doc_id
int32
18
2.25M
text
stringlengths
245
2.96k
source
stringlengths
38
44
__index_level_0__
int64
18
2.25M
695,560
As laser science needed good theoretical foundations, and also because research into these soon proved very fruitful, interest in quantum optics rose. Following the work of Dirac in quantum field theory, George Sudarshan, Roy J. Glauber, and Leonard Mandel applied quantum theory to the electromagnetic field in the 1950s and 1960s to gain a more detailed understanding of photodetection and the statistics of light (see degree of coherence). This led to the introduction of the coherent state as a quantum description of laser light and the realization that some states of light could not be described with classical waves. In 1977, Kimble et al. demonstrated the first source of light which required a quantum description: a single atom that emitted one photon at a time. Another quantum state of light with certain advantages over any classical state, squeezed light, was soon proposed. At the same time, development of short and ultrashort laser pulses—created by Q-switching and mode-locking techniques—opened the way to the study of unimaginably fast ("ultrafast") processes. Applications for solid state research (e.g. Raman spectroscopy) were found, and mechanical forces of light on matter were studied. The latter led to levitating and positioning clouds of atoms or even small biological samples in an optical trap or optical tweezers by laser beam. This, along with Doppler cooling was the crucial technology needed to achieve the celebrated Bose–Einstein condensation.
https://en.wikipedia.org/wiki?curid=2627738
695,196
2,012,707
The Hoyas went 3–1 in their next four games, winning rematches with St. John's and at Providence, suffering an upset loss at Seton Hall, and defeating Villanova. The Hoyas had a balanced attack against the Red Storm, with Greg Whittington finishing with a team-high 12 points, Jason Clark, Otto Porter, and Markel Starks each scoring 11, Hollis Thompson adding 10 and Henry Sims nine, and Nate Lubick having an excellent all-around game with seven points, eight rebounds, five assists, and a career-high four blocked shots. The Hoyas, still the second-stingiest defensive team in the Big East (allowing 58.9 points per game), held Providence to 25.9 percent shooting from the field, the fourth time in five games they had held an opponent to making fewer than 35 percent of its shots, and moved into sole possession of third place in the conference standings by defeating the Friars; Hollis Thompson had a double-double against the Friars with 13 points and 10 rebounds, while Jason Clark also scored 13 and Henry Sims added 10. Allowing only 38.4 percent shooting overall and 27.6 in three-pointers by opponents on the season entering the Seton Hall game, Georgetown had its worst defensive performance of the year, allowing the Pirates to shoot 61.0 percent overall and 61.5 percent from three-point range; Greg Whittington's nine points led the Hoyas in the first game of the season in which no Georgetown player scored in double digits. The Hoyas recovered on both defense and offense against Villanova, limiting the Wildcats to 28 percent shooting from the field and outrebounding them 43–25 in a win that moved the Hoyas into sole possession of fourth place in the Big East; four Hoyas scored in double digits against the Wildcats, with Jason Clark and Otto Porter each finishing with 15, Henry Sims with 12, and Hollis Thompson with 10 points. The Hoyas rose to No. 10 in the AP Poll after beating St. John's and to No. 9 after the win at Providence, although the loss at Seton Hall prompted a drop to No. 11 after the Villanova game.
https://en.wikipedia.org/wiki?curid=33673923
2,011,550
778,187
The same individual geese on which we conducted these experiments, first aroused my interest in the process of domestication. They were F1 hybrids of wild Greylags and domestic geese and they showed surprising deviations from the normal social and sexual behaviour of the wild birds. I realised that an overpowering increase in the drives of feeding as well as of copulation and a waning of more differentiated social instincts is characteristic of very many domestic animals. I was frightened – as I still am – by the thought that analogous genetical processes of deterioration may be at work with civilized humanity. Moved by this fear, I did a very ill-advised thing soon after the Germans had invaded Austria: I wrote about the dangers of domestication and, in order to be understood, I couched my writing in the worst of nazi-terminology. I do not want to extenuate this action. I did, indeed, believe that some good might come of the new rulers. The precedent narrow-minded catholic regime in Austria induced better and more intelligent men than I was to cherish this naive hope. Practically all my friends and teachers did so, including my own father who certainly was a kindly and humane man. None of us as much as suspected that the word “selection”, when used by these rulers, meant murder. I regret those writings not so much for the undeniable discredit they reflect on my person as for their effect of hampering the future recognition of the dangers of domestication.
https://en.wikipedia.org/wiki?curid=17077
777,770
1,628,398
Forestry research has long been conducted by governmental agencies responsible for management of federal and provincial forests in Canada (Crown lands) and federal and state forests in the United States. Because timber and pulp resources are harvested from multiple use regions of public forests in North America, re-seeding or planting seedlings onto harvested sites has been a routine management practice for many decades. Research for improving silviculture practices has included tree provenance trials, by which a variety of seed sources (or provenances) are planted together at several distinct geographic test sites ("common gardens") across the current and, increasingly, potential range of a species. Because provenance trial data are available for many widespread, commercially valuable tree species, forestry professionals already have long-term experiments underway for testing tree species and population viability and performance in locations outside of native geographic ranges. Provenance trial locations poleward of native ranges or at higher (and thus cooler) elevations help forest managers determine whether, where, and when assisted migration as a climate adaptation measure should be implemented.
https://en.wikipedia.org/wiki?curid=66931587
1,627,479
1,468,470
Intellectual men of letters like the versatile Shen Kuo dabbled in subjects as diverse as mathematics, geography, geology, economics, engineering, medicine, art criticism, archaeology, military strategy, and diplomacy, among others. On a court mission to inspect a frontier region, Shen Kuo once made a raised-relief map of wood and glue-soaked sawdust to show the mountains, roads, rivers, and passes to other officials. He once computed the total number of possible situations on a game board, another time the longest possible military campaign given the limits of human carriers who would bring their own food and food for other soldiers. Shen Kuo is also noted for improving the designs of the inflow clepsydra clock for a more efficient higher-order interpolation, the armillary sphere, the gnomon, and the astronomical sighting tube; increasing its width for better observation of the pole star and other celestial bodies. Shen Kuo also experimented with camera obscura, only a few decades after the first to do so, Ibn al-Haytham (965–1039).
https://en.wikipedia.org/wiki?curid=10444102
1,467,646
1,098,247
Experiments conducted by the Franklin Institute, Boston, in the 1830s had initially cast doubt on the practice of adding water as soon as the escape of steam through the device was noted. A steam boiler was fitted with a small observation window of glass and heated beyond its normal operating temperature with the water level below the top of the firebox. When water was added it was found that the pressure rose suddenly and the observation glass shattered. The report concluded that the high temperature of the metal had vaporised the added water too quickly and that an explosion was the inevitable result. It was not until 1852 that this assumption was challenged: Thomas Redmond, one of the Institute's own inspectors, specifically ruled out this theory in his investigation into the boiler explosion on the steam ship "Redstone" on the Ohio River on 3 April that year. A 1907 investigation in Wales came to a similar conclusion: a steam locomotive belonging to the Rhymney Railway was inadvertently sent out with its safety valves wrongly assembled. The pressure in the boiler built up to the extent that the injectors failed; the crown sheet became uncovered, was weakened by the heat of the fire and violently blew apart. The investigation, led by Colonel Druitt of the Railway Inspectorate, dismissed the theory that the enginemen had succeeded in starting the injectors and that the sudden flood of cold water had caused such a generation of steam that the boiler burst. He quoted the results of experiments by the Manchester Steam Users' Association, a national boiler certification and insurance body, that proved that the weight of copper present (considered with its specific heat) was insufficient to generate enough steam to raise the boiler pressure at all. Indeed, the addition of cold water had caused the pressure to fall. From then on it was accepted that the correct action in the event of the operation of the fusible plug was to add water.
https://en.wikipedia.org/wiki?curid=4652142
1,097,687
1,169,094
Beginning with the landmark launch of Sputnik in 1957, the first man-made satellite, members of the aeronautical and military spheres realized that satellite-based positioning was technically feasible, perhaps likely. The United States Navy experimented with the technology in 1960, launching the Transit positioning satellites which was mainly used for submarine navigation, in particular for initializing their on-board ballistic missiles. However, Transit only provided two-dimensional, periodic fixes every several hours with an accuracy of about 1/10th to 1/4 mile. Additional, satellite-based, navigation systems were proposed or launched throughout the 1960s including by the USAF/Aerospace Corporation, the Johns Hopkins Applied Physics Laboratory, and the Naval Research Laboratory. But because of the secrecy and competition for budgets, of such military endeavors, collaboration was minimal. Also, their collective promise of accuracy was not credible to Pentagon officials and they publicly voiced their skepticism of the whole premise. They did not believe the usefulness would justify the cost. Parkinson was met with extreme resistance, but used small-scale prototypes sell what would go on to become GPS.
https://en.wikipedia.org/wiki?curid=2410578
1,168,476
334,351
The striking segmented pattern of the spine is established during embryogenesis when somites are rhythmically added to the posterior of the embryo. Somite formation begins around the third week when the embryo begins gastrulation and continues until all somites are formed. Their number varies between species: there are 42 to 44 somites in the human embryo and around 52 in the chick embryo. The somites are spheres, formed from the paraxial mesoderm that lies at the sides of the neural tube and they contain the precursors of spinal bone, the vertebrae ribs and some of the skull, as well as muscle, ligaments and skin. Somitogenesis and the subsequent distribution of somites is controlled by a clock and wavefront model acting in cells of the paraxial mesoderm. Soon after their formation, sclerotomes, which give rise to some of the bone of the skull, the vertebrae and ribs, migrate, leaving the remainder of the somite now termed a dermamyotome behind. This then splits to give the myotomes which will form the muscles and dermatomes which will form the skin of the back. Sclerotomes become subdivided into an anterior and a posterior compartment. This subdivision plays a key role in the definitive patterning of vertebrae that form when the posterior part of one somite fuses to the anterior part of the consecutive somite during a process termed resegmentation. Disruption of the somitogenesis process in humans results in diseases such as congenital scoliosis. So far, the human homologues of three genes associated to the mouse segmentation clock, (MESP2, DLL3 and LFNG), have been shown to be mutated in cases of congenital scoliosis, suggesting that the mechanisms involved in vertebral segmentation are conserved across vertebrates. In humans the first four somites are incorporated in the base of the occipital bone of the skull and the next 33 somites will form the vertebrae, ribs, muscles, ligaments and skin. The remaining posterior somites degenerate. During the fourth week of embryogenesis, the sclerotomes shift their position to surround the spinal cord and the notochord. This column of tissue has a segmented appearance, with alternating areas of dense and less dense areas.
https://en.wikipedia.org/wiki?curid=33607453
334,173
51,141
Dramatic declines in amphibian populations, including population crashes and mass localized extinction, have been noted since the late 1980s from locations all over the world, and amphibian declines are thus perceived to be one of the most critical threats to global biodiversity. In 2004, the International Union for Conservation of Nature (IUCN) reported stating that currently birds, mammals, and amphibians extinction rates were at minimum 48 times greater than natural extinction rates—possibly 1,024 times higher. In 2006, there were believed to be 4,035 species of amphibians that depended on water at some stage during their life cycle. Of these, 1,356 (33.6%) were considered to be threatened and this figure is likely to be an underestimate because it excludes 1,427 species for which there was insufficient data to assess their status. A number of causes are believed to be involved, including habitat destruction and modification, over-exploitation, pollution, introduced species, global warming, endocrine-disrupting pollutants, destruction of the ozone layer (ultraviolet radiation has shown to be especially damaging to the skin, eyes, and eggs of amphibians), and diseases like chytridiomycosis. However, many of the causes of amphibian declines are still poorly understood, and are a topic of ongoing discussion.
https://en.wikipedia.org/wiki?curid=621
51,121
43,118
Dustin Hoffman was cast as Liebkind in the Mel Brooks film "The Producers" (1967), but before filming began Hoffman begged Brooks to let him go to audition for "The Graduate". When Dustin Hoffman auditioned for the role of Benjamin, he was just short of his 30th birthday at the time of filming. He was asked to perform a love scene with Ross, having previously never done one during his acting classes and believed that, as he said later, "a girl like [Ross] would never go for a guy like me in a million years." Ross agreed, believing that Hoffman "look[ed] about 3 feet tall ... so unkempt. This is going to be a disaster." Producer Joseph E. Levine later admitted that he at first believed that Hoffman "was one of the messenger boys." Despite—or perhaps because of—Hoffman's awkwardness, Nichols chose him for the film. "As far as I'm concerned, Mike Nichols did a very courageous thing casting me in a part that I was not right for, meaning I was Jewish," said Hoffman. "In fact, many of the reviews were very negative. It was kind of veiled anti-Semitism... I was called 'big-nosed' in the reviews, 'a nasal voice'." Hoffman was paid $20,000 for his role in the film, but netted just $4,000 after taxes and living expenses. After spending that money, Hoffman filed for New York State unemployment benefits, receiving $55 per week while living in a two-room apartment in the West Village of Manhattan.
https://en.wikipedia.org/wiki?curid=29942
43,102
1,182,229
Arriving at Barmouth on the evening of 23 August, Charles met up with a "reading party" of Cambridge friends for a time before he left on the morning of 29 August, to go back to Shrewsbury and on to partridge shooting with his Wedgwood relatives at Maer Hall. He was grieved to have received a message that Ramsay had died. This upset Darwin's plans for a visit in the following year to Tenerife. He arrived home at The Mount, Shrewsbury, on 29 August, and found a letter from John Stevens Henslow. The Cambridge Fellow George Peacock had heard from Francis Beaufort of plans for the second survey voyage of HMS "Beagle", and had written to Henslow proposing Leonard Jenyns as "a proper person to go out as a naturalist with this expedition", or if he was unavailable seeking recommendations for an alternative to take up this "glorious opportunity". When Jenyns decided not to leave his parish, he and Henslow thought of Darwin. Henslow's letter, read by Peacock and forwarded to Darwin, expected him to eagerly catch at the likely offer of a two-year trip to Terra del Fuego & home by the East Indies, not as "a "finished" Naturalist", but as a "gentleman" "amply qualified for collecting, observing, & noting any thing worthy to be noted in Natural History". The appointment was more as a companion to Captain Robert FitzRoy, than as a mere collector. Henslow wrote "I assure you I think you are the very man they are in search of".
https://en.wikipedia.org/wiki?curid=2087722
1,181,604
701,848
William Sharpe was born on June 16, 1934 in Boston, Massachusetts. As his father was in the National Guard, the family moved several times during World War II, until they finally settled in Riverside, California. Sharpe spent the rest of his childhood and teenage years in Riverside, graduating from Riverside Polytechnic High School in 1951. He then enrolled at the University of California, Berkeley planning to pursue a degree in medicine. However, in the first year he decided to change his focus and moved to the University of California, Los Angeles to study business administration. Finding that he was not interested in accounting, Sharpe had a further change in preferences, finally majoring in economics. During his undergraduate studies, two professors had a large influence on him: Armen Alchian, a professor of economics who became his mentor, and J. Fred Weston, a professor of finance who first introduced him to Harry Markowitz's papers on portfolio theory. While at UCLA, Sharpe became a member of the Theta Xi Fraternity and Phi Beta Kappa Society. He earned a B.A. in 1955, an M.A. in 1956, and a Ph.D. in 1961, all from UCLA.
https://en.wikipedia.org/wiki?curid=402435
701,483
526,555
New and revised "phylogenetic" classification systems of the plant kingdom were produced by several botanists, including August Eichler. A massive 23 volume " was published by Adolf Engler & Karl Prantl over the period 1887 to 1915. Taxonomy based on gross morphology was now being supplemented by using characters revealed by pollen morphology, embryology, anatomy, cytology, serology, macromolecules and more. The introduction of computers facilitated the rapid analysis of large data sets used for numerical taxonomy (also called taximetrics or phenetics). The emphasis on truly natural phylogenies spawned the disciplines of cladistics and phylogenetic systematics. The grand taxonomic synthesis "An Integrated System of Classification of Flowering Plants" (1981) of American Arthur Cronquist (1919–1992) was superseded when, in 1998, the Angiosperm Phylogeny Group published a phylogeny of flowering plants based on the analysis of DNA sequences using the techniques of the new molecular systematics which was resolving questions concerning the earliest evolutionary branches of the angiosperms (flowering plants). The exact relationship of fungi to plants had for some time been uncertain. Several lines of evidence pointed to fungi being different from plants, animals and bacteria – indeed, more closely related to animals than plants. In the 1980s-90s molecular analysis revealed an evolutionary divergence of fungi from other organisms about 1 billion years ago – sufficient reason to erect a unique kingdom separate from plants.
https://en.wikipedia.org/wiki?curid=25007304
526,282
414,957
Saxicolous crustose lichens play an important role in the weathering of rocks. Repeated contraction and expansion of thalli occurs in response to alternate periods of wetting and drying, resulting in the breakdown of rock fragments and removal of mineral grains from the rock surfaces. Crustose lichens also chemically weather rocks through hydrolysis. In a study conducted by Kitagawa and Watanabe (2004), the crustose genus "Porpidia" altered minerals, specifically biotite in granite. Furthermore, vermiculite-like minerals were formed as a result of biotite alteration through hydrolysis. Crustose lichens living in karst areas have substantial influence on carbon dioxide flux at the boundary between the lithosphere and atmosphere because they increase the rates of corrosion of carbonate rocks in these areas. Some species of crustose lichens exhibit antibiotic properties. "Lepraria chlorina" contains substantial amounts of vulpinic acid, which is a chemical that has anti-inflammatory properties. Crustose lichens may also be used for dating rock surfaces, through a technique called lichenometry. As soon as a rock is exposed to the Earth’s atmosphere, spores of various organisms are driven into the crevices on the surface. The majority of these spores die under the extreme conditions of a rock surface, an area where water evaporates rapidly and daily fluxes in temperatures are quite large. The spores of some crustose lichens, however, can develop on these surfaces. Eventually the crustose spores form small and round thalli and increase in diameter yearly. When lichens are used for dating a rock surface, only the diameters of the largest thalli of one species are measured, as there is an assumption that only they began development when the surface was initially exposed. The age of exposure of a rock surface is then extrapolated from records.
https://en.wikipedia.org/wiki?curid=43816379
414,754
1,128,648
Throughout the 1980s, Northeastern University made about 38 program and curriculum changes to improve the university. Between 1979 and 1981, Northeastern organized a blue-ribbon panel of educators and experts, including industry leaders from Bell Labs, University of California, Berkeley, Massachusetts Institute of Technology (MIT) and the Digital Equipment Corporation, to develop a plan to advance education and research in the emerging field of computer science. In 1982, Northeastern formally established the College of Computer Science (CCS), the first U.S. college devoted to computer science and the first new college at Northeastern in 17 years. Paul Kalaghan, director of Academic Computer Services, was named its first dean. The college was initially housed in Knowles-Volpe Hall, now known as the Asa S. Knowles Center, with 11 faculty members and 239 first-year students. Graduate degree programs were added in 1984. A year later, the college moved into the former Botolph Building, one of the oldest structures on campus, which reopened as the David and Margaret Fitzgerald Cullinane Hall. At the end of 1987, the CCS proposed the Law of Demeter, which was widely used in software development area. In 2004, the college moved into the newly constructed West Village H building, which consists of a six-story building and a 16-story tower containing the Khoury College of Computer Science and on-campus housing for 485 students.
https://en.wikipedia.org/wiki?curid=27792666
1,128,070
309,675
U.S. athletes have appeared in every Summer Olympics of the modern era. The United States, represented by the United States Olympic & Paralympic Committee (USOPC), competed at the 2020 Summer Olympics in Tokyo. Originally scheduled to take place in the summer of 2020, the Games were postponed to July 23 to August 8, 2021, due to the COVID-19 pandemic. The opening ceremony flag-bearers for the United States were baseball player Eddy Alvarez and basketball player Sue Bird. Javelin thrower Kara Winger was the flag-bearer for the closing ceremony. When USA Gymnastics announced that 2016 Olympic all-around champion Biles would not participate in the gymnastics all-around final, the spotlight fell on her American team-mates. The U.S. had won the event in each of the last five Olympic Games: a formidable winning streak was on the line. Sunisa Lee embraced the moment and stood tall to deliver for her country. She totaled 57.433 to hold off Rebeca Andrade of Brazil (57.298) to clinch the title. Lee also made history of her own. With victory in the all-around she became the first Hmong American gymnast to win an Olympic gold medal. With a silver in the women's team final and bronze in the individual uneven bars Lee left Tokyo with an impressive three Olympic medals. Lydia Jacoby Alaska's swimming sweetheart made history when she was the first Alaskan swimmer selected to make the U.S. Olympic swim team. She stunned the world to secure victory in the women's 100m breaststroke. Recent major champion Nelly Korda followed the winning ways of compatriot Xander Schauffele to take home gold in the women's golf competition. The 2.01m-tall thrower Ryan Crouser retained his Olympic title in the men's shot put and did so in some style, setting an Olympic record three times.
https://en.wikipedia.org/wiki?curid=2112059
309,508
803,931
If choking on skill-based or co-ordination oriented tasks requires the pressure of the situation to cause the performer's increased conscious attention to his or her process of performance, then the reverse can also be true. A relatively unexplored area of scientific research is the concept of "rising to the occasion." One common misconception is that a person must be an expert in order to have consistent success under pressure. On the contrary, implicit knowledge has been hypothesized to only partially mediate the relationship between expertise and performance. It works closely with a perceived control of the task, and can often trump expertise if the performer embodies procedural comfort within the domain. Traditionally, "rising to the occasion" or being "clutch" has been used in reference to sporting feats of particular excellence given the magnitude of the event, however there is increasing awareness to the phenomenon in our everyday life. How one performs under circumstances that do not necessarily present immediate or grave consequence, but do require the performer to actively access a conscious mechanism to perform in unfamiliar or uncomfortable settings, is a concept that may prove educationally beneficial across a variety of disciplines and activities.
https://en.wikipedia.org/wiki?curid=21312313
803,502
612,846
Minkowski in his earlier works in 1907 and 1908 followed Poincaré in representing space and time together in complex form (x,y,z,ict) emphasizing the formal similarity with Euclidean space. He noted that spacetime is in a certain sense a four-dimensional non-Euclidean manifold. Sommerfeld (1910) used Minkowski's complex representation to combine non-collinear velocities by spherical geometry and so derive Einstein's addition formula. Subsequent writers, principally Varićak, dispensed with the imaginary time coordinate, and wrote in explicitly non-Euclidean (i.e. Lobachevskian) form reformulating relativity using the concept of rapidity previously introduced by Alfred Robb (1911); Edwin Bidwell Wilson and Gilbert N. Lewis (1912) introduced a vector notation for spacetime; Émile Borel (1913) showed how parallel transport in non-Euclidean space provides the kinematic basis of Thomas precession twelve years before its experimental discovery by Thomas; Felix Klein (1910) and Ludwik Silberstein (1914) employed such methods as well. One historian argues that the non-Euclidean style had little to show "in the way of creative power of discovery", but it offered notational advantages in some cases, particularly in the law of velocity addition. (So in the years before World War I, the acceptance of the non-Euclidean style was approximately equal to that of the initial spacetime formalism, and it continued to be employed in relativity textbooks of the 20th century.
https://en.wikipedia.org/wiki?curid=1790788
612,535
745,235
Two ideas about the homology of arms, hands and digits have existed in the past 130 years. First that digits are unique to tetrapods and second that antecedents were present in the fins of early sarcopterygian fish. Until recently it was believed that "genetic and fossil data support the hypothesis that digits are evolutionary novelties". However new research that created a three-dimensional reconstruction of Panderichthys, a coastal fish from the Devonian period 385 million years ago, shows that these animals already had many of the homologous bones present in the forelimbs of limbed vertebrates. For example, they had radial bones similar to rudimentary fingers but positioned in the arm-like base of their fins. Thus there was in the evolution of tetrapods a shift such that the outermost part of the fins were lost and eventually replaced by early digits. This change is consistent with additional evidence from the study of actinopterygians, sharks and lungfish that the digits of tetrapods arose from pre-existing distal radials present in more primitive fish. Controversy still exists since Tiktaalik, a vertebrate often considered the missing link between fishes and land-living animals, had stubby leg-like limbs that lacked the finger-like radial bones found in the Panderichthys. The researchers of the paper commented that it "is difficult to say whether this character distribution implies that Tiktaalik is autapomorphic, that Panderichthys and tetrapods are convergent, or that Panderichthys is closer to tetrapods than Tiktaalik. At any rate, it demonstrates that the fish–tetrapod transition was accompanied by significant character incongruence in functionally important structures.".
https://en.wikipedia.org/wiki?curid=37824359
744,841
822,941
CCDE runs in parallel with the more established CCIE program, in some areas providing a higher skill-set than CCIE. Specifically, CCDE identifies network professionals who have expert network design skills. Network design translates business requirements into end-to-end network designs and a solutions approach to network expansion and integration. CCDE focuses on network architecture and does not cover implementation and operations. CCDE supplies a vendor-neutral curriculum, testing business requirements analysis, design, planning, and validation practices. The course came about because employers needed a way to identify experienced network designers and architects who could address all aspects of existing and new networking technologies and trends. While engineers (including many CCIEs) had fulfilled this role, certification had not advanced beyond the CCDP certification. CCDE numbering adopts a different format than CCIE and appears split into a year and number within that year. It uses the same CCIE tools to verify qualified status. CCDE certified individuals can use CCIE qualification exams to re-certify and vice versa. CCDE provides advanced network infrastructure design principles and fundamentals for large networks. A CCDE can demonstrate an ability to develop solutions which address planning, design, integration, optimization, operations, security, and ongoing support focused at the infrastructure level.
https://en.wikipedia.org/wiki?curid=3696371
822,500
1,184,562
On August 26, the expedition went to Tenerife with the aim of stocking up on wine and fresh supplies. While being in England, three sailors from the sloop "Mirny" got a sexually transmitted infection. However, Dr Galkin's prognosis was favorable; there were no sick people on "Vostok". In the Atlantic, a working rhythm was established on the sloops: the crews were divided into three shifts. This system allowed sailors to wake up an already rested part of the team in the event of an emergency. In rainy and stormy weather, the watch commanders were instructed to ensure that the "servants" changed clothes, and the wet clothes were stored outside the living deck and dried in the wind. On Wednesdays and Fridays, there was a bath-washing day (in these days one boiler on the caboose was used for these purposes, which allowed the use of hot water). The bunks were also washed on the 1st and 15th of each month. General deck cleaning was usually done on the move twice a week, and daily during the long stayings. The living deck was regularly ventilated and heated "to thin the air", and if the weather allowed, the crew took food on quarterdecks and forecastles, "so that decks do not leave damp fumes and impurities". On September 10, a vent pipe was put through the captain's cabin. This was to keep the constable and brotkamera dry. The constable was a room on the lower deck from the stern to the main mast – or the aft cabin on the middle deck – which contained artillery supplies, which the brotkamera was a room for keeping dry provisions, primarily flour and crackers. The vent pipe was necessary because the brotkamera leaked and the officers’ flour got wet and rotted.
https://en.wikipedia.org/wiki?curid=40880361
1,183,935
2,037,912
The 394th received a second Distinguished Unit Citation for action on 19 March 1945. The 367th Group's target was the headquarters of Field Marshal Kesselring, the German Commander-ln-Chief, West, at Ziegenburg near Bad Nauheim, Germany. The 394th would lead the attack at low level to achieve surprise, carrying a 1,000-pound bomb under each wing. The P-47s of the 392d Fighter Squadron would be similarly armed, but would dive bomb from a higher altitude. The bombs were equipped with time-delay fuses intended to crack the concrete roofs of the bunker. The 393rd Fighter Squadron carried napalm intended to seep into the bunkers and burn what remained. The attack was scheduled for a time that intelligence reports indicated would find senior staff and commanders at lunch, the only time they would not be in the reinforced tunnels underneath the castle that housed the headquarters. The target was located in mountainous terrain well defended by antiaircraft artillery. Moreover, to avoid alerting the Germans to the pending attack, photographic reconnaissance aircraft had avoided the area, so detailed target photography was not available. The day of the attack the castle was concealed by ground haze which caused the 394th squadron to stray off course at the last minute, preventing them from executing the attack as planned and reducing the element of surprise. Instead, the 392nd fighter squadron lead the attack, scoring direct hits on the castle. Although senior German officers reached the underground bunkers and survived the attack, the group reduced the military complex to ruins, disrupting communications and the flow of intelligence at a critical time.
https://en.wikipedia.org/wiki?curid=29476024
2,036,737
546,173
Transcriptomics methods are highly parallel and require significant computation to produce meaningful data for both microarray and RNA-Seq experiments. Microarray data is recorded as high-resolution images, requiring feature detection and spectral analysis. Microarray raw image files are each about 750 MB in size, while the processed intensities are around 60 MB in size. Multiple short probes matching a single transcript can reveal details about the intron-exon structure, requiring statistical models to determine the authenticity of the resulting signal. RNA-Seq studies produce billions of short DNA sequences, which must be aligned to reference genomes composed of millions to billions of base pairs. "De novo" assembly of reads within a dataset requires the construction of highly complex sequence graphs. RNA-Seq operations are highly repetitious and benefit from parallelised computation but modern algorithms mean consumer computing hardware is sufficient for simple transcriptomics experiments that do not require "de novo" assembly of reads. A human transcriptome could be accurately captured using RNA-Seq with 30 million 100 bp sequences per sample. This example would require approximately 1.8 gigabytes of disk space per sample when stored in a compressed fastq format. Processed count data for each gene would be much smaller, equivalent to processed microarray intensities. Sequence data may be stored in public repositories, such as the Sequence Read Archive (SRA). RNA-Seq datasets can be uploaded via the Gene Expression Omnibus.
https://en.wikipedia.org/wiki?curid=54112223
545,887
1,587,283
The All India Council for Technical Education (AICTE) attempted to de-recognize the college in the 2010–2011 academic year, after which the college management went to court seeking a stay on the order for a year. The college got the stay, and later also managed to get it extended for the academic year 2011–2012. However, when it tried to do the same for the 2012–2013 academic year, the Bombay High Court refused and upheld the AICTE's order in a ruling on 22 August 2012. The AICTE had not granted the Extension of Approval to continue the undergraduate courses in the college, (thus halting its first-year admissions in the DTE-managed CAP rounds of 2012) and had directed the college to shut down immediately, transferring the current students to other engineering colleges of the University of Mumbai. An "expert committee" of the AICTE visited the college for inspection on 6 August 2012, and after inspection it gave a "zero deficiency" report regarding the college infrastructure, facilities, etc. But even then, AICTE did not change its decision of derecognising the college. The Yuva Sena (youth wing of the Shiv Sena political party) protested the AICTE decision at the Mumbai regional office of the AICTE. A contentious issue in the matter of the college not being allowed to function was the college not possessing the required Occupancy Certificate from the Thane Municipal Corporation. But on 27 August 2012, the college obtained the Occupancy Certificate, and then challenged the High Court ruling by appealing in the Supreme Court of India. The hearing was expected on 29 August 2012, but it was postponed to 4 September 2012 due to late availability of the High Court order copy. Classes, examinations and other works continued at the college till December 2012, when the Supreme Court issued its verdict in favour of AICTE. Thus, PCoE had to be closed down and all current students were transferred (by the Directorate of Technical Education of the state Government of Maharashtra) to other engineering colleges of the University of Mumbai. But the Supreme Court also imposed a fine of Rs 50,000 on AICTE for the delay of two years (2008–2009 and 2009–2010) in its initiative to investigate the case of the college (under the previous trustee Mr. Tekchand Shah) shifting campuses without following proper procedures.
https://en.wikipedia.org/wiki?curid=36213463
1,586,389
1,498,219
Communal traits of social organization can be also found looking at the communal buildings. These buildings were built up by and for the "masoveros", the inhabitants of Mas Blanco. The storage of rainwater was possible thanks to the cistern ("aljibe"), built with a seven-meter vault, and allowed the watering of the livestock. The building for the pressing of the vine and storage of the wine was managed in a way that according to the quantity of vine that each family harvested, they took the equivalent amount in wine. Another important example is the common oven. Every 15 days, each family was in charge of turning on it in order to reach the right temperature for cooking food such as bread. Furthermore, Mas Blanco's inhabitants, due to the fact of the hard winters and the insecurity of the paths during the postwar period that followed the Spanish Civil War, decided to carry out the project of building a school for their children. After getting the permission of the Civil Government, the inhabitants were the ones that managed to build up the building which was finished in the 1950. Together with the school, a house for the teacher was constructed as well. Another example of communal practices in Mas Blanco and San Agustin's area can be found in the so-called “luck of firewood”, which has lasted until today. Every year the city council raffles municipal and communal forest plots so that neighbourhoods are associated to a plot in which they can collect firewood to heat the houses.
https://en.wikipedia.org/wiki?curid=63796902
1,497,375
241,753
The DOI system offers persistent, semantically interoperable resolution to related current data and is best suited to material that will be used in services outside the direct control of the issuing assigner (e.g., public citation or managing content of value). It uses a managed registry (providing social and technical infrastructure). It does not assume any specific business model for the provision of identifiers or services and enables other existing services to link to it in defined ways. Several approaches for making identifiers persistent have been proposed. The comparison of persistent identifier approaches is difficult because they are not all doing the same thing. Imprecisely referring to a set of schemes as "identifiers" doesn't mean that they can be compared easily. Other "identifier systems" may be enabling technologies with low barriers to entry, providing an easy to use labeling mechanism that allows anyone to set up a new instance (examples include Persistent Uniform Resource Locator (PURL), URLs, Globally Unique Identifiers (GUIDs), etc.), but may lack some of the functionality of a registry-controlled scheme and will usually lack accompanying metadata in a controlled scheme. The DOI system does not have this approach and should not be compared directly to such identifier schemes. Various applications using such enabling technologies with added features have been devised that meet some of the features offered by the DOI system for specific sectors (e.g., ARK).
https://en.wikipedia.org/wiki?curid=422994
241,627
1,694,742
Colgate finally returned to the ice in 1958 and continued with new head coach Olav Kollevoll for two seasons before their first indoor ice rink was finished. The building was dedicated to the former coach as the J. Howard Starr Rink at the first game played on its surface in December 1959. With the stability of the program ensured the team was able to build itself into a respectable unit, producing increasing win totals into the early 1960s and founding its second conference, ECAC Hockey along with 27 other schools. Colgate finished their first year of conference play with an 18–6 mark, setting a new school record for wins and finishing tied for 6th but it wasn't enough to earn them a selection as one of the top 8 teams in the conference so they missed the playoffs. The following year saw the team slip to 7th in the ECAC but this time they received an entry into the postseason, losing to eventual champion Harvard in the quarterfinals. The next year brought the team record up to 19 wins and a second playoff berth where they once again lost to the eventual ECAC champion in their first game, this time to Providence. After a down year in 1965 Kollevoll was replaced by Ron Ryan who held the reins for seven seasons but could only lead the team to middling results most years. After two poor showings in the early '70s the team passed through three coaches over five years, eventually landing with former St. Lawrence player Terry Slater.
https://en.wikipedia.org/wiki?curid=28794663
1,693,791
1,227,257
On the other side of the platform was the transmission "wedge", 250 feet in length with a total height of 240 feet. The wedge was constructed using steel I-beams. The entire structure was covered with a wire mesh similar to livestock fencing in order to create an enormous Faraday cage. A multistory building was constructed inside the wedge which served as offices, laboratories and testing facilities. The second floor of the building housed a large electromagnetically shielded room, supplied by Electromagnetic Filter Company of Palo Alto, California, which contained the data acquisition electronics, the Marx generator charging and firing control and field strength monitoring instrumentation. The data acquisition system consisted of a large number of state-of-the-art Tektronix 7912AD digitizers along with a large array of Digital Equipment Corporation PDP-11 computers. The pulse monitoring instrumentation consisted of a number of B dot and H field sensors mounted on the exterior of the wedge connected to oscilloscopes fitted with Polaroid cameras to capture the transient pulse data. The open-air third floor held large inflatable gas bags which could store the sulfur hexafluoride (SF) gas from the Marx generator enclosures when they needed to be opened for maintenance.
https://en.wikipedia.org/wiki?curid=32682509
1,226,596
1,109,826
The best characterized form of dyskeratosis congenita is a result of one or more mutations in the long arm of the X chromosome in the gene DKC1. This results in the X-linked recessive form of the disease wherein the major protein affected is dyskerin. Of the five mutations described by Heiss and colleagues in "Nature Genetics", four were single nucleotide polymorphisms all resulting in the change of highly conserved amino acids. One case was an in-frame deletion resulting in the loss of a leucine residue, also conserved in mammals. In three of the cases, the specific amino acids affected (phenylalanine, proline, glycine) are found in the same locus in humans as they are in yeast ("S. Cerevisiae") and the brown rat ("R. Norvegicus"). This establishes the sequence conservation and importance of dyskerin within the eukaryotes. The relevant nature of dyskerin throughout most species is to catalyze the post-transcriptional pseudouridylation of specific uridines found in non-coding RNAs, such as ribosomal RNA (rRNA). Cbf5, the yeast analog of human dyskerin, is indeed known to be associated with the processing and maturation of rRNA. In humans, this role can be attributed to dyskerin. Thus, the X-linked form of this disease may result in specific issues related to dysfunctional RNA and perhaps a graver phenotype. Within the vertebrates, as opposed to single celled eukaryotes, dyskerin is a key component of the telomerase RNA component (TERC) in the form of the H/ACA motif. This X-linked variety, like the Nop10 and Nhp2 mutations, demonstrates shortened telomeres as a result of lower TERC concentrations.
https://en.wikipedia.org/wiki?curid=3076958
1,109,261
774,190
Gas flow proportional counters are used mainly for detection of longer wavelengths. Gas flows through it continuously. Where there are multiple detectors, the gas is passed through them in series, then led to waste. The gas is usually 90% argon, 10% methane ("P10"), although the argon may be replaced with neon or helium where very long wavelengths (over 5 nm) are to be detected. The argon is ionised by incoming X-ray photons, and the electric field multiplies this charge into a measurable pulse. The methane suppresses the formation of fluorescent photons caused by recombination of the argon ions with stray electrons. The anode wire is typically tungsten or nichrome of 20–60 μm diameter. Since the pulse strength obtained is essentially proportional to the ratio of the detector chamber diameter to the wire diameter, a fine wire is needed, but it must also be strong enough to be maintained under tension so that it remains precisely straight and concentric with the detector. The window needs to be conductive, thin enough to transmit the X-rays effectively, but thick and strong enough to minimize diffusion of the detector gas into the high vacuum of the monochromator chamber. Materials often used are beryllium metal, aluminised PET film and aluminised polypropylene. Ultra-thin windows (down to 1 μm) for use with low-penetration long wavelengths are very expensive. The pulses are sorted electronically by "pulse height selection" in order to isolate those pulses deriving from the secondary X-ray photons being counted.
https://en.wikipedia.org/wiki?curid=72048
773,774
252,798
The performance of the Me 163 far exceeded that of contemporary piston engine fighters. At a speed of over the aircraft would take off, in a so-called "scharfer Start" ("sharp start", with "Start" being the German word for "take-off") from the ground, from its two-wheeled dolly. The aircraft would be kept at level flight at low altitude until the best climbing speed of around was reached, at which point it would jettison the dolly, retract its extendable skid using a knob-topped release lever just forward of the throttle (as both levers were located atop the cockpit's portside 120-litre T-Stoff oxidizer tank) that engaged the aforementioned pneumatic cylinder, and then pull up into a 70° angle of climb, to a bomber's altitude. It could go higher if required, reaching in an unheard-of three minutes. Once there, it would level off and quickly accelerate to around or faster, which no Allied fighter could match. The usable Mach number was similar to that of the Me 262, but because of the high thrust-to-drag ratio, it was much easier for the pilot to lose track of the onset of severe compressibility and risk loss of control. A Mach warning system was installed as a result. The aircraft was remarkably agile and docile to fly at high speed. According to Rudolf Opitz, chief test pilot of the Me 163, it could "fly circles around any other fighter of its time".
https://en.wikipedia.org/wiki?curid=20486
252,665
897,095
One of the biggest problems in modern medicine is the lack of donated organs for patients who have organ failure and require an organ transplant. This is particularly impressive for those who have had spinal cord injuries or renal or heart problems. Even though there are more of these patients every year, the availability of donated organs is quite constrained. To prevent transplant rejection, immunological incompatibility between donors and recipients, storage space restrictions, and even dthe onor's family approval of organ donation can all have an impact on this restriction. Hence, it appears important that alternate solutions be developed. Regenerative medicine is a cutting-edge treatment strategy that combines nuclear transfer, tissue engineering, and stem cell biology to repair damaged tissue. The word was first used by William Haseltine in 1999. He discovered that embryonic SCs can differentiate into every form of human body cell. William's explanation may appear straightforward at first, but if we dig a little further, we can see how regenerative medicine has great promise for the near future and might drastically alter how we treat patients whose organs have been severely damaged or failed. Different treatment procedures have been created today and regenerative medicine has given itself a specific position, while most of them are still in the early stages.
https://en.wikipedia.org/wiki?curid=26982208
896,623
2,134,434
Both NIOSH and the US Army Aeromedical Research Laboratories funded research to investigate the classical conditioning that has been integral to the warned AHAAH model. In the warned mode, the middle ear muscles are assumed to be already contracted. In the unwarned mode, the middle ear muscles are contracted after a loud sound exceeds a threshold of about 134 dB peak SPL. Several studies conducted between 2014 and 2020 have examined the prevalence and reliability of the MEMC. According to a nationally representative survey of more than 15,000 persons, the prevalence of the acoustic reflex measured in persons aged 18 to 30 was less than 90%. A follow-on study that carefully assessed 285 persons with normal hearing concluded that "acoustic reflexes are not pervasive and should not be included in damage risk criteria and health assessments for impulsive noise." The anticipatory contraction integral to the warned response is not reliable in persons with normal hearing. The completion of the USAARL live fire exposure study demonstrated that the early activation of the MEMC was not present in 18 of 19 subjects during tests with an M4-rifle using live ammunition. Experienced shooters according to the hypothesis of the AHAAH developers would exhibit an early contraction that precedes the trigger pull. The warned hypothesis was demonstrated to be insufficiently prevalent to merit including the MEMC in subsequent damage risk criteria.
https://en.wikipedia.org/wiki?curid=57869905
2,133,209
1,116,218
Given its rarity, there have been no systematic and controlled studies on the treatment of SMZL. Current recommendations for this include the following. Watchful waiting, which is the withholding of specific treatments while performing follow-up examinations every 3 to 6 months to detect disease progression. This course is recommended for the ~33% of SMZL patients who present with asymptomatic, non-progressive, or slowly progressive disease. These patients may not require therapeutic interventions for long periods. Historically, the initial therapy for patients with rapidly progressing disease was splenectomy. Some 90% of these patients show reductions in their symptoms and improvements in their low red blood cell, platelet, and white blood cell counts; they had median progression-free, 5 year overall, and 10 year overall survival rates of 8.2 years, 84%, and 67%, respectively. However, these patients show no alteration in the neoplastic B-cells levels in their blood, were subject to serious complications from their splenectomy (e.g. thrombosis, infections), and did not show alter overall survival rates better than those obtained with other treatment strategies. Accordingly, splenectomy for SMZL has been limited to cases of significantly symptomatic enlarged spleens in patients with mild-to-moderate bone marrow involvement and no bulky lymph node enlargements.
https://en.wikipedia.org/wiki?curid=21339698
1,115,646
773,764
In the 1950s Botvinnik became interested in computers, at first mainly for playing computer chess but he later also co-authored reports on the possible use of artificial intelligence in managing the Soviet economy. Botvinnik's research on chess-playing programs concentrated on "selective searches", which used general chess principles to decide which moves were worth considering. This was the only feasible approach for the primitive computers available in the Soviet Union in the early 1960s, which were only capable of searching three or four half-moves deep (i.e. A's move, B's move, A's move, B's move) if they tried to examine every variation. Botvinnik eventually developed an algorithm that was reasonably good at finding the right move in difficult positions, but it often missed the right move in simple positions, e.g. where it was possible to checkmate in two moves. This "selective" approach turned out to be a dead end, as computers were powerful enough by the mid-1970s to perform a brute-force search (checking all possible moves) several moves deep and today's vastly more powerful computers do this well enough to beat human world champions. However, his PIONEER program contained a generalized method of decision-making that, with a few adjustments, enabled it to plan maintenance of power stations all over the USSR. On September 7, 1991 Botvinnik was awarded an honorary degree in mathematics of the University of Ferrara (Italy) for his work on computer chess.
https://en.wikipedia.org/wiki?curid=242416
773,348
2,013,940
Avery's parents devotion to their daughters education led to both Avery and her older sister to attend Moorestown Friends School, a private school in Moorestown, New Jersey. At the time, Avery was not old enough to attend school, so her mother worked to have the rules changed. Avery was able to begin her education earlier than others, which put her ahead of children in her age group. She continued to be successful in school and even skipped the seventh grade. Avery and her sister were the first in their family to attend college. She went on to attend Wheaton College while her sister finished up at New Jersey College for Women. Graduating summa cum laude from Wheaton College in 1948 with a degree in chemistry, Mary Ellen Avery continued to earn a medical degree from the Johns Hopkins University School of Medicine, where she was one of four women in a class of 90, in 1952. Emily Bacon had attended Johns Hopkins and this was a huge motivation for Avery to get in. During a time of discrimination, Avery knew she had to instill confidence in herself. She once stated, “I know as much as you know. I’ve been to the best school I could get into.” Avery obtained several mentors during her time at Johns Hopkins, which included Dr. Helen Taussig and Dr. Harriet Guild. Being only one of four women, Avery received a lot of attention from her mentors. Soon after graduating, Dr. Avery was diagnosed with tuberculosis, and it was during her recuperation that she became fascinated with how the lungs work. Rest and medication would cure her, but she went about the regimen her own way. Once she realized she was exhibiting no symptoms, she decided to go to Europe with a friend. "I packed one suitcase of medication and another suitcase of clothes, and spent three months in Europe on a regimen that I programmed for myself," Avery said. "It consisted of 12 hours in bed every night, and in the daytime mostly walking around and looking at exhibits and enjoying myself, but not anything strenuous."
https://en.wikipedia.org/wiki?curid=8596148
2,012,781
1,646,105
Things did improve for Churchill-Redman and the sales rose dramatically from £200,000 in 1946 to £1M by 1955. This was in part because of innovative product development at the Halifax site which ultimately produced the CR P5 and P6 profiling lathes: the conclusion of this development is described by Jeremy as being a range of "fully automatic, multi-tool and profiling lathes. A lathe with an automatic feed and delivery heralded an automatic machine tool production line." The expansion of the motor vehicle industry once again was a significant factor, driving demand for machine tools much as the bicycling boom of the 1890s had done. In 1957 the Scotswood operation moved across the River Tyne to Blaydon, where a factory was built especially for the manufacturing purpose intended. Among other products from that site was the Vertimax lathe, which used a vertical spindle and was of interest to motor vehicle manufacturers. This particular design originated from James Anderson, a garage owner in Glasgow, during the war and whose business was brought into the Churchill group of companies. Churchill Gear Machines Ltd was part of the group, having been established in Blaydon since 1956: the cause of its origin and the nature of its products is uncertain.
https://en.wikipedia.org/wiki?curid=30046818
1,645,176
195,978
IgE, the IgE synthesis pathway, and the IgE-mediated allergic/inflammatory pathway are all important targets in intervening with the pathological processes of allergy, asthma, and other IgE-mediated diseases. The B lymphocyte differentiation and maturation pathway that eventually generate IgE-secreting plasma cells go through the intermediate steps of IgE-expressing B lymphoblasts and involves the interaction with IgE-expressing memory B cells. Tanox, a biotech company based in Houston, Texas, proposed in 1987 that by targeting membrane-bound IgE (mIgE) on B lymphoblast and memory B cells, those cells can be lysed or down-regulated, thus achieving the inhibition of the production of antigen-specific IgE and hence a shift of immune balance toward non-IgE mechanisms. Two approaches targeting the IgE pathway were evolved and both are in active development. In the first approach, the anti-IgE antibody drug omalizumab (trade name Xolair) recognises IgE not bound to its receptors and is used to neutralise or mop-up existing IgE and prevent it from binding to the receptors on mast cells and basophils. Xolair has been approved in many countries for treating severe, persistent allergic asthma. It has also been approved in March 2014 in the European Union and the U. S. for treating chronic spontaneous urticaria, which cannot be adequately treated with H1-antihistamines. In the second approach, antibodies specific for a domain of 52 amino acid residues, referred to as CεmX or M1’ (M1 prime), present only on human mIgE on B cells and not on free, soluble IgE, have been prepared and are under clinical development for the treatment of allergy and asthma. An anti-M1’ humanized antibody, quilizumab, is in phase IIb clinical trial.
https://en.wikipedia.org/wiki?curid=490670
195,878
1,805,592
Initial planning for the Apollo Program included provisions for in-flight measurements of salient parameters of concern including physiological responses to exercise. However, the fire in the Apollo 204 spacecraft (also known as Apollo 1), fatal to astronauts Grissom, White, and Chaffee, resulted in NASA management initiating changes in the program that eliminated such prospects. This, investigators were left with only the possibility to conduct pre-flight and post-flight exercise response studies and to assume that these findings reflected alterations of cardiopulmonary and skeletal muscle function secondary to microgravity exposure. It was realized early on that within the context and constraints imposed by the realities of the Apollo missions, the inability to control certain experiment variables would present challenges to many biomedical investigations. Firstly, re-adaption to Earth gravity procedures introduced additional challenges to a well-controlled experiment design since Apollo crew members spent variable amounts of time in an uncomfortably warm spacecraft bobbing in the ocean and additionally, orbital mechanics constraints on re-entry times imposed crew recovery times that prevented the possibility of conducting pre- and post-flight testing within a similar circadian schedule. The effect of these uncontrollable conditions and that of other physical and psychological stresses could not be separated from responses attributable to microgravity exposure alone. Thus, data relating to the physiological responses to exercise stress in Apollo astronauts must be interpreted within this overall context.
https://en.wikipedia.org/wiki?curid=39377992
1,804,577
10,166
MIT has kept pace with and helped to advance the digital age. In addition to developing the predecessors to modern computing and networking technologies, students, staff, and faculty members at Project MAC, the Artificial Intelligence Laboratory, and the Tech Model Railroad Club wrote some of the earliest interactive computer video games like "Spacewar!" and created much of modern hacker slang and culture. Several major computer-related organizations have originated at MIT since the 1980s: Richard Stallman's GNU Project and the subsequent Free Software Foundation were founded in the mid-1980s at the AI Lab; the MIT Media Lab was founded in 1985 by Nicholas Negroponte and Jerome Wiesner to promote research into novel uses of computer technology; the World Wide Web Consortium standards organization was founded at the Laboratory for Computer Science in 1994 by Tim Berners-Lee; the OpenCourseWare project has made course materials for over 2,000 MIT classes available online free of charge since 2002; and the One Laptop per Child initiative to expand computer education and connectivity to children worldwide was launched in 2005.
https://en.wikipedia.org/wiki?curid=18879
10,162
1,931,703
The DARPA Quantum Network was built in stages. In the project's first year (year 1), BBN designed and built a full QKD system (Alice and Bob), with an attenuated laser source (~ 0.1 mean photon number) running through telecom fiber, phase-modulated via an actively stabilized Mach-Zender interferometer. BBN also implemented a full suite of industrial-strength QKD protocols based on BB84. In year 2, BBN created two 'Mark 2' versions of this system (4 nodes) with commercial-quality InGaAs detectors created by IBM Research. These 4 nodes ran continuously in BBN's laboratory from October 2003, then two were deployed at Harvard and Boston University in June 2004, when the network began running continuously across the metro Boston area, 24x7. In year 3, the network expanded to 8 nodes with the addition of an entanglement-based system (derived from work at Boston University) designed for telecom fibers, and a high-speed atmospheric (freespace) link designed and built by the National Institute of Standards and Technology. In year 4, BBN added a second freespace link to the overall network, using nodes created by Qinetiq, and investigated improved QKD protocols and detectors. Finally, in year 5, BBN added the world's first superconducting nanowire single-photon detector to the operational network. It was created by a collaboration between researchers at BBN, the University of Rochester, and the National Institute of Standards and Technology; that first 100 Mhz system ran 20x faster than any existing single-photon detector at telecom wavelengths. In that final year, BBN also collaborated with researchers at the Massachusetts Institute of Technology to implement, and experiment with, a proof-of-concept version of the world's first quantum eavesdropper (Eve).
https://en.wikipedia.org/wiki?curid=61603586
1,930,595
7,196
The first ISS component was launched in 1998, and the first long-term residents arrived on 2 November 2000 after being launched from the Baikonur Cosmodrome on 31 October 2000. The station has since been continuously occupied for , the longest continuous human presence in low Earth orbit, having surpassed the previous record of held by the "Mir" space station. The latest major pressurised module, "Nauka", was fitted in 2021, a little over ten years after the previous major addition, "Leonardo" in 2011. Development and assembly of the station continues, with an experimental inflatable space habitat added in 2016, and several major new Russian elements scheduled for launch starting in 2021. In January 2022, the station's operation authorization was extended to 2030, with funding secured within the United States through that year. There have been calls to privatize ISS operations after that point to pursue future Moon and Mars missions, with former NASA Administrator Jim Bridenstine stating: "given our current budget constraints, if we want to go to the moon and we want to go to Mars, we need to commercialize low Earth orbit and go on to the next step."
https://en.wikipedia.org/wiki?curid=15043
7,193
1,216,105
Early diagnosis of tumor malignancy is crucial for timely cancer treatment aimed at imparting desired clinical outcomes. The traditional fluorescence-based imaging is unfortunately faced with challenges such as low tissue penetration and background autofluorescence. Upconversion (UC)-based bioimaging can overcome these limitations as their excitation occurs at lower frequencies and the emission at higher frequencies. Kwon et al. developed multifunctional silica-based nanocapsules, synthesized to encapsulate two distinct triplet-triplet annihilation UC chromophore pairs. Each nanocapsule emits different colors, blue or green, following a red light excitation. These nanocapsules were further conjugated with either antibodies or peptides to selectively target breast or colon cancer cells, respectively. Both in vitro and in vivo experimental results demonstrated cancer-specific and differential-color imaging from single wavelength excitation as well as far greater accumulation at targeted tumor sites than that due to the enhanced permeability and retention effect. This approach can be used to host a variety of chromophore pairs for various tumor-specific, color-coding scenarios and can be employed for diagnosis of a wide range of cancer types within the heterogeneous tumor microenvironment.
https://en.wikipedia.org/wiki?curid=32253961
1,215,453
27,678
During the first decade or so of the public Internet, the immense changes it would eventually enable in the 2000s were still nascent. In terms of providing context for this period, mobile cellular devices ("smartphones" and other cellular devices) which today provide near-universal access, were used for business and not a routine household item owned by parents and children worldwide. Social media in the modern sense had yet to come into existence, laptops were bulky and most households did not have computers. Data rates were slow and most people lacked means to video or digitize video; media storage was transitioning slowly from analog tape to digital optical discs (DVD and to an extent still, floppy disc to CD). Enabling technologies used from the early 2000s such as PHP, modern JavaScript and Java, technologies such as AJAX, HTML 4 (and its emphasis on CSS), and various software frameworks, which enabled and simplified speed of web development, largely awaited invention and their eventual widespread adoption.
https://en.wikipedia.org/wiki?curid=13692
27,668
966,378
It was estimated that the unit cost of each missile would be less than $5 million (equivalent to $ million in ), making them much cheaper than a Boeing B-52 Stratofortress bomber. Operating costs would also be low, as keeping them in readiness would be cheaper than a submarine or bomber, and comparable with a missile silo-based ICBM. Range would not be unlimited, but would be determined by the fuel load. Merkle calculated that a MW-day would burn about one gram of highly enriched uranium. A 490 MW reactor with 50 kilograms of uranium would therefore burn 1 percent of its fuel each day. Assuming that an accumulation of neutron poisons could be avoided, the missile could fly for several days. The success of the project depended upon a series of technological advances in metallurgy and materials science. Pneumatic motors necessary to control the reactor in flight had to operate while red-hot and in the presence of intense ionizing radiation. The need to maintain supersonic speed at low altitude and in all kinds of weather meant that the reactor, code-named "Tory", had to survive high temperatures and conditions that would melt the metals used in most jet and rocket engines.
https://en.wikipedia.org/wiki?curid=57684
965,868
1,778,029
Nano-FTIR was first described in 2005 in a patent by Ocelic and Hillenbrand as Fourier transform spectroscopy of tip-scattered light with an asymmetric spectrometer (i.e. the tip/sample placed inside one of the interferometer arms). The first realization of s-SNOM with FTIR was demonstrated in 2006 in the laboratory of F. Keilmann using a mid-infrared source based on a simple version of nonlinear difference-frequency generation (DFG). However, the mid-IR spectra in this realization were recorded using dual comb spectroscopy principles, yielding a discrete set of frequencies and thus demonstrating a multiheterodyne imaging technique rather than nano-FTIR. The first continuous spectra were recorded only in 2009 in the same laboratory using a supercontinuum IR beam also obtained by DFG in GaSe upon superimposing two pulsed trains emitted from Er-doped fiber laser. This source further allowed in 2011 for the first assessment of nanoscale-resolved spectra of SiC with excellent quality and spectral resolution. At the same time, Huth et al. in the laboratory of R. Hillenbrand used IR radiation from a simple glowbar source in combination with the principles of Fourier transform spectroscopy, to record IR spectra of p-doped Si and its oxides in a semiconductor device. In the same work the term nano-FTIR was first introduced. However, an insufficient spectral irradiance of glowbar sources limited the applicability of the technique to the detection of strongly-resonant excitations such phonons; and the early supercontinuum IR laser sources, while providing more power, had very narrow bandwidth (<300 cm). Further attempt to improve the spectral power, while retaining the large bandwidth of a glowbar source was made by utilizing the IR radiation from a high temperature argon arc source (also known as plasma source). However, due to lack of commercial availability and rapid development of the IR supercontinium laser sources, plasma sources are not widely utilized in nano-FTIR.
https://en.wikipedia.org/wiki?curid=52973193
1,777,027
1,451,472
The evolution of interactome complexity is delineated in a study published in "Nature". In this study it is first noted that the boundaries between prokaryotes, unicellular eukaryotes and multicellular eukaryotes are accompanied by orders-of-magnitude reductions in effective population size, with concurrent amplifications of the effects of random genetic drift. The resultant decline in the efficiency of selection seems to be sufficient to influence a wide range of attributes at the genomic level in a nonadaptive manner. The Nature study shows that the variation in the power of random genetic drift is also capable of influencing phylogenetic diversity at the subcellular and cellular levels. Thus, population size would have to be considered as a potential determinant of the mechanistic pathways underlying long-term phenotypic evolution. In the study it is further shown that a phylogenetically broad inverse relation exists between the power of drift and the structural integrity of protein subunits. Thus, the accumulation of mildly deleterious mutations in populations of small size induces secondary selection for protein–protein interactions that stabilize key gene functions, mitigating the structural degradation promoted by inefficient selection. By this means, the complex protein architectures and interactions essential to the genesis of phenotypic diversity may initially emerge by non-adaptive mechanisms.
https://en.wikipedia.org/wiki?curid=1075046
1,450,655
482,689
Cajun/zydeco, country, R&B, rock, and their fusion into "swamp pop", were influences in LeDoux's childhood. In high school, he was a disc jockey at the local radio station, KEUN, and the rhythm guitarist of two bands: the Deadbeats and the Countdowns. Although he remained an avid music fan in later life, he did not actively play guitar for many years. In 2004, LeDoux and NYU Biology Professor Tyler Volk began performing as a cover band for small parties around NYU, and in 2006 they formed The Amygdaloids. The original band also included Daniela Schiller, (then an NYU postdoctoral fellow), and graduate student Nina Curley. The band's lyrics, mostly written by LeDoux, are based on neuroscientific, psychological, and philosophical themes, and offer scholarly insights into the role of mind and brain in daily life. Their inaugural CD, Heavy Mental, was released in 2007. On their second CD, Theory of My Mind, LeDoux and Grammy winner Rosanne Cash sing "Crime of Passion" and "Mind over Matter", both written by LeDoux. In 2012, the band released All in Our Minds, an EP in which all songs had "mind" in their title. Anxious, a companion to LeDoux's book with the same title, was released in 2015 and explores some of the same scientific themes as the book, but through song. The band's unique focus on original songs about mind and brain has landed them considerable press. They play regularly in New York City, and have also performed in Washington DC, San Antonio TX, Indianapolis IN, Lafayette LA, and Montreal. LeDoux and Amygdaloids' bassist Colin Dempsey perform as an acoustic duo called So We Are.
https://en.wikipedia.org/wiki?curid=4275189
482,445
1,739,018
Information in FlyBase originates from a variety of sources ranging from large-scale genome projects to the primary research literature. These data types include mutant phenotypes; molecular characterization of mutant alleles; and other deviations, cytological maps, wild-type expression patterns, anatomical images, transgenic constructs and insertions, sequence-level gene models, and molecular classification of gene product functions. Query tools allow navigation of FlyBase through DNA or protein sequence, by gene or mutant name, or through terms from the several ontologies used to capture functional, phenotypic, and anatomical data. The database offers several different query tools in order to provide efficient access to the data available and facilitate the discovery of significant relationships within the database. Links between FlyBase and external databases, such as BDGP or modENCODE, provide opportunities for further exploration into other model organism databases and other resources of biological and molecular information. The FlyBase project is carried out by a consortium of "Drosophila" researchers and computer scientists at Harvard University and Indiana University in the United States, and University of Cambridge in the United Kingdom.
https://en.wikipedia.org/wiki?curid=8758178
1,738,041
190,437
The large sums of money being made and spent caused an upsurge in crime and illicit activity in towns along the pipeline route. This was exacerbated by the fact that police officers and state troopers resigned in large groups to become pipeline security guards at wages far in excess of those available in public-sector jobs. Fairbanks' Second Avenue became a notorious hangout for prostitutes, and dozens of bars operated throughout town. In 1975, the Fairbanks Police Department estimated between 40 and 175 prostitutes were working in the city of 15,000 people. Trouble was incited sometimes by prostitutes' pimps, who engaged in turf fights. In 1976, police responded to a shootout between warring pimps who wielded automatic firearms. By and large, however, the biggest police issue was the number of drunken brawls and fighting. On the pipeline itself, thievery was a major problem. Poor accounting and record keeping allowed large numbers of tools and large amounts of equipment to be stolen. The "Los Angeles Times" reported in 1975 that as many as 200 of Alyeska's 1,200 yellow-painted trucks were missing from Alaska and "scattered from Miami to Mexico City". Alyeska denied the problem and said only 20–30 trucks were missing. The theft problem was typified by pipeliners' practice of mailing empty boxes to pipeline camps. The boxes then would be filled with items and shipped out. After Alyeska ruled that all packages had to be sealed in the presence of a security guard, the number of packages being sent from camps dropped by 75 percent.
https://en.wikipedia.org/wiki?curid=197732
190,340
1,772,725
Also in 1895, William A. Hemphill, former Mayor of Atlanta, Georgia and at the time, business manager of the Atlanta Constitution, organized the Cotton States and International Exposition, described as an attempt to promote the American South to the world and showcase products and new technologies, as well as to encourage trade with Latin America. The Cotton States and International Exposition featured exhibits from several states including various innovations in agriculture and technology and industry. African-Americans were prominently featured as part of the Exposition, with Booker T. Washington of Tuskegee Institute delivering his keynote speech on September 18, 1895 known as the Atlanta Compromise that attempted to promote racial cooperation, and was called "one of the most important and influential speeches in American history." The "Negro Building" contained exhibits from various educational institutions such as Tuskegee and Hampton Institute as well as a number of models of inventions from African Americans, courtesy of the Patent Office. Among the models were Benjamin's Gong and Signal chair. It appears that she may have been trying to promote its use in private life, as it was described as being used "by a patient in a hospital, or one waiting in a railway station [who] can call an attendant from an adjacent room without making any noise. The inventor claims that but half or a third as many attendants will be needed and the quiet and comfort of patients and guests will greatly promoted."
https://en.wikipedia.org/wiki?curid=33737968
1,771,728
1,977,471
The Minutewomen got a new head coach in 2012–13 when Bill Wright took over for Chris Cobb, who had taken a coaching job in NCAA Division III with Williams College. Wright inherited a strong team that already included the aforementioned stars, along with key freshmen Ally Perdios and Jess Greenwood, and Penn State transfer Paige Harrington. By the end of the regular season, were ranked second only to Liberty. That bit of history was made possible by another: UMass' first-ever ECWHL tournament title, thanks to a 2–1 title game win over defending ACHA national champion Northeastern. An impressive journey at the ACHA National Tournament in Ashburn, Virginia followed, with an opening 3–2 win over 2011 national champ Michigan State, as second-period goals from Oteri, Labossiere and Chelsea Bräm turned around an early 2–0 deficit. Although Northeastern took an ECWHL final rematch in the day one nightcap (the first day of the tournament involved two pool games played by each team at the time), two more Oteri goals delivered a vital 2–1 victory over Robert Morris (IL) that, along with tiebreaker help, sent UMass through to the semifinals for the third time in program history. Once there, however, eventual champ Minnesota jumped on the Minutemen for three goals in the first ten minutes of the contest en route to a 5–1 result.
https://en.wikipedia.org/wiki?curid=54095645
1,976,333
1,237,175
Ferranti followed up on the ULA Designer with the Silicon Design System product based on the VAX-11/730 with 1 MB of RAM, 120 MB Winchester disk, and utilising a high-resolution display driven by a graphics unit with 500 KB of its own memory for "high speed windowing, painting, and editing capabilities". The software itself was available separately for organisations already likely to be using VAX-11/780 systems to provide a multi-user environment, but the "standalone system" package of hardware and software was intended to provide a more affordable solution with a "faster response" during the design process. The suite of tools involved in the use of the product included logic entry and test schedule definition (using Ferranti's own description languages), logic simulation, layout definition and checking, and mask generation for prototype gate arrays. The system also sought to support completely auto-routed designs, utilising architectural features of Ferranti's auto-routable (AR) arrays to deliver a "100-percent success auto-layout system" with this convenience incurring an increase in silicon area of approximately 25 percent.
https://en.wikipedia.org/wiki?curid=592816
1,236,511
1,497,105
Many of these women were in the World Championship race and the world record run before it. They had a year to think about and prepare their way to beat Dibaba. The final started off in a walk for these athletes, the first lap in 1:16.57. Dibaba went almost to the back of the pack, with the last chaser in her previous major races, Sifan Hassan watching her back and only Laura Muir trailing. Shannon Rowbury was relegated to the unwanted leader duties until Laura Weightman moved forward near the end of the lap. After the slow first lap, even Muir tired of jogging at the back and moved forward, but not Dibaba and Hassan. By the steeplechase pit, 550 metres into the race, Dibaba ran a few quicker steps and moved to the outside, foretelling her move. Over the next 150 metres, Dibaba floated forward with ease, Hassan following. Over the next 100 metres, Dibaba cruised to the front, with each of the key figures in the race recognizing she had passed and scrambling to follow. With a lap and a half to go, Muir was tight on Dibaba's shoulder, followed by Faith Kipyegon, Besu Sado, Jennifer Simpson, Hassan and Rowbury. Dawit Seyaum came up from behind to join the mix of leaders but all were fighting not to let Dibaba get away. At the bell, Kipyegon had gotten around Muir and was right on Dibaba's back, a gap had separated between Muir and the next chaser, Hassan. The third lap was run in 56.80. Both Dibaba and Kipyegon appeared to be in full sprint, but Kipyegon stuck to Dibaba like glue down the backstretch. Then with just over 200 to go, Kipyegon accelerated around Dibaba. Dibaba had no answer. Kipyegon continued to extend her lead on to the finish line. Behind them was the battle for bronze. With 150 to go, Hassan caught Muir but Simpson was right on her back and Rowbury was gaining from behind. Coming off the turn, Simpson went into her sprint, which left Hassan behind. Rowbury also ran past Hassan and followed Simpson to the line. Dibaba tied up badly going in to the finish, with Simpson rapidly gaining, but the finish line arrived for Dibaba faster than a sprinting Simpson could get there.
https://en.wikipedia.org/wiki?curid=45151369
1,496,262
368,359
While the mechanisms of genetic predisposition remain unclear, a few genetic factors have been found to increase susceptibility to autoimmune reactions in RHD. The dominant contributors are a component of MHC class II molecules, found on lymphocytes and antigen-presenting cells, specifically the DR and DQ alleles on human chromosome 6. Certain allele combinations appear to increase RHD autoimmune susceptibility. Human leukocyte antigen (HLA) class II allele DR7 (HLA-DR7) is most often associated with RHD, and its combination with certain DQ alleles is seemingly associated with the development of valvular lesions. The mechanism by which MHC class II molecules increase a host's susceptibility to autoimmune reactions in RHD is unknown, but it is likely related to the role HLA molecules play in presenting antigens to T cell receptors, thus triggering an immune response. Also found on human chromosome 6 is the cytokine TNF-α which is also associated with RHD. High expression levels of TNF-α may exacerbate valvular tissue inflammation, because as this cytokine circulates in the bloodstream, it triggers the activation of multiple pathways that stimulate further pro-inflammatory cytokine secretion. Mannose-binding lectin (MBL) is an inflammatory protein involved in pathogen recognition. Different variants of MBL2 gene regions are associated in RHD. RHD-induced mitral valve stenosis has been associated with MBL2 alleles encoding for high production of MBL. Aortic valve regurgitation in RHD patients has been associated with different MBL2 alleles that encode for low production of MBL. In addition, the allele IGHV4-61, located on chromosome 14, which helps code for the immunoglobulin heavy chain (IgH) is linked to greater susceptibility to RHD because it may affect protein structure of the IgH. Other genes are also being investigated to better understand the complexity of autoimmune reactions that occur in RHD.
https://en.wikipedia.org/wiki?curid=412735
368,166
1,133,589
Environmental protection became a national priority in the 1970s. "Time" magazine declared it the Issue of the Year in January 1971, reporting that it was rated as Americans' "most serious problem confronting their community—well ahead of crime, drugs and poor schools". When South Florida experienced a severe drought from 1970 to 1975, with Miami receiving only of rain in 1971— less than average—media attention focused on the Everglades. With the assistance of governor's aide Nathaniel Reed and U.S. Fish and Wildlife Service biologist Arthur R. Marshall, politicians began to take action. Governor Reubin Askew implemented the Land Conservation Act in 1972, allowing the state to use voter-approved bonds of $240 million to purchase land considered to be environmentally unique and irreplaceable. Since then, Florida has purchased more land for public use than any other state. In 1972 President Richard Nixon declared the Big Cypress Swamp—the intended location for the Miami jetport in 1969—to be federally protected. Big Cypress National Preserve was established in 1974, and Fakahatchee Strand State Preserve was created the same year.
https://en.wikipedia.org/wiki?curid=17601646
1,132,996
622,126
After returning to the patrol area with the wolf pack, she made an unsuccessful attack on a transport on 3 November. The following day, "Sailfish" damaged the Japanese destroyer Harukaze and Japanese landing ship T-111 (890 tons) in Luzon Strait in position 20°08'N, 121°43'E but was slightly damaged herself by a bomb from a patrol aircraft. With battle damage under control, "Sailfish" eluded her pursuers and cleared the area. After riding out a typhoon on 9–10 November, she intercepted a convoy on the evening of 24 November heading for Itbayat in the Philippines. After alerting "Pomfret" of the convoy's location and course, "Sailfish" was moving into an attack position when one of the escorting destroyers headed straight for her. "Sailfish" fired a three-torpedo spread "down the throat" and headed toward the main convoy. At least one hit was scored on the destroyer and her pip faded from the radar screen. Suddenly, "Sailfish" received an unwelcome surprise when she came under fire from the destroyer that she had believed to be sunk. "Sailfish" ran deep after ascertaining there was no hull damage resulting from a near miss from the escort's guns. For the next 4 hours, "Sailfish" was forced to run silent and deep as the Japanese kept up an uncomfortably accurate depth charge attack. Finally, the submarine was able to elude the destroyers and slip away. Shortly, "Sailfish" headed for Hawaii, via Midway, and completed her 12th and final war patrol upon arriving at Pearl Harbor on 11 December. "Sailfish" had damaged the IJN destroyer , which had previously sunk , and also a landing ship.
https://en.wikipedia.org/wiki?curid=422293
621,794
1,250,832
Montgomery was educated at Plymouth College. He obtained a 1st Class BSc degree in 1984 in neuropharmacology and cardiorespiratory physiology, before qualifying as a medical doctor in July 1987 from the Middlesex Hospital Medical School, University of London. He was awarded the prize as most outstanding student during this time. In 1997, he was awarded his higher research degree (MDRes) for work on paracrine renin-angiotensin systems. He now directs the UCL centre for Human Health and Performance. He has authored nearly 500 research papers in journals such as "Nature", "The Lancet" and the "New England Journal of Medicine". and has received 11 national and international awards. His work has ranged from the development and application of gene-environment interaction studies (reporting the 'first gene for human physical performance'), to population genetic studies (being amongst the first to identify signatures of selection for high altitude amongst Tibetans) and work in artificial intelligence. He was research lead for the 2008 Xtreme Everest research expedition. He co-chairs the Lancet Countdown on Health and Climate Change, having co-chaired several previous commissions on the subject.
https://en.wikipedia.org/wiki?curid=20863054
1,250,156
455,618
Recently, highly precise astrometry of extragalactic objects using both Very Long Baseline Interferometry and the "Gaia" space observatory have successfully measured this small effect. The first VLBI measurement of the apparent motion, over a period of 20 years, of 555 extragalactic objects towards the center of our galaxy at equatorial coordinates of α = 263° and δ = −20° indicated a secular aberration drift 6.4 ±1.5 μas/yr. Later determinations using a series of VLBI measurements extending over almost 40 years determined the secular aberration drift to be 5.83 ± 0.23 μas/yr in the direction α = 270.2 ± 2.3° and δ = −20.2° ± 3.6°. Optical observations using only 33 months of "Gaia" satellite data of 1.6 million extragalactic sources indicated an acceleration of the solar system of 2.32 ± 0.16 × 10 m/s and a corresponding secular aberration drift of 5.05 ± 0.35 µas/yr in the direction of α = 269.1° ± 5.4°, δ = −31.6° ± 4.1°. It is expected that later "Gaia" data releases, incorporating about 66 and 120 months of data, will reduce the random errors of these results by factors of 0.35 and 0.15. The latest edition of the International Celestial Reference Frame (ICRF3) adopted a recommended galactocentric aberration constant of 5.8 µas/yr and recommended a correction for secular aberration to obtain the highest positional accuracy for times other than the reference epoch 2015.0.
https://en.wikipedia.org/wiki?curid=2703
455,396
1,661,645
Landfill gas can be converted to high-Btu gas by reducing its carbon dioxide, nitrogen, and oxygen content. The high-Btu gas can be piped into existing natural gas pipelines or in the form of CNG (compressed natural gas) or LNG (liquid natural gas). CNG and LNG can be used on site to power hauling trucks or equipment or sold commercially. Three commonly used methods to extract the carbon dioxide from the gas are membrane separation, molecular sieve, and amine scrubbing. Oxygen and nitrogen are controlled by the proper design and operation of the landfill since the primary cause for oxygen or nitrogen in the gas is intrusion from outside into the landfill because of a difference in pressure. The high-Btu processing equipment can be expected to cost $2,600 to $4,300 per standard cubic foot per minute (scfm) of landfill gas. Annual costs range from $875,000 to $3.5 million to operate, maintain and provide electricity to. Costs depend on quality of the end product gas as well as the size of the project. The first landfill gas to LNG facility in the United States was the Frank R. Bowerman Landfill in Orange County, California. The same process is used for the conversion to CNG, but on a smaller scale. The CNG project at Puente Hills Landfill in Los Angeles has realized $1.40 per gallon of gasoline equivalent with the flow rate of 250 scfm. Cost per gallon equivalent reduces as the flow rate of gas increases. LNG can be produced through the liquification of CNG. However, the oxygen content needs to be reduced to be under 0.5% to avoid explosion concerns, the carbon dioxide content must be as close to zero as possible to avoid freezing problems encountered in the production, and nitrogen must be reduced enough to achieve at least 96% methane. A $20 million facility is estimated to achieve $0.65/gallon for a plant producing 15,000 gallons/day of LNG (3,000 scfm). Estimates are in 2007 dollars.
https://en.wikipedia.org/wiki?curid=25249780
1,660,710
1,099,081
Although India still has low average incomes per person, the country is now the third largest emitter of greenhouse gas emissions after China and the USA. The central government has pledged to reduce the emission intensity of Gross Domestic Product by 20-25%, relative to 2005 levels, by 2020. India has also made major pledges to expand its renewable energy supply, enhance energy efficiency, build mass transit and other measures to reduce its emissions. There is evidence that many of these climate actions could generate substantial benefits in addition to reducing India's carbon footprint. Many low-carbon measures are economically attractive, including more efficient air conditioners, parking demand management, gasification and vehicle performance standards. Others offer social benefits: for example, Indian cities might see substantial improvements in air quality if the country were to promote renewable energy technologies instead of fossil fuels and walking/cycling/public transport instead of private vehicles.
https://en.wikipedia.org/wiki?curid=15988807
1,098,521
116,208
Some prototype RTGs, first built in 1958 by the US Atomic Energy Commission, have used polonium-210. This isotope provides phenomenal power density (pure Po emits 140 W/g) because of its high decay rate, but has limited use because of its very short half-life of 138 days. A half-gram sample of Po reaches temperatures of over . As Po-210 is a pure alpha-emitter and does not emit significant gamma or X-ray radiation, the shielding requirements are also low as for Pu-238. While the short half-life also reduces the time during which accidental release to the environment is a concern, Polonium-210 is extremely radiotoxic if ingested and can cause significant harm even in chemically inert forms, which pass through the digestive tract as a "foreign object". A common route of production (whether accidental or deliberate) is neutron irradiation of , the only naturally occurring isotope of Bismuth. It is this accidental production that is cited as an argument against the use of lead-bismuth eutectic as a coolant in liquid metal reactors. However, if a sufficient demand for Polonium-210 exists, its extraction could be worthwhile similar to how tritium is economically recovered from the heavy water moderator in CANDUs.
https://en.wikipedia.org/wiki?curid=211485
116,163
155,677
, or Production Model, is the first Evangelion specimen researched and designed for eventual mass production and actual combat. Although the conception and construction of the machine takes place in Japan, the assembly and activation experiments, as well as the training of its pilot, the Second Child Asuka Langley Soryu, are performed in Germany. The biological material used for its creation belongs to Adam. A decisive part in the development and activation of the unit is played by Dr. Kyōko Zeppelin Sōryū, a member of the German section of Gehirn. Kyōko offers herself as a guinea pig for the experiment to activate the Evangelion, from which she comes out psychologically distraught. It is speculated that a part of her soul, or her "maternal side", remained locked inside the 02. In contrast to the first two units, it has four eyes, a feature that is abandoned in later models. Additional features that distinguish the 02 concern the color of the internal fluids of the humanoid body, blue instead of red as in the case of previous units, and the presence of new mechanical details.
https://en.wikipedia.org/wiki?curid=577372
155,606
1,528,106
OGCMs have many important applications: dynamical coupling with the atmosphere, sea ice, and land run-off that in reality jointly determine the oceanic boundary fluxes; transpire of biogeochemical materials; interpretation of the paleoclimate record;climate prediction for both natural variability and anthropogenic chafes; data assimilation and fisheries and other biospheric management. OGCMs play a critical role in Earth system model. They maintain the thermal balance as they transport energy from tropical to the polar latitudes. To analyze the feedback between ocean and atmosphere we need ocean model, which can initiate and amplify climate change on many different time scales, for instance, the interannual variability of El Niño and the potential modification of the major patterns for oceanic heat transport as a result of increasing greenhouse gases. Oceans are a kind of undersampled nature fluid system, so by using OGCMs we can fill in those data blank and improve understanding of basic processes and their interconnectedness, as well as to help interpret sparse observations. Even though, simpler models can be used to estimate climate response, only OGCM can be used conjunction with atmospheric general circulation model to estimate global climate change.
https://en.wikipedia.org/wiki?curid=41244624
1,527,242
895,879
Environmental psychology was not fully recognized as its own field until the late 1960s when scientists began to question the tie between human behavior and our natural and built environments. Since its conception, the field has been committed to the development of a discipline that is both value oriented and problem oriented, prioritizing research aimed at solving complex environmental problems in the pursuit of individual well-being within a larger society. When solving problems involving human-environment interactions, whether global or local, one must have a model of human nature that predicts the environmental conditions under which humans will respond well. This model can help design, manage, protect and/or restore environments that enhance reasonable behavior, predict the likely outcomes when these conditions are not met, and diagnose problem situations. The field develops such a model of human nature while retaining a broad and inherently multidisciplinary focus. It explores such dissimilar issues as common property resource management, wayfinding in complex settings, the effect of environmental stress on human performance, the characteristics of restorative environments, human information processing, and the promotion of durable conservation behavior. Lately, alongside the increased focus on climate change in society and the social sciences and the re-emergence of limits-to-growth concerns, there has been an increased focus on environmental sustainability issues within the field.
https://en.wikipedia.org/wiki?curid=1639997
895,408
983,905
Humboldt State Normal School was established as a teacher's college on June 16, 1913, by then-California Governor, Hiram Johnson. It was named after the famous German scientist Alexander von Humboldt. The cities of Arcata and Eureka (and to a lesser extent Fortuna) competed with one another to host the new campus. Arcata eventually won the university when William Preston, and the Union Water company, donated 55-acres. It opened on April 6, 1914, in the former Arcata Grammar School building with 78 students and 5 faculty. On May 26, 1915, the first commencement of the first graduating class occurred, a class of 15 women. The first graduate awarded their degree in 1915 was local historian Susie Baker Fountain, who went on to catalog much of Humboldt County history from 1850 to 1966. Baker was a columnist for the Blue Lake Advocate and her extraordinary, lifelong collection of newspaper clippings and images are available for viewing in HSU Special Collections.
https://en.wikipedia.org/wiki?curid=197004
983,391
237,763
The aurochs was widespread across Eurasia, North Africa, and the Indian subcontinent during the Pleistocene, but only the European aurochs ("Bos primigenius primigenius") survived into historical times. This species is heavily featured in European cave paintings, such as Lascaux and Chauvet cave in France, and was still widespread during the Roman era. Following the fall of the Roman empire, overhunting of the aurochs by nobility caused its population to dwindle to a single population in the Jaktorów forest in Poland, where the last wild one died in 1627. However, because the aurochs is ancestral to most modern cattle breeds, it is possible for it to be brought back through selective or back breeding. The first attempt at this was by Heinz and Lutz Heck using modern cattle breeds, which resulted in the creation of Heck cattle. This breed has been introduced to nature preserves across Europe; however, it differs strongly from the aurochs in physical characteristics, and some modern attempts claim to try to create an animal that is nearly identical to the aurochs in morphology, behavior, and even genetics. There are several projects that aim to create a cattle breed similar to the aurochs through selectively breeding primitive cattle breeds over a course of twenty years to create a self-sufficient bovine grazer in herds of at least 150 animals in rewilded nature areas across Europe, for example the Tauros Programme and the Taurus Project. This organization is partnered with the organization Rewilding Europe to help restore balance to European nature. A competing project to recreate the aurochs is the Uruz Project by the True Nature Foundation, which aims to recreate the aurochs through a more efficient breeding strategy and through genome editing, in order to decrease the number of generations of breeding needed and the ability to quickly eliminate undesired traits from the aurochs-like cattle population. It is hoped that aurochs-like cattle will reinvigorate European nature by restoring its ecological role as a keystone species, and bring back biodiversity that disappeared following the decline of European megafauna, as well as helping to bring new economic opportunities related to European wildlife viewing.
https://en.wikipedia.org/wiki?curid=39379960
237,644
54,358
Large, heavily protected underground factories were constructed – as with the partly-buried Weingut I complex for Jumo 004 jet engine production – to take up production of the Me 262, safe from bomb attacks. A disused mine complex under the Walpersberg mountain was adapted for the production of complete aircraft. These were hauled to the flat top of the hill where a runway had been cleared and flown out. Between 20 and 30 Me 262s were built here, the underground factory being overrun by Allied troops before it could reach a meaningful output. Wings were produced in Germany's oldest motorway tunnel at Engelberg, to the west of Stuttgart. At "B8 Bergkristall-Esche II", a vast network of tunnels was excavated beneath St. Georgen/Gusen, Austria, where slave labourers of concentration camp Gusen II produced fully equipped fuselages for the Me 262 at a monthly rate of 450 units on large assembly lines from early 1945. Gusen II was known as one of the harshest concentration camps; the typical life expectancy was six months. An estimated 35,000 to 50,000 people died on the forced labour details for the Me 262.
https://en.wikipedia.org/wiki?curid=20488
54,338
495,003
The extract of the liana Banisteriopsis caapi has been used by the tribes of the Amazon as an entheogen and was described as a hallucinogen in the middle of the 19th century. In early 20th century, European pharmacists identified harmine as the active substance. This discovery stimulated the interest to further investigate its potential as a medicine. For example, Louis Lewin, a prominent pharmacologist, demonstrated a dramatic benefit in neurological impairments after injections of "B. caapi" in patients with postencephalitic Parkinsonism. By 1930, it was generally agreed that hypokinesia, drooling, mood, and sometimes rigidity improved by treatment with harmine. Altogether, 25 studies had been published in the 1920s and 1930s about patients with Parkinson's disease and postencephalitic Parkinsonism. The pharmacological effects of harmine have been attributed mainly to its central monoamine oxidase (MAO) inhibitory properties. In-vivo and rodent studies have shown that extracts of "Banisteriopsis caapi" and also "Peganum harmala" lead to striatal dopamine release. Furthermore, harmine supports the survival of dopaminergic neurons in MPTP-treated mice. Since harmine also antagonizes "N"-methyl-d-aspartate (NMDA) receptors, some researchers speculatively attributed the rapid improvement in patients with Parkinson's disease to these antiglutamatergic effects. However, the advent of synthetic anticholinergic drugs at that time led to the total abandonment of harmine.
https://en.wikipedia.org/wiki?curid=608186
494,747
2,057,950
The long Trans-Iranian Railway from Bandar Shah on the Caspian Sea to Bandar Shahpur on the Persian Gulf was opened during the reign of Reza Shah Pahlavi in 1939. The railroad was built with rail weighing 67 pounds per yard (33 kg/m) and required more than 3000 bridges. There were 126 tunnels in the Zagros mountains. The longest was 1.5 miles. Grades averaged 1.5 percent south of Tehran, but then increased to 2.8 percent to cross the 7,270-foot pass between Tehran and the Caspian Sea. After the Anglo-Soviet invasion of Iran in 1941, this Persian Corridor became one of the supply routes for war material for the Soviet Union during World War II, (Railway trend in Iran). The British built a branch line from the 3000-foot (900-meter) bridge over the Karun River in Ahwaz to a new southern port at Khorramshahr on the Shatt al-Arab river. In 1943 3,473 American soldiers of the Military Railway Service began running trains between the Persian Gulf and Caspian Sea using ALCO RS-1 locomotives rebuilt with 3-axle trucks and designated RSD-1. The Americans set up headquarters in Ahwaz, but were unable to tolerate the daytime heat, and generally operated the railway at night.
https://en.wikipedia.org/wiki?curid=38693593
2,056,765
791,843
Study has proceeded more slowly in three-dimensional than in two-dimensional photonic crystals. This is because of more difficult fabrication. Three-dimensional photonic crystal fabrication had no inheritable semiconductor industry techniques to draw on. Attempts have been made, however, to adapt some of the same techniques, and quite advanced examples have been demonstrated, for example in the construction of "woodpile" structures constructed on a planar layer-by-layer basis. Another strand of research has tried to construct three-dimensional photonic structures from self-assembly—essentially letting a mixture of dielectric nano-spheres settle from solution into three-dimensionally periodic structures that have photonic band-gaps. Vasily Astratov's group from the Ioffe Institute realized in 1995 that natural and synthetic opals are photonic crystals with an incomplete bandgap. The first demonstration of an "inverse opal" structure with a complete photonic bandgap came in 2000, from researchers at the University of Toronto, Canada, and Institute of Materials Science of Madrid (ICMM-CSIC), Spain. The ever-expanding field of natural photonics, bioinspiration and biomimetics—the study of natural structures to better understand and use them in design—is also helping researchers in photonic crystals. For example, in 2006 a naturally occurring photonic crystal was discovered in the scales of a Brazilian beetle. Analogously, in 2012 a diamond crystal structure was found in a weevil and a gyroid-type architecture in a butterfly. More recently, gyroid photonic crystals have been found in the feather barbs of blue-winged leafbirds and are responsible for the bird's shimmery blue coloration.
https://en.wikipedia.org/wiki?curid=355377
791,418
369,797
Carl Linnaeus in 1753 regarded the Brassicaceae as a natural group, naming them "Klass" Tetradynamia. Alfred Barton Rendle placed the family in the order Rhoedales, while George Bentham and Joseph Dalton Hooker in their system published from 1862–1883, assigned it to their cohort Parietales (now the class Violales). Following Bentham and Hooker, John Hutchinson in 1948 and again in 1964 thought the Brassicaceae to stem from near the Papaveraceae. In 1994, a group of scientists including Walter Stephen Judd suggested to include the Capparaceae in the Brassicaceae. Early DNA-analysis showed that the Capparaceae—as defined at that moment—were paraphyletic, and it was suggested to assign the genera closest to the Brassicaceae to the Cleomaceae. The Cleomaceae and Brassicaceae diverged approximately 41 million years ago. All three families have consistently been placed in one order (variably called Capparales or Brassicales). The APG II system merged Cleomaceae and Brassicaceae. Other classifications have continued to recognize the Capparaceae, but with a more restricted circumscription, either including "Cleome" and its relatives in the Brassicaceae or recognizing them in the segregate family Cleomaceae. The APG III system has recently adopted this last solution, but this may change as a consensus arises on this point. Current insights in the relationships of the Brassicaceae, based on a 2012 DNA-analysis, are summarized in the following tree.
https://en.wikipedia.org/wiki?curid=3794
369,603
790,724
Some animal phyla have gone through major brain enlargement through evolution (e.g. vertebrates and cephalopods both contain many lineages in which brains have grown through evolution) but most animal groups are composed only of species with extremely small brains. Some scientists argue that this difference is due to vertebrate and cephalopod neurons having evolved ways of communicating that overcome the scalability problem of neural networks while most animal groups have not. They argue that the reason why traditional neural networks fail to improve their function when they scale up is because filtering based on previously known probabilities cause self-fulfilling prophecy-like biases that create false statistical evidence giving a completely false worldview and that randomized access can overcome this problem and allow brains to be scaled up to more discriminating conditioned reflexes at larger brains that lead to new worldview forming abilities at certain thresholds. This means when neurons scale in a non randomized fashion that their functionality becomes more limited due to their neural networks being unable to process more complex systems without the exposure to new formations. This is explained by randomization allowing the entire brain to eventually get access to all information over the course of many shifts even though instant privileged access is physically impossible. They cite that vertebrate neurons transmit virus-like capsules containing RNA that are sometimes read in the neuron to which it is transmitted and sometimes passed further on unread which creates randomized access, and that cephalopod neurons make different proteins from the same gene which suggests another mechanism for randomization of concentrated information in neurons, both making it evolutionarily worth scaling up brains.
https://en.wikipedia.org/wiki?curid=17682224
790,299
1,717,738
tolerable burden if compared to the US, today's global superpower, which spent 3.8% of its GDP on defence in 2006 (18% of the federal budget). But the comparison is misleading. Due to modern technology, a modern economy is far more productive per capita than the Roman economy: on one estimate, the average American in 1998 was at least 73 times more economically productive, in comparable terms (i.e. in international dollars), than a Roman in the 1st century AD. Another factor to consider is that half the population was 25 or less (compare modern societies 35-40) meaning that larger portion of the population were too young and not taxpayers. Another factor is that many items of production were not taxed such as those for domestic use, clothing, buildings. Therefore, taxes (and compulsory services) to support the Roman military would have taken a much greater share of surplus per capita production i.e. surplus to the subsistence needs of producers, almost all agricultural. For the average peasant, the taxes and services he was obliged to provide to the military would have represented a significant share of his disposable surplus if situated within reasonable distance of the units. Compulsory services performed by the richer members of society helped to supply military needs (and maintain the infrastructures of cities and the empire, in effect a tax that was paid for in money or labor).
https://en.wikipedia.org/wiki?curid=16058452
1,716,769
232,181
In mid-July 1941, the 3rd Panzer Group was subordinated to Army Group North to shore up the flanks and attempted to seize Velikie Luki. This was part of a larger operation aimed at seizing Leningrad. Hoth's forces were driven back on 20 July when Red Army forces broke through the German lines, prompting criticism from Bock for unnecessarily striking out too far to the north east. In early August, Hitler ordered a southward diversion of the German advance at Bryansk to the objection of many leading German officers, including Hoth, who advocated for a continued direct drive to Moscow. In mid to late August, Hoth's forces faced another setback owing to heavy losses and dispersal of efforts: facing the heavily reinforced Soviet 19th Army, he committed the 7th Panzer Division without infantry support, which resulted in what the historian David Stahel describes as a "debacle". The division's attack ran into fortified Soviet lines and was repulsed with the loss of 30 tanks. By September, the constant fighing had heavily depleted Hoth's force, as the 3rd Panzer Group had only about 250 tanks remaining. Hoth's panzer group subsequently assisted in Operation Typhoon, the offensive to capture Moscow. Stationed on the left flank, his force and the 9th Army were supposed to attack from Dukhovshchina toward Vyazma. As the plans for Operation Typhoon were discussed by the OKH and frontline commanders, Hoth argued for a delay of one day regarding the offensive, but was overruled.
https://en.wikipedia.org/wiki?curid=261665
232,062
1,779,310
The US needed data to overcome the tropical littoral challenges in the SCS, so the entire experiment was funded by the Office of Naval Research (ONR) but lead by the Academia to camouflage the strategic intent. ASIAEX was only the beginning, and the US government routinely undertook acoustic data collection post that by streaming acoustic arrays and deploying underwater drones in the SCS. The Chinese realized and accepted their limitation of undertaking such large scale SWAM experiments so participated with the Americans to learn. They followed it up with massive drive culminating in the Underwater Great Wall project. In Dec 2016 the Chinese seized a US underwater drone deployed from USNS Bowditch. The incident was an official declaration by the Chinese that they are now confident of taking forward their own acoustic development program. The Malaysia Airlines Flight 370 accident and the subsequent search operation was another geopolitical exercise to corner China and its acoustic capability and capacity development initiative by the west. Malaysia Airlines Flight 370 had more than 90% Chinese passengers and China was very keen to lead the search operation in the IOR, but the role was assigned to Australia, which possibly had no direct stake in the event. The massive acoustic capacity and capability development that happened during the three-year search operations with global funding was denied to China. Acoustic capacity and capability development in the tropical littoral can only happen with massive SWAM experimental initiatives. These are extremely resource intensive and need to be funded at a different scale and also supported with cutting-edge technology support both for hardware and software. The pooling of resources and synergizing of effort is inescapable both at the national and regional level.
https://en.wikipedia.org/wiki?curid=60878831
1,778,307
1,458,562
His current research interests include the physics of the early Universe, the nature of physical complexity, and questions related to the origin of life on Earth and elsewhere in the Universe. He has contributed seminal ideas in the interface between particle physics and cosmology, in particular on the dynamics of phase transitions and spontaneous symmetry breaking. He is the co-discoverer of "oscillons," time-dependent long-lived field configurations which are present in many physical systems from cosmology to vibrating grains. In 2012, he pioneered the use of concepts from information theory as a measure of complexity in nature. The author of over one hundred papers in peer-reviewed journals, Gleiser has also published five popular science books in the US: "The Simple Beauty of the Unexpected" (2016), "The Island of Knowledge" (2014), "A Tear at the Edge of Creation" (2010), "The Prophet and the Astronomer" (2002), and "The Dancing Universe" (1997/2005). Translated in over 15 languages, Gleiser's books offer a uniquely broad cultural view of science and its relation with religion and philosophy. "The Simple Beauty of the Unexpected", "The Prophet and the Astronomer" and "The Dancing Universe" won the Jabuti Award for best nonfiction in Brazil.
https://en.wikipedia.org/wiki?curid=2406519
1,457,742
748,302
Modern plant breeding, whether classical or through genetic engineering, comes with issues of concern, particularly with regard to food crops. The question of whether breeding can have a negative effect on nutritional value is central in this respect. Although relatively little direct research in this area has been done, there are scientific indications that, by favoring certain aspects of a plant's development, other aspects may be retarded. A study published in the "Journal of the American College of Nutrition" in 2004, entitled "Changes in USDA Food Composition Data for 43 Garden Crops, 1950 to 1999", compared nutritional analysis of vegetables done in 1950 and in 1999, and found substantial decreases in six of 13 nutrients measured, including 6% of protein and 38% of riboflavin. Reductions in calcium, phosphorus, iron and ascorbic acid were also found. The study, conducted at the Biochemical Institute, University of Texas at Austin, concluded in summary: ""We suggest that any real declines are generally most easily explained by changes in cultivated varieties between 1950 and 1999, in which there may be trade-offs between yield and nutrient content.""
https://en.wikipedia.org/wiki?curid=30876044
747,904
328,787
Whereas the older "depth scales" tried to infer the level of "hypnotic trance" from supposed observable signs such as spontaneous amnesia, most subsequent scales have measured the degree of observed or self-evaluated "responsiveness" to specific suggestion tests such as direct suggestions of arm rigidity (catalepsy). The Stanford, Harvard, HIP, and most other susceptibility scales convert numbers into an assessment of a person's susceptibility as "high", "medium", or "low". Approximately 80% of the population are medium, 10% are high, and 10% are low. There is some controversy as to whether this is distributed on a "normal" bell-shaped curve or whether it is bi-modal with a small "blip" of people at the high end. Hypnotisability Scores are highly stable over a person's lifetime. Research by Deirdre Barrett has found that there are two distinct types of highly susceptible subjects, which she terms fantasisers and dissociaters. Fantasisers score high on absorption scales, find it easy to block out real-world stimuli without hypnosis, spend much time daydreaming, report imaginary companions as a child, and grew up with parents who encouraged imaginary play. Dissociaters often have a history of childhood abuse or other trauma, learned to escape into numbness, and to forget unpleasant events. Their association to "daydreaming" was often going blank rather than creating vividly recalled fantasies. Both score equally high on formal scales of hypnotic susceptibility.
https://en.wikipedia.org/wiki?curid=14417
328,613
1,819,865
In 1964, he moved to The University of Chicago, where he has worked on atomic and ionic collision processes, photoionization, the nature of correlation of valence electrons in atoms, and, more recently, on atomic and molecular clusters, and on protein dynamics. He became interested in energy and its efficient use first through concern about Chicago's air pollution in the 1960s. This led to what we believe is one of the first public studies of what has become called "life cycle analysis." This was an analysis of the actual and ideal limiting energy and free energy use in the manufacture and disposal of the automobile, and was carried out with Margaret F. Fels. This led to many other such analyses, which now are done very frequently. This work, in turn, stimulated what has become known as "finite-time thermodynamics," the study of the optimal performance of processes constrained to operate in finite time or at nonzero rates. He has been very active in the study of atomic and molecular clusters, particularly in their phases and phase changes. This has led to a broader interest in bridging between the microscopic and macroscopic descriptions of physical systems, especially of finding the boundary below which a macroscopic description fails.
https://en.wikipedia.org/wiki?curid=660207
1,818,830
2,215,753
The Falcons returned after the winter break with a much more concerted defensive effort and ran a winning streak to 6 games. After dropping a weekend to Canisius in mid-January, Air Force won 9 of their next 11 games. The extended period of success allowed the Falcons to regain a spot in the polls and gave them a chance at winning the Atlantic Hockey title. Entering the final weekend of the regular season, they needed four points to get past Canisius or three to split the regular season title. The Falcons blew out Canisius 5–0 in the first game, leaving them one point behind the Griffins. While they were hoping for a repeat performance in the season finale, the Pioneer netminder, Nathan Perry, stopped 39 Falcon shots. That still left Air Force in the lead by a 2–1 score with about a minute to play. After pulling their goaltender, SHU managed to tie the game with 53 seconds left. In the overtime, Air Force was given a gift when Sacred Heart took a penalty at the 50 second mark. The Falcons were unable to get on track during the power play and failed to record a shot on goal. Instead, the Pioneers were able to get Starrett to take an unsportsmanlike penalty and even the playing field. Just 4 seconds after the ensuing faceoff, the puck found its way into the Air Force net and the Falcons were relegated to 2nd-place.
https://en.wikipedia.org/wiki?curid=70000301
2,214,493
1,039,614
In general, expression profiling studies report those genes that showed statistically significant differences under changed experimental conditions. This is typically a small fraction of the genome for several reasons. First, different cells and tissues express a subset of genes as a direct consequence of cellular differentiation so many genes are turned off. Second, many of the genes code for proteins that are required for survival in very specific amounts so many genes do not change. Third, cells use many other mechanisms to regulate proteins in addition to altering the amount of mRNA, so these genes may stay consistently expressed even when protein concentrations are rising and falling. Fourth, financial constraints limit expression profiling experiments to a small number of observations of the same gene under identical conditions, reducing the statistical power of the experiment, making it impossible for the experiment to identify important but subtle changes. Finally, it takes a great amount of effort to discuss the biological significance of each regulated gene, so scientists often limit their discussion to a subset. Newer microarray analysis techniques automate certain aspects of attaching biological significance to expression profiling results, but this remains a very difficult problem.
https://en.wikipedia.org/wiki?curid=4007073
1,039,073
612,812
Some scientists and philosophers of science were critical of Newton's definitions of absolute space and time. Ernst Mach (1883) argued that absolute time and space are essentially metaphysical concepts and thus scientifically meaningless, and suggested that only relative motion between material bodies is a useful concept in physics. Mach argued that even effects that according to Newton depend on accelerated motion with respect to absolute space, such as rotation, could be described purely with reference to material bodies, and that the inertial effects cited by Newton in support of absolute space might instead be related purely to acceleration with respect to the fixed stars. Carl Neumann (1870) introduced a "Body alpha", which represents some sort of rigid and fixed body for defining inertial motion. Based on the definition of Neumann, Heinrich Streintz (1883) argued that in a coordinate system where gyroscopes do not measure any signs of rotation inertial motion is related to a "Fundamental body" and a "Fundamental Coordinate System". Eventually, Ludwig Lange (1885) was the first to coin the expression inertial frame of reference and "inertial time scale" as operational replacements for absolute space and time; he defined "inertial frame" as ""a reference frame in which a mass point thrown from the same point in three different (non-co-planar) directions follows rectilinear paths each time it is thrown"". In 1902, Henri Poincaré published a collection of essays titled "Science and Hypothesis", which included: detailed philosophical discussions on the relativity of space, time, and on the conventionality of distant simultaneity; the conjecture that a violation of the relativity principle can never be detected; the possible non-existence of the aether, together with some arguments supporting the aether; and many remarks on non-Euclidean vs. Euclidean geometry.
https://en.wikipedia.org/wiki?curid=1790788
612,501
224,609
Howard Gardner's theory of multiple intelligences is based on studies not only of normal children and adults, but also of gifted individuals (including so-called "savants"), of persons who have suffered brain damage, of experts and virtuosos, and of individuals from diverse cultures. Gardner breaks intelligence down into at least a number of different components. In the first edition of his book "Frames of Mind" (1983), he described seven distinct types of intelligence—logical-mathematical, linguistic, spatial, musical, kinesthetic, interpersonal, and intrapersonal. In a second edition of this book, he added two more types of intelligence—naturalist and existential intelligences. He argues that psychometric (IQ) tests address only linguistic and logical plus some aspects of spatial intelligence. A major criticism of Gardner's theory is that it has never been tested, or subjected to peer review, by Gardner or anyone else, and indeed that it is unfalsifiable. Others (e.g. Locke, 2005) have suggested that recognizing many specific forms of intelligence (specific aptitude theory) implies a political—rather than scientific—agenda, intended to appreciate the uniqueness in all individuals, rather than recognizing potentially true and meaningful differences in individual capacities. Schmidt and Hunter (2004) suggest that the predictive validity of specific aptitudes over and above that of general mental ability, or "g", has not received empirical support. On the other hand, Jerome Bruner agreed with Gardner that the intelligences were "useful fictions", and went on to state that "his approach is so far beyond the data-crunching of mental testers that it deserves to be cheered."
https://en.wikipedia.org/wiki?curid=168191
224,495
1,902,111
Hagenau et al. (2007) provide a primer on physioeconomics. They review the literature on the use of physiological measures in economic research, with a focus on how these measures can be used to understand group decision making and negotiation. They conclude that physiological measures can be a valuable tool for understanding economic decisions, but that more research is needed to determine the predictive power of these measures. Van de Vliert and Tol (2014) found that countries with harsher climates tend to have harsher governance, except in cases where the country is cold, dry, and wealthy. They argue that this is because harsh climates promote feelings of anxiety and insecurity, which lead to stricter social norms and more authoritarian governance. Other research has examined the link between climate and culture. Van de Vliert (2016) argues that different cultures emerge in different climatic conditions due to the different ways that people adapt to their environment. He suggests that this can help explain why some cultures are more unequal than others. For example, cultures in colder climates tend to be more individualistic and competitive, while those in hotter climates are more collectivist and cooperative. This difference may be due to the fact that cooperation is more effective in hot climates where people are physically closer together, while competition is more effective in cold climates where people need to conserve energy. There is also a growing body of research on the link between physiology and economics. Adam et al. (2008) found that emotions play a significant role in electronic auctions, with participants bidding more aggressively when they were feeling happy or angry. They suggest that these results have implications for our understanding of economic decision-making more generally. They also found evidence that physiological factors influence economic behavior, showing that people are more likely to take risks when they are hungry or thirsty.
https://en.wikipedia.org/wiki?curid=28442132
1,901,021
691,884
This makes possible, for example, the use of a lithium metal anode in a practical device, without the intrinsic limitations of a liquid electrolyte thanks to the property of lithium dendrite suppression in the presence of a solid-state electrolyte membrane. The utilization of a high capacity anode and low reduction potential, like lithium with a specific capacity of 3860 mAh g and a reduction potential of -3.04 V vs SHE, in substitution of the traditional low capacity graphite, which exhibits a theoretical capacity of 372 mAh g in its fully lithiated state of LiC, is the first step in the realization of a lighter, thinner and cheaper rechargeable battery. Moreover, this allows the reach of gravimetric and volumetric energy densities, high enough to achieve 500 miles per single charge in an electric vehicle. Despite the promising advantages, there are still many limitations that are hindering the transition of SSEs from academia research to large-scale production, depending mainly on the poor ionic conductivity compared to that of liquid counterparts. However, many car OEMs (Toyota, BMW, Honda, Hyundai) expect to integrate these systems into viable devices and to commercialize solid-state battery-based electric vehicles by 2025.
https://en.wikipedia.org/wiki?curid=64345812
691,521
1,177,066
SWITCH is a power system model, focused on renewables integration. It can identify which generator and transmission projects to build in order to satisfy electricity demand at the lowest cost over a several-year period while also reducing emissions. SWITCH utilizes multi-stage stochastic linear optimization with the objective of minimizing the present value of the cost of power plants, transmission capacity, fuel usage, and an arbitrary per-tonne charge (to represent either a carbon tax or a certificate price), over the course of a multi-year investment period. It has two major sets of decision variables. First, at the start of each investment period, SWITCH selects how much generation capacity to build in each of several geographic load zones, how much power transfer capability to add between these zones, and whether to operate existing generation capacity during the investment period or to temporarily mothball it to avoid fixed operation and maintenance costs. Second, for a set of sample days within each investment period, SWITCH makes hourly decisions about how much power to generate from each dispatchable power plant, store at each pumped hydro facility, or transfer along each transmission interconnector. The system must also ensure enough generation and transmission capacity to provide a planning reserve margin of 15% above the load forecasts. For each sampled hour, SWITCH uses electricity demand and renewable power production based on actual measurements, so that the weather-driven correlations between these elements remain intact.
https://en.wikipedia.org/wiki?curid=38803848
1,176,443
993,292
In mid-1943, a new La-5 was captured by the Germans after making a forced landing at a German airfield. The aircraft was assessed by "Luftwaffe" test pilot Hans-Werner Lerche. Lerche noted that the La-5FN excelled at altitudes below 3,000 m (9,843 ft) but suffered from short range and flight time of only 40 minutes at cruise engine power. All of the engine controls (throttle, mixture, propeller pitch, cowl flaps, and supercharger gearbox) had separate levers which forced the pilot to make constant adjustments during combat or risk suboptimal performance. For example, rapid acceleration required moving no less than six levers. In contrast, contemporary German aircraft with the BMW 801 used the "Kommandogerät" engine computer system that automatically controlled all of these settings from a single throttle lever. Due to airflow limitations, the engine boost system ("Forsazh") could not be used above 2,000 m (6,562 ft). Stability in all axes was generally good. The authority of the ailerons was deemed exceptional but the rudder was insufficiently powerful at lower speeds. At speeds in excess of 600 km/h (370 mph), the forces on control surfaces became excessive. Horizontal turn time at 1,000 m (3,281 ft) and maximum engine power was 25 seconds.
https://en.wikipedia.org/wiki?curid=530494
992,775
1,045,052
After more fossil material was found, including bones, excavation of the bone-bearing layer commenced in April 1999, conducted by a local association of private fossil collectors. Although the quarry operator was cooperative, excavation was complicated by the near-vertical orientation of the layers that limited access, as well as by the ongoing quarrying. The sauropod material could not be excavated directly from the layer but had to be collected from lose blocks that resulting from blasting. The exact origin of the bone material was therefore unclear, but could later be traced to a single bed (bed 83). An excavation conducted between July 20–28 of 2000 rescued ca. of bone-bearing blocks containing vertebrate remains. Fossils were prepared and stored in the Dinosaur Park Münchehagen (DFMMh), a private dinosaur open-air museum located close to Hanover. Due to the very good preservation of the bones, consolidating agents had to be applied only occasionally, and preparation could be conducted comparatively quickly as bone would separate easily from the surrounding rock. Bones of simple shape could sometimes be prepared in less than an hour, while the preparation of a sacrum required a workload of three weeks. By January 2001, 200 single vertebrate bones had already been prepared. At this point, the highest bone density was found in a block measuring 70 x 70 cm, which contained ca. 20 bones. By January 2002, preparation of an even larger block had revealed a partial sauropod skull – the first to be discovered in Europe. Before complete removal of the bones from the block, a silicon cast was made of the block to document the precise three-dimensional position of the individual bones.
https://en.wikipedia.org/wiki?curid=5468113
1,044,508
1,004,304
The next World Championship took place in 2010 in the Czech Republic. Many people waited for another match between United States and Russia in playoffs. Both teams won all their group matches but then Russia suffered shocking defeat to Belarus in the quarterfinals (53–70). The defending champions, Australia also surprisingly lost quarterfinal match to hosts - Czech team (68–79). In the semifinals, Czech Republic beat Belarus in overtime (81–77) and reach final match for the first time after dissolution of Czechoslovakia. However, in the final match United States looked stronger and managed to return World title after victory with margin of 20 points (89–69). Spain won World Championship medals for first time in their history after beating Belarus in a bronze medal match (77–68). The next three edition were held without participation of Russian team who failed to qualify to 2014 and 2018 tournaments and was banned from participation in the 2022 World Cup due to the invasion of Ukraine. In 2014 US team repeated their success by beating Spain in the final match (77–64). The home team, Turkey managed to reach semifinals for first time in history but failed to win medals after losing to Australia in a bronze medal match (44–74). At the next 2018 World Cup in Spain, United States captured gold again after victory over Australia in a final match (73–56). The home team, Spain reached podium for third time in a row after victory over Belgium in a bronze medal match (67–60). The number of participants of the 2022 World Cup was reduced from 16 to 12 teams. United States won gold medals for fourth time in a row by beating China in a final match (83–61). Therefore, US team won eight of last ten World tournaments, captured their 11th World title and extended own winning streak at these competitions to 30 consecutive matches. The home team, Australia defeated Canada in a bronze medal match (95–65) and thus reached podium for third time in a row.
https://en.wikipedia.org/wiki?curid=5779563
1,003,786
101,092
The player starts out with a silent pseudo-protagonist in the form of an anthropomorphous biomechanical combat unit called 'Warframe' possessing supernatural agility and special abilities, a selection of basic weapons (primary, secondary and melee) and a space ship called 'Orbiter'. The player's primary goal from this point is to explore the Origin System. Later in the course of the game, the player unlocks the ability to gain direct control of the 'Operator', which is the true Tenno protagonist in physical form (and no longer silent). The Operator is able to physically manifest themselves in the environment by projecting out of the Warframe, and disappear by resuming control of it (a process called 'Transference'), and possesses abilities of their own. Subsequent to that, the Operator is able to Transference into a larger, purely mechanical combat unit called 'Necramech', which is the technological precursor to the Warframes. Players can engage in space-bound combat using an auxiliary combat platform called 'Archwing', mounted on a Warframe, which comes with a unique set of abilities. Necramechs and Archwings (in space combat) don't use Warframe weapons, but heavy ranged weapons called 'Archguns'. However, the player can make an Archgun wieldable even by Warframes. Late in 2019, an update named Empyrean was introduced to the game letting players pilot and manage a distinct space ship called 'Railjack', which is a combat vessel unlike the Orbiter. This was designed as a co-op experience with up to four people working together, doing different jobs to keep the ship operational while destroying enemy ships. A Railjack-focused update was released in 2021, which brought expanded content and a new skill tree aimed at making solo play more accessible.
https://en.wikipedia.org/wiki?curid=38333096
101,047
1,757,335
In 1938, development began for a new light tank for the Japanese Army. While the Type 95 Ha-Go had performed well against the National Revolutionary Army of the China in the Second Sino-Japanese War and successfully engaged United States M3 Stuart light tanks on the Bataan Peninsula in December 1941, it was quickly growing obsolete. Although its 37mm gun was adequate for most light armor designed and built in the 1930s, the Ha-Go, like the tanks of the US Army prior to 1941, was not designed to fight enemy tanks, but rather to support the infantry. The Type 95's light armor made it vulnerable to .50 caliber machine gun fire and attempts to address these shortcomings via the Type 98 Ke-Ni and Type 2 Ke-To were steps in the right direction, but were still insufficient. Therefore, a complete design review was held and a prototype for a new standard light tank was completed by 1942. At this point the project was shelved, as the Imperial Japanese Army General Staff had to concede to the Imperial Navy's needs of raw materials necessary for the production of warships and warplanes. Mass production was finally authorized in 1945, by which time it was too late. Production was impossible due to shortages of materials such as steel, and the bombing of Japan. Only a single prototype was completed by the Hino Jido Sha company by the end of World War II.
https://en.wikipedia.org/wiki?curid=7715513
1,756,344
472,199
BioWare produced "Neverwinter Nights" (2002) for Atari, the first CRPG to fuse the third-edition "Dungeons & Dragons" rules with a 3D display in which the user could vary the viewing angle and distance. New game content could be generated using the Aurora toolset supplied as part of the game release, and players could share their modules and play cooperatively with friends online. Based in part on experiences while playing "Ultima Online", one of the goals during development was to reproduce the feel of a live pen-and-paper RPG experience, complete with a human Dungeon Master. "Neverwinter Nights" ("NWN") was very successful commercially, and spawned three official expansion packs and a sequel developed by Obsidian Entertainment. BioWare later produced the acclaimed "", which married the d20 system with the "Star Wars" franchise; as well as the original "Jade Empire" (2005), "Mass Effect" (2007–2012) and "Dragon Age" (2009–2014) series, all which were released for multiple platforms. With the "Mass Effect" and the "Dragon Age" titles, Bioware also utilized a save import system where decisions in the earlier games impact the story in the later games.
https://en.wikipedia.org/wiki?curid=32408640
471,963
1,968,321
Non-profit work on water accessibility without government support is currently occurring, in Northern Peru, in the Talara region. EcoSwell identified a need for sustainable organizing and environmental and economic stability. Their bottom-up approach to community mobilization focuses on "the needs of the base of the pyramid". Ecoswell has chosen the town of Lobitos for its coastal location, its growing population, and its flow of tourism, as well as the threat to this town from climate change. EcoSwell has multiple projects focused on the long-term sustainability of this region's ecology, with a commitment to "no growth" or to a "steady-state economy". Ecoswell's projects are in line with the Peruvian government's commitment and recognized success in achieving the "sustainability sweet spot". One project uses solar-powered distillers to desalinate ocean water; Ecoswell is currently seeking support from the community and more funding to expand this project. Lobitos is located in a dry zone that does not have a lot of access to fresh water, so desalinization (drawing on the ocean nearby) is a smart alternative during drought periods.
https://en.wikipedia.org/wiki?curid=10611984
1,967,188
2,084,068
The expected German offensive (Operation Michael) opened at 04.30 on 21 March, and all the battery areas came under gas and HE shelling. Morning mist assisted the attackers and made visual signalling impossible, while telephone lines were cut by shellfire. However, in the absence of orders the batteries began firing on their pre-arranged targets. The Germans quickly overran XIX Corps' forward battalions (of 24th and 66th (2nd East Lancashire) Divisions), and by 08.00 were pushing troops down the valley north-east of Templeux. They outflanked the strong defences at the nearby quarries, which were evacuated, and they reached the village about 08.35. The three guns of 41st Siege Bty there were taken by surprise and the detachments came under rifle and machine gun fire. Major Fillingham evacuated his gunners and then went back to put the guns out of action and set fire to the cartridges while the Germans were only away. When the mist cleared about 11.30 the Germans could be seen streaming forward. 23rd Brigade was ordered to withdraw its guns to the prepared positions in the Brown Line; Fillingham got the two remaining guns of 41st Siege Bty's rear section away from in front of Roisel, even though the transport had not arrived and all the stores had to be abandoned. Major Fillingham was later awarded a Bar to his MC for his 'conspicuous gallantry and devotion to duty' that day.
https://en.wikipedia.org/wiki?curid=69464934
2,082,868
1,932,827
At the present day cyclostome bryozoans are exclusively marine and stenohaline, with most species living subtidally on the continental shelf. UK government-sponsored scientific reports in connection with renewable energy in 2014 uncovered the first recordings of Escharoides bishop and the non-native Fenestrulina delicia in British waters Relative to cheilostomes, they appear to be less numerous and diverse in low latitudes - temperate and arctic environments host almost all of the large species. Although some cyclostomes encrust fleshy algae, the majority colonize hard substrates. Encrusting species can be especially numerous in cryptic habitats, for example, the concave interiors of bivalve shells. Cyclostomes are comparatively poor competitors for living space - they are routinely overgrown by larger animals such as sponges and ascidians, and also lose the majority of competitive encounters for space with cheilostome bryozoans. Tentacle size and number tend to be smaller in species of cyclostomes than cheilostomes. As a result, cyclostomes create less powerful feeding currents. Colony size is small in many encrusting species, suggesting a "weedy", opportunistic lifestyle. These small encrusting colonies probably live for less than a year, whereas some of the larger encrusting and erect colonies are undoubtedly perennials. However, scant data exists on growth rates in cyclostomes.
https://en.wikipedia.org/wiki?curid=3907067
1,931,719
1,405,537
Bertozzi has developed numerous novel mathematical theories throughout her career. While a Dickson Instructor at Univ. of Chicago, she developed the mathematical theory of thin film equations, fourth order degenerate parabolic equations that are used to describe lubrication theory for coating flows. She has also worked with Jeffrey Brantingham and other colleagues to apply mathematics to the patterns of urban crime, research which was the cover feature in the March 2, 2010 issue of Proceedings of the National Academy of Sciences. Bertozzi also spoke about the mathematics of crime at the 2010 annual meeting of the American Association for the Advancement of Science. Since 2017, Bertozzi has been developing new mathematics related to microfluidic technologies as part of her Simons Math + X investigator program joint with UCLA's Department of Mechanical and Aerospace Engineering and the California NanoSystems Institute. That work includes the theory of transient growth for linear stability of driven contact lines and the theory of undercompressive shocks in driven films with nonconvex fluxes. In 2020, she applied these ideas to discover a new class of undercompressive shock solutions in the "tears of wine" problem.
https://en.wikipedia.org/wiki?curid=37498758
1,404,747
293,444
The "cavity" magnetron was a radical improvement introduced by John Randall and Harry Boot at the University of Birmingham, England in 1940. Their first working example produced hundreds of watts at 10 cm wavelength, an unprecedented achievement. Within weeks, engineers at GEC had improved this to well over a kilowatt, and within months 25 kilowatts, over 100 kW by 1941 and pushing towards a megawatt by 1943. The high power pulses were generated from a device the size of a small book and transmitted from an antenna only centimeters long, reducing the size of practical radar systems by orders of magnitude. New radars appeared for night-fighters, anti-submarine aircraft and even the smallest escort ships, and from that point on the Allies of World War II held a lead in radar that their counterparts in Germany and Japan were never able to close. By the end of the war, practically every Allied radar was based on a magnetron.
https://en.wikipedia.org/wiki?curid=20861
293,286
1,740,836
"P. hermaphrodita" is unsegmented, vermiform, bilateral symmetrical pseudocoelomate. The body dimensions and structure of "P. hermaphrodita" is comparable to "C. elegans"' with a body length 1.3 - 1.7mm long and an estimated circumference of 0.180mm. The primary structures are the Rhabditida-specific mouth, the pharynx, the intestine, the reproductive system (uterus, spermatheca, gonads) and the cuticle. Like all nematodes, it has four muscle bands that span the length of the body and has no devoted respiratory or circulatory system. "P. hermaphrodita" has four larval stages before becoming a fully reproductive hermaphroditic adult female. Males do exist in this species, but are very rare with Maupas only able to find 21 males among 15,000 individuals (0.14% of the population). Third-stage dauer larvae are produced in unfavourable conditions such as low food levels, high population density or high temperatures. Dauer larvae have constricted pharynx, double the thickness of a normal cuticle and increase of lipid droplets in their cytoplasm. However, the most important aspect of the dauer stage is its ability to serve as the infective stage that seeks out new hosts, once the previous bacterial food source has been depleted. Dauers do not require a food source and can survive up to eight times longer than the original life span of a non-dauer nematode. "P. hermaphrodita" is morphologically identical to two other "Phasmarhabditis" species "P. neopapillosa" and "P. tawfiki". However, "P. neopapillosa" is a gonochoristic species with an equal number of males and females.
https://en.wikipedia.org/wiki?curid=29906722
1,739,855
1,161,556
Held since 1973, this event is for rowers 27 years of age or over. Men and women compete in age categories ranging from "A" (27 to 35) to "K" (85 and older). The largest annual international regatta, in 2013 it attracted approximately 3500 competitors who competed in 440 races over four days. There are also events for mixed crews – where half the crew is men and half women (excluding cox). The 2010 regatta took place in St. Catharines, Ontario, Canada, 2011 in Poznan, Poland, 2012 in Duisburg, Germany, 2013 in Varese, Italy, 2014 in Ballarat, Australia, 2015 in Hazewinkel, Belgium, 2016 in Copenhagen, Denmark, 2017 in Bled, Slovenia, 2018 in Sarasota, Florida, USA, and 2019 in Lake Valence, Hungary. Due to the COVID-19 pandemic, the 2020 regatta was a virtual competition on indoor rowers. The 2021 regatta will be in Linz-Ottensheim, Austria, 2022 in Libourne, France, 2023 in Pretoria, South Africa, and 2024 in Brandenburg, Germany.
https://en.wikipedia.org/wiki?curid=400154
1,160,940