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INTRODUCTION
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Ro ribonucleoproteins (RNPs) are low-abundance autoantigens that are frequently targeted by antibodies from patients with connective tissue diseases, but not from animals with spontaneous autoimmune diseases ([@b1],[@b2]). Ro RNPs consist of the non-covalent association of short (70--115 nt) ... | {
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1. Introduction {#sec1}
===============
Arteries are dynamic vascular conduits that can remodel in response to atherosclerosis [@bib1]. Cardiovascular disease is characterized by thickening of the intima-media portion of the vessel and plaque formation, reduced vessel elasticity and increased vessel size. The process ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
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Due to its high prevalence and associated morbidity and mortality, influenza is a major public health concern that affects millions of Canadians every year. It is estimated that every year between 2000 and 8000 Canadians die of influenza or its complications, depending on the seasonal severit... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
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Segmentation is one of the fundamental digital image processing operations. It is used ubiquitously across all scientific and industrial fields where imaging has become the qualitative observation and quantitative measurement method. Segmentation design, evaluation, and computational scal... | {
"pile_set_name": "PubMed Central"
} |
Background
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Trabeculectomy remains the standard surgical procedure used to treat open angle glaucoma; however, it is commonly associated with complications such as hypotony and cataract progression. Nonpenetrating glaucoma surgeries (NPGS) has been developed in recent years in order to improve its safety ove... | {
"pile_set_name": "PubMed Central"
} |
Related literature {#sec1}
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For the preparation, see: Issidorides & Haddadin (1966[@bb8]). For the biological activity of quinoxaline di-*N*-oxide compounds, see: Amin *et al.* (2006[@bb5]); Edwards *et al.* (1975[@bb6]); Glazer & Chappel (1982[@bb7]).
Experimental {#sec2}
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"pile_set_name": "PubMed Central"
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Introduction
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Cardiovascular diseases (CVD) represent the main cause of mortality, morbidity, and health resource utilization in elderly individuals.[@b1-cia-7-463] Strategies for confronting these diseases involve the acknowledgment of factors associated with higher risk of arteriosclerotic disease and th... | {
"pile_set_name": "PubMed Central"
} |
Background
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Over the past decades, there has been enormous interest in fabricating periodic semiconductor nanostructures, in which the semiconductor nanodot or nanorod array has shown its great potential for future applications in photonic crystals \[[@B1]\], nanoscale transistors \[[@B2]\], field electron e... | {
"pile_set_name": "PubMed Central"
} |
Acetaminophen is an analgesic drug prescribed widely for human patients and sometimes for veterinary patients \[[@r3], [@r5], [@r6]\]. Although it is generally safe, an overdose of acetaminophen can cause severe liver failure and significant mortality \[[@r5], [@r6]\]. Liver injury is believed to be caused by the metab... | {
"pile_set_name": "PubMed Central"
} |
Membrane proteins are highly abundant, comprising more than a third of all cellular proteins, but they are structurally under-represented (<http://blanco.biomol.uci.edu/>). To obtain high-resolution structural information on integral membrane proteins remains a great challenge. X-ray crystallography is the primary tool... | {
"pile_set_name": "PubMed Central"
} |
Platinum drug complexes have been in clinical use for three decades and their greatest curative potential is exhibited towards certain subtypes of testicular cancer. The Pt complexes are widely used in cancer chemotherapy but unfortunately their efficacy is limited against the majority of malignancies. The reasons for ... | {
"pile_set_name": "PubMed Central"
} |
It is well known that cetaceans have a unique evolutionary history. They originated from terrestrial tetrapod mammals[@b1][@b2][@b3][@b4], and were eventually distributed into aquatic environments after experiencing a period of semi-aquatic living[@b5][@b6][@b7][@b8][@b9]. Therefore, they have developed unique adaptive... | {
"pile_set_name": "PubMed Central"
} |
**Related research article** Stanek E IV, Cheng S, Takatoh J, Han B-X, Wang F. 2014. Monosynaptic premotor circuit tracing reveals neural substrates for oro-motor coordination. *eLife* **3**:e02511. doi: [10.7554/eLife.02511](http://dx.doi.org/10.7554/eLife.02511)
**Image** Premotor neurons can project to motoneurons ... | {
"pile_set_name": "PubMed Central"
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Original questionnaires, data and syntax for all three studies are available at the Open Science Framework <https://osf.io/agqem/>.
Introduction {#sec004}
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According to estimates by the World Health Organization (WHO), vaccination saves 2 to 3 million lives worldwide every year \[[@pone.0208601.ref001]\].... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Congestive heart failure (CHF) is common in North America with the prevalence being approximately 2% in adults older than 45 years \[[@B1]\]. While coronary artery disease (CAD) is a major contributor to the development of congestive cardiac failure in hypertensive patients in W... | {
"pile_set_name": "PubMed Central"
} |
Signaling pathways can be a dizzying confusion of interlacing kinases, phosphatases, activators, and inhibitors. But with mathematical models, Reinhart Heinrich (Humboldt-University, Berlin, Germany), Benjamin Neel, and Tom Rapoport (Harvard Medical School, Boston, Massachusetts) have injected some transparency into th... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files. No physical datasets were used in this work, only simulations that rely on large MATLAB structures and classes that require custom-made libraries. All method parameters, settings of the simulation, parametric models and software packages neces... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Cervical cancer (CC) is a serious public health problem in China, with \~102,000 new cases estimated according to the National Central Cancer Registry in 2013 ([@b1-ol-0-0-11738]). In addition, CC is the second most common malignant tumor in women worldwide ([@b2-ol-0-0-11738],[@b3-ol-0-0-117... | {
"pile_set_name": "PubMed Central"
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Depression is a disabling mental disorder, which can include symptoms such as sadness, anger, or loss of interest in once enjoyable activities and can interfere with daily life.^[@bibr7-1941738113480464]^ It is characterized by a low mood level for most of the day, nearly every day, for at least 2 weeks.^[@bibr3-194173... | {
"pile_set_name": "PubMed Central"
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1. INTRODUCTION {#acm212771-sec-0005}
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Radiation therapists are usually under pressure when starting a new patient's treatment. It is critical to them to correctly position a patient on a treatment couch and move it to the treatment location. Traditionally, therapists rely on skin tattoos (reference mar... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
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A case presentation is a formal means of communication between health professionals used to convey important clinical information. Components of a full presentation include a patient's chief concern, history of present illness, relevant past medical, family, and social histories, alle... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
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Spatial information plays an essential role in the dynamics of biological or artificial systems. Many studies have been dedicated to network dynamics [@pone.0005919-Newman1] and the patterns of diffusion in ecological systems [@pone.0005919-Rietkerk1] or in unicellular populations [@pon... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
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Actinic keratosis (AK) is a common skin condition associated with cumulative sun exposure. AK lesions possess the risk of progressing to squamous cell carcinoma (SCC) \[[@CR1]--[@CR3]\], which is a common form of non-melanoma skin cancer (NMSC). Whereas AK lesions may regress spontaneousl... | {
"pile_set_name": "PubMed Central"
} |
Background
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How different are cells grown *in vitro*from cells that are part of a tissue? Human tissues and tumors are complex and heterogeneous as they are composed of different cell types that influence each other through paracrine signaling pathways and interactions with extracellular matrix (ECM). Cell l... | {
"pile_set_name": "PubMed Central"
} |
Introduction
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Prader--Willi syndrome (PWS) is a multisystem genetic disorder caused by a loss of paternally inherited expression on the chromosome 15q11-13. Causes of this disruption can be attributed to maternal uniparental disomy of chromosome 15 (mUPD), a deletion (DEL) of a 5--6 Mb region from paternal... | {
"pile_set_name": "PubMed Central"
} |
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Background {#Sec1}
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Children are a vulnerable group and their wellbeing should always be a priority \[[@CR1]\]. Nevertheless, children have historically been exposed to many medical procedures and treatments without any analgesics since researchers claimed that small children did not feel any pain \[[@CR2]\]... | {
"pile_set_name": "PubMed Central"
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"pile_set_name": "PubMed Central"
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Dear Editor,
We read with great interest the article by Kim et al. ([@B1]), "Novel application of quantitative single-photon emission computed tomography/computed tomography to predict early response to methimazole in Graves\' disease?" In the present article, the authors developed Cox regression prediction models to ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
*Acinetobacter baumannii* had emerged as an important nosocomial and opportunistic pathogen worldwide, especially in intensive care units ([@B27]). *A. baumannii* treatment is difficult because the clinical strains generally show resistance to multiple antibiotics ([@B27]). Because the extens... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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Meningiomas are classified morphologically by the World Health Organization (WHO) grading scheme into three categories ([@B1]). While most meningiomas are benign or grade I, the propensity of certain subtypes to recur following treatment creates a pathological course that can lead to a spectrum of malignant disease.
T... | {
"pile_set_name": "PubMed Central"
} |
Concurrent with the soaring rates of childhood obesity, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common liver disease in children in the U.S. ([@B1]). NAFLD includes a wide spectrum of pathologies, ranging from simple steatosis (also called NAFL) to steatohepatitis (NASH) to fibrosis/cirrhosis (... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Recent success in malaria control in sub-Saharan Africa (SSA) has led to the renewed interest in malaria elimination and eradication \[[@B1],[@B2]\]. In high-transmission areas, elimination may not be possible with currently available tools, but such tools can greatly reduce malaria transmission ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Obesity, particularly visceral obesity, is associated with an increased risk of metabolic diseases, such as dysglycemia (pre-diabetes and type 2 diabetes), dyslipidemia, hypertension, and cardiovascular disease^[@CR1]^. Type 2 diabetes (hereafter referred to as diabetes), which cannot... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
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Unipolar depression is one of the leading contributors to the global burden of disease, with the highest percentage of the burden found in low and middle-income countries (LMICs) \[[@CR1]\]. There is limited epidemiological evidence about depression in Vietnam, but existing studies sugges... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
One of the most noticeable functions of adenosine in the brain is the ability to impose a brake on the central dopaminergic system. This inhibitory role of adenosine is largely mediated by the activation of one subtype of adenosine receptor, the A~2A~ receptor (A2AR), particularly expressed b... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-sensors-19-04835}
===============
Over the next few years, researchers and scientists anticipate that the next communication technology---fifth generation cellular network technology (5G)---will have greater overall capacity and implement a new spectrum \[[@B1-sensors-19-04835]\]. The system cap... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-microorganisms-08-00444}
===============
*Salmonella* is an important cause of foodborne diseases associated with increased morbidity and mortality worldwide \[[@B1-microorganisms-08-00444],[@B2-microorganisms-08-00444]\]. To date, more than 2600 *Salmonella* serotypes have been reported \[[@B3-... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s1}
===============
Agents, be they biological or technical systems, which operate and behave in changing environments require cognitive and behavioral flexibility. Such behavioral flexibility is essential for survival and represents a unique component of intelligence, in particular the ability to sw... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Chronic obstructive pulmonary disease (COPD) is a prevalent chronic respiratory condition that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and lungs to inhaled particles or gases.^[@bib1]^ Current international clinical COPD guidelines s... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
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Mechanical vibrations of the smallest resonators, such as carbon-nanotube-based (CNT-based) nanowires \[[@CR1]--[@CR3]\], semiconducting nanowires \[[@CR4]\], graphenes \[[@CR5]\], and levitated particles \[[@CR6]\], have been a main research subject in the nanoscience community for o... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
Intracranial germ cell tumors (GCTs) account for about 2% of brain tumors in children in India.\[[@ref1]\] Spread of tumor outside the primary site occurs in 10-30% of cases,\[[@ref2]\] however, metastasis outside the central nervous system is rare. We report a case of liver metasta... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
1 Introduction {#sec001}
==============
In many countries, one can observe a growing tendency in the development of road tunnels. Disasters which occurred in tunnels show that safety issues are extremely important \[[@pone.0201732.ref001]\].... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Perovskite solar cell (PSC) stability is still far less than the \~25 years required to enter the mainstream photovoltaic (PV) market^[@CR1]^, despite efficiencies reaching 25.2%^[@CR2]^. Improving environmental stability is a critical step. Recent studies suggest that mixing low-dime... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
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The study of human development and disease requires the use of animal models. No single model system is likely to be able to accurately mimic all human phenotypes, or alone lead to the discovery of drugs with the desired efficacy in humans. The choice of the most appropriate model sys... | {
"pile_set_name": "PubMed Central"
} |
Background
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Early school success is clearly related to later success and health \[[@B1],[@B2]\]. Promoting optimal child health and development increases the likelihood of school success and is therefore important not only for children\'s immediate outcomes, but also for their future. Over the past 20 years,... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Nectar is the principal reward offered by flowering plants to attract pollinators \[[@B1]\]; this sugary solution is secreted from floral organs known as nectaries. The complexity of nectar composition has been revealed through many studies on a wide variety of species. In addition to simple suga... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
We present a 13-week-old female infant with bilateral aniridia, Axenfeld anomaly and unilateral foveal hypoplasia in the absence of other systemic findings. The anterior segment and foveal structures were delineated with spectral domain optical coherence tomography. Her fraternal twin brother... | {
"pile_set_name": "PubMed Central"
} |
Patients with Chronic Obstructive Pulmonary Disease (COPD) suffer from a persistent airflow limitation which, together with commonly experienced extrapulmonary effects and comorbidities, is associated with physical inactivity ([@b12-ijt-08-39]; [@b24-ijt-08-39]; [@b31-ijt-08-39]). An inactive lifestyle might in turn le... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
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The Caesarean delivery (CD) rate continues to rise in many countries worldwide even though this increase does not appear to be associated with improvement in maternal and perinatal mortality or morbidity [@pone.0028060-Belizan1]. Several studies suggested the benefit of multifaceted int... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Fish is an important food item for the increasing world population which is rapidly approaching 7 billion people. Fish, one of the main protein sources, is still predominantly caught from the wild. Fishing operations are highly industrialized and effective, with remotely controlled ne... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
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Radiocarbon (^14^C) is a powerful tracer for ocean ventilation and carbon storage in the past^[@CR1]--[@CR3]^. However, the proxies themselves (e.g., reconstructed ^14^C age or content of seawater with reference to the atmosphere) are uncertain because they require prior knowledge of ... | {
"pile_set_name": "PubMed Central"
} |
###### Strengths and limitations of this study
- For the first time the effect of a well-articulated, manualised palliative care intervention is being studied in a randomised controlled trial in a patient group (glioblastoma multiforme) with a wide range of neurological, psychological and psychiatric symptoms.
- ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Prebiotics and probiotics have been widely studied and applied on the pharmaceutical and food industries due to their health benefits. The global prebiotics and probiotics market is constantly growing partly attributed to consumer awareness of the health benefits of their consumption ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
Perfusion magnetic resonance imaging (MRI) is an important non-invasive tool in human medicine for evaluating cerebral hemodynamics ([@B1]). Two contrast-based perfusion imaging sequences are described: dynamic susceptibility weighted dynamic susceptibility MRI (DSC-MRI) and dynamic con... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Parkinson\'s disease (PD) is the second most common movement disorder and one of the most common neurodegenerative diseases worldwide ([@bib2]). PD is a progressive neurodegenerative disorder with the idiopathic symptoms resulting from the degeneration of dopaminergic neurons. T... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Many Gram-negative bacterial pathogens translocate effector proteins into eukaryotic host cells to modulate host cellular pathways such as defense responses to their own benefit (Raymond et al., [@B71]; Ashida et al., [@B3]; Santos and Finlay, [@B80]; Büttner, [@B10]; Ensminger, [@B28];... | {
"pile_set_name": "PubMed Central"
} |
ANNOUNCEMENT {#s1}
============
Wastewater is a rich reservoir of viral diversity ([@B1], [@B2]). To safeguard public health, discovery efforts can exploit this diversity to identify novel indicators that can track virus removal efficiency through wastewater treatment. Here, we investigated treated wastewater effluent... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1}
============
Telephone emergency services (TES) are an important component of psychosocial health care and suicide prevention strategies across different healthcare systems. Their offer is readily available, usually free of charge and confidential. The International Federation of Telephone Emergen... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
Soil contamination with heavy metals has become a worldwide environmental issue \[[@pone.0172438.ref001]--[@pone.0172438.ref004]\] and there are serious problems with soil heavy metals pollution in China. ... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Hepatitis C infection is one of the major epidemics afflicting young adults with more than 150,000 known infected cases in Australia and a notification rate of \~16,000 cases per year in 2002 \[[@B1]\]. In the United States, HCV remains the most common chronic blood-born infection \[[@B2],[@B3]\]... | {
"pile_set_name": "PubMed Central"
} |
The online version of this article includes supplemental material.
Abbreviations used in this paper: Btz, Barentsz; eIF4E, eukaryotic initiation factor 4E; Exu, Exuperantia; Yps, Ypsilon Schachtel.
Introduction
============
Localization of mRNAs is used by many polarized cells as a means of restricting the distribut... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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Introduction {#s1}
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Crohn\'s disease (CD) is a heterogeneous disorder with differences in severity, location, behavior and age at onset of inflammation. The heterogeneity of the disease has important implications towards clinical management: patients with a more severe disease course might benefit from ear... | {
"pile_set_name": "PubMed Central"
} |
T. Chinnasamy, J. L. Kingsley, F. Inci, P. J. Turek, M. P. Rosen, B. Behr, E. Tüzel, U. Demirci, Adv. Sci. 2018, 5, 1700531 <https://doi.org/10.1002/advs.469>
1. Introduction {#advs469-sec-0010}
===============
Human infertility affects an estimated 15% of couples globally (about 50 million total), and nearly one‐thi... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
DN, which is characterized by progressive albuminuria and a gradual decline in glomerular filtration rate, is a distinct kidney disease that is becoming the single most important cause of end-stage renal disease (ESRD) throughout the world \[[@B1], [@B2]\]. Approximately 30% of ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
*Bacillus anthracis* (*B. anthracis*), the etiological cause of the lethal anthrax disease is a spore-forming Gram-positive bacteria. In nature, *B. anthracis* exists as spores which exhibit notorious environmental resilience, and which are the infective form of the bacterium. The animals mor... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1}
============
In last years, we have witnessed the development of several computational techniques for solid-state (SS) applications that enlarged the possibility of computer simulations in this research field. Various wave-function-based approaches, earlier available for molecular systems only, do... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
A pseudoaneurysm is defined by the loss of integrity of all three layers of the arterial wall. This finding distinguishes it from a true aneurysm, in which the arterial wall is intact but expanded \[[@B1]\]. In comparison to other locations, pseudoaneurysms of the carotid artery... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Food and feed products can be contaminated with toxic metabolites produced by fungi called mycotoxins. Deoxynivalenol (DON) is a mycotoxin produced by the fungus *Fusarium graminearum*. DON is a contaminant of staple crops such as wheat, barley, and maize ([@bib3]). DON causes d... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Late gadolinium enhancement (LGE) is used to evaluate fibrosis of the left atrium (LA) in subjects with atrial fibrillation (AF). LA fibrosis by LGE has been shown to correlate with LA volumes. However, within AF subjects, the association of mitral regurgitation (MR) with LA LGE is not well descr... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#S0001}
============
Significant symptoms of venous occlusion or thrombosis in patients with a pacemaker or implantable cardioverter-defibrillator (ICD) are rarely observed in clinical practice. Most frequently, the diagnosis of occlusion is made accidently or during another procedure related to the impl... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Perfluorocarbons (PFCs) have a long research history as blood substitutes, ^19^F magnetic resonance tracers and ultrasound agents \[[@B1-biosensors-03-00341]\]. PFC nanoemulsions are common formulations for ^19^F magnetic resonance imaging (MRI) of cells *in vivo* \[[@B2-biosensors-03-0... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1}
============
Globally, self-medication was found to be on the rise \[[@cit0001]\]. Self-medication has been defined as \"the taking of drugs, herbs or home remedies on one\'s own initiative, or on the advice of another person, without consulting a doctor\" \[[@cit0002]\]. Major problems related to... | {
"pile_set_name": "PubMed Central"
} |
Abbreviations
=============
H1Histamine receptor 1H2Histamine receptor 2H4Histamine receptor 4MDSCsmyeloid-derived suppressor cellsTAMstumor-associated macrophages
Introduction {#s0001}
============
Selective H2 antagonists such as ranitidine and famotidine are some of the most frequently used drugs for the treatmen... | {
"pile_set_name": "PubMed Central"
} |
Correction to: *Scientific Reports* 10.1038/s41598-019-56070-1, published online 20 December 2019
The original version of this Article contained a typographical error in the spelling of the author Ana Elizabeth Oliveira de Araújo Alves, which was incorrectly given as Ana Nathalia Oliveira de Araújo Alves.
This error ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The field of materials science advances in developing new materials that often require new research to predict their behavior in use. Among dental materials, ceramics are widely used due to high aesthetics and mechanical properties ([@B1]). Thus, in respecting their limitations and following ... | {
"pile_set_name": "PubMed Central"
} |
Assessment of glomerular filtration rate (GFR) is important in the follow-up of patients after receiving a kidney transplant. Many equations based on plasma markers are in use for estimating GFR in different patient groups, but there is still a need for a specific and accurate equation for use in kidney transplant reci... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Nitrile butadiene rubber (NBR) has been widely applied as an oil-resistant rubber, adhesives, coatings, plastics modifiers, and so forth because of its high strength and excellent oil resistance and elastic properties.^[@ref1]−[@ref3]^ However, due to the presence of C=C double ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s0005}
===============
α-amylases (E.C.3.2.1.1) are enzymes known to catalyse the hydrolysis of internal α-1,4-glycosidic linkages in starch into smaller moiety, such as glucose, maltose, etc. Amylases play a significance role in biotechnology which constitutes a varied range of industrial applicatio... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction
===============
Oxidative stress through the generation of reactive oxygen species (ROS) can severely impact the nervous system and related pathways that control immune function and cellular metabolism during aging. ROS are formed through superoxide free radicals, hydrogen peroxide, singlet oxygen, nit... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s1}
============
Historically, sepsis represented one of the major causes of death until the discovery of antibiotics in the early 20th century. However, emerging diseases such as Ebola, H5N1 avian influenza or SARS, together with an increase in antibiotic resistance in previously controllable pathogens... | {
"pile_set_name": "PubMed Central"
} |
About the author
================
Paul Hammersley is the Programme Director for Post Graduate Studies in cognitive behavioural therapy for psychosis at Manchester University\'s COPE Initiative in The United Kingdom. He is also an active therapist specialising in CBT for individuals experiencing severe psychological pr... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Malaria is endemic in many parts of the world, with 216 million reported cases and 445,000 malaria deaths in 91 countries in 2016 according to the World Health Organization \[[@bib1]\]. The illness is caused by *Plasmodium* species and is transmitted by female *Anopheles* mosqui... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
The Ebola virus disease (EVD) epidemic of 2014 is the largest in history accounting for 28,646 cases as of 30^th^ March 2016 \[[@B18]\]. The epidemic started in December 2013 in a village called Gueckedou in the Republic of Guinea with the death of a two-year-old boy. In Liberia... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
Fungal rhino-sinusitis is a type of chronic rhino-sinusitis (CRS) and has five clinico-pathological variants. Three of these are tissue invasive and include acute necrotizing (fulminant), chronic invasive and granulomatous invasive (indolent) variant. The non-invasive variants inclu... | {
"pile_set_name": "PubMed Central"
} |
Introducción {#sec0005}
============
En 1997 la Organización Mundial de la Salud (OMS) declaró la obesidad como una epidemia global y propuso un conjunto de medidas para prevenirla[@bib0005]. Se ha relacionado la obesidad en la infancia y en la adolescencia con problemas de salud como el aumento del colesterol y de lo... | {
"pile_set_name": "PubMed Central"
} |
Smith LK, Dickens J, Bender Atik R, Bevan C, Fisher J, Hinton L. Parents' experiences of care following the loss of a baby at the margins between miscarriage, stillbirth and neonatal death: a UK qualitative study. BJOG 2020;127:868--874.31976622
**Linked article** This article is commented on by RJ Lee and PJ Steer, p... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#s0}
============
The ultimate goal for many microbial ecologists is to fully characterize niches of microbial organisms and understand interactions among taxa. An understanding of how microbial communities are affected by environmental conditions might yield insights into microbial interactions and thei... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Ketoprofen (KP; (RS)-2-(3-benzoylphenyl)-propionic acid) is nonsteroidal anti-inflammatory drug predominantly used in treatment of rheumatoid arthritis and osteoarthritis. It acts as an anti-inflammatory agent by reversible inhibition of cyclooxygenase 1 and 2 enzymes leading to... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Marine macroalgae are complex multicellular photosynthetic organisms, evolutionary distinct from land plants, and constitute a large primary biomass in coastal ecosystems. Polysaccharides constitute about half of the algal tissues and can be found either as carbon storage or cell wall compoun... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Accumulating evidences suggested that general anesthetics, including intravenous anesthetics, inhalation anesthetics \[[@B1]\], and opioids \[[@B2]\], could affect cancer cell growth and impact patients\' prognosis. Propofol (2,6-disopropylphenol), commonly dubbed as "milk of an... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
In combination with the anti-viral cytokine interferon (IFN)-α, Ribavirin is used to treat chronic Hepatitis C Virus (HCV) infection. Ribavirin lowers serum alanine aminotransferase levels of HCV infected patients [@pone.0027866-Reichard1], reduces HCV RNA levels [@pone.0027866-Bodenhei... | {
"pile_set_name": "PubMed Central"
} |
{#sp1 .534}
{#sp2 .535}
{#sp3 .536}
{#sp4 .537}
| {
"pile_set_name": "PubMed Central"
} |
Introduction
============
MicroRNAs (miRNAs/miRs) are a class of short endogenous non-coding RNAs that suppress gene expression by either degrading mRNA or repressing mRNA translation through complementary binding to their specific target mRNAs in the 3′-untranslated region ([@b1-ol-0-0-8045],[@b2-ol-0-0-8045]). Matur... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The majority of infections due to *Klebsiella pneumoniae* in Western countries are due to "classic" *K. pneumoniae* strains
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Friedlander, in 1882, described an encapsula... | {
"pile_set_name": "PubMed Central"
} |
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