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Upon discovery, Owen presumed that "Gorgonops" and several other taxa he described from the Karoo Supergroup were cold-blooded reptiles, despite bearing teeth resembling those of carnivorous mammals. He proposed classifying all of them under the newly coined order Theriodontia (which he placed in the class Reptilia). He decided to subdivide Theriodontia into families based on the anatomy of the nostrils (the bony narials)—"Mononarialia" for those with one opening in the skull for the nose as in mammals, "Binarialia" for those with two openings as in reptiles, and "Tectinarialia" for "Gorgonops" because its opening was overshadowed by a thick bone roof ("tectus" is Latin for "covered, roofed, decked"). In 1890, English naturalist Richard Lydekker made "Gorgonops" the type species of the family Gorgonopsidae. British palaeontologist Harry Seeley in 1895 believed "Gorgonops" lacked an opening in the temporal bone (temporal fenestra), which is a diagnostic feature of Theriodontia, and so elevated Gorgonopsidae to Gorgonopsia, distinct from Theriodontia. He classified all South African materials bearing both reptilian and mammalian traits into the order "Theriosuchia", and considered Gorgonopsia and Theriodontia suborders of it. American palaeontologist Henry Fairfield Osborn completely reworked the classification of Reptilia in 1903, and erected two major groups: Diapsida and Synapsida, and in 1905, South African palaeontologist Robert Broom created a third group, Therapsida, to house the "mammal-like reptiles", including Theriodontia. He also challenged Seeley's claim and relegated "Gorgonops" back to Theriodontia, but he placed it into his newly erected subgroup Therocephalia, dissolving Gorgonopsia. In 1913, especially in light of an almost complete "G. torvus" skull discovered by the Reverend John H. Whaits, Broom reinstated Gorgonopsia.
https://en.wikipedia.org/wiki?curid=3705573
916,072
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The WRZ and SHZ are associated with the "southern Washington Cascades conductor" (SWCC), a formation of enhanced electrical conductivity lying roughly between Riffe Lake and Mounts St. Helens, Adams, and Rainier, with a lobe extending north (outlined in yellow, right). This formation, up to 15 km thick, is largely buried (from one to ten kilometers deep), and known mainly by magnetotellurics and other geophysical methods. The southwestern boundary of the SWCC, where it is believed to be in near vertical contact with the Eocene basalts of the Crescent Formation, forms a good part of the 90 km (56 mile) long SHZ. On the eastern side, where the SWCC is believed to be in contact with pre-Tertiary terranes accreted to the North American craton, matters are different. While there is a short zone (not shown) of fainter seismicity near Goat Rocks (an old Pliocene volcano) that may be associated with the contact, the substantially stronger seismicity of the WRZ is associated with the major Carbon River—Skate Mountain anticline. This anticline, or uplifted fold, and the narrower width of the northern part of the SWCC, reflects an episode of compression of this formation. Of great interest here is that both the northern lobe of the SWCC and the Carbon River anticline are aligned towards Tiger Mountain (an uplifted block of the Puget Group of sedimentary and volcanic deposits typical of the Puget Lowland) and the adjacent Raging River anticline (see map). The lowest exposed strata of Tiger Mountain, the mid-Eocene marine sediments of the Raging River formation, may be correlative with the SWCC.
https://en.wikipedia.org/wiki?curid=27651043
1,269,029
2,021,077
Grainyhead-like genes are a family of highly conserved transcription factors that are functionally and structurally homologous across a large number of vertebrate and invertebrate species. For an estimated 100 million years or more, this genetic family has been evolving alongside life to fine tune the regulation of epithelial barrier integrity during development, fine-tuning epithelial barrier establishment, maintenance and subsequent homeostasis. The three main orthologues, Grainyhead-like 1, 2 and 3, regulate numerous genetic pathways within different organisms and perform analogous roles between them, ranging from neural tube closure, wound healing, establishment of the craniofacial skeleton and repair of the epithelium. When Grainyhead-like genes are impaired, due to genetic mutations in embryogenesis, it will cause the organism to present with developmental defects that largely affect ectodermal (and sometimes also endodermal) tissues in which they are expressed. These subsequent congenital disorders, including cleft lip and exencephaly, vary greatly in their severity and impact on the quality of life for the affected individual. There is much still to learn about the function of these genes and the more complex roles of Grainyhead-like genes are yet to be discovered.
https://en.wikipedia.org/wiki?curid=63194019
2,019,914
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Founded in 1889 in South Carolina, Clemson University has committed to reducing greenhouse emissions by 20 percent on campus by the year 2020 from 2000 levels as part of their adopted sustainable energy policy in 2008. As part of their plan to further reduce gas emissions, Clemson has adopted a Sustainable Building Policy Plan in 2004 pledging “all new construction and major renovations would achieve at least a Silver LEED certification from the U.S. Green Building Council.” Becoming part of the earliest adopters of this policy, their Advanced Materials Laboratory was the first LEED-certified building in the state. Already resulting in eight more successful projects either certified as LEED-silver or LEED-gold. “Clemson will also pursue opportunities to produce carbon-free energy through three primary approaches: Determine “big-swing” projects to source renewable/clean energy at less than or equal to current prices. Evaluate other sourcing alternatives. Evaluate possible on-site power generation and/or energy storage options including combined Heat 7 Power (CHP), including microturbines; Geothermal heat pump systems (heating & cooling); Bio-fuels; Solar thermal and photovoltaics; and Energy Storage Alternatives (batteries and thermal).”
https://en.wikipedia.org/wiki?curid=33630916
2,125,535
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Collaborative problem solving is about people working together face-to-face or in online workspaces with a focus on solving real world problems. These groups are made up of members that share a common concern, a similar passion, and/or a commitment to their work. Members are willing to ask questions, wonder, and try to understand common issues. They share expertise, experiences, tools, and methods. These groups can be assigned by instructors, or may be student regulated based on the individual student needs. The groups, or group members, may be fluid based on need, or may only occur temporarily to finish an assigned task. They may also be more permanent in nature depending on the needs of the learners. All members of the group must have some input into the decision-making process and have a role in the learning process. Group members are responsible for the thinking, teaching, and monitoring of all members in the group. Group work must be coordinated among its members so that each member makes an equal contribution to the whole work. Group members must identify and build on their individual strengths so that everyone can make a significant contribution to the task. Collaborative groups require joint intellectual efforts between the members and involve social interactions to solve problems together. The knowledge shared during these interactions is acquired during communication, negotiation, and production of materials. Members actively seek information from others by asking questions. The capacity to use questions to acquire new information increases understanding and the ability to solve problems. Collaborative group work has the ability to promote critical thinking skills, problem solving skills, social skills, and self-esteem. By using collaboration and communication, members often learn from one another and construct meaningful knowledge that often leads to better learning outcomes than individual work.
https://en.wikipedia.org/wiki?curid=1467948
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The years immediately following the American Civil War were a difficult time for the academy as it struggled to admit and reintegrate cadets from former Confederate states. The first cadets from Southern states were re-admitted in 1868, and 1870 saw the admission of the first African-American cadet, James Webster Smith of South Carolina. Smith did not graduate, so Henry O. Flipper of Georgia become the first African-American graduate in 1877, graduating 50th of a class of 77. In the 35 years between the Civil War and 1900, the academy admitted 12 African American cadets with three graduating. Despite the low graduation rate, the admittance of African-American cadets at all to West Point was unusual and progressive for the country as a whole during this time. The post Civil War Era also saw a shift in the academy's curriculum from being very focused upon engineering to a more broad education. The control of the academy was changed from the Corps of Engineers to the Secretary of War, and for the first time, Superintendents were not from the Engineer Branch. As the "Gilded Age" saw a blossoming of liberal arts education in the private sector, West Point struggled to adapt and change its engineering-heavy curriculum to match the times. 1875, Willard Young, son of Mormon leader and pioneer, Brigham Young, became the first Latter-day Saint to graduate. Other more notable graduates during this period were George Washington Goethals from the Class of 1880 and John J. Pershing from the Class of 1886. Goethals would gain notoriety as the chief engineer of the Panama Canal and Pershing would become famous for chasing the famed Pancho Villa on the Mexican border and for leading American Forces during World War I. The outbreaks of the Spanish–American War and the Philippine–American War saw the classes of 1899 and 1901 graduate early, the first such classes to do so.
https://en.wikipedia.org/wiki?curid=20793344
1,449,365
1,111,813
A "biopsy" is a small piece of tissue removed primarily for the purposes of surgical pathology analysis, most often in order to render a definitive diagnosis. Types of biopsies include "core biopsies", which are obtained through the use of large-bore needles, sometimes under the guidance of radiological techniques such as ultrasound, CT scan, or magnetic resonance imaging. Core biopsies, which preserve tissue architecture, should not be confused with fine-needle aspiration specimens, which are analyzed using cytopathology techniques. "Incisional biopsies" are obtained through diagnostic surgical procedures that remove part of a suspicious lesion, whereas "excisional biopsies" remove the entire lesion and are similar to therapeutic "surgical resections." Excisional biopsies of skin lesions and gastrointestinal polyps are very common. The pathologist's interpretation of a biopsy is critical to establishing the diagnosis of a benign or malignant tumor, and can differentiate between different types and grades of cancer, as well as determining the activity of specific molecular pathways in the tumor. This information is important for estimating the patient's prognosis and for choosing the best treatment to administer. Biopsies are also used to diagnose diseases other than cancer, including inflammatory, infectious, or idiopathic diseases of the skin and gastrointestinal tract, to name only a few.
https://en.wikipedia.org/wiki?curid=9971598
1,111,247
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This experiment was designed to map the sources of X-ray emission in the sky in the 0.5 - 15-A region. The detector, mounted on the side of the spacecraft, was a large-area proportional counter mounted to point radially outward from the spin axis, which pointed continually toward the sun. The detector window was made of 1/8-mil-thick mylar with an effective area of 100-cm. The gas filler was a mixture of 0.45 argon, 0.45 xenon, and 0.10 carbon dioxide maintained at 4 lb/cm. A collimator limited the field of view to 8°, full width at half maximum (FWHM) in a plane containing the spin axis and 1° in the plane perpendicular to the spin axis. Charged particle information was provided by proportional counters mounted on three sides of the X-ray detector. Aspect information was provided by a blue-sensitive photomultiplier capable of detecting all fourth-magnitude and not fifth-magnitude stars. The resolution of the aspect system and the accuracy with which the experiment could locate X-ray sources was better than ± 0.25°. The detector was connected to a 400-channel pulse time analyzer which was synchronized with the spin period to give a 2° spatial resolution in the spin direction. The whole celestial sphere was surveyed every 6 months. Due to the low altitude of the satellite, there was a high charged-particle count at all times. This background limited the usefulness of the data, and no results from this experiment were published.
https://en.wikipedia.org/wiki?curid=57721944
2,069,640
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The single most important clinical advance over the past 15 years has been the application of BNCT to treat patients with recurrent tumors of the head and neck region who had failed all other therapy. These studies were first initiated by Kato et al. in Japan. and subsequently followed by several other Japanese groups and by Kankaanranta, Joensuu, Auterinen, Koivunoro and their co-workers in Finland. All of these studies employed BPA as the boron delivery agent, usually alone but occasionally in combination with BSH. A very heterogeneous group of patients with a variety of histopathologic types of tumors have been treated, the largest number of which had recurrent squamous cell carcinomas. Kato et al. have reported on a series of 26 patients with far-advanced cancer for whom there were no further treatment options. Either BPA + BSH or BPA alone were administered by a 1 or 2 h i.v. infusion, and this was followed by BNCT using an epithermal beam. In this series, there were complete regressions in 12 cases, 10 partial regressions, and progression in 3 cases. The MST was 13.6 months, and the 6-year survival was 24%. Significant treatment related complications ("adverse" events) included transient mucositis, alopecia and, rarely, brain necrosis and osteomyelitis.
https://en.wikipedia.org/wiki?curid=32637211
1,055,994
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Not all isolated populations will show evidence of genetic drift. Genetic homogeneity can be attributed to one of two explanations, both of which indicate that natal philopatry is not absolute within a species. Firstly, a lack of divergence may be due to founder effects, which explains how individuals that start new populations carry the genes of their source population. If only a short (in evolutionary timescales) period of time has passed, insufficient divergence may have occurred. For example, study of mitochondrial DNA microsatellites found no significant difference between colonies of black-browed albatross ("T. melanophrys") on the Falkland Islands and Campbell Island, despite the sites being thousands of kilometres apart. Observational evidence of white-capped albatross ("T. [cauta] steadi") making attempts to build nests on a south Atlantic Island, where the species had never been previously recorded, demonstrate that range extension by roaming sub-adult birds is possible. Secondly, there may be sufficient gene exchange as to prevent divergence. For example, isolated (yet geographically close) populations of the Buller’s albatross ("T. bulleri bulleri") have been shown to be genetically similar. This evidence has only recently, for the first time, been supported by mark-recapture data, which showed one bird marked on one of the two breeding islands was nesting on the other island.
https://en.wikipedia.org/wiki?curid=2988185
1,207,418
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"B. affinis" requires three different types of habitats (each for foraging, nesting, and hibernating) which are geographically close to one another, making this species particularly vulnerable to extinction. It requires a temperate climate, and can even withstand cold temperatures that most species of bumblebees cannot. In addition, "B. affinis" has been found at elevations as high as 1600 m. "B. affinis" is known to visit a number of sites for foraging, including sand dunes, farmland, marshes, and wooded areas. Members actively forage between April and October, thus requiring flowers to bloom for a long period of time. "B. affinis" nests are strikingly similar to other species of bees, which makes them difficult to locate. However, queen and workers work together to make individual cells and honey pots out of wax stores. In terms of their hibernating habitat, little information is known. "B. affinis" queens overwinter, but they most likely will live underground or burrow into rotting logs during the winter to survive. While "B. affinis" habitat used to be highly prevalent, a large decline has occurred in recent years, possibly due to increased land development and agricultural use.
https://en.wikipedia.org/wiki?curid=40570605
1,451,257
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Before graduating from high school in June 1941, Ovshinsky worked as a teacher, tool maker and machinist in various local shops affiliated with the rubber industry. During the Second World War, he and his bride, Norma Rifkin, moved to Arizona, where Ovshinsky worked for a time in the tool room of a Goodyear plant in Litchfield, not far from Phoenix. Returning to Akron shortly before the end of the war, Ovshinsky eventually established his own machine company, Stanford Roberts, initially in a barn. There he developed and patented his first invention, the Benjamin Center Drive, named after his father. This unique automatic high-speed center drive lathe had many important uses. After Ovshinsky sold his company to the New Britain Machine Company in Connecticut, it was used to help solve the national crisis of making artillery shells in large enough volume for wartime needs during the Korean War. Meanwhile, Ovshinsky continued to develop his growing interest in human and machine intelligence, avidly studying the research literature on neurophysiology, neurological disease, and cybernetics, corresponding briefly with Norbert Wiener.
https://en.wikipedia.org/wiki?curid=2785878
1,275,526
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The exponential growth of the city during the industrial revolution of the 19th century, in addition to the efforts of the then President of Peru Manuel Pardo to improve the city's architecture and urban planning during the 1870s, forced the university to move to a new campus adjacent to the former Jesuit monastery where the Royal Convictory of San Carlos resided —currently this is called the “Casona of the University Park” or simply the “Casona of San Marcos”—. In those years, San Marcos was already considered the tutelary nucleus of scientific and cultural institutions during the Viceroyalty and the nascent Republic; To this was added the fact that its professors, graduates and even students were part of missions that created various Hispanic American universities. In 1878, during the government of Manuel Pardo, the General Regulation of Public Instruction was issued, instituting the concept of major and minor universities, the first title corresponding to San Marcos and the second to the universities of Arequipa and Cusco. During the War of the Pacific and specifically during the occupation of Lima by Chilean troops, art and cultural objects and assets were taken from the university in order to be taken to Chile by sea. At the end of the 19th century, the “San Fernando” Faculty of Medicine, which was located in a building in the old Plaza de Santa Ana —today Plaza Italia—, moved to its current location in the Orchard of Mestas, that of the historic premises on , Barrios Altos in the historic center of Lima. Once the war ended, by law of 1901 it is stated that Peruvian university education corresponds to the National University of San Marcos and the minor universities of Trujillo, Cusco and Arequipa, which were later joined by the Catholic University of Lima and technical schools.
https://en.wikipedia.org/wiki?curid=1070670
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The DASS engine is a pre-cooled combined cycle propulsion concept that can produce thrust over a wide range of vehicle flight Mach numbers (rest to hypersonic). Derivatives of the engine can be used for propulsion of an SSTO vehicle, long-range missiles, and hypersonic transport aircraft. The engine is being developed with the flexibility for various vehicles and mission profiles. The concept uses existing aerospace technologies, including conventional gas turbine components, and new developments in nanotechnology to overcome some of the key technical obstacles associated with overheating and fuel storage. In high-speed flight, the incoming air has a very high dynamic pressure and aerodynamic deceleration results in a rise in static pressure and temperature. Temperatures can rise above the material limits of the compressor blades in a conventional turbojet. A strategy to alleviate this problem is to place a heat exchanger downstream of the inlet in order to reduce gas temperatures prior to mechanical compression. Similar to the deep-cooled turbojet or the liquefied air cycle engine (LACE), energy extracted from the incoming air in the DASS engine is added back into the system downstream as sensible heat in the fuel stream.
https://en.wikipedia.org/wiki?curid=43208165
1,976,760
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Homeostatic plasticity manages synaptic connections across the entire cell in an attempt to keep them at manageable connection levels. Hebbian methods tend to drive networks into either a maximized state or a minimized state of firing, thus limiting the potential activity and growth of the network. With homeostatic mechanisms in place there is now a sort of "gain control" which allows these Hebbian methods to be checked in order to maintain their information processing abilities. This kind of modulation is important to combat intense lack of neural activity, such as prolonged sensory deprivation (in this study in particular it is light-deprivation affecting visual cortex neurons) or damage caused by stroke. Synaptic scaling is a mechanism in place to hold synapse sensitivity at normalized levels. Prolonged periods of inactivity increase the sensitivity of the synapses so that their overall activity level can remain useful. Chronic activity causes desensitization of the receptors, lowering overall activity to a more biologically manageable level. Both AMPA and NMDA receptor levels are affected by this process and so the overall "weight" of each synaptic connection (refined by Hebbian methods) is maintained while still increasing the overall level of activity over the entire neuron. It has been shown that both the presynaptic and the postsynaptic neuron are involved in the process, changing the vesicle turnover rate and AMPA receptor composition respectively.
https://en.wikipedia.org/wiki?curid=5064345
1,626,132
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Meanwhile, there were two lines of research into nuclear reactor technology, with Harold Urey continuing research into heavy water at Columbia, while Arthur Compton brought the scientists working under his supervision from Columbia, California and Princeton University to join his team at the University of Chicago, where he organized the Metallurgical Laboratory in early 1942 to study plutonium and reactors using graphite as a neutron moderator. Briggs, Compton, Lawrence, Murphree, and Urey met on 23 May 1942, to finalize the S-1 Committee recommendations, which called for all five technologies to be pursued. This was approved by Bush, Conant, and Brigadier General Wilhelm D. Styer, the chief of staff of Major General Brehon B. Somervell's Services of Supply, who had been designated the Army's representative on nuclear matters. Bush and Conant then took the recommendation to the Top Policy Group with a budget proposal for $54 million for construction by the United States Army Corps of Engineers, $31 million for research and development by OSRD and $5 million for contingencies in fiscal year 1943. The Top Policy Group in turn sent it on 17 June 1942, to the President, who approved it by writing "OK FDR" on the document.
https://en.wikipedia.org/wiki?curid=19603
10,011
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Interdisciplinarity was a defining feature of the department that drew expertise from diverse intellectual and scientific sources. Its mission to conduct interdisciplinary and integrative developmental science to understand the growing person in a changing world was carried out in three interrelated core areas - Law and Human Development, Health and Well-being, and Cognition in Context - that were problem-centered and organized around real-world issues. Some of its signal contributions – such as the creation of Head Start or the launch of the child-witness field – were the result of research syntheses across many of the social sciences as well as medicine, nutrition, and law. The department also placed a great emphasis from the very beginning on the public interests and applied values of research findings, which has motivated evidence-based translational research in modern times. The department promoted and celebrated diversity and inclusion, with one-third of its faculty being ethnic minorities and half of the faculty being women during its final years.
https://en.wikipedia.org/wiki?curid=69668821
2,020,189
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The Woods Hole Oceanographic Institution employs a vehicle called the Sentry, which is designed to map the ocean floor at depths of six thousand meters. The vehicle is shaped to minimize water resistance during dives, and utilized acoustic communications systems to report the vehicles status while operating. Unmanned underwater vehicles are capable of recording conditions and terrain below sea ice, as the risk of sending an unmanned vehicle into unstable ice formations is much lower than that of a manned vessel. Glider type unmanned vehicles are often used to measure ocean temperatures and current strengths at various depths. Their simplicity and reduced operating costs allow more UUVs to be deployed with greater frequency, increasing the accuracy and detail of ocean weather reporting. Many UUVs designed with the purpose of collecting seafloor samples or images are of the towed type, being pulled by a ship's cable along either the seafloor or above. Towed vehicles may be selected for tasks which require large amounts of power and data transmission, such as sample testing and high definition imaging, as their tow cable serve as the method of communication between controller and craft.
https://en.wikipedia.org/wiki?curid=4778319
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In late 1969 Elliot Berman joined Exxon's task force which was looking for projects 30 years in the future and in April 1973 he founded Solar Power Corporation (SPC), a wholly owned subsidiary of Exxon at that time. The group had concluded that electrical power would be much more expensive by 2000, and felt that this increase in price would make alternative energy sources more attractive. He conducted a market study and concluded that a price per watt of about $20/watt would create significant demand. The team eliminated the steps of polishing the wafers and coating them with an anti-reflective layer, relying on the rough-sawn wafer surface. The team also replaced the expensive materials and hand wiring used in space applications with a printed circuit board on the back, acrylic plastic on the front, and silicone glue between the two, "potting" the cells. Solar cells could be made using cast-off material from the electronics market. By 1973 they announced a product, and SPC convinced Tideland Signal to use its panels to power navigational buoys, initially for the U.S. Coast Guard.
https://en.wikipedia.org/wiki?curid=2352910
337,888
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Progress during the war was rapid and of great importance, probably one of the decisive factors for the victory of the Allies. A key development was the magnetron in the UK, which allowed the creation of relatively small systems with sub-meter resolution. By the end of hostilities, Britain, Germany, the United States, the USSR, and Japan had a wide variety of land- and sea-based radars as well as small airborne systems. After the war, radar use was widened to numerous fields including: civil aviation, marine navigation, radar guns for police, meteorology and even medicine. Key developments in the post-war period include the travelling wave tube as a way to produce large quantities of coherent microwaves, the development of signal delay systems that led to phased array radars, and ever-increasing frequencies that allow higher resolutions. Increases in signal processing capability due to the introduction of solid state computers has also had a large impact on radar use.
https://en.wikipedia.org/wiki?curid=1280053
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Novaro et al. (2000) assessed the potential ecological extinction of guanacos ("Lama guanicoe") and lesser rheas ("Pterocnemia pennata") as a prey source for native omnivores and predators in the Argentine Patagonia. These native species are being replaced by introduced species such as the European rabbit, red deer, and domestic cattle; the cumulative damage from the increased herbivory by introduced species has also served to accelerate destruction of the already dwindling Argentine pampas and steppe habitats. This was the first study to take into account a large number of diverse predators, ranging from skunks to pumas, as well as conduct their survey in non-protected areas that represent the majority of southern South America. Novaro and his colleagues found that the entire assemblage of native carnivores relied primarily on introduced species as a prey base. They also suggested that the lesser rhea and guanaco had already passed their ecological effective density as a prey species, and thus were ecological extinct. It is possible that the niches of introduced species as herbivores too closely mirrored those of the natives, and thus competition was the primary cause of ecological extinction. The effect of introduction of new competitors, such as the red deer and rabbit, also served to alter the vegetation in the habitat, which could have further pronounced the intensity of competition. Guanacos and rheas have been classified as a low risk for global extinction, but this simplistic view of their demography doesn't take into account that they have already become functionally extinct in the Argentine Patagonia. Novaro and his colleagues suggest "this loss could have strong effects on plant-animal interactions, nutrient dynamics, and disturbance regimes ..." This is a prime example of how current conservation policy has already failed to protect the intended species because of its lack of a functionally sound definition for extinction.
https://en.wikipedia.org/wiki?curid=11409359
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begins in 2029, and features Section 9, led by Chief Daisuke Aramaki and Major Motoko Kusanagi, as they investigate the Puppeteer, a cyber-criminal wanted for committing a large number of crimes by proxy through "ghost hacking" humans with cyberbrains. As the investigation continues, Section 9 discovers that the Puppet Master is actually an advanced artificial intelligence created by a department of the Japanese government, taking up residence in a robot body. After destroying the latest host of the Puppeteer, Section 9 believes all is well, until the Major discovers the Puppet Master in her own mind. After hearing the Puppeteer's wishes to reach its next step in evolution, Kusanagi allows it to become one with her own ghost. After this event, the Major leaves Section 9 to work as a private contractor, with the remaining members of the unit, Batou, Togusa, Ishikawa, Saito, Paz, Borma and Azuma, continuing their work as covert operatives, occasionally meeting up with the Major in her various guises. These stories were later collected under the name . In 2035, the Major, now known as Motoko Aramaki, works as a security expert for Poseidon Industrial, now an entity composed of multiple identities that she controls via the network in other prosthetic bodies that attack industrial spies, assassins, and cyber-hackers, solving various crimes, while still at her day job. However, a psychic investigator finds something dangerous emerging as the teachings of a professor of artificial intelligence fall into the wrong hands and attempt to intermingle with the Major's current evolving sense of self. These stories are collected under the title .
https://en.wikipedia.org/wiki?curid=3271673
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Reintroduction biology is a relatively young discipline and continues to be a work in progress. No strict and accepted definition of reintroduction success exists, but it has been proposed that the criteria widely used to assess the conservation status of endangered taxa, such as the IUCN Red List criteria, should be used to assess reintroduction success. Successful reintroduction programs should yield viable and self-sustainable populations in the long-term. The IUCN/SSC Re-introduction Specialist Group & Environment Agency, in their 2011 Global Re-introduction Perspectives, compiled reintroduction case studies from around the world. 184 case studies were reported on a range of species which included invertebrates, fish, amphibians, reptiles, birds, mammals, and plants. Assessments from all of the studies included goals, success indicators, project summary, major difficulties faced, major lessons learned, and success of project with reasons for success or failure. A similar assessment focused solely on plants found high rates of success for rare species reintroductions. An analysis of data from the Center for Plant Conservation International Reintroduction Registry found that, for the 49 cases where data were available, 92% of the reintroduced plant populations survived two years.
https://en.wikipedia.org/wiki?curid=477117
417,116
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PfSPZ vaccines are cryopreserved and stored in LNVP freezers below -150 °C and distributed using dry vapor cryoshippers that also maintain temperature below -150 °C. Cryoshippers are self-contained mobile storage units that have hold times of ~14 to 28 days or more depending on model and packaging and are highly suited for last-mile transportation, particularly in Africa. Cryoshippers are used extensively in the livestock breeding, CAR-T and cellular therapies industries. LNVP distribution uses a simple hub-and-spoke model and cryoshippers stay at the immunization sites as temporary storage units that may be recharged with LN2. Advantages of the LNVP cold chain are a) independence from electricity, b) no requirement for fridges, freezers or refrigerated transport, c) no narrow temperature requirements, d) reduced chances for temperature deviations, e) no moving parts, and f) energy efficiency. LN2 is widely available, including in African countries, making LNVP distribution easier than the 2-8 °C and the dry ice and ultralow freezer-based cold chains of Ervebo (vs ebola) and certain SARS-CoV-2 vaccines. Modeling LNVP distribution also indicated costs would be no different per 3-dose regimen than the 2-8 °C cold chain for lyophilized vaccines.
https://en.wikipedia.org/wiki?curid=43793051
1,806,472
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There are two nearly complete braincases known from "Kentrosaurus" though they exhibit some taphonomic distortion. The frontals and parietals are flat and broad, with the latter bearing two transversely concave ventral sides with a ridge running down the middle that divides them. The lateral surface of the frontals form part of the orbit (eye socket) and the medial side creates the anterior part of the endocranial cavity (braincase). Basioccipitals (where the skull articulated with the cervical vertebrae) form the posterior floor of the brain and the occipital condyle, which is large and spherical in "Kentrosaurus". The rest of the braincase is formed by the presphenoid composing the anterior end. The overall braincase morphology is very similar to those of "Tuojiangosaurus", "Huayangosaurus", and "Stegosaurus". However, the occipital condyle is a closer distance to the basisphenoid tubera (bone at the front of the braincase) in "Kentrosaurus" and "Huayangosaurus" than in "Tuojiangosaurus" and some specimens of "Stegosaurus". Due to dinosaurs having more molding in their braincases, endocasts of "Kentrosaurus" can be reconstructed using the preserved fossils. The brain is relatively short, deep, and small, with a strong cerebral and pontine flexures and a steeply inclined posterodorsal edge when compared to those of other ornithischians. There is a small dorsal projection in the endocast where an unossified (lacking bone) region between the top of the supraoccipital (bone at the top-back of the braincase) and overlying parietal that was likely covered in cartilage. This characteristic is seen in other ornithischians. Because of the prominent flexures, many of the aspects of the brain can only be interpreted by the present structures.
https://en.wikipedia.org/wiki?curid=1005294
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Studies show that the causes of heart disease differ greatly between humans and chimpanzees. In this study, the scientists provided some new data and summarized existing reports on the subject. They also allow other primitives to have limited data, suggesting that they are more like chimpanzees in this respect. In general, the result is that heart disease does not represent a similarity between humans and other hominids, but rather an inexplicably special difference. Finally, the preliminary evidence of differences in extracellular matrix and glycosylation patterns between human and human-like hearts are proved and provided, which may be related to the understanding of these differences. Heart disease was the cause of 16 of the 52 deaths at Yakex primate research center between 1992 and 2005, and cardiac biopsies were carefully examined. This includes 9 animals (8 males, (1) dying females, (3) looking at the animals' serious animals (2 males, females). Almost all of these pathological abnormalities of death are associated with this type of FMI. Chimpanzees are very similar. An example shows a chimpanzee which goes through the heart muscle without hemiplegia, and heaven goes directly around the blood vessels, which can be seen in some people's hearts. For other reasons, the death of the Yerkes center also indicates that myocardial fibrosis was severe during this period of 14 men and 4 women, autopsies were fragmented by the IMF.
https://en.wikipedia.org/wiki?curid=60770250
2,052,306
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Franklin decided to study science because she went to school during a time when the teaching of history was censored. "I remember a real subversive pleasure," she told an interviewer many years later, "that there was no word of authority that could change either the laws of physics or the conduct of mathematics." In 1948, Franklin received her PhD in experimental physics at the Technical University of Berlin. She began to look for opportunities to leave Germany after realizing there was no place there for someone fundamentally opposed to militarism and oppression. Franklin moved to Canada after being offered the Lady Davis postdoctoral fellowship at the University of Toronto in 1949. She then worked for 15 years (from 1952 to 1967) as first a research fellow and then as a senior research scientist at the Ontario Research Foundation. In 1967, Franklin became a researcher and associate professor at the Department of Metallurgy and Materials Science University of Toronto's Faculty of Engineering where she was an expert in metallurgy and materials science. She was promoted to full professor in 1973 and was given the designation of University Professor in 1984, becoming the first female professor to receive the university's highest honour. She was appointed professor emerita in 1987, a title she retained until her death. She served as director of the university's Museum Studies Program from 1987 to 1989, was named a Fellow of the Ontario Institute for Studies in Education in 1988, and a Senior Fellow of Massey College in 1989.
https://en.wikipedia.org/wiki?curid=1094203
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In November 1961, Eva Hesse married fellow sculptor Tom Doyle. In August 1962, Eva Hesse and Tom Doyle participated in an Allan Kaprow Happening at the Art Students League of New York in Woodstock, New York. There Hesse made her first three-dimensional piece: a costume for the Happening. In 1963, Eva Hesse had a one-person show of works on paper at the Allan Stone Gallery on New York's Upper East Side. By 1965 the two had moved to Germany so that Doyle could pursue an artist's residency from German industrialist and collector Friedrich Arnhard Scheidt, a move Hesse was not happy about. Hesse and Doyle, whose marriage was by then falling apart, lived and worked in an abandoned textile mill in Kettwig-on-the-Ruhr near Essen for about a year.. The building still contained machine parts, tools, and materials from its previous use and the angular forms of these disused machines and tools served as inspiration for Hesse’s mechanical drawings and paintings. Her first sculpture was a relief titled" Ringaround Arosie", which featured cloth-covered cord, electrical wire, and masonite. This year in Germany marked a turning point in Hesse's career. From here on she would continue to make sculptures, which became the primary focus of her work. Returning to New York City in 1965, she began working and experimenting with the unconventional materials that would become characteristic of her ouptut: latex, fiberglass, and plastic.
https://en.wikipedia.org/wiki?curid=2508428
831,807
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St. Martin's Engineering college (UGC Autonomous) is promoted and managed under St. Martin's Children's Educational Society (SMCES) that was established in the year 1982. It was started with a school having student strength of 42. As of today, the society has wide spread into four branches from where more than 7,000 students receive education. St. Martin's Engineering College (SMEC), Secunderabad was established in the year 2002. Currently the student's intake is 1020 with 6 UG programs and 1 PG programs. Total students strength is more than 4000. St. Martin's Engineering College (SMEC) is the only college in Telangana to receive NAAC(A+). Only young college in Telangana to receive UGC-Paramarsh. SMEC situated in an eco-friendly environment, the college has the best infrastructure. engineering programs are NBA accredited, ISO certified, DSIR Recognition, Remote center of IIT Bombay, Member of CII and MSME certified Institution. Signed more than 78 MoUs with major companies’ and institutions. Careers 360 Certified as AA+; Competition Success Review Ranked 3 out of 20; Career Connect Ranked 13 ‘Best Engineering Colleges of India and Wikipedia Ranked 8th in Telangana. The college is bestowed with the glorious Governor Award twice; The Engineering Educators' Award 2019; NIRDPR Award (Govt. of India); IDF Best Partner Award; Dewang Mehta Award; TCS ION Award; CSI Award (Students Chapter); Best Innovation by Federation of Gujarat Industries and Street Cause-Most Dedicated Division. Best college award from education Matter and Best Sports College by Stumagz, Telangana, Award from Street Cause, National Leadership Excellence Award- 2019 by ICCI. Rs.21.46 Lakhs received from SERB, Government of India, Consultancy project worth of Rs.444 Crores received from GHMC – Hyderabad, Government of Telangana. Recently Rs.5 lakhs funding from AICTE also received. The faculty members of the college have published 24 books and 40 patents are published by the faculty members. The crowning glory in academic excellence was achieved by bagging gold medals from University every year. 138 innovative products are developed by students and faculties.
https://en.wikipedia.org/wiki?curid=23990873
1,673,368
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In addition to the field geology training, Young and Duke also trained to use their EVA space suits, adapt to the reduced lunar gravity, collect samples, and drive the Lunar Roving Vehicle. The fact that they had been backups for Apollo 13, planned to be a landing mission, meant that they could spend about 40 percent of their time training for their surface operations. They also received survival training and prepared for technical aspects of the mission. The astronauts spent much time studying the lunar samples brought back by earlier missions, learning about the instruments to be carried on the mission, and hearing what the principal investigators in charge of those instruments expected to learn from Apollo 16. This training helped Young and Duke, while on the Moon, quickly realize that the expected volcanic rocks were not there, even though the geologists in Mission Control initially did not believe them. Much of the training—according to Young, 350 hours—was conducted with the crew wearing space suits, something that Young deemed vital, allowing the astronauts to know the limitations of the equipment in doing their assigned tasks. Mattingly also received training in recognizing geological features from orbit by flying over the field areas in an airplane, and trained to operate the Scientific Instrument Module from lunar orbit.
https://en.wikipedia.org/wiki?curid=1970
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Due to a strong human presence and impact, sustainable landscape architecture is more important now than it has ever been. Tools within the built environment, such as natural filters, climate control tactics and reconciliation ecology are recommended to sustain the planet. This requires a combination of both Eastern and Western cultural drivers. In Southern Europe, domestic species are being re-introduced to urbanized areas to help with cultural identity, food production, and a lack of vegetation in the city. Athens is an example of this tactic. In the 1980s, Athens, Greece was a compact city. It slowly began to spread out into periphery farming land, consuming the landscapes bordering the urban space. The government has begun to plant olive trees in such areas, therefore benefitting from small green urban spaces in several categories. Olive trees offer cultural and traditional sustainability, due to their importance in Greek culture and history. They offer local food production and a source of income. Furthermore, the trees increase shade in heat island, and decrease the risk of fire. They are a low-maintenance crop which emphasizes sustainable landscape design within multiple realms, making their implementation a favorable way to design challenging urban landscapes in a sustainable fashion. The emphasis on the cultural identity of the olive trees ensures cultural sustainability, the suggested fourth pillar in sustainable development.
https://en.wikipedia.org/wiki?curid=5285068
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Nearly all adult tunicates are suspension feeders (the larval form usually does not feed), capturing planktonic particles by filtering sea water through their bodies. Ascidians are typical in their digestive processes, but other tunicates have similar systems. Water is drawn into the body through the buccal siphon by the action of cilia lining the gill slits. To obtain enough food, an average ascidian needs to process one body-volume of water per second. This is drawn through a net lining the pharynx which is being continuously secreted by the endostyle. The net is made of sticky mucus threads with holes about 0.5 µm in diameter which can trap planktonic particles including bacteria. The net is rolled up on the dorsal side of the pharynx, and it and the trapped particles are drawn into the esophagus. The gut is U-shaped and also ciliated to move the contents along. The stomach is an enlarged region at the lowest part of the U-bend. Here, digestive enzymes are secreted and a pyloric gland adds further secretions. After digestion, the food is moved on through the intestine, where absorption takes place, and the rectum, where undigested remains are formed into faecal pellets or strings. The anus opens into the dorsal or cloacal part of the peribranchial cavity near the atrial siphon. Here, the faeces are caught up by the constant stream of water which carries the waste to the exterior. The animal orientates itself to the current in such a way that the buccal siphon is always upstream and does not draw in contaminated water.
https://en.wikipedia.org/wiki?curid=378598
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Prior to the cognitive revolution, behaviorism was the dominant trend in psychology in the United States. Behaviorists were interested in "learning," which was seen as "the novel association of stimuli with responses." Animal experiments played a significant role in behaviorist research, and prominent behaviorist J. B. Watson, interested in describing the responses of humans and animals as one group, stated that there was no need to distinguish between the two. Watson hoped to learn to predict and control behavior through his research. The popular Hull-Spence stimulus-response approach was, according to George Mandler, impossible to use to research topics that held the interest of cognitive scientists, like memory and thought, because both the stimulus and the response were thought of as completely physical events. Behaviorists typically did not research these subjects. B. F. Skinner, a functionalist behaviorist, criticized certain mental concepts like instinct as "explanatory fiction(s)," ideas that assume more than humans actually know about a mental concept. Various types of behaviorists had different views on the exact role (if any) that consciousness and cognition played in behavior. Although behaviorism was popular in the United States, Europe was not particularly influenced by it, and research on cognition could easily be found in Europe during this time.
https://en.wikipedia.org/wiki?curid=2210064
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Ancient Greek mathematicians are known to have solved specific instances of polynomial equations with the use of straightedge and compass constructions, which simultaneously gave a geometric proof of the solution's correctness. Once a construction was completed, the answer could be found by measuring the length of a certain line segment (or possibly some other quantity). A quantity multiplied by itself, such as formula_1 for example, would often be constructed as a literal square with sides of length formula_2 which is why the second power "formula_3" is referred to as "formula_4 squared" in ordinary spoken language. Thus problems that would today be considered "algebra problems" were also solved by ancient Greek mathematicians, although not in full generality. A guide to systematically solving low-order polynomials equations for an unknown quantity (instead of just specific instances of such problems) would not appear until "The Compendious Book on Calculation by Completion and Balancing" by Muhammad ibn Musa al-Khwarizmi, who used Greek geometry to "prove the correctness" of the solutions that were given in the treatise. However, this treatise was entirely rhetorical (meaning that everything, including numbers, was written using words structured in ordinary sentences) and did not have any "algebraic symbols" that are today associated with algebra problems – not even the syncopated algebra that appeared in "Arithmetica"
https://en.wikipedia.org/wiki?curid=16266307
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Molecular mechanisms produce specialized metabolites in various ways. Biosynthetic Gene Clusters (BGCs) attract attention, since several metabolites are clinically valuable, anti-microbial, anti-fungal, anti-parasitic, anti-tumor and immunosuppressive agents produced by the modular action of multi-enzymatic, multi-domains gene clusters, such as Nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). Diverse studies show that grouping BGCs that share homologous core genes into gene cluster families (GCFs) can yield useful insights into the chemical diversity of the analyzed strains, and can support linking BGCs to their secondary metabolites. GCFs have been used as functional markers in human health studies and to study the ability of soil to suppress fungal pathogens. Given their direct relationship to catalytic enzymes, and compounds produced from their encoded pathways, BGCs/GCFs can serve as a proxy to explore the chemical space of microbial secondary metabolism. Cataloging GCFs in sequenced microbial genomes yields an overview of the existing chemical diversity and offers insights into future priorities. Tools such as BiG-SLiCE and BIG-MAP have emerged with the sole purpose of unveiling the importance of BGCs in natural environments.
https://en.wikipedia.org/wiki?curid=53970843
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In a typical undergraduate program for physics majors, required courses are in the sub-disciplines of physics, with additional required courses in mathematics. Because much of the insight of physics is described by differential equations relating matter, space, and time (for example Newton's law of motion and the Maxwell equations of electromagnetism), students have to be familiar with differential equations. In a typical undergraduate program for chemistry majors, emphasis is placed on laboratory classes and understanding and applying models describing chemical bonds and molecular structure. Emphasis is also placed in the methods for analysis and the formulas and equations used when considering the chemical transformation. Students take courses in math, physics, chemistry, and often biochemistry. Between the two programs of study, there is a large area of overlap (calculus, introductory physics, quantum mechanics, thermodynamics). However, physics places a larger emphasis on fundamental theory (with its deep mathematical treatment) while chemistry places more emphasis in combining the most important mathematical definitions of the theory with the approach of the molecular models. Laboratory skills may differ in both programs, as students may be involved in different technologies, depending on the program and the institution of higher education (for example, a chemistry student may spend more laboratory time dealing with glassware for distillation and purification or on a form of chromatography-spectroscopy instrument, while a physics student may spend much more time dealing with a laser and non-linear optics technology or some complex electrical circuit).
https://en.wikipedia.org/wiki?curid=33615960
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PT-DBCL is by far the most common form of testicular cancer in men >60 years of age. It usually develops in this age group (median age ~65 years old, range 10–96 years) and presents as a painless testicular mass or swelling in one testis or, in ~6% of cases, both testes: PT-DLBCL is the most common testicular cancer to present with disease in both testicles. About 30-40% of afflicted individuals present concurrently with hydrocele testis, i.e. an enlarged testis due to the accumulation of clear fluid. The tumors commonly increase in size at a rapid pace, may advance locally to involve the epididymis, spermatic cord, scrotal skin, and/or regional lymph nodes, and may cause sharp scrotal pain. About 10% to 33% of individuals have B symptoms such as fever, night sweats, and weight loss. Initial laboratory studies show increases in serum lactate dehydrogenase levels in a third of cases. Some 80% of individuals present with either localized Ann Arbor stage I or locally advanced Ann Arbor stage II disease. The remaining ~20% of cases have disseminated Ann Arbor stage III or IV disease that has spread to the abdominal lymph nodes, Waldeyr's ring of lymphoid tissue that surrounds the nasopharynx and oropharynx, contralateral testis, skin, lung, and, most seriously, the parenchyma of and/or the leptomembranes surrounding either the brain or spinal cord.
https://en.wikipedia.org/wiki?curid=63040871
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The story was well praised. Nick Plessas of "Electronic Gaming Monthly" ("EGM") said the story's most memorable moments were the interactions between Kratos and Atreus. He also noted, "there is often some comic relief to be found when Kratos's curtness and Atreus' charming naivety collide." He felt the presence of Atreus showed a side to Kratos not seen before, and that Kratos had evolved emotionally: "The rage and pain of his past is in constant conflict with his desire to spare his son from it, which comes across in even the most subtle actions and words, demonstrating the effort he is putting in." Plessas said Atreus' character was similarly complex. He commented it is easy for child characters "to succumb to a number of annoying child archetypes," but Atreus is more like a young man who is doing his best in an adult world. "Game Informer"s Joe Juba similarly praised the story, particularly the relationship between Kratos and Atreus: "The interactions of Kratos and Atreus range from adversarial to compassionate, and these exchanges have ample room to breathe and draw players in." Juba said that Kratos conveys more character than in any previous game. Peter Brown of "GameSpot" felt that although Kratos and Atreus were enjoyable, it was Mímir who stole the show. He also said that regardless of which character the player meets, the cast of "God of War" is "strong, convincing, and oddly enchanting." Writing for "Game Revolution", Jason Faulkner praised Santa Monica for creating a sequel that new players would be able to understand without having played any of the previous games, while at the same time providing story references to those past games that returning fans would appreciate. Speaking of the relationship between Kratos and Atreus, Faulkner wrote that, "Watching the two grow throughout their journey is incredibly rewarding," equating it to that of Ellie and Joel from "The Last of Us" or Lee and Clementine from Telltale Games' "The Walking Dead".
https://en.wikipedia.org/wiki?curid=50810460
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Treatment for femoral dysfunction comes in several ways depending on the symptoms of the patient. This includes dealing with the underlying causes, lifestyle remedies, medications, physical therapy and surgery. In order to relieve minor symptoms, patients are to deal with the underlying cause and make changes to their lifestyles. For example, if compression on the nerve is the underlying cause, it is important to avoid tight clothing, or activities that can put pressure on the femoral nerve for a long period of time in order to relieve the compression. If diabetes is the underlying condition, patients will need to lose weight or find ways to bring their blood sugar back to normal. However, if the condition still persists, treatments such as medication and physical therapy is required. In addition to the corticosteroids injection in the leg to reduce inflammation, pain medications are prescribed to alleviate pain. For such neuropathic pains, the most common prescriptions are gabapentin, pregabalin, or amitriptyline. Physical therapy on the other hand, not only helps to build strength in leg muscles, but also helps to reduce pain and promote mobility. Rehabilitation will be focused on areas such as hip abduction, hip rotation and kneeling hip flexor stretch. Moreover, orthopaedic devices may also be given to patients to assist with mobilization. If conservative treatments above still lead to unsuccessful treatment outcomes, surgery, which is more invasive, is the last resort. However, up till now, surgery for femoral neuropathy poses a tough challenge because there have been no cases of complete functional recovery despite the microsurgical equipment development.
https://en.wikipedia.org/wiki?curid=67272105
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Perhaps his most significant engineering failure, as noted by division chief Yuri Demyanko, was his insistence that hydrogen fuel was unsuitable for use as a rocket fuel. As a result, the Soviet space program was still discussing the use of hydrogen-fueled engines while the Americans were assembling the Saturn V launcher. Also, Glushko's design bureau consistently failed at building a rocket engine powered by LOX/Kerosene with a large combustion chamber to rival the American F-1 used on the Saturn V; instead, his solution was the RD-270, a single large combustion-chamber engine powered by hypergolic propellants which had almost the same thrust and better specific impulse when compared to the F-1 engine. In addition, the RD-270 used the very advanced full-flow, staged, closed-cycle combustion concept as opposed to the simple open-cycle gas generator design used by the F-1 rocket engine. This was a primary reason for the failure of the N-1, which was forced to rely on a multitude of smaller engines for propulsion since Sergei Korolev, its chief designer, insisted on using the LOX/Kerosene combination, which Glushko felt would take much more time and money to design. Glushko never did overcome the combustion instability problems of large rocket engines using kerosene propellants; his eventual solution for this is seen on the RD-170 which is basically four smaller combustion chamber/nozzle assemblies sharing common fuel delivery systems. This solution and engine gave the Soviets the large thrust propulsion needed to build the Energia super heavy-lift launch vehicle, and is probably the finest example of Glushko's technical abilities when he was at his best.
https://en.wikipedia.org/wiki?curid=957500
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James Mackenzie was born at Pictonhill in Scone, where his father was a farmer. He left school at Perth Academy aged 14 and was apprenticed to a chemist. In 1873 he was offered a partnership in the chemist's firm but turned it down in order to study medicine. After private tuition in Latin he passed his entrance examination for the University of Edinburgh in October 1874 and qualified as a doctor in 1878. After completing his residency in Edinburgh, Mackenzie became a general practitioner in borough of Burnley in Lancashire, England where he continued to practice medicine for more than a quarter of a century. While he was engaged in a busy practice, he made many original observations, completed his MD degree on hemi-paraplegia spinalis (awarded by the University of Edinburgh in 1882) and had many scientific papers published. During Mackenzie's initial research carried out in the Burnley general practice he corresponded and discussed his findings with other well known pioneers Wenkebach and Osler. Mackenzie's ongoing investigations led him to leave general practice and become a specialist cardiologist. He expressed prophetic concerns about the specialisation of medicine including cardiology stating: 'I fear the day may come when a heart specialist will no longer be a physician looking at the body as a whole, but one with more and more complicated instruments working in a narrow and restricted area of the body – that was never my idea'.
https://en.wikipedia.org/wiki?curid=14892699
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Pedro Berrizbeitia (born in Caracas on December 11, 1959). He received his bachelor's degree in mathematics from Simón Bolívar University in 1981 and his doctorate from the Massachusetts Institute of Technology in 1986. He is Professor of the Department of Pure Mathematics And Applied Sciences of the Simón Bolívar University. Berrizbeitia's works cover a wide range of mathematical topics, from algebra to graph theories, but his most compelling contributions are those dealing with the additive theory of numbers and the theory of proofs of primality. He has published 17 scientific articles in prestigious international journals in the field of Mathematics and two monographs on proofs of primality and number theory. He has been a visiting professor at universities in the United States and Spain and has been a guest lecturer on ten occasions, by universities and research centers in those countries, in addition to Uruguay and Chile, and has also given twelve invited conferences at various events in Venezuela. He has conducted six master's theses in Mathematics and received Honorable Mention for the best scientific work awarded by CONICIT in 1992. He is a reviewer of the important international publication ""Mathematical Reviews" "and member of the System of Promotion to the Researcher, Level II.
https://en.wikipedia.org/wiki?curid=29302481
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As stated above, there are three different doctoral degrees for school psychology, PhD., Psy.D., and Ed.D. Career options for those with a PhD. may include being a school psychologist with a license at any level (preschool, primary, secondary or after), a professor for school psychology graduate students and/or screening for possible recruits for a school psychology program or a postdoctoral resident. Overall, those with a PhD. have more opportunities for leadership positions. Those with this degree can work in settings other than schools. Those with a PhD. are more likely to create student development workgroups and review proposals for conventions. They have been known to become editors for Best Practices, work with the editors in chief of journals, members of the NASP Communique Editorial Board, reviewers for the National School Psychology Certification Board and part of NASP's Social Justice Committee. Some school psychologists choose to continue practicing in a K-12 setting but encourage more trained school staff for professional development i.e for functional behavioral assessments and behavior intervention plans. Those who have obtained a PhD. have a greater opportunity to conduct comprehensive neuropsychological evaluations for educational and forensic purposes, review medical/legal records for forensic evaluations, and see clients for therapy. These individuals may even develop new rating scales to the field. Those with this degree have the opportunity to be recognized as a member of the American Psychological Association.
https://en.wikipedia.org/wiki?curid=482388
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In a preliminary draft during the early planning stages of the animated series, staff suggested the existence of two ancient prehistoric civilizations that appeared on Earth before humans, both of whom were equipped with advanced technologies. The Evangelions in the original scenario would have been created by the first civilization, known as the First Ancestral Race, and would have rebelled against their creators, causing their extinction. The Second Ancestral Race would have created a weapon known as the Longinus Spear in an attempt to defeat the humanoids, scattering warriors named Angels in a state of hibernation around the globe as a countermeasure in case anyone tried to reactivate the Evangelions. The Eva units were conceived from the beginning as living beings and dangerous androids rather than simple weapons; the scenario was designed to contain elements similar to those in video games or role-playing games, such as the weapons of the units being hidden in the buildings of Tokyo-3. In the last episodes, there should have been a lunar battle against twelve Angels, an idea that was later abandoned and recycled for the clash between Eva-02 and the Eva series, introduced in the 1997 theatrical conclusion. The American continent and the Eva-06 would vanish, while the ancient remains of a ruin named Arqa would be revealed. In the second half of the story, there would be preparations to invade an enemy stronghold along the lines of a role-playing game. One of the preliminary drafts of the twenty-fourth episode, written by screenwriter Akio Satsukawa, also introduced a prototype mini Evangelion, a five-meter mecha named αーTYPEーEVA000 (also known as α Eva). When the α Eva goes berserk, it would have attacked with animal fury the Angel Kaworu Nagisa, who would have dodged his blows in a scene inspired by the legend of the samurai Benkei on the Gojo Bridge; at the end of the fight, the Evangelion would have swallowed the Angel Tabris and Rei Ayanami, to be then violently disemboweled by the Prog-Knife of Shinji Ikari's Eva-01. In another proposal there were two units called 05 and 06, both manufactured in Germany, while the Evangelion after 01 would be equipped with a power system known as a positron engine.
https://en.wikipedia.org/wiki?curid=577372
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Russell and Burch writing six decades ago could not have anticipated some of the technologies that have emerged today. One of these technologies, 3D cell cultures, also known as organoids or mini-organs, have replaced animal models for some types of research. In recent years, scientists have produced organoids that can be used to model disease and test new drugs. Organoids grow "in vitro" on scaffolds (biological or synthetic hydrogels such as Matrigel) or in a culture medium. Organoids are derived from three kinds of human or animal stem cells—embryonic pluripotent stem cells (ESCs), adult somatic stem cells (ASCs), and induced pluripotent stem cells (iPSCs). These organoids are grown in vitro and mimic the structure and function of different organs such as the brain, liver, lung, kidney, and intestine. Organoids have been developed to study infectious disease. Scientists at Johns Hopkins University have developed mini-brain organoids to model how COVID-19 can affect the brain. Researchers have used brain organoids to model how the Zika virus disrupt fetal brain development. Tumoroids—3D cell cultures derived from cells biopsied from human patients—can be used in studying the genomics and drug resistance of tumors in different organs. Organoids are also used in modeling genetic diseases such as cystic fibrosis, neurodegenerative diseases such as Alzheimer's and Parkinson's, infectious diseases such as MERS-CoV and norovirus, and parasitic infections such as "Toxoplasma gondii". Human- and animal-cell-derived organoids are also used extensively in pharmacological and toxicological research.
https://en.wikipedia.org/wiki?curid=40251468
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Bob White is also a Fellow of St Edmund's College, Cambridge, prior to which he was a student and Research Fellow at Emmanuel College, Cambridge. A Fellow of the Geological Society, and a member of the American Geophysical Union and several other professional bodies; he serves on numerous of their committees. He leads a research group investigating the Earth's dynamic crust. His most cited paper (White & McKenzie 1989) used geophysical evidence in conjunction with models of melt generation beneath rifts to show that the largest and most rapid effusions of volcanic rock on the earth, known as flood basalts, result from continental rifting above mantle plumes. He has organised fieldwork in many different countries and supervised 50 PhD students at the Department of Earth Sciences in Cambridge, many of whom are now prominent in academia, industry, government and education. His work at sea has taken him to the Atlantic, Indian and Pacific Oceans and his research group is currently investigating the internal structure of volcanoes in Iceland, New Zealand, the Faroes and the Atlantic margin. His scientific work is published in over 350 papers and articles.
https://en.wikipedia.org/wiki?curid=10189113
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In 2022, the faculty offers nine [[bachelor]]'s (BA, BSc) and eight [[master]]'s (MA, MSc) [[degree]]s. [[Student]]s can choose from a wide range of [[higher education]] [[course]]s - [[technical]] [[higher]] [[education]], [[television]] [[programme]] [[production]] - and further [[education course]]s, while the [[Breuer]] Marcell [[Doctor]]al [[School]]offers a [[PhD]] in [[architecture]] in addition to the [[DLA]] in [[civil engineering]]. In 2013, the faculty organised the first [[English]]-language courses in the [[architecture]] programme, and in the years since then the number of foreign students coming to MIK from all over the world has grown to more than 500. The faculty offers 12 courses in [[English]], and the [[Master]]’s in [[Biomedical Engineering]], launched in [[September]] [[2021]], specifically in [[English]]. The Pollack [[Expo]], which has been held every year since [[2007]] instead of the previously separate Construction, [[Civil Engineering]] and [[Mechanical]], [[Electrical]] and [[Computer]] [[Engineering]] Days, has gained national recognition, attracting thousands of visitors. The event, which combines a trade exhibition, international and national conferences, training courses for engineers and [[job fair]]s, is a meeting place for [[university]], [[industry]] and [[engineering]] communities in the [[spirit]] of [[tradition]], [[innovation]] and [[cooperation]].
https://en.wikipedia.org/wiki?curid=2519422
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In 1949, Dart recommended splitting a presumed-female facial fragment from Makapansgat, South Africa, (MLD 2) into a new species as ""A. prometheus"". In 1954, he referred another presumed-female specimen from Makapansgat (a jawbone fragment). However, in 1953, South African palaeontologist John Talbot Robinson believed that splitting species and genera on such fine hairs was unjustified, and that australopithecine remains from East Africa recovered over the previous couple of decades were indistinguishable from ""Plesianthropus""/"A. africanus". Based on this, in 1955, Dart agreed with synonymising ""A. prometheus"" with "A. africanus" because they are already quite similar to each other, and if speciation did not occur across a continent, then it quite unlikely occurred over a couple tens of kilometres according to Dart. The East African remains would be split off into "A. afarensis" in 1978. In 2008, palaeoanthropologist Ronald J. Clarke recommended reviving ""A. prometheus"" to house the StW 573 nearly-complete skeleton ("Little Foot"), StS 71 cranium, StW 505 cranium, StW 183 maxilla, StW 498 maxilla and jawbone, StW 384 jawbone, StS 1 palate, and MLD 2. In 2018, palaeoanthropologists Lee Rogers Berger and John D. Hawks considered ""A. prometheus"" a "nomen nudum" ("naked name"), and has not been properly described with diagnostic characteristics which separate it from "A. africanus". At the time, these remains were dated to 3.3 million years ago in the Late Pliocene. In 2019, Clarke and South African palaeoanthropologist Kathleen Kuman redated StW 573 to 3.67 million years ago, making it the oldest "Australopithecus" specimen from South Africa. They considered its antiquity further evidence of species distinction, drawing parallels with "A. anamensis" and "A. afarensis" from Middle Pliocene East Africa. Little foot is the most complete early hominin skeleton ever recovered, with about 90% preserved.
https://en.wikipedia.org/wiki?curid=1627000
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Zinc is somewhat less dense than iron and has a hexagonal crystal structure. The metal is hard and brittle at most temperatures but becomes malleable between . Above , the metal becomes brittle again and can be pulverized by beating. Zinc is a fair conductor of electricity. For a metal, zinc has relatively low melting () and boiling points (). Cadmium is similar in many respects to zinc but forms complex compounds. Unlike other metals, cadmium is resistant to corrosion and as a result it is used as a protective layer when deposited on other metals. As a bulk metal, cadmium is insoluble in water and is not flammable; however, in its powdered form it may burn and release toxic fumes. Mercury has an exceptionally low melting temperature for a d-block metal. A complete explanation of this fact requires a deep excursion into quantum physics, but it can be summarized as follows: mercury has a unique electronic configuration where electrons fill up all the available 1s, 2s, 2p, 3s, 3p, 3d, 4s, 4p, 4d, 4f, 5s, 5p, 5d and 6s subshells. As such configuration strongly resists removal of an electron, mercury behaves similarly to noble gas elements, which form weak bonds and thus easily melting solids. The stability of the 6s shell is due to the presence of a filled 4f shell. An f shell poorly screens the nuclear charge that increases the attractive Coulomb interaction of the 6s shell and the nucleus (see lanthanide contraction). The absence of a filled inner f shell is the reason for the somewhat higher melting temperature of cadmium and zinc, although both these metals still melt easily and, in addition, have unusually low boiling points. Gold has atoms with one less 6s electron than mercury. Those electrons are more easily removed and are shared between the gold atoms forming relatively strong metallic bonds.
https://en.wikipedia.org/wiki?curid=487510
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Antioxidant polymer stabilizers are widely used to prevent the degradation of polymers such as rubbers, plastics and adhesives that causes a loss of strength and flexibility in these materials. Polymers containing double bonds in their main chains, such as natural rubber and polybutadiene, are especially susceptible to oxidation and ozonolysis. They can be protected by antiozonants. Solid polymer products start to crack on exposed surfaces as the material degrades and the chains break. The mode of cracking varies between oxygen and ozone attack, the former causing a "crazy paving" effect, while ozone attack produces deeper cracks aligned at right angles to the tensile strain in the product. Oxidation and UV degradation are also frequently linked, mainly because UV radiation creates free radicals by bond breakage. The free radicals then react with oxygen to produce peroxy radicals which cause yet further damage, often in a chain reaction. Other polymers susceptible to oxidation include polypropylene and polyethylene. The former is more sensitive owing to the presence of secondary carbon atoms present in every repeat unit. Attack occurs at this point because the free radical formed is more stable than one formed on a primary carbon atom. Oxidation of polyethylene tends to occur at weak links in the chain, such as branch points in low-density polyethylene.
https://en.wikipedia.org/wiki?curid=3277
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DNA and other macromolecules determine an organism's life cycle: birth, growth, maturity, decline, and death. Nutrition is necessary but not sufficient to account for growth in size, as genetics is the governing factor. At some point, virtually all organisms normally decline and die even while remaining in environments that contain sufficient nutrients to sustain life. The controlling factor must be internal and not nutrients or sunlight acting as causal exogenous variables. Organisms inherit the ability to create unique and complex biological structures; it is unlikely for those capabilities to be reinvented or to be taught to each generation. Therefore, DNA must be operative as the prime cause in this characteristic as well. Applying Boltzmann's perspective of the second law, the change of state from a more probable, less ordered, and higher entropy arrangement to one of less probability, more order, and lower entropy (as is seen in biological ordering) calls for a function like that known of DNA. DNA's apparent information-processing function provides a resolution of the Schrödinger paradox posed by life and the entropy requirement of the second law.
https://en.wikipedia.org/wiki?curid=7815174
826,533
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The broad history of health informatics has been captured in the book "UK Health Computing: Recollections and reflections", Hayes G, Barnett D (Eds.), BCS (May 2008) by those active in the field, predominantly members of BCS Health and its constituent groups. The book describes the path taken as 'early development of health informatics was unorganized and idiosyncratic'. In the early 1950s, it was prompted by those involved in NHS finance and only in the early 1960s did solutions including those in pathology (1960), radiotherapy (1962), immunization (1963), and primary care (1968) emerge. Many of these solutions, even in the early 1970s were developed in-house by pioneers in the field to meet their own requirements. In part, this was due to some areas of health services (for example the immunization and vaccination of children) still being provided by Local Authorities. The coalition government has proposed broadly to return to the 2010 strategy Equity and Excellence: Liberating the NHS (July 2010); stating: "We will put patients at the heart of the NHS, through an information revolution and greater choice and control' with shared decision-making becoming the norm: 'no decision about me without me' and patients having access to the information they want, to make choices about their care. They will have increased control over their own care records."
https://en.wikipedia.org/wiki?curid=351581
911,106
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Tavistock broke new ground in other ways, by meshing general medicine and psychiatry with Freudian and Jungian psychology and the social sciences to help the British army face various human resource problems. This gave rise to a field of scholarly research and professional intervention loosely known as psychosociology, particularly influential in France (CIRFIP). Several schools of thought and 'social clinical' practise belong to this tradition, all of which are critical of the experimental and expert mindset of social psychology. Most formulations of psychosociology share with OD a commitment to the relative autonomy and active participation of individuals and groups coping with problems of self-realization and goal effectiveness within larger organizations and institutions. In addition to this humanistic and democratic agenda, psychosociology uses concepts of psychoanalytic inspiration to address interpersonal relations and the interplay between self and group. It acknowledges the role of the unconscious in social behaviour and collective representations and the inevitable expression of transference and countertransference—language and behaviour that redirect unspoken feelings and anxieties to other people or physical objects taking part in the action inquiry.
https://en.wikipedia.org/wiki?curid=2819542
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The European Union and the European Space Agency agreed in March 2002 to fund the project, pending a review in 2003 (which was completed on 26 May 2003). The starting cost for the period ending in 2005 is estimated at €1.1 billion. The required satellites (the planned number is 30) were to be launched between 2011 and 2014, with the system up and running and under civilian control from 2019. The final cost is estimated at €3 billion, including the infrastructure on Earth, constructed in 2006 and 2007. The plan was for private companies and investors to invest at least two-thirds of the cost of implementation, with the EU and ESA dividing the remaining cost. The base "Open Service" is to be available without charge to anyone with a Galileo-compatible receiver, with an encrypted higher-bandwidth improved-precision "Commercial Service" originally planned to be available at a cost, but in February 2018 the high accuracy service (HAS) (providing Precise Point Positioning data on the E6 frequency) was agreed to be made freely available, with the authentication service remaining commercial. By early 2011 costs for the project had run 50% over initial estimates.
https://en.wikipedia.org/wiki?curid=13009
399,024
1,220,410
Samsung Aerospace (SSA) would become the second Korean company involved in the aerospace industry. SSA was originally specialized in manufacturing aircraft engines. This contrasted Korean Air who focused on aircraft assembly and maintenance. Both would become strong rivals who monopolized their own respective fields. This would change in 1984 under new government policy that would allow Daewoo Heavy Industries (DHI) and Hyundai Space and Aircraft (HYSA) to enter the aerospace industry. This was done to promote competition among the Korean conglomerates. Around this time, the dominance in South Korea's aerospace industry would begin to shift and active participation in the defense industry would arise. Korean Air would begin to lose its manufacturing edge as their experienced engineers begin to join SSA and DHI. HYSA would assemble BK 117 helicopters from Kawasaki Heavy Industries. However, this was considered an unprofitable venture as HYSA did not gain much technological assets or experience from it. SSA and DHI became emerging powers as well as rivals. This is primarily because both companies were competing to be awarded then South Korea's biggest aerospace project; license producing F-16 fighters for the South Korean air force's Korean Fighter Program (KFP). This is done to counter North Korean MiG-29s and Su-25s, as well as gain expertise in developing future fighter aircraft. In 1986, SSA was ultimately selected to cooperate with General Dynamics in co-producing F-16s between 1996 and 2000. This decision would solidify SSA's dominance in South Korea's aerospace industry. In addition, SSA would be tasked to develop the KTX-2 advanced trainer with Lockheed Martin based on the technology and experienced gained from the KFP. Moreover, in 1990, Samsung Aerospace would begin to license produce UH-60 helicopters for the South Korean Army. Meanwhile, Korean Air would be relegated to manufacturing helicopters and maintenance of US aircraft stationed in East Asia. DHI would be tasked to develop the KTX-1 basic trainer with ADD, gaining needed experience from it. HYSA was treading on thin ice; being unable to develop or acquire technologies or capabilities in manufacturing military aircraft, and were thus unable to secure government contracts. Instead, they focused on manufacturing wings and large airframes by participating in the MD-95 wing project, which itself was a difficult task for HSYA.
https://en.wikipedia.org/wiki?curid=66301957
1,219,756
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James Lovelock argued that the Viking mission would have done better to examine the Martian atmosphere than look at the soil. He theorised that all life tends to expel waste gases into the atmosphere, and as such it would be possible to theorise the existence of life on a planet by detecting an atmosphere that was not in chemical equilibrium. He concluded that there was enough information about Mars' atmosphere at that time to discount the possibility of life there. Since then, methane has been discovered in Mars' atmosphere at 10ppb, thus reopening this debate. Although in 2013 the Curiosity rover failed to detect methane at its location in levels exceeding 1.3ppb. later in 2013 and in 2014, measurements by Curiosity did detect methane, suggesting a time-variable source. The ExoMars Trace Gas Orbiter, launched in March 2016, implements this approach and will focus on detection, characterization of spatial and temporal variation, and localization of sources for a broad suite of atmospheric trace gases on Mars and help determine if their formation is of biological or geological origin. The Mars Orbiter Mission is also attempting —since late 2014— to detect and map methane on Mars' atmosphere. A press commentary argued that, if there was life at the Viking lander sites, it may have been killed by the exhaust from the landing rockets. That is not a problem for missions which land via an airbag-protected capsule, slowed by parachutes and retrorockets, and dropped from a height that allows rocket exhaust to avoid the surface. Mars Pathfinder's "Sojourner" rover and the Mars Exploration Rovers each used this landing technique successfully. The Phoenix Scout lander descended to the surface with retro-rockets, however, their fuel was hydrazine, and the end products of the plume (water, nitrogen, and ammonia) were not found to have affected the soils at the landing site.
https://en.wikipedia.org/wiki?curid=1072959
1,132,064
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McMullen was involved in the purchase of one further professional team with the Colorado Rockies. The Rockies were intended to move out of Colorado before McMullen bought the team, but a flurry of sales complicated things. Arthur Imperatore Sr. had bought the team in 1978 and planned to move them to East Rutherford, New Jersey in 1980, but he sold them to New York cable executive Peter Gilbert in 1981, who had pledged to keep the team there. However, in February of 1982, Gilbert wanted permission to move to New Jersey. It was in May that rumors spread that McMullen and a group of investors were a candidate to buy the team. They had a verbal agreement, but Gilbert listened to a meeting with George Steinbrenner before going back to McMullen, with a formal purchase occurring on May 28 that allowed the team to move to New Jersey. McMullen's team of investors included former New Jersey Governor Brendan Byrne and lawyer John C. Whitehead, and the group struck a deal with the New Jersey Sports and Exposition Authority and its Meadowlands complex for a thirty year deal. The total costs for territorial and TV payments to the three teams in the general area (New York Rangers, New York Islanders, Philadelphia Flyers) and transfer fee was reported as costing a total of more than $30 million. The team later re-christened the New Jersey Devils. He instituted the Dr. John J. McMullen Award in 1984, presented annually to "an individual or individuals who have supported amateur hockey throughout the state". In 1987, he hired Lou Lamoriello as team president, hiring him from Providence College where he had served as athletic director. Lamoriello named himself as general manager in 1987 and presided over the team for the next 28 years with McMullen allowing him to make moves on his free watch, which saw them go to their first winning season that year to reaching the Stanley Cup five times from 1995 to 2012. The team won two Stanley Cups during his ownership, in 1995 and 2000. Just before winning the second Cup, McMullen sold the team to YankeeNets. After his death, the team dedicated the 2005–06 season to him, wearing a small "JM" patch on their jerseys.
https://en.wikipedia.org/wiki?curid=6891489
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The ability to view and characterize different neural cells including microglia began in 1880 when Nissl staining was developed by Franz Nissl. Franz Nissl and William Ford Robertson first described microglial cells during their histology experiments. The cell staining techniques in the 1880s showed that microglia are related to macrophages. The activation of microglia and formation of ramified microglial clusters was first noted by Victor Babeş while studying a rabies case in 1897. Babeş noted the cells were found in a variety of viral brain infections but did not know what the clusters of microglia he saw were. The Spanish scientist Santiago Ramón y Cajal defined a "third element" (cell type) besides neurons and astrocytes. Pío del Río Hortega, a student of Santiago Ramón y Cajal, first called the cells "microglia" around 1920. He went on to characterize microglial response to brain lesions in 1927 and note the "fountains of microglia" present in the corpus callosum and other perinatal white matter areas in 1932. After many years of research Rio Hortega became generally considered as the "Father of Microglia." For a long period of time little improvement was made in our knowledge of microglia. Then, in 1988, Hickey and Kimura showed that perivascular microglial cells are bone-marrow derived, and express high levels of MHC class II proteins used for antigen presentation. This confirmed Pio Del Rio-Hortega's postulate that microglial cells functioned similarly to macrophages by performing phagocytosis and antigen presentation.
https://en.wikipedia.org/wiki?curid=1552187
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David Dunning and Justin Kruger published the initial study in 1999 under the title "Unskilled and Unaware of It: How Difficulties in Recognizing One's Own Incompetence Lead to Inflated Self-Assessments". It examines the performance and self-assessment of undergraduate students of introductory courses in psychology in the fields of inductive, deductive, and abductive logical reasoning, English grammar, and personal sense of humor. Across four studies, the research indicates that the participants who scored in the bottom quartile overestimated their test performance and their abilities; despite test scores that placed them in the 12th percentile, the participants estimated they ranked in the 62nd percentile. It proposes the metacognitive explanation of the observed tendencies and points out that training in a task, such as solving a logic puzzle, increases people's ability to accurately evaluate how good they are at it. It does not yet contain the term "Dunning–Kruger effect", which was introduced later. Dunning was inspired to engage in this research after reading a newspaper report about incompetent bank robbers and set up a research program soon afterward together with Kruger, who was his graduate student at the time.
https://en.wikipedia.org/wiki?curid=2288777
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Salam had a prolific research career in theoretical and high-energy physics. Salam had worked on theory of the neutrino – an elusive particle that was first postulated by Wolfgang Pauli in the 1930s. Salam introduced chiral symmetry in the theory of neutrinos. The introduction of chiral symmetry played crucial role in subsequent development of the theory of electroweak interactions. Salam later passed his work to Riazuddin, who made pioneering contributions in neutrinos. Salam introduced the massive Higgs bosons to the theory of the Standard Model, where he later predicted the existence of proton decay. In 1963, Salam published his theoretical work on the vector meson. The paper introduced the interaction of vector meson, photon (vector electrodynamics), and the renormalisation of vector mesons' known mass after the interaction. In 1961, Salam began to work with John Clive Ward on symmetries and electroweak unification. In 1964, Salam and Ward worked on a Gauge theory for the weak and electromagnetic interaction, subsequently obtaining SU(2) × U(1) model. Salam was convinced that all the elementary particle interactions are actually the gauge interactions. In 1968, together with Weinberg and Sheldon Glashow, Salam formulated the mathematical concept of their work. While in Imperial College, Salam, along with Glashow and Jeffrey Goldstone, mathematically proved the Goldstone's theorem, that a massless spin-zero object must appear in a theory as a result of spontaneous breaking of a continuous global symmetry. In 1967-8, Salam and Weinberg incorporated the Higgs mechanism into Glashow's discovery, giving it a modern form in electroweak theory, and thus theorised half of the Standard Model. In 1968, together with Weinberg and Sheldon Glashow, Salam finally formulated the mathematical concept of their work.
https://en.wikipedia.org/wiki?curid=304427
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Californian congressman Duncan D. Hunter wrote that the purchase of 55 LCS units was made at the cost of 10 fewer amphibious vessels. Assistant Commandant of the Marine Corps, General Joseph Dunford said in 2011 that the LCS is one of the platforms under consideration to help close the gap in amphibious shipping. In August 2014, USS "Coronado" demonstrated the ability to rapidly stage and deploy Marine Corps ground units, including operations by two Marine Light Attack Helicopter Squadrons (HMLA) that conducted day and night deck-landing qualifications. The "Independence"-class LCS's features of high speed, a large flight deck to support UH-1Y Venom and AH-1W Super Cobra helicopters, and reconfigurable mission bay can support air and small-boat employment and delivery of ground and air forces; a small Marine ground unit can be carried within an embarked mission module. In 2014, Marine Corps General John M. Paxton, Jr. claimed several deficiencies in using an LCS for amphibious operations as a substitute platform for an amphibious assault ship, including the ability to operate in difficult sea states, survivability in contested waters, limited flight deck and berthing space, and command and control limitations.
https://en.wikipedia.org/wiki?curid=460005
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BAFF is a 285-amino acid long peptide glycoprotein which undergoes glycosylation at residue 124. It is expressed as a membrane-bound type II transmembrane protein on various cell types including monocytes, dendritic cells and bone marrow stromal cells. The transmembrane form can be cleaved from the membrane, generating a soluble protein fragment. BAFF steady-state concentrations depend on B cells and also on the expression of BAFF-binding receptors. BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. These receptors are expressed mainly on mature B lymphocytes and their expression varies in dependence of B cell maturation (TACI is also found on a subset of T-cells and BCMA on plasma cells). BAFF-R is involved in the positive regulation during B cell development. TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). BCMA displays an intermediate binding phenotype and will work with either BAFF or APRIL to varying degrees. Signaling through BAFF-R and BCMA stimulates B lymphocytes to undergo proliferation and to counter apoptosis. All these ligands act as homotrimers (i.e. three of the same molecule) interacting with homotrimeric receptors, although BAFF has been known to be active as either a hetero- or homotrimer (can aggregate into 60-mer depending on the primary structure of the protein).
https://en.wikipedia.org/wiki?curid=10805442
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The theory of computation concerns abstract models of computation and general classes of problems that can be solved using them. The fields of cryptography and computer security involve studying the means for secure communication and for preventing security vulnerabilities. Computer graphics and computational geometry address the generation of images. Programming language theory considers different ways to describe computational processes, and database theory concerns the management of repositories of data. Human–computer interaction investigates the interfaces through which humans and computers interact, and software engineering focuses on the design and principles behind developing software. Areas such as operating systems, networks and embedded systems investigate the principles and design behind complex systems. Computer architecture describes the construction of computer components and computer-operated equipment. Artificial intelligence and machine learning aim to synthesize goal-orientated processes such as problem-solving, decision-making, environmental adaptation, planning and learning found in humans and animals. Within artificial intelligence, computer vision aims to understand and process image and video data, while natural language processing aims to understand and process textual and linguistic data.
https://en.wikipedia.org/wiki?curid=5323
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Nanotechnology is impacting the field of consumer goods, several products that incorporate nanomaterials are already in a variety of items; many of which people do not even realize contain nanoparticles, products with novel functions ranging from easy-to-clean to scratch-resistant. Examples of that car bumpers are made lighter, clothing is more stain repellant, sunscreen is more radiation resistant, synthetic bones are stronger, cell phone screens are lighter weight, glass packaging for drinks leads to a longer shelf-life, and balls for various sports are made more durable. Using nanotech, in the mid-term modern textiles will become "smart", through embedded "wearable electronics", such novel products have also a promising potential especially in the field of cosmetics, and has numerous potential applications in heavy industry. Nanotechnology is predicted to be a main driver of technology and business in this century and holds the promise of higher performance materials, intelligent systems and new production methods with significant impact for all aspects of society.
https://en.wikipedia.org/wiki?curid=7067473
1,156,297
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The operational concept of EBF is to build a near-net-shape metal part directly from a computer-aided design (CAD) file. Current computer-aided machining practices start with a CAD model and use a post-processor to write the machining instructions (G-code) defining the cutting tool paths needed to make the part. EBF uses a similar process, starting with a CAD model, numerically reducing it into layers, then using a post-processor to write the G-code defining the deposition path and process parameters for the EBF equipment. It uses a focused electron beam in a vacuum environment to create a molten pool on a metallic substrate. The beam is translated in accordance with the surface of the substrate while metal wire is fed into the molten pool. The deposit solidifies immediately after the electron beam has passed, having sufficient structural strength to support itself. The sequence is repeated in a layer-additive manner to produce a near-net-shape part needing only finish machining. The EBF process is scalable for components from fractions of an inch to tens of feet in size, limited mainly by the size of the vacuum chamber and amount of wire feedstock available.
https://en.wikipedia.org/wiki?curid=23608428
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In 1870, Rudolf Clausius delivered the lecture "On a Mechanical Theorem Applicable to Heat" to the Association for Natural and Medical Sciences of the Lower Rhine, following a 20-year study of thermodynamics. The lecture stated that the mean vis viva of the system is equal to its virial, or that the average kinetic energy is equal to the average potential energy. The virial theorem can be obtained directly from Lagrange's identity as applied in classical gravitational dynamics, the original form of which was included in Lagrange's "Essay on the Problem of Three Bodies" published in 1772. Karl Jacobi's generalization of the identity to "N" bodies and to the present form of Laplace's identity closely resembles the classical virial theorem. However, the interpretations leading to the development of the equations were very different, since at the time of development, statistical dynamics had not yet unified the separate studies of thermodynamics and classical dynamics. The theorem was later utilized, popularized, generalized and further developed by James Clerk Maxwell, Lord Rayleigh, Henri Poincaré, Subrahmanyan Chandrasekhar, Enrico Fermi, Paul Ledoux, Richard Bader and Eugene Parker. Fritz Zwicky was the first to use the virial theorem to deduce the existence of unseen matter, which is now called dark matter. Richard Bader showed the charge distribution of a total system can be partitioned into its kinetic and potential energies that obey the virial theorem. As another example of its many applications, the virial theorem has been used to derive the Chandrasekhar limit for the stability of white dwarf stars.
https://en.wikipedia.org/wiki?curid=32664
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Although individuals between cycles are generally healthy and symptoms tend to improve in adulthood, it is advised avoiding activities prone to injuries, to have regular oral and dental care, and BCG vaccine to be avoided. It is advised monitoring white blood cells several times a year. The treatment following the symptoms should be immediate to prevent infections, especially during a fever when it requires broad-spectrum antibiotic therapy (see febrile neutropenia). The most important and often life-saving treatment is the preventive therapy of granulocyte colony-stimulating factor (G-CSF), in the form of filgrastim, which regulates the production of neutrophils within the bone marrow, but shortens the neutropenic cycle to about 7-14 days and the duration of the severe condition. The subcutaneous injections, with median dosage of 1.5 μg/kg/day, can be given daily, intermittently once every three days, or timed to just treat the neutropenic period. The therapy is considered to be "safe and effective", with no significant adverse effects, besides a possibility of development of osteopenia.
https://en.wikipedia.org/wiki?curid=2317059
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Following the resignation of Mell in 1910 former Clemson Tigers football coach Walter Riggs became president of Clemson from 1910 to 1924. The Holtzendorff Hall, originally the Holzendorff YMCA, was built in 1914 designed by Rudolph E. Lee of the first graduating class of Clemson in 1896. In 1915 Riggs Field was dedicated after Walter Riggs and is the Clemson Tigers men's soccer home field. During World War I enrollment in Clemson declined. In 1917 Clemson formed a Reserve Officers' Training Corps and in 1918 a Student Army Training Corps was formed. Effects of World War I made Clemson hire the first women faculty due to changes in faculty. Riggs accepted a six-month army educational commission in 1919 overseas in France leaving Samuel Earle as acting president. On March 10, 1920, a large walkout occurred protesting unfair "prison camp" style military discipline. The 1920 walkout led to the creation of a Department of Student Affairs. On January 22, 1924, Riggs died on a business trip to Washington, D.C. leaving Earle the acting president. In October 1924 another walkout of around 500 students occurred when Earle rejected their demands of better food and the dismissal of mess officer Harcombe and the reinstatement of their senior class president. The 1924 walkout resulted in 23 students dismissed and 112 suspended.
https://en.wikipedia.org/wiki?curid=147456
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TASC sought a judicial review of the East Suffolk Council's decision to grant planning permission in September 2019 for preparatory works on the site, which would involve the felling of 229 trees as well as the demolition of buildings on the Sizewell B site. The group claimed that the decision was unlawful and that proper investigations into the potential scale of environmental damage had not occurred. The bid to block the works were brought forwards by a local resident, Joan Girling, on behalf of TASC to the High Court. The court heard the case on 8 September 2020, and ruled that the habitat loss would be "minor" and "not significant". Mr Justice Holgate rejected the attempt to block the works, and said that he "did not accept East Suffolk Council acted irrationally". An EDF spokesperson responded to the rulings by saying that "The judge acknowledged the robust nature of the report provided by East Suffolk Council regarding the environmental impact of the work. The report, which was informed by the council arboriculturist, found that the majority (73%) of the 229 trees that need to be removed from Coronation Wood are low quality plantation wood with a limited life expectancy and limited amenity value. It was judged that this loss would be 'balanced' by the planting of over 2,500 juvenile woodland trees, including a mixture of broadleaf and coniferous species appropriate for the prevailing soil and coastal conditions."
https://en.wikipedia.org/wiki?curid=64508802
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Until the 1970s, the design of towns and cities took little account of the needs of people with disabilities. At that time, disabled people began to form movements demanding recognition of their potential contribution if social obstacles were removed. Disabled people challenged the 'medical model' of disability which saw physical and mental problems as an individual 'tragedy' and people with disabilities as 'brave' for enduring them. They proposed instead a 'social model' which said that barriers to disabled people result from the design of the built environment and attitudes of able-bodied people. 'Access Groups' were established composed of people with disabilities who audited their local areas, checked planning applications, and made representations for improvements. The new profession of 'access officer' was established around that time to produce guidelines based on the recommendations of access groups and to oversee adaptations to existing buildings as well as to check on the accessibility of new proposals. Many local authorities now employ access officers who are regulated by the Access Association. A new chapter of the Building Regulations (Part M) was introduced in 1992. Although it was beneficial to have legislation on this issue the requirements were fairly minimal but continue to be improved with ongoing amendments. The Disability Discrimination Act 1995 continues to raise awareness and enforce action on disability issues in the urban environment.
https://en.wikipedia.org/wiki?curid=50345
1,006,972
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PGH differs from common PGD methods such as fluorescence "in situ" hybridization (FISH) and polymerase chain reaction (PCR) for two primary reasons. First, rather than focusing on the genetic makeup of an embryo PGH compares the genome of affected and unaffected members of previous generations. This examination of generational variation then allows for a haplotype of genetic markers statistically associated with the target disease to be identified, rather than searching merely for a mutation. PGH is often used to reinforce other methods of genetic testing, and is considered more accurate than certain more common PGD methods because it has been found to reduce risk of misdiagnoses. Studies have found that misdiagnoses due to allele dropout (ADO), one of the most common causes of interpretation error, can be almost eliminated through use of PGH. Further, in the case of mutation due to translocation, PGH is able to detect chromosome abnormality to its full extent by differentiating between embryos carrying balanced forms of a translocation versus those carrying the homologous normal chromosomes. This is an advantage because PGD methods such as FISH are able to reveal whether an embryo will express the phenotypic difference, but not whether an embryo may be a carrier. In 2015, PGH was used in conjunction with a whole-genome amplification (WGA) process to not only diagnose disease but also distinguish meiotic segregation errors from mitotic ones.
https://en.wikipedia.org/wiki?curid=5630419
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The motto of the German-Egyptian Year of Science and Technology was 'Linking Scientific Masterminds'. It was jointly launched by the Research Ministers of both countries on 15 January 2007 in Cairo. Its aim was to bring together scientists, initiate joint research projects and launch bilateral research projects that would strengthen scientific cooperation well beyond 2007. Six research networks in the fields of materials sciences, water, renewable energy, biotechnology, health research and the arts and social sciences represented the core fields of the Year of Science. The application focus and industrial relevance of the bilateral projects in particular were strengthened. In addition, the involvement of new university and non-university partners in Egypt provided a broader basis for cooperation. Examples include the implementation of a German-Egyptian Research Fund (GERF) or the German University of Cairo (GUC). The German-Egyptian Year of Science and Technology and the more than 150 associated events were well received by scientists and scholars as well as the general public. These events included the opening ceremony in Cairo, the multimedia show "Culturama" in Berlin, the open day on the research vessel METEOR in Port Said, the centennial celebration of the German Archaeological Institute in Cairo, the exhibition “Egypt’s Sunken Treasures” in Bonn, and the exhibition of mummies and an accompanying academic programme at the Landesmuseum in Stuttgart. As a gateway to the Arab world, Egypt remains one of Germany's most important partner countries in the Middle East. The German University in Cairo opened a campus in Berlin in January 2013.
https://en.wikipedia.org/wiki?curid=40565294
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Thomas and Nell Lafferre Hall is the main building of the MU College of Engineering, with F. Robert and Patricia Naka Hall and Engineering Building North providing additional classroom, laboratory and office space. Lafferre Hall has been named for College of Engineering alumnus Thomas Lafferre and his wife, Nell, since 2004. The original buildings that provide the foundation of what is now Lafferre Hall were built in 1892 and 1893, with additions constructed in 1935, 1944, 1958, 1991 and 2009. In 2014, the State of Missouri's Board of Public Buildings — Governor Jay Nixon, Lieutenant Governor Peter Kinder and Attorney General Chris Koster — approved $38.5 million in bonds issued by the Missouri General Assembly for renovations and repairs to Lafferre Hall. Demolition of the 1935 and 1944 sections of the building began in May 2015, and the project was expected to be finished by December 2016. The renovation was to "allow for space to accommodate student competition teams, student conference rooms and study spaces on the main floor, alongside expanded laboratory space to better accommodate research. The building's various additions will be connected, and the project will make the entire building accessible according to the guidelines set forth by the Americans with Disabilities Act." The College held a ribbon cutting for the newly-renovation section of the building in December 2016.
https://en.wikipedia.org/wiki?curid=35931597
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As the aircraft fuselage and control surfaces will also add drag and possibly some lift, it is fair to consider the L/D of the aircraft as a whole. As it turns out, the glide ratio, which is the ratio of an (unpowered) aircraft's forward motion to its descent, is (when flown at constant speed) numerically equal to the aircraft's L/D. This is especially of interest in the design and operation of high performance sailplanes, which can have glide ratios almost 60 to 1 (60 units of distance forward for each unit of descent) in the best cases, but with 30:1 being considered good performance for general recreational use. Achieving a glider's best L/D in practice requires precise control of airspeed and smooth and restrained operation of the controls to reduce drag from deflected control surfaces. In zero wind conditions, L/D will equal distance traveled divided by altitude lost. Achieving the maximum distance for altitude lost in wind conditions requires further modification of the best airspeed, as does alternating cruising and thermaling. To achieve high speed across country, glider pilots anticipating strong thermals often load their gliders (sailplanes) with water ballast: the increased wing loading means optimum glide ratio at greater airspeed, but at the cost of climbing more slowly in thermals. As noted below, the maximum L/D is not dependent on weight or wing loading, but with greater wing loading the maximum L/D occurs at a faster airspeed. Also, the faster airspeed means the aircraft will fly at greater Reynolds number and this will usually bring about a lower zero-lift drag coefficient.
https://en.wikipedia.org/wiki?curid=293639
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"Aspergillus alabamensis" is able to cause aspergillosis, although this species is rarely differentiated from the morphologically similar "A. terreus" because morphological studies are routinely used to identify and distinguish different clinical Aspergilli. The adoption of DNA sequence-based analysis of critical genes such as β-tubulin and calmodulin is likely to expand the number of case reports of this and other cryptic agents of aspergillosis. Notwithstanding, proper identification remains difficult due to the complexity involved in the sequencing process as well as the relatively high costs associated with these advanced techniques. Recent studies have found that the crude extract of "A. alabamensis" cultures to exhibit antiisectan properties. Samples derived from a dead hardwood branch near a river in northern Florida produced dioxomorpholines which showed insect repelling activity against "Spodoptera frugiperda". Similar to "A. terreus", "A. alabamensis" exhibits a high minimum inhibitory concentration (MIC) to the antifungal drug amphotericin B though it is generally thought susceptible to other antifungal drugs such as voriconazole, itraconazole, and echinocandins.
https://en.wikipedia.org/wiki?curid=52734204
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Previously nanocapsules containing herbicides have been reported to effectively penetrate through cuticles and tissues, allowing the slow and constant release of the active substances. Likewise, other literature describes that nano-encapsulated slow release of fertilizers has also become a trend to save fertilizer consumption and to minimize environmental pollution through precision farming. These are only a few examples from numerous research works which might open up exciting opportunities for nanobiotechnology application in agriculture. Also, application of this kind of engineered nanoparticles to plants should be considered the level of amicability before it is employed in agriculture practices. Based on a thorough literature survey, it was understood that there is only limited authentic information available to explain the biological consequence of engineered nanoparticles on treated plants. Certain reports underline the phytotoxicity of various origin of engineered nanoparticles to the plant caused by the subject of concentrations and sizes . At the same time, however, an equal number of studies were reported with a positive outcome of nanoparticles, which facilitate growth promoting nature to treat plant. In particular, compared to other nanoparticles, silver and gold nanoparticles based applications elicited beneficial results on various plant species with less and/or no toxicity. Silver nanoparticles (AgNPs) treated leaves of Asparagus showed the increased content of ascorbate and chlorophyll. Similarly, AgNPs-treated common bean and corn has increased shoot and root length, leaf surface area, chlorophyll, carbohydrate and protein contents reported earlier. The gold nanoparticle has been used to induce growth and seed yield in Brassica juncea.
https://en.wikipedia.org/wiki?curid=2154572
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Saturday's afternoon one hour qualifying session saw each driver limited to twelve laps, with the starting order decided by their fastest laps. During this session, the 107% rule was in effect, which necessitated each driver set a time within 107 per cent of the quickest lap to qualify for the race. The session was held in dry weather. Michael Schumacher achieved his sixth pole position of the season, and the 29th of his career, with a time of 1:23.770. Although he was happy with his car and tyres, he said that he did not make the best of session because of making a mistake at the first chicane during his first run. Michael Schumacher was joined on the front row by Barrichello who recorded a lap time 0.027 seconds slower with ten minutes left and was happy to start alongside his teammate. Häkkinen qualified third after having handling difficulties and his McLaren misfiring with a fuel pressure fault which distracted him during his final two timed laps. Villeneuve achieved BAR's best qualifying performance at the time in fourth on his final fast lap with 12 minutes remaining, nearly half a second behind Michael Schumacher. He said he was happy with his performance despite a minor error on his first run. Häkkinen's teammate Coulthard took fifth after encountering traffic during qualifying and vehicle balance problems. He was blocked by Frentzen leaving the Rettifilo chicane on his last run. Trulli and Frentzen set the sixth and eighth fastest times respectively for Jordan; Trulli reported no problems while Frentzen was impeded by De La Rosa that lost him approximately four-tenths of a second. Ralf Schumacher, seventh, expressed disappointment in his performance that saw him abort two runs due to his braking position.
https://en.wikipedia.org/wiki?curid=1123405
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Modern geology, like modern chemistry, gradually evolved during the 18th and early 19th centuries. Benoît de Maillet and the Comte de Buffon saw the Earth as much older than the 6,000 years envisioned by biblical scholars. Jean-Étienne Guettard and Nicolas Desmarest hiked central France and recorded their observations on some of the first geological maps. Aided by chemical experimentation, naturalists such as Scotland's John Walker, Sweden's Torbern Bergman, and Germany's Abraham Werner created comprehensive classification systems for rocks and minerals—a collective achievement that transformed geology into a cutting edge field by the end of the eighteenth century. These early geologists also proposed a generalized interpretations of Earth history that led James Hutton, Georges Cuvier and Alexandre Brongniart, following in the steps of Steno, to argue that layers of rock could be dated by the fossils they contained: a principle first applied to the geology of the Paris Basin. The use of index fossils became a powerful tool for making geological maps, because it allowed geologists to correlate the rocks in one locality with those of similar age in other, distant localities.
https://en.wikipedia.org/wiki?curid=14400
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Rolls-Royce began developing a lightweight military Wankel Diesel engine for the MoD in 1964. Fritz Feller was the leading engineer of the project. Soon, it became obvious that a regular Wankel engine would not be suitable for the high compression ratio needed for compression ignition, which led to the idea of using another rotary piston as a supercharger. Early tests were conducted with a modified NSU Wankel engine that was fed pre-heated compressed air to achieve compression ignition. This test engine displaced 0.25 litre and ran for 94 hours before it broke; the fuel consumption ranged from 0.84 lb/hp·h to 1.4 lb/hp·h (511 g/kW·h to 852 g/kW·h). The sealing material proved to be insufficient, leading to high sealing loss; new materials had to be engineered. Furthermore, designing a good combustion chamber, allowing good mixture of air and fuel, turned out to be considerably difficult and thus required a lot of development work. To avoid the problem of having a complicated combustion chamber in the rotor, a precombustion chamber was considered an option, but it was later abandoned, because making a housing with a proper precombustion chamber seemed unfeasible.
https://en.wikipedia.org/wiki?curid=59593680
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All armies soon deployed AA guns often based on their smaller field pieces, notably the French 75 mm and Russian 76.2 mm, typically simply propped up on some sort of embankment to get the muzzle pointed skyward. The British Army adopted the 13-pounder quickly producing new mountings suitable for AA use, the 13-pdr QF 6 cwt Mk III was issued in 1915. It remained in service throughout the war but 18-pdr guns were lined down to take the 13-pdr shell with a larger cartridge producing the 13-pr QF 9 cwt and these proved much more satisfactory. However, in general, these ad hoc solutions proved largely useless. With little experience in the role, no means of measuring target, range, height or speed the difficulty of observing their shell bursts relative to the target gunners proved unable to get their fuse setting correct and most rounds burst well below their targets. The exception to this rule was the guns protecting spotting balloons, in which case the altitude could be accurately measured from the length of the cable holding the balloon.
https://en.wikipedia.org/wiki?curid=146640
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The principle of relativity, which states that physical laws have the same form in each inertial reference frame, dates back to Galileo, and was incorporated into Newtonian physics. However, in the late 19th century, the existence of electromagnetic waves led some physicists to suggest that the universe was filled with a substance they called "aether", which, they postulated, would act as the medium through which these waves, or vibrations, propagated (in many respects similar to the way sound propagates through air). The aether was thought to be an absolute reference frame against which all speeds could be measured, and could be considered fixed and motionless relative to Earth or some other fixed reference point. The aether was supposed to be sufficiently elastic to support electromagnetic waves, while those waves could interact with matter, yet offering no resistance to bodies passing through it (its one property was that it allowed electromagnetic waves to propagate). The results of various experiments, including the Michelson–Morley experiment in 1887 (subsequently verified with more accurate and innovative experiments), led to the theory of special relativity, by showing that the aether did not exist. Einstein's solution was to discard the notion of an aether and the absolute state of rest. In relativity, any reference frame moving with uniform motion will observe the same laws of physics. In particular, the speed of light in vacuum is always measured to be "c", even when measured by multiple systems that are moving at different (but constant) velocities.
https://en.wikipedia.org/wiki?curid=26962
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Because the results of calculations based on Teller's concept were discouraging, many scientists believed it could not lead to a successful weapon, while others had moral and economic grounds for not proceeding. Consequently, several senior people of the Manhattan Project opposed development, including Bethe and Oppenheimer. To clarify the situation, Ulam and von Neumann resolved to do new calculations to determine whether Teller's approach was feasible. To carry out these studies, von Neumann decided to use electronic computers: ENIAC at Aberdeen, a new computer, MANIAC, at Princeton, and its twin, which was under construction at Los Alamos. Ulam enlisted Everett to follow a completely different approach, one guided by physical intuition. Françoise Ulam was one of a cadre of women "computers" who carried out laborious and extensive computations of thermonuclear scenarios on mechanical calculators, supplemented and confirmed by Everett's slide rule. Ulam and Fermi collaborated on further analysis of these scenarios. The results showed that, in workable configurations, a thermonuclear reaction would not ignite, and if ignited, it would not be self-sustaining. Ulam had used his expertise in combinatorics to analyze the chain reaction in deuterium, which was much more complicated than the ones in uranium and plutonium, and he concluded that no self-sustaining chain reaction would take place at the (low) densities that Teller was considering. In late 1950, these conclusions were confirmed by von Neumann's results.
https://en.wikipedia.org/wiki?curid=41531
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His work with the New York City Municipal Board of Health led to a number of important sanitary reforms in the city. When he began his services on the Board of Health in 1866, 53 out of every 100 deaths in the city were children under the age of 5. He implemented major reforms to improve infant nutrition, including stopping the sale of watered-down milk, and instituted a corps of traveling physicians to tend to the residents of tenements. By the time he left the Board, the child mortality rate had fallen to 46 out of every 100 deaths, an estimated saving of 8000 lives and 5000 children per annum. He was a strong advocate for tenement reform, designing tenement houses that were cleaner and brighter than those most prevalent in the city, and pushing a "Tenement House Act" through legislature. This is all in addition to the more mundane tasks of testing household goods such as cosmetics, patent medicine, and wallpaper for toxic and potentially harmful additives. The Board of Health, under his leadership is credited with preventing a cholera epidemic in 1883. He, himself, thought his most important work with the Board of Health was his work in reducing fatal kerosene related accidents through informing the public about the dangers of kerosene with naphtha and gasoline added (making combustible vapors). All in all, Chandler's leadership of the Board of Health marks an important chapter in the history of sanitation in New York, and his improvements were achieved against political corruption and business interests.
https://en.wikipedia.org/wiki?curid=12611495
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Gammaproteobacteria are widely distributed and abundant in various ecosystems such as soil, freshwater lakes and rivers, oceans and salt lakes. For example, Gammaproteobacteria constitute about 6–20% (average of 14%) of bacterioplankton in different oceans; plus, current researches have revealed their worldwide propagation in deep-sea and coastal sediments. In seawater, Bacterial community composition could be shaped by miscellaneous environmental parameters, such as phosphorus, total organic carbon contents, salinity, and pH, and the higher is the soil pH, the higher is the relative abundance of Alphaproteobacteria, Betaproteobacteria and Gammaproteobacteria. The relative abundance of Betaproteobacteria and Gammaproteobacteria is also positively correlated to the dissolved organic carbon (DOC) concentration, which is a key environmental parameter shaping bacterial community composition. Gammaproteobacteria are also key players in the dark carbon fixation in coastal sediments, which are the largest carbon sink on Earth and the majority of these bacteria have not been cultured yet. The deep-sea hydrothermal system is one of the most extreme environments on Earth. Almost all vent-endemic animals are strongly associated with the primary production of the endo- and/or episymbiotic chemoautotrophic microorganisms. Analyses of both the symbiotic and free-living microbial communities in the various deep-sea hydrothermal environments have revealed a predominance in biomass of members of the Gammaproteobacteria.
https://en.wikipedia.org/wiki?curid=9090953
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One of the leading groups in academy for creating ion-trap MMS is Prof. Graham Cooks with his associate Professor Zheng Ouyang at Purdue University. They have built a series of mini mass spectrometer based on quadrupole ion trap called Mini 10, Mini 11, Mini 12. The group used Mini 10 mass spectrometer weighing 10 kg to analyze proteins, peptides and alkaloids in complex plant materials with electrospray ionization ESI and paperspray ionization. The group used low radio frequency of resonant ion ejection to increase mass range up to 17,000 Da proteins. For interfacing ESI source with MMS, a 10 cm stainless steel capillary was fabricated to transfer the ions directly into the vacuum manifold. The resulting high pressure of 20 mTorr, which is several orders of magnitude higher than that used in lab-scale mass spectrometers is compensated by using the pressure-tolerant rectilinear ion trap. One of the key component of this MMS is the commercial turbo-bump and the MS can be operated at 10 torr. To overcome the problem of continuous sample introduction because of the small size of the pump, the group developed a technique called discontinuous atmospheric pressure introduction (DAPI). This technique performs direct chemical analysis without sample pretreatment and enables the coupling of miniature mass spectrometers to atmospheric pressure ionization sources, including ESI, atmospheric pressure chemical ionization (APCI), and various ambient ionization sources. The ions are transferred from ionization source and hold at a punch-valve and injected to MS periodically. The performance of a hand-held Mini-10 mass spectrometer was upgraded with negative ion mode for detecting explosive compounds and hazardous materials at the picogram level, which is highly applicable for airport luggage checking.
https://en.wikipedia.org/wiki?curid=45249739
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Bowlby was influenced by the beginnings of the object relations school of psychoanalysis and in particular, Melanie Klein, although he profoundly disagreed with the psychoanalytic belief then prevalent that saw infants' responses as relating to their internal fantasy life rather than to real life events. As Bowlby began to formulate his concept of attachment, he was influenced by case studies by Levy, Powdermaker, Lowrey, Bender and Goldfarb. An example is the one by David Levy that associated an adopted child's lack of social emotion to her early emotional deprivation. Bowlby himself was interested in the role played in delinquency by poor early relationships, and explored this in a study of young thieves. Bowlby's contemporary René Spitz proposed that "psychotoxic" results were brought about by inappropriate experiences of early care. A strong influence was the work of James and Joyce Robertson who filmed the effects of separation on children in hospital. They and Bowlby collaborated in making the 1952 documentary film "A Two-Year Old Goes to the Hospital" illustrating the impact of loss and suffering experienced by young children separated from their primary caretakers. This film was instrumental in a campaign to alter hospital restrictions on visiting by parents.
https://en.wikipedia.org/wiki?curid=18756845
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A high LPC score suggests that the leader has a "human relations orientation", while a low LPC score indicates a "task orientation". Fiedler assumes that everybody's least preferred coworker in fact is on average about equally unpleasant. But people who are indeed relationship motivated, tend to describe their least preferred coworkers in a more positive manner, e.g., more pleasant and more efficient. Therefore, they receive higher LPC scores. People who are task motivated, on the other hand, tend to rate their least preferred coworkers in a more negative manner. Therefore, they receive lower LPC scores. So, the Least Preferred Coworker (LPC) scale is actually not about the least preferred worker at all, instead, it is about the person who takes the test; it is about that person's motivation type. This is so, because, individuals who rate their least preferred coworker in relatively favorable light on these scales derive satisfaction out of interpersonal relationship, and those who rate the coworker in a relatively unfavorable light get satisfaction out of successful task performance. This method reveals an individual's emotional reaction to people they cannot work with. Critics point out that this is not always an accurate measurement of leadership effectiveness. Fiedler expanded his studies outside of the lab and showed the interrelations between adjustment, group performance and leadership style in a volunteer medical team under different conditions of stress while working in isolated villages of Central America. The task-oriented leader performed better in situations that were favorable and relatively unfavorable while the relationship-oriented leader only fared better in situations of intermediate favorableness. As the LPC is a personality measure, the score is believed to be quite stable over time and not easily changed. Low LPCs tend to remain low and high LPCs tend to remain high which shows that the test-reliability of the LPC is strong.
https://en.wikipedia.org/wiki?curid=399470
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One continued argument for technological determinism is centered on the stirrup and its impact on the creation of feudalism in Europe in the late 8th century/early 9th century. Lynn White is credited with first drawing this parallel between feudalism and the stirrup in his book "Medieval Technology and Social Change", which was published in 1962 and argued that as "it made possible mounted shock combat", the new form of war made the soldier that much more efficient in supporting feudal townships (White, 2). According to White, the superiority of the stirrup in combat was found in the mechanics of the lance charge: "The stirrup made possible- though it did not demand- a vastly more effective mode of attack: now the rider could law his lance at rest, held between the upper arm and the body, and make at his foe, delivering the blow not with his muscles but with the combined weight of himself and his charging stallion (White, 2)." White draws from a large research base, particularly Heinrich Brunner's "Der Reiterdienst und die Anfänge des Lehnwesens" in substantiating his claim of the emergence of feudalism. In focusing on the evolution of warfare, particularly that of cavalry in connection with Charles Martel's "diversion of a considerable part of the Church's vast military riches...from infantry to cavalry", White draws from Brunner's research and identifies the stirrup as the underlying cause for such a shift in military division and the subsequent emergence of feudalism (White, 4). Under the new brand of warfare garnered from the stirrup, White implicitly argues in favor of technological determinism as the vehicle by which feudalism was created.
https://en.wikipedia.org/wiki?curid=40626873
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A lot of research funded by the European Commission is being devoted to hydrometallurgical processes for the partitioning and transmutation of trivalent actinides (An). These research programs have first led to multicycle processes, secondly to the development of simplified and innovative processes. The hydrometallurgical partitioning consists of two relevant steps: extraction and stripping. In the first step the organic phase, containing the extracting ligand dissolved in a suitable solvent, is contacted with the aqueous phase coming from the dissolution of the irradiated fuel. The solutes present in the aqueous phase are extracted by a complexation reaction with the extracting agent and transferred into the organic phase in which the formed complexes are soluble. The second step, known as stripping, is obtained by reversing the complexation reaction, where the solutes are back-extracted into another aqueous solution usually different in acidity compared to the previous one. The main goal is to develop reliable and affordable industrial separation processes by lipophilic and hydrophilic ligands to selectively extract minor actinides from the (3–4) M acidic target waste downstream of the PUREX process, but with the more challenging goal to minimize the amount of solid secondary waste. The CHON principle was born to meet this further process requirement, according to which all extractants and molecular reagents used in the developed processes have only to contain atoms of carbon (C), hydrogen (H), oxygen (O) and nitrogen (N), thus incinerable waste to easily release into the environment.
https://en.wikipedia.org/wiki?curid=64345861
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Ionizing radiation has many practical uses in medicine, research, and construction, but presents a health hazard if used improperly. Exposure to radiation causes damage to living tissue; high doses result in Acute radiation syndrome (ARS), with skin burns, hair loss, internal organ failure, and death, while any dose may result in an increased chance of cancer and genetic damage; a particular form of cancer, thyroid cancer, often occurs when nuclear weapons and reactors are the radiation source because of the biological proclivities of the radioactive iodine fission product, iodine-131. However, calculating the exact risk and chance of cancer forming in cells caused by ionizing radiation is still not well understood and currently estimates are loosely determined by population based data from the atomic bombings of Hiroshima and Nagasaki and from follow-up of reactor accidents, such as the Chernobyl disaster. The International Commission on Radiological Protection states that "The Commission is aware of uncertainties and lack of precision of the models and parameter values", "Collective effective dose is not intended as a tool for epidemiological risk assessment, and it is inappropriate to use it in risk projections" and "in particular, the calculation of the number of cancer deaths based on collective effective doses from trivial individual doses should be avoided."
https://en.wikipedia.org/wiki?curid=25856
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As part of the Water Resources Development Act of 1992, Congress authorized an evaluation of the effectiveness of the Central and Southern Florida Flood Control Project. A report known as the "Restudy", written by the U.S. Army Corps of Engineers and the South Florida Water Management District, was submitted to Congress in 1999. It cited indicators of harm to the system: a 50% reduction in the original Everglades, diminished water storage, harmful timing of water release, an 85 to 90% decrease in wading bird populations over the past 50 years, and the decline of output from commercial fisheries. Bodies of water including Lake Okeechobee, the Caloosahatchee River, St. Lucie estuary, Lake Worth Lagoon, Biscayne Bay, Florida Bay, and the Everglades reflected drastic water level changes, hypersalinity, and dramatic changes in marine and freshwater ecosystems. The Restudy noted the overall decline in water quality over the past 50 years was caused by loss of wetlands that act as filters for polluted water. It predicted that without intervention the entire South Florida ecosystem would deteriorate. Canals took roughly of water to the Atlantic Ocean or Gulf of Mexico daily, so there was no opportunity for water storage, yet flooding was still a problem. Without changes to the current system, the Restudy predicted water restrictions would be necessary every other year, and annually in some locations. It also warned that revising some portions of the project without dedicating efforts to an overall comprehensive plan would be insufficient and probably detrimental.
https://en.wikipedia.org/wiki?curid=17601646
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Yonath focuses on the mechanisms underlying protein biosynthesis, by ribosomal crystallography, a research line she pioneered over twenty years ago despite considerable skepticism of the international scientific community. Ribosomes translate RNA into protein and because they have slightly different structures in microbes, when compared to eukaryotes, such as human cells, they are often a target for antibiotics. In 2000 and 2001, she determined the complete high-resolution structures of both ribosomal subunits and discovered within the otherwise asymmetric ribosome, the universal symmetrical region that provides the framework and navigates the process of polypeptide polymerization. Consequently, she showed that the ribosome is a ribozyme that places its substrates in stereochemistry suitable for peptide bond formation and for substrate-mediated catalysis. In 1993 she visualized the path taken by the nascent proteins, namely the ribosomal tunnel, and recently revealed the dynamics elements enabling its involvement in elongation arrest, gating, intra-cellular regulation and nascent chain trafficking into their folding space.
https://en.wikipedia.org/wiki?curid=38502761
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The first debate was effectively suspended in 1934 when Ruth Benedict published "Patterns of Culture", which has continuously been in print. Although this book is well known for popularizing the Boasian principle of cultural relativism, among anthropologists it constituted both an important summary of the discoveries of Boasians, and a decisive break from Boas's emphasis on the mobility of diverse cultural traits. "Anthropological work has been overwhelmingly devoted to the analysis of cultural traits," she wrote "rather than to the study of cultures as articulated wholes." Influenced by Polish-British social anthropologist Bronisław Malinowski, however, she argued that "The first essential, so it seems today, is to study the living culture, to know its habits of thought and the functions of its institutions" and that "the only way in which we can know the significance of the selected detail of behavior is against the background of the motives and emotions and values that are institutionalized in that culture." Influenced by German historians Wilhelm Dilthey and Oswald Spengler, as well as by gestalt psychology, she argued that "the whole determines its parts, not only their relation but their very nature," and that "cultures, likewise, are more than the sum of their traits." She observed that "Just as each spoken language draws very selectively from an extensive, but finite, set of sounds any human mouth (free from defect) can make, she concluded that in each society people, over time and through both conscious and unconscious processes, selected from an extensive but finite set of cultural traits which then combine to form a unique and distinctive pattern." Further, Benedict argues
https://en.wikipedia.org/wiki?curid=41831802
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One of the new technologies developed for the mission were high-tech "rulers", capable of making measurements in increments a fraction of the width of a hydrogen atom. In addition, the rulers were developed to work as a network. The mission team also created "shock absorbers" to alleviate the effects of tiny vibrations in the spacecraft which would impede accurate measurements. Another of the milestones involved combining the new "rulers" and "shock absorbers" to prove that the Space Interferometry Mission craft could detect the tiny wobbles in stars caused by Earth-sized planets. The fifth of the technology milestones required the demonstration of the Microarcsecond Metrology Testbed at a performance of 3,200 picometers over its wide angle field of view. The wide angle measurements were to be used to determine the fixed positions of stars each time they were measured. This level of performance demonstrated SIM Lite's ability to calculate the astrometric grid. Another key development, known as gridless narrow-angle astrometry (GNAA), was the ability to apply the measurement capability worked out in the wide angle milestone and take it a step further, into narrow-angle measurements. Aiming to give an accuracy of 1 micro-arcsecond to the early stages of the SIM, the technique allows star positions to be measured without first setting up a grid of reference stars; instead, it sets up a reference frame using several reference stars and a target star observed from different locations, and star positions are calculated using delay measurements from separate observations. The narrow angle field was to be used by SIM to detect terrestrial planets; the team applied the same criteria to both the narrow and wide angle measurements. The final requirement before beginning work on flight controls was to make sure that all of the systems developed for the mission worked cohesively; this final NASA technology goal was completed last as it was dependent upon the others.
https://en.wikipedia.org/wiki?curid=570274
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In 1969, Fuller began the Otisco Project, named after its location in Otisco, New York. The project developed and demonstrated concrete spray with mesh-covered wireforms for producing large-scale, load-bearing spanning structures built on-site, without the use of pouring molds, other adjacent surfaces or hoisting. The initial method used a circular concrete footing in which anchor posts were set. Tubes cut to length and with ends flattened were then bolted together to form a duodeca-rhombicahedron (22-sided hemisphere) geodesic structure with spans ranging to . The form was then draped with layers of ¼-inch wire mesh attached by twist ties. Concrete was sprayed onto the structure, building up a solid layer which, when cured, would support additional concrete to be added by a variety of traditional means. Fuller referred to these buildings as monolithic ferroconcrete geodesic domes. However, the tubular frame form proved problematic for setting windows and doors. It was replaced by an iron rebar set vertically in the concrete footing and then bent inward and welded in place to create the dome's wireform structure and performed satisfactorily. Domes up to three stories tall built with this method proved to be remarkably strong. Other shapes such as cones, pyramids and arches proved equally adaptable.
https://en.wikipedia.org/wiki?curid=4031
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A 2014 meta-analysis of sex differences in scholastic achievement published in the journal of "Psychological Bulletin" found females outperformed males in teacher-assigned school marks throughout elementary, junior/middle, high school and at both undergraduate and graduate university level. The meta-analysis done by researchers Daniel Voyer and Susan D. Voyerwas from the University of New Brunswick drew from 97 years of 502 effect sizes and 369 samples stemming from the year 1914 to 2011, and found that the magnitude of higher female performance was not affected by year of publication, thereby contradicted recent claims of "boy crisis" in school achievement. Another 2015 study by researchers Gijsbert Stoet and David C. Geary from the journal of "Intelligence" found that girl's overall education achievement is better in 70 percent of all the 47–75 countries that participated in PISA. The study consisting of 1.5 million 15-year-olds found higher overall female achievement across reading, mathematics, and science literacy and better performance across 70% of participating countries, including many with considerable gaps in economic and political equality, and they fell behind in only 4% of countries. In summary, Stoet and Geary said that sex differences in educational achievement are not reliably linked to gender equality. The results do not prove, however, greater intelligence of women in relation to men.
https://en.wikipedia.org/wiki?curid=16973246
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While the method of chemical characterization of a daughter was successful for flerovium and livermorium, and the simpler structure of even–even nuclei made confirmation of oganesson ("Z" = 118) straightforward, there have been difficulties in establishing the congruence of decay chains from isotopes with odd protons, odd neutrons, or both. To get around this problem with hot fusion, the decay chains from which terminate in spontaneous fission instead of connecting to known nuclei as cold fusion allows, experiments were done in Dubna in 2015 to produce lighter isotopes of flerovium by reaction of Ca with Pu and Pu, particularly Fl, Fl, and Fl; the last had previously been characterized in the Pu(Ca,5n)Fl reaction at Lawrence Berkeley National Laboratory in 2010. Fl was more clearly characterized, while the new isotope Fl was found to undergo immediate spontaneous fission instead of alpha decay to known nuclides around the "N" = 162 shell closure, and Fl was not found. This lightest isotope may yet conceivably be produced in the cold fusion reaction Pb(Ge,n)Fl, which the team at RIKEN in Japan has considered investigating: this reaction is expected to have a higher cross-section of 200 fb than the "world record" low of 30 fb for Bi(Zn,n)Nh, the reaction which RIKEN used for the official discovery of element 113 (nihonium). The Dubna team repeated their investigation of the Pu+Ca reaction in 2017, observing three new consistent decay chains of Fl, another decay chain from this nuclide that may pass through some isomeric states in its daughters, a chain that could be assigned to Fl (likely from Pu impurities in the target), and some spontaneous fissions of which some could be from Fl, though other interpretations including side reactions involving evaporation of charged particles are also possible.
https://en.wikipedia.org/wiki?curid=77473
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In its "2050 Strategy", Kazakhstan gives itself 15 years to evolve into a knowledge economy. New sectors are to be created during each five-year plan. The first of these, covering the years 2010−2014, focused on developing industrial capacity in car manufacturing, aircraft engineering and the production of locomotives, passenger and cargo railroad cars. During the second five-year plan to 2019, the goal is to develop export markets for these products. To enable Kazakhstan to enter the world market of geological exploration, the country intends to increase the efficiency of traditional extractive sectors such as oil and gas. It also intends to develop rare earth metals, given their importance for electronics, laser technology, communication and medical equipment. The second five-year plan coincides with the development of the Business 2020 roadmap for small and medium-sized enterprises (SMEs), which will make provision for the allocation of grants to SMEs in the regions and for microcredit. The government and the National Chamber of Entrepreneurs also plan to develop an effective mechanism for helping start-ups.
https://en.wikipedia.org/wiki?curid=54181703
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While penetration testing concentrates on attacking software and computer systems from the start – scanning ports, examining known defects in protocols and applications running on the system, and patch installations, for example – ethical hacking may include other things. A full-blown ethical hack might include emailing staff to ask for password details, rummaging through executive dustbins and usually breaking, without the knowledge and consent of the targets. Only the owners, CEOs, and Board Members (stakeholders) who asked for such a security review of this magnitude are aware. To try and replicate some of the destructive techniques a real attack might employ, ethical hackers may arrange for cloned test systems, or organize a hack late at night while systems are less critical. In most recent cases these hacks perpetuate for the long-term con (days, if not weeks, of long-term human infiltration into an organization). Some examples include leaving USB/flash key drives with hidden auto-start software in a public area as if someone lost the small drive and an unsuspecting employee found it and took it.
https://en.wikipedia.org/wiki?curid=907240
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The creation of resources such as books which includes mathematical literature, museums, magazines, which can be enjoyed by the public, and which vary according to the historical moment, especially to approach fashions, cultures and to have a greater impact and scope. Education can play a fundamental role in the development of mathematical culture. YouTube channels about mathematics started, such as Numberphile, 3Blue1Brown, and are viewed by many people. Several museums aim at enhancing public understanding of mathematics, like Museum of Mathematics in New York City, and its predecessor, the Goudreau Museum of Mathematics in Art and Science, the Haus der Mathematik in Vienna, the Arithmeum in Bonn, the Mathematisch-Physikalischer Salon in Dresden, the Mathematikum in Giessen, the Experiminta in Frankfurt, the Virtuelles Freiberger Museum für Mathematik und Kunst in Freiberg, or the Garden of Archimedes in Firenze, or the Museu de Matemàtiques de Catalunya in Cornellà de Llobregat. Plus Magazine is a free online magazine run under the Millennium Mathematics Project at the University of Cambridge. In 2012, the appearance of "Quanta Magazine" contributed to mathematical journalism. Several novels, films and books are centered on mathematical subjects and also aim to popularize them, like mathematical fiction. Arguably the first of these is "Flatland", an 1884 novel intended to introduce the reader to the then-recent concepts of the geometry of four-dimensional space; subsequently, authors like Denis Guedj or Apóstolos Doxiádis build some of their plots around Fermat's last theorem or Goldbach's conjecture. Simon Singh wrote Fermat's Last Theorem book, Charles Seife wrote , Rózsa Péter wrote Playing with Infinity.
https://en.wikipedia.org/wiki?curid=2069923
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