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Phenes are the fundamental units of the phenotype that are both unique and elementary to a given level of biological organization. A phene state is the outcome of complex synergistic developmental systems, influenced by genes and gene products, as well as the environment. Root architectural and anatomical phenes determine the temporal and spatial distribution of root foraging in specific soil domains, and therefore affect resource capture. Mobile resources, such as nitrate and water are generally found in deeper soil domains over time due to crop uptake, evaporation, and leaching throughout the growth season. Whereas, immobile soil nutrients, including phosphorus and potassium, are more available in the topsoil. In a heterogenous matrix of soil, plants that are able to acquire edaphic resources at reduced metabolic cost will be favored, as these plants can allocate more resources towards growth, continued soil resource and reproduction.
https://en.wikipedia.org/wiki?curid=63266464
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The mainstay of treatment for infectious tenosynovitis includes symptom relief, antibiotic therapy, and surgery. Early recognition of the disease with early initiation of antibiotics are important for better range of movement of the affected finger. Minimally invasive procedures into the flexor tendon sheath such as catheter irrigation give better outcomes (74% chance of good outcome) when compared to open surgery (26% chance of good outcome). However, wound irrigation with antibiotics has no clear benefits. Most infectious tenosynovitis cases should be managed with tendon sheath irrigation and drainage, with or without debridement of surrounding necrotic tissue, along with treatment with broad-spectrum antibiotics. In severe cases, amputation may even be necessary to prevent the further spread of infection. Following surgical intervention, antibiotic therapy is continued and adjusted based on the results of the fluid culture.
https://en.wikipedia.org/wiki?curid=272541
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Replacing a mechanically scanned array with a fixed AESA mount (such as on the Boeing F/A-18E/F Super Hornet) can help reduce an aircraft's overall radar cross-section (RCS), but some designs (such as the Eurofighter Typhoon) forgo this advantage in order to combine mechanical scanning with electronic scanning and provide a wider angle of total coverage. This high off-nose pointing allows the AESA equipped fighter to employ a Crossing the T maneuver, often referred to as 'beaming' in the context of air-to-air combat, against a mechanically scanned radar that would filter out the low closing speed of the perpendicular flight as ground clutter while the AESA swivels 40 degrees towards the target in order to keep it within the AESA's 60 degree off-angle limit.
https://en.wikipedia.org/wiki?curid=839259
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The rotation of the Earth is somewhat irregular and also is very gradually slowing due to tidal acceleration. Furthermore, the length of the second was determined from observations of the Moon between 1750 and 1890. All of these factors cause the modern mean solar day, on the average, to be slightly longer than the nominal 86,400 SI seconds, the traditional number of seconds per day. As UT is thus slightly irregular in its rate, astronomers introduced Ephemeris Time, which has since been replaced by Terrestrial Time (TT). Because Universal Time is determined by the Earth's rotation, which drifts away from more precise atomic-frequency standards, an adjustment (called a leap second) to this atomic time is needed since () 'broadcast time' remains broadly synchronised with solar time. Thus, the civil broadcast standard for time and frequency usually follows International Atomic Time closely, but occasionally step (or "leap") in order to prevent them from drifting too far from mean solar time.
https://en.wikipedia.org/wiki?curid=41835
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Moreover, these clustered Pcdh genes are predominantly expressed in the developing nervous system and since different subsets of Pcdhs genes are differentially expressed in individual neurons, a vast cell surface diversity may arise from this combinatorial expression. This has led to speculation and further to the proposal that Pcdhs may provide a synaptic-address code for neuronal connectivity or a single-cell barcode for self-recognition/self-avoidance similar to that ascribed to DSCAM proteins of invertebrates. Although vertebrate DSCAMs lack the diversity of their invertebrate counterparts, the selective transcription of individual Pcdh isoforms can be achieved by promoter choice followed by alternative pre-mRNA cis-splicing thus increasing the number of possible combinations.
https://en.wikipedia.org/wiki?curid=9919262
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Intel introduced the first microprocessor, the 4004, in 1971, a special computer chip that could be sent a simple instruction and provide its result. This allowed the ability to create software programs around the microprocessor rather than fix the logic into circuits and ICs. Engineers at both Atari, Inc. (via its Cyan Engineering subsidiary) and at Alpex Computer Corporation saw the potential to apply this to home consoles as prices for microprocessors became more affordable. Alpex's work led to partnership with semiconductor manufacturer Fairchild Camera and Instrument and lead to the release of the first such programmable home console, the Fairchild Channel F released in 1976, based on the Fairchild F8 microprocessor. The Channel F also established the use of ROM cartridges to provide the software for the programmable console, consisting of a ROM chip mounted on a circuit board within a hard casing that can withstand the physical insertion into the console and potential static electricity buildup. Atari's own programmable console, the Atari Video Computer System (Atari VCS or later known as the Atari 2600), was released in 1977 and based on the MOS Technology 6507 microprocessor, with a cartridge design influenced in part by the Channel F system. Other console manufacturers soon followed suit with the production of their own programmable consoles.
https://en.wikipedia.org/wiki?curid=3442219
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April 4 also saw the announcement of two new downloadable content packs for the coming weeks: an "Orrery" quest that would see players set out to repair a Dwarven Orrery; and a "Wizard's Tower" that would offer a new home for player characters, complete with the capacity to grow herbs, summon atronachs, and make spells. 1UP predicted that, given Bethesda's response to customer criticism, those releases would be somewhat more substantial than the "Horse Armor" release was. On April 7, Bethesda priced the "Orrery". Offering what GameSpot called "more bang for less buck", Bethesda set the PC release price at US$1.89, and the Xbox 360 release price at 150 Marketplace points, equivalent to US$1.88. Joystiq offered their support—Big ups—to the company for the new price. "Although we passed on the $2.50 horse armor this week, we'll definitely be messin' with that Orrery device when it hits the Marketplace." The pack was eventually released on April 17. Also on April 7, EB Games and GameStop began offering a coupon promising one free download of the "Horse Armor" pack with every purchase of the PC edition of "Oblivion". The "Wizard's Tower", called the "Frostcrag Spire" in-game, was released on April 24 for the same price as the "Orrery".
https://en.wikipedia.org/wiki?curid=12164267
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In addition to his basic genetic research and scientific leadership, Collins is known for his close attention to ethical and legal issues in genetics. He has been a strong advocate for protecting the privacy of genetic information and has served as a national leader in securing the passage of the federal Genetic Information and Nondiscrimination Act, which prohibits gene-based discrimination in employment and health insurance. In 2013, spurred by concerns over the publication of the genome of the widely used HeLa cell line derived from the late Henrietta Lacks, Collins and other NIH leaders worked with the Lacks family to reach an agreement to protect their privacy, while giving researchers controlled access to the genomic data.
https://en.wikipedia.org/wiki?curid=23943084
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Various competing schools of thought exist in the field. Some are close to resource and environmental economics while others are far more heterodox in outlook. An example of the latter is the "European Society for Ecological Economics". An example of the former is the Swedish "Beijer International Institute of Ecological Economics." Clive Spash has argued for the classification of the ecological economics movement, and more generally work by different economic schools on the environment, into three main categories. These are the mainstream new resource economists, the new environmental pragmatists, and the more radical social ecological economists. International survey work comparing the relevance of the categories for mainstream and heterodox economists shows some clear divisions between environmental and ecological economists. A growing field of radical social-ecological theory is degrowth economics. Degrowth addresses both biophysical limits and global inequality while rejecting neoliberal economics. Degrowth prioritizes grassroots initiatives in progressive socio-ecological goals, adhering to ecological limits by shrinking the human ecological footprint (See Differences from Mainstream Economics Below). It involves an equitable downscale in both production and consumption of resources in order to adhere to biophysical limits. Degrowth draws from Marxian economics, citing the growth of efficient systems as the alienation of nature and man. Economic movements like degrowth reject the idea of growth itself. Some degrowth theorists call for an "exit of the economy". Critics of the degrowth movement include new resource economists, who point to the gaining momentum of sustainable development. These economists highlight the positive aspects of a green economy, which include equitable access to renewable energy and a commitment to eradicate global inequality through sustainable development (See Green Economics). Examples of heterodox ecological economic experiments include the Catalan Integral Cooperative and the Solidarity Economy Networks in Italy. Both of these grassroots movements use communitarian based economies and consciously reduce their ecological footprint by limiting material growth and adapting to regenerative agriculture.
https://en.wikipedia.org/wiki?curid=177694
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In 1978 The Swedish team of Siporex Sweden opened the Siporex Factory in the Kingdom of Saudi Arabia - the "Lightweight Construction Company - Siporex - LCC SIPOREX" which have supplied the Middle-East and Africa and Japan by most of its need. The LCC Siporex Factory has operated for more than 40 years. Today aerated concrete is produced by many companies, particularly in Europe and Asia. There is some production in the Americas and in Africa, there is one plant in Egypt. AAC production in Europe has slowed down considerably, but the industry is growing rapidly in Asia due to strong demand in housing and commercial space. China is now the largest aircrete market in the world with several hundred factories. China, Central Asia, India, and the Middle-East are the biggest in terms of AAC manufacturing and consumption.
https://en.wikipedia.org/wiki?curid=2624245
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For the next century, molybdenum had no industrial use. It was relatively scarce, the pure metal was difficult to extract, and the necessary techniques of metallurgy were immature. Early molybdenum steel alloys showed great promise of increased hardness, but efforts to manufacture the alloys on a large scale were hampered with inconsistent results, a tendency toward brittleness, and recrystallization. In 1906, William D. Coolidge filed a patent for rendering molybdenum ductile, leading to applications as a heating element for high-temperature furnaces and as a support for tungsten-filament light bulbs; oxide formation and degradation require that molybdenum be physically sealed or held in an inert gas. In 1913, Frank E. Elmore developed a froth flotation process to recover molybdenite from ores; flotation remains the primary isolation process.
https://en.wikipedia.org/wiki?curid=19052
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The introduction of logic synthesis for HDLs pushed HDLs from the background into the foreground of digital design. Synthesis tools compiled HDL source files (written in a constrained format called RTL) into a manufacturable netlist description in terms of gates and transistors. Writing synthesizable RTL files required practice and discipline on the part of the designer; compared to a traditional schematic layout, synthesized RTL netlists were almost always larger in area and slower in performance. A circuit design from a skilled engineer, using labor-intensive schematic-capture/hand-layout, would almost always outperform its logically-synthesized equivalent, but the productivity advantage held by synthesis soon displaced digital schematic capture to exactly those areas that were problematic for RTL synthesis: extremely high-speed, low-power, or asynchronous circuitry.
https://en.wikipedia.org/wiki?curid=74554
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"Combining a monadic theory with a first order theory:" Feferman–Vaught theorem extends/applies as follows. If "M" is an MSO model and "N" is a first order model, then "M" remains decidable relative to a (Theory("M"), Theory("N")) oracle even if "M" is augmented with all functions "M"→"N" where "M" is identified with its first objects, and for each "s"∈"M" we use a disjoint copy of "N", with the language modified accordingly. For example, if "N" is (formula_1,0,+,⋅), we can state ∀(function "f") ∀"s" ∃"r"∈"N" "f"("s") + "r" = 0. If "M" is S2S (or more generally, the tree counterpart of some monadic model), the automata can now use "N"-formulas, and thereby convert "f":"M"→"N" into a tuple of "M" sets. Disjointness is necessary as otherwise for every infinite "N" with equality, the extended S2S or just WS1S is undecidable. Also, for a (possibly incomplete) theory "T", the theory "T" of "M"-products of "T" is decidable relative to a (Theory("M"), "T") oracle, where a model of "T" uses an arbitrary disjoint model "N" of "T" for each "s"∈"M" (as above, "M" is an MSO model; Theory("N") may depend on "s"). The proof is by induction on formula complexity. Let "v" be the list of free "N" variables, including "f"("s") if function "f" is free. By induction, one shows that "v" is only used through a finite set of "N"-formulas with |"v"| free variables. Thus, we can quantify over all possible outcomes by using "N" (or "T") to answer what is possible, and given a list possibilities (or constraints), formulate a corresponding sentence in "M".
https://en.wikipedia.org/wiki?curid=72252525
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The Lower Elwha Klallam Tribe had sought the removal of the two dams since they were built. In 1968 the owner of the dams, Crown Zellerbach Corporation, applied to the Federal Energy Regulatory Commission (FERC) for a license for Elwha Dam, and in 1973 applied to renew the license for Glines Canyon Dam. By this time, the treaty fishing rights of the Pacific Northwest tribes had been recognized in the 1979 Boldt Decision, and the Lower Elwha Klallam Tribe pressed for removal of the dams to restore salmon runs to the Elwha River. The Tribe opposed both applications by Crown Zellerbach, intervening before the FERC. The environmental community also got involved in opposing the dams. By the 1980s twelve conservation groups opposed the relicensing process, including Olympic Park Associates, Seattle Audubon Society, Sierra Club, Friends of the Earth, and American Rivers.
https://en.wikipedia.org/wiki?curid=19291947
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From the birth of their science, biologists have sought to explain apparent regularities in observational data. In his biology, Aristotle inferred rules governing differences between live-bearing tetrapods (in modern terms, terrestrial placental mammals). Among his rules were that brood size decreases with adult body mass, while lifespan increases with gestation period and with body mass, and fecundity decreases with lifespan. Thus, for example, elephants have smaller and fewer broods than mice, but longer lifespan and gestation. Rules like these concisely organized the sum of knowledge obtained by early scientific measurements of the natural world, and could be used as models to predict future observations. Among the earliest biological rules in modern times are those of Karl Ernst von Baer (from 1828 onwards) on embryonic development, and of Constantin Wilhelm Lambert Gloger on animal pigmentation, in 1833.
https://en.wikipedia.org/wiki?curid=50550012
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"Tunny" was originally commissioned in September 1942 as a fleet submarine, and undertook a total of nine wartime patrols in the Pacific during the Second World War, for which she was awarded two Distinguished Unit Citations, before being decommissioned in December 1945. The boat was recommissioned into reserve in February 1952 as a stand-by for service during the Korean War, before decommissioning again in April. "Tunny" returned to service for a third time in March 1953 for conversion into a guided missile submarine, to be fitted with the missile hangar and launcher for Regulus. From 1953 to 1957, the boat was stationed at Port Hueneme as part of the Regulus test program, before transferring to Pearl Harbor to bring the missile into operational service. Following the withdrawal of Regulus, "Tunny" was converted into a troop-carrying submarine to conduct special operations off the coast of Vietnam. "Tunny" was decommissioned for the final time in June 1969, and was expended as a target in June 1970.
https://en.wikipedia.org/wiki?curid=59895854
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Nitisinone is prescribed ultimately to reduce the accumulation of toxic metabolic intermediates, such as succinylacetate, which are toxic to cells. It modifies the function of 4-hydrooxyphenylpyruvate dioxygenase by acting as a competitive inhibitor. 4-hydrooxyphenylpyruvate dioxygenase functions to convert 4-hydroxyphenylpyruvate to homogentisate as the second enzymatic reaction in the tyrosine catabolic pathway. This prevents the further catabolism of tyrosine. It is recommended that nitisinone treatment begins immediately following a confirmed or suspected case of HT1. It is supplied orally as a capsule or suspension in dose increments of 2 mg, 5 mg, 10 mg, or 20 mg or 4 mg/mL respectively. The starting dose is 1 mg/kg one time daily or 2 mg/kg one time daily for 48 hours if the patient is experiencing acute liver failure. Patient responsiveness to nitisinone is assessed by measuring blood coagulation activity and SA levels in blood and urine. Patients should display a positive response within 24–48 hours of first dose. Establishment of the long-term dosage will vary from patient to patient. It is recommended that nitisinone levels be maintained at 30-50 μM in the blood stream.
https://en.wikipedia.org/wiki?curid=63823206
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Alkenones are long-chain unsaturated methyl and ethyl "n"-ketones produced by a few phytoplankton species of the class Prymnesiophyceae. Alkenones typically contain between 35 and 41 carbon atoms and with between two and four double bonds. Uniquely for biolipids, alkenones have a spacing of five methylene groups between double bonds, which are of the less common E configuration. The biological function of alkenones remains under debate although it is likely that they are storage lipids. Alkenones were first described in ocean sediments recovered from Walvis Ridge and then shortly afterwards in cultures of the marine coccolithophore "Emiliania huxleyi". The earliest known occurrence of alkenones is during the Aptian 120 million years ago. They are used in organic geochemistry as a proxy for past sea surface temperature.
https://en.wikipedia.org/wiki?curid=4299233
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New York City Police Commissioner Julius Enderby is secretly a member of the Medievalists, a subversive anti-robot group which pines for the 'olden days' where men did not live in the 'caves of steel'. He uses his position to engineer meetings with Spacer Dr. Sarton under the guise of further cooperation, but he actually intends to destroy R. Daneel - who lives with and resembles Dr. Sarton. Enderby orders R. Sammy to bring a blaster through the unmonitored 'open air' (something that no Earthman could countenance), but in the heat of the moment Enderby drops his glasses and fails to distinguish between the human and robot, accidentally shooting the human. Knowing that Baley's wife is also a Medievalist, he assigns Baley to the case, working with R. Daneel who represents the Spacers, and spreads a rumour about humanoid robots amongst the subversives to throw suspicion on Baley when Enderby later destroys R. Sammy with radiation. Daneel rules out Enderby as the murderer as his brain patterns show him incapable of deliberately killing.
https://en.wikipedia.org/wiki?curid=60129
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Guided by similar motivations as his former partner, Foucault in 1850 was more interested in settling the particle-versus-wave debate than in determining an accurate absolute value for the speed of light. Foucault measured the differential speed of light through air versus water by inserting a tube filled with water between the rotating mirror and the distant mirror. His experimental results, announced shortly before Fizeau announced his results on the same topic, were viewed as "driving the last nail in the coffin" of Newton's corpuscle theory of light when it showed that light travels more slowly through water than through air. Newton had explained refraction as a "pull" of the medium upon the light, implying an increased speed of light in the medium. The corpuscular theory of light went into abeyance, completely overshadowed by wave theory. This state of affairs lasted until 1905, when Einstein presented heuristic arguments that under various circumstances, such as when considering the photoelectric effect, light exhibits behaviors indicative of a particle nature.
https://en.wikipedia.org/wiki?curid=148819
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Grotzinger has made major contributions to the fields of Geobiology and Paleontology. Beginning in 1993, Grotzinger and his colleagues began a research program aimed at understanding the chronology of major biological and environmental events leading up to, and perhaps driving early Cambrian radiation of metazoans. The so-called Cambrian explosion of biodiversity was shown to have been much more rapid than previously understood. It also may have followed an extinction event of earlier organisms that pioneered and experimented with calcification. More recent research over the past decade has been based on understanding carbon and sulfur isotope ratios in carbonate sediments of Ediacaran age. This work proposed that vertical circulation of ocean water led to oxygenation of the deep ocean shortly before the end of the Proterozoic time, which may also have contributed to the rise in biodiversity in early Cambrian time.
https://en.wikipedia.org/wiki?curid=26158825
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The countdown for the test started at 2:00 am (IST) on 5 July 2018. At 7:00 am (IST) The Crew Escape System with crew module successfully lifted-off from Satish Dhawan Space Centre. The crew module was accelerated to 10 g and reached a highest altitude of , it later safely parachuted down and floated in the Bay of Bengal away from its launch site. It was carried skyward using seven solid-fueled rocket motors keeping within the safe g-force limits. Later recovery boats were sent to recover the crew module. The total duration of the test mission was 259 seconds. The test launch process was recorded by around 300 sensors. Main objectives of test were nominal 20 second ascent and 200 seconds of descent, not including the splashdown. Chute detachment was a scheduled event occurring around 259.4 seconds after launch as intended.
https://en.wikipedia.org/wiki?curid=51777865
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Another error in the supervisory attentional system can lead to more devastating implications. When humans are faced with a threatening situation there is often limited time to generate the fight-or-flight response ideally suited to increase survival. Cognitive paralysis is when an individual fails to respond or 'freezes' during an emergency because of either a temporal or cognitive deficiency. The inhibition of the SAS is the proposed temporal constraint during an emergency. If an appropriate pre-learned schema is retrievable, then a survival response will be initiated. However, if no existing schemata can respond, the result is cognitive paralysis, otherwise exhibiting irrational behaviour. Based on this understanding, one may wrongly speculate that the SAS is unfavourable in dangerous situations. The supervisory attentional system provides individuals with the ability to predict and prepare for situations mentally prior to any possible encounter. Many have argued about the specific roles of the SAS in survival situations; a general understanding is that it functions to increase the chance of survival and that it operates in conjunction with an integrated system.
https://en.wikipedia.org/wiki?curid=34820690
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CBI conducted measurements at frequencies between 26 and 36 GHz in ten bands of 1 GHz bandwidth. It had a resolution of better than 1/10 of a degree. (In comparison, the pioneering COBE satellite, which produced the first detection of fluctuations in the microwave background in 1992, had a resolution of about 7 degrees.) Among the key findings of the CBI is the fact that fluctuations which have a small size on the sky are weaker than fluctuations which have a large size on the sky, which confirmed earlier theoretical predictions. More technically, CBI was the first experiment to detect intrinsic anisotropy in the microwave background on mass scales of galaxy clusters; it provided the first detection of the Silk damping tail; it found a hint of excess power at high-l multipoles (CBI-excess) than expected from the ΛCDM model; and it detected fluctuations in the polarization of the microwave background obtaining the first detailed E-mode polarization spectrum providing evidence that it is out of phase with the total intensity mode spectrum.
https://en.wikipedia.org/wiki?curid=1115236
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Toxic chemicals are sometimes produced in the process. Sulfuric acid and H ions that have been formed can leak into the ground and surface water turning it acidic, causing environmental damage. Heavy ions such as iron, zinc, and arsenic leak during acid mine drainage. When the pH of this solution rises, as a result of dilution by fresh water, these ions precipitate, forming "Yellow Boy" pollution. For these reasons, a setup of bioleaching must be carefully planned, since the process can lead to a biosafety failure. Unlike other methods, once started, bioheap leaching cannot be quickly stopped, because leaching would still continue with rainwater and natural bacteria. Projects like Finnish Talvivaara proved to be environmentally and economically disastrous.
https://en.wikipedia.org/wiki?curid=4111
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Just before the Second World War, the American naval historian (and science fiction author) Fletcher Pratt published a book on naval wargaming as could be done by civilians using ship models cut off at the waterline to be moved on the floors of basketball courts and similar locales. The scale he used was non-standard (reported as 1:666), and may have been influenced by toy ships then available, but as the hobby progressed, and other rule sets came into use, it was progressively supplemented by the series 1:600, 1:1200, and 1:2400. In Britain, 1:3000 became popular and these models also have come into use in the USA. These had the advantage of approximating the nautical mile as 120 inches, 60 inches, and 30 inches, respectively. As the knot is based on this mile and a 60-minute hour, this was quite handy.
https://en.wikipedia.org/wiki?curid=297672
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The state of the universe, as it is, does not violate the CPT symmetry, because the Big Bang could be considered as a double sided event, both classically and quantum mechanically, consisting of a universe-antiuniverse pair. This means that this universe is the charge (C), parity (P) and time (T) image of the anti-universe. This pair emerged from the Big Bang epochs not directly into a hot, radiation-dominated era. The antiuniverse would flow back in time from the Big Bang, becoming bigger as it does so, and would be also dominated by antimatter. Its spatial properties are inverted if compared to those in our universe, a situation analogous to creating electron–positron pairs in a vacuum. This model, devised by physicists from the Perimeter Institute for Theoretical Physics in Canada, proposes that temperature fluctuations in the cosmic microwave background (CMB) are due to the quantum-mechanical nature of space-time near the Big Bang singularity. This means that a point in the future of our universe and a point in the distant past of the antiuniverse would provide fixed classical points, while all possible quantum-based permutations would exist in between. Quantum uncertainty causes the universe and antiuniverse to not be exact mirror images of each other.
https://en.wikipedia.org/wiki?curid=2223114
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These complex optical systems started out as the multicellular eyepatch gradually depressed into a cup, which first granted the ability to discriminate brightness in directions, then in finer and finer directions as the pit deepened. While flat eyepatches were ineffective at determining the direction of light, as a beam of light would activate exactly the same patch of photo-sensitive cells regardless of its direction, the "cup" shape of the pit eyes allowed limited directional differentiation by changing which cells the lights would hit depending upon the light's angle. Pit eyes, which had arisen by the Cambrian period, were seen in ancient snails, and are found in some snails and other invertebrates living today, such as planaria. Planaria can slightly differentiate the direction and intensity of light because of their cup-shaped, heavily pigmented retina cells, which shield the light-sensitive cells from exposure in all directions except for the single opening for the light. However, this proto-eye is still much more useful for detecting the absence or presence of light than its direction; this gradually changes as the eye's pit deepens and the number of photoreceptive cells grows, allowing for increasingly precise visual information.
https://en.wikipedia.org/wiki?curid=5645086
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The synthesis of ring II was accomplished with a Fischer indole synthesis using phenylhydrazine 1 and acetophenone derivative acetoveratrone 2 (catalyst polyphosphoric acid) to give the 2-veratrylindole 3. The veratryl group not only blocks the 2-position for further electrophilic substitution but will also become part of the strychnine skeleton. A Mannich reaction with formaldehyde and dimethylamine) produced gramine 4. Alkylation with iodomethane gave an intermediate quaternary ammonium salt which reacted with sodium cyanide in a nucleophilic substitution to nitrile 5 and then in a reduction with lithium aluminium hydride to tryptamine 6. Amine-carbonyl condensation with ethyl glyoxylate give the imine 7. The reaction of this imine with TsCl in pyridine to the ring-closed N-tosyl compound 8 was described by Woodward as a concerted nucleophilic enamine attack and formally a Pictet–Spengler reaction. This compound should form as a diastereomeric pair but only one compound was found although which one was not investigated. Finally the newly formed double bond was reduced by sodium borohydride to indoline 9 with the C8 hydrogen atom approaching from the least hindered side (this proton is removed later on in the sequence and is of no importance).
https://en.wikipedia.org/wiki?curid=23960205
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This article discusses aircraft carrier operations during World War II. Naval historians such as Evan Mawdsley, Richard Overy, and Craig Symonds concluded that World War II's decisive victories on land could not have been won without decisive victories at sea. Naval battles to keep shipping lanes open for combatant's movement of troops, guns, ammunition, tanks, warships, aircraft, raw materials, and food largely determined the outcome of land battles. Without the Allied victory in keeping shipping lanes open during the Battle of the Atlantic, Britain could not have fed her people or withstood Axis offensives in Europe and North Africa. Without Britain's survival and without Allied shipments of food and industrial equipment to the Soviet Union, her military and economic power would likely not have rebounded in time for Russian soldiers to prevail at Stalingrad and Kursk.
https://en.wikipedia.org/wiki?curid=65453048
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Thomas's recent work has focused on the in-depth understanding of chromatin proteins, such as high-mobility group box 1 protein (HMGB1) and histone H1, and their interactions with DNA. In 2007, her research team used NMR mapping to better define the negative regulation of the HMGB1-DNA interaction that was suspected to be largely controlled by the acidic tail of HMGB1. They found that regardless of the length of the acidic tail, it makes extensive contacts with the DNA-binding regions of the two tandem HMG-boxes in HMGB1. A year later, she published a paper describing the opposing effects of H1 and HMGB1 on the nucleosome. Histone H1 was shown to stabilize the structure by winding two turns of linker DNA around the octamer while HMGB1 destabilized the nucleosome by bending adjacent DNA. NMR spectroscopy was again used to show that H1 binds to the acidic tail of HMGB1 via its basic C-terminus, thus halting the HMGB1-DNA interaction. She later described the structure of these interactions as collapsed and sandwich-like, suggesting that it is important for the dynamic activity of the DNA-binding proteins.
https://en.wikipedia.org/wiki?curid=11568677
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Folate targeting is a method utilized in biotechnology for drug delivery purposes. This Trojan Horse process, which was created by Drs. Christopher P. Leamon and Philip S. Low, involves the attachment of the vitamin, folate (folic acid), to a molecule/drug to form a "folate conjugate". Based on the natural high affinity of folate for the folate receptor protein (FR), which is commonly expressed on the surface of many human cancers, folate-drug conjugates also bind tightly to the FR and trigger cellular uptake via endocytosis. Molecules as diverse as small radiodiagnostic imaging agents to large DNA plasmid formulations have successfully been delivered inside FR-positive cells and tissues.
https://en.wikipedia.org/wiki?curid=24801892
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According to Marx, wages and salaries are considered as the price of labour power, related to working hours or outputs produced by the labour force. At the company level, an employee does not control and own the means of production in a capitalist mode of production. Instead, an employee is performing specific duties under a contract of employment, working for wages or salaries. As for firms and profit-seeking organizations, from a personnel economics perspective, to maximize efficiency and productivity there must be an equilibrium between labour markets and product markets. In human resource practices, compensation structure tend to shift towards pay-for-performance bonus or incentive pay rather than base salary to attract the right workers, even if conflicts of interest exist in an employer-worker relationship.
https://en.wikipedia.org/wiki?curid=47155
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The college has a central library and separate reference libraries for MBA and MCA. The central library operates in a three-storeyed building where separate reference and stack rooms are provided. The libraries are fully automated with more than 62,000 volumes of textbooks and reference books in over 15,350 titles. 213 technical journals, 45 IEEE publications, and 57 magazines are subscribed to. Digital collections include more than 3000 DVDs and CD-ROMs. The Online Public Access Catalogue (OPAC) is a part of FISAT INTRANET, which enables the members to search for, reserve or check the status of any book in the library from anywhere in the world through the FISAT website. E-journal subscriptions include IEL Online, ASME, McGraw Hill-Access Engineering, Springer Link, J-Gate (JET & JSMS), ASTM Digital Library, Proquest and Elsevier-Science Direct.
https://en.wikipedia.org/wiki?curid=12523740
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As a result, when light propagates through the cleavage plane and transits to free space from within the semiconductor crystal, a fraction of the light energy is absorbed by the surface states where it is converted to heat by phonon-electron interactions. This heats the cleaved mirror. In addition, the mirror may heat simply because the edge of the diode laser—which is electrically pumped—is in less-than-perfect contact with the mount that provides a path for heat removal. The heating of the mirror causes the bandgap of the semiconductor to shrink in the warmer areas. The bandgap shrinkage brings more electronic band-to-band transitions into alignment with the photon energy causing yet more absorption. This is thermal runaway, a form of positive feedback, and the result can be melting of the facet, known as "catastrophic optical damage", or COD.
https://en.wikipedia.org/wiki?curid=142258
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A "stipe" is a stalk or stemlike structure present in an alga. It may grow as a short structure near the base of the alga (as in "Laminaria"), or it may develop into a large, complex structure running throughout the algal body (as in "Sargassum" or "Macrocystis"). In the most structurally differentiated brown algae (such as "Fucus"), the tissues within the stipe are divided into three distinct layers or regions. These regions include a central pith, a surrounding cortex, and an outer epidermis, each of which has an analog in the stem of a vascular plant. In some brown algae, the pith region includes a core of elongated cells that resemble the phloem of vascular plants both in structure and function. In others (such as "Nereocystis"), the center of the stipe is hollow and filled with gas that serves to keep that part of the alga buoyant. The stipe may be relatively flexible and elastic in species like "Macrocystis pyrifera" that grow in strong currents, or may be more rigid in species like "Postelsia palmaeformis" that are exposed to the atmosphere at low tide.
https://en.wikipedia.org/wiki?curid=233271
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His most important works are in fields of computational materials discovery, in particular the effects of pressure on chemical bonding, and state of matter at extreme conditions (e.g. inside the Earth and other planets). He has developed novel and highly efficient methods of crystal structure prediction that became basis of the USPEX code, used by more than 8500 researchers worldwide. Among the highlights are the discovery of the structure of a superhard phase of boron, gamma-B, transparent phase of sodium, new carbon allotrope, prediction of MgSiO3 post-perovskite and its stability in the Earth's mantle, prediction of other planet-forming minerals, prediction and synthesis of "forbidden" compounds (e.g., Na3Cl), discovery of helium chemistry, and creation of borophene - a 2D-monolayer of boron atoms, with great promises for future technologies. Oganov has proposed a new scale of electronegativities of the chemical elements.
https://en.wikipedia.org/wiki?curid=45353173
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Determining whether Meshulam's bound can be improved to formula_17 with formula_14 was considered one of the most intriguing open problems in additive combinatorics and Ramsey theory for over 20 years, highlighted, for instance, by blog posts on this problem from Fields medalists Timothy Gowers and Terence Tao. In his blog post, Tao refers to it as "perhaps, my favorite open problem" and gives a simplified proof of the exponential bound on cap sets, namely that for any prime power formula_23, a subset formula_24 that contains no arithmetic progression of length formula_25 has size at most formula_26 for some formula_27 with a positive constant formula_28. The cap set conjecture was solved in 2016, when Ernie Croot, Vsevolod Lev, and Péter Pál Pach posted a preprint on a tightly related problem (same problem but on formula_29), that was quickly used by Jordan Ellenberg and Dion Gijswijt to prove an upper bound of formula_30 on the cap set problem. In 2019, Sander Dahmen, Johannes Hölzl and Rob Lewis formalised the proof of this upper bound in the Lean theorem prover.
https://en.wikipedia.org/wiki?curid=51223601
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Newer technologies have increased the options for citizen science. Citizen scientists can build and operate their own instruments to gather data for their own experiments or as part of a larger project. Examples include amateur radio, amateur astronomy, Six Sigma Projects, and Maker activities. Scientist Joshua Pearce has advocated for the creation of open-source hardware based scientific equipment that both citizen scientists and professional scientists, which can be replicated by digital manufacturing techniques such as 3D printing. Multiple studies have shown this approach radically reduces scientific equipment costs. Examples of this approach include water testing, nitrate and other environmental testing, basic biology and optics. Groups such as Public Lab, which is a community where citizen scientists can learn how to investigate environmental concerns using inexpensive DIY techniques, embody this approach.
https://en.wikipedia.org/wiki?curid=2155752
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To enable it to probe the depths, 15 of "Challenger" 17 guns were removed and its spars reduced to make more space available. Laboratories, extra cabins and a special dredging platform were installed. "Challenger" used mainly sail power during the expedition; the steam engine was used only for dragging the dredge, station-keeping while taking soundings, and entering and leaving ports. It was loaded with specimen jars, filled with alcohol for preservation of samples, microscopes and chemical apparatus, trawls and dredges, thermometers, barometers, water sampling bottles, sounding leads, devices to collect sediment from the sea bed and great lengths of rope with which to suspend the equipment into the ocean depths.
https://en.wikipedia.org/wiki?curid=88284
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Another response to the regress problem is coherentism, which is the rejection of the assumption that the regress proceeds according to a pattern of linear justification. To avoid the charge of circularity, coherentists hold that an individual belief is justified circularly by the way it fits together (coheres) with the rest of the belief system of which it is a part. This theory has the advantage of avoiding the infinite regress without claiming special, possibly arbitrary status for some particular class of beliefs. Yet, since a system can be coherent while also being wrong, coherentists face the difficulty of ensuring that the whole system corresponds to reality. Additionally, most logicians agree that any argument that is circular is, at best, only trivially valid. That is, to be illuminating, arguments must operate with information from multiple premises, not simply conclude by reiterating a premise.
https://en.wikipedia.org/wiki?curid=9247
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The .NET Micro Framework (NETMF) is a .NET Framework platform for resource-constrained devices with at least 512 kB of flash and 256 kB of random-access memory (RAM). It includes a small version of the .NET Common Language Runtime (CLR) and supports development in C#, Visual Basic .NET, and debugging (in an emulator or on hardware) using Microsoft Visual Studio. NETMF features a subset of the .NET base class libraries (about 70 classes with about 420 methods), an implementation of Windows Communication Foundation (WCF), a GUI framework loosely based on Windows Presentation Foundation (WPF), and a Web Services stack based on Simple Object Access Protocol (SOAP) and Web Services Description Language (WSDL). NETMF also features added libraries specific to embedded applications. It is free and open-source software released under Apache License 2.0.
https://en.wikipedia.org/wiki?curid=6919166
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Trinidad and Tobago competed at the 2012 Summer Olympics in London, United Kingdom from 27 July to 12 August 2012. This was Trinidad and Tobago's most successful Summer Olympics. It was the nation's largest ever delegation sent to the Olympics, with a total of 30 athletes, 21 men and 9 women, in 6 sports. Trinidad and Tobago's participation in these games marked its sixteenth Olympic appearance as an independent nation, although it had previously competed in four other games (including the 1948 debut in the same host city London) as a British colony, and as part of the West Indies Federation. The nation was awarded four Olympic medals based on the efforts by the athletes who competed in the track and field. Javelin thrower Keshorn Walcott became the first Trinidadian athlete to win an Olympic gold medal since the 1976 Summer Olympics in Montreal, where Hasely Crawford won for the sprint event. Marc Burns, a four-time Olympic athlete and a relay sprinter who led his team by winning the silver medal in Beijing, was the nation's flag bearer at the opening ceremony.
https://en.wikipedia.org/wiki?curid=31969474
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NIOSH has funded ten Centers of Excellence for Total Worker Health in the United States to explore and research concepts of TWH, such as pilot testing policies and programs, building a scientific evidence base developing new solutions, developing and disseminating best practices and tool kits, developing strategies for overcoming barriers to organizational adoption, and applying physiological and biological markers of stress, sleep, and depression. The ten NIOSH Centers of Excellence for "Total Worker Health" are at the University of California San Francisco, University of Colorado School of Public Health, University of Massachusetts Lowell and University of Connecticut jointly, Harvard-T.H. Chan School of Public Health, University of Iowa, Johns Hopkins University, Oregon Institute of Occupational Health Science, University of Illinois-Chicago, University of North Carolina at Chapel Hill, and University of Utah School of Medicine.
https://en.wikipedia.org/wiki?curid=37423001
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The album's concept is similar to their previous "Ummagumma" album, in that it features the full band in the first half, and focuses on individual members in the second half. Side two opens with three five-minute songs: one by each of the band's three resident songwriters, and closes with a suite with sound effects primarily conceived by Mason, but credited to the whole group. Waters contributes a folk ballad called "If", playing acoustic guitar. Pink Floyd rarely played the song live, but Waters often performed it at solo shows in support of his "Radio K.A.O.S." album, more than a decade later. This is followed by Wright's "Summer '68", which also features prominent use of brass in places. It was issued as a Japanese single in 1971, and was the only track on the album never to be played live in concert. The song was reportedly about Wright and a groupie on tour, and had the working title of "One Night Stand".
https://en.wikipedia.org/wiki?curid=271068
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A single-electrode voltage clamp — discontinuous, or SEVC-d, has some advantages over SEVC-c for whole-cell recording. In this, a different approach is taken for passing current and recording voltage. A SEVC-d amplifier operates on a "time-sharing" basis, so the electrode regularly and frequently switches between passing current and measuring voltage. In effect, there are two electrodes, but each is in operation for only half of the time it is on. The oscillation between the two functions of the single electrode is termed a duty cycle. During each cycle, the amplifier measures the membrane potential and compares it with the holding potential. An operational amplifier measures the difference, and generates an error signal. This current is a mirror image of the current generated by the cell. The amplifier outputs feature sample and hold circuits, so each briefly sampled voltage is then held on the output until the next measurement in the next cycle. To be specific, the amplifier measures voltage in the first few microseconds of the cycle, generates the error signal, and spends the rest of the cycle passing current to reduce that error. At the start of the next cycle, voltage is measured again, a new error signal generated, current passed etc. The experimenter sets the cycle length, and it is possible to sample with periods as low as about 15 microseconds, corresponding to a 67 kHz switching frequency. Switching frequencies lower than about 10 kHz are not sufficient when working with action potentials that are less than 1 millisecond wide. Note that not all discontinuous voltage-clamp amplifier support switching frequencies higher than 10 kHz.
https://en.wikipedia.org/wiki?curid=603690
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A seed bank (also seed banks or seeds bank) stores seeds to preserve genetic diversity; hence it is a type of gene bank. There are many reasons to store seeds. One is to preserve the genes that plant breeders need to increase yield, disease resistance, drought tolerance, nutritional quality, taste, etc. of crops. Another is to forestall loss of genetic diversity in rare or imperiled plant species in an effort to conserve biodiversity ex situ. Many plants that were used centuries ago by humans are used less frequently now; seed banks offer a way to preserve that historical and cultural value. Collections of seeds stored at constant low temperature and low moisture are guarded against loss of genetic resources that are otherwise maintained in situ or in field collections. These alternative "living" collections can be damaged by natural disasters, outbreaks of disease, or war. Seed banks are considered seed libraries, containing valuable information about evolved strategies to combat plant stress, and can be used to create genetically modified versions of existing seeds. The work of seed banks often span decades and even centuries. Most seed banks are publicly funded and seeds are usually available for research that benefits the public.
https://en.wikipedia.org/wiki?curid=142181
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Though, as of recent in the year 2020 during the height of the COVID-19 Pandemic. The ethical atmosphere regarding public health surveillance began to take center stage due to its overall use during the height of the pandemic. The purpose of this mass surveillance was for data collection of the transmission of the COVID-19. Though, many individuals around the world cited they felt this form of surveillance infringed on their privacy and basic human rights. Another concern regarding this level of surveillance was the lack of government or institutional policy documents regarding how to address the ethical challenges around mass surveillance to track a pandemic transmission rate. The use of this mass surveillance was used on a far larger scale compared to some of the other acts passed in recent years, as this had a more global focus due to the want to bring the transmission of COVID-19 to a halt. For example, on March 16, 2020, the Israeli government allowed emergency regulations regarding mass location tracking of citizens to slow the spread of the disease. Singapore and Taiwan also did something similar, yet their method of mass surveillance was allowing their law-enforcement agencies to monitor quarantine orders.
https://en.wikipedia.org/wiki?curid=699052
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"A. duodenale" is prevalent in Southern Europe, North Africa, India, China, Southeast Asia, small areas of United States, the Caribbean islands, and South America. This hookworm is well known in mines because of the consistency in temperature and humidity that provides an ideal habitat for egg and juvenile development. An estimated 1 billion people are infected with hookworms. Transmission of "A. duodenale" is by contact of skin with soil contaminated with larvae. The way it enters the human body was understood in the 1880s, after an epidemic of ancylostomiasis among miners working in the hot and humid Gotthard Tunnel (Switzerland).
https://en.wikipedia.org/wiki?curid=3444133
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The 1107 was the first 36-bit, word-oriented machine with an architecture close to that which came to be known as that of the "1100 Series." It ran the EXEC I or EXEC II operating system, batch-oriented second-generation operating systems, typical of the early to mid-1960s. The 1108 ran EXEC II or EXEC 8. EXEC 8 allowed simultaneous handling of real-time applications, time-sharing, and background batch work. Transaction Interface Package (TIP), a transaction-processing environment, allowed programs to be written in COBOL whereas similar programs on competing systems were written in assembly language. On later systems, EXEC 8 was renamed OS 1100 and OS 2200, with modern descendants maintaining backwards compatibility. Some more exotic operating systems ran on the 1108one of which was RTOS, a more bare-bones system designed to take better advantage of the hardware.
https://en.wikipedia.org/wiki?curid=144173
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The use of swarm intelligence in telecommunication networks has also been researched, in the form of ant-based routing. This was pioneered separately by Dorigo et al. and Hewlett Packard in the mid-1990s, with a number of variants existing. Basically, this uses a probabilistic routing table rewarding/reinforcing the route successfully traversed by each "ant" (a small control packet) which flood the network. Reinforcement of the route in the forwards, reverse direction and both simultaneously have been researched: backwards reinforcement requires a symmetric network and couples the two directions together; forwards reinforcement rewards a route before the outcome is known (but then one would pay for the cinema before one knows how good the film is). As the system behaves stochastically and is therefore lacking repeatability, there are large hurdles to commercial deployment. Mobile media and new technologies have the potential to change the threshold for collective action due to swarm intelligence (Rheingold: 2002, P175).
https://en.wikipedia.org/wiki?curid=762988
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Assortative mating based on socio-economic status is the broadest of these general categories. It includes the tendency of humans to prefer to mate within their socio-economic peers, that is, those with similar social standing, job prestige, educational attainment, or economic background as they themselves. This tendency has always been present in society: there was no historical area when most of the individuals preferred to sort, and had actually sorted, negatively into couples or matched randomly along these traits. Still, this tendency was weaker in some generations than in others. For instance, in the 20th century in the Western world, late Boomers had weaker aggregate preferences for educational homogamy than early Boomers had when being young adults; also, the members of the early Generation-X were typically much less "picky" about spousal education than the members of the late Generation-X were. This trend is evidenced by the search criteria of online dating site users.
https://en.wikipedia.org/wiki?curid=1112101
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Based on the assessment of Coupled Model Intercomparison Project 6 (CMIP6) models, AR6 concluded that it is very likely that, in the long term, global mean ocean precipitation will increase with increasing Global Surface Air Temperature. Annual mean and global mean precipitation will very likely increase by 1–3% per °C warming. Hereby, the precipitation patterns will also change and exhibit substantial regional and seasonal differences. Following the general trend ‘wet-gets-wetter-dry-gets-drier’, precipitation will very likely increase over high latitudes and the tropical ocean and likely increase in large parts of the monsoon regions, but likely decrease over the subtropics, including the Mediterranean, southern Africa and southwest Australia, in response to greenhouse-gas induced warming. Although these are the expected general trends there can be distinct deviations from those pattern changes on a local scale. One possible impact of the corresponding trend in ocean salinity is an altering of the Thermohaline Circulation, which is explained below.
https://en.wikipedia.org/wiki?curid=70383921
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During the ensuing Battle of Britain, the British fighter squadrons had to quickly relearn the old tactical lessons from the first war. Initially the RAF fighters flew in a tight three-fighter arrowhead formation, soon changing to the looser four-aircraft arrangement which the Germans called the "finger-four." They soon also relearned the value of climbing above your opponent before attacking. At the same time, the development of an early radar warning system by the British provided a new way to track German attack formations as they gathered over the European coast and flew across the English Channel. The radio communications, provided to every pilot, also required new protocols such as radio silence before engaging the enemy.
https://en.wikipedia.org/wiki?curid=33703683
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There are only 2 centres, right and left, numbered 3 and 4 respectively. They are usually positioned just inside the wingers and are typically the second-closest players to the touch-line on each side of the field. In attack their primary role is to provide an attacking threat out wide and as such they often need to be some of the fastest players on the pitch, often providing the pass for their winger to finish off a move. In defence, they are expected to mark their opposite centre. Centres that feature in their countries' halls of fame are France's Max Rousié, England's Eric Ashton, Harold Wagstaff and Neil Fox, Wales' Gus Risman and Australia's Reg Gasnier, H "Dally" Messenger, Dave Brown, Jim Craig, Bob Fulton and Mal Meninga.
https://en.wikipedia.org/wiki?curid=1195281
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In 2011, a military-configured variant, the AW139M, was revealed by AgustaWestland. It was promoted at the US market, including for the U.S. Air Force's Common Vertical Lift Support Program. The AW139M is equipped with a high definition forward-looking infrared (FLIR), self-protection system, heavy-duty landing gear, and has low thermal and acoustic signatures; a significant proportion of the equipment is sourced from American manufacturers. Options offered include an external stores system including various armaments, armoured seats, self-sealing fuel tanks, and a full ice protection system for all-weather operations.
https://en.wikipedia.org/wiki?curid=6378164
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Each scale is specific to the individual, and the defined points are indirectly related to mental health goals. GAS can therefore be individualized, yet universal in its meaningfulness. Communication is enabled through specificity and the well-defined nature of the measure. As an evaluation method, GAS has many uses. GAS can be used to compare treatments or to simply evaluate treatment effectiveness with one client. GAS is used to scale treatment goals, and then their level of attainment are measured. It is a valid individualized treatment outcome and program evaluation measure. Further, GAS is an easy, low cost, evaluation technique. As many treatments will incorporate several goals, GAS can be used to track multiple goals. The goals can be prioritized and differentially weighted to reflect treatment objectives. This goal-oriented measurement tool creates specific operational indicators of progress and can focus case planning and treatment. This often results in better outcomes. GAS results in specific goal attainment indicators, making effectiveness readily apparent. It also promotes positive perceptions of progress towards a goal, which further aids in goal attainment. GAS combines behavioral definitions, mutually defining goals, clear expectations, and continuous evaluation to improve client outcomes and effectively measure change.
https://en.wikipedia.org/wiki?curid=41397509
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In this formalism, a liquid crystal material is treated as a continuum; molecular details are entirely ignored. Rather, this theory considers perturbations to a presumed oriented sample. The distortions of the liquid crystal are commonly described by the Frank free energy density. One can identify three types of distortions that could occur in an oriented sample: (1) twists of the material, where neighboring molecules are forced to be angled with respect to one another, rather than aligned; (2) splay of the material, where bending occurs perpendicular to the director; and (3) bend of the material, where the distortion is parallel to the director and molecular axis. All three of these types of distortions incur an energy penalty. They are distortions that are induced by the boundary conditions at domain walls or the enclosing container. The response of the material can then be decomposed into terms based on the elastic constants corresponding to the three types of distortions. Elastic continuum theory is an effective tool for modeling liquid crystal devices and lipid bilayers.
https://en.wikipedia.org/wiki?curid=17973
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In the United States Navy, captain was the highest rank from 1775 until 1857, when the United States Congress created the rank of flag officer. The modern rank of captain (abbreviated CAPT) is a senior officer rank, with the pay grade of O-6. It ranks above commander and below rear admiral (lower half). It is equivalent to the rank of colonel in the other uniformed services. Promotion to captain is governed by Department of Defense policies derived from the Defense Officer Personnel Management Act (DOPMA) of 1980 or its companion Reserve Officer Personnel Management Act (ROPMA). DOPMA/ROPMA guidelines suggest that no more than 50% of eligible commanders should be promoted to captain after serving a minimum of three years at their present rank and after attaining 21–23 years of cumulative commissioned service, although this percentage may be appreciably less, contingent on force structure and the needs of the service. With very few exceptions, such as Naval Aviator Astronaut and Naval Flight Officer Astronaut, unrestricted line officer captains in the Navy will have successfully completed at least one commanding officer assignment at the commander (O-5) level, typically a destroyer or frigate for surface warfare officers, a nuclear-powered attack submarine or ballistic missile submarine for submarine warfare officers, a SEAL team for special warfare officers, or an aviation squadron for Naval Aviators and Naval Flight Officers, before being selected for promotion to captain. All those selected to the rank of captain by the U.S. Navy are confirmed by the United States Senate.
https://en.wikipedia.org/wiki?curid=38410533
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Kansas State University Salina Aerospace and Technology Campus and the College of Technology and Aviation were established in 1991 as a result of the merger of the Kansas Technical Institute with Kansas State University. It offers degree programs in the fields of engineering technology and aviation, consisting of associate and bachelor's degrees as well as a Professional Master of Technology program. Approximately 1,000 students are enrolled at the Salina campus. About 85 percent of the student body comes from Kansas and 80 percent attends on a full-time basis. Students are not required to live on campus but do have the option of living in one of two suite-style residence halls. Classes are small; first-year English and speech courses are limited to 25 students. Engineering technology and aviation maintenance students begin hands-on classes their first semester and pilot students begin flying as early as the first week of school. Campus facilities include laboratories for student projects and three runways adjacent to campus.
https://en.wikipedia.org/wiki?curid=8167095
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Antenna-related research programs characterize antenna gain characteristics, develop phased array antenna concepts, and develop various kinds of reflector-type and lens antennas. In the field of electromagnetic environmental effects, SEAL researchers analyze, measure, and control the electromagnetic interactions among elements of an electronic system and between the system and its environment. Additional research areas include sensor development for ballistic missile defense, physical security, meteorology, space-based surveillance and detection, transportation applications, engineering data analysis and modeling for sustainment of complex electronic systems, and customer-tailored short courses in electronic defense.
https://en.wikipedia.org/wiki?curid=4787085
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The Japanese held strong defensive fortifications on Mount Austen as well as on two nearby ridges: Seahorse and Galloping Horse. Offensive operations to capture the three locations began on 7 January 1943. Despite the fact that the 65th Engineer Battalion was poorly equipped, they aided in the seizure of the key terrain by opening roads and maintaining lines of communication. They also opened up supply routes to the interior by dredging the Matanikau River allowing free movement for boats. In January 1943 XIV Corps went on the offensive. As XIV Corps moved into the Northern Solomons, New Georgia, Vella LaVella, Sasavele, and Kolombangara, the 65th Engineer Battalion continued to support freedom of maneuver and facilitate resupply routes by improving roads and trails and building bridges and fording sites.
https://en.wikipedia.org/wiki?curid=53448185
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Bates is noted as one of the Little Ivies, along with universities such as Tufts, Bowdoin, Colby, Amherst, Middlebury, Connecticut College, Hamilton, Trinity, Wesleyan, and Williams. The college is also known as one of the Hidden Ivies, which includes much larger research universities such as Johns Hopkins and Stanford University. The 2020 annual ranking by "U.S. News & World Report" ranked Bates tied for 21st overall best liberal arts college in the nation. "Forbes" ranked Bates 39th in its 2019 national rankings of 650 U.S. colleges, universities and service academies, and 11th among liberal arts colleges. The college's highest ranking on the "Forbes" tables was 8th in the U.S. during its 2018 listing. "Washington Monthly" ranked Bates 17th in 2019 among 214 liberal arts colleges in the U.S. based on its contribution to the public good, as measured by social mobility, research, and promoting public service. The peak position Bates has held on the "Washington Monthly" ranking was 6th in 2013.
https://en.wikipedia.org/wiki?curid=319763
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From his brain-storming about transmutation towards the end of 1838, Darwin conceived of his theory of natural selection "by which to work", as his "prime hobby". His main work on the "Beagle" collections continued, and in 1842 he published the first of three volumes on geology, "The Structure and Distribution of Coral Reefs". He then allowed himself to write out the first "pencil sketch" of his theory. Subsequently, in September 1842, the family moved to rural Down House where he had space for experimental plant and animal breeding, and surroundings to observe nature. In December of that year he had a quantity of broken chalk spread over a part of a long established pasture field near the house, "for the sake of observing at some future period to what depth it would become buried."
https://en.wikipedia.org/wiki?curid=21460789
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On 19 August, the units of VIII. Fliegerkorps moved up from their bases around Cherbourg-Octeville and concentrated in the Pas de Calais under Luftflotte 2, closer to the area of the proposed invasion of Britain. On 13 September, the Luftwaffe targeted airfields again, with a small number of Ju 87s crossing the coast at Selsey and heading for Tangmere. After a lull, anti-shipping operations attacks were resumed by some Ju 87 units from 1 November 1940, as part of the new winter tactic of enforcing a blockade. Over the next 10 days, seven merchant ships were sunk or damaged, mainly in the Thames Estuary, for the loss of four Ju 87s. On 14 November 19 Stukas from III./St.G 1 with escort drawn from JG 26 and JG 51 went out against another convoy; as no targets were found over the estuary, the Stukas attacked Dover, their alternative target.
https://en.wikipedia.org/wiki?curid=16590
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The maximum length of the mouse catshark has been variously reported as and . The larger figure comes from Iceland and is reflective of the aforementioned taxonomic confusion, as the specimen of "P. jensenii" described by Bjarni Sæmundsson was long. This species has a firm body with a rather long, blunt snout. The nostrils are divided by triangular flaps of skin in front. The eyes are horizontally oval and equipped with rudimentary nictitating membranes (protective third eyelids). A thin ridge is present beneath each eye, and a tiny spiracle behind. The large mouth forms a wide arch, and bears well-developed furrows at the corners. The teeth have a narrow central cusp and multiple lateral cusplets on either side. There are five pairs of gill slits.
https://en.wikipedia.org/wiki?curid=7299965
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The knowledge of the geology of the Surinamese coastal plain has increased in the 20th century. In 1931 IJzerman gave a general description of the sediments that occur in the foreland. He distinguished two layers of groups: the fluvio-marine deposits, in which clays and sands occur and the older continental alluvium, for a large part consisting of coarse white, sometimes humus-bearing sands. The fluvio-marine deposits lie in a belt immediately along the coast and the continental alluvium comes to the surface in a belt behind it, wedging against the rocks of the Guiana Shield. The geologist Jan Zonneveld, who worked at the Centraal Bureau Luchtkartering in Paramaribo, around 1950, after studying the use of water level profiles, field research and the interpretation of aerial photographs, was of the opinion that on the surface not two, but three elements should be distinguished, namely from north to south:
https://en.wikipedia.org/wiki?curid=58206850
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In December 2010, the U.S. Food and Drug Administration (FDA) notified its intention to remove the breast cancer indication from bevacizumab, saying that it had not been shown to be safe and effective in breast cancer patients. The combined data from four different clinical trials showed that bevacizumab neither prolonged overall survival nor slowed disease progression sufficiently to outweigh the risk it presents to patients. This only prevented Genentech from marketing bevacizumab for breast cancer. Doctors are free to prescribe bevacizumab off label, although insurance companies are less likely to approve off-label treatments. In June 2011, an FDA panel unanimously rejected an appeal by Roche. A panel of cancer experts ruled for a second time that Avastin should no longer be used in breast cancer patients, clearing the way for the U.S. government to remove its endorsement from the drug. The June 2011 meeting of the FDA's oncologic drug advisory committee was the last step in an appeal by the drug's maker. The committee concluded that breast cancer clinical studies of patients taking Avastin have shown no advantage in survival rates, no improvement in quality of life, and significant side effects.
https://en.wikipedia.org/wiki?curid=1527537
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About a year before closing, in February 1996, RSG announced a partnership with CyberCash, Inc. to launch a virtual arcade service based on micropayments. CyberCash, a virtual currency company, would provide the financial infrastructure for the arcade and use it to jump-start their micropayment "electronic coin service". This announcement was heavily circulated by the media and, along with several other micropayment based services, was heralded as the next big thing in Internet commerce. The arcade was to be based on RSG "V3 Internet game engine" and feature at least 20 classic arcade games with a launch as early as the second half of 1996. The unnamed service was never given a firm launch date nor were any specific titles mentioned. After the initial flurry of excitement the partnership failed to produce any further announcements and the service was never heard from again. It may have been a casualty of the cuts SegaSoft made later that same year when they acquired RSG. Later SegaSoft partnered with CyberCash and used their micropayment system, now named the CyberCoin service, for their Heat.net online gaming service. Heat.net was shut down in 2000 when SegaSoft was restructured into Sega.com and CyberCash filed for bankruptcy a year later.
https://en.wikipedia.org/wiki?curid=5228695
1,081,693
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In 2006 Fei-Fei Li, the co-director of the Stanford Human-Centered AI Institute, set out to improve the artificial intelligence models and algorithms for image recognition by significantly enlarging the training data. The researchers downloaded millions of images from the World Wide Web and a team of undergraduates started to apply labels for objects to each image. In 2007 Li outsourced the data labelling work on Amazon Mechanical Turk, an online marketplace for digital piece work. The 3.2 million images that were labelled by more than 49,000 workers formed the basis for ImageNet, one of the largest hand-labeled database for outline of object recognition.
https://en.wikipedia.org/wiki?curid=54033657
1,203,157
10,702
By late 2002, 89% of U.S. troops reported they were confident with the M4, but they had a range of problems. 34% of users said the handguards rattled and became excessively hot when firing, and 15% had trouble zeroing the M68 Close Combat Optic. 35% added barber brushes and 24% added dental picks to their cleaning kits. There were many malfunctions, including 20% of users experiencing a double feed, 15% experiencing feeding jams, and 13% saying that feeding problems were caused by magazines. 20% of users were dissatisfied with weapon maintenance. Some had trouble locking the magazine into the weapon and having to chamber a round in order to lock the magazine. Soldiers also asked for a larger round to be able to kill targets with one shot. New optics and handguards made usage of the M4 easier, and good weapon maintenance reduced the number of misfeeds.
https://en.wikipedia.org/wiki?curid=321957
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It is also convenient to fix a notation for the coefficients of the initial Lanczos vector formula_39 with respect to this eigenbasis; let formula_251 for all formula_249, so that formula_253. A starting vector formula_39 depleted of some eigencomponent will delay convergence to the corresponding eigenvalue, and even though this just comes out as a constant factor in the error bounds, depletion remains undesirable. One common technique for avoiding being consistently hit by it is to pick formula_39 by first drawing the elements randomly according to the same normal distribution with mean formula_256 and then rescale the vector to norm formula_20. Prior to the rescaling, this causes the coefficients formula_258 to also be independent normally distributed stochastic variables from the same normal distribution (since the change of coordinates is unitary), and after rescaling the vector formula_259 will have a uniform distribution on the unit sphere in formula_260. This makes it possible to bound the probability that for example formula_261.
https://en.wikipedia.org/wiki?curid=2593852
707,267
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Main oxidative degradation products of MDEA include monoethanol amine (MEA), methyl-aminoethanol (MAE), diethanolamine (DEA), amino acids bicine, glycine and hydroxyethyl sarcosine (HES), formyl amides of MAE and DEA, ammonia, and stable salts formate, glycolate, acetate, and oxalate. In an industrial plan that utilizes MDEA, oxidative degradation is most likely to shift to the cross exchanger where temperatures are greater than 70 °C. Higher temperatures and higher CO loading accelerate the rate of degradation, resulting in an increase of alkalinity loss as well as total formate production. While MDEA is more resistant to degradation as a standalone compared to MEA, MDEA is preferentially degraded when in an MDEA/MEA blend. Because of the formation of DEA and MAE, which could form nitroso-compounds or diethylnitrosamine and diethylnitraine, the blend could potentially have an adverse impact in terms of atmospheric admissions. In the Boundary Dam plant, emissions increased when CO loading of lean amine increased for the blend and MEA. However, decreasing the lean loading increases the reboiler heat duty, which results in an obvious tradeoff between emissions and heat duty or energy costs.
https://en.wikipedia.org/wiki?curid=17403365
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More recent ice core samples of today's glacial ice substantiated the cycles through studies of ancient pollen deposition. Currently a number of methods are making additional detail possible. Matching the stages to named periods proceeds as new dates are discovered and new regions are explored geologically. The marine isotopic records appear more complete and detailed than any terrestrial equivalents, and have enabled a timeline of glaciation for the Plio-Pleistocene to be identified. It is now believed that changes in the size of the major ice sheets such as the historical Laurentide Ice Sheet of North America are the main factor governing variations in the oxygen isotope ratios.
https://en.wikipedia.org/wiki?curid=2289787
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The "Journal of Women's Health" surveyed physician mothers and their physician daughters in order to analyze the effect that discrimination and harassment have on the individual and their career. This study included 84% of physician mothers that graduated medical school prior to 1970, with the majority of these physicians graduating in the 1950s and 1960s. The authors of this study stated that discrimination in the medical field persisted after the title VII discrimination legislation was passed in 1965.<ref name="10.1089/jwh.2006.0127"></ref> This was the case until 1970, when the National Organization for Women (NOW) filed a class action lawsuit against all medical schools in the United States. By 1975, the number of women in medicine had nearly tripled, and has continued to grow. By 2005, more than 25% of physicians and around 50% of medical school students were women. The increase of women in medicine also came with an increase of women identifying as a racial/ethnic minority, yet this population is still largely underrepresented in comparison to the general population of the medical field.
https://en.wikipedia.org/wiki?curid=14457458
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A small spontaneous pneumothorax will typically resolve without treatment and requires only monitoring. This approach may be most appropriate in people who have no underlying lung disease. In a larger pneumothorax, or if there is shortness of breath, the air may be removed with a syringe or a chest tube connected to a one-way valve system. Occasionally, surgery may be required if tube drainage is unsuccessful, or as a preventive measure, if there have been repeated episodes. The surgical treatments usually involve pleurodesis (in which the layers of pleura are induced to stick together) or pleurectomy (the surgical removal of pleural membranes). About 17–23 cases of pneumothorax occur per 100,000 people per year. They are more common in men than women.
https://en.wikipedia.org/wiki?curid=286359
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Copland never enrolled as a member of any political party. Nevertheless, he inherited a considerable interest in civic and world events from his father. His views were generally progressive and he had strong ties with numerous colleagues and friends in the Popular Front, including Odets. Early in his life, Copland developed, in Pollack's words, "a deep admiration for the works of Frank Norris, Theodore Dreiser and Upton Sinclair, all socialists whose novels passionately excoriated capitalism's physical and emotional toll on the average man." Even after the McCarthy hearings, he remained a committed opponent of militarism and the Cold War, which he regarded as having been instigated by the United States. He condemned it as "almost worse for art than the real thing." Throw the artist "into a mood of suspicion, ill-will, and dread that typifies the cold war attitude and he'll create nothing".
https://en.wikipedia.org/wiki?curid=51298
382,438
1,640,673
Residuum and their associated residual soils are a produced primarily through chemical weathering of their bedrock. Residuum occurs in all temperature regimes and locations. Their thickness varies with climates. In temperate climate its presence is in relatively lower amounts occurring as a “thin blanket of loose material above the bedrock. In tropical climates it can be much thicker”. A certain degree of landscape stability is inferred for residual soils. Identification and survey of these soils are most conclusive "where fresh outcrops are rare and all surface materials look alike". In contrast, "a decrease in the amount of rock fragments as depth increases, especially over saprolite, indicates that the soil materials probably has been transported down slope". Identification of residuum is relevant in soil science and geology because accurate identification conveys direct and implicit info about soil itself, the environment in which it formed, and its current environment. Soils provide a records of prevailing and past environments climates and human activities and much more.
https://en.wikipedia.org/wiki?curid=45020815
1,639,746
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Enormous quantities of stone were needed for these structures and the remains of the numerous quarries used can still be found, especially in the vicinity of Jerusalem's Old City, notably those to the north known as Solomon's Quarries. Freeing the stones from the bedrock was an elaborate process: Wide grooves were chiseled with metal tools around the intended stone block. The block was then freed up by driving metal wedges into the grooves. The initial dressing of the stone was probably accomplished on site before transport. Many of these stones were very large, weighing between two and five tons. (The largest found, in the Western Wall Tunnel, measures some 12.8 meters in length, 3.4 meters high and 4.3 meters deep; it weighs about 660 tons.) Once moved to the building site, further fine chiseling was done and the blocks were hauled into place using ramps, cranes and crow bars. The stones were laid in dry courses, typically about 1 meter high without the use of any mortar. Each course was set 3 to 5 cm back from the course underneath it. Final dressing and refinements were carried out once the stones had been set in place.
https://en.wikipedia.org/wiki?curid=19344555
1,298,091
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A small terracotta sculpture of a head, with a beard and European-like features, was found in 1933 in the Toluca Valley, southwest of Mexico City, in a burial offering under three intact floors of a pre-colonial building dated to between 1476 and 1510. The artifact has been studied by Roman art authority Bernard Andreae, director emeritus of the German Institute of Archaeology in Rome, Italy, and Austrian anthropologist Robert von Heine-Geldern, both of whom stated that the style of the artifact was compatible with small Roman sculptures of the 2nd century. If genuine and if not placed there after 1492 (the pottery found with it dates to between 1476 and 1510), the find provides evidence for at least a one-time contact between the Old and New Worlds.
https://en.wikipedia.org/wiki?curid=158687
180,681
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The foraminifera "Spiculosiphon" preferentially agglutinates silica sponge spicules using an organic cement; it shows strong selectivity also towards shape, utilising elongated spicules on its "stalk" and shortened ones on its "bulb". It is thought to use the spicules as both a means of elevating itself off the seabed as well as to lengthen the reach of its pseudopodia to capture prey.The agglutinated tests of xenophyophores are the largest of any foraminifera, reaching up to 20 cm in diameter. The name "xenophyophore", meaning "bearer of foreign bodies", refers to this agglutinating habit. Xenophyophores selectively uptake sediment grains between 63 and 500 µm, avoiding larger pebbles and finer silts; type of sediment seems to be a strong factor in which particles are agglutinated, as particle type preferentially includes sulfides, oxides, volcanic glass, and especially tests of smaller foraminifera. Xenophyophores 1.5 cm in diameter have been recorded completely naked, with no test whatsoever.
https://en.wikipedia.org/wiki?curid=68683770
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The Jewish community of the island of Djerba in Tunisia is of special interest, Tradition traces this community's origins back to the time of the destruction of Solomon's Temple. Two studies have attempted to test this hypothesis first by G. Lucotte et al. from 1993, the second of F. Manni et al. of 2005. They also conclude that the Jews of Djerba's paternal gene pool is different from the Arabs and Berbers of the island. For the first 77.5% of samples tested are of haplotype VIII (probably similar to the J haplogroup according Lucotte), the second shows that 100% of the samples are of Haplogroup J *. The second suggests that it is unlikely that the majority of this community comes from an ancient colonization of the island while for Lucotte it is unclear whether this high frequency is really an ancient relationship. These studies therefore suggest that the paternal lineage of North African Jews comes predominantly from the Middle East with a minority contribution of African lineages, probably Berbers.
https://en.wikipedia.org/wiki?curid=26118437
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While this process does manage to fix a large amount of carbon, two units of alkalinity are sequestered for every unit of sequestered carbon. The formation and sinking of CaCO therefore drives a surface to deep alkalinity gradient which serves to raise the pH of surface waters, shifting the speciation of dissolved carbon to raise the partial pressure of dissolved CO in surface waters, which actually raises atmospheric levels. In addition, the burial of CaCO in sediments serves to lower overall oceanic alkalinity, tending to raise pH and thereby atmospheric CO levels if not counterbalanced by the new input of alkalinity from weathering. The portion of carbon that is permanently buried at the sea floor becomes part of the geologic record. Calcium carbonate often forms remarkable deposits that can then be raised onto land through tectonic motion as in the case with the White Cliffs of Dover in Southern England. These cliffs are made almost entirely of the plates of buried coccolithophores.
https://en.wikipedia.org/wiki?curid=67766374
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While this process does manage to fix a large amount of carbon, two units of alkalinity are sequestered for every unit of sequestered carbon. The formation and sinking of CaCO therefore drives a surface to deep alkalinity gradient which serves to raise the pH of surface waters, shifting the speciation of dissolved carbon to raise the partial pressure of dissolved CO in surface waters, which actually raises atmospheric levels. In addition, the burial of CaCO in sediments serves to lower overall oceanic alkalinity, tending to raise pH and thereby atmospheric CO levels if not counterbalanced by the new input of alkalinity from weathering. The portion of carbon that is permanently buried at the sea floor becomes part of the geologic record. Calcium carbonate often forms remarkable deposits that can then be raised onto land through tectonic motion as in the case with the White Cliffs of Dover in Southern England. These cliffs are made almost entirely of the plates of buried coccolithophores.
https://en.wikipedia.org/wiki?curid=240228
582,266
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In 1999, Cavazzoni et al. predicted that such a state would exist for ammonia and water in conditions such as those existing on Uranus and Neptune. In 2005 Laurence Fried led a team at Lawrence Livermore National Laboratory to recreate the formative conditions of superionic water. Using a technique involving smashing water molecules between diamonds and super heating it with lasers they observed frequency shifts which indicated that a phase transition had taken place. The team also created computer models which indicated that they had indeed created superionic water. In 2013 Hugh F. Wilson, Michael L. Wong, and Burkhard Militzer at the University of California, Berkeley published a paper predicting the face-centered cubic lattice structure that would emerge at higher pressures.
https://en.wikipedia.org/wiki?curid=30078913
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Construction of SIMUL8 models is usually not based on programming or statistical data, but rather on drawing organization schemes on the screen. However, SIMUL8 implements a two-way interface with Visual Basic, which leaves space for creation of advanced model features, which cannot be modeled using only the graphical interface. SIMUL8 also provides its own simulation language optimized for simulation processing, called Visual Logic, which allows the user to implement detailed logic of the simulation. The design of SIMUL8 also facilitates communication with other software packages such as Microsoft Access, Excel and Visio. The support of XML and OLE automation allows working with external sources of data and exporting internal data to other systems. SIMUL8 also supports communication with databases using SQL.
https://en.wikipedia.org/wiki?curid=21225939
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Cosmic rays have sufficient energy to alter the states of circuit components in electronic integrated circuits, causing transient errors to occur (such as corrupted data in electronic memory devices or incorrect performance of CPUs) often referred to as "soft errors". This has been a problem in electronics at extremely high-altitude, such as in satellites, but with transistors becoming smaller and smaller, this is becoming an increasing concern in ground-level electronics as well. Studies by IBM in the 1990s suggest that computers typically experience about one cosmic-ray-induced error per 256 megabytes of RAM per month. To alleviate this problem, the Intel Corporation has proposed a cosmic ray detector that could be integrated into future high-density microprocessors, allowing the processor to repeat the last command following a cosmic-ray event. ECC memory is used to protect data against data corruption caused by cosmic rays.
https://en.wikipedia.org/wiki?curid=47687
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Starting hematologists (in the US) complete a four-year medical degree followed by three or four more years in residency or internship programs. After completion, they further expand their knowledge by spending two or three more years learning how to experiment, diagnose, and treat blood disorders. When applying for this career, most job openings look for first-hand practical experience in a recognized training program that provides practice in the following: Cause of abnormalities in formation of blood and other disorders, diagnosis of numerous blood related conditions or cancers using experimentation, and the proper care and treatment of patients in the best manner. There are two parts in training of hematology; one is clinical hematology and another is hematopathology.
https://en.wikipedia.org/wiki?curid=63564
407,357
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The most frequently used methods to map and measure snow extent, snow depth and snow water equivalent employ multiple inputs on the visible–infrared spectrum to deduce the presence and properties of snow. The National Snow and Ice Data Center (NSIDC) uses the reflectance of visible and infrared radiation to calculate a normalized difference snow index, which is a ratio of radiation parameters that can distinguish between clouds and snow. Other researchers have developed decision trees, employing the available data to make more accurate assessments. One challenge to this assessment is where snow cover is patchy, for example during periods of accumulation or ablation and also in forested areas. Cloud cover inhibits optical sensing of surface reflectance, which has led to other methods for estimating ground conditions underneath clouds. For hydrological models, it is important to have continuous information about the snow cover. Applicable techniques involve interpolation, using the known to infer the unknown. Passive microwaves sensors are especially valuable for temporal and spatial continuity because they can map the surface beneath clouds and in darkness. When combined with reflective measurements, passive microwave sensing greatly extends the inferences possible about the snowpack.
https://en.wikipedia.org/wiki?curid=52434656
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As the cognitive ability and intelligence in non-human animals cannot be measured with verbal scales, it has been measured using a variety of methods that involve such things as habit reversal, social learning, and responses to novelty. Principal component analysis and factor analytic studies have shown that a single factor of intelligence is responsible for 47% of the individual variance in cognitive ability measures in primates and between 55% and 60% of the variance in mice. These values are similar to the accepted variance in IQ explained by a similar single factor known as the general factor of intelligence in humans (40-50%). However, results from a recent meta-analysis suggest that the average correlation between performance scores on various cognitive tasks is only 0.18. Results from this study suggest that current evidence for general intelligence is weak in non-human animals.
https://en.wikipedia.org/wiki?curid=425938
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Each year of the 1990s saw an increase in the SAT scores of undergraduate applicants, the university gained campus chapters of Alpha Lambda Delta and the Golden Key International Honour Society, the undergraduate Honors Program expanded from 65 students into the Honors College with 400 students in 2013, and the university also had enrolled its first Fulbright scholars. Between 1996 and 2000, the number of undergraduate STEM majors at the school increased by 20 percent, and in computer science alone enrollment increased by two-thirds, and biochemistry, earth and geographic sciences all by one-third. Enrollment steadily increased during Chancellor Penney's tenure to 12,482 total students and 2,866 graduate students by 2000, and the university went from one in twelve students who were minority or female in 1988 to one in three by 2000. The percentage of faculty that was black rose from 13 percent in 1988 to 20 percent in 2000, and the percentage of faculty that was female rose from less than one-third in 1988 to 41 percent in 2000.
https://en.wikipedia.org/wiki?curid=99867
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The works started on 1502 and took 15 years to be completed. At great personal expense, Cardinal Cisneros acquired many manuscripts and invited the top religious scholars of the day, to work on the ambitious task of compiling a massive and complete polyglot "to revive the languishing study of the Sacred Scriptures". Diego López de Zúñiga, was the chief editor and fluent in Latin as well as both Aramaic and Arabic. He was given a team of various translators. Converted translators and academics were favoured and specifically sought since they were fluent in the source languages and the cultures of the texts. Second in command, Alfonso de Zamora (14761544) was a converted Jewish scholar, an expert in Talmudic studies, and spoke Hebrew as his first language. Other "conversos" working on the project were Alfonso de Alcalá, Pablo de Coronel. Demetrius Ducas a scholar from Crete, Hernán Núñez de Toledo ("The Pincian") and Juan de Vergara were in charge of the translation from Greek manuscripts. Antonio de Nebrija was specifically called for the translation of the Vulgate. Hernán Núñez de Toledo was also the chief Latinist.
https://en.wikipedia.org/wiki?curid=1278428
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Antiphase domains carry with them a surface energy penalty when compared to the perfect lattice due to their chemical disorder, and the presence of these boundaries impedes dislocation motion throughout the crystal, leading to increased strength under shear stress. Figure 3 below shows the process of an edge dislocation propagating through an ordered particle. As the dislocation moves throughout the particle, lattice planes are displaced from their equilibrium configuration, and A-A bonds and B-B bonds are formed throughout the slip plane. This forms a higher energy state than when compared to the equilibrium A-B bonding configuration, and the change in energy is called the anti-phase boundary energy (APBE). This can increase the degree of strengthening created from precipitation hardening, making it more difficult for cutting to occur, and instead increasing the likelihood of Orowan bowing around the precipitate.
https://en.wikipedia.org/wiki?curid=26381831
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Other Patriot women concealed army dispatches and letters containing sensitive military information underneath their petticoats as they rode through enemy territory to deliver it. Deborah Sampson, Harriet Prudence Patterson Hall, and Lydia Darragh all managed to sneak important information past the British to their American compatriot. On the night of April 26, 1777, sixteen-year-old Sybil Ludington is said to have ridden 40 miles through the villages of Putnam County, New York, knocking on farmhouse doors to warn militiamen that British troops were on their way to Danbury, Connecticut. She has received widespread recognition as the female Paul Revere; a report in "The New England Quarterly" says there is little evidence backing the story, and whether the ride occurred is questioned.
https://en.wikipedia.org/wiki?curid=11003821
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Within the SML, viruses interacting with the bacterioneuston will probably induce the viral shunt, a phenomenon that is well known for marine pelagic systems. The term viral shunt describes the release of organic carbon and other nutritious compounds from the virus-mediated lysis of host cells, and its addition to the local dissolved organic matter (DOM) pool. The enriched and densely packed bacterioneuston forms an excellent target for viruses compared to the bacterioplankton populating the subsurface. This is because high host-cell numbers will increase the probability of host–virus encounters. The viral shunt might effectively contribute to the SML's already high DOM content enhancing bacterial production as previously suggested for pelagic ecosystems and in turn replenishing host cells for viral infections. By affecting the DOM pool, viruses in the SML might directly interfere with the microbial loop being initiated when DOM is microbially recycled, converted into biomass, and passed along the food web. In addition, the release of DOM from lysed host cells by viruses contributes to organic particle generation. However, the role of the virioneuston for the microbial loop has never been investigated.
https://en.wikipedia.org/wiki?curid=12264442
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One study found that the in vitro concentration (titer) of neutralizing antibodies elicited by a COVID-19 vaccine is a strong correlate of immune protection. The relationship between protection and neutralizing activity is nonlinear. A neutralization as low as of the level of convalescence results in 50% efficacy against severe disease, with resulting in 50% efficacy against detectable infection. Protection against infection quickly decays, leaving individuals susceptible to mild infections, while protection against severe disease is largely retained and much more durable. The observed half-life of neutralizing titers was 65 days for mRNA vaccines (Pfizer–BioNTech, Moderna) during the first 4 months, increasing to 108 days over 8 months. Greater initial efficacy against infection likely results in a higher level of protection against serious disease in the long term (beyond 10 years, as seen in other vaccines such as smallpox, measles, mumps, and rubella), although the authors acknowledge that their simulations consider only protection from neutralizing antibodies and ignore other immune protection mechanisms, such as cell-mediated immunity, which may be more durable. This observation also applies to efficacy against variants and is particularly significant for vaccines with a lower initial efficacy; for example, a 5-fold reduction in neutralization would indicate a reduction in initial efficacy from 95% to 77% against a specific variant, and from a lower efficacy of 70% to 32% against that variant. For the Oxford–AstraZeneca vaccine, the observed efficacy is below the predicted 95% confidence interval. It is higher for Sputnik V and the convalescent response, and is within the predicted interval for the other vaccines evaluated (Pfizer–BioNTech, Moderna, Janssen, CoronaVac, Covaxin, Novavax).
https://en.wikipedia.org/wiki?curid=68597435
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Such a consensus would necessarily exclude some doctrines, namely, those that are "unreasonable", and so one may wonder what Rawls has to say about such doctrines. An unreasonable comprehensive doctrine is unreasonable in the sense that it is incompatible with the duty of civility. This is simply another way of saying that an unreasonable doctrine is incompatible with the fundamental political values a liberal theory of justice is designed to safeguard—freedom, equality and fairness. So one answer to the question of what Rawls has to say about such doctrines is—nothing. For one thing, the liberal state cannot justify itself to individuals (such as religious fundamentalists) who hold to such doctrines, because any such justification would—as has been noted—proceed in terms of controversial moral or religious commitments that are excluded from the public political forum. But, more importantly, the goal of the Rawlsian project is primarily to determine whether or not the liberal conception of political legitimacy is internally coherent, and this project is carried out by the specification of what sorts of reasons persons committed to liberal values are permitted to use in their dialogue, deliberations and arguments with one another about political matters. The Rawlsian project has this goal to the exclusion of concern with justifying liberal values to those not already committed—or at least open—to them. Rawls's concern is with whether or not the idea of political legitimacy fleshed out in terms of the duty of civility and mutual justification can serve as a viable form of public discourse in the face of the religious and moral pluralism of modern democratic society, not with justifying this conception of political legitimacy in the first place.
https://en.wikipedia.org/wiki?curid=123612
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is to obtain a clear understanding of the individual, of their social circumstances and of their environment in order to develop a treatment plan that will improve their quality of life. Individuals with DMD often experience difficulties in areas of self-care, productivity and leisure. This is related to the effects of the disorder, such as decreased mobility; decreased strength and postural stability; progressive deterioration of upper-limb function; and contractures. Occupational and physical therapists address an individual's limitations using meaningful occupations and by grading the activity, by using different assessments and resources such as splinting, bracing, manual muscle testing (MMT), ROM, postural intervention and equipment prescription.
https://en.wikipedia.org/wiki?curid=47148883
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Ultrasound guidance is used continuously throughout the course of the procedure so that the needle is always visualized. A sterile 20–22 gauge spinal needle is firmly inserted perpendicular to the maternal abdomen. After puncturing the maternal abdomen, the operator punctures the uterus, gains access into amniotic cavity by puncturing the amniotic membrane while taking care not to cause membrane tenting, and proceeds to advance the needle into the amniotic cavity. The needle should be guided into the region of the maximum vertical pocket, where the single largest area of amniotic fluid devoid of fetal parts, umbilical cord, and placenta is available for sampling. Amniotic fluid is composed of fetal cells, urine, and lung secretions. 18-20 mL of amniotic fluid is slowly aspirated, with the first 1-2 mL typically discarded due to higher risk of maternal cell contamination. The remaining sample is submitted for laboratory testing. Fetal viability after the procedure should be confirmed by observing adequate fetal cardiac activity. The number of needle puncture attempts should be documented.
https://en.wikipedia.org/wiki?curid=187698
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In pre-modern times, environmental issues were not widely discussed, though Ashoka banned the burning of forests and promoted the planting of trees in his edicts. Bhikkhu Bodhi, an American Theravada monk, has been outspoken about the issue of environmental crisis. Bodhi holds that the root of the current ecological crisis is the belief that increased production and consumption to satisfy our material and sensual desires leads to well-being. The subjugation of nature is directly opposed to the Buddhist view of non-harming and dwelling in nature. Buddhist activists such as Ajahn Pongsak in Thailand and the Sarvodaya Shramadana Movement have worked for reforestation and environmental protection. The Dalai Lama also professes the close relationship of human beings and nature, saying that since humans come from nature, there is no point in going against it. He advocates that a clean environment should be considered a basic human right and that it is our responsibility as humans to ensure that we do all we can to pass on a healthy world to those who come after us.
https://en.wikipedia.org/wiki?curid=4746907
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