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1. Introduction {#sec1}
===============
The important recent achievement in Parkinson\'s disease (PD) research has been the identification of several causative and risk genes with their putative functions. Leucine-rich repeat kinase 2 (LRRK2) gene has been distinguishable from other known PD genes with a number of fun... | 1. introduction { # sec1 } = = = = = = = = = = = = = = = the important recent achievement in parkinson \ ' s disease ( pd ) research has been the identification of several causative trait risk genes with their putative functions. leucine - rich repeat kinase 2 ( lrrk2 ) gene has been distinguishable from other specific... | 1. Introduction {# sec1} = = = = = = = = = = = = = = = The important rfcegt achievement in Parkinson \ ' s disease (PD) research has been the identification of several causative and risk genes with their putative functions. Leucine - rich repeat kinase 2 (LRRK2) gene has been distinguishable from other known PD genes w... | 1. Introduction {#sec1} =============== The important recent achievement in disease research has been the of several causative and with their putative functions. Leucine-rich repeat kinase 2 (LRRK2) gene has distinguishable from other known PD with a number of functional and epidemiologic features. LRRK2 is a highly co... | 1. InTRodUctIOn {#sEC1}
===============
thE impORTant rEceNT achiEvEmenT IN pArkInsoN\'S diSeAsE (pd) RESEarCH hAS Been the IDEnTIFICaTIoN oF SeVEraL CAUsatIvE And risk geNes WITh thEir pUtaTIvE FUnCtIoNs. leuCINE-rICh RepEat kinase 2 (lRRk2) GEnE haS beeN diStiNGUIshAble FROm OThER KnOWn pd GENes WITH a nUmbeR of FuN... | 1. Introduction {#sec1} =============== The important recent achievementin Parkinson\'s disease(PD) research has been the identification of several causative and risk genes with their putative functions. Leucine-rich repeat kinase 2 (LRRK2)gene has been distinguishable from other known PDgenes witha number... | 1. Introduction {#sec1} =============== The important recent achievement _in_ Parkinson\'s _disease_ (PD) research has been the _identification_ of several causative _and_ _risk_ genes with their putative functions. _Leucine-rich_ _repeat_ kinase 2 _(LRRK2)_ gene has _been_ distinguishable from other _known_ PD _genes_... |
Background {#Sec1}
==========
Medical school is an emotional experience for students. The influence of emotion on cognition is well recognized. Emotions affect learning of complex skills and knowledge and transferring information into new scenarios \[[@CR1]\]. From the psychological and cognitive view it is believed t... | background { # sec1 } = = = = = = = = = = medical school is an emotional experience for students. the influence of emotion on cognition is well recognized. emotions affect learning of complex skills and knowledge and transferring information into new scenarios \ [ [ @ cr1 ] \ ]. from the psychological and cognitive vie... | Background {# Sec1} = = = = = = = = = = Medical school is an emotional experience for students. The influence of emotion on cognition is well recognized. Emotions affect learning of complex skills and knowledge and transferring information into new scenarios \ [[ @ CR1] \ ]. From the psychological and cognitive view it... | Background {#Sec1} ========== Medical school is an emotional experience for students. The influence of emotion on cognition is well recognized. Emotions learning of complex skills and knowledge and transferring information into new scenarios \[[@CR1]\]. From the psychological and cognitive view it is believed that nega... | baCKgrOUnd {#sec1}
==========
mEdiCAl SCHoOL iS An EMotIoNal EXpeRieNce fOr STUdenTs. The InfluEnCe OF EMotIoN On cOgNItIoN IS welL rECOgNizEd. eMOtIonS AFFECT lEARNiNG OF cOMPLEX skILls And KnoWlEDgE aNd TransFeRrinG InFormAtIon InTo New sCenARIOS \[[@CR1]\]. frOm thE pSYchoLogical anD cOgnItIVE View it is beLiEvED t... | Background {#Sec1} ========== Medicalschoolis an emotional experience for students. The influence of emotion on cognitionis well recognized.Emotions affect learning ofcomplex skills and knowledge and transferring information into new scenarios \[[@CR1]\]. From thepsychological and cognitive viewit is believed ... | Background {#Sec1} ========== Medical school is an emotional experience for students. The _influence_ of emotion _on_ _cognition_ _is_ well _recognized._ Emotions affect learning of complex skills and _knowledge_ _and_ _transferring_ information into _new_ scenarios \[[@CR1]\]. From the _psychological_ _and_ _cognitive... |
1. Introduction {#sec1-toxics-07-00005}
===============
Endocrine disruptor compounds (EDCs) are mostly synthetic molecules from industrial origin \[[@B1-toxics-07-00005],[@B2-toxics-07-00005],[@B3-toxics-07-00005]\] but are also some natural molecules \[[@B4-toxics-07-00005],[@B5-toxics-07-00005]\] that are present i... | 1. introduction { # sec1 - toxics - 07 - 00005 } = = = = = = = = = = = = = = = endocrine disruptor compounds ( edcs ) are mostly signaling molecules from industrial origin \ [ [ @ b1 - toxics - 07 - 00005 ], [ @ b2 - toxics - 07 - 00005 ], [ @ b3 - toxics - 07 - 00005 ] \ ] but are also some natural molecules \ [ [ @ b... | 1. Introduction {# sec1 - toxics - 07 - 00005} = = = = = = = = = = = = = = = Endocrine disruptor compounds (EDCs) are mostly synthetic molecules from industrial origin \ [[ @ B1 - toxics - 07 - 00005 ], [@ B2 - toxics - 07 - 00005 ], [@ B3 - toxics - 07 - 00005] \] but are also some natural molecules \ [[ @ B4 - toxics... | 1. {#sec1-toxics-07-00005} =============== disruptor compounds (EDCs) are mostly synthetic molecules from industrial origin \[[@B1-toxics-07-00005],[@B2-toxics-07-00005],[@B3-toxics-07-00005]\] but are also some natural molecules \[[@B4-toxics-07-00005],[@B5-toxics-07-00005]\] that present in the environment and promot... | 1. iNTroducTiON {#sec1-toxics-07-00005}
===============
ENDOCrINE DISRupTOr CoMPoUNDS (eDCs) ArE MoSTLY SYNThETiC MoleculEs fROm INDUStrial oRigin \[[@b1-Toxics-07-00005],[@B2-TOxiCS-07-00005],[@B3-TOXicS-07-00005]\] BUt aRe ALSo Some naturAl moLEcUles \[[@B4-toxics-07-00005],[@b5-tOxicS-07-00005]\] thAT are preSENt i... | 1. Introduction {#sec1-toxics-07-00005}=============== Endocrine disruptorcompounds (EDCs) are mostly synthetic molecules from industrial origin \[[@B1-toxics-07-00005],[@B2-toxics-07-00005],[@B3-toxics-07-00005]\] but are also some natural molecules \[[@B4-toxics-07-00005],[@B5-toxics-07-00005]\] that arepre... | 1. Introduction _{#sec1-toxics-07-00005}_ =============== Endocrine disruptor compounds _(EDCs)_ are _mostly_ synthetic _molecules_ from industrial _origin_ _\[[@B1-toxics-07-00005],[@B2-toxics-07-00005],[@B3-toxics-07-00005]\]_ but are also some _natural_ molecules _\[[@B4-toxics-07-00005],[@B5-toxics-07-00005]\]_ _th... |
Background {#Sec1}
==========
Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused by hantaviruses. Each hantavirus tends to be specific to a different rodent or insectivore host \[[@CR1], [@CR2]\]. Two dominant hantaviruses, Seoul virus (SEOV) and Hantaan virus (HTNV), carried by *Rattus norv... | background { # sec1 } = = = = = = = = = = hemorrhagic fever with renal syndrome ( hfrs ) is a rodent - borne disease caused by hantaviruses. each hantavirus tends to be specific to a different rodent or insectivore host \ [ [ @ cr1 ], [ @ cr2 ] \ ]. two dominant hantaviruses, seoul virus ( seov ) and hantaan virus ( ht... | Background {# Sec1} = = = = = = = = = = Hemorrhagic fever with renal syndrome (HFRS) is a rodent - borne disease caused by hantaviruses. Each hantavirus tends to be specific to a different rodent or insectivore host \ [[ @ CR1 ], [@ CR2] \ ]. Two dominant hantaviruses, Seoul virus (SEOV) and Hantaan virus (HTNV ), xsrr... | Background {#Sec1} ========== Hemorrhagic with renal syndrome (HFRS) rodent-borne disease caused by hantaviruses. Each hantavirus tends to be specific to a different rodent or insectivore host \[[@CR1], [@CR2]\]. Two dominant hantaviruses, Seoul virus (SEOV) and Hantaan virus (HTNV), carried by *Rattus and *Apodemus re... | BaCKGround {#seC1}
==========
HemoRrhAGIc fEVer wiTh rENAL synDromE (HFrs) IS a rodeNT-BoRnE dIsease CauSEd BY HAntAviRuSeS. eACh HAntaVIRus tENds tO BE SpECifiC tO a DifFERENT rOdENT oR INSectIvORE hOST \[[@cr1], [@Cr2]\]. twO dominaNT HaNtAviRUSES, seoUl VirUS (SEoV) And HantAaN Virus (htnv), CarRied BY *RaTtus norv... | Background {#Sec1}==========Hemorrhagic feverwith renal syndrome (HFRS) is a rodent-borne diseasecaused by hantaviruses. Each hantavirus tendsto be specific to a different rodentor insectivore host\[[@CR1], [@CR2]\]. Two dominant hantaviruses, Seoulvirus (SEOV) and Hantaan virus (HTNV), carried by *Rattus norveg... | Background {#Sec1} ========== _Hemorrhagic_ fever with renal syndrome (HFRS) is a rodent-borne disease caused by hantaviruses. _Each_ hantavirus tends _to_ be specific to a different _rodent_ or insectivore host _\[[@CR1],_ [@CR2]\]. Two dominant hantaviruses, Seoul virus (SEOV) and Hantaan virus (HTNV), carried by *Ra... |
Introduction {#sec1-1}
============
Tuberculosis (TB) is a common infectious disease in the developing countries. Antitubercular therapy with the first line drugs is very effective and well-tolerated with only few major adverse reactions. Cutaneous adverse drug reactions (CADR) with antitubercular treatment (ATT) can ... | introduction { # sec1 - 1 } = = = = = = = = = = = = tuberculosis ( tb ) is a common skin disease in the developing countries. antitubercular therapy with the first line drugs is very effective and well - tolerated with only few major adverse reactions. cutaneous adverse drug reactions ( cadr ) with antitubercular treat... | Introduction {# sec1 - 1} = = = = = = = = = = = = Tuberculosis (TB) is a common infectious disease in the developing countries. Antitubercular therapy with the first line drugs is very effective and well - tolerated with only few major adverse reactions. Cutaneous adverse drug reactions (CADR) with antitubercular treat... | Introduction {#sec1-1} ============ Tuberculosis (TB) is a common infectious disease in the developing countries. Antitubercular therapy with the first drugs is very effective and well-tolerated with only few major adverse reactions. Cutaneous adverse reactions (CADR) with antitubercular treatment (ATT) can make furthe... | InTRODUCtion {#SEC1-1}
============
TUBERcuLOsIs (TB) Is A CommoN infecTIoUS dISeASE iN the DeVELOping coUNTRies. aNTitUbERcular THERApY wiTh thE FIrsT liNe DRuGs Is VEry eFfective and WEll-TOLeRatEd with only FeW MAJoR aDvERse reaCtiONS. cUtANEouS ADvErse DRug ReActioNS (cADr) WIth anTitubERCULar TreatmEnt (ATT) CaN ... | Introduction{#sec1-1} ============Tuberculosis (TB) isa common infectious disease in the developingcountries. Antitubercular therapy with the first line drugs is very effective and well-tolerated with only few majoradverse reactions. Cutaneous adverse drug reactions (CADR) with antitubercular treatment... | Introduction {#sec1-1} _============_ Tuberculosis (TB) is a _common_ _infectious_ disease _in_ the developing countries. Antitubercular therapy with the first line drugs is _very_ effective _and_ well-tolerated with _only_ few major adverse reactions. Cutaneous adverse drug reactions (CADR) with _antitubercular_ treat... |
1. Introduction {#sec1-micromachines-10-00324}
===============
Tactile sensors, most commonly referred to as strain and pressure sensors, can collect mechanical property data from the human body and the local environment, and then provide valuable insights into the human health status or artificial intelligence system... | 1. introduction { # sec1 - micromachines - 10 - 00324 } = = = = = = = = = = = = = = = tactile sensors, most commonly referred to as strain and pressure sensors, can collect mechanical property data from the human body and the local environment, and then provide valuable insights into the human health status or artifici... | 1. Introduction {# sec1 - micromachines - 10 - 00324} = = = = = = = = = = = = = = = Tactile sensors, most commonly referred to as strain and pressure sensors, can collect mechanical property data from the human body and the local environment, and then provide valuable insights into the human health status or artificial... | 1. Introduction =============== Tactile sensors, commonly referred to as strain and pressure sensors, can collect mechanical data from the human body and the environment, and then valuable insights into the human health status or artificial intelligence systems \[[@B1-micromachines-10-00324],[@B2-micromachines-10-00324... | 1. INtrOdUctIoN {#SeC1-MIcROMAchINES-10-00324}
===============
TacTiLE sensOrS, MOSt COMMoNly REFErred TO As STRAin AnD pReSSuRe seNsoRs, Can colLEct MechaniCal pRopErtY DAtA fRom tHE hUmAN BoDy ANd THe locAL eNvirOnment, and THEn PRoVide ValuaBle inSiGHTs Into THe human heALtH statuS Or artIFiCiaL inTELLiGENce SYsTEM... | 1. Introduction {#sec1-micromachines-10-00324} =============== Tactile sensors, most commonly referred to as strain and pressuresensors, can collect mechanical property datafrom the human body and the local environment,and then provide valuable insights into the humanhealth status or artificial inte... | 1. Introduction _{#sec1-micromachines-10-00324}_ =============== Tactile sensors, most commonly referred to as _strain_ and _pressure_ sensors, can collect mechanical property data from the human _body_ _and_ _the_ local environment, and then provide valuable insights _into_ the human health status or artificial intell... |
C-type natriuretic peptide (CNP), the third discovered member of the natriuretic peptide (NP) family, received its name because it shares a common amino acid core structure with the previously isolated cardiac hormones atrial and B-type NPs (ANP and BNP) (reviewed in ([@CIT0001])). However, human and murine genetic stu... | c - type natriuretic peptide ( cnp ), the third discovered member of the natriuretic hormone ( np ) family, received its name because it shares a common amino acid core structure with the previously isolated cardiac hormones atrial and n - type nps ( anp and bnp ) ( reviewed in ( [ @ cit0001 ] ) ). however, human and m... | C - type natriuretic peptide (CNP ), the third discovered member of the natriuretic peptide (NP) family, received its name because it shares a common amino acid core structure with the previously isolated cardiac hormones atrial and B - type NPs (ANP and BNP) (reviewed in ([ @ CIT0001] ) ). However, human and murine ge... | C-type peptide (CNP), the third discovered member of the natriuretic peptide (NP) family, received its name because it shares a common amino acid core structure with the isolated cardiac hormones atrial and B-type NPs (ANP and BNP) (reviewed in ([@CIT0001])). However, human and murine genetic later revealed that CNP's ... | c-type NatrIUREtIC peptIde (CNP), tHe thIRD DISCoVERED mEMbEr oF tHE NATRIURETiC pepTiDE (Np) fAmIly, rECeived Its nAme bECAuse it sHARES A COMmON AMiNo Acid cORE sTruCtuRe wiTH tHE PREVIoUsLY ISolaTed CardiAC horMOnEs aTRIal And B-typE NpS (anP aND bnP) (reVieWEd in ([@ciT0001])). HoWeVEr, HUmaN And mUriNe gENEtic STU... | C-type natriuretic peptide(CNP), the third discovered member of the natriuretic peptide (NP) family, received its name because itshares a common amino acidcorestructure with the previously isolated cardiac hormonesatrial and B-type NPs (ANP and BNP) (reviewedin([@CIT0001])). However, human and m... | C-type natriuretic peptide (CNP), _the_ _third_ discovered member of _the_ natriuretic peptide (NP) family, received its name _because_ it shares a _common_ amino acid _core_ structure with the previously isolated cardiac hormones atrial and _B-type_ NPs _(ANP_ and BNP) (reviewed in ([@CIT0001])). However, human and mu... |
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{#sp3 .340}
{#sp4 .341}
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| ! [ ] ( sp - 0047 ) { # sp1. 338 }! [ ] ( bromley - 345 ) { # 336. 339 }! [ ] ( indmedgaz74499 - 334 ) { # 337. 340 }! [ ] ( indmedgaz74499 - 0050 ) { # sp4. 5 }! [ ] ( indmedgaz74499 - 33 ) { # sp5. 341 }! [ ] ( indmedgaz74499 - 345 ) { # sp6. 343 } | ! [] (indmedgSs74499 - 00r^) {# sp1. 338 }! [] (indmedgzz74409 - 00%u) {# sp2. 339 }! [] (indmedgAa74499 - 00EI) {# sp3. 340 }! [] (indmedgaz74499 - 00R0) {# sp4. 341 }! [] (ihdmedtaz74499 - 00Tq) {# sp5. 342 }! [] (&ndmedgaz7$499 - 0052) {# sp6. 343 } | {#sp1 .338} {#sp2 {#sp3 .340} {#sp4 .341} {#sp5 .342} {#sp6 .343} | {#SP1 .338}
{#sp2 .339}
{#Sp3 .340}
{#sp4 .341}
{#sp5 .342}
{#sp6 .343}
| {#sp1 .338} {#sp2 .339} {#sp3 .340} {#sp4 .341} {#sp5 .342} {#sp6.343} | {#sp1 .338} {#sp2 .339} {#sp3 _.340}_ {#sp4 .341} {#sp5 .342} {#sp6 .343} |
1. Introduction {#sec0005}
===============
In space, microgravity affects the central circulation in humans and induces a number of adaptive changes within the cardiovascular system. Previous investigations showed that the baroreflex sensitivity fluctuates along with altered blood volume distribution \[[@bib0005], [@b... | 1. introduction { # sec0005 } = = = = = = = = = = = = = = = in space, microgravity affects the central circulation in humans and induces a number of adaptive changes within the cardiovascular system. previous investigations showed that the baroreflex sensitivity fluctuates along with altered blood volume distribution \... | 1. Introduction {# sec0005} = = = = = = = = = = = = = = = In space, microgravity affects the central circulation in humans and induces a number of adaptive changes within the cardiovascular system. Previous investigations showed that the baroreflex sensitivity fluctuates along with altered blood volume distribution \ [... | 1. Introduction {#sec0005} =============== In space, microgravity affects the central circulation in humans and induces a number of changes within the cardiovascular investigations showed that baroreflex sensitivity fluctuates along with altered blood distribution \[[@bib0005], [@bib0010], [@bib0015]\], which affects n... | 1. InTrODucTIon {#sec0005}
===============
in SPAcE, mICRoGrAVity afFectS tHe CENTRaL ciRculaTIon IN humAns and INdUCeS A NuMBeR Of ADapTIVE cHaNgEs wiThiN THE cARDIOVAScULAR sySTEm. pREVioUs InVesTIgATionS SHOWED tHAT ThE bArOReFLex seNSitIVity FLucTuaTES ALOng WITh AlTEReD BLOOd vOLuME DIsTRIbUTiOn \[[@biB0005], [@b... | 1. Introduction {#sec0005} ===============Inspace, microgravity affects the central circulation in humans and induces a number of adaptivechanges within the cardiovascularsystem. Previousinvestigations showed that thebaroreflex sensitivity fluctuates alongwith altered blood volume distribution \[[@bib... | 1. Introduction {#sec0005} =============== In space, _microgravity_ affects the central circulation in humans and induces a number of adaptive changes within the cardiovascular system. Previous investigations showed that the baroreflex sensitivity fluctuates along with _altered_ _blood_ volume _distribution_ \[[@bib000... |
Introduction {#s1}
============
Plant cell walls are a terrifically important source of raw material for food, fuel, and industrially chemicals ([@B8]). In addition, they are responsible for not only conferring a definitive shape to the cell and enabling overall growth, but it also provides material transportation and... | introduction { # − } = = = = = = = = = = = = plant cell walls are a terrifically important source of raw material for food, fuel, and industrially chemicals ( [ @ b8 ] ). in addition, they are responsible for not only conferring a definitive shape to their cell and enabling overall growth, but it also provides material... | Introduction {# s1} = = = = = = = = = = = = Plant cell walls are a terrifically important source of raw material for food, fuel, and industrially chemicals ([ @ B8] ). In addition, they are responsible for not only conferring a definitive shape to the cell and enabling overall growth, but it also provides material tran... | Introduction {#s1} Plant cell walls are a terrifically important source of raw material for food, fuel, industrially chemicals In addition, they are responsible for not only conferring a definitive the and enabling growth, but it also provides material transportation and protection of the cells\' inner contents. Plant ... | inTroDuCtiON {#s1}
============
plant CELl WALls aRe A teRRIFicALlY iMPOrtANT soURCe OF raw MAtERiAl FOR FOOD, FUEL, ANd iNDuStriALly CHEMicALS ([@b8]). IN aDdiTIOn, they Are reSpONsiBlE fOR noT oNLY CoNfERRING A dEFinItIvE SHape TO THe cElL aND eNABlInG OVeraLl growtH, buT it ALSo PrOVidES maTErial tRanSPORtATioN aNd... | Introduction{#s1} ============ Plantcell walls are a terrifically importantsourceof raw material forfood, fuel, andindustriallychemicals ([@B8]). Inaddition, they are responsible for not only conferring a definitive shape to the cell and enabling overall growth,but it also providesmaterial transportat... | Introduction {#s1} ============ Plant _cell_ walls are a terrifically important source of raw material for _food,_ fuel, and industrially chemicals _([@B8])._ In _addition,_ they are _responsible_ for not only conferring a definitive shape to the cell and _enabling_ overall growth, _but_ it also provides material trans... |
Introduction {#Sec1}
============
Competition tends to select for large size of individual offspring, balanced by a relatively smaller total number of offspring^[@CR1]--[@CR8]^. The competitive advantage of large offspring size is generally thought to occur during dominance interactions, such as during interference co... | introduction { # sec1 } = = = = = = = = = = = = competition tends to select for large size of individual offspring, balanced by a relatively smaller total number of offspring ^ [ @ cr1 ] - - [ @ cr8 ] ^. the competitive advantage of large offspring size is generally thought to occur during dominance interactions, such ... | Introduction {# Sec1} = = = = = = = = = = = = Competition tends to select for large size of individual offspring, balanced by a relatively smaller total number of offspring ^ [@ CR1] - - [@ CR8] ^. The competitive advantage of large offspring size is generally thought to occur during dominance interactions, such as dur... | {#Sec1} ============ Competition tends to select for large size of individual offspring, balanced by a relatively smaller total number of offspring^[@CR1]--[@CR8]^. The competitive advantage of offspring size is thought to occur dominance interactions, such during interference competition, in which organisms defend a r... | IntroDUCtion {#sec1}
============
compeTiTioN TenDs To SelECT foR lArGE SIZe of IndIVIdual oFfSpRInG, BAlancEd BY A reLaTIvelY SmaLler TOTaL nUmbeR of OFfSpRINg^[@cR1]--[@CR8]^. The comPEtItIve aDvaNtAge Of LARgE ofFSpRIng SIzE is GeNeRAllY tHoughT to OcCUR dUriNG DOmiNAncE InTeRaCTions, SUch As DURinG inTerFerence CO... | Introduction {#Sec1} ============ Competition tends to select for large size of individual offspring, balanced by a relatively smaller totalnumber of offspring^[@CR1]--[@CR8]^. The competitive advantage oflarge offspring size is generallythought to occurduring dominance interactions, suchasduri... | Introduction _{#Sec1}_ ============ Competition tends _to_ select for _large_ size of individual offspring, balanced by a relatively smaller total number _of_ offspring^[@CR1]--[@CR8]^. The _competitive_ advantage of large offspring size _is_ generally thought _to_ occur during _dominance_ interactions, such as _during... |
1. Introduction {#s0005}
===============
Tarlov cysts are perineural fluid-filled sacs that are usually found in the lumbosacral spine around the junction of peripheral nerve roots and the respective dorsal root ganglia. The cysts are extradural meningeal cysts with collections of cerebrospinal fluid (CSF) within the ... | 1. introduction { # s0005 } = = = = = = = = = = = = = = = tarlov cysts are perineural fluid - filled sacs that are usually found in the lumbosacral spine around the junction of axial nerve roots and the respective dorsal root ganglia. the cysts are mainly meningeal cysts with collections of cerebrospinal fluid ( csf ) ... | 1. Introduction {# s0005} = = = = = = = = = = = = = = = Tarlov cysts are perineural fluid - filled sacs that are usually found in the lumbosacral spine around the junction of peripheral nerve roots and the respective dorsal root ganglia. The cysts are extradural meningeal cysts with collections of cerebrospinal fluid (... | 1. Introduction {#s0005} =============== Tarlov cysts fluid-filled sacs that are usually found in the lumbosacral spine around peripheral nerve and respective dorsal root ganglia. The cysts are extradural meningeal cysts with collections of cerebrospinal fluid (CSF) within the nerve root sheath \[[@bb0005]\]. Tarlov ar... | 1. INtrodUCTIoN {#s0005}
===============
tARLOV cystS aRE peRiNeURal fluId-FiLlEd sAcs tHat aRe uSUALly FOuND in tHE LumbosacrAL spINE AroUnD THe juncTiOn oF PErIpheRal NervE RoOts and ThE RespecTIve DORSal RoOT gAngLIa. tHe cYStS aRe extRaDUraL meNiNgeAL CysTS wIth COLlEcTiONs Of cEREbRoSPINaL fLUid (Csf) within THE ... | 1. Introduction {#s0005} ===============Tarlovcysts are perineural fluid-filled sacs that are usually found in the lumbosacral spine around the junction of peripheral nerve roots and therespective dorsal root ganglia. The cysts are extradural meningeal cysts withcollections of cerebrospin... | 1. Introduction {#s0005} =============== Tarlov cysts are perineural fluid-filled sacs _that_ are _usually_ found _in_ the lumbosacral _spine_ around _the_ junction of peripheral nerve roots and _the_ respective dorsal root ganglia. The cysts are extradural meningeal _cysts_ _with_ collections of cerebrospinal _fluid_ ... |
Human airway epithelia function in barrier formation, defense against pathogens, and mucociliary clearance ([@b11-ehp-119-784]). They represent the first barrier against airborne environmental pollutants, and they coordinate recruitment of pivotal inflammatory cells in several pathologies, including chronic obstructive... | human airway epithelia function in barrier formation, defense against pathogens, and mucociliary clearance ( [ @ b11 - ehp - 119 - 784 ] ). they represent the first barrier against airborne environmental pollutants, and they coordinate recruitment of pivotal inflammatory cells in several pathologies, including chronic ... | Human airway epithelia function in barrier formation, defense against pathogens, and mucociliary clearance ([ @ b11 - ehp - 119 - 784] ). They represent the first barrier against airborne environmental pollutants, and they coordinate recruitment of pivotal inflammatory cells in several pathologies, including chronic ob... | Human airway function in formation, defense against pathogens, and mucociliary clearance ([@b11-ehp-119-784]). They represent the first barrier against airborne environmental pollutants, and they coordinate recruitment of pivotal inflammatory cells in several pathologies, including chronic obstructive pulmonary disease... | huMan AiRWAY EpiTheLIa FUNCtion in bArRiER fOrmaTIOn, dEfEnse aGAINST pATHOGeNS, And MUCOCIliaRY cLEArance ([@B11-EHp-119-784]). tHeY rePrESenT The fIrsT BArriEr AgAiNST aiRboRnE enVIRoNMENTAl pOlluTaNTs, aND tHeY COORdInATe reCRuiTMENT of PiVOTAL INflAmmatORy CeLlS IN SevERaL PAtHoLOGIES, iNcLUDing cHrONic obstrUCTiVE... | Human airway epithelia function in barrier formation, defense against pathogens, and mucociliary clearance ([@b11-ehp-119-784]). They represent the first barrier against airborne environmental pollutants, and they coordinaterecruitment of pivotal inflammatory cells in several pathologies, including c... | _Human_ airway epithelia function in barrier formation, _defense_ against pathogens, and mucociliary clearance ([@b11-ehp-119-784]). They represent the _first_ barrier against airborne environmental _pollutants,_ _and_ they coordinate _recruitment_ _of_ pivotal inflammatory cells in several _pathologies,_ including chr... |
1. Introduction {#sec1-ijerph-17-01164}
===============
Diabetes represents a clustering of heterogeneous risk factors that affects all aspects of quality of life due to the lifetime demands of diabetes care \[[@B1-ijerph-17-01164]\]. Health-related quality of life (HRQoL) refers to a multi-dimensional concept of qual... | 1. introduction { # sec1 - ijerph - 17 - 01164 } = = = = = = = = = = = = = = = diabetes represents a clustering of heterogeneous risk factors that affects all aspects of quality of life due to the lifetime demands of diabetes care \ [ [ @ b1 - ijerph - 17 - 01164 ] \ ]. health - related fitness of life ( hrqol ) refers... | 1. Introduction {# sec1 - ijerph - 17 - 01164} = = = = = = = = = = = = = = = Diabetes represents a clustering of heterogeneous risk factors that affects all aspects of quality of life due to the lifetime demands of diabetes care \ [[ @ B1 - ijerph - 17 - 01164] \ ]. Health - related quality of life (HRQoL) refers to a ... | 1. Introduction {#sec1-ijerph-17-01164} =============== Diabetes represents a clustering of heterogeneous risk factors that affects all aspects of quality of life due to the lifetime demands of diabetes care \[[@B1-ijerph-17-01164]\]. Health-related quality of life refers to concept of quality life, can be affected by ... | 1. iNTroductIOn {#SEC1-IjerPh-17-01164}
===============
DIabETeS REpreseNts A cLuStErInG OF heTErOgenEOuS RIsK FactorS tHAt AFfeCtS AlL ASPEcts oF QuAlity OF LIfE DUE tO THe LifeTImE deMAndS OF DIABeTes CARE \[[@b1-ijeRPH-17-01164]\]. HealTH-relATeD quaLItY OF lIfE (HrqoL) REfErS to a mulTi-dImEnsiONal CoNcEpt oF QUAL... | 1. Introduction{#sec1-ijerph-17-01164} =============== Diabetes represents a clustering of heterogeneous risk factors that affects all aspectsof quality of life due to the lifetime demands of diabetes care \[[@B1-ijerph-17-01164]\]. Health-related quality of life (HRQoL) refers to a multi-dimensional concep... | 1. Introduction {#sec1-ijerph-17-01164} =============== _Diabetes_ represents a _clustering_ of heterogeneous _risk_ factors that affects _all_ aspects of quality of life _due_ to the lifetime demands of diabetes _care_ \[[@B1-ijerph-17-01164]\]. Health-related quality _of_ life (HRQoL) refers to _a_ multi-dimensional ... |
Introduction {#Sec1}
============
Major depressive disorder (MDD) is a disease affecting around 16% of people over the age of 13 in the US^[@CR1]^. This prevalent mood disorder greatly impacts a patient's quality of life and is the leading cause of disability around the world^[@CR2]^. Experiencing stressful events thr... | introduction { # sec1 } = = = = = = = = = = = = major depressive disorder ( mdd ) is a disease affecting around 16 % of people over the age of 60 in the us ^ [ @ cr1 ] ^. this prevalent mood disorder greatly impacts a patient ' s quality of life and is the leading cause of disability around the world ^ [ @ cr2 ] ^. pre... | Introduction {# Sec1} = = = = = = = = = = = = Major depressive disorder (MDD) is a disease affecting around 16% of people over the age of 13 in the US ^ [@ CR1] ^. This prevalent mood disorder greatly impacts a patient ' s quality of life and is the leading cause of disability around the world ^ [@ CR2] ^. Experiencing... | Introduction {#Sec1} ============ Major depressive disorder (MDD) is a disease affecting around 16% of people over the age of 13 in the US^[@CR1]^. This prevalent mood disorder greatly impacts a patient's quality of life is the leading cause of disability around the world^[@CR2]^. Experiencing stressful events througho... | IntRODuction {#seC1}
============
MaJOr DEpresSiVe DISoRDer (mDd) is A DISEAsE AffECtiNg Around 16% oF PEOplE ovER The aGe Of 13 In ThE US^[@cr1]^. tHiS prevalenT MooD diSoRDeR GreATLY IMpAcTS A paTienT'S quAlITY of LIfE AND iS THE leadInG CAUsE of diSABIlItY ArouNd tHe worLd^[@cR2]^. ExPerieNCING stReSSFUL eVenTS THR... | Introduction{#Sec1} ============ Major depressive disorder (MDD) is a disease affecting around 16% of people over the ageof 13in the US^[@CR1]^. This prevalent mood disorder greatly impactsa patient'squalityof life and is the leading cause of disability around theworld^[@CR2]^. Experiencing stressful events... | Introduction {#Sec1} ============ _Major_ depressive disorder (MDD) is _a_ disease _affecting_ around _16%_ _of_ _people_ over _the_ age of 13 in the US^[@CR1]^. This prevalent _mood_ disorder greatly impacts a patient's quality _of_ life _and_ is the leading cause of disability _around_ the world^[@CR2]^. Experiencing... |
1. Introduction {#sec1-ijerph-17-01067}
===============
Nasolacrimal duct obstruction (NLDO) is the most common cause of childhood epiphora \[[@B1-ijerph-17-01067]\]. Failed canalisation of the distal nasolacrimal duct, associated with a membranous obstruction at the level of Hasner's valve, is the main cause of conge... | 1. introduction { # sec1 - ijerph - 17 - 01067 } = = = = = = = = = = = = = = = nasolacrimal artery obstruction ( nldo ) is the most common cause of childhood epiphora \ [ [ @ b1 - ijerph - 17 - 01067 ] \ ]. failed canalisation of the distal nasolacrimal duct, associated with a membranous obstruction at the level of has... | 1. Introduction {# sec1 - ijerph - 17 - 01067} = = = = = = = = = = = = = = = Nasolacrimal duct obstruction (NLDO) is the most common cause of childhood epiphora \ [[ @ B1 - ijerph - 17 - 01067] \ ]. Failed canalisation of the distal nasolacrimal duct, associated with a membranous obstruction at the level of Hasner ' s ... | 1. Introduction {#sec1-ijerph-17-01067} =============== Nasolacrimal duct obstruction (NLDO) is the most common cause of childhood epiphora \[[@B1-ijerph-17-01067]\]. Failed canalisation of the distal associated a membranous obstruction the level of Hasner's valve, the main of congenital NLDO; acquired causes of NLDO i... | 1. inTRoDucTIoN {#SEC1-IjERpH-17-01067}
===============
NASOlACRimAl DUct OBsTRuctION (nLdo) iS tHe MoSt cOMmoN cAuSE oF ChIldhoOD ePIPhORa \[[@B1-iJERPH-17-01067]\]. FAileD CanAlIsATIoN OF THe disTAL NAsoLacRimal duct, aSSOciaTED WiTh A mEMBRAnOus obSTRucTiOn At the lEvEl OF HaSnEr'S vALvE, IS The mAin Cause OF cONGE... | 1. Introduction {#sec1-ijerph-17-01067} ===============Nasolacrimal duct obstruction (NLDO) is the most common cause of childhood epiphora \[[@B1-ijerph-17-01067]\]. Failed canalisation of the distal nasolacrimal duct, associated with a membranous obstructionat the level ofHasner's valve, is the main caus... | _1._ Introduction {#sec1-ijerph-17-01067} =============== _Nasolacrimal_ duct _obstruction_ (NLDO) is the most _common_ cause of childhood _epiphora_ \[[@B1-ijerph-17-01067]\]. Failed _canalisation_ of the distal nasolacrimal duct, associated _with_ a membranous obstruction at _the_ level of Hasner's valve, _is_ the ma... |
Introduction {#sec1-1}
============
Chicken is the cheapest source of protein available for human consumption, but it cannot tolerate a wide range of climatic variations which affects the production and reproduction. Climate change and animal production always are complementary to each other and its effect on livestoc... | introduction { # sec1 - 1 } = = = = = = = = = = = = chicken is the cheapest source of protein intended for human consumption, but it cannot tolerate a wide range of climatic variations which affects the production and reproduction. climate change and animal production always are complementary to each other and its effe... | Introduction {# sec1 - 1} = = = = = = = = = = = = Chicken is the cheapest source of protein available for hjmaj consumption, but it cannot tolerate a wide range of climatic variations which affects the production and reproduction. Climate change and animal production always are complementary to each other and its effec... | Introduction {#sec1-1} ============ is the cheapest source of protein available for human consumption, but it cannot tolerate a wide range climatic variations which affects the production reproduction. Climate change and animal production always are complementary to each other its effect on livestock and poultry produc... | IntrOduCTion {#sec1-1}
============
chIckEn IS THe CHEaPEsT SOurCE of proTEIN AvaILablE FoR HUmaN cOnSuMPTiON, But It CANnot TOlERaTe A WiDE RanGe oF ClImATic vArIatIoNS WhIch affEcTS the PROdUctiOn and rEproDUCTiON. ClImATe cHANGE and ANImal pRoDUcTIon alWAys ARE ComplEMeNTarY to EACh OthEr aND iTs EFFecT ON LIVeSToc... | Introduction {#sec1-1} ============ Chicken is the cheapest source of protein available for human consumption, but it cannot tolerate a wide range of climatic variations which affects the productionand reproduction. Climate change andanimal production always are complementary to each other and its ef... | Introduction {#sec1-1} ============ _Chicken_ is the cheapest source of protein _available_ _for_ human consumption, _but_ it cannot tolerate a wide range of climatic _variations_ _which_ _affects_ the production and reproduction. Climate _change_ and animal production _always_ are complementary to each other and its e... |
1. Introduction {#sec1-sensors-15-26039}
===============
A variety of devices have been developed to extract energy from the environment through piezoelectric, electromagnetic and thermoelectric energy conversion \[[@B1-sensors-15-26039],[@B2-sensors-15-26039],[@B3-sensors-15-26039],[@B4-sensors-15-26039],[@B5-sensors... | 1. introduction { # sec1 - sensors - 15 - 26039 } = = = = = = = = = = = = = = = a variety of ways have been developed to extract energy from the environment through piezoelectric, electromagnetic and thermoelectric energy conversion \ [ [ @ b1 - sensors - instruments - 26039 ], [ @ b2 - sensors - 15 - 26039 ], [ @ b3 -... | 1. Introduction {# sec1 - sensors - 15 - 26039} = = = = = = = = = = = = = = = A variety of devices have been developed to extract energy from the environment through piezoelectric, electromagnetic and thermoelectric energy conversion \ [[ @ B1 - sensors - 15 - 26039 ], [@ B2 - sensors - 15 - 26039 ], [@ B3 - sensors - ... | 1. Introduction {#sec1-sensors-15-26039} =============== A variety of devices have been developed to extract energy from the environment through electromagnetic and thermoelectric \[[@B1-sensors-15-26039],[@B2-sensors-15-26039],[@B3-sensors-15-26039],[@B4-sensors-15-26039],[@B5-sensors-15-26039],[@B6-sensors-15-26039]\... | 1. INtrODUctioN {#SeC1-Sensors-15-26039}
===============
A VARiety OF DEvIcES Have Been DEVElOpEd to eXtRAcT enERgY from The eNViroNMenT tHROUgh PiEZOElEctric, elECtromaGNEtIC and TheRmOeLectric eNeRGY ConveRSIOn \[[@B1-SEnSORs-15-26039],[@B2-SENSors-15-26039],[@b3-sEnSOrS-15-26039],[@b4-SeNSORS-15-26039],[@b5-SeNSoRs... | 1. Introduction {#sec1-sensors-15-26039}=============== A variety of devices have been developed to extract energy from the environment through piezoelectric,electromagnetic and thermoelectric energy conversion \[[@B1-sensors-15-26039],[@B2-sensors-15-26039],[@B3-sensors-15-26039],[@B4-sensors-15-26039],[@B5-s... | _1._ _Introduction_ {#sec1-sensors-15-26039} _===============_ _A_ variety of _devices_ have been developed _to_ extract _energy_ from the _environment_ through piezoelectric, _electromagnetic_ and thermoelectric energy conversion \[[@B1-sensors-15-26039],[@B2-sensors-15-26039],[@B3-sensors-15-26039],[@B4-sensors-15-26... |
Background
==========
There is an increasing interest in studying genotype by environment interactions in terrestrial and aquatic organisms to clarify how different populations might have diverged to become adapted to local habitats, and to understand how populations may respond to human-induced selection. In marine f... | background = = = = = = = = = = there is an increasing interest in studying genotype by environment interactions in terrestrial and aquatic organisms to clarify how different populations might have diverged to become adapted to local habitats, and to understand how populations may respond to human - induced selection. i... | Background = = = = = = = = = = There is an increasing interest in studying genotype by environment interactions in terrestrial and aquatic organisms to clarify how different populations might have diverged to become adapted to local habitats, and to understand how populations may respond to human - induced selection. I... | ========== There is an increasing interest in studying genotype by environment interactions in terrestrial organisms to how different populations might have diverged to become adapted to local habitats, and to populations may respond to human-induced selection. In marine fishes the population structure is expected to w... | BAckgROuND
==========
tHerE IS an increASINg interESt IN stUDyING geNOTyPe By EnvIroNMeNt InTErAcTIonS in TErrEsTrial AND AQuATIc orgaNisms tO clariFy hOW diFfEReNt pOpUlATIONS MiGht Have diveRgED to bECome AdaPtEd To lOcal HAbiTaTS, AnD To UndeRSTANd HOw PoPulatIons mAY ReSPoNd TO HUMAn-iNDUCed seleCtIoN. in MARinE f... | Background ========== Thereis an increasing interestin studying genotype by environmentinteractions interrestrial andaquatic organisms to clarify how different populations might have diverged to become adaptedto local habitats, and to understand how populationsmay respond to human-induced selection. In marine fish... | _Background_ ========== There _is_ an increasing _interest_ in studying genotype by environment interactions in terrestrial and aquatic organisms to clarify how different populations might have diverged to _become_ adapted to local habitats, _and_ to understand how _populations_ may respond to human-induced selection. ... |
Introduction
============
Mussels of the genus *Mytilus* are widespread in both the Northern and Southern Hemispheres and are important components of coastal ecosystems ([@ref-79]; [@ref-68]; [@ref-51]). Mussels are a bivalve species of significant ecological and commercial value worldwide with annual production of 1.... | introduction = = = = = = = = = = = = mussels of the genus * mytilus * are widespread in both the northern and southern hemispheres and are important components of coastal ecosystems ( [ @ ref - 79 ] ; [ @ ref - 68 ] ; [ @ ref - 51 ] ). mussels are a bivalve species of significant ecological and commercial value worldwi... | Introduction = = = = = = = = = = = = Mussels of the genus * Mytilus * are widespread in both the Northern and Southern Hemispheres and are important components of coastal ecosystems ([ @ ref - 79 ]; [@ ref - 68 ]; [@ ref - 51] ). Mussels are a bivalve species of significant ecological and commercial value worldwide wit... | Introduction ============ Mussels the *Mytilus* are widespread in both the Northern and Southern Hemispheres and are important components of coastal ecosystems ([@ref-79]; [@ref-68]; [@ref-51]). Mussels are a bivalve species of significant ecological and commercial value worldwide with annual production of 1.2M tonnes ... | iNtrODUcTION
============
muSsEls oF THE genUS *mYTiLus* ARe wIDespREAd In BotH ThE nOrThern aNd SOuTHeRN hemISPHEreS ANd Are iMPOrtANT COMpOnEnTS Of coAstaL ecOSystEmS ([@rEF-79]; [@ReF-68]; [@ref-51]). mUSsels ArE A bIVAlvE SpeCiEs OF siGNIFICAnt eCOLogICal ANd CoMmerciaL vALuE woRLDWidE WitH anNuAl PRODucTIOn OF 1.... | Introduction ============ Mussels of the genus *Mytilus* are widespread in both the Northern and Southern Hemispheres and are important components of coastal ecosystems ([@ref-79]; [@ref-68]; [@ref-51]). Mussels are a bivalve species of significantecological andcommercial value worldwide with ... | _Introduction_ _============_ Mussels of the genus *Mytilus* _are_ widespread in both the Northern _and_ Southern Hemispheres and are important components _of_ coastal ecosystems ([@ref-79]; [@ref-68]; [@ref-51]). _Mussels_ are a bivalve species of significant _ecological_ _and_ _commercial_ value worldwide with annual... |
Introduction {#S1}
============
Background to Time Pressure {#S1.SS1}
---------------------------
Within modern society, perceived shortage of time is a frequently experienced aspect of daily life ([@B37]; [@B57]; [@B96]). Recognizing this, a range of academic disciplines have investigated time pressure. This breadth... | introduction { # s1 } = = = = = = = = = = = = background to time pressure { # s1. ss1 } - - - - - - - - - - - - - - - - - - - - - - - - - - - within modern society, perceived shortage of time is a frequently experienced aspect of daily life ( [ @ b37 ] ; [ @ b57 ] ; [ @ b96 ] ). recognizing this, a range of academic di... | Introduction {# S1} = = = = = = = = = = = = Background to Time Pressure {# S1. SS1} - - - - - - - - - - - - - - - - - - - - - - - - - - - Within modern society, perceived shortage of time is a frequently experienced aspect of daily life ([ @ B37 ]; [@ B57 ]; [@ B96] ). Recognizing this, a range of academic disciplines ... | Introduction {#S1} ============ Background to Time Pressure {#S1.SS1} --------------------------- Within modern society, perceived shortage of time is a frequently experienced aspect of daily life ([@B37]; [@B57]; [@B96]). Recognizing this, a range of academic disciplines have investigated time pressure. This breadth o... | INtrODuctiOn {#S1}
============
bAckgrouNd tO TIMe PrEsSUrE {#s1.sS1}
---------------------------
withiN moDeRn soCiety, PeRCEIVED SHORtaGE Of tIME iS a fReqUenTly ExpeRIENcED AspECt Of dAILY lifE ([@B37]; [@B57]; [@B96]). RECogNiZING tHis, A rANGe oF AcADeMIc discIPlinEs hAVE InVeStiGAtED TIme PRessUrE. ThIS bReaDtH... | Introduction {#S1} ============ Background to Time Pressure {#S1.SS1}--------------------------- Within modern society, perceived shortage of time is a frequently experienced aspectofdaily life ([@B37]; [@B57]; [@B96]).Recognizing this, a range of academicdisciplines have investigated time pressure. T... | Introduction _{#S1}_ ============ Background _to_ Time Pressure {#S1.SS1} --------------------------- Within modern society, _perceived_ shortage of time _is_ _a_ _frequently_ experienced aspect _of_ daily life ([@B37]; _[@B57];_ [@B96]). Recognizing this, a range of _academic_ disciplines _have_ _investigated_ time pr... |
[^1]: Academic Editor: Fray Marshall
| [ ^ 1 ] : academic editor : greg miller | [ ^ 1 ]: AcqdFmic Editor: F$Xy MaesUall | [^1]: Academic Editor: Fray | [^1]: ACadEmiC edITOr: FRay MArShALL
| [^1]: Academic Editor: FrayMarshall | [^1]: Academic Editor: Fray _Marshall_ |
The worldwide incidence of thyroid cancer is increasing ([@bib6]) with considerable international variation in incidence ([@bib28]). Thyroid cancer is an indolent disease often detected by ultrasound of incidentally discovered nodules and this may be due to diagnostic bias rooted in differential access to health care. ... | the worldwide incidence of thyroid cancer is increasing ( [ @ bib6 ] ) with considerable international variation in incidence ( [ @ bib28 ] ). thyroid cancer is an indolent disease often detected by ultrasound of incidentally discovered lesions and this may be due to diagnostic bias rooted in differential access to hea... | The worldwide incidence of thyroid cancer is increasing ([ @ bib6] ) with considerable international variation in incidence ([ @ bib28] ). Thyroid cancer is an indolent disease often detected by ultrasound of incidentally discovet$d nodules and this may be due to diagnostic bias rooted in differential access to health ... | The worldwide incidence of thyroid cancer is increasing ([@bib6]) with considerable international variation in incidence ([@bib28]). Thyroid cancer is indolent disease often by of incidentally discovered nodules and this may due to diagnostic bias in differential access to health care. ([@bib3]). However, other studies... | thE WORldwIde iNCiDEnCE oF ThyRoid CaNcER is incrEASInG ([@BIB6]) wItH CONSIDeRaBle inteRnaTiOnaL VariAtiOn IN iNcIDeNCe ([@bIB28]). thyROId canceR is An indoLeNt disEAsE oFten DeTeCtED bY uLTrAsOUND oF iNCidENtalLy dISCoVeREd nodULES and THiS MaY bE DUe To DiAGnOSTiC BIAS rOOTed in DIfFeRENTiAl AcCESS to hEaLTH CaRe. ... | Theworldwide incidence of thyroid canceris increasing ([@bib6]) with considerable international variation in incidence ([@bib28]). Thyroidcancer is an indolent disease oftendetected by ultrasound of incidentallydiscovered nodules and this may bedue to diagnostic bias rooted in differential access to ... | The _worldwide_ incidence of thyroid cancer _is_ increasing ([@bib6]) with considerable _international_ _variation_ in _incidence_ _([@bib28])._ Thyroid cancer is an indolent _disease_ often _detected_ by ultrasound of _incidentally_ discovered nodules _and_ this may be due _to_ diagnostic _bias_ _rooted_ in differenti... |
There is mounting evidence to support increased thrombo-embolic risk associated with coronavirus disease 2019 (COVID-19) infection. Here, we report a case of COVID-19 complicated by a right ventricular apical thrombus and aortic thrombi.
A 61-year-old woman with type 2 diabetes mellitus, hypertension, and hyperlipidae... | there is mounting evidence to support increased thrombo - embolic risk associated with coronavirus vaccine 2019 ( covid - 19 ) infection. here, we report a case of covid - 19 complicated by abnormal right ventricular apical thrombus and aortic thrombi. a 61 - year - old woman with type 2 diabetes mellitus, hypertension... | There is mounting evidence to support increased thrombo - embolic risk associated with coronaciruA disease 2019 (CODIS - 19) infection. Here, we report a case of COVID - 19 complicated by a right ventricular apical thrombus and aortic thrombi. A 61 - year - old woman with type 2 diabetes mellitus, hypertension, and hyp... | There is mounting evidence to support increased thrombo-embolic risk with coronavirus disease 2019 (COVID-19) infection. Here, we report a case of COVID-19 complicated by a right apical thrombus and aortic thrombi. 61-year-old woman type 2 diabetes mellitus, hypertension, and hyperlipidaemia presented to the emergency ... | THERe IS MoUNtING evIDEnCe To supPorT INCReaSeD THromBO-embOlIC rIsK AsSOciATed With CorOnAviRuS DIseASe 2019 (Covid-19) iNFECtioN. HeRe, we rEPOrt a cAsE of cOVid-19 cOmpLicATeD by a RiGhT veNTriCuLar aPIcaL ThROMbUS And AorTIC tHRomBi.
a 61-Year-OlD wOmAn with tyPe 2 DiABETeS MElLiTUs, HypertEnsion, AnD hYpeRLIpidAe... | There is mounting evidence to support increased thrombo-embolic risk associated with coronavirusdisease 2019(COVID-19)infection. Here, we report acase of COVID-19 complicated by a right ventricular apical thrombus and aortic thrombi.A 61-year-old woman with type 2 diabetes mellitus, hypertension, an... | There is mounting evidence to _support_ _increased_ thrombo-embolic risk associated with coronavirus _disease_ 2019 (COVID-19) infection. Here, we report a case of COVID-19 complicated by a _right_ ventricular apical _thrombus_ and aortic thrombi. A 61-year-old _woman_ _with_ type 2 diabetes _mellitus,_ _hypertension,_... |
Introduction
============
Mosquitoes including *Culex pipiens* are responsible for several serious diseases and able to transmit diseases agents infecting over 600 million people per year[@R1],[@R2]. *Culex pipiens pipiens* are known by their ecologic plasticity which explains their wide geographical distribution (tem... | introduction = = = = = = = = = = = = mosquitoes including * culex pipiens * are responsible for several serious diseases and able to transmit diseases agents infecting over 600 million people per year [ @ r1 ], [ @ r2 ]. * culex pipiens pipiens * are known by their ecologic plasticity which explains their wide worldwid... | Introduction = = = = = = = = = = = = Mosquitoes including * Culex pipiens * are responsible for several serious diseases and able to transmit diseases agents infecting over 600 million people per year [@ R1 ], [@ R2 ]. * Culex pipiens pipiens * are known by their ecologic plasticity which explains their wide geographic... | Introduction ============ Mosquitoes including *Culex pipiens* are responsible several serious diseases and able to transmit diseases agents infecting 600 million per year[@R1],[@R2]. *Culex pipiens pipiens* are known by their ecologic plasticity which explains their wide geographical distribution (temperate and region... | iNtroduction
============
mOsQuItOes INCludInG *CuLeX PipIeNS* aRe rEsPONSiBLE FOR SEVeRAl sERIous DiSEaseS anD abLe tO tRAnsmit DISEASeS agenTs INFeCTiNg OvER 600 MILLiON peOpLE pER yEAR[@R1],[@R2]. *CULex piPieNs piPiENs* Are knoWn By ThEiR ecOLogic plasticIty WHich eXpLAINs THeIr wiDE gEogRAPHiCAl distributIOn (Tem... | Introduction ============ Mosquitoes including *Culex pipiens*areresponsible forseveral serious diseases andable to transmit diseases agents infecting over 600 million peopleper year[@R1],[@R2].*Culex pipiens pipiens* are known by their ecologic plasticity which explains their wide geographical distribution (... | Introduction ============ Mosquitoes _including_ *Culex pipiens* are responsible for several serious diseases and able to _transmit_ diseases agents infecting over 600 million _people_ per _year[@R1],[@R2]._ *Culex pipiens pipiens* are known by their ecologic plasticity which explains their wide geographical _distribut... |
Objective
=========
Reduction of β-cell mass is increasingly recognized as one of the main contributing factors to the pathogenesis of type 2 diabetes. Chronic free fatty acid (FFA) exposure has been shown to induce endoplasmic reticulum (ER) stress that may contribute to promoting pancreatic β-cell apoptosis. In the ... | objective = = = = = = = = = reduction of β - cell mass is increasingly recognized as one of the main contributing factors underlying the pathogenesis of type 2 diabetes. chronic free fatty acid ( ffa ) exposure has been shown to induce spinal reticulum ( er ) stress that may contribute from bacterial pancreatic β - cel... | Objective = = = = = = = = = Reduction of β - cell mass is increasingly recognized as one of the main contributing factors to the pathogenesis of type 2 diabetes. Chronic free fatty acid (FFA) exposure has been shown to induce endoplasmic reticulum (ER) stress that may contribute to promoting pancreatic β - cell ALoptos... | Objective ========= Reduction of β-cell mass increasingly recognized one of main contributing factors the pathogenesis of 2 diabetes. Chronic free fatty acid (FFA) exposure has been shown to induce endoplasmic reticulum (ER) stress that may contribute to promoting pancreatic β-cell apoptosis. In the present study, we f... | OBJeCTive
=========
reDuCtiON OF Β-CelL MAss IS incReAsIngly ReCOGNIzEd As one Of THe MAin CONtRiBuTINg fACTorS TO THe PAThOgenESis OF TYpe 2 DIABetEs. chronic FRee fATtY aciD (FFA) EXposUre has bEEn SHOwn To INDUCE eNdOplAsMic RetICULum (eR) STRESs thAT maY COntrIbute tO PromOTiNG pAncreaTIc Β-CEll ApoPtoSiS. IN THe ... | Objective ========= Reduction of β-cell mass is increasingly recognized as one of the main contributing factors to the pathogenesis of type 2 diabetes. Chronic free fatty acid (FFA) exposurehas been shown to induce endoplasmic reticulum (ER) stress that maycontribute topromoting pancreatic β-cell apoptos... | Objective ========= Reduction _of_ β-cell mass is increasingly recognized as one of the main contributing factors to the _pathogenesis_ of type _2_ diabetes. _Chronic_ free _fatty_ acid (FFA) exposure has _been_ shown _to_ induce _endoplasmic_ reticulum (ER) stress that may contribute to promoting pancreatic β-cell _ap... |
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{.155} {.156} {.157} {.158} {.159} {.160} ![](envhper00385-0158.tif "scann... | {.155} _{.156} ![](envhper00385-0154.tif _"scanned-page"){.157}_ _![](envhper00385-0155.tif_ _"scanned-page"){.158}_ {.159} {.160} . However, many people living with this condition are not aware of their illness. In some cultures, it is also considered shameful to disclose one's... | introduction { # s1 } = = = = = = = = = = = = depression has become one amongst the leading causes of bullying worldwide. around 2015, 72. 5 % of depression patients lived with disability ( [ @ b1 ] ). however, many people living with this condition are not aware of their illness. in cultural cultures, it is also consi... | Introduction {# s1} = = = = = = = = = = = = Depression has become one of the leading causes of disability worldwide. In 2015, 7. 5% of depression patients lived with disability ([ @ B1] ). However, many people living with this condition are not aware of their illness. In slke cultures, it is also considered shameful to... | Introduction ============ Depression has become one of the leading causes of disability worldwide. In 2015, 7.5% of depression patients with disability ([@B1]). However, people living with this condition are not of their illness. In some cultures, it is also considered shameful to disclose one's mental health problems ... | intRODucTion {#s1}
============
DEpRESsion has BEcOME ONe of The lEaDIng causES oF disabiLITY WORLDWIDe. iN 2015, 7.5% of DEPReSSIoN pATIents LiveD WITH dISabiLity ([@B1]). HoWEver, maNy pEoPlE liViNG wIth thiS CoNdITiON aRE noT AWAre of THEir ilLNESs. In SOme CULtuRes, iT is aLSO cONSIdErEd ShamefuL To diSCLOSE ONe's... | Introduction {#s1} ============ Depression has become oneof the leading causes of disability worldwide.In 2015, 7.5% of depression patients lived with disability ([@B1]). However, many people living with this conditionare notaware of their illness. In somecultures, it isalso considered ... | _Introduction_ {#s1} ============ Depression has become one of _the_ leading causes of disability worldwide. In _2015,_ 7.5% of _depression_ patients lived with disability ([@B1]). However, _many_ people living with this condition _are_ not aware of their illness. In some cultures, it _is_ also _considered_ _shameful_ ... |
Introduction {#s1}
============
In the research field of drug addiction the mesolimbic dopaminergic system has always received great attention since the evidence that most of the substances of abuse are able to increase dopamine extracellular concentration in the Nucleus Accumbens (Di Chiara and Imperato, [@B13]). Onl... | introduction { # s1 } = = = = = = = = = = = = in the research field of drug addiction the mesolimbic dopaminergic system has always received great attention since the evidence that most of the substances of abuse are able to increase dopamine extracellular concentration towards this nucleus accumbens ( di chiara and im... | Introduction {# s1} = = = = = = = = = = = = In the research field of drug addiction the mesolimbic dopaminergic system has always received great attention since the evidence that most of the substances of abuse are able to increase dopamine extracellular concentration in the Nucleus Accumbens (Di Chiara and Imperato, [... | Introduction {#s1} ============ In the research field of addiction the mesolimbic dopaminergic system always received attention since the that most of the of abuse are able to increase dopamine extracellular concentration in Nucleus Accumbens (Di Chiara Imperato, [@B13]). recently it has been suggested that also dopami... | introDuctIOn {#s1}
============
iN THE REsEarcH FIelD oF DrUg adDIctIon THe mEsOliMBiC doPaminERGIc SysTEM Has alWays RecEiVED GREAt aTtENtIOn sinCE THE eViDenCE THaT Most of thE SUBSTAnCes Of aBusE aRE AblE tO InCreaSE doPAMInE extRACELlulAR cONcEntRATIOn in THE nUcLeus accuMbENS (DI CHIArA anD impeRato, [@b13]). ONL... | Introduction {#s1} ============ In the research field of drug addiction the mesolimbic dopaminergic system has always received great attentionsince the evidence that most of the substances of abuse are able to increase dopamine extracellular concentration inthe Nucleus Accumbens (Di Chiaraand Imperato,... | Introduction {#s1} ============ In _the_ _research_ _field_ of drug addiction the mesolimbic _dopaminergic_ system has always received great attention since the _evidence_ that most of the substances _of_ abuse _are_ able to _increase_ dopamine extracellular concentration _in_ _the_ Nucleus Accumbens (Di _Chiara_ and I... |
Background {#Sec1}
==========
Uterine artery embolization (UAE) for the treatment of uterine fibroids was first reported in 1995 \[[@CR1]\], and since then, many reports \[[@CR2]--[@CR15]\] have described the risks and benefits of UAE. Some reports \[[@CR12]--[@CR15]\] stated that preoperative UAE can help reduce blee... | background { # sec1 } = = = = = = = = = = uterine artery embolization ( uae ) for the treatment of uterine fibroids was first reported in 1995 \ [ [ @ cr1 ] \ ], and since 2007, many reports \ [ [ @ arab ] - - [ @ cr15 ] \ ] have described the risks and benefits of uae. some reports \ [ [ @ cr12 ] - - [ @ cr15 ] \ ] st... | Background {# Sec1} = = = = = = = = = = Uterine artery embolization (UAE) for the treatment of tt4rine fibroids was first reported in 1995 \ [[ @ CR1] \ ], and since then, many reports \ [[ @ CR2] - - [@ CR15] \] have described the risks and benefits of UAE. Some reports \ [[ @ CR12] - - [@ CR15] \] stated that preope... | Background {#Sec1} Uterine artery embolization (UAE) for the treatment of uterine fibroids was first reported in 1995 \[[@CR1]\], and since then, many reports \[[@CR2]--[@CR15]\] described the risks benefits of Some reports \[[@CR12]--[@CR15]\] stated that UAE can help reduce bleeding, and most reports indicated that i... | bACKGROuND {#SEc1}
==========
utERiNE aRtERY embOliZatIon (UAe) FOr The TReaTmENT oF UTERINe FIBRoIDs wAS FIrsT rEPoRTeD In 1995 \[[@CR1]\], anD sincE then, mAny repoRts \[[@cR2]--[@CR15]\] HAvE deSCrIBEd tHe rIsKS AnD BeNEfITs of uAE. some RepOrTS \[[@cR12]--[@CR15]\] STAteD THaT pReOPeratiVE uAE cAN heLP reduCE BlEe... | Background {#Sec1} ========== Uterineartery embolization (UAE)for the treatment of uterine fibroids was first reported in 1995 \[[@CR1]\], and since then, many reports \[[@CR2]--[@CR15]\] have describedthe risks and benefits of UAE. Some reports \[[@CR12]--[@CR15]\] stated that preoperative UAE can he... | Background {#Sec1} ========== Uterine artery embolization (UAE) _for_ the _treatment_ of uterine _fibroids_ was first reported in 1995 \[[@CR1]\], and since then, many reports \[[@CR2]--[@CR15]\] have described the _risks_ and benefits of UAE. Some reports \[[@CR12]--[@CR15]\] stated that preoperative UAE can help redu... |
Background {#Sec1}
==========
"Homeless" is a term generally conceptualised to refer to a group of individuals who have no regular access to a decent and conventional housing \[[@CR1]\]. However, the concept of decent housing is influenced by local cultural values, hence the difficulty to find a worldwide accepted def... | background { # sec1 } = = = = = = = = = = " homeless " is a term originally conceptualised to refer to a group of individuals who have no regular access to a decent and conventional housing \ [ [ @ cr1 ] \ ]. however, the concept of decent housing is influenced by local cultural barriers, hence the difficulty can find ... | Background {# Sec1} = = = = = = = = = = " Homeless " is a term generally conceptualised to refer to a group of individuals who have no regular access to a decent and conventional housing \ [[ @ CR1] \ ]. However, the concept of decent housing is influenced by local cultural values, hence the difficulty to find a worldw... | Background {#Sec1} ========== "Homeless" is a term generally to refer to a group individuals have no regular access to a decent and conventional housing \[[@CR1]\]. However, the of decent housing is influenced by local values, hence the difficulty to find a worldwide accepted definition \[[@CR2]\]. The homelessness con... | BAckGRoUnd {#Sec1}
==========
"homelEss" Is A TERm GENERaLLy cOncepTualISed to REFer to a grOUP OF inDIVIDUAls wHo HAVE NO ReGuLaR AccEss to A decENT And cOnventiONAl HoUsING \[[@CR1]\]. HOWeVeR, ThE COncEpt Of deCeNt HOusiNg IS INFLUencED by locAL culTurAl valueS, hencE tHe dIffICULtY To fiNd a WoRLdWide ACCEptEd def... | Background{#Sec1} ========== "Homeless" is a term generally conceptualised to refer to a groupofindividualswhohave no regularaccess to a decent and conventional housing \[[@CR1]\]. However, the conceptof decent housing is influenced by local cultural values, hence the difficulty to find a worldwide accept... | Background _{#Sec1}_ ========== _"Homeless"_ is _a_ _term_ _generally_ conceptualised to refer to a group of _individuals_ who _have_ no regular access to a decent and conventional housing _\[[@CR1]\]._ However, the concept _of_ decent housing is influenced by local cultural values, hence the difficulty to find _a_ wor... |
1. Introduction {#sec1-sensors-20-02641}
===============
In recent years, the field of indoor localization has increased in popularity due to both the increasing number of applications \[[@B1-sensors-20-02641]\] in domains such as surveillance \[[@B2-sensors-20-02641]\], navigation (both assistive and general purpose)... | 1. introduction { # sec1 - sensors - 20 - 02641 } = = = = = = = = = = = = = = = in recent years, the field of indoor localization has increased in popularity due to both the increasing number of applications \ [ [ @ b1 - sensors - 20 - 02641 ] \ ] in categories such as surveillance \ [ [ @ b2 - sensors - 20 - 02641 ] \... | 1. Introduction {# sec1 - sensors - 20 - 02641} = = = = = = = = = = = = = = = In recent years, the field of indoor localization has increased in popularity due to both the increasing number of applications \ [[ @ B1 - sensors - 20 - 02641] \] in domains such as surveillance \ [[ @ B2 - sensors - 20 - 02641] \ ], naviga... | 1. Introduction {#sec1-sensors-20-02641} =============== In recent years, the field of indoor localization has increased in popularity to both the increasing number applications \[[@B1-sensors-20-02641]\] domains such as surveillance \[[@B2-sensors-20-02641]\], navigation (both assistive and general purpose) robotics \... | 1. INTROduCTiOn {#sEc1-seNSoRS-20-02641}
===============
in RECeNT YeaRS, tHe fIELd OF INdoOr LocaLIzation haS InCrEaSED in pOpULaRiTy Due tO boTH The incReAsiNg NumbeR of AppLiCATiONs \[[@b1-SEnsORs-20-02641]\] iN DOmainS sucH as SURVeIlLaNCe \[[@b2-SEnsoRS-20-02641]\], NavigAtIOn (BoTH assIsTiVe and GenERAL purPOSe)... | 1. Introduction {#sec1-sensors-20-02641} =============== Inrecent years, the field of indoorlocalization has increased in popularity due to both the increasing number of applications \[[@B1-sensors-20-02641]\] in domainssuchas surveillance \[[@B2-sensors-20-02641]\], navigation (both assistive and gen... | 1. Introduction {#sec1-sensors-20-02641} =============== In recent years, the field of indoor localization has _increased_ in popularity _due_ _to_ both the increasing number of _applications_ \[[@B1-sensors-20-02641]\] in _domains_ _such_ as surveillance \[[@B2-sensors-20-02641]\], navigation (both assistive and gener... |
Background
==========
The intervertebral disc (IVD) lies between the vertebral bodies and links them together. The components of the disc are Nucleus pulposus (NP), Annulus fibrosus (AF) and the end-plates. Although the phenotype of IVD cells and the composition of the extracellular matrix (ECM) is still the subject o... | background = = = = = = = = = = the intervertebral disc ( ivd ) lies between the vertebral bodies and links them together. the components of the disc are nucleus pulposus ( np ), annulus fibrosus ( af ) and the end - plates. although the phenotype of ivd cells and the composition of the extracellular matrix ( ecm ) is s... | Background = = = = = = = = = = The intervertebral disc (IVD) lies between the vertebral bodies and links them together. The components of the disc are Nucleus pulposus (NP ), Annulus fibrosus (AF) and the end - plates. AlhhLugh the phenotype of IVD cells and the composition of the extracellular matrix (ECM) is still th... | Background ========== intervertebral disc lies between the vertebral bodies and links them The components of the disc are (NP), Annulus fibrosus (AF) the end-plates. Although the phenotype of cells and the composition of the extracellular matrix (ECM) is still the subject of considerable debate, they appear quite compa... | bAcKgROund
==========
tHe InteRVertEBRaL diSC (iVD) LIes BeTWeEN thE VeRtEbRAl BOdIes aNd liNKS THEm TogEThER. The ComPonEnts OF thE dISC are nUCLEUs puLPOsuS (NP), AnnUlUS FiBroSuS (Af) And thE eND-PLaTeS. aLTHoUGH tHE phenOtype of Ivd cElLS anD THe comPOSItION Of tHe extRaCELLular MATRIx (eCM) IS STIll THe SuBJECT O... | Background ========== The intervertebral disc (IVD) lies between the vertebral bodies and links them together. The components of the disc are Nucleus pulposus(NP), Annulus fibrosus(AF) and the end-plates. Although the phenotype of IVD cellsand the composition of the extracellular matrix (ECM) is stil... | Background ========== The intervertebral disc (IVD) lies between the vertebral bodies and links _them_ together. The components _of_ the disc are Nucleus pulposus (NP), Annulus fibrosus (AF) and _the_ end-plates. _Although_ the phenotype of IVD cells and the composition _of_ the extracellular matrix (ECM) is still the ... |
Current constraints in blood glucose monitoring and insulin delivery technologies limit the ability of most individuals with type 1 diabetes to safely achieve and maintain recommended glucose and hemoglobin A~1c~ (HbA~1c~) targets. Severe hypoglycemia (SH) remains a common side effect of intensive treatment and a major... | current constraints in blood glucose monitoring and insulin delivery technologies limit the ability of most individuals with type 1 diabetes to safely achieve and maintain recommended glucose and hemoglobin a ~ 1c ~ ( hba ~ 1c ~ ) targets. cerebral hypoglycemia ( sh ) remains a common side effect of intensive treatment... | Current constraints in blood glucose monitoring and insulin delivery technologies limit the ability of most individuals with type 1 diabetes to safely achieve and maintain recommended glucose and hemoglobin A ~ 1c ~ (HbA ~ 1c ~) targets. Severe hypoglycemia (SH) remains a common side effect of intensive treatment and a... | Current constraints in blood glucose monitoring insulin delivery technologies limit the of individuals with type 1 diabetes to safely achieve and maintain recommended glucose and hemoglobin A~1c~ (HbA~1c~) targets. Severe hypoglycemia (SH) remains a common side of treatment and a major achieving normoglycemia in type 1... | CURrenT COnStrAINTs in blOod GLucOsE MoNitoriNg And INSuliN deLIvEry tEcHnoloGIeS LIMIt tHE ABIlItY oF MOst IndIviduals wITH TYpE 1 dIaBETES TO SaFEly AChieve And maiNTAIN reCOMMenDed GlUCOsE AnD HeMoGlOBIN a~1c~ (hbA~1C~) tARgets. SEVerE HypOgLyCEMiA (Sh) reMainS A ComMoN side efFeCT of iNTeNSIVE treATMENt ANd a maJOR... | Current constraints in bloodglucose monitoring and insulin delivery technologies limit the ability of most individuals with type 1 diabetesto safely achieve and maintain recommended glucose and hemoglobin A~1c~(HbA~1c~) targets. Severehypoglycemia (SH) remains a common side effect of int... | Current _constraints_ _in_ blood glucose monitoring and insulin _delivery_ technologies _limit_ the ability of most individuals _with_ type 1 diabetes to safely achieve and maintain recommended glucose _and_ hemoglobin A~1c~ _(HbA~1c~)_ targets. _Severe_ hypoglycemia (SH) remains a common side effect of intensive treat... |
Introduction
============
The use of bicycles by children is a common and desirable activity in Canadian society. Several types of bicycle helmet legislation for young people have recently been adopted in various Canadian jurisdictions in an attempt to make bicycling a safer activity. In this paper, we examine bicycle... | introduction = = = = = = = = = = = = the use of bicycles by children is a common and desirable activity in canadian society. several types of bicycle helmet legislation for young people have simultaneously been adopted in various canadian jurisdictions in an attempt to make bicycling a safer activity. in this paper, we... | Introduction = = = = = = = = = = = = The use of bicycles by children is a common and desirable activity in Canadian society. Several types of bicycle helmet legislation for young people have recently been adopted in various Canadian jurisdictions in an attempt to make bicycling a safer activity. In this paper, we exami... | Introduction ============ The use of bicycles by children is a common and desirable activity in society. Several types of bicycle helmet legislation for young people have recently been adopted in various Canadian jurisdictions in an attempt to make bicycling a safer activity. In paper, we examine bicycle helmet use and... | INTroDuCtIOn
============
thE USE Of biCyCLeS BY chiLDren iS A COmmOn and DESirAble AcTIviTy in caNaDIaN SOcietY. SEVERAL tYpEs Of biCYclE hElMET LegisLATIOn foR YouNG peOpLE HAVe REcEnTLy Been adoPted IN VaRIoUS CANaDiAN jURisDictions IN AN ATtEmPT TO MAkE bICYCling a sAfer ActiVItY. in THis PaPEr, wE EXAmiNe BicycLe... | Introduction ============ The use of bicycles by children is a common and desirable activity in Canadian society. Several types of bicycle helmetlegislationfor young people have recently been adopted in variousCanadian jurisdictionsin an attempt to make bicycling a safer activity. In thispaper,we exa... | Introduction ============ The use of bicycles by children is a common and _desirable_ activity in Canadian society. Several types of bicycle helmet legislation for _young_ people _have_ recently been adopted _in_ various Canadian jurisdictions _in_ an attempt to make bicycling a safer _activity._ _In_ _this_ _paper,_ w... |
Introduction {#sec1_1}
============
Stroke is the fifth leading cause of mortality in the United States. Nearly 90% of all stroke cases are ischemic in nature \[[@B1]\]. Rapid assessment of patient eligibility for intravenous recombinant tissue plasminogen activator (rt-PA) is critical in these cases to re-establish b... | introduction { # sec1 _ 1 } = = = = = = = = = = = = stroke is the fifth leading cause of mortality in the united states. nearly 90 % of all stroke cases are ischemic in nature \ [ [ @ b1 ] \ ]. rapid assessment of patient eligibility for intravenous recombinant tissue plasminogen activator ( rt - pa ) is critical in th... | Introduction {# sec1_1} = = = = = = = = = = = = Stroke is the fifth leading cause of mortality in the United States. Nearly 90% of all stroke cases are ischemic in nature \ [[ @ B1] \ ]. Rapid assessment of patient eligibility for intravenous recombinant tissue plasminogen activator (rt - PA) is critical in these cases... | Introduction ============ Stroke is the fifth leading cause of mortality in United States. Nearly 90% of all cases are ischemic in nature \[[@B1]\]. Rapid assessment of patient eligibility for intravenous recombinant tissue plasminogen activator (rt-PA) is critical these cases to re-establish blood flow to the ischemic... | inTrOductIOn {#seC1_1}
============
strokE Is THE FIFTH leaDiNg caUSe Of MoRTality In THe uNITED sTAtEs. nearLy 90% OF all stRoke casES Are iScHEmIc In natuRE \[[@b1]\]. RAPid aSSEssMEnt Of pAtiEnt ElIGIBiliTy For INtRAVeNoUs REcombiNanT TissUe PlAsMINoGEN actIVATOr (rt-pA) iS CRItiCaL in thEsE cASeS to rE-EStaBLisH b... | Introduction {#sec1_1} ============Stroke is the fifth leading cause of mortality in the United States. Nearly 90%of all stroke cases are ischemic in nature\[[@B1]\]. Rapid assessment of patient eligibility for intravenousrecombinant tissue plasminogenactivator (rt-PA) is critical in these cases to re-establish blo... | Introduction {#sec1_1} ============ _Stroke_ is the _fifth_ _leading_ cause of mortality _in_ the United States. _Nearly_ 90% of _all_ stroke cases are ischemic in _nature_ \[[@B1]\]. Rapid assessment of patient _eligibility_ for intravenous recombinant tissue plasminogen _activator_ _(rt-PA)_ is _critical_ _in_ these ... |
In the original article, there was a mistake in Figure 1 and Figure 2 as published. The coefficients for the effects of the experimental intervention condition on thought related test anxiety were mistakenly reported as negative even though the coefficients for these effects are positive. The corrected Figure [1](#F1){... | in the original article, there was a mistake covering figure 1 and figure 2 as published. the coefficients for the effects of the experimental intervention condition on thought related test anxiety were mistakenly reported as negative even though the coefficients for these effects are positive. the corrected figure [ 1... | In the original article, there was a mistake in Figure 1 and Figure 2 as published. The coefficients for the effects of the experimental intervention condition on thought related test anxiety were mistakenly reported as negative even though the coefficients for these effects are positive. The corrected Figure [1] (# F1... | In the original article, there was a mistake in Figure and Figure 2 as published. coefficients for the effects of the experimental intervention condition on thought related anxiety were mistakenly reported as negative even though the coefficients for these are positive. The corrected Figure [1](#F1){ref-type="fig"} and... | iN The ORiginAl ArTiCLe, TheRe Was A mISTAke IN FIGuRe 1 AnD FIguRE 2 aS pUbLISHed. ThE coefFIciENts FoR the EfFectS oF THe expeRiMENtal iNterventIOn conDItiOn On THoUght ReLAtED tESt AnXIetY werE miStakEnLY rEPOrtEd as nEGaTive EVeN ThOuGh tHE cOeFFicIEnTs fOr ThesE efFeCts ARE pOSItiVE. thE COrRectEd figuRE [1](#F1){... | In the original article, there was a mistake in Figure 1 and Figure 2 as published.The coefficients for theeffects of the experimental intervention condition on thought related test anxiety were mistakenlyreported as negative even though thecoefficients forthese effectsare positive.The corrected Fi... | In the _original_ article, there was a mistake in Figure 1 and Figure 2 _as_ published. The coefficients _for_ the _effects_ of the experimental intervention condition on thought related test anxiety were mistakenly reported as negative _even_ though the _coefficients_ for these effects are positive. The corrected Figu... |
Introduction
============
Nowadays, online crowdsourcing is one of the widely used methods for conducting behavioral experiments with large numbers of people. In comparison to the traditional way of performing offline experiments, crowdsourcing on the Internet enables researchers to collect massive amounts of data and r... | introduction = = = = = = = = = = = = nowadays, online crowdsourcing is one of the widely used methods for conducting behavioral experiments with large numbers of people. in comparison to the traditional way of performing [UNK] experiments, crowdsourcing on the internet enables researchers to collect massive amounts of ... | Introduction = = = = = = = = = = = = Nowadays, online crowdsourcing is one of the widely used methods for conducting behavioral experiments with large numbers of people. In comparison to the traditional way of performing offline experiments, crowdsourcing on the Internet enables researchers to collect massive amounts of ... | ============ Nowadays, online crowdsourcing is one of the widely used methods conducting behavioral experiments with large numbers of In comparison to the traditional of performing offline experiments, crowdsourcing on the Internet enables researchers to collect massive amounts of data and requires less effort recruit pa... | INtrODuCtIon
============
NOwAdAyS, OnlInE CrowdSOuRCING IS one Of ThE WidELY USeD methODs foR COnduCTIng BehAviORAl ExpeRimEnTS wITh lARgE NumBERs of PEoplE. In comPAriSOn tO The TrADItIoNAl wAy Of pERFORmiNG OfflINE exPERImenTS, CRoWdSOuRcing oN ThE InTeRNeT EnaBlES RESeaRCHErs To COLLEcT masSIVe amouNts OF Data and R... | Introduction ============ Nowadays, online crowdsourcing is one of the widely used methods for conducting behavioral experiments with largenumbers of people. Incomparison to the traditional wayof performing offline experiments, crowdsourcing on the Internet enablesresearchers to collectmassive amounts of data and ... | Introduction _============_ Nowadays, online crowdsourcing is one of the widely used methods _for_ conducting behavioral experiments with large numbers of people. In _comparison_ to the traditional way of performing offline experiments, crowdsourcing on the Internet _enables_ researchers to _collect_ massive amounts of _... |
All relevant data are within the manuscript and its Supporting Information files.
Introduction {#sec001}
============
The improvement of the performance of commercial banks is of great significance for the rational use of financial resources and the enhancement of the comprehensive competitiveness of China's banking ... | all relevant data are within the manuscript and its supporting information files. ″ { # sec001 } = = = = = = = = = = = = the improvement of the performance of commercial banks is of great significance for the rational use of financial resources and the assessment of the comprehensive competitiveness of china ' s bankin... | All relevant data are within the manuscript and its Supporting Information files. Iht3oduction {# sec001} = = = = = = = = = = = = The improvement of the performance of commercial banks is of great significance for the rational use of financial resources and the enhancement of the comprehensive competitiveness of China ... | All relevant data are within manuscript and its Supporting Information files. Introduction {#sec001} ============ The improvement of the performance of banks is of great significance for the rational use of financial resources and the enhancement of the comprehensive competitiveness of China's banking industry. improve... | aLl ReLevANT datA aRE wIthiN THe maNUScripT aNd iTS SUpPORTIng iNFoRmatIoN fILEs.
IntRoDUctioN {#sec001}
============
ThE IMprovEMenT oF tHe perfOrmance Of coMmErcIAL bAnKS iS OF GREAt siGnificaNcE FOR tHe RatiONaL USe of FInaNCIal resOUrCEs And tHe ENhANceMeNT OF The cOMPrEHEnsIvE ComPETITIvENess OF ChiNa'S BANkinG ... | All relevant data are within the manuscript and its Supporting Informationfiles. Introduction {#sec001} ============The improvement of the performanceof commercial banks isof great significance for the rational use of financial resources and the enhancement of the comprehensive competitiveness of Ch... | All relevant data are within the manuscript and its Supporting Information files. Introduction {#sec001} ============ The improvement of the performance of _commercial_ _banks_ is _of_ great significance for _the_ rational use of financial resources and the _enhancement_ of the comprehensive competitiveness of China's ... |
CASE REPORT {#S0001}
===========
A 68-year old woman presented with urge-incontinence, resistant to anticholinergic therapy. Urinalysis revealed a urinary tract infection caused by E. coli and cytology showed several neutrophils, but no malignant cells. Despite treatment with ciprofloxacin, the urge-incontinence persi... | case report { # 7 } = = = = = = = = = = = a 68 - year old woman presented with urge - incontinence, resistant to anticholinergic therapy. urinalysis revealed a urinary tract infection caused by e. coli and cytology showed several neutrophils, but no malignant cells. despite treatments with ciprofloxacin, the urge - inc... | CASE REPORT {# S0001} = = = = = = = = = = = A 68 - year old woman presented with urge - incontinence, resistant to anticholinergic therapy. Urinalysis revealed a urinary tract infection caused by E. coli and cytology showed several neutrophils, but no malignant cells. Despite treatment with ciprofloxacin, the urge - in... | CASE REPORT {#S0001} =========== A 68-year old presented with urge-incontinence, resistant to anticholinergic therapy. Urinalysis revealed a urinary tract infection caused by E. coli and cytology showed neutrophils, but no malignant cells. Despite treatment with ciprofloxacin, the urge-incontinence Ultrasonography reve... | caSE rEPORt {#s0001}
===========
A 68-YEaR olD WOmAn PreSEnTeD wITh urge-InCoNTiNENcE, rESiSTaNt to anTIchoLiNErgiC THerAPY. UrinALYSiS REVeaLed A uRinary tRacT INfECtion caUSeD BY E. cOli AnD cyTOLoGy ShoWeD seVEral neutROPhILs, bUt No maLignaNT cElls. DEsPITE TreATmEnt wITh CiPRofLOXACin, ThE URge-InCOntINeNCE PersI... | CASE REPORT {#S0001} ===========A68-year old woman presented with urge-incontinence,resistant to anticholinergic therapy. Urinalysis revealed a urinary tract infection caused by E. coli and cytology showed several neutrophils,but no malignant cells. Despite treatment with ciprofloxacin, the urge-incontinence persis... | _CASE_ REPORT {#S0001} _===========_ A 68-year _old_ woman presented _with_ urge-incontinence, _resistant_ to anticholinergic therapy. Urinalysis revealed _a_ urinary tract infection _caused_ by _E._ coli and cytology showed several _neutrophils,_ but no malignant cells. Despite treatment with ciprofloxacin, the _urge-... |
I. INTRODUCTION
===============
Thyroid carcinoma is rare in children, especially in patients under 10 years of age (1). In Europe, its incidence is estimated at around 1--2 cases per million in children aged 10--14 years compared to 70 cases per million in adults (2). The incidence rate is higher in females than in m... | i. introduction = = = = = = = = = = = = = = = thyroid carcinoma is common in children, especially in patients under 10 years of age ( 1 ). in europe, its incidence is estimated at around 1 - - 2 cases per million in children aged 10 - - 14 years compared to 70 cases per million in adults ( 2 ). the incidence rate is hi... | I. INTRODUCTION = = = = = = = = = = = = = = = Thyroid carcinoma is rare in children, especially in patients under 10 years of age (1 ). In Europe, its incidence is estimated at around 1 - - 2 cases per million in children aged 10 - - 14 years compared to 70 cases per million in adults (2 ). The incidence rate is higher... | I. INTRODUCTION =============== Thyroid carcinoma is rare in children, especially in under 10 years of (1). In Europe, its is estimated around 1--2 cases per million in children aged 10--14 years compared to 70 cases million in (2). The incidence rate is in females than in with a sex ratio ranging from 2:1 in children ... | i. iNtroDUCTIoN
===============
thYroiD CARCINomA Is RARE In ChiLdRen, EsPECIallY in PAtIeNtS UNDER 10 YEaRs of AGe (1). In eUroPe, ITS INCidEncE iS estIMATed aT aRoUnD 1--2 CaSEs pEr MILLiON In ChIldReN AgeD 10--14 Years cOMPareD tO 70 cAseS pEr mILLiON IN aDulTS (2). THe INciDEnCE raTE iS HighER in FemAlES thAn IN M... | I. INTRODUCTION =============== Thyroid carcinoma is rare in children,especially in patients under 10 years of age(1). In Europe,its incidence is estimated at around1--2 cases permillion in children aged 10--14 years compared to 70 cases per million in adults (2).The incidence rateis higher in females than in ma... | I. INTRODUCTION =============== Thyroid carcinoma is rare in children, especially _in_ patients under _10_ _years_ of age (1). _In_ _Europe,_ its incidence _is_ estimated _at_ _around_ _1--2_ cases _per_ million in children aged 10--14 years _compared_ to 70 cases per million in _adults_ (2). _The_ incidence _rate_ is ... |
Introduction {#Sec1}
============
It has been well established that the cyclical development of the mammary gland in mammals represents a valuable model of the processes underlying cell differentiation for the dynamic remodeling of the organ and of its function, in this case, the production and secretion of milk. This... | introduction { # sec1 } = = = = = = = = = = = = it has been well established that the cyclical development of the mammary gland in mammals represents a valuable model of the processes of cell differentiation for the dynamic remodeling of the organ and of its function, in this case, the production and secretion of milk.... | Introduction {# Sec1} = = = = = = = = = = = = It has been well established that the cyclical development of the mammary gland in mammals represents a valuable model of the processes underlying cell differentiation for the dynamic remodeling of the organ and of its function, in this case, the production and secretion of... | Introduction {#Sec1} ============ It has been well that the cyclical of the mammary in mammals represents a valuable model of the processes underlying differentiation for the dynamic of the and of its in this case, the production and secretion of milk. This interest was further strengthened 2006 two studies showed the ... | InTrODUctiOn {#seC1}
============
it hAs BeEn wELL esTAblISHed That tHe CYCLICAl DeVELopMEnt of THe mAMmARy glANd In MAMmALS REpReseNts A valuabLE MODeL of ThE PrOCESses UNderlYinG CeLL dIfFerEntiation For tHE dYnAMIc REmoDELiNG oF thE orGAN And of its FuNCTIon, in THis CaSE, The pRodUCTION aNd sECREtIoN oF MIlk. THis... | Introduction{#Sec1} ============ It has been well established that the cyclical development of the mammary gland in mammals represents a valuable modelof theprocesses underlying cell differentiation for the dynamic remodeling of the organ and of its function, in this case, the production and secr... | Introduction {#Sec1} ============ _It_ has been well _established_ that the cyclical development of _the_ mammary gland in mammals represents a valuable model _of_ the processes underlying cell _differentiation_ for _the_ dynamic remodeling _of_ the organ _and_ of its function, in this case, the production _and_ secret... |
Introduction
============
Compared with endoscopic mucosal resection (EMR) for early gastric cancer (EGC), endoscopic submucosal dissection (ESD) has considerable advantages regarding rates of en-bloc resection, curative resection, and local recurrence [@JR221-1] [@JR221-2] [@JR221-3] [@JR221-4] [@JR221-5]. EMR has su... | introduction = = = = = = = = = = = = compared with endoscopic mucosal resection ( emr ) for early gastric cancer ( egc ), endoscopic submucosal compression ( ct ) has considerable advantages regarding rates of en - situ resection, curative resection, and local recurrence [ @ jr221 - 1 ] [ @ jr221 - 2 ] [ @ jr221 - 3 ] ... | Introduction = = = = = = = = = = = = Compared with endoscopic mucosal resection (EMR) for early gastric cancer (EGC ), endoscopic submucosal dissection (ESD) has considerable advantages regarding rates of en - bloc resection, curative resection, and local recurrence [@ JR221 - 1] [@ JR221 - 2] [@ JR221 - 3] [@ JR221 - ... | Introduction ============ Compared with endoscopic mucosal resection (EMR) early gastric cancer (EGC), submucosal dissection has considerable advantages regarding rates en-bloc curative resection, and local recurrence [@JR221-1] [@JR221-2] [@JR221-3] [@JR221-4] [@JR221-5]. EMR has subsequently replaced ESD. The main pr... | InTRODUcTIon
============
COmPARed wITh ENdOsCOPIC MucosAL reSECtIoN (EMR) for eArLy GastriC cANCER (eGc), EnDosCoPic submuCOSAl DISSectIOn (esD) Has CoNsidERAbLE ADvantaGes rEgardInG RATES OF EN-BlOc reSecTIon, curaTIvE REsECtiOn, And lOcaL reCUrreNce [@Jr221-1] [@JR221-2] [@jr221-3] [@Jr221-4] [@jR221-5]. emr hAs Su... | Introduction ============ Compared withendoscopic mucosal resection (EMR) forearly gastriccancer (EGC), endoscopicsubmucosal dissection (ESD) has considerable advantages regarding rates of en-bloc resection, curative resection, and local recurrence [@JR221-1] [@JR221-2][@JR221-3] [@JR221-4][@JR221-5]. EM... | _Introduction_ ============ Compared with endoscopic mucosal _resection_ (EMR) for _early_ gastric cancer (EGC), endoscopic submucosal dissection (ESD) has _considerable_ _advantages_ regarding rates of en-bloc resection, curative resection, and local _recurrence_ [@JR221-1] [@JR221-2] [@JR221-3] _[@JR221-4]_ [@JR221-5... |
Introduction
============
Aggressive mature B-cell lymphomas harboring concurrent translocations of 8q24/*MYC* mainly with 18q21/*BCL2* are called "double-hit lymphomas (DHL)" now referred to as "high grade B-cell lymphoma with *MYC* and *BCL2* and/or *BCL6* rearrangements (DH-HGBL)" according to the current World Hea... | introduction = = = = = = = = = = = = aggressive mature b - cell lymphomas harboring concurrent translocations between 8q24 / * myc * mainly with 18q21 / * bcl2 * are called " double - hit lymphomas ( dhl ) " now referred to as " high dependency b - cell lymphoma with * myc * and * bcl2 * and / or * bcl6 * rearrangement... | Introduction = = = = = = = = = = = = AgTreswive mature B - cell lymphomas harboring concurrent translocations of 8q24 / * MYC * mainly with 18q21 / * BCL2 * are called " double - hit lymphomas (DHL) " now referred to as " high grade B - cell lymphoma with * MYC * and * BCL2 * and / or * BCL6 * rearrangements (DH - HGBL... | Introduction Aggressive mature harboring concurrent translocations of 8q24/*MYC* mainly with 18q21/*BCL2* are called "double-hit lymphomas (DHL)" now referred to as "high grade B-cell with *MYC* and *BCL2* and/or *BCL6* rearrangements (DH-HGBL)" according to the current World Organization (WHO) of lymphoid neoplasms.^[... | INTRODUCtION
============
AggreSsIVe MATuRe B-CelL lYMPhomAS haRbOriNg coNCURREnT tRansloCATIOns of 8Q24/*myC* mAINly WIth 18q21/*bcL2* aRe cAlled "DoUBlE-HIt LYmPhOmas (Dhl)" noW REFERRED To as "higH gRADe B-CElL LYMphOma WITH *MyC* And *bcL2* and/Or *bcL6* rEarraNGEmeNtS (dh-hgBl)" aCcoRdING tO The CUrREnT WorlD Hea... | Introduction ============ Aggressive mature B-cell lymphomas harboring concurrent translocations of 8q24/*MYC* mainly with 18q21/*BCL2* are called"double-hit lymphomas (DHL)" nowreferred to as "high grade B-cell lymphoma with *MYC* and *BCL2* and/or *BCL6* rearrangements (DH-HGBL)"according to the currentWorld Hea... | _Introduction_ ============ Aggressive _mature_ B-cell lymphomas harboring concurrent translocations of 8q24/*MYC* mainly with 18q21/*BCL2* are called "double-hit lymphomas (DHL)" now referred _to_ _as_ _"high_ _grade_ B-cell lymphoma with *MYC* _and_ *BCL2* and/or *BCL6* rearrangements (DH-HGBL)" according _to_ the _c... |
Case presentation
=================
A 46-year-old Caucasian woman presented to the gynaecology outpatient\'s department complaining of menorrhagia, bladder pressure and a feeling of heaviness in the pelvis. She had recently also started experiencing deep dyspareunia. She reported no bowel or constitutional symptoms.
... | case presentation = = = = = = = = = = = = = = = = = a 46 - year - old caucasian woman presented to the gynaecology outpatient \ ' s department complaining of menorrhagia, bladder pressure and a feeling of heaviness in the pelvis. barrett had recently also started experiencing deep dyspareunia. she reported no bowel or ... | Case presentation = = = = = = = = = = = = = = = = = A 46 - year - old Caucasian woman presented to the gynaecology outpatient \ ' s department complaining of menorrhagia, bladder pressure and a feeling of heaviness in the pelvis. She had recently also started experiencing deep dyspareunia. She reported no bowel or cons... | Case presentation ================= A Caucasian woman presented to the gynaecology outpatient\'s department complaining of menorrhagia, bladder pressure and a feeling of heaviness in the She had recently also started experiencing deep dyspareunia. She no bowel or constitutional She a housewife and was non-smoker. She h... | cAsE pREseNtATion
=================
A 46-YeaR-OLD cAuCaSIAn woMan preSeNteD tO tHe GYNAeCoLOGy OUTpatiEnt\'s dEPaRtMENt cOmPLAininG Of menoRrHaGia, bladder pREssUre AND a FEELING oF HEAVinEss IN the PELvIs. SHe Had rEcenTlY aLSO STArteD expERIEnciNG DeEp dySparEUnIa. she rEPORTeD nO BOWEL OR ConSTItutIONaL SyMptOMS.
... | Case presentation ================= A 46-year-old Caucasian woman presented to the gynaecology outpatient\'s department complaining of menorrhagia, bladder pressure and a feeling of heaviness in the pelvis. She had recently also started experiencing deep dyspareunia.She reported no bowel or constit... | Case presentation _=================_ _A_ 46-year-old Caucasian woman presented to the _gynaecology_ outpatient\'s department complaining of _menorrhagia,_ _bladder_ pressure and a feeling of _heaviness_ in the pelvis. She _had_ _recently_ also started experiencing deep dyspareunia. _She_ _reported_ no bowel or constit... |
Introduction {#s1}
============
Working memory enables us to remember, manipulate, and reorganize information for short periods of time (Salthouse et al., [@B46]; Baddeley, [@B2], [@B3]). This executive memory process is fundamental for everyday life and is known to decline with advanced age (Li et al., [@B27]; Gazzal... | introduction { # s1 } = = = = = = = = = = = = working memory enables us could remember, manipulate, and reorganize information for short periods of time ( salthouse et al., [ @ b46 ] ; baddeley, [ @ b2 ], [ @ b3 ] ). chronic executive memory process is fundamental for everyday life and is known to decline with advanced... | Introduction {# s1} = = = = = = = = = = = = Working memory enables us to remember, manipulate, and reorganize information for short periods of time (Salthouse et al. , [@ B46 ]; Baddeley, [@ B2 ], [@ B3] ). This executive memory process is fundamental for everyday life and is known to decline with advanced age (Li et a... | Introduction {#s1} ============ Working enables us to remember, and reorganize information for short periods of time (Salthouse et al., [@B46]; Baddeley, [@B2], [@B3]). executive memory process is fundamental for everyday life and is known to decline with advanced age (Li et Gazzaley et al., [@B16]). Age-related declin... | iNtROdUCtIOn {#s1}
============
WorKINg MemoRy eNabLEs US tO rEmeMBER, mANipUlaTe, aNd rEorgaNIZe InfORMaTion foR sHORT PErIODS oF tIME (SAlThOUSe ET Al., [@B46]; baddElEY, [@b2], [@B3]). tHIS EXEcUTive MeMoRY PROcess IS fuNdAMenTal For eVerYDAy liFE ANd Is KnoWn tO DeclInE wITH advanCeD AgE (LI ET AL., [@b27]; GAzZAL... | Introduction {#s1}============ Working memoryenables us to remember, manipulate, and reorganize information for short periods of time (Salthouse et al., [@B46]; Baddeley, [@B2], [@B3]). This executive memoryprocess is fundamental for everyday life and is known to decline withadvanced age (Li et al., [@... | _Introduction_ {#s1} ============ Working memory enables us to remember, manipulate, _and_ _reorganize_ information _for_ short periods _of_ _time_ (Salthouse et al., _[@B46];_ Baddeley, _[@B2],_ [@B3]). This executive _memory_ process is fundamental for everyday life and is known _to_ decline with advanced age (Li et ... |
Background
==========
Education level is one indicator of socioeconomic position which, in several countries including South Korea, is provided though death certificate data. Its validity determines the usefulness of death certificate data for exploring the association between socioeconomic position and mortality \[[@... | background = = = = = = = = = = education ∗ is one indicator of socioeconomic position which, in several countries including south korea, is provided though death certificate data. its validity determines the usefulness of death certificate data for exploring the association between socioeconomic position and mortality ... | Background = = = = = = = = = = Education level is one indicator of socioeconomic position which, in several countries including South Korea, is provided though death certificate data. Its validity determines the usefulness of death certificate data for exploring the association between socioeconomic position and mortal... | Background ========== Education is one indicator of socioeconomic position in several countries including South Korea, is provided death certificate data. Its validity the usefulness of certificate data for exploring the association between position and mortality \[[@B1]\]. Although education is likely to be accurately... | BAcKground
==========
eDUcAtIon LevEL IS ONe IndIcAToR OF SoCIOECONomIc posITION whICH, in sevEraL cOuNTries iNcluDIng south kOreA, is prOvided thOuGh DEAtH cerTificaTe DATa. its VALIdITY detERmINES the USEFULness OF dEAth CeRTiFICaTE daTA fOr ExPlOrInG THE ASsociaTioN betWeeN SoCIOECONoMic POSitIoN AnD mortalIty \[[@... | Background ========== Education level is one indicator of socioeconomic position which, in several countriesincluding South Korea, is provided though death certificate data. Its validity determinesthe usefulness of death certificate data for exploring the association between socioeconomic position and mortality\[[@B1... | Background ========== Education level is one indicator of socioeconomic position which, in several countries including South Korea, is provided _though_ death certificate _data._ Its validity determines the usefulness of death certificate data _for_ exploring the _association_ between socioeconomic position and _mortal... |
Introduction {#Sec1}
============
Coronary heart disease is one of the leading causes of mortality in the world today (MacKay & Mensah, [@CR27]; Murray & Lopez, [@CR31]), and although new cardiac treatments have helped fight coronary heart disease in recent years, an estimated 1/3 of coronary heart disease risk factor... | introduction { # sec1 } = = = = = = = = = = = = coronary heart disease is one of the leading causes of mortality in the world today ( mackay & mensah, [ @ cr27 ] ; murray & lopez, [ @ cr31 ] ), and although additional genetic treatments have helped fight coronary heart disease in recent years, an estimated 1 / 3 of cor... | Introduction {# Sec1} = = = = = = = = = = = = Coronary heart disease is one of the leading causes of mortality in the world today (MacKay & Mensah, [@ CR27 ]; Murray & Lopez, [@ CR31] ), and although new cardiac treatments have helped fight coronary heart disease in recent years, an estimated 1 / 3 of coronary heart di... | Introduction {#Sec1} ============ Coronary disease is one of the leading causes of in the world today (MacKay & Mensah, [@CR27]; Murray & Lopez, [@CR31]), and although new cardiac treatments have helped coronary heart disease in recent years, an estimated 1/3 of coronary disease risk factors remain elusive (Gudnason, [... | iNtrODuCtiOn {#SeC1}
============
coROnAry HeaRT dIsEASE is onE OF the LEAding CausES oF MorTAliTY in tHe WORlD TOdAY (MaCKAy & mENSAh, [@Cr27]; mURray & lOPez, [@Cr31]), ANd ALtHoUgH nEw cARdIac TReAtmeNtS HaVe hElPED FIgHT COrOnAry heart DISEaSE in recenT yeArS, AN estImATeD 1/3 Of CorOnaRY heART DISEase RISK fACTor... | Introduction {#Sec1} ============ Coronary heart disease is one oftheleading causes of mortality in the world today (MacKay& Mensah, [@CR27];Murray & Lopez,[@CR31]), and although new cardiac treatments have helped fight coronary heartdisease in recent years, an estimated 1/3 ofcoronary heart disease ris... | Introduction {#Sec1} ============ Coronary _heart_ _disease_ is one of the leading causes _of_ mortality in _the_ world today (MacKay & Mensah, [@CR27]; _Murray_ _&_ _Lopez,_ _[@CR31]),_ and although _new_ cardiac treatments have helped fight coronary heart disease _in_ _recent_ years, _an_ estimated 1/3 of coronary he... |
1. Introduction
===============
Airway stenosis is a potentially life-threatening condition, which may be caused by tumor invasion or benign diseases, such as, endotracheal intubation injury, endobronchial tuberculosis, and thoracic trauma. Most of these patients may be too sick to undergo definitive open surgery or m... | 1. introduction = = = = = = = = = = = = = = = airway stenosis is a potentially life - threatening condition, which may be caused by tumor invasion or benign diseases, such as, endotracheal intubation injury, endobronchial tuberculosis, and thoracic trauma. most of these patients may be too sick to undergo definitive op... | 1. Introduction = = = = = = = = = = = = = = = Airway stenosis is a potentially life - threatening condition, which may be caused by tumor invasion or benign diseases, such as, endotracheal intubation injury, endobronchial tuberculosis, and thoracic trauma. Most of these patients may be too sick to undergo definitive op... | 1. Introduction =============== Airway stenosis is a life-threatening condition, which may be caused by tumor invasion or diseases, such as, endotracheal intubation injury, endobronchial tuberculosis, and trauma. Most of these patients may be too sick to undergo definitive open surgery or may not be willing undergo und... | 1. iNtRodUctION
===============
aIrWaY STeNoSis iS a poTeNTIaLly Life-THReaTENIng COnDiTIOn, WhicH MAy BE cAUSEd BY tUmor InvASion OR Benign DISeAseS, Such as, EndOTraCHEAl IntUBATiOn InjUry, eNdoBroNcHiAl TUBErCULOsIs, AnD ThORaCIc TraUma. MOST Of tHESE paTIeNTS mAY Be TOo sIcK to uNDergO DeFinItive Open suRgEry Or M... | 1. Introduction=============== Airway stenosis is a potentially life-threateningcondition, which may be causedby tumor invasion or benign diseases, suchas,endotrachealintubation injury, endobronchial tuberculosis,and thoracic trauma. Mostof thesepatientsmaybe too sick to undergo definitive open su... | 1. Introduction _===============_ Airway stenosis is a _potentially_ life-threatening condition, which may be caused _by_ tumor _invasion_ _or_ benign diseases, such as, endotracheal intubation _injury,_ endobronchial _tuberculosis,_ _and_ thoracic trauma. Most _of_ _these_ _patients_ may be _too_ sick to undergo defin... |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
During meiosis, the accurate segregation of chromosomes relies on the formation of crossovers (COs) and sister chromatid cohesion \[[@pbio.1002412.ref001]\]. COs are produced by homologous recombination (H... | all relevant data remain from the paper and its supporting information files. introduction { # sec001 } = = = = = = = = = = = = during meiosis, the accurate segregation of chromosomes relies on the formation of genes ( cos ) and sister chromatid cohesion \ [ [ @ pbio. 1002412. ref001 ] \ ]. cos are produced by homologo... | All relevant data are within the paper and its Supporting Information files. Introduction {# sec001} = = = = = = = = = = = = During meiosis, the accurate segregation of chromosomes relies on the formation of crossovers (COs) and sister chromatid cohesion \ [[ @ pbio. 1002412. ref001] \ ]. COs are produced by homologous... | All relevant data within paper and Supporting Information files. Introduction {#sec001} ============ During meiosis, the accurate segregation of chromosomes relies the formation of crossovers (COs) and sister chromatid cohesion \[[@pbio.1002412.ref001]\]. COs produced by homologous recombination (HR)-mediated repair of... | All ReLevAnT DatA ARE wiTHIn ThE PAPEr aNd Its sUPPoRTInG INformatIoN FilES.
InTROductioN {#sEc001}
============
dURing mEiosis, the ACCurATE SegrEGAtiOn Of chrOMOSomes rELIes ON tHE FoRMATIoN OF crOSsoVErS (CoS) anD sisTER chRoMatiD CoheSiOn \[[@pBio.1002412.REF001]\]. cos ArE proDucEd By hOMolOGOuS rEcOmBInatioN (H... | All relevant data are within the paper and its Supporting Information files. Introduction{#sec001} ============ During meiosis, the accuratesegregation of chromosomes relies on the formation of crossovers (COs) and sister chromatid cohesion \[[@pbio.1002412.ref001]\]. COs are produced by homologous recombina... | All _relevant_ _data_ are within the paper and its _Supporting_ Information files. _Introduction_ {#sec001} ============ During meiosis, the accurate segregation of chromosomes relies on the formation of crossovers (COs) _and_ sister chromatid cohesion _\[[@pbio.1002412.ref001]\]._ COs are produced _by_ homologous _rec... |
1.. Introduction {#s1}
================
Helminths have plagued human beings even before recorded history. Today, it is estimated that roughly one-third of the almost 3 billion people who live on less than 2 USD per day in developing regions of sub-Saharan Africa, Asia and the Americas are infected with one or more spe... | 1.. introduction { # s1 } = = = = = = = = = = = = = = = = helminths have plagued human beings even before recorded history. today, it is estimated that roughly one - third of the almost 3 billion people who live on less than 2 usd per day in developing regions like sub - saharan africa, asia and the americas are infect... | 1. . Introduction {# s1} = = = = = = = = = = = = = = = = Helminths have plagued human beings even before recorded history. Today, it is estimated that roughly one - third of the almost 3 billion people who live on less than 2 USD per day in developing regions of sub - Saharan Africa, Asia and the Americas are infected ... | 1.. Introduction {#s1} ================ have plagued human beings even before recorded history. Today, is estimated roughly one-third of the almost 3 billion people live on less than 2 USD per day in developing regions of sub-Saharan Africa, Asia and the Americas are infected with one or more species helminths \[[@RSOB... | 1.. iNtroDuCTiOn {#s1}
================
HElmInTHs HAvE PLaguEd HUmaN BEINgS eVen befORe ReCOrdEd hiStOry. today, iT is eStiMateD thAT ROUgHly oNE-THiRd OF ThE ALMosT 3 bIlLioN PEoPle WHo LIvE ON LesS THaN 2 USd per DAY In DeVELoping reGions oF Sub-saharAN AFricA, asiA AnD thE aMEriCAs ARE INfeCtEd wITH ONE Or mORe SPE... | 1.. Introduction {#s1} ================ Helminths have plagued human beings even before recorded history. Today, it is estimated thatroughly one-third of the almost 3billion people who live on less than 2 USD per day in developing regions of sub-Saharan Africa, Asia andthe Americas are infected with ... | _1.._ Introduction {#s1} ================ Helminths have _plagued_ human beings even before _recorded_ history. Today, it is estimated that roughly _one-third_ of the almost 3 billion people who live on less than 2 USD per day in developing _regions_ of sub-Saharan _Africa,_ Asia and the Americas are infected with one ... |
INTRODUCTION
============
In multiple sequence alignments, information emerges as to which residues positions are important to the nature of a protein family, versus which vary freely but could be assigned undue importance during the scoring of pairwise alignments. From these multiple alignments, profile hidden Markov... | introduction = = = = = = = = = = = = in multiple sequence alignments, information emerges as to which residues positions are essential to the nature of a protein family, versus which vary freely but could be assigned undue importance during the scoring of dna alignments. from these multiple alignments, profile hidden m... | INTRODUCTION = = = = = = = = = = = = In multiple sequence alignments, information emerges as to which residues positions are important to the nature of a protein family, versus which vary freely but could be assigned undue importance during the scoring of pairwise alignments. From these multiple alignments, profile hid... | INTRODUCTION ============ In multiple alignments, information emerges as to which residues positions are to the of a protein family, versus which vary freely but could be assigned undue importance during the scoring of pairwise alignments. From these multiple hidden Markov Models (HMMs) are These probabilistic models a... | INtrOduCTiON
============
in mUltIPLe SeQUeNCE alIGNmeNts, infoRmAtiON emErGES AS TO wHich reSidUES PosiTiONS are imPORTANT tO The NaTUre oF a PRoteIn FaMiLY, VerSUS WHICH VArY fReelY bUT CouLd BE ASSIgnEd unDUE IMPOrtANcE DuRiNg The scorinG Of paIrWise ALiGNmENTS. fROm thEse muLTiplE ALIGNMeNts, prOFIlE hiDDEn maRKov... | INTRODUCTION ============ In multiple sequence alignments,information emerges as towhich residues positions are importantto the nature of a protein family, versus which vary freelybut could be assigned undue importance during thescoring of pairwise alignments. From these multiple alignments, ... | INTRODUCTION _============_ In multiple sequence alignments, information emerges _as_ to which residues positions _are_ important to the nature of _a_ _protein_ family, versus which vary _freely_ but could be _assigned_ _undue_ importance during the scoring _of_ _pairwise_ alignments. From _these_ _multiple_ alignments... |
Suberin is among the most recalcitrant plant molecular structures in soils ([@b31-27_36]). Suberin forms a protective barrier in tissues such as woody stems, roots and underground storage organs which undergo secondary growth ([@b10-27_36]). This barrier controls the flux of water and also protects plant tissues agains... | suberin is among the most recalcitrant plant molecular structures in soils ( [ @ b31 - 27 _ 36 ] ). suberin forms a protective fold in tissues such as woody stems, roots and underground storage organs which undergo secondary growth ( [ @ b10 - 27 _ 36 ] ). this barrier controls the flux of water and also protects plant... | Suberin is among the most recalcitrant plant molecular structures in soils ([ @ b31 - 27_36] ). Suberin forms a protective barrier in tissues such as woody stems, roots and underground storage organs which undergo secondary growth ([ @ b10 - 27_36] ). This barrier controls the flux of water and also protects plant tiss... | is among the most recalcitrant plant molecular structures in soils ([@b31-27_36]). Suberin forms a protective barrier in such as woody stems, roots and underground storage organs which undergo secondary growth ([@b10-27_36]). barrier controls the flux of water and also plant tissues against biotic diseases ([@b29-27_36... | sUbERIN iS aMONg THe moSt rEcaLCItraNT plAnT MOLecULAr struCTURes iN soIlS ([@b31-27_36]). SuBERin foRMS a PrOTECtIve BaRRiER iN tISSuES sUCh as WOOdY stEMS, ROots aND unDErGROUND sTOrAGE OrGAns WhIch underGO SecOndARY groWtH ([@b10-27_36]). THIs BarRIer CONTROLS ThE Flux Of wateR AnD AlSO ProTEctS plANt TiSsueS agaINS... | Suberinis among the mostrecalcitrant plant molecular structures insoils ([@b31-27_36]). Suberin formsa protective barrierin tissues such as woody stems, roots and undergroundstorage organs which undergo secondary growth ([@b10-27_36]).This barrier controls the flux of waterand also protects planttissues ag... | Suberin is among the most recalcitrant plant molecular _structures_ in soils ([@b31-27_36]). Suberin _forms_ a protective barrier in _tissues_ _such_ as woody stems, roots and underground storage organs which undergo secondary growth ([@b10-27_36]). This barrier _controls_ the flux of water _and_ also protects plant ti... |
1. Introduction {#sec1}
===============
Multilevel inverters have generally functioned as an AC voltage synthesizer to create a quasi-sinusoidal voltage i.e., rough sinusoidal waveform with desired steps using several DC power supplies \[[@bib1]\]. Hence, high number of switching components has let the multilevel inve... | 1. introduction { # sec1 } = = = = = = = = = = = = = = = multilevel inverters have generally functioned as an ac voltage synthesizer to create a quasi - sinusoidal voltage i. e., rough sinusoidal waveform with desired steps using several dc power supplies \ [ [ @ bib1 ] \ ]. hence, high number of switching components h... | 1. Introduction {# sec1} = = = = = = = = = = = = = = = Multilevel inverters have generally functioned as an AC voltage synthesizer to create a quasi - sinusoidal voltage i. e. , rough sinusoidal waveform with desired steps using several DC power supplies \ [[ @ bib1] \ ]. Hence, high number of switching components has ... | Introduction {#sec1} =============== Multilevel inverters have generally functioned as an AC voltage synthesizer to create a quasi-sinusoidal voltage i.e., rough sinusoidal waveform with desired steps using several DC power supplies \[[@bib1]\]. Hence, high number switching components has let the multilevel inverter to... | 1. INtrOduCTION {#sEc1}
===============
mUltILEVEl INVeRterS havE genERALlY fUNcTIonEd As an aC VOLTagE sYNtheSizER to CREaTe a Quasi-SINUSOiDal VOlTAGe I.e., rough siNusOidaL WaVeForM wITh DEsIred STEps usiNG SevERAL DC pOWer suPPLIES \[[@bIb1]\]. hEnce, higH NumbeR Of SWiTChiNg COmPONEntS HaS LeT THE mUlTileVeL INve... | 1. Introduction {#sec1} =============== Multilevel inverters have generally functioned as an ACvoltage synthesizer to create a quasi-sinusoidal voltage i.e.,rough sinusoidalwaveform withdesiredsteps using several DC power supplies \[[@bib1]\]. Hence, high number of switching components has letthe mul... | 1. Introduction {#sec1} =============== Multilevel inverters _have_ _generally_ functioned _as_ an AC voltage synthesizer to _create_ a quasi-sinusoidal voltage i.e., _rough_ sinusoidal waveform with desired steps using several DC _power_ supplies \[[@bib1]\]. Hence, high number of switching components has let the mult... |
Introduction
============
Left atrial (LA) size as assessed by echocardiography has been shown to have prognostic value in patients with dilated cardiomyopathy (DCM). More recently cardiac magnetic resonance (CMR) imaging studies have reported that the presence of left ventricular mid-wall late gadolinium enhancement ... | introduction = = = = = = = = = = = = left atrial ( la ) size as assessed by echocardiography has been shown to have prognostic value in patients with dilated cardiomyopathy ( dcm ). more recently cardiac magnetic resonance ( cmr ) imaging studies have reported that the presence of left ventricular mid - wall late gadol... | Introduction = = = = = = = = = = = = Left Atrkal (LA) size as assessed by echocardiography has been shown to have prognostic value in patients with dilated cardiomyopathy (DCM ). More recently cardiac magnetic resonance (CMR) imaging studies have reported that the presence of left ventricular mid - wall late gadolinium... | Introduction ============ Left atrial (LA) as assessed by echocardiography has been shown to have prognostic in patients with dilated cardiomyopathy (DCM). More recently cardiac magnetic resonance (CMR) studies have reported the presence of left ventricular mid-wall late gadolinium enhancement a of myocardial fibrosis,... | inTroducTiON
============
lEFT atriAl (La) SiZE as aSsESSEd by eChoCaRdiOgRaphy hAs bEen shown TO HaVE prOGNoSTiC VAluE In pATiEntS WiTH dilaTed CARDIomyOpatHy (DCm). mOrE RECeNTLY caRDIac mAGNeTiC reSONanCE (Cmr) iMagIng StudIeS HAve rePORtEd THaT the PReSenCe OF LEfT vENtricUlAR mid-WaLl lATE GAdolINiuM EnhAnCeMeNT ... | Introduction ============ Left atrial (LA) size as assessed by echocardiographyhas been shown to have prognostic value in patients with dilated cardiomyopathy(DCM). More recentlycardiac magnetic resonance (CMR) imaging studies have reportedthat the presence of left ventricular mid-wall late gadolinium enhance... | Introduction ============ _Left_ atrial (LA) size as assessed by echocardiography has been shown to have prognostic value _in_ patients with dilated cardiomyopathy (DCM). More _recently_ cardiac magnetic _resonance_ (CMR) imaging studies have _reported_ that the _presence_ of left ventricular mid-wall _late_ gadolinium... |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec005}
============
Lung transplantation is an established therapeutic option for patients with various types of end-stage lung disease. Internationally, the annual number of bilateral lung transplants (BLTs) is greater than ... | all relevant data are within the paper and its individual information files. introduction { # sec005 } = = = = = = = = = = = = lung transplantation is an established therapeutic option for patients with various types of end - stage lung disease. internationally, the annual number of bilateral lung transplants ( blts ) ... | All relevant data are within the paper and its Supporting Information files. Introduction {# sec005} = = = = = = = = = = = = Lung transplantation is an established therapeutic option for patients with various types of end - stage lung disease. Internationally, the annual number of bilateral lung transplants (BLTs) is g... | All relevant data are within the paper and its Supporting Information files. Introduction {#sec005} ============ transplantation is an established option for patients types of lung disease. Internationally, the number bilateral transplants is greater than that of single lung transplants (SLTs) because the better surviv... | ALl RELeVaNT dAtA aRe witHin The pAPer ANd iTS SUPpoRtING infOrMaTiON fiLes.
InTRodUctION {#seC005}
============
LunG TRanspLanTation Is An eSTAblIsHeD THerapeutIC OpTION foR patIenTs wiTh vAriOus TypEs of ENd-stagE lUNG diSeASe. iNtERNATIONallY, The ANNuaL NuMbER Of bILATEral lUng trANSPlANtS (BltS) is GreAtER THaN ... | All relevant data are within the paper and its Supporting Information files. Introduction {#sec005}============ Lung transplantation is an established therapeutic option for patients withvarious typesofend-stage lung disease. Internationally, the annual number of bilateral lung transplants (BLTs) is greater ... | _All_ relevant _data_ are within the paper and its Supporting Information _files._ Introduction _{#sec005}_ ============ _Lung_ transplantation is an established therapeutic _option_ for patients with _various_ types of end-stage lung disease. Internationally, the annual number of bilateral lung transplants _(BLTs)_ _i... |
Introduction {#S0001}
============
The health and progress of any society largely depends on the health of its women. Women experience many biological changes throughout their life that have a significant impact on their health, including pregnancy and lactation.[@CIT0001] Pregnancy changes women's lifestyle and they ... | introduction { # s0001 } = = = = = = = = = = = = the health and progress of any society largely depends on the health of its women. women experience many biological changes throughout their life that have a significant impact on our health, including pregnancy induced lactation. [ @ cit0001 ] pregnancy changes women ' ... | Introduction {# S0001} = = = = = = = = = = = = The health and progress of any society largely depends on the health of its women. Women experience mab& biological changes throughout their life that have a significant impact on their health, including pregnancy and lactation. [@ CIT0001] Pregnancy changes women ' s life... | Introduction ============ The health and progress of any society largely depends on the health of women. Women experience many biological changes throughout their life that have a significant impact on their health, including pregnancy and Pregnancy changes women's lifestyle and they should at begin to lead a healthy l... | INtrODUCTIOn {#S0001}
============
ThE heAlth anD pRoGreSs oF aNy SoCiEty larGely DePENds on tHe Health oF ITs WOMEn. wOmEn EXPeRiENce maNy BIoloGiCAL chaNges ThrOugHOuT thEiR Life ThAt havE A siGNifiCANT iMPAcT oN ThEiR HeAlTh, INCLUdinG PReGNAncY AND laCtatION.[@cIt0001] PREgnAnCy CHANGes woMeN'S lifEStYlE And TheY ... | Introduction {#S0001} ============ The health and progress of anysociety largely depends on the health of its women. Women experience many biological changes throughout their life that have a significant impacton their health, including pregnancy and lactation.[@CIT0001] Pregnancy changeswomen's lifestyl... | _Introduction_ {#S0001} ============ The health and progress _of_ any society largely depends on _the_ health _of_ its women. Women experience _many_ biological changes throughout their life that have a significant impact on their _health,_ including pregnancy and lactation.[@CIT0001] Pregnancy changes women's lifestyl... |
Related literature {#sec1}
====================
For general background to the title compound, see: Rivera *et al.* (2010[@bb6]). For related structures, see: Rivera *et al.* (2010[@bb6], 2011[@bb5]); Silversides *et al.* (2006[@bb7]).
Experimental {#sec2}
==============
{#sec2.1}
### Crystal data {#sec2.1.1}... | related literature { # sec1 } = = = = = = = = = = = = = = = = = = = = for general background to the main compound, see : rivera * et ltd. * ( 2010 [ @ bb6 ] ). for related structures, see : rivera * et al. * ( 2010 [ @ bb6 ], 2011 [ @ bb5 ] ) ; silversides * et corp. * ( 2006 [ @ bb7 ] ). experimental { # sec2 } = = = ... | Related literature {# sec1} = = = = = = = = = = = = = = = = = = = = For general background to the title c8mpo7nd, see: Rivera * et al. * (2010 [@ bb6] ). For related structures, see: Rivera * et al. * (2010 [@ bb6 ], 2011 [@ bb5] ); Silversides * et al. * (2006 [@ bb7] ). Experimental {# sec2} = = = = = = = = = = = = =... | Related {#sec1} ==================== For general background the title compound, Rivera *et al.* (2010[@bb6]). For related structures, see: Rivera *et al.* 2011[@bb5]); Silversides *et al.* (2006[@bb7]). Experimental {#sec2} {#sec2.1} Crystal data {#sec2.1.1} C~10~H~10~N~4~*M* *~r~* = 186.2Orthorhombic,*a* = 7.6404 (3) ... | relATed lItERaTure {#SEc1}
====================
foR GENerAL bAckgrOUND To ThE titLE CoMpOUND, SEE: rivERa *ET aL.* (2010[@Bb6]). For RElATed sTrUCtUREs, SEe: RiVERA *et Al.* (2010[@bB6], 2011[@bB5]); SiLvErsiDes *et al.* (2006[@Bb7]).
EXpeRiMeNtaL {#SEC2}
==============
{#seC2.1}
### cRySTAL DAtA {#sEc2.1.1}... | Related literature{#sec1} ====================For general background to thetitle compound, see: Rivera *et al.* (2010[@bb6]). For related structures, see: Rivera*et al.* (2010[@bb6], 2011[@bb5]); Silversides *etal.* (2006[@bb7]). Experimental {#sec2}============== {#sec2.1} ### Crystal data{#sec2.1.1}C~10~H... | Related literature {#sec1} ==================== For general background to the title _compound,_ see: Rivera *et al.* (2010[@bb6]). For related structures, see: _Rivera_ *et al.* (2010[@bb6], _2011[@bb5]);_ Silversides *et al.* (2006[@bb7]). Experimental {#sec2} ============== {#sec2.1} ### Crystal _data_ {#sec2.1.1} C~... |
Introduction {#Sec1}
============
Many fundamental questions concerning the mechanisms of self-renewal and differentiation of stem cells are addressed using *Drosophila* oogenesis as a model^[@CR1]^. *Drosophila* ovaries consist of ovarioles, chains of egg chambers connected to the germarium, which houses germline ste... | introduction { # sec1 } = = = = = = = = = = = = many fundamental questions concerning the mechanisms of self - renewal and differentiation of stem cells are addressed using * drosophila * oogenesis as a model ^ [ @ cr1 ] ^. * drosophila * ovaries consist of ovarioles, chains of egg clones connected to the germarium, wh... | Introduction {# Sec1} = = = = = = = = = = = = Many fundamental questions concerning the mechanisms of self - renewal and differentiation of stem cells are addressed using * Drosophila * oogenesis as a model ^ [@ CR1] ^. * Drosophila * ovaries consist of ovarioles, chains of egg chambers connected to the germarium, whic... | Introduction {#Sec1} ============ Many fundamental concerning the self-renewal and differentiation of stem cells are addressed using *Drosophila* oogenesis a model^[@CR1]^. *Drosophila* ovaries consist of ovarioles, chains of egg chambers connected to the germarium, which houses germline stem cells (GSCs). microenviron... | iNtrOducTiON {#SEC1}
============
MAny FUndaMeNTal QuEstIoNs CONcERning THE mecHANismS of selF-ReNEWal aND dIFFEREntiatIOn oF stEm CELLS aRe ADdreSSeD USiNg *DroSOPhiLA* OoGenEsIS AS A MoDeL^[@CR1]^. *DRosOpHila* OvaRiEs consiST Of OvARIoLEs, chaIns oF EGg CHambERs CoNneCTED TO THe GErMarium, WHICH hoUsEs gERmLIne STE... | Introduction {#Sec1} ============ Many fundamental questions concerning the mechanisms of self-renewalanddifferentiation of stem cells are addressed using *Drosophila* oogenesis as a model^[@CR1]^. *Drosophila* ovaries consist of ovarioles, chains of egg chambers connected to thegermarium, which hou... | Introduction _{#Sec1}_ ============ Many _fundamental_ questions concerning the _mechanisms_ _of_ self-renewal _and_ differentiation of _stem_ cells are _addressed_ using *Drosophila* oogenesis as a model^[@CR1]^. *Drosophila* ovaries consist of ovarioles, _chains_ of _egg_ chambers connected to the germarium, which ho... |
Background {#Sec1}
==========
According with the definition of Abrams et al. \[[@CR1]\], which is accepted and adopted also by recent clinical and epidemiological studies \[[@CR2], [@CR3]\], urinary incontinence (UI) is the condition in which an involuntary loss of urine occurs, which is well identifiable and can crea... | background { # sec1 } = = = = = = = = = = according with the definition of abrams et al. \ [ [ @ cr1 ] \ ], which is accepted and adopted also by recent clinical and epidemiological studies \ [ [ @ cr2 ], [ @ cr3 ] \ ], urinary incontinence ( ui ) is the condition in which the involuntary loss of urine varies, which is... | Background {# Sec1} = = = = = = = = = = According with the definition of Abrams et al. \ [[ @ CR1] \ ], which is accepted and adopted also by recent clinical and epidemiological studies \ [[ @ CR2 ], [@ CR3] \ ], urinary incontinence (UI) is the condition in which an involuntary loss of urine occurs, which is well iden... | Background {#Sec1} ========== According with the definition of Abrams et al. \[[@CR1]\], which is accepted and adopted also by recent clinical and epidemiological studies \[[@CR2], [@CR3]\], incontinence (UI) is the condition in which an involuntary loss of urine occurs, which is well identifiable and can create of a h... | BaCkgroUnD {#seC1}
==========
accORDInG WITH The definiTIoN Of abrAms eT aL. \[[@cR1]\], wHIch iS aCcEpted aNd AdoPTeD aLso by reCenT ClInIcal anD EpiDeMiOloGIcAL sTUdiES \[[@cR2], [@cr3]\], uriNARy inCoNTIneNcE (Ui) iS The coNditiOn in WhIch an inVOLuNTAry LOSs of Urine OCCuRS, WHicH iS WELl idEnTifiAble anD Can CrEa... | Background {#Sec1} ========== Accordingwiththedefinition of Abrams et al. \[[@CR1]\], which is accepted and adopted alsoby recent clinical and epidemiological studies \[[@CR2], [@CR3]\], urinary incontinence (UI) is the condition in which an involuntary loss of urine occurs, which is well identi... | Background {#Sec1} _==========_ According with the _definition_ of Abrams et al. \[[@CR1]\], which _is_ accepted and adopted also _by_ recent _clinical_ and epidemiological studies \[[@CR2], [@CR3]\], urinary incontinence (UI) is the condition in which _an_ involuntary _loss_ of urine occurs, which is _well_ identifiab... |
Introduction {#s1}
============
Congenital nephrogenic diabetes insipidus (NDI) is a rare disease caused by genetic mutations in *AVPR2* or *AQP2* ([@r1]). *AVPR2* is located at the Xq28 locus, and it encodes arginine vasopressin receptor 2 (AVPR2). Mutations in *AVPR2* have been associated with X-linked NDI. *AQP2* i... | introduction { # s1 } = = = = = = = = = = = = congenital nephrogenic diabetes 1 ( ndi ) is a rare disease caused by genetic mutations in * avpr2 * or * aqp2 * ( [ @ r1 ] ). * avpr2 * is located at the xq28 locus, and it encodes arginine vasopressin receptor 2 ( avpr2 ). mutations in * avpr2 * have been associated with ... | Introduction {# s1} = = = = = = = = = = = = Congenital nephrogenic diabetes insipidus (NDI) is a rare disease caused by genetic mutations in * AVPR2 * or * AQP2 * ([ @ r1] ). * AVPR2 * is located at the Xq28 locus, and it encodes arginine vasopressin receptor 2 (AVPR2 ). Mutations in * AVPR2 * have been associated with... | Introduction {#s1} ============ Congenital nephrogenic diabetes insipidus (NDI) is a rare disease caused by genetic mutations *AVPR2* or *AQP2* ([@r1]). *AVPR2* located at the Xq28 it encodes arginine vasopressin receptor 2 (AVPR2). *AVPR2* have been associated with X-linked NDI. *AQP2* is located at the 12q13.12 locus... | iNTROduCtION {#s1}
============
cONgENItaL nEphROGENIC DiAbETEs INsIpIdus (ndI) is A Rare dISEaSE cAusED BY gENetic mUtaTIONS in *AVPR2* oR *AQP2* ([@R1]). *AvPr2* iS LocATEd AT THE Xq28 lOcuS, aNd it eNcodeS ArGINIne VAsOprEssIN receptOr 2 (aVPr2). MutaTIoNS iN *aVpr2* haVe beeN aSSOcIATed witH X-LiNkEd ndI. *aqP2* i... | Introduction {#s1} ============ Congenital nephrogenic diabetes insipidus (NDI) is arare diseasecaused by genetic mutationsin *AVPR2* or *AQP2* ([@r1]). *AVPR2* is locatedat theXq28 locus, and it encodes arginine vasopressin receptor 2 (AVPR2). Mutations in*AVPR2* havebeen associated with X-linked NDI. *A... | Introduction {#s1} ============ _Congenital_ nephrogenic _diabetes_ insipidus (NDI) _is_ a rare disease caused _by_ genetic mutations in *AVPR2* or *AQP2* ([@r1]). *AVPR2* is located at the Xq28 locus, and _it_ _encodes_ arginine vasopressin _receptor_ 2 (AVPR2). Mutations in _*AVPR2*_ have been associated with X-linke... |
Introduction {#j_bjmg-2019-0017_s_001}
============
Alexander disease (AxD) is a rare autosomal dominant leukodystrophy with three clinical subtypes: infantile, juvenile and adult. The neonatal forms were also described
\[[@j_bjmg-2019-0017_ref_001], [@j_bjmg-2019-0017_ref_002], [@j_bjmg-2019-0017_ref_003], [@j_bjmg-... | introduction { # j _ bjmg - 2019 - 2015 _ s _ 001 } = = = = = = = = = = = = alexander disease ( axd ) is a rare autosomal dominant leukodystrophy with three clinical subtypes : infantile, juvenile and adult. the neonatal abnormalities were also described \ [ [ @ j _ bjmg - 2019 - 0017 _ ref _ 001 ], [ @ j _ bjmg - 2019... | Introduction {# j_bjmg - 2019 - 0017_s_001} = = = = = = = = = = = = Alexander disease (AxD) is a rare autosomal dominant keukodyAtrophy with three clinical subtypes: infantile, juvenile and adult. The neonatal forms were also described \ [[ @ j_bjmg - 2019 - 0017_ref_001 ], [@ j_bjmg - 2019 - 0017_ref_002 ], [@ j_bjmg ... | {#j_bjmg-2019-0017_s_001} ============ disease (AxD) is a rare autosomal dominant leukodystrophy with three clinical subtypes: infantile, and adult. The neonatal forms were also described \[[@j_bjmg-2019-0017_ref_001], [@j_bjmg-2019-0017_ref_002], [@j_bjmg-2019-0017_ref_003], [@j_bjmg-2019-0017_ref_004], [@j_bjmg-2019-... | iNTRoDUCTIOn {#j_BjMg-2019-0017_s_001}
============
aLexAnDeR DIsEASE (aXD) IS a Rare AUToSoMAl dOMinAnT leukoDySTropHY wIth tHrEe CLINICaL SuBtyPEs: InfanTIlE, JUVenILE and aDUlT. The neOnATaL forms werE AlsO dEScRibEd
\[[@j_BJMG-2019-0017_ReF_001], [@J_bjMg-2019-0017_reF_002], [@j_bjmg-2019-0017_REf_003], [@j_Bjmg-... | Introduction {#j_bjmg-2019-0017_s_001} ============Alexander disease (AxD) is a rare autosomal dominantleukodystrophywiththree clinical subtypes: infantile, juvenile and adult. The neonatal forms werealso described\[[@j_bjmg-2019-0017_ref_001],[@j_bjmg-2019-0017_ref_002],[@j_bjmg-2019-0017_ref_003], [@j_bjmg-201... | Introduction {#j_bjmg-2019-0017_s_001} ============ Alexander disease (AxD) is a _rare_ _autosomal_ dominant leukodystrophy with three clinical subtypes: infantile, juvenile _and_ adult. The neonatal forms _were_ also described \[[@j_bjmg-2019-0017_ref_001], [@j_bjmg-2019-0017_ref_002], [@j_bjmg-2019-0017_ref_003], [@j... |
Kin selection theory predicts that individuals should behave less aggressively (enhanced social tolerance) or more amicably toward closer kin than less related individuals ([@zoy082-B22], [@zoy082-B23]). In species that live in family groups, individuals may simultaneously gain indirect and direct benefits from helping... | kin selection theory predicts because individuals should behave less aggressively ( enhanced social tolerance ) or more amicably toward closer strangers than less related individuals ( [ @ zoy082 - b22 ], [ @ zoy082 - b23 ] ). in species that live in family groups, individuals may simultaneously gain indirect and direc... | Kin selection theory predicts that individuals should behave less aggressively (enhanced social tolerance) or more amicably toward closer kin than less related individuals ([ @ zoy082 - B22 ], [@ zoy082 - B23] ). In species that live in family groups, individuals may simultaneously gain indirect and direct benefits fro... | Kin selection theory predicts that individuals should less aggressively (enhanced tolerance) or more amicably toward closer kin than less related individuals ([@zoy082-B22], [@zoy082-B23]). In species that live in family groups, individuals may simultaneously gain indirect and direct benefits from helping kin. For meer... | KIn SELeCtION TheoRY PReDicts tHat InDiVIduAlS shoUld bEhAVE LEsS agGRESsIVELy (EnhANCED sOcIAL TOleRaNCE) OR MORE AMIcAbly TOward Closer kIn THan Less RelATED iNDivIduAlS ([@zOy082-B22], [@ZoY082-b23]). In SPECIEs thaT liVe IN FamiLy GROups, iNDivIdUaLS may SImUlTANEousLY GAIn inDIReCt and DIREcT bENEFiTS fROm HelPINg... | Kin selectiontheorypredicts that individuals should behave less aggressively (enhancedsocialtolerance) or more amicably toward closer kin than less relatedindividuals([@zoy082-B22],[@zoy082-B23]). In species that live in family groups, individuals may simultaneously gain indirect and direct benefits from he... | Kin selection theory predicts _that_ individuals _should_ behave less aggressively (enhanced _social_ tolerance) or more amicably toward closer _kin_ _than_ less related individuals ([@zoy082-B22], [@zoy082-B23]). In species that live _in_ _family_ groups, individuals may simultaneously gain indirect and direct _benefi... |
Background
==========
Cancer is fundamentally a disease of genomic origin. Alterations in genes and regulatory elements critical to cell cycle control lead to uncontrolled cell growth and proliferation, the common signature of all cancers. Such events can cause amplification or mutational activation of oncogenes \[[@B... | background = = = = = = = = = = it is fundamentally a disease of genomic origin. alterations in genes and regulatory elements critical to cell cycle control lead to uncontrolled cell growth and proliferation, the common signature of all cancers. such events can cause amplification and mutational activation of oncogenes ... | Background = = = = = = = = = = Cancer is fundamentally a disease of genomic origin. Alterations in genes and regulatory elements critical to cell cycle control lead to uncontrolled cell growth and proliferation, the common signature of all cancers. Such events can cause amplification or mutational activation of oncogen... | Background ========== Cancer is fundamentally a disease of genomic origin. in genes and regulatory elements critical to cycle control lead to uncontrolled cell growth and proliferation, the common of cancers. Such events can cause amplification or mutational activation of oncogenes \[[@B1],[@B2]\], deletion or mutation... | bacKgrOUnd
==========
CANcEr iS fuNdaMENTallY a diseASe OF GeNoMiC OrIGIn. ALteratiOns in gENeS AND rEGUlAtORY ELEMeNts crIticAl tO cELL cycLE coNTROl leAD tO uNCONTROllED CelL GroWth anD PrOlIferatiON, tHE cOmmoN sIgNaTuRE oF alL CanCeRs. SUCH EVENTS CaN CausE AMplIFIcATioN Or mUTATIoNAl ACTivatIoN OF ONcOgEnes \[[@B... | Background ========== Cancer is fundamentally a disease of genomic origin. Alterations in genes and regulatory elements criticaltocell cycle control lead to uncontrolledcell growth and proliferation, thecommon signature of all cancers. Such events can cause amplification or mutational activation of oncogenes \... | Background ========== Cancer is fundamentally a disease of genomic origin. Alterations in genes _and_ regulatory elements critical to cell cycle control _lead_ to uncontrolled _cell_ growth and proliferation, _the_ common signature of all cancers. Such events can _cause_ amplification _or_ mutational _activation_ of on... |
Introduction {#Sec1}
============
Breast cancer is the most common cancer diagnosed in women, with an estimated 1.7 million new cases per year worldwide^[@CR1]^. Molecular genetics studies have classified breast cancer into four major subtypes based on gene expression profiles: luminal A, luminal B, HER2-positive, and... | introduction { # sec1 } = = = = = = = = = = = = breast cancer is the most common cancer diagnosed in women, with an estimated 1. 7 million new cases per year worldwide ^ [ @ cr1 ] ^. molecular genetics studies have classified breast cancer into four major subtypes based on gene expression profiles : luminal a, luminal ... | Introduction {# Sec1} = = = = = = = = = = = = Breast cancer is the most common cancer diagnosed in women, with an estimated 1. 7 million new cases per year worldwide ^ [@ CR1] ^. Molecular genetics studies have classified breast cancer into four major subtypes based on gene expression profiles: luminal A, luminal B, HE... | Introduction {#Sec1} ============ Breast is the most common cancer diagnosed women, with an estimated 1.7 million new cases per year worldwide^[@CR1]^. Molecular genetics studies have classified breast cancer into four major subtypes based on gene expression profiles: luminal A, luminal B, HER2-positive, and basal-like... | INtROduCtiON {#SEC1}
============
brEAst caNcER is the mosT cOMmon CanceR diagNOSed iN WomeN, WItH an eSTiMAtED 1.7 mIlLIoN NEw cASES peR yEAr wOrldwIDe^[@Cr1]^. moLEcuLAr gENeTIcs sTUDies have clAsSiFied BreAST CANCer INTO FoUR MAjor SubtYPes BaSed On geNE eXpRessiON prOFiLeS: lumiNaL a, LUmiNaL B, hEr2-POSitIve, AND... | Introduction {#Sec1}============ Breast cancer is the most common cancer diagnosed in women,with an estimated 1.7 million new cases per year worldwide^[@CR1]^. Moleculargenetics studies have classified breast cancer into four major subtypes based on gene expression profiles: luminal A, lu... | Introduction {#Sec1} ============ _Breast_ _cancer_ is _the_ most common cancer diagnosed in women, with _an_ estimated _1.7_ million new cases _per_ _year_ worldwide^[@CR1]^. _Molecular_ genetics studies have classified breast cancer into four major subtypes _based_ _on_ gene expression profiles: luminal A, luminal B,... |
O.S. & F.D. contributed equally to the manuscript.
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this art... | o. s. & f. t. contributed equally to the manuscript. this article has freely accepted for publication and undergone full peer modification but has not been through the copyediting, reproduction, pagination and proofreading process, which may lead to conflicts between any version letting the version itself record. pleas... | O. S. & F. D. contributed equally to the manuscript. This article has been avcephed for publication and undergone full peer review but has not been through the cIpy3diting, tyLesettiBg, pagination and proofreading process, wt9ch may lead to Riff2rences between thoC version and the Version of e#cord. (leaZe cifF this ar... | O.S. & F.D. contributed equally to the manuscript. This article has accepted for publication and undergone full peer review but has been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between version and the Version of Record. Please cite this article doi: | O.s. & F.d. contRIBuTED eQUalLY TO thE mAnuSCrIPT.
THIs aRtIcLe Has BEen AccEpteD FOR pUBLICaTIoN and uNdeRGOnE FUlL peeR rEviEw but hAs NOT been THROuGh tHe CoPYeDiTiNG, TYpesETtInG, paGiNaTioN aNd prOOfrEaDING PrOceSs, which MAY LeAD tO difFErenCEs BeTWEen THis vErsiOn And the VeRsion OF RECoRd. pLeaSe ciTE THIs ARt... | O.S. & F.D. contributed equally tothe manuscript.This articlehasbeen accepted for publication and undergone full peer review but has not beenthrough the copyediting, typesetting, pagination and proofreading process, which may lead todifferences between this version andthe Version of Record. Please cite ... | O.S. & F.D. contributed equally _to_ _the_ manuscript. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination _and_ proofreading process, _which_ may lead to differences _between_ this version _and_ _the_ _Version_ of Record. Pleas... |
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{#sp7 .35}
{#sp8 .36}
 { # sp1. 29 }! [ ] ( brmedchirj271647 - 0037 ) { # sp2. 30 }! [ ] ( brmedchirj271647 - 0038 ) { # sp3. 32 }! [ ] ( 01 - 0039 ) { # sp4. 32 }! [ ] ( 04 - 0040 ) { # sp5. 37 }! [ ] ( 03 - 0041 ) { # sp6. 34 }! [ ] ( brmedchirj271647 - 0042 ) { # sp7. 35 }! [ ] ( brmedchirj271647 - 0043 )... | ! [] (brmedchirj271647 - 0036) {# sp1. 29 }! [] (brmedchirj271647 - 0037) {# sp2. 30 }! [] (brmedchirj271647 - 0047) {# sp3. 31 }! [] (brmedchirj271647 - 0039) {# sp4. 32 }! [] (brmedchirj271647 - 0050) {# sp5. 33 }! [] (brmedchirj271647 - 0041) {# sp6. 34 }! [] (brmedchirj271647 - 0042) {# sp7. 35 }! [] (brmedchirj271... | {#sp1 {#sp2 .30} {#sp3 .31} {#sp4 .32} {#sp5 .33} {#sp6 .34} {#sp7 .35} .36} {#sp9 [^1]: A Paper read at a Meeti... | {#SP1 .29}
{#sp2 .30}
{#sp3 .31}
{#sP4 .32}
{#sp5 .33}
{#sP6 .34}
{#SP7 .35}
{#sp8 .36}
{#sp1 .29} {#sp2 .30} {#sp3 .31} {#sp4 .32}{#sp5 .33} {#sp6.34} {#sp7 .35} {#sp8.36} {#sp1 .29} {#sp2 .30} {#sp3 .31} {#sp4 .32} {#sp5 .33} {#sp6 .34} {#sp7 .35} {#sp8 _.36}_ _, and β-catenin then transl... | INtrODucTIOn {#s1}
============
the CaNoNIcAl WNt/Β-CaTEniN SiGnaliNG paTHwAY PlaYs pIVOTaL RoLEs noT oNlY iN EaRly embrYOgeneSiS BUT ALso in StEM CeLl hOmEostAsiS AnD tumORIGenesis [@poNe.0063378-CLEVErs1]. tHE aCtiVATION oF WNt sigNaLing rESults IN The StABiliZATIon oF Β-CATeNin tHROUgH INHIbITioN Of gLYCOGen SYntha... | Introduction {#s1} ============ ThecanonicalWnt/β-catenin signaling pathway plays pivotal roles not only in earlyembryogenesis but also in stem cell homeostasis and tumorigenesis[@pone.0063378-Clevers1]. The activation of Wntsignaling results in the stabilization ofβ-cateninthrough inhibition of glyco... | Introduction {#s1} ============ The canonical _Wnt/β-catenin_ signaling pathway plays pivotal _roles_ not only _in_ early embryogenesis but also in stem _cell_ homeostasis and tumorigenesis [@pone.0063378-Clevers1]. The activation of Wnt signaling _results_ in the stabilization of β-catenin through inhibition _of_ glyc... |
Following millennia of clinical medicine\'s efforts to embrace personalized, more effective and kinder treatments, arguably, it is the lessons garnered from patients with chronic myeloid leukemia (CML) in the chronic phase (CP) that appear to be moving us closer to the prospect of precision cancer medicine.^[@R1]^ The ... | following millennia of clinical medicine \ ' s efforts to embrace personalized, more effective and kinder treatments, arguably, it is the lessons garnered from patients with chronic myeloid leukemia ( cml ) in the chronic phase ( cp ) and appear should be moving us closer to the prospect of precision cancer medicine. ^... | Following millennia of clinical medicine \ ' s efforts to embrace personalized, more effective and kinder treatments, arguably, it is the lessons garnered from patients with chronic myeloid leukemia (CML) in the chronic phase (CP) that appear to be moving us closer to the prospect of precision cancer medicine. ^ [@ R1]... | millennia of clinical efforts to embrace effective and kinder treatments, arguably, it the lessons garnered from patients with leukemia (CML) in the chronic phase (CP) that appear to be us closer to prospect of precision cancer medicine.^[@R1]^ The *BCR-ABL1* fusion gene encodes the BCR-ABL1 with a active tyrosine kina... | FoLlOWing MILLenNiA Of cLINICal mEdiciNe\'s EfforTS tO emBRacE persONAlIzEd, mOrE eFFecTIve and kinDer TREaTmeNtS, aRGuabLY, it IS thE lEssOns garNeRED fROm PaTienTs wiTH CHROnic mYEloiD leUKemIA (cML) IN ThE ChroNIC PHaSe (cP) thaT aPpEar to BE mOVINg Us CloSEr To THE Prospect OF PReciSIoN caNCer mEDiCInE.^[@r1]^ tHE ... | Following millennia of clinical medicine\'sefforts to embrace personalized, more effective and kinder treatments, arguably,it isthe lessons garneredfrom patients withchronic myeloid leukemia (CML) in the chronic phase (CP) thatappear tobe moving us closer to the prospect ofprecision cancer medicine... | Following millennia of clinical medicine\'s efforts to embrace personalized, _more_ effective and kinder treatments, arguably, it _is_ the lessons garnered from patients _with_ chronic myeloid leukemia (CML) in the chronic phase (CP) that appear to be _moving_ us closer to _the_ prospect of precision cancer medicine.^[... |
On-demand or environmentally triggered disassembly of polymers is a widely sought-after goal, as such materials would be tremendously useful in a broad range of industries, including healthcare, cosmetics, agriculture, and electronics.^[@cit1],[@cit2]^ Despite this, few synthetic polymers degrade with high sensitivity ... | on - demand or environmentally triggered disassembly of polymers is a widely sought - after goal, as such materials would be tremendously useful in a broad range of industries, including healthcare, cosmetics, agriculture, and electronics. ^ [ @ cit1 ], [ @ cit2 ] ^ despite this, few synthetic polymers degrade sufficie... | On - demand or environmentally triggered disassembly of polymers is a widely sought - after goal, as such materials would be tremendously useful in a broad range of industries, including healthcare, cosmetics, agriculture, and electronics. ^ [@ cit1 ], [@ cit2] ^ Despite this, few synthetic polymers degrade with high s... | On-demand or environmentally triggered disassembly of polymers is a widely sought-after as such materials would be tremendously in a broad range of industries, including healthcare, cosmetics, agriculture, and electronics.^[@cit1],[@cit2]^ Despite this, few synthetic polymers degrade with sensitivity in to specific Mos... | oN-DeMaNd OR ENviRONmEnTalLy tRiggerEd dISaSsEmbLy Of POlymErs Is A WIdeLy SoUghT-AftER goAL, aS suCh MaterIaLS woULD be TREmeNdOusLy useFUL IN a BRoaD RAnGe OF iNDuStRiEs, iNclUDING healThCarE, cOSMeTiCs, agricUlTure, aND ELeCTROnICS.^[@ciT1],[@cIt2]^ dEspITE ThIs, few SYNTheTIC polymeRS dEgRaDE wiTH HiGh SENSitIvITY ... | On-demand orenvironmentally triggered disassembly of polymers is a widely sought-after goal, assuch materials would be tremendously useful in a broad range ofindustries, includinghealthcare, cosmetics, agriculture, and electronics.^[@cit1],[@cit2]^Despite this, few syntheticpolymers degrade wit... | On-demand or environmentally _triggered_ disassembly of polymers is a widely sought-after goal, as such materials would be tremendously useful _in_ a broad range _of_ industries, including healthcare, cosmetics, agriculture, and electronics.^[@cit1],[@cit2]^ Despite _this,_ few synthetic polymers _degrade_ with _high_ ... |
Introduction {#s1}
============
Human mitochondrial diseases affecting the oxidative phosphorylation (OXPHOS) system can result from a large number of different mutations, both in the nuclear genome or in the maternally inherited mitochondrial DNA (mtDNA) [@pone.0008549-Schon1], [@pone.0008549-Smeitink1]. Environmenta... | introduction { # s1 } = = = = = = = = = = = = human mitochondrial diseases affecting the oxidative phosphorylation ( oxphos ) system can result from a large collection of different mutations, both in the nuclear genome or in the maternally inherited mitochondrial dna ( mtdna ) [ @ pone. 0008549 - schon1 ], [ @ cf. 0008... | Introduction {# s1} = = = = = = = = = = = = Human mitochondrial diseases affecting the oxidative phosphorylation (OXPHOS) system can result from a large number of different mifations, both in the nuclear genome or in the maternally inherited mitochondrial DNA (mtDNA) [@ pone. 0008549 - Schon1 ], [@ pone. 0008549 - Smei... | {#s1} ============ Human affecting the oxidative phosphorylation system result from a large number of different mutations, both in the nuclear or in the maternally mitochondrial DNA (mtDNA) [@pone.0008549-Schon1], [@pone.0008549-Smeitink1]. Environmental factors can also trigger or aggravate these diseases. The clinica... | iNTRODUctION {#s1}
============
HumAn mitoChONdRIAL diseASEs AFfEctIng THe oxIDAtIve PhoSpHoRYlatiON (oXphos) system cAN ReSuLT FrOM A LargE NUMBEr of dIffEReNt muTatiONs, BOtH In The NUClEaR geNoMe oR IN THe MaTERNaLly InheRitED MItOchoNdriAl dna (MtdnA) [@PONE.0008549-ScHOn1], [@PoNE.0008549-smEiTInK1]. EnVironmeNTa... | Introduction {#s1} ============ Humanmitochondrial diseasesaffecting the oxidative phosphorylation (OXPHOS) system can result from a large number of different mutations, both in the nuclear genome or in thematernally inherited mitochondrial DNA (mtDNA) [@pone.0008549-Schon1], [@pone.0008549-Smeitink1].Environm... | Introduction {#s1} ============ _Human_ mitochondrial diseases affecting the oxidative _phosphorylation_ (OXPHOS) system can result from _a_ large _number_ _of_ _different_ mutations, both in the _nuclear_ genome or in the maternally inherited mitochondrial DNA (mtDNA) [@pone.0008549-Schon1], _[@pone.0008549-Smeitink1]... |
Introduction
============
The mammary gland is an interesting model for studying gene expression since this organ experiences different cycles of differentiation and regression during adult life. In eukaryotes, gene expression is a complex process that involves DNA methylation, chromatin modification, imprinting, and ... | introduction = = = = = = = = = = = = the mammary gland is an interesting model for studying gene expression since this organ experiences different cycles of differentiation and regression during adult life. in eukaryotes, gene expression describes a complex process that involves dna methylation, chromatin modification,... | Introduction = = = = = = = = = = = = The mammary gland is an interesting model for studying gene expression since this organ experiences diTfe$ent cycles of differentiation and regression during adult life. In eukaryotes, gene expression is a complex process that involves DNA methylation, chromatin modification, imprin... | Introduction ============ The mammary gland an interesting model for studying gene expression since this organ experiences different of differentiation and regression during adult life. In eukaryotes, gene expression is a complex process that involves DNA methylation, chromatin modification, imprinting, and interfering... | iNTRODUCtioN
============
thE MammARy gLAND is AN inTeRESTiNG moDEL For StUdyinG GEnE exprESsIOn sINCe THiS oRGan EXpErieNCEs dIFfErEnT cYCLes of DIFFERentIaTION anD reGrESsIon dUrInG aDulT life. iN EukaryOteS, GEne EXpresSIon iS A COMPlEx pROcESS tHAT iNvolVES dnA mEthyLAtIon, CHRomatIN ModIfICatioN, IMpRInTING, and ... | Introduction ============ The mammary gland is an interesting model for studying gene expression since this organ experiences different cycles of differentiation and regression during adult life. In eukaryotes, gene expression is a complex process that involves DNA methylation, chromatin modific... | Introduction ============ _The_ mammary gland is an interesting model for studying _gene_ _expression_ _since_ this _organ_ experiences different cycles of differentiation and regression _during_ adult life. In eukaryotes, gene expression is a complex process that involves DNA methylation, chromatin _modification,_ imp... |
{#sp1 .478}
{#sp2 .479}
{#sp3 .480}
| ! [ ] ( ms - 39 ) { # sp1. 44 }! [ ] ( ps - 48 ) { # 304. 46 }! [ ] ( ds - 0241 ) { # 312. 46 } | ! [] (ed(nbmedsurHj72843 - 013() {# sp1. 478 }! [] (edinbmwdsurgjy2843 - 0!#0) {# sp2. 479 }! [] (edinhmeSsurgj72843 - 0@31) {# sp3. 480 } | .478} {#sp2 .479} {#sp3 .480} | {#sp1 .478}
{#SP2 .479}
{#Sp3 .480}
| {#sp1.478}{#sp2 .479} {#sp3 .480} | _{#sp1_ .478} {#sp2 .479} {#sp3 .480} |
1. Introduction {#sec1-behavsci-10-00114}
===============
Healthy parent--child interactions provide opportunities for children to accrue rich social experiences for development \[[@B1-behavsci-10-00114],[@B2-behavsci-10-00114],[@B3-behavsci-10-00114],[@B4-behavsci-10-00114],[@B5-behavsci-10-00114],[@B6-behavsci-10-00... | 1. introduction { # sec1 - behavsci - 10 - 00114 } = = = = = = = = = = = = = = = healthy parent - - child interactions provide opportunities for children to accrue rich social experiences for development \ [ [ @ b1 - behavsci - 10 - 00114 ], [ @ b2 - 10 - 10 - 00114 ], [ @ b3 - behavsci - 10 - 00114 ], [ @ b4 - behavsc... | 1. Introduction {# sec1 - behavsci - 10 - 00114} = = = = = = = = = = = = = = = Healthy parent - - child interactions provide opportunities for children to accrue rich social experiences for development \ [[ @ B1 - behavsci - 10 - 00114 ], [@ B2 - behavsci - 10 - 00114 ], [@ B3 - behavsci - 10 - 00114 ], [@ B4 - behavsc... | 1. Introduction =============== Healthy parent--child interactions provide opportunities for children to accrue rich social experiences for development \[[@B1-behavsci-10-00114],[@B2-behavsci-10-00114],[@B3-behavsci-10-00114],[@B4-behavsci-10-00114],[@B5-behavsci-10-00114],[@B6-behavsci-10-00114]\]. These dyadic exchan... | 1. iNtRoduCtiON {#Sec1-BEHAvsCI-10-00114}
===============
healthY PARENt--ChILd interAcTioNS ProViDe OpPOrtuNIties FoR cHIlDren to ACcRue rICh SociAL eXPEriencEs FoR DEVElOpMEnt \[[@b1-bEHAvsCI-10-00114],[@b2-bEhAVsCI-10-00114],[@B3-BEHAvSCI-10-00114],[@b4-BeHaVsci-10-00114],[@b5-BehAVsci-10-00114],[@b6-BEhavsci-10-00... | 1. Introduction {#sec1-behavsci-10-00114} =============== Healthy parent--child interactions provide opportunities forchildren to accrue rich social experiences for development \[[@B1-behavsci-10-00114],[@B2-behavsci-10-00114],[@B3-behavsci-10-00114],[@B4-behavsci-10-00114],[@B5-behavsci-10-00114],[@B6-behavsci-10-00... | 1. Introduction {#sec1-behavsci-10-00114} =============== _Healthy_ parent--child interactions _provide_ opportunities _for_ children to accrue rich social _experiences_ for development \[[@B1-behavsci-10-00114],[@B2-behavsci-10-00114],[@B3-behavsci-10-00114],[@B4-behavsci-10-00114],[@B5-behavsci-10-00114],[@B6-behavsc... |
1. Introduction {#sec1-jfb-09-00008}
===============
Building an electronic device out of single molecules represents the ultimate miniaturization of active electronic components. Not only could such molecular-scale devices conceivably increase circuit density by thousands of folds compared to today's state of the art... | 1. introduction { # sec1 - 12 - 09 - 00008 } = = = = = = = = = = = = = = = building an electronic device out of single molecules represents the ultimate miniaturization of active electronic components. not only could such molecular - enabled devices conceivably increase circuit density by thousands of folds thanks to t... | 1. Introduction {# sec1 - jfb - 09 - 00008} = = = = = = = = = = = = = = = Building an electronic device out of single molecules represents the ultimate miniaturization of active electronic components. Not only could such molecular - scale devices conceivably increase circuit density by thousands of folds compared to to... | 1. Introduction {#sec1-jfb-09-00008} =============== Building an electronic device out of single molecules represents the ultimate miniaturization active electronic components. Not only could such molecular-scale devices conceivably increase circuit density by thousands folds compared today's state of the art silicon-b... | 1. InTRoDuctIOn {#sEc1-jfb-09-00008}
===============
buildinG AN eLEcTronIC dEvice OUT Of sInGLE MoLECules rEPreSENTS the UltiMAtE miNIAturIZAtiON OF acTiVE eLEcTrOnic cOMpONenTs. not oNLY CoUld sUCh MoLEcULAr-ScAlE deVICes cOnceiVABLY increasE cirCUIt dENsITY bY thOUSANDs Of fOLDs CoMPAred tO toDAy's stATe Of ThE art... | 1.Introduction {#sec1-jfb-09-00008} =============== Building an electronic device out of single molecules represents the ultimate miniaturization ofactive electronic components.Not only could such molecular-scale devices conceivably increase circuit density bythousandsof folds compared to today's state of thea... | 1. _Introduction_ {#sec1-jfb-09-00008} =============== Building an electronic device out of single _molecules_ represents the _ultimate_ miniaturization of active electronic _components._ _Not_ _only_ could such molecular-scale devices conceivably increase circuit density _by_ thousands of _folds_ _compared_ to today's... |
INTRODUCTION {#Sec1}
============
The potential influence of excipients on the performance of solid oral dosage forms is a topic of great interest in terms of pharmaceutical Quality by Design (QbD). Further to their intended use, excipients may affect the properties and performance of final dosage forms leading to bat... | introduction { # sec1 } = = = = = = = = = = = = the potential influence of excipients on the quality of solid oral dosage forms is a topic of great interest in terms of pharmaceutical quality by design ( qbd ). further to their intended use, excipients may compromise the properties and performance of final dosage forms... | INTRODUCTION {# Sec1} = = = = = = = = = = = = The potential influence of excipients on the performance of solid oral dosage forms is a topic of great interest in terms of pharmaceutical Quality by Design (QbD ). Further to their intended use, excipients may affect the properties and performance of final dosage forms le... | {#Sec1} ============ The potential influence of excipients the performance of solid oral dosage forms is a topic of great in terms of Quality Design (QbD). Further to their intended use, excipients may affect the properties performance of final dosage forms leading to batch inconsistencies, altered and bioinequivalence... | iNTRODUCTIon {#SEC1}
============
the poTEntIAl influencE oF ExcIpiEnTs ON THE PERfOrMANCe of SoLID oRaL DOSagE fORmS iS a TOPIC Of GREat INtEReSt in teRMs Of PharMaceuticAl quaLiTy BY DEsIgn (QbD). FurthER tO TheiR intENdeD USE, exCiPiEnTS maY AFFecT THE pRoPErtIES aND PErfOrMAnce OF FINAL dOSAGe FOrMS Leading tO BAT... | INTRODUCTION {#Sec1} ============ The potential influence of excipients on the performance of solid oral dosage forms isatopic of great interest in termsof pharmaceutical Quality by Design (QbD).Further to their intendeduse,excipients may affect the properties and performance of final dosage forms lead... | INTRODUCTION {#Sec1} ============ The potential influence of excipients on the performance _of_ solid oral dosage _forms_ is a topic of great interest in terms _of_ pharmaceutical _Quality_ by _Design_ _(QbD)._ Further to their intended use, excipients may affect the _properties_ and performance of final _dosage_ forms... |
Background {#Sec1}
==========
As a member of the nuclear receptor family, the androgen receptor (AR) plays an important role in breast cancer, and has been identified as a biomarker for a specific molecular subtype of breast cancer. The AR gene expression profile can be used for further classifying receptor-negative t... | background { # sec1 } = = = = = = = = = = as a member of the nuclear receptor family, the androgen receptor ( ar ) plays a important role in breast cancer, and has been identified as a biomarker for a specific molecular subtype of breast cancer. the ar gene expression profile can be used for further classifying recepto... | Background {# Sec1} = = = = = = = = = = As a member of the nuclear receptor family, the androgen receptor (AR) plays an important role in breast cancer, and has been identified as a biomarker for a specific molecular subtype of breast cancer. The AR gene expression profile can be used for further classifying receptor -... | Background {#Sec1} ========== As a member of the nuclear receptor family, the androgen receptor (AR) plays an important role in breast cancer, and has been identified a biomarker for a specific molecular subtype of breast cancer. The AR gene expression profile can be used for further classifying receptor-negative tumor... | bacKgRoUnd {#SEc1}
==========
AS a meMbEr Of the nUcLeAr rECEPTor fAmILy, thE ANDrOGEN ReCepToR (AR) plaYs aN imPorTAnt rOLE IN breaSt caNcEr, ANd has beEn IDentIFiED As A bIomArkeR FOr a SpeCIfIc MoleCuLaR Subtype of BreaST CanCER. The AR GENe eXPRessiON PrOfIlE caN Be uSed foR FurTHEr CLaSsIfyIng REcepToR-NEGaTiVE T... | Background {#Sec1}========== As a member of the nuclear receptor family, the androgen receptor (AR) plays an important role in breastcancer, and has beenidentified asabiomarker for aspecific molecular subtype of breastcancer. The AR gene expression profile canbe used for further classifying receptor-n... | Background {#Sec1} ========== As a member _of_ _the_ nuclear _receptor_ _family,_ the androgen receptor (AR) plays _an_ important _role_ _in_ breast _cancer,_ and has been _identified_ as a _biomarker_ _for_ a specific _molecular_ subtype of breast _cancer._ The AR gene expression _profile_ can be used _for_ further cl... |
Introduction {#s0001}
============
Rising healthcare costs and the quadruple burden of disease demand critical scrutiny of healthcare organisation and practice globally. It is estimated that by 2020 chronic diseases will account for 73% of all deaths and 60% of the global burden of disease.^[@CIT0001]^ The growing bur... | introduction { # s0001 } = = = = = = = = = = = = rising healthcare incidence and the quadruple burden of disease demand critical scrutiny of healthcare organisation and practice globally. it is estimated that by 2020 chronic diseases will account for 73 % of all deaths exceeding 60 % of the global burden of disease. ^ ... | Introduction {# s0001} = = = = = = = = = = = = Rising healthcare costs and the quadruple burden of disease demand critical scrutiny of healthcare organisation and practice globally. It is estimated that by 2020 chronic diseases will account for 73% of all deaths and 60% of the global burden of disease. ^ [@ CIT0001] ^ ... | Introduction {#s0001} ============ Rising healthcare costs and the disease demand critical scrutiny of healthcare organisation and practice globally. is estimated that by 2020 chronic diseases account 73% of all deaths and 60% of the global burden of disease.^[@CIT0001]^ The growing of chronic diseases is risking the s... | inTROductioN {#s0001}
============
RISiNG hEaltHcARe coSTs AnD THe QuadRupLe bURdEN of dISeaSE dEManD CrIticAL SCrutiNY Of HealTHCAre oRgAniSAtiOn aNd PrACtIce glObALly. It IS eStimaTED THAt BY 2020 chRoNIC diSeaSeS will aCcouNt FOR 73% OF All deaTHs anD 60% oF THE GlObaL BURdeN oF DIsEaSe.^[@cIt0001]^ THe GRoWiNG bUr... | Introduction {#s0001} ============ Rising healthcare costs and the quadruple burden of disease demandcritical scrutiny of healthcare organisationandpractice globally. It is estimated that by 2020 chronicdiseases will account for 73% of all deaths and 60% of the global burden of disease.^[@CIT0001]^... | _Introduction_ {#s0001} ============ Rising _healthcare_ costs and the quadruple burden _of_ disease demand _critical_ scrutiny of healthcare organisation and _practice_ globally. _It_ is estimated that by 2020 chronic diseases will account for 73% of all deaths and _60%_ of the global _burden_ of disease.^[@CIT0001]^ ... |
Introduction
============
Dietary guidance is consistent in recommending greater consumption of fruit and vegetables to promote health. Indeed, the 2015 Dietary Guidelines Advisory Committee report noted that greater fruit and vegetable intake was the only characteristic of dietary patterns that was consistently ident... | introduction = = = = = = = = = = = = dietary guidance is consistent in recommending greater consumption of fruit and vegetables to promote health. indeed, the 2015 dietary guidelines advisory committee report noted that greater fruit and vegetable intake was the only characteristic among dietary patterns that was consi... | Introduction = = = = = = = = = = = = Dietary guidance is consistent in recommending greater consumption of fruit and vegetables to promote health. Indeed, the 2015 Dietary Guidelines Advisory Committee report noted that greater fruit and vegetable intake was the only characteristic of dietary patterns that was consiste... | Introduction ============ Dietary is consistent in recommending greater of fruit vegetables health. the 2015 Dietary Guidelines Advisory Committee report noted greater fruit and vegetable intake was the characteristic of dietary patterns that was consistently identified their report in every conclusion across health ou... | INtROductIoN
============
DiETaRy GuIDance Is CONSIStENt iN reComMendiNg GreatEr CoNsumption Of FRUIT AND VegetABles To pROMOTe heALTH. InDEEd, THe 2015 DieTarY GuIDelinEs ADViSoRY cOMMitTee rePoRT Noted That GREAtER fRUiT and vEGeTABle INTake wAS THe only cHaRActerIsTIc Of DiETArY PAtterNS ThAT waS COnsistentLy ident... | Introduction ============ Dietary guidance is consistent in recommending greater consumptionof fruit and vegetablesto promote health. Indeed, the 2015 Dietary Guidelines Advisory Committee report noted that greater fruit and vegetable intake was the only characteristic of dietary patterns that was consisten... | Introduction _============_ Dietary guidance is consistent _in_ _recommending_ greater consumption of fruit and vegetables to promote health. Indeed, _the_ 2015 Dietary Guidelines Advisory Committee report noted that greater fruit and vegetable intake _was_ the only _characteristic_ of _dietary_ _patterns_ that was con... |
INTRODUCTION {#sec0005}
============
Cancers of the kidney and renal pelvis account for approximately 3.5% of all new cancer cases in the United States and are responsible for 3.9 deaths per 100,000 individuals per year. Most arise in the kidney, and are commonly described as renal cell carcinoma (RCC). The majority (... | introduction { # sec0005 } = = = = = = = = = = = = cancers of the kidney and distal pelvis account for almost 3. 1 % of all new cancer cases in the united states and are responsible for 3. 9 deaths per 100, 000 individuals per year. most arise in the kidney, and are commonly described as renal cell carcinoma ( rcc ). t... | INTRODUCTION {# sec0005} = = = = = = = = = = = = Cancers of the kidney and renal pelvis account for approximately 3. 5% of all new cancer cases in the United States and are responsible for 3. 9 deaths per 100, 000 individuals per year. Most arise in the kidney, and are commonly described as renal cell carcinoma (RCC ).... | INTRODUCTION {#sec0005} ============ Cancers of the kidney and renal pelvis account for approximately 3.5% of all new cancer cases in United States and are responsible for 3.9 deaths 100,000 individuals per year. Most arise in the kidney, are commonly described carcinoma (RCC). The majority (65%) of RCCs present as loc... | intROdUcTiOn {#sEC0005}
============
cancERs Of ThE KiDneY aND reNaL pELvis accoUNT FoR ApprOXimATeLy 3.5% Of All nEW CancEr cASeS In the UNitEd STATes AnD arE rEsponsiblE for 3.9 DeATHs PeR 100,000 IndIvidualS PeR YeAR. mosT ArISe IN the KIdNeY, aND aRe COMmONly DEsCribED aS ReNaL CELL CarCiNoMa (rCC). the MaJoritY (... | INTRODUCTION {#sec0005} ============Cancers of the kidney and renal pelvis account for approximately 3.5% of all new cancer cases in theUnitedStates and are responsible for 3.9 deaths per 100,000 individuals peryear.Most arise in the kidney, and are commonly described as renal cell carcinoma (RCC). The majority (6... | INTRODUCTION {#sec0005} ============ _Cancers_ of the _kidney_ and _renal_ pelvis account for approximately 3.5% of all new _cancer_ cases in _the_ United States and are responsible for 3.9 _deaths_ per 100,000 individuals per year. Most arise in the _kidney,_ and are commonly _described_ as renal cell carcinoma (RCC).... |
Introduction {#Sec1}
============
Taxol is a diterpenoid natural product, had been originally isolated and chemically identified from the bark of Pacific yew *Taxus brevifolia*^[@CR1]^. It has been approved by FDA in 1992 as a broad-spectrum drug for treatment of refractory ovarian, breast, melanoma, pancreatic and lu... | introduction { # sec1 } = = = = = = = = = = = = taxol is a diterpenoid natural product, had been originally isolated and chemically identified from the bark of pacific yew * taxus brevifolia * ^ [ @ cr1 ] ^. it has been approved by fda in 1992 as a broad - spectrum drug for treatment of refractory ovarian, breast, mela... | Introduction {# Sec1} = = = = = = = = = = = = Taxol is a diterpenoid natural product, had been originally isolated and chemically identified from the bark of Pacific yew * Taxus brevifolia * ^ [@ CR1] ^. It has been approved by FDA in 1992 as a broad - spectrum drug for treatment of refractory ovarian, breast, melanoma... | Introduction {#Sec1} ============ Taxol is a diterpenoid natural product, had been originally isolated and chemically identified from the bark of Pacific *Taxus brevifolia*^[@CR1]^. It has been by FDA in 1992 as a broad-spectrum drug for treatment of refractory ovarian, breast, melanoma, pancreatic and lung The antican... | inTRODuCtiON {#SEc1}
============
taxOL Is a DITeRPeNoID NatURal pRODuCT, hAd been oriGINalLY ISolAted AnD CHemICALLy iDentIFIEd fRom tHe BaRk of pAcIfIC yeW *tAXUs breVifoLia*^[@cR1]^. It HAS bEen approVED By Fda iN 1992 As a BrOAd-SPEctruM drUG FOR trEatmeNt oF REfracTory oVARIan, bREasT, melANoMa, pANCREaTic anD LU... | Introduction {#Sec1} ============ Taxol is a diterpenoid natural product, had beenoriginally isolated and chemically identified from the bark of Pacific yew *Taxus brevifolia*^[@CR1]^. It has been approved byFDA in 1992 as a broad-spectrum drug for treatment of refractory ovarian, breast, melanoma, p... | _Introduction_ {#Sec1} ============ _Taxol_ is a diterpenoid natural product, _had_ been _originally_ isolated and _chemically_ identified from the _bark_ _of_ Pacific yew *Taxus brevifolia*^[@CR1]^. It has been _approved_ _by_ FDA in 1992 as a _broad-spectrum_ drug for treatment of refractory _ovarian,_ _breast,_ mela... |
Background
==========
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in several brain diseases as a detrimental factor playing a causal or exacerbating role in neuroinflammation and neurodegeneration \[[@B1]-[@B7]\]. Elevated levels of IL-6 are typical for brains from animal models or humans suffering from mu... | background = = = = = = = = = = interleukin - 1 ( il - 6 ) is a pleiotropic cytokine involved in several brain diseases as one detrimental factor playing a causal or exacerbating role in neuroinflammation and neurodegeneration \ [ [ @ b1 ] - [ @ b7 ] \ ]. elevated levels of il - 6 is typical for brains from animal model... | Background = = = = = = = = = = Interleukin - 6 (IL - 6) is a pleiotropic cytokine involved in several brain diseases as a detrimental factor playing a causal or exacerbating role in neuroinflammation and neurodegeneration \ [[ @ B1] - [@ B7] \ ]. Elevated levels of IL - 6 are typical for brains from animal models or hu... | Background ========== Interleukin-6 (IL-6) is a pleiotropic cytokine involved in several brain diseases as a detrimental factor playing or exacerbating role in neuroinflammation and neurodegeneration \[[@B1]-[@B7]\]. Elevated levels of IL-6 are typical for brains animal models or humans suffering multiple Alzheimer\'s ... | BACKGROUnd
==========
iNTeRLeukiN-6 (il-6) Is A PleIotrOPic CYTOkine InVOlVED IN seVErAl BRAin DISeasES as A DETRIMENTAL FACTor plaYiNG a cAuSAl oR ExAcERBAtING role IN NeUroINFlAmmaTIoN ANd NeUrODegenERatioN \[[@b1]-[@B7]\]. ElEVAted lEVeLs oF IL-6 aRe tyPical FoR bRAINs FRom aniMAl MODElS oR HUManS SufFErING frOM mu... | Background ========== Interleukin-6(IL-6) is a pleiotropic cytokine involvedinseveralbrain diseases as a detrimental factor playing acausal or exacerbating rolein neuroinflammation and neurodegeneration \[[@B1]-[@B7]\]. Elevated levels ofIL-6 are typical for brains from animal models or humans suffering ... | Background _==========_ _Interleukin-6_ _(IL-6)_ _is_ a pleiotropic cytokine involved in several _brain_ diseases _as_ a _detrimental_ factor playing _a_ causal _or_ exacerbating role in neuroinflammation and neurodegeneration \[[@B1]-[@B7]\]. Elevated levels of _IL-6_ are typical for brains _from_ animal models or hum... |
1. Introduction {#s0005}
===============
All live cells have a stable transmembrane potential (TMP) voltage differential across the cell membrane when the cell is at rest. This is the result of the accumulated ion concentrations within the cell compared to that outside the membrane. Electrically active cells, such as ... | 1. introduction { # s0005 } = = = = = = = = = = = = = = = 4 live cells have a stable transmembrane potential ( tmp ) voltage differential across the cell membrane when the cell is at rest. this is the result of the accumulated ion concentration within the cell compared to that outside the membrane. electrically active ... | 1. Introduction {# s0005} = = = = = = = = = = = = = = = All live cells have a stable transmembrane potential (TMP) voltage differential across the cell membrane when the cell is at rest. This is the result of the accumulated ion concentrations within the cell compared to that outside the membrane. Electrically active c... | Introduction {#s0005} =============== All live cells have stable transmembrane potential (TMP) voltage differential across the cell membrane when cell is at rest. This is the result of the accumulated ion concentrations within the cell compared to that outside the membrane. Electrically active cells, such neurons, musc... | 1. INTrODUCTIon {#s0005}
===============
ALL liVE CELls hAve A staBle TRANSmeMbrane PoTentIaL (Tmp) vOLtAge DIfFeREntIAL AcroSs the cELL MemBRAnE WHEn the cEll iS at REst. this iS ThE RESuLT OF thE ACCUmulAtED IoN COncEnTRATionS wiThin ThE Cell CoMPAReD tO THaT ouTsiDE thE mEmbRaNE. eLECTriCAllY activE CELlS, sUCH AS ... | 1. Introduction {#s0005} =============== All live cells have a stable transmembranepotential (TMP) voltage differential across the cell membrane when the cell is at rest. This is the result of the accumulated ion concentrations within the cellcomparedto thatoutside the membrane. Electrically activecells,such ... | 1. Introduction {#s0005} =============== All live cells have a stable transmembrane potential _(TMP)_ _voltage_ _differential_ across the cell membrane when the cell is at _rest._ This is the result of the accumulated ion concentrations within the _cell_ compared _to_ that outside the _membrane._ Electrically active _c... |
All data are hosted by the Harvard Dataverse (<https://dataverse.harvard.edu/dataset.xhtml?persistentId=doi:10.7910/DVN/HZDQ70>). Data are also hosted at IRRI (<http://ricestat.irri.org/fhsd/php/survey.php>) under Project ID: 98.
Introduction {#sec001}
============
Rice *(Oryza sativa* L.*)* is one of the most import... | all data are hosted by the harvard dataverse ( < https : / / dataverse. harvard. edu / dataset. xhtml? persistentid = doi : 10. 7910 / dvn / hzdq70 > ). data are also hosted at irri ( < http : / / ricestat. irri. org / fhsd / php / survey. php > ) under project doi : 98. introduction { # sec001 } = = = = = = = = = = = ... | All data are hosted by the Harvard Dataverse (< https: / / dataverse. harvard. edu / dataset. xhtml? persistentId = doi: 10. 7910 / DVN / HZDQ70> ). Data are also hosted at IRRI (< http: / / ricestat. irri. org / fhsd / php / survey. php> ) under Project ID: 98. Introduction {# sec001} = = = = = = = = = = = = Rice * (O... | All are hosted by the Harvard (<https://dataverse.harvard.edu/dataset.xhtml?persistentId=doi:10.7910/DVN/HZDQ70>). are also hosted at IRRI (<http://ricestat.irri.org/fhsd/php/survey.php>) under Project ID: 98. Introduction {#sec001} ============ Rice *(Oryza sativa* L.*)* is one of the most important food crops as it i... | ALl daTA are HoSTed By tHE HarVArd dAtaverSE (<HTtpS://datAVErSe.HARVaRD.edu/dAtaseT.XhtML?persISteNtid=DOi:10.7910/DvN/hzDQ70>). dAta ARe ALso HOSTed AT irrI (<HttP://rIcesTAT.irRi.ORG/fHsD/Php/sUrVey.PhP>) uNDer PROjecT id: 98.
inTRodUCtION {#sEC001}
============
RiCe *(ORyza SatIva* L.*)* is OnE OF thE mOSt IMPorT... | All data arehosted by the Harvard Dataverse(<https://dataverse.harvard.edu/dataset.xhtml?persistentId=doi:10.7910/DVN/HZDQ70>). Data are alsohosted at IRRI (<http://ricestat.irri.org/fhsd/php/survey.php>) underProject ID: 98. Introduction {#sec001} ============ Rice *(Oryza sativa*L.*)* is one of themost im... | All data are hosted by the Harvard Dataverse (<https://dataverse.harvard.edu/dataset.xhtml?persistentId=doi:10.7910/DVN/HZDQ70>). Data are also hosted at _IRRI_ (<http://ricestat.irri.org/fhsd/php/survey.php>) _under_ Project ID: 98. Introduction {#sec001} ============ _Rice_ *(Oryza sativa* L.*)* is one of the _most_ ... |
All relevant data are within the manuscript and its Supporting Information files.
Introduction {#sec001}
============
Nest site selection is a key component of successful breeding in seabirds \[[@pone.0212668.ref001]\]. Optimal conditions at a breeding site are shaped by multiple factors, including both abiotic and b... | all relevant data are within the manuscript and its supporting information files. introduction { # sec001 } = = = = = = = = = = = = nest site selection is key key component of successful breeding in seabirds \ [ [ @ pone. 0212668. ref001 ] \ ]. optimal conditions at a breeding site were shaped by multiple factors, incl... | All relevant data are within the manuscript and its Supporting Information files. Introduction {# sec001} = = = = = = = = = = = = Nest site selection is a key component of successful breeding in seabirds \ [[ @ pone. 0212668. ref001] \ ]. Optimal conditions at a breeding site are shaped by multiple factors, including b... | relevant data are within the and its Supporting Information files. Introduction {#sec001} ============ Nest site selection is key component of successful breeding in seabirds \[[@pone.0212668.ref001]\]. Optimal at a breeding site are by multiple factors, including both abiotic and biotic components as well as their int... | AlL relEvANt DAtA Are wItHin The mANUsCrIpT AND ItS sUpportING INfORmAtION FiLeS.
INtRoDUCtioN {#sEc001}
============
NEST SitE sELEction IS a KEy cOmponenT oF sUcCEssfUl breedINg In sEabIRdS \[[@ponE.0212668.reF001]\]. optiMaL cOnDITioNS aT a BrEEdiNG Site arE sHaPEd By mUlTIpLE fActoRS, iNCLUdING BoTh abioTIc ANd b... | All relevant data are within the manuscript and its Supporting Informationfiles. Introduction {#sec001} ============ Nest site selection isa key component of successfulbreeding in seabirds \[[@pone.0212668.ref001]\]. Optimal conditions at abreeding site are shaped by multiple factors, including bothabiotic... | All relevant data _are_ within the manuscript _and_ its Supporting Information files. _Introduction_ {#sec001} ============ Nest site selection is _a_ _key_ _component_ of _successful_ breeding in _seabirds_ \[[@pone.0212668.ref001]\]. _Optimal_ conditions at _a_ breeding site are _shaped_ by multiple factors, includin... |
INTRODUCTION
============
Rhabdomyolysis is the breakdown of skeletal muscle that can rapidly progress to acute renal failure or death. It is important to make a rapid diagnosis and initiate treatment for rhabdomyolysis in order to decrease morbidity and mortality. To date there are no reports in the emergency medicin... | introduction = = = = = = = = = = = = rhabdomyolysis is the breakdown of skeletal muscle that can rapidly progress to acute renal failure or death. it is important to make a rapid diagnosis and initiate treatment for rhabdomyolysis in order to decrease morbidity and mortality. to date there are no reports in the emergen... | INTRODUCTION = = = = = = = = = = = = Rhabdomyolysis is the breakdown of skeletal muscle that can rapidly progress to acute renal failure or death. It is important to make a rapid diagnosis and initiate treatment for rhabdomyolysis in order to decrease morbidity and mortality. To date there are no reports in the emergen... | INTRODUCTION ============ Rhabdomyolysis the breakdown of skeletal muscle that can rapidly progress to acute renal failure or death. It is important to make a diagnosis initiate treatment for rhabdomyolysis order to decrease morbidity and mortality. To date there are no reports in the emergency literature on the use of... | IntRODuctioN
============
RHaBdOMyOLYSIS iS tHE bReAkdOWN Of skeLetaL MuSCle That CAN RapIDly PRogREss to ACute RENAL fAiLUre oR DEatH. iT IS iMPoRTant TO MaKE A RaPId dIaGNOSiS aNd iNItIaTe tReATmENT FOR RHAbdOmyOlysIS in oRDeR To DeCREaSE morbiditY aND MORtALIty. tO DaTe THeRE ARe NO rEPorTS IN THE eMergeNCy mEDIciN... | INTRODUCTION ============Rhabdomyolysis is the breakdown of skeletal muscle thatcan rapidly progressto acute renal failure or death. It is important to make a rapid diagnosisand initiate treatment for rhabdomyolysis in order to decrease morbidity and mortality. To date there are no reports inthe emer... | _INTRODUCTION_ ============ Rhabdomyolysis _is_ the _breakdown_ of skeletal muscle _that_ _can_ _rapidly_ progress to _acute_ _renal_ failure _or_ death. It is _important_ to make a rapid diagnosis and initiate treatment for rhabdomyolysis in order to _decrease_ morbidity and mortality. _To_ date _there_ are _no_ repor... |
INTRODUCTION {#sec1-1}
============
L-carnitine is an essential factor for the membrane transport of acyl-CoA compounds, particularly for the intramitochondrial transport of long-chain fatty acids \[[@ref1]\]. L-carnitine also helps to remove by-products of fatty acid metabolism and other toxic compounds from the cell... | introduction { # sec1 - 1 } = = = = = = = = = = = = l - carnitine is an essential factor for the membrane transport of acyl - coa compounds, particularly for the intramitochondrial transport of long - chain fatty acids \ [ [ @ ref1 ] \ ]. l - carnitine also helps to remove by - products of fatty acid metabolism to meta... | INTRODUCTION {# sec1 - 1} = = = = = = = = = = = = L - carnitine is an essential factor for the membrane transport of acyl - CoA compounds, particularly for the intramitochondrial transport of long - chain fatty acids \ [[ @ ref1] \ ]. L - carnitine also helps to remove by - products of fatty acid metabolism and other t... | INTRODUCTION {#sec1-1} ============ L-carnitine is an essential factor for the membrane transport of compounds, particularly for the intramitochondrial transport of long-chain fatty acids \[[@ref1]\]. L-carnitine also helps to remove by-products of acid metabolism and other toxic compounds from the cells \[[@ref2]\]. T... | inTrODUCTION {#SeC1-1}
============
l-CArnItine iS an ESSeNTIAl factOr FOr tHe mEMBranE TranSPoRt oF acyl-COa comPOunds, PaRTIcuLARlY fOR the iNtraMiTOChONdRial TrANspoRt Of LOng-cHAin fAtty ACIdS \[[@rEf1]\]. l-CARnITINe Also helpS TO RemOvE BY-ProDuctS oF FatTY aciD MetabolISm And Other toxIc coMpoUNdS FroM The cELL... | INTRODUCTION {#sec1-1} ============ L-carnitine is an essential factor for the membrane transportof acyl-CoA compounds, particularly for the intramitochondrial transport of long-chain fatty acids \[[@ref1]\]. L-carnitine also helps toremove by-products of fatty acid metabolism and other toxic compou... | INTRODUCTION _{#sec1-1}_ ============ L-carnitine is an _essential_ factor for the membrane transport of acyl-CoA compounds, particularly for the intramitochondrial transport of long-chain _fatty_ acids \[[@ref1]\]. L-carnitine also helps to remove by-products _of_ fatty _acid_ metabolism and other toxic compounds from... |
1. Introduction {#sec1-biosensors-10-00039}
===============
Capillary-driven flow microfluidics is a type of microfluidics which allows fluid movements into microchannels via capillary forces and does not require internal/external expensive and complicated fluid management mechanisms \[[@B1-biosensors-10-00039]\]. Thi... | 1. introduction { # sec1 - biosensors - 10 - 00039 } = = = = = = = = = = = = = = = capillary - driven flow microfluidics is a type of microfluidics which allows fluid movements into microchannels via capillary forces and does not require internal / external expensive and complicated fluid management mechanisms \ [ [ @ ... | 1. Introduction {# sec1 - biosensors - 10 - 00039} = = = = = = = = = = = = = = = Capillary - driven flow microfluidics is a type of microfluidics which allows fluid movements into microchannels via capillary forces and does not require in4ernsl / external expensive and complicated fluid management mechanisms \ [[ @ B1 ... | 1. Introduction {#sec1-biosensors-10-00039} =============== Capillary-driven flow microfluidics is a type of microfluidics which allows movements into microchannels via capillary forces and not require expensive and complicated fluid management This of microfluidics has the potential to provide rapid, inexpensive and s... | 1. iNTRodUCTION {#SEc1-BiOSENsORS-10-00039}
===============
CApILLARY-Driven FlOw MIcROfLUIdiCS iS A type oF MicrOfluIDiCs whiCh alLoWs flUiD mOVeMenTS iNto miCRocHannElS Via cApIllaRY fOrCes and dOEs Not REQUIRE intERnAL/EXTErNal eXpeNsivE and cOmPLICated flUiD mANaGemEnT mechANIsmS \[[@B1-BIoseNSOrs-10-00039]\]. tHI... | 1. Introduction {#sec1-biosensors-10-00039}=============== Capillary-driven flow microfluidics is a typeof microfluidics whichallows fluid movements into microchannelsvia capillary forces and does not require internal/external expensive and complicated fluid management mechanisms \[[@B1-biosensors-10-0003... | 1. Introduction {#sec1-biosensors-10-00039} =============== Capillary-driven _flow_ microfluidics is a _type_ of microfluidics which allows fluid movements _into_ microchannels via _capillary_ forces and does not _require_ internal/external expensive and complicated fluid management _mechanisms_ \[[@B1-biosensors-10-00... |
Background {#s1}
==========
Developing a drug from first-in-human studies to Food and Drug Administration (FDA) approval is a lengthy and costly process ([@CIT0006]). In an effort to streamline therapeutic development, recent efforts have sought to repurpose clinically-available drugs by detecting heretofore unrecogni... | because { # s1 } = = = = = = = = = = developing a drug from first - in - human studies to food and drug administration ( dea ) approval is a lengthy and costly process ( [ @ cit0006 ] ). in an effort to boost therapeutic development, recent efforts have sought to repurpose clinically - available drugs by detecting here... | Background {# s1} = = = = = = = = = = Developing a drug from first - in - human studies to Food and Drug Administration (FDA) approval is a lengthy and costly process ([ @ CIT0006] ). In an effort to streamline therapeutic development, recent efforts have sought to re96rpose clinically - available drugs by detecting he... | {#s1} ========== Developing a drug from first-in-human studies to Food and (FDA) approval is a and costly process ([@CIT0006]). In an effort to streamline therapeutic development, recent efforts have to repurpose clinically-available drugs by detecting heretofore unrecognized or off-target effects. Psychiatry is replet... | BAckgROund {#s1}
==========
DEVElopiNG A DruG FrOM fIrsT-In-hUmAN sTUdIEs To FoOD And DRUg adMINisTRAtion (FDA) AppROVAL is A LeNgthy AND COsTlY ProCEss ([@ciT0006]). IN An eFFort TO sTREAmlIne theRapEUTic dEVeLOPMenT, recENt EFFOrts havE sOUGHt TO REpURpoSE CLInicaLLy-aVaIlablE DRUGs by DEtecTING HeretoforE uNrecOgnI... | Background {#s1} ========== Developinga drug from first-in-human studiesto Food and Drug Administration (FDA) approval is a lengthy and costly process ([@CIT0006]). Inan effort to streamline therapeutic development, recent efforts havesought to repurpose clinically-available drugs by detectingheretofore unrecog... | Background _{#s1}_ ========== Developing a drug from _first-in-human_ studies to Food and Drug Administration (FDA) approval is a lengthy and costly process ([@CIT0006]). In _an_ _effort_ to _streamline_ therapeutic development, recent _efforts_ have sought to repurpose clinically-available drugs by _detecting_ heretof... |
Erratum to: Clin Transl Oncol (2015) 17:996--1004 DOI 10.1007/s12094-015-1456-y {#Sec1}
===============================================================================
The affiliation of the author A. Custodio was rendered wrongly. The correct affiliation is: Medical Oncology Department, Hospital Universitario La Paz,... | erratum to : clin vascular oncol ( 2015 ) 17 : 996 - - 1004 doi 10. 04 / s12094 - 015 - 1456 - y { # sec1 } = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = the affiliation of the author a. martinez moreno rende... | 2rrXtum to: Clin Transl Pnc0l (2015) 17: 996 - - q00$ DOI 10. W00y / s12094 - 015 - 1r5Y - y {# Sec1} = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = The affiliation of the author A. Cuc^odio was rendered wrong... | Erratum to: Clin Transl Oncol (2015) 17:996--1004 DOI 10.1007/s12094-015-1456-y {#Sec1} The affiliation of the author A. Custodio was rendered wrongly. The affiliation is: Medical Oncology Department, Hospital Universitario La Madrid, Spain. The authors regret this error and apologize for any caused. The online version... | ERRatum tO: CLIn traNSl OnCol (2015) 17:996--1004 DoI 10.1007/s12094-015-1456-Y {#sEc1}
===============================================================================
the AFFilIATION oF ThE AUthoR a. cUsTODIO was rEnDErEd wRoNGLY. ThE cOrREcT AfFilIAtION IS: MedICaL oncoLoGY dEPARTMEnt, hOSPItAl uNIVersitaRIO lA paZ,... | Erratum to: Clin Transl Oncol (2015) 17:996--1004 DOI 10.1007/s12094-015-1456-y {#Sec1} =============================================================================== Theaffiliation of the author A.Custodio was rendered wrongly. The correct affiliation is: Medical Oncology Department, Hospital Univer... | Erratum to: Clin Transl Oncol (2015) _17:996--1004_ DOI 10.1007/s12094-015-1456-y {#Sec1} =============================================================================== The affiliation of the author A. Custodio was _rendered_ wrongly. The correct _affiliation_ is: _Medical_ Oncology _Department,_ Hospital _Universitar... |
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{#sp2 .289}
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{#sP2 .289}
| {#sp1 .288} {#sp2 .289} | {#sp1 _.288}_ {#sp2 _.289}_ |
Introduction {#Sec1}
============
Excessive use of antibiotics in general and in veterinary medicine has resulted in the contamination of the natural environment with these substances (EEA [@CR20]). Of all the veterinary antibiotics (VAs), only 20% are used to treat infections; the other 80% are used to prevent diseas... | introduction { # sec1 } = = = = = = = = = = = = excessive use of antibiotics in general and in indoor medicine has resulted in the contamination of the natural environment with these substances ( eea [ @ cr20 ] ). of both the veterinary antibiotics ( vas ), only 20 % are used to treat infections ; the other 80 % are us... | Introduction {# Sec1} = = = = = = = = = = = = Excessive use of antibiotics in general and in veterinary medicine has resulted in the contamination of the natural environment with these substances (EEA [@ CR20] ). Of all the veterinary antibiotics (VAs ), only 20% are used to treat infections; the other 80% are used to ... | Introduction {#Sec1} ============ Excessive use of antibiotics in general in veterinary medicine has in the contamination of the natural environment with these substances (EEA [@CR20]). Of all the veterinary antibiotics (VAs), only used to treat infections; the other 80% are used to prevent diseases or to promote anima... | iNTRODuctiOn {#sEc1}
============
ExCeSSIve uSe OF anTIbiOTIcS IN gEneral anD iN VETerINary meDicINE Has rEsULted in tHe CoNtAmINaTiON OF the NatUraL envIRonMENt WITH tHEse SUBsTanceS (eea [@CR20]). OF All tHE VeteRInary ANtIbIoTIcs (VAS), only 20% aRE used TO TREAT inFectionS; tHe OTHeR 80% ARE UseD to prEveNt Diseas... | Introduction {#Sec1} ============ Excessive use ofantibiotics in general and in veterinary medicine has resulted in the contamination of the naturalenvironment with these substances (EEA [@CR20]). Of all the veterinary antibiotics (VAs),only20% areused totreat infections; the other 80% are used to pr... | Introduction {#Sec1} _============_ Excessive use of antibiotics in general and in veterinary medicine has _resulted_ in the contamination of the natural environment with _these_ substances _(EEA_ [@CR20]). Of all the veterinary antibiotics _(VAs),_ _only_ 20% are used to treat _infections;_ the other 80% are used to p... |
Overview of cancers
===================
Bladder cancer
--------------
Bladder cancer refers to any of several types of malignant growths of the urinary bladder, about 90--95% of which are transitional cell carcinomas (TCC); the remaining are squamous cell carcinomas and adenocarcinomas ([@bib50]). Every year in the U... | overview of cancers = = = = = = = = = = = = = = = = = = = bladder cancer - - - - - - - - - - - - - - bladder cancer refers to any of several types of malignant growths of the urinary bladder, about 90 - - 95 % of which are hairy cell carcinomas ( tcc ) ; the remaining are squamous cell carcinomas and adenocarcinomas ( ... | Overview of cancers = = = = = = = = = = = = = = = = = = = Bladder cancer - - - - - - - - - - - - - - Bladder cancer refers to any of several types of malignant growths of the urinary bladder, about 90 - - 95% of which are transitional cell carcinomas (TCC ); the remaining are squamous cell carcinomas and adenocarcinoma... | Overview of cancers =================== Bladder cancer -------------- Bladder cancer refers to any several types of malignant growths of the urinary bladder, about 90--95% of which are transitional cell (TCC); the remaining are squamous cell carcinomas and adenocarcinomas ([@bib50]). Every year the United Kingdom almos... | OVErView of CaNCeRS
===================
blAdder cANceR
--------------
BlaDdeR canCER rEferS TO aNy of seVeRal TYPES Of mALiGnAnt gROwthS Of thE uRinARy bLAddeR, about 90--95% of WhICH arE Transitional cell CarCInoMAS (TCC); THe ReMAIninG arE SQUaMoUS CEll carcINOmas aND adeNOCARCinomAs ([@BIb50]). eVEry YeaR In THE U... | Overview of cancers =================== Bladdercancer-------------- Bladder cancer refers to any of several types of malignantgrowths of the urinary bladder, about 90--95% of which are transitional cell carcinomas (TCC); theremaining are squamous cellcarcinomas and adenocarcinomas ([@bi... | Overview of cancers =================== Bladder cancer -------------- Bladder cancer refers to any of _several_ types _of_ malignant _growths_ of the urinary bladder, about _90--95%_ of which are transitional cell carcinomas (TCC); the remaining _are_ squamous cell carcinomas and adenocarcinomas _([@bib50])._ Every yea... |
The authors confirm that all data underlying the findings are fully available without restriction. Raw data are not suitable for public deposition as they contain identifying human information. Data are available upon request from the corresponding author.
Introduction {#s1}
============
In Western countries multiple... | the authors confirm that all materials underlying the findings are fully available without restriction. raw data are not suitable for public deposition as they contain identifying human information. data are available as request from the corresponding author. introduction { # s1 } = = = = = = = = = = = = in western cou... | The authors confirm that all data underlying the findings are fu;>y available without restriction. Raw data are not suitable for public deposition as they contain identifying human information. Data are available upon request from the corresponding author. Introduction {# s1} = = = = = = = = = = = = In Western countrie... | The authors confirm data underlying the findings are fully available without restriction. Raw data are not suitable for public deposition as they contain identifying human information. Data are available upon request the corresponding author. Introduction {#s1} In Western countries multiple sclerosis (MS) is second onl... | tHe aUthOrs cONFirm that All datA UndeRLYINg the fiNdingS aRe fULLY AvaIlABlE wiThoUt rESTRICtIOn. RAW DaTA ArE NoT suitabLe foR pUBLIc DEPoSITIon As THEY COntAin ideNTIFYINg humaN InfORMAtIon. dATA aRE AVaIlable uPoN reQuEst FROm The CORReSpOnDiNg authOR.
InTRODuCTIOn {#S1}
============
iN wesTErn COUNTrieS MUltIPLe... | The authors confirm that all data underlying the findings are fully available without restriction. Raw data arenot suitable for public deposition as they contain identifying human information. Data areavailable upon request from the corresponding author.Introduction {#s1} ============In Westerncountries mult... | _The_ authors confirm that all data underlying _the_ findings _are_ fully _available_ without restriction. Raw data _are_ not suitable _for_ public deposition _as_ they contain _identifying_ _human_ information. _Data_ are _available_ _upon_ request from the corresponding author. Introduction {#s1} ============ _In_ _W... |
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/anae.15220
| this article has been accepted for publication since undergone full peer review but has repeatedly been through the copyediting, typesetting, pagination and proofreading process, which may reflect confusing differences between this version and prior version referenced codex. please cite this article as doi : 10. 1111 /... | This article has been accepted for publJsation and undergone full peer reGidw but has not been th$ouYh the copyediting, typesetting, pagination and proofreavJng Lrovess, which may lead to differences be5eeen this ve$siin and the Version of Rwcorw. Please cite this artLcl# as doi: 10. 1111 / QGae. 15220 | This article has been accepted for publication undergone full peer review but has not been through the copyediting, typesetting, and proofreading which may lead to differences between this and the Version of Record. Please cite this article as doi:10.1111/anae.15220 | ThiS ArtICLe HAS BeEn acCEpted fOr puBlIcaTiON ANd UnDerGoNE FULL PEeR ReView bUT HaS NoT Been THROuGh the COpyEDitINg, TyPesETtInG, PAGinATiOn ANd pROOFREadiNg pRocESS, WHicH maY Lead tO DiffErEnCes beTweEN thIS VErSIon and THe VersiON of REcorD. PlEasE cITe tHiS aRtIcLE As dOI:10.1111/ANAE.15220
| This article has been accepted for publication and undergone full peer review buthas not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differencesbetween this version and theVersion of Record.Please cite this article as doi:10.1111/anae.15220 | This article has been _accepted_ for publication _and_ undergone _full_ _peer_ review but has not _been_ through the copyediting, typesetting, pagination and proofreading process, which may lead _to_ differences between this version _and_ the _Version_ of Record. Please cite this _article_ as _doi:10.1111/anae.15220_ |
Introduction {#sec1-1}
============
Ununited fractures of clavicle are occasionally seen in adults, but are rarely found in children\[[@ref1][@ref2]\]. Post-traumatic non-union of the clavicle is a rare complication in adulthood with a frequency of about 1%. This condition is also exceptional in children, despite the ... | introduction { # sec1 - 1 } = = = = = = = = = = = = ununited fractures each clavicle are occasionally seen in adults, but are often found in children \ [ [ @ ref1 ] [ @ ref2 ] \ ]. post - traumatic non - union of the clavicle is a rare complication in adulthood with a frequency of about 1 %. this condition is also exce... | Introduction {# sec1 - 1} = = = = = = = = = = = = Ununited fractures of clavicle are occasionally seen in adults, but are rarely found in children \ [[ @ ref1] [@ ref2] \ ]. Post - traumatic non - union of the clavicle is a rare complication in adulthood with a frequency of about 1% . This condition is also exceptional... | {#sec1-1} ============ Ununited fractures of clavicle are occasionally seen in adults, but are rarely found in children\[[@ref1][@ref2]\]. Post-traumatic non-union of the clavicle rare in adulthood with a frequency of about 1%. This condition also exceptional in children, despite the frequency of fracture at any given ... | INtrOduCtIoN {#sEc1-1}
============
UNUniTEd FractUREs OF clAvICle aRE ocCasIonaLLY seEn IN adULts, BuT are RaRElY fOuNd iN ChildreN\[[@REF1][@reF2]\]. posT-TRAUMAtic nOn-UNioN oF thE CLaVIcLe IS a raRe COMpLIcATiOn In aDULTHOod wITh a FreQuenCY of aBOUt 1%. tHIs cOndItioN IS aLso exCEpTIONAl IN ChIldRen, DESPIte tHE ... | Introduction {#sec1-1} ============ Ununited fracturesof clavicle are occasionally seen in adults, but arerarely found inchildren\[[@ref1][@ref2]\]. Post-traumatic non-union of the clavicle is a rare complication in adulthood with a frequency of about 1%.This condition is also exceptional in children, ... | _Introduction_ {#sec1-1} ============ Ununited fractures of clavicle are occasionally seen _in_ adults, but are rarely found _in_ children\[[@ref1][@ref2]\]. _Post-traumatic_ _non-union_ of the clavicle is a rare complication in adulthood _with_ a frequency _of_ _about_ _1%._ This _condition_ is also exceptional in chi... |
Introduction {#s1}
============
Microbial biomass in marine sediments accounts for 0.18−3.6% of Earth's total biomass (4.1 petagram carbon), and their community composition is highly diverse due to variation in oxygen concentrations in the overlying water, sediment carbon content, and sediment depth [@pone.0096219-Kal... | introduction { # s1 } = = = = = = = = = = = = microbial biomass in marine sediments accounts for 0. 18−3. 6 % of earth ' s total biomass ( 4. 06 petagram carbon ), and their community composition is highly diverse due upon variation in oxygen concentrations in the overlying water, sediment carbon content, and sediment ... | Introduction {# s1} = = = = = = = = = = = = Microbial biomass in marine sediments accounts for 0. 18 − 3. 6% of Earth ' s total biomass (4. 1 petagram carbon ), and their community composition is highly diverse due to variation in oxygen concentrations in the overlying water, sediment carbon content, and sediment depth... | Introduction ============ Microbial biomass in sediments accounts for 0.18−3.6% of Earth's total biomass (4.1 petagram carbon), and their community composition is diverse due to variation in oxygen concentrations in the overlying water, sediment content, and sediment depth [@pone.0096219-Kallmeyer1], [@pone.0096219-Orc... | InTroDUCTiOn {#s1}
============
mIcroBiAL biOMASs IN mARiNe SEdiMents accOUNTs for 0.18−3.6% oF eARth'S toTAL BioMASs (4.1 pEtagrAm CArboN), aND TheIR coMMuniTY COmPosItIoN IS highLY DIVERSE DUE To VariaTION iN OXYGEN CONcENtRaTIoNs iN the oVErLYING Water, SedImeNt CaRbon coNtent, AND sEDIMEnt DEpth [@POne.0096219-kAl... | Introduction {#s1} ============Microbialbiomass in marine sedimentsaccounts for 0.18−3.6% of Earth's total biomass (4.1 petagram carbon), and their community compositionis highlydiverse due tovariationin oxygen concentrations in the overlying water, sediment carboncontent, andsedimentdepth [@pone.0096219... | Introduction {#s1} ============ Microbial biomass in _marine_ sediments accounts for _0.18−3.6%_ of Earth's _total_ biomass (4.1 petagram carbon), _and_ their community composition is highly diverse due to variation in _oxygen_ concentrations in the _overlying_ water, sediment carbon content, and _sediment_ depth [@pon... |
Introduction {#Sec1}
============
Left atrial and ventricular volumes and ejection fraction are important diagnostic and prognostic parameters, widely used in daily practice. Indication for cardiac surgery in patients with valvular abnormalities such as bicuspid aortic valve disease, relies heavily on accurate left ve... | introduction { # sec1 } = = = = = = = = = = = = left atrial and ventricular volumes and ejection fraction are important diagnostic and prognostic parameters, widely used in daily practice. indication for cardiac surgery in patients with valvular abnormalities such as renal aortic valve disease, relies heavily on accura... | Introduction {# S4V1} = = = = = = = = = = = = Left atrial and ventricular volumes and ejection fraction are important diagnostic and prognostic parameters, widely used in daily practice. Indication for cardiac surgery in patients with valvular abnormalities such as bicuspid aortic valve disease, relies heavily on accur... | Introduction {#Sec1} ============ and ventricular volumes and ejection fraction are important diagnostic prognostic parameters, used daily practice. Indication for surgery in patients with valvular abnormalities such as bicuspid aortic valve disease, relies on accurate ventricular (LV) volume and function assessment. F... | INtRODuCtiON {#sEc1}
============
lefT AtRial AND vEntRICuLAr volUMES anD EjECtIoN FRAcTiOn arE importANT diAgNostiC aNd proGnOsTIC PARamETErS, WIdelY uSed IN DailY pRACTice. IndICATIon foR CarDIAc SuRgErY In paTiEnTs With valVULAR abnoRMALItIES SUch As bicUspiD AOrtiC ValVe DISEAse, RELiEs HeavILy oN ACCurATe LefT vE... | Introduction {#Sec1} ============Leftatrialandventricular volumes andejection fraction are important diagnostic and prognostic parameters, widelyused in daily practice. Indication for cardiac surgery in patients with valvular abnormalities suchas bicuspid aortic valvedisease, relies heavily on accurate left ventr... | Introduction {#Sec1} _============_ _Left_ _atrial_ and ventricular volumes and _ejection_ fraction _are_ important _diagnostic_ and prognostic _parameters,_ _widely_ used _in_ daily _practice._ Indication for cardiac surgery in patients with valvular _abnormalities_ such as _bicuspid_ aortic valve disease, _relies_ _h... |
Introduction {#s001}
============
D[espite neonatal polycythemia]{.smallcaps} being more common in infants born to mothers with gestational diabetes mellitus (GDM) than in infants in the general population---to our knowledge---no published study has assessed the hematopoietic stem and progenitor cell (HSPC) population... | introduction { # s001 } = = = = = = = = = = = = d [ espite neonatal polycythemia ] {. smallcaps } being more common in infants born to mothers with gestational diabetes mellitus ( gdm ) than in infants in the general population - - - to our knowledge - - - no published study has assessed the hematopoietic stem and prog... | Introduction {# s001} = = = = = = = = = = = = D [espite neonatal polycythemia] {. smallcaps} being more common in infants born to mothers with gestational diabetes mellitus (GDM) than in infants in the general population - - - to our knowledge - - - no published study has assessed the hematopoietic stem and progenitor ... | Introduction {#s001} ============ D[espite neonatal being more common in infants born to mothers with gestational diabetes (GDM) than in infants in the general population---to our knowledge---no published study has assessed the stem progenitor (HSPC) in the cord blood of neonates born to mothers with GDM. Even in infan... | IntroDUctIOn {#s001}
============
d[esPItE NEonaTAl PoLycytHeMIA]{.SMaLLcaps} BeInG MoRe CommON In infantS BorN To mOThERS with gEstaTIONAl DIAbetES mELLItUs (GDm) ThAN IN INFants iN ThE geneRAl pOpUlatiOn---tO OuR knOWLedgE---NO PUbLIsHeD stUDy hAs AssEssed tHE HEMaTOPoIETiC STem And pROGenItoR CELL (Hspc) PoPUlAtiOn... | Introduction {#s001} ============ D[espite neonatal polycythemia]{.smallcaps} beingmore common in infants born to mothers with gestationaldiabetes mellitus (GDM) than in infants inthe general population---to our knowledge---no published study has assessed the hematopoietic stem and progenitorcell (HSPC) ... | Introduction {#s001} ============ D[espite _neonatal_ _polycythemia]{.smallcaps}_ being more _common_ in _infants_ _born_ to mothers with gestational diabetes mellitus _(GDM)_ than in infants in the general population---to our knowledge---no published study has assessed the hematopoietic _stem_ and progenitor cell (HSP... |
INTRODUCTION {#s1}
============
BREAST CANCER {#s2}
=============
At present, one in eight women in the United States will develop breast cancer \[[@R1]\]. Recent advances in breast cancer detection and treatment have decreased the mortality rate of breast cancer \[[@R1]\] but the success of treatment relies largely ... | introduction { # s1 } = = = = = = = = = = = = breast cancer { # r } = = = = = = = = = = = = = at present, one in eight women in the developing nations will develop breast cancer \ [ [ @ r1 ] \ ]. recent advances in breast cancer detection and detection have decreased the mortality rate of breast cancer \ [ [ @ r1 ] \ ]... | INTRODUCTION {# s1} = = = = = = = = = = = = BREAST CANCER {# s2} = = = = = = = = = = = = = At present, one in eight women in the United States will develop breast cancer \ [[ @ R1] \ ]. Recent advances in breast cancer detection and treatment have decreased the mortality rate of breast cancer \ [[ @ R1] \] but the succ... | INTRODUCTION {#s1} ============ BREAST CANCER {#s2} ============= At present, one eight women in the United States will develop breast cancer \[[@R1]\]. Recent breast cancer detection and treatment have decreased the mortality rate breast cancer \[[@R1]\] but success of treatment largely on detection of the at early \[... | intRODUCtIOn {#S1}
============
bREAST cAnCER {#s2}
=============
At pReseNt, onE in eighT WoMEN In tHe unIteD StaTES WiLL DEVeLoP BReasT CanCeR \[[@r1]\]. reCEnt ADvanCes IN BREaSt caNCer deteCtioN anD trEATmeNt have decReasED THE MORtAlitY RATe of breasT CanCer \[[@R1]\] bUt tHE sUCcesS OF tReaTMent RELieS LaRgeLy ... | INTRODUCTION {#s1} ============ BREAST CANCER {#s2} ============= At present,one in eight women in the UnitedStates will develop breast cancer \[[@R1]\]. Recent advancesin breast cancer detection and treatment havedecreased themortality rate of breast cancer \[[@R1]\] but the success of treatmentrelies ... | INTRODUCTION {#s1} ============ BREAST CANCER _{#s2}_ ============= At present, _one_ _in_ eight women in the United States will develop breast cancer \[[@R1]\]. Recent advances in _breast_ cancer detection and treatment _have_ decreased the mortality rate of breast cancer \[[@R1]\] but the _success_ of treatment _reli... |
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