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Also in 1845 he became the first President of Queen's College, Cork (now University College Cork). He did not spend a lot of time in Cork as he had work in Dublin, and his wife lived there. The science building on the campus of this college (now University College Cork) is named in honour of Kane. He was knighted in 1846. In 1873, Kane took up the post of National Commissioner for Education. He was elected president of the Royal Irish Academy in 1877, holding the role until 1882. In 1880 he was appointed the first chancellor of the newly created Royal University of Ireland. After a motion to admit women to the University, put forward by Prof. Samuel Haughton at Academic Council in Trinity College Dublin, 10 March 1880, Kane was appointed to a committee of 10 men to look into the matter. He was opposed to the admission of women, and nothing was reported from the committee in the Council minutes for the next 10 years (Parkes, 2004).
https://en.wikipedia.org/wiki?curid=2003324
2,058,129
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Calcium batteries are considered a next generation battery or post-Li-ion battery energy storage system, namely one of the many candidates that may potentially replace lithium-ion battery technology. It is also a multivalent battery. Key advantages are lower cost, earth abundance (41,500 ppm), higher energy density, by a combination of high capacity and a high cell voltage, and potentially higher power output. Calcium is the 5th most abundant mineral in the Earth's crust, and the most abundant alkaline earth metal, and the third most abundant metal after aluminum (Al) and iron (Fe). The United States is the largest producer (by annual production) of calcium sources (primarily lime), promising domestic supply and manufacture. Other major producers include Russia and China.
https://en.wikipedia.org/wiki?curid=63175392
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While most people celebrated the accomplishment, disenfranchised Americans saw it as a symbol of the divide in America, evidenced by protesters led by Ralph Abernathy outside of Kennedy Space Center the day before Apollo 11 launched. NASA Administrator Thomas Paine met with Abernathy at the occasion, both hoping that the space program can spur progress also in other regards, such as poverty in the US. Paine was then asked, and agreed, to host protesters as spectators at the launch, and Abernathy, awestruck by the spectacle, prayed for the astronauts. Racial and financial inequalities frustrated citizens who wondered why money spent on the Apollo program was not spent taking care of humans on Earth. A poem by Gil Scott-Heron called "Whitey on the Moon" (1970) illustrated the racial inequality in the United States that was highlighted by the Space Race. The poem starts with:
https://en.wikipedia.org/wiki?curid=662
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In the U.S., writing received greater attention after a large number of students' enrollment in the US universities in the 1960s. This meant that not only teaching reading and speaking skills were important as they were needed for working during the industrialization, but teaching a language required also writing as international students could function in American universities. During this period, postsecondary institutions could no longer ignore the difficulties L2 writers faced as the number of international students increased 4 times more in 1950 compared to 1940 and all freshman students had to take first year composition courses. Specialists had to design courses for L2 writers that were considered as remedial courses in some universities while other institutions credited these courses. To solve the challenges L2 writers encounter, both "composition teachers" and "ESL teachers" attended the meeting organized by Conference on College Composition and Communication (CCCC) established in 1949 as a forum for specialists in the field of composition. Specialists and educators discussed the materials that needed to be used for teaching L2 writing instruction, and ESL specialists suggested using materials designed by Michigan English Language Institute (ELI). Michigan ELI was the first language teaching institute founded to teach English to Spanish language speakers, and the institute also provided courses for teaching ESL. Second language writing issues were considered both by composition and ESL teachers at the conference.
https://en.wikipedia.org/wiki?curid=2033659
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Several shows during the Summer leg had to be rescheduled or canceled after Maida contracted a throat infection. A cancer scare which turned out to be harmless caused bassist Duncan Coutts to miss six weeks of touring following the shoot for the "Life" video in February. Rob Higgins of the band Change of Heart filled in for him while he recovered from surgery. Coutts would also miss several shows in June after breaking his wrist in a biking accident. The band wrapped up the tour with a performance at Music Without Borders at Toronto's Air Canada Centre on October 21, 2001. This would be their last live performance with Mike Turner. Several songs were recorded live by the band in Syracuse, New York with hopes of releasing a live album with producer Bob Rock and then to continue touring for the album. The live tracks were instead spread across various promos and singles and the band decided to record a full-length album, "Gravity", with Rock.
https://en.wikipedia.org/wiki?curid=1941326
1,072,615
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Many biographies published before Rispens' work, state that Debye moved to the US because he refused to accept German citizenship forced on to him by the Nazis. He planned his departure from Germany during a visit with his mother in Maastricht in late 1939, boarded a ship in Genoa in January 1940 and arrived in New York in early February 1940. He immediately sought a permanent position in the US and accepted such an offer from Cornell in June 1940. That month, he crossed the US border into Canada and returned within days on an immigration visa. He was able to get his wife out of Germany and to the US by December 1940. Although his son already was in the US before he departed, Peter Debye's 19-year-old daughter and his sister-in-law did not leave. They lived in his official residence in Berlin and were supported by Debye's official Berlin wages (he carefully maintained an official leave of absence for this purpose).
https://en.wikipedia.org/wiki?curid=37067
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The University was founded by Royal Charter from King James VI in 1582 and opened in 1583, however the library pre-dated this by three years. The initial collection was a bequest of 276 theological books from Clement Littill, an advocate who left his collection to the town in 1580. Until 1708, the teaching staff consisted of four regents and the Principal, the former taking each class through a year's part of the whole arts curriculum of logic, metaphysics, ethics and physics, which included the elements of mathematics and astronomy. Until the middle of the 17th century, by which time the library must have exceeded the 2,400-odd volumes listed in Robert Lumsden's shelf catalogue of 1637, the teaching tended to be commentaries on Aristotle.
https://en.wikipedia.org/wiki?curid=24201555
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The typographer consisted of a wooden box with a swinging lever on one end for impressing. The typeface letters were mounted on a short sector attached on the underside of the lever. Pressing down imprinted the letter selected onto the paper. The paper was on a large continuous roll and the printed part was torn off giving the typed document or letter wanted. One could print both upper and lower case letters. The first writing machine Burt built did not live up to his expectation, so he built an improved version six months later that wasn't much faster. The improvements were mostly in looks and appearance for marketing the machine to investors. While Burt's typographer generated a lot of interest and did a very good job of typing clear and neat letters. It did not become a commercial success as his typographer was "born out of season". Burt's typing machine was before a time of much need for such a machine. No market was found for the device or his patent during his lifetime.
https://en.wikipedia.org/wiki?curid=2399453
1,283,292
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The legacy of anthropologists and archaeologists "behaving badly" with respect to native people has affected 21st century relations. For instance, indigenous peoples pushed for passage by the US Congress of the Native American Graves Protection and Repatriation Act (NAGPRA), due to their strong dissatisfaction with the conduct of archaeologists. In their pursuit of science, they overrode strong cultural traditions associated with grave sites and artifacts. Similarly, in Canada the legislature passed the Heritage Conservation Act (1994). Provincial governments have recognised that local First Nations had an interest in being consulted in the archaeological permit application process. In many cases, consultation has arranged for additional roles for them and sometimes become vehicles for community and economic development.
https://en.wikipedia.org/wiki?curid=21924068
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Gardasil is a three-dose (injection) vaccine. , there were more than 57 million doses distributed in the United States, though it is unknown how many were administered. There have been 22,000 Vaccine Adverse Event Reporting System (VAERS) reports following the vaccination. 92% were reports of events considered to be non-serious (e.g., fainting, pain and swelling at the injection site (arm), headache, nausea and fever), and the rest were considered to be serious (death, permanent disability, life-threatening illness and hospitalization). However, VAERS reports include any reported effects whether coincidental or causal. In response to concerns regarding the rates of adverse events associated with the vaccine, the CDC stated: "When evaluating data from VAERS, it is important to note that for any reported event, no cause-and-effect relationship has been established. VAERS receives reports on all potential associations between vaccines and adverse events."
https://en.wikipedia.org/wiki?curid=3304705
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Numbers uses a hybrid approach to the creation of formulas, supporting the use of named data like Improv, but implementing them in-sheet like Excel. In basic operation, Numbers can be used just like Excel; data can be typed anywhere and formulas can be created by referring to the data by its cell. However, if the user types a header into the table, something one normally does as a matter of course, Numbers uses this to automatically construct a named range for the cells on that row or column. For instance, if the user types "month" into A1 and then types the names "January", "February", etc. into the cells below it, Numbers constructs a named range for the cells A2 through A13 and gives it the name "month". The same is true when the user types in the figures for "sales" and "income". The user can then write the averaging formula in a category-like text format, codice_4. The formula will find the appropriate data and calculate the results independent of the row. Like Improv, this formula does not refer to the physical location of the data in the sheet, so the sheet can be dramatically modified without causing the formula to fail.
https://en.wikipedia.org/wiki?curid=12665211
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GNSS differs from traditional navigation systems because the satellites and areas of degraded coverage are in constant motion. Therefore, if a satellite fails or is taken out of service for maintenance, it is not immediately clear which areas of the airspace will be affected, if any. The location and duration of these outages can be predicted with the aid of computer analysis and reported to pilots during the pre-flight planning process. This prediction process is, however, not fully representative of all RAIM implementations in the different models of receivers. Prediction tools are usually conservative and thus predict lower availability than that actually encountered in flight to provide protection for the lowest end receiver models.
https://en.wikipedia.org/wiki?curid=793435
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After the Gulf War in 1991, in which Israeli towns were attacked by SCUD missiles based in Iraq, the Israeli government decided a long range strike aircraft was needed, issuing a Request for Information (RFI). In response, Lockheed Martin offered a version of the F-16 Fighting Falcon, while McDonnell Douglas offered both the F/A-18 Hornet and the F-15E. On 27 January 1994, the Israeli government announced their intention to buy 21 modified F-15Es, designated "F-15I". On 12 May 1994, the US Government authorized the purchase of up to 25 F-15Is by Israel. In November 1995, Israel ordered four extra F-15Is; 25 were built from 1996 to 1998. Some of the air-to-air missiles aircraft can carry: the AIM-9L, Rafael Python 4 and the Rafael Python 5 infrared-homing missiles; and the AIM-7 Sparrow and the AIM-120 AMRAAM radar-guided missiles. In 1999, Israel announced its intention to procure more fighters and that a possible contender was the F-15I. However, the contract went to the F-16I.
https://en.wikipedia.org/wiki?curid=495724
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The operational-level strategist possesses numerous tools to frame and guide their thinking, but chief among these are mission analysis and end state. Mission analysis answers the question "What is to be accomplished?" Through mission analysis, the operational-level planner fuses political aims and military objectives. In so doing, the planner determines what application of military force will create military power to achieve the political purpose. Subordinate processes here include defining objectives and centers of gravity, but excessive dependence on analytical mechanisms can create false security. The final test rewards success, not the quality of the argument. Conversely, the planner cannot hope to "feel" a way to victory—complexity demands an integration of thought and effort.
https://en.wikipedia.org/wiki?curid=1436399
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Mayr encouraged his Linnaean Society seminar participants to take up a specific research project of their own. Under Mayr's influence one of them, Joseph Hickey, went on to write "A Guide to Birdwatching" (1943). Hickey remembered later, "Mayr was our age and invited on all our field trips. The heckling of this German foreigner was tremendous, but he gave tit for tat, and any modern picture of Dr E. Mayr as a very formal person does not square with my memory of the 1930s. He held his own." A group of eight young birdwatchers from The Bronx later became the Bronx County Bird Club, led by Ludlow Griscom. "Everyone should have a problem" was the way one Bronx County Bird Club member recalled Mayr's refrain. Mayr said of his own involvement with the local birdwatchers: "In those early years in New York when I was a stranger in a big city, it was the companionship and later friendship which I was offered in the Linnean Society that was the most important thing in my life."
https://en.wikipedia.org/wiki?curid=9238
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Diplodocoidea is defined as all neosauropods more closely related to "Diplodocus longus" than "Saltasaurus loricatus". The group is named after "Diplodocus", its best known member. Other prominent dinosaurs contained in this clade include "Apatosaurus", "Supersaurus", and "Brontosaurus". Diplodocoids are distinguished by a unique head shape, which displays certain highly derived features when compared to other sauropods. The teeth are located entirely anterior to the antorbital fenestra and the snout is especially broad. In some rebbachisaurids, this is taken to such an extreme that the teeth are packed into a row along the transverse portion of the jaw. Several unique features are also noted in the tails of certain diplodocoids. Among the diplodocids, there was a marked increase in the number of caudal vertebrae. Most sauropods have between forty and fifty caudal vertebrae, but in diplodocids this number jumps to eighty or more. In addition, the most distal vertebrae develop a biconvex shape and together form a long, bony rod at the end of the tail, often referred to as a “whiplash tail.” Increased caudal count and a whiplash tail may be features shared by all members of the Diplodocoid group, but, due to a scarcity of evidence, this has yet to be proven.
https://en.wikipedia.org/wiki?curid=9714882
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Blood transfusion is indicated if PCV drops below 12%. The mare's blood may be used for transfusion if the red blood cells are washed multiple times to remove the serum component containing antibodies. If the mare can not be used, an alternative donor that is Aa and Qa negative may be used. This donor profile is most commonly seen in Quarter Horses, Morgans, and Standardbreds and is less likely in Thoroughbreds and Arabians, but ideally the donor should be blood typed prior to use rather than using breed as the sole method of identification. In mule foals, female donors that have been previously bred to a jack should not be used. Transfusion usually consists of 2-4 L of blood, or 1-2 L of packed cells, over the course of 2–4 hours. Blood transfusion is not without risks: these cells stress the mononuclear phagocytic system, increasing the foal's risk of infection, and also may lead to future transfusion reactions, so transfusion should only occur if required to save the animal's life. In the rare case where a suitable donor is not available or hemoglobin levels drop below 5 mg/dl, polymerized bovine hemoglobin may be given. PCV declines 4–7 days after initial transfusion. Dexamethasone is also sometimes used, but can affect blood glucose regulation of the patient.
https://en.wikipedia.org/wiki?curid=11331670
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Sega's "Sakura Wars" for the Saturn combined tactical RPG combat with dating sim and visual novel elements, introducing a real-time branching choice system where, during an event or conversation, the player must choose an action or dialogue choice within a time limit, or not to respond at all within that time; the player's choice, or lack thereof, affects the player character's relationship with other characters and in turn the characters' performance in battle, the direction of the storyline, and the ending. Later games in the series added several variations, including an action gauge that can be raised up or down depending on the situation, and a gauge that the player can manipulate using the analog stick depending on the situation. The success of "Sakura Wars" led to a wave of games that combine the RPG and dating sim genres, including "Thousand Arms" in 1998, "" in 2002, and "Luminous Arc" in 2007.
https://en.wikipedia.org/wiki?curid=32408675
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Around this same timeframe, the Air Ministry introduced a program of experimental aircraft to examine the effects of swept wings, as well as the delta wing configuration. Furthermore, the Royal Air Force (RAF) identified a pair of proposed fighter aircraft equipped with swept wings from Hawker Aircraft and Supermarine, the Hawker Hunter and Supermarine Swift respectively, and successfully pressed for orders to be placed 'off the drawing board' in 1950. On 7 September 1953, the sole Hunter Mk 3 (the modified first prototype, "WB 188") flown by Neville Duke broke the world air speed record for jet-powered aircraft, attaining a speed of 727.63 mph (1,171.01 km/h) over Littlehampton, West Sussex. This world record stood for less than three weeks before being broken on 25 September 1953 by the Hunter's early rival, the Supermarine Swift, being flown by Michael Lithgow.
https://en.wikipedia.org/wiki?curid=246851
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In the absence of liver disease, high levels of total bilirubin confers various health benefits. Studies have also revealed that levels of serum bilirubin (SBR) are inversely related to risk of certain heart diseases. While the poor solubility and potential toxicity of bilirubin limit its potential medicinal applications, current research is being done on whether bilirubin encapsulated silk fibrin nanoparticles can alleviate symptoms of disorders such as acute pancreatitis. In addition to this, there has been recent discoveries linking bilirubin and its ε-polylysine-bilirubin conjugate (PLL-BR), to more efficient insulin medication. It seems that bilirubin exhibits protective properties during the islet transplantation process when drugs are delivered throughout the bloodstream.
https://en.wikipedia.org/wiki?curid=68344
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Socrates was born in 470 or 469 BC to Sophroniscus and Phaenarete, a stoneworker and a midwife, respectively, in the Athenian deme of Alopece; therefore, he was an Athenian citizen, having been born to relatively affluent Athenians. He lived close to his father's relatives and inherited, as was customary, part of his father's estate, securing a life reasonably free of financial concerns. His education followed the laws and customs of Athens. He learned the basic skills of reading and writing and, like most wealthy Athenians, received extra lessons in various other fields such as gymnastics, poetry and music. He was married twice (which came first is not clear): his marriage to Xanthippe took place when Socrates was in his fifties, and another marriage was with a daughter of Aristides, an Athenian statesman. He had three sons with Xanthippe. Socrates fulfilled his military service during the Peloponnesian War and distinguished himself in three campaigns, according to Plato.
https://en.wikipedia.org/wiki?curid=25664190
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While reports by owners of fitting names are of interest, some scientists, including Michalos and Smeets, have questioned their value in deciding whether nominative determinism is a real effect. Instead, they argue that the claim that a name affects life decisions is an extraordinary one that requires extraordinary evidence. To select only those cases that seem to give evidence for nominative determinism is to ignore those that do not. Analysis of large numbers of names is therefore needed. In 2002 Pelham, Mirenberg, and Jones analysed various databases containing first names, surnames, occupations, cities and states. In one study they concluded that people named Dennis gravitate towards dentistry. They did this by retrieving the number of dentists called Dennis (482) from a database of US dentists. They then used the 1990 Census to find out which male first name was the next most popular after Dennis: Walter. The likelihood of a US male being called Dennis was 0.415% and the likelihood of a US male being called Walter was 0.416%. The researchers then retrieved the number of dentists called Walter (257). Comparing the relative frequencies of Dennis and Walter led them to their conclusion that the name Dennis is over-represented in dentistry. However, in 2011, Uri Simonsohn published a paper in which he criticized Pelham "et al." for not considering confounding factors and reported on how the popularity of Dennis and Walter as baby names has varied over the decades. Given Walter was a relatively old-fashioned name it was far more likely for Pelham "et al." to find people named Dennis to have any job, not just that of dentist, and people named Walter to be retired. Simonsohn did indeed find a disproportionally high number of Dennis lawyers compared to Walter lawyers.
https://en.wikipedia.org/wiki?curid=2326978
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Acute pancreatitis occurs when there is abnormal activation of digestive enzymes within the pancreas. This occurs through inappropriate activation of inactive enzyme precursors called zymogens (or proenzymes) inside the pancreas, most notably trypsinogen. Normally, trypsinogen is converted to its active form (trypsin) in the first part of the small intestine (duodenum), where the enzyme assists in the digestion of proteins. During an episode of acute pancreatitis, trypsinogen comes into contact with lysosomal enzymes (specifically cathepsin), which activate trypsinogen to trypsin. The active form trypsin then leads to further activation of other molecules of trypsinogen. The activation of these digestive enzymes lead to inflammation, edema, vascular injury, and even cellular death. The death of pancreatic cells occurs via two main mechanisms: necrosis, which is less organized and more damaging, or apoptosis, which is more controlled. The balance between these two mechanisms of cellular death is mediated by caspases which regulate apoptosis and have important anti-necrosis functions during pancreatitis: preventing trypsinogen activation, preventing ATP depletion through inhibiting polyADP-ribose polymerase, and by inhibiting the inhibitors of apoptosis (IAPs). If, however, the caspases are depleted due to either chronic ethanol exposure or through a severe insult then necrosis can predominate.
https://en.wikipedia.org/wiki?curid=1035086
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King's was divided into a senior department and a junior department, also known as King's College School, which was originally situated in the basement of the Strand Campus. The Junior department started with 85 pupils and only three teachers, but quickly grew to 500 by 1841, outgrowing its facilities and leading it to relocate to Wimbledon in 1897 where it remains today, though it is no longer associated with King's College London. Within the Senior department teaching was divided into three courses. A general course comprised divinity, classical languages, mathematics, English literature and history. Secondly, there was the medical course. Thirdly, miscellaneous subjects, such as law, political economy and modern languages, which were not related to any systematic course of study at the time and depended for their continuance on the supply of occasional students. In 1833 the general course was reorganised leading to the award of the Associate of King's College (AKC), the first qualification issued by King's. The course, which concerns questions of ethics and theology, is still awarded today to students and staff who take an optional three-year course alongside their studies.
https://en.wikipedia.org/wiki?curid=49301271
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In Sweden, Lake Mälaren was formerly an arm of the Baltic Sea, but uplift eventually cut it off and led to its becoming a freshwater lake in about the 12th century, at the time when Stockholm was founded at its outlet. Marine seashells found in Lake Ontario sediments imply a similar event in prehistoric times. Other pronounced effects can be seen on the island of Öland, Sweden, which has little topographic relief due to the presence of the very level Stora Alvaret. The rising land has caused the Iron Age settlement area to recede from the Baltic Sea, making the present day villages on the west coast set back unexpectedly far from the shore. These effects are quite dramatic at the village of Alby, for example, where the Iron Age inhabitants were known to subsist on substantial coastal fishing.
https://en.wikipedia.org/wiki?curid=598434
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USS "Indiana" (SSN-789) is a nuclear powered United States Navy attack submarine, named for the State of Indiana. She is the sixteenth of her class and sixth of the significantly redesigned Block III, including a revised bow and VLS technology from the of guided missile submarines. "Indiana" was constructed by Huntington Ingalls Industries in partnership with the Electric Boat division of General Dynamics in Newport News, Virginia, with the initial contract awarded on 22 December 2008. Her keel was laid on 16 May 2015 and she was launched on 9 June 2017. The boat was christened on 29 April 2017 and sponsored by Diane Donald, wife of Admiral Kirkland H. Donald, USN (ret). She was commissioned on 29 September 2018 at Port Canaveral, Florida.
https://en.wikipedia.org/wiki?curid=21216987
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The setbacks of previous years were compensated by the prosperity and happiness of 1825. Publication had been moving more rapidly, the stress of poverty was for a time lightened, and in the summer he had a pleasant holiday in Upper Austria where he was welcomed with enthusiasm. It was during this tour that he produced the seven-song cycle "Fräulein am See", based on Walter Scott's "The Lady of the Lake", and including "Ellens Gesang III" ("Hymn to the Virgin") (D. 839, Op. 52, No. 6); the lyrics of Adam Storck's German translation of the Scott poem are now frequently replaced by the full text of the traditional Roman Catholic prayer Hail Mary ("Ave Maria" in Latin), but for which the Schubert melody is not an original setting. The original only opens with the greeting "Ave Maria", which also recurs only in the refrain. In 1825, Schubert also wrote the Piano Sonata in A minor (D 845, first published as op. 42), and began the Symphony in C major ("Great C major", D. 944), which was completed the following year.
https://en.wikipedia.org/wiki?curid=44888
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Regenerative farming or 'regenerative agriculture' calls for the creation of demand on agricultural systems to produce food in a way that is beneficial to the production and the ecology of the environment. It uses the science of systems ecology, and the design and application through permaculture. As understanding of its benefits to human biology and ecological systems that sustain us is increased as has the demand for organic food. Organic food grown using regenerative and permaculture design increases the biodiversity and is used to develop business models that regenerate communities. Whereas some foods are organic some are not strictly regenerative because it is not clearly seeking to maximize biodiversity and the resilience of the environment and the workforce. Regenerative agriculture grows organic produce through ethical supply chains, zero waste policies, fair wages, staff development and wellbeing, and in some cases cooperative and social enterprise models. It seeks to benefit the staff along the supply chain, customers, and ecosystems with the outcome of human and ecological restoration and regeneration.
https://en.wikipedia.org/wiki?curid=14967273
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The effect of maternal diet in species other than humans is also relevant. Many of the long term effects of global climate change are unknown. Knowledge of epigenetic mechanisms can help scientists better predict the impacts of changing community structures on species which are ecologically, economically, and/or culturally important around the world. Since many ecosystems will see changes in species structures, the nutrient availability will also be altered, ultimately affecting the available food choices for reproducing females. Maternal dietary effects may also be used to improve agricultural and aquaculture practices. Breeders may be able to utilize scientific data to create more sustainable practices, saving money for themselves, as well as the consumers.
https://en.wikipedia.org/wiki?curid=343457
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Pathologists' assistants have been employed in pathology labs for over 40 years. Formal training programs slowly appeared (there were four nationwide in the late 1990s). NAACLS began accrediting PathA programs in the late 1990s, and then programs slowly continued their transitions from bachelor's to master's programs as their number increased. Prior to ASCP certification, which came about in 2005, the AAPA had a fellowship status that program trained pathologists' assistants or on-the-job trained (OJT) pathologists' assistants (who could do specific coursework and three years of active employment) could join only based on passing a rigorous exam that parallels the current ASCP certification exam. The OJT route was eliminated at the end of 2007. The professional association uniting PAs is the American Association of Pathologists' Assistants. Part of their duties as an association is to provide continuing medical education credits (CME) in order to keep members current on advances and procedures in the field that must be completed every three years in order to maintain ASCP certification.
https://en.wikipedia.org/wiki?curid=35540901
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Although externally much like the later "fleet submarines," internally the "Cachalot"s were quite different. Due to pressure from the Submarine Officers Conference, they featured full double hulls adapted from the "Kaiserliche Marine"<nowiki>'</nowiki>s "U-135", direct-drive diesel-electric propulsion systems, a separate crew's mess (reinstated thanks to EB's rearrangement of the internal layout; Portsmouth would follow soon after), and considerable space around the conning tower within the large bridge fairwater (which was drastically cut down in World War II when the 3-inch (76 mm) deck gun was relocated forward of the bridge). The 3-inch gun was selected because it was felt at the time that a larger gun would encourage submarine captains to fight on the surface against superior anti-submarine ships; this remained the standard submarine deck gun until early in World War II, when war experience showed that a larger gun was needed.
https://en.wikipedia.org/wiki?curid=1580477
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Extreme programming encourages starting with the simplest solution. Extra functionality can then be added later. The difference between this approach and more conventional system development methods is the focus on designing and coding for the needs of today instead of those of tomorrow, next week, or next month. This is sometimes summed up as the "You aren't gonna need it" (YAGNI) approach. Proponents of XP acknowledge the disadvantage that this can sometimes entail more effort tomorrow to change the system; their claim is that this is more than compensated for by the advantage of not investing in possible future requirements that might change before they become relevant. Coding and designing for uncertain future requirements implies the risk of spending resources on something that might not be needed, while perhaps delaying crucial features. Related to the "communication" value, simplicity in design and coding should improve the quality of communication. A simple design with very simple code could be easily understood by most programmers in the team.
https://en.wikipedia.org/wiki?curid=38634705
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When Josephus Daniels organized a Naval Consulting Board during World War I, Whitney was recruited to be on it. Led by Thomas A. Edison, the purpose of the board was to field ideas and see which ones were viable. Whitney was appointed chairman of the chemistry and physics divisions and was soon put in charge of research of all nitrate production at Muscle Shoals on the Tennessee River. Using his connections at G.E. and Du Pont, he got an experimental submarine detection station built in Nahant, Massachusetts. While Whitney was in charge of the research, Irving Langmuir, who was also recruited, led the Nahant station, and Coolidge experimented with rubber tubing there. During this time, Whitney recruited Albert Hull from Worcester Polytechnic Institute to work with him at G.E. and on this project at Nahant. Eventually Coolidge developed his C-tube, a rubber tube with a piece of metal attached, that could detect submarines up to two miles away. Dr. Hull and colleagues eventually improved on this design to make the K-tube that could detect submarines up to ten miles away.
https://en.wikipedia.org/wiki?curid=6046838
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The event held in Kyoto was held in commemoration of "Respect for the Aged Day (held every September 15), with official timing and a field of younger competitors in their eighties, Miyazaki completed the race in 42.22, slower than the 34.50 recorded by Kowalski. Miyazaki only took up the sport in his nineties. "I'm still a beginner, you know. I'll have to train harder. Training was going splendidly, so I had set myself a target of 35 seconds. I can still go faster." Following his race he posed in the Lightning Bolt stance, made famous by Usain Bolt. "I will say this: I'm proud of my health. The doctors gave me a medical examination a couple of days ago and I'm fit as a fiddle. My brain might not be the sharpest but physically I'm tip-top. I've never had any health problems. The doctors are amazed by me. I can definitely keep on running for another two or three years. It's all about willpower. You have to keep going".
https://en.wikipedia.org/wiki?curid=47926481
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As a member of the Confessing Church, Schlink supported the Barmen Declaration. He later interpreted this confession favorably in light of several key teachings in the Book of Concord, especially the distinction between law and gospel. Because of pressure from the Gestapo, which he and his superiors received as a result of his public criticism of the German Christians ("Deutsche Christen"), Schlink was removed from his teaching position at Giessen. Between 1935 and 1939 he taught at the seminary in Bethel, near Bielefeld (see also Bethel Foundation). After the Gestapo closed that seminary in 1939 and restricted Schlink's speaking and public movement, Schlink began serving as a pastor to several "confessing" congregations in Hesse and Westphalia. These included the Marienkirche and St. Reinoldikirche in Dortmund and eventually the Neustädter Marienkirche in Bielefeld. During 1943 and 1944, he also traveled monthly to Strasbourg for two-week periods in which he taught practical theology to seminarians there. In 1945 he became the director of the preachers' seminary in Soest for the Evangelical Church of Westphalia. After only a year there, he was called to become a professor of dogmatic and ecumenical theology at Heidelberg University. He would remain a member of this faculty until his retirement in 1971.
https://en.wikipedia.org/wiki?curid=7037306
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The earliest recorded beginnings of geometry can be traced to early peoples, such as the ancient Indus Valley (see Harappan mathematics) and ancient Babylonia (see Babylonian mathematics) from around 3000 BC. Early geometry was a collection of empirically discovered principles concerning lengths, angles, areas, and volumes, which were developed to meet some practical need in surveying, construction, astronomy, and various crafts. Among these were some surprisingly sophisticated principles, and a modern mathematician might be hard put to derive some of them without the use of calculus and algebra. For example, both the Egyptians and the Babylonians were aware of versions of the Pythagorean theorem about 1500 years before Pythagoras and the Indian Sulba Sutras around 800 BC contained the first statements of the theorem; the Egyptians had a correct formula for the volume of a frustum of a square pyramid.
https://en.wikipedia.org/wiki?curid=11953
1,002,386
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Kepler has been assigned an observatory code in order to report its astrometric observations of small Solar System bodies to the Minor Planet Center. In 2013 the alternative "NEOKepler" mission was proposed, a search for near-Earth objects, in particular potentially hazardous asteroids (PHAs). Its unique orbit and larger field of view than existing survey telescopes allow it to look for objects inside Earth's orbit. It was predicted a 12-month survey could make a significant contribution to the hunt for PHAs as well as potentially locating targets for NASA's Asteroid Redirect Mission. Kepler's first discovery in the Solar System, however, was , a 200-kilometer cold classical Kuiper belt object located beyond the orbit of Neptune.
https://en.wikipedia.org/wiki?curid=849815
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The Roman physician Galen also argued for the importance of the brain, and theorized in some depth about how it might work. Galen traced out the anatomical relationships among brain, nerves, and muscles, demonstrating that all muscles in the body are connected to the brain through a branching network of nerves. He postulated that nerves activate muscles mechanically by carrying a mysterious substance he called "pneumata psychikon", usually translated as "animal spirits". Galen's ideas were widely known during the Middle Ages, but not much further progress came until the Renaissance, when detailed anatomical study resumed, combined with the theoretical speculations of René Descartes and those who followed him. Descartes, like Galen, thought of the nervous system in hydraulic terms. He believed that the highest cognitive functions are carried out by a non-physical "res cogitans", but that the majority of behaviors of humans, and all behaviors of animals, could be explained mechanistically.
https://en.wikipedia.org/wiki?curid=3717
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Christiansen uses Citizen Science and the Zooniverse to help in her quest for exoplanets using the Kepler Space Telescope K2 dataset. She worked with Professor Ian Crossfield at MIT to ensure the K2 data was made public, and in January 2018 announced the discovery of 5 massive exoplanets orbiting the sun-like star K2-138. The exoplanets make up the longest chain of synchronised exoplanets ever discovered, orbiting in near-perfect resonance to their star. In an interview with the BBC, Christiansen spoke about the importance of crowdsourcing research projects "people anywhere can log on and learn what real signals from exoplanets look like, and then look through actual data collected from the Kepler telescope to vote on whether or not to classify a given signal as a transit, or just noise".
https://en.wikipedia.org/wiki?curid=56324353
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On 21 March 2013, the European-led research team behind the Planck cosmology probe released the mission's all-sky map (565x318 jpeg, 3600x1800 jpeg) of the cosmic microwave background. The map suggests the universe is slightly older than researchers expected. According to the map, subtle fluctuations in temperature were imprinted on the deep sky when the cosmos was about years old. The imprint reflects ripples that arose as early, in the existence of the universe, as the first nonillionth of a second. Apparently, these ripples gave rise to the present vast cosmic web of galaxy clusters and dark matter. Based on the 2013 data, the universe contains 4.9% ordinary matter, 26.8% dark matter and 68.3% dark energy. On 5 February 2015, new data was released by the Planck mission, according to which the age of the universe is billion years old and the Hubble constant was measured to be .
https://en.wikipedia.org/wiki?curid=7376
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For the most recent Global Carbon Budget released in December 2018, the GCP projects fossil CO emissions in 2018 to rise by 2.7% (range 1.8% to 3.7%) to a record 37.1 billion tonnes (Gt) CO, as policy and market forces are currently insufficient to overcome growth in fossil energy use. Atmospheric CO concentration is set to increase by 2.3 ppm [range 2.0 to 2.6 ppm] to reach 407 ppm on average in 2018, 45% above pre-industrial levels. Increases in global use of natural gas and oil are the primary causes of rising atmospheric CO concentrations today. Global coal use will likely increase in 2018 but still remain below its historical peak in 2013. Over the past decade, coal has been displaced by natural-gas-fired, wind, and solar power in some countries.
https://en.wikipedia.org/wiki?curid=11373849
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"The reason for avoiding parallel 5ths and 8ves has to do with the nature of counterpoint. The P8 and P5 are the most stable of intervals, and to link two voices through parallel motion at such intervals interferes with their independence much more than would parallel motion at 3rds or 6ths." "Since the octave really represents a repetition of the same tone in a different register, if two or more octaves occur in succession, the result is a reduction in the number of voices; for example, in a two-voice setting, one of the voices would temporarily disappear, and along with it the rationale of the intended two-voice setting. The octave acts merely as a doubling; if, in a particular instance, it is not intended to act as such, this must be sufficiently emphasized by what precedes and follows it. But even the succession of two octaves brings the sense of doubling into the foreground. Of course, this must not be confused with an intentional doubling used to strengthen sonority, for which, however, strict counterpoint offers no motivation." Similarly, "Parallel 8ves...reduce the number of voices...since the voice that [momentarily] doubles at the 8ve...is not an independent voice but merely a duplication. Parallel 8ves...may also confuse the functions of the voices...If the upper voice succession...is merely a duplication of the bass, then the actual soprano must be...the alto voice. This interpretation of course makes no sense, for it turns the texture inside out." "Parallel 5ths are avoided because the 5th, formed by scale degrees 1 and 5, is the primary harmonic interval, the interval that divides the scale and thus defines the key. The direct succession of two 5ths raises doubt concerning the key."
https://en.wikipedia.org/wiki?curid=1632736
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The Fury has superhuman physical abilities and is virtually indestructible. If damaged, it has self-repair systems, and is capable of developing new powers to deal with unexpected situations. The Fury develops limited teleportation abilities, and when it continues to track the resurrected Captain Britain across realities, it acquires the ability to cross dimensions. Trans-dimensional travel nearly destroys the Fury, and it usually needs to acquire raw "genetic material" to rebuild itself. It is most vulnerable to being destroyed at this time, as its strength, invulnerability and energy blasts are compromised. The Fury can kill regular humans and use their bodies for this purpose, although killing non-superhumans appears to not be a primary function of the Fury.
https://en.wikipedia.org/wiki?curid=1363343
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In 1985, as design shifted to VLSI, Gateway Design Automation introduced Verilog, and Intermetrics released the first completed version of the VHSIC Hardware Description Language (VHDL). VHDL was developed at the behest of the United States Department of Defense's VHSIC program, and was based on the Ada programming language, as well as on the experience gained with the earlier development of ISPS. Initially, Verilog and VHDL were used to document and simulate circuit designs already captured and described in another form (such as schematic files). HDL simulation enabled engineers to work at a higher level of abstraction than simulation at the schematic level, and thus increased design capacity from hundreds of transistors to thousands. In 1986, with the support of the U.S Department of Defense, VHDL was sponsored as an IEEE standard (IEEE Std 1076), and the first IEEE-standardized version of VHDL, IEEE Std 1076-1987, was approved in December 1987. Cadence Design Systems later acquired Gateway Design Automation for the rights to Verilog-XL, the HDL simulator that would become the de facto standard of Verilog simulators for the next decade.
https://en.wikipedia.org/wiki?curid=74554
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Repairs to the damaged ships began immediately, and fresh supplies and ammunition were sent to ready the vessels for action. By October, the Japanese Army had begun to approach Port Arthur, forcing the Chinese to withdraw the Beiyang Fleet to Weihaiwei. Ding sortied on 20 October and crossed the Bohai Strait to Weihaiwei without encountering Japanese forces. In early November, Ding sortied to cover the transfer of "Zhenyuan", which had remained in Port Arthur as long as possible to complete repairs. The Japanese Army had advanced to Weihaiwei by the end of January 1895, launching a major attack on the port on the 30th to begin the Battle of Weihaiwei. They quickly captured the fortifications on the eastern side of the city despite heavy fire from "Dingyuan" and other vessels of the fleet. The capture of the fortresses forced the Chinese ships to withdraw to the western portion of the harbor, where they would be out of range for the guns there. "Dingyuan" disabled one of the disappearing guns in the fortress at Luchiehtsui, but several guns remained on operation, and Japanese gunners quickly set to work to bring them to bear on the trapped fleet. The Chinese ships bombarded Japanese forces as they advanced on the city's defenses.
https://en.wikipedia.org/wiki?curid=2438589
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Although changes to the curriculum could be made quickly, acquisition of aircraft for the school remained a perennial challenge for the school's staff. The Lockheed T-33 Shooting Star arrived in 1953 and became a staple for the students over the next 23 years. More aircraft types were added during the 1950s, including the Republic F-84 Thunderjet, North American F-86 Sabre, North American F-100 Super Sabre, Martin B-57 Canberra, and Convair F-102 Delta Dagger — the school's first delta-winged airplane. In 1955, the school was renamed the U.S. Air Force Flight Test Pilot School, and a year later, moved into its present location on the Main Base facility. This new building, built at a cost of $156,000, was the first and only structure designed specifically for the purposes of the school.
https://en.wikipedia.org/wiki?curid=610257
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In 1993, Carey Gabay, who said he wanted to pursue a "dynamic and grassroots path toward council leadership," was elected as the Undergraduate Council's first Black president. In 1999, Fentrice Driskell was elected as the Undergraduate Council's first Black female president. In 2001, Sujean Lee was elected as the Undergraduate Council's first Asian-American president. Lee's victory as Harvard student body president sparked international media attention, as 20 of South Korea's top broadcasting companies and newspapers covered her win. In 2002, in a symbolic gesture to honor the advancement of gender relations on campus since the integration of Harvard and Radcliffe Colleges, the Council voted to strike "Radcliffe" from its name to simply become the "Harvard Undergraduate Council". Throughout the 2000s, the UC's elections drew relatively high voter turnout (in excess of 50 percent), and the UC was given credit for practical campus life improvements, such as moving final exams to occur before winter break and 24-hour library access.
https://en.wikipedia.org/wiki?curid=31840741
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Most initial approaches have focused on the HIV envelope protein. At least thirteen different gp120 and gp160 envelope candidates have been evaluated, in the US predominantly through the AIDS Vaccine Evaluation Group. Most research focused on gp120 rather than gp41/gp160, as the latter is generally more difficult to produce and did not initially offer any clear advantage over gp120 forms. Overall, they have been safe and immunogenic in diverse populations, have induced neutralizing antibody in nearly 100% recipients, but rarely induced CD8+ cytotoxic T lymphocytes (CTL). Mammalian derived envelope preparations have been better inducers of neutralizing antibody than candidates produced in yeast and bacteria. Although the vaccination process involved many repeated "booster" injections, it was challenging to induce and maintain the high anti-gp120 antibody titers necessary to have any hope of neutralizing an HIV exposure.
https://en.wikipedia.org/wiki?curid=147473
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He then attended Tufts College, like his father before him. A popular student, he was vice president of his sophomore class, and president of his junior class. During his senior year, he managed the football team. He became a member of the Alpha Tau Omega fraternity, and dated Phoebe Clara Davis, who also came from Chelsea. Tufts allowed students to gain a master's degree in four years simultaneously with a bachelor's degree. For his master's thesis, Bush invented and patented a "profile tracer". This was a mapping device for assisting surveyors that looked like a lawn mower. It had two bicycle wheels, and a pen that plotted the terrain over which it traveled. It was the first of a string of inventions. On graduation in 1913 he received both Bachelor of Science and Master of Science degrees.
https://en.wikipedia.org/wiki?curid=32767
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Well-known successful demonstrations of causal evidence consistent across multiple studies with different designs include the identified causal links between smoking and lung cancer, and between blood pressure and stroke. However, there have also been notable failures when exposures hypothesized to be a causal risk factor for a particular outcome were later shown by well conducted randomized controlled trials not to be causal. For instance, it was previously thought that hormone replacement therapy would prevent cardiovascular disease, but it is now known to have no such benefit and may even adversely affect health. Another notable example is that of selenium and prostate cancer. Some observational studies found an association between higher circulating selenium levels (usually acquired through various foods and dietary supplements ) and lower risk of prostate cancer. However, the Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed evidence that dietary selenium supplementation actually increased the risk of prostate and advanced prostate cancer and had an additional off-target effect on increasing type 2 diabetes risk.
https://en.wikipedia.org/wiki?curid=10453294
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Phase separation allows for three-dimensional sub-micrometre fiber scaffolds to be created without the use of specialized equipment. The five steps involved in phase separation are polymer dissolution, phase separation and gelation, solvent extraction from the gel, freezing and freeze drying in water. The final product is a continuous fiber network. Phase separation can be modified to fit many different applications, and pore structure can be varied by using different solvents, which can change the entire process from liquid–liquid to solid–liquid. Porosity and fiber diameter can also be modified by varying the initial concentration of the polymer; a higher initial concentration leads to less pores and larger fiber diameters. This technique can be used to create networks of fibers with diameters reaching type I collagen fiber diameters. The fibrous network created is randomly oriented and so far work has not been done to attempt to organize the fibers. Phase separation is a widely used technique for creating highly porous nanofibrous scaffolds with ease.
https://en.wikipedia.org/wiki?curid=11088829
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Fusion processes require fuel and a confined environment with sufficient temperature, pressure, and confinement time to create a plasma in which fusion can occur. The combination of these figures that results in a power-producing system is known as the Lawson criterion. In stars, the most common fuel is hydrogen, and gravity provides extremely long confinement times that reach the conditions needed for fusion energy production. Proposed fusion reactors generally use heavy hydrogen isotopes such as deuterium and tritium (and especially a mixture of the two), which react more easily than protium (the most common hydrogen isotope), to allow them to reach the Lawson criterion requirements with less extreme conditions. Most designs aim to heat their fuel to around 100 million degrees, which presents a major challenge in producing a successful design.
https://en.wikipedia.org/wiki?curid=55017
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Students successful in early examinations are rewarded by their colleges with scholarships and exhibitions, normally the result of a long-standing endowment, although since the introduction of tuition fees the amounts of money available are purely nominal. Scholars, and exhibitioners in some colleges, are entitled to wear a more voluminous undergraduate gown; "commoners" (originally those who had to pay for their "commons", or food and lodging) are restricted to a short, sleeveless garment. The term "scholar" in relation to Oxford therefore has a specific meaning as well as the more general meaning of someone of outstanding academic ability. In previous times, there were "noblemen commoners" and "gentlemen commoners", but these ranks were abolished in the 19th century. "Closed" scholarships, available only to candidates who fitted specific conditions such as coming from specific schools, were abolished in the 1970s and 1980s.
https://en.wikipedia.org/wiki?curid=31797
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Hindess described the book as "a ponderous polemic" against Marxism, Lenin, and the Bolsheviks. He considered Kołakowski lacking in detachment, and criticized him for not considering alternatives to his view that Marx's thought was a philosophical anthropology settled in its essential features by the time of "The German Ideology", and for relying on "the notion of totalitarianism", which he considered "worthless as a tool of political analysis". He argued that because Kołakowski viewed Marxism as a philosophy he gave insufficient attention to "the use of Marxism as a means of political calculation or to the substantive questions of political and economic analysis posed in numerous Marxist attempts at concrete analysis". He accused Kołakowski of providing misleading discussions of Marxist writers such as Kautsky, and of Lenin's politics and the development of Stalinism. He described Kołakowski's account of Marxism as a "grotesque and offensive caricature" that failed to explain Marxism's impact on the modern world.
https://en.wikipedia.org/wiki?curid=34430017
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ASIMO stands tall and weighs . Research conducted by Honda found that the ideal height for a mobility assistant robot was between 120 cm and the height of an average adult, which is conducive to operating door knobs and light switches. ASIMO is powered by a rechargeable 51.8 V lithium-ion battery with an operating time of one hour. Switching from a nickel metal hydride in 2004 increased the amount of time ASIMO can operate before recharging. ASIMO has a three-dimensional computer processor that was created by Honda and consists of a three stacked die, a processor, a signal converter and memory. The computer that controls ASIMO's movement is housed in the robot's waist area and can be controlled by a PC, wireless controller, or voice commands.
https://en.wikipedia.org/wiki?curid=500894
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Other studios attempted to get into the CGI game. After ending its relationship with Don Bluth, 20th Century Fox released a hugely successful CGI-animated feature in early 2002 entitled "Ice Age", as the first full-length feature film under Blue Sky Studios. In 2001, Paramount offered "", TWC offered "Hoodwinked!" in 2005, and Columbia produced "Open Season" in 2006. Warner Brothers had a major success in 2006 with the Oscar-winning feature film, "Happy Feet", while Sony produced films under Sony Pictures Animation including "Open Season" in 2006, "Surf's Up" in 2007, and the successful film franchises "Cloudy with a Chance of Meatballs" and "Hotel Transylvania" which began in 2009 and 2012, respectively. Universal Studios attempted several times to become a viable participant in the market, finally achieving the goal in 2010 with "Despicable Me", the first feature film from Illumination which provided more hits for them within the following decade. STX Entertainment offered "UglyDolls" in 2019.
https://en.wikipedia.org/wiki?curid=141959
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Multicellularity. Most bacterial species exist as single cells; others associate in characteristic patterns: "Neisseria" forms diploids (pairs), streptococci form chains, and staphylococci group together in "bunch of grapes" clusters. Bacteria can also group to form larger multicellular structures, such as the elongated filaments of "Actinomycetota" species, the aggregates of "Myxobacteria" species, and the complex hyphae of "Streptomyces" species. These multicellular structures are often only seen in certain conditions. For example, when starved of amino acids, myxobacteria detect surrounding cells in a process known as quorum sensing, migrate towards each other, and aggregate to form fruiting bodies up to 500 micrometres long and containing approximately 100,000 bacterial cells. In these fruiting bodies, the bacteria perform separate tasks; for example, about one in ten cells migrate to the top of a fruiting body and differentiate into a specialised dormant state called a myxospore, which is more resistant to drying and other adverse environmental conditions.
https://en.wikipedia.org/wiki?curid=9028799
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Kurt Lewin, a German forerunner of ecological systems models and the founder of modern social psychology, pioneered the use of theory and experimentation to test hypotheses. He focused on the life space, which he defined as a person's psychological activities that occur within a kind of psychological field. The life space that contains all the events in the past, present, and future that shape and affect an individual. This focus on individuality led him to diagram the life space, containing arrows leading to and from possible life goals, both positive and negative. In sum, Lewin's ecological systems model emphasized situational and proximal causes. Additionally, Lewin's theory demonstrates that behavior is a function of the current person by their environment, which are all affected by past experience.
https://en.wikipedia.org/wiki?curid=34112061
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The concept astrolinguistics in scientific research was coined as such, also with a view towards message construction for ETI, in 2013 in the monograph "Astrolinguistics: Design of a Linguistic System for Interstellar Communication Based on Logic," written by the astronomer and computer scientist Alexander Ollongren from the University of Leiden (the Netherlands). This book presents a new Lingua Cosmica totally different from Freudenthal's design. It describes the way the logic of situations in human societies can be formulated in the lingua, also named LINCOS. This astrolinguistic system, also designed for use in interstellar communication, is based on modern constructive logic – which assures that all expressions are verifiable. At a deeper, more fundamental level, however, astrolinguistics is concerned with the question whether linguistic universalia can be identified which are potentially useful in communication across interstellar distances between intelligence species. In the view of the new LINCOS these might be certain logic descriptions of specific situations and relations (possibly in an Aristotelian sense). Kadri Tinn's (Astronomy for Humans) review of Ollongren's book recognised that aspect – she wrote:
https://en.wikipedia.org/wiki?curid=11175098
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Several groups have reported clinical trial results that omalizumab may be effective in patients with non-allergic asthma. This seems to be contrary to the general understanding of the pharmacological mechanisms of the anti-IgE therapy discussed above. Furthermore, among the diseases in which omalizumab has been studied for efficacy and safety, some are not allergic diseases, because hypersensitivity reactions toward external antigens is not involved. For example, a portion of the cases of chronic idiopathic urticaria and all cases of bullous pemphigoid are clearly autoimmune diseases. For the remaining cases of chronic idiopathic urticaria and those of the different subtypes of physical urticaria, the internal abnormalities leading to the disease manifestation have not been identified. Notwithstanding these developments, it is apparent that many of those diseases involve inflammatory reactions in the skin and the activation of mast cells. An increasing series of papers have shown that IgE potentiates the activities of mast cells and omalizumab can function as a mast cell-stabilizing agent, rendering these inflammatory cells to be less active.
https://en.wikipedia.org/wiki?curid=1255131
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One of the better documented cultural norms that augment gender disparities in health is the preference for sons. In India, for instance, the 2001 census recorded only 93 girls per 100 boys. This is a sharp decline from 1961, when the number of girls per 100 boys was nearly 98. In certain parts of India, such as Kangra and Rohtak the number of girls for every 100 boys can be as low as in the 70s. Additionally, low female to male numbers have also been recorded in other Asian countries – most notably in China where, according to a survey in 2005, only 84 girls were born for every 100 boys. Although this was a slight increase from 81 during 2001–2004, it is still much lower than the 93 girls per 100 boys in the late 1980s. The increasing number of unborn girls in the late 20th century has been attributed to technological advances that made pre-birth sex determination, also known as prenatal sex discernment, such as the ultrasound test more affordable and accessible to a wider population. This allowed parents who prefer a son to determine the sex of their unborn child during the early stages of pregnancy. By having early identification of their unborn child's sex, parents could practice sex-selective abortion, where they would abort the fetus if it was not the preferred sex, which in most cases is that of the female.
https://en.wikipedia.org/wiki?curid=38846583
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"São Paulo" made two trips to Europe in 1920. The first conveyed King Albert I and Queen Elisabeth of Belgium to Brazil for the centennial celebrations. After "São Paulo" brought them home, the ship traveled to Portugal to take the bodies of the formerly-exiled Emperor Pedro II and his wife, Teresa Cristina, back to Brazil. In July 1922, both battleships helped to quash the first of the Tenente revolts ("Revolução Tenentista"), in which the garrison of Rio de Janeiro's Fort Copacabana rebelled and began bombarding the city. "São Paulo" shelled the fort, and the rebels surrendered shortly thereafter; "Minas Geraes" did not fire its guns. In 1924, three lieutenants, including Hercolino Cascardo, took over "São Paulo" with other crewmen. They were unsuccessful in swaying any other ships to their cause, except for an old torpedo boat, and soon sailed out of the harbor after firing a six-pounder gun at "Minas Geraes". Short of food and with condensers in poor condition, the rebels sailed to Montevideo, where they received asylum. "Minas Geraes" followed "São Paulo", arriving on 11 November and taking back possession of the ship.
https://en.wikipedia.org/wiki?curid=29900534
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MCC is a form of the Bénard cell where the fluid will rise or fall in hexagonal cells creating hexagonal cloud structure. The capping inversion of the planetary boundary layer acts as a lid for the convection creating a horizontal plane for the hexagonal cloud structures. Satellite observations have been imperative for understanding the horizontal scale and the vertical scale of these cloud formations. MCC is generally too small for synoptic scale measurements, but too large for single point measurements. However, satellite observations are able to monitor the development of the cloud patterns because of their large field of view. Satellites images from TIROS helped to highlight one of the main differences between laboratory convection cells and those that occur in the atmosphere. The ratio of the diameter of the hexagon compared to the depth of the cloud was much larger in the atmosphere compared to the same ratio calculated in controlled experiments. This difference showed that viscosity and heat conduction were important for the laboratory measurements, but eddy diffusion of heat and momentum dominated the atmospheric cells. Wind shear must be low to form MCC cells otherwise cloud streaks will form in the direction of the wind shear. The cloud formations that occur as part of MCC can be placed into two categories: open cells and closed cells.
https://en.wikipedia.org/wiki?curid=43076961
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First steps to establish the CIEE were taken in 2007 at the inaugural meeting of the Canadian Society for Ecology and Evolution, the national learned society. In May 2008, after a nationwide competition that received entries from some of Canada's most prestigious universities, the Society's Governing Council selected the proposal from the University of Toronto to house and operate the CIEE at the Koffler Scientific Reserve under the direction of Prof. Arthur E. Weis. In 2012 Dr. Peter Leavitt was appointed Director and administration of CIEE moved to the University of Regina (while programming continued to be distributed around the country). the CIEE was housed at the Institute of Environmental Change and Society (IECS) at the University of Regina. the CIEE is located at the UBC Biodiversity Research Centre in Vancouver. Diane Srivastava was appointed Director in 2017.
https://en.wikipedia.org/wiki?curid=27635333
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The first F-5E flew on 11 August 1972. A two-seat combat-capable trainer, the F-5F, was offered, first flying on 25 September 1974, at Edwards Air Force Base, with a new nose, that was three feet longer, which, unlike the F-5B that did not mount a gun, allowed it to retain a single M39 cannon, albeit with a reduced ammunition capacity. The two-seater was equipped with the Emerson AN/APQ-157 radar, which is a derivative of the AN/APQ-153 radar, with dual control and display systems to accommodate the two-men crew, and the radar has the same range of AN/APQ-153, around 10 nmi. On 6 April 1973, the 425th TFS at Williams Air Force Base, Arizona, received the first F-5E Tiger II.
https://en.wikipedia.org/wiki?curid=11142
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As technology improves, it may soon be possible for mobile phones or other devices to sense when people are changing state (e.g. entering a manic or a deeply depressed phase), for instance by noticing a change in voice pattern or usage frequency, or facial tension. It may also become possible to measure physical evidence of levels of distress and suffering, such as changes in hormones or adrenalin in blood, and changes in brain activity. Apps may also be able to predict high stress situations, based on location, time, activity (e.g. purchasing of alcohol) and nearby presence of high risk people. The technology could then send calming messages to patients, automatically alert carers and even automatically administer meds.
https://en.wikipedia.org/wiki?curid=31300489
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Earth Surface Processes and Landforms is a peer-reviewed scientific journal published by John Wiley & Sons on behalf of the British Society for Geomorphology. It covers geomorphology and more in general all aspects of Earth sciences dealing with the Earth surface. The journal was established in 1976 as Earth Surface Processes, obtaining its current name in 1981. The journal primarily publishes original research papers. It also publishes "Earth Surface Exchanges" which include commentaries on issues of particular geomorphological interest, discussions of published papers, shorter journal articles suitable for rapid publication, and commissioned reviews on key aspects of geomorphological science. Foci include the physical geography of rivers, valleys, glaciers, mountains, hills, slopes, coasts, deserts, and estuary environments, along with research into Holocene, Pleistocene, or Quaternary science. The editor-in-chief is Stuart Lane (University of Lausanne).
https://en.wikipedia.org/wiki?curid=12592529
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Established in 1929, the Queensland Society of Sugar Cane Technologists held its first conference at Cairns in 1930, convened by Norman Bennett of the Bureau of Sugar Experiment Stations. This was after preliminary meetings of the representatives of 16 sugar mills, six engineering firms and the Central Cane Prices Board. Other absentee mill owners were reputedly uncertain about disclosing trade secrets that such an alliance might bring but the formation of the group was in the face of "stark ruin, with overseas prices on which cheap labour countries could not exist. To some it appeared that the expansion of the previous period had been a mistake..." a situation which was to repeat in years to come. By 1948 both the Queensland Cane Growers' Council and the Australian Sugar Producers' Association were again concerned and angry because the Bureau had lost a string of highly skilled personnel [including two directors], to more highly paid jobs.
https://en.wikipedia.org/wiki?curid=49038469
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In 1982, A. Thomas Brown, M '77, like Brother Barth, a member's son, was elected Grand Regent. During 1983, Theta Tau purchased its first computer; moved the central office from the Executive Secretary's home to space in the Theta Xi Memorial Headquarters Building in the St. Louis suburb of Creve Coeur; held its first National Conference; and first employed a second member, Dean W. Bettinger, T '81, as Extension Director/Chapter Consultant. Since then, others have been employed for limited periods, including Michael T. Abraham, EB '92, who served as administrative assistant in 1988 and briefly in 1989.
https://en.wikipedia.org/wiki?curid=362188
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These issues were addressed by a small UK company, Eidos Interactive. Eidos chose the new ARM-based computers from the UK and implemented an editing system, launched in Europe in 1990 at the International Broadcasting Convention. Because it implemented its own compression software designed specifically for non-linear editing, the Eidos system had no requirement for JPEG hardware and was cheap to produce. The software could decode multiple video and audio streams at once for real-time effects at no extra cost. But most significantly, for the first time, it supported unlimited cheap removable storage. The Eidos Edit 1, Edit 2, and later Optima systems let the editor use "any" Eidos system, rather than being tied down to a particular one, and still keep his data secure. The Optima software editing system was closely tied to Acorn hardware, so when Acorn stopped manufacturing the Risc PC in the late 1990s, Eidos discontinued the Optima system.
https://en.wikipedia.org/wiki?curid=70729
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The use of combined sewer systems to treat excess rainwater runoff is common in older urban areas. The Combined Sewer System (CSS) collects rainwater runoff, domestic sewage and industrial wastewater into a single pipe. Combined sewer overflows (CSOs) occur when untreated wastewater is discharged to surface water beyond its hydraulic capacity, when this occurs, untreated rainwater and wastewater are discharged directly into nearby streams, rivers and other water bodies. Combined sewer overflows (CSOs) contain untreated or partially treated human and industrial waste, toxic materials and debris, and rainwater. a problem that is currently a key challenge for rainwater management and can lead to public health incidents. Gray-green infrastructure is the key technology to solve this problem and is the core technology of the currently introduced "sponge city". The implementation of gray infrastructure, such as upgrading drainage networks, storage facilities or pumping stations with large diameter pipes, is critical to drain rainwater from urban catchments, while most green infrastructure handles the storage and infiltration of rainwater and drainage of gray infrastructure
https://en.wikipedia.org/wiki?curid=69500966
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Typical dementia screening tests used are the Mini–Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). The pattern of cognitive impairment in DLB is distinct from other dementias, such as AD; the MMSE mainly tests for the memory and language impairments more commonly seen in those other dementias and may be less suited for assessing cognition in the Lewy body dementias, where testing of visuospatial and executive function is indicated. The MoCA may be better suited to assessing cognitive function in DLB, and the Clinician Assessment of Fluctuation scale and the Mayo Fluctuation Composite Score may help understand cognitive decline relative to fluctuations in DLB. For tests of attention, digit span, serial sevens, and spatial span can be used for simple screening, and the Revised Digit Symbol Subtest of the Wechsler Adult Intelligence Scale may show defects in attention that are characteristic of DLB. The Frontal Assessment Battery, Stroop test and Wisconsin Card Sorting Test are used for evaluation of executive function, and there are many other screening instruments available.
https://en.wikipedia.org/wiki?curid=227167
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In his attempts to finance the printing of the tables, Kepler began by claiming the arrears due to him by Rudolph. From the Imperial Court in Vienna he was sent to three other towns to which the debt was transferred. After a year of roaming the country, he was eventually able to raise 2000 florins (out of 6299 owed to him), which sufficed to pay for the paper. He paid for the printing out of his own pocket. It was initially supposed to be printed in Linz, where he resided at the time, but the chaos of the Thirty Years' War (first the garrisoning of soldiers in the town, after which a siege of the revolting peasantry, which almost resulted in the burning of the manuscript) prompted him to leave. He began the enterprise anew in Ulm. There, after many quarrels with the printer Jonas Saur, the first edition of a thousand copies was completed in September 1627, in time for the annual book mart in the Frankfurt Fair.
https://en.wikipedia.org/wiki?curid=3288669
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In 2017, Thailand produced 122,593 tonnes of tomatoes. The northeast produces 55 percent; the north, 32 percent; and the central region, 13 percent. The highest yielding provinces are Chiang Mai, Sakon Nakhon, Nakhon Phanom, and Nong Khai. Growing tomatoes in prime areas can generate profits of up to 40,000 baht per rai. The northeast's contribution is in jeopardy due to the construction of upstream dams on the Mekong River. The dams have depleted river banks of nutrition-rich sediments and have produced unseasonal inundations as dams release water in the dry season to maintain power generation and river navigation. Samples from Chiang Mai 1994, analysed by Nishimura et al 1999, showed "Phytophthora infestans" of only one type, the A1 (specifically US-1) population, on tomato. Petchaboon et al 2014 analysed 53 samples from 2000-2002, and found them all to be A1, and of those all but one were US-1 clonal lineages, agreeing with the above results of Nishimura and also Gotoh et al 2005.
https://en.wikipedia.org/wiki?curid=3467679
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As mentioned earlier, light can be an environmental factor that stimulates the germination process. The seed needs to be able to determine when is the perfect time to germinate and they do that by sensing environmental cues. Once germination starts, the stored nutrients that have accumulated during maturation start to be digested which then supports cell expansion and overall growth. Within light-stimulated germination, Phytochrome B (PHYB) is the photoreceptor that is responsible for the beginning stages of germination. When red light is present, PHYB is converted to its active form and moves from the cytoplasm to the nucleus where it upregulates the degradation of PIF1. PIF1, phytochrome-interaction-factor-1, negatively regulates germination by increasing the expression of proteins that repress the synthesis of gibberellin (GA), a major hormone in the germination process. Another factor that promotes germination is HFR1 which accumulates in light in some way and forms inactive heterodimers with PIF1.
https://en.wikipedia.org/wiki?curid=227478
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At tournaments, especially those hosted by the International Brazilian Jiu-Jitsu Federation (IBJJF), some athletes engage in a practice called "closing out". This occurs when two athletes, usually friends or members of the same team, meet in a match but refuse to fight. Tournament organizers can minimize the chance of close-outs by placing athletes from the same team on opposite sides of the bracket, a practice which makes the finals the only match in which they could possibly meet (assuming each team has no more than two competitors in a given bracket). When two athletes close out a match, they agree which one of them will technically forfeit to the other. As this most often occurs in the final matches of tournaments, this usually means deciding which of the two will win the gold medal and which will win the silver. Notable examples of closing out include Marcus "Buchecha" Almeida forfeiting the finals of the Absolute division at the 2018 IBJJF World Championship to his friend Leandro Lo, who had suffered a shoulder injury during a previous match, and frequent close outs between the brothers Paulo and Joao Miyao, who often compete in the same weight division.
https://en.wikipedia.org/wiki?curid=207083
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Daniel Barton Oerther (born October 11, 1972) is an American professor. He is best known for leadership bridging engineering and nursing to advance environmental health practice through science diplomacy. Oerther uses 16S ribosomal RNA-targeted techniques for fundamental studies of the ecology of bacteria in engineered and natural systems. He promotes transdisciplinarity among engineers, nurses, and sanitarians to improve access to clean water, nutritious food, and energy efficiency in developing communities. Oerther practices innovation in the scholarship of teaching and learning, including modified mastery learning.
https://en.wikipedia.org/wiki?curid=43396814
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Lectures every Tuesday evening from September to May, on a wide variety of topics, have been a key feature of the Institution's activities since its foundation in 1839. Past lecturers have included (in alphabetical order): Joan Bakewell, Michael Berkeley, Walter Besant, John Betjeman, Anthony Blunt, Ronald Blythe, Thomas Brimelow, Sophie Bryant, AS Byatt, Hugh Casson, William Dalrymple, Charles Dickens Jr., Margaret Drabble, Lord Dufferin, Millicent Garrett Fawcett, Roger Fenton, Michael Foot, Antonia Fraser, Michael Frayn, Lord Justice Fry, Timothy Garton Ash, Misha Glenny, Jane Glover, Edmund Gosse, Andrew Graham Dixon, George Grossmith, Simon Hoggart, Richard Holmes, Michael Holroyd, Tristram Hunt, Simon Jenkins, Steve Jones, Jim Al-Khalili, Mary Kingsley, Hermione Lee, David Lodge, Richard Mabey, Hilary Mantel, Henry Marsh, Eleanor Marx, Jonathan Miller, Frank Muir, James Murray, Julia Neuberger, Paul Nurse, Michael Palin, Flinders Petrie, Lady Plowden, Roy Porter, Michael Rosen, Mark Rylance, Marcus du Sautoy, Quentin Skinner, David Starkey, Sergius Stepniak, John Summerson, AJP Taylor, Colin Thubron, Claire Tomalin, Arthur Waley, Fergus Walsh, Marina Warner, Sydney Waterlow, Huw Weldon, Mortimer Wheeler and Lewis Wolpert.
https://en.wikipedia.org/wiki?curid=66305584
2,053,292
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Effective political support is necessary for ecologically sustainable development. The mobilization of governments can be translated into action plans that are crucial to sustainable development. Development efforts can be influenced by patterns of family arrangements, work attitudes, social morality—particularly interpersonal responsibilities, hierarchy of authority, quality of scientific education and implementation, and degree of domestic stability—especially, freedom from social conflict. National policy and development planning requires three conditions to permit ecological sustainability: action-oriented values to which individuals are committed, political authorities that favour long-term ecological benefits over immediate economic gains, and a policy with a politically competent constituency.
https://en.wikipedia.org/wiki?curid=7318603
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Noctis Labyrinthus, on the western edge of the Valles Marineris Rift System, north of the Syria Planum and east of Pavonis Mons, is a jumbled terrain composed of huge blocks which are heavily fractured. It also contains canyons that run in different directions surrounding large blocks of older terrain. Most of the upper parts of the blocks are composed of younger fractured material thought to be of volcanic origin associated with the Tharsis bulge. The other tops are composed of older fractured material thought also to be volcanic in origin, but differentiated from the younger material by more ruggedness and more impact craters. The sides of the blocks are composed of undivided material thought to be basement rock. The space between the blocks is composed mainly of either rough or smooth floor material. The rough floor material tends to be in the eastern portion of the Noctis Labyrinthus and is thought to be debris from the walls or maybe eolian features covering rough topography and landslides. The smooth floor material is thought to be composed of fluvial or basaltic material and/or eolian features covering an otherwise rough and jumbled terrain. Terrains such as Noctis Labyrinthus are commonly found at the head of outflow channels, like the one explored by the Pathfinder mission and its Sojourner rover. They are interpreted to be a place of downward block faulting associated with the removal of ground fluid in catastrophic flood sequences. The fluid could be either carbon-dioxide ice and gas, water or lava. The hypothesis of lava involvement is associated with a proposal that Noctis Labyrinthus is directly connected to lava tubes on the slope of Pavonis Mons.
https://en.wikipedia.org/wiki?curid=91176
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The presence of surface charge imbalance means that the objects will exhibit attractive or repulsive forces. This surface charge imbalance, which yields static electricity, can be generated by touching two differing surfaces together and then separating them due to the phenomena of contact electrification and the triboelectric effect. Rubbing two nonconductive objects generates a great amount of static electricity. This is not just the result of friction; two nonconductive surfaces can become charged by just being placed one on top of the other. Since most surfaces have a rough texture, it takes longer to achieve charging through contact than through rubbing. Rubbing objects together increases the amount of adhesive contact between the two surfaces. Usually insulators, i.e., substances that do not conduct electricity, are good at both generating, and holding, a surface charge. Some examples of these substances are rubber, plastic, glass, and pith. Conductive objects rarely generate charge imbalance, except when a metal surface is impacted by solid or liquid nonconductors. The charge that is transferred during contact electrification is stored on the surface of each object. Electrostatic generators, devices which produce very high voltage at very low current and used for classroom physics demonstrations, rely on this effect.
https://en.wikipedia.org/wiki?curid=368328
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Wavefront-guided LASIK is a variation of LASIK surgery in which, rather than applying a simple correction of only long/short-sightedness and astigmatism (only lower order aberrations as in traditional LASIK), an ophthalmologist applies a spatially varying correction, guiding the computer-controlled excimer laser with measurements from a wavefront sensor. The goal is to achieve a more optically perfect eye, though the result still depends on the physician's success at predicting changes that occur during healing and other factors that may have to do with the regularity/irregularity of the cornea and the axis of any residual astigmatism. Another important factor is whether the excimer laser can correctly register eye position in 3 dimensions, and to track the eye in all the possible directions of eye movement. If a wavefront guided treatment is performed with less than perfect registration and tracking, pre-existing aberrations can be worsened. In older patients, scattering from microscopic particles (cataract or incipient cataract) may play a role that outweighs any benefit from wavefront correction.
https://en.wikipedia.org/wiki?curid=417929
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The flying portion of FIP was typically conducted by civilian instructors under USAF contract at a nearby civilian airport, normally employing light general aviation aircraft such as the Cessna 150 / Cessna 152 series, Cessna 172, Piper Cherokee, or other similar aircraft. Since FIP was designed as a washout/attrition device, AFROTC cadets who already held an FAA Private Pilot's Certificate or greater were not eligible for any actual flight time via FIP. Those cadets without prior flight experience initially received 38 flight hours, but post-Vietnam War defense cutbacks in the mid-1970s resulted in FIP being reduced to a "safe for solo" program with 25 hours of funded flight time. FIP was discontinued in 1991 when it was replaced by the single-site Enhanced Flight Screening Program (EFSP) at Hondo, Texas.
https://en.wikipedia.org/wiki?curid=1240787
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In 1957, Kirsch's group developed a digital image scanner, to "trace variations of intensity over the surfaces of photographs", and made the first digital scans. One of the first photographs scanned, a picture of Kirsch's three-month-old son, was captured as just 30,976 pixels, a 176 × 176 array, in an area 5 cm × 5 cm (2" x 2"). The bit depth was only one bit per pixel, stark black and white with no intermediate shades of gray, but, by combining several scans made using different scanning thresholds, grayscale information could also be acquired. They used the computer to extract line drawings, count objects, recognize alphanumeric characters, and produce oscilloscope displays. He also proposed the Kirsch operator for edge detection in images.
https://en.wikipedia.org/wiki?curid=26930518
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GC uses computing resources to decide which memory to free. Therefore, the penalty for the convenience of not annotating object lifetime manually in the source code is overhead, which can impair program performance. A peer-reviewed paper from 2005 concluded that GC needs five times the memory to compensate for this overhead and to perform as fast as the same program using idealised explicit memory management. The comparison however is made to a program generated by inserting deallocation calls using an oracle, implemented by collecting traces from programs run under a profiler, and the program is only correct for one particular execution of the program. Interaction with memory hierarchy effects can make this overhead intolerable in circumstances that are hard to predict or to detect in routine testing. The impact on performance was given by Apple as a reason for not adopting garbage collection in iOS, despite it being the most desired feature.
https://en.wikipedia.org/wiki?curid=6734
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where formula_5 is a vector with formula_9 entries (i.e. formula_25), formula_6 is a vector with formula_10 entries (i.e. formula_28), formula_8 is small and positive, and formula_1, formula_2, formula_3 are smooth (i.e. infinitely differentiable). Additional constraints are required to guarantee parabolic bursting. First, formula_33 must produce a circle in phase space that is invariant, meaning it does not change under certain transformations. This circle must also be attracting in formula_34 with a critical point located at formula_35. The second criterion requires that when formula_36, there exists a stable limit cycle solution. These criteria can be summarized by the following points:
https://en.wikipedia.org/wiki?curid=34038330
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The REST architectural style is designed for network-based applications, specifically client-server applications. But more than that, it is designed for Internet-scale usage, so the coupling between the user agent (client) and the origin server must be as lightweight (loose) as possible to facilitate large-scale adoption. This is achieved by creating a layer of abstraction on the server by defining resources that encapsulate entities (e.g. files) on the server and so hiding the underlying implementation details (file server, database, etc.). But the definition is even more general than that: any information that can be named can be a resource: an image, a database query, a temporal service (e.g. “today’s weather in London”), or even a collection of other resources. This approach allows the greatest interoperability between clients and servers in a long-lived Internet-scale environment which crosses organisational (trust) boundaries.
https://en.wikipedia.org/wiki?curid=907222
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For humans, as in most mammalian populations, MHC Class I molecules are extremely variable in their primary structure, and HLA-A is ranked among the genes in humans with the fastest-evolving coding sequence. As of March 2022, there are 7,452 known HLA-A alleles coding for 4,305 active proteins and 375 null proteins.This level of variation on MHC Class I is the primary cause of transplant rejection, as random transplantation between donor and host is unlikely to result in a matching of HLA-A, B or C antigens. Evolutionary biologists also believe that the wide variation in HLAs is a result of a balancing act between conflicting pathogenic pressures. Greater variety of HLAs decreases the probability that the entire population will be wiped out by a single pathogen as certain individuals will be highly resistant to each pathogen. The effect of HLA-A variation on HIV/AIDS progression is discussed below.
https://en.wikipedia.org/wiki?curid=7718899
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The observatory is a sandstone two-storey building in the Italianate style. There are two telescope domes on octagonal bases and a four-storey tower for the time-ball. The 1858 building designed by the Colonial Architect, Alexander Dawson, comprised a dome to house the equatorial telescope, a room with long, narrow windows for the transit telescope, an office for calculations, and a residence for the astronomer. A western wing was added in 1877 with office and library space and a second dome for another telescope. Some of the first astronomical photographs of the southern sky were taken at the observatory, under the direction of Henry Chamberlain Russell. The observatory also took part in the compilation of the first atlas of the whole sky, "The astrographic catalogue". The part completed at Sydney took over 70 years, from 1899 to 1971, and filled 53 volumes. The observatory once contained offices, instruments, a library and an astronomer's residence. It is now a public observatory and a museum of astronomy and meteorology.
https://en.wikipedia.org/wiki?curid=3911092
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The HERTI UAV started flight trials in Australia in late 2004. Since then, quite a few key points have been addressed, however, slightly slower than BAE Systems wanted to. The two main test centres are the Woomera range in central Australia and the West Sale airbase which is in south-east Australia. In late 2006 a HERTI vehicle flew several fully autonomous missions from the Woomera test centre to expand the flight envelope, or distance and height limits to which the UAV has flown in real tests. In mid-2007 BAE Systems started a flight campaign to increase the flight envelope even further, this time from West Sale airbase. In these trials the HERTI UAV should fly 28 km from base and at altitudes of about To achieve a UAV that can safely fly within civilian airspace, BAE Systems is developing a "sense and avoid" system for HERTI, utilising a radar and electro-optical systems.
https://en.wikipedia.org/wiki?curid=14512017
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In college Beranek became friends with a fellow student who had an amateur radio setup, inspiring him to study Morse Code and to earn his own amateur radio license. In fall of 1933, he bought an early disc sound recorder to earn a modest fee by recording students before and after taking a speech training class. This was his first hands-on experience with the developing science of acoustics. By early 1934 he was forced to drop out of college and work full-time to earn more tuition money. He found a position at the fledgling Collins Radio Company of Cedar Rapids, Iowa, where he studied German in his spare time. While there, he also met and dated Florence "Floss" Martin, a business school student. He was able to save enough money to attend the Spring 1935 semester at Cornell College, then returned to Collins Radio for the summer.
https://en.wikipedia.org/wiki?curid=3255483
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In 2009, Christakis' group began to study the evolutionary biology and genetics of social networks, publishing in "PNAS" a finding that social network position may be partially heritable, and specifically that an increase in twins' shared genetic material corresponds to differences in their social networks. In 2011, a follow-up paper on "Correlated Genotypes in Friendship Networks" in "PNAS" advanced the argument that humans may be "metagenomic" with respect to the people around them. Further work on this topic included "Friendship and Natural Selection" in "PNAS" in 2014, showing that people have a small but discernible preference for choosing as their friends other people who resemble them roughly as much as third or fourth cousins. In 2012, in a paper in "Nature", Christakis' group analyzed the social networks of the Hadza hunter-gatherers, showing that human social network structure appears to have ancient origins. Christakis and his colleagues did similar work mapping the networks of the Nyangatom people of Sudan in 2016. His group has also demonstrated that social networks are deeply related to human cooperation. These ideas are explored in Christakis' 2019 book, "Blueprint: The Evolutionary Origins of a Good Society".
https://en.wikipedia.org/wiki?curid=21566523
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As Atari faced more competition in both arcade and home consoles from 1975 onward, Bushnell recognized that the costs in developing both types of systems with only limited shelf life were too high, and directed Atari's engineers at Cyan Engineering towards a programmable home console. This console eventually was released in 1977 as the Atari Video Computer System or Atari VCS and later known as the Atari 2600. However, before Atari had completed its design, the Fairchild Channel F, the first home console to use game cartridges, was released in November 1976. Bushnell realized they needed to speed up the Atari VCS's development. After initially considering become a public company, he instead sought a buyer. Warner Communications, looking to boost their own failing media properties, agreed to acquire Atari for , with Bushnell personally receiving , in November 1976. Warner provided a large investment into the Atari VCS to allow it to be completed early the next year and released in September 1977.
https://en.wikipedia.org/wiki?curid=77245
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Education and the psychology of cognitive development converge on a number of crucial assumptions. First, the psychology of cognitive development defines human cognitive competence at successive phases of development. That is, it specifies what aspects of the world can be understood at different ages, what kinds of concepts can be constructed, and what types of problems can be solved. Education aims to help students acquire knowledge and develop skills which are compatible with their understanding and problem-solving capabilities at different ages. Thus, knowing the students' level on a developmental sequence provides information on the kind and level of knowledge they can assimilate, which, in turn, can be used as a frame for organizing the subject matter to be taught at different school grades. This is the reason why Piaget's theory of cognitive development was so influential for education, especially mathematics and science education.
https://en.wikipedia.org/wiki?curid=25076961
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The small differences between the two subtypes of ER have been used to develop subtype-selective ER modulators, but the high similarity between the two receptors make the development very challenging. Amino acids in the ligand-binding domains differ at two positions, Leu-384 and Met-421 in ERα and Met-336 and Ile-373 in ERβ, but they have similar hydrophobicity and occupying volumes. However, the shapes and the rotational barrier of the amino acid residues are not the same, leading to distinguish α- and β-face of the binding cavity between ERα and ERβ. This causes ERα-preferential-binding of ligand substituents that are aligned downwards facing Met-336 while ligand substituents aligned upwards facing Met-336 are more likely to bind to ERβ. Another difference is in Val-392 in ERα, which is replaced by Met-344 in ERβ. ERβ's binding pocket volume is slightly smaller and the shape a bit different from ERα's. Many ERβ-selective ligands have a largely planar arrangement as the binding cavity of ERβ is slightly narrower than that of ERα, however, this by itself leads to modest selectivity. To attain strong selectivity, the ligand must place substituents very close to one or more of the amino acid differences between ERα and ERβ in order to create a strong repulsive force towards the other subtype receptor. In addition, the structure of the ligand must be rigid. Repulsive interactions may otherwise lead to conformational change of the ligand and, therefore, creating alternative binding modes.
https://en.wikipedia.org/wiki?curid=1088710
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While deep learning has been applied to many different scenarios: context-aware, sequence-aware, social tagging etc. its real effectiveness when used in a simple collaborative recommendation scenario has been put into question. A systematic analysis of publications applying deep learning or neural methods to the top-k recommendation problem, published in top conferences (SIGIR, KDD, WWW, RecSys), has shown that on average less than 40% of articles are reproducible, with as little as 14% in some conferences. Overall the study identifies 18 articles, only 7 of them could be reproduced and 6 of them could be outperformed by much older and simpler properly tuned baselines. The article also highlights a number of potential problems in today's research scholarship and calls for improved scientific practices in that area. Similar issues have been spotted also in sequence-aware recommender systems.
https://en.wikipedia.org/wiki?curid=480289
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The George W. Bush administration showed much interest in developing hydrogen fuel cell technologies within the transportation sector. This interest was mainly driven by the desire to decrease the United States' dependence on foreign oil and reduce the environmental impact of the transportation sector. The initiative to promote fuel cell technology was announced by former President Bush in his State of the Union Address in 2003. Former President Bush stated: "With a new national commitment, our scientists and engineers will overcome obstacles ... so that the first car driven by a child born today could be powered by hydrogen, and pollution-free. Join me in this important innovation to make our air significantly cleaner, and our country much less dependent on foreign sources of energy."
https://en.wikipedia.org/wiki?curid=30832113
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In 1956 he was elected a Fellow of the Royal Society for ""his work on the borderline between physics and chemistry about the adsorption of gases on surfaces, on catalysis and on the processes occurring in photographic emulsions. With the latter end in view he has investigated in some detail the properties of silver halide crystals; he was the first to demonstrate networks of dislocations in a transparent crystal by making silver precipitate along them so that they become visible under the microscope. He has also shown by careful experimental work the role of the dislocations in providing sensitivity centres and their relation to such sensitisers as silver bromide. He has shown why the grains of the emulsions grow in a plate-like form with the octahedral faces exposed, and demonstrated the presence in such crystals of three dislocations meeting in a point, which determines the crystal form.""
https://en.wikipedia.org/wiki?curid=53410514
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The skull of "Oviraptor" was deep and shortened with large fenestrae (openings) compared to other dinosaurs, and measures about long as preserved. The actual length may actually be longer though, given that the holotype skull lacks several regions such as the premaxilla. The holotype skull lacks a crest in almost its entirety, however, the top surfaces of the fused parietal and frontal bones indicate that it likely had a well-developed crest, supported by the nasal and premaxilla bones (mainly the latter) of the rostrum. "Oviraptor" had an elongated maxilla and dentary, which may result into a more extended snout compared to the highly stocky jaws of other oviraptorids. The palate is rigid, extended below the jaw line and formed by the premaxillae, vomers, and maxillae. As in other oviraptorids, it may have had a pair of tooth-like projections on the palate that were directed downwards. As in other oviraptorids, the nares (external nostrils) would have been relatively small and placed high on the skull. "Oviraptor" had toothless jaws that ended in a robust, parrot-like rhamphotheca (horny beak). The curvature of the dentary tip was down-turned but less pronounced than other oviraptorids, such as "Citipati". As a whole, the lower jaw is a short and deep bone that covers .
https://en.wikipedia.org/wiki?curid=581471
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The work of Esslinger and his group has stimulated an interdisciplinary exchange between the condensed-matter and quantum-gas communities. Recent notable results include the development of a quantum simulator for graphene, setting up of a cavity-optomechanical system in which the Dicke quantum phase transition to a superradiant state has been observed for the first time, as well as creation of a cold-atom analogue of mesoscopic conductors and observation of the onset of superfluidity in that system. Esslinger received a Phillip Morris Research Prize (shared with Theodor Hänsch and Immanuel Bloch) in 2000 and currently holds an ERC advanced grant. He is an author on more than 80 peer-reviewed journal articles, which have been cited more than 8000 times (as of March 2013).
https://en.wikipedia.org/wiki?curid=38908567
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