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{
"pmid": 1673585,
"language": "eng"
} | Cardiac beta-adrenoceptor regulation and the effects of partial agonism.
The in vivo effects of xamoterol on the regulation of rat cardiac beta adrenoceptors were investigated. Rats were implanted subcutaneously with osmotic minipumps and exposed to the following treatment regimens: (1) subcutaneous infusion of saline ... |
{
"pmid": 1673586,
"language": "eng"
} | Interrupting the adaptive changes in congestive heart failure.
Circulating plasma concentrations of norepinephrine, renin, angiotensin and vasopressin are increased in congestive heart failure. By increasing ventricular afterload, heart failure is further worsened, which in turn--in a vicious cycle--stimulates neurohum... |
{
"pmid": 1673587,
"language": "eng"
} | Acute and chronic hemodynamic effects of xamoterol in mild to moderate congestive heart failure.
Xamoterol, a new beta 1 partial agonist, has the potential to modulate cardiac response to variations in sympathetic tone in patients with heart failure. Its properties should result in beta-receptor stimulatory effects at ... |
{
"pmid": 1673588,
"language": "eng"
} | Local cardiac responses--alternative methods of control.
Much attention has been paid to the influence of the beta-adrenoceptor system on cardiac function in heart failure. Full agonists and partial agonists acting on cardiac beta 1 receptors have been widely investigated, as has the density of these receptors in the f... |
{
"pmid": 1673589,
"language": "eng"
} | Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men.
The effect of dietary oleic acid (OA), linoleic acid (LA), and linolenic acid (LNA) on plasma lipid metabolism was studied in eight normolipidemic men. A mixed-fat diet composed of conventio... |
{
"pmid": 1673590,
"language": "eng"
} | Depression of thymus-dependent immunity in wasting protein-energy malnutrition does not depend on an altered ratio of helper (CD4+) to suppressor (CD8+) T cells or on a disproportionately large atrophy of the T-cell relative to the B-cell pool.
We report cell numbers within major subsets of lymphocytes in the spleen, m... |
{
"pmid": 1673591,
"language": "eng"
} | Mild intraoperative hypothermia increases duration of action and spontaneous recovery of vecuronium blockade during nitrous oxide-isoflurane anesthesia in humans.
We compared the duration of action and recovery times for vecuronium in normothermic and mildly hypothermic patients. Ten patients were actively cooled to a ... |
{
"pmid": 1673592,
"language": "eng"
} | Vecuronium neuromuscular blockade at the adductor muscles of the larynx and adductor pollicis.
The differences between neuromuscular blockade of the adductor muscles of the vocal cords and the adductor pollicis were examined in 20 adult women anesthetized with fentanyl and propofol. Vecuronium 0.04 or 0.07 mg/kg was gi... |
{
"pmid": 1673593,
"language": "eng"
} | Effects of a histamine type-2 receptor antagonist (BMY-25368) on gastric secretion in horses.
The effects of a potent new histamine-2 (H2) receptor antagonist, BMY-25368, were studied on gastric acid secretion in 5 foals from which food was withheld. Doses of 0.02, 0.11, 0.22, and 1.10 mg/kg of body weight were adminis... |
{
"pmid": 1673594,
"language": "eng"
} | Mental disorders among alcoholics. Relationship to age of onset and cerebrospinal fluid neuropeptides.
Eighty-one percent of 339 alcoholics participating in a research program were found to have associated mental disorders. Alcoholics with onset of heavy drinking before 20 years of age had significantly more antisocial... |
{
"pmid": 1673595,
"language": "eng"
} | Human T-cell leukemia/lymphoma viruses. Life cycle, pathogenicity, epidemiology, and diagnosis.
Human T-cell leukemia/lymphoma virus type I (HTLV-I) was discovered in 1980, and it subsequently was found to be the cause of adult T-cell leukemia/lymphoma. A progressive neurologic disease known as tropical spastic parapar... |
{
"pmid": 1673596,
"language": "eng"
} | S100 protein-positive sustentacular cells in malignant and locally aggressive adrenal pheochromocytomas.
The absence or presence of S100-positive sustentacular cells has been previously shown to be correlated with benign and malignant pheochromocytomas and paragangliomas. We evaluated a total of 17 malignant and recurr... |
{
"pmid": 1673597,
"language": "eng"
} | The impact of ulcerogenic drugs on surgery for the treatment of peptic ulcer disease.
To investigate the impact of ulcerogenic drugs on surgery for the treatment of peptic ulcer disease, we reviewed 150 surgical cases. Ulcerogenic drug use (steroids and/or nonsteroidal anti-inflammatory agents, including aspirin) incre... |
{
"pmid": 1673598,
"language": "eng"
} | Normothermic ischemic cardiac arrest in the isolated working rabbit heart: effects of dl-nebivolol and atenolol.
The effect of pretreatment with selective beta 1-adrenoceptor blockers (dl-nebivolol or atenolol) on myocardial mechanical activity, mitochondrial function, morphology, and calcium cytochemistry was studied ... |
{
"pmid": 1673608,
"language": "eng"
} | A model for collaborative service delivery for students with language-learning disorders in the public schools. Committee on Language Learning Disorders American Speech-Language-Hearing Association.
Collaborative service delivery can augment traditional methods for serving students with language-learning disorders in t... |
{
"pmid": 1673614,
"language": "eng"
} | Effects of L-glutamine, glutaminase and glutamine synthetase on CAP threshold of cochlear nerve of guinea pig.
Negative direct current (-DC 300 microA) stimulation was applied to the round window of the guinea pig cochlea to exhaust the pre-synaptic intracellular reserves of the transmitter in hair cells, and then the ... |
{
"pmid": 1673615,
"language": "eng"
} | Studies on DNA sequence specific binding proteins for 5' flanking upstream region of CPSI gene.
Two specific carbamyl phosphate synthetase I gene binding nuclear proteins (M. W. 109 kD and 74 kD) have been determined in the rat liver by the protein blotting technique (Southwestern blot assay). The result shows that the... |
{
"pmid": 1673616,
"language": "eng"
} | Antihypertensive effect of isradipine on blood pressure at rest and during exercise.
After three months of treatment with isradipine, 20 patients with mild hypertension had reduced their resting blood pressure (BP) from 157/103 to 132/85 mm Hg and their BP during isometric exercise from 192/124 to 166/105 mm Hg. The is... |
{
"pmid": 1673617,
"language": "eng"
} | Lowered responsiveness of bronchoalveolar lavage T lymphocytes in hypersensitivity pneumonitis.
We previously reported that Trichosporon cutaneum was the major causative antigen of summer-type hypersensitivity pneumonitis (HP) in Japan. In summer-type HP patients, we noticed that the proliferative responses of bronchoa... |
{
"pmid": 1673618,
"language": "eng"
} | Acute poisoning with a glyphosate-surfactant herbicide ('Roundup'): a review of 93 cases.
Between 1 January 1980, and 30 September 1989, 93 cases of exposure to herbicides containing glyphosphate and surfactant ('Roundup') were treated at Changhua Christian Hospital. The average amount of the 41% solution of glyphosate... |
{
"pmid": 1673619,
"language": "eng"
} | The efficacy of DTPA treatment after deposition of thorium nitrate in the rat lung.
The efficacy of CaDTPA and ZnDTPA, the chelating agents of choice for several actinide elements, have been evaluated after the deposition of thorium in the rat lung in widely different amounts. The results showed that: 1. When the initi... |
{
"pmid": 1673620,
"language": "eng"
} | Evaluation of severity indexes of patients with paraquat poisoning.
1. Three indexes for evaluating the severity of paraquat poisoning based on plasma-paraquat concentration are presently in use; the curves of Proudfood et al. and Scherrmann et al. and the SIPP. Their effectiveness in determining the prognosis of patie... |
{
"pmid": 1673621,
"language": "eng"
} | Distribution of ethylene oxide in human blood and its implications for biomonitoring.
The distribution of radioactivity following the incubation of human blood with radio-labelled ethylene oxide was investigated in vitro. After incubation, the individual blood samples were separated into lymphocytes and high (Mr greate... |
{
"pmid": 1673622,
"language": "eng"
} | Expression of N-acetyl transferase in a human monocytic cell-line, U937.
1. N-acetyl transferase (NAT) catalyses the acetylation of arylamine and hydrazine drugs and other xenobiotics. The activity of one isozyme (polymorphic NAT) varies amongst individuals but the other (monomorphic NAT) does not. 2. The human monocyt... |
{
"pmid": 1673623,
"language": "eng"
} | Oral pharmacokinetics of fluazifop-butyl in human volunteers.
1. Fluazifop-butyl, the active ingredient of FUSILADE, a selective herbicide, was administered orally to three male volunteers at a dose level of 0.07 mg kg-1 body weight. Over a period of 6 d between 80 and 93% of the dose was excreted in urine as the metab... |
{
"pmid": 1673624,
"language": "eng"
} | Effects of combined exposure to aluminium and ethanol on aluminium body burden and some neuronal, hepatic and haematopoietic biochemical variables in the rat.
The effects of the daily administration of aluminium (25 mg kg-1, orally), ethanol (10% v/v, in drinking water) or both to adult rats, for 6 weeks, on the amount... |
{
"pmid": 1673625,
"language": "eng"
} | Studies on the mutagenicity of a zinc oxide-hexachloroethane smoke.
1. A suitable method has been developed for generating atmospheres of zinc oxide/hexachloroethane smoke (ZnHCE). 2. The smoke was investigated using the Ames test and the micronucleus assay. 3. It was weakly mutagenic to the bacteria, but in the bone m... |
{
"pmid": 1673626,
"language": "eng"
} | Life-threatening ventricular arrhythmia (torsades de pointes) after haloperidol overdose.
A 48-year-old woman developed QT prolongation and episodes of life-threatening ventricular tachycardia (torsades de pointes) after intentional overdose of haloperidol and orphenadrine. The arrhythmia did not respond to conventiona... |
{
"pmid": 1673628,
"language": "eng"
} | Lactation inhibition by the dopamine agonist CV 205-502.
In an open pilot study with a parallel group design 30 bottle feeding women were randomly assigned in a two to one ratio to receive either the new dopamine agonist CV 205-502 or bromocriptine for lactation inhibition. Ten women who intended to breast feed served ... |
{
"pmid": 1673629,
"language": "eng"
} | Fetal liver dysfunction in Rh alloimmunization.
The liver enzymes, aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP), were measured in the blood of 25 fetuses with severe Rh alloimmunization at the time of their first, second and third intravasc... |
{
"pmid": 1673630,
"language": "eng"
} | Anesthetic and hemodynamic effects of dexmedetomidine during isoflurane anesthesia in a canine model.
Dexmedetomidine, an alpha 2-adrenergic agonist, was administered during isoflurane anesthesia to investigate its anesthetic sparing and hemodynamic effects in the canine model. Eleven healthy dogs were anesthetized wit... |
{
"pmid": 1673634,
"language": "eng"
} | Unexplained CD4-positive T-cell deficiency in non-HIV patients presenting as a Pneumocystis carinii pneumonia.
Three cases of Pneumocystis carinii pneumonia occurring in adults with unexplained T-cell defects are reported. No HIV markers were found during the follow up, and neither was any immunosuppressive disease. Th... |
{
"pmid": 1673636,
"language": "eng"
} | Inhibition by erythroid differentiation factor (activin A) of P-glycoprotein expression in multidrug-resistant human K562 erythroleukemia cells.
The K562/VCR cell line, exhibiting acquired multidrug resistance (MDR) with increased expression of a cell surface glycoprotein (P-glycoprotein), was isolated from human eryth... |
{
"pmid": 1673637,
"language": "eng"
} | An antigen immunologically related to the external domain of gp185 is shed from nude mouse tumors overexpressing the c-erbB-2 (HER-2/neu) oncogene.
An antigen, immunologically related to the external domain of the c-erbB-2 (HER-2/neu) protein, was found shed into the serum of nude mice bearing tumors that overexpress t... |
{
"pmid": 1673638,
"language": "eng"
} | Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.
We have cloned a human MDR3 complementary DNA, coding for a P-glycoprotein, into a mammalian expression vector and cotransfected it with a selectable marker into drug-sensitive human BRO melanoma cell... |
{
"pmid": 1673639,
"language": "eng"
} | Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis.
P-glycoprotein mediates classic multidrug resistance by functioning as an efflux pump that excretes lipophilic chemotherapeutic drugs from cancer cel... |
{
"pmid": 1673640,
"language": "eng"
} | Thymocyte maturation following interaction with thymus-derived macrophages.
Murine C57BL/6 thymocytes were cultivated together with syngeneic thymus-derived macrophages (TDM phi) for up to 96 hr to determine whether TDM phi participate in thymocyte maturation. The expression level of H-2b and Thy-1.2 antigens served as... |
{
"pmid": 1673641,
"language": "eng"
} | Granulomas in murine schistosomiasis mansoni contain vasoactive intestinal peptide-responsive lymphocytes.
Granulomas develop around schistosome ova in murine Schistosoma mansoni. These granulomas have eosinophils that produce VIP. It is possible that VIP participates in immunoregulation. VIP-mediated effects usually o... |
{
"pmid": 1673643,
"language": "eng"
} | Assessment of residual curarization using low-current stimulation.
The present study employed train-of-four (TOF) stimulation at a current of 20 mA to assess the incidence and degree of residual neuromuscular blockade in 64 randomly selected Post Anesthesia Care Unit (PACU) patients. Group C (Control, n = 10) had recei... |
{
"pmid": 1673644,
"language": "eng"
} | Continuous vecuronium infusion for prolonged muscle relaxation in children.
Facilitation of mechanical ventilation of the lungs using an infusion of vecuronium in 11 infants and children and four neonates in an intensive care unit is described. A loading dose of vecuronium of 0.1 mg.kg-1 was followed by an infusion at ... |
{
"pmid": 1673645,
"language": "eng"
} | Comparison of two esmolol bolus doses on the haemodynamic response and seizure duration during electroconvulsive therapy.
Twelve ASA physical status I-III patients were enrolled in a double-blind, prospective, randomized, three-way, within-patient crossover study designed to determine the effect of two standard esmolol... |
{
"pmid": 1673646,
"language": "eng"
} | Echocardiographic detection of coronary artery disease during dobutamine infusion.
Two-dimensional echocardiography performed during dobutamine infusion has been proposed as a potentially useful method for detecting coronary artery disease. However, the safety and diagnostic value of dobutamine stress echocardiography ... |
{
"pmid": 1673648,
"language": "eng"
} | Neurohumoral regulation of collateral perfusion.
Mature coronary collaterals, which develop during chronic coronary occlusion, are not simply passive conduits but are capable of active vasomotion. Collateral perfusion must traverse not only these vessels but also proximal and distal coronary vessels. This series of res... |
{
"pmid": 1673649,
"language": "eng"
} | High permanent plasma adrenaline levels: a marker of adrenal medullary disease in medullary thyroid carcinoma.
Increases in urinary, plasma and tumour adrenaline have been previously observed in MEN II patients with phaeochromocytoma. However, the sensitivity of adrenaline for early detection of adrenal medullary disea... |
{
"pmid": 1673650,
"language": "eng"
} | Factors determining the acute pressor response to alcohol.
The pressor response to acute alcohol loading is variable and the factors influencing it are unknown. Data from 34 standardized alcohol loading studies were analysed to try to identify any factor(s) that might predict the pressor response to oral alcohol. The m... |
{
"pmid": 1673651,
"language": "eng"
} | There are few catecholamine- or neuropeptide Y-containing synapses in the intermediolateral cell column of rat thoracic spinal cord.
1. A quantitative electron microscopic immunocytochemical technique was used to assess the number of synapses immunoreactive for tyrosine hydroxylase (TH), phenylethanolamine N-methyl-tra... |
{
"pmid": 1673654,
"language": "eng"
} | Long-term maintenance treatment of reflux esophagitis with omeprazole. Prospective study in patients with H2-blocker-resistant esophagitis.
Thirty-four patients with H2-blocker-resistant reflux esophagitis subsequently healed by 40 mg omeprazole daily entered a maintenance study with 20 mg omeprazole. In 31 evaluable c... |
{
"pmid": 1673655,
"language": "eng"
} | Peroxisomal oxidases in various tissues of diabetic rats.
The effect of diabetes mellitus induced by streptozotocin on the activities of peroxisomal oxidases and H2O2-metabolizing enzymes, and lipid peroxidation in various rat tissues were investigated. Peroxisomal acyl-CoA oxidase, D-amino acid oxidase and L-alpha-hyd... |
{
"pmid": 1673658,
"language": "eng"
} | Bicuculline-induced epileptogenesis in the human neocortex maintained in vitro.
Intracellular and extracellular recordings were made from human neocortical slices of the temporal lobe maintained in vitro. The slices were treated with bicuculline methiodide to reduce synaptic inhibition mediated by tha gamma-aminobutyri... |
{
"pmid": 1673659,
"language": "eng"
} | Morphofunctional study of the effects of fetal exposure to cyproterone acetate on the hypothalamo-pituitary-gonadal axis of adult rats.
Fetal exposure to cyproterone acetate (CPA), while allowing, normal sexual morphogenesis, has previously been shown to lead to functional endocrine abnormalities in adult rats of both ... |
{
"pmid": 1673660,
"language": "eng"
} | Tyrosine hydroxylase immunoreactive neurons in organotypic slice cultures of the rat striatum and neocortex.
Organotypic slice cultures of striatum and neocortex were prepared from newborn to seven day old rats and cultured for three to 60 days. When processed for tyrosine hydroxylase (TH) immunocytochemistry medium-si... |
{
"pmid": 1673663,
"language": "eng"
} | Regulation of rat insulin-receptor kinase by glucose in vivo.
The effects of acute and chronic hyperglycemia on the kinase activity of insulin receptors in vivo were studied in the rat. Skeletal muscle-derived insulin receptors were isolated, with preservation of the in vivo phosphorylation state, from nondiabetic rats... |
{
"pmid": 1673665,
"language": "eng"
} | Sequence of fimbrial subunit-encoding genes from virulent and benign isolates of Dichelobacter (Bacteroides) nodosus.
Both virulent and benign isolates of the ovine pathogen Dichelobacter (Bacteroides) nodosus produce polar fimbriae which have been implicated in twitching motility. The fimbrial subunit-encoding genes f... |
{
"pmid": 1673664,
"language": "eng"
} | Dietary n-3 (omega-3) polyunsaturated fatty acid effects on animal tumorigenesis.
Environmental variables influence the incidence and expression of disease. Dietary fat is one environmental variable that has been associated experimentally and epidemiologically with alterations in certain types of tumorigenesis. Recentl... |
{
"pmid": 1673666,
"language": "eng"
} | Synthesis of the nonconserved dihydroorotase domain of the multifunctional hamster CAD protein in Escherichia coli.
CAD is the multifunctional protein of higher eukaryotes which catalyzes the first three steps of pyrimidine biosynthesis. Its enzymatic activities exist as independent domains in the order: N terminus-car... |
{
"pmid": 1673668,
"language": "eng"
} | Genetic polymorphism of the murine myogenic gene Myo-D1.
Polymorphism of the myogenic gene, Myo-D1, has been sought to examine genetic mechanisms which control skeletal muscle development. By Southern analysis, three restriction-fragment length polymorphisms (RFLPs) have been found in various mouse strains using the Ta... |
{
"pmid": 1673662,
"language": "eng"
} | Two patients with insulin resistance due to decreased levels of insulin-receptor mRNA.
Mutations have been identified in the insulin-receptor gene in insulin-resistant patients. We studied two patients with acanthosis nigricans and insulin resistance caused by a decrease in the number of cell surface insulin receptors.... |
{
"pmid": 1673667,
"language": "eng"
} | Expression of an immunogenic region of HIV by a filamentous bacteriophage vector.
Vectors derived from the Escherichia coli filamentous phage, fd-tet, expressing parts of the human immunodeficiency virus (HIV) gag genes were constructed and analyzed. The immunoreactive domain of HIV Gag antigens was produced in the for... |
{
"pmid": 1673661,
"language": "eng"
} | In vivo benzodiazepine receptor occupancy by CL 218,872 visualized by positron emission tomography in the brain of the living baboon: modulation by GABAergic transmission and relation with anticonvulsant activity.
In vivo benzodiazepine receptor occupancy by increasing doses of CL 218,872 has been evaluated in the babo... |
{
"pmid": 1673669,
"language": "eng"
} | Development of environmentally compatible controlled release formulations of a mosquito larvicide.
A new controlled release system of a mosquito larvicide, fenthion has been developed by the chemical modification of sodium carboxymethylcellulose into a hydrophobic gel of copper carboxymethylcellulose. Four formulations... |
{
"pmid": 1673671,
"language": "eng"
} | Somatostatin cells in rat antral mucosa: qualitative and quantitative ultrastructural analyses in different states of gastric acid secretion.
In the gastrointestinal tract somatostatin is localized in endocrine cells and in neurons. The antral somatostatin (D-) cell shares features of both cell types. The activity of t... |
{
"pmid": 1673672,
"language": "eng"
} | DARPP-32 like protein in specific snail (Helix aspersa) neurones.
Monoclonal antibodies to DARPP-32 recognise an antigen which is present in specific neurones in the snail (Helix aspersa). Consecutive sections 10-microns-thick processed for the localisation of DARPP-32 and tyrosine-hydroxylase immunoreactivity did not ... |
{
"pmid": 1673673,
"language": "eng"
} | Linkage disequilibrium between the HLA-DQA2 alleles and the HLA/DR/DQ complex.
A statistically significant association was observed between alleles of the HLA-DQA2 and of the DR/DQ complex in a DNA-restriction fragment length polymorphism study of 219 members from 21 multiplex families of patients with hyperthyroid Gra... |
{
"pmid": 1673674,
"language": "eng"
} | Diversity among DRw13 DQw7 haplotypes as revealed by serology Dw typing and restriction fragment length polymorphism.
HLA-DRw13 is in linkage disequilibrium with DQw6; an unusual association, DRw13 DQw7, is found in 2% of our Caucasoid population. Investigation of genotyped individuals and of families by two allosera a... |
{
"pmid": 1673678,
"language": "eng"
} | Effects of nitric oxide on platelet-activating factor- and alpha-adrenergic-stimulated vasoconstriction and glycogenolysis in the perfused rat liver.
Effects of nitric oxide (NO) on hemodynamic and glycogenolytic responses to platelet-activating factor (PAF) and phenylephrine were investigated in perfused livers derive... |
{
"pmid": 1673679,
"language": "eng"
} | Characterization of the functional domains of the natriuretic peptide receptor/guanylate cyclase by radiation inactivation.
Radiation inactivation has been used to evaluate the molecular size of domains responsible for atrial natriuretic peptide (ANP)-binding and cyclase functions of the ANP receptor/guanylate cyclase.... |
{
"pmid": 1673680,
"language": "eng"
} | Biosynthetic thiolase from Zoogloea ramigera. Evidence for a mechanism involving Cys-378 as the active site base.
Biosynthetic thiolase from Zoogloea ramigera was inactivated with a mechanism-based inactivator, 3-pentynoyl-S-pantetheine-11-pivalate (3-pentynoyl-SPP) where K1 = 1.25 mM and kinact = 0.26 min-1, 2,3-penta... |
{
"pmid": 1673681,
"language": "eng"
} | Purification and tissue level of the beta-amyloid peptide precursor of rat brain.
The beta-amyloid peptide precursor (beta-APP) exists in brain tissue as a membrane-associated protein extractable with 1% Triton X-100. beta-APP has been purified to near homogeneity by the following procedure: 1) anion exchange chromatog... |
{
"pmid": 1673682,
"language": "eng"
} | Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP).
The human gene for the recently identified 5-lipoxy-genase-activating protein (FLAP) has been cloned. The gene was isolated from two different genomic libraries and is contained within four overlapping bacteriophage clone... |
{
"pmid": 1673683,
"language": "eng"
} | Purification and identification of photoreceptor guanylate cyclase.
Photoreceptor guanylate cyclase was solubilized and purified from bovine rod outer segments with 50-150-fold increase in specific activity using the nonionic detergent n-dodecyl-beta-D-maltoside. Guanylate cyclase activities correlated with the enrichm... |
{
"pmid": 1673685,
"language": "eng"
} | The efficacy and tolerability of CV 205-502 (a nonergot dopaminergic drug) in macroprolactinoma patients and in prolactinoma patients intolerant to bromocriptine.
We studied the effect of CV 205-502 in 12 patients with macroprolactinomas and 8 patients with PRL-secreting tumors, who were selected because of previous re... |
{
"pmid": 1673686,
"language": "eng"
} | Investigation and characterization of receptors for pituitary adenylate cyclase-activating polypeptide in human brain by radioligand binding and chemical cross-linking.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a novel peptide of hypothalamic origin which increases adenylate cyclase activity in rat ... |
{
"pmid": 1673687,
"language": "eng"
} | Interleukin 2 therapy in severe atopic dermatitis.
Interleukin 2 (IL-2) at a dose of 10,000 to 20,000 U/kg/q 8 hr was given for 9-12 days to six patients with cases of severe atopic dermatitis (AD) which were refractory to conventional therapy. After IL-2 therapy, the clinical symptoms and signs of eczema including pru... |
{
"pmid": 1673691,
"language": "eng"
} | Endothelial expression of intercellular adhesion molecule (ICAM-1) is unaffected by marrow aplasia-inducing chemotherapy.
Sequential skin biopsies were obtained from five patients receiving chemotherapy for acute myelocytic leukemia. The first specimen was taken on the fourth day of initial chemotherapy and subsequent ... |
{
"pmid": 1673692,
"language": "eng"
} | A controlled study of disruptive vocalizations among geriatric residents in nursing homes.
This paper reports the results of a controlled study comparing geriatric residents in nursing homes who displayed disruptive vocalizations with residents in a comparison group. Two 350-bed nursing homes were surveyed, and it was ... |
{
"pmid": 1673694,
"language": "eng"
} | Changes in urinary proximal tubule parameters in neonatal rats exposed to cadmium chloride during pregnancy.
Pregnant Sprague-Dawley rats were injected intraperitoneally with physiological saline solution (vehicle) or cadmium chloride (CdCl2) at 2.0 or 2.5 mg kg-1 on days 8, 10, 12 and 14 of gestation. On postnatal day... |
{
"pmid": 1673695,
"language": "eng"
} | Opioid, 5-HT1A and alpha 2 receptors localized to subsets of guinea-pig myenteric neurons.
The expression of mu opioid, alpha 2 and 5-hydroxytryptamine1A (5-HT1A) receptors on guinea-pig myenteric neurons was determined using receptor selective agonists during intracellular recordings in vitro. Agonists known to hyperp... |
{
"pmid": 1673696,
"language": "eng"
} | Effect of guanethidine on dopamine in small intensely fluorescent cells of the superior cervical ganglion of the rat.
To determine the portion of ganglionic dopamine stored in the small intensely fluorescent (SIF) cells of the superior cervical ganglion, rats were treated chronically with the neurotoxin guanethidine (5... |
{
"pmid": 1673697,
"language": "eng"
} | Opioid innervation of the caudal ventrolateral medulla is not critical for the expression of the aortic depressor nerve response in the rabbit.
We investigated the influence of endogenous opioids in the caudal ventrolateral medulla (CVLM) on the expression of the baroreflex response induced by the electrical stimulatio... |
{
"pmid": 1673698,
"language": "eng"
} | Cellular, immunologic and biochemical characterization of topical retinoic acid-treated human skin.
Histologic and clinical improvement of sun-exposed skin following topical treatment with retinoic acid has been reported. Daily application of retinoic acid typically results within 2-5 d in an erythematous scaling react... |
{
"pmid": 1673708,
"language": "eng"
} | Recovery of amino acid neurotransmitters from the spinal cord during posterior epidural stimulation: a preliminary study.
Continuous posterior epidural spinal cord stimulation (SCS) has been an effective method for treating spasticity. The mechanisms of SCS include activation of inhibitory segmental neuronal systems an... |
{
"pmid": 1673709,
"language": "eng"
} | Cytokine-induced expression of intercellular adhesion molecule-1 (ICAM-1) in cultured human oligodendrocytes and astrocytes.
We investigated the expression of intercellular adhesion molecule-1 (ICAM-1) on primary cultures of human adult oligodendrocytes and astrocytes. Under unstimulated conditions, low levels of ICAM-... |
{
"pmid": 1673710,
"language": "eng"
} | Molecular forms of soluble human T lymphocyte receptor for sheep erythrocytes in serum and saliva.
Using a specific serum anti-soluble T lymphocytes receptor for sheep erythrocytes (E) and SDS-PAGE, we detected radioactive bands of molecular weight 58,000 in immunoprecipitates of supernatant of heated human lymphocytes... |
{
"pmid": 1673711,
"language": "eng"
} | Subsequent testicular histology: fertility and fecundity of rats subjected to unilateral incarcerated inguinal hernia during the prepubertal period.
An experimental study was designed to evaluate subsequent ipsilateral and contralateral testicular histologies, fertility, and fecundity of rats subjected to unilateral in... |
{
"pmid": 1673712,
"language": "eng"
} | Brain growth and cognitive improvement in children with human immunodeficiency virus-induced encephalopathy after 6 months of continuous infusion zidovudine therapy.
The ventricular area at the level of the foramen of Monro was measured from axial x-ray computed tomography (CT) scans obtained prior to and 6 months afte... |
{
"pmid": 1673713,
"language": "eng"
} | Serum erythropoietin titers in patients with human immunodeficiency virus (HIV) infection and anemia.
The pathophysiology of anemia in patients with human immunodeficiency virus (HIV) infection is multifactorial. In order to determine the role of erythropoietin (EPO) response as a cause of the anemia, serum levels were... |
{
"pmid": 1673714,
"language": "eng"
} | Lymphocyte immunophenotypes among anti-HTLV-I/II-positive blood donors and recipients. The Transfusion Safety Study Group.
The Transfusion Safety Study retrospectively screened a repository of serum specimens collected in late 1984-early 1985 to identify blood donors with antibody to human T-cell lymphotropic virus (HT... |
{
"pmid": 1673720,
"language": "eng"
} | Restriction fragment length polymorphism analysis of HLA-DR, DQ, DP and C4 alleles in Caucasians with systemic lupus erythematosus.
HLA-DR, DQ, DP and C4 null alleles were determined by restriction fragment length polymorphism (RFLP) analysis in 60 Caucasian patients with systemic lupus erythematosus (SLE) and 66 contr... |
{
"pmid": 1673721,
"language": "eng"
} | Toxicity profiles of disease modifying antirheumatic drugs in rheumatoid arthritis.
The toxicity profiles of 7 disease modifying antirheumatic drugs (DMARD) (hydroxychloroquine, intramuscular (im) gold, D-penicillamine, oral gold, methotrexate (MTX), azathioprine and cyclophosphamide) were evaluated in 2,479 patients w... |
{
"pmid": 1673722,
"language": "eng"
} | Response to sulfasalazine in rheumatoid arthritis: life table analysis of a 5-year followup.
Eighty-six patients with rheumatoid arthritis treated with sulfasalazine were followed for 5 years, or until treatment was discontinued. At the end of 5 years, there was a 22% probability of successfully continuing treatment. M... |
{
"pmid": 1673723,
"language": "eng"
} | Astemizole, an H1 antagonist, has no additional therapeutic effect in rheumatoid arthritis.
Mast cells are found in increased numbers in the synovium of patients with rheumatoid arthritis (RA) and may play a role in synovitis. They produce proinflammatory substances including histamine. A double blind placebo controlle... |
{
"pmid": 1673724,
"language": "eng"
} | Embolization of cardiac myxomas masquerading as polyarteritis nodosa.
Cardiac myxomas are rare tumors which can mimic other diseases. We describe a 19-year-old man who presented clinically with polyarteritis nodosa (PAN). Muscle biopsy showed vasculitis, but corticosteroid and immunosuppressive therapy was initially ef... |
{
"pmid": 1673727,
"language": "eng"
} | Allele loss at the retinoblastoma locus in human ovarian cancer.
To gain a broad spectrum on allelic loss of specific loci in ovarian tumors, we initially examined DNA from 23 pairs of ovarian tumors and matched peripheral blood lymphocyte samples from the same patients, using 27 polymorphic DNA markers distributed on ... |
{
"pmid": 1673728,
"language": "eng"
} | The operational costs of spraying residual insecticides: a case-study from Nepal.
Little attention has been paid to the cost implications of different insecticides for malaria control, particularly to the local (non-insecticide) costs. This study in Nepal explored the significance of operational costs in relation to in... |
{
"pmid": 1673730,
"language": "rus"
} | [Effect of adrenergic beta blockers on hemodynamics, diastolic relaxation and distensibility of left-ventricular myocardium in patients with ischemic heart disease].
Altogether 32 patients were investigated by catheterization of the left ventricular cavity with volume loading of 76% solution of verographin++ administer... |
{
"pmid": 1673731,
"language": "rus"
} | [Comparative effectiveness of psychotropic drugs in patients with chronic ischemic heart disease].
As many as 348 courses of psychotropic and antianginal chemotherapy were performed for coronary disease confirmed angiographically. Hypochondriac patients were resistant to the drugs, depressive states and anxiety showed ... |
{
"pmid": 1673733,
"language": "eng"
} | Reduction of infarct size by systemic amino acid supplementation during reperfusion.
The amino acids aspartate and glutamate, in combination, were evaluated as a means of reducing infarct size and improving cardiac function during reperfusion in an intact pig having an acute anteroseptal infarct. Three groups of 6 pigs... |
{
"pmid": 1673736,
"language": "eng"
} | Randomised study of antiepileptic drug withdrawal in patients in remission. Medical Research Council Antiepileptic Drug Withdrawal Study Group.
A prospective multicentre randomised study of continued antiepileptic treatment vs slow withdrawal was conducted in 1013 patients who had been free of seizures for at least 2 y... |
{
"pmid": 1673737,
"language": "eng"
} | Scheduling of revaccination against hepatitis B virus.
Studies have shown that to maintain protection against infection after a primary course of hepatitis B immunisation, revaccination can be scheduled on the basis of an anti-hepatitis B virus surface antigen (anti-HBs) titre obtained 1 month after the booster dose. H... |
{
"pmid": 1673738,
"language": "eng"
} | Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals.
To identify factors contributing to the pathogenesis of autoimmune chronic active hepatitis (CAH) healthy relatives of 13 patients with the disorder were followed prospectively for 4 years. 58 relatives ... |
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