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1. Introduction {#sec1}
===============
The important recent achievement in Parkinson\'s disease (PD) research has been the identification of several causative and risk genes with their putative functions. Leucine-rich repeat kinase 2 (LRRK2) gene has been distinguishable from other known PD genes with a number of fun... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Medical school is an emotional experience for students. The influence of emotion on cognition is well recognized. Emotions affect learning of complex skills and knowledge and transferring information into new scenarios \[[@CR1]\]. From the psychological and cognitive view it is believed t... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-toxics-07-00005}
===============
Endocrine disruptor compounds (EDCs) are mostly synthetic molecules from industrial origin \[[@B1-toxics-07-00005],[@B2-toxics-07-00005],[@B3-toxics-07-00005]\] but are also some natural molecules \[[@B4-toxics-07-00005],[@B5-toxics-07-00005]\] that are present i... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused by hantaviruses. Each hantavirus tends to be specific to a different rodent or insectivore host \[[@CR1], [@CR2]\]. Two dominant hantaviruses, Seoul virus (SEOV) and Hantaan virus (HTNV), carried by *Rattus norv... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1-1}
============
Tuberculosis (TB) is a common infectious disease in the developing countries. Antitubercular therapy with the first line drugs is very effective and well-tolerated with only few major adverse reactions. Cutaneous adverse drug reactions (CADR) with antitubercular treatment (ATT) can ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-micromachines-10-00324}
===============
Tactile sensors, most commonly referred to as strain and pressure sensors, can collect mechanical property data from the human body and the local environment, and then provide valuable insights into the human health status or artificial intelligence system... | {
"pile_set_name": "PubMed Central"
} |
C-type natriuretic peptide (CNP), the third discovered member of the natriuretic peptide (NP) family, received its name because it shares a common amino acid core structure with the previously isolated cardiac hormones atrial and B-type NPs (ANP and BNP) (reviewed in ([@CIT0001])). However, human and murine genetic stu... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec0005}
===============
In space, microgravity affects the central circulation in humans and induces a number of adaptive changes within the cardiovascular system. Previous investigations showed that the baroreflex sensitivity fluctuates along with altered blood volume distribution \[[@bib0005], [@b... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Plant cell walls are a terrifically important source of raw material for food, fuel, and industrially chemicals ([@B8]). In addition, they are responsible for not only conferring a definitive shape to the cell and enabling overall growth, but it also provides material transportation and... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Competition tends to select for large size of individual offspring, balanced by a relatively smaller total number of offspring^[@CR1]--[@CR8]^. The competitive advantage of large offspring size is generally thought to occur during dominance interactions, such as during interference co... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s0005}
===============
Tarlov cysts are perineural fluid-filled sacs that are usually found in the lumbosacral spine around the junction of peripheral nerve roots and the respective dorsal root ganglia. The cysts are extradural meningeal cysts with collections of cerebrospinal fluid (CSF) within the ... | {
"pile_set_name": "PubMed Central"
} |
Human airway epithelia function in barrier formation, defense against pathogens, and mucociliary clearance ([@b11-ehp-119-784]). They represent the first barrier against airborne environmental pollutants, and they coordinate recruitment of pivotal inflammatory cells in several pathologies, including chronic obstructive... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijerph-17-01164}
===============
Diabetes represents a clustering of heterogeneous risk factors that affects all aspects of quality of life due to the lifetime demands of diabetes care \[[@B1-ijerph-17-01164]\]. Health-related quality of life (HRQoL) refers to a multi-dimensional concept of qual... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Major depressive disorder (MDD) is a disease affecting around 16% of people over the age of 13 in the US^[@CR1]^. This prevalent mood disorder greatly impacts a patient's quality of life and is the leading cause of disability around the world^[@CR2]^. Experiencing stressful events thr... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijerph-17-01067}
===============
Nasolacrimal duct obstruction (NLDO) is the most common cause of childhood epiphora \[[@B1-ijerph-17-01067]\]. Failed canalisation of the distal nasolacrimal duct, associated with a membranous obstruction at the level of Hasner's valve, is the main cause of conge... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1-1}
============
Chicken is the cheapest source of protein available for human consumption, but it cannot tolerate a wide range of climatic variations which affects the production and reproduction. Climate change and animal production always are complementary to each other and its effect on livestoc... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-sensors-15-26039}
===============
A variety of devices have been developed to extract energy from the environment through piezoelectric, electromagnetic and thermoelectric energy conversion \[[@B1-sensors-15-26039],[@B2-sensors-15-26039],[@B3-sensors-15-26039],[@B4-sensors-15-26039],[@B5-sensors... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
There is an increasing interest in studying genotype by environment interactions in terrestrial and aquatic organisms to clarify how different populations might have diverged to become adapted to local habitats, and to understand how populations may respond to human-induced selection. In marine f... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Mussels of the genus *Mytilus* are widespread in both the Northern and Southern Hemispheres and are important components of coastal ecosystems ([@ref-79]; [@ref-68]; [@ref-51]). Mussels are a bivalve species of significant ecological and commercial value worldwide with annual production of 1.... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
Background to Time Pressure {#S1.SS1}
---------------------------
Within modern society, perceived shortage of time is a frequently experienced aspect of daily life ([@B37]; [@B57]; [@B96]). Recognizing this, a range of academic disciplines have investigated time pressure. This breadth... | {
"pile_set_name": "PubMed Central"
} |
[^1]: Academic Editor: Fray Marshall
| {
"pile_set_name": "PubMed Central"
} |
The worldwide incidence of thyroid cancer is increasing ([@bib6]) with considerable international variation in incidence ([@bib28]). Thyroid cancer is an indolent disease often detected by ultrasound of incidentally discovered nodules and this may be due to diagnostic bias rooted in differential access to health care. ... | {
"pile_set_name": "PubMed Central"
} |
There is mounting evidence to support increased thrombo-embolic risk associated with coronavirus disease 2019 (COVID-19) infection. Here, we report a case of COVID-19 complicated by a right ventricular apical thrombus and aortic thrombi.
A 61-year-old woman with type 2 diabetes mellitus, hypertension, and hyperlipidae... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Mosquitoes including *Culex pipiens* are responsible for several serious diseases and able to transmit diseases agents infecting over 600 million people per year[@R1],[@R2]. *Culex pipiens pipiens* are known by their ecologic plasticity which explains their wide geographical distribution (tem... | {
"pile_set_name": "PubMed Central"
} |
Objective
=========
Reduction of β-cell mass is increasingly recognized as one of the main contributing factors to the pathogenesis of type 2 diabetes. Chronic free fatty acid (FFA) exposure has been shown to induce endoplasmic reticulum (ER) stress that may contribute to promoting pancreatic β-cell apoptosis. In the ... | {
"pile_set_name": "PubMed Central"
} |
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![](envhper00385-0158.tif ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Depression has become one of the leading causes of disability worldwide. In 2015, 7.5% of depression patients lived with disability ([@B1]). However, many people living with this condition are not aware of their illness. In some cultures, it is also considered shameful to disclose one's... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
In the research field of drug addiction the mesolimbic dopaminergic system has always received great attention since the evidence that most of the substances of abuse are able to increase dopamine extracellular concentration in the Nucleus Accumbens (Di Chiara and Imperato, [@B13]). Onl... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Uterine artery embolization (UAE) for the treatment of uterine fibroids was first reported in 1995 \[[@CR1]\], and since then, many reports \[[@CR2]--[@CR15]\] have described the risks and benefits of UAE. Some reports \[[@CR12]--[@CR15]\] stated that preoperative UAE can help reduce blee... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
"Homeless" is a term generally conceptualised to refer to a group of individuals who have no regular access to a decent and conventional housing \[[@CR1]\]. However, the concept of decent housing is influenced by local cultural values, hence the difficulty to find a worldwide accepted def... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-sensors-20-02641}
===============
In recent years, the field of indoor localization has increased in popularity due to both the increasing number of applications \[[@B1-sensors-20-02641]\] in domains such as surveillance \[[@B2-sensors-20-02641]\], navigation (both assistive and general purpose)... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
The intervertebral disc (IVD) lies between the vertebral bodies and links them together. The components of the disc are Nucleus pulposus (NP), Annulus fibrosus (AF) and the end-plates. Although the phenotype of IVD cells and the composition of the extracellular matrix (ECM) is still the subject o... | {
"pile_set_name": "PubMed Central"
} |
Current constraints in blood glucose monitoring and insulin delivery technologies limit the ability of most individuals with type 1 diabetes to safely achieve and maintain recommended glucose and hemoglobin A~1c~ (HbA~1c~) targets. Severe hypoglycemia (SH) remains a common side effect of intensive treatment and a major... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The use of bicycles by children is a common and desirable activity in Canadian society. Several types of bicycle helmet legislation for young people have recently been adopted in various Canadian jurisdictions in an attempt to make bicycling a safer activity. In this paper, we examine bicycle... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1_1}
============
Stroke is the fifth leading cause of mortality in the United States. Nearly 90% of all stroke cases are ischemic in nature \[[@B1]\]. Rapid assessment of patient eligibility for intravenous recombinant tissue plasminogen activator (rt-PA) is critical in these cases to re-establish b... | {
"pile_set_name": "PubMed Central"
} |
In the original article, there was a mistake in Figure 1 and Figure 2 as published. The coefficients for the effects of the experimental intervention condition on thought related test anxiety were mistakenly reported as negative even though the coefficients for these effects are positive. The corrected Figure [1](#F1){... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Nowadays, online crowdsourcing is one of the widely used methods for conducting behavioral experiments with large numbers of people. In comparison to the traditional way of performing offline experiments, crowdsourcing on the Internet enables researchers to collect massive amounts of data and r... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the manuscript and its Supporting Information files.
Introduction {#sec001}
============
The improvement of the performance of commercial banks is of great significance for the rational use of financial resources and the enhancement of the comprehensive competitiveness of China's banking ... | {
"pile_set_name": "PubMed Central"
} |
CASE REPORT {#S0001}
===========
A 68-year old woman presented with urge-incontinence, resistant to anticholinergic therapy. Urinalysis revealed a urinary tract infection caused by E. coli and cytology showed several neutrophils, but no malignant cells. Despite treatment with ciprofloxacin, the urge-incontinence persi... | {
"pile_set_name": "PubMed Central"
} |
I. INTRODUCTION
===============
Thyroid carcinoma is rare in children, especially in patients under 10 years of age (1). In Europe, its incidence is estimated at around 1--2 cases per million in children aged 10--14 years compared to 70 cases per million in adults (2). The incidence rate is higher in females than in m... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
It has been well established that the cyclical development of the mammary gland in mammals represents a valuable model of the processes underlying cell differentiation for the dynamic remodeling of the organ and of its function, in this case, the production and secretion of milk. This... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Compared with endoscopic mucosal resection (EMR) for early gastric cancer (EGC), endoscopic submucosal dissection (ESD) has considerable advantages regarding rates of en-bloc resection, curative resection, and local recurrence [@JR221-1] [@JR221-2] [@JR221-3] [@JR221-4] [@JR221-5]. EMR has su... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Aggressive mature B-cell lymphomas harboring concurrent translocations of 8q24/*MYC* mainly with 18q21/*BCL2* are called "double-hit lymphomas (DHL)" now referred to as "high grade B-cell lymphoma with *MYC* and *BCL2* and/or *BCL6* rearrangements (DH-HGBL)" according to the current World Hea... | {
"pile_set_name": "PubMed Central"
} |
Case presentation
=================
A 46-year-old Caucasian woman presented to the gynaecology outpatient\'s department complaining of menorrhagia, bladder pressure and a feeling of heaviness in the pelvis. She had recently also started experiencing deep dyspareunia. She reported no bowel or constitutional symptoms.
... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Working memory enables us to remember, manipulate, and reorganize information for short periods of time (Salthouse et al., [@B46]; Baddeley, [@B2], [@B3]). This executive memory process is fundamental for everyday life and is known to decline with advanced age (Li et al., [@B27]; Gazzal... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Education level is one indicator of socioeconomic position which, in several countries including South Korea, is provided though death certificate data. Its validity determines the usefulness of death certificate data for exploring the association between socioeconomic position and mortality \[[@... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Coronary heart disease is one of the leading causes of mortality in the world today (MacKay & Mensah, [@CR27]; Murray & Lopez, [@CR31]), and although new cardiac treatments have helped fight coronary heart disease in recent years, an estimated 1/3 of coronary heart disease risk factor... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Airway stenosis is a potentially life-threatening condition, which may be caused by tumor invasion or benign diseases, such as, endotracheal intubation injury, endobronchial tuberculosis, and thoracic trauma. Most of these patients may be too sick to undergo definitive open surgery or m... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
During meiosis, the accurate segregation of chromosomes relies on the formation of crossovers (COs) and sister chromatid cohesion \[[@pbio.1002412.ref001]\]. COs are produced by homologous recombination (H... | {
"pile_set_name": "PubMed Central"
} |
1.. Introduction {#s1}
================
Helminths have plagued human beings even before recorded history. Today, it is estimated that roughly one-third of the almost 3 billion people who live on less than 2 USD per day in developing regions of sub-Saharan Africa, Asia and the Americas are infected with one or more spe... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
In multiple sequence alignments, information emerges as to which residues positions are important to the nature of a protein family, versus which vary freely but could be assigned undue importance during the scoring of pairwise alignments. From these multiple alignments, profile hidden Markov... | {
"pile_set_name": "PubMed Central"
} |
Suberin is among the most recalcitrant plant molecular structures in soils ([@b31-27_36]). Suberin forms a protective barrier in tissues such as woody stems, roots and underground storage organs which undergo secondary growth ([@b10-27_36]). This barrier controls the flux of water and also protects plant tissues agains... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Multilevel inverters have generally functioned as an AC voltage synthesizer to create a quasi-sinusoidal voltage i.e., rough sinusoidal waveform with desired steps using several DC power supplies \[[@bib1]\]. Hence, high number of switching components has let the multilevel inve... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Left atrial (LA) size as assessed by echocardiography has been shown to have prognostic value in patients with dilated cardiomyopathy (DCM). More recently cardiac magnetic resonance (CMR) imaging studies have reported that the presence of left ventricular mid-wall late gadolinium enhancement ... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec005}
============
Lung transplantation is an established therapeutic option for patients with various types of end-stage lung disease. Internationally, the annual number of bilateral lung transplants (BLTs) is greater than ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
The health and progress of any society largely depends on the health of its women. Women experience many biological changes throughout their life that have a significant impact on their health, including pregnancy and lactation.[@CIT0001] Pregnancy changes women's lifestyle and they ... | {
"pile_set_name": "PubMed Central"
} |
Related literature {#sec1}
====================
For general background to the title compound, see: Rivera *et al.* (2010[@bb6]). For related structures, see: Rivera *et al.* (2010[@bb6], 2011[@bb5]); Silversides *et al.* (2006[@bb7]).
Experimental {#sec2}
==============
{#sec2.1}
### Crystal data {#sec2.1.1}... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Many fundamental questions concerning the mechanisms of self-renewal and differentiation of stem cells are addressed using *Drosophila* oogenesis as a model^[@CR1]^. *Drosophila* ovaries consist of ovarioles, chains of egg chambers connected to the germarium, which houses germline ste... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
According with the definition of Abrams et al. \[[@CR1]\], which is accepted and adopted also by recent clinical and epidemiological studies \[[@CR2], [@CR3]\], urinary incontinence (UI) is the condition in which an involuntary loss of urine occurs, which is well identifiable and can crea... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Congenital nephrogenic diabetes insipidus (NDI) is a rare disease caused by genetic mutations in *AVPR2* or *AQP2* ([@r1]). *AVPR2* is located at the Xq28 locus, and it encodes arginine vasopressin receptor 2 (AVPR2). Mutations in *AVPR2* have been associated with X-linked NDI. *AQP2* i... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#j_bjmg-2019-0017_s_001}
============
Alexander disease (AxD) is a rare autosomal dominant leukodystrophy with three clinical subtypes: infantile, juvenile and adult. The neonatal forms were also described
\[[@j_bjmg-2019-0017_ref_001], [@j_bjmg-2019-0017_ref_002], [@j_bjmg-2019-0017_ref_003], [@j_bjmg-... | {
"pile_set_name": "PubMed Central"
} |
Kin selection theory predicts that individuals should behave less aggressively (enhanced social tolerance) or more amicably toward closer kin than less related individuals ([@zoy082-B22], [@zoy082-B23]). In species that live in family groups, individuals may simultaneously gain indirect and direct benefits from helping... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Cancer is fundamentally a disease of genomic origin. Alterations in genes and regulatory elements critical to cell cycle control lead to uncontrolled cell growth and proliferation, the common signature of all cancers. Such events can cause amplification or mutational activation of oncogenes \[[@B... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Breast cancer is the most common cancer diagnosed in women, with an estimated 1.7 million new cases per year worldwide^[@CR1]^. Molecular genetics studies have classified breast cancer into four major subtypes based on gene expression profiles: luminal A, luminal B, HER2-positive, and... | {
"pile_set_name": "PubMed Central"
} |
O.S. & F.D. contributed equally to the manuscript.
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this art... | {
"pile_set_name": "PubMed Central"
} |
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![](brmedchirj27... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
The canonical Wnt/β-catenin signaling pathway plays pivotal roles not only in early embryogenesis but also in stem cell homeostasis and tumorigenesis [@pone.0063378-Clevers1]. The activation of Wnt signaling results in the stabilization of β-catenin through inhibition of glycogen syntha... | {
"pile_set_name": "PubMed Central"
} |
Following millennia of clinical medicine\'s efforts to embrace personalized, more effective and kinder treatments, arguably, it is the lessons garnered from patients with chronic myeloid leukemia (CML) in the chronic phase (CP) that appear to be moving us closer to the prospect of precision cancer medicine.^[@R1]^ The ... | {
"pile_set_name": "PubMed Central"
} |
On-demand or environmentally triggered disassembly of polymers is a widely sought-after goal, as such materials would be tremendously useful in a broad range of industries, including healthcare, cosmetics, agriculture, and electronics.^[@cit1],[@cit2]^ Despite this, few synthetic polymers degrade with high sensitivity ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Human mitochondrial diseases affecting the oxidative phosphorylation (OXPHOS) system can result from a large number of different mutations, both in the nuclear genome or in the maternally inherited mitochondrial DNA (mtDNA) [@pone.0008549-Schon1], [@pone.0008549-Smeitink1]. Environmenta... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The mammary gland is an interesting model for studying gene expression since this organ experiences different cycles of differentiation and regression during adult life. In eukaryotes, gene expression is a complex process that involves DNA methylation, chromatin modification, imprinting, and ... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-behavsci-10-00114}
===============
Healthy parent--child interactions provide opportunities for children to accrue rich social experiences for development \[[@B1-behavsci-10-00114],[@B2-behavsci-10-00114],[@B3-behavsci-10-00114],[@B4-behavsci-10-00114],[@B5-behavsci-10-00114],[@B6-behavsci-10-00... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-jfb-09-00008}
===============
Building an electronic device out of single molecules represents the ultimate miniaturization of active electronic components. Not only could such molecular-scale devices conceivably increase circuit density by thousands of folds compared to today's state of the art... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#Sec1}
============
The potential influence of excipients on the performance of solid oral dosage forms is a topic of great interest in terms of pharmaceutical Quality by Design (QbD). Further to their intended use, excipients may affect the properties and performance of final dosage forms leading to bat... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
As a member of the nuclear receptor family, the androgen receptor (AR) plays an important role in breast cancer, and has been identified as a biomarker for a specific molecular subtype of breast cancer. The AR gene expression profile can be used for further classifying receptor-negative t... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s0001}
============
Rising healthcare costs and the quadruple burden of disease demand critical scrutiny of healthcare organisation and practice globally. It is estimated that by 2020 chronic diseases will account for 73% of all deaths and 60% of the global burden of disease.^[@CIT0001]^ The growing bur... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Dietary guidance is consistent in recommending greater consumption of fruit and vegetables to promote health. Indeed, the 2015 Dietary Guidelines Advisory Committee report noted that greater fruit and vegetable intake was the only characteristic of dietary patterns that was consistently ident... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec0005}
============
Cancers of the kidney and renal pelvis account for approximately 3.5% of all new cancer cases in the United States and are responsible for 3.9 deaths per 100,000 individuals per year. Most arise in the kidney, and are commonly described as renal cell carcinoma (RCC). The majority (... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Taxol is a diterpenoid natural product, had been originally isolated and chemically identified from the bark of Pacific yew *Taxus brevifolia*^[@CR1]^. It has been approved by FDA in 1992 as a broad-spectrum drug for treatment of refractory ovarian, breast, melanoma, pancreatic and lu... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in several brain diseases as a detrimental factor playing a causal or exacerbating role in neuroinflammation and neurodegeneration \[[@B1]-[@B7]\]. Elevated levels of IL-6 are typical for brains from animal models or humans suffering from mu... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s0005}
===============
All live cells have a stable transmembrane potential (TMP) voltage differential across the cell membrane when the cell is at rest. This is the result of the accumulated ion concentrations within the cell compared to that outside the membrane. Electrically active cells, such as ... | {
"pile_set_name": "PubMed Central"
} |
All data are hosted by the Harvard Dataverse (<https://dataverse.harvard.edu/dataset.xhtml?persistentId=doi:10.7910/DVN/HZDQ70>). Data are also hosted at IRRI (<http://ricestat.irri.org/fhsd/php/survey.php>) under Project ID: 98.
Introduction {#sec001}
============
Rice *(Oryza sativa* L.*)* is one of the most import... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the manuscript and its Supporting Information files.
Introduction {#sec001}
============
Nest site selection is a key component of successful breeding in seabirds \[[@pone.0212668.ref001]\]. Optimal conditions at a breeding site are shaped by multiple factors, including both abiotic and b... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Rhabdomyolysis is the breakdown of skeletal muscle that can rapidly progress to acute renal failure or death. It is important to make a rapid diagnosis and initiate treatment for rhabdomyolysis in order to decrease morbidity and mortality. To date there are no reports in the emergency medicin... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
L-carnitine is an essential factor for the membrane transport of acyl-CoA compounds, particularly for the intramitochondrial transport of long-chain fatty acids \[[@ref1]\]. L-carnitine also helps to remove by-products of fatty acid metabolism and other toxic compounds from the cell... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-biosensors-10-00039}
===============
Capillary-driven flow microfluidics is a type of microfluidics which allows fluid movements into microchannels via capillary forces and does not require internal/external expensive and complicated fluid management mechanisms \[[@B1-biosensors-10-00039]\]. Thi... | {
"pile_set_name": "PubMed Central"
} |
Background {#s1}
==========
Developing a drug from first-in-human studies to Food and Drug Administration (FDA) approval is a lengthy and costly process ([@CIT0006]). In an effort to streamline therapeutic development, recent efforts have sought to repurpose clinically-available drugs by detecting heretofore unrecogni... | {
"pile_set_name": "PubMed Central"
} |
Erratum to: Clin Transl Oncol (2015) 17:996--1004 DOI 10.1007/s12094-015-1456-y {#Sec1}
===============================================================================
The affiliation of the author A. Custodio was rendered wrongly. The correct affiliation is: Medical Oncology Department, Hospital Universitario La Paz,... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .288}
{#sp2 .289}
| {
"pile_set_name": "PubMed Central"
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Introduction {#Sec1}
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Excessive use of antibiotics in general and in veterinary medicine has resulted in the contamination of the natural environment with these substances (EEA [@CR20]). Of all the veterinary antibiotics (VAs), only 20% are used to treat infections; the other 80% are used to prevent diseas... | {
"pile_set_name": "PubMed Central"
} |
Overview of cancers
===================
Bladder cancer
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Bladder cancer refers to any of several types of malignant growths of the urinary bladder, about 90--95% of which are transitional cell carcinomas (TCC); the remaining are squamous cell carcinomas and adenocarcinomas ([@bib50]). Every year in the U... | {
"pile_set_name": "PubMed Central"
} |
The authors confirm that all data underlying the findings are fully available without restriction. Raw data are not suitable for public deposition as they contain identifying human information. Data are available upon request from the corresponding author.
Introduction {#s1}
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In Western countries multiple... | {
"pile_set_name": "PubMed Central"
} |
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/anae.15220
| {
"pile_set_name": "PubMed Central"
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Introduction {#sec1-1}
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Ununited fractures of clavicle are occasionally seen in adults, but are rarely found in children\[[@ref1][@ref2]\]. Post-traumatic non-union of the clavicle is a rare complication in adulthood with a frequency of about 1%. This condition is also exceptional in children, despite the ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
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Microbial biomass in marine sediments accounts for 0.18−3.6% of Earth's total biomass (4.1 petagram carbon), and their community composition is highly diverse due to variation in oxygen concentrations in the overlying water, sediment carbon content, and sediment depth [@pone.0096219-Kal... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
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Left atrial and ventricular volumes and ejection fraction are important diagnostic and prognostic parameters, widely used in daily practice. Indication for cardiac surgery in patients with valvular abnormalities such as bicuspid aortic valve disease, relies heavily on accurate left ve... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s001}
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D[espite neonatal polycythemia]{.smallcaps} being more common in infants born to mothers with gestational diabetes mellitus (GDM) than in infants in the general population---to our knowledge---no published study has assessed the hematopoietic stem and progenitor cell (HSPC) population... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
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BREAST CANCER {#s2}
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At present, one in eight women in the United States will develop breast cancer \[[@R1]\]. Recent advances in breast cancer detection and treatment have decreased the mortality rate of breast cancer \[[@R1]\] but the success of treatment relies largely ... | {
"pile_set_name": "PubMed Central"
} |
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