doc_id
int32
18
2.25M
text
stringlengths
245
2.96k
source
stringlengths
38
44
__index_level_0__
int64
18
2.25M
1,461,321
In 1957, a male child was born with poor mental development, repeated attacks of acidosis, and high levels of ketones and glycine in the blood. Upon dietary testing, Dr. Barton Childs discovered that his symptoms worsened when given the amino acids leucine, isoleucine, valine, methionine, and threonine. In 1961, the medical team at Johns Hopkins Hospital in Baltimore, Maryland published the case, calling the disorder ketotic hyperglycinemia. In 1969, using data from the original patient's sister, scientists established that propionic acidemia was a recessive disorder, and that propionic acidemia and methylmalonic acidemia are caused by deficiencies in the same enzyme pathway.
https://en.wikipedia.org/wiki?curid=549792
1,460,499
1,737,848
Surgery is not always an option when the anatomy of the malformation creates too much of a risk. Recent improvements in endovascular procedures have made many cases, which were not surgically accessible, treatable. Endovascular treatments involve delivering drugs, balloons, or coils to the site of the malformation through blood vessels via catheters. These treatments work by limiting blood flow through the vein. There is, however, still risk of complications from endovascular treatments. The wall of the vein can be damaged during the procedure and, in some cases, the emboli can become dislodged and travel through the vascular system. Two-dimensional echocardiography with color-flow imaging and pulsed Doppler ultrasound was used to evaluate one fetus and five neonates with a Vein of Galen malformation. Color-flow imaging and pulsed Doppler ultrasonography provided anatomical and pathophysiological information regarding cardiac hemodynamics and intracranial blood flow; with the patient's clinical status, these methods provided a reliable, noninvasive means to evaluate the effectiveness of therapy and the need for further treatment in neonates with Vein of Galen malformations. When none of these procedures are viable, shunting can be used to ameliorate the pressure inside the varix. Seizures usually are managed with antiepileptic medications.
https://en.wikipedia.org/wiki?curid=27119200
1,736,871
265,278
Karem Aircraft proposed to design an optimum-speed tiltrotor (OSTR), designated the TR36TD demonstrator. It would have had twin variable-speed rotors powered by existing turboshaft engines. The production version of the TR36D would have had a level flight speed of . Karem says its variable-speed OSTR configuration offers advantages in weight, drive train, and aerodynamic and propulsive efficiency. It has high speed, "robust" hover performance at altitude, higher climb rate and sustained maneuverability, and longer range than other vertical-takeoff-and-landing configurations. They also say it offers reduced complexity, inherent safety advantages, simplified maintenance, and low total ownership cost. , Karem continues to work on versions of the TR36, intending to start testing rotors around 2018.
https://en.wikipedia.org/wiki?curid=29347958
265,135
1,403,833
A deep learning system was reported to learn intuitive physics from visual data (of virtual 3D environments) based on an unpublished approach inspired by studies of visual cognition in infants.<ref name="10.1038/s41562-022-01394-8"></ref> Other researchers have developed a machine learning algorithm that could discover sets of basic variables of various physical systems and predict the systems' future dynamics from video recordings of their behavior.<ref name="advancedsciencenews.com/an-artific"></ref> In the future, it may be possible that such can be used to automate the discovery of physical laws of complex systems. Beyond discovery and prediction, "blank slate"-type of learning of fundamental aspects of the physical world may have further applications such as improving adaptive and broad artificial general intelligence. In specific, prior machine learning models were "highly specialised and lack a general understanding of the world".
https://en.wikipedia.org/wiki?curid=61373032
1,403,043
1,500,490
Köchler has been the organizer of major international conferences in the fields of transnational co-operation, democracy, human rights, terrorism, and conflict resolution, among them the "International Conference on the European Vocation of the Alpine Region" in Innsbruck (1971), which initiated transborder co-operation in Europe and the development towards the "Euro Regions" within the EU; the "International Conference on the Question of Terrorism" in Geneva (1987); and the "Second International Conference On A More Democratic United Nations" (CAMDUN-2) at the Vienna headquarters of the United Nations (1991). In 1996 he acted as chairman of the final session and co-ordinator of the Drafting Committee of the "International Conference on Democracy and Terrorism" in New Delhi. In March 2002 he delivered the 14th Centenary Lecture at the Supreme Court of the Philippines on "The United Nations, the International Rule of Law and Terrorism." On 1 September 2004 he delivered the Foundation Day Speech at Mindanao State University, Islamic City of Marawi, on "The Dialogue of Civilizations and the Future of World Order."
https://en.wikipedia.org/wiki?curid=3810935
1,499,645
308,381
There has been concern over interference between narrowband and UWB signals that share the same spectrum. Earlier, the only radio technology that used pulses was spark-gap transmitters, which international treaties banned because they interfere with medium-wave receivers. However, UWB uses much lower levels of power. The subject was extensively covered in the proceedings that led to the adoption of the FCC rules in the US, and in the meetings of the ITU-R leading to its Report and Recommendations on UWB technology. Commonly-used electrical appliances emit impulsive noise (for example, hair dryers), and proponents successfully argued that the noise floor would not be raised excessively by wider deployment of low power wideband transmitters.
https://en.wikipedia.org/wiki?curid=166428
308,216
1,387,693
Along with Greenpeace, WWF, Spanish energy companies and the regional authority of Galicia, ClientEarth has intervened regarding the European Commission's decision to approve subsidies to the Spanish coal industry. The approved plan gives preferential access to the wholesale electricity market in Spain for power plants that run on domestic coal. Spanish electricity utilities, including Gas Natural, Iberdrola and Endesa have claimed that this will force them to withdraw from contracts for cheaper imported coal and buy more expensive, lower-quality domestic coal, while the parties have also argued that the decision breaches European laws on state aid and the environment, and that the Spanish government aid will unfairly skew the European energy market. ClientEarth also expressed concern that, if the decision was allowed to stand, other countries may be tempted to use similar tactics to bolster their coal sectors. They and the other environmental groups rejected Spain's position that it was attempting to protect the nation's energy security, arguing that the country has an oversupply of natural gas and, at times, renewable energy.
https://en.wikipedia.org/wiki?curid=30896727
1,386,926
1,563,020
On 26 Dec 2004, there was a great tsunami striking the coasts of most landmasses bordering the Indian Ocean, killing more than 225,000 people in eleven countries. It was one of the deadliest natural disasters in history. Indonesia, Sri Lanka, India, and Thailand were among approximately 14 countries to experience the death of thousands of locals and tourists. After the propagation of the sorrowful news, people around the world initiated donation campaigns immediately. Besides donations from governments, the public donated at the same time. For example, in the first few days, British donated 1 million pounds. Overall, the public around the world donated US$470 million. The sight of victims in media caused negative emotion, like the sadness over deaths, on the donors. Therefore, their donation helped reduce these negative feelings according to the model.
https://en.wikipedia.org/wiki?curid=20222724
1,562,133
1,613,970
The break-up of Gondwana left the resulting continents, including Zealandia, with a shared ecology. Zealandia began to move away from the part of Gondwana which would become Australia and Antarctica approximately 85 million years ago (Ma). By about 70 Ma, the break up was complete. Zealandia has been moving northwards ever since, changing both in relief and climate. Most of the present biota of New Zealand has post-Gondwanan connections to species on other landmasses, but does include a few descendants of Gondwanan lineages, such as the Saint Bathans mammal. Overall, trans-oceanic dispersal has played a clear role in the formation of New Zealand's biota. Several elements of Gondwana biota are present in New Zealand today: predominantly plants, such as the podocarps and the southern beeches, but also distinctive insects, birds, frogs and the tuatara.
https://en.wikipedia.org/wiki?curid=15089769
1,613,065
955,659
Neuroscientists generally work as researchers within a college, university, government agency, or private industry setting. In research-oriented careers, neuroscientists typically spend their time designing and carrying out scientific experiments that contribute to the understanding of the nervous system and its function. They can engage in basic or applied research. Basic research seeks to add information to our current understanding of the nervous system, whereas applied research seeks to address a specific problem, such as developing a treatment for a neurological disorder. Biomedically-oriented neuroscientists typically engage in applied research. Neuroscientists also have a number of career opportunities outside the realm of research, including careers in industry, science writing, government program management, science advocacy, and education. These individuals most commonly hold doctorate degrees in the sciences, but may also hold a master's degree.
https://en.wikipedia.org/wiki?curid=665536
955,154
387,103
In his book "The New Economics for Industry, Government, and Education" Deming championed the work of Walter Shewhart, including statistical process control, operational definitions, and what Deming called the "Shewhart Cycle," which had evolved into Plan-Do-Check-Act (PDCA). Deming is best known for his work in Japan after WWII, particularly his work with the leaders of Japanese industry. That work began in July and August 1950, in Tokyo and at the Hakone Convention Center, when Deming delivered speeches on what he called "Statistical Product Quality Administration". Many in Japan credit Deming as one of the inspirations for what has become known as the Japanese post-war economic miracle of 1950 to 1960, when Japan rose from the ashes of war on the road to becoming the second-largest economy in the world through processes partially influenced by the ideas Deming taught:
https://en.wikipedia.org/wiki?curid=70534
386,908
1,073,789
Iproniazid was originally developed for the treatment of tuberculosis, but in 1952, its antidepressant properties were discovered when researchers noted that patients became inappropriately happy when given isoniazid, a structural analog of iproniazid. Subsequently N-isopropyl addition led to development as an antidepressant and was approved for use in 1958. It was withdrawn in most of the world a few years later in 1961 due to a high incidence of hepatitis, and was replaced by less hepatotoxic drugs such as phenelzine and isocarboxazid. Canada surprisingly withdrew iproniazid in July 1964 due to interactions with food products containing tyramine. Nevertheless, iproniazid has historic value as it helped establish the relationship between psychiatric disorders and the metabolism of neurotransmitters.
https://en.wikipedia.org/wiki?curid=2951507
1,073,235
1,374,026
Grew was the only son of Obadiah Grew (1607–1688), Nonconformist divine and vicar of St Michaels, Coventry, and was born in Warwickshire. He graduated at Pembroke College, Cambridge in 1661, and ten years later took the degree of MD at Leiden University, his thesis being "Disputatio medico-physica de liquore nervoso". He began observations on the anatomy of plants in 1664, and in 1670 his essay, "The Anatomy of Vegetables begun", was communicated to the Royal Society by Bishop Wilkins, on whose recommendation he was in the following year elected a fellow. In 1672, when the essay was published, he settled in London, and soon acquired an extensive practice as a physician. In 1673 he published his "Idea of a Phytological History", which consisted of papers he had communicated to the Royal Society in the preceding year, and in 1677 he succeeded Henry Oldenburg as secretary of the society. He edited the "Philosophical Transactions" in 1678–1679, and in 1681 he published by request a descriptive catalogue of the rarities preserved at Gresham College, with which were printed some papers he had read to the Royal Society on the "Comparative Anatomy of Stomachs and Guts".
https://en.wikipedia.org/wiki?curid=476465
1,373,268
2,235,774
Wayne State was to begin its 13th season of women’s ice hockey on September 30, 2011. In its twelve existing seasons, the Warriors compiled a won-loss record of 138-209-29 (.406 winning percentage). In College Hockey America conference play, the program accumulated an all-time CHA mark of 48-59-7 (.452) in nine seasons. In 2007-08, Wayne State tied for the CHA regular-season title in 2007-08. Senior forward Alyssa Baldin was to serve as captain for the second consecutive year. Of note, Baldin was the Warriors active scoring leader (while ranking seventh all-time in career points). Wayne State was the only Division I women’s program in Michigan.
https://en.wikipedia.org/wiki?curid=33106149
2,234,504
1,807,187
Nanoparticles can also be used in conjunction with DNA to perform genetic alterations. These are frequently monitored through the use of fluorescent materials, allowing scientists to judge if these tagged proteins have successfully been transmitted—for example green fluorescent protein, or GFP. Nanoparticles are significantly less cytotoxic than currently used organic methods, providing a more efficient method of monitoring genetic alternations. They also do not degrade or bleach with time, as organic dyes do. Suspensions of nanoparticles with the same size and shapes (mono-dispersed) with functional groups attached to their surfaces can also electrostatically bind to DNA, protecting them from several types of degradation. Because the fluorescence of these nanoparticles does not degrade, cellular localization can be tracked without the use of additional tagging, with GFPs or other methods. The 'unpacking' of the DNA can be detected in live cells using luminescence resonance energy transfer (LRET) technology.
https://en.wikipedia.org/wiki?curid=31726766
1,806,168
134,906
The limitation that Diamond admits in her study is that she had only one Einstein to compare with 11 brains of normal intelligence individuals. S. S. Kantha of the Osaka Bioscience Institute criticized Diamond's study, as did Terence Hines of Pace University. Other issues related to Diamond's study point out glial cells continue dividing as a person ages and although Einstein's brain was 76, it was compared to brains that averaged 64 in age (eleven male brains, 47–80 years of age). Diamond in her landmark study "On the Brain of a Scientist: Albert Einstein" noted that the 11 male individuals whose brains were used in her control base had died from nonneurologically related diseases. She also noted that "Chronological age is not necessarily a useful indicator in measuring biological systems. Environmental factors also play a strong role in modifying the conditions of the organism. One major problem in dealing with human specimens is that they do not come from controlled environments."
https://en.wikipedia.org/wiki?curid=3627193
134,851
1,176,168
Clinical measurement of cardiac output has been available since the 1970s. However, this blood flow measurement is highly invasive, utilizing a flow-directed, thermodilution catheter (also known as the Swan-Ganz catheter), which represents significant risks to the patient. In addition, this technique is costly (several hundred dollars per procedure) and requires a skilled physician and a sterile environment for catheter insertion. As a result, it has been used only in very narrow strata (less than 2%) of critically ill and high-risk patients in whom the knowledge of blood flow and oxygen transport outweighed the risks of the method. In the United States, it is estimated that at least two million pulmonary artery catheter monitoring procedures are performed annually, most often in peri-operative cardiac and vascular surgical patients, decompensated heart failure, multi-organ failure, and trauma.
https://en.wikipedia.org/wiki?curid=5312299
1,175,546
238,026
Genetic screening for Down syndrome (trisomy 21) and Edwards syndrome (trisomy 18), the national standard in the United States, is rapidly evolving away from the AFP-quad screen, done typically in the second trimester at 16–18 weeks. The newer integrated screen (formerly called F.A.S.T.E.R for First And Second Trimester Early Results) can be done at 10 plus weeks to 13 plus weeks with an ultrasound of the fetal neck (thicker nuchal skin correlates with higher risk of Down syndrome being present) and two chemicals (analytes), pregnancy-associated plasma protein A and human chorionic gonadotropin (pregnancy hormone level itself). It gives an accurate risk profile very early. A second blood screen at 15 to 20 weeks refines the risk more accurately. The cost is higher than an "AFP-quad" screen due to the ultrasound and second blood test, but it is quoted to have a 93% pick up rate as opposed to 88% for the standard AFP/QS. This is an evolving standard of care in the United States.
https://en.wikipedia.org/wiki?curid=52965
237,907
1,430,619
Dressed in the traditional Russian black cassock, with his long hair a beard often described as 'Christ-like', Feodorov was a man of the "narod", of the ordinary Russian people for whom the Revolution had been fought. His presence put the lie to the usual description of Catholicism as 'the Polish religion.' His presentation -- a moving testimony of Russian spirituality and the history of the Church in that country -- evoked the best of Russian Christendom. He pointed out that Greek-Catholics greeted the Revolution with joy, for only then did they have equality. There was no secret organization, they had simply followed Church law. Religious education, the celebration of Mass, and the administration of the Sacraments of marriage and baptism had to be fulfilled. He pointed out that the Church, accused of having neglected the starving, was at that moment feeding 120,000 children daily. Following a scathing rebuttal by Krylenko, Exarch Feodorov rose for his final remarks: "Our hearts are full, not of hatred, but of sadness. You cannot understand us, we are not allowed liberty of conscience. That is the only conclusion we can draw from what we have heard here."
https://en.wikipedia.org/wiki?curid=5014963
1,429,815
99,453
Macular degeneration is especially prevalent in the U.S. and affects roughly 1.75 million Americans each year. Having lower levels of lutein and zeaxanthin within the macula may be associated with an increase in the risk of age-related macular degeneration. < Lutein and zeaxanthin act as antioxidants that protect the retina and macula from oxidative damage from high-energy light waves. As the light waves enter the eye they excite electrons that can cause harm to the cells in the eye, but they can cause oxidative damage that may lead to macular degeneration or cataracts. Lutein and zeaxanthin bind to the electron free radical and are reduced rendering the electron safe. There are many ways to ensure a diet rich in lutein and zeaxanthin, the best of which is to eat dark green vegetables including kale, spinach, broccoli and turnip greens. Nutrition is an important aspect of the ability to achieve and maintain proper eye health. Lutein and zeaxanthin are two major carotenoids, found in the macula of the eye, that are being researched to identify their role in the pathogenesis of eye disorders such as age-related macular degeneration and cataracts.
https://en.wikipedia.org/wiki?curid=1070221
99,410
158,532
Toyota originally began sharing TPS with its parts suppliers in the 1990s. Because of interest in the program from other organizations, Toyota began offering instruction in the methodology to others. Toyota has even "donated" its system to charities, providing its engineering staff and techniques to non-profits in an effort to increase their efficiency and thus ability to serve people. For example, Toyota assisted the Food Bank For New York City to significantly decrease waiting times at soup kitchens, packing times at a food distribution center, and waiting times in a food pantry. Toyota announced on June 29, 2011 the launch of a national program to donate its Toyota Production System expertise towards nonprofit organizations with goal of improving their operations, extending their reach, and increasing their impact. By September, less than three months later, SBP, a disaster relief organization based out of New Orleans, reported that their home rebuilds had been reduced from 12 to 18 weeks, to 6 weeks. Additionally, employing Toyota methods (like "kaizen") had reduced construction errors by 50 percent. The company included SBP among its first 20 community organizations, along with AmeriCorps.
https://en.wikipedia.org/wiki?curid=342815
158,451
468,288
The size of today's subsea permafrost has been estimated at 2 million km (~1/5 of the terrestrial permafrost domain size), which constitutes a 30-50% reduction since the LGM. Containing around 560 GtC in OM and 45 GtC in CH, with a current release of 18 and 38 MtC per year respectively, which is due to the warming and thawing that the subsea permafrost domain has been experiencing since after the LGM (~14000 years ago). In fact, because the subsea permafrost systems responds at millennial timescales to climate warming, the current carbon fluxes it is emitting to the water are in response to climatic changes occurring after the LGM. Therefore, human-driven climate change effects on subsea permafrost will only be seen hundreds or thousands of years from today. According to predictions under a business-as-usual emissions scenario RCP 8.5, by 2100, 43 GtC could be released from the subsea permafrost domain, and 190 GtC by the year 2300. Whereas for the low emissions scenario RCP 2.6, 30% less emissions are estimated. This constitutes a significant anthropogenic-driven acceleration of carbon release in the upcoming centuries.
https://en.wikipedia.org/wiki?curid=13294262
468,053
1,687,826
The size of today's subsea permafrost has been estimated at around 2 million km (~1/5 of the terrestrial permafrost domain size), which constitutes a 30-50% reduction since the LGM. Containing around 560 GtC in OM and 45 GtC in CH, with a current release of 18 and 38 MtC per year respectively, which is due to the warming and thawing that the subsea permafrost domain has been experiencing since after the LGM (~14000 years ago). In fact, because the subsea permafrost systems responds at millennial timescales to climate warming, the current carbon fluxes it is emitting to the water are in response to climatic changes occurring after the LGM. Therefore, human-driven climate change effects on subsea permafrost will only be seen hundreds or thousands of years from today. According to predictions under a business-as-usual emissions scenario RCP 8.5, by 2100, 43 GtC could be released from the subsea permafrost domain, and 190 GtC by the year 2300. Whereas for the low emissions scenario RCP 2.6, 30% less emissions are estimated. This constitutes a significant anthropogenic-driven acceleration of carbon release in the upcoming centuries.
https://en.wikipedia.org/wiki?curid=27167234
1,686,880
1,281,828
At the end of a day's march, the Romans would typically establish a strong field camp called a castra, complete with palisade and a deep ditch, providing a basis for supply storage, troop marshalling and defence. Streets were laid out, units designated to take specific places, and guards posted at carefully designed gates. Construction could take between 2 and 5 hours with part of the army laboring, while the rest stood guard, depending on the tactical situation. No other ancient army persisted over such a long period in systematic camp construction like the Romans, even if the army rested for only a single day. This concentration of conservative security in deployment was mirrored both in the measured tactics of engagement for the infantry and by the largely conservative operational strategies employed.
https://en.wikipedia.org/wiki?curid=8049650
1,281,132
436,187
After Despradelle's sudden death in 1912, Freeman's "Study No. 7" was thrust to the fore. His proposal, based on Taylorism, was "one-fifth architecture and four-fifths a problem of industrial engineering." He proposed connecting all departmental buildings to prevent the emergence of academic fiefdoms, to provide protection from bad weather, and to enable efficiencies of scale by building a massive, one million square-foot building incorporating the administrative, teaching, and research functions. The proposed five-story building resembled a large "E" with the base aligned to the river, with "cloistered" courtyards and a pedimented Doric exterior. Freeman also rejected using masonry walls, and proposed using reinforced concrete, a relatively new material that was then thought to be both expensive and unconventional.
https://en.wikipedia.org/wiki?curid=8071866
435,973
218,220
However, instead of translating "POW"<nowiki></nowiki>'s proposals into institutional plans for transformation, Wits reacted in a defensive manner and refused to even acknowledge many of the criticisms that had been raised. Within the university community the perception was different—it was felt that Wits was on the right track. The contradiction between internal and external perceptions would increasingly undermine the unity of the university community, as progressive elements on campus began to take more radical positions in opposition to apartheid. Internal debates about, among other things, the international academic boycott of South Africa and the role of academics in the anti-apartheid struggle led to increasing division within the university. University management was increasingly seen as isolated and out of touch, and began to be referred to by the metonym "the eleventh floor", referring to the eleventh floor of Senate House where top management at Wits is located.
https://en.wikipedia.org/wiki?curid=320467
218,112
1,325,335
Before the smelter was constructed, the company knew the smoke and fumes would be an issue, and the lead emissions were a health risk. In the words of the Public Health Service surgeon, Dr. Royd R. Sayers, written in 1918, "Whoever works in or about a lead smelter may become leaded." Yet, the 1924 Idaho Industrial Accident Board stated lead poisoning was an occupational disease not eligible for compensation. In other words, the miners assumed the risk by choosing to work. The company did have a compensation plan for victims, and implemented a Clauge electrolytic treatment in 1919, and a solarium in 1929. In an effort to reduce particles, the company installed a 14-unit Frederick Cottrell electrostatic precipitator, and 2800-bag baghouse to capture dust. In 1936, the company added an Impinger dust collector and an Owens jet-dust counter.
https://en.wikipedia.org/wiki?curid=32086133
1,324,608
1,765,870
Studying the female reproductive tract, especially in humans, allows for a better understanding of the immune system, including during pregnancy. However, studying the female reproductive tract has been a challenging area of research due to existing limitations in the in vitro and in vivo tools available. Ethical concerns is another contributing factor in hindering the study of reproductive immunology. Given such limitations, research in this field relies on stem cell culture and technological advancements by allowing scientists to conduct research on organoids instead of living human subjects. In 2018, a Review study concluded that organoids can be used to model organ development and disease. Other studies have concluded that with further technological advancements, it is possible to create a detailed 3D organoid model of the female reproductive tract which introduces a more efficient method to conduct research and collect data in the fields of drug discovery, basic research and essentially reproductive immunology.
https://en.wikipedia.org/wiki?curid=22827348
1,764,877
1,597,108
In 2020, Jackson was one of several academics who took a public position on racism in the New Zealand health sector. He co-authored an article in the New Zealand Medical Journal that defined systematic racism in terms of how it affected health for marginalised populations by inequitable access to services, prejudice and internalisation by this population of negative messages about their worth and right to equitable services. The article also highlighted "false beliefs" that were claimed contributed to ongoing racism within the health sector in Aotearoa New Zealand and used examples of these in research in which they had explored "differences in cardiovascular disease (CVD) risk factors and outcomes by ethnicity." Following publication of the article, feedback from three reviewers was provided by the New Zealand Medical Journal to the authors, who challenged what they claimed were "racist comments" in the feedback. While it was acknowledged by the authors that they had been given the opportunity to address the comments through the peer review process, they made the case that the editorial process followed by the NZMJ was an example of systemic racism. Reasons they gave for this included an apparent lack of expertise of the reviewers, equal treatment of all comments without any filter on whether they were racist, and that the responses to the racist comments were "sent back to the reviewers who had made those comments (along with our responses to their other comments), which led to further racist comments to which our team were again unnecessarily exposed and to which we again had to respond."
https://en.wikipedia.org/wiki?curid=69753744
1,596,209
1,013,157
Prior to this, there had been failed synthesis attempts in 1986–87 at the Joint Institute for Nuclear Research in Dubna (then in the Soviet Union) and in 1990 at the GSI. A 1995 attempt at the Lawrence Berkeley National Laboratory resulted in signs suggesting but not pointing conclusively at the discovery of a new isotope formed in the bombardment of with , and a similarly inconclusive 1994 attempt at the JINR showed signs of being produced from and . Each team proposed its own name for element 110: the American team proposed "hahnium" after Otto Hahn in an attempt to resolve the controversy of naming element 105 (which they had long been suggesting this name for), the Russian team proposed "becquerelium" after Henri Becquerel, and the German team proposed "darmstadtium" after Darmstadt, the location of their institute. The IUPAC/IUPAP Joint Working Party (JWP) recognised the GSI team as discoverers in their 2001 report, giving them the right to suggest a name for the element.
https://en.wikipedia.org/wiki?curid=40163
1,012,636
1,214,994
In December 2011, a research group at MIT reported a combined implementation of the laser (stroboscopic) and streak camera applications to capture images of a repetitive event that can be reassembled to create a trillion-frame-per-second video. This rate of image acquisition, which enables the capture of images of moving photons, is possible by the use of the streak camera to collect each field of view rapidly in narrow single streak images. Illuminating a scene with a laser that emits pulses of light every 13 nanoseconds, synchronized to the streak camera with repeated sampling and positioning, researchers have demonstrated collection of one-dimensional data which can be computationally compiled into a two-dimensional video. Although this approach is limited by time resolution to repeatable events, stationary applications such as medical ultrasound or industrial material analysis are possibilities.
https://en.wikipedia.org/wiki?curid=3582572
1,214,342
1,517,840
Many experiments of the Max-Planck-Institut für extraterrestrische Physik (MPE) have to be carried out above the dense Earth's atmosphere using aircraft, rockets, satellites and space probes. In the early days experiments were also flown on balloons. To run advanced extraterrestrial physics and state-of-the-art experimental astrophysics, the institute continues to develop high-tech instrumentation in-house. This includes detectors, spectrometers, and cameras as well as telescopes and complete payloads (e.g. ROSAT and eROSITA) and even entire satellites (as in case of AMPTE and EQUATOR-S). For this purpose the technical and engineering departments are of particular importance for the institute's research work.
https://en.wikipedia.org/wiki?curid=614798
1,516,988
1,487,434
BIRCH (balanced iterative reducing and clustering using hierarchies) is an algorithm used to perform connectivity-based clustering for large data-sets. It is regarded as one of the fastest clustering algorithms, but it is limited because it requires the number of clusters as an input. Therefore, new algorithms based on BIRCH have been developed in which there is no need to provide the cluster count from the beginning, but that preserves the quality and speed of the clusters. The main modification is to remove the final step of BIRCH, where the user had to input the cluster count, and to improve the rest of the algorithm, referred to as tree-BIRCH, by optimizing a threshold parameter from the data. In this resulting algorithm, the threshold parameter is calculated from the maximum cluster radius and the minimum distance between clusters, which are often known. This method proved to be efficient for data sets of tens of thousands of clusters. If going beyond that amount, a supercluster splitting problem is introduced. For this, other algorithms have been developed, like MDB-BIRCH, which reduces super cluster splitting with relatively high speed.
https://en.wikipedia.org/wiki?curid=58475368
1,486,596
544,622
On February 20, 2018, Vice President Mike Pence, Chairman of the National Space Council announced the candidates selected to serve on the National Space Council Users Advisory Group. Pending official appointment by the Administrator of the National Aeronautics and Space Administration, the selected members of the Users Advisory Group will serve to fulfill President Trump's mandate to "foster close coordination, cooperation, and technology and information exchange" across our nation's space enterprise. The announcement was made on the eve of the second meeting of the National Space Council. "Moon, Mars, and Worlds Beyond: Winning the Next Frontier" includes testimonials from leaders in the civil, commercial, and national security sectors about the importance of the United States' space enterprise. NSC UAG consists of six subcommittees. Details are at nasa.gov With detailed reports of meetings at FederalRegister.gov. and the most recent meeting agenda booklet
https://en.wikipedia.org/wiki?curid=18716701
544,340
612,804
Lorentz (1892a) set the foundations of Lorentz aether theory, by assuming the existence of electrons which he separated from the aether, and by replacing the "Maxwell–Hertz" equations by the "Maxwell–Lorentz" equations. In his model, the aether is completely motionless and, contrary to Fresnel's theory, also is not partially dragged by matter. An important consequence of this notion was that the velocity of light is totally independent of the velocity of the source. Lorentz gave no statements about the mechanical nature of the aether and the electromagnetic processes, but, rather, tried to explain the mechanical processes by electromagnetic ones and therefore created an abstract electromagnetic æther. In the framework of his theory, Lorentz calculated, like Heaviside, the contraction of the electrostatic fields. Lorentz (1895) also introduced what he called the "Theorem of Corresponding States" for terms of first order in formula_3. This theorem states that a moving observer (relative to the aether) in his "fictitious" field makes the same observations as a resting observer in his "real" field. An important part of it was local time formula_2, which paved the way to the Lorentz transformation and which he introduced independently of Voigt. With the help of this concept, Lorentz could explain the aberration of light, the Doppler effect and the Fizeau experiment as well. However, Lorentz's local time was only an auxiliary mathematical tool to simplify the transformation from one system into another – it was Poincaré in 1900 who recognized that "local time" is actually indicated by moving clocks. Lorentz also recognized that his theory violated the principle of action and reaction, since the aether acts on matter, but matter cannot act on the immobile aether.
https://en.wikipedia.org/wiki?curid=1790788
612,493
452,994
This led to the possibility of making a memory system similar to the moving-domain twistor concept, but using a single block of magnetic material instead of many twistor wires. Starting work extending this concept using orthoferrite, Bobeck noticed an additional interesting effect. With the magnetic tape materials used in twistor, the data had to be stored on relatively large patches known as "domains". Attempts to magnetize smaller areas would fail. With orthoferrite, if the patch was written and then a magnetic field was applied to the entire material, the patch would shrink down into a tiny circle, which he called a "bubble". These bubbles were much smaller than the domains of normal media like tape, which suggested that very high area densities were possible.
https://en.wikipedia.org/wiki?curid=163097
452,773
1,713,219
International relief targeted at poverty reduction could also be redirected towards subsidizing renewable energy projects. Because of the integral role that electrification plays in supporting economic and social development, funding of rural electrification can be seen as the core method for addressing poverty. Radios, televisions, telephones, computer networks, and computers all rely on an access to electricity. Because information services allow for the proliferation of education resources, funding the electric backbone to such systems has a derivative effect on their development. In this way, access to communications and education plays a major role in reducing poverty. Additionally, international efforts that supply equipment and services rather than money, are more resistant to resource misappropriation issue that pose problems in less stable governments.
https://en.wikipedia.org/wiki?curid=11492908
1,712,253
772,026
Flaps may be fully extended for landing to give the aircraft a lower stall speed so the approach to landing can be flown more slowly, which also allows the aircraft to land in a shorter distance. The higher lift and drag associated with fully extended flaps allows a steeper and slower approach to the landing site, but imposes handling difficulties in aircraft with very low wing loading (i.e. having little weight and a large wing area). Winds across the line of flight, known as "crosswinds", cause the windward side of the aircraft to generate more lift and drag, causing the aircraft to roll, yaw and pitch off its intended flight path, and as a result many light aircraft land with reduced flap settings in crosswinds. Furthermore, once the aircraft is on the ground, the flaps may decrease the effectiveness of the brakes since the wing is still generating lift and preventing the entire weight of the aircraft from resting on the tires, thus increasing stopping distance, particularly in wet or icy conditions. Usually, the pilot will raise the flaps as soon as possible to prevent this from occurring.
https://en.wikipedia.org/wiki?curid=1002551
771,612
880,411
Jackson and Berry (1979) and Ungricht et al. (1998) have documented the subsequent confusion over the number of Mediterranean species of "Mandragora" and their scientific names. Dioscorides was among those who distinguished between "male" and "female" mandrakes, a distinction used in 1764 when Garsault published the names "Mandragora mas" and "Mandragora foemina". The size and shape of the fruit and the colour and time of appearance of the flowers have been used to distinguish possible species. In the 1820s, Antonio Bertoloni used flowering time to name two species as "Mandragora vernalis", the spring-flowering mandrake, and "Mandragora autumnalis", the autumn-flowering mandrake. Identifying the former as Linnaeus's "M. officinarum", works such as "Flora Europaea" listed two Mediterranean species of "Mandragora": "M. officinarum" and "M. autumnalis". Using statistical analysis of morphological characters, Ungricht et al. found no distinct clusters among the specimens they examined and concluded that Linnaeus's "M. officinarum" is a single, variable species. Other sources divide "M. officinarum" "sensu lato" differently. Plants from the western Mediterranean, from Turkey westwards to the Iberian peninsula and Morocco, are placed in "M. officinarum"; plants from the eastern Mediterranean, from Syria to Israel, are placed in "M. autumnalis".
https://en.wikipedia.org/wiki?curid=46222073
879,947
653,036
An amateur scientist, Foote conducted a series of experiments that demonstrated the interactions of sunlight on different gases. She used an air pump, two glass cylinders, and four mercury-in-glass thermometers. In each cylinder, she placed two thermometers and then used the pump to evacuate the air from one cylinder and compress it in the other cylinder. When both cylinders reached equal ambient temperatures, they were placed in the sunlight and temperature variances were measured. She also placed the containers in the shade for comparison and tested the temperature results by dehydrating one cylinder and adding water to the other, to measure the effect of dry versus moist air. Foote noted that the amount of moisture in the air impacted the temperature results. She performed this experiment on air, carbon dioxide () (which was called carbonic acid gas in her era), and hydrogen, finding that the tube filled with carbon dioxide became hotter than the others when exposed to sunlight. She wrote: "The receiver containing this gas became itself much heated—very sensibly more so than the other—and on being removed [from the Sun], it was many times as long in cooling".
https://en.wikipedia.org/wiki?curid=49280323
652,693
1,916,982
In the Middle Ages, Galenic anatomo-physiology prevailed as the leading medical thought. Furthermore, Aristotelian natural philosophy had dominated for centuries, including the humoral system as a primary method of medical thought. However, the philosophies of Aristotle, Hippocrates, and Galen began to wane in popularity, replaced by anatomical and philosophical schools of thought based on mechanics and chemical naturalism. Ideologies such as iatrophysics and iatrochemistry began to prevail. The decline of Galenic philosophy-based medicine coupled with the rise of new ideologies was spurred by the advent of new discoveries in anatomy and physiology, such as that of William Harvey's work centered on circulation of the blood. His idea that pulse, respiration, and nutrition were all working components of a unified system revolutionized preexisting ideas about blood, nutrition, and heat. The discovery of the circulation of the blood was crucial in the development of iatrophysics in that it was the first that related “circulations” to physiological functions. This led to the advent of new discoveries such as the circulation of nutritive fluid, circulation of lymph, and circulation of nervous juice, all of which relate a machine-like mechanism to anatomy.
https://en.wikipedia.org/wiki?curid=10512779
1,915,883
610,986
Deep neural networks can be potentially improved by deepening and parameter reduction, while maintaining trainability. While training extremely deep (e.g., 1 million layers) neural networks might not be practical, CPU-like architectures such as pointer networks and neural random-access machines overcome this limitation by using external random-access memory and other components that typically belong to a computer architecture such as registers, ALU and pointers. Such systems operate on probability distribution vectors stored in memory cells and registers. Thus, the model is fully differentiable and trains end-to-end. The key characteristic of these models is that their depth, the size of their short-term memory, and the number of parameters can be altered independently.
https://en.wikipedia.org/wiki?curid=28016652
610,675
1,413,965
These characteristics suggest that carbon nanotubes are a potential substitute for silicon with regards to CNTFETs and logic circuits. But CNTFETs cannot (yet) be mass manufactured, and therefore carbon nanotube processors cannot either, and both are currently limited to research facilities where they are manually assembled. The first carbon nanotube computer was built in 2013 by researchers at Stanford University. This one-bit processor, named Cedric, ran at 1KHz and contained just 178 transistors. Since then, many research teams have built increasingly complex processors with CNTFETs. In 2019, a team of engineers from the Massachusetts Institute of Technology and Analog Devices created a programmable 16-bit, ~15,000-transistor processor called the RV16X-NANO.
https://en.wikipedia.org/wiki?curid=40636816
1,413,169
29,492
Philosophy – Alexandria acted as a melting pot for philosophies of Pythagoreanism, Platonism, Stoicism and Gnosticism which formed the origin of alchemy's character. An important example of alchemy's roots in Greek philosophy, originated by Empedocles and developed by Aristotle, was that all things in the universe were formed from only four elements: earth, air, water, and fire. According to Aristotle, each element had a sphere to which it belonged and to which it would return if left undisturbed. The four elements of the Greek were mostly qualitative aspects of matter, not quantitative, as our modern elements are; "...True alchemy never regarded earth, air, water, and fire as corporeal or chemical substances in the present-day sense of the word. The four elements are simply the primary, and most general, qualities by means of which the amorphous and purely quantitative substance of all bodies first reveals itself in differentiated form." Later alchemists extensively developed the mystical aspects of this concept.
https://en.wikipedia.org/wiki?curid=573
29,482
1,056,857
Space mirrors were also proposed at the "Response Options to Rapid or Severe Climate Change" round-table meeting organized by the President's Climate Change Technology Program in September 2001. Lowell Wood, a senior staff scientist at the Lawrence Livermore National Laboratory proposed stationing one or more wire-mesh "mirrors" in orbit to deflect sunlight back into space or to filter it. Wood calculated that deflecting 1% of sunlight would restore climatic stability, and that would require either a single mirror 600,000 square miles (1,600,000 km) in area or several smaller ones. Wood had been researching the idea for more than ten years but considered it so infeasible that it should only be a back-up plan for solving the global warming problem.
https://en.wikipedia.org/wiki?curid=27271259
1,056,308
1,231,527
Laban's first book on the subject was published in German in 1928 called Schrifttanz (Written Dance); a similar version in French and English appeared in 1930. A few years later Laban's interest turned to other matters and he gave his notation system to the world. The German dancer, choreographer and pedagogue Albrecht Knust, who by 1930 had together with Laban's daughter Azra (Azraela) established the "Tanz-Schreib-Stube" (the first Dance Notation Bureau), was the first-ever full-time kinetographer-movement notator. Between 1946-1950 Knust wrote his major work Das Handbuch der Kinetographie Laban (The Manual of Kinetography Laban) in eight-volumes in German, typed carbon copies appeared in 1951 in English. Ann Hutchinson Guest and former student of Sigurd Leeder, studied the system differences among and between the various practitioners taught by former Laban student Irma Betz, and had the opportunity to confer with Laban, Knust and Leeder personally on movement details and ideas, developed it further naming it Labanotation. The two systems differ somewhat.
https://en.wikipedia.org/wiki?curid=482651
1,230,865
586,366
Whenever partial discharge is initiated, high frequency transient current pulses will appear and persist for nanoseconds to a microsecond, then disappear and reappear repeatedly as the voltage sinewave goes through the zero crossing. The PD happens near the peak voltage both positive and negative. PD pulses are easy to measure using the high frequency current transducer (HFCT) method. The current transducer is clamped around the case ground of the component being tested. The severity of the PD is measured by measuring the burst interval between the end of a burst and the beginning of the next burst. As the insulation breakdown worsens, the burst interval will shorten due to the breakdown happening at lower voltages. This burst interval will continue to shorten until a critical 2 millisecond point is reached. At this 2 ms point, the discharge is very close to the zero crossing and will fail with a full blown discharge and major failure. The HFCT method needs to be used because of the small magnitude and short duration of these PD events. The HFCT method is done while the component being tested stays energized and loaded. It is completely non-intrusive. Another method of measuring these currents is to put a small current-measuring resistor in series with the sample and then view the generated voltage on an oscilloscope via a matched coaxial cable.
https://en.wikipedia.org/wiki?curid=467804
586,066
772,361
One prominent example of common non-causal methodology is the erroneous assumption of correlative properties as causal properties. There is no inherent causality in phenomena that correlate. Regression models are designed to measure variance within data relative to a theoretical model: there is nothing to suggest that data that presents high levels of covariance have any meaningful relationship (absent a proposed causal mechanism with predictive properties or a random assignment of treatment). The use of flawed methodology has been claimed to be widespread, with common examples of such malpractice being the overuse of correlative models, especially the overuse of regression models and particularly linear regression models. The presupposition that two correlated phenomena are inherently related is a logical fallacy known as spurious correlation. Some social scientists claim that widespread use of methodology that attributes causality to spurious correlations have been detrimental to the integrity of the social sciences, although improvements stemming from better methodologies have been noted.
https://en.wikipedia.org/wiki?curid=37103476
771,947
1,203,331
There has been a boom in underwater environmental exploration; rather than simply creating a map, scientists are attempting to visualize the entire seafloor with maximum possible detail. Computers are put to good use here. With their help, researchers have managed to store and analyze large quantities of data. This led to the creation of the first digital map of the world ocean bed in 1970. Constantly developing technology allows computing to take place in the special equipment required for high-resolution orthoimagery. This means researchers may no longer need to use sound frequencies to conduct marine exploration.
https://en.wikipedia.org/wiki?curid=52233145
1,202,687
2,647
Compared to previous stealth designs like the F-117, the F-22 is less reliant on RAM, which are maintenance-intensive and susceptible to adverse weather conditions. Unlike the B-2, which requires climate-controlled hangars, the F-22 can undergo repairs on the flight line or in a normal hangar. The F-22 has a "Signature Assessment System" which delivers warnings when the radar signature is degraded and necessitates repair. While the F-22's exact RCS is classified, in 2009 Lockheed Martin released information indicating that from certain angles the airplane has an RCS of 0.0001 m or −40 dBsm – equivalent to the radar reflection of a "steel marble"; the aircraft can mount a Luneburg lens reflector to mask its RCS. Effectively maintaining the stealth features can decrease the F-22's mission capable rate to 62–70%.
https://en.wikipedia.org/wiki?curid=66299
2,647
176,119
Wavelet theory is applicable to several subjects. All wavelet transforms may be considered forms of time-frequency representation for continuous-time (analog) signals and so are related to harmonic analysis. Discrete wavelet transform (continuous in time) of a discrete-time (sampled) signal by using discrete-time filterbanks of dyadic (octave band) configuration is a wavelet approximation to that signal. The coefficients of such a filter bank are called the shift and scaling coefficients in wavelets nomenclature. These filterbanks may contain either finite impulse response (FIR) or infinite impulse response (IIR) filters. The wavelets forming a continuous wavelet transform (CWT) are subject to the uncertainty principle of Fourier analysis respective sampling theory: Given a signal with some event in it, one cannot assign simultaneously an exact time and frequency response scale to that event. The product of the uncertainties of time and frequency response scale has a lower bound. Thus, in the scaleogram of a continuous wavelet transform of this signal, such an event marks an entire region in the time-scale plane, instead of just one point. Also, discrete wavelet bases may be considered in the context of other forms of the uncertainty principle.
https://en.wikipedia.org/wiki?curid=50903
176,027
22,008
Smith discusses potential benefits of specialization by division of labour, including increased labour productivity and gains from trade, whether between town and country or across countries. His "theorem" that "the division of labor is limited by the extent of the market" has been described as the "core of a theory of the functions of firm and industry" and a "fundamental principle of economic organization." To Smith has also been ascribed "the most important substantive proposition in all of economics" and foundation of resource-allocation theory – that, under competition, resource owners (of labour, land, and capital) seek their most profitable uses, resulting in an equal rate of return for all uses in equilibrium (adjusted for apparent differences arising from such factors as training and unemployment).
https://en.wikipedia.org/wiki?curid=9223
21,999
1,076,837
Naturalistic observation, sometimes referred to as fieldwork, is a research methodology in numerous fields of science including ethology, anthropology, linguistics, the social sciences, and psychology, in which data are collected as they occur in nature, without any manipulation by the observer. Examples range from watching an animal's eating patterns in the forest to observing the behavior of students in a school setting. During naturalistic observation, researchers take great care using unobtrusive methods to avoid interfering with the behavior they are observing. Naturalistic observation contrasts with analog observation in an artificial setting that is designed to be an analog of the natural situation, constrained so as to eliminate or control for effects of any variables other than those of interest. There is similarity to observational studies in which the independent variable of interest cannot be experimentally controlled for ethical or logistical reasons.
https://en.wikipedia.org/wiki?curid=980435
1,076,282
2,023,065
In 2015, Schmidt was awarded a UF Research Opportunity Seed Fund for her project "Engineering Tissue Mimics to Investigate Congenital Heart Disease." The aim of her project was to engineer cardiac tissue mimics to investigate the role biophysical and biochemical cues play in the progression of congenital heart disease. Following this, her research earned her national recognition and Schmidt was named president-elect of the American Institute for Medical and Biological Engineering. She was also awarded the 2019 Clemson Award for Applied Research from the Society for Biomaterials and named a Fellow of the National Academy of Inventors (NAI). Her election to the NAI was due to her work in materials and cellular/tissue engineering leading to a "significant clinical impact on nerve repair and post-surgical wound care management."
https://en.wikipedia.org/wiki?curid=66225638
2,021,901
1,479,145
Culture-historical archaeology arose during a somewhat tumultuous time in European intellectual thought. The Industrial Revolution had spread across many nations, leading to the creation of large urban centres, most of which were filled with poverty stricken proletariat workers. This new urban working class had begun to develop a political voice through socialism, threatening the established political orders of many European states. Whilst some intellectuals had championed the Industrial Revolution as a progressive step forward, there were many who had seen it as a negative turn of events, disrupting the established fabric of society. This latter view was taken up by the Romanticist movement, which was largely made up of artists and writers, who popularised the idea of an idyllic ancient agrarian society.
https://en.wikipedia.org/wiki?curid=642813
1,478,312
981,669
In humans, ingestion of certain plant and animal (e.g., red meat, egg yolk) food containing lecithin, choline and L-carnitine provides certain gut microbiota with the substrate to synthesize TMA, which is then absorbed into the bloodstream. High levels of trimethylamine in the body are associated with the development of trimethylaminuria, or fish odor syndrome, caused by a genetic defect in the enzyme which degrades TMA; or by taking large doses of supplements containing choline or L-carnitine. TMA is metabolized by the liver to trimethylamine N-oxide (TMAO); TMAO is being investigated as a possible proatherogenic substance which may accelerate atherosclerosis in those eating foods with a high content of TMA precursors. TMA also causes the odor of some human infections, bad breath, and bacterial vaginosis.
https://en.wikipedia.org/wiki?curid=1620404
981,157
1,060,315
If hypofrontality is, in fact, caused by these inefficient synaptic connections, then the associated irregular dopaminergic activity in certain parts of the brain (the limbic striatum and mediodorsal thalamus) can be, in part, explained. Dopaminergic activity is the release (or lack thereof) of the neurotransmitter dopamine and the resulting cellular responses. The limbic striatum and mediodorsal thalamus (parts of the brain) have connections with a part of the prefrontal cortex called the corticolimbothalamic circuit. The corticolimbothalamic circuit has a high concentration of GABAergic interneurons, which are neurons that predominantly work with the inhibitory neurotransmitter GABA. As a result of the impaired synaptic connections, the GABAergic interneurons of the corticolimbothalamic circuit would adapt to release increasingly high amounts of GABA to send a signal of the correct strength. This recurrent activation of the GABAergic cells produces a strong inhibitory signal back to the limbic striatum and mediodorsal thalamus, which inhibits the dopaminergic activity in those parts of the brain. This resulting inhibition of dopaminergic activity produces reduced activity at the mRNA and protein level in cells. These cellular changes could call for less blood flow and glucose use specifically, or the less blood flow and glucose metabolism could simply be a result of the lowered cellular activity.
https://en.wikipedia.org/wiki?curid=40637173
1,059,764
1,013,458
Although forest plots can take several forms, they are commonly presented with two columns. The left-hand column lists the names of the studies (frequently randomized controlled trials or epidemiological studies), commonly in chronological order from the top downwards. The right-hand column is a plot of the measure of effect ("e.g." an odds ratio) for each of these studies (often represented by a square) incorporating confidence intervals represented by horizontal lines. The graph may be plotted on a natural logarithmic scale when using odds ratios or other ratio-based effect measures, so that the confidence intervals are symmetrical about the means from each study and to ensure undue emphasis is not given to odds ratios greater than 1 when compared to those less than 1. The area of each square is proportional to the study's weight in the meta-analysis. The overall meta-analysed measure of effect is often represented on the plot as a dashed vertical line. This meta-analysed measure of effect is commonly plotted as a diamond, the lateral points of which indicate confidence intervals for this estimate.
https://en.wikipedia.org/wiki?curid=11394359
1,012,937
1,364,480
"C. crescentus" derives its name from its crescent shape, which is caused by the protein crescentin. It is an interesting organism to study because it inhabits nutrient-poor aquatic environments. Their ability to thrive in low levels of nutrients is facilitated by its dimorphic developmental cycle. The swarmer cell has a flagellum that protrudes from a single pole and is unable to initiate DNA replication unless differentiated into a stalked cell. The differentiation process includes a morphological transition characterized by ejection of its flagellum and growth of a stalk at the same pole. Stalked cells can elongate and replicate their DNA while growing a flagellum at the opposite pole, giving rise to a pre-divisional cell. Although the precise function of stalks is still being investigated, it is likely that the stalks are involved in the uptake of nutrients in nutrient-limited conditions. Its use as a model originated with developmental biologist Lucy Shapiro.
https://en.wikipedia.org/wiki?curid=839361
1,363,724
270,121
In addition, the lack of defined methodology and regulations surrounding the consumption of dietary supplements hinders the application of bioavailability measures in comparison to drugs. In clinical trials with dietary supplements, bioavailability primarily focuses on statistical descriptions of mean or average AUC differences between treatment groups, while often failing to compare or discuss their standard deviations or inter-individual variation. This failure leaves open the question of whether or not an individual in a group is likely to experience the benefits described by the mean-difference comparisons. Further, even if this issue were discussed, it would be difficult to communicate meaning of these inter-subject variances to consumers and/or their physicians.
https://en.wikipedia.org/wiki?curid=769021
269,974
1,419,430
Following World War II, the Coast and Geodetic Survey resumed its peacetime scientific and surveying efforts. In 1945 it adapted the British Royal Air Forces Gee radio navigation system to hydrographic surveying, ushering in a new era of marine electronic navigation. In 1948 it established the Pacific Tsunami Warning Center in Honolulu Hawaii. The onset of the Cold War in the late 1940s led the Survey also to make a significant effort in support of defense requirements, such as conducting surveys for the Distant Early Warning Line and for rocket ranges, performing oceanographic work for the U.S. Navy, and monitoring nuclear tests.
https://en.wikipedia.org/wiki?curid=16021406
1,418,631
781,188
The massive skull of "Albertosaurus", which was perched on a short, S-shaped neck, was about long in the largest adults. Wide openings in the skull (fenestrae) reduced the weight of the head while also providing space for muscle attachment and sensory organs. Its long jaws contained, both sides combined, 58 or more banana-shaped teeth; larger tyrannosaurids possessed fewer teeth; "Gorgosaurus" had 62. Unlike most theropods, "Albertosaurus" and other tyrannosaurids were heterodont, with teeth of different forms depending on their position in the mouth. The premaxillary teeth at the tip of the upper jaw, four per side, were much smaller than the rest, more closely packed, and D-shaped in cross section. Like with "Tyrannosaurus", the maxillary (cheek) teeth of "Albertosaurus" were adapted in general form to resist lateral forces exerted by a struggling prey. The bite force of "Albertosaurus" was less formidable, however, with the maximum force, by the hind teeth, reaching 3,413 Newtons. Above the eyes were short bony crests that may have been brightly coloured in life and used in courtship to attract a mate.
https://en.wikipedia.org/wiki?curid=1367
780,770
305,113
In the first half of the 20th century, the Soviet Union and the communist parties of the Third International around the world mainly came to represent socialism in terms of the Soviet model of economic development and the creation of centrally planned economies directed by a state that owns all the means of production, although other trends condemned what they saw as the lack of democracy. In the United Kingdom, Herbert Morrison said that "socialism is what the Labour government does" whereas Aneurin Bevan argued that socialism requires that the "main streams of economic activity are brought under public direction", with an economic plan and workers' democracy. Some argued that capitalism had been abolished. Socialist governments established the mixed economy with partial nationalisations and social welfare.
https://en.wikipedia.org/wiki?curid=47246185
304,951
541,030
In 1957, André and Rouiller first coined the term "nuage". (French for "cloud"). Its amorphous and fibrous structure occurred in drawings as early as in 1933 (Risley). Today, the nuage is accepted to represent a characteristic, electrondense germ plasm organelle encapsulating the cytoplasmic face of the nuclear envelope of the cells destined to the germline fate. The same granular material is also known under various synonyms: "dense bodies, mitochondrial clouds, yolk nuclei, Balbiani bodies, perinuclear P granules in Caenorhabditis elegans, germinal granules in Xenopus laevis, chromatoid bodies in mice, and polar granules in Drosophila". Molecularly, the "nuage" is a tightly interwoven network of differentially localized RNA-binding proteins, which in turn localize specific mRNA species for differential storage, asymmetric segregation (as needed for asymmetric cell division), differential splicing and/or translational control. The germline granules appear to be ancestral and universally conserved in the germlines of all metazoan phyla.
https://en.wikipedia.org/wiki?curid=747128
540,750
1,062,019
In the field of cellular biology, single-cell analysis is the study of genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level. The concept of single-cell analysis originated in the 1970s. Before the discovery of heterogeneity, single-cell analysis mainly referred to the analysis or manipulation of an individual cell in a bulk population of cells at a particular condition using optical or electronic microscope. To date, due to the heterogeneity seen in both eukaryotic and prokaryotic cell populations, analyzing a single cell makes it possible to discover mechanisms not seen when studying a bulk population of cells. Technologies such as fluorescence-activated cell sorting (FACS) allow the precise isolation of selected single cells from complex samples, while high throughput single cell partitioning technologies, enable the simultaneous molecular analysis of hundreds or thousands of single unsorted cells; this is particularly useful for the analysis of transcriptome variation in genotypically identical cells, allowing the definition of otherwise undetectable cell subtypes. The development of new technologies is increasing our ability to analyze the genome and transcriptome of single cells, as well as to quantify their proteome and metabolome. Mass spectrometry techniques have become important analytical tools for proteomic and metabolomic analysis of single cells. Recent advances have enabled quantifying thousands of protein across hundreds of single cells, and thus make possible new types of analysis. In situ sequencing and fluorescence in situ hybridization (FISH) do not require that cells be isolated and are increasingly being used for analysis of tissues.
https://en.wikipedia.org/wiki?curid=38991948
1,061,465
841,554
In nonradiative relaxation, the energy is released as phonons, more commonly known as heat. Nonradiative relaxation occurs when the energy difference between the levels is very small, and these typically occur on a much faster time scale than radiative transitions. For many materials (for instance, semiconductors), electrons move quickly from a high energy level to a meta-stable level via small nonradiative transitions and then make the final move down to the bottom level via an optical or radiative transition. This final transition is the transition over the bandgap in semiconductors. Large nonradiative transitions do not occur frequently because the crystal structure generally cannot support large vibrations without destroying bonds (which generally doesn't happen for relaxation). Meta-stable states form a very important feature that is exploited in the construction of lasers. Specifically, since electrons decay slowly from them, they can be deliberately piled up in this state without too much loss and then stimulated emission can be used to boost an optical signal.
https://en.wikipedia.org/wiki?curid=28219
841,104
669,613
Metals or alloys like galinstan that are liquids at room temperature are often used by overclockers and enthusiasts as a thermal interface for computer hardware cooling, where their higher thermal conductivity compared to thermal pastes, and thermal epoxies can allow slightly higher clock speeds and CPU processing power achieved in demonstrations and competitive overclocking. Two examples are Thermal Grizzly Conductonaut and Coolaboratory Liquid Ultra, with thermal conductivities of 73 and 38.4 W/mK respectively. Unlike ordinary thermal compounds which are easy to apply and present a low risk of damaging hardware, galinstan is electrically conductive and causes liquid metal embrittlement in many metals including aluminum which is commonly used in heatsinks. Despite these challenges the users who are successful with their application do report good results. In August 2020, Sony Interactive Entertainment patented a galinstan-based thermal interface solution suitable for mass production, for use on the PlayStation 5.
https://en.wikipedia.org/wiki?curid=867089
669,263
133,790
Around the 9th century AD, the central Sudanic Empire of Kanem, with its capital at Njimi, was founded by the Kanuri-speaking nomads. Kanem arose by engaging in the trans-Saharan trade. It exchanged slaves captured by raiding the south for horses from North Africa, which in turn aided in the acquisition of slaves. By the late 11th century, the Islamic Sayfawa (Saifawa) dynasty was founded by Humai (Hummay) ibn Salamna. The Sayfawa dynasty ruled for 771 years, making it one of the longest-lasting dynasties in human history. In addition to trade, taxation of local farms around Kanem became a source of state income. Kanem reached its peak under "Mai" (king) Dunama Dibalemi ibn Salma (1210–1248). The empire reportedly was able to field 40,000 cavalry, and it extended from Fezzan in the north to the Sao state in the south. Islam became firmly entrenched in the empire. Pilgrimages to Mecca were common; Cairo had hostels set aside specifically for pilgrims from Kanem.
https://en.wikipedia.org/wiki?curid=14099
133,737
569,942
Commentators have primarily categorised "Calculating Infinity" as mathcore due to its frequent use of complex time signatures, atypical rhythms and unpredictable tempo changes. Many have claimed that The Dillinger Escape Plan "pioneered" or even "created" the genre with the release of their debut album. Others have described the album's style as metalcore, experimental metal, hardcore punk, and grindcore. Speaking to "The Independent", the band's guitarist Weinman suggested that the challenging nature of the album's material was intentional, explaining that ""Calculating Infinity" was us effectively ripping up the music theory book; if someone said 'don't harmonize with a second, it just sounds out of tune', then every single lead we did, we'd harmonize with a second. It sounded disgusting, but we did it". Natalie Zina Walschots of "Exclaim!" described the album's style as "even more avant-garde" than the band's first two extended plays, which she had noted featuring "complex and technical guitar work", "unpredictable shifts in tempo and tone" and "fractured song structures". "Decibel" writer Daniel Lake described the album as a combination of "gouts of noise, rhythmic chaos, jazzy runs and cinematic interludes".
https://en.wikipedia.org/wiki?curid=846067
569,652
725,497
Mayr also greatly influenced the American ornithologist Margaret Morse Nice. Mayr encouraged her to correspond with European ornithologists and helped her in her landmark study on song sparrows. Nice wrote to Joseph Grinnell in 1932, trying to get foreign literature reviewed in the "Condor": "Too many American ornithologists have despised the study of the living bird; the magazines and books that deal with the subject abound in careless statements, anthropomorphic interpretations, repetition of ancient errors, and sweeping conclusions from a pitiful array of facts.  ... in Europe the study of the living bird is taken seriously. We could learn a great deal from their writing." Mayr ensured that Nice could publish her two-volume "Studies in the Life History of the Song Sparrow". He found her a publisher, and her book was reviewed by Aldo Leopold, Joseph Grinnell, and Jean Delacour. Nice dedicated her book to "My Friend Ernst Mayr."
https://en.wikipedia.org/wiki?curid=9238
725,116
874,717
The delay in the rise or fall time of the circuit is in this case caused by the back-EMF from the inductor which, as the current flowing through it tries to change, prevents the current (and hence the voltage across the resistor) from rising or falling much faster than the time-constant of the circuit. Since all wires have some self-inductance and resistance, all circuits have a time constant. As a result, when the power supply is switched on, the current does not instantaneously reach its steady-state value, . The rise instead takes several time-constants to complete. If this were not the case, and the current were to reach steady-state immediately, extremely strong inductive electric fields would be generated by the sharp change in the magnetic field — this would lead to breakdown of the air in the circuit and electric arcing, probably damaging components (and users).
https://en.wikipedia.org/wiki?curid=1585348
874,255
598,780
Research by Klaus Wallmann et al. 2018 concluded that hydrate dissociation at Svalbard 8,000 years ago was due to isostatic rebound (continental uplift following deglaciation). As a result, the water depth got shallower with less hydrostatic pressure, without further warming. The study, also found that today's deposits at the site become unstable at a depth of ~ 400 meters, due to seasonal bottom water warming, and it remains unclear if this is due to natural variability or anthropogenic warming. Moreover, another paper published in 2017 found that only 0.07% of the methane released from the gas hydrate dissociation at Svalbard appears to reach the atmosphere, and usually only when the wind speeds were low. In 2020, a subsequent study confirmed that only a small fraction of methane from the Svalbard seeps reaches the atmosphere, and that the wind speed holds a greater influence on the rate of release than dissolved methane concentration on site.
https://en.wikipedia.org/wiki?curid=5069503
598,475
442,006
A grower utilizing a DWC system has to modify the environment as to provide the proper conditions for optimal growth. Although this is true for any protected-crop production system, such as greenhouses, indoor systems, or vertical farms; utilizing DWC comes with some specific responsibilities that the grower should heed. Most notably, the plants’ roots are suspended in a nutrient solution, opposed to a growing media. This requires special attention to specific parameters which are described below in more detail (oxygen, temperature, pH and nutrient concentration). As in other methods, soils and soilless media can assist in acting as a buffer for potentially harmful agents like disease or water quality concerns. Since the roots are directly cultured in the nutrient solution, the water quality is of the utmost concern.
https://en.wikipedia.org/wiki?curid=6781181
441,791
409,839
Heisenberg said in 1939 that the physicists at the (second) meeting said that "in principle atomic bombs could be made... it would take years... not before five." He said, "I didn't report it to the Führer until two weeks later and very casually because I did not want the Führer to get so interested that he would order great efforts immediately to make the atomic bomb. Speer felt it was better that the whole thing should be dropped and the Führer also reacted that way." He said they presented the matter in this way for their personal safety as the probability (of success) was nearly zero, but if many thousands (of) people developed nothing, that could have "extremely disagreeable consequences for us." So we turned the slogan around to "make use of warfare for physics" not "make use of physics for warfare." Erhard Milch asked how long America would take and was told 1944 though the group "between ourselves" thought it would take longer, three or four years.
https://en.wikipedia.org/wiki?curid=1397318
409,637
1,472,004
During EMT, the following major events occur: malignant epithelial cells lose their apical-basal polarity due to disruption in tight intercellular junctions and loss of cellular adhesion molecules (such as E-cadherin and integrins); the cellular actin cytoskeleton is changed and subjected to remodeling with the formation of stress fibers that are collected in certain cell parts near the cell membrane, where specific cellular protrusions begin subsequently to form; degradation of the underlying basal membrane of the epithelium occurs, which results in the fact that tumor cells lacking intercellular contacts become capable of invasive growth and penetration into the surrounding stromal matrix and begin active migration.
https://en.wikipedia.org/wiki?curid=58886026
1,471,175
758,646
The relief programs did offer indirect help. The Civil Works Administration (CWA) and Federal Emergency Relief Administration (FERA) focused on hiring unemployed people on relief, and putting them to work on public buildings, including public schools. It built or upgraded 40,000 schools, plus thousands of playgrounds and athletic fields. It gave jobs to 50,000 teachers to keep rural schools open and to teach adult education classes in the cities. It gave a temporary jobs to unemployed teachers in cities like Boston. Although the New Deal refused to give money to impoverished school districts, it did give money to impoverished high school and college students. The CWA used "work study" programs to fund students, both male and female.
https://en.wikipedia.org/wiki?curid=9083795
758,240
31,769
In practice, capacitors deviate from the ideal capacitor equation in several aspects. Some of these, such as leakage current and parasitic effects are linear, or can be analyzed as nearly linear, and can be accounted for by adding virtual components to the equivalent circuit of an ideal capacitor. The usual methods of network analysis can then be applied. In other cases, such as with breakdown voltage, the effect is non-linear and ordinary (normal, e.g., linear) network analysis cannot be used, the effect must be considered separately. Yet another group of artifacts may exist, including temperature dependence, that may be linear but invalidates the assumption in the analysis that capacitance is a constant. Finally, combined parasitic effects such as inherent inductance, resistance, or dielectric losses can exhibit non-uniform behavior at varying frequencies of operation.
https://en.wikipedia.org/wiki?curid=4932111
31,758
960,065
The haplochromine cichlid fishes in the Great Lakes of the East African Rift (particularly in Lake Tanganyika, Lake Malawi, and Lake Victoria) form the most speciose modern example of adaptive radiation. These lakes are believed to be home to about 2,000 different species of cichlid, spanning a wide range of ecological roles and morphological characteristics. Cichlids in these lakes fill nearly all of the roles typically filled by many fish families, including those of predators, scavengers, and herbivores, with varying dentitions and head shapes to match their dietary habits. In each case, the radiation events are only a few million years old, making the high level of speciation particularly remarkable. Several factors could be responsible for this diversity: the availability of a multitude of niches probably favored specialization, as few other fish taxa are present in the lakes (meaning that sympatric speciation was the most probable mechanism for initial specialization). Also, continual changes in the water level of the lakes during the Pleistocene (which often turned the largest lakes into several smaller ones) could have created the conditions for secondary allopatric speciation.
https://en.wikipedia.org/wiki?curid=1909
959,557
1,189,529
In 1952, when the release of the FCC's Sixth Report and Order announced the end of its freeze on new station license applications, among the issues the commission was slated to address was whether to approve the UPT-ABC merger. One FCC Commissioner saw the possibility of ABC, funded by UPT, becoming a viable and competitive third television network. On February 9, 1953, the FCC approved UPT's purchase of ABC in exchange for $25 million in shares. The merged company, renamed American Broadcasting-Paramount Theatres, Inc. and headquartered in the Paramount Building at 1501 Broadway in Manhattan, owned six AM and several FM radio stations, five television stations and 644 cinemas in 300 U.S. cities. To comply with FCC ownership restrictions in effect at the time that barred common ownership of two television stations in the same market, UPT sold its Chicago television station, WBKB-TV, to CBS (which subsequently changed the station's call letters to WBBM-TV) for $6 million, while it kept ABC's existing Chicago station, WENR-TV. The merged company acquired the WBKB call letters for channel 7, which would eventually become WLS-TV. Goldenson began to sell some of the older theaters to help finance the new television network.
https://en.wikipedia.org/wiki?curid=64765894
1,188,897
228,597
In the United States, most of these aircraft are privately owned and contracted to government agencies, and the National Guard and the U.S. Marines also maintain fleets of firefighting aircraft. On May 10, 2004, The U.S. Forest Service (USFS) and the Bureau of Land Management (BLM) announced that they were cancelling contracts with operators of 33 heavy airtankers. They cited liability concerns and an inability to safely manage the fleet after the wing failure and resulting crash of a C-130A Hercules in California and a PB4Y-2 in Colorado during the summer of 2002. Both aged aircraft broke up in flight due to catastrophic fatigue cracks at the wing roots. After subsequent third-party examination and extensive testing of all USFS contracted heavy airtankers, three companies were awarded contracts and now maintain a combined fleet of 23 aircraft.
https://en.wikipedia.org/wiki?curid=1143974
228,480
1,847,277
In 1985 the NTTTC (National Technical Teachers Training College) and Technical education unit of the Ministry of Education conducted a survey on the workforce. It was found that the ratio of chartered engineers to middle level engineers should be 1:3. However, according to the statistics it was 1:5:20, the ratio of chartered engineers, middle-level engineers and technicians respectively and it was not fulfilling necessary industry requirements. So the authorities realized the necessity of a new Engineering course to cater to the demand of Middle-Level Engineers for Sri Lankan and international industry as well. As a proposal UK based HNDE was introduced to Sri Lanka and which It was modified with Advanced Engineering Theoretical concept and Communication skills to suit modern-day industry and the course was extended for three and one-half years duration, including its six-month in-plant training period, with the approval of the Bolton University - England and was funded by the ADB.
https://en.wikipedia.org/wiki?curid=43835762
1,846,220
248,615
After the bones were prepared, photographed and studied, they were sent to New Jersey where work began on making the mount. This work consists of bending steel to support each bone safely and to display the entire skeleton articulated as it was in life. The real skull was not incorporated into the mount as subsequent study would be difficult with the head off the ground. Parts of the skull had been crushed and broken and thus appeared distorted. This also provides scientists with easier access to the skull as they continue to study it. The museum made a cast of the skull, and altered this cast to remove the distortions, thus approximating what the original undistorted skull may have looked like. The cast skull was also lighter, allowing it to be displayed on the mount without the use of a steel upright under the head. The original skull is exhibited in a case that can be opened to allow researchers access for study. Originally, the Field Museum had plans to incorporate SUE into their preexisting dinosaur exhibit on the second floor, but had little left in their budget to do so after purchasing it. Instead, the "T. rex" was put on display near the entrance on the first floor of the museum where it would remain for the next 18 years.
https://en.wikipedia.org/wiki?curid=10633984
248,487
851,076
Low-cost HMD devices are available for use with 3D games and entertainment applications. One of the first commercially available HMDs was the Forte VFX1 which was announced at Consumer Electronics Show (CES) in 1994. The VFX-1 had stereoscopic displays, 3-axis head-tracking, and stereo headphones. Another pioneer in this field was Sony, which released the Glasstron in 1997. It had as an optional accessory a positional sensor which permitted the user to view the surroundings, with the perspective moving as the head moved, providing a deep sense of immersion. One novel application of this technology was in the game "", which permitted users of the Sony Glasstron or Virtual I/O's iGlasses to adopt a new visual perspective from inside the cockpit of the craft, using their own eyes as visual and seeing the battlefield through their craft's own cockpit.
https://en.wikipedia.org/wiki?curid=1259296
850,623
1,874,565
Because of the mistaken belief in some quarters of the spread spectrum community that little could be gained from receivers more sophisticated than the single-user matched filter, multiuser detection did not start developing until the early 1980s. Verdu showed that the near-far problem suffered by CDMA was not inherent to this multiplexing technology and could be overcome by an optimum receiver that demodulates all users simultaneously. Verdu's receiver consisted of a bank of matched filters followed by a Viterbi algorithm. In the context of the capacity of the narrowband Gaussian two-user multiple-access channel, Cover showed the achievability of the capacity region by means of a successive cancellation receiver, which decodes one user treating the other as noise, re-encodes its signal and subtracts it from the received signal. The same near-far resistance of the optimum receiver can be achieved with the decorrelating receiver proposed in. Adaptive multiuser detectors that do not require prior knowledge of the interfering waveforms have also been proposed.
https://en.wikipedia.org/wiki?curid=9243688
1,873,488
962,310
Most glucometers today use an electrochemical method. Test strips contain a capillary that sucks up a reproducible amount of blood. The glucose in the blood reacts with an enzyme electrode containing glucose oxidase (or dehydrogenase). The enzyme is reoxidized with an excess of a mediator reagent, such as a ferricyanide ion, a ferrocene derivative or osmium bipyridyl complex. The mediator in turn is reoxidized by reaction at the electrode, which generates an electric current. In order for the mediator to operate over long timeframes, it needs to be stable in both oxidised and reduced states. This is to allow for continuous regeneration of the oxidised form of the mediator for shuttling of electrons from enzyme to active site. Osmium-based polypyridyl redox complexes and polymers are attractive candidates as mediators due to their stability in oxidised and reduced forms, tunable redox potential, ease of co-immobilisation and ability to operate at low potentials.
https://en.wikipedia.org/wiki?curid=1627125
961,801
1,057,902
The restrictions in the size of several flags fields, return codes and label types available in the basic DNS protocol prevented the support of some desirable features. Moreover, DNS messages carried by UDP were restricted to 512 bytes, not considering the Internet Protocol (IP) and transport layer headers. Resorting to a virtual circuit transport, using the Transmission Control Protocol (TCP), would greatly increase overhead. This presented a major obstacle to adding new features to DNS. In 1999, Paul Vixie proposed extending DNS to allow for new flags and response codes and to provide support for longer responses in a framework that is backwards compatible with previous implementations.
https://en.wikipedia.org/wiki?curid=5587160
1,057,353
587,678
The artists using the ornate style tended to favour large vessels, like volute "kraters", "amphorae", "loutrophoroi" and "hydriai". The larger surface area was used to depict up to 20 figures, often in several registers on the body of the vase. Additional colours, especially shades of red, yellow-gold and white are used copiously. Since the 2nd half of the 4th century, the necks and sides of the vases are decorated with rich vegetal or ornamental decorations. At the same time, perspective views, especially of buildings such as "Palace of Hades" ("naiskoi"), develop. Since 360 BC, such structures are often depicted in scenes connected with burial rites ("naiskos" vases). Important representatives of this style are the Ilioupersis Painter, the Darius Painter and the Baltimore Painter. Mythological scenes were especially popular: The assembly of the Gods, the amazonomachy, the Trojan War, Heracles and Bellerophon. Additionally, such vases frequently depict scenes from myths that are only rarely illustrated on vases. Some specimens represent the single source for the iconography of a particular myth. Another subject that is unknown from Attic vase painting are the theatre scenes. Especially farce scenes, e.g. from the so-called "phlyax" vases are quite common. Scenes of athletic activity or everyday life only occur in the early phase, they disappear entirely after 370 BC.
https://en.wikipedia.org/wiki?curid=1457406
587,376
4,102
The high elevation of the interior, the low temperatures, and the length of polar nights during the winter months all allow for better astronomical observations at Antarctica than anywhere else on Earth. The view of space from Earth is improved by a thinner atmosphere at higher elevations and a lack of water vapour in the atmosphere caused by freezing temperatures. Astrophysicists at the Amundsen–Scott South Pole Station study cosmic microwave background radiation and neutrinos from space. The largest neutrino detector in the world, the IceCube Neutrino Observatory, is at the Amundsen-Scott Station. It consists of around 5,500 digital optical modules, some of which reach a depth of , that are held in of ice.
https://en.wikipedia.org/wiki?curid=18959138
4,100
260,820
Go is a popular game in China, Japan and Korea, and the 2016 matches were watched by perhaps a hundred million people worldwide. Many top Go players characterized AlphaGo's unorthodox plays as seemingly-questionable moves that initially befuddled onlookers, but made sense in hindsight: "All but the very best Go players craft their style by imitating top players. AlphaGo seems to have totally original moves it creates itself." AlphaGo appeared to have unexpectedly become much stronger, even when compared with its October 2015 match where a computer had beaten a Go professional for the first time ever without the advantage of a handicap. The day after Lee's first defeat, Jeong Ahram, the lead Go correspondent for one of South Korea's biggest daily newspapers, said "Last night was very gloomy... Many people drank alcohol." The Korea Baduk Association, the organization that oversees Go professionals in South Korea, awarded AlphaGo an honorary 9-dan title for exhibiting creative skills and pushing forward the game's progress.
https://en.wikipedia.org/wiki?curid=49242352
260,684
555,062
Clathrate hydrate, which encaged CO as guest molecule is termed as CO hydrate. The term CO hydrates are more commonly used these days with its relevance in anthropogenic CO capture and sequestration. A nonstoichiometric compound, carbon dioxide hydrate, is composed of hydrogen-bonded water molecules arranged in ice-like frameworks that are occupied by molecules with appropriate sizes and regions. In structure I, the CO hydrate crystallizes as one of two cubic hydrates composed of 46 HO molecules (or DO) and eight CO molecules occupying both large cavities (tetrakaidecahedral) and small cavities (pentagonal dodecahedral). Researchers believed that oceans and permafrost have immense potential to capture anthropogenic CO in the form CO hydrates. The utilization of additives to shift the CO hydrate equilibrium curve in phase diagram towards higher temperature and lower pressures is still under scrutiny to make extensive large-scale storage of CO viable in shallower subsea depths.
https://en.wikipedia.org/wiki?curid=54140
554,773
640,484
The United States entered World War I on the side of the Entente Powers in April, 1917, without any tanks of its own. The following month, in the light of a report into British and French tank theories and operations, the American Expeditionary Forces' commander-in-chief, Gen. John Pershing, decided that both light and heavy tanks were essential for the conduct of the war and should be acquired as soon as possible. A joint Anglo-American programme was set up to develop a new type of heavy tank similar to those then in use by the British. It was, though, expected that sizeable quantities would not be available until April of the following year. Because of the wartime demands on French industry, the Inter-Allied Tank Commission decided that the quickest way to supply the American forces with sufficient armor was to manufacture the Renault FT light tank in the US.
https://en.wikipedia.org/wiki?curid=23084208
640,145
1,460,721
Insights into language storage in the brain have come from studying multilingual individuals afflicted with a form of aphasia. The symptoms and severity of aphasia in multilingual individuals depend on the number of languages the individual knows, what order they learned them, and thus have them stored in the brain, the age at which they learned them, how frequently each language is used, and how proficient the individual is in using those languages. Two primary theoretical approaches to studying and viewing multilingual aphasics exist—the localizationalist approach and the dynamic approach. The localizationalist approach views different languages as stored in different regions of the brain, explaining why multilingual aphasics may lose one language they know, but not the other(s). The dynamical theory (or shared representation) approach suggests that the language system is supervised by a dynamic equilibrium between the existing language capabilities and the constant alteration and adaptation to the communicative requirements of the environment. The dynamic approach views the representation and control aspects of the language system as compromised as a result of brain damage to the brain's language regions. The dynamic approach offers a satisfactory explanation for the various recovery times of each of the languages the aphasic has had impaired or lost because of the brain damage. Recovery of languages varies across aphasic patients. Some may recover all lost or impaired languages simultaneously. For some, one language is recovered before the others. In others, an involuntary mix of languages occurs in the recovery process; they intermix words from the various languages they know when speaking. Research affirms with the two approaches combined into the amalgamated hypothesis, it states that while languages do share some parts of the brain, they can also be allotted to some separate areas that are neutral.
https://en.wikipedia.org/wiki?curid=25181073
1,459,899
418,629
In his autobiography Arthur Rubinstein criticized Hofmann as someone who took interest in only the mechanics of music and not in its heart or spirituality, and commented that at the end of Hofmann's career "he was left with nothing after his technique left him". Claudio Arrau dismissed Hofmann (along with Paderewski) as someone who only happened to be very famous and said "I didn't know what to do with him". Sviatoslav Richter, after listening to a Hofmann RCA test pressing of the Scherzo from Beethoven's Sonata in E-flat, Op. 31, No. 3, considered the older pianist to be technically "stunning", but noted that Hofmann ignored the composer's "sforzando" markings; while György Sándor has called him the greatest of all 20th-century pianists in terms of music, interpretation, and technique. Hofmann's own student Shura Cherkassky compared Horowitz favorably with Hofmann as follows: "Hofmann was possibly the greater musical mind. But, I think, Horowitz was the greater pianist, the greater virtuoso—he somehow appealed to the whole world. Hofmann could not communicate on that level".
https://en.wikipedia.org/wiki?curid=440258
418,424
414,439
aHUS is not the only condition that causes systemic TMA, a fact that makes differential diagnosis essential. Historically, the clinical diagnosis of TMA-causing diseases was grouped into a broad category that (in addition to aHUS) included thrombotic thrombocytopenic purpura (TTP) and Shiga-toxin-producing Escherichia coli hemolytic uremic syndrome (STEC-HUS). However, it is now understood that although aHUS, STEC-HUS, and TTP have similar clinical presentations, they have distinct causes and specific tests can be conducted to differentiate these diseases. In addition, there are other conditions that can cause TMA as a secondary manifestation; these entities include systemic lupus erythematosus (SLE), malignant hypertension, progressive systemic sclerosis (PSS, also known as scleroderma), the pregnancy-associated HELLP (hemolysis, liver dysfunction, and low platelets) syndrome, and toxic drug reaction (e.g., to cocaine, cyclosporine, or tacrolimus). Nevertheless, aHUS should be suspected in patients presenting with systemic TMA, and appropriate diagnostic work-up should be undertaken.
https://en.wikipedia.org/wiki?curid=38187439
414,236
1,507,507
Geometric morphometrics can also be used to capture the slight shape variations found in postcranial bones of the human body such as "os coxae". Bierry and colleagues used 3D CT reconstructions of modern adult pelvic bones for 104 individuals to look at the shape of the obturator foramen. After a normalization technique to take out the factor of size, they outlined the obturator foramen with landmarks and semilandmarks to capture its shape. They chose the obturator foramen because it tends to be oval in males and triangular in females. The results show a classification accuracy of 88.5% for males and 80.8% for females using a Discriminant Fourier Analysis. Another study done by Gonzalez and colleagues used geometric morphometrics to capture the complete shape of the ilium and ischiopubic ramus. They placed landmarks and semilandmarks on 2D photographic images of 121 left pelvic bones from a collection of undocumented skeletons at the Museu Anthropológico de Coimbra in Portugal. Since the pelvic bones were of unknown origin, they used a K-means Cluster Analysis to determine a sex category before performing a Discriminant Function analysis. The results had a classification accuracy for the greater sciatic notch of 90.9% and the ischiopubic ramus at 93.4 to 90.1%
https://en.wikipedia.org/wiki?curid=45580833
1,506,661
631,728
Also under NASA's CCDev program, SpaceX was awarded $75 million for the development of their own version of a "pusher" LAS. Their Dragon 2 spacecraft was to use its SuperDraco engines during a launch abort scenario. Although often referred to as a "pusher" arrangement since it lacks a tower, the Dragon 2 LAS removes both the capsule and its trunk together from the launch vehicle. The system is designed to abort with the Super Draco engines at the top of the abort stack as occurs with a more traditional tractor LAS. The concept was first tested in a Pad Abort test conducted at SLC-40, Cape Canaveral Air Force Station, on May 6, 2015. SpaceX tested the system on January 19, 2020 during ascent of the Falcon 9 rocket in Kennedy Space Center Launch Complex 39, from where it has later launched crews to the International Space Station.
https://en.wikipedia.org/wiki?curid=1143181
631,390
33,018
After examining wrecked B-17s and B-24s, Luftwaffe officers discovered that on average it took about 20 hits with 20 mm shells fired from the rear to bring them down. Pilots of average ability hit the bombers with only about two percent of the rounds they fired, so to obtain 20 hits, the average pilot had to fire one thousand rounds at a bomber. Early versions of the Fw 190, one of the best German interceptor fighters, were equipped with two MG FF cannons, which carried only 500 rounds when belt-fed (normally using 60-round drum magazines in earlier installations), and later with the better Mauser MG 151/20 cannons, which had a longer effective range than the MG FF weapon. Later versions carried four or even six MG 151/20 cannon and twin 13 mm machine guns. The German fighters found that when attacking from the front, where fewer defensive guns were mounted (and where the pilot was exposed and not protected by armor as he was from the rear), it took only four or five hits to bring a bomber down.
https://en.wikipedia.org/wiki?curid=4997
33,006
576,827
MHA programs are thus intended to provide students with the essential knowledge required for senior managerial and planning work in the health services and systems sectors. The objectives of the program are to develop graduates who are: competent general and financial managers, competent planners, knowledgeable about public health and the structure, organization and financing of health care systems, knowledgeable about society, law and ethics, and competent in quantitative skills. "Health care is a labor intensive industry, no doubt about it and it’s not likely to change in the near future. Leadership of this human capital is uniquely challenging because of the diversity of both the workforce and the customer base and because of the life and death nature of our work." - Dr. RuthAnn Althaus
https://en.wikipedia.org/wiki?curid=4439485
576,531
1,496,867
In the spring of 1831 Drummond journeyed on foot by the Alleghany Mountains, reaching St. Louis in July, where he fell ill. In consequence of this delay he was unable to join the fur traders on their expedition to the north. He therefore was compelled to confine his explorations to New Orleans and thereabouts. Hence he made a botanical tour in Texas; at Velasco an attack of cholera prostrated him, but on recovering he continued his labours. Drummond collected along the Brazos, Colorado and Guadalupe Rivers, spending almost two years collecting plants and birds in Texas. His plant specimens from Texas were widely distributed in Europe and stimulated later botanical exploration. (Geiser, 1949) He embarked finally for Havana on 9 February 1835 and died at that port early in March. The plants sent home by Drummond were described by Sir William Hooker in his "Flora Boreali-Americana", his "Journal of Botany", and "Companion to the Botanical Magazine".
https://en.wikipedia.org/wiki?curid=32855572
1,496,024
41,795
WHP was first established in 2008 and immediately set about developing a new flywheel energy-recovery system for the Williams F1 Team after the introduction of Kinetic Energy Recovery Systems (KERS) into Formula One for the 2009 season. While other teams were pouring their efforts into electric battery systems, Williams F1 opted to go down the flywheel route because of a strong belief in the technology's wider applications. While it was never raced in Formula One due to technical changes, WHP has since seen its technology adapted for a range of applications. For example, the Audi R18 hybrid car that won the 2012 Le Mans 24 Hours used a WHP flywheel. WHP has also seen its flywheel technology introduced into a series of buses as part of a deal with the Go-Ahead Group, one of the UK's biggest transport operators. In April 2014, Williams Hybrid Power was sold to GKN.
https://en.wikipedia.org/wiki?curid=34104
41,780