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In rare conditions it has the potential to lead to limited functional activity in the upper extremity to which it is adjacent. It can affect a person's ability to lift, pull, and push weighty objects. In some serious cases, the ability to perform activities of daily living such as changing one's clothes and washing one's hair may be hindered. The name of this condition comes from its appearance, a wing-like resemblance, due to the medial border of the scapula sticking straight out from the back. Scapular winging has been observed to disrupt scapulohumeral rhythm, contributing to decreased flexion and abduction of the upper extremity, as well as a loss in power and the source of considerable pain. A winged scapula is considered normal posture in young children, but not older children and adults.
https://en.wikipedia.org/wiki?curid=8665003
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Through the compilation and analysis of a database of nearly three dozen birds and reptiles, and comparison with existing data about the anatomy of "Coelophysis" Rinehart "et al." (2009) drew the following conclusions. It was estimated that average egg of "Coelophysis" was 31–33.5 millimeters across its minor diameter, and that each female would lay between 24 and 26 eggs in each clutch. The evidence suggested that some parental care was necessary to nurture the relatively small hatchlings during the first year of life, where they would reach 1.5 meters in length by the end of their first growth stage. "Coelophysis bauri" invested as much energy in reproduction as other extinct reptiles of its approximate size.
https://en.wikipedia.org/wiki?curid=1091927
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"The A.V. Club" gave it an A−, stating that "the mini-games are awesome, especially the batting challenge, which lets you get used to EA's "load and fire" batting system (which, we hear, was licensed from Club Jenna)". "The New York Times" gave it a favorable review and said: "The big news is a different online feature, ESPN Integration, which uses your network connection to run a live ESPN news ticker along the bottom of your screen as you play. This is a wonderfully ingenious way to increase the sense that you are experiencing an actual baseball game, and to keep sports aficionados satisfied". "Maxim", on the other hand, gave it a score of seven out of ten and stated that "after nine innings, it's basically the same game, including easy to master controls that'll finally allow you to be big man on campus. Or at least big man on LAN party". "USA Today" similarly gave it seven stars out of ten and said that the game "shows promise for the genre with its innovative take on batting. But a game that is as thrilling as a bunt could have been fun as a grand slam". "Detroit Free Press" gave it two stars out of four: "The game itself has decent game play, but is hurt because of the lack of attention given to the bells and whistles".
https://en.wikipedia.org/wiki?curid=3827069
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Purdue won the outright 2017 Big Ten Conference title, along with Caleb Swanigan being named unanimous B1G Player of the Year. In the 2017 NCAA Tournament, Purdue reached the Sweet Sixteen, losing to #1 seed Kansas. In the 2017–2018 season, Purdue, led by seniors Vince Edwards, Isaac Haas, PJ Thompson, Dakota Mathias and sophomore Carsen Edwards, spent several weeks at #3 while being on a program record and nation-leading 19-game winning streak. During that time, the Boilers led the nation in scoring margin, points per game, three-point shooting, and was one of only two teams with a top 3 ranking in both offensive and defensive efficiency. Purdue missed out on a consecutive B1G title after losing to Wisconsin, finishing 2nd in the conference at 15–3. The Boilers were seeded 4th in the Big Ten tournament, where they beat Rutgers and Penn State to reach the Big Ten tournament Championship for the second time in three years. They faced a familiar opponent in Michigan, whom they had already faced two other times throughout that season, Purdue winning both meetings. However, Michigan beat Purdue 75–66 to become Big Ten tournament Champions for the second straight season.
https://en.wikipedia.org/wiki?curid=8204961
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If "P"("N") stands for the proposition that there is an infinitude of pairs of prime numbers (not necessarily consecutive primes) that differ by exactly "N", then Zhang's result is equivalent to the statement that there exists at least one even integer "k" < 70,000,000 such that "P"("k") is true. The classical form of the twin prime conjecture is equivalent to "P"(2); and in fact it has been conjectured that "P"("k") holds for "all" even integers "k". While these stronger conjectures remain unproven, a result due to James Maynard in November 2013, employing a different technique, showed that "P"("k") holds for some "k" ≤ 600. Subsequently, in April 2014, the Polymath project 8 lowered the bound to "k" ≤ 246. With current methods "k" ≤ 6 is the best attainable, and in fact "k" ≤ 12 and "k" ≤ 6 follow using current methods if the Elliott–Halberstam conjecture and its generalization, respectively, hold.
https://en.wikipedia.org/wiki?curid=39441844
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The International Society for Environmental Epidemiology (ISEE) is a scientific society with membership drawn from more than 60 countries, dedicated to the study of environmental epidemiology and exposure assessment. It provides a forum for the discussion of problems unique to the study of health and the environment. The primary objective of ISEE is to promote research and disseminate scientific findings focused on the relationships between environmental exposures (e.g., air pollutants, food and water contaminants, metals, etc.) and human health. Each year, ISEE puts a spotlight on global discussion of environmental health and gathers scientists from all over the world to discuss measuring harmful factors in the environment including environmental health after disasters, e-waste, endocrine disrupting chemicals affecting pregnancy, and more. These include annual meetings, newsletters, workshops and liaisons with academic, governmental, inter-governmental, non-profit and business institutions.
https://en.wikipedia.org/wiki?curid=60457184
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Under Tory's guidance, the early years were marked by recruitment of professors and construction of the first campus buildings. Today, he has a building named after him that houses classes of all types. Percy Erskine Nobbs & Frank Darling designed the master plan for the University of Alberta in 1909–10. Nobbs designed the Arts Building (1914–15), laboratories and Power House (1914). With Cecil S. Burgess, Nobbs designed the Provincial College of Medicine (1920–21). Architect Herbert Alton Magoon designed several buildings on campus, including St. Stephen's Methodist College (1910) and the residence for professor Rupert C. Lodge (1913). The University of Alberta awarded its first degrees in 1912, the same year it established the Department of Extension. The Faculty of Medicine was established the following year and the Faculty of Agriculture began in 1915.
https://en.wikipedia.org/wiki?curid=242057
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Heisenberg stated the concept in many different ways in his work, for one example he wrote: "In this situation it follows automatically that, in a mathematical treatment of the process, a dividing line must be drawn between, on the one hand, the apparatus which we use as an aid in putting the question and thus, in a way, treat as part of ourselves, and on the other hand, the physical systems we wish to investigate. The latter we represent mathematically as a wave function. This function, according to quantum theory, consists of a differential equation which determines any future state from the present state of the function... The dividing line between the system to be observed and the measuring apparatus is immediately defined by the nature of the problem but it obviously signifies no discontinuity of the physical process. For this reason there must, within limits, exist complete freedom in choosing the position of the dividing line."
https://en.wikipedia.org/wiki?curid=37674773
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While Gropius was active at the Bauhaus, Ludwig Mies van der Rohe led the modernist architectural movement in Berlin. Inspired by the De Stijl movement in the Netherlands, he built clusters of concrete summer houses and proposed a project for a glass office tower. He became the vice president of the German Werkbund, and became the head of the Bauhaus from 1930 to 1933. proposing a wide variety of modernist plans for urban reconstruction. His most famous modernist work was the German pavilion for the 1929 international exposition in Barcelona. It was a work of pure modernism, with glass and concrete walls and clean, horizontal lines. Though it was only a temporary structure, and was torn down in 1930, it became, along with Le Corbusier's Villa Savoye, one of the best-known landmarks of modernist architecture. A reconstructed version now stands on the original site in Barcelona.
https://en.wikipedia.org/wiki?curid=315927
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To assist in this task, the Bentham papers at UCL are being digitised by crowdsourcing their transcription. Transcribe Bentham is a crowdsourced manuscript transcription project, run by University College London's Bentham Project, in partnership with UCL's UCL Centre for Digital Humanities, UCL Library Services, UCL Learning and Media Services, the University of London Computer Centre, and the online community. The project was launched in September 2010 and is making freely available, via a specially designed transcription interface, digital images of UCL's vast Bentham Papers collection—which runs to some 60,000 manuscript folios—to engage the public and recruit volunteers to help transcribe the material. Volunteer-produced transcripts will contribute to the Bentham Project's production of the new edition of "The Collected Works of Jeremy Bentham", and will be uploaded to UCL's digital Bentham Papers repository, widening access to the collection for all and ensuring its long-term preservation. Manuscripts can be viewed and transcribed by signing-up for a transcriber account at the Transcription Desk, via the Transcribe Bentham website.
https://en.wikipedia.org/wiki?curid=46038
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After revealing that Earth is no longer part of the United Federation of Planets in the third season, the writers knew that it would be a big moment for the series to have Earth rejoin the Federation and decided that this would be a two-season arc that concludes in the fourth-season finale. They wanted the season to explore ethical questions in a similar way to "" and "The Next Generation", to make "Discovery" feel more like traditional "Star Trek". The season also explores the mental health struggles of some characters, which was relevant to the creative team due to the real-world impacts of the pandemic. For Species 10-C, an unknown species that created the destructive anomaly, they wanted to create a species that was unlike any seen before in "Star Trek" or other science fiction franchises. They especially wanted the species to be difficult to communicate with, so the characters could not rely on their universal translators, and worked with science consultant Erin Macdonald as well as METI (Messaging to Extra-Terrestrial Intelligence) to understand what the new species could be.
https://en.wikipedia.org/wiki?curid=63388083
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Goat evolution is the process by which domestic goats came to exist through evolution by natural selection. Wild goats — medium-sized mammals which are found in noticeably harsh environments, particularly forests and mountains, in the Middle East and Central Asia — were one of the first species domesticated by modern humans, with the date of domestication generally considered to be 8,000 BCE. Goats are part of the family Bovidae, a broad and populous group which includes a variety of ruminants such as bison, cows and sheep. Bovids all share many traits, such as hooves and a herbivorous diet and all males, along with many females, have horns. Bovids began to diverge from deer and giraffids during the early Miocene epoch. The subfamily Caprinae, which includes goats, ibex and sheep, are considered to have diverged from the rest of Bovidae as early as the late Miocene, with the group reaching its greatest diversity in the ice ages.
https://en.wikipedia.org/wiki?curid=60746925
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Zhang "et al." hypothesize that, if survivin is a significant contributor to the development of hormonal therapy resistance in prostate cancer cells, targeting survivin and blocking it would enhance prostate cancer cell susceptibility to anti-androgen therapy. (Anti-androgen therapy uses drugs to eliminate the presence of androgens in the cell and cellular environment, since such androgens are known to enhance tumour immortality in prostate cancer cells.) Zhang "et al." first assessed the level of survivin expression of LNCaP (an androgen-dependent prostate cancer cell line that expresses intact androgen receptors) using quantitative Western analysis and found high expression of survivin in these cells. Cells exposed to dihydrotestosterone (DHT), an exogenous androgen, showed increased levels of survivin expression only and not other IAP family members. This result suggests that androgens may upregulate survivin, which contributes to the resistance to apoptosis observed in the tumour cells. Next, with the addition of flutamide (an antiandrogen) to the cells, survivin levels were observed to significantly decrease. The LNCaP cells were transduced separately with the different constructs of the survivin gene (mutant or wild-type) and subjected to flutamide treatment and assessed for the apoptosis level. Flutamide-treated survivin mutant-transduced cells were shown to significantly increase apoptosis by double that of flutamide treatment alone. On the other end, overexpression of the wild-type survivin was found to significantly reduce the apoptosis levels from flutamide treatment compared to flutamide treatment alone. Therefore, these results support the hypothesis that survivin plays a role in the anti-apoptotic nature of the LNCaP cancer cell line and that inhibiting survivin in prostate cancer cells appears to enhance the therapeutic effect of flutamide.
https://en.wikipedia.org/wiki?curid=8310787
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One subtle aspect of the role of economic intelligence is the interdependence of the continental and world economies. The economic health of Mexico clearly affects the United States, just as the Turkish economy is of concern to the European Community. In a post-Cold War environment, the roles of Russia and China are still evolving. Japan, with a history of blurred lines between industry and government, may regard a policy (for them) as perfectly ethical, which would be questionable in North America or Eastern Europe. New groupings such as the Shanghai Cooperative Organization are principally economic. Economic measures also may be used to pressure specific countries—for example, South Africa while it sustained a policy of apartheid, or Sudan while there is widespread persecution in Darfur.
https://en.wikipedia.org/wiki?curid=13979889
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Ambiophonics is a method in the public domain that employs digital signal processing (DSP) and two loudspeakers directly in front of the listener in order to improve reproduction of stereophonic and 5.1 surround sound for music, movies, and games in home theaters, gaming PCs, workstations, or studio monitoring applications. First implemented using mechanical means in 1986, today a number of hardware and VST plug-in makers offer Ambiophonic DSP. Ambiophonics eliminates crosstalk inherent in the conventional stereo triangle speaker placement, and thereby generates a speaker-binaural soundfield that emulates headphone-binaural sound, and creates for the listener improved perception of "reality" of recorded auditory scenes. A second speaker pair can be added in back in order to enable 360° surround sound reproduction. Additional surround speakers may be used for hall ambience, including height, if desired.
https://en.wikipedia.org/wiki?curid=15773993
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With the exception of Western Australia, the colonies also operated their own navies. In 1856, Victoria received its own naval vessel, HMCSS "Victoria", and its deployment to New Zealand in 1860 during the First Taranaki War marked the first occasion that an Australian warship had been deployed overseas. The colonial navies were expanded greatly in the mid-1880s and consisted of a number of gunboats and torpedo-boats for the defence of harbours and rivers, as well as naval brigades to man vessels and forts. Victoria became the most powerful of all the colonial navies, with the ironclad HMVS "Cerberus" in service from 1870, as well as the steam-sail warship on loan from the Royal Navy, three small gunboats and five torpedo-boats. New South Wales formed a Naval Brigade in 1863 and by the start of the 20th century had two small torpedo-boats and a corvette. The Queensland Maritime Defence Force was established in 1885, while South Australia operated a single ship, HMCS "Protector". Tasmania had also a small Torpedo Corps, while Western Australia's only naval defences included the Fremantle Naval Artillery. Naval personnel from New South Wales and Victoria took part in the suppression of the Boxer Rebellion in China in 1900, while HMCS "Protector" was sent by South Australia but saw no action. The separate colonies maintained control over their military and naval forces until Federation in 1901, when they were amalgamated and placed under the control of the new Commonwealth of Australia.
https://en.wikipedia.org/wiki?curid=1323516
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Myxobacteria are distinguished from most bacteria by their remarkable range of social behaviors, and as a result, multiple laboratories have taken up studies of these bacteria as a prokaryotic paradigm for differentiation processes and signal transduction. Most studies on social behavior in the myxobacteria have focused on "M. xanthus", which has provided an excellent system amenable to many classical genetic experimental approaches. The fruiting bodies of "M. xanthus" are relatively simple mounds, and the considerably more elaborate fruiting structures produced by "S. aurantiaca" has led to "S. aurantiaca" being considered an excellent complementary system to "M. xanthus", especially given the advent of contemporary means of genomic analysis. Most of the 95 known "M. xanthus" development-specific genes are highly conserved in "S. aurantiaca". Genes for entire signal transduction pathways important for fruiting body formation in "M. xanthus" are conserved in "S. aurantiaca", whereas only a few are conserved in "Anaeromyxobacter dehalogenans", a non-fruiting member of the order Myxococcales.
https://en.wikipedia.org/wiki?curid=34224939
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Tc, half-life 211k years, is produced at a yield of about 6% per fission; see also the main fission products page. It is also produced (via the short lived nuclear isomer Technetium-99m) as a decay product of Molybdenum-99. Technetium is particularly mobile in the environment as it forms negatively charged pertechnetate-ions and it presents the biggest radiological hazard among the long lived fission products. Despite being a metal, Technetium usually doesn't form positively charged ions, but Technetium halides like Technetium hexafluoride exist. TcF is a nuisance in uranium enrichment as its boiling point () is very close to that of uranium hexafluoride (). The issue is known to enrichment facilities because spontaneous fission also yields small amounts of Technetium (which will be in secular equilibrium with its parent nuclides in natural uranium) but if fluoride volatility is employed for reprocessing, a significant share of the "uranium" fraction of fractional distillation will be contaminated with Technetium requiring a further separation step.
https://en.wikipedia.org/wiki?curid=4364523
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Checklists have been used in medical practice to attempt to ensure that clinical practice guidelines are followed. An example is the Surgical Safety Checklist developed for the World Health Organization by Dr. Atul Gawande. According to a meta-analysis after introduction of the checklist mortality dropped by 23% and all complications by 40%, but further high-quality studies are required to make the meta-analysis more robust. In the UK, a study on the implementation of a checklist for provision of medical care to elderly patients admitting to hospital found that the checklist highlighted limitations with frailty assessment in acute care and motivated teams to review routine practices, but that work is needed to understand whether and how checklists can be embedded in complex multidisciplinary care.
https://en.wikipedia.org/wiki?curid=1294685
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The LHC was shut down on 13 February 2013 for its 2-year upgrade called Long Shutdown 1 (LS1), which was to touch on many aspects of the LHC: enabling collisions at 14 TeV, enhancing its detectors and pre-accelerators (the Proton Synchrotron and Super Proton Synchrotron), as well as replacing its ventilation system and of cabling impaired by high-energy collisions from its first run. The upgraded collider began its long start-up and testing process in June 2014, with the Proton Synchrotron Booster starting on 2 June 2014, the final interconnection between magnets completing and the Proton Synchrotron circulating particles on 18 June 2014, and the first section of the main LHC supermagnet system reaching operating temperature of , a few days later. Due to the slow progress with "training" the superconducting magnets, it was decided to start the second run with a lower energy of 6.5 TeV per beam, corresponding to a current of 11,000 amperes. The first of the main LHC magnets were reported to have been successfully trained by 9 December 2014, while training the other magnet sectors was finished in March 2015.
https://en.wikipedia.org/wiki?curid=357353
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Unlike peroxisomes, for most of the trypanosomes their glycosomes are needed for them to be able to survive. Because of this need for the glycosome, it has been suggested as a possible drug target to find a drug to halt its function. When the glycosome is not functioning correctly there is a severe lack of enzymes in the cell. These enzymes are those associated with ether-lipid synthesis or the beta oxidation of certain fatty acids. Cells without glycosomes are deficient in these enzymes as without the compartmentalization of the glycosome the enzymes are degraded in the cell in the cytosol. The organelle keeps metabolism of the enzymes from occurring. For parasites, ether-lipid synthesis is vital to be able to complete its life cycle, making the enzymes protected by the glycosome also vital. In their life cycle, glycolysis partly through the glycosome is very high in the blood stream form comparatively to the pro-cyclic form. The glycosomal glycolysis pathway is necessary in stress situations for the pathogen as glycolysis can be started when the substrates for the pathway are available even when ATP is not available yet. So as this organelle is so essential for the trypanosome, if a drug could target this organelle, it could be a successful therapy as studies have shown without the glycosome parasite death occurs.
https://en.wikipedia.org/wiki?curid=8631841
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Healthcare in America itself may deteriorate for certain communities due to such trends, particularly in terms of the lack of access to specialty services in rural locations. In particular, a September 2022 report from the University of Hawaiʻi System found that the collection of islands faces "a severe physician shortage". A piece published that same month by Spectrum News 1 - Ohio described the Midwestern state as featuring a shortage "that's expected to hit rural areas the hardest." Mechanisms of structural inequality in the U.S. affect its national health due to past and current discrimination, particularly efforts to set people apart based on Americans' racial identities.
https://en.wikipedia.org/wiki?curid=71941912
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Because of their exceptional contrast and fringe stability, interferometers using the Sagnac configuration played an important role in experiments leading to Einstein's discovery of special relativity, and in the subsequent defense of relativity against theoretical and experimental challenges. For example, one year before their famous experiment of 1887, Michelson and Morley (1886) performed a repeat of the Fizeau experiment of 1851, replacing Fizeau's setup with an even-reflection Sagnac interferometer of such high stability, that even placing a lighted match in the light path did not cause artifactual fringe displacement. In 1935, Gustaf Wilhelm Hammar disproved a theoretical challenge to special relativity that attempted to explain away the null results of Michelson–Morley–type experiments as being mere artifact of aether-dragging, using an odd-reflection Sagnac interferometer. He could operate this interferometer in the open, on a high hilltop with no temperature control, yet still achieve readings of 1/10 fringe accuracy.
https://en.wikipedia.org/wiki?curid=35152689
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Nepal was a late entrant into the modern world of science and technology. Nepal’s first institution of higher education, Tri-Chandra College, was established by Chandra Shumsher in 1918. The college introduced science at the intermediate level a year later, marking the genesis of formal science education in the country. However, the college was not accessible to the general public but only to a handful of members of the Rana regime. Throughout the Rana regime that lasted for well over a century, Nepal was effectively isolated from the rest of the world. Owing to this isolation, Nepal was relatively untouched by and unfamiliar of social transformations brought about by the British invasion in India and the Industrial Revolution in the West. However, after the advent of democracy and abolition of Rana regime in 1951, Nepal broke free from the shackles of self-imposed isolation and opened up to the outside world. This opening marked the initiation of science and technology activities in the country, with Tribhuvan University, the first of its kind in the country, soon coming into being in 1959. By 1965, the university offered postgraduate programs in natural sciences, namely physics, chemistry, zoology, and botany.
https://en.wikipedia.org/wiki?curid=52027146
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Sputtering relies on a plasma (usually a noble gas, such as argon) to knock material from a "target" a few atoms at a time. The target can be kept at a relatively low temperature, since the process is not one of evaporation, making this one of the most flexible deposition techniques. It is especially useful for compounds or mixtures, where different components would otherwise tend to evaporate at different rates. Note, sputtering's step coverage is more or less conformal. It is also widely used in optical media. The manufacturing of all formats of CD, DVD, and BD are done with the help of this technique. It is a fast technique and also it provides a good thickness control. Presently, nitrogen and oxygen gases are also being used in sputtering.
https://en.wikipedia.org/wiki?curid=1033036
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In 1987, the "Newtsuit" was developed by the Canadian engineer Phil Nuytten, and a version was put into production as the "Hardsuit" by Hardsuits International. The Newtsuit is constructed to function like a 'submarine you can wear', allowing the diver to work at normal atmospheric pressure even at depths of over . Made of wrought aluminium, it had fully articulated joints so the diver can move more easily underwater. The life support system provides 6–8 hours of air, with an emergency back-up supply of an additional 48 hours. The Hardsuit was used to salvage the bell from the wreck of the SS "Edmund Fitzgerald" in 1995. The latest version of the Hardsuit designed by Oceanworks, the "Quantum 2", uses higher power commercially available ROV thrusters for better reliability and more power as well as an atmospheric monitoring system to monitor the environmental conditions in the cabin.
https://en.wikipedia.org/wiki?curid=1273138
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Modern social anthropology was founded in Britain at the London School of Economics and Political Science following World War I. Influences include both the methodological revolution pioneered by Bronisław Malinowski's process-oriented fieldwork in the Trobriand Islands of Melanesia between 1915 and 1918 and Alfred Radcliffe-Brown's theoretical program for systematic comparison that was based on a conception of rigorous fieldwork and the structure-functionalist conception of Durkheim’s sociology. Other intellectual founders include W. H. R. Rivers and A. C. Haddon, whose orientation reflected the contemporary "Parapsychologies" of Wilhelm Wundt and Adolf Bastian, and Sir E. B. Tylor, who defined anthropology as a positivist science following Auguste Comte. Edmund Leach (1962) defined social anthropology as a kind of comparative micro-sociology based on intensive fieldwork studies. Scholars have not settled a theoretical orthodoxy on the nature of science and society, and their tensions reflect views which are seriously opposed.
https://en.wikipedia.org/wiki?curid=33661613
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The biggest though, by far, was a 4–3 victory over top-ranked Miami on January 18, 2015. Smiddy scored twice in the victory, including the opening goal and the game winner with 3:16 left. Saideh and O'Connor also scored goals that stalled the hosts' momentum at crucial points, while Tonetti offered 33 saves in one of the best performances of her career. Prior to the PSU win, the RedHawks had a 31-game unbeaten streak dating back 359 days, as well as a 25-game unbeaten streak at Goggin Ice Center. Additionally, MU had been the number one team in every ACHA Division 1 ranking issued since the beginning of the 2013–14 season (a streak that would last until that October) and had won the 2014 ACHA Division 1 title to initiate a run of three straight ACHA championship games (winning again in 2016).
https://en.wikipedia.org/wiki?curid=51386378
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Avi Silberschatz (born in Haifa, Israel) is an Israeli computer scientist and researcher. He graduated in 1976 with a Ph.D. in Computer Science from the State University of New York (SUNY) at Stony Brook. He became the Sidney J. Weinberg Professor of Computer Science at Yale University, USA in 2005. He was the chair of the Computer Science department at Yale from 2005 to 2011. Prior to coming to Yale in 2003, he was the Vice President of the Information Sciences Research Center at Bell Labs. He previously held an endowed professorship at the University of Texas at Austin, where he taught until 1993. His research interests include database systems, operating systems, storage systems, and network management. Silberschatz was elected an ACM Fellow in 1996 and received the Karl V. Karlstrom Outstanding Educator Award in 1998.
https://en.wikipedia.org/wiki?curid=4210106
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A similar highly advanced gas cooled reactor originally designed by West Germany (the AVR reactor) and now developed by South Africa is known as the Pebble Bed Modular Reactor. It is an inherently safe design, meaning that core damage is physically impossible, due to the design of the fuel (spherical graphite "pebbles" arranged in a bed within a metal RPV and filled with TRISO (or QUADRISO) pellets of uranium, thorium, or mixed oxide within). A prototype of a very similar type of reactor has been built by the Chinese, HTR-10, and has worked beyond researchers' expectations, leading the Chinese to announce plans to build a pair of follow-on, full-scale 250 MWe, inherently safe, power production reactors based on the same concept. (See Nuclear power in the People's Republic of China for more information.)
https://en.wikipedia.org/wiki?curid=162498
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A drilling jumbo consists of one, two or three rock drill carriages, sometimes a platform, which the miner stands on to load the holes with explosives, clear the face of the tunnel or do something else. The carriages are bolted onto the chassis, which supports also the miners cabin and of course the engine. Modern drilling jumbos are relatively large, there are however smaller ones for use in cramped conditions. Whereas modern jumbos usually fitted with rubber tyres and diesel-powered, there are also exist variants with steel wheels, to ride on rails and even single carriage sled-mounted ones. Electric power is also common, historic jumbos were powered by compressed air. Electricity and compressed air produce no exhaust gases, which is preferable if work is done in smaller tunnels where good ventilation is difficult.
https://en.wikipedia.org/wiki?curid=45204119
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The summer Boot Camp is a continuing national activity that provides an opportunity for teachers to visit Fermilab and see the accelerators and detectors for themselves. Teachers from existing QuarkNet centers attend Boot Camp and form research groups to explore experimental data. They apply the physics that they know (i.e., energy and momentum conservation) to unravel the physics encoded in the data. This helps the teachers construct new knowledge about what has transpired inside the detector in exactly the same way that experimenters do. Teachers work in separate groups investigating triggers released by CMS in early 2011. The groups search the data for evidence of the J/Psi, Z and W bosons. They used Excel to reconstruct the invariant mass of a particle when given the four-vector of that particle's decay products. In addition, participants attend several talks and go on tours of technical areas.
https://en.wikipedia.org/wiki?curid=9208413
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A study into exactly how a hadrosaur broke down and ate its food was conducted by Vince Williams, a graduate student at the University of Leicester; Paul Barrett, a paleontologist with London's Natural History Museum; and Mark Purnell, a British paleontologist from the geology department of the University of Leicester. The three men employed a new approach to analyze the feeding mechanisms of dinosaurs, and thus help understand their place in the prehistoric ecosystems. Chewing on solid food always leaves tiny scratches on the teeth's surfaces. The trio believed that by looking at the size and orientation of those markings on hadrosaurid teeth, they would be able to learn about the movements of their jaws. Purnell said although he believed this form of study could help determine how and what the hadrosaur ate, he said no previous studies had ever employed this type of analysis.
https://en.wikipedia.org/wiki?curid=23481302
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The Intel Pentium 4 was the first modern desktop processor to implement simultaneous multithreading, starting from the 3.06 GHz model released in 2002, and since introduced into a number of their processors. Intel calls the functionality Hyper-Threading Technology, and provides a basic two-thread SMT engine. Intel claims up to a 30% speed improvement compared against an otherwise identical, non-SMT Pentium 4. The performance improvement seen is very application-dependent; however, when running two programs that require full attention of the processor it can actually seem like one or both of the programs slows down slightly when Hyper-threading is turned on. This is due to the replay system of the Pentium 4 tying up valuable execution resources, increasing contention for resources such as bandwidth, caches, TLBs, re-order buffer entries, and equalizing the processor resources between the two programs which adds a varying amount of execution time. The Pentium 4 Prescott core gained a replay queue, which reduces execution time needed for the replay system. This was enough to completely overcome that performance hit.
https://en.wikipedia.org/wiki?curid=315021
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AR has been used for cockroach phobia treatment and to reduce the fear of spiders. Patients wearing augmented reality glasses can be reminded to take medications. Augmented reality can be very helpful in the medical field. It could be used to provide crucial information to a doctor or surgeon without having them take their eyes off the patient. On 30 April 2015 Microsoft announced the Microsoft HoloLens, their first attempt at augmented reality. The HoloLens has advanced through the years and is capable of projecting holograms for near infrared fluorescence based image guided surgery. As augmented reality advances, it finds increasing applications in healthcare. Augmented reality and similar computer based-utilities are being used to train medical professionals. In healthcare, AR can be used to provide guidance during diagnostic and therapeutic interventions e.g. during surgery. Magee et al. for instance describe the use of augmented reality for medical training in simulating ultrasound guided needle placement. A very recent study by Akçayır, Akçayır, Pektaş, and Ocak (2016) revealed that AR technology both improves university students' laboratory skills and helps them to build positive attitudes relating to physics laboratory work. Recently, augmented reality began seeing adoption in neurosurgery, a field that requires heavy amounts of imaging before procedures.
https://en.wikipedia.org/wiki?curid=85631
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In 1962, Woese spent several months as a visiting researcher at the Pasteur Institute in Paris, a locus of intense activity on the molecular biology of gene expression and gene regulation. While in Paris, he met Sol Spiegelman, who invited Woese to visit the University of Illinois after hearing his research goals; at this visit Spiegelman offered Woese a position with immediate tenure beginning in the fall of 1964. With the freedom to patiently pursue more speculative threads of inquiry outside the mainstream of biological research, Woese began to consider the genetic code in evolutionary terms, asking how the codon assignments and their translation into an amino acid sequence might have evolved.
https://en.wikipedia.org/wiki?curid=40598
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A photovoltaic cell is a specialized semiconductor diode that converts light into direct current (DC) electricity. Depending on the band gap of the light-absorbing material, photovoltaic cells can also convert low-energy, infrared (IR) or high-energy, ultraviolet (UV) photons into DC electricity. A common characteristic of both the small molecules and polymers (Fig. 3) used as the light-absorbing material in photovoltaics is that they all have large conjugated systems. A conjugated system is formed where carbon atoms covalently bond with alternating single and double bonds. These hydrocarbons' electrons pz orbitals delocalize and form a delocalized bonding π orbital with a π* antibonding orbital. The delocalized π orbital is the highest occupied molecular orbital (HOMO), and the π* orbital is the lowest unoccupied molecular orbital (LUMO). In organic semiconductor physics, the HOMO takes the role of the valence band while the LUMO serves as the conduction band. The energy separation between the HOMO and LUMO energy levels is considered the band gap of organic electronic materials and is typically in the range of 1–4 eV.
https://en.wikipedia.org/wiki?curid=18397250
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These termites live underground, and their presence is often undetected. Winged reproductives (alates) appear above ground in the late winter or spring. When this happens inside a house, this may alert the homeowner to the fact that the termites are present. After a short flight, the insects shed their wings, and a female will search for a crevice or other suitable underground nesting site and be joined there by a male. Having mated and excavated a chamber, the female (queen) starts laying eggs. The first batch of eggs hatch into larvae which develop into workers; these enlarge the nest, search for food and carry it back to the nest. As the number of termites in the colony increases, some workers further develop into soldiers; in well-established colonies, there may be hundreds of thousands of individual insects. Alates are not produced until the colony has been established for several years. In large colonies, it is possible for workers to develop into non-winged reproductives which lay eggs to supplement the queen's effort, or which can replace her should she die.
https://en.wikipedia.org/wiki?curid=61244047
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Maraging steel's strength and malleability in the pre-aged stage allows it to be formed into thinner rocket and missile skins than other steels, reducing weight for a given strength. Maraging steels have very stable properties and, even after overaging due to excessive temperature, only soften slightly. These alloys retain their properties at mildly elevated operating temperatures and have maximum service temperatures of over . They are suitable for engine components, such as crankshafts and gears, and the firing pins of automatic weapons that cycle from hot to cool repeatedly while under substantial load. Their uniform expansion and easy machinability before aging make maraging steel useful in high-wear components of assembly lines and dies. Other ultra-high-strength steels, such as AerMet alloys, are not as machinable because of their carbide content.
https://en.wikipedia.org/wiki?curid=1359497
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The AN/AAQ-13 navigation pod contains a terrain-following radar which allows the pilot to safely fly at a very low altitude following cues displayed on a HUD; it also can be coupled to the autopilot to provide "hands off" terrain-following capability. This pod also contains a forward-looking infrared system which is projected on the HUD, typically used during nighttime or low-visibility operations. The nav pod is installed beneath the right engine intake. The targeting pod contains a laser designator and a tracking system that mark an enemy for destruction as far away as 10 mi (16 km). Once tracking has started, targeting information is automatically handed off to infrared homing air-to-surface missiles or laser-guided bombs. The targeting pod is mounted beneath the left engine intake; configurations may be either the AN/AAQ-14 Target Pod, AN/AAQ-28 LITENING Target Pod, or the AN/AAQ-33 Sniper Advanced Targeting Pod.
https://en.wikipedia.org/wiki?curid=495724
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Specimens have historically been able to live up to nearly 300 years, but in modern stressed conditions, 100 years is more typical. A number of defoliating insects threaten the tree; in the late 20th century, western spruce budworm epidemics killed sizable populations of grand fir in the eastern Cascades and Blue Mountains. The lack of an ability to use pitch to patch wounds, including those from logging and small fires, provides a weakness exploited by rot fungi. East of the Cascade ridge, grand fir trunks are infected by Indian paint fungus, indicating a rotten core; such specimens are often waterlogged and thus crack apart in freezing weather.
https://en.wikipedia.org/wiki?curid=1238041
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The smooth-bore musket was the main weapon of the line infantry and light infantry, and rifles were used only by snipers and other specialist troops. All muskets were supplied with bayonets, which allowed them to be used in melee combat. At the time, the Russian and French armies actively used light infantry (rangers and voltigeurs), and sometimes scattered whole infantry battalions as skirmishers to fight long-term on rough terrain. Although rifles had better shooting accuracy than smoothbore muskets, their effective fire range was the same. For example, in the British Army, light infantrymen armed with ordinary muskets were trained for 300–400 yards. Since they were used as pikes, muskets tended to be fairly long and heavy weapons. They tended to be about four to six feet in length (six to eight feet including the bayonet), with a weight of around , as longer and heavier weapons were found to be too unwieldy. The length of a musket also allowed them to be fired by ranks, minimizing the risk that the men in the rear ranks would accidentally shoot the men in the front ranks in the back of the head, or, more likely, scorch their faces and burst their eardrums with the muzzle blast. Muskets six feet in length could be fired in three ranks without fear of accidents.
https://en.wikipedia.org/wiki?curid=1868350
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Immediately after its foundation, publication of the Society's journal Anales SEFQ commenced. This was the fundamental and almost exclusive means of communication that members were entitled to, which provided an annual end-of-year report, or ‘Memoria’. These reports, along with the minutes of the monthly meetings, are the best guide to the eventful history of the Society. The ‘Memoria’ submitted by the first Board in 1903, which ceased in its functions on 3-XII-1904, reported that the number of papers published in Anales SEFQ in that year was 57, ‘a number that illustrates this country’s growing interest in this genre of studies’, and that the Society's membership in the first year was 263, with a fee of 15 pesetas per year. These membership fees provided the Society's financial support, complemented by a few sporadic donations and charges for advertisements until, in 1911, the Ministry of Public Instruction granted a yearly assignment of 3,000 pesetas, which by 1935 had increased to 13,252 pesetas from the Public Instruction Ministry and 9,500 pesetas from the Ministry of State. By then, membership had reached 1,400 and the annual membership fee had risen to 25 pesetas.
https://en.wikipedia.org/wiki?curid=60132162
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From 2001 to 2007, Majerus carried out experiments in Cambridge to resolve the various criticisms of Kettlewell's experiment. During his experiment, he noted the natural resting positions of peppered moths. Of the 135 moths examined, over half were on tree branches, mostly on the lower half of the branch; 37% were on tree trunks, mostly on the north side; and only 12.6% were resting on or under twigs. Following correspondence with Hooper, he added an experiment to find if bats, not birds, could be the main predators. He observed a number of species of bird actually preying on the moths, and found that differential bird predation was a major factor responsible for the decline in "carbonaria" frequency compared to "typica". He described his results as a complete vindication of the natural selection theory of peppered moth evolution, and said "If the rise and fall of the peppered moth is one of the most visually impacting and easily understood examples of Darwinian evolution in action, it should be taught. It provides after all the proof of evolution."
https://en.wikipedia.org/wiki?curid=628768
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Measurements of Δ can be used to better understand the physiology of extinct organisms, and to place constraints on the early development of endothermy, the process by which organisms regulate their internal body temperatures. Prior to the development of clumped isotope analysis, there was no straightforward way to estimate either the body temperature or body water δO of extinct animals. Eagle et al., 2010 measure Δ47 in bioapatite from a modern Indian elephant, white rhinoceros, Nile crocodile and American alligator. These animals were chosen as they span a wide range in internal body temperatures, allowing for the creation of a mathematical framework relating Δ of bioapatite and internal body temperature. This relationship has been applied to analyses of fossil teeth, in order to predict the body temperatures of a woolly mammoth and a sauropod dinosaur. The latest Δ temperature calibration for (bio)apatite of Löffler et al. 2019 covers a wide temperature range of 1 to 80 °C and was applied to a fossil megalodon shark tooth for calculating seawater temperatures and δO values.
https://en.wikipedia.org/wiki?curid=48750239
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The Australian Commonwealth Military Forces came into being on 1 March 1901 and all the colonial forces—including those still in South Africa—became part of the new force. 28,923 colonial soldiers, including 1,457 professional soldiers, 18,603 paid militia and 8,863 unpaid volunteers, were subsequently transferred. The individual units continued to be administered under the various colonial Acts until the "Defence Act 1903" brought all the units under one piece of legislation. This Act also prevented the raising of standing infantry units and specified that militia forces could not be used in industrial disputes or serve outside Australia. However, the majority of soldiers remained in militia units, known as the Citizen Military Forces (CMF). Major General Sir Edward Hutton—a former commander of the New South Wales Military Forces—subsequently became the first commander of the Commonwealth Military Forces on 26 December and set to work devising an integrated structure for the new army. In 1911, following a report by Lord Kitchener the Royal Military College, Duntroon was established, as was a system of universal National Service.
https://en.wikipedia.org/wiki?curid=1323516
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Late in 1917, Fokker built the experimental V 11 biplane, fitted with the standard Mercedes D.IIIa engine. In January 1918, "Idflieg" held a fighter competition at Adlershof. For the first time, front line pilots participated in the evaluation and selection of new fighters. Fokker submitted the V 11 along with several other prototypes. Manfred von Richthofen flew the V 11 and found it tricky, unpleasant and directionally unstable in a dive. Platz lengthened the rear fuselage by one structural bay and added a triangular fin in front of the rudder. Richthofen tested the modified V 11 and praised it as the best aircraft of the competition. It offered excellent performance from the outdated Mercedes engine, yet was safe and easy to fly. Richthofen's recommendation virtually decided the competition, but he was not alone in recommending it. Fokker immediately received a provisional order for 400 production aircraft, which were named D.VII by "Idflieg".
https://en.wikipedia.org/wiki?curid=160632
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Carlsen made headlines after his victory, at the age of 13, in the C group at the 2004 Corus chess tournament in Wijk aan Zee. He obtained a score of 10½/13, losing just one game (against the highest-rated player of the C group, Duško Pavasovič). As a result, he earned his first GM norm, and achieved a of 2702. Particularly notable was his win over Sipke Ernst in the penultimate round, when he sacrificed material to give mate in just 29 moves. His victory in the C group qualified him to play in the B group in 2005, and it led Lubomir Kavalek, writing for the "Washington Post", to give him the title "the Mozart of chess" (although, as pointed out by Edward Winter, the nickname had been given to many illustrious predecessors). Agdestein said that Carlsen had an excellent memory and played an unusually wide range of openings. Carlsen's prowess caught the attention of Microsoft, which became his sponsor.
https://en.wikipedia.org/wiki?curid=442682
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Crick began a PhD research project on measuring the viscosity of water at high temperatures (which he later described as "the dullest problem imaginable") in the laboratory of physicist Edward Neville da Costa Andrade at University College London, but with the outbreak of World War II (in particular, an incident during the Battle of Britain when a bomb fell through the roof of the laboratory and destroyed his experimental apparatus), Crick was deflected from a possible career in physics. During his second year as a PhD student, however, he was awarded the Carey Foster Research Prize, a great honour. He did postdoctoral work at the Brooklyn Collegiate and Polytechnic Institute.
https://en.wikipedia.org/wiki?curid=11461
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Alberts then worked with Paul M. Doty on "enormously ambitious" PhD thesis projects, first attempting to solve the genetic code using nearest neighbor analysis after treatment of DNA with various mutagens, and then trying to test his theoretical model for how DNA polymerase could replicate a double-helical DNA template. After failing his first oral examination in spring 1965, he completed his Ph.D. research in fall 1965. His doctorate in biophysics was finally awarded by Harvard University in 1966. Alberts credits his initial failure with teaching him much more than his successes. "That was a very important learning experience for me. I had decided that experimental strategy was everything in science, and nobody had ever told me anything about this."
https://en.wikipedia.org/wiki?curid=2067987
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During the 20th century, Harvard's international reputation for scholarship grew as a burgeoning endowment and prominent professors expanded the university's scope. Explosive growth in the student population continued with the addition of new graduate schools and the expansion of the undergraduate program. It built the largest and finest academic library in the world and built up the labs and clinics needed to establish the reputation of its science departments and the Medical School. The Law School vied with Yale Law for preeminence, while the Business School combined a large-scale research program with a special appeal to entrepreneurs rather than accountants. The different schools maintain their separate endowments, which are very large in the case of the college/Faculty of Arts and Sciences, and the Business, Law and Medical Schools, but quite modest for the Divinity and Education schools.
https://en.wikipedia.org/wiki?curid=4484508
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CMR uses the same basic principles of image acquisition and reconstruction as other MRI techniques. Imaging of the cardiovascular system is usually performed with cardiac gating using an adaptation of conventional ECG techniques. Cine sequences of the heart are acquired using balanced steady state free precession (bSSFP) which has good temporal resolution and intrinsic image contrast. T1-weighted sequences are used to visualize anatomy and detect the presence of intra-myocardial fat. T1 mapping has also been developed to quantify diffuse myocardial fibrosis. T2-weighted imaging is mainly used to detect myocardial edema which may develop in acute myocarditis or infarction. Phase-contrast imaging uses bipolar gradients to encode velocity in a given direction and is used to assess valve disease and quantify shunts.
https://en.wikipedia.org/wiki?curid=13791336
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In January 1837 Cooke proposed a design for a 60-code mechanical telegraph to the directors of the Liverpool and Manchester Railway. This was too complicated for their purposes; the immediate need was for a simple signal communication between the Liverpool station and a rope-haulage engine house at the top of a steep incline through a long tunnel outside the station. Rope-haulage into main stations was common at this time to avoid noise and pollution, and in this case the gradient was too steep for the locomotive to ascend unaided. All that was required were a few simple signals such as an indication to the engine house to start hauling. Cooke was requested to build a simpler version with fewer codes, which he did by the end of April 1837. However, the railway decided to use instead a pneumatic telegraph equipped with whistles. Soon after this Cooke went into partnership with Wheatstone.
https://en.wikipedia.org/wiki?curid=19446492
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The Vanderbilt University School of Medicine (abbreviated VUSM) was founded in 1851 as the school of medicine at the University of Nashville and only became affiliated with Vanderbilt University in 1874. The first degrees issued by Vanderbilt University were to 61 Doctors of Medicine in February 1875, thanks to an arrangement that recognized the University of Nashville's medical school as serving both institutions. The arrangement continued for 20 more years, until the school was reorganized under the control of the Vanderbilt Board of Trustees. In the early days, the School of Medicine was owned and operated as a private property of the practicing physicians who composed the faculty and received the fees paid by students. At this time, the course of medical instruction consisted of just three years of schooling, which was extended to four years starting in 1898. Vanderbilt University made no financial contribution to the school's support and exercised no control over admission requirements, the curriculum, or standards for graduation. In 1925, the school moved from the old South Campus across town to the main campus, thus integrating instruction in the medical sciences with the rest of the university.
https://en.wikipedia.org/wiki?curid=13893187
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The JP-2 genotype - also known as SIB-1, a subpopulation of A1 with a IIa mitochondrial haplotype - was found here by Akino et al 2010, and is genetically close to European populations. It is shared with Japan, China, and Korea. TH-1 (in the Ia mtDNA haplotype, of the A2 mating type) is shared with southwest China and Nepal, as reported for samples from 1994-1997 by Guo et al 2010. The US-1 population - a subtype of A1 in the Ib mt haplotype - is shared with China, India, Nepal, Japan, Taiwan, and Vietnam. It is first known in Asia from a Thai sample from 1981, but not reported until Saville and Ristaino 2020. A2 was unknown here until a restriction fragment length polymorphism (TH-1) was found in a 1994 sample by Gotoh et al 2005. Other samples from the same year from Chiang Mai, analysed by Nishimura et al 1999, showed both A1 (specifically US-1) and A2 (specifically a metalaxyl-sensitive genotype) on potato, but only US-1 on tomato. Twenty-five samples from 2000-2002 were found (by Petchaboon et al 2014) to have RG57s that matched European populations of the IIa mtDNA haplotype, of the A1 mating type - another two being other A1s. They used Day et al 2004's nomenclature for this almost universal potato parasite lineage, calling it RF006. This result was confirmed by a pers. comm. from employees of Agriculture Victoria in 2020, who know it as the simple sequence repeat genotype EU 8 A1 from samples they have from 2009 from Thailand. This is probably the same lineage that was found in 2006-2009 samples and reported by Jaimasit and Prakob in 2010 - 117 of them all being A1, IIa. Their samples were mostly metalaxyl-sensitive but with some -intermediate and some -resistant.
https://en.wikipedia.org/wiki?curid=3467679
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The behaviour of early "Homo", including "H. habilis", is sometimes modelled on that of savanna chimps and baboons. These communities consist of several males (as opposed to a harem society) in order to defend the group on the dangerous and exposed habitat, sometimes engaging in a group display of throwing sticks and stones against enemies and predators. The left foot OH 8 seems to have been bitten off by a crocodile, possibly "Crocodylus anthropophagus", and the leg OH 35, which either belongs to "P. boisei" or "H. habilis", shows evidence of leopard predation. "H. habilis" and contemporary hominins were likely predated upon by other large carnivores of the time, such as (in Olduvai Gorge) the hunting hyena "Chasmaporthetes nitidula", and the saber-toothed cats "Dinofelis" and "Megantereon". In 1993, American palaeoanthropologist Leslie C. Aiello and British evolutionary psychologist Robin Dunbar estimated that "H. habilis" group size ranged from 70–85 members—on the upper end of chimp and baboon group size—based on trends seen in neocortex size and group size in modern non-human primates.
https://en.wikipedia.org/wiki?curid=14348
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The introduction of a multiparty system in 1994 has resulted in a stable democratic government for the past two decades. This makes the country an increasingly reassuring destination for foreign investors. The government has recently begun reforming its financial management system and has put a series of fiscal incentives in place to attract foreign investors. The country has also introduced a series of policy instruments to promote FDI, including tax incentives and the Malawi Innovation Challenge Fund for private businesses, which nurtures productive partnerships between leading firms and poor producers and entrepreneurs. The need for research and services is enormous, in a country where 93% of the population still lacks access to electricity, 47% improved sanitation and one in four adults lacks any form of family planning.
https://en.wikipedia.org/wiki?curid=53472612
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In June 2007 UNESCO proclaimed Ciudad Universitaria of the Universidad Nacional Autónoma de México (UNAM), in Mexico City, a World Heritage Site due to its relevance and contribution in terms of international style movement. It was designed in the late 1940s and built in the mid-1950s based upon a masterplan created by architect Enrique del Moral. His original idea was enriched by other students, teachers, and diverse professionals of several disciplines. The university houses murals by Diego Rivera, Juan O'Gorman and others. The university also features Olympic Stadium (1968). In his first years of practice, Pritzker Prize winner and Mexican architect Luis Barragán designed buildings in the International Style. But later he evolved to a more traditional local architecture. Other notable Mexican architects of the International Style or modern period are Carlos Obregón Santacilia, Augusto H. Alvarez, Mario Pani, , Vladimir Kaspé, Enrique del Moral, Juan Sordo Madaleno, Max Cetto, among many others.
https://en.wikipedia.org/wiki?curid=314881
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The reputation and history of Damascus steel has given rise to many legends, such as the ability to cut through a rifle barrel or to cut a hair falling across the blade, though the accuracy of these legends is not reflected by the extant examples of patterned crucible steel swords which are often tempered in such a way as to retain a bend after being flexed past their elastic limit. A research team in Germany published a report in 2006 revealing nanowires and carbon nanotubes in a blade forged from Damascus steel, although John Verhoeven of Iowa State University in Ames, suggests the research team which reported nanowires in crucible steel was seeing cementite, which can itself exist as rods, so there might not be any carbon nanotubes in the rod-like structure. Although many types of modern steel outperform ancient Damascus alloys, chemical reactions in the production process made the blades extraordinary for their time, as Damascus steel was superplastic and very hard at the same time. During the smelting process to obtain Wootz steel ingots, woody biomass and leaves are known to have been used as carburizing additives along with certain specific types of iron rich in microalloying elements. These ingots would then be further forged and worked into Damascus steel blades. Research now shows that carbon nanotubes can be derived from plant fibers, suggesting how the nanotubes were formed in the steel. Some experts expect to discover such nanotubes in more relics as they are analyzed more closely. Wootz was also mentioned to have been made out of a co-fusion process using "shaburqan " (hard steel, likely white cast iron) and "narmahan" (soft steel) by Biruni, both of which were forms of either high and low carbon bloomery iron, or low carbon bloom with cast iron. In such a crucible recipe, no added plant material is necessary to provide the required carbon content, and as such any nanowires of cementite or carbon nanotubes would not have been the result of plant fibres.
https://en.wikipedia.org/wiki?curid=8593
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Real-time databases are traditional databases that use an extension to give the additional power to yield reliable responses. They use timing constraints that represent a certain range of values for which the data are valid. This range is called temporal validity. A conventional database cannot work under these circumstances because the inconsistencies between the real world objects and the data that represents them are too severe for simple modifications. An effective system needs to be able to handle time-sensitive queries, return only temporally valid data, and support priority scheduling. To enter the data in the records, often a sensor or an input device monitors the state of the physical system and updates the database with new information to reflect the physical system more accurately. When designing a real-time database system, one should consider how to represent valid time, how facts are associated with real-time system. Also, consider how to represent attribute values in the database so that process transactions and data consistency have no violations.
https://en.wikipedia.org/wiki?curid=8446344
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To correctly remove atmospheric disturbance, both emission and absorption, the airborne radiometers are calibrated for every measurement by SST measurements in multiple bands and/or under different angles. Atmospheric correction is only viable if the measured surface is not covered in clouds as they significantly disturb the emitted radiation. Clouds are either removed as viable pixels in the image using cloud busting algorithms or clouds are handled using histogram and spatial coherency techniques (up to 80% cloud cover). Radiometry captures the surface skin temperature (~10 micron depth) of the ocean, which significantly differs from bulk SST in-situ measurements. Phenomena close but not at the surface like diurnal thermocline formation are not well captured with satellites but SST can still be of tremendous value in oceanography. Overall satellites measure the SST with a ~0.1-0.6 K accuracy dependent on the sensor and only experience limited issues like surface slicks.
https://en.wikipedia.org/wiki?curid=67696353
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Additionally, drugs that affect monoamine transmission vary in their selectivity. For example, drugs with high selectivity for increasing dopamine and norepinephrine transmission relative to serotonin transmission tend to have highly addictive properties. Amphetamine and cocaine share this selectivity profile, and administration of these drugs generally results in a left-shift in M50 and θ indicating sensitization of the reward circuitry and high abuse potential. This characteristic leftward-shift of M50 in response to a moderate dose of cocaine is illustrated in a hypothetical data set in Figure 1. Note that the maximum response rate is reached at a lower frequency than it is at baseline, and there is a significant response rate at the lowest frequency, which did not produce responding under baseline conditions. Even following chronic administration of methamphetamine or cocaine, there is little to no tolerance to ICSS facilitation. After chronic treatment is stopped, however, there is a withdrawal-induced depression of ICSS responding, which can be reversed by re-administering the drug.
https://en.wikipedia.org/wiki?curid=6226648
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The 870 features a bottom-loading, side ejecting receiver and a tubular magazine under the barrel. The gun comes with a plug for migratory bird hunting which reduces the magazine's capacity to two rounds. It has dual action bars, internal hammer, and a bolt which locks into an extension in the barrel. The action, receiver, fire control group, safety catch and slide release catch of the Remington Model 870 shotgun are similar to those used on the Remington Model 7600 series pump-action centerfire rifles and carbines. The basic fire control group design was first used in the automatic 11–48.<ref name="Remington Model 870 (M870) Combat / Game Pump Action Shotgun August 7, 2014"></ref> Twelve gauge stocks will also interchange on the older 12-gauge-sized 20-gauge receivers, although modification is needed to fit the smaller sized 20-gauge receivers employed since the late 1970s. Several parts of the 870, such as buttstocks and magazine tubes, will interchange with the semi-automatic Remington 1100 and 11–87.
https://en.wikipedia.org/wiki?curid=1043933
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The final match between Hikaru Nakamura and Ian Nepomniachtchi for the championship was a memorable affair that went down to an Armageddon game. In the first game of the match Nepomniachtchi fell into time trouble and got tangled in difficult complications, which Nakamura exploited for a convincing win. The second game ended in a draw by repetition, though Nakamura could have pressed his advantageous position. Nepomniachtchi came back with a brilliant sacrificial win in the third game to even the match after Nakamura neglected king safety for too long. The players agreed to a quick draw in the fourth game and went to an Armageddon tiebreak to determine the championship. Nepomniachtchi bid 13 minutes and thus gained draw odds with the black pieces. The Russian grandmaster held the advantage early on and missed a winning chance. Nakamura rebounded with sharp play to create activity for his pieces and then won material on the way to the decisive win and the world championship title. The third, fifth and seventh place matches all ended in 3-1 scorelines. Magnus Carlsen took third place by winning three straight games against Nodirbek Abdusattorov after dropping the first game of the match. Vladimir Fedoseev beat Wesley So for fifth place and Matthias Blübaum defeated local favorite Hjorvar Steinn Gretarsson for seventh place.
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While preparing for the burn the crew was told that the S-IVB had impacted the Moon as planned, leading Lovell to quip, "Well, at least something worked on this flight." Kranz's White team of mission controllers, who had spent most of their time supporting other teams and developing the procedures urgently needed to get the astronauts home, took their consoles for the PC+2 procedure. Normally, the accuracy of such a burn could be assured by checking the alignment Lovell had transferred to the LM's computer against the position of one of the stars astronauts used for navigation, but the light glinting off the many pieces of debris accompanying the spacecraft made that impractical. The astronauts used the one star available whose position could not be obscured – the Sun. Houston also informed them that the Moon would be centered in the commander's window of the LM as they made the burn, which was almost perfectless than 0.3 meters (1 foot) per second off. The burn, at 79:27:38.95, lasted four minutes and 23 seconds. The crew then shut down most LM systems to conserve consumables.
https://en.wikipedia.org/wiki?curid=1770
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In the 1960s, it was predicted that as a white dwarf cools, its material should crystallize, starting at the center. When a star pulsates, observing its pulsations gives information about its structure. BPM 37093 was first observed to be a pulsating variable in 1992, and in 1995 it was pointed out that this yielded a potential test of the crystallization theory. In 2004, Antonio Kanaan and a team of researchers of the Whole Earth Telescope estimated, on the basis of these asteroseismological observations, that approximately 90% of the mass of BPM 37093 had crystallized. Other work gives a crystallized mass fraction of between 32% and 82%. Any of these estimates would result in a total crystalline mass in excess of 5 kilograms. As the white dwarf has a radius of , this means that the core of BPM 37093, nicknamed "Lucy", is likely one of the largest diamonds in the local region of the universe.
https://en.wikipedia.org/wiki?curid=469673
1,300,989
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The discovery's significance lay not only in Selam's antiquity, but also in her age at death. Although relatively complete infant skeletons have been recovered for more recent human species, not a single juvenile skeleton has been found for any of the species in the preceding millions of years. Most of these early finds consist of nothing more than a skull, a piece of jaw or some isolated teeth. In contrast to these relatively sparse finds, not only was the DRP team able to recover Selam's complete skull, but also a sandstone impression of her brain and even the hyoid bone. Due to the fragility of the hyoid, such a discovery in a species of Selam's antiquity is almost completely unprecedented. The team was able to recover a significant portion of Selam's bones below the neck as well, including most of the spinal column, the ribs, both collar bones and both shoulder blades. These bones are almost completely absent in the fossil record, except for fragmentary pieces from Lucy. Both knee caps and large portions of the thigh and shin bones from each leg were recovered, as well as an almost complete foot.
https://en.wikipedia.org/wiki?curid=7098772
1,326,638
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In the course of his fifty-two years editorship of the "Annalen" Poggendorff could not fail to acquire an unusual acquaintance with the labors of modern men of science. This knowledge, joined to what he had gathered by historical reading of equally unusual extent, he carefully digested and gave to the world in his "Biographisch-literarisches Handworterbuch zur Geschichte der exacten Wissenschaften", containing notices of the lives and labors of mathematicians, astronomers, physicists, and chemists, of all peoples and all ages. This work contains an astounding collection of facts invaluable to the scientific biographer and historian. The first two volumes were published in 1863; after his death a third volume appeared in 1898, covering the period 1858-1883, and a fourth in 1904, coming down to the beginning of the 20th century.
https://en.wikipedia.org/wiki?curid=475627
1,980,162
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Excisional biopsies may remove the tumor, but further surgery is often necessary to reduce the risk of recurrence. Complete surgical excision with adequate surgical margins and assessment for the presence of detectable metastatic disease along with short- and long-term followup is standard. Often this is done by a wide local excision (WLE) with margins. Melanoma-in-situ and lentigo malignas are treated with narrower surgical margins, usually . Many surgeons consider the standard of care for standard excision of melanoma-in-situ, but margin might be acceptable for margin controlled surgery (Mohs surgery, or the double-bladed technique with margin control). The wide excision aims to reduce the rate of tumor recurrence at the site of the original lesion. This is a common pattern of treatment failure in melanoma. Considerable research has aimed to elucidate appropriate margins for excision with a general trend toward less aggressive treatment during the last decades. A 2009 meta-analysis of randomized controlled trials found a small difference in survival rates favoring wide excision of primary cutaneous melanomas, but these results were not statistically significant.
https://en.wikipedia.org/wiki?curid=716631
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The first socialist government of Canada and one of the most influential came to power in the province of Saskatchewan in 1944. The Co-operative Commonwealth Federation of Tommy Douglas won an overwhelming victory toppling the age old Liberal regime which had dominated Saskatchewan politics since the founding of the province in 1905. Douglas and the CCF won five consecutive electoral victories. During his time in office he created the Saskatchewan Power Corporation which extended electricity services to the many rural villages and farms who before did without, created Canada's first public automobile insurance agency, created a substantial number of Crown Corporations (government and public owned businesses) many of which still exist today in Saskatchewan, allowed the unionisation of the public service, created the first system of Universal Health Care in Canada (which would later be adopted nationally in 1965), and created the Saskatchewan Bill of Rights, the first such charter in Canada. This preceded the Canadian Charter of Rights and Freedoms as well as the previous Canadian Bill of Rights.
https://en.wikipedia.org/wiki?curid=47246185
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DLSS is associated with behavioural problems depending on how much the disease affects the dog; in other words, the more tissue and bone that is affected by DLSS, the more reluctant the dog will be to perform any kind of physical activity. Its most general overview and research ground for understanding this pathological disease takes place in the military, since dogs who take part in the special forces (German and Dutch Shepherd, Labrador Retriever and Belgian Malinois being the most proper breeds) are widely studied as they progress through their incredibly active life. Those affected by DLSS, generally diagnosed in their retirement period, show a wide range of decreased activity when performing certain demanding tasks that require physical stress, thus, becoming crucial exemplars for lumbar diseases.
https://en.wikipedia.org/wiki?curid=62555402
1,846,405
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The Pfizer–BioNTech COVID-19 vaccine (INN: tozinameran), sold under the brand name Comirnaty, is an mRNA-based COVID-19 vaccine developed by the German biotechnology company BioNTech. For its development, BioNTech collaborated with American company Pfizer to carry out clinical trials, logistics, and manufacturing. It is authorized for use in people aged five years and older in some jurisdictions, twelve years and older in some jurisdictions, and for people sixteen years and older in other jurisdictions, to provide protection against COVID-19, caused by infection with the SARS-CoV-2 virus. The vaccine is given by intramuscular injection. It is composed of nucleoside-modified mRNA (modRNA) encoding a mutated form of the full-length spike protein of SARS-CoV-2, which is encapsulated in lipid nanoparticles. Initial advice indicated that vaccination required two doses given 21 days apart, but the interval was later extended to up to 42 days in the US, and up to four months in Canada.
https://en.wikipedia.org/wiki?curid=65797150
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For instance, printers were represented as a "file" at a known location when data was copied to the file, it printed out. Other systems, to provide a similar functionality, tended to virtualize devices at a lower level that is, both devices "and" files would be instances of some lower level concept. Virtualizing the system at the file level allowed users to manipulate the entire system using their existing file management utilities and concepts, dramatically simplifying operation. As an extension of the same paradigm, Unix allows programmers to manipulate files using a series of small programs, using the concept of pipes, which allowed users to complete operations in stages, feeding a file through a chain of single-purpose tools. Although the end result was the same, using smaller programs in this way dramatically increased flexibility as well as ease of development and use, allowing the user to modify their workflow by adding or removing a program from the chain.
https://en.wikipedia.org/wiki?curid=21346982
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In the 1960s, technological developments in the industries of aircraft, automotive, industrial control, and electronics provided advancements in the fields of three-dimensional surface construction, NC programming, and design analysis. Most of these developments were independent of one another and often not published until much later. Some of the mathematical description work on curves was developed in the early 1940s by Robert Issac Newton. In his 1957 novel "The Door into Summer", Robert A. Heinlein hinted at the possibility of a robotic "Drafting Dan". However, more substantial work on polynomial curves and sculptured surface was done by mathematician Paul de Casteljau from Citroen; Pierre Bézier from Renault; Steven Anson Coons from MIT; James Ferguson from Boeing; Carl de Boor, George David Birkhoff and Garibedian from GM in the 1960s; and W. Gordon and R. Riesenfeld from GM in the 1970s.
https://en.wikipedia.org/wiki?curid=60037798
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At the end of the century, the members of the French Academy of Sciences had attained clear dominance in the field. At the same time, the experimental tradition established by Galileo and his followers persisted. The Royal Society and the French Academy of Sciences were major centers for the performance and reporting of experimental work. Experiments in mechanics, optics, magnetism, static electricity, chemistry, and physiology were not clearly distinguished from each other during the 18th century, but significant differences in explanatory schemes and, thus, experiment design were emerging. Chemical experimenters, for instance, defied attempts to enforce a scheme of abstract Newtonian forces onto chemical affiliations, and instead focused on the isolation and classification of chemical substances and reactions.
https://en.wikipedia.org/wiki?curid=13758
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Apart from aluminium-lithium alloys and titanium alloys, carbon-fibre composite materials are used in the construction of the Tejas. The composite materials constitute 45% of the airframe by weight and 90% by surface area, the highest among contemporary aircraft. The upper and lower wing surfaces, wing spars and wing ribs are also made out of carbon-fibre composites, while the fin tip is made out of glass-fibre. The extensive use of composite materials in the airframe not only makes the aircraft lighter but also gives high strength. This also reduces the number of joints or rivets, increases the aircraft's structural integrity and lowers its susceptibility to fatigue cracks. The tailfin is a monolithic honeycomb structure, reducing the manufacturing cost by 80% compared to traditional methods. Initially the Tejas prototypes were equipped with a radome made out of Kevlar which was replaced with a quartz radome in the production aircraft.
https://en.wikipedia.org/wiki?curid=749967
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Time preference is a key component of the Austrian School of economics, it is used to understand the relationship between saving, investment and interest rates. According to the Misesian branch of the school: In acting, an actor invariably aims to substitute a more satisfactory for a less satisfactory state of affairs and thus demonstrates a preference for more rather than fewer goods. Moreover, he invariably consider when in the future his goals will be reached, i.e., the time necessary to accomplish them, as well as a good's duration of serviceability. Thus, he also demonstrates a universal preference for earlier over later goods, and for more over less durable ones. This is the phenomenon of time preference. Every actor requires some amount of time to attain his goal, and since man must always consume something and cannot entirely stop consuming while he is alive, time is always scarce. Thus, ceteris paribus, present or earlier goods are, and must invariably be, valued more highly than future or later ones. In fact, if man were not constrained by time preference and if the only constraint operating on him were that of preferring more over less, he would invariably choose those production processes which yielded the largest output per input, regardless of the length of time needed for these methods to bear fruit.
https://en.wikipedia.org/wiki?curid=253980
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Mutations in "NF1" are primarily associated with neurofibromatosis type 1 (NF1, also known as von Recklinghausen syndrome). NF1 is the most common single gene disorder in humans, occurring in about 1 in 2500-3000 births worldwide. NF1 is an autosomal dominant disorder, but approximately half of NF1 cases arise from "de novo" mutations. NF1 has high phenotypic variability, with members of the same family with the same mutation displaying different symptoms and symptom intensities. Café-au-lait spots are the most common sign of NF1, but other symptoms include lisch nodules of iris, cutaneous neurofibromas (CNF), plexiform neurofibromas (PN), skeletal defects, optic nerve gliomas, life-threatening malignant peripheral nerve sheath tumors (MPNST), attention deficits, learning deficits and other cognitive disabilities.
https://en.wikipedia.org/wiki?curid=6752005
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In November 2012, in a conference in Kyoto researchers said evidence gathered since July was falling into line with the basic Standard Model more than its alternatives, with a range of results for several interactions matching that theory's predictions. Physicist Matt Strassler highlighted "considerable" evidence that the new particle is not a pseudoscalar negative parity particle (consistent with this required finding for a Higgs boson), "evaporation" or lack of increased significance for previous hints of non-Standard Model findings, expected Standard Model interactions with W and Z bosons, absence of "significant new implications" for or against supersymmetry, and in general no significant deviations to date from the results expected of a Standard Model Higgs boson. However some kinds of extensions to the Standard Model would also show very similar results; so commentators noted that based on other particles that are still being understood long after their discovery, it may take years to be sure, and decades to fully understand the particle that has been found.
https://en.wikipedia.org/wiki?curid=20556903
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Despite these obstacles to their synthesis, a 2013 study published by a group of Russian physicists led by Valeriy Zagrebaev proposes that the longest-lived copernicium isotopes may occur at an abundance of 10 relative to lead, whereby they may be detectable in cosmic rays. Similarly, in a 2013 experiment, a group of Russian physicists led by Aleksandr Bagulya reported the possible observation of three cosmogenic superheavy nuclei in olivine crystals in meteorites. The atomic number of these nuclei was estimated to be between 105 and 130, with one nucleus likely constrained between 113 and 129, and their lifetimes were estimated to be at least 3,000 years. Although this observation has yet to be confirmed in independent studies, it strongly suggests the existence of the island of stability, and is consistent with theoretical calculations of half-lives of these nuclides.
https://en.wikipedia.org/wiki?curid=66394
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Continuous auditing is a set of processes that assess various aspects of information gathered in an audit in order to classify areas of risk and potential weaknesses in financial Internal controls at a more frequent rate than traditional methods. Instead of analyzing recorded transactions and journal entries on a periodic basis, continuous auditing focuses on interpreting the character of these actions more frequently. The frequency of these processes being undertaken as well as highlighting areas of importance is up to the discretion of their implementer, who commonly makes such decisions based on level of risk in the accounts being evaluated and the goals of implementing the system. Performance of these processes can occur as frequently as being nearly instantaneous with an entry being posted.
https://en.wikipedia.org/wiki?curid=70362483
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The LCS is reconfigured for various roles by changing mission packages, each of which includes mission module equipment (weapon systems, sensors, etc.), carried craft and mission crews. Modules include Anti-submarine warfare (ASW), mine countermeasures (MCM), surface warfare (SUW), and special warfare missions. The MCM and SUW modules are planned to reach initial operating capability in Fiscal year 2014, and the ASW module in FY2016. Module changes were envisioned to allow a single LCS to change roles in a matter of hours at any commercial port allowing it to rapidly optimize effectiveness against a threat. A report from the Office of the Chief of Naval Operations (OPNAV) on a January 2012 sustainment wargame reportedly stated that, possibly for logistics reasons, the mission module changes may take as long as weeks, and that in the future the navy plans to use LCS ships with a single module, with module changes being a rare occurrence. In 2014, "Independence" switched from mine to surface warfare modes in 96 hours on short notice.
https://en.wikipedia.org/wiki?curid=460005
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The family moved to Rhyl when John was two, and he attended Rhyl Grammar School where he discovered his interest in science. He continued his education at Jesus College, Oxford, gaining a BA in 1951, MA (Oxon) and DPhil in 1955. He was brought up as an evangelical Christian by devout Christian parents and believed in science and Christianity as strengthening each other, as well as Christianity and environmentalism. Houghton's evangelical Christianity combined with his scientific background made him a significant voice in evangelical Christian circles. He was a supporter of and advisor to the international Christian relief and development agency Tearfund. He was also an elder at Aberdovey Presbyterian Church. In 1962, Houghton married Dr Margaret Broughton, daughter of a mill owner in Colwyn, Lancashire, and they had two children and seven grandchildren. Following her death from cancer in 1986, he set up the Margaret Houghton Memorial Fund, a research unit on medical nursing in her memory. His second wife, Sheila, became his companion for almost thirty years.
https://en.wikipedia.org/wiki?curid=1070206
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Commentators were disappointed with the incoherent user interface provided by the software platform, with "Logistix looking like a PC, First Word slavishly copying GEM" and "101 other 'user interfaces'" amongst the early offerings. The result was the lack of a "personality" for the machine which risked becoming a system that would "never look as easy or as slick as the Mac". Alongside the introduction of visual and behavioural consistency between applications, personal computer user environments had also evolved from running a single application at a time, moved beyond "desk accessories" (or pop-up programs), normalised the practice of switching between applications, and had begun to provide the ability to run different applications at the same time, with the Macintosh having already done so with its MultiFinder enhancement. Computer Concepts, having begun development of various new applications for the Archimedes, was sufficiently frustrated with Arthur and its lack of "true multi-tasking" that it announced a rival operating system, Impulse, intended to host those applications on the machine.
https://en.wikipedia.org/wiki?curid=63145
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The 509th Composite Group was constituted on 9 December 1944, and activated on 17 December 1944, at Wendover Army Air Field, Utah. It was commanded by Lieutenant Colonel Paul W. Tibbets, who received promotion to full colonel in January 1945. It was initially assumed that the group would divide in two, with half going to Europe and half to the Pacific. In the first week of September Tibbets was assigned to organize a combat group to develop the means of delivering an atomic weapon by airplane against targets in Germany and Japan, then command it in combat. Because the organization developed by Tibbets was self-sustained, with flying squadrons of both Boeing B-29 Superfortress bombers and transport aircraft, the group was designated as a "composite" rather than a "bombardment" unit.
https://en.wikipedia.org/wiki?curid=4567536
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At the "temenos", the grave of Opheltes was surrounded by open-air altars and enclosed within a stone wall. The sanctuary's necessary spring was named Adrasteia: Pausanias wondered whether it had the name because an "Adrastos" had "discovered" it, but Adrasteia, the "inescapable one", was a nurse of the infant Zeus in Crete. The tumulus nearby was credited as the burial mound of his father, and the men of Argos had the privilege of naming the priest of Nemean Zeus, Pausanias was informed when he visited in the late 2nd century CE. In his time the temple, which he noted was "worth seeing", stood in a grove of cypresses; its roof had fallen in and there was no cult image within the temple. Three limestone columns of the Temple of Nemean Zeus of about 330 BC have stood since their construction, and two more were reconstructed in 2002. As of late 2007, four more are being re-erected. Three orders of architecture were employed at this temple, which stands at the end of the Classic period and presages this and other developments of Hellenistic architecture, such as the slenderness (a height of 6.34 column diameters) of the Doric columns of the exterior. The site around the temple has been excavated in annual campaigns since 1973: the great open-air altar, baths, and ancient accommodations for visitors have been unearthed. The temple stands on the site of an Archaic period temple, of which only a foundation wall is still visible. The stadion has recently been discovered. It is notable for its well-preserved vaulted entrance tunnel, dated to about 320 BC, with ancient graffiti on the walls.
https://en.wikipedia.org/wiki?curid=856535
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AdK plays a central role in controlling the cellular levels of Ado, which via its interaction with adenosine receptors in mammalian tissues produces a broad range of physiological responses including potent cardioprotective and neuroprotective activities. The overexpression of AdK in the brain, which leads to decreased Ado levels and loss of inhibition of neuronal excitability by astrocytes, has been proposed as the main underlying cause of progression of epilepsy. Hence, the modulation of AdK by external means provides an important strategy for harnessing its potential therapeutic benefits. As such, there is much interest in developing specific inhibitors of AdK. Many AdK inhibitors, some of which show useful analgesic, anti-seizure, and anti-inflammatory properties in animal models have been described.
https://en.wikipedia.org/wiki?curid=14676583
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Clonus (i.e. involuntary, rhythmic, muscular contractions and relaxations) tends to co-exist with spasticity in many cases of stroke and spinal cord injury likely due to their common physiological origins. Some consider clonus as simply an extended outcome of spasticity. Although closely linked, clonus is not seen in all patients with spasticity. Clonus tends to not be present with spasticity in patients with significantly increased muscle tone, as the muscles are constantly active and therefore not engaging in the characteristic on/off cycle of clonus. Clonus results due to an increased motor neuron excitation (decreased action potential threshold) and is common in muscles with long conduction delays, such as the long reflex tracts found in distal muscle groups. Clonus is commonly seen in the ankle but may exist in other distal structures as well, such as the knee or spine.
https://en.wikipedia.org/wiki?curid=98998
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Bryson attended Glenbard North High School and graduated in 1982. She studied Behavioural Science at the University of Chicago, graduating with an AB in 1986. In 1991 she moved to the University of Edinburgh where she completed an MSc in Artificial Intelligence before an MPhil in Psychology. Bryson moved to MIT to complete her PhD, earning a doctorate under Lynn Andrea Stein in 2001 for her thesis "Intelligence by Design: Principles of Modularity and Coordination for Engineering Complex Adaptive Agents". In 1995 she worked for LEGO Digital as an AI consultant with Kristinn R. Thórisson on cognitive architectures for autonomous LEGO characters in the Wizard Group. She completed a postdoctoral fellowship in Marc Hauser's Primate Cognitive Neuroscience at the Harvard University in 2002.
https://en.wikipedia.org/wiki?curid=56397386
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The molars of "Epicoyn haydeni" were grindstone-like teeth that allow for a canid diet that includes both meat and plant and insects. The proportional size of an animal's molars is a great measure of the nutritional diversity of its diet. Based on fossilized feces and its robust teeth and jaw muscles it is believed to have consumed large amounts of bone and share a similar digestive tract to modern day hyenas due to their ability to break down bones. They are also believed to be social hunters since "Epicyon hayden"i is very prevalent in the fossil record as one of the most common meat-eaters in North America during the late Miocene Epoch period. The deadly bite of a "Epicyon haydeni" was delivered by the canine teeth, which are placed near the front of the upper and lower jaws, the shortening of the jaws can be an effective method for getting the canines closer to the mandibular condyle, thereby increasing the biting force.
https://en.wikipedia.org/wiki?curid=4735044
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Formal methods are a particular kind of mathematically based technique for the specification, development and verification of software and hardware systems. The use of formal methods for software and hardware design is motivated by the expectation that, as in other engineering disciplines, performing appropriate mathematical analysis can contribute to the reliability and robustness of a design. They form an important theoretical underpinning for software engineering, especially where safety or security is involved. Formal methods are a useful adjunct to software testing since they help avoid errors and can also give a framework for testing. For industrial use, tool support is required. However, the high cost of using formal methods means that they are usually only used in the development of high-integrity and life-critical systems, where safety or security is of utmost importance. Formal methods are best described as the application of a fairly broad variety of theoretical computer science fundamentals, in particular logic calculi, formal languages, automata theory, and program semantics, but also type systems and algebraic data types to problems in software and hardware specification and verification.
https://en.wikipedia.org/wiki?curid=5323
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However, the choice of instruction set architecture may greatly affect the complexity of implementing high-performance devices. The prominent strategy, used to develop the first RISC processors, was to simplify instructions to a minimum of individual semantic complexity combined with high encoding regularity and simplicity. Such uniform instructions were easily fetched, decoded and executed in a pipelined fashion and a simple strategy to reduce the number of logic levels in order to reach high operating frequencies; instruction cache-memories compensated for the higher operating frequency and inherently low code density while large register sets were used to factor out as much of the (slow) memory accesses as possible.
https://en.wikipedia.org/wiki?curid=1410175
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Traditional instruments provided only the measurement of single events or event pairs. The introduction of the improved statistical tool of overlapping measurements by J. J. Snyder allowed much improved resolution in frequency readouts, breaking the traditional digits/time-base balance. While such methods is useful for their intended purpose, using such smoothed measurements for Allan variance calculations would give a false impression of high resolution, but for longer "τ" the effect is gradually removed, and the lower-"τ" region of the measurement has biased values. This bias is providing lower values than it should, so it is an overoptimistic (assuming that low numbers is what one wishes) bias, reducing the usability of the measurement rather than improving it. Such smart algorithms can usually be disabled or otherwise circumvented by using time-stamp mode, which is much preferred if available.
https://en.wikipedia.org/wiki?curid=40708
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MMI's emphasis from the beginning on the education portion of its mission led to a steady stream of outside experts through the institute, including the visiting professor program, established in 1973 and renamed in 1981 as a living memorial to the late Dr. Turner Alfrey, Jr. Each year, a leading scientist is invited to teach a short course, visit sponsoring organizations and deliver additional research seminars, benefitting many people by providing a point of connection between local scientists and engineers with the world leaders of the polymer science field.
https://en.wikipedia.org/wiki?curid=24131391
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Studies have indicated a connection between phenomena related to negligible senescence and the dynamic stability of an organism's underlying regulatory network over its lifetime. Depending on the parameters of metabolism and the connectivity of the network, on one hand, and the genetic and expressome error elimination rates (repair efficiency), on the other, organisms may function in such a way that damage is either effectively eliminated and kept under control at all times, or the amount of damage is getting exponentially amplified. The two limiting cases may correspond to the distinct regimes of non-aging and "normal" aging, respectively. The boundary between the aging regimes corresponds to the phase transition line, whereas most regulatory networks of living species operate at the stability-instability boundary. If the relation between aging and criticality in genetic regulatory networks and the corresponding explanation behind the negligible senescence is confirmed by further research, it may explain how weak genetic perturbation can produce switching between normal (Gompertzian) aging and negligibly senescent regimes on evolutional time scales.
https://en.wikipedia.org/wiki?curid=23003393
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Dan Gardner argues that Ehrlich has been insufficiently forthright in acknowledging errors he made, while being intellectually dishonest or evasive in taking credit for things he claims he got "right". For example, he rarely acknowledges the mistakes he made in predicting material shortages, massive death tolls from starvation (as many as one billion in the publication "Age of Affluence") or regarding the disastrous effects on specific countries. Meanwhile, he is happy to claim credit for "predicting" the increase of AIDS or global warming. However, in the case of disease, Ehrlich had predicted the increase of a disease based on overcrowding, or the weakened immune systems of starving people, so it is "a stretch to see this as forecasting the emergence of AIDS in the 1980s." Similarly, global warming was one of the scenarios that Ehrlich described, so claiming credit for it, while disavowing responsibility for failed scenarios is a double standard. Gardner believes that Ehrlich is displaying classical signs of cognitive dissonance, and that his failure to acknowledge obvious errors of his own judgement render his current thinking suspect.
https://en.wikipedia.org/wiki?curid=359542
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In late 1992 (Monday 14 September) the British pound began a steep decline that made it "leave" the Exchange Rate Mechanism on the Wednesday of that week. At the same time the Swedish currency began to decline; the first reaction from the central bank was to try to keep the current fixed exchange rates in place, and they set a target for their equivalent to the federal funds rate ("marginal rate") at 500%. The bank began to sell short-term government securities in large amounts but soon realized that market forces were strong, so they lowered their target rate, and let everyone sell what they wanted to sell, and the country saw a large selling of SEK, and SEK denominated papers. Between September 1992 and February 1993 the Swedish currency "TCW" index went from 125 to 100 (20% fall), while the British currency XBP index fell from 200 to 142 (29% fall).
https://en.wikipedia.org/wiki?curid=214951
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However, "Psittacosaurus" may not have been entirely bipedal for its entire lifespan. Taking sections from the limb bones of 16 specimens of "Psittacosaurus", ranging in age from less than a year old to ten-year-old adults, Qi Zhao from the University of Bristol found that "Psittacosaurus" was probably secondarily bipedal. The infants' front limbs grew at faster rates than the hind limbs at between birth and three years of age. At the age of between four and six years, arm growth slowed and leg growth accelerated as the animal became mature. At this stage, "Psittacosaurs" would switch to a bipedal stance. These findings further reveal that the ancestor of "Psittacosaurus" was likely quadrupedal and eventually gained the ability to become bipedal as it evolved, with the young retaining the quadrupedal gait of the ancestor in question. These findings also lead to the hypothesis that many such dinosaur families may have evolved along this path at some point in their evolution.
https://en.wikipedia.org/wiki?curid=2274247
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During the university's last years, the "Albertina" faculty and the German Student Union after the territorial separation of the Province of East Prussia by the Treaty of Versailles stressed its affiliation with the Reich, pushing intellectual life towards German nationalism. On 10 July 1944, the university celebrated its 400th anniversary in presence of Reich Minister Walther Funk. A few weeks later, during the nights of 26/27 and 29/30 August, Königsberg was extensively bombed by the Royal Air Force. From January to April 1945 the city was further devastated by the East Prussian Offensive of the Red Army and the final Battle of Königsberg. When General Otto Lasch signed the capitulation on April 9, the historic inner city was destroyed by the attacks, and 80% of the university campus lay in ruins. The faculty had fled, many of them were received at the University of Göttingen.
https://en.wikipedia.org/wiki?curid=670971
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The first commercial steam-powered device was a water pump, developed in 1698 by Thomas Savery. It used condensing steam to create a vacuum which raised water from below and then used steam pressure to raise it higher. Small engines were effective though larger models were problematic. They had a very limited lift height and were prone to boiler explosions. Savery's engine was used in mines, pumping stations and supplying water to water wheels powering textile machinery. Savery's engine was of low cost. Bento de Moura Portugal introduced an improvement of Savery's construction "to render it capable of working itself", as described by John Smeaton in the Philosophical Transactions published in 1751. It continued to be manufactured until the late 18th century. At least one engine was still known to be operating in 1820.
https://en.wikipedia.org/wiki?curid=27692
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