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Regions of the genome that have been the target of positive selection specifically along the human lineage are of special importance in human biology. We used high throughput sequencing combined with methods to enrich human genomic samples for particular targets to obtain the sequence of 22 chromosomal samples at high ... | The search for functional regions in the human genome, beyond the protein-coding portion, often relies on signals of conservation across species. The Human Accelerated Regions (HARs) are strongly conserved elements, ranging in size from 100-400 bp, that show an unexpected number of human-specific changes. This pattern ... | lay_plos |
Tropical pathogens often cause febrile illnesses in humans and are responsible for considerable morbidity and mortality. The similarities in clinical symptoms provoked by these pathogens make diagnosis difficult. Thus, early, rapid and accurate diagnosis will be crucial in patient management and in the control of these... | Tropical diseases consist of a group of debilitating and fatal infections that occur primarily in rural and urban settings of tropical and subtropical countries. While the primary indices of an infection are mostly the presentation of clinical signs and symptoms, outcomes due to an infection with tropical pathogens are... | lay_plos |
The unnoticed lives that the pair had hitherto led began, from the day of the suspended wedding onwards, to be observed and discussed by other persons than Arabella. The society of Spring Street and the neighbourhood generally did not understand, and probably could not have been made to understand, Sue and Jude's priva... | Jude and Sue's postponement of their marriage is noticed by the neighbors at Aldbrickham, who begin to gossip about them. Little Father Time is teased at school. Sue and Jude decide to go off to London for a few days and then return, pretending they have been married there. But the scandal continues, and the neighbors ... | booksum |
Background The federal government has historically established minimum eligibility requirements for Medicaid and CHIP and provided states with considerable flexibility in expanding eligibility to individuals in households with higher incomes. PPACA made numerous changes to existing federal Medicaid and CHIP eligibility... | PPACA sought to increase access to affordable health insurance, and major provisions, such as a tax credit to offset the cost of private insurance premiums, will become effective in 2014. GAO estimated the extent to which (1) uninsured children would be eligible for Medicaid, CHIP, or the premium tax credit under PPACA... | gov_report |
Rupert Murdoch supposedly wished his old employee Piers Morgan well, but not too much success in his new gig on CNN. The News Corp. chairman, ever mindful of Fox News' profits, needn't have worried. "Piers Morgan Tonight" is the second holdover from CNN's former management, and to say the show's debut was more polished... | The obnoxious Piers Morgan familiar to reality show fans was nowhere to be seen as Piers Morgan Tonight made its debut in Larry King's old time slot on CNN, say critics. Morgan was fawning and deferential during his highly publicized interview with Oprah Winfrey. Some early reaction: "Morgan's nerves showed in his voic... | multi_news |
Summarize the decision of the discussion on the name chosen of the product.
Project Manager: Can I close this?
User Interface: Uh we don't have any changes, do we?
Project Manager: Oh, okay.
User Interface: So no. {vocalsound}
Project Manager: {vocalsound} There we go. Okay, here we are again. Detailed design {disfmark... | They agreed to cross out'banana remote','the deluxe'from the options. They all agreed on the'triple R'without arguments, because the group thought it looked cool when it was printed out. In addition, it was short and catchy. | qmsum |
SECTION 1. SHORT TITLE. This Act may be cited as the ``Victims of Domestic Abuse Insurance Protection Act of 1996''. SEC. 2. DEFINITIONS. As used in this Act: (1) The term ``domestic abuse'' means the occurrence of one or more of the following acts between former or current household or family members (including in-law... | Victims of Domestic Abuse Insurance Protection Act of 1996 - Prohibits insurers and group health plans from engaging, directly or indirectly, in specified discriminatory acts or practices on the basis that the applicant or insured, or any person employed by the applicant or insured or with whom the applicant or insured... | billsum |
Background This background discusses (1) the distribution network for natural gas pipelines, (2) the key federal environmental laws that may be involved in the permitting process for these pipelines, and (3) the key stakeholders that may be involved in the permitting process. Distribution Network for Natural Gas Pipeli... | Recent growth in domestic natural gas production, particularly due to increased production from shale, is resulting in an increase in the pipelines needed to transport that gas. Constructing natural gas pipelines requires clearing and maintaining rights-of-way, which may disturb habitat and historical and cultural reso... | gov_report |
Everybody knows that Silicon Valley has become an economic powerhouse over the past quarter-century, but Houston’s boom is less appreciated. Joel Kotkin of Chapman University points out that over the past decade, Houston has outperformed every major metropolitan area in income growth, population growth and migration. S... | The consensus heading into crunch time of the midterm elections is that they're... boring. (See here and here, or check out a recent Pew poll showing the anemic level of interest among Americans-only about 15% are closely following things.) Midterms always lack the punch of a presidential election, of course, but this ... | multi_news |
Background Contracts are generally considered to be physically complete once all option provisions have expired, the contractor has completed performance, and the government has accepted the final delivery of supplies or services. Physically completed contracts should then be closed within time frames set by the FAR—6 ... | Closing contracts is a key step in the contracting process. GAO and others have previously reported that large numbers of contracts were not closed within time frames set by federal regulations, which can expose the government to financial risk. DCAA's backlog of audits of contractors' incurred cost proposals contribut... | gov_report |
This is a set of web collections curated by Mark Graham using the Archive-IT service of the Internet Archive. They include web captures of the ISKME.org website as well as captures from sites hosted by IGC.org.These web captures are available to the general public.For more information about this collection please feel ... | As the world's richest and most powerful people leave the World Economic Forum in Davos, Switzerland, there was growing discussion about the impact the world's wealthiest could have, single-handedly, on the poverty rates of entire nations. One analyst at the Brookings Institution crunched some numbers and found that, i... | multi_news |
SECTION 1. SHORT TITLE. This Act may be cited as the ``Tribal General Welfare Exclusion Act of 2013''. SEC. 2. INDIAN GENERAL WELFARE BENEFITS. (a) In General.--Part III of subchapter B of chapter 1 of the Internal Revenue Code of 1986 is amended by inserting before section 140 the following new section: ``SEC. 139E. I... | Tribal General Welfare Exclusion Act of 2013 - Amends the Internal Revenue Code to exclude from gross income, for income tax purposes, the value of an Indian general welfare benefit. Defines "Indian general welfare benefit" as any payment made or services provided to or on behalf of a member of an Indian trib... | billsum |
Background Industrial security integrates information, personnel, and physical security to protect classified information entrusted to contractors. The goal is to ensure that contractors’ security programs detect and deter espionage and counter the threat posed by adversaries seeking classified information. According t... | Department of Defense (DOD) contractors perform numerous services that require access to classified information. With access comes the possibility of compromise, particularly as foreign entities increasingly seek U.S. military technologies. To ensure the protection of classified information, the National Industrial Sec... | gov_report |
Endophytic insects provide the textbook examples of herbivores that manipulate their host plant’s physiology, putatively altering source/sink relationships by transferring cytokinins (CK) to create ‘green islands’ that increase the nutritional value of infested tissues. However, unambiguous demonstrations of CK transfe... | Many insects use plants for food and for shelter. To protect themselves, plants often develop defense mechanisms that deter or debilitate their attackers, such as producing toxins or storing nutrients away from the attacked tissues. But some insects manage to counter the plants' defense responses. Such species are ofte... | lay_elife |
Gay-rights activist and award-winning author Larry Kramer is 79 and in failing health, but that won’t defuse the impact of his latest bombshell project: the first 800-page instalment of a two-part history of America that tells of the secret gay life of figures from Alexander Hamilton, George Washington and Abraham Linc... | George Washington and Abraham Lincoln were gay. So were Alexander Hamilton, Herman Melville, and Richard Nixon-at least according to a new book that the author considers true but his publisher is selling as fiction to avoid legal problems, the Guardian reports. Needless to say, Larry Kramer's 800-page The American Peop... | multi_news |
Mr. Partilla, then a 42-year-old triathlete and a president of media sales at Time Warner, recognized a kindred dynamo. “She’s such a force,” he said. “She rocks back and forth on her feet as if she can’t contain her energy as she’s talking to you.” Advertisement Continue reading the main story The connection was immed... | The New York Times' normally genteel "Vows" column hit a nerve on Sunday, with its tale of John Partilla and Carol Riddell-who each left spouses to get hitched. It's "part Brady Bunch, part The Scarlet Letter," the paper cooed. Bloggers and commenters tore the paper a new one. "These things happen," says New York magaz... | multi_news |
Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6,2-phenoxy-1,4-naphthoquinone) showed an ED50 of 80 nM against Trypanosoma brucei rhodesiense, and a selectivity index of 74 with respect to mammalian ... | The multitarget approach can represent a promising strategy for the discovery of innovative drug candidates against neglected tropical diseases. However, multitarget drug discovery can be very demanding, because of the highly time-consuming step related to the fine balancing of the biological activities against selecte... | lay_plos |
2 children among more than 100 people held hostage in Houston stash house HOUSTON—More than 100 suspected illegal immigrants were found living in deplorable conditions in a south Houston stash house Wednesday, police said. The men, women and children were held against their will by smugglers or coyotes. One officer des... | Houston police last Wednesday uncovered a grim building covered in human waste and packed with 115 people held hostage inside. Court papers filed in the case against five alleged human smugglers provide more insight into how the "stash house" came to be, and how police uncovered it. The Houston Chronicle reports that t... | multi_news |
Monocytes are circulating short-lived macrophage precursors that are recruited on demand from the blood to sites of inflammation and challenge. In steady state, classical monocytes give rise to vasculature-resident cells that patrol the luminal side of the endothelium. In addition, classical monocytes feed macrophage c... | Macrophage cells play a crucial role in keeping the body free of disease-causing microbes and debris. They surveille the tissues, detect and clear infections, and tidy up dead cells. Most internal organs contain a population of macrophages that move into the organ during development and then persist throughout an organ... | lay_elife |
FIELD OF THE INVENTION [0001] The invention relates to a device for irradiating absorbing liquids, for example wastewater that is to be disinfected, with UV radiation. PRIOR ART [0002] Devices for treating sewage treatment plant effluent for the purpose of reducing the germ count have long been known. The underlying re... | The invention relates to a device for irradiating an absorbing liquid, for example waste water to be disinfected, in a throughflow. Said device comprises at least two radiator units having one cylindrical UV radiation source and three concentric sheaths. A cooling medium for carrying off heat from the UV radiation sour... | big_patent |
Nucleocytoplasmic trafficking is emerging as an important aspect of plant immunity. The three related pathways affecting plant immunity include Nuclear Localization Signal (NLS) –mediated nuclear protein import, Nuclear Export Signal (NES) –dependent nuclear protein export, and mRNA export relying on MOS3, a nucleopori... | In eukaryotic cells, mRNAs are synthesized in the nucleus where they are processed (capped, spliced, poly-adenylated, and carried toward the nuclear pore) prior to being exported to the cytoplasm for translation. Insights into mRNA export mechanisms have been gained mostly from studies on yeast and humans, while little... | lay_plos |
CROSS-REFERENCES TO RELATED APPLICATIONS This application claims the benefit of the provisional patent application Ser. No. 60/763,998 filed 2006 Feb. 1 by the present inventor. FEDERALLY SPONSORED RESEARCH None SEQUENCE LISTING None BACKGROUND This invention relates to carrying bags, specifically to carrying bags that... | This invention presents strap apparatus that is attached to a carrying bag such as a briefcase, computer bag, or golf club bag. In the first embodiment, the strap apparatus is constructed from a single strap that is configured as a closed loop. The closed loop is constrained to the sides of the bag near the top by two ... | big_patent |
Transition row metal ions are both essential and toxic to microorganisms. Zinc in excess has significant toxicity to bacteria, and host release of Zn (II) at mucosal surfaces is an important innate defence mechanism. However, the molecular mechanisms by which Zn (II) affords protection have not been defined. We show th... | Dietary zinc deficiency is a global health problem affecting almost two billion people. Infectious diseases associated with zinc deficiency include respiratory infections caused by bacteria, and notably, Streptococcus pneumoniae, which is responsible for more than 1 million deaths annually. The association between zinc... | lay_plos |
Bracoviruses are symbiotic viruses associated with tens of thousands of species of parasitic wasps that develop within the body of lepidopteran hosts and that collectively parasitize caterpillars of virtually every lepidopteran species. Viral particles are produced in the wasp ovaries and injected into host larvae with... | Eukaryotes are generally thought to evolve mainly through the modification of existing genetic information. However, evidence of horizontal gene transfer (HGT) in eukaryotes-the accidental acquisition of a novel gene from another species, allowing acquisition of novel traits-is now recognized as an important factor in ... | lay_plos |
People who reported eating fast food in the last 24 hours had elevated levels of some industrial chemicals in their bodies, according to a new analysis of data from federal nutrition surveys. The study is the first broad look at how fast food may expose the public to certain chemicals, called phthalates, that are used ... | People who eat fast food may have higher levels of potentially infertility-causing industrial chemicals in their body, according to a new study. Bloomberg reports researchers were looking specifically at DEHP and DiNP, two types of phthalates found in everything from cosmetics to window blinds. They studied nutrition d... | multi_news |
CROSS-REFERENCE TO RELATED APPLICATION [0001] Applicant claims priority from Provisional patent applications 60/311,440, 60/311,441, and 60/311,610, all filed Aug. 10, 2001. BACKGROUND OF THE INVENTION [0002] Earplugs are commonly produced by punching a plug out of a plate of material or molding individual earplugs in ... | An earplug arrangement enables low cost manufacture and storage of earplugs and convenient dispensing of individual earplugs. The earplugs are formed from an extrusion of a maximum diameter of about 12 mm and with narrow locations spaced apart by about 1 to 5 cm to separate the extrusion into a chain of at least ten ea... | big_patent |
That afternoon with Rima in the forest under the mora tree had proved so delightful that I was eager for more rambles and talks with her, but the variable little witch had a great surprise in store for me. All her wild natural gaiety had unaccountably gone out of her: when I walked in the shade she was there, but no lo... | Abel, certain that the old man has been less than honest with him, determines to learn about Rima's history from Nuflo because he knows now that the girl will not willingly reveal the whole truth. Rima, moreover, has become very aloof after their meeting at the mora tree. Nuflo disappears with his dogs for long hours d... | booksum |
Group 2 Innate lymphoid cells (ILC2s) are innate cells that produce the TH2 cytokines IL-5 and IL-13. The importance of these cells has recently been demonstrated in experimental models of parasitic diseases but there is a paucity of data on ILC2s in the context of human parasitic infections and in particular of the bl... | Understanding how immune responses are generated is critical for vaccine development. There are comparatively few studies on the interface between the innate and adaptive immune system in generating protective immune responses. Infections with helminth parasites, a cause of neglected tropical diseases, have a huge coll... | lay_plos |
Mr Verloc, going out in the morning, left his shop nominally in charge of his brother-in-law. It could be done, because there was very little business at any time, and practically none at all before the evening. Mr Verloc cared but little about his ostensible business. And, moreover, his wife was in charge of his broth... | Meet Mr. Verloc, who's leaving his brother-in-law in charge of his London shop as he steps out for a little walk. The brother-in-law doesn't sound all that capable of running the place, but truth is that Verloc doesn't really care all that much about his "ostensible" business. The shop is attached to his house, which i... | booksum |
CROSS-REFERENCES TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser. No. 12/659,963 filed Mar. 26, 2010, which is a continuation of U.S. patent application Ser. No. 10/533,940 (issued as U.S. Pat. No. 8,006,691) filed May 4, 2005, which is a national stage application of PCT/AU04/00810, ... | A humidifier has a base unit with an engagement face that is configured to interface with a flow generator. The humidifier also has a tank configured to be removably received by the base unit and hold a volume of liquid. The tank has a side wall with an air inlet. The humidifier further has an air flow passage configur... | big_patent |
SECTION 1. SHORT TITLE. This Act may be cited as the ``Nuclear Regulatory Commission Reorganization Plan Codification and Complements Act''. TITLE I--REPLACEMENT OF REORGANIZATION PLAN SEC. 101. GENERAL FUNCTIONS. (a) Functions.--Those functions of the Nuclear Regulatory Commission (in this title referred to as the ``C... | Nuclear Regulatory Commission Reorganization Plan Codification and Complements Act - Codifies and expands the Reorganization Plan No. 1 of 1980 governing the administration of the Nuclear Regulatory Commission (NRC). Identifies approval of the distribution of appropriated funds according to programs and purposes propos... | billsum |
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states. Previous studies have functionally implicated the NMDA receptor-NO pathway and the downstream seco... | Pain is an important physiological function that protects our body from harm. Pain-sensing neurons, called nociceptors, transduce harmful stimuli into electrical signals and transmit this information to the brain via the spinal cord. When nociceptors are persistently activated, such as after injury, the connections the... | lay_plos |
(CNN) Every detail of this indiscriminate mass murder seemed meticulously planned. The selection of a hotel room overlooking a music festival, days before the attack. The cache of 23 weapons inside the gunman's Las Vegas suite. And thousands of rounds of ammunition -- plus an ingredient used in explosives -- inside the... | As investigators try to piece together a motive behind Sunday night's massacre in Las Vegas, stories of heroism are emerging. Rusty Dees says that after gunman Stephen Paddock opened fire on the Route 91 Harvest country music festival, concertgoers tried to take care of each other amid the panic and bloodshed. "It take... | multi_news |
Vascular network density determines the amount of oxygen and nutrients delivered to host tissues, but how the vast diversity of densities is generated is unknown. Reiterations of endothelial-tip-cell selection, sprout extension and anastomosis are the basis for vascular network generation, a process governed by the VEG... | Many animals have a network of blood vessels that supplies oxygen and nutrients to every part of the body. Each organ contains a unique pattern of blood vessels; some have lots of densely packed vessels, while others have fewer vessels that are more widely spaced. New blood vessels typically form by sprouting from the ... | lay_elife |
Summarize the discussion about specific details connected with market interests.
Project Manager: So we come to the third meetings. I have {gap} good.
Industrial Designer: {vocalsound}
Project Manager: Um so in the last meeting we have discussed the functional design and now we will talk about the conceptual design. So... | The team discussed a marketing survey about remote controls. They agreed to design remote controls with more fancy outlook and less buttons. The remote control should be easier to find and less complicated so users take less time to learn the functionality of it and the team discussed how to implement this function. Th... | qmsum |
Identifying functionally critical regions of the malaria antigen AMA1 (apical membrane antigen 1) is necessary to understand the significance of the polymorphisms within this antigen for vaccine development. The crystal structure of AMA1 in complex with the Fab fragment of inhibitory monoclonal antibody 1F9 reveals tha... | Malaria caused by Plasmodium falciparum causes more than 1 million deaths annually, and the development of a vaccine against this parasite is a major public health priority. Development of a vaccine is considered feasible because infection with malaria parasites induces protective immune responses, which include antibo... | lay_plos |
Calcium/calmodulin-dependent protein kinase II (CAMK2) plays fundamental roles in synaptic plasticity that underlies learning and memory. Here, we describe a new recessive neurodevelopmental syndrome with global developmental delay, seizures and intellectual disability. Using linkage analysis and exome sequencing, we f... | Each year, some children are born with developmental disorders and intellectual disabilities. These conditions are often caused by mutations in specific genes. Sometimes both copies of a gene - one inherited from each parent - need to be mutated for the symptoms to develop. These mutations are known as recessive mutati... | lay_elife |
(Open: Hotel - Laundry Area. There are gigantic washing machines and dryers all around. Workers are doing laundry. A man is walking around the floor with a woman.)
HOTEL MANAGER: They put me in charge of all of this. I'm like one of those big shots on Wall Street only I deal with laundry, instead of money.
WOMAN: Wow.
... | When the body of a rich adventure-seeker is found in a hotel laundry machine, Booth and Brennan are led to the last place he was seen: a Rock 'n Roll Fantasy Camp. While Brennan and Booth lead the investigation outside the lab, Hodgins, Angela and intern Arastoo use a fragment of prehistoric wooly mammoth tusk - found ... | summ_screen_fd |
The infection cycle of viruses creates many opportunities for the exchange of genetic material with the host. Many viruses integrate their sequences into the genome of their host for replication. These processes may lead to the virus acquisition of host sequences. Such sequences are prone to accumulation of mutations a... | Many studies focused on the exchange of genetic material between viruses and cellular hosts. The diversity of viruses argues that, along the evolutionary history, viruses have shaped the host genomes. While most viruses have many opportunities to exchange genetic material with their hosts, tracing such events is challe... | lay_plos |
The accumulation of heteroplasmic mitochondrial DNA (mtDNA) deletions and single nucleotide variants (SNVs) is a well-accepted facet of the biology of aging, yet comprehensive mutation spectra have not been described. To address this, we have used next generation sequencing of mtDNA-enriched libraries (Mito-Seq) to inv... | Mitochondria are unique among animal organelles in that they contain their own multi-copy genome (mtDNA). For the past 20 years it has been known that tissues like brain and muscle accumulate somatic mtDNA mutations with age. Because individual mtDNA mutations are present at very low levels, few details are known about... | lay_plos |
Complex tissues, such as the brain, are composed of multiple different cell types, each of which have distinct and important roles, for example in neural function. Moreover, it has recently been appreciated that the cells that make up these sub-cell types themselves harbour significant cell-to-cell heterogeneity, in pa... | Tissues within complex multi-cellular organisms have historically been defined in terms of their anatomy and function. More recently, experimental approaches have shown that different tissues express distinct batteries of genes, thus providing an additional metric for characterising them. These experiments have been pe... | lay_plos |
A fundamental observation of comparative genomics is that the distribution of evolution rates across the complete sets of orthologous genes in pairs of related genomes remains virtually unchanged throughout the evolution of life, from bacteria to mammals. The most straightforward explanation for the conservation of thi... | A central concept of evolution is Molecular Clock according to which each gene evolves at a characteristic, near constant rate. Numerous studies support the Molecular Clock hypothesis in principle but also show that the clock is indeed very approximate. Genome-wide comparative analysis of phylogenetic trees described h... | lay_plos |
ACT V. SCENE 2. The Grecian camp. Before CALCHAS' tent Enter DIOMEDES DIOMEDES. What, are you up here, ho? Speak. CALCHAS. [Within] Who calls? DIOMEDES. Diomed. Calchas, I think. Where's your daughter? CALCHAS. [Within] She comes to you. Enter TROILUS and ULYSSES, at a distance; after them THERSITES ULYSSES. Stand wher... | At Calchas's tent, Diomedes calls to Cressida. Her father fetches her, while Troilus and Ulysses watch from one hiding place and Thersites from another. With Thersites's profanity and Troilus's shock providing a counterpoint, Diomedes woos Cressida, who behaves reluctantly but coyly toward his advances, fending him off... | booksum |
Mass drug administration (MDA) programs have dramatically reduced lymphatic filariasis (LF) incidence in many areas around the globe, including American Samoa. As infection rates decline and MDA programs end, efficient and sensitive methods for detecting infections are needed to monitor for recrudescence. Molecular met... | Lymphatic filariasis (LF), a mosquito-borne parasitic disease, has been targeted for elimination in many countries since the introduction of mass drug administration (MDA) programs using two-drug combinations along with improved diagnostic methods. Sensitive molecular methods detecting parasite DNA in pools of mosquito... | lay_plos |
Apple has been valued at more than $1tn – almost three times as much as Google, the US’s second most valuable company. Analysts at Cantor Fitzgerald on Monday said they thought Apple’s shares – which are currently trading at about $127, valuing the company at $733bn – could soon be worth $180 each, which would value th... | Before Tim Cook kicks the bucket-and after he sets aside enough money for his 10-year-old nephew's education-he plans to leave all of his wealth to charity. In an interview with Fortune, the CEO of Apple, which could soon become the world's first company worth $1 trillion, says he has already begun donating quietly. Wh... | multi_news |
[Outside Babylon. Brian pounces on Justin.]
Brian: I'm gonna f*ck you. I'm gonna f*ck you all night long. [ They make out.]
Justin: Aren't you getting enough?
Brian: Never, enough.
Justin: Why we can't save it until the weekend?
Brian: Why should we save it? So, we're get the car.
Justin: I was thinking that we could g... | Brian has to cancel plans with Justin to impress his new boss at work. Emmett receives a VERY generous gift from the late George. Melanie and Lindsay fight off the dreaded Lesbian Bed Death. | summ_screen_fd |
Gram-positive bacteria, including Staphylococcus aureus are endemic in the U. S., which cause life-threatening necrotizing pneumonia. Neutrophils are known to be critical for clearance of S. aureus infection from the lungs and extrapulmonary organs. Therefore, we investigated whether the NLRP6 inflammasome regulates ne... | Gram-positive bacteria, including Staphylococcus aureus remain a major cause of acute pneumonia worldwide. Due to emergence of multidrug-resistant strains, alternative strategies for treatment of S. aureus pneumonia are needed. To this end, it may be possible to harness host defenses to eradicate the infection instead ... | lay_plos |
Telomerase is expressed in early human development and then becomes silenced in most normal tissues. Because ~90% of primary human tumors express telomerase and generally maintain very short telomeres, telomerase is carefully regulated, particularly in large, long-lived mammals. In the current report, we provide substa... | Telomerase is very tightly regulated in large, long-lived species such as humans. Telomerase is expressed during early human fetal development, turned off in most adult tissues, and then becomes reactivated in most human cancers. However, the exact mechanism (s) regulating these switches in expression are not fully kno... | lay_plos |
Ted from 2030: Kids, one morning in 2010, I opened the newspaper only to discover an op-ed written by Zoey Pierson. You remember Zoey.
[FLASHBACK]
Zoey: Key Ted Mosby's car.
[END OF FLASHBACK]
Ted from 2030: In those four column inches, she railed against me and my company, GNB, for wanting to tear down a beautiful old... | When the gang goes to a black-tie event at the Natural History Museum, Ted gets introduced to Zoey's husband, The Captain. Barney and Robin dare each other to break the laws of the museum by touching all of the exhibits. | summ_screen_fd |
Orientia tsutsugamushi (Ots) frequently causes severe scrub typhus infections in the Asia-Pacific region. Korean investigators have demonstrated that Ots encodes five different autotransporter domain (ATD) proteins (ScaA-ScaE). ScaA functions as an adhesin and confers protective immunity in a lethal mouse model of Ots ... | Orientia tsutsugamushi (Ots) frequently causes severe scrub typhus infections in the Asia-Pacific region. Korean investigators had previously demonstrated that Ots encodes five different cell surface (Sca) proteins which have functional regions that mediate their transport to the cell surface. One of the proteins (ScaA... | lay_plos |
Police now outnumber protesters at Frank H. Ogawa Plaza. People have been in the plaza all day after police cleared more than 100 tents from the Occupy Oakland encampment. The 5 a.m. police action was peaceful, although 33 people were arrested for failing to disperse. Most have been released. Marchers gathered Monday a... | Police in riot gear moved to clear out the Occupy Oakland camp early today, arresting dozens as protesters watched. Hundreds of police moved in at about 5am, according to the San Francisco Chronicle. Protesters had broken into two groups, with some defending the tent city and hundreds of others standing, marching, and ... | multi_news |
What’s new this flu season? A few things are new this season: Flu vaccines have been updated to better match circulating viruses [the B/Victoria component was changed and the influenza A(H3N2) component was updated]. For the 2018-2019 season, the nasal spray flu vaccine (live attenuated influenza vaccine or “LAIV”) is ... | An unvaccinated child in Florida has become the first death of flu season, officials say. The child, whose age and hometown has not been disclosed, died between Sept. 30 and Oct. 6 of influenza B, ABC reports. Officials say the child was otherwise healthy, with no underlying conditions. According to the Centers for Dis... | multi_news |
Highly pathogenic H5N1 influenza A viruses have spread across Asia, Europe, and Africa. More than 500 cases of H5N1 virus infection in humans, with a high lethality rate, have been reported. To understand the molecular basis for the high virulence of H5N1 viruses in mammals, we tested the virulence in ferrets of severa... | Highly pathogenic H5N1 influenza A viruses have caused more than 500 human infections with approximately 60% lethality in 15 countries and continue to pose a pandemic threat. The recent worldwide spread of pandemic H1N1 influenza A viruses raises the concern of reassortment between the H5N1 viruses and other influenza ... | lay_plos |
The visual world is complex and continuously changing. Yet, our brain transforms patterns of light falling on our retina into a coherent percept within a few hundred milliseconds. Possibly, low-level neural responses already carry substantial information to facilitate rapid characterization of the visual input. Here, w... | Humans excel in rapid and accurate processing of visual scenes. However, it is unclear which computations allow the visual system to convert light hitting the retina into a coherent representation of visual input in a rapid and efficient way. Here we used simple, computer-generated image categories with similar low-lev... | lay_plos |
Dark spruce forest frowned on either side the frozen waterway. The trees had been stripped by a recent wind of their white covering of frost, and they seemed to lean towards each other, black and ominous, in the fading light. A vast silence reigned over the land. The land itself was a desolation, lifeless, without move... | Two men, Bill and Henry, apparently drew the short straw, and have to haul a dead body to Fort McGurry. Along the way, they are chased by a pack of hungry wolves. One clever wolf, a female with a red sheen to her coat, is sneaking into the camp and stealing fish. She cunningly makes the two men lose count of how many d... | booksum |
The endosymbiotic bacteria Wolbachia pipientis (wMel strain) has been successfully established in several populations of Aedes aegypti, the primary dengue vector. The virulent Wolbachia strain wMelPop is known to cause several pathological impacts (increased egg mortality, life shortening, etc.) reducing overall fitnes... | Dengue is a leading cause of morbidity in the tropics. As a commercial vaccine is not available, control or modification of the mosquito vectors is employed to prevent transmission. Strains of the endosymbiotic bacteria Wolbachia affect the survival and ability of the dengue vector Aedes aegypti to transmit dengue. The... | lay_plos |
These crawls are part of an effort to archive pages as they are created and archive the pages that they refer to. That way, as the pages that are referenced are changed or taken from the web, a link to the version that was live when the page was written will be preserved.Then the Internet Archive hopes that references ... | Irritated by the proliferation of stray cats and dogs? Just move to Utah, where soon you'll be able to take care of the problem... by shooting them. The Stir points to a new law being proposed by Rep. Curt Oda, a Republican who wants to legalize the killing of all feral animals. Of course, in order for the killing to b... | multi_news |
The pathogenesis of bacteraemia after challenge with one million pneumococci of three isogenic variants was investigated. Sequential analyses of blood samples indicated that most episodes of bacteraemia were monoclonal events providing compelling evidence for a single bacterial cell bottleneck at the origin of invasive... | Decades of research on bacterial sepsis have been devoted to analysing the steps that lead from a local event, either carriage or a localised infection, to systemic disease. Our work analyses in depth the events determining systemic infection by one of the main human pathogens, Streptococcus pneumoniae. Consistent with... | lay_plos |
Between March 2014 and July 2015 at least 10,500 Ebola cases including more than 4,800 deaths occurred in Liberia, the majority in Monrovia. However, official numbers may have underestimated the size of the outbreak. Closure of health facilities and mistrust in existing structures may have additionally impacted on all-... | During the Ebola outbreak in 2014/2015 more than 4,800 people died of Ebola in Liberia. Health care providers in the field have assumed that closure of health facilities and mistrust in existing structures resulted not only substantial additional deaths from Ebola but also impacted on death rate of other diseases and o... | lay_plos |
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases. While gamma amino-butyric acid Type A (GABAA) receptors are the primary molecular targets of neurosteroid action, the structural details o... | Neurosteroids are cholesterol metabolites produced by neurons and glial cells that participate in central nervous system (CNS) development, regulate neuronal excitability, and modulate complex behaviors such as mood. Exogenously administered neurosteroid analogues are effective sedative hypnotics and are being develope... | lay_plos |
Produced by: Wendy Knoller Final check by Kim
[Scene: Central Perk. Everybody's sitting on the couch and Monica is eating a chunk of cake.]
Monica: (really excited) Mmh... this cake is amazing!
Rachel: My God, get a room!
Monica: I would get a room with this cake. I think I could show this cake a good time!
Phoebe: If ... | Rachel and Phoebe see Chandler getting into a car with another woman. He dodges their questions by pretending to be at work but they follow him to the suburbs and find them entering a house. They believe he is cheating on Monica and tell Ross and Joey. The four of them tell Monica but Monica doesn't react the way they ... | summ_screen_fd |
[EXT. LAS VEGAS (STOCK) -- NIGHT]
[SCENE_BREAK]
[INT. DEVON HOTEL -- LOBBY -- NIGHT]
(A MAN and A WOMAN walk through the lobby, their arms around each other.)
Man: You're going to like my room. You can see the entire strip from my balcony ... and the bed.
(He turns her around, her back against the wall. Her hands come ... | The CSI team is called in when a famous real estate entrepreneur is found dead in a hotel elevator. When the body of Bob Fairmont, the real estate developer, is found, the team discovers that the crime scene has been tampered with and that the victim has been re-dressed. After tracing the cause of death to a lethal poi... | summ_screen_fd |
How do adapting populations navigate the tensions between the costs of gene expression and the benefits of gene products to optimize the levels of many genes at once? Here we combined independently-arising beneficial mutations that altered enzyme levels in the central metabolism of Methylobacterium extorquens to uncove... | The pace and outcome of a series of adaptive steps in an evolving lineage depends upon how well different beneficial mutations stack on top of each other. We found that independent beneficial mutations that affected gene expression for a metabolic pathway did not work well together, and were often jointly deleterious. ... | lay_plos |
Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized by skin rash (poikiloderma), skeletal dysplasia, small stature, juvenile cataracts, sparse or absent hair, and predisposition to specific malignancies such as osteosarcoma and hematological neoplasms. RTS is caused by germ-line mutatio... | DNA helicases unwind double-stranded nucleic acids using energy from ATP to access genetic information during cell replication. In humans, several families of helicases have been described and one of particular importance is the RecQ family, where mutations in three of five members cause human disease. RECQL4 is a memb... | lay_plos |
Madame Merle, who had come to Florence on Mrs. Touchett's arrival at the invitation of this lady--Mrs. Touchett offering her for a month the hospitality of Palazzo Crescentini--the judicious Madame Merle spoke to Isabel afresh about Gilbert Osmond and expressed the hope she might know him; making, however, no such poin... | Madame Merle returns to Palazzo Crescentini, Mrs. Touchett's home in Florence. Madame Merle recommends Osmond to Isabel once more, telling her of his impressive traits. She ominously tells Isabel that she should interact with more men, so that she gets "used" to them - that is to say, so she learns which ones to despis... | booksum |
CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation of U.S. application Ser. No. 10/141,494, filed on May 7, 2002, which is a continuation of U.S. application Ser. No. 09/608,940, filed on Jun. 30, 2000, now U.S. Pat. No. 6,383,156, which claims the benefit of U.S. provisional application ... | An orthopaedic brace includes a strut length adjustment assembly to change the operable length of the strut for sizing the brace on a patient without the need for special tools or cutting of the strut. The adjustment assembly includes a biased adjustment mechanism that coacts with a plurality of notches in the strut to... | big_patent |
THE MONSTER OF PELADON
BY: BRIAN HAYLES
PART FIVE
5:30pm - 5:55pm
[SCENE_BREAK]
1: INT. COMMUNICATIONS ROOM
AZAXYR: The sonic lance has a self-destruct circuit...which I have already pre-set by remote control. If the rebel should try to fire it, it will destroy itself. It will, of course, kill all those in the area.
(S... | Sarah and Alpha Centauri decide to try and alert the Federation to what the Ice Warriors are up to but first they have to escape from the throne room. | summ_screen_fd |
Breaking News Emails Get breaking news alerts and special reports. The news and stories that matter, delivered weekday mornings. SUBSCRIBE For decades, Hollywood producer Bob Weinstein appeared to live in the outsize shadow of his older brother, Harvey. Harvey Weinstein was the public face of the studios they co-founde... | Bob Weinstein's prior knowledge of the sexual harassment and assault allegations now piling up against his brother, Harvey Weinstein, isn't clear. What is clear is that the brothers were in the midst of a rift that the scandal would only expose. According to the Los Angeles Times, the brothers with a reputation for noi... | multi_news |
Spinal muscular atrophy is a severe motor neuron disease caused by inactivating mutations in the SMN1 gene leading to reduced levels of full-length functional SMN protein. SMN is a critical mediator of spliceosomal protein assembly, and complete loss or drastic reduction in protein leads to loss of cell viability. Howe... | The identification of mutations in the Survival Motor Neuron (SMN) gene as the cause of the severe motor neuron disorder spinal muscular atrophy is one of a number of discoveries implicating selective motor neuron vulnerability to defects in processing of RNA and its associated ribonucleoprotein complexes. An unresolve... | lay_plos |
Gene expression of DNA viruses requires nuclear import of the viral genome. Human Adenoviruses (Ads), like most DNA viruses, encode factors within early transcription units promoting their own gene expression and counteracting cellular antiviral defense mechanisms. The cellular transcriptional repressor Daxx prevents v... | To initiate infection, DNA viruses deliver their genome to the nucleus and express viral genes required for genome replication. Efficient transport is achieved by packing the viral genome as a condensed, transcriptionally inactive nucleo-protein complex. However, for most DNA viruses, including Adenoviruses (Ads), it r... | lay_plos |
Kinesin-12 motors are a little studied branch of the kinesin superfamily with the human protein (Kif15) implicated in spindle mechanics and chromosome movement. In this study, we reconstitute full-length hKif15 and its microtubule-targeting factor hTpx2 in vitro to gain insight into the motors mode of operation. We rev... | Before a cell can divide, it produces an extra copy of all its chromosomes, and it must then ensure that each daughter cell ends up with one copy of each chromosome. During the division process, a structure called the spindle forms in the cell. This spindle is made of thread-like extensions called microtubules that gro... | lay_elife |
Glycolytic potential (GP) in skeletal muscle is economically important in the pig industry because of its effect on pork processing yield. We have previously mapped a major quantitative trait loci (QTL) for GP on chromosome 3 in a White Duroc × Erhualian F2 intercross. We herein performed a systems genetic analysis to ... | Glycogen storage diseases (GSD) are a group of inherited disorders characterized by storage of excess glycogen, which are mainly caused by the abnormality of a particular enzyme essential for releasing glucose from glycogen. GSD-like conditions have been described in a wide variety of species. Pigs are a valuable model... | lay_plos |
Mitochondrial complex III (CIII2) and complex IV (CIV), which can associate into a higher-order supercomplex (SC III2+IV), play key roles in respiration. However, structures of these plant complexes remain unknown. We present atomic models of CIII2, CIV, and SC III2+IV from Vigna radiata determined by single-particle c... | Most living things including plants and animals use respiration to release energy from food. Respiration requires the activity of five large protein complexes typically called complex I, II, III, IV and V. Sometimes these complexes combine to form supercomplexes. The complexes are similar across plants, animals and oth... | lay_elife |
In recent years, the East African region has seen an increase in arboviral diseases transmitted by blood-feeding arthropods. Effective surveillance to monitor and reduce incidence of these infections requires the use of appropriate vector sampling tools. Here, trapped skin volatiles on fur from sheep, a known preferred... | The East African region is a major epizootic center for endemic and emerging mosquito borne-arboviruses such as Rift Valley fever virus (RVFV), as evidenced by the increasing frequency and magnitude of this disease. The absence of vaccines or prophylactic drugs for most of these diseases emphasizes the need for accurat... | lay_plos |
Two-component systems (TCSs) are important for the adaptation and survival of bacteria and fungi under stress conditions. A TCS is often composed of a membrane-bound sensor histidine kinase (SK) and a response regulator (RR), which are relayed through sequential phosphorylation steps. However, the mechanism for how an ... | Two-component signal transduction systems (TCSs) are promising targets for new antimicrobial research because they help bacteria and fungi adapt and survive. One of the main components of TCSs is a sensor histidine kinase (SK), which relays extracellular signals to intracellular pathways. Despite intensive research, a ... | lay_plos |
This study describes two longitudinal serological surveys of European Bat Lyssavirus type 1 (EBLV-1) antibodies in serotine bat (Eptesicus serotinus) maternity colonies located in the North-East of France. This species is currently considered as the main EBLV-1 reservoir. Multievent capture-recapture models were used t... | A multi-annual survey of two serotine bat (Eptesicus serotinus) maternity colonies previously found exposed to European Bat Lyssavirus type 1 (EBLV-1) was assessed using capture-recapture methodology. The two roosting site were located in the North-East of France. Animals were trapped, banded, and blood samples were co... | lay_plos |
Neutrophils and dendritic cells (DCs) converge at localized sites of acute inflammation in the skin following pathogen deposition by the bites of arthropod vectors or by needle injection. Prior studies in mice have shown that neutrophils are the predominant recruited and infected cells during the earliest stage of Leis... | Prior studies in mice have shown that the inoculation of Leishmania major into the skin by sand fly bite or by needle provokes a massive recruitment of neutrophils that take up the parasite, and that this response somehow suppresses immunity since neutrophil depletion results in better control of the infection. We inve... | lay_plos |
Dobbin of Ours Cuff's fight with Dobbin, and the unexpected issue of that contest, will long be remembered by every man who was educated at Dr. Swishtail's famous school. The latter Youth (who used to be called Heigh-ho Dobbin, Gee-ho Dobbin, and by many other names indicative of puerile contempt) was the quietest, the... | Another kid at the school was Cuff, who was the popular, bullying jock type. Everyone who was there will always remember the day Dobbin saw Cuff about to beat up George. It's not really clear how old everyone is at this point. We'll hazard a guess that George was 9ish, Dobbin 11ish, and Cuff 14ish. Point being that Cuf... | booksum |
A tweet from Twitter Inc. announcing its initial public offering is shown in this photo illustration in Toronto, September 12, 2013. LOS ANGELES/ SAN FRANCISCO When Twitter goes public in coming weeks, one of the biggest winners will be a 47-year-old financier who guards his secrecy so zealously that he employs a perso... | As Twitter prepares to go public, there's plenty of people waiting in the wings to cash in; yesterday's filings reveal investment firms, board members, and execs will have the highest payouts, but one mysterious Hollywood financier also will add a good chunk of change to his bank account. Suhail Rizvi, whose clients in... | multi_news |
Media playback is not supported on this device 'I would hope that I would win against Serena' Serena Williams disputes John McEnroe's claims that she would struggle to be in the world's top 700 if she was on the men's circuit. But the male player ranked 701 in the world - Dmitry Tursunov - believes he could beat her. S... | Serena Williams is an "incredible player" but she would be ranked "like 700" if she was on the men's circuit, John McEnroe said during an NPR interview Sunday, igniting a fierce debate and drawing a stern response from Williams. "I adore and respect you but please please keep me out of your statements that are not fact... | multi_news |
Inter-individual variation in gene regulatory elements is hypothesized to play a causative role in adverse drug reactions and reduced drug activity. However, relatively little is known about the location and function of drug-dependent elements. To uncover drug-associated elements in a genome-wide manner, we performed R... | Drug response varies between individuals and can be caused by genetic factors. Nucleotide variation in gene regulatory elements can have a significant effect on drug response, but due to the difficulty in identifying these elements, they remain understudied. Here, we used various genomic assays to analyze human liver c... | lay_plos |
Rhadinoviruses establish chronic infections of clinical and economic importance. Several show respiratory transmission and cause lung pathologies. We used Murid Herpesvirus-4 (MuHV-4) to understand how rhadinovirus lung infection might work. A primary epithelial or B cell infection often is assumed. MuHV-4 targeted ins... | All viral infections start with host entry. Entry into cells is studied widely in isolated cultures; entry into live hosts is more complicated and less well understood: our tissues have specific anatomical structures and our cells differ markedly from most cultured cells in size, shape and behaviour. The respiratory tr... | lay_plos |
Background Plasma is the liquid portion of blood, containing nutrients, electrolytes (dissolved salts), gases, albumin, clotting factors, hormones, and wastes. Many different parts of plasma are used in treating the trauma of burns and surgery and for replacing blood elements that are lacking due to diseases such as he... | GAO provided information on blood plasma safety, focusing on: (1) comparing the risks of incorporating infected plasma from donations from volunteer donors with those from paid donors into the manufacturing process; (2) the impact on frequent and infrequent plasma users when pooling large numbers of plasma donations in... | gov_report |
Natural killer T (NKT) cell development depends on recognition of self-glycolipids via their semi-invariant Vα14i-TCR. However, to what extent TCR-mediated signals determine identity and function of mature NKT cells remains incompletely understood. To address this issue, we developed a mouse strain allowing conditional... | Immune system natural killer T (NKT) cells help to protect against certain strains of bacteria and viruses, and suppress the development of autoimmune diseases and cancer. However, NKT cells are also central mediators of allergic responses. The recognition of one' s own glycolipid antigens (self-glycolipids) in the thy... | lay_plos |
As emerging and re-emerging infectious arboviruses like dengue, chikungunya, and Zika threaten new populations worldwide, officials scramble to assess local severity and transmissibility, with little to no epidemiological history to draw upon. Indirect estimates of risk from vector habitat suitability maps are prone to... | When novel infectious diseases like chikungunya or Zika emerge and threaten global spread, public health officials worldwide must assess the risk for local introductions and outbreaks. These assessments are made in anticipation of local case data, and officials must draw upon historic evidence from similar diseases or ... | lay_plos |
Gene conversion, the non-reciprocal exchange of genetic information, is one of the potential products of meiotic recombination. It can shape genome structure by acting on repetitive DNA elements, influence allele frequencies at the population level, and is known to be implicated in human disease. But gene conversion is... | During the production of gametes, most sexually reproducing organisms undergo meiotic recombination. The most familiar form of meiotic recombination is crossing-over, which results in the reciprocal exchange of DNA between parental chromosomes and is important for chromosome segregation as well as generating new alleli... | lay_plos |
The expression of the human papillomavirus (HPV) E6/E7 oncogenes is crucial for HPV-induced malignant cell transformation. The identification of cellular targets attacked by the HPV oncogenes is critical for our understanding of the molecular mechanisms of HPV-associated carcinogenesis and may open novel therapeutic op... | Specific types of human papillomaviruses (HPVs) are closely linked to the development of malignant tumors, such as cervical cancer. Virtually all cervical cancers contain HPV DNA and the tumorigenic growth behavior of cervical cancer cells is dependent on the activity of two viral oncogenes, called E6 and E7. It is imp... | lay_plos |
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