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The first class of students at the Georgia School of Technology was small and homogeneous, and educational options were limited. Eighty-five students signed up on the first registration day, October 7, 1888, and the enrollment for the first year climbed to a total of 129 by January 7, 1889. The first student to register was William H. Glenn. All but one or two of the students were from Georgia. Tuition was free for Georgia residents and $150 () for out-of-state students. The only degree offered was a Bachelor of Science in mechanical engineering, and no elective courses were available. All students were required to follow exactly the same program, which was so rigorous that nearly two thirds of the first class failed to complete it. The first graduating class consisted of two students in 1890, Henry L. Smith and George G. Crawford, who decided their graduation order on the flip of a coin.
https://en.wikipedia.org/wiki?curid=8753550
1,773,036
181,206
OoC systems mimic and control the microenvironment of the cells by growing tissues in microfluidics. Combining tissue engineering, biomaterials fabrication, and cell biology, it offers the possibility of establishing a biomimetic model for studying human diseases in the laboratory. In recent years, 3D cell culture science has made significant progress, leading to the development of OoC. OoC is considered as a preclinical step that benefits pharmaceutical studies, drug development and disease modeling. OoC is an important technology that can bridge the gap between animal testing and clinical studies and also by the advances that the science has achieved could be a replace for in vivo studies for drug delivery and pathophysiological studies.
https://en.wikipedia.org/wiki?curid=1106830
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As a standard intended to satisfy needs of next-generation data networks (4G), WiMAX is distinguished by its dynamic burst algorithm modulation adaptive to the physical environment the RF signal travels through. Modulation is chosen to be more spectrally efficient (more bits per OFDM/SOFDMA symbol). That is, when the bursts have a high signal strength and a high carrier to noise plus interference ratio (CINR), they can be more easily decoded using digital signal processing (DSP). In contrast, operating in less favorable environments for RF communication, the system automatically steps down to a more robust mode (burst profile) which means fewer bits per OFDM/SOFDMA symbol; with the advantage that power per bit is higher and therefore simpler accurate signal processing can be performed.
https://en.wikipedia.org/wiki?curid=471844
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Another way to extend half-life do is to bind serum albumin to the peptide. Human serum albumin is the most abundant plasma protein with a molecular weight of 66.4 kDa, and it is involved in many essential bodily functions to maintain homeostasis. As a result, albumin binding would significantly increase the molecular weight of the peptide, restricting it from being filtered into the urine by the GBM. Serum albumin has an extraordinary long half-life of 2-4 weeks which is much longer than other plasma proteins, due to it binding to the neonatal Fc receptor (FcRn). Fc receptors are proteins found on the surface of certain cells that help to protect the functions of the immune system, by binding to the Fc region of antibodies, which attach to pathogens and destroy them. This mechanism of the neonatal FcRn involves albumin binding to the FcRn in an acidic pH environment to divert it from degradation in the lysosomal compartment of the cell, and redirecting it to the plasma membrane, where it is released back into the blood plasma due to neutral pH.
https://en.wikipedia.org/wiki?curid=67051842
1,656,835
896,911
Unable to find a passage, Drake turned south in the lone "Golden Hind" and in July 1579 sailed west across the Pacific. His travels took him to the Moluccas, Celebes, Java, and then round the Cape of Good Hope and finally the western tip of Africa. Drake arrived back in England in September 1580 with a rich cargo of spices and treasure and the distinction of being the first Englishman to circumnavigate the globe. Seven months later, Queen Elizabeth knighted him aboard the "Golden Hind", much to the annoyance of the king Philip II of Spain. As a result, the voyage was one of the precursors to the Anglo–Spanish War. Drake's intrusion into the Pacific, which Spain considered "Mare clausum", triggered an immediate Spanish colonization attempt of the Strait of Magellan aimed to block access to the Pacific.
https://en.wikipedia.org/wiki?curid=64312042
896,439
392,093
B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen through circulating lymph. At the SLO, B cell activation begins when the B cell binds to an antigen via its BCR. Although the events taking place immediately after activation have yet to be completely determined, it is believed that B cells are activated in accordance with the kinetic segregation model , initially determined in T lymphocytes. This model denotes that before antigen stimulation, receptors diffuse through the membrane coming into contact with Lck and CD45 in equal frequency, rendering a net equilibrium of phosphorylation and non-phosphorylation. It is only when the cell comes in contact with an antigen presenting cell that the larger CD45 is displaced due to the close distance between the two membranes. This allows for net phosphorylation of the BCR and the initiation of the signal transduction pathway. Of the three B cell subsets, FO B cells preferentially undergo T cell-dependent activation while MZ B cells and B1 B cells preferentially undergo T cell-independent activation.
https://en.wikipedia.org/wiki?curid=211941
391,898
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The West China Hospital of Stomatology has long been ranked as one of the nation's top hospitals. The hospital functions as the clinical treatment center for oral diseases and maxillofacial surgery in the Western-China area because of its abilities to provide full range of sophisticated diagnostic and therapeutic treatments. The hospital has a 54,540 square-meter new clinical building which hosts 350 dental units and 260 in-patient beds. The hospital annually treats about 400,000 outpatients (including emergency cases) and admits 4,000 inpatients among whom about 3,500 receive operations. In 2008, the magnitude 8 Wen Chuan earthquake occurred in Sichuan, timely first-aid and rescue service has been provided to people who were wounded in the disaster. Those operations of our hospital in the earthquake received nation's and provincial praising.
https://en.wikipedia.org/wiki?curid=29916018
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Investigation of the respiratory response to Acute intermittent hypoxia (AIH), repeated episodes of hypoxia, reveals connection to various breathing disorders, such as Rett syndrome and obstructive sleep apnea. AIH leads to persistent increases in respiratory frequency and amplitude of integrated motor neuronal bursts in vivo. These changes lasting for 90 minutes or longer are termed long-term facilitation (LTF). AIH causes homeostatic changes in multiple sites of the respiratory system; the pre-BötC is likely the site for the LTF, since intermittent hypoxia causes an increase in persistent frequency after ongoing hypoxia. The respiratory system is regulated by multiple forms of long-term synaptic plasticity. The role of synaptic inhibition has been proved widespread and critical within the expiratory Botzinger complex respiratory network, through cross-correlation and antidromic mapping techniques. The inhibitory connections discovered indicate their ability to connect different classes of neurons, their importance in regulating the interval of inspiration, and their ability to control driving potential of respiratory neurons. These characteristics show the interaction between the parafacial respiratory group and the pre-Bötzinger complex, which allows for active expiration to be produced by synaptic inhibition within the respiratory network. Synaptic inhibition is critical for allowing the pre-Bötzinger complex to communicate with other respiratory centers in order to generate respiratory activity.
https://en.wikipedia.org/wiki?curid=9045995
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According to a 2007 World Health Organization (WHO) report, 1.1 billion people lack access to an improved drinking water supply; 88% of the 4 billion annual cases of diarrheal disease are attributed to unsafe water and inadequate sanitation and hygiene, while 1.8 million people die from diarrhoeal disease each year. The WHO estimates that 94% of these diarrhoeal disease cases are preventable through modifications to the environment, including access to safe water. Simple techniques for treating water at home, such as chlorination, filters, and solar disinfection, and for storing it in safe containers could save a huge number of lives each year. Reducing deaths from waterborne diseases is a major public health goal in developing countries.
https://en.wikipedia.org/wiki?curid=214701
385,352
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During the following four weeks, while the ship was dry-docked, Bruce negotiated with the Argentine government over the future of the weather station. He was assisted by the British resident minister, the British Consul, and Dr W. G. Davis who was director of the Argentine Meteorological Office. When contacted by cable, the British Foreign Office registered no objection to this scheme. On 20 January 1904, Bruce confirmed an agreement whereby three scientific assistants of the Argentine government would travel back to Laurie Island to work for a year, under Robert Mossman, as the first stage of an annual arrangement. He then formally handed over the Omond House building, its furnishings and provisions, and all magnetic and meteorological instruments, to the Argentine government. The station, renamed Orcadas Base, has remained operational ever since, having been rebuilt and extended several times.
https://en.wikipedia.org/wiki?curid=4286037
1,351,205
697,382
Thermal spraying can provide thick coatings (approx. thickness range is 20 microns to several mm, depending on the process and feedstock), over a large area at high deposition rate as compared to other coating processes such as electroplating, physical and chemical vapor deposition. Coating materials available for thermal spraying include metals, alloys, ceramics, plastics and composites. They are fed in powder or wire form, heated to a molten or semimolten state and accelerated towards substrates in the form of micrometer-size particles. Combustion or electrical arc discharge is usually used as the source of energy for thermal spraying. Resulting coatings are made by the accumulation of numerous sprayed particles. The surface may not heat up significantly, allowing the coating of flammable substances.
https://en.wikipedia.org/wiki?curid=6434629
697,018
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In 2012, one year after the creation of the $35 million dollar CCAR fund, no money had been released to scientists. In February 2012, with no funding to continue station operations, CANDAC announced PEARL's impending closure. At the same time, the government announced final plans to build a new $204 million federal government Canadian High Arctic Research Station (CHARS) in Cambridge Bay, Nunavut. With an annual budget of $26.5 million, the government said this new facility would be "a world-class hub for science and technology in Canada's North." Located about 1200 km south of PEARL, this station is too far south to effectively measure ozone depletion or changes in the arctic atmosphere.
https://en.wikipedia.org/wiki?curid=62610276
1,858,406
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The nodal points were first described by Johann Listing in 1845 to evaluate the eye, where the image is formed in fluid. Over time it was found that if a line was drawn through the posterior apex of the crystalline lens at the visual angle of a distant object, then it would point to the image location on the retina, even for very large angles. This line passes approximately through the 2nd nodal point, but rather than being an actual paraxial ray, it identifies the image formed by ray bundles that pass through the center of the pupil. This can be used to find the magnification, or to scale retinal locations. This extends the use of the nodal point for the eye, but the imaging properties come from the cornea and retina being highly curved, rather than paraxial properties, and this is rarely clear in publications.
https://en.wikipedia.org/wiki?curid=4268332
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These students were selected from over 3,400 applicants for admission to the first year undergraduate engineering programmes of Aerospace, Chemical, Civil, Computer, Electrical, Engineering Physics, Energy, Mechanical, Metallurgical Engineering, and MSc Chemistry. One of the main objectives of establishing the institute was to develop facilities for studies in a variety of specialized engineering and technological sciences. The need for establishing adequate facilities for postgraduate studies and research was kept uppermost in mind in the founding years. While the institute was functioning provisionally at Worli, an effort was made to expedite the progress of the building project at its permanent location and Jawaharlal Nehru laid the foundation stone of the Institute at Powai on 10 March 1959.
https://en.wikipedia.org/wiki?curid=167354
385,202
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Phosphoglycolate phosphatase exhibits electrophoretically distinctive variant forms. Found in all human tissues, including red cells, lymphocytes, and cultured fibroblasts, the highest enzymatic activity was noted within skeletal and cardiac muscle. Research into the genetic polymorphism indicates that PGP is likely determined by three alleles at a single autosomal locus, which is expressed in all human tissues. Preliminary observations of fetal tissue suggest that the PGP locus is also fully expressed during intra-uterine life. Initial research has also shown appreciable genetic variation indicated by the detection of 6 phenotypes within a small European population.
https://en.wikipedia.org/wiki?curid=14457357
1,820,954
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Built as a one-third-size scale prototype, the DC-X was never designed to achieve orbital altitudes or velocity, but instead to demonstrate the concept of vertical take off and landing. The vertical take off and landing concept was popular in science fiction films from the 1950s ("Rocketship X-M", "Destination Moon", and others), but not seen in real world designs of space vehicles. It would take off vertically like standard rockets, but also land vertically with the nose up. This design used attitude control thrusters and retro rockets to control the descent, allowing the craft to begin atmospheric entry nose-first, but then roll around and touch down on landing struts at its base. The craft could be refueled where it landed, and take off again from exactly the same position — a trait that allowed unprecedented turnaround times.
https://en.wikipedia.org/wiki?curid=585987
719,055
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The use of weather charts in a modern sense began in the middle portion of the 19th century in order to devise a theory on storm systems. The development of a telegraph network by 1845 made it possible to gather weather information from multiple distant locations quickly enough to preserve its value for real-time applications. The Smithsonian Institution developed its network of observers over much of the central and eastern United States between the 1840s and 1860s. The U.S. Army Signal Corps inherited this network between 1870 and 1874 by an act of Congress, and expanded it to the west coast soon afterwards.
https://en.wikipedia.org/wiki?curid=73218
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Khatyrkite ( ) is a rare mineral which is mostly composed of copper and aluminium, but may contain up to about 15% of zinc or iron. Its chemical structure is described by an approximate formula or . It was discovered in 1985 in a placer in association with another rare mineral cupalite (). These two minerals have only been found at in the area of the Iomrautvaam, a tributary of the Khatyrka river, in the Koryak Mountains, in Anadyrsky District (former Beringovsky District), Chukotka, Russia. Analysis of one of the samples containing khatyrkite showed that the small rock was from a meteorite. A geological expedition has identified the exact place of the original discovery and found more specimens of the Khatyrka meteorite. The mineral's name derives from the Khatyrka () zone where it was discovered. Its type specimen (defining sample) is preserved in the Mining Museum in Saint Petersburg, and parts of it can be found in other museums, such as Museo di Storia Naturale di Firenze.
https://en.wikipedia.org/wiki?curid=23910190
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Kohn anomalies arise together with Friedel oscillations when one considers the Lindhard theory instead of the Thomas–Fermi approximation in order to find an expression for the dielectric function of a homogeneous electron gas. The expression for the real part formula_2 of the reciprocal space dielectric function obtained following the Lindhard theory includes a logarithmic term that is singular at formula_3, where formula_4 is the Fermi wavevector. Although this singularity is quite small in reciprocal space, if one takes the Fourier transform and passes into real space, the Gibbs phenomenon causes a strong oscillation of formula_5 in the proximity of the singularity mentioned above. In the context of phonon dispersion relations, these oscillations appear as a vertical tangent in the plot of formula_6, called the Kohn anomalies.
https://en.wikipedia.org/wiki?curid=9585894
1,740,646
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The application of hydraulics to cam-based automation resulted in tracing machines that used a stylus to trace a template, such as the enormous Pratt & Whitney "Keller Machine", which could copy templates several feet across. Another approach was "record and playback", pioneered at General Motors (GM) in the 1950s, which used a storage system to record the movements of a human machinist, and then play them back on demand. Analogous systems are common even today, notably the "teaching lathe" which gives new machinists a hands-on feel for the process. None of these were numerically programmable, however, and required an experienced machinist at some point in the process, because the "programming" was physical rather than numerical.
https://en.wikipedia.org/wiki?curid=39469106
1,038,111
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From 1814 to 1819, Irish chemist William Higgins claimed that Dalton had plagiarised his ideas, but Higgins' theory did not address relative atomic mass. Recent evidence suggests that Dalton's development of thought may have been influenced by the ideas of another Irish chemist Bryan Higgins, who was William's uncle. Bryan believed that an atom was a heavy central particle surrounded by an atmosphere of caloric, the supposed substance of heat at the time. The size of the atom was determined by the diameter of the caloric atmosphere. Based on the evidence, Dalton was aware of Bryan's theory and adopted very similar ideas and language, but he never acknowledged Bryan's anticipation of his caloric model. However, the essential novelty of Dalton's atomic theory is that he provided a method of calculating relative atomic weights for the chemical elements, which provides the means for the assignment of molecular formulas for all chemical substances. Neither Bryan nor William Higgins did this, and Dalton's priority for that crucial innovation is uncontested.
https://en.wikipedia.org/wiki?curid=44112
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An alternative is to reduce the plasma injection velocity and density to result in formula_355 to achieve a plasma in equilibrium with the inflated magnetic field and therefore induce an equatorial diamagnetic current in the same direction as the coil current as shown in the figure, thereby increasing the magnetic moment of the MPS field source and consequently increasing thrust. In 2013 Funaki and others published simulation and theoretical results regarding how characteristics of the injected plasma affected thrust gain through creation of an equatorial ring current. They defined thrust gain for MPS as formula_356: the ratio of the force generated by low beta plasma injection formula_357 divided by that of a pure magnetic sail formula_358 from equation with formula_359 and formula_360 for formula_361 or from equation for formula_362. They reported formula_363 of approximately 40 for magnetospheres less than the MHD applicability test and 3.77 for a larger magnetosphere where MHD applicability occurred, larger than values reported in 2012 of 20 and 3.3, respectively. Simulations revealed that optimum thrust gain occurred for formula_355 and formula_365.
https://en.wikipedia.org/wiki?curid=37845
1,042,414
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By 1917, a thin white outline was usually added to the roundel, to make the blue of the outer circle easier to distinguish from the dark PC.10 and PC.12 protective doping. On squadrons operating at night there was not the same need to make the marking more conspicuous, in fact it became customary to overpaint the white ring of the roundel itself – either in the camouflage finish of the aircraft as a whole, or in red. By the end of the war this had become standardised as the so-called "night roundel" of blue and red, that continued to be used on the dark NIVO green camouflage of post-war night bombers. Most RAF aircraft now had a silver finish (bare metal or aluminium doping) so that the national markings were conspicuous enough without outlining. During the late 1930s, RAF and Fleet Air Arm (FAA) aircraft were once again camouflaged, and a new outline was introduced, this time trainer yellow, and the same width as the blue and white rings.
https://en.wikipedia.org/wiki?curid=6968060
859,014
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So far, China has created the Gaoligongshan and Tongbiguan National Nature Reserves that currently house small populations of the eastern hoolock gibbon, and the Mahamyaing Sanctuary in Myanmar also acts as a gibbon shelter, as does the Hukaung Valley Tiger Reserve, which has noted that some gibbons live within its boundaries. Within Arunachal Pradesh, the Forest Department has been working with the Wildlife Trust of India to transfer gibbon groups to the Mehao Wildlife Sanctuary, and the Biological Park of Itanagar has created a program to captive-breed this species and release them into the wild with the collaboration of the Central Zoo Authority. India has also made killing or capturing the eastern hoolock gibbon illegal, but has few resources to be able to enforce the laws, thus is more focused on protecting larger mammals.
https://en.wikipedia.org/wiki?curid=16225919
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Lin was born in Tonghua, Jilin, in July 1954. After the resumption of National College Entrance Examination, he matriculated at Changchun Institute of Geology (now Jilin University), where he received his bachelor's degree in 1982 and his master's degree in 1987 both in exploration geophysics. After graduation, he taught at the university, where he was promoted to associate professor in 1991 and to full professor in 1992. He was a visiting scholar and then visiting professor at the University of Leicester from October 1989 to November 1991. He was also a senior visiting scholar at the University of Arizona from November 1996 to May 1997. In April 2000 he appointed dean of the School of Information Science and Technology. After this office was terminated in May 2001, he became executive vice-dean of the College of Electronic Science and Engineering, serving until December 2004. He has been dean of the College of Instrumentation and Electrical Engineering since April 2005.
https://en.wikipedia.org/wiki?curid=63002257
2,183,021
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As a C. L. E. Moore instructor, Rudin taught the real analysis course at MIT in the 1951–1952 academic year. After he commented to W. T. Martin, who served as a consulting editor for McGraw Hill, that there were no textbooks covering the course material in a satisfactory manner, Martin suggested Rudin write one himself. After completing an outline and a sample chapter, he received a contract from McGraw Hill. He completed the manuscript in the spring of 1952, and it was published the year after. Rudin noted that in writing his textbook, his purpose was "to present a beautiful area of [m]athematics in a well-organized readable way, concisely, efficiently, with complete and correct proofs. It was an [a]esthetic pleasure to work on it."
https://en.wikipedia.org/wiki?curid=70241079
1,371,883
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HMS "Rose" was built in Hull, England in 1757, as a 20 gun sixth-rate post ship for the British Royal Navy. In the Seven Years' War, "Rose" was in service in the Channel and in the Caribbean. She was briefly considered for service as Captain James Cook's vessel on his first exploration of the Pacific, but was rejected as unable to stow the quantity of provisions required for the planned circumnavigation of the globe. Instead she was sent to the North American station, en route to which she encountered Cook's ultimate choice of vessel, on 12 September 1768 when the two ships anchored alongside each other at Funchal in the Madeira Islands.
https://en.wikipedia.org/wiki?curid=2652856
1,174,126
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Lazarsfeld and Merton first called attention to the principles of homophily and its opposite, heterophily. Using their definition, Rogers defines homophily as "the degree to which pairs of individuals who interact are similar in certain attributes, such as beliefs, education, social status, and the like". When given the choice, individuals usually choose to interact with someone similar to themselves. Homophilous individuals engage in more effective communication because their similarities lead to greater knowledge gain as well as attitude or behavior change. As a result, homophilous people tend to promote diffusion among each other. However, diffusion requires a certain degree of heterophily to introduce new ideas into a relationship; if two individuals are identical, no diffusion occurs because there is no new information to exchange. Therefore, an ideal situation would involve potential adopters who are homophilous in every way, except in knowledge of the innovation.
https://en.wikipedia.org/wiki?curid=1123434
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At the same time, India was trying to launch its national space program under the leadership of Vikram Sarabhai. India was interested in the role of satellites for the purpose of communication and asked UNESCO to undertake a feasibility study for a project in that field. Between 18 November 1967 and 8 December 1967, UNESCO sent an expert mission to India to prepare a report on a pilot project in the use of satellite communication. The expert panel concluded that the such a project would be feasible. Following the report, a study team of three engineers from India visited USA and France in June 1967, and came to the conclusion that India could meet the technical requirements for the project. Following this, the Indian government set up the National Satellite Communications Group SATCOM in 1968 to look into the possible uses of a synchronous communications satellite for India. This group consisted of representatives from various cabinet ministries, ISRO and All India Radio (AIR) And Doordarshan. The group recommended that India should use the ATS-6 satellite– a second generation satellite developed by NASA– for an experiment in educational television.
https://en.wikipedia.org/wiki?curid=8248653
1,101,850
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It stores 1,200 China-based academic publications which in aggregate have 2million entries. According to Jingfeng Xia, CSCD is "the earliest database in China" and "is widely recognized as one of the best databases for Chinese scientific literature". In a 2005 article in the "Journal of the Association for Information Science and Technology", Loet Leydesdorff and Jin Bihui found that CSCD is "integrated by a maze of university-based journals". They continued, "In summary, one could say that the Chinese Science Citation Database exhibits the characteristics of transdisciplinary integration in the production of scientific knowledge more than its Western counterparts. In addition to intellectual organization a layer of institutional integration provides a focus on the priorities of the economy and the state that is absent in the international database."
https://en.wikipedia.org/wiki?curid=47180611
1,956,234
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"Tremella fuciformis" has been cultivated in China since at least the nineteenth century. Initially, suitable wooden poles were prepared and then treated in various ways in the hope that they would be colonized by the fungus. This haphazard method of cultivation was improved when poles were inoculated with spores or mycelium. Modern production only began, however, with the realization that both the "Tremella" and its host species needed to be inoculated into the substrate to ensure success. The "dual culture" method, now used commercially, employs a sawdust mix inoculated with both fungal species and kept under optimal conditions. The most popular species to pair with "T. fuciformis" is its preferred host, "Annulohypoxylon archeri". Estimated production in China in 1997 was 130,000 tonnes. "Tremella fuciformis" is also cultivated in other East Asian countries, with some limited cultivation elsewhere.
https://en.wikipedia.org/wiki?curid=1140453
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Gadavist was approved in the United States in 2011 after presenting findings from 43 clinical studies that had primarily taken place in Asia and the European Union, in addition to one phase 2 and two phase 3 clinical trials conducted in the United States. The multi-center, randomized, double-blind phase 3 clinical trials (one completed without the active comparator arm) enrolled 402 patients referred for a contrast-enhanced MRI of the CNS, both male and female, over the age of 18. Each patient received a single dose of gadobutrol (0.1 mmol/kg body weight) via intravenous injection, followed by a single dose of gadoteridol (ProHance) at the approved dose (0.1 mmol/kg body weight) via intravenous injection, or vice versa. The study evaluated safety and efficacy of gadobutrol. From these phase 3 clinical trials, the following conclusions were made:
https://en.wikipedia.org/wiki?curid=15535663
1,294,354
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Prismane is a colourless liquid at room temperature. The deviation of the carbon-carbon bond angle from 109° to 60° in a triangle leads to a high ring strain, reminiscent of that of cyclopropane but greater. The compound is explosive, which is unusual for a hydrocarbon. Due to this ring strain, the bonds have a low bond energy and break at a low activation energy, which makes synthesis of the molecule difficult; Woodward and Hoffmann noted that prismane's thermal rearrangement to benzene is symmetry-forbidden, comparing it to "an angry tiger unable to break out of a paper cage." On account of its strain energy and the aromatic stabilization of benzene, the molecule is estimated to be 90 kcal/mole less stable than benzene, but the activation of this highly exothermic transformation is a surprisingly high 33 kcal/mol, making it persistent at room temperature.
https://en.wikipedia.org/wiki?curid=2563306
1,135,242
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The "Medical and Surgical History of the War of the Rebellion" was first suggested by Surgeon General Hammond in a circular to medical officers inviting cooperation in the collection of material. In 1865 there was issued by the Surgeon General a report upon the extent and nature of the material available for its preparation. Four of the six monumental volumes were completed under General Barnes' administration and the other two were far advanced at the time of his retirement. His regime was further notable for the interest he took in the development of the Army Medical Library. During his term of office, the library, under the supervision of Major John S. Billings, was expanded from a small collection of text-books to first rank among medical libraries of the country. In 1871, General Barnes co-founded the Philosophical Society of Washington, a scientific organization, which met for some time in the annex of the Surgeon General's office before moving to Ford's Theater.
https://en.wikipedia.org/wiki?curid=12596950
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When it was first developed by Empress Dowager Cixi, the Beiyang Fleet was said to be the strongest navy in East Asia. Before her adopted son, Emperor Guangxu, took over the throne in 1889, Cixi wrote out explicit orders that the navy should continue to develop and expand gradually. However, after Cixi went into retirement, all naval and military development came to a drastic halt. Japan's victories over China has often been falsely rumored to be the fault of Cixi. Many believed that Cixi was the cause of the navy's defeat by embezzling funds from the navy in order to build the Summer Palace in Beijing. However, extensive research by Chinese historians revealed that Cixi was not the cause of the Chinese navy's decline. In actuality, China's defeat was caused by Emperor Guangxu's lack of interest in developing and maintaining the military. His close adviser, Grand Tutor Weng Tonghe, advised Guangxu to cut all funding to the navy and army, because he did not see Japan as a true threat, and there were several natural disasters during the early 1890s which the emperor thought to be more pressing to expend funds on.
https://en.wikipedia.org/wiki?curid=407942
832,713
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In November 2017, scientists led by Davide Massari of the Kapteyn Astronomical Institute, University of Groningen, Netherlands released a paper describing the characterization of proper motion (3D) within the Sculptor dwarf galaxy, and of that galaxy's trajectory through space and with respect to the Milky Way, using data from "Gaia" and the Hubble Space Telescope. Massari said, "With the precision achieved we can measure the yearly motion of a star on the sky which corresponds to less than the size of a pinhead on the Moon as seen from Earth." The data showed that Sculptor orbits the Milky Way in a highly elliptical orbit; it is currently near its closest approach at a distance of about , but the orbit can take it out to around distant.
https://en.wikipedia.org/wiki?curid=801330
936,190
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There is something of a gap between Prefaces I and II. Apollonius has sent his son, also Apollonius, to deliver II. He speaks with more confidence, suggesting that Eudemus use the book in special study groups, which implies that Eudemus was a senior figure, if not the headmaster, in the research center. Research in such institutions, which followed the model of the Lycaeum of Aristotle at Athens, due to the residency of Alexander the Great and his companions in its northern branch, was part of the educational effort, to which the library and museum were adjunct. There was only one such school in the state. Owned by the king, it was under royal patronage, which was typically jealous, enthusiastic, and participatory. The kings bought, begged, borrowed and stole the precious books whenever and wherever they could. Books were of the highest value, affordable only to wealthy patrons. Collecting them was a royal obligation. Pergamon was known for its parchment industry, whence “parchment” is derived from “Pergamon.”
https://en.wikipedia.org/wiki?curid=257242
810,465
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Birkhoff, a friend of John von Neumann, took a close interest in the rise of the electronic computer. Birkhoff supervised the Ph.D. thesis of David M. Young on the numerical solution of the partial differential equation of Poisson, in which Young proposed the successive over-relaxation (SOR) method. Birkhoff then worked with Richard S. Varga, a former student, who was employed at Bettis Atomic Power Laboratory of the Westinghouse Electronic Corporation in Pittsburgh and was helping to design nuclear reactors. Extending the results of Young, the Birkhoff–Varga collaboration led to many publications on positive operators and iterative methods for "p"-cyclic matrices.
https://en.wikipedia.org/wiki?curid=1180916
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Modern competition gliders carry jettisonable water ballast (in the wings and sometimes in the vertical stabilizer). The extra weight provided by the water ballast is advantageous if the lift is likely to be strong, and may also be used to adjust the glider's center of mass. Moving the center of mass toward the rear by carrying water in the vertical stabilizer reduces the required down-force from the horizontal stabilizer and the resultant drag from that down-force. Although heavier gliders have a slight disadvantage when climbing in rising air, they achieve a higher speed at any given glide angle. This is an advantage in strong conditions when the gliders spend only a small amount of time climbing in thermals. The pilot can jettison the water ballast before it becomes a disadvantage in weaker thermal conditions. Another use of water ballast is to dampen air turbulence such as might be encountered during ridge soaring. To avoid undue stress on the airframe, gliders must jettison any water ballast before landing.
https://en.wikipedia.org/wiki?curid=25856119
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Switching and all-by-sea routing commonly increases the distance and thus the round trip latency by more than 50%. For example, the round trip delay (RTD) or latency of the fastest transatlantic connections is under 60 ms, close to the theoretical optimum for an all-sea route. While in theory, a great circle route (GCP) between London and New York City is only , this requires several land masses (Ireland, Newfoundland, Prince Edward Island and the isthmus connecting New Brunswick to Nova Scotia) to be traversed, as well as the extremely tidal Bay of Fundy and a land route along Massachusetts' north shore from Gloucester to Boston and through fairly built up areas to Manhattan itself. In theory, using this partial land route could result in round trip times below 40 ms (which is the speed of light minimum time), and not counting switching. Along routes with less land in the way, round trip times can approach speed of light minimums in the long term.
https://en.wikipedia.org/wiki?curid=45206
131,103
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He was born to missionary parents (Jesse and Evelyn "Granny" Brand) and grew up in the Kolli Hills of Tamil Nadu, India, until he was sent to the United Kingdom in 1923 for education. In his books he gives vivid descriptions of his time as a boy in India with regular bouts of dysentery and malaria in the area known as "Kolli Malai". His father died in 1929 of blackwater fever, when Brand was 15. Brand trained in medicine at University College Hospital during the Second World War, and later gained his surgical qualifications whilst working as a casualty surgeon in the London Blitz. He met his wife, Margaret, in medical school. She too was a surgeon. He died on 8 July 2003 at Swedish Hospital in Seattle, Washington.
https://en.wikipedia.org/wiki?curid=1545657
1,281,472
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The USPHS recruiting campaign was aimed at reaching the maximum number of potential applicants in the shortest period of time. The primary target was the high-school graduate but college women were also recruited. The selling point was free education in a proud profession while providing an essential service to the country. Appeals to join the CNC reached more than 7,000,000 newspaper and magazine readers, and millions of radio listeners and movie patrons around the country. Pleas were made in speeches, through billboards, and in leaflets. U.S. corporations donated $13,000,000 worth of advertising space and technical services to the program in one year. Nearly every type of media source advertised for the CNC.
https://en.wikipedia.org/wiki?curid=3685821
1,702,639
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However, MTag's best-studied functions center on its interaction with host cell proteins to activate cellular signaling pathways. Like STag, MTag can bind protein phosphatase 2A (PP2A) through the same physical mechanism, interacting with the A subunit in a way that occludes binding of PP2A B subunits and thus inactivates the enzyme. This interaction is required for the formation of other MTag-host cell protein complexes; however, PP2A catalytic activity is not required. For example, MTag binds and activates Src-family protein tyrosine kinases in a PP2A-dependent manner, and in turn is phosphorylated by Src on tyrosine residues in the MTag C-terminus. Preference for members of the Src family varies, with mouse and hamster polyomavirus MTags having different distributions. Once phosphorylated, MTag interacts with and activates downstream signaling pathways through Shc, 14-3-3 proteins, phosphoinositide 3-kinase, and phospholipase Cγ1. The signaling functions of the phosphorylated MTag have been described as behaving like a mimic of a constitutively active receptor tyrosine kinase.
https://en.wikipedia.org/wiki?curid=53277567
1,859,822
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ALAD enzymatic activity is inhibited by lead, beginning at blood lead levels that were once considered to be safe (<10 μg/dL) and continuing to correlate negatively across the range from 5 to 95 μg/dL. Inhibition of ALAD by lead leads to anemia primarily because it both inhibits heme synthesis and shortens the lifespan of circulating red blood cells, but also by stimulating the excessive production of the hormone erythropoietin, leading to inadequate maturation of red cells from their progenitors. A defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternatively spliced transcript variants encoding different isoforms have been identified.
https://en.wikipedia.org/wiki?curid=14167645
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1,638,698
The 1000 genomes project was able to successfully produce the DNA sequence of the human genome. They provided much sequencing data from many populations to analyze as well as a reference human genome for comparison and future studies. One study took advantage of this resource to question the structural variation differences between genomes from whole genome sequence data. It was known that human diseases are affected by duplications and deletions and that copy number analysis is common but multiallelic copy number variants (mCNVs) were not as well studied. The researchers got their data from the 1000 genomes project and analyzed 849 different genomes from a variety of populations that were sequenced in order to find large mCNVs. From their analysis, they found that mCNVs create most genetic variation in gene dosage compared to other structural variants and that the gene expression variation is created by the dosage diversity of genes created by mCNVs. The study underlined the great significance that structural variants, especially mCNVs, have on gene dosage which leads to variable gene expressions and human phenotypic diversity in the population.
https://en.wikipedia.org/wiki?curid=50518079
1,637,773
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Understanding how these troughs formed in the young Raditladi basin could provide an important indicator of processes that acted relatively recently in Mercury's geologic history. There are two main theories of graben formation. The first is that they represent a surface manifestation of ring dikes or cone sheets. Both types of structures form when magma from a deep reservoir intrudes into the overlying rocks along conical or cylindrical fractures. The second hypothesis holds that the graben formed as a result of the floor uplift caused by the weight of the smooths plains outside the crater. Such plains are indeed present to the north and east of Raditladi, although their thickness and age are not known.
https://en.wikipedia.org/wiki?curid=23212267
2,091,789
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The MGI resource was first published online in 1994 and is a collection of data, tools, and analyses created and tailored for use in the laboratory mouse, a widely used model organism. It is "the authoritative source of official names for mouse genes, alleles, and strains", which follow the guidelines established by the International Committee on Standardized Genetic Nomenclature for Mice. The history and focus of Jackson Laboratory research and production facilities generates tremendous knowledge and depth which researchers can mine to advance their research. A dedicated community of mouse researchers, worldwide enhances and contributes to the knowledge as well. This is an indispensable tool for any researcher using the mouse as a model organism for their research, and for researchers interested in genes that share homology with the mouse genes. Various mouse research support resources including animal collections and free colony management software are also available at the MGI site.
https://en.wikipedia.org/wiki?curid=10432703
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Another method tested in a study to produce sodium polyacrylate as an alternative to current methods began with Butyl acrylate-acrylic acid copolymer and poly (butyl acrylate). They were synthesized via suspension polymerization by using butyl acrylate as the main monomer and acrylic acid as a secondary monomer. Suspension polymerization uses physical and mechanical movement and agitation in order to mix monomers to form polymers. This process requires dispersing medium, monomers, stabilizing agents, and initiators. Next, the polymers were swollen in ethanol and hydrolyzed in an aqueous solution of sodium hydroxide. Finally, water-soluble sodium polyacrylates were obtained by washing and drying the hydrolyzed resultant. This is a different method compared to the manufacturing processes that have been previously utilized, but could be a potential method to specifically manufacture sodium polyacrylate. Overall, the various production methods of sodium polyacrylate will influence its swelling capability, absorbency, and other mechanical properties. It is also important to consider cost and feasibility when manufacturing polymers like sodium polyacrylate.
https://en.wikipedia.org/wiki?curid=2915728
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Following the Operation Crossbow bombing, initial plans for launching from the massive underground Watten, Wizernes and Sottevast bunkers or from fixed pads such as near the Château du Molay were dropped in favour of mobile launching. Eight main storage dumps were planned and four had been completed by July 1944 (the one at Mery-sur-Oise was begun in August 1943 and completed by February 1944). The missile could be launched practically anywhere, roads running through forests being a particular favourite. The system was so mobile and small that only one was ever caught in action by Allied aircraft, during the Operation Bodenplatte attack on 1 January 1945 near Lochem by a USAAF 4th Fighter Group aircraft, although Raymond Baxter described flying over a site during a launch and his wingman firing at the missile without hitting it.
https://en.wikipedia.org/wiki?curid=32786
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In radio-frequency applications up to a few gigahertz, the wave propagates primarily in the transverse electric magnetic (TEM) mode, which means that the electric and magnetic fields are both perpendicular to the direction of propagation. However, above a certain cutoff frequency, transverse electric (TE) or transverse magnetic (TM) modes can also propagate, as they do in a hollow waveguide. It is usually undesirable to transmit signals above the cutoff frequency, since it may cause multiple modes with different phase velocities to propagate, interfering with each other. The outer diameter is roughly inversely proportional to the cutoff frequency. A propagating surface-wave mode that only involves the central conductor also exists, but is effectively suppressed in coaxial cable of conventional geometry and common impedance. Electric field lines for this TM mode have a longitudinal component and require line lengths of a half-wavelength or longer.
https://en.wikipedia.org/wiki?curid=46380
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FirstLook is a small reconnaissance robot weighing with a top speed of and line-of-sight control range of . It has visible and thermal cameras and infrared sensors to gather and transmit images of buildings, caves, or other locations. It can participate in explosive ordnance disposal by carrying of C4 explosive to an IED. The robot has the ability to mesh together a network of feeds from other robots to extend the range of its sensors. The FirstLook has CBRN detectors and is semi-autonomous, meaning it can perform tasks like course correction and flipping itself over without direct intervention. 100 were bought by JIEDDO in March 2012 and the Pentagon has ordered hundreds more.
https://en.wikipedia.org/wiki?curid=1006355
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The university was the first public higher-education institution in Texas; it opened for classes on October 4, 1876, as the Agricultural and Mechanical College of Texas (A.M.C.) under the provisions of the 1862 Morrill Land-Grant Act. In the following decades, the college grew in size and scope, expanding to its largest enrollment during WWII before its first significant stagnation in enrollment post-war. Enrollment grew again in the 1960s under the leadership of President James Earl Rudder, during whose tenure, the college desegregated, became coeducational, and ended the requirement for participation in the Corps of Cadets. In 1963, to reflect the institution's expanded roles and academic offerings, the Texas Legislature renamed the college Texas A&M University; the letters "A&M" were retained as a tribute to the university's former designation. As of 2021, Carnegie Classification of Institutions of Higher Education lists Texas A&M among "R1: Doctoral Universities – Very high research activity".
https://en.wikipedia.org/wiki?curid=29927
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Measurement of aortic PWV provides some of the strongest evidence concerning the prognostic significance of large artery stiffening. Increased aortic PWV has been shown to predict cardiovascular, and in some cases all cause, mortality in individuals with end stage kidney disease, hypertension, diabetes mellitus and in the general population. However, at present, the role of measurement of PWV as a general clinical tool remains to be established. Devices are on the market that measure arterial stiffness parameters (augmentation index, pulse wave velocity). These include Complior, CVProfilor, PeriScope, Hanbyul Meditech, Mobil-O-Graph NG, BP Plus (Pulsecor), PulsePen, BPLab Vasotens, Arteriograph, Vascular Explorer, and SphygmoCor.
https://en.wikipedia.org/wiki?curid=8498126
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In humans, CXCL12 has been implicated in a wide variety of biomedical conditions involving several organ systems. Furthermore, CXCL12 signaling in conjunction with CXCR7 signaling has been implicated in the progression of pancreatic cancer. In the urinary tract system, methylation of the CXCL12 promoter and expression of PD-L1 may be powerful prognostic biomarkers for biochemical recurrence in prostate carcinoma patients after radical prostatectomy, and further studies are ongoing to confirm if CXCL12 methylation may aid in active surveillance strategies. In the field of oncology, melanoma associated fibroblasts are stimulated by stimulation of the A2B adenosine receptor followed by stimulation of fibroblast growth factor and increased expression of CXCL12.
https://en.wikipedia.org/wiki?curid=960559
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The French government had initially ordered a total of 34 NH90 TTHs for the French Army Light Aviation and 27 NFH for the Navy. Both versions will be named "Caïman" and final assembly will be carried out by Airbus Helicopters. The French Army had intended to buy 68 NH90; however, the April 2013 defence review could have cancelled the contract for the second batch of 34. Under the "Bonn rebate" deal, France receives a 12% discount on its 68 Army helicopters; a November 2012 Senate report put the French TTH per unit price at €28.6M after discount, set on the assumption of total orders of 605 aircraft by 2020. Cuts to France's order would result in workshare reallocation; possibly including French Navy NFH90s being assembled in Italy and Fokker performing maintenance of French TTHs. On 29 May 2013, France formally ordered the second batch of 34 NH90 TTHs for just under €1 billion. In January 2016, France placed an order for six additional NH90 TTHs.
https://en.wikipedia.org/wiki?curid=513911
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Conservative treatment of isolated medial knee injuries (grades I-III) begins with controlling swelling and protecting the knee. Swelling is managed well with rest, ice, elevation, and compression wraps. Protection can be performed using a hinged brace that stabilizes against varus and valgus stress but allows full flexion and extension. The brace should be worn for the first four to six weeks of rehabilitation, especially during physical exercise to prevent trauma to the healing ligament. Stationary bike exercises are the recommended exercise for active range of motion and should be increased as tolerated by the patient. Side-to-side movements of the knee should be avoided. The patient is allowed to bear weight as tolerated and should perform quadriceps strengthening exercises along with range of motion exercises. The typical return-to-play time frame for most athletes with a grade III medial knee injury undergoing a rehabilitation program is 5 to 7 weeks.
https://en.wikipedia.org/wiki?curid=36131822
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At the time, microprocessor design was plateauing at the 100,000 transistor level because the tools available to the designers were simply unable to deal with more complex designs. 16-bit and 16/32-bit designs were coming to market, but beyond that seemed too difficult and expensive to contemplate. Mead and Conway felt that there was no theoretical problem impeding progress, simply a number of practical ones, and set about solving these in order to make much more complex designs possible. Simply put, the solution was to simplify, simplify, simplify, inventing new practical rules-of-thumb for designers and applying computers to the problems that were larger. This process was aided by the recent introduction of depletion mode NMOS logic, which greatly simplified the conceptual model of the active elements.
https://en.wikipedia.org/wiki?curid=3548726
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Far more important is that he was one of the first to postulate the existence of substances, now known as hormones, secreted into the bloodstream to affect distant organs. In particular, he demonstrated (in 1856) that removal of the adrenal glands resulted in death, due to lack of essential hormones. At age 72, at a meeting of the "Societé de Biologie" in Paris, Brown-Séquard reported that hypodermic injection of a fluid prepared from the testicles of guinea pigs and dogs leads to rejuvenation and prolonged human life. It was known, among scientists, derisively, as the "Brown-Séquard Elixir". A Vienna medical publication quipped dismissively: "The lecture must be seen as further proof of the necessity of retiring professors who have attained their threescore and ten years."
https://en.wikipedia.org/wiki?curid=1311821
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Laboratory investigations of the stability of multiple-machine systems were constrained by the use of direct-operated indicating instruments (voltmeters, ammeters, and wattmeters). To ensure that the instruments negligibly loaded the model system, the machine power level used was substantial. Some workers in the 1920s used three-phase model generators rated up to 600 kVA and 2300 volts to represent a power system. General Electric developed model systems using generators rated at 3.75 kVA. It was difficult to keep multiple generators in synchronism, and the size and cost of the units was a constraint. While transmission lines and loads could be accurately scaled down to laboratory representations, rotating machines could not be accurately miniaturized and keep the same dynamic characteristics as full-sized prototypes; the ratio of machine inertia to machine frictional loss did not scale.
https://en.wikipedia.org/wiki?curid=38433617
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After leaving NASA, Aldrin continued to advocate for space exploration. In 1985 he joined the University of North Dakota (UND)'s College of Aerospace Sciences at the invitation of John D. Odegard, the dean of the college. Aldrin helped to develop UND's Space Studies program and brought Dr. David Webb from NASA to serve as the department's first chair. To further promote space exploration, and to commemorate the 40th anniversary of the first lunar landing, Aldrin teamed up with Snoop Dogg, Quincy Jones, Talib Kweli, and Soulja Boy to create the rap single and video "Rocket Experience", proceeds from which were donated to Aldrin's non-profit foundation, ShareSpace. He is also a member of the Mars Society's Steering committee.
https://en.wikipedia.org/wiki?curid=65777
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In 1849, Louis Pasteur resolved a problem concerning the nature of tartaric acid. A solution of this compound derived from living things (to be specific, wine lees) rotates the plane of polarization of light passing through it, but tartaric acid derived by chemical synthesis has no such effect, even though its reactions are identical and its elemental composition is the same. Pasteur noticed that the crystals come in two asymmetric forms that are mirror images of one another. Sorting the crystals by hand gave two forms of the compound: Solutions of one form rotate polarized light clockwise, while the other form rotate light counterclockwise. An equal mix of the two has no polarizing effect on light. Pasteur deduced that the molecule in question is asymmetric and could exist in two different forms that resemble one another as would left- and right-hand gloves, and that the organic form of the compound consists of purely the one type.
https://en.wikipedia.org/wiki?curid=39774
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Kimura worked on a wide spectrum of theoretical population genetics problems, many of them in collaboration with Takeo Maruyama. He introduced the "infinite alleles", "infinite sites", and "stepwise" models of mutation, all of which would be used widely as the field of molecular evolution grew alongside the number of available peptide and genetic sequences. The stepwise mutation model is a "ladder model" that can be applied to electrophoresis studies where homologous proteins differ by whole units of charge. An early statement of his approach was published in 1960, in his "An Introduction to Population Genetics". He also contributed an important review article on the ongoing controversy over genetic load in 1961.
https://en.wikipedia.org/wiki?curid=645327
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In the early 1960s, when Europe and America were establishing geostationary communication satellites, the Russians found these orbits unsuitable. They were limited in the amount of rocket power available and it is extremely energy intensive to both launch a satellite to 40,000 km, and change its inclination to be over the equator, especially when launched from Russia. Additionally geostationary satellites give poor coverage in polar regions, which consists of a large portion of Russian territory. As a result, OKB-1 sought a less energy-consuming orbit. Studies found that this could be achieved using a large elliptical orbit, with an apogee over Russian territory. The satellite's name, "quick as lightning", is in reference to the speed with which it passes through the perigee.
https://en.wikipedia.org/wiki?curid=616348
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A leading pioneer in long-term multidisciplinary ecological studies, Likens examines energy flow and biogeochemical flux models in the ecosystems of forests, streams and lakes. Likens is best known for leading the team of scientists that discovered acid rain in North America, and connected fossil fuels with increasing acidity of precipitation. In addition to its scientific impact, this work has influenced public debate and governmental policy, particularly the United States Congress's Clean Air Act Amendments of 1990.
https://en.wikipedia.org/wiki?curid=3782916
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From the late-1960s to the mid-1980s, under the leadership of M. Maceo Nance, the campus experienced unprecedented growth in the form of new academic buildings, such as Nance Hall (1974) and Belcher Hall (1986), new residence halls, such as Sojourner Truth Hall (1972), which, at 14 stories, is the tallest building in Orangeburg County, and a new library building (1968), not to mention enlargements and renovations of existing facilities. The school also opened the I.P. Stanback Museum & Planetarium, which is the only facility of its kind on a historically black university campus in the United States. After Nance's retirement in 1986, Albert Smith assumed the office of the school's president and, among other achievements, created an honors college in 1988.
https://en.wikipedia.org/wiki?curid=574357
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Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. During pregnancy, angiopoietins act complementary to the VEGF system and contribute to endothelial cell survival and the remodeling of vessels. Few studies have examined the role of angiopoietins in human pregnancy complications like preeclampsia and intrauterine growth restriction (IUGR).
https://en.wikipedia.org/wiki?curid=10345384
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While the H11 was popular with hard-core hobbyists, Heath engineers realized that DEC's low-end PDP-11 microprocessors would not be able to get Heath up the road to more powerful systems at an affordable price. Heath/Zenith then designed a dual Intel 8085/8088-based system dubbed the H100 (or Z-100, in preassembled form, sold by ZDS). The machine featured advanced (for the day) bit mapped video that allowed up to 640 x 512 pixels of 8 color graphics. The H100 was interesting in that it could run either the CP/M operating system, or their OEM version of MS-DOS named Z-DOS, which were the two leading business PC operating systems at the time. Although the machine had to be rebooted to change modes, the competing operating systems could read each other's disks.
https://en.wikipedia.org/wiki?curid=618552
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A Crookes tube is a sealed glass container in which two electrodes are separated by a vacuum. When a voltage is applied across the electrodes, cathode rays are generated, creating a glowing patch where they strike the glass at the opposite end of the tube. Through experimentation, Thomson discovered that the rays could be deflected by an electric field (in addition to magnetic fields, which was already known). He concluded that these rays, rather than being a form of light, were composed of very light negatively charged particles he called "corpuscles" (they would later be renamed electrons by other scientists). He measured the mass-to-charge ratio and discovered it was 1800 times smaller than that of hydrogen, the smallest atom. These corpuscles were a particle unlike any other previously known.
https://en.wikipedia.org/wiki?curid=2844
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CAncer Personalized Profiling by deep Sequencing (CAPP-Seq) is a next-generation sequencing based method used to quantify circulating DNA in cancer (ctDNA). The method was introduced in 2014 by Ash Alizadeh and Maximilian Diehn’s laboratories at Stanford, as a tool for measuring Cell-free tumor DNA which is released from dead tumor cells into the blood and thus may reflect the entire tumor genome. This method can be generalized for any cancer type that is known to have recurrent mutations. CAPP-Seq can detect one molecule of mutant DNA in 10,000 molecules of healthy DNA. The original method was further refined in 2016 for ultra sensitive detection through integration of multiple error suppression strategies, termed integrated Digital Error Suppression (iDES). The use of ctDNA in this technique should not be confused with circulating tumor cells (CTCs); these are two different entities.
https://en.wikipedia.org/wiki?curid=49541612
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Promoted to major early in 1916. Hawker was placed in command of the RFC's first (single seater) fighter squadron, Number 24 based at Hounslow Heath Aerodrome and flying the Airco DH.2 pusher. After two fatalities in recent flying accidents, the new fighter, which featured a forward-mounted Lewis machine gun, soon earned a reputation for spinning; its rear mounted rotary engine and sensitive controls made it very responsive. Hawker countered this worry by taking a DH.2 up over the squadron base and, in front of the squadron pilots, put the aircraft through a series of spins, each time recovering safely. After landing, he carefully described to all pilots the correct procedures to recover from a spin. Once the pilots became used to the DH.2's characteristics, confidence in the aircraft rose quickly, as they came to appreciate its manoeuvrability.
https://en.wikipedia.org/wiki?curid=535536
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The syntheses of elements 107 to 112 were conducted at the GSI Helmholtz Centre for Heavy Ion Research in Darmstadt, Germany, from 1981 to 1996. These elements were made by cold fusion reactions, in which targets made of thallium, lead, and bismuth, which are around the stable configuration of 82 protons, are bombarded with heavy ions of period 4 elements. This creates fused nuclei with low excitation energies due to the stability of the targets' nuclei, significantly increasing the yield of superheavy elements. Cold fusion was pioneered by Yuri Oganessian and his team in 1974 at the Joint Institute for Nuclear Research (JINR) in Dubna, Soviet Union. Yields from cold fusion reactions were found to decrease significantly with increasing atomic number; the resulting nuclei were severely neutron-deficient and short-lived. The GSI team attempted to synthesise element 113 via cold fusion in 1998 and 2003, bombarding bismuth-209 with zinc-70; both attempts were unsuccessful.
https://en.wikipedia.org/wiki?curid=77474
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Modern science arose against Aristotelian physics. Geocentric were both Aristotelian physics and Ptolemaic astronomy, which latter was a basis of astrology, a basis of medicine. Nicolaus Copernicus proposed heliocentrism, perhaps to better fit astronomy to Aristotelian physics' fifth element—the universal essence, or quintessence, the aether—whose intrinsic motion, explaining celestial observations, was perpetual, perfect circles. Yet Johannes Kepler modified Copernican orbits to ellipses soon after Galileo Galilei's telescopic observations disputed the Moon's composition by aether, and Galilei's experiments with earthly bodies attacked Aristotelian physics. Galilean principles were subsumed by René Descartes, whose Cartesian physics structured his Cartesian cosmology, modeling heliocentrism and employing "mechanical philosophy". Mechanical philosophy's first principle, stated by Descartes, was "No action at a distance". Yet it was British chemist Robert Boyle who imparted, here, the term "mechanical philosophy." Boyle sought for chemistry, by way of corpuscularism—a Cartesian hypothesis that matter is particulate but not necessarily atomic—a mechanical basis and thereby a divorce from alchemy.
https://en.wikipedia.org/wiki?curid=6727771
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The squadron was activated at RAF Bentwaters, England in October 1978 as the 81st Tactical Fighter Wing changed its mission to close air support and air interdiction, equipped with Fairchild Republic A-10 Thunderbolt IIs, and expanded from three to six operational squadrons. The squadron participated in joint and combined exercises with American and British ground forces and periodically deployed to designated wartime operating bases. The squadron deployed aircraft and personnel to Incirlik Air Base, Turkey for Operation Provide Comfort to support Kurdish relief in Northern Iraq from 6 September to 10 December 1991, 8 April to 10 June 1992, and from 6 August to 30 October 1992.
https://en.wikipedia.org/wiki?curid=17892971
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On 13 February 1904 was born in Heiterthal, not far from Kollbrunn in Tösstal. He attended the Industrial School in Winterthur and in 1923 began his studies at the Department of Agriculture of the ETH. In 1926 he graduated with a diploma as an engineer-agronomist. After a stay in France, he went to Canada where he acquired, besides his work as "farm help" on various Canadian farms, specialized knowledge, as a volunteer in the Seed Branch in Ottawa, in the field of control seeds. In 1929 he joined the line for seed control in Oerlikon. With his work "On the germination Pinus strobus with particular reference to the origin of the seed," he earned his doctorate in 1932 Dr.sc.techn. ETH. In 1949 he became head of the Department of Agronomy at the ETH.
https://en.wikipedia.org/wiki?curid=24746200
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The underlying purpose of the survey was to improve understanding of the phenomenon of "dark energy", proposed as the mechanism for the observed increasing rate of expansion of the universe, contradicting the traditional theories of gravitational attraction. The survey results can be used in conjunction with measurements of Cosmic microwave background (CMB) to provide more accurate estimates of the composition of the universe. The results will also test current theories of gravity by mapping the growth of structure with redshift. Thirdly, detailed analysis of star-formation rates, environments, morphologies and luminosity functions will provide information on galaxy evolution.
https://en.wikipedia.org/wiki?curid=52648154
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Apart from the layers in immediate vicinity of the surface most of the bulk of the ocean is stably stratified. In a few narrow, sporadic regions at high latitudes surface water becomes unstable enough to sink deeply and constitute the deep, southward branch of the overturning circulation (see e.g. AMOC). Eddy diffusion, mainly in the Antarctic Circumpolar Current, then enables the return upward flow of these water masses. Upwelling has also a coastal component owing to the Ekman transport, but Antarctic Circumpolar Current is considered to be the dominant source of upwelling, responsible for roughly 80% of its overall intensity. Hence the efficiency of turbulent mixing in sub-Antarctic regions is the key element which sets the rate of the overturning circulation, and thus the transport of heat and salt across the global ocean.
https://en.wikipedia.org/wiki?curid=7747984
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The shale is made of alternating fine-grained layers of siliceous mudstone (compressed, hardened mud originally made of ground-up silicate rock) and calcisiltite originally animal shells. The calcisiltite layers contain relatively unremarkable shells and occasional non-biomineralized fossils (such as priapulid tubes). The soft-bodied organisms for which the Burgess Shale is famous are fossilized in the mudstone layers, which are between thick, averaging , and have well-defined bases. Opinions vary about how the mudstone layers were produced: perhaps by mudslides from the top of the "Cathedral" limestone platform, when its edge collapsed occasionally; or possibly by storms that created back-currents that abruptly washed large volumes of mud off the platform. Each mudstone layer is the result of one such catastrophe. The Greater Phyllopod Bed, a thick sequence consisting of Walcott's famous "Phyllopod Bed" plus the below that, contains at least 36 layers, deposited over 10 to 100 thousand years, during which the environment was essentially stable.
https://en.wikipedia.org/wiki?curid=22547077
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Pteranodontids are primarily known from the Coniacian to Campanian stages of the Cretaceous in North America and Japan. However, potential Maastrichtian remains have been identified from several other locations, being actually rather common in the Maastrichtian of the Tethys Sea. Beginning in 2016, Nicholas Longrich, David Martill, and Brian Andres presented evidence of several nyctosaurid and pteranodontid species from the latest Maastrichtian age of north Africa, suggesting that both lineages went through an evolutionary radiation in the Tethys region shortly before the K–Pg extinction event. Additionally, later phylogenetic studies imply that they represent a ghost lineage dating much earlier in the Cretaceous. "Volgadraco", previously assumed to be an azhdarchid, has also since been relocated to pteranodontidae.
https://en.wikipedia.org/wiki?curid=7120097
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The political turmoil of the 1960s worked to the field's advantage because mass media scholars began to explore the influence that media had on culture and society. “Growing recognition of the importance of the media by both industry and the public, as well as increasing respect for the field at the university leveled to increased support for new scholarship.” For example, national and international communications conferences started to be held and associations such as the Speech Association of America (now National Communication Association) and International Communication Association (ICA) increased membership. With each year that passed, the number of communication journals published grew rapidly and by 1970 there were nearly one hundred of them published. After 1968, communication studies started to mature into its own discipline and gained respect in developed nations.
https://en.wikipedia.org/wiki?curid=35040464
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An explosion of new knowledge, accumulated mainly over the last 20 years, has proved that lung cancers should be considered an extremely heterogeneous family of neoplasms with widely varying genetic, biological, and clinical characteristics, particularly their responsiveness to the large number of newer treatment protocols. Well over 50 different histological variants are now recognized under the 2004 revision of the World Health Organization ("WHO-2004") typing system, currently the most widely used lung cancer classification scheme. Recent studies have shown beyond doubt that the old clinical classification paradigm of "SCLC vs. NSCLC" is now obsolete, and that correct "subclassification" of lung cancer cases is necessary to assure that lung cancer patients receive optimum management.
https://en.wikipedia.org/wiki?curid=31095138
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This potential future inability to feed the world's population has been a concern since the English political economist Thomas Malthus in the early 1800s, but has become increasingly important recently. Starting at the very end of the twentieth and early twenty-first centuries, this issue became widely discussed in the U.S. because of growing anxieties of a rapidly increasing global population. Agriculture has long been the biggest industry worldwide and requires significant land, water, and labor inputs. At the turn of the twenty-first century, experts questioned the industry's ability to keep up with population growth. This debate led to concerns over global food insecurity and "solving hunger".
https://en.wikipedia.org/wiki?curid=216143
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Type 343 radar is the first generation Chinese fire control radar for large caliber guns, with development begun in 1968, with 720th Research Institute assigned as the develop in October of the same year. Sea trials begun in July 1970 and design completed in 1976, with state certification received in 1979. A total of 12 sets were produced, with first five built by 720th Institute, and production subsequently transferred to Plant 410 in Guizhou in 1982. The radar operates in two bands, X-band is usually used, with Ku-band as backup. The radar can detect and track medium-sized surface target around 30 and 20 km away respectively.
https://en.wikipedia.org/wiki?curid=51044661
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As soon as the car and the engine became reliable, the era of the Lotus and of Jim Clark began. Clark won the title twice in three years, and , the latter being the only occasion to date of a driver winning both the Championship and the Indianapolis 500-Mile Race in the same year. For 1964 Lotus introduced the new Lotus 33 and Ferrari made considerable technological and financial effort to win the title. Ferrari used no less than three different engines in the seasonthe existing V6, a V8 and a flat-12, while Lotus was struggling with the teething troubles of a new car. The title went to John Surtees and Ferrari. Surtees' title was especially notable, as he became the only driver ever to win the World Championship for both cars and motorcycles. The 1965 Mexican Grand Prix, the last race of the 1.5 litres Formula One, saw Richie Ginther give Honda its first victory at the end of the second season for the Japanese newcomer. This was the first victory by a Japanese car and, as of today, the only one by a car powered by a transverse engine.
https://en.wikipedia.org/wiki?curid=640098
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The applications lab was an essential sales tool. When the spectrograph was introduced as a quick and accurate analytical chemistry device, it was met with widespread skepticism. All research facilities had a chemistry department and analytical analysis was done by “wet chemistry” methods. The idea of doing this analysis by physics instrumentation was considered suspect. To overcome this bias, the salesman would ask a prospective customer for a task the customer was doing by “wet methods”. The task would be given to the applications lab and they would demonstrate how accurately and quickly it could be done using the X-ray units. This proved to be a very strong sales tool, particularly when the results were published in the Norelco Reporter, a technical journal issued monthly by the company with wide distribution to commercial and academic institutions.
https://en.wikipedia.org/wiki?curid=1063456
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APP undergoes extensive post-translational modification including glycosylation, phosphorylation, sialylation, and tyrosine sulfation, as well as many types of proteolytic processing to generate peptide fragments. It is commonly cleaved by proteases in the secretase family; alpha secretase and beta secretase both remove nearly the entire extracellular domain to release membrane-anchored carboxy-terminal fragments that may be associated with apoptosis. Cleavage by gamma secretase within the membrane-spanning domain after beta-secretase cleavage generates the amyloid-beta fragment; gamma secretase is a large multi-subunit complex whose components have not yet been fully characterized, but include presenilin, whose gene has been identified as a major genetic risk factor for Alzheimer's.
https://en.wikipedia.org/wiki?curid=1961275
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The main sequence mechanism was unidirectional. This meant that complex programs had to be physically lengthy. A program loop was accomplished by loop unrolling or by joining the end of the paper tape containing the program back to the beginning of the tape (literally creating a loop). At first, conditional branching in the Mark I was performed manually. Later modifications in 1946 introduced automatic program branching (by subroutine call). The first programmers of the Mark I were computing pioneers Richard Milton Bloch, Robert Campbell, and Grace Hopper. There was also a small technical team whose assignment was to actually operate the machine; some had been IBM employees before being required to join the Navy to work on the machine. This technical team was not informed of the overall purpose of their work while at Harvard.
https://en.wikipedia.org/wiki?curid=173857
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The work of Jewish philosopher Jacques Derrida, and in particular his critical method called deconstruction, has frequently been compared to negative theology, and led to renewed interest in apophaticism in the late 20th century, even among continental philosophers and literary scholars who may not have otherwise have been particularly invested in theological issues. Conversely, the perception that deconstruction resembled or essentially was a form of secular negative theology also - according to Derrida himself - took the form of an "accusation" from his critics, implicitly positing both negative theology and deconstruction as being elaborate ways of saying nothing of any substance or importance. However, Derrida strongly repudiated either form of such comparisons for much of his career, arguing that any resemblance is purely superficial, and that the aims of negative theology - to demonstrate the ultimate, incomprehensible, transcendent reality of God - are a form of ontotheology which runs fundamentally counter to deconstruction's aim of purging Western thought of its pervasive metaphysics of presence.
https://en.wikipedia.org/wiki?curid=66975
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On June 7, 1863, a garrison consisting mostly of black troops assigned to guard a supply depot during the Vicksburg Campaign found themselves under attack by a larger Confederate force. Recently recruited, minimally trained, and poorly armed, the black soldiers still managed to successfully repulse the attack in the ensuing Battle of Milliken's Bend with the help of federal gunboats from the Tennessee river, despite suffering nearly three times as many casualties as the rebels. At one point in the battle, Confederate General Henry McCulloch noted The line was formed under a heavy fire from the enemy, and the troops charged the breastworks, carrying it instantly, killing and wounding many of the enemy by their deadly fire, as well as the bayonet. This charge was resisted by the negro portion of the enemy's force with considerable obstinacy, while the white or true Yankee portion ran like whipped curs almost as soon as the charge was ordered.
https://en.wikipedia.org/wiki?curid=15799614
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"Leymus multicaulis" is a relatively easy plant to grow. In northern regions, it is highly recommended to plant "Leymus multicaulis" seeds during the fall season. This allows the seed coat to become more active. If planted during the spring, the seed coat stays inactive and must be mechanically broken. One to two years are required for the manystem wild rye to grow into a mature plant. Seeds are initially weak and develop at slow rates. The seedlings are no match for weeds. It is best to plant a seedling in an area with low concentration of weeds. "Leymus multicaulis" is tolerant of cold weather; this allows the wild rye to continue development as the winter season passes. Once the plant has matured, the manystem wild rye grass can live a long life. The surroundings of the mature "Leymus multicaulis" can influence the lifespan of the plant. For example, if the mature plant is in an area with high concentration of nitrogen, it is in a healthy environment and will have a longer lifespan. If there are high concentrations of salt and low levels of moisture it will not survive very long. The environment of the developing "Leymus multicaulis" plays a major role in the lifespan of the plant.
https://en.wikipedia.org/wiki?curid=36306956
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Islamic buildings initially adapted the skills of a workforce trained in earlier Indian traditions to their own designs. Unlike most of the Islamic world, where brick tended to predominate, India had highly skilled builders well used to producing stone masonry of extremely high quality. Alongside the architecture developed in Delhi and prominent centres of Mughal culture such as Agra, Lahore and Allahabad, a variety of regional styles developed in regional kingdoms like the Bengal, Gujarat, Deccan, Jaunpur and Kashmir Sultanates. By the Mughal period, generally agreed to represent the peak of the style, aspects of Islamic style began to influence architecture made for Hindus, with even temples using scalloped arches, and later domes. This was especially the case in palace architecture. Following the collapse of the Mughal Empire, regional nawabs such as in Lucknow, Hyderabad and Mysore continued to commission and patronize the construction of Mughal-style architecture in the princely states.
https://en.wikipedia.org/wiki?curid=276879
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Marine VHF mostly uses half-duplex non-relayed transmission. Ship to ship communication is over a single radio frequency, while ship to shore uses two frequencies, but typically only one of the parties can transmit at a time. (Not to be confused with simplex communication, for example radio broadcasting, where one party transmits always transmits.) The transceiver is normally in receive mode; to transmit the user presses a "push to talk" button on the set or microphone which turns the transmitter on and the receiver off. Some channels, however, are "duplex" transmission channels where communication can take place in both directions simultaneously when the equipment on both ends allow it. Each full-duplex channel has two frequency assignments. Duplex channels can be used to place calls over the public telephone network for a fee via a marine operator. When full-duplex is used, the call is similar to one using a mobile phone or landline. When half-duplex is used, voice is only carried one way at a time and the party on the boat must press the transmit button only when speaking. This facility is still available in some areas, though its use has largely died out with the advent of mobile and satellite phones. Marine VHF radios can also receive weather radio broadcasts, where they are available.
https://en.wikipedia.org/wiki?curid=508181
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The 122 mm howitzer M1938 (M-30) (GRAU index: 52-G-463) was a Soviet 121.92 mm (4.8 inch) howitzer. The weapon was developed by the design bureau of Motovilikha Plants, headed by F. F. Petrov, in the late 1930s, and was in production from 1939 to 1955. The M-30 saw action in World War II, mainly as a divisional artillery piece of the Red Army (RKKA). Captured guns were also employed later in the conflict by the German Wehrmacht and the Finnish Army. Post World War II the M-30 saw combat in numerous conflicts of the mid- to late twentieth century in service of other countries' armies, notably in the Middle East.
https://en.wikipedia.org/wiki?curid=4109186
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In late August 2009, the government of Chile discovered that the human H1N1/09 virus had jumped, unmutated, to birds, "opening a new chapter in the global epidemic". Top flu and animal-health experts with the WHO and the CDC were monitoring the situation closely. They said the infected turkeys had suffered only mild effects, easing concern about a potentially dangerous development. Chile's turkey meat remained safe to eat, they said, and so far there had been no signs of a potentially dangerous mutation. Virus experts were concerned that a more dangerous and easily transmitted strain could emerge if H1N1/09 combines again with avian flu, which is far more virulent but much less contagious to humans. By October 2009, another outbreak was identified at a turkey breeder in Ontario, Canada.
https://en.wikipedia.org/wiki?curid=22817589
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After independence, Jawaharlal Nehru, the first prime minister of India, initiated reforms to promote higher education and science and technology in India. The Indian Institute of Technology (IIT)—conceived by a 22-member committee of scholars and entrepreneurs in order to promote technical education—was inaugurated on 18 August 1951 at Kharagpur in West Bengal by the minister of education Maulana Abul Kalam Azad. More IITs were soon opened in Bombay, Madras, Kanpur and Delhi as well in the late 1950s and early 1960s along with the regional RECs (now National Institutes of Technology (NIT). Beginning in the 1960s, close ties with the Soviet Union enabled the Indian Space Research Organisation to rapidly develop the Indian space program and advance nuclear power in India even after the first nuclear test explosion by India on 18 May 1974 at Pokhran.
https://en.wikipedia.org/wiki?curid=13141438
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While waiting for NSF to make the decommissioning plans, steps had been taken to try to reduce the load that each of the towers were carrying, including reducing the strain on the backstay support cables for the individual towers. Other plans, such as having helicopters hoisting part of the load while hovering above the telescope, were proposed but deemed too risky. Engineers from UCF had been monitoring the telescope and observed that wires in the backstay cables for the support towers had been breaking at a rate of one or two a day, and estimated that the telescope would soon collapse. In the weekend prior to December 1, 2020, wire strands in the receiver's supporting cables had also been snapping apart at a rapid rate, according to Ángel Vázquez, the director of operations. This culminated in the collapse of the receiver platform at around 6:55 a.m. AST (10:55 UTC) on December 1, 2020, as the second main cable from Tower 4 failed with the other two remaining support cables failing moments later. The collapse of the receiver structure and cables onto the dish caused extensive additional damage. As the receiver fell, it also sheared the tips of the towers which the support cables ran through. Once the main cables from Tower 4 released, the backstay cables, which normally balanced the horizontal component of force from the main cables, pulled the tower outwards and broke off the top. The other two towers, once the force of supporting the platform was released, also had their tips sheared off due to the backstay cable tension. The top of Tower 12 caused some structural damage to other buildings on the observatory as it fell. No injuries from the collapse were reported.
https://en.wikipedia.org/wiki?curid=9013135
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Sometime during the night of January 31February 1, 1954, Armstrong jumped to his death from a window in his 12-room apartment on the 13th floor of River House in Manhattan, New York City. The "New York Times" described the contents of his two-page suicide note to his wife: "he was heartbroken at being unable to see her once again, and expressing deep regret at having hurt her, the dearest thing in his life." The note concluded, "God keep you and Lord have mercy on my Soul." David Sarnoff disclaimed any responsibility, telling Carl Dreher directly that "I did not kill Armstrong." After his death, a friend of Armstrong estimated that 90 percent of his time was spent on litigation against RCA. U.S. Senator Joseph McCarthy (R-Wisconsin) reported that Armstrong had recently met with one of his investigators, and had been "mortally afraid" that secret radar discoveries by him and other scientists "were being fed to the Communists as fast as they could be developed". Armstrong was buried in Locust Grove Cemetery, Merrimac, Massachusetts.
https://en.wikipedia.org/wiki?curid=10315
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Two clades (groups consisting of all taxa that share a common ancestor) of ceratopsid dinosaurs—Centrosaurinae and Chasmosaurinae—are recognized based mainly on the elaborate ornamentation of their skull roofs. In 2010, Sampson and colleagues placed "Kosmoceratops" in the latter group due to the premaxilla having a narial strut and a triangular process, as well as the presence of an elongated squamosal bone. Their phylogenetic analysis found "Kosmoceratops" to be the sister taxon to "Vagaceratops", in a clade grouped with derived chasmosaurines from the latest Campanian and Maastrichtian stages of the Late Cretaceous epoch including "Triceratops", but not closely related to the more basal (or "primitive") "Chasmosaurus". In 2011, paleontologist Jordan C. Mallon and colleagues also found support for the clade containing "Kosmoceratops" and "Vagaceratops", as did paleontologists Steven L. Wick and Thomas M. Lehman in 2013.
https://en.wikipedia.org/wiki?curid=28916285
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Critical social theory in communication, while sharing some traditions with rhetoric, is explicitly oriented toward "articulating, questioning, and transcending presuppositions that are judged to be untrue, dishonest, or unjust."(p. 147) Some work bridges this distinction to form critical rhetoric. Critical theories have their roots in the Frankfurt School, which brought together anti-establishment thinkers alarmed by the rise of Nazism and propaganda, including the work of Max Horkheimer and Theodor Adorno. Modern critical perspectives often engage with emergent social movements such as post-colonialism and queer theory, seeking to be reflective and emancipatory. One of the influential bodies of theory in this area comes from the work of Stuart Hall, who questioned traditional assumptions about the monolithic functioning of mass communication with his Encoding/Decoding Model of Communication and offered significant expansions of theories of discourse, semiotics, and power through media criticism and explorations of linguistic codes and cultural identity.
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In 1993 teams of a collaborative Mongolian-North American expedition (supported by the Mongolian Academy of Sciences and American Museum of Natural History) discovered a new fossil locality of the Djadochta Formation called Ukhaa Tolgod (meaning "Brown Hills"). Like previous localities, Ukhaa Tolgod has yielded a prominent abundance of well-preserved fossils, including high concentrations of mammal, dinosaur, lizard, and egg remains. A vast majority of specimens from this locality are usually found in near-complete articulation. Overall, when compared to other Mesozoic fossil sites, the diversity of fossils in Ukhaa Tolgod is unusually high.
https://en.wikipedia.org/wiki?curid=5676432
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This brain region has been implicated in executive functions, such as planning, decision making, short-term memory, personality expression, moderating social behavior and controlling certain aspects of speech and language. Executive function relates to abilities to differentiate among conflicting thoughts, determine good and bad, better and best, same and different, future consequences of current activities, working toward a defined goal, prediction of outcomes, expectation based on actions, and social "control" (the ability to suppress urges that, if not suppressed, could lead to socially unacceptable outcomes).
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