pointed away from a target but the EO sensor remains pointed in the target direction. Although it has a high degree of commonality and has the same footprint as previous models, the upgrade is 20 percent heavier due to greater ammo load.
https://en.wikipedia.org/wiki?curid=1561727
104,111
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Other predators long known to have taken tawny owls have included their larger cousins, the Ural owls as well as common buzzards ("Buteo buteo"), red kites ("Milvus milvus") and peregrine falcons ("Falco peregrinus"). In addition, more reported raptorial predators have included the Bonelli's eagle ("Aquila fasciata"), golden eagle ("Aquila chrysaetos"), eastern imperial eagle ("Aquila heliaca") and black kite ("Milvus migrans") Outside of traditionally raptorial groups, birds such as corvids may destroy and/or compromise tawny owl nests, either for food, anti-predator behaviour and/or competition. Western jackdaws, in particular, appear to be persistent competitors for nest sites and sometimes are aggressive enough as to displace tawny owls from a disputed site. In extreme cases of competition with jackdaws, the owls may bring themselves to starvation trying to incubate their nests in the hole when a murder of jackdaws continuously visit, harass and place a new nest on top of the owl's eggs repeatedly. In other cases, the owls nestlings have been suffocated by the jackdaws building a nest directly on top of the still living owl broods. Mammalian predators are a fairly frequent threat to tawny owls as well, though tend to attack almost exclusively during the breeding season. European pine martens are known to be a considerable threat of all aged tawny owls at nests from nestlings to brooding females, as are probably stone martens ("Martes foina"). In a food study in France, 9% of the diet of pine martens was found to consist of tawny owls, with the data indicating that owls using nest boxes are more vulnerable to martens. Especially once reaching or around the age of fledging, red foxes ("Vulpes vulpes") are known to take several young tawny owls (and perhaps an unwary adult), at times taking up to 39% of young owls in a population, as are probably cats ("Felis silvestris") in some areas. However, in chance encounters during the day, tawny owls have been known to attack and successfully chase off pine martens and have been seen to do the same to red foxes, cats and dogs.
https://en.wikipedia.org/wiki?curid=68959881
1,809,789
1,585,743
The art and science writer Peter Forbes notes that Thayer became obsessed by the "flattening effect" of countershading, and that far from being a scientist, he was "an artist whose idealist fervour, edged by deep insecurity, led him to regard his findings less as discovery than as revelation." Describing "Concealing-Coloration" as a "magnum opus", Forbes writes that by 1909 "Thayer's prophetic intolerance was in full flood", that he was overcompensating for his need for approval of his artwork, and that he failed to see that acceptance of ideas in science does not depend on "the vehemence with which they are expressed". In Forbes's view, Thayer was battling for the rights of artists over scientists, citing Thayer ("it properly belongs to the realm of pictorial art") in evidence. Apart from Thayer's "bizarre" flamingos, Forbes calls Thayer's opposition to Batesian mimicry "extreme". For Forbes, "Reading Thayer's book today is a strange experience. He sets out with the idea that "every single creature" is perfectly camouflaged", and then "tries to bludgeon his readers" into agreeing. Forbes is critical of Thayer's rejection of warning coloration, quoting Thayer's daughter Gladys as writing "My father's special mission was "tasting" butterflies"; Thayer apparently wanted to prove that mimicry was the wrong explanation as both model and mimic tasted the same. Forbes observes that natural selection did not have to contend with human reactions to the taste of butterflies.
https://en.wikipedia.org/wiki?curid=37724748
1,584,852
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It is one of the main structural units of the university, which operates in accordance with the charter and organizes its activities on the basis of orders and orders of the rector, as well as the Academic Council of the university. In recent years, the training of scientific and pedagogical personnel at the highest level of the education system has begun to acquire significantly different scales and goals: specialists of the highest scientific qualification today need not only scientific and educational universities, but also the healthcare sector, as well as knowledge-intensive industries that determine the success of the development of an innovative economy. Scientific councils for awarding the academic degree of candidate and doctor of sciences have been created and are effectively functioning at SSMU. In order to increase knowledge among young people in the field of innovative developments, the development of scientific thinking, independent work skills, and the development of creative abilities, the course "Fundamentals of Scientific Research and Innovative Activity", designed for 6 hours of training, has been introduced into the educational process of 4th year students in all areas of education. All conditions have been created for holding competitions for startup projects, an IT incubation center for startup projects has been opened, where favorable conditions will be reflected in the effective operation of small innovative projects, increasing their quality, quantity and implementation of original scientific and technical ideas among talented young people.
https://en.wikipedia.org/wiki?curid=66858162
1,560,533
1,205,304
The V-247 Vigilant is designed to weigh empty and carry of fuel, weapons, and sensors for a maximum gross weight of , roughly three times the maximum takeoff weight of the MQ-9. While the V-22 and V-280 use two engines located within the tiltrotor pylons, the V-247 will have a single engine housed in the fuselage generating 5,000-6,000 shp (3,670-4,410 kW), about as much as the V-22's engines. Wingspan is , just shorter than the Reaper's, with -diameter tilting rotors, smaller in diameter than the V-22's. Like the V-280, it has a V-shaped tail and one long wing piece mated to the top of the fuselage as well as retractable tricycle landing gear. To enable size compatibility with U.S. Navy guided missile destroyers, the wing and rotors swivel along the -long fuselage to have the same footprint as the UH-1Y Venom helicopter; two folded up V-247s can fit inside one C-17 Globemaster III transport aircraft. The aircraft aims to have a cruise speed of , a top speed of , and a service ceiling of , with a combat radius of and time-on-station of 11–15 hours while carrying a payload. Range is for 17 hours on internal fuel, and it has the capability for aerial refueling. The aircraft can support an internal mission payload of and can sling-load . The Vigilant is equipped with three internal payload bays, a centerline payload, and the capability to house up to two underwing pylons per side for various payloads including additional fuel, radar systems, LiDAR modules, sonobuoys, the Mark 50 torpedo, AGM-114 Hellfire, and Joint Air-to-Ground Missile (JAGM).
https://en.wikipedia.org/wiki?curid=51742817
1,204,659
1,248,582
Mild scoliosis (less than 30 degrees deviation) has traditionally been treated through observation only. However, the progression of adolescent idiopathic scoliosis has been linked to rapid growth, suggesting that observation alone is inadequate as progression can rapidly occur during the pubertal growth spurt. Another study has further shown that the peak rate of growth during puberty can actually be higher in individuals with scoliosis than those without, further exacerbating the issue of rapid worsening of the scoliosis curves. Moderately severe scoliosis (30–45 degrees) in a child who is still growing requires bracing. A 2013 study by Weinstein et al. found that rigid bracing significantly reduces worsening of curves in the 20-45 degree range and found that 58% of children receiving "observation only" progressed to surgical range. Recent guidelines published by the Scientific Society of Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT) in 2016 state that “the use of a brace is recommended in patients with evolutive idiopathic scoliosis above 25º during growth” based on a review of current scientific literature. Severe curvatures that rapidly progress may be treated surgically with spinal rod placement. Thus, early detection and early intervention prior to the pubertal growth spurt provides the greatest correction and prevention of progression to surgical range. In all cases, early intervention offers the best results. A growing body of scientific research testifies to the efficacy of specialized treatment programs of physical therapy, which may include bracing.
https://en.wikipedia.org/wiki?curid=51305509
1,247,906
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The TBM Council began as a biannual executive summit for CIOs sponsored by Apptio, which develops technology business management software as a service applications. In 2012, Apptio founded the TBM Council as a non-profit organization with a mission to identify and promote industry best practices for running technology organizations like a business. Upon incorporation, Apptio's Chief Marketing Officer (Chris Pick) became the president, and Chief Information Officers from Cisco (Rebecca Jacoby) and First American (Larry Godec) became co-chairs of the board of directors. In 2013, the Council held its first industry conference in Seattle and expanded its program into Europe in 2014. In 2015, the Council appointed Mike Brown, Vice President, Global Information Technology at ExxonMobil as its chairman of the board, created industry workgroups to define standards and launched a private and public sector IT COST Commission with the United States Federal Government. In 2016, the Council released their book and concluded the year-long IT COST Commission by making 21 recommendations to improve transparency, reduce waste and increase the efficiency of IT spending within the US Government.
https://en.wikipedia.org/wiki?curid=42693945
1,969,062
1,619,409
Human gastrodiscoidiasis is endemic in Assam, and to a lesser extent in the Philippines. The highest incidence so far recorded is among children in Kamrup district of Assam, where the prevalence was as high as 41%. First described from a native Assamese patient, it was initially believed to have a distribution restricted to NE India and the southeast Asia. Later investigations revealed that it is widespread, and is further spread by infected persons to other parts of the world, such as Guyana. The level of infection in laboratory animals can be very high among Asian mammals. Regions of high incidence can be attributed to low standard of sanitation, such as rural farms and villages where night soils are used. Infection in both humans and animals is most common through the ingestion of vegetation found in contaminated water. It is also assumed that transmission from infected fish that is under-cooked or eaten raw, as common among southeast Asian. There is a unique case report of a seven-year-old Nigerian who showed symptoms of malnutrition and anaemia and was eventually diagnosed with infections of "G. hominis" and "Ascaris lumbricoides". The child quickly recovered after proper medication.
https://en.wikipedia.org/wiki?curid=38751052
1,618,494
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The 19th-century English physiologist Sydney Ringer developed salt solutions containing the chlorides of sodium, potassium, calcium and magnesium suitable for maintaining the beating of an isolated animal heart outside the body. In 1885 Wilhelm Roux removed a section of the medullary plate of an embryonic chicken and maintained it in a warm saline solution for several days, establishing the basic principle of tissue culture. In 1907 the zoologist Ross Granville Harrison demonstrated the growth of frog embryonic cells that would give rise to nerve cells in a medium of clotted lymph. In 1913, E. Steinhardt, C. Israeli, and R. A. Lambert grew vaccinia virus in fragments of guinea pig corneal tissue. In 1996, the first use of regenerative tissue was used to replace a small length of urethra, which led to the understanding that the technique of obtaining samples of tissue, growing it outside the body without a scaffold, and reapplying it, can be used for only small distances of less than 1 cm. Ross Granville Harrison, working at Johns Hopkins Medical School and then at Yale University, published results of his experiments from 1907 to 1910, establishing the methodology of tissue culture.
https://en.wikipedia.org/wiki?curid=1106830
181,068
1,592,541
Due to the simple fabrication process, low production cost, and high efficiency, there is significant interest in dye-sensitized solar cells (DSSCs). Thus, improving DSSC efficiency has been the subject of a variety of research investigations because it has the potential to be manufactured economically enough to compete with other solar cell technologies. Titanium dioxide nanoparticles have been widely used as a working electrode for DSSCs because they provide a high efficiency, more than any other metal oxide semiconductor investigated. Yet the highest conversion efficiency under air mass (AM) 1.5 (100 mW/cm) irradiation reported for this device to date is about 11%. Despite this initial success, the effort to further enhance efficiency has not produced any major results. The transport of electrons across the particle network has been a key problem in achieving higher photoconversion efficiency in nanostructured electrodes. Because electrons encounter many grain boundaries during the transit and experience a random path, the probability of their recombination with oxidized sensitizer is increased. Therefore, it is not adequate to enlarge the oxide electrode surface area to increase efficiency because photo-generated charge recombination should be prevented. Promoting electron transfer through film electrodes and blocking interface states lying below the edge of the conduction band are some of the non-CNT based strategies to enhance efficiency that have been employed.
https://en.wikipedia.org/wiki?curid=17279558
1,591,644
562,155
In February 1973, State Rocket Center Makayev began development of a new two-stage liquid-fueled ballistic missile R-29R (3M40, RSM-50, SS-N-18). Improvements in the R-29R over the original R-29 include MIRVed capability and upgraded inertial navigation system with satellite-assisted navigation, giving the new missile greater accuracy (~), increasing its damage potential against all types of military targets whether "soft" or "hard." Fire control for the R-29R is achieved through the D-9R ballistic missile system, which contains sixteen SLBM tubes, just like the preceding Project 667BD. The Delta III class most often carried 16 of the R-29R (height: ; diameter: ; starting weight: 36.3 tons) missiles each carrying 3 MIRVs (0.2 мт each) with a range of about . They also can carry R-29RK with 7 (0.1 мт) MIRVs and range of about 6,500 km or R-29RL with single (0.45 мт) warhead and range of about . Coupled with the R-29R's capabilities and the performance of the D-9R, the Russian Navy possesses, for the first time, the ability to launch any number of its missiles in a single salvo with shorter launch intervals.
https://en.wikipedia.org/wiki?curid=2413980
561,866
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When defending the ball (i.e. guarding the man with the basketball) away from the basket in basketball, players typically should use a version of the following technique: the defender stands and faces the opponent. He is positioned halfway between the ball and the basket and may be angled in one direction or another depending on the defensive scheme of that defender's team. He has his feet positioned beyond shoulder width with most of the weight distributed to the balls of his feet. However, the defender's heels should not be off the floor as this will put him off balance. The defender's knees should be bent at roughly a ninety-degree angle with the bottom of his thighs parallel to the ground. This will place the defender's buttocks in a seated position. The defender's back should be straight with just a slight tilt forward. This will place the defender's head over the center of his body and maintain proper balance. Depending on the teachings of his coach, the defender should position his hands wide as if he were stretching his wingspan or place one hand high and one hand low. Keep at arm's length at all times. This allows the defender to be able to react quickly enough to anything that the attacker might do. It is ok to play a little farther back or even a little closer, it would just depend on how confident the player is in his abilities and the skill of the attacker. Keeping ayes on the opponent's chest is very helpful in reacting to their moves as well. It’s very easy for an offensive player to fake with their head, eyes, or body. The spot on a player that is most difficult to fake with is their chest.
https://en.wikipedia.org/wiki?curid=2046849
1,358,913
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At the end of Second World War, the "Luftwaffe"s most critical requirement was for interceptors as the Commonwealth and American air forces pounded German targets night and day. As the bombing effort grew, notably in early 1944, the Luftwaffe introduced a rocket-powered design, the Messerschmitt Me 163 "Komet", in the very-short-range interceptor role. The engine allowed about 7 minutes of powered flight, but offered such tremendous performance that they could fly right by the defending fighters. The Me 163 required an airbase, however, which were soon under constant attack. Following the Emergency Fighter Program, the Germans developed even odder designs, such as the Bachem Ba 349 "Natter", which launched vertically and thus eliminated the need for an airbase. In general all these initial German designs proved difficult to operate, often becoming death traps for their pilots, and had little effect on the bombing raids. Rocket-boosted variants of both of Germany's jet fighters; the Me 262 in its "C" subtype series, all nicknamed "home protector" ("Heimatschützer", in four differing formats) and the planned He 162E subtype, using one of the same BMW 003R turbojet/rocket "mixed-power" engine as the Me 262C-2b "Heimatschützer II", but were never produced in quantity.
https://en.wikipedia.org/wiki?curid=142759
119,004
267,201
Although ca. 80% of living animals are ectotherms, the knowledge about telomere dynamics in these species is still limited to a few studies in reptiles, fish, and amphibians, whereas invertebrates telomeres have been virtually not explored. Ectotherms are significantly more likely than endotherms to have variation in somatic telomerase expression. For instance, in many fish, telomerase occurs throughout the body (and associated with this, telomere length is roughly the same across all its tissue). Studies on ectotherms, and other non-mammalian organisms, show that there is no single universal model of telomere erosion; rather, there is wide variation in relevant dynamics across Metazoa, and even within smaller taxonomic groups these patterns appear diverse. Due to the different reproductive timelines of some ectotherms, selection on disease is relevant for a much larger fraction of these creatures’ lives than it is for mammals, so early- and late-life telomere length, and their possible links to cancer, seem especially important in these species from a life history theory point of view. Indeed, ectotherms are more sensitive to environmental variation than endotherms and factors such as temperature are known to their growth and maturation rates, thus, ectothermic telomeres are predicted to be greatly affected by climate change.
https://en.wikipedia.org/wiki?curid=54888
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Although it is now infrequent, individual aerial 1080 operations can still sometimes affect local bird populations if not carried out with sufficient care. In New Zealand, individuals from 19 species of native birds and 13 species of introduced birds have been found dead after aerial 1080 drops. Most of these recorded bird deaths were associated with only four operations in the 1970s that used poor-quality carrot baits with many small fragments. On the other hand, many native New Zealand bird populations have been successfully protected by reducing predator numbers through aerial 1080 operations. Kokako, blue duck, New Zealand pigeon, kiwi, kaka, New Zealand falcon, tomtit, South Island robin, North Island robin, New Zealand parakeets (kakariki), and yellowhead have all responded well to pest control programmes using aerial 1080 operations, with increased chick and adult survival, and increases in population size. In contrast, seven of 38 tagged kea, the endemic alpine parrot, were killed during an aerial possum control operation in Okarito Forest conducted by DOC and AHB in August 2011. Because of their omnivorous feeding habits and inquisitive behaviour, kea are known to be particularly susceptible to 1080 poison baits, as well as other environmental poisons like the zinc and lead used in the flashings of backcountry huts and farm buildings. Recent research found that proximity to human-occupied sites where kea scrounge human food is inversely related to survival; the odds of survival increased by a factor of 6.9 for remote kea compared to those that lived near scrounging sites. High survival in remote areas is explained by innate neophobia and a short field-life of prefeed baits, which together preclude acceptance of poison baits as familiar food.
https://en.wikipedia.org/wiki?curid=1190114
845,030
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For each of the three sciences, a working group was established headed by a full-time organiser, appointed for three years, and including a consultative committee of experts and six or seven team leaders, expert teachers on one-year appointments who headed local groups of half a dozen science teachers which would develop and test materials. The physics project was organised first, under Donald McGill; the chemistry project was under H. F. Halliwell, and the biology project under W. H. Dowdeswell. The initial focus on the course to 'O' level was extended to 'A' level and a Junior Science Project on primary school teaching was added by 1966; later in the 1960s Nuffield also began a Combined Science Project, a Secondary Science Project for pupils who would not take 'O' levels, the Nuffield Language Teaching Programme in modern languages, and programmes in mathematics, classics, and social studies. McGill died in March 1963 and was succeeded at the physics project by Eric M. Rogers. John Maddox was added as an assistant director of the foundation and coordinator of the project as a whole. In 1966 the development phase came to an end and teachers' guides, pupils' question books and other material were published in time for the school year starting in autumn 1967. Nuffield sponsored Area Committees, training of tutors to train teachers, television programmes on teaching Nuffield science, and two films showing actual chemistry classrooms: "Exploring Chemistry" and "Chemistry by Investigation". The Local Education Authority teachers' centres and specialist centres at teacher training institutions also provided training in Nuffield methods; the project itself established the Centre for Science Education at Chelsea College, which was able to grant degrees.
https://en.wikipedia.org/wiki?curid=48393333
1,784,070
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During 1952 Oppenheimer chaired the five-member State Department Panel of Consultants on Disarmament, which first urged that the United States postpone its planned first test of the hydrogen bomb and seek a thermonuclear test ban with the Soviet Union, on the grounds that avoiding a test might forestall the development of a catastrophic new weapon and open the way for new arms agreements between the two nations. The panel lacked political allies in Washington, however, and the Ivy Mike shot went ahead as scheduled. The panel then issued a final report in January 1953, which, influenced by many of Oppenheimer's deeply felt beliefs, presented a pessimistic vision of the future in which neither the United States nor the Soviet Union could establish an effective nuclear superiority but both sides could effect terrible damage on the other. One of the panel's recommendations, which Oppenheimer felt was especially important, was that the U.S. government practice less secrecy and more openness towards the American people about the realities of the nuclear balance and the dangers of nuclear warfare. This notion found a receptive audience in the new Eisenhower administration and led to creation of Operation Candor. Oppenheimer subsequently presented his view on the lack of utility of ever-larger nuclear arsenals to the American public with an article in "Foreign Affairs" in June 1953, and it received attention in major American newspapers.
https://en.wikipedia.org/wiki?curid=39034
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Once the astronauts returned to the vicinity of the LM and were again within view of the television camera, Shepard performed a stunt he had been planning for years in the event he reached the Moon, and which is probably what Apollo 14 is best remembered for. Shepard brought along a Wilson six iron golf club head, which he had modified to attach to the handle of the contingency sample tool, and two golf balls. Shepard took several one-handed swings (due to the limited flexibility of the EVA suit) and exuberantly exclaimed that the second ball went "miles and miles and miles" in the low lunar gravity. Mitchell then threw a lunar scoop handle as if it were a javelin. The "javelin" and one of the golf balls wound up in a crater together, with Mitchell's projectile a bit further. In an interview with Ottawa Golf, Shepard stated the other landed near the ALSEP. The second EVA lasted 4 hours, 34 minutes, 41 seconds. Shepard brought back the club, gave it to the USGA Museum in New Jersey, and had a replica made which he gave to the National Air and Space Museum. In February 2021, to commemorate Apollo 14's 50th anniversary, imaging specialist Andy Saunders, who had previously worked to produce the clearest image of Neil Armstrong on the Moon, produced new, digitally enhanced images that were used to estimate the final resting places of the two balls that Shepard hit - the first landed approximately 24 yards from the "tee", while the second managed 40 yards.
https://en.wikipedia.org/wiki?curid=1968
245,573
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Galaxy Zoo recruited volunteers to help with the largest galaxy census ever carried out. Opening the project to the general public saved the professional astronomers the task of studying all the galaxies themselves, resulting in classification of a large number of galaxies undertaken in a shorter time than what smaller research teams would be able to do, classifying 900,000 galaxies in months rather than years if done by smaller research teams. Computer programs had been unable to reliably classify galaxies: several groups had attempted to develop image-analysis programs. Kevin Schawinski stated: "The human brain is actually much better than a computer at these pattern recognition tasks." However, volunteers astonished the project's organizers by classifying the entire catalog years ahead of schedule. An online forum was later set up two weeks after the initial start, partially due to a large volume of emails being sent around, to the point that it was troublesome for those receiving them to process and respond to them. This led volunteers to point out anomalies that on closer inspection have turned out to be new astronomical objects such as 'Hanny's Voorwerp' and 'the Green Pea galaxies'. “I’m incredibly impressed by what they’ve managed to achieve,” says University of Oxford astronomer Roger Davies, former president of the Royal Astronomical Society.“They’ve made it possible to do things with a huge survey.”
https://en.wikipedia.org/wiki?curid=12212921
1,476,740
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Adults prefer to lay eggs on open grown or stressed ash but readily lay eggs on healthy trees amongst other tree species. Ashes that grow in pure stands, whether naturally occurring or in landscaping, are more prone to attack than isolated trees or ones located in mixed forest stands. Ashes used in landscaping also tend to be subjected to higher amounts of environmental stresses including compacted soil, lack of moisture, heating effects from urban islands, road salt, and pollution, which may also reduce their resistance to the borer. Furthermore, most ashes used in landscaping were produced from a handful of cultivars, resulting in low genetic diversity. Young trees with bark between to are preferred. Both males and females use leaf volatiles and sesquiterpenes in the bark to locate hosts. Damage occurs in infested trees by larval feeding. The serpentine feeding galleries of the larvae disrupt the flow of nutrients and water, effectively girdling, thus killing the tree, as it is no longer able to transport sufficient water and nutrients to the leaves to survive. Girdled ashes will often attempt to regenerate through stump sprouting, and there is evidence that stressed trees may also generate higher than normal seed crops as an emergency measure.
https://en.wikipedia.org/wiki?curid=1162925
767,023
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After returning from Leipzig with his doctorate, Whitney resumed working with Noyes in the laboratory. Whitney was intrigued by the competing theories of corrosion during his recent consulting assignment at a Boston hospital where rust plagued the water pipes. He designed an experiment to see whether carbonic acid, which was widely accepted to be necessary for rusting to occur, was really necessary. To do this, he examined corrosion through a physical chemistry approach. He reasoned that corrosion must occur in an oxidation-reduction reaction, similar to how Nernst explained the physical chemistry of a battery. His experiment then consisted of eliminating all traces of air, acid, and soluble alkali from sealed water bottles. He placed pieces of iron in the water bottles and sealed them with paraffin. Then he left the bottles on a shelf and checked to see if any rust had formed each day. Seeing as no rust formed for weeks, he decided to open them and let air in. Almost immediately, the water turned yellow and then rust started forming. Whitney reasoned that iron would not have dissolved between the time he opened the bottle and the formation of rust occurred. Thus, he reasoned that the iron dissolved into the water before he opened it, due to the hydrogen ion concentration. To verify his results, he sent his undergraduate students to gather more research. Based on Whitney's theory, hydrogen ions would be present during this process; one Whitney student verified this by opening up a rusty radiator and lighting a match. Hydrogen was present. Basically, Whitney found that the proper electrical contact between the cathode and anodic region as well as the presence of hydrogen ions were enough to make corrosion occur. He also found that keeping iron in an alkali solution could prevent rusting. He published his results in 1903 and earned immediate recognition in the American audience. However, Wilhelm Palmaer, one of Arrhenius's students in Sweden, published a similar article in 1901. While Whitney can not be credited for discovering corrosion theory, he did introduce it to the masses.
https://en.wikipedia.org/wiki?curid=6046838
2,003,353
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In May 2004, the Minister of Energy and Natural Resources Hilmi Güler said "We will meet with the countries that produce these plants soon" and brought the issue of nuclear power plant back to the agenda. In his statement, Güler stated that the technical investigations on nuclear power plants are continuing and that negotiations will be held soon. Güler announced that the construction of the first power plant will begin in 2007. In 2006, the northern Turkish city of Sinop, located near the Black Sea, was designated to host a commercial nuclear power plant. According to World Nuclear Association, the Sinop site has the advantage of cooling the water temperature approximately 5 degree Celsius lower than those at Akkuyu, helping each thermal reactor to achieve approximately 1 percent greater power output. A 100 MWe demonstration plant was to be installed there. Subsequently, 5000 MWe of additional plants were to come into operation from 2012 onwards. For construction and service, a form of public-private partnership (PPP) has been anticipated. The government said it aimed to have a total of 4500 MWe of energy running from three nuclear power stations by the end of 2015. Talks were happening with AECL over two 750 MWe CANDU reactors. The pressurized water reactor was also favoured by the government. The first reactors, totalling some 5000 MWe, were to be installed at Akkuyu, as the location already was approved. At the same time, the licensing for Sinop was still progressing.
https://en.wikipedia.org/wiki?curid=31197009
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Various claims have been made about the Dunning–Kruger effect's practical significance or why it matters. They often focus on how it causes the affected people to make decisions that lead to dire consequences for them or others. This is especially relevant for decisions that have long-term effects. For example, it can lead poor performers into careers for which they are unfit. High performers underestimating their skills, though, may forego viable career opportunities matching their skills in favor of less promising ones that are below their skill level. In other cases, the wrong decisions can also have severe short-term effects, as when overconfidence leads pilots to operate a new aircraft for which they lack adequate training or to engage in flight maneuvers that exceed their proficiency. Emergency medicine is another area where the correct assessment of one's skills and the risks of treatment is of central importance. The tendencies of physicians in training to be overconfident must be considered to ensure the appropriate degree of supervision and feedback. The Dunning–Kruger effect can also have negative implications for the agent in various economic activities, in which the price of a good, such as a used car, is often lowered by the buyers' uncertainty about its quality. An overconfident agent unaware of their lack of knowledge may be willing to pay a much higher price because they are unaware of all the potential flaws and risks relevant to the price.
https://en.wikipedia.org/wiki?curid=2288777
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Toxicity can be measured by its effects on the target (organism, organ, tissue or cell). Because individuals typically have different levels of response to the same dose of a toxic substance, a population-level measure of toxicity is often used which relates the probabilities of an outcome for a given individual in a population. One such measure is the . When such data does not exist, estimates are made by comparison to known similar toxic things, or to similar exposures in similar organisms. Then, "safety factors" are added to account for uncertainties in data and evaluation processes. For example, if a dose of a toxic substance is safe for a laboratory rat, one might assume that one-tenth that dose would be safe for a human, allowing a safety factor of 10 to allow for interspecies differences between two mammals; if the data are from fish, one might use a factor of 100 to account for the greater difference between two chordate classes (fish and mammals). Similarly, an extra protection factor may be used for individuals believed to be more susceptible to toxic effects such as in pregnancy or with certain diseases. Or, a newly synthesized and previously unstudied chemical that is believed to be very similar in effect to another compound could be assigned an additional protection factor of 10 to account for possible differences in effects that are probably much smaller. This approach is very approximate, but such protection factors are deliberately very conservative, and the method has been found to be useful in a deep variety of applications.
https://en.wikipedia.org/wiki?curid=170567
150,735
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As with all psychological research and psychometric evaluation, statistics play a vital role but should by no means be the sole basis for decisions and conclusions reached. Reasoned judgment is of critical importance when evaluating items for DIF. For instance, depending on the statistical procedure used for DIF detection, differing results may be yielded. Some procedures are more precise while others less so. For instance, the Mantel-Haenszel procedure requires the researcher to construct ability levels based on total test scores whereas IRT more effectively places individuals along the latent trait or ability continuum. Thus, one procedure may indicate DIF for certain items while others do not. Another issue is that sometimes DIF may be indicated but there is no clear reason why DIF exists. This is where reasoned judgment comes into play. The researcher must use common sense to derive meaning from DIF analyses. It is not enough to report that items function differently for groups, there needs to be a theoretical reason for why it occurs. Furthermore, evidence of DIF does not directly translate into unfairness in the test. It is common in DIF studies to identify some items that suggest DIF. This may be an indication of problematic items that need to be revised or omitted and not necessarily an indication of an unfair test. Therefore, DIF analysis can be considered a useful tool for item analysis but is more effective when combined with theoretical reasoning.
https://en.wikipedia.org/wiki?curid=9268401
1,380,249
1,559,782
In 1999, Pitt Stadium, the long-time home of the Pitt Panthers, was razed. Reminiscent of its days playing in Exposition Park, the team moved downtown to Heinz Field in 2001. A 12,508–seat multipurpose arena, the Petersen Events Center, is home to the University's basketball teams and convocation ceremonies and also contains a student recreation center. Other substantial building projects have occurred on campus, including renovation of the former Masonic Temple into Alumni Hall, construction of several new residence halls in the upper and lower campus, and construction of the Sennott Square building. Mark Nordenberg was chancellor of the University from 1995 to 2014, leading Pitt through a period of substantial progress, including the "Building our Future Together" campaign raising $2.135 billion across 188,000 donors and a $1-billion 12-year facilities plan. The current chancellor is Patrick D. Gallagher, who previously served as Director of the National Institute of Standards and Technology (NIST). Pitt's endowment reached $4.29 billion in the 2018-'19 fiscal year, ranking 20th among all college endowments.
https://en.wikipedia.org/wiki?curid=13999007
1,558,896
63,870
Railguns are being examined for use as anti-aircraft weapons to intercept air threats, particularly anti-ship cruise missiles, in addition to land bombardment. A supersonic sea-skimming anti-ship missile can appear over the horizon 20 miles from a warship, leaving a very short reaction time for a ship to intercept it. Even if conventional defense systems react fast enough, they are expensive and only a limited number of large interceptors can be carried. A railgun projectile can reach several times the speed of sound faster than a missile; because of this, it can hit a target, such as a cruise missile, much faster and farther away from the ship. Projectiles are also typically much cheaper and smaller, allowing for many more to be carried (they have no guidance systems, and rely on the railgun to supply their kinetic energy, rather than providing it themselves). The speed, cost, and numerical advantages of railgun systems may allow them to replace several different systems in the current layered defense approach. A railgun projectile without the ability to change course can hit fast-moving missiles at a maximum range of . As is the case with the Phalanx CIWS, unguided railgun rounds will require multiple/many shots to bring down maneuvering supersonic anti-ship missiles, with the odds of hitting the missile improving dramatically the closer it gets. The Navy plans for railguns to be able to intercept endoatmospheric ballistic missiles, stealthy air threats, supersonic missiles, and swarming surface threats; a prototype system for supporting interception tasks is to be ready by 2018, and operational by 2025. This timeframe suggests the weapons are planned to be installed on the Navy's next-generation surface combatants, expected to start construction by 2028.
https://en.wikipedia.org/wiki?curid=218930
63,845
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Kansas football dates from 1890, and is one of the oldest continuous programs in the nation. They have played in the Orange Bowl three times: 1948, 1969, and 2008, as well as nine other bowl games. They are currently coached by Lance Leipold, who was hired in May 2021. From its inception in 1890 to 1929 the program saw consistent success, winning several conference titles in 4 different conferences. After joining the Big 6 Conference (which would eventually become the Big 8) in 1929, Kansas began to struggle in the win-loss column. With the formation of the Big 8 conference in 1960, Kansas became a consistent winner again and fielded legendary coaches like Pepper Rodgers, Don Fambrough, Bud Moore, and Glen Mason. In 2008, under the leadership of Mark Mangino, the #7 Jayhawks emerged victorious in their first BCS bowl game, the FedEx Orange Bowl, with a 24–21 victory over the #3 Virginia Tech Hokies. This capstone victory marked the end of the most successful season in school history, in which the Jayhawks went 12–1 (.923). The team plays at David Booth Kansas Memorial Stadium, which recently underwent an $85 million renovation to add an indoor practice facility with a 120-yard field, an outdoor practice facility with 2 full fields and three partial fields, new locker rooms, a new weight training facility, new residencies for players, new offices, new turf, new seats, and a state-of-the-art video board.
https://en.wikipedia.org/wiki?curid=163327
398,275
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A 2014 review in "Nature Reviews Cancer" found that "contrary to the claimed mechanism of redirecting the flow of "qi" through meridians, researchers usually find that it generally does not matter where the needles are inserted, how often (that is, no dose-response effect is observed), or even if needles are actually inserted. In other words, 'sham' or 'placebo' acupuncture generally produces the same effects as 'real' acupuncture and, in some cases, does better." A 2013 meta-analysis found little evidence that the effectiveness of acupuncture on pain (compared to sham) was modified by the location of the needles, the number of needles used, the experience or technique of the practitioner, or by the circumstances of the sessions. The same analysis also suggested that the number of needles and sessions is important, as greater numbers improved the outcomes of acupuncture compared to non-acupuncture controls. There has been little systematic investigation of which components of an acupuncture session may be important for any therapeutic effect, including needle placement and depth, type and intensity of stimulation, and number of needles used. The research seems to suggest that needles do not need to stimulate the traditionally specified acupuncture points or penetrate the skin to attain an anticipated effect (e.g. psychosocial factors).
https://en.wikipedia.org/wiki?curid=1537
79,932
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Arthur Keith grew up in Quincy, Massachusetts, where he attended public school until he was 12 years old. After preparatory school at Adams Academy, he matriculated in 1881 at Harvard University. He graduated there with bachelor's degree in 1885 and A.M. in 1887. He was a student of Nathaniel Shaler. In 1887 Keith started work with the Massachusetts Topographic Survey. In the summer of that year he became assistant in a field party of the United States Geological Survey (USGS) and mapped areas in mountainous eastern Tennessee. At the end of the summer he went to Washington, D.C. and became a regular member of the USGS. He was assigned to Tennessee as field assistant to Bailey Willis, who was the director of the Appalachian Division. In 1889 Keith was elected a member of the Geological Society of America. His maps published between 1891 and 1907 gave detailed description of 15,000 square miles with much intricate bedrock structure. In 1906 he became chief of the Section of Areal Geology for all of the US. In 1913 the Section of Area Geology was divided was made into Eastern and Western Areas, with Keith in charge of the Eastern Area. During WW I he began a special study, requested by the US Army, in Maine, New Hampshire, and Vermont of geological features with possible military importance. In 1924 he withdrew from administrative work to work on the complex geology of northwestern Vermont and a geological map of Maine.
https://en.wikipedia.org/wiki?curid=67381332
2,098,109
937,725
Jessica Ulrika Meir (IPA: ; ; born ) is an American-Swedish NASA astronaut, marine biologist, and physiologist. She was previously an assistant professor of anesthesia at Harvard Medical School, Massachusetts General Hospital, Boston, following postdoctoral research in comparative physiology at the University of British Columbia. She has studied the diving physiology and behavior of emperor penguins in Antarctica, and the physiology of bar-headed geese, which are able to migrate over the Himalayas. In September 2002, Meir served as an aquanaut on the NASA Extreme Environment Mission Operations 4 () crew. In 2013, she was selected by NASA to Astronaut Group 21. In 2016, Meir participated in ESA CAVES, a training course in which international astronauts train in a space-analogue cave environment. Meir launched on September 25, 2019, to the ISS onboard Soyuz MS-15, where she served as a flight Engineer during Expedition 61 and 62. On October 18, 2019, Meir and Christina Koch were the first women to participate in an all-female spacewalk.
https://en.wikipedia.org/wiki?curid=33550544
937,225
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From an applied perspective, research in high-dimensional statistics was motivated by the realisation that advances in computing technology had dramatically increased the ability to collect and store data, and that traditional statistical techniques such as those described in the examples above were often ill-equipped to handle the resulting challenges. Theoretical advances in the area can be traced back to the remarkable result of Charles Stein in 1956, where he proved that the usual estimator of a multivariate normal mean was inadmissible with respect to squared error loss in three or more dimensions. Indeed, the James-Stein estimator provided the insight that in high-dimensional settings, one may obtain improved estimation performance through shrinkage, which reduces variance at the expense of introducing a small amount of bias. This bias-variance tradeoff was further exploited in the context of high-dimensional linear models by Hoerl and Kennard in 1970 with the introduction of ridge regression. Another major impetus for the field was provided by Robert Tibshirani's work on the Lasso in 1996, which used formula_52 regularisation to achieve simultaneous model selection and parameter estimation in high-dimensional sparse linear regression. Since then, a large number of other shrinkage estimators have been proposed to exploit different low-dimensional structures in a wide range of high-dimensional statistical problems.
https://en.wikipedia.org/wiki?curid=19330658
1,311,129
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In 2007 the use of vagotomy to treat obesity was being studied. The vagus nerve provides efferent nervous signals out from the hunger and satiety centers of the hypothalamus, a region of the brain central to the regulation of food intake and energy expenditure. The circuit begins with an area of the hypothalamus, the arcuate nucleus, that has outputs to the lateral hypothalamus (LH) and ventromedial hypothalamus (VMH), the brain's feeding and satiety centers, respectively. Animals with lesioned VMH will gain weight even in the face of severe restrictions imposed on their food intake, because they no longer provide the signaling needed to turn off energy storage and facilitate energy burning. In humans, the VMH is sometimes injured by ongoing treatment for acute lymphoblastic leukemia or surgery or radiation to treat posterior cranial fossa tumors. With the VMH disabled and no longer responding to peripheral energy balance signals, "[e]fferent sympathetic activity drops, resulting in malaise and reduced energy expenditure, and vagal activity increases, resulting in increased insulin secretion and adipogenesis." "VMH dysfunction promotes excessive caloric intake and decreased caloric expenditure, leading to continuous and unrelenting weight gain. Attempts at caloric restriction or pharmacotherapy with adrenergic or serotonergic agents have previously met with little or only brief success in treating this syndrome." The vagus nerve is thought to be one key mediator of these effects, as lesions lead to chronic elevations in insulin secretion, promoting energy storage in adipocytes.
https://en.wikipedia.org/wiki?curid=5591966
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In 1927, the first mathematically complete quantum description of a simple chemical bond, i.e. that produced by one electron in the hydrogen molecular ion, H, was derived by the Danish physicist Øyvind Burrau. This work showed that the quantum approach to chemical bonds could be fundamentally and quantitatively correct, but the mathematical methods used could not be extended to molecules containing more than one electron. A more practical, albeit less quantitative, approach was put forward in the same year by Walter Heitler and Fritz London. The Heitler–London method forms the basis of what is now called valence bond theory. In 1929, the linear combination of atomic orbitals molecular orbital method (LCAO) approximation was introduced by Sir John Lennard-Jones, who also suggested methods to derive electronic structures of molecules of F (fluorine) and O (oxygen) molecules, from basic quantum principles. This molecular orbital theory represented a covalent bond as an orbital formed by combining the quantum mechanical Schrödinger atomic orbitals which had been hypothesized for electrons in single atoms. The equations for bonding electrons in multi-electron atoms could not be solved to mathematical perfection (i.e., "analytically"), but approximations for them still gave many good qualitative predictions and results. Most quantitative calculations in modern quantum chemistry use either valence bond or molecular orbital theory as a starting point, although a third approach, density functional theory, has become increasingly popular in recent years.
https://en.wikipedia.org/wiki?curid=5993
367,285
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Photonic crystal sensors use photonic crystals: nanostructures composed of periodic arrangements of dielectric materials that interact with light depending on their particular structure, reflecting lights of specific wavelengths at specific angles. Any change in the periodicity or refractive index of the structure can give rise to a change in the reflected color, or the color perceived by the observer or a spectrometer. That simple principle makes them useful colorimetric intuitive sensors for different applications including, but not limited to, environmental analysis, temperature sensing, magnetic sensing, biosensing, diagnostics, food quality control, security, and mechanical sensing. Many animals in nature such as fish or beetles employ responsive photonic crystals for camouflage, signaling or to bait their prey. The variety of materials utilizable in such structures ranging from inorganic, organic as well as plasmonic metal nanoparticles makes these structures highly customizable and versatile. In the case of inorganic materials, variation of the refractive index is the most commonly exploited effect in sensing, while periodicity change is more commonly exhibited in polymer-based sensors. Besides their small size, current developments in manufacturing technologies have made them easy and cheap to fabricate on a larger scale, making them mass-producible and practical.
https://en.wikipedia.org/wiki?curid=67527532
1,833,144
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Ieoh Ming Pei ( ; ; April 26, 1917 – May 16, 2019) was a Chinese-American architect. Raised in Shanghai, Pei drew inspiration at an early age from the garden villas at Suzhou, the traditional retreat of the scholar-gentry to which his family belonged. In 1935, he moved to the United States and enrolled in the University of Pennsylvania's architecture school, but he quickly transferred to the Massachusetts Institute of Technology. He was unhappy with the focus at both schools on Beaux-Arts architecture, and spent his free time researching emerging architects, especially Le Corbusier. After graduating, he joined the Harvard Graduate School of Design (GSD) and became a friend of the Bauhaus architects Walter Gropius and Marcel Breuer. In 1948, Pei was recruited by New York City real estate magnate William Zeckendorf, for whom he worked for seven years before establishing an independent design firm in 1955, I. M. Pei & Associates. In 1966 that became I. M. Pei & Partners, and in 1989 became Pei Cobb Freed & Partners. Pei retired from full-time practice in 1990. In his retirement, he worked as an architectural consultant primarily from his sons' architectural firm Pei Partnership Architects.
https://en.wikipedia.org/wiki?curid=15155
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A group at Brown University ported version 9 to the IBM RT PC, but problems with reading unaligned data on the RT forced an incompatible protocol change, leading to version 10 in late 1985. By 1986, outside organizations had begun asking for X. X10R2 was released in January 1986, then X10R3 in February 1986. Although MIT had licensed X6 to some outside groups for a fee, it decided at this time to license X10R3 and future versions under what became known as the MIT License, intending to popularize X further and, in return, hoping that many more applications would become available. X10R3 became the first version to achieve wide deployment, with both DEC and Hewlett-Packard releasing products based on it. Other groups ported X10 to Apollo and to Sun workstations and even to the IBM PC/AT. Demonstrations of the first commercial application for X (a mechanical computer-aided engineering system from Cognition Inc. that ran on VAXes and remotely displayed on PCs running an X server ported by Jim Fulton and Jan Hardenbergh) took place at the Autofact trade show at that time. The last version of X10, X10R4, appeared in December 1986. Attempts were made to enable X servers as real-time collaboration devices, much as Virtual Network Computing (VNC) would later allow a desktop to be shared. One such early effort was Philip J. Gust's SharedX tool.
https://en.wikipedia.org/wiki?curid=34147
141,864
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In 2009 Priestley returned to the United States and joined the faculty at Princeton University. At Princeton, Priestley studies the nanoscale properties of materials, and how to tune these for novel device applications. He has continued to study the glass transition temperatures of polymers, with a focus on the controlled formation of thin films and nanocolloids. Priestley has studied the transition temperatures of substances that are composed of two or more polymers, attaching fluorescent reporting tags to the different components and using the brightness of the tag to infer whether the polymer is in a glassy or rubbery phase. As part of this work, Priestley studied plexiglas, a composite system of poly(methyl methacrylate) (PMMA) and poly(butyl methacrylate) (PBMA) that is found in coronary stents and paints. He combines experimental studies with computational investigations to better understand the distribution of the PMMA and PBMA throughout the plexiglass. Through his understanding of phase transitions, Priestley has shown that it is possible to precisely control nanostructures, and realised self-assembled biopolymers for use in artificial skin. Alongside his work on polymeric systems, Priestley has investigated nanoparticles, specifically engineered nanoscale zerovalent iron (enZVI) particles, as a means to clean groundwater. He proposed the use of Janus particles for the use in surfactant-free cleansing.
https://en.wikipedia.org/wiki?curid=64628515
1,883,848
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General Emmons returned to the U.S. with details of the British night-fighter requirements, and in his report said that the design departments of the American aviation industry's firms could possibly produce such an aircraft. The Emmons Board developed basic requirements and specifications, handing them over towards the end of 1940 to the Air Technical Service Command (ATSC) at Wright Field, Ohio. After considering the two biggest challenges—the heavy weight of the AI radar and the very long (by fighter standards) loiter time of eight hours minimum—the board, including Jack Northrop, realized the aircraft would need the considerable power and resulting size of twin engines, and recommended such parameters. The United States had two twin-row radials of at least 46 liters displacement in development since the late 1930s; the Double Wasp and the Duplex Cyclone. These engines had been airborne for their initial flight tests by the 1940/41 timeframe, and were each capable, with more development, of exceeding .
https://en.wikipedia.org/wiki?curid=458868
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"Bordetella avium" has a worldwide distribution but is found at the highest density in the North Temperate Zone, between the arctic circle and the Tropic of Cancer where the climate is most conducive to transfer. Seasonality of outbreaks are most often recorded during the summer and fall months. Outbreaks have been recorded in many countries including the United States, Canada, Australia, Germany, France, and South Africa. When infections do occur nearly all of the flock becomes affected leading to a high reported morbidity with low mortality. Severity of disease can be exacerbated by adverse environmental conditions (low temperature, high ammonia and dust, low humidity) and secondary bacterial infections; increasing mortality up to 40% or 60%. It is uncommon to see outbreaks in breeder flocks, but up to 20% morbidity with no mortality is reported. Furthermore, the bacterium is highly contagious and transmissible and the prevalence in bird species is abundant. Small backyard turkey flocks a mile from large commercial farms have shown isolated infections of "B. avium." B. avium is not able to transmit via vertical transmission, but it can transmit by direct contact between birds and remain in the environment in litter, food, and water for as long as 6 months."B. avium" also has a short incubation of only 7–10 days allowing for easy and rapid transmission.
https://en.wikipedia.org/wiki?curid=40064924
1,913,645
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Organized races on ice skates developed in the 19th century. Norwegian clubs hosted competitions from 1863, with races in Christiania drawing five-digit crowds. In 1884, the Norwegian Axel Paulsen was named Amateur Champion Skater of the World after winning competitions in the United States. Five years later, a sports club in Amsterdam held an ice-skating event they called a world championship, with participants from Russia, the United States and the United Kingdom, as well as the host country. The "Internationale Eislauf Vereinigung", now known as the International Skating Union, was founded at a meeting of 15 national representatives in Scheveningen in 1892, the first international winter sports federation. The Nederlandse Schaatsrijderbond was founded in 1882 and organised the world championships of 1890 and 1891. Competitions were held around tracks of varying lengths—the 1885 match between Axel Paulsen and Remke van der Zee was skated on a track of 6/7 mile (1400 metres)—but the 400 metre track was standardised by the ISU in 1892, along with the standard distances for world championships, 500 m, 1500 m, 5000 m and 10,000 m. Skaters started in pairs, each to their own lane, and changed lanes for every lap to ensure that each skater completed the same distance. This is what is now known as long track speed skating. Competitions were exclusively for amateur skaters, which was enforced. Peter Sinnerud was disqualified for professionalism in 1904 and lost his world title.
https://en.wikipedia.org/wiki?curid=28028
936,684
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Since 2007, conditions in Guiyu have changed little despite the efforts of the central government to crack down and enforce the long-standing e-waste import ban. However, because of the work of activist groups and increasing awareness of the situation, the local government has created steps to improve environmental conditions. "It can be done. Look at what happened with lead acid batteries. We discovered they were hazardous, new legislation enforced new ways of dealing with the batteries which led to an infrastructure being created. The key was making it easy for people and companies to participate. It took years to build. E-waste is going the same route. But attitudes have changed and we will get there", says Robert Houghton, president and founder of Redemtech, an asset management and recovery firm. Zheng Songming, head of the Guiyu Township government has published a decree to ban burning electronics in fires and soaking them in sulfuric acid, and promises supervision and fines for violations. Over 800 coal-burning furnaces have been destroyed because of this ordinance, and most notably, air quality has returned to Level II, now technically acceptable for habitation.
https://en.wikipedia.org/wiki?curid=22995310
1,411,790
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On 3 July, Barcelona announced that La Masia graduate Martín Montoya would join Italian side Internazionale on a season-long loan with an option for a second. On 6 July, Barcelona announced the signing of Turkey national team captain Arda Turan from Atlético Madrid for €34 million. The player will join on 1 January 2016 after the FIFA transfer ban is lifted. On 18 July, Josep Bartomeu was elected president of Barcelona for the next six years with the third most votes in the club's history. On 21 July, Barcelona kicked off the preseason with a 1–2 victory over Major League Soccer champions LA Galaxy in the 2015 International Champions Cup. Goals from Luis Suárez and Sergi Roberto secured the win in front of a crowd of 93,226 at the Rose Bowl in Pasadena, California. On 23 July, Barcelona were fined €30,000 by UEFA for fans waving pro-Catalan independence banners at the 2015 UEFA Champions League Final. The club maintains its respect for the sanction, yet does not agree with it and its legal services will consider the possibility of questioning the fine at a later time. On 25 July, Barcelona were defeated by English side Manchester United with a scoreline of 1–3 at Levi's Stadium in Santa Clara, California. The lone goal came from Rafinha in the 89th minute of play. On 28 July, Barcelona were defeated in penalties by Chelsea at FedExField in Landover, Maryland. Goals from Luis Suárez and Sandro were enough to earn the regular time draw, however the team lost in penalties 4–2 to end their United States Summer Tour.
https://en.wikipedia.org/wiki?curid=46735387
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Christie's early research focused on heterosynaptic plasticity in the hippocampal formation. During the course of this work, he discovered that prior synaptic activity could impact the capacity for synapses to subsequently show activity-dependent forms of plasticity, a phenomenon that he originally called "priming" but that has since been termed "metaplasticity". He completed a PhD at the University of Otago in 1993. His Ph.D. work generated 9 publications on synaptic plasticity with Abraham. Following the completion of his Ph.D., he became interested in how calcium entered neurons, and began a post-doctoral fellowship with Dan Johnston. In this period he showed for the first time, using calcium imaging, that different types of voltage-gated calcium channels were not distributed homogeneously throughout neuron dendrites and somata. Moreover, he was able to show that certain types of voltage-gated channels played a preferential role in long-term forms of synaptic depression, or LTD. Despite lasting only 2.5 years, this post-doctoral fellowship generated 8 publications. In 1996, Christie turned down several job offers at Canadian institutions and moved to the Salk Institute to work with T. Sejnowski. While his aspirations for becoming more involved in the computational modeling the Sejnowski lab was known for were not realized, it was during this period that met Dr.'s Henriette van Praag and Fred "Rusty"Gage and became interested in neurogenesis. Together these individuals published four influential publications on adult hippocampal neurogenesis, with Christie performing the majority of the electrophysiological recordings.
https://en.wikipedia.org/wiki?curid=6841939
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This is the very first example of a ligated heterometallic Mackay-type cluster, which is an extremely complex crystal structure whose surface is composed of two-shell 20 equilateral triangles composed of 55 copper and aluminum atoms. This shape is also called an icosahedron. The 43 copper and 12 aluminum atoms form a superatom by the metals forming a shared electron shell that resembles a single metal atom. Through magnetic data and analysis at the DFT level it shows that this superatom has a very unique electronic structure of the cluster which is a 67-electron open jellium shell [CuAl] core, protected by twelve Cp* ligands. These crystals have the chemical properties of individual copper atoms. They are attracted by a magnetic field, or paramagnetic due to three valence electrons in the outermost shell whose spin align themselves in a magnetic field. Another property of this compound is that it is pyrophoric, or can ignite spontaneously when exposed to air, so it is highly sensitive to the air and moisture. Also, this compound cannot be re-dissolved in any solvent without decomposition, which means extensive characterization of the compound cannot be obtained with high-resolution mass spectrometry or solution NMR spectroscopy. Thus X-ray diffraction structural analysis of the data obtained does not meet the accepted high-quality requirements, due to the compound forming relatively small, weakly diffracting cubes when using single crystals.
https://en.wikipedia.org/wiki?curid=59257416
2,204,309
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An atmospheric diving suit is a small one-man articulated submersible of roughly anthropomorphic form, with limb joints which allow articulation under external pressure while maintaining an internal pressure of one atmosphere. Breathing gas supply could be surface supplied by umbilical, but would then have to be exhausted back to the surface to maintain internal pressure below the external ambient pressure, which is possible but presents pressure-hull breach hazards if the umbilical hoses are damaged, or from a rebreather system built into the suit. As there is a similar problem in venting excess gas, the simple and efficient solution is to make up oxygen as it is consumed and scrub out the carbon dioxide, with no change to the inert gas component, which simply recirculates. In effect, a simple closed circuit oxygen rebreather arrangement used as a life-support system. Since there is usually an adequate power supply for other services, powered circulation through the scrubber should not normally be an issue for normal service, and is more comfortable for the operator, as it keeps the face area clear and facilitates voice communication. As the internal pressure is maintained at one atmosphere, there is no risk of acute oxygen toxicity. Endurance depends on the scrubber capacity and oxygen supply. Circulation through the scrubber could be powered by the diver's breathing, and this is an option for an emergency backup rebreather, which may also be fitted to the suit. A breathing driven system requires reduction of mechanical dead space by using a mouthpiece and counterlung to form a closed loop.
https://en.wikipedia.org/wiki?curid=62138749
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In February 1937, Lieutenant Benjamin S. Kelsey, Project Officer for Fighters at the United States Army Air Corps (USAAC), and Captain Gordon P. Saville, fighter tactics instructor at the Air Corps Tactical School, issued a specification for a new fighter via Circular Proposal X-609. It was a request for a single-engine high-altitude "interceptor" having "the tactical mission of interception and attack of hostile aircraft at high altitude". Despite being called an interceptor, the proposed aircraft's role was simply an extension of the traditional pursuit (fighter) role, using a heavier and more powerful aircraft at higher altitude. Specifications called for at least of heavy armament including a cannon, a liquid-cooled Allison engine with a General Electric turbo-supercharger, tricycle landing gear, a level airspeed of at least at altitude, and a climb to within 6 minutes. This was the most demanding set of fighter specifications USAAC had presented to that date. Although Bell's limited fighter design work had previously resulted in the unusual Bell YFM-1 Airacuda, the Model 12 proposal adopted an equally original configuration with an Allison V-12 engine mounted in the middle of the fuselage, just behind the cockpit, and a propeller driven by a shaft passing beneath the pilot's feet under the cockpit floor.
https://en.wikipedia.org/wiki?curid=458867
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Limitations have been strongly felt in protein structure refinement. The major underlying challenge is the huge conformation space of polymeric molecules, which grows beyond current computational feasibility when containing more than ~20 monomers. Participants in "Critical Assessment of protein Structure Prediction" (CASP) did not try to refine their models to avoid ""a central embarrassment of molecular mechanics, namely that energy minimization or molecular dynamics generally leads to a model that is less like the experimental structure"". Force fields have been applied successfully for protein structure refinement in different X-ray crystallography and NMR spectroscopy applications, especially using program XPLOR. However, the refinement is driven mainly by a set of experimental constraints and the interatomic potentials serve mainly to remove interatomic hindrances. The results of calculations were practically the same with rigid sphere potentials implemented in program DYANA (calculations from NMR data), or with programs for crystallographic refinement that use no energy functions at all. These shortcomings are related to interatomic potentials and to the inability to sample the conformation space of large molecules effectively. Thereby also the development of parameters to tackle such large-scale problems requires new approaches. A specific problem area is homology modeling of proteins. Meanwhile, alternative empirical scoring functions have been developed for ligand docking, protein folding, homology model refinement, computational protein design, and modeling of proteins in membranes.
https://en.wikipedia.org/wiki?curid=2916615
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In late 2013 U.S. President Barack Obama made recommendations to the Presidential Commission for the Study of Bioethical Issues as part of his $100 million Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative. This Spring discussion resumed in a recent interview and article sponsored by Agence France-Presse (AFP): "It is absolutely critical... to integrate ethics from the get-go into neuroscience research," and not "for the first time after something has gone wrong", said Amy Gutmann, Bioethics Commission Chair." But no consensus has been reached. Miguel Faria, a Professor of Neurosurgery and an Associate Editor in Chief of Surgical Neurology International, who was not involved in the Commission's work said, "any ethics approach must be based upon respect for the individual, as doctors pledge according to the Hippocratic Oath which includes vows to be humble, respect privacy and doing no harm; and pursuing a path based on population-based ethics is just as dangerous as having no medical ethics at all". Why the danger of population-based bioethics? Faria asserts, "it is centered on utilitarianism, monetary considerations, and the fiscal and political interests of the state, rather than committed to placing the interest of the individual patient or experimental subject above all other considerations". For her part, Gutmann believes the next step is "to examine more deeply the ethical implications of neuroscience research and its effects on society".
https://en.wikipedia.org/wiki?curid=703002
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Breakfast began at 7 a.m. Astronauts usually stood to eat, as sitting in microgravity also strained their abdominal muscles. They reported that their food although greatly improved from Apollo was bland and repetitive, and weightlessness caused utensils, food containers, and bits of food to float away; also, gas in their drinking water contributed to flatulence. After breakfast and preparation for lunch, experiments, tests and repairs of spacecraft systems and, if possible, 90 minutes of physical exercise followed; the station had a bicycle and other equipment, and astronauts could jog around the water tank. After dinner, which was scheduled for 6 p.m., crews performed household chores and prepared for the next day's experiments. Following lengthy daily instructions (some of which were up to 15 meters long) sent via teleprinter, the crews were often busy enough to postpone sleep. The station offered what a later study called "a highly satisfactory living and working environment for crews", with enough room for personal privacy. Although it had a dart set, playing cards, and other recreational equipment in addition to books and music players, the window with its view of Earth became the most popular way to relax in orbit.
https://en.wikipedia.org/wiki?curid=29441
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On 26 December 2021, Shenzhou 13 crew Zhai Zhigang and Ye Guangfu conducted the second spacewalk to install a panoramic camera, which will be used for space station monitoring and robotic arm observation. They also practiced various movements with the help of "Chinarm" controlled by the monitoring astronaut Wang Yaping inside the station. During the construction phase of the station in 2021, according to documents filed by China Manned Space Agency (CMSA) with the United Nations Office for Outer Space Affairs and reported by Reuters, the station had two "close encounters" with SpaceX's Starlink satellites on July 1 and October 21, with the station conducting evasive adjustment maneuvers. On 5 January 2022, Shenzhou 13 team used the 10-meter long "Chinarm" to relocate the Tianzhou 2 supply ship by 20 degrees before returning it to the original location. This maneuver was conducted to practice the procedures, equipment, and backup operation system needed for future module assembly. On January 13, the crew tested the emergency docking system by controlling the cargo spacecraft manually. In March 2022, Shenzhou 13 crew began the preparation to undock from the space station. The crew landed in China on 16 April 2022, after staying 182 days in the low-Earth orbit. Soon afterward, China launched Tianzhou 4 cargo spacecraft in preparation for the next crewed mission in May. The automated freighter docked with the space station on 9 May 2022, and carried vital maintenance equipment and a refrigerator for scientific experiment.
https://en.wikipedia.org/wiki?curid=2481401
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Not all methods of opening the zona pellucida have the same success rate because the well-being of the embryo and/or blastomere may be impacted by the procedure used for the biopsy. Zona drilling with acid Tyrode's solution (ZD) was looked at in comparison to partial zona dissection (PZD) to determine which technique would lead to more successful pregnancies and have less of an effect on the embryo and/or blastomere. ZD uses a digestive enzyme like pronase which makes it a chemical drilling method. The chemicals used in ZD may have a damaging effect on the embryo. PZD uses a glass microneedle to cut the zona pellucida which makes it a mechanical dissection method that typically needs skilled hands to perform the procedure. In a study that included 71 couples, ZD was performed in 26 cycles from 19 couples and PZD was performed in 59 cycles from 52 couples. In the single-cell analysis, there was a success rate of 87.5% in the PZD group and 85.4% in the ZD group. The maternal age, number of oocytes retrieved, fertilization rate, and other variables did not differ between the ZD and PZD groups. It was found that PZD led to a significantly higher rate of pregnancy (40.7% vs 15.4%), ongoing pregnancy (35.6% vs 11.5%), and implantation (18.1% vs 5.7%) than ZD. This suggests that using the mechanical method of PZD in blastomere biopsies for preimplantation genetic diagnosis may be more proficient than using the chemical method of ZD. The success of PZD over ZD could be attributed to the chemical agent in ZD having a harmful effect on the embryo and/or blastomere. Currently, zona drilling using a laser is the predominant method of opening the zona pellucida. Using a laser is an easier technique than using mechanical or chemical means. However, laser drilling could be harmful to the embryo and it is very expensive for in vitro fertilization laboratories to use especially when PGD is not a prevalent process as of modern times. PZD could be a viable alternative to these issues.
https://en.wikipedia.org/wiki?curid=562180
630,093
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Around 1996, when the project had conditional funding but no final approval, several critics, including academics and University District residents opposed the proposed building plan, arguing that UW was breaking its agreement with the city over how the UW campus should be developed, that it would remove one of the few remaining open spaces on campus, that it was a bad spending of educational dollars during a budget crisis, and that the project was "leapfrogged" over higher priority projects. The university originally planned to construct a replacement law facility on Parrington Green, but after outcry that lead to almost 600 e-mail messages expressing disfavor with the plan being sent during the first twelve days of February 1996, an administration committee revealed a revised plan that would reduce the building's footprint by about a third of the original plan, saving more of the park. The university later changed the location to the N1 Parking Lot, near the Burke Museum. This decision prevented the destruction of a group of trees, and in the words of Sherri Olson of the "Seattle Post-Intelligencer", "define[d] a new quad."
https://en.wikipedia.org/wiki?curid=34948681
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The German-South African Year of Science brought together scientists from both countries under the slogan "Enhancing Science Partnerships for Innovation and Sustainable Development" to focus on seven thematic fields: climate change, bioeconomy, urbanization, health innovation, astronomy, social sciences & humanities, and human capital development. One of the most important focus areas of German-South African research activity during the Year of Science was and still is research on climate change, its causes and effects. Projects and workshops on the topic were organized which focussed on closed ecosystems, biodiversity, management of water resources or changes in soils. A total of 200 events took place during the year, including the first joint German-South African expedition to Antarctica on the research vessel Polarstern. The ministries of the two countries sponsored 41 projects in the framework of an ideas competition; contests at schools, summer schools, lecture series and specialist conferences were also held. The establishment of a joint research chair was agreed at the end of the Science Year which will be devoted to one of the seven thematic fields and located at one of South Africa's top universities. Furthermore, the Alexander von Humboldt Foundation launched the ‘Neville Alexander Memorial Fund’ with support from the German Federal Ministry of Education and Research (BMBF).
https://en.wikipedia.org/wiki?curid=40565294
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Eels in the family "Anguillidae" are known to be primarily solitary in nature; they are not known to communicate socially or actively school, however large masses of elvers can be found as a result of synchronicity in response to environmental conditions. These eels are known as generalists and opportunistic feeders; most will consume whatever acceptable prey they happen upon, including things like crustaceans, fishes, and other aquatic fauna. Aside from their reduced pectoral fins, eels lack of paired appendages: use axial-based lateral undulation as means of locomotion, similar to snakes. High maneuverability of trunk is adaptation for hunting in structurally-complex habitats such as reefs. Some species are known to burrow into the sea bed/sediment, including species that utilize head-first or tail-first burrowing techniques. This is related to both foraging and anti-predatory behavior. Freshwater eels have several natural predators such as large fish and piscivorous birds.  Much is unknown about Anguillid eel behavior and its origins, due to the difficulty in observation, particularly in the context of reproduction, social constructs, and migration.
https://en.wikipedia.org/wiki?curid=2349109
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Chest-wall defects are usually evident in cases of injury to the chest wall, such as stab or bullet wounds ("open pneumothorax"). In secondary spontaneous pneumothoraces, vulnerabilities in the lung tissue are caused by a variety of disease processes, particularly by rupturing of bullae (large air-containing lesions) in cases of severe emphysema. Areas of necrosis (tissue death) may precipitate episodes of pneumothorax, although the exact mechanism is unclear. Primary spontaneous pneumothorax (PSP) has for many years been thought to be caused by "blebs" (small air-filled lesions just under the pleural surface), which were presumed to be more common in those classically at risk of pneumothorax (tall males) due to mechanical factors. In PSP, blebs can be found in 77% of cases, compared to 6% in the general population without a history of PSP. As these healthy subjects do not all develop a pneumothorax later, the hypothesis may not be sufficient to explain all episodes; furthermore, pneumothorax may recur even after surgical treatment of blebs. It has therefore been suggested that PSP may also be caused by areas of disruption (porosity) in the pleural layer, which are prone to rupture. Smoking may additionally lead to inflammation and obstruction of small airways, which account for the markedly increased risk of PSPs in smokers. Once air has stopped entering the pleural cavity, it is gradually reabsorbed.
https://en.wikipedia.org/wiki?curid=286359
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Conflicts with the placement of solar plants require researching the population density of nearby towns and/or urban areas, as the solar plants and solar fields will cause visual disruptions and potential emission of pollutants. Areas that allow for easy access to the solar panels for repair, the clearing of overgrown vegetation, and routine panel washing are ideal, as well as being located close to roads to decrease further building costs of additional roads and service pathways and to avoid inaccessibility to service vehicles. Being located close the power grid will also lower the cost of transmission and the loss of power, decreasing the economical strain put on the area for building costs and shortening the amount of time until the original cost is overshadowed by the solar plant or field's production. Original or continued land use or cover must also be taken into consideration as areas with large topographic feature will have a tendency to be shadowed more heavily. Areas with large quantities of trees could be overshadowed or have an increased risk of destruction in inclement weather. Locales with poor soil, heavy metal contamination, erosion, or are unfit for rural or urbanization could be used for solar energy production—reducing the need to buy out farmers, disrupt pristine areas, and lessen the effect on surrounding habitats.
https://en.wikipedia.org/wiki?curid=32793086
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In a series of joint papers with Kenneth Wolpin, published between 1994 and 2010, Keane developed a major line of research on dynamic life-cycle models of career (i.e., school and work) choices. This line of research is notable both for the methodological contributions on how to estimate these types of models, and for its substantive economic contributions. Methodologically, their method of approximating the solution to computationally intensive dynamic programming problems led to a great expansion in the class of such models that are feasible to implement empirically (i.e., their method made it possible to estimate models with many more choices and state variables than was possible previously). Substantively, their seminal 1997 paper on "The Career Decisions on Young Men" presented the so-called "90 percent result"—i.e., that most of what matters for lifetime earnings has already happened by age 16. This result helped to shift the focus of the human capital literature away from college education and towards early childhood education. This is now a very active area of research in economics, which has been pursued by both Keane and Wolpin and, quite notably, by the Nobel Prize–winning economist James Heckman, among others.
https://en.wikipedia.org/wiki?curid=41233307
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The invariant decomposition finds its roots in a statement made by Marcel Riesz about bivectors:Can any bivector formula_9 be decomposed into the direct sum of mutually orthogonal simple bivectors?Mathematically, this would mean that for a given bivector formula_9 in an formula_67 dimensional geometric algebra, it should be possible to find a maximum of formula_68 bivectors formula_16, such that formula_70, where the formula_16 satisfy formula_72 and should square to a scalar formula_73. Marcel Riesz gave some examples which lead to this conjecture, but also one (seeming) counter example. A first more general solution to the conjecture in geometric algebras formula_74 was given by David Hestenes and Garret Sobczyck. However, this solution was limited to purely Euclidean spaces. In 2011 the solution in formula_75 (3DCGA) was published by Leo Dorst and Robert Jan Valkenburg, and was the first solution in a Lorentzian signature. Also in 2011, Charles Gunn was the first to give a solution in the degenerate metric formula_76. This offered a first glimpse that the principle might be metric independent. Then, in 2021, the full metric and dimension independent closed form solution was given by Martin Roelfs in his PhD thesis. And because bivectors in a geometric algebra formula_10 form the Lie algebra formula_78, the thesis was also the first to use this to decompose elements of formula_52 groups into orthogonal commuting factors which each follow Euler's formula, and to present closed form exponential and logarithmic functions for these groups. Subsequently in a paper by Martin Roelfs and Steven De Keninck the invariant decomposition was extended to include elements of formula_1, not just formula_52, and the direct decomposition of elements of formula_52 without having to pass through formula_78 was found.
https://en.wikipedia.org/wiki?curid=69262097
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Mearsheimer's second book, "Liddell Hart and the Weight of History" (1988), reassesses the intellectual legacies of the 20th-century British military theorist B. H. Liddell Hart. While acknowledging that his own research had "profited greatly from his stimulating writings" and that Liddell Hart's works should still be considered "essential reading for serious students of strategy and warfare" (p. x), Mearsheimer argues that much of the conventional wisdom on Liddell Hart's contributions to modern military thought was flawed. In particular, the theory of the indirect approach, which Liddell Hart developed in the 1930s, is so vague and tautological that "virtually every military victory can be ascribed to [it]." (p. 87). Moreover, Liddell Hart's limited attempts to operationalize the theory clearly indicated that what he primarily had in mind was to "indirectly" defeat a continental adversary by "break[ing] the morale of the enemy's civilian population, not to destroy his military forces, which of course is what the blitzkrieg is concerned with" (p. 88). The common practice of tracing the intellectual origins of the blitzkrieg strategy to the indirect approach is thus mistaken since there was "no evidence... that Liddell Hart understood the importance of the deep strategic penetration [that distinguishes "blitzkrieg"] "before" World War II" (p. 43). Not surprisingly, Liddell Hart was proven utterly wrong on the fundamental military questions of the interwar period; he dismissed the possibility of a decisive German offensive in the Western front) and fell into disrepute in the immediate aftermath of the war.
https://en.wikipedia.org/wiki?curid=980934
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In addition to this, peptide amphiphiles can be used to form more sophisticated architectures which can be tuned on demand. In recent years, two discoveries have yielded bioactive materials with more advanced structures and potential applications. In one study, a thermal treatment of peptide amphiphile solutions led to the formation of large birefringent domains in the material that could be aligned by a weak shear force into one continuous monodomain gel of aligned nanofibers. The low shear forces used in aligning the material permit the encapsulation of living cells inside these aligned gels and suggest several applications in regenerating tissues that rely on cell polarity and alignment for function. In another study, the combination of positively charged peptide amphiphiles and negatively charged long biopolymers led to the formation of hierarchically ordered membranes. When the two solutions are brought into contact, electrostatic complexation between the components of each solution creates a diffusion barrier that prevents the mixing of the solutions. Over time, an osmotic pressure difference drives the reptation of polymer chains through the diffusion barrier into the peptide amphiphile compartment, leading to the formation of fibers perpendicular to the interface that grow over time. These materials can be made in the form of flat membranes or as spherical sacs by dropping one solution into the other. These materials are robust enough to handle mechanically and a range of mechanical properties can be accessed by altering growth conditions and time. They can incorporate bioactive peptide amphiphiles, encapsulate cells and biomolecules, and are biocompatible and biodegradable.
https://en.wikipedia.org/wiki?curid=28333458
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Ferrari was the great favorite with a 3-litre version of his well tested powerful sports car V12 design, but the new cars were very heavy, probably in an excess of self-confidence. An enlarged V6 held some promise but Surtees left mid-season after a dispute with team manager Eugenio Dragoni at the 24 Hours of Le Mans sportscar race. Coventry-Climax, formerly supplier to much of the field, pulled out of the sport leaving teams like Lotus to struggle with enlarged versions of obsolete Climax engines. Cooper turned to a development of an otherwise obsolete Maserati V12 that was originally designed for the Maserati 250 F in the late 1950s, while BRM made the choice to design an incredibly heavy and complex H-16. The big winner was Jack Brabham, whose eponymous racing team took victory two years running with a light and compact spaceframe chassis powered by the aluminium-block stock-derived Repco V8 unit. With SOHC heads and no more than 330 bhp, the Repco was one of the least powerful of the new 3-litre engines but unlike the others it was light, reliable and available right from the start of the new rules. 1966 was Jack's year, while went to his teammate, New Zealander Denny Hulme, as Jack tried new parts on his car.
https://en.wikipedia.org/wiki?curid=640098
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More recently, the European Commission, on behalf of its 27 member states, is also making greater use of green finance, especially green bond (see green bonds section) to finance part of NextGenerationEU. The aim of this initiative is to relaunch the economy following COVID-19 pandemic and aims to improve the European Union on several levels including; making it greener, accelerating its digitalisation, improving the health system and preparing it for future challenges or supporting young people and making Europe more inclusive. The main project under this initiative is the Recovery and Resilience Facility (RRF) which provides grants and loan funding to EU member states to support reform and investment. In order to access these funds, each EU Member State must propose a plan which must be approved by the European Commission and then by the Council. One of the most important criteria of this plan is that at least 20% is dedicated to the green aspect and 37% to digitalisation. Disbursement is gradual, with 13% received after the contract is signed, and the remainder on the basis of a bi-annual evaluation based on a report submitted and a payment request.
https://en.wikipedia.org/wiki?curid=65789694
1,099,014
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The enriched environment argument is based on evidence that rats raised in complex environments perform better on maze tasks and have 20–25% more synaptic connections than those raised in austere environments. However, these enriched environments were in laboratory cages, and did not come close to replicating the intensely stimulating environment a rat would experience in the wild. Furthermore, the formation of these additional connections in response to novel environmental stimuli occurs throughout life, not just during a critical or sensitive period. For example, skilled pianists show enlarged representations in the auditory cortex relating specifically to piano tones, while violinists have enlarged neural representations for their left fingers. Even London taxi drivers who learn the London street map in intense detail develop enlarged formations in the part of the brain responsible for spatial representation and navigation. These results show that the brain can form extensive new connections as the result of focused educational input, even when this input is received solely during adulthood. Greenough's work suggests a second type of brain plasticity. Whereas synaptogenesis and critical periods relate to experience-expectant plasticity, synaptic growth in complex environments relates to "experience-dependent" plasticity. This type of plasticity is concerned with environment specific learning, and not to features of the environment that are ubiquitous and common to all members of the species, such as vocabulary.
https://en.wikipedia.org/wiki?curid=25935238
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Scientific investigation has not found any histological or physiological evidence for traditional Chinese concepts such as "qi", meridians, and acupuncture points, and many modern practitioners no longer support the existence of life force energy ("qi") or meridians, which was a major part of early belief systems. Acupuncture is believed to have originated around 100 BC in China, around the time "The Inner Classic of Huang Di" (Huangdi Neijing) was published, though some experts suggest it could have been practiced earlier. Over time, conflicting claims and belief systems emerged about the effect of lunar, celestial and earthly cycles, yin and yang energies, and a body's "rhythm" on the effectiveness of treatment. Acupuncture fluctuated in popularity in China due to changes in the country's political leadership and the preferential use of rationalism or scientific medicine. Acupuncture spread first to Korea in the 6th century AD, then to Japan through medical missionaries, and then to Europe, beginning with France. In the 20th century, as it spread to the United States and Western countries, spiritual elements of acupuncture that conflicted with scientific knowledge were sometimes abandoned in favor of simply tapping needles into acupuncture points.
https://en.wikipedia.org/wiki?curid=1537
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The research that appeared to spark an onslaught of modified applications was a gel permeation chromatography technique of fixing poly(isopropyl acrylate) (PIPA) strands to glass beads and separating a mixture of dextrans, which was developed by Gewehr et al. They found that between the temperatures of 25–32 °C, the elution time of dextrans at different molecular weights exhibited a dependence on the temperature. Dextrans of the highest molecular weight eluted first since the PIPA chains exhibit hydrophilicity at temperatures below the LCST. As the temperature of the elution increased, when the chains behave in a more hydrophobic manner, the elution times increased for each of the analytes for the given range. The trend generally applies over the entire temperature range, but there is a flattening of the curve before 25 °C and after 32 °C (the approximate LCST for this experiment). It is important to note that above the LCST, the PIPA acts as a typical nonpolar stationary phase that would be used in reverse-phased chromatography. There are also instances of the elution times increasing below 15 °C, which most likely can be attributed to the lower temperatures’ effects on mass transfer playing a more significant role on retention than the stationary phase behavior. This study showed that the resolution could essentially be tuned by adjusting the operating temperature. The scope of this study was limited to isothermal conditions and attaching polymer chains to glass beads. The results, however, were satisfying enough to inspire other investigations and modifications to create a more versatile stationary phase for the advancement of chromatography.
https://en.wikipedia.org/wiki?curid=37850414
2,175,296
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Painting roof materials in white or pale colors to reflect solar radiation, known as 'cool roof' technology, is encouraged by legislation in some areas (notably California). This technique is limited in its ultimate effectiveness by the constrained surface area available for treatment. This technique can give between 0.01 and 0.19 W/m of globally averaged negative forcing, depending on whether cities or all settlements are so treated. This is small relative to the 3.7 W/m of positive forcing from a doubling of atmospheric carbon dioxide. Moreover, while in small cases it can be achieved at little or no cost by simply selecting different materials, it can be costly if implemented on a larger scale. A 2009 Royal Society report states that, "the overall cost of a 'white roof method' covering an area of 1% of the land surface (about 10 m) would be about $300 billion/yr, making this one of the least effective and most expensive methods considered." However, it can reduce the need for air conditioning, which emits carbon dioxide and contributes to global warming.
https://en.wikipedia.org/wiki?curid=20694764
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Vladimir Markovnikov born in 1838, was a Russian Scientist who proceeded most of his work at Kazan University in Russia. In his time at the University he studied in a laboratory better known as "The Cradle of Russian Organic Chemistry". Butlerov was his teacher in his time at Kazan more or less a mentor in where he inherited lots of knowledge from which would contribute to his rule. In addition to his years at Kazan where he would graduate, he studied in Germany for two years expanding his knowledge of chemistry. Markovnikovs contributions to the fields of organic chemistry lead to his findings in his own rule in which he named after himself. The rule stated that hydrogen halides when added to alkenes and alkynes would add in a way that hydrogens would bond to the side of the carbon with the most hydrogen substituents. Products in chemistry that follow this rule were considered markvnikov and those that did not were considered anti-markovnikov products. In today's world this rule would be used to fuel what we call "green chemistry" or for lack of better terms atom efficiency where all the atoms in the reaction are being used as opposed to half or less. Markovnikov in a broader spectrum contributed to the region of regiochemistry or regioselectivity where atom substituents (mostly carbon) can be pre-determined based upon rules such as this. With his rule, Markovnikov revolutionized the areas of substition and elimination reactions with a better understanding of carbocation intermediates and transitions phases in a reaction. Because of these contributions in 1945 Alexander Erminingeldovich Arbuzov headed a branch of the chemistry department for the USSR at Kazan and it received an award based on the foundations of alumni Markovnikov. Even with his findings Markovnikovs rule was not the end all be all because there were found exceptions such as free radical addition and olefin metathesis. With his rule Markovnikov was able to contribute in the fields of petroleum products and alicylic compounds because they both contain needs for specified regioselectivity. Markovnikovs contributions were not brought out all by himself though. Names like Berichete, Michael, and Kharasch were major contributors allowing for Markovnikovs works to be published and seen around the world.
https://en.wikipedia.org/wiki?curid=1416046
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In 1876, Abbe was offered a partnership by Zeiss and began to share in the considerable profits. Although the first theoretical derivations of were published by others, it is fair to say that Abbe was the first to reach this conclusion experimentally. In 1878, he built the first homogenous immersion system for the microscope. The objectives that the Abbe Zeiss collaboration were producing were of ideal ray geometry, allowing Abbe to find that the aperture sets the upper limit of microscopic resolution, not the curvature and placement of the lenses. Abbe's first publication of occurred in 1882. In this publication, Abbe states that both his theoretical and experimental investigations confirmed . Abbe's contemporary Henry Edward Fripp, English translator of Abbe's and Helmholtz's papers, puts their contributions on equal footing. He also perfected the interference method by Fizeau, in 1884. Abbe, Zeiss, Zeiss' son, Roderich Zeiss, and Otto Schott formed, in 1884, the Jenaer Glaswerk Schott & Genossen. This company, which in time would in essence merge with Zeiss Optical Works, was responsible for research and production of 44 initial types of optical glass. Working with telescopes, he built an image reversal system in 1895.
https://en.wikipedia.org/wiki?curid=524981
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After the dissolution of the Society amid catastrophic hyperinflation in 1921, Webern obtained work as director not only of the , but also, from 1922 until the dissolution of these institutions after the failed February Uprising, of the mixed-voice amateur and the through his relationship with DJ Bach, Director of the . His performances in this capacity were aired on "Österreichischer Rundfunk" no fewer than twenty times starting in 1927. In 1933 he engaged Erich Leinsdorf as rehearsal and solo pianist for the , who later reflected on the experience as of "utmost value to my musical and critical development"; together they gave a performance of Stravinsky's dance cantata on folk idioms "Les Noces", of which the "popevki"-like 3-7A cell and its 4–10 variant are not altogether unlike the rhythmized trichords of Webern's Op. 24 from the following year (1934) or the Op. 30 tetrachords (which Stravinsky later admired) apart from Stravinsky's tendency to anhemitony in marked contrast to Webern's hemitonicism. In 1926, Webern noted his voluntary resignation as chorusmaster of the Mödling , a paid position, in controversy over his hiring of a Jewish singer, Greta Wilheim, to replace a sick one. Letters document their correspondence in many subsequent years, and she (among others) would in turn provide him with facilities to teach private lessons as a convenience to Webern, his family, and his students.
https://en.wikipedia.org/wiki?curid=65676
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The holotype (specimen used as the basis for the taxon) is the only known example of this genus and species, and was the first dinosaur ever found in Antarctica. It consists of three isolated teeth, part of the lower jaw with another tooth "in situ", some other skull fragments, vertebrae (neck, back, hips and tail), some partial limb bones (scapula, ilium and femur), toe bones (five metapodials and two phalanges), and numerous pieces of armor, representing approximately 15% of the skeleton. This specimen was initially located in January 1986 on James Ross Island, off the Antarctic Peninsula. It was discovered by Argentine geologists Eduardo Olivero and Roberto Scasso, but excavation was not completed for almost a decade due to the frozen ground and harsh weather conditions. The material was collected from an area of 6 square meters (64.5 sq ft) over several field seasons but is assumed to have belonged to a single individual. Much of the skeleton is in poor condition, as many of the bones nearest to the surface were subjected to years of fragmentation by freeze-thaw weathering.
https://en.wikipedia.org/wiki?curid=4583327
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A replication of Dunbar's analysis on updated complementary datasets using different comparative phylogenetic methods yielded wildly different numbers. Bayesian and generalized least-squares phylogenetic methods generated approximations of average group sizes between 69–109 and 16–42, respectively. However, enormous 95% confidence intervals (4–520 and 2–336, respectively) implied that specifying any one number is futile. The researchers drew the conclusion that a cognitive limit on human group size cannot be derived in this manner. The researchers also criticised the theory behind Dunbar's number because other primates' brains do not handle information exactly as human brains do, because primate sociality is primarily explained by other factors than the brain, such as what they eat and who their predators are, and because humans have a large variation in the size of their social networks. Dunbar commented the choice of data for this study, however, now stating that his number should not be calculated from data on primates or anthropoids, as in his original study, but on apes. This would mean that his cognitive limit would be based on 16 pair-living gibbon species, three solitary orangutans, and only four group living great apes (chimpanzees, bonobos and two gorilla species), which would not be sufficient for statistical analyses.
https://en.wikipedia.org/wiki?curid=2678638
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In 1996–97, the governance of the college was changed. Before the change, two bodies regulated college under Articles of Association and a Scheme of Management: a College Council of 12 teachers and 12 students elected by members of college, and a College Corporation of 16 members self-appointed. Council directed education and finance policy through its committees, and elected college officers: the Principal, Vice Principal, Dean of Studies, Bursar and Librarian. Corporation managed college charitable trust funds and provided for asset maintenance and part-finance for courses; it was composed largely of lawyers, bankers and businessmen thought capable of managing and extending charitable funding from the private sector. Both bodies and their officers were voluntary. Before 1996, an administrative staff of Warden, Deputy Warden, Financial Controller, and College Secretary ran the college day-to-day, managing a small number of part-time reception and maintenance staff. After legal advice, and representations to the Charity Commission, Corporation introduced a new Scheme of Management that dissolved Council, and created a self-appointed governing Board of 21 members to decide policy and oversee what became an enlarged paid management. Forceful argument on the change was made on both sides. Seeing Liberal Education's civic values and democratic control as being relevant was a view opposed by one that saw a more management-based method being needed for financial and educational viability.
https://en.wikipedia.org/wiki?curid=14165953
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The Coyote V8, first produced in 2010 for the 2011 model year, was an evolutionary (rather than revolutionary) development of Ford's Modular V8. Ford engineers needed to design a V8, specifically for the Mustang GT, that would compete with the GM 6.2L LS3 used in the new Chevrolet Camaro, and the new Chrysler 6.4L Hemi ESF in the Charger, Challenger, and Grand Cherokee. Since this engine replaced the already popular 4.6L and 5.4L Modular Engines, this engine had to remain close to the same physical size of the outgoing 4.6L, and share other specifications with it such as bore spacing, deck height, bell housing bolt pattern, etc. in order for the engine to utilize existing Modular production line tooling (the source of the 'Modular' designation for the engine family). The result was the 5.0L Coyote, which produced roughly the same amount of power as its competitors, but with a much smaller displacement. To strengthen the block enough to handle increased output, webbing was extensively used as reinforcement in the casting, rather than increasing the thickness of the walls. The intake plenum was also situated low between the two cylinder banks to meet the height constraint, thus the alternator traditionally placed low and center was moved to the side of the engine. It shares the 's bore spacing and deck height, while bore diameter and stroke have increased to , respectively. The engine also retains the 4.6 L's connecting rod length, which produces a 1.62:1 rod to stroke ratio. The firing order has been changed from that shared by all previous Modular V8s (1-3-7-2-6-5-4-8) to that of the Ford Flathead V8 (1-5-4-8-6-3-7-2). Compression ratio is 11.0:1, and despite having port fuel injection (as opposed to direct injection) the engine can still be run on 87 octane gasoline.
https://en.wikipedia.org/wiki?curid=867439
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